PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3745266-3	1986	Once formed, the TFIIIA-5S DNA complex is stable for greater than 4 h in the absence of free 5S DNA, and its dissociation is identical for somatic and for oocyte 5S DNA.	CHEMBL3739852	24-26	general transcription factor IIIA	Homo sapiens	17-23
3279045-4	1988	The protein moiety of the 5S RNP has been identified as ribosomal protein L5, which is known to be released from ribosomes in a complex with 5S after various treatments of the 60S subunit.	CHEMBL3739852	26-28	ribosomal protein L5	Homo sapiens	56-76
23084291-9	2012	Finally, overexpression of the wild-type PNPT1 cDNA in fibroblasts of subject 1 induced an increase in 5S rRNA import in mitochondria and rescued the mitochondrial-translation deficiency.	CHEMBL3739852	103-105	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	41-46
6887917-5	1983	The binding activity of androgen receptor was unaffected by a treatment with KSCN up to 0.1 M and the androgen-receptor complex sedimented in a 5S form in 0.1-0.3 M KSCN, 0.5 M KCl or 0.5 M KBr.	CHEMBL3739852	144-146	androgen receptor	Homo sapiens	24-41
25855814-8	2015	In addition, gel shift analysis revealed that the Rpf2-Rrs1 complex binds directly to 5S rRNA.	CHEMBL3739852	86-88	rRNA-binding ribosome biosynthesis protein RPF2	Saccharomyces cerevisiae S288C	50-54
25855814-8	2015	In addition, gel shift analysis revealed that the Rpf2-Rrs1 complex binds directly to 5S rRNA.	CHEMBL3739852	86-88	Rrs1p	Saccharomyces cerevisiae S288C	55-59
25720796-2	2015	Maf1 is a RNA polymerase III (PolIII) inhibitor that tailors 5S rRNA and tRNA production in response to various environmental cues.	CHEMBL3739852	61-63	RNA polymerase III-inhibiting protein MAF1	Saccharomyces cerevisiae S288C	0-4
24120868-6	2013	Our data show that the abundance of the 5S RNP, and therefore p53 levels, is determined by factors regulating 5S complex formation and ribosome integration, including the tumor suppressor PICT1.	CHEMBL3739852	40-42	transformation related protein 53, pseudogene	Mus musculus	62-65
24120868-6	2013	Our data show that the abundance of the 5S RNP, and therefore p53 levels, is determined by factors regulating 5S complex formation and ribosome integration, including the tumor suppressor PICT1.	CHEMBL3739852	40-42	NOP53 ribosome biogenesis factor	Mus musculus	188-193
24056189-1	2013	5-Oxo-ETE (5-oxo-6,8,11,14-eicosatetraenoic acid) is formed from the 5-lipoxygenase product 5-HETE (5S-hydroxy-6,8,11,14-eicosatetraenoic acid) by 5-hydroxyeicosanoid dehydrogenase (5-HEDH).	CHEMBL3739852	100-102	arachidonate 5-lipoxygenase	Homo sapiens	69-83
6727349-2	1984	The main difference between RE2 and RE3 was that E3 dissociates from unheated 8S RE3 and heat-transformed 5S RE3 at a much faster rate than E2 from RE2 .	CHEMBL3739852	106-108	epididymal protein 3B	Rattus norvegicus	36-39
28517938-2	2017	The DNA binding affinity is weakened when the cognate ions Ni(II) and Co(II) bind to EcRcnR in a six-coordinate site that features a (N/O)5S ligand donor-atom set in distinct sites: while both metal ions are bound by the N terminus, Cys35, and His64, Co(II) is additionally bound by His3.	CHEMBL3739852	138-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-76
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	CHEMBL3739852	76-78	arachidonate 5-lipoxygenase	Homo sapiens	19-24
21925390-7	2011	These results provide insights into the differential effects on p53 and Mdmx by Mdm2 in vivo and reveal a critical role for noncoding 5S rRNA in modulating the p53-Mdmx axis.	CHEMBL3739852	134-136	tumor protein p53	Homo sapiens	160-163
21925390-7	2011	These results provide insights into the differential effects on p53 and Mdmx by Mdm2 in vivo and reveal a critical role for noncoding 5S rRNA in modulating the p53-Mdmx axis.	CHEMBL3739852	134-136	MDM4 regulator of p53	Homo sapiens	164-168
22238144-0	2011	The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues.	CHEMBL3739852	92-94	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	39-44
21148395-5	2011	Here we demonstrate that rnr1 plants overaccumulate an antisense RNA, AS5, that is complementary to the 5S rRNA, its intergenic spacer, and the downstream trnR gene, which encodes tRNA(Arg), raising the possibility that AS5 destabilizes 5S rRNA or its precursor and/or blocks rRNA maturation.	CHEMBL3739852	104-106	ribonucleotide reductase 1	Arabidopsis thaliana	25-29
21148395-5	2011	Here we demonstrate that rnr1 plants overaccumulate an antisense RNA, AS5, that is complementary to the 5S rRNA, its intergenic spacer, and the downstream trnR gene, which encodes tRNA(Arg), raising the possibility that AS5 destabilizes 5S rRNA or its precursor and/or blocks rRNA maturation.	CHEMBL3739852	237-239	ribonucleotide reductase 1	Arabidopsis thaliana	25-29
21148395-10	2011	We hypothesize that these duplexes are degraded by a dsRNA-specific ribonuclease in vivo, contributing to the 5S rRNA deficiency observed in rnr1.	CHEMBL3739852	110-112	ribonucleotide reductase 1	Arabidopsis thaliana	141-145
21685364-4	2011	In this study, we describe an elegant molecular conveyor composed of a previously identified human 5S rRNA import factor, rhodanese, and mitochondrial ribosomal protein L18, thanks to which 5S rRNA molecules can be specifically withdrawn from the cytosolic pool and redirected to mitochondria, bypassing the classic nucleolar reimport pathway.	CHEMBL3739852	99-101	ribosomal protein L18	Homo sapiens	151-172
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	CHEMBL3739852	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
17432829-4	2007	To elucidate structural properties determining hNeil1"s substrate specificities, we have investigated it in complex with two pairs of representative well-repaired substrates: the R- and S-spiroiminodihydantoin (Sp) stereoisomers, nonplanar further oxidation products of guanine, and the 5R,6S- and 5S,6R-thymine glycol (Tg) stereoisomers, the most prevalent oxidative lesions of thymine.	CHEMBL3739852	298-300	nei like DNA glycosylase 1	Homo sapiens	47-53
11926995-1	2002	Xenopus transcription factor IIIA (TFIIIA) binds 5S rRNA and the 5S rRNA gene, these interactions being mediated by nine zinc fingers.	CHEMBL3739852	49-51	general transcription factor 3A L homeolog	Xenopus laevis	35-41
17291989-1	2007	5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent eosinophil chemoattractant that is synthesized from the 5-lipoxygenase product 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the NADP+-dependent enzyme 5-hydroxyeicosanoid dehydrogenase (5-HEDH), previously reported only in inflammatory cells.	CHEMBL3739852	141-143	arachidonate 5-lipoxygenase	Homo sapiens	118-132
15146977-7	2004	TFIIIA-induced synthesis of 5S rRNA then allows for the formation and nuclear export of the 7S RNP; the 7S RNP is retained in the cytoplasm due to NLS masking via 5S rRNA binding.	CHEMBL3739852	28-30	general transcription factor 3A L homeolog	Xenopus laevis	0-6
15146977-7	2004	TFIIIA-induced synthesis of 5S rRNA then allows for the formation and nuclear export of the 7S RNP; the 7S RNP is retained in the cytoplasm due to NLS masking via 5S rRNA binding.	CHEMBL3739852	163-165	general transcription factor 3A L homeolog	Xenopus laevis	0-6
10624964-6	1999	Muscarinic receptors in brains from GRK5-KO mice resisted oxotremorine-induced desensitization, as assessed by oxotremorine-stimulated [5S]GTPgammaS binding.	CHEMBL3739852	136-138	G protein-coupled receptor kinase 5	Mus musculus	36-40
11306788-9	2001	However, this inhibitory effect of 5S-IgG on endotoxin-mediated TNF-alpha release and the resultant protective effect against endotoxin lethality rapidly diminished when 5S-IgG was administered after the occurrence of TNF-alpha induction.	CHEMBL3739852	35-37	tumor necrosis factor	Rattus norvegicus	64-73
11306788-9	2001	However, this inhibitory effect of 5S-IgG on endotoxin-mediated TNF-alpha release and the resultant protective effect against endotoxin lethality rapidly diminished when 5S-IgG was administered after the occurrence of TNF-alpha induction.	CHEMBL3739852	35-37	tumor necrosis factor	Rattus norvegicus	218-227
11069285-5	2000	Ro60 has been shown to bind mutant 5S rRNA molecules in Xenopus oocytes, suggesting a role for Ro60 in 5S rRNA biogenesis.	CHEMBL3739852	35-37	Ro60, Y RNA binding protein	Homo sapiens	0-4
11069285-5	2000	Ro60 has been shown to bind mutant 5S rRNA molecules in Xenopus oocytes, suggesting a role for Ro60 in 5S rRNA biogenesis.	CHEMBL3739852	103-105	Ro60, Y RNA binding protein	Homo sapiens	0-4
11069285-5	2000	Ro60 has been shown to bind mutant 5S rRNA molecules in Xenopus oocytes, suggesting a role for Ro60 in 5S rRNA biogenesis.	CHEMBL3739852	103-105	Ro60, Y RNA binding protein	Homo sapiens	95-99
10797139-7	2000	The 5S group demonstrated a greater increase in serum cTnT than the 3.5S group (P < 0.01) and the T5S group (P < 0.01) at 0 h PS.	CHEMBL3739852	4-6	troponin T2, cardiac type	Rattus norvegicus	54-58
10797139-9	2000	01) in myocardial cTnT in the 5S group only at 0 h PS (P < 0.01) and 3 h PS (P < 0.05).	CHEMBL3739852	30-32	troponin T2, cardiac type	Rattus norvegicus	18-22
9306250-8	1997	5R-penicilloic acid is the first degradation product of ampicillin and subsequently undergoes epimerization at C-5 to form the 5S isomer via the imine tautomer.	CHEMBL3739852	127-129	complement C5	Homo sapiens	111-114
10546898-3	1999	Although no function has been assigned to the Ro RNP, Ro60 has been shown to bind mutant 5S ribosomal RNA (rRNA) molecules in Xenopus oocytes, suggesting a role for Ro60 in 5S rRNA biogenesis.	CHEMBL3739852	89-91	Ro60, Y RNA binding protein	Homo sapiens	54-58
8610146-3	1996	Transcription factor IIIA (TFIIIA) binds to 5S rRNA transcripts and this interaction has been proposed to play a role in the efficient nuclear export of 5S rRNA in amphibian oocytes.	CHEMBL3739852	44-46	general transcription factor IIIA	Homo sapiens	0-25
8610146-3	1996	Transcription factor IIIA (TFIIIA) binds to 5S rRNA transcripts and this interaction has been proposed to play a role in the efficient nuclear export of 5S rRNA in amphibian oocytes.	CHEMBL3739852	44-46	general transcription factor IIIA	Homo sapiens	27-33
8569695-4	1996	The determination of the apparent Michaelis-Menten kinetic constants revealed that microsomal epoxide hydrolase, regardless of the source, exhibited enantioselectivity, with the 5S,6R-oxide being the preferred substrate.	CHEMBL3739852	178-180	epoxide hydrolase 1	Homo sapiens	83-111
1328270-2	1992	Its (-)-(2S,5S) enantiomer [L-680,573, (S)-I] exhibited higher PAF antagonistic potency than the (+)-(2R,5R) enantiomer [L-680,574, (R)-I] in vitro and in animal models.	CHEMBL3739852	12-14	PCNA clamp associated factor	Rattus norvegicus	63-66
8972774-4	1996	We find that alternative binding modes are available for specific, high-affinity recognition of 5S rRNA by TFIIIA.	CHEMBL3739852	96-98	general transcription factor 3A L homeolog	Xenopus laevis	107-113
8972774-5	1996	These binding modes are distinct kinetically and structurally, and the mode of recognition adopted by wild-type TFIIIA when binding to intact 5S rRNA is dependent on the structural integrity of zinc fingers 5 and 6 in TFIIIA and continuity of the sugar-phosphate backbone in loop A of 5S rRNA.	CHEMBL3739852	142-144	general transcription factor 3A L homeolog	Xenopus laevis	112-118
8972774-5	1996	These binding modes are distinct kinetically and structurally, and the mode of recognition adopted by wild-type TFIIIA when binding to intact 5S rRNA is dependent on the structural integrity of zinc fingers 5 and 6 in TFIIIA and continuity of the sugar-phosphate backbone in loop A of 5S rRNA.	CHEMBL3739852	142-144	general transcription factor 3A L homeolog	Xenopus laevis	218-224
1995392-9	1991	These data suggest that during oogenesis a major pathway for incorporation of 5S RNA into nascent ribosomes involves the migration of 5S RNA from the nucleus to the cytoplasm for storage in an RNP complex with TFIIIA, exchange of that protein association for binding with ribosomal protein L5, and a return to the nucleus for incorporation into ribosomes as they are being assembled in the amplified nucleoli.	CHEMBL3739852	78-80	general transcription factor 3A L homeolog	Xenopus laevis	210-216