PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33925111-5 2021 PGC1alpha overexpression positively affects the activity of Sirtuin 3, a mitochondrial nicotinammide adenina dinucleotide (NAD)-dependent deacetylase, on osteoblastic differentiation. nadide 123-126 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 0-9 33805532-0 2021 NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging. nadide 90-93 nicotinamide riboside kinase 2 Mus musculus 0-5 33805532-3 2021 We used bioinformatics to identify the Nmrk2 gene involved in nicotinamide adenine dinucleotde (NAD) coenzyme biosynthesis as activated in different mouse models and in hearts of human patients with DCM while the Nampt gene controlling a parallel pathway is repressed. nadide 96-99 nicotinamide riboside kinase 2 Mus musculus 39-44 33805532-3 2021 We used bioinformatics to identify the Nmrk2 gene involved in nicotinamide adenine dinucleotde (NAD) coenzyme biosynthesis as activated in different mouse models and in hearts of human patients with DCM while the Nampt gene controlling a parallel pathway is repressed. nadide 96-99 nicotinamide phosphoribosyltransferase Homo sapiens 213-218 33805532-7 2021 Nmrk2-KO mice developed a progressive DCM-like phenotype with aging, associating eccentric remodeling of the left ventricle and a decline in ejection fraction and showed a reduction in myocardial NAD levels at 24 months. nadide 196-199 nicotinamide riboside kinase 2 Mus musculus 0-5 33805532-10 2021 Nmrk2 gene is required to preserve cardiac structure and function, and becomes an important component of the NAD biosynthetic pathways during aging. nadide 109-112 nicotinamide riboside kinase 2 Mus musculus 0-5 34681008-2 2021 The NADSYN1 encodes the final enzyme in the de novo NAD synthesis pathway and, therefore, plays an important role in NAD metabolism and organ embryogenesis. nadide 52-55 NAD synthetase 1 Homo sapiens 4-11 34681008-2 2021 The NADSYN1 encodes the final enzyme in the de novo NAD synthesis pathway and, therefore, plays an important role in NAD metabolism and organ embryogenesis. nadide 117-120 NAD synthetase 1 Homo sapiens 4-11 35441488-1 2022 OBJECTIVE: To observe expression of CD38, a key modulator of nicotinamide dinucleotide (NAD+) metabolism in mice with knee osteoarthritis, and protective effect of CD38 inhibition during the osteoarthritis (OA) development. nadide 61-86 CD38 antigen Mus musculus 36-40 3580021-2 1987 An addition of glutathione, dithiothreitol, nicotinic acid-amide-adenine-dinucleotide (NAD) or its reduced form (NADH) to the ALDH preparations preserved the enzyme activity; the above SH-reagents regenerated an already occurred loss of activity rapidly (within minutes) and almost completely. nadide 87-90 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 126-130 1964035-1 1990 Islet-activating protein (IAP), one of the pertussis toxins, serving [alpha-32P]nicotinamide adenine dinucleotide (NAD) as a substrate for ADP ribosylation, radiolabelled a specific pig epidermal membrane protein. nadide 115-118 CD47 molecule Sus scrofa 0-24 1964035-1 1990 Islet-activating protein (IAP), one of the pertussis toxins, serving [alpha-32P]nicotinamide adenine dinucleotide (NAD) as a substrate for ADP ribosylation, radiolabelled a specific pig epidermal membrane protein. nadide 115-118 CD47 molecule Sus scrofa 26-29 1964035-4 1990 IAP is known to work on intact cell systems resulting in the ADP ribosylation using intracellular NAD as the ADP ribose donor. nadide 98-101 islet amyloid polypeptide Homo sapiens 0-3 33809872-2 2021 Sirtuin-1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD)-dependent histone deacetylase and belongs to the sirtuin family of deacetylases. nadide 60-63 sirtuin 1 Macaca mulatta 0-9 33809872-2 2021 Sirtuin-1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD)-dependent histone deacetylase and belongs to the sirtuin family of deacetylases. nadide 60-63 sirtuin 1 Macaca mulatta 11-16 34069807-5 2021 Here, we will discuss how the structure of the rDNA loci, the nucleolus and the rate of Pol I transcription are important for dynamic regulation of global gene expression and genome stability, e.g., through the modulation of long-range genomic interactions with the suppressive NAD environment. nadide 278-281 DNA polymerase iota Homo sapiens 88-93 35392281-3 2022 MI was detected indirectly by the reaction product of myoinositol dehydrogenase (IDH) and cofactor beta-nicotinamide adenine dinucleotide (NAD+). nadide 99-137 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 81-84 35173156-0 2022 Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA. nadide 52-55 chromatin-binding exonuclease XRN1 Saccharomyces cerevisiae S288C 0-4 35173156-3 2022 Here, we show that the yeast Saccharomyces cerevisiae cytoplasmic 5"-end exoribonuclease Xrn1 is also a NAD cap decapping (deNADding) enzyme that releases intact NAD and subsequently degrades the RNA. nadide 104-107 chromatin-binding exonuclease XRN1 Saccharomyces cerevisiae S288C 89-93 35173156-3 2022 Here, we show that the yeast Saccharomyces cerevisiae cytoplasmic 5"-end exoribonuclease Xrn1 is also a NAD cap decapping (deNADding) enzyme that releases intact NAD and subsequently degrades the RNA. nadide 162-165 chromatin-binding exonuclease XRN1 Saccharomyces cerevisiae S288C 89-93 35173156-5 2022 This mutant reveals Xrn1 deNADding is necessary for normal growth on non-fermenting sugar and is involved in modulating mitochondrial NAD-capped RNA levels and may influence intramitochondrial NAD levels. nadide 134-137 chromatin-binding exonuclease XRN1 Saccharomyces cerevisiae S288C 20-24 35173156-5 2022 This mutant reveals Xrn1 deNADding is necessary for normal growth on non-fermenting sugar and is involved in modulating mitochondrial NAD-capped RNA levels and may influence intramitochondrial NAD levels. nadide 193-196 chromatin-binding exonuclease XRN1 Saccharomyces cerevisiae S288C 20-24 35173156-6 2022 Our findings uncover a contribution of mitochondrial NAD-capped RNAs in overall NAD regulation with the deNADding activity of Xrn1 fulfilling a central role. nadide 53-56 chromatin-binding exonuclease XRN1 Saccharomyces cerevisiae S288C 126-130 35173156-6 2022 Our findings uncover a contribution of mitochondrial NAD-capped RNAs in overall NAD regulation with the deNADding activity of Xrn1 fulfilling a central role. nadide 80-83 chromatin-binding exonuclease XRN1 Saccharomyces cerevisiae S288C 126-130 4024523-4 1985 Reduction of transketolase activity was accompanied by an adaptive; increase in glucose-6-phosphate dehydrogenase activity as well as by a decrease in levels of nicotinamide coenzymes (NAD, NADP) in spleen. nadide 185-188 transketolase Rattus norvegicus 13-26 33925111-5 2021 PGC1alpha overexpression positively affects the activity of Sirtuin 3, a mitochondrial nicotinammide adenina dinucleotide (NAD)-dependent deacetylase, on osteoblastic differentiation. nadide 123-126 sirtuin 3 Mus musculus 60-69 30864528-1 2020 OBJECTIVE: We aimed to determine the therapeutic drug monitoring (TDM) features and the relation to brain-derived neurotropic factor (BDNF) of frequently used new antiepileptic drugs (NAD) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide (LCM). nadide 184-187 brain derived neurotrophic factor Homo sapiens 100-132 33292986-7 2020 There was no relation between CW and respiratory death and cardiovascular death, but in added effects, CW(C1) significantly decreased, the risk of non-accidental death in initial lags (CER C1; NAD; lag;0-2 = -19 (CI; -35, -2)). nadide 193-196 pleiotropic regulator 1 Homo sapiens 103-108 32180563-4 2020 METHODS: Here we report that the oxidoreductase cytochrome b5 reductase 3 (Cyb5r3) links FoxO1 signaling to beta-cell stimulus/secretion coupling by regulating mitochondrial function, reactive oxygen species generation, and nicotinamide actin dysfunction (NAD)/reduced nicotinamide actin dysfunction (NADH) ratios. nadide 256-259 cytochrome b5 reductase 3 Mus musculus 48-73 32180563-4 2020 METHODS: Here we report that the oxidoreductase cytochrome b5 reductase 3 (Cyb5r3) links FoxO1 signaling to beta-cell stimulus/secretion coupling by regulating mitochondrial function, reactive oxygen species generation, and nicotinamide actin dysfunction (NAD)/reduced nicotinamide actin dysfunction (NADH) ratios. nadide 256-259 cytochrome b5 reductase 3 Mus musculus 75-81 32180563-4 2020 METHODS: Here we report that the oxidoreductase cytochrome b5 reductase 3 (Cyb5r3) links FoxO1 signaling to beta-cell stimulus/secretion coupling by regulating mitochondrial function, reactive oxygen species generation, and nicotinamide actin dysfunction (NAD)/reduced nicotinamide actin dysfunction (NADH) ratios. nadide 256-259 forkhead box O1 Mus musculus 89-94 33129841-7 2021 Axon degeneration following both vincristine and bortezomib is mediated by a phylogenetically ancient, genetically encoded axon destruction program that leads to the activation of the Toll-like receptor adaptor SARM1 (sterile alpha and TIR motif containing protein 1) and local decrease of nicotinamide dinucleotide (NAD+). nadide 290-315 sterile alpha and TIR motif containing 1 Homo sapiens 211-216 30864528-1 2020 OBJECTIVE: We aimed to determine the therapeutic drug monitoring (TDM) features and the relation to brain-derived neurotropic factor (BDNF) of frequently used new antiepileptic drugs (NAD) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide (LCM). nadide 184-187 brain derived neurotrophic factor Homo sapiens 134-138 31427887-8 2019 Plasma IL-18, IFN-gamma, and IL-6 levels were significantly higher in the AD group than in the NAD group, and the IL-18 levels were positively correlated with the IFN-gamma and IL-6 levels. nadide 95-98 interleukin 18 Homo sapiens 114-119 31226281-12 2019 Regarding bolus administration, 88.6% with AD and 68.7% with NAD injected the insulin bolus before meals (p < 0.001). nadide 61-64 insulin Homo sapiens 78-85 28160567-2 2017 EwS development is driven by a specific chromosomal translocation resulting in the generation of a chimeric EWS-ETS transcription factor, most frequently EWS-FLI1.Nicotinamide adenine dinucleotide (NAD) is a key metabolite of energy metabolism involved in cellular redox reactions, DNA repair, and in the maintenance of genomic stability. nadide 198-201 EWS RNA binding protein 1 Homo sapiens 0-3 30232618-3 2019 The aim of this study was to assess long-term outcomes of POEM for patients with NAD. nadide 81-84 nephronectin Homo sapiens 58-62 30232618-4 2019 METHODS: Records of 40 consecutive patients undergoing POEM for NAD from May 2011 to January 2016 at a single center were retrospectively reviewed. nadide 64-67 nephronectin Homo sapiens 55-59 30258282-5 2018 Results: Compared with the levels in the NAD group, the Th1, Th9, Th17, Th22, and their transcription factor levels were increased and the Th2, Treg, and their transcription factor levels exhibited a decreasing trend in AD patients. nadide 41-44 negative elongation factor complex member C/D Homo sapiens 56-59 29892221-12 2018 The distribution of AD and NAD differed between the PLM and the PLMR scales (p < 0.0001). nadide 27-30 FXYD domain containing ion transport regulator 1 Homo sapiens 52-55 28772201-3 2017 The ADH entrapped within the MADQUAT that was present on the carbon nanoscaffolds exhibited a high electron exchange capability with the electrode through its cofactor beta-nicotinamide adenine dinucleotide hydrate and beta-nicotinamide adenine dinucleotide reduced disodium salt hydrate (NAD+/NADH) redox reaction. nadide 168-214 aldo-keto reductase family 1 member A1 Homo sapiens 4-7 28677728-2 2017 Nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1), a type of NAD-dependent deacetylase, is involved in multiple biological functions, particularly in anti-apoptosis. nadide 37-40 sirtuin 1 Mus musculus 75-80 28677728-2 2017 Nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1), a type of NAD-dependent deacetylase, is involved in multiple biological functions, particularly in anti-apoptosis. nadide 93-96 sirtuin 1 Mus musculus 75-80 28160567-2 2017 EwS development is driven by a specific chromosomal translocation resulting in the generation of a chimeric EWS-ETS transcription factor, most frequently EWS-FLI1.Nicotinamide adenine dinucleotide (NAD) is a key metabolite of energy metabolism involved in cellular redox reactions, DNA repair, and in the maintenance of genomic stability. nadide 198-201 EWS RNA binding protein 1 Homo sapiens 108-111 28160567-2 2017 EwS development is driven by a specific chromosomal translocation resulting in the generation of a chimeric EWS-ETS transcription factor, most frequently EWS-FLI1.Nicotinamide adenine dinucleotide (NAD) is a key metabolite of energy metabolism involved in cellular redox reactions, DNA repair, and in the maintenance of genomic stability. nadide 198-201 EWS RNA binding protein 1 Homo sapiens 154-162 28160567-3 2017 This study describes targeting nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of NAD synthesis, by FK866 in EwS cells. nadide 107-110 nicotinamide phosphoribosyltransferase Homo sapiens 31-69 28160567-3 2017 This study describes targeting nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of NAD synthesis, by FK866 in EwS cells. nadide 107-110 nicotinamide phosphoribosyltransferase Homo sapiens 71-76 28160567-3 2017 This study describes targeting nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of NAD synthesis, by FK866 in EwS cells. nadide 107-110 EWS RNA binding protein 1 Homo sapiens 134-137 28160567-4 2017 Here we report that blocking NAMPT leads to exhaustive NAD depletion in EwS cells, followed by a metabolic collapse and cell death. nadide 55-58 nicotinamide phosphoribosyltransferase Homo sapiens 29-34 28160567-4 2017 Here we report that blocking NAMPT leads to exhaustive NAD depletion in EwS cells, followed by a metabolic collapse and cell death. nadide 55-58 EWS RNA binding protein 1 Homo sapiens 72-75 28160567-6 2017 Consistent with this finding, a comparison of 7 EwS cell lines of different genotypes with 5 Non-EwS cell lines and mesenchymal stem cells revealed significantly higher FK866 sensitivity of EWS-ETS positive EwS cells, with IC50 values mostly below 1nM.Taken together, our data reveal evidence of an important role of the NAMPT-mediated NAD salvage pathway in the energy homeostasis of EwS cells and suggest NAMPT inhibition as a potential new treatment approach for Ewing sarcoma. nadide 336-339 EWS RNA binding protein 1 Homo sapiens 190-193 24201549-4 2014 RESULTS: The combination of NAD and RT-CAD significantly decreased tumour [C]choline uptake (SUV60,ave, SUV60,max, TMR60,max or Kimod-pat) and prostate-specific antigen (PSA) levels (analysis of variance, P<0.001 for all variables). nadide 28-31 kallikrein related peptidase 3 Homo sapiens 143-174 27231094-5 2016 The NAD localizes to the periphery of the nucleolus and physically associates with Cdc14, the ultimate effector of the mitotic exit network. nadide 4-7 cell division cycle 14A Homo sapiens 83-88 24201549-6 2014 A wide range of reduction in tumour SUV60,ave (38-83.7%) and SUV60,max (22.2-85.3%) was seen with combined NAD and RT-CAD despite patients universally achieving PSA suppression (narrow range of 93.5-99.7%). nadide 107-110 kallikrein related peptidase 3 Homo sapiens 161-164 24201549-8 2014 The reduction in tumour SUV60,ave after NAD was associated with PSA reduction (r=0.7, P=0.04). nadide 40-43 kallikrein related peptidase 3 Homo sapiens 64-67 24201549-11 2014 A differential reduction in [C]choline uptake despite a global reduction in PSA following NAD and RT-CAD could provide prognostic information and warrants further evaluation as an imaging biomarker in this setting. nadide 90-93 kallikrein related peptidase 3 Homo sapiens 76-79 23056490-8 2012 Subsequent comparison of selective epithelial, mesenchymal and cancer stem cell (CSC) markers between AD and NAD populations of CN and CR patients demonstrated an enhanced trend in mRNA expression of E-cadherin, EpCAM, STAT3 and Oct4 in the NAD population of CR patients. nadide 109-112 cadherin 1 Homo sapiens 200-210 22701197-9 2012 ApoE4 allele frequencies were highest among AD with comorbid DM (0.35) followed by AD without DM (0.25), nAD with DM (0.13), nAD without comorbid DM (0.12), and NC (0.08). nadide 105-108 apolipoprotein E Homo sapiens 0-5 22701197-9 2012 ApoE4 allele frequencies were highest among AD with comorbid DM (0.35) followed by AD without DM (0.25), nAD with DM (0.13), nAD without comorbid DM (0.12), and NC (0.08). nadide 125-128 apolipoprotein E Homo sapiens 0-5 21925214-6 2011 Immunoprecipitation analyses showed that NAD interacts with the Cystein/Histidine region (CH) 1 and CH3 domains of p300. nadide 41-44 E1A binding protein p300 Homo sapiens 115-119 21925214-7 2011 Moreover, CH1 and CH3 both were required for NAD-dependent transactivation. nadide 45-48 SUN domain containing ossification factor Homo sapiens 10-13 21925214-8 2011 Furthermore, CITED2 was found to inactivate NAD by interfering with NAD binding to CH1, but not to CH3. nadide 44-47 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 13-19 21925214-8 2011 Furthermore, CITED2 was found to inactivate NAD by interfering with NAD binding to CH1, but not to CH3. nadide 44-47 SUN domain containing ossification factor Homo sapiens 83-86 21925214-8 2011 Furthermore, CITED2 was found to inactivate NAD by interfering with NAD binding to CH1, but not to CH3. nadide 68-71 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 13-19 21925214-8 2011 Furthermore, CITED2 was found to inactivate NAD by interfering with NAD binding to CH1, but not to CH3. nadide 68-71 SUN domain containing ossification factor Homo sapiens 83-86 21925214-9 2011 These results indicate that CITED2 inactivates HIF-1alpha by blocking p300 recruitment by both NAD and CAD. nadide 95-98 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 28-34 21925214-9 2011 These results indicate that CITED2 inactivates HIF-1alpha by blocking p300 recruitment by both NAD and CAD. nadide 95-98 hypoxia inducible factor 1 subunit alpha Homo sapiens 47-57 21925214-9 2011 These results indicate that CITED2 inactivates HIF-1alpha by blocking p300 recruitment by both NAD and CAD. nadide 95-98 E1A binding protein p300 Homo sapiens 70-74 21925214-10 2011 We also found that pVHL inhibits NAD activity regardless of NAD degradation by blocking the interaction between p300 and NAD. nadide 33-36 von Hippel-Lindau tumor suppressor Homo sapiens 19-23 21925214-10 2011 We also found that pVHL inhibits NAD activity regardless of NAD degradation by blocking the interaction between p300 and NAD. nadide 33-36 E1A binding protein p300 Homo sapiens 112-116 21925214-11 2011 Summarizing, NAD was activated by binding to p300, and this was blocked by either CITED2 or pVHL. nadide 13-16 E1A binding protein p300 Homo sapiens 45-49 21925214-11 2011 Summarizing, NAD was activated by binding to p300, and this was blocked by either CITED2 or pVHL. nadide 13-16 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 82-88 21925214-11 2011 Summarizing, NAD was activated by binding to p300, and this was blocked by either CITED2 or pVHL. nadide 13-16 von Hippel-Lindau tumor suppressor Homo sapiens 92-96 21925214-12 2011 We propose that pVHL controls NAD during normoxia and that CITED2 controls NAD during hypoxia. nadide 30-33 von Hippel-Lindau tumor suppressor Homo sapiens 16-20 21925214-12 2011 We propose that pVHL controls NAD during normoxia and that CITED2 controls NAD during hypoxia. nadide 75-78 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 59-65 22469636-9 2012 In a univariate logistic regression model including NAD and AT and E, the area under the curve of HSP27 in the receiver-operating-characteristic curve was 0.724, (0.594-0.854, 95% CI; p = 0.0033). nadide 52-55 heat shock protein family B (small) member 1 Homo sapiens 98-103 22469636-10 2012 Interestingly, proinflammatory IL-8 was elevated in those subjects with evidence of AT and E compared to those with AT and NAD. nadide 123-126 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 21925214-2 2011 HIF-1alpha induces the expressions of numerous hypoxia-induced genes through two transactivation domains; N-terminal TAD (NAD) and C-terminal TAD (CAD). nadide 122-125 hypoxia inducible factor 1 subunit alpha Homo sapiens 0-10 21925214-4 2011 However, few researches have focused on the role of CITED2 in the regulation of NAD activity, and thus, we addressed this point. nadide 80-83 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 52-58 21925214-5 2011 CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. nadide 57-60 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 0-6 21925214-5 2011 CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. nadide 57-60 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 112-118 21925214-5 2011 CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. nadide 153-156 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 0-6 21925214-5 2011 CITED2 was found to attenuate the hypoxic activations of NAD-dependent and CAD-dependent genes, suggesting that CITED2 negatively regulates both CAD and NAD. nadide 153-156 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Homo sapiens 112-118 23056490-8 2012 Subsequent comparison of selective epithelial, mesenchymal and cancer stem cell (CSC) markers between AD and NAD populations of CN and CR patients demonstrated an enhanced trend in mRNA expression of E-cadherin, EpCAM, STAT3 and Oct4 in the NAD population of CR patients. nadide 109-112 epithelial cell adhesion molecule Homo sapiens 212-217 23056490-8 2012 Subsequent comparison of selective epithelial, mesenchymal and cancer stem cell (CSC) markers between AD and NAD populations of CN and CR patients demonstrated an enhanced trend in mRNA expression of E-cadherin, EpCAM, STAT3 and Oct4 in the NAD population of CR patients. nadide 109-112 signal transducer and activator of transcription 3 Homo sapiens 219-224 23056490-8 2012 Subsequent comparison of selective epithelial, mesenchymal and cancer stem cell (CSC) markers between AD and NAD populations of CN and CR patients demonstrated an enhanced trend in mRNA expression of E-cadherin, EpCAM, STAT3 and Oct4 in the NAD population of CR patients. nadide 109-112 POU class 5 homeobox 1 Homo sapiens 229-233 23056490-8 2012 Subsequent comparison of selective epithelial, mesenchymal and cancer stem cell (CSC) markers between AD and NAD populations of CN and CR patients demonstrated an enhanced trend in mRNA expression of E-cadherin, EpCAM, STAT3 and Oct4 in the NAD population of CR patients. nadide 241-244 cadherin 1 Homo sapiens 200-210 21549004-1 2011 Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. nadide 79-82 sirtuin 1 Homo sapiens 0-5 21839805-2 2011 In the present study we show that amounts of two of its protein subunits (cytochrome c oxidase subunit I [CO-I] and II [CO-II]) are influenced by both learning-independent and learning-dependent factors. nadide 106-110 COX1 Gallus gallus 74-104 22068497-9 2011 We also observed that MaeB activity was significantly enhanced (7.83-fold) in icd (NAD), which was about 3-fold higher than that in icd (NADP), when switching from glucose to acetate. nadide 107-110 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Escherichia coli str. K-12 substr. MG1655 22-26 22068497-10 2011 The marked increase of MaeB activity was probably induced by the shortage of NADPH in icd (NAD). nadide 77-80 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Escherichia coli str. K-12 substr. MG1655 23-27 21390294-5 2011 NMDA induced a rapid decrease of cytoplasmic NAD (but not mitochondrial NAD) in neurons through poly (ADP-ribose) polymerase-1 (PARP-1) activation. nadide 45-48 poly (ADP-ribose) polymerase family, member 1 Mus musculus 96-126 21390294-5 2011 NMDA induced a rapid decrease of cytoplasmic NAD (but not mitochondrial NAD) in neurons through poly (ADP-ribose) polymerase-1 (PARP-1) activation. nadide 45-48 poly (ADP-ribose) polymerase family, member 1 Mus musculus 128-134 21390294-6 2011 Mitochondrial Sirt3 was increased following PARP-1 mediated NAD depletion, which was reversed by either inhibition of PARP-1 or exogenous NAD. nadide 60-63 sirtuin 3 Mus musculus 14-19 21390294-6 2011 Mitochondrial Sirt3 was increased following PARP-1 mediated NAD depletion, which was reversed by either inhibition of PARP-1 or exogenous NAD. nadide 60-63 poly (ADP-ribose) polymerase family, member 1 Mus musculus 44-50 21390294-6 2011 Mitochondrial Sirt3 was increased following PARP-1 mediated NAD depletion, which was reversed by either inhibition of PARP-1 or exogenous NAD. nadide 60-63 poly (ADP-ribose) polymerase family, member 1 Mus musculus 118-124 21390294-6 2011 Mitochondrial Sirt3 was increased following PARP-1 mediated NAD depletion, which was reversed by either inhibition of PARP-1 or exogenous NAD. nadide 138-141 sirtuin 3 Mus musculus 14-19 21390294-6 2011 Mitochondrial Sirt3 was increased following PARP-1 mediated NAD depletion, which was reversed by either inhibition of PARP-1 or exogenous NAD. nadide 138-141 poly (ADP-ribose) polymerase family, member 1 Mus musculus 44-50 21390294-7 2011 We found that massive reactive oxygen species (ROS) produced under this NAD depleted condition mediated the increase in mitochondrial Sirt3. nadide 72-75 sirtuin 3 Mus musculus 134-139 15128440-1 2004 Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. nadide 130-133 sirtuin 2 Homo sapiens 0-30 20599474-7 2011 The hTau levels were 267.37+-36.64pg/ml, 167.34+-44.27pg/ml and 107.62+-24.27pg/ml in NAD, NC and HC, respectively. nadide 86-89 microtubule associated protein tau Homo sapiens 4-8 18991791-1 2008 Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. nadide 79-82 sirtuin 1 Homo sapiens 0-5 17532487-6 2007 Interestingly, NAD does not constitute the major Ubr2-binding site of Rpn4 even though it serves as the ubiquitylation signal essential for Rpn4 degradation. nadide 15-18 stress-regulated transcription factor RPN4 Saccharomyces cerevisiae S288C 140-144 17532487-2 2007 Our previous work has mapped the ubiquitylation signal of Rpn4, the transcription activator for the Saccharomyces cerevisiae proteasome genes, to an N-terminal acidic domain (NAD) consisting of amino acids 211-229. nadide 175-178 stress-regulated transcription factor RPN4 Saccharomyces cerevisiae S288C 58-62 17532487-3 2007 However, the molecular mechanism by which Ubr2, the cognate E3, recognizes NAD remains unclear. nadide 75-78 putative ubiquitin-protein ligase UBR2 Saccharomyces cerevisiae S288C 42-46 17532487-4 2007 Here we show that phosphorylation of either Ser-214 or Ser-220 enhances the binding of NAD to Ubr2. nadide 87-90 putative ubiquitin-protein ligase UBR2 Saccharomyces cerevisiae S288C 94-98 15632193-1 2005 The SIR2 family of nicotinamide adenosine dinucleotide (NAD)-dependent deacetylases modulates diverse biological functions in different species, including longevity, apoptosis, cell cycle exit, and cellular differentiation. nadide 56-59 sirtuin 1 Homo sapiens 4-8 15632193-4 2005 Herein, SIRT1 physically interacted with and repressed p300 transactivation, requiring the NAD-dependent deacetylase activity of SIRT1. nadide 91-94 sirtuin 1 Homo sapiens 8-13 15632193-4 2005 Herein, SIRT1 physically interacted with and repressed p300 transactivation, requiring the NAD-dependent deacetylase activity of SIRT1. nadide 91-94 E1A binding protein p300 Homo sapiens 55-59 15632193-4 2005 Herein, SIRT1 physically interacted with and repressed p300 transactivation, requiring the NAD-dependent deacetylase activity of SIRT1. nadide 91-94 sirtuin 1 Homo sapiens 129-134 15128440-1 2004 Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. nadide 130-133 sirtuin 2 Homo sapiens 32-36 15128440-4 2004 The Sir2 catalytic domain, which is shared among all sirtuins, consists of two distinct domains that bind NAD and the acetyl-lysine substrate, respectively. nadide 106-109 sirtuin 2 Homo sapiens 4-8 12574164-2 2003 In addition, NAD also serves as a substrate for ADP-ribosylation of a number of nuclear proteins, for silent information regulator 2 (Sir2)-like histone deacetylase that is involved in gene silencing regulation, and for cyclic ADP ribose (cADPR)-dependent Ca(2+) signaling. nadide 13-16 sirtuin 2 Homo sapiens 102-132 12574164-2 2003 In addition, NAD also serves as a substrate for ADP-ribosylation of a number of nuclear proteins, for silent information regulator 2 (Sir2)-like histone deacetylase that is involved in gene silencing regulation, and for cyclic ADP ribose (cADPR)-dependent Ca(2+) signaling. nadide 13-16 sirtuin 2 Homo sapiens 134-138 12574164-7 2003 The characterization of the cytosolic human PNAT-3 provided compelling evidence that the final steps of NAD biosynthesis pathways may exist in mammalian cytoplasm and mitochondria, potentially contributing to their NAD/NADP pool. nadide 104-107 nicotinamide nucleotide adenylyltransferase 3 Homo sapiens 44-50 12574164-7 2003 The characterization of the cytosolic human PNAT-3 provided compelling evidence that the final steps of NAD biosynthesis pathways may exist in mammalian cytoplasm and mitochondria, potentially contributing to their NAD/NADP pool. nadide 215-218 nicotinamide nucleotide adenylyltransferase 3 Homo sapiens 44-50 12575353-6 2002 In NAD, the A beta 1-42 mean value was (231.70 +/- 143.94) fmol.L-1, and it was not significantly different from the mean value for ND. nadide 3-6 AA1 Homo sapiens 12-20 12675907-3 2003 Here we report the novel finding that the enzymatic activity of PARP-1 promotes, in an beta-nicotinamide adenine dinucleotide-dependent fashion, the DNA binding of NF-kappaB in microglia exposed to lipopolysaccharides, interferon-gamma or beta-amyloid 1-40. nadide 87-125 poly (ADP-ribose) polymerase family, member 1 Mus musculus 64-70 12675907-3 2003 Here we report the novel finding that the enzymatic activity of PARP-1 promotes, in an beta-nicotinamide adenine dinucleotide-dependent fashion, the DNA binding of NF-kappaB in microglia exposed to lipopolysaccharides, interferon-gamma or beta-amyloid 1-40. nadide 87-125 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 164-173 1374424-8 1992 In addition, stimulation of PLP139-151-specific T-cell clones by NAd APC did occur when the synthetic peptide instead of intact PLP was used as antigen, indicating a defect in PLP processing by the NAd APC. nadide 65-68 proteolipid protein (myelin) 1 Mus musculus 28-31 10202154-6 1999 In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism. nadide 44-47 CREB binding protein Homo sapiens 134-154 10202154-6 1999 In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta-galactosidase expression in yeast by CBP co-expression, suggesting that NAD and CAD interact with CBP/p300 by a different mechanism. nadide 44-47 CREB binding protein Homo sapiens 156-159 10202154-7 1999 Co-transfection experiments revealed that expression of Ref-1 and thioredoxin further enhanced the luciferase activity expressed by CAD, but not by NAD. nadide 148-151 tissue factor pathway inhibitor 2 Homo sapiens 56-61 9473669-1 1998 Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway. nadide 187-190 quinolinate phosphoribosyltransferase Homo sapiens 10-47 9473669-1 1998 Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway. nadide 187-190 quinolinate phosphoribosyltransferase Homo sapiens 49-56 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. nadide 97-100 fibroblast growth factor 2 Homo sapiens 37-42 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. nadide 97-100 fibroblast growth factor 2 Homo sapiens 162-167 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. nadide 97-100 fibroblast growth factor 2 Homo sapiens 162-167 9173879-4 1997 Excess ADP-ribose had no effect on these reactions, whereas excess NAD inhibited the ADP-ribosylation of FGF-2, consistent with an enzymic rather than a non-enzymic ADP-ribosylation reaction. nadide 67-70 fibroblast growth factor 2 Homo sapiens 105-110 9144920-4 1997 Deletion of amino acids 22 through 39 (in the Xenopus PKG sequence increased the apparent stability of the polypeptide within the embryo and increased its ability to induce a WNT-like, NAD phenotype when expressed in the vegetal hemisphere. nadide 185-188 junction plakoglobin L homeolog Xenopus laevis 54-57 9144920-5 1997 The N-terminal "head" and first 6 "ARM" repeats of PKG, or the C-terminal "tail" and the last 3 "ARM" repeats, could be removed without destroying the remaining polypeptide"s ability to induce a NAD phenotype. nadide 195-198 junction plakoglobin L homeolog Xenopus laevis 51-54 11313963-4 2001 Human BCCIP represents a family of proteins that are evolutionarily conserved, and contain three distinct domains: an N-terminus acidic domain (NAD) of 30-60 amino acids, an internal conserved domain (ICD) of 180-220 amino acids, and a C-terminus variable domain (CVD) of 30-60 amino acids. nadide 144-147 BRCA2 and CDKN1A interacting protein Homo sapiens 6-11 1603265-7 1992 Our results indicate a strong BC200 presence in both the normal brains and NAD affected neocortices, but a 70 per cent reduction in BC200 signal strength in AD afflicted brains. nadide 75-78 brain cytoplasmic RNA 1 Homo sapiens 30-35 1374424-8 1992 In addition, stimulation of PLP139-151-specific T-cell clones by NAd APC did occur when the synthetic peptide instead of intact PLP was used as antigen, indicating a defect in PLP processing by the NAd APC. nadide 65-68 proteolipid protein (myelin) 1 Mus musculus 128-131 1384868-9 1992 Furthermore, the MAb showed no inhibitory reaction with various beta-lactams except aztreonam- and ceftazidime-EACA conjugates in the ELISA inhibition test, suggesting that Az-3 recognize a new antigenic determinant (NAD), which is formed by the conjugation of beta-lactam and carrier protein. nadide 217-220 ornithine decarboxylase antizyme 3 Homo sapiens 173-177