PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 19357348-7 2009 Also, we demonstrate that the lack of endogenous Wwox in MDA-MB231 cells represented a molecular mechanism for intranuclear Met-CTF accumulation and for the decrease of full-length Met stability. CHEMBL408967 128-131 WW domain containing oxidoreductase Homo sapiens 49-53 19522733-2 2009 We demonstrate that TDP-43 can be proteolytically processed by caspases upon induction of apoptosis to a major 35 kDa and a minor 25 kDa CTF. CHEMBL408967 137-140 TAR DNA binding protein Homo sapiens 20-26 19524299-7 2009 Here, we demonstrate that two membrane-tethered CD21 CTFs of 8 and 16kDa are constitutively present in human B cells, while only the 8kDa CTF was detectable in murine B cells. CHEMBL408967 53-56 complement C3d receptor 2 Homo sapiens 48-52 15935913-0 2005 ACE: automated CTF estimation. CHEMBL408967 15-18 angiotensin I converting enzyme Homo sapiens 0-3 17150042-6 2007 To show that the HLA-A2 CTF is subsequently cleaved by PS1/gamma-secretase, we re-duced its activity in cell lines stably expressing HLA-A2 and in Jurkat T-cells expressing endogenous MHC I. CHEMBL408967 24-27 presenilin 1 Homo sapiens 55-58 18495341-8 2009 It illuminates that this model is reliable to optimize the adsorption process and CTF is suitable for adsorbing Pb(II) from aqueous solution. CHEMBL408967 82-85 submaxillary gland androgen regulated protein 3B Homo sapiens 112-118 17311707-5 2007 The CTF corresponds to a PSF with a full-width at half-maximum (FWHM) of 130 nm. CHEMBL408967 4-7 insulin like growth factor binding protein 7 Homo sapiens 25-28 16440311-4 2006 We now report that, in conjunction with CTF formation, collagen type I stimulates concentration-dependent, saturable shedding of the DDR1 ectodomain from two carcinoma cell lines, and from transfected cells. CHEMBL408967 40-43 discoidin domain receptor tyrosine kinase 1 Homo sapiens 133-137 16440311-8 2006 The hydroxamate-based metalloproteinase inhibitor TAPI-1 (tumor necrosis factor-alpha protease inhibitor-1), and tissue inhibitor of metalloproteinase (TIMP)-3, also blocked collagen-evoked DDR1 shedding, but did not reduce levels of the phosphorylated CTF. CHEMBL408967 253-256 discoidin domain receptor tyrosine kinase 1 Homo sapiens 190-194 16440311-10 2006 The results demonstrate that collagen-evoked ectodomain cleavage of DDR1 is mediated in part by Src-dependent activation or recruitment of a matrix- or disintegrin metalloproteinase, and that CTF formation can occur independently of ectodomain shedding. CHEMBL408967 192-195 discoidin domain receptor tyrosine kinase 1 Homo sapiens 68-72 15975090-6 2005 Using wild-type HEK-293 cells (human embryonic kidney 293 cells) and PS-inducible cells, we now show that overexpression of either ubiquilin-1 or -2 decreases the PS NTF and CTF levels. CHEMBL408967 174-177 ubiquilin 1 Homo sapiens 131-148 15975090-7 2005 Conversely, siRNA (small interfering RNA)-mediated knockdown of ubiquilin-1 and -2 proteins increased the PS NTF and CTF levels. CHEMBL408967 117-120 ubiquilin 1 Homo sapiens 64-82 14527729-7 2003 Human PS1 CTF exogenously injected was also phosphorylated in Xenopus oocytes induced to mature in vitro by progesterone treatment. CHEMBL408967 10-13 presenilin 1 Homo sapiens 6-9 15659814-7 2004 Our result show that the APP, CTF, and ShcA interaction is induced only upon overexpression of BACE1 either transiently or in stable cell lines. CHEMBL408967 30-33 beta-secretase 1 Homo sapiens 95-100 12903398-4 2000 The interaction site between domains within PS1 located at amino acid 361-447 of PS1 CTF, without the involvement of other partners. CHEMBL408967 85-88 presenilin 1 Homo sapiens 44-47 11278424-12 2001 Interestingly, when the 25-kDa PS2 CTF and the 20-kDa PS2 CTF are both present, calsenilin preferentially interacts with the 20-kDa CTF. CHEMBL408967 35-38 presenilin 2 Homo sapiens 31-34 11278424-12 2001 Interestingly, when the 25-kDa PS2 CTF and the 20-kDa PS2 CTF are both present, calsenilin preferentially interacts with the 20-kDa CTF. CHEMBL408967 35-38 potassium voltage-gated channel interacting protein 3 Homo sapiens 80-90 11731004-4 2001 Interestingly, the phosphorylation of PS2 modulates the production of the smaller, caspase-derived PS2 CTF, which indicates that the generation of this fragment is a regulated, physiologic event. CHEMBL408967 103-106 presenilin 2 Homo sapiens 38-41 11731004-4 2001 Interestingly, the phosphorylation of PS2 modulates the production of the smaller, caspase-derived PS2 CTF, which indicates that the generation of this fragment is a regulated, physiologic event. CHEMBL408967 103-106 presenilin 2 Homo sapiens 99-102 11585344-5 2001 The proform or the CTF portion of OIP-2 inhibited OCL formation in a dose-dependent manner in murine bone marrow cultures stimulated with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. CHEMBL408967 19-22 occludin Mus musculus 50-53 12903398-4 2000 The interaction site between domains within PS1 located at amino acid 361-447 of PS1 CTF, without the involvement of other partners. CHEMBL408967 85-88 presenilin 1 Homo sapiens 81-84 10220591-4 1999 Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9. CHEMBL408967 30-33 interleukin 1 alpha Homo sapiens 60-73 10561499-3 1999 We found that expression of CTF markedly increased, similarly to the intact protein, JNK dephosphorylation in heat-shocked cells. CHEMBL408967 28-31 mitogen-activated protein kinase 8 Homo sapiens 85-88 10220591-4 1999 Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9. CHEMBL408967 30-33 interleukin 1 alpha Homo sapiens 75-79 10220591-4 1999 Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9. CHEMBL408967 30-33 matrix metallopeptidase 2 Homo sapiens 82-121 10220591-4 1999 Fifteen kPa of high frequency CTF induced the expression of interleukin-1 (IL-1), matrix metalloproteinase (MMP)-2 and -9 mRNA, and increased the production of pro- and active-MMP-9. CHEMBL408967 30-33 matrix metallopeptidase 9 Homo sapiens 176-181 10220591-5 1999 The degradation of proteoglycan was inhibited by and MMP inhibitor, indicating that MMPs are involved in the degradation of proteoglycans induced by high frequency CTF. CHEMBL408967 164-167 matrix metallopeptidase 2 Homo sapiens 84-88 10220591-9 1999 High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation. CHEMBL408967 29-32 interleukin 1 alpha Homo sapiens 63-67 10220591-9 1999 High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation. CHEMBL408967 29-32 matrix metallopeptidase 9 Homo sapiens 72-77 10220591-9 1999 High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation. CHEMBL408967 29-32 matrix metallopeptidase 2 Homo sapiens 122-134 10220591-9 1999 High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation. CHEMBL408967 29-32 interleukin 1 alpha Homo sapiens 237-241 10220591-9 1999 High magnitude and frequency CTF caused the gene expression of IL-1 and MMP-9, followed by increases in the production of MMP-2 and -9 proteins, suggesting that excessive and continuous cyclic mechanical stress induces the production of IL-1 and MMP-9, resulting in cartilage degradation. CHEMBL408967 29-32 matrix metallopeptidase 9 Homo sapiens 246-251 8803927-10 1996 Moreover, we observed that the binding activities of TFIID, CTF, and binding proteins to -40, -120 and -260 regions increased. CHEMBL408967 60-63 TATA-box binding protein Homo sapiens 53-58 9507053-10 1998 In dMEA and CTF, nuclear colocalization of AR-ir and mating-induced Fos-ir was present in a proportion of FG-containing neurons. CHEMBL408967 12-15 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 68-71 9144195-3 1997 Using COS7 cells transfected with human PS1, we have found that phorbol 12, 13-dibutyrate and forskolin increase the state of phosphorylation of serine residues of the human CTF. CHEMBL408967 174-177 presenilin 1 Homo sapiens 40-43 9144195-8 1997 Upon phosphorylation of the PS1 CTF, the apparent mass of the NTF- or CTF-containing oligomers was unchanged. CHEMBL408967 32-35 presenilin 1 Homo sapiens 28-31 9990034-5 1999 Recently, we found that the CTF of PS-2 is phosphorylated in vivo. CHEMBL408967 28-31 presenilin 2 Homo sapiens 35-39 9144240-6 1997 Stimulation of PKC causes a 4- to 5-fold increase of the phosphorylation of the approximately 20-kDa CTF of PS-1 resulting in reduced mobility in SDS gels. CHEMBL408967 101-104 proline rich transmembrane protein 2 Homo sapiens 15-18 9144240-6 1997 Stimulation of PKC causes a 4- to 5-fold increase of the phosphorylation of the approximately 20-kDa CTF of PS-1 resulting in reduced mobility in SDS gels. CHEMBL408967 101-104 presenilin 1 Homo sapiens 108-112 7529108-9 1994 For thermolysin the relative rates of hydrolysis were found to be big ET-1 > CTF > ET-1. CHEMBL408967 80-83 endothelin 1 Homo sapiens 70-74 7529108-9 1994 For thermolysin the relative rates of hydrolysis were found to be big ET-1 > CTF > ET-1. CHEMBL408967 80-83 endothelin 1 Homo sapiens 89-93 7529108-18 1994 Both ET-l-like and CTF-like peaks were detected at 214 nm when the products of big ET-1 hydrolysis by thermolysin were resolved by h.p.l.c. CHEMBL408967 19-22 endothelin 1 Homo sapiens 83-87 31744884-9 2020 Dp44mT and a gamma-secretase inhibitor increased cellular c-Met CTF levels, suggesting that Dp44mT induces c-Met CTF levels by increasing metalloprotease activity. CHEMBL408967 64-67 MET proto-oncogene, receptor tyrosine kinase Homo sapiens 58-63 35475353-5 2022 It was found that sulfur-doped CTF (S-CTF-1) showed a 25.6-fold increase in saturated adsorption capacity (554.7 mumol/g) and a 169.0-fold surge in photocatalytic kinetics (5.07 h-1), respectively, compared with the pristine CTF-1. CHEMBL408967 31-34 cardiotrophin 1 Homo sapiens 225-230 33389205-2 2021 The microporous CTF with fluorene backbone was coupled and grown uniformly on the surface of phenyl-functionalized KCC-1 to prepare a hybrid extended porous framework. CHEMBL408967 16-19 solute carrier family 12 member 4 Homo sapiens 115-120 2182023-1 1990 We designed a radioimmunoassay (RIA) specific for the C-terminal fragment (CTF, 22-39) of porcine big endothelin-1 (big ET-1, 1-39), and investigated whether the generation of ET-1 (1-21) is concomitant with that of the CTF during incubation of big ET-1 with the endothelial cell (EC)-extract. CHEMBL408967 75-78 endothelin 1 Homo sapiens 102-114 35414534-7 2022 Specifically, APOER2 isoforms lacking exons 5-8 (Deltaex5-8) and lacking exons 4-6 (Deltaex4-6) generated the highest and lowest amounts of CTF generation, respectively in response to APOE peptide compared to APOER2-FL. CHEMBL408967 140-143 LDL receptor related protein 8 Homo sapiens 14-20 35414534-7 2022 Specifically, APOER2 isoforms lacking exons 5-8 (Deltaex5-8) and lacking exons 4-6 (Deltaex4-6) generated the highest and lowest amounts of CTF generation, respectively in response to APOE peptide compared to APOER2-FL. CHEMBL408967 140-143 apolipoprotein E Homo sapiens 184-188 35414534-7 2022 Specifically, APOER2 isoforms lacking exons 5-8 (Deltaex5-8) and lacking exons 4-6 (Deltaex4-6) generated the highest and lowest amounts of CTF generation, respectively in response to APOE peptide compared to APOER2-FL. CHEMBL408967 140-143 LDL receptor related protein 8 Homo sapiens 209-215 3757032-4 1986 I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF. CHEMBL408967 50-53 heat shock factor protein Xenopus laevis 70-101 3757032-4 1986 I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF. CHEMBL408967 50-53 heat shock factor protein Xenopus laevis 103-107 3757032-4 1986 I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF. CHEMBL408967 50-53 heat shock factor protein Xenopus laevis 144-148 3757032-4 1986 I propose that CAAT-binding transcription factor (CTF) interacts with heat shock transcription factor (HSTF), thereby enhancing the affinity of HSTF for the promoter; cell-type specificity could be explained by assuming either oocyte-specific forms or oocyte-specific high levels of CTF and/or HSTF. CHEMBL408967 50-53 heat shock factor protein Xenopus laevis 144-148 31744884-9 2020 Dp44mT and a gamma-secretase inhibitor increased cellular c-Met CTF levels, suggesting that Dp44mT induces c-Met CTF levels by increasing metalloprotease activity. CHEMBL408967 64-67 MET proto-oncogene, receptor tyrosine kinase Homo sapiens 107-112 31441220-2 2019 The high-PF6 - -content CTF shows the CO2 adsorption of 44.7 cm3 g-1 and I2 capture capacity of 312 wt %. CHEMBL408967 24-27 sperm associated antigen 17 Homo sapiens 9-12 31377584-3 2019 It is unknown whether CTF-induced IL6 regulates the expression of MMPs, enzymes needed for tissue remodeling. CHEMBL408967 22-25 interleukin 6 Homo sapiens 34-37 31377584-3 2019 It is unknown whether CTF-induced IL6 regulates the expression of MMPs, enzymes needed for tissue remodeling. CHEMBL408967 22-25 matrix metallopeptidase 3 Homo sapiens 66-70 31377584-5 2019 Using a neutralizing anti-IL6 antibody and addition of recombinant human IL6 at concentrations of 0.1, 1, 10 ng.mL-1 were performed to clarify whether CTF-upregulated IL6 increased MMP expression. CHEMBL408967 151-154 interleukin 6 Homo sapiens 26-29 31377584-10 2019 CONCLUSION: Our findings suggest a role of CTF in the modulation of expression of IL6 and MMP3 and thus in the regulation of homeostasis and remodeling of the periodontal ligament. CHEMBL408967 43-46 interleukin 6 Homo sapiens 82-85 31377584-10 2019 CONCLUSION: Our findings suggest a role of CTF in the modulation of expression of IL6 and MMP3 and thus in the regulation of homeostasis and remodeling of the periodontal ligament. CHEMBL408967 43-46 matrix metallopeptidase 3 Homo sapiens 90-94 31388055-5 2019 Pharmacological inhibition of BMP1 or siRNA-mediated knockdown prevented the generation of the 120 kDa CTF and resulted in an increase in LDL uptake into cells. CHEMBL408967 103-106 bone morphogenetic protein 1 Homo sapiens 30-34 31358631-3 2019 We studied this complex for dynamic conformational changes 1) at low and high [Ca2+] (pCa 9.0 and 4.5), and 2) upon myosin binding to the cTF in the nucleotide-free state or in the presence of ATP. CHEMBL408967 138-141 myosin heavy chain 14 Homo sapiens 116-122 31358631-6 2019 The weakly and strongly bound myosin induce similar changes in the structure of cTFs as confirmed by the local dynamical displacement of individual tropomyosin strands in the center of a regulatory unit of cTF at the relaxed and activation conditions. CHEMBL408967 80-83 myosin heavy chain 14 Homo sapiens 30-36 31264863-4 2019 Benefiting from these defects, the adsorption sites with high energy for adsorbing volatile aromatic pollutants were significantly increased, which are reflected by higher saturated adsorption capacities of CTF-m (3.026 mmol/g for benzene (BEN), 1.490 mmol/g for naphthalene (NAP), and 0.863 mmol/g for phenol (PHE)) compared with those of CTF-1 and CTF-2. CHEMBL408967 207-210 cardiotrophin 1 Homo sapiens 340-345 31388055-6 2019 The 120 kDa CTF was detected in the livers from humans and mice expressing human LDLR. CHEMBL408967 12-15 low density lipoprotein receptor Homo sapiens 81-85 31031584-8 2019 In this review, we summarize how TDP-43 CTFs are generated and degraded by cells, and critique evidence from studies of TDP-43 CTF pathology in human disease tissues, as well as cell and animal models, to analyze the pathophysiological relevance of TDP-43 CTFs to ALS and FTLD. CHEMBL408967 40-43 TAR DNA binding protein Homo sapiens 33-39 30978553-5 2019 RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group. CHEMBL408967 149-152 interleukin 1 beta Rattus norvegicus 83-88 30978553-5 2019 RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group. CHEMBL408967 149-152 tumor necrosis factor Rattus norvegicus 90-98 30978553-5 2019 RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group. CHEMBL408967 149-152 TNF superfamily member 11 Rattus norvegicus 100-105 30978553-5 2019 RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group. CHEMBL408967 149-152 colony stimulating factor 1 Rattus norvegicus 111-115 30206934-5 2019 Here, we demonstrated that continuously applied CTF for only the first 6 hr stimulated the synthesis of BMP9 and induced mineral deposition within 14 days by human PDL cells. CHEMBL408967 48-51 growth differentiation factor 2 Homo sapiens 104-108 30206934-7 2019 Apyrase, an ecto-ATPase, inhibited CTF-mediated ATP-induced BMP9 expression. CHEMBL408967 35-38 growth differentiation factor 2 Homo sapiens 60-64 30206934-11 2019 A neutralizing anti-BMP9 antibody decreased mineral deposition, which was stimulated by CTF for almost 45% indicating a role of BMP9 in an in vitro mineralization. CHEMBL408967 88-91 growth differentiation factor 2 Homo sapiens 20-24 30206934-11 2019 A neutralizing anti-BMP9 antibody decreased mineral deposition, which was stimulated by CTF for almost 45% indicating a role of BMP9 in an in vitro mineralization. CHEMBL408967 88-91 growth differentiation factor 2 Homo sapiens 128-132 30120199-7 2018 Thus, Lys-408 ubiquitinylation appears to hinder Ser-409/410 phosphorylation in TDP-43 CTF. CHEMBL408967 87-90 TAR DNA binding protein Homo sapiens 80-86 27641444-2 2018 Recent data indicate that the CTF can be substantially increased by a cramp training consisting of electrically induced muscle cramps (EIMCs). CHEMBL408967 30-33 cathelicidin antimicrobial peptide Homo sapiens 70-75 27641444-3 2018 This study investigated if four cramp training sessions induce sustained effects on the CTF. CHEMBL408967 88-91 cathelicidin antimicrobial peptide Homo sapiens 32-37 27641444-6 2018 RESULTS: After four cramp training sessions (2 weeks) the CTF differed (p < 0.001) from pre-values in the IL (pre: 19.2 +- 1.4 Hz post 29.8 +- 8.0 Hz) but not in the CL (pre: 18.2 +- 1.5 Hz post 19.6 +- 2.8 Hz; p > 0.05). CHEMBL408967 58-61 cathelicidin antimicrobial peptide Homo sapiens 20-25 27641444-8 2018 CONCLUSION: The applied cramp training induced a long-term CTF increase of 14 days. CHEMBL408967 59-62 cathelicidin antimicrobial peptide Homo sapiens 24-29 25695270-3 2015 SC myelination requires the adhesion G protein-coupled receptor GPR126, which undergoes autoproteolytic cleavage into an N-terminal fragment (NTF) and a seven-transmembrane-containing C-terminal fragment (CTF). CHEMBL408967 205-208 adhesion G protein-coupled receptor G6 Homo sapiens 64-70 29694352-6 2018 Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group. CHEMBL408967 129-132 cytochrome c oxidase I, mitochondrial Rattus norvegicus 45-50 29694352-6 2018 Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group. CHEMBL408967 129-132 cytochrome c oxidase II, mitochondrial Rattus norvegicus 52-57 29694352-6 2018 Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group. CHEMBL408967 129-132 interleukin 1 beta Rattus norvegicus 59-67 29694352-6 2018 Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group. CHEMBL408967 129-132 tumor necrosis factor Rattus norvegicus 69-78 29694352-6 2018 Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group. CHEMBL408967 129-132 TNF superfamily member 11 Rattus norvegicus 80-85 29694352-6 2018 Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group. CHEMBL408967 129-132 colony stimulating factor 1 Rattus norvegicus 90-95 29448143-4 2018 As revealed, FN on substrates with low Fad is more liable to be desorbed by CTF, which prevents the transmission of CTF to substrates. CHEMBL408967 76-79 fibronectin 1 Rattus norvegicus 13-15 29448143-4 2018 As revealed, FN on substrates with low Fad is more liable to be desorbed by CTF, which prevents the transmission of CTF to substrates. CHEMBL408967 116-119 fibronectin 1 Rattus norvegicus 13-15 29448143-5 2018 In contrast, high Fad facilitates the transmission of CTF from rMSCs to the FN layer and PDMS substrates so that rMSCs can perceive the mechanical properties of substrates. CHEMBL408967 54-57 fibronectin 1 Rattus norvegicus 76-78 25720379-5 2015 Whereas the p75(NTR) carboxy terminal fragment (CTF) was more abundant than the intracellular domain (ICD) in HCNs, CGNs exhibited fully processed ICD with very little CTF. CHEMBL408967 48-51 TNF receptor superfamily member 1B Homo sapiens 12-15 25720379-5 2015 Whereas the p75(NTR) carboxy terminal fragment (CTF) was more abundant than the intracellular domain (ICD) in HCNs, CGNs exhibited fully processed ICD with very little CTF. CHEMBL408967 48-51 neurotensin receptor 1 Homo sapiens 16-19 28573374-10 2017 CONCLUSION: Our data indicate that orally administered TRPV1 and TRPA1 activators exert a small short-term effect on the CTF, but not on the other parameters tested. CHEMBL408967 121-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 55-60 28573374-10 2017 CONCLUSION: Our data indicate that orally administered TRPV1 and TRPA1 activators exert a small short-term effect on the CTF, but not on the other parameters tested. CHEMBL408967 121-124 transient receptor potential cation channel subfamily A member 1 Homo sapiens 65-70 27733037-6 2016 Knockout (KO) of the gene encoding calponin 2 (Cnn2) in mice increased cell motility, suggesting a function of calponin 2 in modulating CTF. CHEMBL408967 136-139 calponin 2 Mus musculus 35-45 27733037-6 2016 Knockout (KO) of the gene encoding calponin 2 (Cnn2) in mice increased cell motility, suggesting a function of calponin 2 in modulating CTF. CHEMBL408967 136-139 calponin 2 Mus musculus 47-51 27733037-6 2016 Knockout (KO) of the gene encoding calponin 2 (Cnn2) in mice increased cell motility, suggesting a function of calponin 2 in modulating CTF. CHEMBL408967 136-139 calponin 2 Mus musculus 111-121 27733037-10 2016 Adherent calponin 2-null fibroblasts de-adhered faster than the WT control during mild trypsin treatment, consistent with an increased CTF. CHEMBL408967 135-138 calponin 2 Mus musculus 9-19 27659669-10 2016 RESULTS: Blots of NSE were successful in 14/15 patients, and all 14 (100 %) had a 35-kD CTF of e-cad, while CTFs were absent in healthy control tissues. CHEMBL408967 88-91 cadherin 1 Homo sapiens 95-100 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 187-190 polycystin 1, transient receptor potential channel interacting Mus musculus 70-73 25082749-5 2014 RESULTS: CTF produced a dose-dependent increase in DNA synthesis and cell proliferation in human VSMC, which was blocked in a dose-dependent manner by both plasmin inhibitors and the EGFR inhibitor, AG1478. CHEMBL408967 9-12 plasminogen Homo sapiens 156-163 25082749-5 2014 RESULTS: CTF produced a dose-dependent increase in DNA synthesis and cell proliferation in human VSMC, which was blocked in a dose-dependent manner by both plasmin inhibitors and the EGFR inhibitor, AG1478. CHEMBL408967 9-12 epidermal growth factor receptor Homo sapiens 183-187 25082749-6 2014 CTF induced time-dependent EGFR phosphorylation, which was blocked by inhibitors of plasmin and metalloproteinases activity. CHEMBL408967 0-3 epidermal growth factor receptor Homo sapiens 27-31 25082749-6 2014 CTF induced time-dependent EGFR phosphorylation, which was blocked by inhibitors of plasmin and metalloproteinases activity. CHEMBL408967 0-3 plasminogen Homo sapiens 84-91 25082749-8 2014 Inhibition of ADAM-10 and -12, and of HB-EGF blocked EGFR activation in response to CTF. CHEMBL408967 84-87 heparin binding EGF like growth factor Homo sapiens 38-44 25082749-8 2014 Inhibition of ADAM-10 and -12, and of HB-EGF blocked EGFR activation in response to CTF. CHEMBL408967 84-87 epidermal growth factor receptor Homo sapiens 53-57 25082749-9 2014 CTF-mediated activation of EGFR was mediated through Gbetagamma, src, and NAD(P)H oxidase. CHEMBL408967 0-3 epidermal growth factor receptor Homo sapiens 27-31 25082749-9 2014 CTF-mediated activation of EGFR was mediated through Gbetagamma, src, and NAD(P)H oxidase. CHEMBL408967 0-3 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 65-68 25174588-9 2014 We conclude that GPS proteolysis and the functional interplay between the NTF and the CTF are indispensible for CD97 to inhibit HT1080 cell migration by suppressing matrix metalloproteinase activity. CHEMBL408967 86-89 adhesion G protein-coupled receptor E5 Homo sapiens 112-116 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 187-190 polycystin 1, transient receptor potential channel interacting Mus musculus 75-83 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 187-190 polycystin 1, transient receptor potential channel interacting Mus musculus 75-78 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 187-190 polycystin 1, transient receptor potential channel interacting Mus musculus 75-78 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 266-269 polycystin 1, transient receptor potential channel interacting Mus musculus 70-73 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 266-269 polycystin 1, transient receptor potential channel interacting Mus musculus 75-83 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 266-269 polycystin 1, transient receptor potential channel interacting Mus musculus 75-78 24958103-3 2014 GPS cleavage generates not only the heterodimeric cleaved full-length Pc1 (Pc1(cFL)) in which the N-terminal fragment (NTF) remains noncovalently associated with the C-terminal fragment (CTF) but also a novel (Pc1) form (Pc1(deN)) in which NTF becomes detached from CTF. CHEMBL408967 266-269 polycystin 1, transient receptor potential channel interacting Mus musculus 75-78 24958103-7 2014 By functional genetic complementation with five Pkd1 mouse models, we discovered that CTF plays a crucial role in Pc1(deN) trafficking. CHEMBL408967 86-89 polycystin 1, transient receptor potential channel interacting Mus musculus 48-52 24958103-7 2014 By functional genetic complementation with five Pkd1 mouse models, we discovered that CTF plays a crucial role in Pc1(deN) trafficking. CHEMBL408967 86-89 polycystin 1, transient receptor potential channel interacting Mus musculus 114-117 24705369-7 2014 The reduction of SNX17 was associated with accumulation of an ApoER2 carboxy-terminal fragment (CTF). CHEMBL408967 96-99 sorting nexin 17 Homo sapiens 17-22 24705369-7 2014 The reduction of SNX17 was associated with accumulation of an ApoER2 carboxy-terminal fragment (CTF). CHEMBL408967 96-99 LDL receptor related protein 8 Homo sapiens 62-68 22399757-5 2012 FBL2 bound with APP specifically at its C-terminal fragment (CTF), which promoted APP/CTF ubiquitination. CHEMBL408967 61-64 F-box and leucine-rich repeat protein 20 Mus musculus 0-4 24103640-9 2013 Co-expression of the CTF and full-length YB-1 resulted in an abrogated transcriptional activation of the MMP-2 promoter, indicating an autoregulatory inhibitory loop, whereas it fulfilled similar trans-repressive effects on the collagen type I promoter. CHEMBL408967 21-24 matrix metallopeptidase 2 Homo sapiens 105-110 24009667-8 2013 Generation of CTF and EpICD fragments and the degradation of hEpICD via the proteasome were similarly demonstrated for the human EpCAM ortholog. CHEMBL408967 14-17 epithelial cell adhesion molecule Homo sapiens 129-134 21946215-4 2011 Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells. CHEMBL408967 160-163 ribonucleotide reductase M2 Mus musculus 70-74 21946215-4 2011 Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells. CHEMBL408967 160-163 TAR DNA binding protein Mus musculus 79-85 21946215-4 2011 Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells. CHEMBL408967 160-163 ribonucleotide reductase M2 Mus musculus 138-142 21946215-4 2011 Truncations were tested mainly within a second RNA recognition motif (RRM2) of TDP-43; when the truncation site was more C-terminal in an RRM2 domain, a TDP-43 CTF basically became less soluble and more phosphorylated in differentiated Neuro2a cells. CHEMBL408967 160-163 TAR DNA binding protein Mus musculus 153-159 21967679-7 2011 The association rate constant (k(a)) of plasma VWF binding at a wall shear stress of 45 dyn/cm(2) was 0.3 x 10(5), 1.8 x 10(5), and 1.6 x 10(5) M(-1) s(-1) for CTF grown from 10, 100, and 1000 mug/mL solutions, respectively. CHEMBL408967 160-163 von Willebrand factor Homo sapiens 47-50 20978202-10 2010 With these antibodies, we showed that, whereas the frequency of ER positivity in HER2-positive/611-CTF-negative tumors (72.6%) is similar to that reported for HER2-negative tumors (70-80%), the number of ER-positive tumors in the 611-CTF-positive subgroup is very low (31.2%). CHEMBL408967 99-102 estrogen receptor 1 Homo sapiens 64-66 20978202-10 2010 With these antibodies, we showed that, whereas the frequency of ER positivity in HER2-positive/611-CTF-negative tumors (72.6%) is similar to that reported for HER2-negative tumors (70-80%), the number of ER-positive tumors in the 611-CTF-positive subgroup is very low (31.2%). CHEMBL408967 234-237 estrogen receptor 1 Homo sapiens 64-66 20043227-5 2010 In the cerebella of six control individuals, the CTF was detected in sucrose- and SDS-soluble cytosolic fractions; in the cerebella of two SCA6 patients, it was additionally detected in SDS-insoluble cytosolic and sucrose-soluble nuclear fractions. CHEMBL408967 49-52 calcium voltage-gated channel subunit alpha1 A Homo sapiens 139-143