PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21946215-4	2011	Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells.	CHEMBL408967	160-163	ribonucleotide reductase M2	Mus musculus	70-74
24103640-9	2013	Co-expression of the CTF and full-length YB-1 resulted in an abrogated transcriptional activation of the MMP-2 promoter, indicating an autoregulatory inhibitory loop, whereas it fulfilled similar trans-repressive effects on the collagen type I promoter.	CHEMBL408967	21-24	matrix metallopeptidase 2	Homo sapiens	105-110
22399757-5	2012	FBL2 bound with APP specifically at its C-terminal fragment (CTF), which promoted APP/CTF ubiquitination.	CHEMBL408967	61-64	F-box and leucine-rich repeat protein 20	Mus musculus	0-4
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	187-190	polycystin 1, transient receptor potential channel interacting	Mus musculus	70-73
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	187-190	polycystin 1, transient receptor potential channel interacting	Mus musculus	75-83
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	187-190	polycystin 1, transient receptor potential channel interacting	Mus musculus	75-78
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	187-190	polycystin 1, transient receptor potential channel interacting	Mus musculus	75-78
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	266-269	polycystin 1, transient receptor potential channel interacting	Mus musculus	70-73
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	266-269	polycystin 1, transient receptor potential channel interacting	Mus musculus	75-83
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	266-269	polycystin 1, transient receptor potential channel interacting	Mus musculus	75-78
24958103-3	2014	GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF.	CHEMBL408967	266-269	polycystin 1, transient receptor potential channel interacting	Mus musculus	75-78
24958103-7	2014	By functional genetic complementation with five Pkd1 mouse models, we discovered that CTF plays a crucial role in Pc1(deN) trafficking.	CHEMBL408967	86-89	polycystin 1, transient receptor potential channel interacting	Mus musculus	48-52
24958103-7	2014	By functional genetic complementation with five Pkd1 mouse models, we discovered that CTF plays a crucial role in Pc1(deN) trafficking.	CHEMBL408967	86-89	polycystin 1, transient receptor potential channel interacting	Mus musculus	114-117
24705369-7	2014	The reduction of SNX17 was associated with accumulation of an ApoER2 carboxy-terminal fragment (CTF).	CHEMBL408967	96-99	sorting nexin 17	Homo sapiens	17-22
24705369-7	2014	The reduction of SNX17 was associated with accumulation of an ApoER2 carboxy-terminal fragment (CTF).	CHEMBL408967	96-99	LDL receptor related protein 8	Homo sapiens	62-68
24009667-8	2013	Generation of CTF and EpICD fragments and the degradation of hEpICD via the proteasome were similarly demonstrated for the human EpCAM ortholog.	CHEMBL408967	14-17	epithelial cell adhesion molecule	Homo sapiens	129-134
21946215-4	2011	Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells.	CHEMBL408967	160-163	TAR DNA binding protein	Mus musculus	79-85
21946215-4	2011	Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells.	CHEMBL408967	160-163	ribonucleotide reductase M2	Mus musculus	138-142
21946215-4	2011	Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells.	CHEMBL408967	160-163	TAR DNA binding protein	Mus musculus	153-159
21967679-7	2011	The association rate constant (k(a)) of plasma VWF binding at a wall shear stress of 45 dyn/cm(2) was 0.3 x 10(5), 1.8 x 10(5), and 1.6 x 10(5) M(-1) s(-1) for CTF grown from 10, 100, and 1000 mug/mL solutions, respectively.	CHEMBL408967	160-163	von Willebrand factor	Homo sapiens	47-50
20978202-10	2010	With these antibodies, we showed that, whereas the frequency of ER positivity in HER2-positive/611-CTF-negative tumors (72.6%) is similar to that reported for HER2-negative tumors (70-80%), the number of ER-positive tumors in the 611-CTF-positive subgroup is very low (31.2%).	CHEMBL408967	99-102	estrogen receptor 1	Homo sapiens	64-66
20978202-10	2010	With these antibodies, we showed that, whereas the frequency of ER positivity in HER2-positive/611-CTF-negative tumors (72.6%) is similar to that reported for HER2-negative tumors (70-80%), the number of ER-positive tumors in the 611-CTF-positive subgroup is very low (31.2%).	CHEMBL408967	234-237	estrogen receptor 1	Homo sapiens	64-66
11731004-4	2001	Interestingly, the phosphorylation of PS2 modulates the production of the smaller, caspase-derived PS2 CTF, which indicates that the generation of this fragment is a regulated, physiologic event.	CHEMBL408967	103-106	presenilin 2	Homo sapiens	38-41
19357348-7	2009	Also, we demonstrate that the lack of endogenous Wwox in MDA-MB231 cells represented a molecular mechanism for intranuclear Met-CTF accumulation and for the decrease of full-length Met stability.	CHEMBL408967	128-131	WW domain containing oxidoreductase	Homo sapiens	49-53
18495341-8	2009	It illuminates that this model is reliable to optimize the adsorption process and CTF is suitable for adsorbing Pb(II) from aqueous solution.	CHEMBL408967	82-85	submaxillary gland androgen regulated protein 3B	Homo sapiens	112-118
17311707-5	2007	The CTF corresponds to a PSF with a full-width at half-maximum (FWHM) of 130 nm.	CHEMBL408967	4-7	insulin like growth factor binding protein 7	Homo sapiens	25-28
16440311-4	2006	We now report that, in conjunction with CTF formation, collagen type I stimulates concentration-dependent, saturable shedding of the DDR1 ectodomain from two carcinoma cell lines, and from transfected cells.	CHEMBL408967	40-43	discoidin domain receptor tyrosine kinase 1	Homo sapiens	133-137
16440311-8	2006	The hydroxamate-based metalloproteinase inhibitor TAPI-1 (tumor necrosis factor-alpha protease inhibitor-1), and tissue inhibitor of metalloproteinase (TIMP)-3, also blocked collagen-evoked DDR1 shedding, but did not reduce levels of the phosphorylated CTF.	CHEMBL408967	253-256	discoidin domain receptor tyrosine kinase 1	Homo sapiens	190-194
16440311-10	2006	The results demonstrate that collagen-evoked ectodomain cleavage of DDR1 is mediated in part by Src-dependent activation or recruitment of a matrix- or disintegrin metalloproteinase, and that CTF formation can occur independently of ectodomain shedding.	CHEMBL408967	192-195	discoidin domain receptor tyrosine kinase 1	Homo sapiens	68-72
15975090-6	2005	Using wild-type HEK-293 cells (human embryonic kidney 293 cells) and PS-inducible cells, we now show that overexpression of either ubiquilin-1 or -2 decreases the PS NTF and CTF levels.	CHEMBL408967	174-177	ubiquilin 1	Homo sapiens	131-148
15975090-7	2005	Conversely, siRNA (small interfering RNA)-mediated knockdown of ubiquilin-1 and -2 proteins increased the PS NTF and CTF levels.	CHEMBL408967	117-120	ubiquilin 1	Homo sapiens	64-82
15935913-0	2005	ACE: automated CTF estimation.	CHEMBL408967	15-18	angiotensin I converting enzyme	Homo sapiens	0-3
14527729-7	2003	Human PS1 CTF exogenously injected was also phosphorylated in Xenopus oocytes induced to mature in vitro by progesterone treatment.	CHEMBL408967	10-13	presenilin 1	Homo sapiens	6-9
20043227-5	2010	In the cerebella of six control individuals, the CTF was detected in sucrose- and SDS-soluble cytosolic fractions; in the cerebella of two SCA6 patients, it was additionally detected in SDS-insoluble cytosolic and sucrose-soluble nuclear fractions.	CHEMBL408967	49-52	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	139-143
19522733-2	2009	We demonstrate that TDP-43 can be proteolytically processed by caspases upon induction of apoptosis to a major 35 kDa and a minor 25 kDa CTF.	CHEMBL408967	137-140	TAR DNA binding protein	Homo sapiens	20-26
19524299-7	2009	Here, we demonstrate that two membrane-tethered CD21 CTFs of 8 and 16kDa are constitutively present in human B cells, while only the 8kDa CTF was detectable in murine B cells.	CHEMBL408967	53-56	complement C3d receptor 2	Homo sapiens	48-52
17150042-6	2007	To show that the HLA-A2 CTF is subsequently cleaved by PS1/gamma-secretase, we re-duced its activity in cell lines stably expressing HLA-A2 and in Jurkat T-cells expressing endogenous MHC I.	CHEMBL408967	24-27	presenilin 1	Homo sapiens	55-58
15659814-7	2004	Our result show that the APP, CTF, and ShcA interaction is induced only upon overexpression of BACE1 either transiently or in stable cell lines.	CHEMBL408967	30-33	beta-secretase 1	Homo sapiens	95-100
11731004-4	2001	Interestingly, the phosphorylation of PS2 modulates the production of the smaller, caspase-derived PS2 CTF, which indicates that the generation of this fragment is a regulated, physiologic event.	CHEMBL408967	103-106	presenilin 2	Homo sapiens	99-102
10220591-4	1999	Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9.	CHEMBL408967	30-33	interleukin 1 alpha	Homo sapiens	60-73
10561499-3	1999	We found that expression of CTF markedly increased, similarly to the intact protein, JNK dephosphorylation in heat-shocked cells.	CHEMBL408967	28-31	mitogen-activated protein kinase 8	Homo sapiens	85-88
11585344-5	2001	The proform or the CTF portion of OIP-2 inhibited OCL formation in a dose-dependent manner in murine bone marrow cultures stimulated with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	CHEMBL408967	19-22	occludin	Mus musculus	50-53
11278424-12	2001	Interestingly, when the 25-kDa PS2 CTF and the 20-kDa PS2 CTF are both present, calsenilin preferentially interacts with the 20-kDa CTF.	CHEMBL408967	35-38	presenilin 2	Homo sapiens	31-34
11278424-12	2001	Interestingly, when the 25-kDa PS2 CTF and the 20-kDa PS2 CTF are both present, calsenilin preferentially interacts with the 20-kDa CTF.	CHEMBL408967	35-38	potassium voltage-gated channel interacting protein 3	Homo sapiens	80-90
12903398-4	2000	The interaction site between domains within PS1 located at amino acid 361-447 of PS1 CTF, without the involvement of other partners.	CHEMBL408967	85-88	presenilin 1	Homo sapiens	44-47
12903398-4	2000	The interaction site between domains within PS1 located at amino acid 361-447 of PS1 CTF, without the involvement of other partners.	CHEMBL408967	85-88	presenilin 1	Homo sapiens	81-84
10220591-4	1999	Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9.	CHEMBL408967	30-33	interleukin 1 alpha	Homo sapiens	75-79
10220591-4	1999	Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9.	CHEMBL408967	30-33	matrix metallopeptidase 2	Homo sapiens	82-121
10220591-4	1999	Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9.	CHEMBL408967	30-33	matrix metallopeptidase 9	Homo sapiens	176-181
10220591-5	1999	The degradation of proteoglycan was inhibited by and MMP inhibitor, indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF.	CHEMBL408967	164-167	matrix metallopeptidase 2	Homo sapiens	84-88
10220591-9	1999	High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation.	CHEMBL408967	29-32	interleukin 1 alpha	Homo sapiens	63-67
10220591-9	1999	High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation.	CHEMBL408967	29-32	matrix metallopeptidase 9	Homo sapiens	72-77
10220591-9	1999	High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation.	CHEMBL408967	29-32	matrix metallopeptidase 2	Homo sapiens	122-134
10220591-9	1999	High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation.	CHEMBL408967	29-32	interleukin 1 alpha	Homo sapiens	237-241
10220591-9	1999	High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation.	CHEMBL408967	29-32	matrix metallopeptidase 9	Homo sapiens	246-251
9144240-6	1997	Stimulation of PKC causes a 4- to 5-fold increase of the phosphorylation of the approximately 20-kDa CTF of PS-1 resulting in reduced mobility in SDS gels.	CHEMBL408967	101-104	proline rich transmembrane protein 2	Homo sapiens	15-18
9990034-5	1999	Recently, we found that the CTF of PS-2 is phosphorylated in vivo.	CHEMBL408967	28-31	presenilin 2	Homo sapiens	35-39
9144195-3	1997	Using COS7 cells transfected with human PS1, we have found that phorbol 12, 13-dibutyrate and forskolin increase the state of phosphorylation of serine residues of the human CTF.	CHEMBL408967	174-177	presenilin 1	Homo sapiens	40-43
9144195-8	1997	Upon phosphorylation of the PS1 CTF, the apparent mass of the NTF- or CTF-containing oligomers was unchanged.	CHEMBL408967	32-35	presenilin 1	Homo sapiens	28-31
9507053-10	1998	In dMEA and CTF, nuclear colocalization of AR-ir and mating-induced Fos-ir was present in a proportion of FG-containing neurons.	CHEMBL408967	12-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-71
9144240-6	1997	Stimulation of PKC causes a 4- to 5-fold increase of the phosphorylation of the approximately 20-kDa CTF of PS-1 resulting in reduced mobility in SDS gels.	CHEMBL408967	101-104	presenilin 1	Homo sapiens	108-112
8803927-10	1996	Moreover, we observed that the binding activities of TFIID, CTF, and binding proteins to -40, -120 and -260 regions increased.	CHEMBL408967	60-63	TATA-box binding protein	Homo sapiens	53-58
2182023-1	1990	We designed a radioimmunoassay (RIA) specific for the C-terminal fragment (CTF, 22-39) of porcine big endothelin-1 (big ET-1, 1-39), and investigated whether the generation of ET-1 (1-21) is concomitant with that of the CTF during incubation of big ET-1 with the endothelial cell (EC)-extract.	CHEMBL408967	75-78	endothelin 1	Homo sapiens	102-114
7529108-9	1994	For thermolysin the relative rates of hydrolysis were found to be big ET-1 > CTF > ET-1.	CHEMBL408967	80-83	endothelin 1	Homo sapiens	70-74
7529108-9	1994	For thermolysin the relative rates of hydrolysis were found to be big ET-1 > CTF > ET-1.	CHEMBL408967	80-83	endothelin 1	Homo sapiens	89-93
7529108-18	1994	Both ET-l-like and CTF-like peaks were detected at 214 nm when the products of big ET-1 hydrolysis by thermolysin were resolved by h.p.l.c.	CHEMBL408967	19-22	endothelin 1	Homo sapiens	83-87
31744884-9	2020	Dp44mT and a gamma-secretase inhibitor increased cellular c-Met CTF levels, suggesting that Dp44mT induces c-Met CTF levels by increasing metalloprotease activity.	CHEMBL408967	64-67	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	58-63
35414534-7	2022	Specifically, APOER2 isoforms lacking exons 5-8 (Deltaex5-8) and lacking exons 4-6 (Deltaex4-6) generated the highest and lowest amounts of CTF generation, respectively in response to APOE peptide compared to APOER2-FL.	CHEMBL408967	140-143	LDL receptor related protein 8	Homo sapiens	14-20
35414534-7	2022	Specifically, APOER2 isoforms lacking exons 5-8 (Deltaex5-8) and lacking exons 4-6 (Deltaex4-6) generated the highest and lowest amounts of CTF generation, respectively in response to APOE peptide compared to APOER2-FL.	CHEMBL408967	140-143	apolipoprotein E	Homo sapiens	184-188
35414534-7	2022	Specifically, APOER2 isoforms lacking exons 5-8 (Deltaex5-8) and lacking exons 4-6 (Deltaex4-6) generated the highest and lowest amounts of CTF generation, respectively in response to APOE peptide compared to APOER2-FL.	CHEMBL408967	140-143	LDL receptor related protein 8	Homo sapiens	209-215
33389205-2	2021	The microporous CTF with fluorene backbone was coupled and grown uniformly on the surface of phenyl-functionalized KCC-1 to prepare a hybrid extended porous framework.	CHEMBL408967	16-19	solute carrier family 12 member 4	Homo sapiens	115-120
35475353-5	2022	It was found that sulfur-doped CTF (S-CTF-1) showed a 25.6-fold increase in saturated adsorption capacity (554.7 mumol/g) and a 169.0-fold surge in photocatalytic kinetics (5.07 h-1), respectively, compared with the pristine CTF-1.	CHEMBL408967	31-34	cardiotrophin 1	Homo sapiens	225-230
3757032-4	1986	I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF.	CHEMBL408967	50-53	heat shock factor protein	Xenopus laevis	70-101
3757032-4	1986	I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF.	CHEMBL408967	50-53	heat shock factor protein	Xenopus laevis	103-107
3757032-4	1986	I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF.	CHEMBL408967	50-53	heat shock factor protein	Xenopus laevis	144-148
3757032-4	1986	I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF.	CHEMBL408967	50-53	heat shock factor protein	Xenopus laevis	144-148
31744884-9	2020	Dp44mT and a gamma-secretase inhibitor increased cellular c-Met CTF levels, suggesting that Dp44mT induces c-Met CTF levels by increasing metalloprotease activity.	CHEMBL408967	64-67	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	107-112
31441220-2	2019	The high-PF6 - -content CTF shows the CO2 adsorption of 44.7 cm3  g-1 and I2 capture capacity of 312 wt %.	CHEMBL408967	24-27	sperm associated antigen 17	Homo sapiens	9-12
31377584-3	2019	It is unknown whether CTF-induced IL6 regulates the expression of MMPs, enzymes needed for tissue remodeling.	CHEMBL408967	22-25	interleukin 6	Homo sapiens	34-37
31377584-3	2019	It is unknown whether CTF-induced IL6 regulates the expression of MMPs, enzymes needed for tissue remodeling.	CHEMBL408967	22-25	matrix metallopeptidase 3	Homo sapiens	66-70
31377584-5	2019	Using a neutralizing anti-IL6 antibody and addition of recombinant human IL6 at concentrations of 0.1, 1, 10 ng.mL-1 were performed to clarify whether CTF-upregulated IL6 increased MMP expression.	CHEMBL408967	151-154	interleukin 6	Homo sapiens	26-29
31377584-10	2019	CONCLUSION: Our findings suggest a role of CTF in the modulation of expression of IL6 and MMP3 and thus in the regulation of homeostasis and remodeling of the periodontal ligament.	CHEMBL408967	43-46	interleukin 6	Homo sapiens	82-85
31377584-10	2019	CONCLUSION: Our findings suggest a role of CTF in the modulation of expression of IL6 and MMP3 and thus in the regulation of homeostasis and remodeling of the periodontal ligament.	CHEMBL408967	43-46	matrix metallopeptidase 3	Homo sapiens	90-94
30978553-5	2019	RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group.	CHEMBL408967	149-152	interleukin 1 beta	Rattus norvegicus	83-88
31264863-4	2019	Benefiting from these defects, the adsorption sites with high energy for adsorbing volatile aromatic pollutants were significantly increased, which are reflected by higher saturated adsorption capacities of CTF-m (3.026 mmol/g for benzene (BEN), 1.490 mmol/g for naphthalene (NAP), and 0.863 mmol/g for phenol (PHE)) compared with those of CTF-1 and CTF-2.	CHEMBL408967	207-210	cardiotrophin 1	Homo sapiens	340-345
31358631-3	2019	We studied this complex for dynamic conformational changes 1) at low and high [Ca2+] (pCa 9.0 and 4.5), and 2) upon myosin binding to the cTF in the nucleotide-free state or in the presence of ATP.	CHEMBL408967	138-141	myosin heavy chain 14	Homo sapiens	116-122
31358631-6	2019	The weakly and strongly bound myosin induce similar changes in the structure of cTFs as confirmed by the local dynamical displacement of individual tropomyosin strands in the center of a regulatory unit of cTF at the relaxed and activation conditions.	CHEMBL408967	80-83	myosin heavy chain 14	Homo sapiens	30-36
31388055-5	2019	Pharmacological inhibition of BMP1 or siRNA-mediated knockdown prevented the generation of the 120 kDa CTF and resulted in an increase in LDL uptake into cells.	CHEMBL408967	103-106	bone morphogenetic protein 1	Homo sapiens	30-34
31388055-6	2019	The 120 kDa CTF was detected in the livers from humans and mice expressing human LDLR.	CHEMBL408967	12-15	low density lipoprotein receptor	Homo sapiens	81-85
30978553-5	2019	RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group.	CHEMBL408967	149-152	tumor necrosis factor	Rattus norvegicus	90-98
30978553-5	2019	RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group.	CHEMBL408967	149-152	TNF superfamily member 11	Rattus norvegicus	100-105
30978553-5	2019	RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group.	CHEMBL408967	149-152	colony stimulating factor 1	Rattus norvegicus	111-115
31031584-8	2019	In this review, we summarize how TDP-43 CTFs are generated and degraded by cells, and critique evidence from studies of TDP-43 CTF pathology in human disease tissues, as well as cell and animal models, to analyze the pathophysiological relevance of TDP-43 CTFs to ALS and FTLD.	CHEMBL408967	40-43	TAR DNA binding protein	Homo sapiens	33-39
27641444-2	2018	Recent data indicate that the CTF can be substantially increased by a cramp training consisting of electrically induced muscle cramps (EIMCs).	CHEMBL408967	30-33	cathelicidin antimicrobial peptide	Homo sapiens	70-75
30206934-5	2019	Here, we demonstrated that continuously applied CTF for only the first 6 hr stimulated the synthesis of BMP9 and induced mineral deposition within 14 days by human PDL cells.	CHEMBL408967	48-51	growth differentiation factor 2	Homo sapiens	104-108
30206934-7	2019	Apyrase, an ecto-ATPase, inhibited CTF-mediated ATP-induced BMP9 expression.	CHEMBL408967	35-38	growth differentiation factor 2	Homo sapiens	60-64
30206934-11	2019	A neutralizing anti-BMP9 antibody decreased mineral deposition, which was stimulated by CTF for almost 45% indicating a role of BMP9 in an in vitro mineralization.	CHEMBL408967	88-91	growth differentiation factor 2	Homo sapiens	20-24
30206934-11	2019	A neutralizing anti-BMP9 antibody decreased mineral deposition, which was stimulated by CTF for almost 45% indicating a role of BMP9 in an in vitro mineralization.	CHEMBL408967	88-91	growth differentiation factor 2	Homo sapiens	128-132
27641444-3	2018	This study investigated if four cramp training sessions induce sustained effects on the CTF.	CHEMBL408967	88-91	cathelicidin antimicrobial peptide	Homo sapiens	32-37
27641444-6	2018	RESULTS: After four cramp training sessions (2 weeks) the CTF differed (p < 0.001) from pre-values in the IL (pre: 19.2 +- 1.4 Hz post 29.8 +- 8.0 Hz) but not in the CL (pre: 18.2 +- 1.5 Hz post 19.6 +- 2.8 Hz; p > 0.05).	CHEMBL408967	58-61	cathelicidin antimicrobial peptide	Homo sapiens	20-25
27641444-8	2018	CONCLUSION: The applied cramp training induced a long-term CTF increase of 14 days.	CHEMBL408967	59-62	cathelicidin antimicrobial peptide	Homo sapiens	24-29
27733037-6	2016	Knockout (KO) of the gene encoding calponin 2 (Cnn2) in mice increased cell motility, suggesting a function of calponin 2 in modulating CTF.	CHEMBL408967	136-139	calponin 2	Mus musculus	35-45
29694352-6	2018	Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group.	CHEMBL408967	129-132	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	45-50
29694352-6	2018	Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group.	CHEMBL408967	129-132	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	52-57
29694352-6	2018	Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group.	CHEMBL408967	129-132	interleukin 1 beta	Rattus norvegicus	59-67
29694352-6	2018	Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group.	CHEMBL408967	129-132	tumor necrosis factor	Rattus norvegicus	69-78
29694352-6	2018	Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group.	CHEMBL408967	129-132	TNF superfamily member 11	Rattus norvegicus	80-85
29694352-6	2018	Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group.	CHEMBL408967	129-132	colony stimulating factor 1	Rattus norvegicus	90-95
29448143-4	2018	As revealed, FN on substrates with low Fad is more liable to be desorbed by CTF, which prevents the transmission of CTF to substrates.	CHEMBL408967	76-79	fibronectin 1	Rattus norvegicus	13-15
29448143-4	2018	As revealed, FN on substrates with low Fad is more liable to be desorbed by CTF, which prevents the transmission of CTF to substrates.	CHEMBL408967	116-119	fibronectin 1	Rattus norvegicus	13-15
29448143-5	2018	In contrast, high Fad facilitates the transmission of CTF from rMSCs to the FN layer and PDMS substrates so that rMSCs can perceive the mechanical properties of substrates.	CHEMBL408967	54-57	fibronectin 1	Rattus norvegicus	76-78
28573374-10	2017	CONCLUSION: Our data indicate that orally administered TRPV1 and TRPA1 activators exert a small short-term effect on the CTF, but not on the other parameters tested.	CHEMBL408967	121-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-60
28573374-10	2017	CONCLUSION: Our data indicate that orally administered TRPV1 and TRPA1 activators exert a small short-term effect on the CTF, but not on the other parameters tested.	CHEMBL408967	121-124	transient receptor potential cation channel subfamily A member 1	Homo sapiens	65-70
30120199-7	2018	Thus, Lys-408 ubiquitinylation appears to hinder Ser-409/410 phosphorylation in TDP-43 CTF.	CHEMBL408967	87-90	TAR DNA binding protein	Homo sapiens	80-86
27733037-6	2016	Knockout (KO) of the gene encoding calponin 2 (Cnn2) in mice increased cell motility, suggesting a function of calponin 2 in modulating CTF.	CHEMBL408967	136-139	calponin 2	Mus musculus	47-51
27733037-6	2016	Knockout (KO) of the gene encoding calponin 2 (Cnn2) in mice increased cell motility, suggesting a function of calponin 2 in modulating CTF.	CHEMBL408967	136-139	calponin 2	Mus musculus	111-121
27733037-10	2016	Adherent calponin 2-null fibroblasts de-adhered faster than the WT control during mild trypsin treatment, consistent with an increased CTF.	CHEMBL408967	135-138	calponin 2	Mus musculus	9-19
27659669-10	2016	RESULTS: Blots of NSE were successful in 14/15 patients, and all 14 (100 %) had a 35-kD CTF of e-cad, while CTFs were absent in healthy control tissues.	CHEMBL408967	88-91	cadherin 1	Homo sapiens	95-100
25720379-5	2015	Whereas the p75(NTR) carboxy terminal fragment (CTF) was more abundant than the intracellular domain (ICD) in HCNs, CGNs exhibited fully processed ICD with very little CTF.	CHEMBL408967	48-51	TNF receptor superfamily member 1B	Homo sapiens	12-15
25720379-5	2015	Whereas the p75(NTR) carboxy terminal fragment (CTF) was more abundant than the intracellular domain (ICD) in HCNs, CGNs exhibited fully processed ICD with very little CTF.	CHEMBL408967	48-51	neurotensin receptor 1	Homo sapiens	16-19
25695270-3	2015	SC myelination requires the adhesion G protein-coupled receptor GPR126, which undergoes autoproteolytic cleavage into an N-terminal fragment (NTF) and a seven-transmembrane-containing C-terminal fragment (CTF).	CHEMBL408967	205-208	adhesion G protein-coupled receptor G6	Homo sapiens	64-70
25174588-9	2014	We conclude that GPS proteolysis and the functional interplay between the NTF and the CTF are indispensible for CD97 to inhibit HT1080 cell migration by suppressing matrix metalloproteinase activity.	CHEMBL408967	86-89	adhesion G protein-coupled receptor E5	Homo sapiens	112-116
25082749-5	2014	RESULTS: CTF produced a dose-dependent increase in DNA synthesis and cell proliferation in human VSMC, which was blocked in a dose-dependent manner by both plasmin inhibitors and the EGFR inhibitor, AG1478.	CHEMBL408967	9-12	plasminogen	Homo sapiens	156-163
25082749-5	2014	RESULTS: CTF produced a dose-dependent increase in DNA synthesis and cell proliferation in human VSMC, which was blocked in a dose-dependent manner by both plasmin inhibitors and the EGFR inhibitor, AG1478.	CHEMBL408967	9-12	epidermal growth factor receptor	Homo sapiens	183-187
25082749-6	2014	CTF induced time-dependent EGFR phosphorylation, which was blocked by inhibitors of plasmin and metalloproteinases activity.	CHEMBL408967	0-3	epidermal growth factor receptor	Homo sapiens	27-31
25082749-6	2014	CTF induced time-dependent EGFR phosphorylation, which was blocked by inhibitors of plasmin and metalloproteinases activity.	CHEMBL408967	0-3	plasminogen	Homo sapiens	84-91
25082749-8	2014	Inhibition of ADAM-10 and -12, and of HB-EGF blocked EGFR activation in response to CTF.	CHEMBL408967	84-87	heparin binding EGF like growth factor	Homo sapiens	38-44
25082749-8	2014	Inhibition of ADAM-10 and -12, and of HB-EGF blocked EGFR activation in response to CTF.	CHEMBL408967	84-87	epidermal growth factor receptor	Homo sapiens	53-57
25082749-9	2014	CTF-mediated activation of EGFR was mediated through Gbetagamma, src, and NAD(P)H oxidase.	CHEMBL408967	0-3	epidermal growth factor receptor	Homo sapiens	27-31
25082749-9	2014	CTF-mediated activation of EGFR was mediated through Gbetagamma, src, and NAD(P)H oxidase.	CHEMBL408967	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-68