PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31530833-7	2019	Histologically, the aortae of DAPT-treated Apoe-/- mice had significant reduction in inflammatory response and elastin fragmentation.	dapt	30-34	apolipoprotein E	Mus musculus	43-47
31530833-7	2019	Histologically, the aortae of DAPT-treated Apoe-/- mice had significant reduction in inflammatory response and elastin fragmentation.	dapt	30-34	elastin	Mus musculus	111-118
31526384-7	2019	Intracerebroventricular DAPT injection and sh-Notch1 lentivirus interference were used to inhibit the Notch1 signaling pathway in vivo and in vitro, respectively.	dapt	24-28	notch receptor 1	Rattus norvegicus	102-108
31163126-7	2019	One group of interest had genes, such as Mybl1, Ascl1, Neurog2, and Olig2, that became upregulated by DAPT treatment before Otx2.	dapt	102-106	myeloblastosis oncogene-like 1	Mus musculus	41-46
31163126-7	2019	One group of interest had genes, such as Mybl1, Ascl1, Neurog2, and Olig2, that became upregulated by DAPT treatment before Otx2.	dapt	102-106	achaete-scute family bHLH transcription factor 1	Mus musculus	48-53
31163126-7	2019	One group of interest had genes, such as Mybl1, Ascl1, Neurog2, and Olig2, that became upregulated by DAPT treatment before Otx2.	dapt	102-106	neurogenin 2	Mus musculus	55-62
31163126-7	2019	One group of interest had genes, such as Mybl1, Ascl1, Neurog2, and Olig2, that became upregulated by DAPT treatment before Otx2.	dapt	102-106	oligodendrocyte transcription factor 2	Mus musculus	68-73
31163126-7	2019	One group of interest had genes, such as Mybl1, Ascl1, Neurog2, and Olig2, that became upregulated by DAPT treatment before Otx2.	dapt	102-106	orthodenticle homeobox 2	Mus musculus	124-128
31345231-14	2019	miR-449a and Notch pathway inhibition using DAPT, significantly increased insulin stimulated PI3K and AKT phosphorylation and these were prevented in the presence of the miR-449a inhibitor.	dapt	44-48	microRNA 449a	Mus musculus	0-8
31209505-5	2019	In addition, the inhibitory effect of N-(N-(3,5-difluorophenacetyl-L-alanyl))-S-phenylglycine t-butyl ester (DAPT) on Th17 differentiation by Notch signaling in vitro was further investigated using T lymphocytes from EAU rats on day 12 post-immunization by flow cytometry.	dapt	109-113	notch receptor 1	Rattus norvegicus	142-147
31209505-10	2019	DAPT can significantly inhibit the activation of Notch signaling, decrease Th17 cell differentiation, and attenuate the level of the Th17 cell lineage, contributing to the balance of the Th17/Treg ratio.	dapt	0-4	notch receptor 1	Rattus norvegicus	49-54
31508369-0	2019	DAPT, a gamma-Secretase Inhibitor, Suppresses Tumorigenesis, and Progression of Growth Hormone-Producing Adenomas by Targeting Notch Signaling.	dapt	0-4	growth hormone 1	Homo sapiens	80-94
31508369-0	2019	DAPT, a gamma-Secretase Inhibitor, Suppresses Tumorigenesis, and Progression of Growth Hormone-Producing Adenomas by Targeting Notch Signaling.	dapt	0-4	notch receptor 2	Homo sapiens	127-132
31508369-8	2019	DAPT, a gamma-secretase inhibitor, inhibited tumor growth and invasion in vivo and in vitro and suppressed the release of growth hormone in primary GHoma cells.	dapt	0-4	growth hormone 1	Homo sapiens	122-136
31508369-9	2019	The involvement of Notch2/DLL3 signaling in GHoma progression warrants additional study of Notch inhibitor, DAPT, as a potential GHoma treatment.	dapt	108-112	notch receptor 2	Homo sapiens	19-25
31508369-9	2019	The involvement of Notch2/DLL3 signaling in GHoma progression warrants additional study of Notch inhibitor, DAPT, as a potential GHoma treatment.	dapt	108-112	delta like canonical Notch ligand 3	Homo sapiens	26-30
31508369-9	2019	The involvement of Notch2/DLL3 signaling in GHoma progression warrants additional study of Notch inhibitor, DAPT, as a potential GHoma treatment.	dapt	108-112	notch receptor 2	Homo sapiens	19-24
31508369-11	2019	We found that the Notch2/Delta-like Notch ligand 3 (DLL3) signaling pathway was active in GHoma tumorigenesis, progression, and invasion.The gamma-secretase inhibitor DAPT is of potential use in GHoma treatment targeting Notch signaling.	dapt	167-171	notch receptor 2	Homo sapiens	18-24
31508369-11	2019	We found that the Notch2/Delta-like Notch ligand 3 (DLL3) signaling pathway was active in GHoma tumorigenesis, progression, and invasion.The gamma-secretase inhibitor DAPT is of potential use in GHoma treatment targeting Notch signaling.	dapt	167-171	delta like canonical Notch ligand 3	Homo sapiens	52-56
31508369-11	2019	We found that the Notch2/Delta-like Notch ligand 3 (DLL3) signaling pathway was active in GHoma tumorigenesis, progression, and invasion.The gamma-secretase inhibitor DAPT is of potential use in GHoma treatment targeting Notch signaling.	dapt	167-171	notch receptor 2	Homo sapiens	18-23
31075347-0	2019	The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism.	dapt	38-42	notch receptor 1	Rattus norvegicus	4-9
31075347-5	2019	However, inhibiting the Notch pathway with (3,5-Difluorophenacetyl)-L-alanyl-S-phenylglycine-2-butyl Ester (Dapt) reduced the overexpression of Notch pathway-related molecules in offspring rats.	dapt	108-112	notch receptor 1	Rattus norvegicus	24-29
31075347-5	2019	However, inhibiting the Notch pathway with (3,5-Difluorophenacetyl)-L-alanyl-S-phenylglycine-2-butyl Ester (Dapt) reduced the overexpression of Notch pathway-related molecules in offspring rats.	dapt	108-112	notch receptor 1	Rattus norvegicus	144-149
31075347-8	2019	We found that the expression of the autophagy-related proteins Beclin 1, LC3B and phospho-p62 in the PFC, HC and CB of VPA model rats increased after Notch signal activation and was inhibited by Dapt compared to those of controls.	dapt	195-199	beclin 1	Rattus norvegicus	63-71
31075347-8	2019	We found that the expression of the autophagy-related proteins Beclin 1, LC3B and phospho-p62 in the PFC, HC and CB of VPA model rats increased after Notch signal activation and was inhibited by Dapt compared to those of controls.	dapt	195-199	notch receptor 1	Rattus norvegicus	150-155
31075347-12	2019	The inhibition of excessive Notch signaling activation by Dapt can alleviate autistic-like behaviors in VPA rats.	dapt	58-62	notch receptor 1	Rattus norvegicus	28-33
31411722-0	2019	Short DAPT after DES: P2Y12 monotherapy is in, aspirin is out!	dapt	6-10	purinergic receptor P2Y12	Homo sapiens	22-27
31158382-9	2019	Moreover, DAPT, a specific inhibitor of Notch signaling pathway, reversed LEC-EMT.	dapt	10-14	notch receptor 1	Homo sapiens	40-45
31345231-14	2019	miR-449a and Notch pathway inhibition using DAPT, significantly increased insulin stimulated PI3K and AKT phosphorylation and these were prevented in the presence of the miR-449a inhibitor.	dapt	44-48	thymoma viral proto-oncogene 1	Mus musculus	102-105
31383289-2	2019	By using the Sulforhodamine B assay, colony-forming units assay, Brdu and Ki67 staining, and flow cytometry assays of apoptosis and cell cycle stage, DAPT was found to inhibit K7M2 proliferation in a dose-dependent manner.	dapt	150-154	antigen identified by monoclonal antibody Ki 67	Mus musculus	74-78
31345231-14	2019	miR-449a and Notch pathway inhibition using DAPT, significantly increased insulin stimulated PI3K and AKT phosphorylation and these were prevented in the presence of the miR-449a inhibitor.	dapt	44-48	microRNA 449a	Mus musculus	170-178
31383289-5	2019	Then, DAPT was found to inhibit Notch1ICD expression in a concentration-dependent manner, and this expression was directly correlated with Phospho-Erk1/2 (p-Erk) by using Western blotting.	dapt	6-10	notch 1	Mus musculus	32-38
31383289-5	2019	Then, DAPT was found to inhibit Notch1ICD expression in a concentration-dependent manner, and this expression was directly correlated with Phospho-Erk1/2 (p-Erk) by using Western blotting.	dapt	6-10	mitogen-activated protein kinase 1	Mus musculus	147-150
31383289-9	2019	We found DAPT inhibits p-Erk in vivo, effectively controls tumor growth, reduces angiogenesis, reduces metastasis to the lungs, and improves overall survival.	dapt	9-13	mitogen-activated protein kinase 1	Mus musculus	25-28
31383289-11	2019	DAPT effectively inhibits osteosarcoma proliferation and metastasis in vivo and in vitro by inhibiting Erk phosphorylation.	dapt	0-4	mitogen-activated protein kinase 1	Mus musculus	103-106
31417656-4	2019	Therefore, in this study, we explored the effects of Notch signaling pathway in cervical cancer by curcumin mediated PDT with/without Notch receptor blocker (DAPT), and hope to elucidate its mechanism.	dapt	158-162	notch receptor 1	Homo sapiens	53-58
31331331-13	2019	Inhibition of cleavage of CD44 with a gamma-secretase inhibitor, DAPT reduced the formation of CD44-ICD; however, accumulation of CD44-external truncation fragments (~ 20 and ~ 25 kDa) was detected.	dapt	65-69	CD44 molecule (Indian blood group)	Homo sapiens	26-30
31331331-13	2019	Inhibition of cleavage of CD44 with a gamma-secretase inhibitor, DAPT reduced the formation of CD44-ICD; however, accumulation of CD44-external truncation fragments (~ 20 and ~ 25 kDa) was detected.	dapt	65-69	CD44 molecule (Indian blood group)	Homo sapiens	95-99
31331331-13	2019	Inhibition of cleavage of CD44 with a gamma-secretase inhibitor, DAPT reduced the formation of CD44-ICD; however, accumulation of CD44-external truncation fragments (~ 20 and ~ 25 kDa) was detected.	dapt	65-69	CD44 molecule (Indian blood group)	Homo sapiens	95-99
31357779-3	2019	Selected CD14(+) monocytes were stimulated by the Notch signaling pathway inhibitor DAPT or transfected with TLR4 siRNA, and the levels of Notch1, Notch2, Hes1 and Hes5 mRNA were detected by real-time quantitative PCR.	dapt	84-88	CD14 molecule	Homo sapiens	9-13
31357779-9	2019	An inhibition of Notch signaling pathway with DAPT had reduced the relative expression level of TLR4 mRNA (2.58 +- 1.36 vs. 4.34 +- 1.88, P < 0.05), protein expression and phosphorylation of NF-B in CD14(+) monocytes of chronic hepatitis C patients.	dapt	46-50	notch receptor 1	Homo sapiens	17-22
31357779-9	2019	An inhibition of Notch signaling pathway with DAPT had reduced the relative expression level of TLR4 mRNA (2.58 +- 1.36 vs. 4.34 +- 1.88, P < 0.05), protein expression and phosphorylation of NF-B in CD14(+) monocytes of chronic hepatitis C patients.	dapt	46-50	toll like receptor 4	Homo sapiens	96-100
31357779-9	2019	An inhibition of Notch signaling pathway with DAPT had reduced the relative expression level of TLR4 mRNA (2.58 +- 1.36 vs. 4.34 +- 1.88, P < 0.05), protein expression and phosphorylation of NF-B in CD14(+) monocytes of chronic hepatitis C patients.	dapt	46-50	CD14 molecule	Homo sapiens	202-206
31417656-7	2019	mRNA and protein expression of gene Notch-1 and its downstream NF-kappaB and VEGF were observed with RT-PCR, immunohistochemical staining and Western-blot with/without inhibition of Notch signaling pathway by DAPT, both in vivo and in vitro experiments.	dapt	209-213	notch 1	Mus musculus	36-43
31417656-7	2019	mRNA and protein expression of gene Notch-1 and its downstream NF-kappaB and VEGF were observed with RT-PCR, immunohistochemical staining and Western-blot with/without inhibition of Notch signaling pathway by DAPT, both in vivo and in vitro experiments.	dapt	209-213	notch receptor 1	Homo sapiens	36-41
31023175-9	2019	Results: RSV promoted neurite outgrowth of cortical neurons, and this effect could be partially prevented by the Notch 1 pathway inhibitor, DAPT.	dapt	140-144	notch receptor 1	Homo sapiens	113-120
31571629-1	2019	Background & objectives: Cytochrome P450, P2Y 12, cyclooxygenase-1 (COX1) and glycoprotein V1 (GPVI) gene polymorphisms are known to affect patient responsiveness towards aspirin and clopidogrel dual antiplatelet therapy (DAPT).	dapt	222-226	prostaglandin-endoperoxide synthase 1	Homo sapiens	50-66
31571629-1	2019	Background & objectives: Cytochrome P450, P2Y 12, cyclooxygenase-1 (COX1) and glycoprotein V1 (GPVI) gene polymorphisms are known to affect patient responsiveness towards aspirin and clopidogrel dual antiplatelet therapy (DAPT).	dapt	222-226	prostaglandin-endoperoxide synthase 1	Homo sapiens	68-72
31571629-1	2019	Background & objectives: Cytochrome P450, P2Y 12, cyclooxygenase-1 (COX1) and glycoprotein V1 (GPVI) gene polymorphisms are known to affect patient responsiveness towards aspirin and clopidogrel dual antiplatelet therapy (DAPT).	dapt	222-226	glycoprotein VI platelet	Homo sapiens	95-99
31571629-11	2019	Interpretation & conclusions: The study showed a significant association of genetic polymorphisms (CYP2C19*2 G>A and GPVI T>C) with DAPT non-responsiveness in MI patients.	dapt	132-136	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	99-106
31571629-11	2019	Interpretation & conclusions: The study showed a significant association of genetic polymorphisms (CYP2C19*2 G>A and GPVI T>C) with DAPT non-responsiveness in MI patients.	dapt	132-136	glycoprotein VI platelet	Homo sapiens	117-121
31073804-8	2019	hDPSCs were cultured in neural induction medium and N-[N-(3,5-difluorophenacetyl-L-alanyl)]-Sphenylglycine t-butyl ester (DAPT) was applied to impede Notch signaling during transformation into spheres or on the formed neurospheres.	dapt	122-126	notch receptor 1	Homo sapiens	150-155
31073804-9	2019	Our results showed that the size and number of neurospheres decreased and the expression profile of nestin, sox1 and pax6 genes reduced provided DAPT.	dapt	145-149	nestin	Homo sapiens	100-106
31073804-9	2019	Our results showed that the size and number of neurospheres decreased and the expression profile of nestin, sox1 and pax6 genes reduced provided DAPT.	dapt	145-149	SRY-box transcription factor 1	Homo sapiens	108-112
31073804-9	2019	Our results showed that the size and number of neurospheres decreased and the expression profile of nestin, sox1 and pax6 genes reduced provided DAPT.	dapt	145-149	paired box 6	Homo sapiens	117-121
31073804-10	2019	Treatment of the formed neurospheres with DAPT resulted in the cleaved Notch1 reduction, G0/G1 arrest and a decline in L-lactate production.	dapt	42-46	notch receptor 1	Homo sapiens	71-77
31073804-11	2019	DAPT significantly reduced hes1 and hey1 genes, while ascl1 and neurogenin2 expressions augmented.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	27-31
31073804-11	2019	DAPT significantly reduced hes1 and hey1 genes, while ascl1 and neurogenin2 expressions augmented.	dapt	0-4	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	36-40
31073804-12	2019	The number of MAP2 positive cells improved in the DAPT-treated group.	dapt	50-54	microtubule associated protein 2	Homo sapiens	14-18
31028097-8	2019	Therapeutic inhibition of Notch1 activity with gamma secretase inhibitors RO4929097 or DAPT in prostate cancer cells further results in decreased proliferative abilities.	dapt	87-91	notch receptor 1	Homo sapiens	26-32
31023175-11	2019	In addition, we observed that the levels of both Notch 1 and Hes 1 in cortical neurons were increased after RSV, but sharply decreased after DAPT treatment.	dapt	141-145	notch receptor 1	Homo sapiens	49-56
31023175-11	2019	In addition, we observed that the levels of both Notch 1 and Hes 1 in cortical neurons were increased after RSV, but sharply decreased after DAPT treatment.	dapt	141-145	hes family bHLH transcription factor 1	Homo sapiens	61-66
31023175-12	2019	Moreover, RSV increased brain-derived neurotrophic factor (BDNF) levels in cortical neurons, but in the culture medium, and the effect could be partially suppressed by DAPT treatment.	dapt	168-172	brain derived neurotrophic factor	Homo sapiens	24-57
31023175-12	2019	Moreover, RSV increased brain-derived neurotrophic factor (BDNF) levels in cortical neurons, but in the culture medium, and the effect could be partially suppressed by DAPT treatment.	dapt	168-172	brain derived neurotrophic factor	Homo sapiens	59-63
31242837-1	2019	BACKGROUND: Dual antiplatelet therapy (DAPT) with aspirin and one of inhibitors of P2Y12 receptors (clopidogrel, ticagrelor, prasugrel) is an international standard of receptors (clopidogrel, ticagrelor, prasugrel) is an international standard of is an international standard of treatment strategy in patients with acute coronary syndrome (ACS).	dapt	39-43	purinergic receptor P2Y12	Homo sapiens	83-88
31237645-1	2019	Importance: Data on P2Y12 inhibitor monotherapy after short-duration dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention are limited.	dapt	96-100	purinergic receptor P2Y12	Homo sapiens	20-25
31237645-2	2019	Objective: To determine whether P2Y12 inhibitor monotherapy after 3 months of DAPT is noninferior to 12 months of DAPT in patients undergoing PCI.	dapt	78-82	purinergic receptor P2Y12	Homo sapiens	32-37
31258858-1	2019	Background: Long-term oral anticoagulants (OAC) increases bleeding risk after the percutaneous coronary intervention (PCI) with dual antiplatelet therapy (DAPT) with Aspirin and P2Y12 inhibitors.	dapt	155-159	purinergic receptor P2Y12	Homo sapiens	178-183
31237645-14	2019	Conclusions and Relevance: Among patients undergoing percutaneous coronary intervention, P2Y12 inhibitor monotherapy after 3 months of DAPT compared with prolonged DAPT resulted in noninferior rates of major adverse cardiac and cerebrovascular events.	dapt	135-139	purinergic receptor P2Y12	Homo sapiens	89-94
31281386-7	2019	The effects of dexamethasone and DAPT (inhibitor of Notch signaling) on osteogenesis of BMSCs were detected by BCIP/NBT, Alizarin red S staining, and real-time PCR.	dapt	33-37	notch receptor 2	Rattus norvegicus	52-57
31281386-12	2019	Dexamethasone and DAPT could downregulate the high expression of Notch4, Hes1, Hey2 and upregulate the low expression of Runx2 in BMSCs which cocultured with LPS treated B lymphocytes, the inhibited ALP and Alizarin red staining in BMSCs which cocultured with LPS treated B lymphocytes also partly restored.	dapt	18-22	notch receptor 4	Rattus norvegicus	65-71
31281386-12	2019	Dexamethasone and DAPT could downregulate the high expression of Notch4, Hes1, Hey2 and upregulate the low expression of Runx2 in BMSCs which cocultured with LPS treated B lymphocytes, the inhibited ALP and Alizarin red staining in BMSCs which cocultured with LPS treated B lymphocytes also partly restored.	dapt	18-22	hes family bHLH transcription factor 1	Rattus norvegicus	73-77
31281386-12	2019	Dexamethasone and DAPT could downregulate the high expression of Notch4, Hes1, Hey2 and upregulate the low expression of Runx2 in BMSCs which cocultured with LPS treated B lymphocytes, the inhibited ALP and Alizarin red staining in BMSCs which cocultured with LPS treated B lymphocytes also partly restored.	dapt	18-22	hes-related family bHLH transcription factor with YRPW motif 2	Rattus norvegicus	79-83
31281386-12	2019	Dexamethasone and DAPT could downregulate the high expression of Notch4, Hes1, Hey2 and upregulate the low expression of Runx2 in BMSCs which cocultured with LPS treated B lymphocytes, the inhibited ALP and Alizarin red staining in BMSCs which cocultured with LPS treated B lymphocytes also partly restored.	dapt	18-22	RUNX family transcription factor 2	Rattus norvegicus	121-126
31281386-12	2019	Dexamethasone and DAPT could downregulate the high expression of Notch4, Hes1, Hey2 and upregulate the low expression of Runx2 in BMSCs which cocultured with LPS treated B lymphocytes, the inhibited ALP and Alizarin red staining in BMSCs which cocultured with LPS treated B lymphocytes also partly restored.	dapt	18-22	PDZ and LIM domain 3	Rattus norvegicus	199-202
31145652-8	2019	As Notch activity was blocked by the DAPT, the related proteins were downregulated, and the initiating cell proliferation of curcumin was abolished.	dapt	37-41	notch 1	Mus musculus	3-8
30393992-13	2019	Dual-antiplatelet therapy (DAPT) or use of oral anticoagulation was associated with a reduced incidence of ACS (17% vs. 34%, P = 0.03 and 29% vs. 42%, P = 0.02, respectively).	dapt	27-31	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	107-110
30393992-15	2019	DAPT or oral anticoagulation reduces the risk of future ACS.	dapt	0-4	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	56-59
30928640-4	2019	Further analysis evidenced that DAPT attenuated the activation of Activin A on Shh signaling.	dapt	32-36	sonic hedgehog signaling molecule	Homo sapiens	79-82
31249601-6	2019	Then, DAPT and soluble Jagged1 (SJAG) were applied to inhibit or enhance the expression of the Notch1 pathway, respectively, resulting in the upregulation or downregulation of collagen II, aggrecan, and Sox9 in MSCs.	dapt	6-10	notch receptor 1	Rattus norvegicus	95-101
30925201-1	2019	DAPT is a potent gamma-secretase (GS) inhibitor that blocks the production of short amyloid-beta (Abeta) peptides.	dapt	0-4	amyloid beta precursor protein	Homo sapiens	84-96
30925201-1	2019	DAPT is a potent gamma-secretase (GS) inhibitor that blocks the production of short amyloid-beta (Abeta) peptides.	dapt	0-4	amyloid beta precursor protein	Homo sapiens	98-103
30925201-5	2019	Our simulations showed a high preference of DAPT for the intramembrane region of the protein and that its entry site is located between TM2 and TM3 of PS1.	dapt	44-48	taste 2 receptor member 62 pseudogene	Homo sapiens	151-154
30925201-6	2019	DAPT interaction with the active site led to a decreased flexibility of key PS1 regions related to the recognition and internalization of GS substrates.	dapt	0-4	taste 2 receptor member 62 pseudogene	Homo sapiens	76-79
31298400-11	2019	Using DAPT to block Notch1 signaling could reverse the protective effects of Berberine and Hesperidin.	dapt	6-10	notch receptor 1	Homo sapiens	20-26
30954415-10	2019	We further demonstrated that pharmacological inhibition of Notch3 activity by using a gamma-secretase inhibitor DAPT, which blocked the cleavage of Notch proteins to ICD peptides, could effectively inhibit PASMC proliferation.	dapt	112-116	notch receptor 3	Rattus norvegicus	59-65
30954415-10	2019	We further demonstrated that pharmacological inhibition of Notch3 activity by using a gamma-secretase inhibitor DAPT, which blocked the cleavage of Notch proteins to ICD peptides, could effectively inhibit PASMC proliferation.	dapt	112-116	notch receptor 3	Rattus norvegicus	59-64
30954415-12	2019	We found that administration of Notch signaling inhibitor DAPT could successfully reduce mean pulmonary arterial pressure in EUGR rats.	dapt	58-62	notch receptor 3	Rattus norvegicus	32-37
31198410-2	2019	When dual antiplatelet therapy (DAPT) is required, a P2Y12-antagonist is usually recommended in addition to standard aspirin therapy.	dapt	32-36	purinergic receptor P2Y12	Homo sapiens	53-58
30988066-6	2019	Tregs/Th17 percentages, transcriptional factors, and cytokines production were investigated in response to the stimulation of Notch signaling inhibitor DAPT.	dapt	152-156	notch receptor 1	Homo sapiens	126-131
30988066-9	2019	DAPT treatment did not affect frequency of either circulating Tregs or Th17 cells, however, reduced FoxP3/RORgammat mRNA expression and interleukin (IL)-35/IL-17 production in purified CD4+ T cells from GC patients.	dapt	0-4	forkhead box P3	Homo sapiens	100-105
30988066-9	2019	DAPT treatment did not affect frequency of either circulating Tregs or Th17 cells, however, reduced FoxP3/RORgammat mRNA expression and interleukin (IL)-35/IL-17 production in purified CD4+ T cells from GC patients.	dapt	0-4	interleukin 17A	Homo sapiens	156-161
30988066-9	2019	DAPT treatment did not affect frequency of either circulating Tregs or Th17 cells, however, reduced FoxP3/RORgammat mRNA expression and interleukin (IL)-35/IL-17 production in purified CD4+ T cells from GC patients.	dapt	0-4	CD4 molecule	Homo sapiens	185-188
30710735-11	2019	Although minimal impact on aspirin esterase activity for all co-administered herbs, significant inhibition on rCyp2c11 and carboxylesterase activities were observed for DAPT with Danshen, Gegen and Danggui co-treatment.	dapt	169-173	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	110-118
30710735-15	2019	CONCLUSION: Among the four studied TCMs, it was demonstrated that co-administration of Gegen and Danggui could lead to altered pharmacokinetics of DAPT with significant inhibition on rCyp2c11 and carboxylesterase activities.	dapt	147-151	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	183-191
31093499-6	2019	DAPT, a Notch signaling inhibitor, exerted similar effects in SCLC.	dapt	0-4	notch receptor 1	Homo sapiens	8-13
30895661-6	2019	Pathway inhibitor DAPT was employed to confirm the regulatory effect of KK-LC-1 on the downstream Notch signalling.	dapt	18-22	cancer/testis antigen 83	Homo sapiens	72-79
30895661-6	2019	Pathway inhibitor DAPT was employed to confirm the regulatory effect of KK-LC-1 on the downstream Notch signalling.	dapt	18-22	notch receptor 1	Homo sapiens	98-103
31105691-4	2019	Here, we demonstrate that DAPT, inhibitor of gamma-secretase that participates in activation of Notch receptors, inhibited the migration and invasion of TNBC cells that were grown in "Contact" co-cultures with MSCs or with patient-derived cancer-associated fibroblasts (CAFs), in the presence of TNFalpha.	dapt	26-30	tumor necrosis factor	Homo sapiens	296-304
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	55-60
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	tumor necrosis factor	Homo sapiens	82-90
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	interleukin 1 beta	Homo sapiens	96-104
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	lysine acetyltransferase 2B	Homo sapiens	125-128
31105691-5	2019	DAPT also inhibited the contact-dependent induction of CXCL8, but not of CCL5, in TNFalpha- and IL-1beta-stimulated TNBC:MSC/CAF co-cultures; some level of heterogeneity between the responses of different TNBC cell lines was noted, with MDA-MB-231:MSC/CAF co-cultures being the most sensitive to DAPT.	dapt	0-4	lysine acetyltransferase 2B	Homo sapiens	252-255
31218097-3	2019	Clinical efforts to translate the DAPT, which blocks Notch signaling, have been unsuccessful due to a combination of serious gastrointestinal side effects and a lack of complete blocking efficacy.	dapt	34-38	notch receptor 2	Homo sapiens	53-58
30259982-7	2019	The inhibitor of Notch-1, DAPT, reduced all the effects of Jagged-1 on nasal epithelial cells.	dapt	26-30	notch receptor 1	Homo sapiens	17-24
31057403-4	2019	Here we demonstrated that DAPT, a gamma secretase inhibitor, inhibited protrusion formation and cell motility, and then reduced the migration of triple-negative breast cancer cells, through increasing the activity of Cdc42 by non-canonical Notch pathway.	dapt	26-30	cell division cycle 42	Homo sapiens	217-222
31057403-5	2019	Phosphorylation of AKT on S473 was surprisingly increased when Notch signaling was inhibited by DAPT.	dapt	96-100	AKT serine/threonine kinase 1	Homo sapiens	19-22
31057403-6	2019	Inhibition of PI3K and AKT by LY294002 and MK2206, respectively, or knockdown of AKT expression by siRNA blocked DAPT-induced activation of Cdc42.	dapt	113-117	AKT serine/threonine kinase 1	Homo sapiens	81-84
31057403-6	2019	Inhibition of PI3K and AKT by LY294002 and MK2206, respectively, or knockdown of AKT expression by siRNA blocked DAPT-induced activation of Cdc42.	dapt	113-117	cell division cycle 42	Homo sapiens	140-145
31057403-8	2019	Taken together, these results indicated that DAPT inhibited Notch signaling and consequently activated PI3K/AKT/Cdc42 signaling by non-canonical pathway, facilitated the formation of filopodia and inhibited the assembly of lamellipodia, and finally resulted in the decrease of migration activity of breast cancer cells.	dapt	45-49	AKT serine/threonine kinase 1	Homo sapiens	108-111
31057403-8	2019	Taken together, these results indicated that DAPT inhibited Notch signaling and consequently activated PI3K/AKT/Cdc42 signaling by non-canonical pathway, facilitated the formation of filopodia and inhibited the assembly of lamellipodia, and finally resulted in the decrease of migration activity of breast cancer cells.	dapt	45-49	cell division cycle 42	Homo sapiens	112-117
30259982-7	2019	The inhibitor of Notch-1, DAPT, reduced all the effects of Jagged-1 on nasal epithelial cells.	dapt	26-30	jagged canonical Notch ligand 1	Homo sapiens	59-67
30998155-5	2019	Then, the expression of Notch1 in cells was inhibited by notch1 inhibitor DAPT and RNA interference, the above-motioned experiments should be repeated.	dapt	74-78	notch receptor 1	Homo sapiens	24-30
31039217-0	2019	PURL: Should you switch the DAPT agent one month after ACS?	dapt	28-32	phosphoribosylformylglycinamidine synthase	Homo sapiens	0-4
31039217-0	2019	PURL: Should you switch the DAPT agent one month after ACS?	dapt	28-32	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	55-58
30867133-5	2019	Treatment of micromass cultures with DAPT, a gamma-secretase inhibitor, damped Hes1 oscillations, elevated Gal-1A and -8 mRNA levels, and led to irregularly-sized proto-condensations that subsequently fused.	dapt	37-41	hes family bHLH transcription factor 1	Homo sapiens	79-83
30867133-5	2019	Treatment of micromass cultures with DAPT, a gamma-secretase inhibitor, damped Hes1 oscillations, elevated Gal-1A and -8 mRNA levels, and led to irregularly-sized proto-condensations that subsequently fused.	dapt	37-41	galectin 8	Homo sapiens	107-120
30867133-6	2019	In developing limb buds, DAPT led to spatially non-uniform Hes1 expression and fused, truncated and misshapen digits.	dapt	25-29	hes family bHLH transcription factor 1	Homo sapiens	59-63
30998155-5	2019	Then, the expression of Notch1 in cells was inhibited by notch1 inhibitor DAPT and RNA interference, the above-motioned experiments should be repeated.	dapt	74-78	notch receptor 1	Homo sapiens	57-63
30839370-6	2019	THERAPEUTIC ADVANCES: DAPT (aspirin and only clopidogrel among all P2Y12 inhibitors) might be maintained or initiated for CHD in patients with minor acute stroke and high-risk transient ischemic attack patient with IS attributable to an important intracranial stenosis, as long as this drug combination proved to be safe for them in the prevention of stroke recurrence.	dapt	22-26	purinergic receptor P2Y12	Homo sapiens	67-72
30930891-5	2019	We found that Notch1 signaling blockade with N-[N-(3, 5-difluorophenacetyl)-1-alany1-S-phenyglycine t-butyl ester (DAPT) shifted retinal microglia phenotype from pro-inflammatory M1 phenotype (COX2+ and iNOS+) to anti-inflammatory M2 phenotype (Arg-1+) and reduced the release of pro-inflammatory cytokines both in vivo and in vitro.	dapt	115-119	notch receptor 1	Rattus norvegicus	14-20
30930891-5	2019	We found that Notch1 signaling blockade with N-[N-(3, 5-difluorophenacetyl)-1-alany1-S-phenyglycine t-butyl ester (DAPT) shifted retinal microglia phenotype from pro-inflammatory M1 phenotype (COX2+ and iNOS+) to anti-inflammatory M2 phenotype (Arg-1+) and reduced the release of pro-inflammatory cytokines both in vivo and in vitro.	dapt	115-119	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	193-197
30930891-5	2019	We found that Notch1 signaling blockade with N-[N-(3, 5-difluorophenacetyl)-1-alany1-S-phenyglycine t-butyl ester (DAPT) shifted retinal microglia phenotype from pro-inflammatory M1 phenotype (COX2+ and iNOS+) to anti-inflammatory M2 phenotype (Arg-1+) and reduced the release of pro-inflammatory cytokines both in vivo and in vitro.	dapt	115-119	nitric oxide synthase 2	Rattus norvegicus	203-207
30930891-5	2019	We found that Notch1 signaling blockade with N-[N-(3, 5-difluorophenacetyl)-1-alany1-S-phenyglycine t-butyl ester (DAPT) shifted retinal microglia phenotype from pro-inflammatory M1 phenotype (COX2+ and iNOS+) to anti-inflammatory M2 phenotype (Arg-1+) and reduced the release of pro-inflammatory cytokines both in vivo and in vitro.	dapt	115-119	arginase 1	Rattus norvegicus	245-250
30778288-10	2019	These effects are blocked by the administration of the gamma-secretase inhibitor DAPT, a specific blocker of the Notch signaling pathway.	dapt	81-85	notch 1	Mus musculus	113-118
30590978-8	2019	Blocking Notch receptor activation with the gamma-secretase inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) diminished these effects.	dapt	70-74	notch receptor 1	Homo sapiens	9-14
30590978-8	2019	Blocking Notch receptor activation with the gamma-secretase inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) diminished these effects.	dapt	76-145	notch receptor 1	Homo sapiens	9-14
30690027-9	2019	In this study, we observed an enhanced DNA damage and cellular apoptosis via the ATM/CHK2/P53 pathway(s) in HeLa and SiHa cells treated with cisplatin combined with DAPT of Notch1 inhibitor.	dapt	165-169	ATM serine/threonine kinase	Homo sapiens	81-84
30690027-9	2019	In this study, we observed an enhanced DNA damage and cellular apoptosis via the ATM/CHK2/P53 pathway(s) in HeLa and SiHa cells treated with cisplatin combined with DAPT of Notch1 inhibitor.	dapt	165-169	checkpoint kinase 2	Homo sapiens	85-89
30690027-9	2019	In this study, we observed an enhanced DNA damage and cellular apoptosis via the ATM/CHK2/P53 pathway(s) in HeLa and SiHa cells treated with cisplatin combined with DAPT of Notch1 inhibitor.	dapt	165-169	tumor protein p53	Homo sapiens	90-93
30690027-9	2019	In this study, we observed an enhanced DNA damage and cellular apoptosis via the ATM/CHK2/P53 pathway(s) in HeLa and SiHa cells treated with cisplatin combined with DAPT of Notch1 inhibitor.	dapt	165-169	notch receptor 1	Homo sapiens	173-179
30539813-0	2019	Neuroprotective effect of Notch pathway inhibitor DAPT against focal cerebral ischemia/reperfusion 3 hours before model establishment.	dapt	50-54	notch 1	Mus musculus	26-31
30539813-1	2019	As an inhibitor of the Notch signaling pathway, N-[N-(3,5-difluorohenacetyl)-l-alanyl]-S-phenylglycine tert-butyl ester (DAPT) may protect brain tissue from serious ischemic injury.	dapt	121-125	notch 1	Mus musculus	23-28
30539813-8	2019	DAPT decreased the number of glial fibrillary acidic protein- and Notch1-positive cells in the right prefrontal cortex, while also reducing the number of apoptotic cells and decreasing interleukin-6 and tumor necrosis factor-alpha contents, and simultaneously downregulating Hes1 and Hes5 protein expression.	dapt	0-4	notch 1	Mus musculus	66-72
30539813-8	2019	DAPT decreased the number of glial fibrillary acidic protein- and Notch1-positive cells in the right prefrontal cortex, while also reducing the number of apoptotic cells and decreasing interleukin-6 and tumor necrosis factor-alpha contents, and simultaneously downregulating Hes1 and Hes5 protein expression.	dapt	0-4	interleukin 6	Mus musculus	185-230
30539813-8	2019	DAPT decreased the number of glial fibrillary acidic protein- and Notch1-positive cells in the right prefrontal cortex, while also reducing the number of apoptotic cells and decreasing interleukin-6 and tumor necrosis factor-alpha contents, and simultaneously downregulating Hes1 and Hes5 protein expression.	dapt	0-4	hes family bHLH transcription factor 1	Mus musculus	275-279
30539813-8	2019	DAPT decreased the number of glial fibrillary acidic protein- and Notch1-positive cells in the right prefrontal cortex, while also reducing the number of apoptotic cells and decreasing interleukin-6 and tumor necrosis factor-alpha contents, and simultaneously downregulating Hes1 and Hes5 protein expression.	dapt	0-4	hes family bHLH transcription factor 5	Mus musculus	284-288
30529759-7	2019	While JAG1-induced Hes1 and Hey1 expression levels were predictably decreased after DAPT (NOTCH inhibitor) treatment, JAG1-induced Runx2 and Ocn levels were surprisingly constant in the presence of DAPT, indicating that JAG1 effects in the CNC cells are independent of the canonical NOTCH pathway.	dapt	198-202	jagged 1	Mus musculus	118-122
30529759-7	2019	While JAG1-induced Hes1 and Hey1 expression levels were predictably decreased after DAPT (NOTCH inhibitor) treatment, JAG1-induced Runx2 and Ocn levels were surprisingly constant in the presence of DAPT, indicating that JAG1 effects in the CNC cells are independent of the canonical NOTCH pathway.	dapt	198-202	jagged 1	Mus musculus	118-122
30529759-9	2019	Pharmacologic inhibition of JAK2 phosphorylation, with and without DAPT treatment, upon JAG1 induction reduced ALP production and, Runx2 and Ocn gene expression.	dapt	67-71	jagged 1	Mus musculus	88-92
30529759-9	2019	Pharmacologic inhibition of JAK2 phosphorylation, with and without DAPT treatment, upon JAG1 induction reduced ALP production and, Runx2 and Ocn gene expression.	dapt	67-71	alkaline phosphatase, placental	Homo sapiens	111-114
30614864-1	2019	OBJECTIVE: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of treatment in patients with acute coronary syndromes (ACS) and in those undergoing percutaneous coronary intervention (PCI).	dapt	38-42	purinergic receptor P2Y12	Homo sapiens	63-68
30336218-9	2019	Finally, consistently with the results from Notch inhibitor DAPT treatment, rapamycin suppressed the migration of HUVECs in vitro.	dapt	60-64	notch receptor 1	Homo sapiens	44-49
30652694-0	2019	Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway.	dapt	27-31	delta like canonical Notch ligand 4	Rattus norvegicus	121-140
31105977-16	2019	Conclusion: The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.	dapt	64-68	integrin subunit alpha 2b	Homo sapiens	27-33
31359737-9	2019	We next interrogated the effects of the Notch inhibitor DAPT and confirmed an inhibition of beta-GP up-regulated Notch3 protein by C2, DAPT and crizotinib compared to controls.	dapt	135-139	notch receptor 3	Homo sapiens	113-119
31359737-10	2019	Hes-1 protein upregulation by beta-GP, was also significantly downregulated by C2 and DAPT.	dapt	86-90	hes family bHLH transcription factor 1	Homo sapiens	0-5
30652694-0	2019	Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway.	dapt	27-31	notch receptor 1	Rattus norvegicus	141-156
30652694-0	2019	Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway.	dapt	27-31	delta like canonical Notch ligand 4	Rattus norvegicus	158-162
30652694-0	2019	Gamma-Secretase Inhibitor, DAPT, Prevents the Development of Retinopathy of Prematurity in a Rat Model by Regulating the Delta-Like Ligand 4/Notch Homolog-1 (DLL4/Notch-1) Pathway.	dapt	27-31	notch receptor 1	Rattus norvegicus	163-170
30652694-8	2019	RESULTS The rat model of ROP showed increased serum levels of VEGF, VEGFR-1, and VEGFR-2 compared with the control group, which were decreased in the DAPT group.	dapt	150-154	vascular endothelial growth factor A	Rattus norvegicus	62-66
30689068-2	2019	Treating ACS patients with dual antiplatelet therapy (DAPT) for a year by combining aspirin and a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) has resulted in better outcomes and is currently the standard of therapy.	dapt	54-58	purinergic receptor P2Y12	Homo sapiens	98-103
30652694-8	2019	RESULTS The rat model of ROP showed increased serum levels of VEGF, VEGFR-1, and VEGFR-2 compared with the control group, which were decreased in the DAPT group.	dapt	150-154	Fms related receptor tyrosine kinase 1	Rattus norvegicus	68-75
30652694-8	2019	RESULTS The rat model of ROP showed increased serum levels of VEGF, VEGFR-1, and VEGFR-2 compared with the control group, which were decreased in the DAPT group.	dapt	150-154	kinase insert domain receptor	Rattus norvegicus	81-88
30652694-9	2019	Histology of the retinal tissue in the model group showed degeneration of the retinal ganglion cells, and immunohistochemistry showed increased expression of Notch-1 and DLL4 compared with the control group and DAPT group.	dapt	211-215	notch receptor 1	Rattus norvegicus	158-165
30652694-11	2019	CONCLUSIONS In a rat model, treatment with DAPT reduced the retinal changes associated with ROP with a mechanism that involved VEGF and its receptors through the DLL4/Notch-1 pathway.	dapt	43-47	vascular endothelial growth factor A	Rattus norvegicus	127-131
30652694-11	2019	CONCLUSIONS In a rat model, treatment with DAPT reduced the retinal changes associated with ROP with a mechanism that involved VEGF and its receptors through the DLL4/Notch-1 pathway.	dapt	43-47	delta like canonical Notch ligand 4	Rattus norvegicus	162-166
30652694-11	2019	CONCLUSIONS In a rat model, treatment with DAPT reduced the retinal changes associated with ROP with a mechanism that involved VEGF and its receptors through the DLL4/Notch-1 pathway.	dapt	43-47	notch receptor 1	Rattus norvegicus	167-174
29521570-1	2019	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is a mainstay of the prevention of stent thrombosis following percutaneous coronary intervention (PCI).	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
30407728-0	2019	gamma-secretase inhibitor DAPT mitigates cisplatin-induced acute kidney injury by suppressing Notch1 signaling.	dapt	26-30	notch receptor 1	Homo sapiens	94-100
30407728-10	2019	siRNA-mediated Dll1 knockdown and DAPT attenuated cisplatin-induced Notch1 cleavage and cytotoxicity in HK-2 cells.	dapt	34-38	notch receptor 1	Homo sapiens	68-74
30121620-8	2019	Cnot1 mRNA levels were also increased in the pituitary xenografts by DAPT treatment.	dapt	69-73	CCR4-NOT transcription complex, subunit 1	Rattus norvegicus	0-5
29964327-7	2019	We also found that the combination of CDDP and DAPT exhibit additive suppression on phosphorylated AKT and ERK, contributing to the anti-cancer effects.	dapt	47-51	AKT serine/threonine kinase 1	Homo sapiens	99-102
29964327-7	2019	We also found that the combination of CDDP and DAPT exhibit additive suppression on phosphorylated AKT and ERK, contributing to the anti-cancer effects.	dapt	47-51	mitogen-activated protein kinase 1	Homo sapiens	107-110
30430898-6	2019	In addition, we showed that TGF-beta1 significantly induced proliferation of PASMC, while pre-inhibition of Smad2/3 phosphorylation with SB431542 or silencing SphK1 using small interfering RNA in advance, or pre-blocking Notch3 pathway with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), attenuated TGF-beta1-induced PASMC proliferation.	dapt	241-310	transforming growth factor beta 1	Homo sapiens	28-37
30430898-6	2019	In addition, we showed that TGF-beta1 significantly induced proliferation of PASMC, while pre-inhibition of Smad2/3 phosphorylation with SB431542 or silencing SphK1 using small interfering RNA in advance, or pre-blocking Notch3 pathway with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), attenuated TGF-beta1-induced PASMC proliferation.	dapt	312-316	transforming growth factor beta 1	Homo sapiens	28-37
30573741-5	2018	We further show that two gamma secretase inhibitors (GSIs), DAPT (GSI-IX) and RO4929097, cause dose-dependent inhibition of Notch target gene expression (Hey1) and rate of migration of monolayer cultures of lymphatic endothelial cells (hLECs) and blood endothelial cells (HUVEC).	dapt	60-64	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	154-158
30583672-6	2018	Additionally, DAPT treatment of cells significantly decreased Hes-1 mRNA levels(p < 0.05) as well as activity of MMP-2 and -9 (p < 0.05).	dapt	14-18	hes family bHLH transcription factor 1	Homo sapiens	62-67
30583672-6	2018	Additionally, DAPT treatment of cells significantly decreased Hes-1 mRNA levels(p < 0.05) as well as activity of MMP-2 and -9 (p < 0.05).	dapt	14-18	matrix metallopeptidase 2	Homo sapiens	116-128
30573741-5	2018	We further show that two gamma secretase inhibitors (GSIs), DAPT (GSI-IX) and RO4929097, cause dose-dependent inhibition of Notch target gene expression (Hey1) and rate of migration of monolayer cultures of lymphatic endothelial cells (hLECs) and blood endothelial cells (HUVEC).	dapt	66-72	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	154-158
30218844-1	2018	BACKGROUND: While extended dual antiplatelet therapy (DAPT) with aspirin and a platelet (P2Y12) inhibitor after percutaneous coronary intervention (PCI) reduces the risk of stent thrombosis (ST) and myocardial infarction (MI), it also increases bleeding.	dapt	54-58	purinergic receptor P2Y12	Homo sapiens	89-94
30522654-2	2018	Prescribers of DAPT are confronted with a number of challenges that include selecting the appropriate P2Y12 inhibitor and determining the optimal duration of DAPT with the scope of minimizing the risk of ischemic and bleeding complications in light of each patient"s clinical characteristic and circumstance.	dapt	15-19	purinergic receptor P2Y12	Homo sapiens	102-107
30251655-8	2018	RESULTS: We have observed changes in the levels of miR-212/132 after administrating DAPT to zebrafish embryos indicating that this pathway could be regulating mu opioid receptor expression.	dapt	84-88	microRNA 212	Danio rerio	51-58
30251655-9	2018	In addition, the ISH experiment showed changes in Notch1 expression after morphine and DAPT administration.	dapt	87-91	notch receptor 1a	Danio rerio	50-56
30483127-7	2018	Meanwhile, overexpression of Notch1 suppressed and inhibition of Notch1 promoted rosiglitazone-induced adipogenic differentiation in TSCs, and the pro-adipogenic effects of the Notch inhibitor DAPT were associated with the activation of autophagy.	dapt	193-197	notch receptor 1	Homo sapiens	29-35
30483127-7	2018	Meanwhile, overexpression of Notch1 suppressed and inhibition of Notch1 promoted rosiglitazone-induced adipogenic differentiation in TSCs, and the pro-adipogenic effects of the Notch inhibitor DAPT were associated with the activation of autophagy.	dapt	193-197	notch receptor 1	Homo sapiens	65-71
30483127-7	2018	Meanwhile, overexpression of Notch1 suppressed and inhibition of Notch1 promoted rosiglitazone-induced adipogenic differentiation in TSCs, and the pro-adipogenic effects of the Notch inhibitor DAPT were associated with the activation of autophagy.	dapt	193-197	notch receptor 1	Homo sapiens	29-34
30510400-6	2018	The present study was designed to determine the effect of Notch inhibitor DAPT upon oxidation stress for brain edema after TBI.	dapt	74-78	notch receptor 1	Rattus norvegicus	58-63
30510400-9	2018	Results: Our data indicated that Notch signaling inhibitor DAPT significantly reduced the ADC values and improved the neurological function after TBI.	dapt	59-63	notch receptor 1	Rattus norvegicus	33-38
30510400-10	2018	In addition, DAPT decreased NOX2 levels and the ROS levels.	dapt	13-17	cytochrome b-245 beta chain	Rattus norvegicus	28-32
30243963-7	2018	DAPT switch from 1 P2Y12 inhibitor to another occurred in 9%, either in-hospital or at discharge.	dapt	0-4	purinergic receptor P2Y12	Homo sapiens	19-24
30218844-6	2018	After 3 months treatment with DAPT (except those on anticoagulant in whom aspirin is optional), subjects free from stroke, MI, revascularization or ST will be eligible to discontinue P2Y12 inhibitor, but continue aspirin.	dapt	30-34	purinergic receptor P2Y12	Homo sapiens	183-188
30367520-7	2018	Western blot revealed that DAPT inhibited p65 phosphorylation and acetylation, and the p65 and p50 levels in the nucleus decreased.	dapt	27-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	42-45
30498687-1	2018	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is key for secondary prevention of recurrent coronary ischemic events and stent thrombosis.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
29885287-11	2018	We demonstrated that treatment with the chemical Notch inhibitor DAPT increased mKi67 and Olig2 mRNA expression while decreasing astroglial Gfap expression, suggesting Notch signaling regulates both proliferation and early glial fate decisions.	dapt	65-69	antigen identified by monoclonal antibody Ki 67	Mus musculus	80-85
29885287-11	2018	We demonstrated that treatment with the chemical Notch inhibitor DAPT increased mKi67 and Olig2 mRNA expression while decreasing astroglial Gfap expression, suggesting Notch signaling regulates both proliferation and early glial fate decisions.	dapt	65-69	oligodendrocyte transcription factor 2	Mus musculus	90-95
29885287-11	2018	We demonstrated that treatment with the chemical Notch inhibitor DAPT increased mKi67 and Olig2 mRNA expression while decreasing astroglial Gfap expression, suggesting Notch signaling regulates both proliferation and early glial fate decisions.	dapt	65-69	glial fibrillary acidic protein	Mus musculus	140-144
30015856-5	2018	It was also identified that blocking Notch signalling with the g-secretase inhibitor DAPT decreased the expression of the EMT markers Snail and vimentin and increased E-cadherin expression, accompanied by a significant inhibition of cell migration in the 2 OSCC cell lines.	dapt	85-89	snail family transcriptional repressor 1	Homo sapiens	134-139
30015856-5	2018	It was also identified that blocking Notch signalling with the g-secretase inhibitor DAPT decreased the expression of the EMT markers Snail and vimentin and increased E-cadherin expression, accompanied by a significant inhibition of cell migration in the 2 OSCC cell lines.	dapt	85-89	vimentin	Homo sapiens	144-152
30015856-5	2018	It was also identified that blocking Notch signalling with the g-secretase inhibitor DAPT decreased the expression of the EMT markers Snail and vimentin and increased E-cadherin expression, accompanied by a significant inhibition of cell migration in the 2 OSCC cell lines.	dapt	85-89	cadherin 1	Homo sapiens	167-177
30196308-12	2018	RESULTS Oxymatrine and Notch signaling pathway inhibitor DAPT could attenuated TGF-beta1 induced the capacity of proliferation and migration increased in cardiac fibroblasts, as well as the secretion of collagen and hydroxyproline colorimetric content in medium.	dapt	57-61	notch receptor 1	Rattus norvegicus	23-28
30238704-1	2018	Dual antiplatelet therapy (DAPT) - a combination of a P2Y12 receptor inhibitor and aspirin - has revolutionized antithrombotic treatment.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	54-59
30309512-7	2018	The reduced levels of Notch intracellular domain (NICD) protein were observed in the DAPT-treated cells, thereby bringing about the down-regulation of ICBP90 with the increment of the DAPT dose.	dapt	85-89	UHRF1 binding protein 1	Homo sapiens	151-157
30309512-7	2018	The reduced levels of Notch intracellular domain (NICD) protein were observed in the DAPT-treated cells, thereby bringing about the down-regulation of ICBP90 with the increment of the DAPT dose.	dapt	184-188	UHRF1 binding protein 1	Homo sapiens	151-157
30237561-6	2018	Podocyte injury in vitro was induced by high-glucose concentration, and expression levels of genes associated with the Notch-1 pathway were also regulated by Jagged-1/FC and N-[N-(3,5-Difluorophenacetyl)-L-alanyl]- S-phenylglycine t-butyl ester (DAPT).	dapt	246-250	notch receptor 1	Rattus norvegicus	119-126
30237561-6	2018	Podocyte injury in vitro was induced by high-glucose concentration, and expression levels of genes associated with the Notch-1 pathway were also regulated by Jagged-1/FC and N-[N-(3,5-Difluorophenacetyl)-L-alanyl]- S-phenylglycine t-butyl ester (DAPT).	dapt	246-250	jagged canonical Notch ligand 1	Rattus norvegicus	158-166
30196308-12	2018	RESULTS Oxymatrine and Notch signaling pathway inhibitor DAPT could attenuated TGF-beta1 induced the capacity of proliferation and migration increased in cardiac fibroblasts, as well as the secretion of collagen and hydroxyproline colorimetric content in medium.	dapt	57-61	transforming growth factor, beta 1	Rattus norvegicus	79-88
30196308-13	2018	TGF-beta1 induced the biomarker alpha-SMA of fibroblast-to-myofibroblast transformation (FMT), which was inhibited by oxymatrine and DAPT.	dapt	133-137	transforming growth factor, beta 1	Rattus norvegicus	0-9
29956731-11	2018	Additionally, the combination of quercetin-3-methyl ether and a secretase inhibitor (DAPT) exhibited additive suppression of the expression of Notch1, PI3K, Akt and mammalian target of rapamycin and a more marked inhibitory effect on cell proliferation and colony formation compared with either drug alone.	dapt	85-89	notch receptor 1	Homo sapiens	143-149
29930007-5	2018	We, therefore, investigated vascular endothelial-cadherin (VEC) phosphorylation because this is a common downstream target of low shear stress and DAPT treatment.	dapt	147-151	cadherin 5	Homo sapiens	28-57
29930007-5	2018	We, therefore, investigated vascular endothelial-cadherin (VEC) phosphorylation because this is a common downstream target of low shear stress and DAPT treatment.	dapt	147-151	cadherin 5	Homo sapiens	59-62
29930007-6	2018	VEC phosphorylation increases after DAPT treatment and decreased shear stress.	dapt	36-40	cadherin 5	Homo sapiens	0-3
29930007-8	2018	Increasing shear stress rescues hyperfusion by DAPT treatment by causing the association of the phosphatase vascular endothelial-protein tyrosine phosphatase with VEC, counteracting VEC phosphorylation.	dapt	47-51	cadherin 5	Homo sapiens	163-166
29930007-8	2018	Increasing shear stress rescues hyperfusion by DAPT treatment by causing the association of the phosphatase vascular endothelial-protein tyrosine phosphatase with VEC, counteracting VEC phosphorylation.	dapt	47-51	cadherin 5	Homo sapiens	182-185
29930007-9	2018	Finally, Src (proto-oncogene tyrosine-protein kinase Src) inhibition prevents VEC phosphorylation in endothelial cells and can rescue hyperfusion induced by low shear stress and DAPT treatment.	dapt	178-182	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-12
29930007-9	2018	Finally, Src (proto-oncogene tyrosine-protein kinase Src) inhibition prevents VEC phosphorylation in endothelial cells and can rescue hyperfusion induced by low shear stress and DAPT treatment.	dapt	178-182	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-56
29930007-9	2018	Finally, Src (proto-oncogene tyrosine-protein kinase Src) inhibition prevents VEC phosphorylation in endothelial cells and can rescue hyperfusion induced by low shear stress and DAPT treatment.	dapt	178-182	cadherin 5	Homo sapiens	78-81
29930007-11	2018	Conclusions- This study provides the first evidence that VEC phosphorylation, induced by DAPT treatment and low shear stress, is involved in the process of fusion during vascular remodeling.	dapt	89-93	cadherin 5	Homo sapiens	57-60
29956731-11	2018	Additionally, the combination of quercetin-3-methyl ether and a secretase inhibitor (DAPT) exhibited additive suppression of the expression of Notch1, PI3K, Akt and mammalian target of rapamycin and a more marked inhibitory effect on cell proliferation and colony formation compared with either drug alone.	dapt	85-89	AKT serine/threonine kinase 1	Homo sapiens	157-160
29956731-11	2018	Additionally, the combination of quercetin-3-methyl ether and a secretase inhibitor (DAPT) exhibited additive suppression of the expression of Notch1, PI3K, Akt and mammalian target of rapamycin and a more marked inhibitory effect on cell proliferation and colony formation compared with either drug alone.	dapt	85-89	mechanistic target of rapamycin kinase	Homo sapiens	165-194
30188374-3	2018	This study aimed to assess the effect of genetic polymorphisms in PON-1, PEAR-1, P2Y12, CES1, and CYP2C19, along with clinical, demographic, and social factors, on variation in response to DAPT in Egyptians.	dapt	189-193	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	98-105
29076782-6	2018	N-[ N-(3,5-difluorophenacetyl)-l-alanyl]- S-phenylglycine t-butyl ester (DAPT) was injected into the lateral ventricle to block Notch-1 signaling.	dapt	73-77	notch receptor 1	Rattus norvegicus	128-135
29076782-10	2018	Remarkably, blockade of Notch-1 signaling with the specific inhibitor DAPT suppressed astrocytic proliferation and GFAP levels caused by ICH.	dapt	70-74	notch receptor 1	Rattus norvegicus	24-31
30015939-6	2018	Additionally, 1,25(OH)2D3 and/or DAPT reduced the expression of Notch1, Notch2, Jagged1 and Jagged2.	dapt	33-37	notch receptor 1	Homo sapiens	64-70
30015939-6	2018	Additionally, 1,25(OH)2D3 and/or DAPT reduced the expression of Notch1, Notch2, Jagged1 and Jagged2.	dapt	33-37	notch receptor 2	Homo sapiens	72-78
30015939-6	2018	Additionally, 1,25(OH)2D3 and/or DAPT reduced the expression of Notch1, Notch2, Jagged1 and Jagged2.	dapt	33-37	jagged canonical Notch ligand 1	Homo sapiens	80-87
30015939-6	2018	Additionally, 1,25(OH)2D3 and/or DAPT reduced the expression of Notch1, Notch2, Jagged1 and Jagged2.	dapt	33-37	jagged canonical Notch ligand 2	Homo sapiens	92-99
29052493-9	2018	The results demonstrated that DAPT led to minimal impact on aspirin esterase activity but significant decrease in rCyp2c11 activity and mRNA expression.	dapt	30-34	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	114-122
29052493-11	2018	In conclusion, our findings on impairment in rCyp2C11 activity and mRNA expression by DAPT in rats could provide guidance on its safe clinical use with other CYP 2C19 substrates.	dapt	86-90	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	45-53
30131677-8	2018	Inhibiting Notch1 signaling at day 4 after reperfusion with DAPT further promoted recovery of MRI parameters of the corticospinal tract (CST) and the functional outcomes, concomitantly with an increase in neuroblasts, their migration to the ischemic boundary, and potential differentiation to mature neurons, as well as the amelioration of axonal bundle integrity.	dapt	60-64	notch receptor 1	Rattus norvegicus	11-17
29488214-6	2018	As a result, pharmacological inhibition of the Notch pathway using gamma-secretase inhibitor (GSI), DAPT, downregulated both phospho-p38 and Bcl-2 expression and significantly enhanced the efficacy of ADT in androgen sensitive PCa cells with impaired proliferation and 3D colony formation, increased apoptosis and remarkable inhibition of tumor growth in murine subcutaneous xenograft model.	dapt	100-104	notch receptor 3	Homo sapiens	47-52
29488214-6	2018	As a result, pharmacological inhibition of the Notch pathway using gamma-secretase inhibitor (GSI), DAPT, downregulated both phospho-p38 and Bcl-2 expression and significantly enhanced the efficacy of ADT in androgen sensitive PCa cells with impaired proliferation and 3D colony formation, increased apoptosis and remarkable inhibition of tumor growth in murine subcutaneous xenograft model.	dapt	100-104	B cell leukemia/lymphoma 2	Mus musculus	141-146
29266203-6	2018	We observed that the dose of DAPT used was ineffective to reduce ovarian tumor growth, but showed anticancer activity when co-administered with recombinant PDGFB.	dapt	29-33	platelet derived growth factor subunit B	Homo sapiens	156-161
29266203-8	2018	Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT.	dapt	81-85	platelet derived growth factor subunit B	Homo sapiens	38-43
29266203-9	2018	Our findings suggest that PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor.	dapt	105-109	platelet derived growth factor subunit B	Homo sapiens	26-31
29602648-1	2018	Dual antiplatelet therapy (DAPT) with a P2Y12 receptor antagonist in addition to aspirin is the antiplatelet treatment of choice in patients undergoing percutaneous coronary intervention.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	40-45
30042932-7	2018	Inhibition of Notch signaling by gamma-secretase inhibitor DAPT impairs TLR4-stimulated accumulation of NF-kappaB subunits p65 in the nucleus and subsequently reduces LPS- and infection-mediated IL-6 production.	dapt	59-63	toll like receptor 4	Homo sapiens	72-76
30042932-7	2018	Inhibition of Notch signaling by gamma-secretase inhibitor DAPT impairs TLR4-stimulated accumulation of NF-kappaB subunits p65 in the nucleus and subsequently reduces LPS- and infection-mediated IL-6 production.	dapt	59-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	123-126
30042932-7	2018	Inhibition of Notch signaling by gamma-secretase inhibitor DAPT impairs TLR4-stimulated accumulation of NF-kappaB subunits p65 in the nucleus and subsequently reduces LPS- and infection-mediated IL-6 production.	dapt	59-63	interleukin 6	Homo sapiens	195-199
30230583-4	2018	VEGF (100 ng/mL) and gamma-secretase inhibitor (DAPT) (10 muM) was used to active and inhibit VEGF-Notch signaling in AA MSCs, respectively.	dapt	48-52	vascular endothelial growth factor A	Homo sapiens	94-98
30230583-4	2018	VEGF (100 ng/mL) and gamma-secretase inhibitor (DAPT) (10 muM) was used to active and inhibit VEGF-Notch signaling in AA MSCs, respectively.	dapt	48-52	notch receptor 1	Homo sapiens	99-104
30188374-9	2018	CONCLUSION: These results highlight that CYP2C19*2, along with diabetes, and use of proton pump inhibitor and statin are important factors jointly associated with variability in clinical response to DAPT following ACS in Egyptians.	dapt	199-203	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	41-48
29968428-1	2018	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is essential after percutaneous coronary intervention (PCI), while many studies have focused on determining the optimal degree of platelet inhibition and optimal DAPT duration to minimize complications after PCI.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
29779621-10	2018	DAPT treatment partially rescued the elevated mRNA expression and immuno-positive cell numbers of Notch1, Jagged1 and Hes5.	dapt	0-4	notch 1	Mus musculus	98-104
29779621-10	2018	DAPT treatment partially rescued the elevated mRNA expression and immuno-positive cell numbers of Notch1, Jagged1 and Hes5.	dapt	0-4	jagged 1	Mus musculus	106-113
29779621-10	2018	DAPT treatment partially rescued the elevated mRNA expression and immuno-positive cell numbers of Notch1, Jagged1 and Hes5.	dapt	0-4	hes family bHLH transcription factor 5	Mus musculus	118-122
29779621-13	2018	Inhibiting Notch signaling activation by DAPT can partially delay the progress of TMJOA.	dapt	41-45	notch 1	Mus musculus	11-16
29781034-9	2018	Thus Notch-3 appears to be a promising target for gene therapy and DAPT is able to mediate a strong antitumor effect in NSCLC cells that overexpress Notch-3.	dapt	67-71	notch receptor 3	Homo sapiens	149-156
29743380-1	2018	BACKGROUND: Patients with reduced-function CYP2C19 genotypes on dual antiplatelet therapy (DAPT) with aspirin and clopidogrel show higher clinical risk for acute myocardial infarction (AMI).	dapt	91-95	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	43-50
29720422-6	2018	Notch inhibition using the gamma-secretase inhibitor DAPT impaired renal inflammatory cell infiltration and proinflammatory cytokines overexpression in Gremlin-injected mice and in experimental models of renal injury.	dapt	53-57	gremlin 1, DAN family BMP antagonist	Homo sapiens	152-159
28815510-5	2018	Similar increases in PS1 were evident in primary neurons treated repeatedly (4 days) with DAPT or with the GSI BMS-708163 (avagacestat).	dapt	90-94	presenilin 1	Rattus norvegicus	21-24
29571073-10	2018	In vivo combined treatment of anti-DLL4 and DAPT led to a higher rate of cell apoptosis and greater inhibition of cell invasion than that observed with DAPT treatment alone.	dapt	152-156	delta like canonical Notch ligand 4	Homo sapiens	35-39
29571073-12	2018	In vivo combined therapy with anti-DLL4 and DAPT significantly increased tumor growth inhibition and tumor cell apoptosis when compared to DAPT therapy alone (P < .05).	dapt	139-143	delta like canonical Notch ligand 4	Homo sapiens	35-39
30151432-8	2018	HESCs were treated with N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) and valproic acid (VPA) to, respectively, suppress and induce Notch-1 activation.	dapt	24-93	notch receptor 1	Homo sapiens	163-170
29571073-14	2018	Conversely, treatment with DAPT alone only increased expression of BAX and P53 (P < .05), suggesting that the reduction of Bcl-2 expression may play an important role in the synergetic antitumor and proapoptosis effects of the combined treatment.	dapt	27-31	BCL2 associated X, apoptosis regulator	Homo sapiens	67-70
29571073-14	2018	Conversely, treatment with DAPT alone only increased expression of BAX and P53 (P < .05), suggesting that the reduction of Bcl-2 expression may play an important role in the synergetic antitumor and proapoptosis effects of the combined treatment.	dapt	27-31	tumor protein p53	Homo sapiens	75-78
29571073-14	2018	Conversely, treatment with DAPT alone only increased expression of BAX and P53 (P < .05), suggesting that the reduction of Bcl-2 expression may play an important role in the synergetic antitumor and proapoptosis effects of the combined treatment.	dapt	27-31	BCL2 apoptosis regulator	Homo sapiens	126-131
30151432-13	2018	In HESCs, DAPT reduction of NICD1 decreased cell numbers and increased PGR transcript and nuclear PGR protein levels and, with P cotreatment, maintained P sensitivity.	dapt	10-14	progesterone receptor	Homo sapiens	71-74
30151432-13	2018	In HESCs, DAPT reduction of NICD1 decreased cell numbers and increased PGR transcript and nuclear PGR protein levels and, with P cotreatment, maintained P sensitivity.	dapt	10-14	progesterone receptor	Homo sapiens	98-101
29739946-3	2018	Here, using a chemically defined hPSC differentiation system combined with the use of DLL1-Fc and DAPT to manipulate NOTCH, we discover that NOTCH activation in hPSC-derived immature HE progenitors leads to formation of CD144+CD43-CD73-DLL4+Runx1 + 23-GFP+ arterial-type HE, which requires NOTCH signaling to undergo endothelial-to-hematopoietic transition and produce definitive lympho-myeloid and erythroid cells.	dapt	98-102	sialophorin	Homo sapiens	226-230
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P<0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P>0.05).	dapt	72-76	notch 1	Mus musculus	141-147
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P<0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P>0.05).	dapt	82-86	notch 1	Mus musculus	141-147
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P<0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P>0.05).	dapt	82-86	notch 1	Mus musculus	269-276
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P<0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P>0.05).	dapt	82-86	notch 2	Mus musculus	414-421
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P<0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P>0.05).	dapt	82-86	notch 1	Mus musculus	141-147
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P<0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P>0.05).	dapt	82-86	notch 1	Mus musculus	269-276
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P<0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P>0.05).	dapt	82-86	notch 2	Mus musculus	414-421
29804421-5	2018	Both DAPT and curcumin-PDT can inhibit the protein expression of Notch1, NF-kappaB and VEGF, and two of them have synergistic effect after combined use.	dapt	5-9	notch 1	Mus musculus	65-71
29804421-5	2018	Both DAPT and curcumin-PDT can inhibit the protein expression of Notch1, NF-kappaB and VEGF, and two of them have synergistic effect after combined use.	dapt	5-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
29804421-5	2018	Both DAPT and curcumin-PDT can inhibit the protein expression of Notch1, NF-kappaB and VEGF, and two of them have synergistic effect after combined use.	dapt	5-9	vascular endothelial growth factor A	Mus musculus	87-91
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	13-17	notch receptor 1	Homo sapiens	44-49
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	13-17	notch receptor 1	Homo sapiens	168-173
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	13-17	notch 1	Mus musculus	319-325
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	13-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	330-339
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	13-17	notch receptor 1	Homo sapiens	168-173
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	152-156	notch receptor 1	Homo sapiens	44-49
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	152-156	notch receptor 1	Homo sapiens	168-173
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	152-156	notch 1	Mus musculus	319-325
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	152-156	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	330-339
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	dapt	152-156	notch receptor 1	Homo sapiens	168-173
29867564-10	2018	Using DAPT, we confirmed the involvement of G1/Notch signaling in limiting infarct size in heart of normotensive animals.	dapt	6-10	notch receptor 1	Rattus norvegicus	47-52
29804421-0	2018	[Inhibitory effect of DAPT on Notch signaling pathway in curcumin mediated photodynamic therapy for cervical cancer xenografts in nude mice].	dapt	22-26	notch receptor 1	Homo sapiens	30-35
29739946-3	2018	Here, using a chemically defined hPSC differentiation system combined with the use of DLL1-Fc and DAPT to manipulate NOTCH, we discover that NOTCH activation in hPSC-derived immature HE progenitors leads to formation of CD144+CD43-CD73-DLL4+Runx1 + 23-GFP+ arterial-type HE, which requires NOTCH signaling to undergo endothelial-to-hematopoietic transition and produce definitive lympho-myeloid and erythroid cells.	dapt	98-102	5'-nucleotidase ecto	Homo sapiens	231-235
29739946-3	2018	Here, using a chemically defined hPSC differentiation system combined with the use of DLL1-Fc and DAPT to manipulate NOTCH, we discover that NOTCH activation in hPSC-derived immature HE progenitors leads to formation of CD144+CD43-CD73-DLL4+Runx1 + 23-GFP+ arterial-type HE, which requires NOTCH signaling to undergo endothelial-to-hematopoietic transition and produce definitive lympho-myeloid and erythroid cells.	dapt	98-102	delta like canonical Notch ligand 4	Homo sapiens	236-240
29739946-3	2018	Here, using a chemically defined hPSC differentiation system combined with the use of DLL1-Fc and DAPT to manipulate NOTCH, we discover that NOTCH activation in hPSC-derived immature HE progenitors leads to formation of CD144+CD43-CD73-DLL4+Runx1 + 23-GFP+ arterial-type HE, which requires NOTCH signaling to undergo endothelial-to-hematopoietic transition and produce definitive lympho-myeloid and erythroid cells.	dapt	98-102	RUNX family transcription factor 1	Homo sapiens	241-246
29383634-10	2018	Pharmaceutical blockage of Notch signaling using gamma-secretase inhibitor DAPT abrogated the DLK1-EC-induced endothelial migration and Hes-1-driven luciferase activities.	dapt	75-79	notch receptor 1	Rattus norvegicus	27-32
29297976-1	2018	The current guidelines following an acute coronary syndrome recommend dual-antiplatelet therapy (DAPT) (aspirin plus a P2Y12 antagonist) alongside lifestyle modifications, including more regular physical activity.	dapt	97-101	purinergic receptor P2Y12	Homo sapiens	119-124
29383634-10	2018	Pharmaceutical blockage of Notch signaling using gamma-secretase inhibitor DAPT abrogated the DLK1-EC-induced endothelial migration and Hes-1-driven luciferase activities.	dapt	75-79	delta like non-canonical Notch ligand 1	Rattus norvegicus	94-98
29383634-10	2018	Pharmaceutical blockage of Notch signaling using gamma-secretase inhibitor DAPT abrogated the DLK1-EC-induced endothelial migration and Hes-1-driven luciferase activities.	dapt	75-79	hes family bHLH transcription factor 1	Rattus norvegicus	136-141
29853716-1	2018	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS) and/or receiving coronary stents.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
29867293-1	2018	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of pharmacologic management of patients with acute coronary syndrome (ACS) and/or those receiving coronary stents.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
29230705-11	2018	Silencing of Notch1 signaling with inhibitor DAPT, NF-kappaB activation and LPS-induced inflammatory response were obviously attenuated, whereas Notch1 activator Jagged1 could markedly restore NF-kappaB activity and LPS-induced inflammatory response (P < 0.05 for all).	dapt	45-49	notch receptor 1	Homo sapiens	13-19
29674611-5	2018	Then, DAPT, a classical gamma-secretase inhibitor, was applied to specifically inhibit Notch1 activation, followed by up-regulation of vascular endothelial growth factor receptor 2 (VEGFR2) and CD31 expression.	dapt	6-10	notch receptor 1	Rattus norvegicus	87-93
29674611-5	2018	Then, DAPT, a classical gamma-secretase inhibitor, was applied to specifically inhibit Notch1 activation, followed by up-regulation of vascular endothelial growth factor receptor 2 (VEGFR2) and CD31 expression.	dapt	6-10	kinase insert domain receptor	Rattus norvegicus	135-180
29674611-5	2018	Then, DAPT, a classical gamma-secretase inhibitor, was applied to specifically inhibit Notch1 activation, followed by up-regulation of vascular endothelial growth factor receptor 2 (VEGFR2) and CD31 expression.	dapt	6-10	kinase insert domain receptor	Rattus norvegicus	182-188
29674611-5	2018	Then, DAPT, a classical gamma-secretase inhibitor, was applied to specifically inhibit Notch1 activation, followed by up-regulation of vascular endothelial growth factor receptor 2 (VEGFR2) and CD31 expression.	dapt	6-10	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	194-198
29642547-2	2018	Such treatment is followed by dual antiplatelet therapy (DAPT) comprising of aspirin and a P2Y12 inhibitor.	dapt	57-61	purinergic receptor P2Y12	Homo sapiens	91-96
30079092-5	2018	We constructed lentivirus for overexpressing miR-1 and used DAPT, an antagonist of the Notch1 pathway, for in vitro analyses.	dapt	60-64	notch receptor 1	Rattus norvegicus	87-93
29615454-11	2018	CONCLUSIONS: Implementing CYP2C19 genotype-guided DAPT is feasible and sustainable in a real-world setting but challenging to maintain at a consistently high level of fidelity.	dapt	50-54	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	26-33
29615454-12	2018	The higher risk of major adverse cardiovascular or cerebrovascular associated with clopidogrel use in CYP2C19 LOF allele carriers suggests that use of genotype-guided DAPT in practice may improve clinical outcomes.	dapt	167-171	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	102-109
29451718-8	2018	The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling.	dapt	20-24	notch receptor 1	Homo sapiens	4-9
29451718-8	2018	The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling.	dapt	20-24	sushi domain containing 6	Homo sapiens	59-67
29451718-8	2018	The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling.	dapt	20-24	sushi domain containing 6	Homo sapiens	95-103
29451718-8	2018	The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling.	dapt	20-24	notch receptor 1	Homo sapiens	181-186
29417442-12	2018	The combination of DAPT and ATRA effectively increased the proportion of apoptotic cells and the level of caspase 3/7 activities compared to single treatment.	dapt	19-23	caspase 3	Homo sapiens	106-115
29417442-13	2018	Moreover, augmented caspase-3 up-regulation and bcl-2 down-regulation were found following combined application of DAPT and ATRA.	dapt	115-119	caspase 3	Homo sapiens	20-29
29417442-13	2018	Moreover, augmented caspase-3 up-regulation and bcl-2 down-regulation were found following combined application of DAPT and ATRA.	dapt	115-119	BCL2 apoptosis regulator	Homo sapiens	48-53
29393429-10	2018	DAPT increased the expression of epithelial-cadherin and decreased the content of neural-cadherin, Snail and invasion in MiaPaCa2 cells in the presence or absence of CoCl2.	dapt	0-4	cadherin 1	Homo sapiens	33-52
29455246-3	2018	Using a recently developed thermosensitive cell line (IDG-SW3), we demonstrated that dentin matrix acidic phosphoprotein 1 (DMP1) expression was inhibited and mineralisation process was significantly altered when Notch pathway was inactivated via administration of N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), an inhibitor of Notch.	dapt	265-334	dentin matrix acidic phosphoprotein 1	Homo sapiens	85-122
29455246-3	2018	Using a recently developed thermosensitive cell line (IDG-SW3), we demonstrated that dentin matrix acidic phosphoprotein 1 (DMP1) expression was inhibited and mineralisation process was significantly altered when Notch pathway was inactivated via administration of N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), an inhibitor of Notch.	dapt	265-334	dentin matrix acidic phosphoprotein 1	Homo sapiens	124-128
29455246-3	2018	Using a recently developed thermosensitive cell line (IDG-SW3), we demonstrated that dentin matrix acidic phosphoprotein 1 (DMP1) expression was inhibited and mineralisation process was significantly altered when Notch pathway was inactivated via administration of N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), an inhibitor of Notch.	dapt	336-340	dentin matrix acidic phosphoprotein 1	Homo sapiens	85-122
29455246-3	2018	Using a recently developed thermosensitive cell line (IDG-SW3), we demonstrated that dentin matrix acidic phosphoprotein 1 (DMP1) expression was inhibited and mineralisation process was significantly altered when Notch pathway was inactivated via administration of N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), an inhibitor of Notch.	dapt	336-340	dentin matrix acidic phosphoprotein 1	Homo sapiens	124-128
29393429-10	2018	DAPT increased the expression of epithelial-cadherin and decreased the content of neural-cadherin, Snail and invasion in MiaPaCa2 cells in the presence or absence of CoCl2.	dapt	0-4	cadherin 2	Homo sapiens	82-97
29393429-10	2018	DAPT increased the expression of epithelial-cadherin and decreased the content of neural-cadherin, Snail and invasion in MiaPaCa2 cells in the presence or absence of CoCl2.	dapt	0-4	snail family transcriptional repressor 1	Homo sapiens	99-104
29544699-13	2018	Clopidogrel was used as a P2Y12 inhibitor for DAPT in 1082 (79 7%) patients in the 6-month DAPT group and in 1109 (81 8%) patients in the 12-month or longer DAPT group.	dapt	46-50	purinergic receptor P2Y12	Homo sapiens	26-31
29584740-9	2018	RESULTS: The addition of Panax quinquefolius saponins (PQS+DAPT) to standard DAPT therapy significantly decreased the myocardial infarct area, degree of myocardial lesions, TXB2 and PAI levels, and the TXB2/6-keto-PGF1alpha ratio, while increasing 6-keto-PGF1alpha and t-PA levels and reducing the degree of gastric mucosal injury.	dapt	59-63	serpin family E member 1	Rattus norvegicus	182-185
29584740-10	2018	Expression of PGE2, 6-keto-PGF1alpha, COX-2, and VEGF in the gastric mucosa was upregulated in the PQS+DAPT group compared with the standard DAPT group.	dapt	103-107	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	38-43
29584740-10	2018	Expression of PGE2, 6-keto-PGF1alpha, COX-2, and VEGF in the gastric mucosa was upregulated in the PQS+DAPT group compared with the standard DAPT group.	dapt	103-107	vascular endothelial growth factor A	Rattus norvegicus	49-53
29686529-5	2018	DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORgammat and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance.	dapt	0-4	interleukin 17A	Homo sapiens	120-125
29523162-3	2018	In this study, our aim was to evaluate the possible inhibitory effect of Notch1 signaling inhibitor, gamma-secretase inhibitor DAPT, on psoriatic Th17 cell differentiation and function in a mouse model of psoriasis-like skin inflammation.	dapt	127-131	notch receptor 1	Homo sapiens	73-79
29523162-12	2018	Data obtained from in vitro study in IMQ-treated mice also demonstrated that blocking Notch1 signaling by DAPT can result in a dose-dependent decrease of Th17 cell proportion, mRNA expression of Notch1, Hes-1, RORgammat and IL-17A as well as IL-17A secretion in splenic CD4+ T cells.	dapt	106-110	notch 1	Mus musculus	86-92
29523162-12	2018	Data obtained from in vitro study in IMQ-treated mice also demonstrated that blocking Notch1 signaling by DAPT can result in a dose-dependent decrease of Th17 cell proportion, mRNA expression of Notch1, Hes-1, RORgammat and IL-17A as well as IL-17A secretion in splenic CD4+ T cells.	dapt	106-110	notch 1	Mus musculus	195-201
29523162-12	2018	Data obtained from in vitro study in IMQ-treated mice also demonstrated that blocking Notch1 signaling by DAPT can result in a dose-dependent decrease of Th17 cell proportion, mRNA expression of Notch1, Hes-1, RORgammat and IL-17A as well as IL-17A secretion in splenic CD4+ T cells.	dapt	106-110	hes family bHLH transcription factor 1	Mus musculus	203-208
29523162-12	2018	Data obtained from in vitro study in IMQ-treated mice also demonstrated that blocking Notch1 signaling by DAPT can result in a dose-dependent decrease of Th17 cell proportion, mRNA expression of Notch1, Hes-1, RORgammat and IL-17A as well as IL-17A secretion in splenic CD4+ T cells.	dapt	106-110	interleukin 17A	Mus musculus	224-230
29523162-12	2018	Data obtained from in vitro study in IMQ-treated mice also demonstrated that blocking Notch1 signaling by DAPT can result in a dose-dependent decrease of Th17 cell proportion, mRNA expression of Notch1, Hes-1, RORgammat and IL-17A as well as IL-17A secretion in splenic CD4+ T cells.	dapt	106-110	interleukin 17A	Mus musculus	242-248
29523162-13	2018	CONCLUSION: These data suggest that Notch1 inhibition by DAPT can effectively alleviate the severity of mouse psoriasis-like skin inflammation by regulating the differentiation and function of Th17 cells, indicating that DAPT might be a potential therapeutic candidate for the treatment of psoriatic inflammation.	dapt	57-61	notch 1	Mus musculus	36-42
29523162-13	2018	CONCLUSION: These data suggest that Notch1 inhibition by DAPT can effectively alleviate the severity of mouse psoriasis-like skin inflammation by regulating the differentiation and function of Th17 cells, indicating that DAPT might be a potential therapeutic candidate for the treatment of psoriatic inflammation.	dapt	221-225	notch 1	Mus musculus	36-42
29686529-5	2018	DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORgammat and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance.	dapt	0-4	interleukin 17A	Homo sapiens	143-148
29686529-5	2018	DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORgammat and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance.	dapt	0-4	forkhead box P3	Homo sapiens	326-331
29686529-5	2018	DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORgammat and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance.	dapt	0-4	interleukin 10	Homo sapiens	337-342
29047105-5	2018	Notch signaling inhibition using a gamma-secretase inhibitor (GSI-IX, DAPT) decreased tumour burden in the mouse model after prophylactic treatment.	dapt	62-68	notch receptor 1	Homo sapiens	0-5
29338536-1	2018	INTRODUCTION: P2Y12 inhibitors are a critical component of dual antiplatelet therapy (DAPT), which is the superior strategy to prevent arterialthrombosis in patients with acute coronary syndromes (ACS) and undergoing stent implantation.. Areas covered: Basic science articles, clinical studies, and reviews from 1992-2017 were searched using Pubmed library to collet impactful literature.	dapt	86-90	purinergic receptor P2Y12	Homo sapiens	14-19
29447787-1	2018	BACKGROUND AND RATIONALE: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor reduces thrombotic events in patients undergoing percutaneous coronary intervention (PCI), but these benefits come at the expense of increased risk of bleeding when compared with aspirin monotherapy.	dapt	53-57	purinergic receptor P2Y12	Homo sapiens	78-83
29047105-5	2018	Notch signaling inhibition using a gamma-secretase inhibitor (GSI-IX, DAPT) decreased tumour burden in the mouse model after prophylactic treatment.	dapt	70-74	notch receptor 1	Homo sapiens	0-5
29515364-5	2018	In the present study, we treated cochleae from postnatal day 0 (P0) with the Notch signaling inhibitor DAPT and observed apparent SC-to-HC conversion along with E-cadherin/p120ctn disruption in the sensory region.	dapt	103-107	cadherin 1	Homo sapiens	161-171
29286081-12	2018	Furthermore, inhibition of Notch1 signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (inhibitor of Notch signaling) counteracted the effects of Ficz on the development of TJs in hypoxic Caco-2 cells.	dapt	47-116	notch receptor 1	Homo sapiens	27-33
29286081-12	2018	Furthermore, inhibition of Notch1 signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (inhibitor of Notch signaling) counteracted the effects of Ficz on the development of TJs in hypoxic Caco-2 cells.	dapt	47-116	notch receptor 1	Homo sapiens	27-32
29286145-10	2018	These effects were further confirmed by the Notch-1 inhibitor DAPT.	dapt	62-66	notch receptor 1	Homo sapiens	44-51
29515364-5	2018	In the present study, we treated cochleae from postnatal day 0 (P0) with the Notch signaling inhibitor DAPT and observed apparent SC-to-HC conversion along with E-cadherin/p120ctn disruption in the sensory region.	dapt	103-107	catenin delta 1	Homo sapiens	172-179
29515364-7	2018	We further demonstrated that the ability to regenerate HCs and the disruption of E-cadherin/p120ctn concomitantly decreased with age and ceased at P7, even after extended DAPT treatments.	dapt	171-175	cadherin 1	Homo sapiens	81-91
29515364-7	2018	We further demonstrated that the ability to regenerate HCs and the disruption of E-cadherin/p120ctn concomitantly decreased with age and ceased at P7, even after extended DAPT treatments.	dapt	171-175	catenin delta 1	Homo sapiens	92-99
29581976-5	2018	At the same time, Hypoxia can lead to EMT, and hypoxia-pretreated HIOECs increased fusion rate with OSCC, while the fusion rate was significantly reduced by DAPT, a kind of EMT blocker.	dapt	157-161	IL2 inducible T cell kinase	Homo sapiens	38-41
29487808-7	2018	The DAPT-treated rats displayed increased expression levels of Notch1, Bax, caspase-3, and GAP-43, decreased expression levels of Bcl-2, and increased RGC apoptosis, in comparison with the OH rats and PBS-injected rats.	dapt	4-8	notch receptor 1	Rattus norvegicus	63-69
29487808-7	2018	The DAPT-treated rats displayed increased expression levels of Notch1, Bax, caspase-3, and GAP-43, decreased expression levels of Bcl-2, and increased RGC apoptosis, in comparison with the OH rats and PBS-injected rats.	dapt	4-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	71-74
29487808-7	2018	The DAPT-treated rats displayed increased expression levels of Notch1, Bax, caspase-3, and GAP-43, decreased expression levels of Bcl-2, and increased RGC apoptosis, in comparison with the OH rats and PBS-injected rats.	dapt	4-8	caspase 3	Rattus norvegicus	76-85
29487808-7	2018	The DAPT-treated rats displayed increased expression levels of Notch1, Bax, caspase-3, and GAP-43, decreased expression levels of Bcl-2, and increased RGC apoptosis, in comparison with the OH rats and PBS-injected rats.	dapt	4-8	growth associated protein 43	Rattus norvegicus	91-97
29487808-7	2018	The DAPT-treated rats displayed increased expression levels of Notch1, Bax, caspase-3, and GAP-43, decreased expression levels of Bcl-2, and increased RGC apoptosis, in comparison with the OH rats and PBS-injected rats.	dapt	4-8	BCL2, apoptosis regulator	Rattus norvegicus	130-135
29636838-9	2018	DAPT also inhibited the stimulatory effect of polydatin on the Notch1/Hes1-Pten/Akt signaling pathway in a diabetic myocardium.	dapt	0-4	notch receptor 1	Rattus norvegicus	63-69
29636838-9	2018	DAPT also inhibited the stimulatory effect of polydatin on the Notch1/Hes1-Pten/Akt signaling pathway in a diabetic myocardium.	dapt	0-4	hes family bHLH transcription factor 1	Rattus norvegicus	70-74
29636838-9	2018	DAPT also inhibited the stimulatory effect of polydatin on the Notch1/Hes1-Pten/Akt signaling pathway in a diabetic myocardium.	dapt	0-4	phosphatase and tensin homolog	Rattus norvegicus	75-79
29636838-9	2018	DAPT also inhibited the stimulatory effect of polydatin on the Notch1/Hes1-Pten/Akt signaling pathway in a diabetic myocardium.	dapt	0-4	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
29447233-0	2018	Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.	dapt	26-30	notch receptor 1	Rattus norvegicus	0-5
29447233-2	2018	The gamma-secretase inhibitor DAPT inhibits Notch signaling pathway and promotes nerve regeneration after cerebral ischemia.	dapt	30-34	notch receptor 1	Rattus norvegicus	44-49
29447233-5	2018	After the administration of DAPT, the expression of Notch, Hes1 and Hes5 was inhibited, apoptosis and oxidative stress decreased, neurological function and cognitive function improved.	dapt	28-32	notch receptor 1	Rattus norvegicus	52-57
29447233-5	2018	After the administration of DAPT, the expression of Notch, Hes1 and Hes5 was inhibited, apoptosis and oxidative stress decreased, neurological function and cognitive function improved.	dapt	28-32	hes family bHLH transcription factor 1	Rattus norvegicus	59-63
29447233-5	2018	After the administration of DAPT, the expression of Notch, Hes1 and Hes5 was inhibited, apoptosis and oxidative stress decreased, neurological function and cognitive function improved.	dapt	28-32	hes family bHLH transcription factor 5	Rattus norvegicus	68-72
29447233-7	2018	Notch inhibitor DAPT can reduce oxidative stress and apoptosis after acute craniocerebral injury, and is a potential drug for the treatment of acute craniocerebral injury.	dapt	16-20	notch receptor 1	Rattus norvegicus	0-5
29581976-5	2018	At the same time, Hypoxia can lead to EMT, and hypoxia-pretreated HIOECs increased fusion rate with OSCC, while the fusion rate was significantly reduced by DAPT, a kind of EMT blocker.	dapt	157-161	IL2 inducible T cell kinase	Homo sapiens	173-176
29410396-5	2018	DAPT and shRNA targeting Notch1 decreased NF-kappaB(p65) expression, suppressed cell proliferation, and induced apoptosis of GBM cells in vitro and in vivo.	dapt	0-4	nuclear factor kappa B subunit 1	Homo sapiens	42-51
29410396-5	2018	DAPT and shRNA targeting Notch1 decreased NF-kappaB(p65) expression, suppressed cell proliferation, and induced apoptosis of GBM cells in vitro and in vivo.	dapt	0-4	RELA proto-oncogene, NF-kB subunit	Homo sapiens	52-55
28482141-7	2018	In the presence of DAPT and SAHM1, used as Notch pathway inhibitors, the expression of the osteogenic markers, including Runx2, Dlx5, Osterix, as well as Hes1 and Hes5 were significantly inhibited, both in unexposed and PEMF-exposed hMSCs.	dapt	19-23	notch receptor 4	Homo sapiens	43-48
29415754-1	2018	BACKGROUND: One-year dual antiplatelet therapy (DAPT), generally aspirin in combination with a P2Y12 receptor inhibitor, has been a standard treatment for patients undergoing percutaneous coronary intervention (PCI).	dapt	48-52	purinergic receptor P2Y12	Homo sapiens	95-100
29415754-3	2018	Thus, it is of great necessity to find an alternative drug that is as effective but safer and more economic than the P2Y12 inhibitors after termination of one-year DAPT.	dapt	164-168	purinergic receptor P2Y12	Homo sapiens	117-122
28482141-7	2018	In the presence of DAPT and SAHM1, used as Notch pathway inhibitors, the expression of the osteogenic markers, including Runx2, Dlx5, Osterix, as well as Hes1 and Hes5 were significantly inhibited, both in unexposed and PEMF-exposed hMSCs.	dapt	19-23	RUNX family transcription factor 2	Homo sapiens	121-126
28482141-7	2018	In the presence of DAPT and SAHM1, used as Notch pathway inhibitors, the expression of the osteogenic markers, including Runx2, Dlx5, Osterix, as well as Hes1 and Hes5 were significantly inhibited, both in unexposed and PEMF-exposed hMSCs.	dapt	19-23	distal-less homeobox 5	Homo sapiens	128-132
28482141-7	2018	In the presence of DAPT and SAHM1, used as Notch pathway inhibitors, the expression of the osteogenic markers, including Runx2, Dlx5, Osterix, as well as Hes1 and Hes5 were significantly inhibited, both in unexposed and PEMF-exposed hMSCs.	dapt	19-23	Sp7 transcription factor	Homo sapiens	134-141
28482141-7	2018	In the presence of DAPT and SAHM1, used as Notch pathway inhibitors, the expression of the osteogenic markers, including Runx2, Dlx5, Osterix, as well as Hes1 and Hes5 were significantly inhibited, both in unexposed and PEMF-exposed hMSCs.	dapt	19-23	hes family bHLH transcription factor 1	Homo sapiens	154-158
28482141-7	2018	In the presence of DAPT and SAHM1, used as Notch pathway inhibitors, the expression of the osteogenic markers, including Runx2, Dlx5, Osterix, as well as Hes1 and Hes5 were significantly inhibited, both in unexposed and PEMF-exposed hMSCs.	dapt	19-23	hes family bHLH transcription factor 5	Homo sapiens	163-167
29279531-3	2018	Here we evaluated the clinical outcomes of DAPT guided by CYP2C19 polymorphisms after implantation of second-generation drug-eluting stents (DESs) for ACS management.	dapt	43-47	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	58-65
29207144-13	2018	The indirect Notch inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester also affected the polarity and the formation of protrusions, and reduced the expression of DNER and glial fibrillary acidic protein in SGNs.	dapt	29-98	delta/notch-like EGF repeat containing	Mus musculus	190-194
29253571-6	2018	Our data suggest that Notch1/Hes1 signaling pathway is deactivated using DAPT with a low dose of Triton-X100 in this cancer cells.	dapt	73-77	notch receptor 1	Homo sapiens	22-28
29253571-6	2018	Our data suggest that Notch1/Hes1 signaling pathway is deactivated using DAPT with a low dose of Triton-X100 in this cancer cells.	dapt	73-77	hes family bHLH transcription factor 1	Homo sapiens	29-33
29345587-8	2018	DAPT may be replaced, not by TT, but by dual therapy comprising a NOAC with a P2Y12 inhibitor.	dapt	0-4	purinergic receptor P2Y12	Homo sapiens	78-83
28823624-9	2018	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the expression of Notch 1 and Hes 1 mRNA was down-regulated, augmentation of NICD and Hes 1 protein was ameliorated, the proliferation-inducing effect of Ost was abolished.	dapt	74-78	notch 1	Mus musculus	14-19
28823624-9	2018	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the expression of Notch 1 and Hes 1 mRNA was down-regulated, augmentation of NICD and Hes 1 protein was ameliorated, the proliferation-inducing effect of Ost was abolished.	dapt	74-78	notch 1	Mus musculus	98-105
28823624-9	2018	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the expression of Notch 1 and Hes 1 mRNA was down-regulated, augmentation of NICD and Hes 1 protein was ameliorated, the proliferation-inducing effect of Ost was abolished.	dapt	74-78	hes family bHLH transcription factor 1	Mus musculus	110-115
28823624-9	2018	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the expression of Notch 1 and Hes 1 mRNA was down-regulated, augmentation of NICD and Hes 1 protein was ameliorated, the proliferation-inducing effect of Ost was abolished.	dapt	74-78	hes family bHLH transcription factor 1	Mus musculus	166-171
30196281-11	2018	The expression of CK19, Sox9, and EpCAM was significantly increased in BA liver, while DAPT treatment decreased the expression of CK19, Sox9, and EpCAM.	dapt	87-91	keratin 19	Mus musculus	130-134
30196281-11	2018	The expression of CK19, Sox9, and EpCAM was significantly increased in BA liver, while DAPT treatment decreased the expression of CK19, Sox9, and EpCAM.	dapt	87-91	SRY (sex determining region Y)-box 9	Mus musculus	136-140
30196281-11	2018	The expression of CK19, Sox9, and EpCAM was significantly increased in BA liver, while DAPT treatment decreased the expression of CK19, Sox9, and EpCAM.	dapt	87-91	epithelial cell adhesion molecule	Mus musculus	146-151
29308737-2	2018	BACKGROUND: According to ACC/ AHA guidelines, a minimum of 1 year of dual anti- platelet therapy (DAPT) consisting of aspirin and a platelet ADP-receptor antagonist (P2Y12 inhibitor) is recommended for patients presenting acute coronary syndromes (ACS), regardless of which type of revascularization is performed during the acute event.	dapt	98-102	purinergic receptor P2Y12	Homo sapiens	132-153
29308737-2	2018	BACKGROUND: According to ACC/ AHA guidelines, a minimum of 1 year of dual anti- platelet therapy (DAPT) consisting of aspirin and a platelet ADP-receptor antagonist (P2Y12 inhibitor) is recommended for patients presenting acute coronary syndromes (ACS), regardless of which type of revascularization is performed during the acute event.	dapt	98-102	purinergic receptor P2Y12	Homo sapiens	166-171
29399073-7	2018	However, the Notch inhibitor DAPT almost abolished the protective effects of RLX.	dapt	29-33	notch receptor 1	Rattus norvegicus	13-18
29035086-6	2017	DAPT showed significant (*p < 0.05) downregulated expression of the NSC markers-Nestin and SOX2-at different time points (6 hours, 12 hours, 24 hours, 36 hours, and 5 days) post-treatment.	dapt	0-4	SRY-box transcription factor 2	Homo sapiens	94-98
29091481-1	2018	INTRODUCTION: Despite the undeniable benefits on reducing ischemic adverse events, antiplatelet regimens including dual antiplatelet therapy (DAPT) with aspirin and P2Y12 receptor inhibitors are associated with an increased risk of bleeding.	dapt	142-146	purinergic receptor P2Y12	Homo sapiens	165-170
29100034-8	2018	Our results showed that DAPT effectively inhibited the protein level of Hes1.	dapt	24-28	hes family bHLH transcription factor 1	Homo sapiens	72-76
29100034-10	2018	However, Th2 cells ratio decreased after blocking the Notch signaling pathway by DAPT and the Th2/Th1 ratio in TB patients were DAPT dose-dependent, accompanied by the decrease of IL-4 and GATA3.	dapt	128-132	negative elongation factor complex member C/D	Homo sapiens	98-101
29100034-10	2018	However, Th2 cells ratio decreased after blocking the Notch signaling pathway by DAPT and the Th2/Th1 ratio in TB patients were DAPT dose-dependent, accompanied by the decrease of IL-4 and GATA3.	dapt	128-132	interleukin 4	Homo sapiens	180-184
29100034-10	2018	However, Th2 cells ratio decreased after blocking the Notch signaling pathway by DAPT and the Th2/Th1 ratio in TB patients were DAPT dose-dependent, accompanied by the decrease of IL-4 and GATA3.	dapt	128-132	GATA binding protein 3	Homo sapiens	189-194
29100034-12	2018	In conclusion, our results suggest that blocking Notch signaling by DAPT could inhibit Th2 responses and restore Th1/Th2 imbalance in TB patients.	dapt	68-72	negative elongation factor complex member C/D	Homo sapiens	113-116
29035834-0	2017	Synergistic effect of mild hypothermia and the Notch inhibitor DAPT against post stroke seizures.	dapt	63-67	notch receptor 1	Rattus norvegicus	47-52
29035834-10	2017	DAPT was injected into the hippocampus of the rats to inhibit local Notch signaling.	dapt	0-4	notch receptor 1	Rattus norvegicus	68-73
29035834-14	2017	DAPT treatment normalized the homeostasis of excitatory and inhibitory synaptic neurotransmission, suggesting that aberrant activation of Notch signaling is involved in post-stroke seizures.	dapt	0-4	notch receptor 1	Rattus norvegicus	138-143
29035086-9	2017	The expression of Notch target genes in NSC cultures (Notch intracellular domain [NICD], HES1, and HES5) was also significantly downregulated after DAPT treatment.	dapt	148-152	hes family bHLH transcription factor 1	Homo sapiens	89-93
29035086-9	2017	The expression of Notch target genes in NSC cultures (Notch intracellular domain [NICD], HES1, and HES5) was also significantly downregulated after DAPT treatment.	dapt	148-152	hes family bHLH transcription factor 5	Homo sapiens	99-103
29035086-10	2017	In the presence of DAPT, the markers for neuronal (MAP2, NEFH); and glial (GFAP, GLUL, and MBP) lineages were significantly downregulated as seen via immunofluorescence and quantitative polymerase chain reaction, indicating the role of Notch in the tri-differentiation mechanism of NSCs as well.	dapt	19-23	microtubule associated protein 2	Homo sapiens	51-55
29035086-10	2017	In the presence of DAPT, the markers for neuronal (MAP2, NEFH); and glial (GFAP, GLUL, and MBP) lineages were significantly downregulated as seen via immunofluorescence and quantitative polymerase chain reaction, indicating the role of Notch in the tri-differentiation mechanism of NSCs as well.	dapt	19-23	neurofilament heavy chain	Homo sapiens	57-61
29035086-10	2017	In the presence of DAPT, the markers for neuronal (MAP2, NEFH); and glial (GFAP, GLUL, and MBP) lineages were significantly downregulated as seen via immunofluorescence and quantitative polymerase chain reaction, indicating the role of Notch in the tri-differentiation mechanism of NSCs as well.	dapt	19-23	glial fibrillary acidic protein	Homo sapiens	75-79
29035086-10	2017	In the presence of DAPT, the markers for neuronal (MAP2, NEFH); and glial (GFAP, GLUL, and MBP) lineages were significantly downregulated as seen via immunofluorescence and quantitative polymerase chain reaction, indicating the role of Notch in the tri-differentiation mechanism of NSCs as well.	dapt	19-23	glutamate-ammonia ligase	Homo sapiens	81-85
29035086-10	2017	In the presence of DAPT, the markers for neuronal (MAP2, NEFH); and glial (GFAP, GLUL, and MBP) lineages were significantly downregulated as seen via immunofluorescence and quantitative polymerase chain reaction, indicating the role of Notch in the tri-differentiation mechanism of NSCs as well.	dapt	19-23	myelin basic protein	Homo sapiens	91-94
28771710-11	2017	We demonstrate that the gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester blocks endothelia-induced increases in GLT-1.	dapt	50-119	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	159-164
29335059-2	2017	The aim of this study was to investigate the effect of ADRA2A variants on platelet reactivity in Chinese patients on dual antiplatelet therapy (DAPT) after undergoing percutaneous coronary intervention (PCI).	dapt	144-148	adrenoceptor alpha 2A	Homo sapiens	55-61
29335059-11	2017	CONCLUSION: ADRA2A genetic variations were associated with ADP-induced platelet aggregation during DAPT in Chinese patients undergoing PCI, and the effect was particularly more pronounced in males.	dapt	99-103	adrenoceptor alpha 2A	Homo sapiens	12-18
29204262-1	2017	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor antagonist represents the current standard of care to prevent atherothrombotic recurrences in patients with acute coronary syndrome (ACS).	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
29323051-0	2017	Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochleae.	dapt	24-28	atonal bHLH transcription factor 1	Rattus norvegicus	38-43
29323051-6	2017	Combined application of the Notch inhibitor DAPT and Atoh1 increased the Atoh1 expression level and decreased hes1 and hes5 levels, further promoting hair cell generation.	dapt	44-48	atonal bHLH transcription factor 1	Rattus norvegicus	73-78
29323051-6	2017	Combined application of the Notch inhibitor DAPT and Atoh1 increased the Atoh1 expression level and decreased hes1 and hes5 levels, further promoting hair cell generation.	dapt	44-48	hes family bHLH transcription factor 1	Rattus norvegicus	110-114
29323051-6	2017	Combined application of the Notch inhibitor DAPT and Atoh1 increased the Atoh1 expression level and decreased hes1 and hes5 levels, further promoting hair cell generation.	dapt	44-48	hes family bHLH transcription factor 5	Rattus norvegicus	119-123
29323051-7	2017	Our results demonstrate that DAPT enhances Atoh1 activity to promote hair cell regeneration in rat cochlear sensory epithelium in vitro.	dapt	29-33	atonal bHLH transcription factor 1	Rattus norvegicus	43-48
29344233-10	2017	Downregulation of the Notch signaling pathway by LDM was enhanced through combination with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester.	dapt	91-160	notch receptor 1	Homo sapiens	22-27
28601732-9	2017	The intermittent stress-induced Hes1 and Hey1 mRNA expression could be inhibited by a gamma-secretase inhibitor (DAPT) or a TGF-beta superfamily type I activing receptor-like kinase receptors inhibitor (SB431542).	dapt	113-117	hes family bHLH transcription factor 1	Mus musculus	32-36
29312637-3	2017	Our results show that activated Notch signaling results in down-regulation of Runx2 and early osteogenesis differentiation factors, without affecting p-Smad1/5/8 expression, and that blocking Notch signaling with DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) significantly increases p-Smad1/5/8 expression.	dapt	219-288	runt related transcription factor 2	Mus musculus	78-83
29312637-3	2017	Our results show that activated Notch signaling results in down-regulation of Runx2 and early osteogenesis differentiation factors, without affecting p-Smad1/5/8 expression, and that blocking Notch signaling with DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) significantly increases p-Smad1/5/8 expression.	dapt	219-288	SMAD family member 1	Mus musculus	316-323
28510646-3	2017	The objective of the present study was to evaluate the benefit of switching dual antiplatelet therapy (DAPT) from aspirin plus a newer P2Y12 blocker to aspirin plus clopidogrel 1 month after ACS.	dapt	103-107	purinergic receptor P2Y12	Homo sapiens	135-140
29049420-5	2017	Here we show that blocking of Notch-1 with N-[(3,5-Difluorophenyl) acetyl]-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester (DAPT) in LPS activated BV-2 microglia not only suppressed Notch intracellular domain (NICD) and Hes-1 protein expression, but also that of GSK-3beta.	dapt	125-129	notch receptor 1	Homo sapiens	30-37
29049420-5	2017	Here we show that blocking of Notch-1 with N-[(3,5-Difluorophenyl) acetyl]-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester (DAPT) in LPS activated BV-2 microglia not only suppressed Notch intracellular domain (NICD) and Hes-1 protein expression, but also that of GSK-3beta.	dapt	125-129	hes family bHLH transcription factor 1	Homo sapiens	221-226
29049420-5	2017	Here we show that blocking of Notch-1 with N-[(3,5-Difluorophenyl) acetyl]-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester (DAPT) in LPS activated BV-2 microglia not only suppressed Notch intracellular domain (NICD) and Hes-1 protein expression, but also that of GSK-3beta.	dapt	125-129	glycogen synthase kinase 3 beta	Homo sapiens	264-273
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	interleukin 1 beta	Homo sapiens	51-59
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	tumor necrosis factor	Homo sapiens	61-70
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	interleukin 6	Homo sapiens	72-76
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	nitric oxide synthase 2	Homo sapiens	78-82
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-88
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	C-C motif chemokine ligand 2	Homo sapiens	93-98
29049420-8	2017	Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells.	dapt	13-17	interleukin 10	Homo sapiens	109-114
29049420-10	2017	Additionally, NF-kappaB/p65 immunofluorescence was attenuated by DAPT and LiCl; as opposed to this, IkappaBalpha protein expression was increased.	dapt	65-69	RELA proto-oncogene, NF-kB subunit	Homo sapiens	24-27
29049420-10	2017	Additionally, NF-kappaB/p65 immunofluorescence was attenuated by DAPT and LiCl; as opposed to this, IkappaBalpha protein expression was increased.	dapt	65-69	NFKB inhibitor alpha	Homo sapiens	100-112
29123981-8	2017	Expression of cyclin D1, PDGFR, Notch1, and Hes1 was markedly enhanced by PDGF-BB but inhibited by DAPT.	dapt	99-103	cyclin D1	Homo sapiens	14-23
29123981-8	2017	Expression of cyclin D1, PDGFR, Notch1, and Hes1 was markedly enhanced by PDGF-BB but inhibited by DAPT.	dapt	99-103	platelet derived growth factor receptor beta	Homo sapiens	25-30
29123981-8	2017	Expression of cyclin D1, PDGFR, Notch1, and Hes1 was markedly enhanced by PDGF-BB but inhibited by DAPT.	dapt	99-103	notch receptor 1	Homo sapiens	32-38
29123981-8	2017	Expression of cyclin D1, PDGFR, Notch1, and Hes1 was markedly enhanced by PDGF-BB but inhibited by DAPT.	dapt	99-103	hes family bHLH transcription factor 1	Homo sapiens	44-48
29123981-10	2017	PDGF-BB increased the expression of kinase insert domain receptor (KDR, an endothelial marker) and activated Notch1 signaling in cocultured cells, while DAPT attenuated the promoting effect of PDGF-BB on KDR expression of hEPCs/hMSCs coculture.	dapt	153-157	kinase insert domain receptor	Homo sapiens	204-207
28601732-9	2017	The intermittent stress-induced Hes1 and Hey1 mRNA expression could be inhibited by a gamma-secretase inhibitor (DAPT) or a TGF-beta superfamily type I activing receptor-like kinase receptors inhibitor (SB431542).	dapt	113-117	hairy/enhancer-of-split related with YRPW motif 1	Mus musculus	41-45
28601732-11	2017	Further, the intermittent compressive stress reduced Sost mRNA expression and this phenomenon could be rescued by a DAPT pretreatment, implying the involvement of Notch signaling.	dapt	116-120	sclerostin	Mus musculus	53-57
28856557-5	2017	Also, observed mediation of ECs in regulation of tumor cell stemness by Notch activation was observed when the co-cultures were treated with gamma-secretase inhibitor (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT)).	dapt	168-237	Notch	Drosophila melanogaster	72-77
28772216-7	2017	Combination of DAPT and minocycline further inhibited Notch-1 receptor signaling and reduce neuropathic pain exhibited as improved TWL and MWT.	dapt	15-19	notch receptor 1	Rattus norvegicus	54-61
28772216-8	2017	Our study revealed a novel mechanism of Notch-1 receptor inhibition in spinal cord induced by minocycline administration, and suggested that the combination of minocycline and DAPT has the potential to treat DNP.	dapt	176-180	notch receptor 1	Rattus norvegicus	40-47
28856557-5	2017	Also, observed mediation of ECs in regulation of tumor cell stemness by Notch activation was observed when the co-cultures were treated with gamma-secretase inhibitor (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT)).	dapt	239-243	Notch	Drosophila melanogaster	72-77
28959004-8	2017	Furthermore, after blocking the Notch pathway by using DAPT, Jagged1 expression and EP proliferation, migration, and secretion of NO and VEGF were decreased in a dose-dependent manner.	dapt	55-59	jagged canonical Notch ligand 1	Homo sapiens	61-68
28849053-2	2017	N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester (DAPT) efficiently inhibits activation of the Notch 1 signaling pathway in microglia and may protect brain tissue from ischemic damage.	dapt	70-74	notch receptor 1	Rattus norvegicus	115-122
28849053-10	2017	The present study confirmed the protective effect of DAPT treatment by dynamically monitoring the cerebral alterations and indicated the possibility of DAPT treatment to alter microglial characteristics to induce a protective effect, via inhibition of the Notch signaling pathway.	dapt	53-57	notch receptor 1	Rattus norvegicus	256-261
28849053-10	2017	The present study confirmed the protective effect of DAPT treatment by dynamically monitoring the cerebral alterations and indicated the possibility of DAPT treatment to alter microglial characteristics to induce a protective effect, via inhibition of the Notch signaling pathway.	dapt	152-156	notch receptor 1	Rattus norvegicus	256-261
29169413-3	2017	Prior to stimulation with LPS, mouse RAW264.7 cells were treated with DAPT (10 mumol/L), an inhibitor of Notch1 signaling, for 1 hour.	dapt	70-74	notch 1	Mus musculus	105-111
29169413-8	2017	The levels of TNF-alpha, IL-1beta, IL-6, NO and PGE2 were significantly up-regulated in cell culture media after stimulated with LPS, but the levels of those inflammatory mediators were reduced by DAPT.	dapt	197-201	tumor necrosis factor	Mus musculus	14-23
29169413-8	2017	The levels of TNF-alpha, IL-1beta, IL-6, NO and PGE2 were significantly up-regulated in cell culture media after stimulated with LPS, but the levels of those inflammatory mediators were reduced by DAPT.	dapt	197-201	interleukin 1 beta	Mus musculus	25-33
29169413-8	2017	The levels of TNF-alpha, IL-1beta, IL-6, NO and PGE2 were significantly up-regulated in cell culture media after stimulated with LPS, but the levels of those inflammatory mediators were reduced by DAPT.	dapt	197-201	interleukin 6	Mus musculus	35-39
29169413-9	2017	The mRNA and protein levels of iNOS and COX-2 were significant raised in mouse RAW264.7 cells after stimulated with LPS, while they were inhibited by DAPT.	dapt	150-154	nitric oxide synthase 2, inducible	Mus musculus	31-35
29169413-9	2017	The mRNA and protein levels of iNOS and COX-2 were significant raised in mouse RAW264.7 cells after stimulated with LPS, while they were inhibited by DAPT.	dapt	150-154	prostaglandin-endoperoxide synthase 2	Mus musculus	40-45
29169413-10	2017	Both IkappaBalpha-phosphorylation and NF-kappaBp65 translocation into nuclear in LPS-induced RAW264.7 cells were also inhibited by DAPT.	dapt	131-135	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	5-17
28959004-8	2017	Furthermore, after blocking the Notch pathway by using DAPT, Jagged1 expression and EP proliferation, migration, and secretion of NO and VEGF were decreased in a dose-dependent manner.	dapt	55-59	vascular endothelial growth factor A	Homo sapiens	137-141
27808485-2	2017	EVIDENCE ACQUISITION: DAPT combining aspirin and oral P2Y12 receptor inhibitors increases the risk of gastrointestinal (GI) bleeding, with higher rates of morbidity and mortality in patients undergoing percutaneous coronary intervention (PCI).	dapt	22-26	purinergic receptor P2Y12	Homo sapiens	54-59
28859795-0	2017	Meta-Analyses on DAPT Length: Chasing the Calm After the (Perfect) Storm.	dapt	17-21	synaptosome associated protein 91	Homo sapiens	42-46
28859797-0	2017	Reply: Meta-Analyses on DAPT Length: Chasing the Calm After the (Perfect) Storm.	dapt	24-28	synaptosome associated protein 91	Homo sapiens	49-53
27878968-7	2017	Furthermore, CMK effect on ciliated cell differentiation was reversed by a Notch inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	91-160	notch receptor 1	Homo sapiens	75-80
28612281-6	2017	In patients with an acute coronary syndrome receiving dual antiplatelet therapy (DAPT), most centres discontinued the P2Y12 inhibitor preoperatively.	dapt	81-85	purinergic receptor P2Y12	Homo sapiens	118-123
28381584-1	2017	OBJECTIVES: Dual antiplatelet therapy (DAPT) with aspirin + a P2Y12 inhibitor is recommended for at least 12 months for patients with acute coronary syndrome (ACS), with shorter durations considered for patients with increased bleeding risk.	dapt	39-43	purinergic receptor P2Y12	Homo sapiens	62-67
28433569-5	2017	METHODS: Patients treated with DAPT (ASA and clopidogrel or ticagrelor) for an ACS or elective PCI were scheduled for platelet function assessment at 30-90days post-discharge.	dapt	31-35	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	79-82
28947978-5	2017	Furthermore, inhibition of NOTCH signal pathway in SW480 which has abundant NICD1 expression, was performed by transfection of siNICD1 or DAPT, gamma secretase inhibitor, treatment.	dapt	138-142	notch receptor 1	Homo sapiens	27-32
28583585-7	2017	The results suggested that expression of myelin basic protein (MBP) increased in P12 mice subjected to hyperoxia after DAPT pretreatment.	dapt	119-123	myelin basic protein	Mus musculus	41-61
28583585-7	2017	The results suggested that expression of myelin basic protein (MBP) increased in P12 mice subjected to hyperoxia after DAPT pretreatment.	dapt	119-123	myelin basic protein	Mus musculus	63-66
28583585-8	2017	Moreover, hyperoxia could cause mature oligodendrocytes (MBP+) counts decreased with an obvious inverse increase in OPCs (NG2+) after hyperoxia on P12, DAPT pretreatment significantly ameliorated disruption of oligodendrocytes maturation induced by hyperoxia.	dapt	152-156	myelin basic protein	Mus musculus	57-60
28526405-4	2017	Importantly, these changes in expression are significantly suppressed by the NOTCH1 inhibitor DAPT.	dapt	94-98	notch receptor 1	Homo sapiens	77-83
27853822-6	2017	Either reducing levels of Abeta with the gamma secretase inhibitor DAPT or blocking the membrane calcium channel formed by Abeta with tromethamine decreased cell stiffness to a level close to the control SH-SY5Y cells.	dapt	67-71	amyloid beta precursor protein	Homo sapiens	26-31
28158917-7	2017	Further, to better understand the relationship between Notch signalling and autophagy in podocyte differentiation, rapamycin was added to enhance autophagy levels in DAPT-treated cells, and as a result, nephrin was recovered and DAPT-induced injury was ameliorated.	dapt	166-170	notch 1	Mus musculus	55-60
28158917-7	2017	Further, to better understand the relationship between Notch signalling and autophagy in podocyte differentiation, rapamycin was added to enhance autophagy levels in DAPT-treated cells, and as a result, nephrin was recovered and DAPT-induced injury was ameliorated.	dapt	166-170	nephrosis 1, nephrin	Mus musculus	203-210
27878968-7	2017	Furthermore, CMK effect on ciliated cell differentiation was reversed by a Notch inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	162-166	notch receptor 1	Homo sapiens	75-80
28927121-10	2017	The levels of Jagged1, Notch1, VEGF protein and the interaction between Jagged1 and Notch1 in the DAPT inhibitor control group and drug serum group were significantly lower than in the control serum group (P<0.01).	dapt	98-102	jagged canonical Notch ligand 1	Homo sapiens	72-79
28927121-10	2017	The levels of Jagged1, Notch1, VEGF protein and the interaction between Jagged1 and Notch1 in the DAPT inhibitor control group and drug serum group were significantly lower than in the control serum group (P<0.01).	dapt	98-102	notch receptor 1	Homo sapiens	84-90
27595504-6	2017	RESULTS: DAPT reduced the nuclear expression of Notch and c-Myc and repressed cell growth, EMT-dependent cell invasion in vitro, and tumorigenicity in vivo.	dapt	9-13	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	58-63
27595504-6	2017	RESULTS: DAPT reduced the nuclear expression of Notch and c-Myc and repressed cell growth, EMT-dependent cell invasion in vitro, and tumorigenicity in vivo.	dapt	9-13	IL2 inducible T cell kinase	Homo sapiens	91-94
27966788-7	2017	DAPT pretreatment markedly reduced the intermittent stress-induced SOST expression.	dapt	0-4	sclerostin	Homo sapiens	67-71
27966788-10	2017	Further, DAPT treatment attenuated rhTGF-beta1-induced SOST expression.	dapt	9-13	sclerostin	Homo sapiens	55-59
28583499-2	2017	METHOD: GSI, N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butylester (DAPT) was administered to ovalbumin-induced AR mice models intranasally.	dapt	83-87	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	109-118
28583499-7	2017	RESULTS: The results showed that the DAPT ameliorated the development of AR and suppressed Th2 cytokine levels significantly, alleviating eosinophils infiltration and goblet cells metaplasia, suggesting that the GSI can regulate Th2 response and weaken airway inflammation in AR.	dapt	37-41	heart and neural crest derivatives expressed 2	Mus musculus	91-94
28583499-7	2017	RESULTS: The results showed that the DAPT ameliorated the development of AR and suppressed Th2 cytokine levels significantly, alleviating eosinophils infiltration and goblet cells metaplasia, suggesting that the GSI can regulate Th2 response and weaken airway inflammation in AR.	dapt	37-41	heart and neural crest derivatives expressed 2	Mus musculus	229-232
28286920-8	2017	However, TLR4 KO mice that received DAPT reduced APAP-induced liver damage and NF-kappaB, NLRP3, and cleaved caspase-1 activation.	dapt	36-40	toll-like receptor 4	Mus musculus	9-13
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	notch 1	Mus musculus	71-76
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	glutamic pyruvic transaminase, soluble	Mus musculus	164-167
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	hes family bHLH transcription factor 1	Homo sapiens	56-60
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	62-65
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	BCL2 associated X, apoptosis regulator	Homo sapiens	67-70
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	BCL2 apoptosis regulator	Homo sapiens	72-76
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	81-88
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	cyclin D2	Homo sapiens	176-181
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	cyclin dependent kinase inhibitor 1A	Homo sapiens	183-189
28400072-8	2017	Compared with the control group, the mRNA abundances of HES1, MYC, BAX, BCL2 and CYP19A1 in DAPT-treated groups was lower (P<0.05), respectively; whereas, the expression of CCND2, CDKN1A and TP53 mRNA showed no remarkable difference compared with control group.	dapt	92-96	tumor protein p53	Homo sapiens	194-198
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	hes family bHLH transcription factor 1	Mus musculus	187-216
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	hes family bHLH transcription factor 1	Mus musculus	218-222
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	signal transducer and activator of transcription 3	Mus musculus	244-249
28286920-8	2017	However, TLR4 KO mice that received DAPT reduced APAP-induced liver damage and NF-kappaB, NLRP3, and cleaved caspase-1 activation.	dapt	36-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
28286920-8	2017	However, TLR4 KO mice that received DAPT reduced APAP-induced liver damage and NF-kappaB, NLRP3, and cleaved caspase-1 activation.	dapt	36-40	NLR family, pyrin domain containing 3	Mus musculus	90-95
28605808-13	2017	Notch inhibition by DAPT also decreased Ki67 expression in LECs to the level of LNCs" effects.	dapt	20-24	notch receptor 1	Rattus norvegicus	0-5
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	thymoma viral proto-oncogene 1	Mus musculus	254-257
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	high mobility group box 1	Mus musculus	271-296
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	high mobility group box 1	Mus musculus	298-303
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	toll-like receptor 4	Mus musculus	306-310
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	312-321
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	NLR family, pyrin domain containing 3	Mus musculus	327-332
28498402-8	2017	RUNX3 expression was reduced in si-RUNX3 and si-RUNX3+DAPT group but the expression levels of Notch signaling related genes were markedly increased in si-RUNX3 group or decreased in DAPT and si-NC+DAPT group, as compared with those in the control group (all P<0.05).	dapt	54-58	RUNX family transcription factor 3	Homo sapiens	0-5
28498402-8	2017	RUNX3 expression was reduced in si-RUNX3 and si-RUNX3+DAPT group but the expression levels of Notch signaling related genes were markedly increased in si-RUNX3 group or decreased in DAPT and si-NC+DAPT group, as compared with those in the control group (all P<0.05).	dapt	182-186	notch receptor 1	Homo sapiens	94-99
28498402-8	2017	RUNX3 expression was reduced in si-RUNX3 and si-RUNX3+DAPT group but the expression levels of Notch signaling related genes were markedly increased in si-RUNX3 group or decreased in DAPT and si-NC+DAPT group, as compared with those in the control group (all P<0.05).	dapt	182-186	notch receptor 1	Homo sapiens	94-99
28262344-1	2017	BACKGROUND: The beneficial use of dual antiplatelet therapy (DAPT) with acetylsalicylic acid (ASA) and P2Y12 oinhibitors has been established for patients after acute coronary syndrome (ACS).	dapt	61-65	purinergic receptor P2Y12	Homo sapiens	103-108
28487945-3	2017	Nox4 and the Notch pathway were inhibited by N-acetylcysteine (NAC), diphenylene iodonium (DPI) or gamma-secretase inhibitor (DAPT).	dapt	126-130	NADPH oxidase 4	Homo sapiens	0-4
28487945-3	2017	Nox4 and the Notch pathway were inhibited by N-acetylcysteine (NAC), diphenylene iodonium (DPI) or gamma-secretase inhibitor (DAPT).	dapt	126-130	notch receptor 1	Homo sapiens	13-18
28487945-9	2017	Inhibition of the Notch pathway via DAPT increased Bcl-2 expression, decreased Bax and cleaved caspase-3 levels and prevented HKC cell apoptosis.	dapt	36-40	notch receptor 1	Homo sapiens	18-23
28487945-9	2017	Inhibition of the Notch pathway via DAPT increased Bcl-2 expression, decreased Bax and cleaved caspase-3 levels and prevented HKC cell apoptosis.	dapt	36-40	BCL2 apoptosis regulator	Homo sapiens	51-56
28487945-9	2017	Inhibition of the Notch pathway via DAPT increased Bcl-2 expression, decreased Bax and cleaved caspase-3 levels and prevented HKC cell apoptosis.	dapt	36-40	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
28411246-8	2017	CONCLUSIONS: GDF-15 at 1 month after an ACS is related to the risk of bleeding during DAPT and provides additional information on the bleeding risk beyond baseline GDF-15 levels.	dapt	86-90	growth differentiation factor 15	Homo sapiens	13-19
28163178-9	2017	Compared with PE groups, overexpression of Jagged1 significantly promoted AEPC functions including proliferation, migration, the tube formation ability, and cell differentiation, these effects could be reasonably diminished by DAPT.	dapt	227-231	jagged canonical Notch ligand 1	Rattus norvegicus	43-50
28522881-6	2017	Furthermore, when the Notch signaling inhibitor DAPT was added to a primary culture of adult rat anterior pituitary cells, the proportion of SOX2-expressing cells within Notch2-positive cells was approximately 30% lower.	dapt	48-52	notch receptor 2	Rattus norvegicus	22-27
28522881-6	2017	Furthermore, when the Notch signaling inhibitor DAPT was added to a primary culture of adult rat anterior pituitary cells, the proportion of SOX2-expressing cells within Notch2-positive cells was approximately 30% lower.	dapt	48-52	SRY-box transcription factor 2	Rattus norvegicus	141-145
28522881-6	2017	Furthermore, when the Notch signaling inhibitor DAPT was added to a primary culture of adult rat anterior pituitary cells, the proportion of SOX2-expressing cells within Notch2-positive cells was approximately 30% lower.	dapt	48-52	notch receptor 2	Rattus norvegicus	170-176
28325638-1	2017	BACKGROUND: Dual antiplatelet therapy (DAPT), aspirin plus a P2Y12 inhibitor, is the standard antithrombotic treatment following acute coronary syndromes.	dapt	39-43	purinergic receptor P2Y12	Homo sapiens	61-66
28580186-6	2017	We demonstrate that inhibition of gamma-secretase through DAPT down-regulates RBPJ and Hes1, up-regulates Mash1 and results in an enhanced differentiation of BMSCs into GABAergic cells.	dapt	58-62	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	78-82
28580186-6	2017	We demonstrate that inhibition of gamma-secretase through DAPT down-regulates RBPJ and Hes1, up-regulates Mash1 and results in an enhanced differentiation of BMSCs into GABAergic cells.	dapt	58-62	hes family bHLH transcription factor 1	Homo sapiens	87-91
28580186-6	2017	We demonstrate that inhibition of gamma-secretase through DAPT down-regulates RBPJ and Hes1, up-regulates Mash1 and results in an enhanced differentiation of BMSCs into GABAergic cells.	dapt	58-62	achaete-scute family bHLH transcription factor 1	Homo sapiens	106-111
28157396-7	2017	DAPT treatment reduced Th17 response by downregulation of RORgammat expression and interleukin (IL)-17/IL-22 secretion.	dapt	0-4	interleukin 17A	Homo sapiens	83-102
28428712-6	2017	Administration of DAPT and TGF-beta inhibitor suppressed Notch and TGF-beta signal transducer in PBMCs of model rats.	dapt	18-22	notch receptor 1	Rattus norvegicus	57-62
28428712-6	2017	Administration of DAPT and TGF-beta inhibitor suppressed Notch and TGF-beta signal transducer in PBMCs of model rats.	dapt	18-22	transforming growth factor, beta 1	Rattus norvegicus	67-75
28157396-7	2017	DAPT treatment reduced Th17 response by downregulation of RORgammat expression and interleukin (IL)-17/IL-22 secretion.	dapt	0-4	interleukin 22	Homo sapiens	103-108
28112174-8	2017	Moreover, the protective effects conferred by TSG on SIR-treated H9c2 cardiomyoblasts were abolished by co-administration of DAPT (the Notch1 signaling inhibitor).	dapt	125-129	notch 1	Mus musculus	135-141
28232113-9	2017	Importantly, the Notch inhibitor DAPT downregulated Notch activation and further enhanced siNOR1-induced reduction of cell proliferation and migration in HepG2 and Hep3B cells, whereas DAPT reversed the effect of NOR1 overexpression on cell proliferation and migration.	dapt	33-37	organic solute carrier partner 1	Homo sapiens	92-96
28130038-7	2017	Furthermore, when pretreated with DAPT, a gamma-secretase inhibitor, the Notch1 signaling pathway was blocked in APL cells, followed by the reduction of ATPR-induced autophagy and differentiation.	dapt	34-38	notch receptor 1	Homo sapiens	73-79
28262548-2	2017	Here we show that DAPT, a classical Notch inhibitor, enhances the conversion of mouse fibroblasts into induced cardiac-like myocytes by the transcription factors GATA4, HAND2, MEF2C, and TBX5.	dapt	18-22	GATA binding protein 4	Mus musculus	162-167
28262548-2	2017	Here we show that DAPT, a classical Notch inhibitor, enhances the conversion of mouse fibroblasts into induced cardiac-like myocytes by the transcription factors GATA4, HAND2, MEF2C, and TBX5.	dapt	18-22	heart and neural crest derivatives expressed 2	Mus musculus	169-174
28262548-2	2017	Here we show that DAPT, a classical Notch inhibitor, enhances the conversion of mouse fibroblasts into induced cardiac-like myocytes by the transcription factors GATA4, HAND2, MEF2C, and TBX5.	dapt	18-22	myocyte enhancer factor 2C	Mus musculus	176-181
28262548-2	2017	Here we show that DAPT, a classical Notch inhibitor, enhances the conversion of mouse fibroblasts into induced cardiac-like myocytes by the transcription factors GATA4, HAND2, MEF2C, and TBX5.	dapt	18-22	T-box 5	Mus musculus	187-191
28262548-6	2017	Mechanistically, DAPT increases binding of the transcription factor MEF2C to the promoter regions of cardiac structural genes.	dapt	17-21	myocyte enhancer factor 2C	Mus musculus	68-73
28238274-3	2017	Monocytes were treated with Notch-1 inhibitors DAPT or siRNA.	dapt	47-51	notch receptor 1	Homo sapiens	28-35
28238274-7	2017	Comparatively, there was a significant increase in M2 macrophages, as demonstrated by an increase in CD206 and arginase-1 positive cells treated with DAPT or siRNA (p < 0.05).	dapt	150-154	mannose receptor C-type 1	Homo sapiens	101-106
28238274-7	2017	Comparatively, there was a significant increase in M2 macrophages, as demonstrated by an increase in CD206 and arginase-1 positive cells treated with DAPT or siRNA (p < 0.05).	dapt	150-154	arginase 1	Homo sapiens	111-121
28238274-9	2017	We conclude that blocking the Notch-1 pathway with DAPT or siRNA attenuates pro-inflammatory cytokines, enhances M2 macrophage differentiation, and increases anti-inflammatory cytokines in primary human monocytes.	dapt	51-55	notch receptor 1	Homo sapiens	30-37
28267471-2	2017	Guidelines recommend at least 6- to 12 months of dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor such as clopidogrel.	dapt	76-80	purinergic receptor P2Y12	Homo sapiens	101-106
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	delta like canonical Notch ligand 4	Homo sapiens	113-117
27886192-9	2017	L-NAME, a NO synthase inhibitor and DAPT, a gamma-secretase inhibitor, alleviated PA-induced decrease in IGF-1R protein.	dapt	36-40	insulin-like growth factor 1 receptor	Rattus norvegicus	105-111
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	47-51	cone-rod homeobox	Homo sapiens	162-165
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	47-51	orthodenticle homeobox 2	Homo sapiens	167-171
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	47-51	neuronal differentiation 1	Homo sapiens	176-183
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	47-51	hes family bHLH transcription factor 5	Homo sapiens	208-212
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	47-51	neurogenin 2	Homo sapiens	217-221
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	87-91	cone-rod homeobox	Homo sapiens	162-165
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	87-91	orthodenticle homeobox 2	Homo sapiens	167-171
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	87-91	neuronal differentiation 1	Homo sapiens	176-183
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	87-91	hes family bHLH transcription factor 5	Homo sapiens	208-212
28124402-5	2017	Finally, we treated the fluorescent cells with DAPT, a Notch inhibitor, and found that DAPT-enhanced retinal differentiation was associated with up-regulation of Crx, Otx2 and NeuroD1, and down-regulation of Hes5 and Ngn2.	dapt	87-91	neurogenin 2	Homo sapiens	217-221
28139517-12	2017	All these cellular and molecular effects induced by Ang II in the hearts of mice were reduced by DAPT treatment.	dapt	97-101	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	52-58
27426936-10	2017	The presence of MVD was associated with higher MACE rates in the short-term DAPT group in women (HR: 1.16; CI 0.60-2.23) and men (HR: 2.29; CI 1.22-4.29; P interaction = 0.25).	dapt	76-80	mevalonate diphosphate decarboxylase	Homo sapiens	16-19
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	notch receptor 1	Homo sapiens	119-125
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	notch receptor 1	Homo sapiens	135-141
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	hes family bHLH transcription factor 1	Homo sapiens	143-147
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	H3 histone pseudogene 16	Homo sapiens	153-156
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	delta like canonical Notch ligand 4	Homo sapiens	297-301
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	notch receptor 1	Homo sapiens	135-141
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	notch receptor 1	Homo sapiens	135-141
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	notch receptor 4	Homo sapiens	327-333
27939630-4	2017	The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan.	dapt	16-20	hes family bHLH transcription factor 1	Homo sapiens	339-343
28184261-1	2017	Dual antiplatelet therapy (DAPT) consisting of aspirin plus a P2Y12 inhibitor (clopidogrel, prasugrel, or ticagrelor) is imperative for the treatment of acute coronary syndrome, particularly during the re-endothelialization period after percutaneous coronary intervention (PCI).	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	62-67
27999190-8	2017	Leptin-induced effects on PC and tumorspheres were decreased by IONP-LPrA2 and DAPT.	dapt	79-83	leptin	Homo sapiens	0-6
27684192-7	2017	IkappaB-alpha and Hes-1 mRNA levels decreased to 5 or 3% and 6% or 2% after treatment with Bay 11-7085 or DAPT, respectively (p<0.05).	dapt	106-110	NFKB inhibitor alpha	Homo sapiens	0-13
27908834-3	2017	SKOV3 cells incubated in the presence of TGF-beta showed morphological and biochemical changes related to EMT, which were blocked by co-stimulation with TGF-beta and the gamma-secretase inhibitor DAPT.	dapt	196-200	transforming growth factor beta 1	Homo sapiens	41-49
27908834-5	2017	DAPT impaired the translocation of phospho-beta-catenin to the inner cell compartment observed in TGF-beta-treated cells, but was not able to block the induction at protein level induced by TGF-beta.	dapt	0-4	catenin beta 1	Homo sapiens	43-55
27908834-5	2017	DAPT impaired the translocation of phospho-beta-catenin to the inner cell compartment observed in TGF-beta-treated cells, but was not able to block the induction at protein level induced by TGF-beta.	dapt	0-4	transforming growth factor beta 1	Homo sapiens	98-106
27908834-7	2017	Notch target genes (Hes1 and Hey1) were induced by TGF-beta, decreased by DAPT treatment and remained low in the presence of both stimuli.	dapt	74-78	hes family bHLH transcription factor 1	Homo sapiens	20-24
27908834-7	2017	Notch target genes (Hes1 and Hey1) were induced by TGF-beta, decreased by DAPT treatment and remained low in the presence of both stimuli.	dapt	74-78	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	29-33
27840199-9	2017	Interestingly, the CS cell expansion that typifies tbx2a/b deficiency also occurred when blocking Notch signaling with the chemical DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).	dapt	132-136	T-box transcription factor 2a	Danio rerio	51-56
27840199-9	2017	Interestingly, the CS cell expansion that typifies tbx2a/b deficiency also occurred when blocking Notch signaling with the chemical DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).	dapt	138-207	T-box transcription factor 2a	Danio rerio	51-56
27840199-11	2017	To further examine the link between the tbx2a/b genes and Notch during CS formation, DAPT treatment was used to block Notch activity in tbx2a/b deficient embryos, and tbx2a/b knockdown was performed in NICD transgenic embryos.	dapt	85-89	T-box transcription factor 2a	Danio rerio	136-141
27840199-11	2017	To further examine the link between the tbx2a/b genes and Notch during CS formation, DAPT treatment was used to block Notch activity in tbx2a/b deficient embryos, and tbx2a/b knockdown was performed in NICD transgenic embryos.	dapt	85-89	T-box transcription factor 2a	Danio rerio	136-141
27684192-7	2017	IkappaB-alpha and Hes-1 mRNA levels decreased to 5 or 3% and 6% or 2% after treatment with Bay 11-7085 or DAPT, respectively (p<0.05).	dapt	106-110	hes family bHLH transcription factor 1	Homo sapiens	18-23
27925454-5	2016	However, the pretreatment of Rap1A-overexpressing cells with the Notch inhibitor DAPT or ERK inhibitor (U0126) inhibited the up-regulated expression of those molecules.	dapt	81-85	RAP1A, member of RAS oncogene family	Homo sapiens	29-34
27914492-2	2016	Antiplatelet monotherapy with a potent P2Y12 receptor antagonist may reduce bleeding while maintaining anti thrombotic efficacy compared with conventional DAPT.	dapt	155-159	purinergic receptor P2Y12	Homo sapiens	39-44
28904317-5	2017	In the presence of DAPT, a Notch signaling inhibitor, during osteogenic induction, mRNA levels for osteogenic marker genes were significantly decreased; however, no difference was noted in mineral deposition.	dapt	19-23	notch 1	Mus musculus	27-32
28058211-5	2016	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor such as clopidogrel, prasugrel and ticagrelor is instated post stenting to decrease the incident of ST. Cangrelor has recently been approved by Food and Drug Administration and can be used as a bridging antiplatelet drug.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
27959713-1	2016	BACKGROUND: In patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) with placement of stents, standard anticoagulation with a vitamin K antagonist plus dual antiplatelet therapy (DAPT) with a P2Y12 inhibitor and aspirin reduces the risk of thrombosis and stroke but increases the risk of bleeding.	dapt	212-216	purinergic receptor P2Y12	Homo sapiens	225-230
27821106-7	2016	Second, GSI IX, which is a gamma-secretase-inhibitor, was used for Notch signaling blockade in the following experiment.	dapt	8-14	notch receptor 1	Homo sapiens	67-72
27807176-7	2016	Last, Notch signaling inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) significantly rescued Tat-impaired NPC differentiation in vitro and neurogenesis in vivo Together, these results show that Tat adversely affects NPCs and neurogenesis through Notch signaling and point to the potential of developing Notch signaling inhibitors as HIV/neuroAIDS therapeutics.	dapt	32-101	tyrosine aminotransferase	Mus musculus	131-134
27807176-7	2016	Last, Notch signaling inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) significantly rescued Tat-impaired NPC differentiation in vitro and neurogenesis in vivo Together, these results show that Tat adversely affects NPCs and neurogenesis through Notch signaling and point to the potential of developing Notch signaling inhibitors as HIV/neuroAIDS therapeutics.	dapt	32-101	tyrosine aminotransferase	Mus musculus	232-235
27807176-7	2016	Last, Notch signaling inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) significantly rescued Tat-impaired NPC differentiation in vitro and neurogenesis in vivo Together, these results show that Tat adversely affects NPCs and neurogenesis through Notch signaling and point to the potential of developing Notch signaling inhibitors as HIV/neuroAIDS therapeutics.	dapt	103-107	tyrosine aminotransferase	Mus musculus	131-134
27807176-7	2016	Last, Notch signaling inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) significantly rescued Tat-impaired NPC differentiation in vitro and neurogenesis in vivo Together, these results show that Tat adversely affects NPCs and neurogenesis through Notch signaling and point to the potential of developing Notch signaling inhibitors as HIV/neuroAIDS therapeutics.	dapt	103-107	tyrosine aminotransferase	Mus musculus	232-235
27309035-1	2016	INTRODUCTION: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor represents the mainstay of pharmacotherapy in patients undergoing coronary stenting.	dapt	41-45	purinergic receptor P2Y12	Homo sapiens	66-71
27677287-9	2016	Compared to untreated control cells, DAPT dose dependently increased Numb expression and inhibited Notch1, Hes1, and Hes5 expressions at 2 Gy (P < 0.05).	dapt	37-41	NUMB endocytic adaptor protein	Homo sapiens	69-73
27677287-9	2016	Compared to untreated control cells, DAPT dose dependently increased Numb expression and inhibited Notch1, Hes1, and Hes5 expressions at 2 Gy (P < 0.05).	dapt	37-41	notch receptor 1	Homo sapiens	99-105
27677287-9	2016	Compared to untreated control cells, DAPT dose dependently increased Numb expression and inhibited Notch1, Hes1, and Hes5 expressions at 2 Gy (P < 0.05).	dapt	37-41	hes family bHLH transcription factor 1	Homo sapiens	107-111
27677287-9	2016	Compared to untreated control cells, DAPT dose dependently increased Numb expression and inhibited Notch1, Hes1, and Hes5 expressions at 2 Gy (P < 0.05).	dapt	37-41	hes family bHLH transcription factor 5	Homo sapiens	117-121
27698877-9	2016	DAPT/TRAIL apoptotic synergy was dependent on the extrinsic apoptotic pathway and was associated with a decrease in BH3 interacting-domain death agonist and x-linked inhibitor of apoptosis.	dapt	0-4	TNF superfamily member 10	Homo sapiens	5-10
27698877-9	2016	DAPT/TRAIL apoptotic synergy was dependent on the extrinsic apoptotic pathway and was associated with a decrease in BH3 interacting-domain death agonist and x-linked inhibitor of apoptosis.	dapt	0-4	X-linked inhibitor of apoptosis	Homo sapiens	157-188
26036783-5	2016	Inhibition of the proliferation of PAGCs by N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butylester (DAPT), an inhibitor of Notch signalling, was rescued by both the addition of ActA and overexpression of Smad3, indicating an interaction between the TGF-beta and Notch signalling pathways.	dapt	114-118	SMAD family member 3	Homo sapiens	218-223
26036783-5	2016	Inhibition of the proliferation of PAGCs by N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butylester (DAPT), an inhibitor of Notch signalling, was rescued by both the addition of ActA and overexpression of Smad3, indicating an interaction between the TGF-beta and Notch signalling pathways.	dapt	114-118	transforming growth factor beta 1	Homo sapiens	263-271
27630117-9	2016	In vitro studies were conducted to determine whether the melatonin-mediated protection against Abeta1-42 was inhibited by DAPT, an inhibitor of Notch signaling.	dapt	122-126	notch receptor 1	Rattus norvegicus	144-149
27570480-4	2016	We investigated the effects and underlying mechanisms of gamma-secretase inhibitor DAPT, a Notch signaling inhibitor on angiotensin II (Ang II)-induced proliferation and migration of DASMCs.	dapt	83-87	angiotensinogen	Homo sapiens	120-134
27643563-4	2016	We demonstrate density-dependent induction of EndMT that can be rescued by the Notch signaling inhibitor DAPT and identify a positive feedback signaling mechanism in hESC-ECs whereby trans-activation of Notch by DLL4 ligand induces elevated expression and surface presentation of DLL4.	dapt	105-109	delta like canonical Notch ligand 4	Homo sapiens	212-216
27075926-5	2016	Time course experiments demonstrate that inhibition of Notch by DAPT (a gamma-secretase inhibitor) decreases TGFbeta-induced phosphorylation of receptor Smads at late, but not at early, timepoints.	dapt	64-68	transforming growth factor beta 1	Homo sapiens	109-116
27075926-7	2016	Furthermore, inhibition of Notch by DAPT decreases TGFbeta induction of Slug and repression of E-cadherin and knockdown of Notch1 decreases TGFbeta-induced repression of E-cadherin, indicating that Notch is required, at least in part, for TGFbeta-induced EMT in EOC cells.	dapt	36-40	transforming growth factor beta 1	Homo sapiens	51-58
27075926-7	2016	Furthermore, inhibition of Notch by DAPT decreases TGFbeta induction of Slug and repression of E-cadherin and knockdown of Notch1 decreases TGFbeta-induced repression of E-cadherin, indicating that Notch is required, at least in part, for TGFbeta-induced EMT in EOC cells.	dapt	36-40	snail family transcriptional repressor 2	Homo sapiens	72-76
27075926-7	2016	Furthermore, inhibition of Notch by DAPT decreases TGFbeta induction of Slug and repression of E-cadherin and knockdown of Notch1 decreases TGFbeta-induced repression of E-cadherin, indicating that Notch is required, at least in part, for TGFbeta-induced EMT in EOC cells.	dapt	36-40	cadherin 1	Homo sapiens	95-105
27086085-4	2016	Therefore, the aim of the present study was to assess the impact of parathyroid hormone (PTH) on platelet reactivity in patients receiving DAPT after an acute coronary syndrome or PCI.	dapt	139-143	parathyroid hormone	Homo sapiens	68-87
27234159-7	2016	In these cells, Notch4 was also downregulated, both by Notch4 gene knockdown and by application of the gamma-secretase inhibitor, DAPT.	dapt	130-134	notch receptor 4	Homo sapiens	16-22
26681554-10	2016	In addition, treatment of LECs with ectopic expression of CtBP2 changed the expressions of CX43, alpha-SMA, Notch1, and NICD, but blockade of Notch pathway with DAPT inhibited CtBP2-induced changes of alpha-SMA and CX43.	dapt	161-165	C-terminal binding protein 2	Homo sapiens	58-63
26681554-10	2016	In addition, treatment of LECs with ectopic expression of CtBP2 changed the expressions of CX43, alpha-SMA, Notch1, and NICD, but blockade of Notch pathway with DAPT inhibited CtBP2-induced changes of alpha-SMA and CX43.	dapt	161-165	C-terminal binding protein 2	Homo sapiens	176-181
26681554-10	2016	In addition, treatment of LECs with ectopic expression of CtBP2 changed the expressions of CX43, alpha-SMA, Notch1, and NICD, but blockade of Notch pathway with DAPT inhibited CtBP2-induced changes of alpha-SMA and CX43.	dapt	161-165	gap junction protein alpha 1	Homo sapiens	215-219
27236738-1	2016	OBJECTIVE: Restenosis and stent thrombosis after endovascular intervention in patients with peripheral arterial disease (PAD) can potentially be tackled by more intensive antiplatelet therapy, such as dual antiplatelet therapy (DAPT) consisting of aspirin and P2Y12 inhibitor.	dapt	228-232	purinergic receptor P2Y12	Homo sapiens	260-265
27452835-9	2016	In addition, notch1a was up-regulated in CA-4 treated embryos, and inhibition of Notch signaling by DAPT partially rescued the apoptosis in zebrafish central nervous system caused by CA-4.	dapt	100-104	notch receptor 1a	Danio rerio	13-20
27570480-4	2016	We investigated the effects and underlying mechanisms of gamma-secretase inhibitor DAPT, a Notch signaling inhibitor on angiotensin II (Ang II)-induced proliferation and migration of DASMCs.	dapt	83-87	angiotensinogen	Homo sapiens	136-142
27570480-7	2016	We found that DAPT inhibited Ang II-induced DASMCs proliferation and migration dose dependently.	dapt	14-18	angiotensinogen	Homo sapiens	29-35
27570480-8	2016	DAPT also arrested the cell cycle progression in the G0/G1-phase, and attenuated calcium overload and ROS production caused by Ang II.	dapt	0-4	angiotensinogen	Homo sapiens	127-133
27570480-9	2016	Moreover, DAPT inhibited nuclear translocation of Notch3 receptor intracellular domain, with decreased expression of its down-stream genes including HES1, HES2 and HES5.	dapt	10-14	notch receptor 3	Homo sapiens	50-56
27570480-9	2016	Moreover, DAPT inhibited nuclear translocation of Notch3 receptor intracellular domain, with decreased expression of its down-stream genes including HES1, HES2 and HES5.	dapt	10-14	hes family bHLH transcription factor 1	Homo sapiens	149-153
27570480-9	2016	Moreover, DAPT inhibited nuclear translocation of Notch3 receptor intracellular domain, with decreased expression of its down-stream genes including HES1, HES2 and HES5.	dapt	10-14	hes family bHLH transcription factor 2	Homo sapiens	155-159
27570480-9	2016	Moreover, DAPT inhibited nuclear translocation of Notch3 receptor intracellular domain, with decreased expression of its down-stream genes including HES1, HES2 and HES5.	dapt	10-14	hes family bHLH transcription factor 5	Homo sapiens	164-168
27570480-10	2016	Finally, Ang II-activated ERK1/2, JNK and Akt were also counteracted by DAPT.	dapt	72-76	angiotensinogen	Homo sapiens	9-15
27570480-10	2016	Finally, Ang II-activated ERK1/2, JNK and Akt were also counteracted by DAPT.	dapt	72-76	mitogen-activated protein kinase 3	Homo sapiens	26-32
27570480-10	2016	Finally, Ang II-activated ERK1/2, JNK and Akt were also counteracted by DAPT.	dapt	72-76	mitogen-activated protein kinase 8	Homo sapiens	34-37
27570480-10	2016	Finally, Ang II-activated ERK1/2, JNK and Akt were also counteracted by DAPT.	dapt	72-76	AKT serine/threonine kinase 1	Homo sapiens	42-45
27570480-11	2016	In conclusion, DAPT inhibits Ang II-induced DASMCs proliferation and migration.	dapt	15-19	angiotensinogen	Homo sapiens	29-35
27102001-6	2016	DAPT, an inhibitor of the endogenous Notch pathway, was able to abrogate the miR-146a-induced increase of cytokines in MSC, suggesting the involvement of the Notch pathway.	dapt	0-4	microRNA 146a	Homo sapiens	77-85
27220406-4	2016	The results of western blot and reverse transcription-quantitative polymerase chain reaction analyses showed that the cobalt treatment increased the levels of activated beta-catenin protein and the expression levels of the target genes, axis inhibition protein 2 and myelocytomatosis oncogene, under DAPT-induced Notch repression.	dapt	300-304	catenin (cadherin associated protein), beta 1	Mus musculus	169-181
26899251-6	2016	The numbers of cysts, primordial follicles (PrFs) and primary follicles were unchanged by DES, whereas the total number of PrFs and of PrFs with Ki-67-negative cells was reduced by DAPT.	dapt	181-185	antigen identified by monoclonal antibody Ki 67	Mus musculus	145-150
27176495-3	2016	Noteworthy, blocking of Notch signaling with DAPT resulted in growth inhibition in ICN1-overexpressing CaSki and HT-3 cells.	dapt	45-49	notch receptor 1	Homo sapiens	24-29
27176495-8	2016	Notch signaling inhibitor DAPT partly reversed VPA-induced Snail1 upregulation in HeLa cells.	dapt	26-30	notch receptor 1	Homo sapiens	0-5
27176495-8	2016	Notch signaling inhibitor DAPT partly reversed VPA-induced Snail1 upregulation in HeLa cells.	dapt	26-30	snail family transcriptional repressor 1	Homo sapiens	59-65
27220406-4	2016	The results of western blot and reverse transcription-quantitative polymerase chain reaction analyses showed that the cobalt treatment increased the levels of activated beta-catenin protein and the expression levels of the target genes, axis inhibition protein 2 and myelocytomatosis oncogene, under DAPT-induced Notch repression.	dapt	300-304	axin 2	Mus musculus	237-262
27220406-6	2016	In a beta-catenin gene-knockdown experiment, the proliferation of the MC3T3-E1 cells under hypoxia were decreased by DAPT treatment, and knockdown of the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) suppressed the cobalt-induced increase in Wnt target gene levels.	dapt	117-121	catenin (cadherin associated protein), beta 1	Mus musculus	5-17
26894983-2	2016	Here, a novel electrochemical aptasensor was developed for ultrasensitive and selective detection of Mb, based on Y-shape structure of dual-aptamer (DApt)-complementary strand of aptamer (CS) conjugate, gold electrode and exonuclease I (Exo I).	dapt	149-153	myoglobin	Homo sapiens	101-103
27276686-6	2016	Mechanistically, ATG4A promotes gastric cancer cell stem-like properties and the EMT phenotype through the activation of Notch signaling not via autophagy, and using the Notch signaling inhibitor DAPT attenuated the effects of ATG4A on gastric cancer cells.	dapt	196-200	autophagy related 4A cysteine peptidase	Homo sapiens	227-232
26894983-6	2016	Upon addition of target, the DApt leave the CS and bind to Mb, leading to disassembly of Y-shape structure and following the addition of Exo I, a strong electrochemical signal could be recorded.	dapt	29-33	myoglobin	Homo sapiens	59-61
26772969-6	2016	We demonstrate that spine changes are completely reversed within few days after blocking amyloid-beta (Abeta) production with the gamma-secretase inhibitor DAPT.	dapt	156-160	amyloid beta (A4) precursor protein	Mus musculus	103-108
27264218-7	2016	CONCLUSION: Prolonged DAPT after MI reduces MACE and cardiovascular mortality over the long term; this was paralleled by higher risk of nonfatal major bleeding mainly with the newer, more potent P2Y12 antagonists.	dapt	22-26	purinergic receptor P2Y12	Homo sapiens	195-200
27146698-6	2016	In contrast, treatment of chondrocytes with the Notch inhibitor, DAPT, decreased both endogenous and BMP2-induced SMAD 1/5/8 phosphorylation and knockdown of SMAD 1/5/8 impaired NICD-induced chondrocyte differentiation and p57 expression.	dapt	65-69	bone morphogenetic protein 2	Mus musculus	101-105
27102300-9	2016	The Notch inhibitor DAPT also prevented tumor recurrence in resistant xenograft tumors.	dapt	20-24	notch receptor 1	Homo sapiens	4-9
26857211-7	2016	Overall, the PEGASUS-TIMI 54 results demonstrate that patients with a history of ACS deemed to be at high risk of further ischaemic events, particularly those in whom the risks of ischaemic events and cardiovascular death outweigh the risk of life-threatening bleeding, may benefit from prolonged ticagrelor-based DAPT.	dapt	314-318	IKAROS family zinc finger 5	Homo sapiens	13-28
27146698-6	2016	In contrast, treatment of chondrocytes with the Notch inhibitor, DAPT, decreased both endogenous and BMP2-induced SMAD 1/5/8 phosphorylation and knockdown of SMAD 1/5/8 impaired NICD-induced chondrocyte differentiation and p57 expression.	dapt	65-69	SMAD family member 1	Mus musculus	114-122
27146698-6	2016	In contrast, treatment of chondrocytes with the Notch inhibitor, DAPT, decreased both endogenous and BMP2-induced SMAD 1/5/8 phosphorylation and knockdown of SMAD 1/5/8 impaired NICD-induced chondrocyte differentiation and p57 expression.	dapt	65-69	SMAD family member 1	Mus musculus	158-166
27146698-6	2016	In contrast, treatment of chondrocytes with the Notch inhibitor, DAPT, decreased both endogenous and BMP2-induced SMAD 1/5/8 phosphorylation and knockdown of SMAD 1/5/8 impaired NICD-induced chondrocyte differentiation and p57 expression.	dapt	65-69	coronin, actin binding protein 1A	Mus musculus	223-226
27070866-9	2016	However, pretreatment with DAPT, a Notch1 inhibitor, effectively attenuated the cardioprotective effects of ASI against A/R injury, except MDA, SOD, GSH-Px, and the ROS generation.	dapt	27-31	notch receptor 1	Rattus norvegicus	35-41
27168786-9	2016	The inhibition of Notch by DAPT resulted in fewer EdU-positive cells and the upregulation of the expression levels of various mucous cell-associated genes.	dapt	27-31	notch 1	Mus musculus	18-23
25344626-4	2016	By 2 days postpartum, ovaries exposed to DAPT, short interference (si) RNA against Notch1 or siRNA against Hairy and enhancer of split-1 (Hes1) had significantly decreased expression of HES1, the target protein of the Notch signalling pathway.	dapt	41-45	hes family bHLH transcription factor 1	Mus musculus	186-190
27108536-4	2016	NOTCH1 inhibitor DAPT (GSI-IX) significantly reduces CSCs population and tumor self-renewal ability in vitro and in vivo.	dapt	17-21	notch receptor 1	Homo sapiens	0-6
27108536-4	2016	NOTCH1 inhibitor DAPT (GSI-IX) significantly reduces CSCs population and tumor self-renewal ability in vitro and in vivo.	dapt	23-29	notch receptor 1	Homo sapiens	0-6
27084744-9	2016	A gamma-secretase inhibitor, DAPT, selectively depleted CD133(+)cells, suppressed N1ICD and SKP2, induced p27Kip1, inhibited ACC growthin vivo, and sensitized CD133(+)cells to radiation.	dapt	29-33	S-phase kinase associated protein 2	Homo sapiens	92-96
27084744-9	2016	A gamma-secretase inhibitor, DAPT, selectively depleted CD133(+)cells, suppressed N1ICD and SKP2, induced p27Kip1, inhibited ACC growthin vivo, and sensitized CD133(+)cells to radiation.	dapt	29-33	cyclin dependent kinase inhibitor 1B	Homo sapiens	106-113
27118928-11	2016	Inhibition of EGFR and Notch signaling was achieved using either Iressa (gefitinib) or the gamma-secretase inhibitor DAPT.	dapt	117-121	epidermal growth factor receptor	Homo sapiens	14-18
26995378-1	2016	Dual antiplatelet therapy (DAPT), the combination of aspirin and a P2Y12 inhibitor, given for 12 months remains the standard of care after presentation with acute coronary syndrome (ACS) because it has been shown to be associated with a significant reduction in ischemic events compared with aspirin monotherapy.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	67-72
26827902-13	2016	Further, abrogation of Notch with the small molecule inhibitor DAPT increased the renal progenitor etv5a expression domain as well as MCC density in etv5a deficient embryos, suggesting Notch acts upstream to inhibit etv5a.	dapt	63-67	ETS variant transcription factor 5a	Danio rerio	99-104
26827902-13	2016	Further, abrogation of Notch with the small molecule inhibitor DAPT increased the renal progenitor etv5a expression domain as well as MCC density in etv5a deficient embryos, suggesting Notch acts upstream to inhibit etv5a.	dapt	63-67	ETS variant transcription factor 5a	Danio rerio	149-154
26827902-13	2016	Further, abrogation of Notch with the small molecule inhibitor DAPT increased the renal progenitor etv5a expression domain as well as MCC density in etv5a deficient embryos, suggesting Notch acts upstream to inhibit etv5a.	dapt	63-67	ETS variant transcription factor 5a	Danio rerio	149-154
26825631-4	2016	Here, we evaluated the transcription and expression patterns of Notch components (Notch1-3, Dll1, Dll4, and Jagged1) and effectors (Hes1-2 and Hes5) in the adult mouse epididymis, and evaluated the role of Notch signaling in the epididymis through its in vivo blockade following administration of an inhibitor (DAPT).	dapt	311-315	notch 1	Mus musculus	64-69
26607252-9	2016	Since we were able to show that both Lingo-1 shRNA and DAPT could drive neural stem/progenitor cells differentiation, our data might aid the development of more effective SCI therapies using Lingo-1 shRNA and DAPT.	dapt	55-59	leucine rich repeat and Ig domain containing 1	Homo sapiens	191-198
26607252-9	2016	Since we were able to show that both Lingo-1 shRNA and DAPT could drive neural stem/progenitor cells differentiation, our data might aid the development of more effective SCI therapies using Lingo-1 shRNA and DAPT.	dapt	209-213	leucine rich repeat and Ig domain containing 1	Homo sapiens	37-44
26607252-3	2016	While Lingo-1 shRNA and N-[N-(3, 5-difluorophenacetyl)-1-alanyl]-S-Phenylglycinet-butylester (DAPT), a Notch pathway inhibitor, have been used separately to help repair SCI, the results have been unsatisfactory.	dapt	94-98	leucine rich repeat and Ig domain containing 1	Homo sapiens	6-13
26607252-6	2016	The addition of DAPT decreased the expression of Notch intracellular domain (NICD) as well as the downstream genes Hes1 and Hes5.	dapt	16-20	hes family bHLH transcription factor 1	Homo sapiens	115-119
26607252-6	2016	The addition of DAPT decreased the expression of Notch intracellular domain (NICD) as well as the downstream genes Hes1 and Hes5.	dapt	16-20	hes family bHLH transcription factor 5	Homo sapiens	124-128
26825631-11	2016	DAPT-induced in vivo Notch signaling blockade, although showing a low efficiency, disrupted the expression patterns of Notch components and effectors in the epididymal epithelium and in spermatozoa, and significantly decreased sperm motility, although not affecting male fertility.	dapt	0-4	notch 1	Mus musculus	21-26
26988682-3	2016	The calcified hVICs were further divided into calcified hVICs group and inhibited calcified hVICs by adding specific Notch1 inhibitor DAPT (50 mumol/L(4 mul/hole))groups and cultured for another 7 days.	dapt	134-138	notch receptor 1	Homo sapiens	117-123
26692291-4	2016	Notch signaling increased after bile duct ligation, and DAPT treatment reduced the expression of CK19, OV6, Sox9, and EpCAM and blocked cholangiocyte proliferation and CLF.	dapt	56-60	keratin 19	Rattus norvegicus	97-101
26692291-4	2016	Notch signaling increased after bile duct ligation, and DAPT treatment reduced the expression of CK19, OV6, Sox9, and EpCAM and blocked cholangiocyte proliferation and CLF.	dapt	56-60	SRY-box transcription factor 9	Rattus norvegicus	108-112
26692291-4	2016	Notch signaling increased after bile duct ligation, and DAPT treatment reduced the expression of CK19, OV6, Sox9, and EpCAM and blocked cholangiocyte proliferation and CLF.	dapt	56-60	epithelial cell adhesion molecule	Rattus norvegicus	118-123
26783939-7	2016	Compared with the LSS group, DAPT reduced LSS-induced plaque formation and intercellular adhesion molecule 1 (ICAM-1) expression.	dapt	29-33	intercellular adhesion molecule 1	Homo sapiens	75-108
26783939-7	2016	Compared with the LSS group, DAPT reduced LSS-induced plaque formation and intercellular adhesion molecule 1 (ICAM-1) expression.	dapt	29-33	intercellular adhesion molecule 1	Homo sapiens	110-116
26783939-9	2016	Notch1 was inhibited by siRNA or DAPT.	dapt	33-37	notch receptor 1	Homo sapiens	0-6
26783939-13	2016	Notch1 inhibition by siRNA or DAPT could reduce these inflammatory responses by reduction of NF-kappaB phosphorylation, upregulation of IkBalpha expression, and inhibition of nuclear translocation of NF-kappaB, while Notch1 activation by DLL-4 had an adverse effect.	dapt	30-34	notch receptor 1	Homo sapiens	0-6
26783939-13	2016	Notch1 inhibition by siRNA or DAPT could reduce these inflammatory responses by reduction of NF-kappaB phosphorylation, upregulation of IkBalpha expression, and inhibition of nuclear translocation of NF-kappaB, while Notch1 activation by DLL-4 had an adverse effect.	dapt	30-34	nuclear factor kappa B subunit 1	Homo sapiens	93-102
26783939-13	2016	Notch1 inhibition by siRNA or DAPT could reduce these inflammatory responses by reduction of NF-kappaB phosphorylation, upregulation of IkBalpha expression, and inhibition of nuclear translocation of NF-kappaB, while Notch1 activation by DLL-4 had an adverse effect.	dapt	30-34	NFKB inhibitor alpha	Homo sapiens	136-144
26783939-13	2016	Notch1 inhibition by siRNA or DAPT could reduce these inflammatory responses by reduction of NF-kappaB phosphorylation, upregulation of IkBalpha expression, and inhibition of nuclear translocation of NF-kappaB, while Notch1 activation by DLL-4 had an adverse effect.	dapt	30-34	nuclear factor kappa B subunit 1	Homo sapiens	200-209
26872378-7	2016	The results of treatment with the gamma-secretase inhibitor DAPT were consistent with the outcomes of PS-1 silencing.	dapt	60-64	presenilin 1	Homo sapiens	102-106
26988682-10	2016	(2) After treatment with DAPT, the calcification and the expression of Notch1, p-NF-kappaB, BMP-2 and BMP-4 were significantly decreased compared to calcification group (all P<0.05).	dapt	25-29	notch receptor 1	Homo sapiens	71-77
26988682-10	2016	(2) After treatment with DAPT, the calcification and the expression of Notch1, p-NF-kappaB, BMP-2 and BMP-4 were significantly decreased compared to calcification group (all P<0.05).	dapt	25-29	bone morphogenetic protein 2	Homo sapiens	92-97
26988682-10	2016	(2) After treatment with DAPT, the calcification and the expression of Notch1, p-NF-kappaB, BMP-2 and BMP-4 were significantly decreased compared to calcification group (all P<0.05).	dapt	25-29	bone morphogenetic protein 4	Homo sapiens	102-107
26742640-7	2016	We observed that differentiation of SH-SY5Y human neuroblastoma cells induced by retinoic acid (RA), the phorbol ester PMA, or the gamma-secretase inhibitor DAPT resulted in an electrophoretic mobility shift of Fe65.	dapt	157-161	amyloid beta precursor protein binding family B member 1	Homo sapiens	211-215
27158355-0	2016	DAPT mediates atoh1 expression to induce hair cell-like cells.	dapt	0-4	atonal bHLH transcription factor 1	Homo sapiens	14-19
27158355-6	2016	DAPT, an inhibitor of Notch signaling, enhances the expression of Atoh1 indirectly, which in turn promotes the induction of a HC fate.	dapt	0-4	atonal bHLH transcription factor 1	Homo sapiens	66-71
27158355-8	2016	Taken together, our findings demonstrated that DAPT is sufficient to induce HC-like cells via enhancing of the expression of Atoh1 to inhibit the progression of HC apoptosis and to induce new HC formation.	dapt	47-51	atonal bHLH transcription factor 1	Homo sapiens	125-130
26815196-6	2016	In this study we attempted to determine if the [ (13)C]-pantoprazole breath test (Ptz-BT) can evaluate changes in CYP2C19 enzyme activity (phenoconversion) following the administration of PPI in coronary artery disease (CAD) patients treated with DAPT after PCI.	dapt	247-251	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	114-121
26400205-8	2016	The Notch inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) reduced the expression of NICD, Hes-1 and proinflammatory cytokines.	dapt	20-89	hes family bHLH transcription factor 1	Mus musculus	129-134
26400205-8	2016	The Notch inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) reduced the expression of NICD, Hes-1 and proinflammatory cytokines.	dapt	91-95	hes family bHLH transcription factor 1	Mus musculus	129-134
26566963-7	2016	Furthermore, Jagged1 induced keratinocyte differentiation and upregulated the expression of fibrotic factors, including transforming growth factors beta1 and beta2 , insulin-like growth factor-1, connective tissue growth factor, vascular endothelial growth factor and epidermal growth factor, while DAPT (a Notch inhibitor) significantly suppressed these processes.	dapt	299-303	jagged canonical Notch ligand 1	Homo sapiens	13-20
27590033-1	2016	Dual antiplatelet therapy (DAPT) with acetylsalicylic acid and a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) reduces thrombotic events in patients with acute coronary syndrome (ACS), but it is also associated with an increased risk of bleeding complications.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	65-70
26716652-0	2016	Combination therapy of RY10-4 with the gamma-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer.	dapt	65-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-100
26716652-6	2016	RY10-4 plus DAPT increases apoptosis in both HER2-overexpressing cell lines by two-fold compared to RY10-4 alone, while DAPT alone has no significant effects on apoptosis.	dapt	12-16	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
26716652-8	2016	Here we report that the combination of RY10-4 and DAPT exhibit additive suppression on AKT phosphorylation, contributing to the anti-cancer effects.	dapt	50-54	AKT serine/threonine kinase 1	Homo sapiens	87-90
26984587-3	2016	Indeed, dual antiplatelet therapy (DAPT) with aspirin and the P2Y12inhibitor clopidogrel, which has represented the mainstay of treatment for many years, has significantly reduced the incidence of recurrent atherothrombotic events.	dapt	35-39	purinergic receptor P2Y12	Homo sapiens	62-67
25851472-1	2016	BACKGROUND: There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients receiving dual antiplatelet therapy (DAPT).	dapt	152-156	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	62-69
26662286-7	2016	Either silencing of Notch1 by siRNA or pharmacological inhibition of Notch signaling by DAPT prevented the loss of cell viability, and induction of apoptosis, and enhanced expression Notch1, Hes1 and MCP-1 by LPC in HUVECs.	dapt	88-92	hes family bHLH transcription factor 1	Homo sapiens	191-195
26662286-7	2016	Either silencing of Notch1 by siRNA or pharmacological inhibition of Notch signaling by DAPT prevented the loss of cell viability, and induction of apoptosis, and enhanced expression Notch1, Hes1 and MCP-1 by LPC in HUVECs.	dapt	88-92	C-C motif chemokine ligand 2	Homo sapiens	200-205
26062798-8	2015	In histological analyses, treatment with DAPT reduced the number of cartilage lesions present and the expressions of MMP-13, CII, Notch1, and JAG1.	dapt	41-45	matrix metallopeptidase 13	Rattus norvegicus	117-123
26728369-8	2016	Compared to the untreated group, Notch1 expression decreased in a dose-dependent manner in the valsartan or DAPT treated group under high glucose after 24 hours.	dapt	108-112	notch receptor 1	Rattus norvegicus	33-39
26728369-9	2016	After pre-treatment by either valsartan or DAPT in the high glucose group, secretion of TGF-beta and FN obviously decreased as compared to the untreated group.	dapt	43-47	transforming growth factor, beta 1	Rattus norvegicus	88-96
26728369-9	2016	After pre-treatment by either valsartan or DAPT in the high glucose group, secretion of TGF-beta and FN obviously decreased as compared to the untreated group.	dapt	43-47	fibronectin 1	Rattus norvegicus	101-103
26564402-12	2016	Among DAPT-treated patients, ticagrelor has emerged as the preferred P2Y12 antagonist in patients undergoing angiography, whereas clopidogrel tended to be prescribed to patients treated non-invasively.	dapt	6-10	purinergic receptor P2Y12	Homo sapiens	69-74
26062798-8	2015	In histological analyses, treatment with DAPT reduced the number of cartilage lesions present and the expressions of MMP-13, CII, Notch1, and JAG1.	dapt	41-45	notch receptor 1	Rattus norvegicus	130-136
26062798-8	2015	In histological analyses, treatment with DAPT reduced the number of cartilage lesions present and the expressions of MMP-13, CII, Notch1, and JAG1.	dapt	41-45	jagged canonical Notch ligand 1	Rattus norvegicus	142-146
26572615-10	2015	nr2f1b expression is increased in rbpsuh morphants and DAPT-treatment embryos suggested nr2f1b is negatively regulated by Notch activity.	dapt	55-59	nuclear receptor subfamily 2, group F, member 1b	Danio rerio	88-94
26410397-5	2015	The specific inhibition of Notch signaling pathway by the intravitreal injection of gamma-secretase inhibitor DAPT attenuated RPE cells-induced PVR formation as demonstrated by the decreased expression of alpha-SMA, and inhibited M2 type macrophage infiltation as demonstrated by the decreased expression of Arg-1.	dapt	110-114	arginase 1	Homo sapiens	308-313
26540052-7	2015	On the other hand, Notch1 inhibition (DAPT) dose-dependently decreases survivin, stimulates differentiation, and reduces keratinocyte proliferation in samples from donors of all ages.	dapt	38-42	notch receptor 1	Homo sapiens	19-25
25914224-11	2015	Experiments with the pan-Notch inhibitor DAPT, and soluble Jagged-1-Fc protein provided evidence that Notch-1 signaling activates CD44, Slug, and Smad-3 via a cascade of other Notch-receptors through induction of Jagged-1 expression.	dapt	41-45	notch receptor 1	Homo sapiens	102-109
26722328-0	2015	Gastric tumor-initiating CD44+ cells and epithelial-mesenchymal transition are inhibited by gamma-secretase inhibitor DAPT.	dapt	118-122	CD44 molecule (Indian blood group)	Homo sapiens	25-29
26722328-6	2015	To investigate the role of the Notch1 pathway in GCSCs, CD44+ cells were treated with the gamma-secretase inhibitor DAPT.	dapt	116-120	CD44 molecule (Indian blood group)	Homo sapiens	56-60
26722328-7	2015	DAPT treatment inhibited the expression of the Notch1 downstream target Hes1 and EMT markers, suppressed the properties of CSCs and impaired the invasion and proliferation capabilities of CD44+ cells.	dapt	0-4	notch receptor 1	Homo sapiens	47-53
26722328-7	2015	DAPT treatment inhibited the expression of the Notch1 downstream target Hes1 and EMT markers, suppressed the properties of CSCs and impaired the invasion and proliferation capabilities of CD44+ cells.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	72-76
26722328-7	2015	DAPT treatment inhibited the expression of the Notch1 downstream target Hes1 and EMT markers, suppressed the properties of CSCs and impaired the invasion and proliferation capabilities of CD44+ cells.	dapt	0-4	CD44 molecule (Indian blood group)	Homo sapiens	188-192
26722328-8	2015	In addition, intraperitoneal treatment with DAPT effectively inhibited the growth of CD44+ cell xenograft tumors.	dapt	44-48	CD44 molecule (Indian blood group)	Homo sapiens	85-89
26573194-9	2015	DAPT treatment led to a decrease above the index serum levels of HMGB1 (6.22+/-0.71) and IL-10 (252.06+/-57.63), and of expression of Notch 1 (mRNA: 3.20+/-0.68), NICD (protein: 0.42+/-0.05), and Hes5 (mRNA: 4.72+/-0.67; protein: 0.84+/-0.09) (P<0.01 or <0.05).	dapt	0-4	high mobility group box 1	Mus musculus	65-70
26299339-9	2015	Cell survival increased with the Notch signaling inhibitor DAPT or Notch2 siRNA and NICD2 attenuated the NSC23766 effect.	dapt	59-63	notch 2	Mus musculus	33-38
26573194-9	2015	DAPT treatment led to a decrease above the index serum levels of HMGB1 (6.22+/-0.71) and IL-10 (252.06+/-57.63), and of expression of Notch 1 (mRNA: 3.20+/-0.68), NICD (protein: 0.42+/-0.05), and Hes5 (mRNA: 4.72+/-0.67; protein: 0.84+/-0.09) (P<0.01 or <0.05).	dapt	0-4	interleukin 10	Mus musculus	89-94
26573194-9	2015	DAPT treatment led to a decrease above the index serum levels of HMGB1 (6.22+/-0.71) and IL-10 (252.06+/-57.63), and of expression of Notch 1 (mRNA: 3.20+/-0.68), NICD (protein: 0.42+/-0.05), and Hes5 (mRNA: 4.72+/-0.67; protein: 0.84+/-0.09) (P<0.01 or <0.05).	dapt	0-4	notch 1	Mus musculus	134-141
26573194-9	2015	DAPT treatment led to a decrease above the index serum levels of HMGB1 (6.22+/-0.71) and IL-10 (252.06+/-57.63), and of expression of Notch 1 (mRNA: 3.20+/-0.68), NICD (protein: 0.42+/-0.05), and Hes5 (mRNA: 4.72+/-0.67; protein: 0.84+/-0.09) (P<0.01 or <0.05).	dapt	0-4	hes family bHLH transcription factor 5	Mus musculus	196-200
26362310-7	2015	In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002).	dapt	145-149	notch receptor 1	Homo sapiens	54-60
26362310-7	2015	In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002).	dapt	145-149	notch receptor 1	Homo sapiens	92-98
26362310-7	2015	In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002).	dapt	145-149	ATP binding cassette subfamily C member 1	Homo sapiens	196-200
26182882-4	2015	Remarkably, blockade of Notch-1 signaling with the specific inhibitor DAPT suppressed astrocytic proliferation.	dapt	70-74	notch receptor 1	Rattus norvegicus	24-31
26206582-4	2015	In this study, we aimed to analyze the effect of the nNav1.5 inhibitor phenytoin and Notch signal inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine-t-butyl ester (DAPT) on triple negative breast cancer cell line (MDA-MB-231) via inhibition of nNav1.5 VGSC activity and Notch signaling, respectively.	dapt	179-183	notch receptor 4	Homo sapiens	85-90
26206582-9	2015	Meanwhile, the results showed that the MMP9 activity and the ratio of MMP9 mRNA to TIMP1 mRNA were only decreased by DAPT.	dapt	117-121	matrix metallopeptidase 9	Homo sapiens	39-43
26206582-9	2015	Meanwhile, the results showed that the MMP9 activity and the ratio of MMP9 mRNA to TIMP1 mRNA were only decreased by DAPT.	dapt	117-121	matrix metallopeptidase 9	Homo sapiens	70-74
26206582-9	2015	Meanwhile, the results showed that the MMP9 activity and the ratio of MMP9 mRNA to TIMP1 mRNA were only decreased by DAPT.	dapt	117-121	TIMP metallopeptidase inhibitor 1	Homo sapiens	83-88
26182882-5	2015	In addition, both expression and secretion of inflammatory factor IL-1beta was inhibited in DAPT-pretreated astrocytes, while no significant change in TNF-alpha expression was detected.	dapt	92-96	interleukin 1 beta	Rattus norvegicus	66-74
26182882-6	2015	Most interestingly, GFAP and VEGF expression was suppressed by DAPT pretreatment in hypoxic astrocytes and further confirmed in neonatal rats following hypoxic brain injury.	dapt	63-67	glial fibrillary acidic protein	Rattus norvegicus	20-24
26182882-6	2015	Most interestingly, GFAP and VEGF expression was suppressed by DAPT pretreatment in hypoxic astrocytes and further confirmed in neonatal rats following hypoxic brain injury.	dapt	63-67	vascular endothelial growth factor A	Rattus norvegicus	29-33
25952972-9	2015	We found that inhibition of Notch signaling by DAPT efficiently rescued notochord developmental defect of Egfl6 deficiency embryos.	dapt	47-51	notch receptor 2	Danio rerio	28-33
26094772-9	2015	Using DAPT (Notch1 inhibitor) to knock down Notch1 expression, morphological and molecular typical changes of the EMT were detected in vitro.	dapt	6-10	notch receptor 1	Homo sapiens	12-18
26094772-9	2015	Using DAPT (Notch1 inhibitor) to knock down Notch1 expression, morphological and molecular typical changes of the EMT were detected in vitro.	dapt	6-10	notch receptor 1	Homo sapiens	44-50
26094772-14	2015	The in vivo data showed that inhibition of Notch signaling by DAPT treatment effectively suppressed metastatic tumor growth, metabolic activity and invasion.	dapt	62-66	notch receptor 1	Homo sapiens	43-48
24989714-8	2015	CONCLUSION: Our results hint VASP-phosphorylation assay as a relevant method for guiding and tailoring DAPT.	dapt	103-107	vasodilator stimulated phosphoprotein	Homo sapiens	29-33
26137210-1	2015	Dual antiplatelet therapy (DAPT), which includes the combination of aspirin and a P2Y12 platelet receptor inhibitor, is a well-established antiplatelet regimen in the treatment of patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	82-87
26075891-8	2015	In support of this notion, we found that preventing NPC differentiation by DAPT, a gamma-secretase inhibitor that inhibits Notch signaling pathway, was effective to maintain and expand Six2(+)-NPC in P1 aggregates by up to 65-fold.	dapt	75-79	sine oculis-related homeobox 2	Mus musculus	185-189
25809653-1	2015	BACKGROUND: Dual-antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor, mostly clopidogrel, is the default therapy in both acute coronary syndrome (ACS) and after intracoronary stents.	dapt	39-43	purinergic receptor P2Y12	Homo sapiens	64-69
26062426-4	2015	After Notch pathway was blocked with gamma-secretase inhibitor DAPT, expressions of Notch intracellular domain (NICD), Delta-like 4 (DLL4), hairy enhancer of split 1 (Hes1), matrix metalloproteinase 9 (MMP-9) in IL-23-treated TE-1 cells were measured by Western blotting.	dapt	63-67	notch receptor 1	Homo sapiens	6-11
25849374-3	2015	Here, we show that DAPT accelerates human embryonic stem cell differentiation and induces expression of the ectoderm protein AP2.	dapt	19-23	transcription factor AP-2 alpha	Homo sapiens	125-128
25775018-10	2015	Vascular collapse in zebrafish embryos was partially rescued by global Notch inhibition with DAPT suggesting that disruption of normal Notch signaling by CSA may be linked to vascular collapse.	dapt	93-97	notch receptor 1	Homo sapiens	71-76
25742746-6	2015	Inhibition of FoxM1 by Thiostrepton and of Notch1 by DAPT downregulated the sphere formation ability of cells.	dapt	53-57	notch receptor 1	Homo sapiens	43-49
25637797-11	2015	It turned out that DAPT significantly prevented the Notch1 activation in hUCMSCs after co-culture with OGD neurons.	dapt	19-23	notch receptor 1	Homo sapiens	52-58
25637797-12	2015	More importantly, the pro-angiogenic effect of hUCMSCs was remarkably abolished by DAPT addition as demonstrated by inhibited capillary-like tube formation and less VEGF-A production.	dapt	83-87	vascular endothelial growth factor A	Homo sapiens	165-171
25637797-13	2015	Regarding how Notch1 signaling was linked with VEGF-A secretion, we provided some clue that Notch1 effector Hes1 mRNA expression was significantly up-regulated by OGD-neuron co-culturing and down-regulated after additional treatment of DAPT.	dapt	236-240	notch receptor 1	Homo sapiens	14-20
25637797-13	2015	Regarding how Notch1 signaling was linked with VEGF-A secretion, we provided some clue that Notch1 effector Hes1 mRNA expression was significantly up-regulated by OGD-neuron co-culturing and down-regulated after additional treatment of DAPT.	dapt	236-240	vascular endothelial growth factor A	Homo sapiens	47-53
25637797-13	2015	Regarding how Notch1 signaling was linked with VEGF-A secretion, we provided some clue that Notch1 effector Hes1 mRNA expression was significantly up-regulated by OGD-neuron co-culturing and down-regulated after additional treatment of DAPT.	dapt	236-240	notch receptor 1	Homo sapiens	92-98
25637797-13	2015	Regarding how Notch1 signaling was linked with VEGF-A secretion, we provided some clue that Notch1 effector Hes1 mRNA expression was significantly up-regulated by OGD-neuron co-culturing and down-regulated after additional treatment of DAPT.	dapt	236-240	hes family bHLH transcription factor 1	Homo sapiens	108-112
25775018-10	2015	Vascular collapse in zebrafish embryos was partially rescued by global Notch inhibition with DAPT suggesting that disruption of normal Notch signaling by CSA may be linked to vascular collapse.	dapt	93-97	notch receptor 1	Homo sapiens	135-140
25775018-10	2015	Vascular collapse in zebrafish embryos was partially rescued by global Notch inhibition with DAPT suggesting that disruption of normal Notch signaling by CSA may be linked to vascular collapse.	dapt	93-97	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	154-157
25878596-9	2015	These inhibitory effects were identical to DAPT, a Notch signaling pathway inhibitor.	dapt	43-47	notch receptor 1	Rattus norvegicus	51-56
25266323-7	2015	DAPT plus warfarin was an independent risk factor for major bleeding in a multivariate Cox hazard regression model after adjustment for age, gender, and the type of AF (hazard ratio: 4.20; 95% confidence interval: 1.13-17.27; p=0.033).	dapt	0-4	cytochrome c oxidase subunit 8A	Homo sapiens	87-90
25997279-5	2015	We also used qRT-PCR to detect the effect of the DAPT on Tuj1 and GFAP mRNA transcription in the GE6.	dapt	49-53	glial fibrillary acidic protein	Homo sapiens	66-70
25467922-1	2015	Dual antiplatelet therapy (DAPT), which is the combination of aspirin and a platelet P2Y12 inhibitor, is the cornerstone of secondary prevention in ischemic heart disease requiring intracoronary stenting.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	85-90
25485537-11	2015	After inactivating Notch signal by DAPT, Th17 cells and Th17/Treg ratio were dose dependently decreased and accompanied by the reduction of IL-17 in culture supernatants and RORgammat mRNA expression in ITP patients.	dapt	35-39	interleukin 17A	Homo sapiens	140-145
25485537-13	2015	We also present evidence that the effect of DAPT inhibition on the Th17 cell response was associated with downregulation of RORgammat and IL-17 transcription using human in vitro polarization.	dapt	44-48	interleukin 17A	Homo sapiens	138-143
25967959-8	2015	The protective effect of spironolactone against EndMT could be attenuated by blocking the Notch signal pathway with DAPT (p<0.01).	dapt	116-120	notch receptor 1	Homo sapiens	90-95
26328484-7	2015	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the augmentation of Notch 1 and Hes 1 protein was ameliorated, and the proliferation-inducing effect of osthole was abolished, suggesting that the effects of osthole are at least in part mediated by activation of the Notch pathway.	dapt	74-78	notch 1	Mus musculus	14-19
26328484-7	2015	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the augmentation of Notch 1 and Hes 1 protein was ameliorated, and the proliferation-inducing effect of osthole was abolished, suggesting that the effects of osthole are at least in part mediated by activation of the Notch pathway.	dapt	74-78	notch 1	Mus musculus	100-107
26328484-7	2015	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the augmentation of Notch 1 and Hes 1 protein was ameliorated, and the proliferation-inducing effect of osthole was abolished, suggesting that the effects of osthole are at least in part mediated by activation of the Notch pathway.	dapt	74-78	hes family bHLH transcription factor 1	Mus musculus	112-117
26328484-7	2015	However, when Notch activity was blocked by the gamma-secretase inhibitor DAPT, the augmentation of Notch 1 and Hes 1 protein was ameliorated, and the proliferation-inducing effect of osthole was abolished, suggesting that the effects of osthole are at least in part mediated by activation of the Notch pathway.	dapt	74-78	notch 1	Mus musculus	100-105
25773953-8	2015	Administration of DAPT in obese mice significantly reduced serum VEGFR-1 and leptin concentrations and increased serum NO level (p < 0.05).	dapt	18-22	FMS-like tyrosine kinase 1	Mus musculus	65-72
25350775-2	2015	However, higher on-treatment platelet reactivity was associated with lower plasma miR-223 in patients with coronary artery disease (CAD) on dual antiplatelet therapy (DAPT) including clopidogrel and aspirin.	dapt	167-171	microRNA 223	Homo sapiens	82-89
26645720-9	2015	While, the expression of MVH and OCT4 were reduced when the ovaries were treated with DAPT and the levels were attenuated with increasing dose of DAPT.	dapt	86-90	DEAD box helicase 4	Mus musculus	25-28
26645720-9	2015	While, the expression of MVH and OCT4 were reduced when the ovaries were treated with DAPT and the levels were attenuated with increasing dose of DAPT.	dapt	86-90	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	33-37
26645720-9	2015	While, the expression of MVH and OCT4 were reduced when the ovaries were treated with DAPT and the levels were attenuated with increasing dose of DAPT.	dapt	146-150	DEAD box helicase 4	Mus musculus	25-28
26645720-9	2015	While, the expression of MVH and OCT4 were reduced when the ovaries were treated with DAPT and the levels were attenuated with increasing dose of DAPT.	dapt	146-150	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	33-37
25446033-5	2015	The expression of her2 required Notch activation, as revealed by a Notch-defective mutant and a chemical inhibitor, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	116-185	hairy-related 2	Danio rerio	18-22
25446033-5	2015	The expression of her2 required Notch activation, as revealed by a Notch-defective mutant and a chemical inhibitor, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	187-191	hairy-related 2	Danio rerio	18-22
25342127-9	2015	These effects were partly attributable to the ability of relaxin to upregulate Notch-1 signaling; indeed, blockade of Notch-1 activation with the specific inhibitor DAPT reduced relaxin-induced cardioprotection during hypoxia and reoxygenation.	dapt	165-169	notch receptor 1	Rattus norvegicus	79-86
25342127-9	2015	These effects were partly attributable to the ability of relaxin to upregulate Notch-1 signaling; indeed, blockade of Notch-1 activation with the specific inhibitor DAPT reduced relaxin-induced cardioprotection during hypoxia and reoxygenation.	dapt	165-169	notch receptor 1	Rattus norvegicus	118-125
26202359-7	2015	Furthermore, Notch inhibitor DAPT induced early autophagy by acting on PTEN-PI3K/Akt/mTOR pathway.	dapt	29-33	AKT serine/threonine kinase 1	Homo sapiens	81-84
26202359-7	2015	Furthermore, Notch inhibitor DAPT induced early autophagy by acting on PTEN-PI3K/Akt/mTOR pathway.	dapt	29-33	mechanistic target of rapamycin kinase	Homo sapiens	85-89
26063974-8	2015	Inhibition of Notch signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenyl glycinet-butyl ester (DAPT) induced significantly decreased expressions of PD-1 and IL-10 in the LPS-tolerant cell model.	dapt	104-108	IL10	Sus scrofa	166-171
25350775-3	2015	Our aim was to compare plasma miR-223 and platelet reactivity in CAD patients on DAPT with newer P2Y12 antagonists vs. clopidogrel.	dapt	81-85	microRNA 223	Homo sapiens	30-37
25350775-3	2015	Our aim was to compare plasma miR-223 and platelet reactivity in CAD patients on DAPT with newer P2Y12 antagonists vs. clopidogrel.	dapt	81-85	purinergic receptor P2Y12	Homo sapiens	97-102
25350775-12	2015	On the contrary, more potent platelet inhibition associated mainly with newer P2Y12 antagonists appears to coincide with higher miR-223 relative to the subjects with attenuated responsiveness to DAPT.	dapt	195-199	purinergic receptor P2Y12	Homo sapiens	78-83
25433026-8	2015	The BAX:BCLXL ratio was increased in CL treated with DAPT and the presence of progesterone reversed this effect.	dapt	53-57	BCL2 associated X, apoptosis regulator	Rattus norvegicus	4-7
25433026-8	2015	The BAX:BCLXL ratio was increased in CL treated with DAPT and the presence of progesterone reversed this effect.	dapt	53-57	Bcl2-like 1	Rattus norvegicus	8-13
25433026-10	2015	To demonstrate that the action of DAPT is specifically related with the inhibition of Notch, CLs were incubated with DLL4 antibody and a decrease in progesterone production was detected.	dapt	34-38	delta like canonical Notch ligand 4	Rattus norvegicus	117-121
25433026-9	2015	In addition, phosphorylation of AKT was inhibited in CL treated with DAPT, but had no effect on ERK activation.	dapt	69-73	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
25433026-10	2015	To demonstrate that the action of DAPT is specifically related with the inhibition of Notch, CLs were incubated with DLL4 antibody and a decrease in progesterone production was detected.	dapt	34-38	notch receptor 1	Rattus norvegicus	86-91
25674544-2	2015	Noteworthy, PCI patients require a dual antiplatelet therapy (DAPT), with aspirine and a thienopiridine (clopidogrel, prasugrel, ticagrelor), because of the high risk of stent thrombosis (ST), myocardial infarction (MI) and death, especially within the first month.	dapt	62-66	serpin family A member 5	Homo sapiens	12-15
25088840-7	2015	Furthermore, this difference was eliminated by adding the Notch1 signaling pathway inhibitor DAPT to the 3D static culture.	dapt	93-97	notch receptor 1	Homo sapiens	58-64
25104574-6	2014	Moreover, addition of DAPT, a specific inhibitor of Notch signaling, partially rescued the fusion defects in Tgf-beta3 null mutant palatal shelves.	dapt	22-26	transforming growth factor, beta 3	Mus musculus	109-118
25367504-1	2014	Use of dual antiplatelet therapy (DAPT; the combination of aspirin and an inhibitor of platelet P2Y12) is the key pharmacological component in the management of acute coronary syndrome and percutaneous coronary intervention (PCI) with stent implantation, but the optimal treatment duration is still unclear.	dapt	34-38	purinergic receptor P2Y12	Homo sapiens	96-101
25257945-8	2014	Slug and Bcl-xL protein expressions were significantly reduced in DAPT treated HT 29 cells.	dapt	66-70	snail family transcriptional repressor 2	Homo sapiens	0-4
25257945-8	2014	Slug and Bcl-xL protein expressions were significantly reduced in DAPT treated HT 29 cells.	dapt	66-70	BCL2 like 1	Homo sapiens	9-15
24825564-7	2014	Prophylactic N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) administration, a Notch signaling inhibitor, protected against the effects of hypoxia.	dapt	13-82	notch receptor 3	Homo sapiens	108-113
25313563-10	2014	In parallel, DAPT dramatically augmented the expression of Wnt3a, Wnt11, BMP2, and BMP4.	dapt	13-17	wingless-type MMTV integration site family, member 3A	Mus musculus	59-64
25073953-5	2014	Moreover, real-time PCR analysis of CyclinD1, Hes1 and MUC2 was done in HT29 cells upon N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) treatment.	dapt	160-164	cyclin D1	Homo sapiens	36-44
25073953-5	2014	Moreover, real-time PCR analysis of CyclinD1, Hes1 and MUC2 was done in HT29 cells upon N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) treatment.	dapt	160-164	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	55-59
25073953-7	2014	Hes1 transcript levels were decreased 1.5- and 7.1-fold in 12.5 and 25 microM DAPT-treated HT29 cells.	dapt	78-82	hes family bHLH transcription factor 1	Homo sapiens	0-4
25073953-8	2014	CyclinD1 transcript levels decreased 1.2- and 1.6-fold, and MUC2 transcript level increased 4.3- and 7.5-fold in 12.5 and 25 microM DAPT-treated HT29 cells.	dapt	132-136	cyclin D1	Homo sapiens	0-8
25073953-8	2014	CyclinD1 transcript levels decreased 1.2- and 1.6-fold, and MUC2 transcript level increased 4.3- and 7.5-fold in 12.5 and 25 microM DAPT-treated HT29 cells.	dapt	132-136	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	60-64
25073953-10	2014	Moreover, the inhibition of Notch1 signaling by DAPT leads to the arrest of cell proliferation and induces apoptosis leading to the upregulation of MUC2, a secretory cell lineage marker.	dapt	48-52	notch receptor 1	Homo sapiens	28-34
25073953-10	2014	Moreover, the inhibition of Notch1 signaling by DAPT leads to the arrest of cell proliferation and induces apoptosis leading to the upregulation of MUC2, a secretory cell lineage marker.	dapt	48-52	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	148-152
25349182-4	2014	METHODS AND RESULTS: Treatment with pharmacological Notch inhibitor (DAPT [N-(N-[3,5-difluorophenacetyl]-L-alanyl)-S-phenylglycine t-butyl ester]) at day 3 or 8 of angiotensin II infusion arrested the progression of AAA in Apoe(-/-) mice, as demonstrated by a decreased luminal diameter and aortic width.	dapt	69-73	apolipoprotein E	Mus musculus	223-227
25349182-5	2014	The abdominal aortas of Apoe(-/-) mice treated with DAPT showed decreased expression of matrix metalloproteinases and presence of elastin precursors including tropoelastin and hyaluronic acid.	dapt	52-56	apolipoprotein E	Mus musculus	24-28
25349182-6	2014	Marginal adventitial thickening observed in the aorta of DAPT-treated Apoe(-/-) mice was not associated with increased macrophage content, as observed in the mice treated with angiotensin II alone.	dapt	57-61	apolipoprotein E	Mus musculus	70-74
25349182-9	2014	Protein expression of transforming growth factor beta2 and its downstream effector pSmad2 also increased in DAPT-treated Apoe(-/-) mice, indicating a potential link between Notch and transforming growth factor beta2 signaling in the M2 differentiation of macrophages.	dapt	108-112	transforming growth factor, beta 2	Mus musculus	22-54
25349182-9	2014	Protein expression of transforming growth factor beta2 and its downstream effector pSmad2 also increased in DAPT-treated Apoe(-/-) mice, indicating a potential link between Notch and transforming growth factor beta2 signaling in the M2 differentiation of macrophages.	dapt	108-112	apolipoprotein E	Mus musculus	121-125
25349182-9	2014	Protein expression of transforming growth factor beta2 and its downstream effector pSmad2 also increased in DAPT-treated Apoe(-/-) mice, indicating a potential link between Notch and transforming growth factor beta2 signaling in the M2 differentiation of macrophages.	dapt	108-112	transforming growth factor, beta 2	Mus musculus	183-215
25313563-10	2014	In parallel, DAPT dramatically augmented the expression of Wnt3a, Wnt11, BMP2, and BMP4.	dapt	13-17	wingless-type MMTV integration site family, member 11	Mus musculus	66-71
25313563-10	2014	In parallel, DAPT dramatically augmented the expression of Wnt3a, Wnt11, BMP2, and BMP4.	dapt	13-17	bone morphogenetic protein 2	Mus musculus	73-77
25313563-10	2014	In parallel, DAPT dramatically augmented the expression of Wnt3a, Wnt11, BMP2, and BMP4.	dapt	13-17	bone morphogenetic protein 4	Mus musculus	83-87
24894120-3	2014	Acetylsalicylic acid (ASA) alone or in combination with a platelet P2Y12 inhibitor (dual antiplatelet therapy [DAPT]) has become the clinically accepted antithrombotic prophylaxis for patients post-ACS.	dapt	111-115	purinergic receptor P2Y12	Homo sapiens	67-72
24754775-7	2014	Multicilin and Forkhead box J1 expression and ciliated cell differentiation were restored in submerged and hypoxic cells upon treatment with the gamma-secretase inhibitor, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester (DAPT), which suggested that Notch signaling was involved.	dapt	254-258	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	0-10
24972386-7	2014	The pharmacological blockade of PI3K/Akt survival pathway by LY294002 fully inhibited in vitro and in vivo angiogenesis induced by mCRP/Notch-3/Fc combination while blocking Notch signalling by gamma-secretase inhibitor (DAPT) partially inhibited mCRP/Notch-3/Fc-induced angiogenesis.	dapt	221-225	AKT serine/threonine kinase 1	Bos taurus	37-40
24929042-7	2014	The neuronal differentiation effects of SAL on D1 cells were promoted by a Notch signaling antagonist, DAPT, but attenuated by a BMP signaling pathway antagonist, Noggin.	dapt	103-107	satin-like	Mus musculus	40-43
24992925-10	2014	After blocking NICD with a gamma-secretase inhibitor (DAPT) MP still inhibited the expression of Hes1.	dapt	54-58	hes family bHLH transcription factor 1	Rattus norvegicus	97-101
24939218-5	2014	The notch1 inhibitor DAPT and the downregulation of notch1 by shRNA promoted osteogenesis in MM-MSCs.	dapt	21-25	notch receptor 1	Homo sapiens	4-10
25157918-12	2014	We further showed that nr2f1a likely interact with Notch signaling by examining nr2f1a expression in rbpsuh morphants and DAPT-treatment embryos.	dapt	122-126	nuclear receptor subfamily 2, group F, member 1a	Danio rerio	23-29
25130830-3	2014	The inhibitor DAPT was used to block Notch signaling pathway, and the effect of the pathway on VEGF promoting proliferation of MSC was observed.	dapt	14-18	notch receptor 1	Rattus norvegicus	37-42
25130830-3	2014	The inhibitor DAPT was used to block Notch signaling pathway, and the effect of the pathway on VEGF promoting proliferation of MSC was observed.	dapt	14-18	vascular endothelial growth factor A	Rattus norvegicus	95-99
25130830-6	2014	The results indicated that the cells survival rate MSC in DAPT group and VEGF+DAPT group was low in each time point (24 h, 48 h, 72 h), the cell number decreased, and the cells became rounded.	dapt	78-82	vascular endothelial growth factor A	Rattus norvegicus	73-77
25130830-8	2014	Flk-1 mRNA level in DAPT group and VEGF+DAPT group was slightly lower, but the difference was not statistically significant (P > 0.05).	dapt	20-24	kinase insert domain receptor	Rattus norvegicus	0-5
25130830-8	2014	Flk-1 mRNA level in DAPT group and VEGF+DAPT group was slightly lower, but the difference was not statistically significant (P > 0.05).	dapt	40-44	vascular endothelial growth factor A	Rattus norvegicus	35-39
25130830-9	2014	It is concluded that Notch signaling pathway plays an important role in promoting the proliferation of rat MSC, treated with VEGF, however, the DAPT can weaken this effect.	dapt	144-148	notch receptor 1	Rattus norvegicus	21-26
25130830-9	2014	It is concluded that Notch signaling pathway plays an important role in promoting the proliferation of rat MSC, treated with VEGF, however, the DAPT can weaken this effect.	dapt	144-148	vascular endothelial growth factor A	Rattus norvegicus	125-129
24805975-5	2014	When treated with DAPT, a specific inhibitor of Notch receptor cleavage, expression of Notch1 and Jagged2 were downregulated in a dose-dependent manner, which was accompanied by substantial cell growth arrest, as indicated by the Cell Counting kit-8 assay.	dapt	18-22	notch receptor 1	Homo sapiens	87-93
24814170-5	2014	METHODS: Condylar cartilage explants were cultured over serum-free DMEM containing either 0 or 50nM DAPT, a Notch signal inhibitor.	dapt	100-104	notch receptor 1	Homo sapiens	108-113
25063285-7	2014	TSC of CD133(+) was significantly reduced after DAPT treated SHG-44 cells.	dapt	48-52	prominin 1	Homo sapiens	7-12
25063285-8	2014	The expression of protein and mRNA of Notch-1, Delta-1 and Hes-1 were gradually downregulated with the increase of DAPT doses.	dapt	115-119	notch receptor 1	Homo sapiens	38-54
25063285-8	2014	The expression of protein and mRNA of Notch-1, Delta-1 and Hes-1 were gradually downregulated with the increase of DAPT doses.	dapt	115-119	hes family bHLH transcription factor 1	Homo sapiens	59-64
25063285-9	2014	CONCLUSIONS: DAPT can downregulate these key factor in Notch signaling pathway, reduce the TSC of CD133+ and inhibit the proliferation of SHG-44 cells.	dapt	13-17	notch receptor 1	Homo sapiens	55-60
25063285-9	2014	CONCLUSIONS: DAPT can downregulate these key factor in Notch signaling pathway, reduce the TSC of CD133+ and inhibit the proliferation of SHG-44 cells.	dapt	13-17	prominin 1	Homo sapiens	98-103
24805975-5	2014	When treated with DAPT, a specific inhibitor of Notch receptor cleavage, expression of Notch1 and Jagged2 were downregulated in a dose-dependent manner, which was accompanied by substantial cell growth arrest, as indicated by the Cell Counting kit-8 assay.	dapt	18-22	jagged canonical Notch ligand 2	Homo sapiens	98-105
24805975-9	2014	The inhibition of the Notch signaling pathway by DAPT represents a potentially attractive strategy for the therapy of retinoblastoma.	dapt	49-53	notch receptor 1	Homo sapiens	22-27
25221582-3	2014	In the present study, PC12 cells were cultured with different doses (0, 0.1, 1.0, 10 and 100 nmol/L) of N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, a Notch-1 signaling pathway inhibitor, for 30 minutes.	dapt	104-173	notch receptor 1	Rattus norvegicus	177-184
25286679-8	2014	RT-PCR analysis demonstrated that the expression of Notch1 mRNA decreased significantly in the DAPT groups, with an inhibition rate of 10.23%, 20.50%, and 38.83% for the three DAPT groups, respectively.	dapt	95-99	notch receptor 1	Homo sapiens	52-58
25286679-8	2014	RT-PCR analysis demonstrated that the expression of Notch1 mRNA decreased significantly in the DAPT groups, with an inhibition rate of 10.23%, 20.50%, and 38.83% for the three DAPT groups, respectively.	dapt	176-180	notch receptor 1	Homo sapiens	52-58
25286679-9	2014	Western blot results demonstrated that the expression of Notch1 protein decreased significantly, with an inhibition rate of 12.89%, 27.47%, and 49.84% for the three DAPT groups, respectively.	dapt	165-169	notch receptor 1	Homo sapiens	57-63
25286679-10	2014	CONCLUSION: Gamma-secretase inhibitor DAPT can block Notch signaling pathway, inhibit proliferation, and induce apoptosis of SKOV3 cells through down-regulation of the expression of Notch1.	dapt	38-42	notch receptor 1	Homo sapiens	53-58
25286679-10	2014	CONCLUSION: Gamma-secretase inhibitor DAPT can block Notch signaling pathway, inhibit proliferation, and induce apoptosis of SKOV3 cells through down-regulation of the expression of Notch1.	dapt	38-42	notch receptor 1	Homo sapiens	182-188
24548083-7	2014	Remarkably, HES5 overexpression efficiently blocked Wnt-3a as well as gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT)-induced neuronal differentiation that was accompanied by a strong MASH1 downregulation thus directly linking HES5 repression/MASH1 induction to the proneurogenic effect of Wnt-3a.	dapt	96-165	hes family bHLH transcription factor 5	Homo sapiens	12-16
24648372-11	2014	gamma-Secretase inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycinet-butyl ester) greatly suppressed the production of NICD and abolished the inhibitory effects of Nap1l1-overexpression on mesoderm induction and cardiogenesis.	dapt	26-30	nucleosome assembly protein 1-like 1	Mus musculus	184-190
24548083-7	2014	Remarkably, HES5 overexpression efficiently blocked Wnt-3a as well as gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT)-induced neuronal differentiation that was accompanied by a strong MASH1 downregulation thus directly linking HES5 repression/MASH1 induction to the proneurogenic effect of Wnt-3a.	dapt	167-171	hes family bHLH transcription factor 5	Homo sapiens	12-16
24793313-0	2014	gamma-secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway.	dapt	26-30	MAPK activated protein kinase 2	Homo sapiens	130-138
24793313-0	2014	gamma-secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway.	dapt	26-30	heat shock protein family B (small) member 1	Homo sapiens	139-144
24793313-9	2014	T-AUCB alone did not significant affect caspase-3 activity in the cells, but t-AUCB plus DAPT pretreatment caused significant increase of caspase-3 activity.	dapt	89-93	caspase 3	Homo sapiens	138-147
24793313-10	2014	Furthermore, pretreatment with DAPT completely blocked t-AUCB-induced phosphorylation of p38 MAPK, MAPKAPK2 and Hsp27 in the cells.	dapt	31-35	MAPK activated protein kinase 2	Homo sapiens	99-107
24793313-10	2014	Furthermore, pretreatment with DAPT completely blocked t-AUCB-induced phosphorylation of p38 MAPK, MAPKAPK2 and Hsp27 in the cells.	dapt	31-35	heat shock protein family B (small) member 1	Homo sapiens	112-117
24793313-11	2014	CONCLUSION: The gamma-secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway, suggesting that the combination of t-AUCB and DAPT may be a potentially effective strategy for the treatment of glioblastoma.	dapt	42-46	MAPK activated protein kinase 2	Homo sapiens	146-154
24793313-11	2014	CONCLUSION: The gamma-secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway, suggesting that the combination of t-AUCB and DAPT may be a potentially effective strategy for the treatment of glioblastoma.	dapt	42-46	heat shock protein family B (small) member 1	Homo sapiens	155-160
24768597-2	2014	In this study we have demonstrated for the first time that inhibitors of SPP, such as L685,458, (Z-LL)2 ketone, aspirin, ibuprofen and DAPT, significantly reduced HSV-1 replication in tissue culture.	dapt	135-139	histocompatibility minor 13	Homo sapiens	73-76
24714800-7	2014	By contrast, blockade of the Notch pathway by DAPT inhibited the TGFbeta2-induced activation of ERK1/2 pathway in LECs.	dapt	46-50	transforming growth factor beta 2	Homo sapiens	65-73
24714800-7	2014	By contrast, blockade of the Notch pathway by DAPT inhibited the TGFbeta2-induced activation of ERK1/2 pathway in LECs.	dapt	46-50	mitogen-activated protein kinase 3	Homo sapiens	96-102
24831762-1	2014	Dual antiplatelet therapy (DAPT) with acetylsalicylic acid and an inhibitor of the adenosine diphosphate platelet receptor P2Y12 has been shown to reduce the risk of stent thrombosis (ST), myocardial infarction and cardiac death after percutaneous coronary intervention (PCI) with bare-metal stents (BMS) and drug-eluting stents (DES).	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	123-128
24932308-8	2014	Using MTT, Transwell and clonality assays, DAPT was found to inhibit the expression of the Notch1 downstream target, Hes1, and impair the ability of the GC cell lines to migrate, invade and proliferate.	dapt	43-47	notch receptor 1	Homo sapiens	91-97
24751889-0	2014	gamma-Secretase inhibitor DAPT attenuates intimal hyperplasia of vein grafts by inhibition of Notch1 signaling.	dapt	26-30	notch receptor 1	Rattus norvegicus	94-100
24751889-2	2014	N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), specific inhibitor of gamma-secretase, has been shown to regulate vSMC proliferation and differentiation through the Notch signaling pathway, but the pathophysiological importance of these findings in venous grafts has not yet been determined.	dapt	72-76	notch receptor 1	Rattus norvegicus	196-201
24751889-7	2014	By blocking the Notch signaling pathway, the gamma-secretase inhibitor DAPT can significantly attenuated intima thickening.	dapt	71-75	notch receptor 1	Rattus norvegicus	16-21
24751889-9	2014	These studies showed that DAPT can restore the vSMC phenotype and inhibit vSMC proliferation through suppression of the Notch1 signaling pathway, and thus opens a new avenue for the treatment of restenosis in vein grafts.	dapt	26-30	notch receptor 1	Rattus norvegicus	120-126
24932308-8	2014	Using MTT, Transwell and clonality assays, DAPT was found to inhibit the expression of the Notch1 downstream target, Hes1, and impair the ability of the GC cell lines to migrate, invade and proliferate.	dapt	43-47	hes family bHLH transcription factor 1	Homo sapiens	117-121
24932308-9	2014	The protein levels of the mesenchymal markers, vimentin, neural cadherin and Snail, were decreased; however, the expression of the epithelial marker, epithelial cadherin, was increased in the GC cell lines treated with DAPT.	dapt	219-223	vimentin	Homo sapiens	47-55
24932308-9	2014	The protein levels of the mesenchymal markers, vimentin, neural cadherin and Snail, were decreased; however, the expression of the epithelial marker, epithelial cadherin, was increased in the GC cell lines treated with DAPT.	dapt	219-223	cadherin 2	Homo sapiens	57-72
24932308-9	2014	The protein levels of the mesenchymal markers, vimentin, neural cadherin and Snail, were decreased; however, the expression of the epithelial marker, epithelial cadherin, was increased in the GC cell lines treated with DAPT.	dapt	219-223	cadherin 2	Homo sapiens	64-72
24932308-11	2014	In conclusion, DAPT inhibits the Notch1 signaling pathway, as well as the growth, invasion, metastasis and EMT of GC cells.	dapt	15-19	notch receptor 1	Homo sapiens	33-39
24573085-8	2014	Inhibition of gamma-secretase by N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) significantly attenuated the Jag-1-induced augmentation of SOCE.	dapt	104-108	jagged canonical Notch ligand 1	Homo sapiens	139-144
24806344-7	2014	In an in vitro IEC-6 culture model, flow cytometry analyses showed that inhibition of Notch signaling by gamma-secretase inhibitor DAPT and the suppression of Hes5 expression using siRNA both significantly increased the apoptosis of IEC-6 cells under the condition of hypoxia/ reoxygenation (H/R).	dapt	131-135	notch receptor 2	Rattus norvegicus	86-91
24788939-7	2014	Finally, we found that blockade of Notch pathway with a specific inhibitor DAPT could inhibit TGFbeta2-induced the activation of ERK1/2 pathway conversely.	dapt	75-79	transforming growth factor beta 2	Homo sapiens	94-102
24788939-7	2014	Finally, we found that blockade of Notch pathway with a specific inhibitor DAPT could inhibit TGFbeta2-induced the activation of ERK1/2 pathway conversely.	dapt	75-79	mitogen-activated protein kinase 3	Homo sapiens	129-135
24791137-15	2014	DAPT effectively blocked the expression of Hes1.	dapt	0-4	transcription factor HES-1	Oryctolagus cuniculus	43-47
24791137-16	2014	DAPT also dose-dependently suppressed Smad7 expression in P0 cells, which was associated with the susceptibility of P0 cells to TGFbeta1-induced Smad2/3 phosphorylation, EMT formation, and growth arrest.	dapt	0-4	mothers against decapentaplegic homolog 7	Oryctolagus cuniculus	38-43
24791137-16	2014	DAPT also dose-dependently suppressed Smad7 expression in P0 cells, which was associated with the susceptibility of P0 cells to TGFbeta1-induced Smad2/3 phosphorylation, EMT formation, and growth arrest.	dapt	0-4	mothers against decapentaplegic homolog 2	Oryctolagus cuniculus	145-152
24705625-6	2014	Moreover, the number of Jagged1-positive cells and percentage of Notch intracellular domain-positive bone marrow cells and protein expression levels of Jagged1 and NICD in bone tissue were also increased in Bmi1-/- mice upon PTH1-34 administration,whereas the up-regulation of PTH on both Notch1 and Jagged1 gene expression was blocked by the Notch inhibitor DAPT administration.	dapt	359-363	Bmi1 polycomb ring finger oncogene	Mus musculus	207-211
24573392-6	2014	In wild-type mice pharmacological inhibition of Notch using the gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) improved tubulo-interstitial damage and antagonized the prosenescent pathway activation after IR.	dapt	90-159	notch 1	Mus musculus	48-53
24573392-6	2014	In wild-type mice pharmacological inhibition of Notch using the gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) improved tubulo-interstitial damage and antagonized the prosenescent pathway activation after IR.	dapt	161-165	notch 1	Mus musculus	48-53
24851694-8	2014	DAPT treatment decreased MPP(+)-induced apoptosis (3.10% +- 0.21% vs 35.50% +- 4.98%, 19.20% +- 2.98%, both P < 0.05) and the expressions of Notch-1, Jagged-1 and Hes-1 in SH-SY5Y cell.	dapt	0-4	notch receptor 1	Homo sapiens	144-151
24851694-8	2014	DAPT treatment decreased MPP(+)-induced apoptosis (3.10% +- 0.21% vs 35.50% +- 4.98%, 19.20% +- 2.98%, both P < 0.05) and the expressions of Notch-1, Jagged-1 and Hes-1 in SH-SY5Y cell.	dapt	0-4	jagged canonical Notch ligand 1	Homo sapiens	153-161
24851694-8	2014	DAPT treatment decreased MPP(+)-induced apoptosis (3.10% +- 0.21% vs 35.50% +- 4.98%, 19.20% +- 2.98%, both P < 0.05) and the expressions of Notch-1, Jagged-1 and Hes-1 in SH-SY5Y cell.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	166-171
24851694-10	2014	DAPT inhibits Notch signaling pathway and protects SH-SY5Y cell from MPP(+)-induced apoptosis.	dapt	0-4	notch receptor 1	Homo sapiens	14-19
24535252-0	2014	Pretreatment with the gamma-secretase inhibitor DAPT sensitizes drug-resistant ovarian cancer cells to cisplatin by downregulation of Notch signaling.	dapt	48-52	notch receptor 1	Homo sapiens	134-139
24492199-4	2014	Notably, DAPT treatment significantly suppressed Th1- and Th17-cell responses in spleen and lymph nodes and reduced IFN-gamma and IL-17 levels in plasma.	dapt	9-13	negative elongation factor complex member C/D, Th1l	Mus musculus	49-52
24492199-4	2014	Notably, DAPT treatment significantly suppressed Th1- and Th17-cell responses in spleen and lymph nodes and reduced IFN-gamma and IL-17 levels in plasma.	dapt	9-13	interferon gamma	Mus musculus	116-125
24492199-4	2014	Notably, DAPT treatment significantly suppressed Th1- and Th17-cell responses in spleen and lymph nodes and reduced IFN-gamma and IL-17 levels in plasma.	dapt	9-13	interleukin 17A	Mus musculus	130-135
24293409-7	2014	Our results suggest that targeting Notch and JAK2/STAT3 signaling pathways simultaneously is superior to single inhibitions, supporting combined treatment by GSI IX and AG-490 as a potential therapeutic approach for PDAC.	dapt	158-164	Janus kinase 2	Homo sapiens	45-49
24293409-7	2014	Our results suggest that targeting Notch and JAK2/STAT3 signaling pathways simultaneously is superior to single inhibitions, supporting combined treatment by GSI IX and AG-490 as a potential therapeutic approach for PDAC.	dapt	158-164	signal transducer and activator of transcription 3	Homo sapiens	50-55
24535252-1	2014	Notch signaling is implicated in ovarian cancer tumorigenesis and inhibition of Notch signaling with gamma-secretase inhibitor DAPT resulted in reduction of tumor cell viability and induction of apoptosis in ovarian cancer cells.	dapt	127-131	notch receptor 1	Homo sapiens	80-85
24535252-8	2014	Pretreatment of ovarian cancer cell lines with DAPT and then with cisplatin downregulated Notch1 and Hes1 expression dose- and time-dependently.	dapt	47-51	notch receptor 1	Homo sapiens	90-96
24535252-8	2014	Pretreatment of ovarian cancer cell lines with DAPT and then with cisplatin downregulated Notch1 and Hes1 expression dose- and time-dependently.	dapt	47-51	hes family bHLH transcription factor 1	Homo sapiens	101-105
24535252-9	2014	The current data demonstrate that DAPT pretreatment was able to sensitize cisplatin-resistant human ovarian cancer cells to cisplatin by downregulation of Notch signaling.	dapt	34-38	notch receptor 1	Homo sapiens	155-160
24493857-9	2014	In combination, these data demonstrate that a single chemical (DAPT) can induce PAX6/RX-positive stem cells to undergo differentiation into functional RGCs.	dapt	63-67	paired box 6	Homo sapiens	80-84
24114531-4	2014	Notch loss-of-function (DAPT and dominant negative [R218H] RBP-Jk [CSL/CBF1]) showed that a functional leptin-Notch signaling axis was involved in the proliferation and migration of E0771 cells.	dapt	24-28	notch receptor 1	Homo sapiens	0-5
24661619-8	2014	Neuroprotection was achieved by N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a Notch activation inhibitor.	dapt	32-101	notch receptor 1	Rattus norvegicus	112-117
24661619-9	2014	DAPT and aspirin given only by regimen 2 and 3 reduced NICD, IL-6 and IL-1beta in the ischemic penumbral cortex.	dapt	0-4	interleukin 6	Rattus norvegicus	61-65
24661619-9	2014	DAPT and aspirin given only by regimen 2 and 3 reduced NICD, IL-6 and IL-1beta in the ischemic penumbral cortex.	dapt	0-4	interleukin 1 beta	Rattus norvegicus	70-78
24430295-3	2014	The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01).	dapt	179-183	notch 1	Mus musculus	33-38
24658363-4	2014	Although most studies show that DAPT inhibits Abeta in a dose-dependent manner several studies have also detected a biphasic effect with an unexpected increase at low doses of DAPT in cell cultures, animal models and clinical trials.	dapt	32-36	amyloid beta precursor protein	Homo sapiens	46-51
24658363-7	2014	Secondly, we have demonstrated that inhibition of an Abeta degrading activity, endothelin converting enzyme (ECE), yielded more Abeta, but abolished the DAPT-induced stimulation.	dapt	153-157	amyloid beta precursor protein	Homo sapiens	53-58
24658363-7	2014	Secondly, we have demonstrated that inhibition of an Abeta degrading activity, endothelin converting enzyme (ECE), yielded more Abeta, but abolished the DAPT-induced stimulation.	dapt	153-157	endothelin converting enzyme 1	Homo sapiens	79-107
24658363-7	2014	Secondly, we have demonstrated that inhibition of an Abeta degrading activity, endothelin converting enzyme (ECE), yielded more Abeta, but abolished the DAPT-induced stimulation.	dapt	153-157	endothelin converting enzyme 1	Homo sapiens	109-112
24368703-6	2014	Following treatment with DAPT, we observed a nearly 50% reduction in the number of surviving Dclk1(+) crypt epithelial cells at 24 h after TBI and similar reduction in the number of surviving small intestinal crypts at 84 h. These data indicate that inhibition of Notch signaling decreases ISC survival following radiation injury, suggesting that the Notch signaling pathway plays an important role in ISC-mediated crypt regeneration.	dapt	25-29	doublecortin like kinase 1	Homo sapiens	93-98
24197755-10	2014	The inhibition of notch signaling activity by DAPT significantly attenuated the isoflurane preconditioning-induced neuroprotection, and similar results were obtained using notch knockout mice.	dapt	46-50	notch 1	Mus musculus	18-23
24430295-3	2014	The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01).	dapt	179-183	notch 1	Mus musculus	48-54
24430295-3	2014	The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01).	dapt	179-183	notch 2	Mus musculus	56-62
24430295-3	2014	The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01).	dapt	179-183	jagged 1	Mus musculus	64-71
24430295-3	2014	The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01).	dapt	179-183	jagged 2	Mus musculus	73-80
24430295-3	2014	The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P < 0.01).	dapt	179-183	hes family bHLH transcription factor 1	Mus musculus	85-89
24430295-4	2014	Since DAPT or L-685,548 inhibits Notch signaling pathway, the expression of protein LHX8 and NOBOX was significantly reduced during the formation of the primordial follicles.	dapt	6-10	notch 1	Mus musculus	33-38
24430295-4	2014	Since DAPT or L-685,548 inhibits Notch signaling pathway, the expression of protein LHX8 and NOBOX was significantly reduced during the formation of the primordial follicles.	dapt	6-10	LIM homeobox protein 8	Mus musculus	84-88
24430295-4	2014	Since DAPT or L-685,548 inhibits Notch signaling pathway, the expression of protein LHX8 and NOBOX was significantly reduced during the formation of the primordial follicles.	dapt	6-10	NOBOX oogenesis homeobox	Mus musculus	93-98
24189144-7	2014	Luciferase reporter analyses suggested basal, canonical Notch activity in SGHPL-5 cells and primary cells that was increased upon seeding on DLL4-coated dishes and diminished in the presence of the Notch/gamma-secretase inhibitors N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester (DAPT) or L-685,458.	dapt	302-306	notch receptor 1	Homo sapiens	56-61
24251351-10	2014	De-differentiation markers, colI, MMP13 and eNOS, were significantly reduced in DAPT-treated chondrocytes and OA cartilage.	dapt	80-84	matrix metallopeptidase 13	Homo sapiens	34-39
24251351-13	2014	DAPT treatment resulted in reduced Jagged1 expression.	dapt	0-4	jagged canonical Notch ligand 1	Homo sapiens	35-42
24251351-14	2014	Notch target gene HES1 increased during chondrocyte culture and was reduced when treated with DAPT.	dapt	94-98	hes family bHLH transcription factor 1	Homo sapiens	18-22
24284009-5	2014	When the NSCs were pre-treated with the Notch pathway inhibitor DAPT, the activation of Notch1 was blocked, lower NSCs differentiation was detected and the neurotrophic effect was also abolished.	dapt	64-68	notch receptor 1	Homo sapiens	40-45
24284009-5	2014	When the NSCs were pre-treated with the Notch pathway inhibitor DAPT, the activation of Notch1 was blocked, lower NSCs differentiation was detected and the neurotrophic effect was also abolished.	dapt	64-68	notch receptor 1	Homo sapiens	88-94
24322887-3	2014	However, several studies have suggested that early discontinuation of dual antiplatelet therapy (DAPT; the combination of aspirin and an inhibitor of platelet P2Y12) is associated with a greater risk for "late" stent thrombosis in patients with DESs.	dapt	97-101	purinergic receptor P2Y12	Homo sapiens	159-164
24322887-8	2014	On the basis of recent clinical studies, a shorter course of DAPT than recommended by the guidelines (at least 12 months in the ACCF/AHA/SCAI guideline and 6-12 months in the European Society of Cardiology guidelines) may be considered, especially with second-generation or newer-generation DESs being associated with a significant reduction in stent thrombosis compared with first-generation DES.	dapt	61-65	suppressor of cancer cell invasion	Homo sapiens	137-141
23881612-6	2014	Treatment of DAPT (a gamma-secretase inhibitor) or TAPI-2 (a hydroxamate-based inhibitor of MMPs, tumor necrosis factor alpha converting enzyme and ADAM17) reduces Notch1 shedding and activation which results in attenuation of stemness genes and CD133.	dapt	13-17	notch receptor 1	Homo sapiens	164-170
23881612-6	2014	Treatment of DAPT (a gamma-secretase inhibitor) or TAPI-2 (a hydroxamate-based inhibitor of MMPs, tumor necrosis factor alpha converting enzyme and ADAM17) reduces Notch1 shedding and activation which results in attenuation of stemness genes and CD133.	dapt	13-17	prominin 1	Homo sapiens	246-251
24398584-7	2014	The increased methylation status of CpG islands within the Stra8 promoter of the oocytes was observed in the presence of DAPT, indicating that Notch signaling is probably necessary for maintaining the epigenetic state of this gene in a way suitable for RA stimulation.	dapt	121-125	stimulated by retinoic acid gene 8	Mus musculus	59-64
24571889-10	2014	The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) can significantly decrease the level of NICD and PARP-1, reduce hippocampal neuronal apoptosis and death, attenuate TNF-alpha release and rescue cognitive impairment caused by CLP.	dapt	101-105	poly (ADP-ribose) polymerase 1	Rattus norvegicus	156-162
24571889-10	2014	The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) can significantly decrease the level of NICD and PARP-1, reduce hippocampal neuronal apoptosis and death, attenuate TNF-alpha release and rescue cognitive impairment caused by CLP.	dapt	101-105	tumor necrosis factor	Rattus norvegicus	223-232
24189144-12	2014	Moreover, DAPT increased markers of differentiated EVT, ie, human leukocyte antigen G1, integrin alpha5, and T-cell factor 4, whereas DLL4 provoked the opposite.	dapt	10-14	integrin subunit alpha 5	Homo sapiens	88-103
24189144-12	2014	Moreover, DAPT increased markers of differentiated EVT, ie, human leukocyte antigen G1, integrin alpha5, and T-cell factor 4, whereas DLL4 provoked the opposite.	dapt	10-14	transcription factor 7 like 2	Homo sapiens	109-124
24583423-7	2014	Logistic and Cox regression analyses showed that a positive iFOBT result was the strongest predictor of the risk of DAPT discontinuation after coronary stenting.	dapt	116-120	cytochrome c oxidase subunit 8A	Homo sapiens	13-16
24088578-1	2014	AIM: Carriers of the reduced-function CYP2C19 allele receiving dual antiplatelet therapy (DAPT) with aspirin and clopidogrel exhibit diminished platelet inhibition and an increased risk of events.	dapt	90-94	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	38-45
23904188-4	2014	We report here that the expression of i21 Flt1 in HUVEC and MDA-MB-231 cells is downregulated by the gamma-secretase inhibitor DAPT.	dapt	127-131	FMS-like tyrosine kinase 1	Mus musculus	42-46
23628311-9	2014	Western blot assay markedly showed that protein levels of CD44-intracellular domain, insulinlike growth factor-1Rbeta, extracellular regulated protein kinase 1/2, cyclin D1, proliferating cell nuclear antigen, and matrix metalloproteinase-9 were downregulated by DAPT, whereas vascular endothelial growth factor receptor-2 and vascular endothelial growth factor-165 were upregulated.	dapt	263-267	proliferating cell nuclear antigen	Homo sapiens	174-240
24386256-9	2013	Notch1 siRNA (in vitro) or DAPT (a known Notch1 inhibitor, in vivo) further enhanced the antitumor activity of SIL, and recombinant Jagged1 protein (a known Notch ligand in vitro) attenuated the antitumor activity of SIL.	dapt	27-31	notch receptor 1	Homo sapiens	41-47
24555978-10	2014	Treatment with DAPT reversed the increase in Hes1, beta-catenin, and pAKT expression and the proportion of CD24(+)CD44(+) cells in gemcitabine-treated cell lines.	dapt	15-19	hes family bHLH transcription factor 1	Homo sapiens	45-49
24555978-10	2014	Treatment with DAPT reversed the increase in Hes1, beta-catenin, and pAKT expression and the proportion of CD24(+)CD44(+) cells in gemcitabine-treated cell lines.	dapt	15-19	catenin beta 1	Homo sapiens	51-63
24555978-10	2014	Treatment with DAPT reversed the increase in Hes1, beta-catenin, and pAKT expression and the proportion of CD24(+)CD44(+) cells in gemcitabine-treated cell lines.	dapt	15-19	CD24 molecule	Homo sapiens	107-111
24555978-10	2014	Treatment with DAPT reversed the increase in Hes1, beta-catenin, and pAKT expression and the proportion of CD24(+)CD44(+) cells in gemcitabine-treated cell lines.	dapt	15-19	CD44 molecule (Indian blood group)	Homo sapiens	114-118
24286423-9	2013	However, myocardial ischemia reperfusion injury was increased in IPost when Notch1 signaling was inhibited using DAPT or with knockdown by Notch1-miRNA.	dapt	113-117	notch receptor 1	Rattus norvegicus	76-82
24041655-8	2013	In contrast, inhibition of Notch by DAPT reduces GUCY1B3 expression and NO-induced cGMP production and VASP phosphorylation in OVCAR3 cells.	dapt	36-40	notch receptor 3	Homo sapiens	27-32
24040853-3	2013	It has been suggested that histamine H2 receptor antagonists (H2RA) can be used as alternatives to PPI to prevent UGIB during DAPT without an increase in the risk of MACE.	dapt	126-130	histamine receptor H2	Homo sapiens	27-48
24041655-8	2013	In contrast, inhibition of Notch by DAPT reduces GUCY1B3 expression and NO-induced cGMP production and VASP phosphorylation in OVCAR3 cells.	dapt	36-40	guanylate cyclase 1 soluble subunit beta 1	Homo sapiens	49-56
24041655-8	2013	In contrast, inhibition of Notch by DAPT reduces GUCY1B3 expression and NO-induced cGMP production and VASP phosphorylation in OVCAR3 cells.	dapt	36-40	vasodilator stimulated phosphoprotein	Homo sapiens	103-107
23989618-9	2013	In postnatal and adult cristae, we found that 5 days of DAPT treatment resulted in a downregulation of the Notch effectors Hes1 and Hes5 and also an increase in the total number of Gfi1(+) hair cells.	dapt	56-60	hes family bHLH transcription factor 1	Homo sapiens	123-127
23989618-9	2013	In postnatal and adult cristae, we found that 5 days of DAPT treatment resulted in a downregulation of the Notch effectors Hes1 and Hes5 and also an increase in the total number of Gfi1(+) hair cells.	dapt	56-60	hes family bHLH transcription factor 5	Homo sapiens	132-136
23989618-9	2013	In postnatal and adult cristae, we found that 5 days of DAPT treatment resulted in a downregulation of the Notch effectors Hes1 and Hes5 and also an increase in the total number of Gfi1(+) hair cells.	dapt	56-60	growth factor independent 1 transcriptional repressor	Homo sapiens	181-185
24520550-7	2013	RESULTS: Administration of DAPT significantly increased serum nitric oxide concentration and reduced vascular endothelial growth factor receptors-1 (VEGFR1) concentration without changes on serum VEGF concentration.	dapt	27-31	FMS-like tyrosine kinase 1	Mus musculus	101-147
24520550-7	2013	RESULTS: Administration of DAPT significantly increased serum nitric oxide concentration and reduced vascular endothelial growth factor receptors-1 (VEGFR1) concentration without changes on serum VEGF concentration.	dapt	27-31	FMS-like tyrosine kinase 1	Mus musculus	149-155
24520550-7	2013	RESULTS: Administration of DAPT significantly increased serum nitric oxide concentration and reduced vascular endothelial growth factor receptors-1 (VEGFR1) concentration without changes on serum VEGF concentration.	dapt	27-31	vascular endothelial growth factor A	Mus musculus	149-153
24223152-5	2013	Chemical inhibition of Notch signaling with N-[N-(3,5-difluorophenacetyl)-1-alany1- S-phenyglycine t-butyl ester (DAPT), a gamma-secretase inhibitor, effectively reduced hypoxia-induced upregulated expression of most inflammatory mediators.	dapt	114-118	notch receptor 1	Rattus norvegicus	23-28
24223152-9	2013	Most interestingly, hypoxia-induced upregulation of NF-kappaB immunoexpression in microglia was prevented when the rats were given DAPT pretreatment underscoring the interrelationship between Notch signaling and NF-kappaB pathways.	dapt	131-135	notch receptor 1	Rattus norvegicus	192-197
23740836-6	2013	Blocking of PS1/gamma-secretase activity by the PS1/gamma-secretase inhibitors and N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, another specific gamma-secretase inhibitor yielded a 100 kDa P-cadherin band on western blots of OSCC cell line extracts.	dapt	83-152	presenilin 1	Homo sapiens	12-15
24046360-8	2013	PRDM14-induced leukemic cells contain high levels of activated NOTCH1 and downstream NOTCH1 targets, including MYC and HES1, and are sensitive to pharmacological inhibition of NOTCH1 with the gamma-secretase inhibitor DAPT.	dapt	218-222	PR domain containing 14	Mus musculus	0-6
22836313-1	2013	The objective of the current study was to investigate the regulation of VEGF signaling and tumor angiogenesis by gamma-secretase inhibitor DAPT in glioblastoma.	dapt	139-143	vascular endothelial growth factor A	Mus musculus	72-76
22836313-3	2013	We found that DAPT efficiently inhibited Notch signaling, increased VEGFR2 expression, but decreased VEGFR1 expression.	dapt	14-18	kinase insert domain protein receptor	Mus musculus	68-74
22836313-3	2013	We found that DAPT efficiently inhibited Notch signaling, increased VEGFR2 expression, but decreased VEGFR1 expression.	dapt	14-18	FMS-like tyrosine kinase 1	Mus musculus	101-107
22836313-4	2013	DAPT treatment enhanced endothelial cell proliferation when used combined with VEGF, but exerted no effect if used alone.	dapt	0-4	vascular endothelial growth factor A	Homo sapiens	79-83
23899513-14	2013	Blocking Notch1 activation by DAPT alone inhibited NIKS cellular proliferation (P < 0.01%).	dapt	30-34	notch receptor 1	Homo sapiens	9-15
24016412-5	2013	Bath application of DAPT or Compound E over the whole recording period of field excitatory postsynaptic potential (fEPSP) caused a reduction of synaptic potentiation within 1h after 3x1s 100Hz/10min stimulation (HFS) of Schaffer-collateral CA1 synapses.	dapt	20-24	carbonic anhydrase 1	Rattus norvegicus	240-243
23161900-4	2013	VEGF/Ang2 induced EC function was assessed using transwell invasion chambers, matrigel tube formation assays and wound repair scratch assays+-Notch-1 siRNA or an gamma-secretase inhibitor N-(N-(3,5-Difluorophenacetyl-L-alanly))-S-phenylglycine-t-Butyl Ester (DAPT) in RA synovial explants or human microvascular EC.	dapt	259-263	vascular endothelial growth factor A	Homo sapiens	0-4
24098462-11	2013	The inhibition of Notch signaling with DAPT and the suppression of Jagged-2 and Hes-1 expression using siRNA both significantly inhibited the proliferation of IEC-6 cells.	dapt	39-43	notch receptor 1	Rattus norvegicus	18-23
22709725-12	2013	The evidence-based use of P2Y12 antagonists in DAPT should further reduce the morbidity and mortality associated with STEMI.	dapt	47-51	purinergic receptor P2Y12	Homo sapiens	26-31
23760446-7	2013	Further, Notch inhibition by systemic treatment with the gamma-secretase inhibitor DAPT, which blocked the proteolytic activation of Notch receptors, reduced the number of CPCs, their proliferative fraction, and cardiomyogenic differentiation in HMGB1-treated infarcted hearts.	dapt	83-87	high mobility group box 1	Mus musculus	246-251
23792588-0	2013	Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/beta-catenin.	dapt	37-41	catenin (cadherin associated protein), beta 1	Mus musculus	117-129
23792588-3	2013	However, activation of extracellular signal-regulated kinase (ERK)1/2 upon DAPT treatment was detected.	dapt	75-79	mitogen-activated protein kinase 3	Mus musculus	23-69
23749167-6	2013	The inhibition of Notch1 or Notch4 with siRNA or the Notch receptor inhibitor DAPT significantly prevented Tbeta4-induced HUVEC tube formation and lymphocyte transendothelial migration.	dapt	78-82	thymosin beta 4 X-linked	Homo sapiens	107-113
22627943-8	2013	DAPT-treated melanomas also exhibited an up-regulation of MMP-2 and VEGFR1, both known as VM mediators.	dapt	0-4	matrix metallopeptidase 2	Mus musculus	58-63
22627943-8	2013	DAPT-treated melanomas also exhibited an up-regulation of MMP-2 and VEGFR1, both known as VM mediators.	dapt	0-4	FMS-like tyrosine kinase 1	Mus musculus	68-74
23699387-8	2013	Apoptotic parameters like PARP and caspase 8 cleavages, BAX, and BCLXs increased in KGN cells cultured with DAPT, whereas others such as BCL2, BCLXl, FAS, and FAS ligand did not change.	dapt	108-112	collagen type XI alpha 2 chain	Homo sapiens	26-30
23699387-8	2013	Apoptotic parameters like PARP and caspase 8 cleavages, BAX, and BCLXs increased in KGN cells cultured with DAPT, whereas others such as BCL2, BCLXl, FAS, and FAS ligand did not change.	dapt	108-112	caspase 8	Homo sapiens	35-44
23699387-8	2013	Apoptotic parameters like PARP and caspase 8 cleavages, BAX, and BCLXs increased in KGN cells cultured with DAPT, whereas others such as BCL2, BCLXl, FAS, and FAS ligand did not change.	dapt	108-112	BCL2 associated X, apoptosis regulator	Homo sapiens	56-59
23161900-4	2013	VEGF/Ang2 induced EC function was assessed using transwell invasion chambers, matrigel tube formation assays and wound repair scratch assays+-Notch-1 siRNA or an gamma-secretase inhibitor N-(N-(3,5-Difluorophenacetyl-L-alanly))-S-phenylglycine-t-Butyl Ester (DAPT) in RA synovial explants or human microvascular EC.	dapt	259-263	angiopoietin 2	Homo sapiens	5-9
23161900-9	2013	Furthermore VEGF/Ang2-induced EC invasion, angiogenesis and migration were inhibited by Notch-1 siRNA or DAPT.	dapt	105-109	vascular endothelial growth factor A	Homo sapiens	12-16
23161900-9	2013	Furthermore VEGF/Ang2-induced EC invasion, angiogenesis and migration were inhibited by Notch-1 siRNA or DAPT.	dapt	105-109	angiopoietin 2	Homo sapiens	17-21
23161900-10	2013	Conditioned media from VEGF/Ang2 stimulated RA synovial explants induced EC tube formation, an effect that was inhibited by DAPT.	dapt	124-128	vascular endothelial growth factor A	Homo sapiens	23-27
23161900-10	2013	Conditioned media from VEGF/Ang2 stimulated RA synovial explants induced EC tube formation, an effect that was inhibited by DAPT.	dapt	124-128	angiopoietin 2	Homo sapiens	28-32
23161900-11	2013	Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants.	dapt	9-13	vascular endothelial growth factor A	Homo sapiens	38-42
23161900-11	2013	Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants.	dapt	9-13	angiopoietin 2	Homo sapiens	43-47
23161900-11	2013	Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants.	dapt	9-13	interleukin 6	Homo sapiens	56-60
23161900-11	2013	Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants.	dapt	9-13	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
23161900-11	2013	Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants.	dapt	9-13	matrix metallopeptidase 2	Homo sapiens	68-72
23557855-3	2013	We further observed the effect of specific inhibitor of PI3K(LY294002) and specific inhibitor of Notch(DAPT) on the proliferation of such CD4(+) T lymphocytes.	dapt	103-107	CD4 antigen	Mus musculus	138-141
23557855-5	2013	Both LY294002 and DAPT inhibit the proliferation of CD4(+) T lymphocytes in a time- and dose-dependent manner.	dapt	18-22	CD4 antigen	Mus musculus	52-55
23557855-6	2013	Furthermore, LY294002 and DAPT have additive effect in down-regulation of cyclinD1 and upregulation of p27kip1.	dapt	26-30	cyclin D1	Mus musculus	74-82
23557855-6	2013	Furthermore, LY294002 and DAPT have additive effect in down-regulation of cyclinD1 and upregulation of p27kip1.	dapt	26-30	cyclin-dependent kinase inhibitor 1B	Mus musculus	103-110
23591351-7	2013	RESULTS: After DAPT was added, Hes1 gene expression level decreased significantly in the cells of passages 4, 8 and 10 as compared with that of the same passage cells in the control group.	dapt	15-19	hes family bHLH transcription factor 1	Homo sapiens	31-35
23704950-8	2013	Moreover, pharmacological inhibition of endogenous Notch-1 signaling by N-3,5-difluorophenyl acetyl-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester (DAPT), a gamma-secretase specific inhibitor, as well as the silencing of Notch-1 ligand, Jagged-1, potentiated TGF-beta1-induced myofibroblast differentiation and abrogated the inhibitory effects of RLX.	dapt	150-154	notch 1	Mus musculus	51-58
23524267-7	2013	Mechanistically, we found that DAPT, a gamma-secretase (a multi-subunit protease complex) inhibitor, reduced the proportion of cell surface Nestin-positive cells in human GSCs in a time- and dose-dependent manner, without significant changes in total Nestin expression, implying that a post-translational modification was involved in the generation of cell surface Nestin.	dapt	31-35	nestin	Homo sapiens	140-146
23524267-7	2013	Mechanistically, we found that DAPT, a gamma-secretase (a multi-subunit protease complex) inhibitor, reduced the proportion of cell surface Nestin-positive cells in human GSCs in a time- and dose-dependent manner, without significant changes in total Nestin expression, implying that a post-translational modification was involved in the generation of cell surface Nestin.	dapt	31-35	nestin	Homo sapiens	251-257
23524267-7	2013	Mechanistically, we found that DAPT, a gamma-secretase (a multi-subunit protease complex) inhibitor, reduced the proportion of cell surface Nestin-positive cells in human GSCs in a time- and dose-dependent manner, without significant changes in total Nestin expression, implying that a post-translational modification was involved in the generation of cell surface Nestin.	dapt	31-35	nestin	Homo sapiens	251-257
23671619-6	2013	DAPT (a gamma secretase inhibitor) and Notch1 siRNA prevented the induction of NICD and Hes1 activation by PTE treatment and sensitized the cells to PTE treatment.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	88-92
23269621-6	2013	VEGF expression was found in the DAPT treated and wild-type embryonic artery, whereas notch target genes GATA4, Hey1 expression were not found in the DAPT treated mice embryo.	dapt	33-37	vascular endothelial growth factor A	Mus musculus	0-4
23219912-5	2013	DAPT and Notch1 siRNA significantly inhibited OSI and the expression of Notch1 and Hes1.	dapt	0-4	notch receptor 1	Homo sapiens	72-78
23578365-8	2013	In vitro, we used gamma-secretase inhibitor N-S-phenyl-glycine-t-butyl ester (DAPT) to block Notch1 signaling in Jurkat cells.	dapt	78-82	notch receptor 1	Homo sapiens	93-99
23578365-15	2013	Blocking Notch1 signal by DAPT inhibited the proliferation of Jurkat cells and induced G0/G1 phase cell cycle arrest and apoptosis.	dapt	26-30	notch receptor 1	Homo sapiens	9-15
23578365-16	2013	Foxp3 as well as p-ERK1/2, STAT1 and NF-kappaB expression was down regulated after DAPT treatment.	dapt	83-87	forkhead box P3	Homo sapiens	0-5
23578365-16	2013	Foxp3 as well as p-ERK1/2, STAT1 and NF-kappaB expression was down regulated after DAPT treatment.	dapt	83-87	mitogen-activated protein kinase 3	Homo sapiens	19-25
23578365-16	2013	Foxp3 as well as p-ERK1/2, STAT1 and NF-kappaB expression was down regulated after DAPT treatment.	dapt	83-87	signal transducer and activator of transcription 1	Homo sapiens	27-32
23578365-16	2013	Foxp3 as well as p-ERK1/2, STAT1 and NF-kappaB expression was down regulated after DAPT treatment.	dapt	83-87	nuclear factor kappa B subunit 1	Homo sapiens	37-46
23219912-5	2013	DAPT and Notch1 siRNA significantly inhibited OSI and the expression of Notch1 and Hes1.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	83-87
23396245-6	2013	DAPT inhibited nuclear-translocation of Olig2, which is indispensable for proliferation and differentiation of reactive astrocytes.	dapt	0-4	oligodendrocyte transcription factor 2	Homo sapiens	40-45
23278106-3	2013	In the majority of CLL cases, DNA-bound NOTCH2 complexes are less sensitive to the gamma-secretase inhibitor (GSI) DAPT.	dapt	115-119	notch receptor 2	Homo sapiens	40-46
23053894-11	2013	DAPT reduced Hes-1 immunostaining in proportion to dose.	dapt	0-4	hes family bHLH transcription factor 1	Rattus norvegicus	13-18
23135908-11	2013	Intratumoral injection of DAPT with cisplatin treatment significantly reduced CD133(+) cell number.	dapt	26-30	prominin 1	Homo sapiens	78-83
23188126-10	2013	All these curative effects were suppressed by pharmacological blockade of Notch signaling with DAPT.	dapt	95-99	notch 1	Mus musculus	74-79
23860246-1	2013	Current guidelines offer a choice of P2Y12 receptor antagonist among clopidogrel, prasugrel or ticagrelor on top of aspirin (ASA) for dual antiplatelet therapy (DAPT) in patients after acute coronary syndromes (ACS).	dapt	161-165	purinergic receptor P2Y12	Homo sapiens	37-42
24107485-1	2013	Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor antagonist is the standard of care in acute coronary syndromes.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	52-57
23171401-0	2013	The gamma-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia.	dapt	28-32	occludin	Rattus norvegicus	137-145
23171401-8	2013	Furthermore, our data demonstrate that the inhibition of gamma-secretase signaling and the itch-mediated ubiquitination of occludin likely underlie the vasoprotective effect of DAPT after pMCAO.	dapt	177-181	itchy E3 ubiquitin protein ligase	Rattus norvegicus	91-95
23171401-8	2013	Furthermore, our data demonstrate that the inhibition of gamma-secretase signaling and the itch-mediated ubiquitination of occludin likely underlie the vasoprotective effect of DAPT after pMCAO.	dapt	177-181	occludin	Rattus norvegicus	123-131
23171401-9	2013	CONCLUSION: The gamma-secretase blocker DAPT reduces the permeability of the BBB by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia, suggesting that gamma-secretase may represent a novel therapeutic target for preventing neurovascular damage.	dapt	40-44	occludin	Rattus norvegicus	133-141
23489689-4	2013	The results showed that Jagged-1 could promote the expression of Hes-1 and Deltex-1 mRNAs and the expression of NICD, Hes-1 and Deltex-1 proteins, which might be significantly blocked by DAPT, a specific inhibitor of Notch signaling.	dapt	187-191	jagged canonical Notch ligand 1	Homo sapiens	24-32
23489689-4	2013	The results showed that Jagged-1 could promote the expression of Hes-1 and Deltex-1 mRNAs and the expression of NICD, Hes-1 and Deltex-1 proteins, which might be significantly blocked by DAPT, a specific inhibitor of Notch signaling.	dapt	187-191	hes family bHLH transcription factor 1	Homo sapiens	65-70
23489689-4	2013	The results showed that Jagged-1 could promote the expression of Hes-1 and Deltex-1 mRNAs and the expression of NICD, Hes-1 and Deltex-1 proteins, which might be significantly blocked by DAPT, a specific inhibitor of Notch signaling.	dapt	187-191	deltex E3 ubiquitin ligase 1	Homo sapiens	75-83
23489689-4	2013	The results showed that Jagged-1 could promote the expression of Hes-1 and Deltex-1 mRNAs and the expression of NICD, Hes-1 and Deltex-1 proteins, which might be significantly blocked by DAPT, a specific inhibitor of Notch signaling.	dapt	187-191	hes family bHLH transcription factor 1	Homo sapiens	118-123
23489689-4	2013	The results showed that Jagged-1 could promote the expression of Hes-1 and Deltex-1 mRNAs and the expression of NICD, Hes-1 and Deltex-1 proteins, which might be significantly blocked by DAPT, a specific inhibitor of Notch signaling.	dapt	187-191	deltex E3 ubiquitin ligase 1	Homo sapiens	128-136
23489689-7	2013	The level of IL-10 produced by the treated cells was also enhanced, whereas the expression of IL-17 was prominently attenuated, which could be offset by anti-Jagged-1 antibody or DAPT.	dapt	179-183	interleukin 17A	Homo sapiens	94-99
26835278-8	2013	DAPT treatment did not alter the levels of Notch 1 to 4 receptor but remarkably decreased HERP1 and HERP2 mRNA expression (P<0.05).	dapt	0-4	hes-related family bHLH transcription factor with YRPW motif 2	Rattus norvegicus	90-95
23691527-6	2013	Notch pathway-related molecules, TGF- beta , and fibronectin increased with exposure to high glucose and decreased with DAPT treatment.	dapt	120-124	fibronectin 1	Rattus norvegicus	49-60
23372773-5	2013	Treatment of both mouse and human neurospheres with the gamma-secretase inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) reduced expression of the transcription factors Hes1 and Hes5, demonstrating inhibition of Notch signaling.	dapt	82-151	hes family bHLH transcription factor 1	Homo sapiens	207-211
23372773-5	2013	Treatment of both mouse and human neurospheres with the gamma-secretase inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) reduced expression of the transcription factors Hes1 and Hes5, demonstrating inhibition of Notch signaling.	dapt	82-151	hes family bHLH transcription factor 5	Homo sapiens	216-220
23308095-2	2013	We describe how different drug-candidates can modulate gamma-secretase activity in cells, by studying how DAPT affects changes in gamma-secretase activity caused by gradual increase in Abeta metabolism.	dapt	106-110	amyloid beta precursor protein	Homo sapiens	185-190
26835278-8	2013	DAPT treatment did not alter the levels of Notch 1 to 4 receptor but remarkably decreased HERP1 and HERP2 mRNA expression (P<0.05).	dapt	0-4	hes-related family bHLH transcription factor with YRPW motif 1	Rattus norvegicus	100-105
26835278-9	2013	DAPT treatment also decreased angiotensin II-induced vascular medial thickness and PCNA positive cell rate, and increased caspase-3 positive cell rate (P<0.05).	dapt	0-4	angiotensinogen	Rattus norvegicus	30-44
26835278-9	2013	DAPT treatment also decreased angiotensin II-induced vascular medial thickness and PCNA positive cell rate, and increased caspase-3 positive cell rate (P<0.05).	dapt	0-4	proliferating cell nuclear antigen	Rattus norvegicus	83-87
26835278-9	2013	DAPT treatment also decreased angiotensin II-induced vascular medial thickness and PCNA positive cell rate, and increased caspase-3 positive cell rate (P<0.05).	dapt	0-4	caspase 3	Rattus norvegicus	122-131
23147438-1	2012	The concomitant use of aspirin and an ADP receptor (P2Y12) blocker, also known as dual antiplatelet therapy (DAPT), has been extensively investigated as a primary and secondary prevention strategy in an effort to reduce the risk of cardiovascular events.	dapt	109-113	purinergic receptor P2Y12	Homo sapiens	52-57
22302604-0	2012	DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor kappaB in rats.	dapt	0-4	notch receptor 1	Rattus norvegicus	83-90
22302604-1	2012	Gamma-secretase inhibitor, N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) suppresses the activation of Notch 1 signaling, which is recognized as the cell fate signaling and may participate in inflammatory processes together with NF-kappaB pathway that contributes to the brain damage after stroke.	dapt	98-102	notch receptor 1	Rattus norvegicus	133-140
22302604-4	2012	This study investigated the time course expression of Notch 1 and the effects of DAPT on Notch 1 and NF-jB after MCAO.	dapt	81-85	notch receptor 1	Rattus norvegicus	89-96
22302604-5	2012	The results showed that Notch 1 signaling was up-regulated at the early stage after MCAO, DAPT down-regulated the expression of Notch 1 and NF-kappaB and protected brain from damage caused by MCAO.	dapt	90-94	notch receptor 1	Rattus norvegicus	24-31
22302604-5	2012	The results showed that Notch 1 signaling was up-regulated at the early stage after MCAO, DAPT down-regulated the expression of Notch 1 and NF-kappaB and protected brain from damage caused by MCAO.	dapt	90-94	notch receptor 1	Rattus norvegicus	128-135
22302604-6	2012	These results may indicate that the downregulation of Notch 1-NF-kappaB pathway after ischemia by administration of DAPT is a potential mechanism for its protection.	dapt	116-120	notch receptor 1	Rattus norvegicus	54-61
22642687-6	2012	The inhibition of beta-catenin signaling by XAV and NOTCH signaling by DAPT reversed CHIR impact on hiPSC-NPs proliferation.	dapt	71-75	catenin beta 1	Homo sapiens	18-30
22809957-4	2012	Conversely, IL-33 expression was inhibited by the gamma-secretase inhibitor DAPT or by inhibiting the function of Dll4, Jagged1, Notch1, or the canonical Notch transcription factor RBP-Jkappa.	dapt	76-80	interleukin 33	Homo sapiens	12-17
22981606-6	2012	Attenuation of Notch signaling activity by DAPT or by morpholino knockdown of Notch1a is sufficient to rescue both the proliferative and differentiation defects in Id2a-deficient retinae.	dapt	43-47	inhibitor of DNA binding 2a	Danio rerio	164-168
22973011-7	2012	Treatment of explants with a gamma-secretase inhibitor, DAPT, decreased Fgf20 mRNA, suggesting that Notch is upstream of Fgf20.	dapt	56-60	fibroblast growth factor 20	Homo sapiens	72-77
22973011-7	2012	Treatment of explants with a gamma-secretase inhibitor, DAPT, decreased Fgf20 mRNA, suggesting that Notch is upstream of Fgf20.	dapt	56-60	fibroblast growth factor 20	Homo sapiens	121-126
22809957-6	2012	The in vivo expression of Dll4 but not of Jagged1 was well correlated with expression of IL-33 in quiescent vessels, and subcutaneous injection of DAPT in healthy skin reduced IL-33 expression, indicating that Notch signaling was involved.	dapt	147-151	interleukin 33	Homo sapiens	176-181
22809957-6	2012	The in vivo expression of Dll4 but not of Jagged1 was well correlated with expression of IL-33 in quiescent vessels, and subcutaneous injection of DAPT in healthy skin reduced IL-33 expression, indicating that Notch signaling was involved.	dapt	147-151	notch receptor 1	Homo sapiens	210-215
22525134-6	2012	The increase in cell proliferation induced by hypoxia was greatly attenuated by blocking Notch signaling with the inhibitor DAPT, resulting in the reduced expression of positive cell-cycle regulators (cyclins A and D1) and neural and retinal progenitor markers (Notch1, Hes1, Sox2, Pax6, and NeuroD1).	dapt	124-128	notch receptor 1	Rattus norvegicus	89-94
22290418-7	2012	We show that NICD transduction modulates known direct and indirect Notch target genes and antagonizes the DAPT-mediated inhibition of Notch signaling on the transcriptional level.	dapt	106-110	notch receptor 1	Homo sapiens	134-139
22931655-5	2012	The expressions of Notch1 and Hes1 proteins were gradually downregulated with the increase of DAPT concentration.	dapt	94-98	notch receptor 1	Homo sapiens	19-25
22931655-5	2012	The expressions of Notch1 and Hes1 proteins were gradually downregulated with the increase of DAPT concentration.	dapt	94-98	hes family bHLH transcription factor 1	Homo sapiens	30-34
22931655-6	2012	It is concluded that the DAPT can inhibit the proliferation of RPMI8226 cells, which may be related with the down-regulation of the protein expression of Notchl and Hes1.	dapt	25-29	hes family bHLH transcription factor 1	Homo sapiens	165-169
22863581-7	2012	The expression of Hes-1 in CD34(+); cells also  increased,  but there was no obvious change after DAPT (50 nmol/L) was added in co-culture medium.	dapt	98-102	hes family bHLH transcription factor 1	Homo sapiens	18-23
22525134-6	2012	The increase in cell proliferation induced by hypoxia was greatly attenuated by blocking Notch signaling with the inhibitor DAPT, resulting in the reduced expression of positive cell-cycle regulators (cyclins A and D1) and neural and retinal progenitor markers (Notch1, Hes1, Sox2, Pax6, and NeuroD1).	dapt	124-128	cyclin D1	Rattus norvegicus	201-217
22525134-6	2012	The increase in cell proliferation induced by hypoxia was greatly attenuated by blocking Notch signaling with the inhibitor DAPT, resulting in the reduced expression of positive cell-cycle regulators (cyclins A and D1) and neural and retinal progenitor markers (Notch1, Hes1, Sox2, Pax6, and NeuroD1).	dapt	124-128	notch receptor 1	Rattus norvegicus	262-268
22525134-6	2012	The increase in cell proliferation induced by hypoxia was greatly attenuated by blocking Notch signaling with the inhibitor DAPT, resulting in the reduced expression of positive cell-cycle regulators (cyclins A and D1) and neural and retinal progenitor markers (Notch1, Hes1, Sox2, Pax6, and NeuroD1).	dapt	124-128	hes family bHLH transcription factor 1	Rattus norvegicus	270-274
22525134-6	2012	The increase in cell proliferation induced by hypoxia was greatly attenuated by blocking Notch signaling with the inhibitor DAPT, resulting in the reduced expression of positive cell-cycle regulators (cyclins A and D1) and neural and retinal progenitor markers (Notch1, Hes1, Sox2, Pax6, and NeuroD1).	dapt	124-128	SRY-box transcription factor 2	Rattus norvegicus	276-280
22525134-6	2012	The increase in cell proliferation induced by hypoxia was greatly attenuated by blocking Notch signaling with the inhibitor DAPT, resulting in the reduced expression of positive cell-cycle regulators (cyclins A and D1) and neural and retinal progenitor markers (Notch1, Hes1, Sox2, Pax6, and NeuroD1).	dapt	124-128	paired box 6	Rattus norvegicus	282-286
22525134-6	2012	The increase in cell proliferation induced by hypoxia was greatly attenuated by blocking Notch signaling with the inhibitor DAPT, resulting in the reduced expression of positive cell-cycle regulators (cyclins A and D1) and neural and retinal progenitor markers (Notch1, Hes1, Sox2, Pax6, and NeuroD1).	dapt	124-128	neuronal differentiation 1	Rattus norvegicus	292-299
22525134-7	2012	Blockade of the Notch signaling pathway by DAPT after hypoxia promoted the differentiation of rMC-1 cells to neurons, as demonstrated by the induction of neural marker (Tuj1), retinal amacrine (Syntaxin1), and retinal ganglion cell (Brn3b) markers, although the expression of the latter marker was low.	dapt	43-47	notch receptor 1	Rattus norvegicus	16-21
22525134-7	2012	Blockade of the Notch signaling pathway by DAPT after hypoxia promoted the differentiation of rMC-1 cells to neurons, as demonstrated by the induction of neural marker (Tuj1), retinal amacrine (Syntaxin1), and retinal ganglion cell (Brn3b) markers, although the expression of the latter marker was low.	dapt	43-47	POU class 4 homeobox 2	Rattus norvegicus	233-238
22275240-10	2012	Finally, 3% hypoxia-induced angiogenesis, endothelial cell migration, endothelial cell invasion, and proMMP-2 and proMMP-9 activities were inhibited by Notch-1 siRNA and/or the gamma-secretase inhibitor DAPT.	dapt	203-207	notch receptor 1	Homo sapiens	152-159
22534476-10	2012	DAPT treatment also hampered the secretion of CCL19 (but not of IL-6) by cDC(LPS) conditioned pDCs.	dapt	0-4	C-C motif chemokine ligand 19	Homo sapiens	46-51
21723221-8	2011	RESULTS: Wild-type mice were more susceptible to CAC following inhibition of Notch1 by DAPT, shown by increased numbers of tumors and level of dysplasia compared with controls.	dapt	87-91	notch 1	Mus musculus	77-83
22445932-8	2012	Our results demonstrate that both local and systemic modulation of gamma-secretase hyper-activity with DAPT increase the duration of TNF-alpha, COX-II, and NFkappaB induction.	dapt	103-107	tumor necrosis factor	Rattus norvegicus	133-142
22445932-8	2012	Our results demonstrate that both local and systemic modulation of gamma-secretase hyper-activity with DAPT increase the duration of TNF-alpha, COX-II, and NFkappaB induction.	dapt	103-107	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	144-150
22391171-10	2012	The activity of Notch pathway could be inhibited by DAPT treatment through down-regulating the expression of Notch target gene Hes1.	dapt	52-56	hes family bHLH transcription factor 1	Homo sapiens	127-131
22108007-9	2012	The potential role of Abeta in autophagic activation was determined with N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	145-149	amyloid beta precursor protein	Homo sapiens	22-27
23094026-7	2012	Furthermore, under GSI IX treatment, decline in the growth of pancreatic tumor initiating CD44+/EpCAM+ cells was observed in vitro and in a xenograft mouse model.	dapt	19-25	CD44 antigen	Mus musculus	90-94
22332538-5	2011	The alterations of Notch 1 to 4 receptor and HERP1, 2 mRNA were discerned by FQ-PCR to observe the influence of DAPT on Notch signal.	dapt	112-116	notch receptor 1	Rattus norvegicus	120-125
22332538-8	2011	When DAPT were added to inhibit Notch signaling, the expression of HERP1, 2 mRNA decreased, the degrees of PDGF induced vascular medial thickness and PCNA positive cell rate increase as well as caspase-3 positive cell rate decrease were all attenuated notably.	dapt	5-9	notch receptor 1	Rattus norvegicus	32-37
22332538-8	2011	When DAPT were added to inhibit Notch signaling, the expression of HERP1, 2 mRNA decreased, the degrees of PDGF induced vascular medial thickness and PCNA positive cell rate increase as well as caspase-3 positive cell rate decrease were all attenuated notably.	dapt	5-9	hes-related family bHLH transcription factor with YRPW motif 2	Rattus norvegicus	67-72
22332538-8	2011	When DAPT were added to inhibit Notch signaling, the expression of HERP1, 2 mRNA decreased, the degrees of PDGF induced vascular medial thickness and PCNA positive cell rate increase as well as caspase-3 positive cell rate decrease were all attenuated notably.	dapt	5-9	proliferating cell nuclear antigen	Rattus norvegicus	150-154
22332538-8	2011	When DAPT were added to inhibit Notch signaling, the expression of HERP1, 2 mRNA decreased, the degrees of PDGF induced vascular medial thickness and PCNA positive cell rate increase as well as caspase-3 positive cell rate decrease were all attenuated notably.	dapt	5-9	caspase 3	Rattus norvegicus	194-203
22583596-11	2012	Inhibition of Notch1 using pooled siRNA or DAPT abrogated the inhibition of ROCK1 by MS-275.	dapt	43-47	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	76-81
22190977-4	2012	Blockage of Notch signaling by a gamma-secretase inhibitor (DAPT) inhibited IL-6 secretion of RA FLSs in response to TNF-alpha while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response.	dapt	60-64	notch receptor 2	Homo sapiens	12-17
22190977-4	2012	Blockage of Notch signaling by a gamma-secretase inhibitor (DAPT) inhibited IL-6 secretion of RA FLSs in response to TNF-alpha while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response.	dapt	60-64	interleukin 6	Homo sapiens	76-80
22190977-4	2012	Blockage of Notch signaling by a gamma-secretase inhibitor (DAPT) inhibited IL-6 secretion of RA FLSs in response to TNF-alpha while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response.	dapt	60-64	tumor necrosis factor	Homo sapiens	117-126
23056328-4	2012	Blocking Notch signaling activation by a gamma-secretase inhibitor, DAPT, significantly attenuated liver fibrosis and decreased the expression of snail, vimentin, and TGF-beta1 in association with the enhanced expression of E-cadherin.	dapt	68-72	notch receptor 3	Rattus norvegicus	9-14
23056328-4	2012	Blocking Notch signaling activation by a gamma-secretase inhibitor, DAPT, significantly attenuated liver fibrosis and decreased the expression of snail, vimentin, and TGF-beta1 in association with the enhanced expression of E-cadherin.	dapt	68-72	vimentin	Rattus norvegicus	153-161
23056328-4	2012	Blocking Notch signaling activation by a gamma-secretase inhibitor, DAPT, significantly attenuated liver fibrosis and decreased the expression of snail, vimentin, and TGF-beta1 in association with the enhanced expression of E-cadherin.	dapt	68-72	transforming growth factor, beta 1	Rattus norvegicus	167-176
23056328-4	2012	Blocking Notch signaling activation by a gamma-secretase inhibitor, DAPT, significantly attenuated liver fibrosis and decreased the expression of snail, vimentin, and TGF-beta1 in association with the enhanced expression of E-cadherin.	dapt	68-72	cadherin 1	Rattus norvegicus	224-234
23028940-7	2012	Inhibition of endothelial cell growth and sprouting angiogenesis by DLL4/Notch signaling was enhanced in SIRT1-silenced lung cancer-derived EC and rescued by Notch inhibitor DAPT.	dapt	174-178	delta like canonical Notch ligand 4	Mus musculus	68-72
23028940-7	2012	Inhibition of endothelial cell growth and sprouting angiogenesis by DLL4/Notch signaling was enhanced in SIRT1-silenced lung cancer-derived EC and rescued by Notch inhibitor DAPT.	dapt	174-178	notch 1	Mus musculus	73-78
23028940-7	2012	Inhibition of endothelial cell growth and sprouting angiogenesis by DLL4/Notch signaling was enhanced in SIRT1-silenced lung cancer-derived EC and rescued by Notch inhibitor DAPT.	dapt	174-178	notch 1	Mus musculus	158-163
22031879-5	2011	Treatment with DAPT, an inhibitor of gamma-secretase, reduced notch pathway activity, enhanced Atoh1 transcriptional activity, and dramatically increased the number of Atoh1-expressing cells with hair cell features, but only in the striolar/juxtastriolar region.	dapt	15-19	atonal bHLH transcription factor 1	Mus musculus	95-100
22031879-5	2011	Treatment with DAPT, an inhibitor of gamma-secretase, reduced notch pathway activity, enhanced Atoh1 transcriptional activity, and dramatically increased the number of Atoh1-expressing cells with hair cell features, but only in the striolar/juxtastriolar region.	dapt	15-19	atonal bHLH transcription factor 1	Mus musculus	168-173
21929751-10	2011	Lastly, DAPT-mediated inhibition of Notch-1 resulted in HCT116 tumor growth arrest and down regulation of Notch-1 via a miR-144 dependent mechanism.	dapt	8-12	notch receptor 1	Homo sapiens	36-43
21929751-10	2011	Lastly, DAPT-mediated inhibition of Notch-1 resulted in HCT116 tumor growth arrest and down regulation of Notch-1 via a miR-144 dependent mechanism.	dapt	8-12	notch receptor 1	Homo sapiens	106-113
21929751-10	2011	Lastly, DAPT-mediated inhibition of Notch-1 resulted in HCT116 tumor growth arrest and down regulation of Notch-1 via a miR-144 dependent mechanism.	dapt	8-12	microRNA 144	Homo sapiens	120-127
21876634-6	2011	Furthermore, blocking Notch-1 activation with a gamma-secretase inhibitor, DAPT, downregulated LSF expression in HepG2 cells.	dapt	75-79	notch receptor 1	Homo sapiens	22-29
21880906-6	2011	Exposure of cells to the gamma-secretase inhibitor-DAPT or silencing of Notch1 resulted in abrogation of cocaine-mediated induction of PDGF-B.	dapt	51-55	platelet derived growth factor subunit B	Homo sapiens	135-141
21880906-11	2011	Specificity of Notch1 signaling in vivo was validated in mice exposed to DAPT, which failed to demonstrate barrier disruption following cocaine exposure.	dapt	73-77	notch 1	Mus musculus	15-21
21843347-9	2011	Disruption of Notch signaling by DAPT attenuated the LPS-induced inflammatory responses, including vascular endothelial growth factor (VEGF) and high-mobility group box chromosomal protein 1 (HMGB1), both in vitro and in vivo and partially improved experimental sepsis survival.	dapt	33-37	vascular endothelial growth factor A	Mus musculus	99-133
21832199-3	2011	The neuronal morphological effects found in p50(-/-) cortical cells were reversed after treatment with the gamma-secretase inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-1-alanyl 1]-S-phenylglycine t-butyl ester) or Notch RNA interference.	dapt	133-137	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-47
21876634-6	2011	Furthermore, blocking Notch-1 activation with a gamma-secretase inhibitor, DAPT, downregulated LSF expression in HepG2 cells.	dapt	75-79	transcription factor CP2	Homo sapiens	95-98
22093939-10	2011	RESULTS: PTHrP (1 - 34) and Jagged1/Fc could dramatically elevate the rate of epiphysis stem cells zone by the whole growth plate length measurement while PTHrP (7 - 34) and DAPT could decrease the rate.	dapt	174-178	jagged canonical Notch ligand 1	Rattus norvegicus	28-35
21622856-4	2011	Treatment with gamma-secretase inhibitors L-685,458 or DAPT or introduction of small interfering RNA directed against Notch1 reduced EGF-induced MUC5AC expression.	dapt	55-59	epidermal growth factor	Homo sapiens	133-136
22977566-6	2011	We found that the gamma-secretase inhibitor DAPT increased protein and mRNA expression of VEGFR-2 and eNOS, but decreased VEGFR-1 expression and had no significant effect on VEGFR-3.	dapt	44-48	kinase insert domain protein receptor	Mus musculus	90-97
22977566-6	2011	We found that the gamma-secretase inhibitor DAPT increased protein and mRNA expression of VEGFR-2 and eNOS, but decreased VEGFR-1 expression and had no significant effect on VEGFR-3.	dapt	44-48	nitric oxide synthase 3, endothelial cell	Mus musculus	102-106
22977566-6	2011	We found that the gamma-secretase inhibitor DAPT increased protein and mRNA expression of VEGFR-2 and eNOS, but decreased VEGFR-1 expression and had no significant effect on VEGFR-3.	dapt	44-48	FMS-like tyrosine kinase 1	Mus musculus	122-129
21622856-4	2011	Treatment with gamma-secretase inhibitors L-685,458 or DAPT or introduction of small interfering RNA directed against Notch1 reduced EGF-induced MUC5AC expression.	dapt	55-59	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	145-151
21373759-5	2011	The ability of the PS-1 substrate-competitor DAPT to induce MAO-A activity in cells expressing either PS-1 wildtype or PS-1(M146V) suggests the potential for a direct influence of PS-1 on MAO-A function.	dapt	45-49	presenilin 1	Homo sapiens	19-23
21373759-5	2011	The ability of the PS-1 substrate-competitor DAPT to induce MAO-A activity in cells expressing either PS-1 wildtype or PS-1(M146V) suggests the potential for a direct influence of PS-1 on MAO-A function.	dapt	45-49	monoamine oxidase A	Homo sapiens	60-65
21373759-5	2011	The ability of the PS-1 substrate-competitor DAPT to induce MAO-A activity in cells expressing either PS-1 wildtype or PS-1(M146V) suggests the potential for a direct influence of PS-1 on MAO-A function.	dapt	45-49	presenilin 1	Homo sapiens	102-106
21373759-5	2011	The ability of the PS-1 substrate-competitor DAPT to induce MAO-A activity in cells expressing either PS-1 wildtype or PS-1(M146V) suggests the potential for a direct influence of PS-1 on MAO-A function.	dapt	45-49	presenilin 1	Homo sapiens	102-106
21373759-5	2011	The ability of the PS-1 substrate-competitor DAPT to induce MAO-A activity in cells expressing either PS-1 wildtype or PS-1(M146V) suggests the potential for a direct influence of PS-1 on MAO-A function.	dapt	45-49	presenilin 1	Homo sapiens	102-106
21373759-5	2011	The ability of the PS-1 substrate-competitor DAPT to induce MAO-A activity in cells expressing either PS-1 wildtype or PS-1(M146V) suggests the potential for a direct influence of PS-1 on MAO-A function.	dapt	45-49	monoamine oxidase A	Homo sapiens	188-193
21427220-6	2011	L-658,458 and DAPT treatment inhibited proliferation of in vitro cultured primary granulosa cells and decreased the expression of c-Myc.	dapt	14-18	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	130-135
21665937-6	2011	231-BR cells with a CD44(hi)/CD24(lo) phenotype was reduced by about 15% in cells treated with DAPT compared with DMSO-treated or untreated cells (P = 0.001, ANOVA).	dapt	95-99	CD44 antigen	Mus musculus	20-24
21665937-6	2011	231-BR cells with a CD44(hi)/CD24(lo) phenotype was reduced by about 15% in cells treated with DAPT compared with DMSO-treated or untreated cells (P = 0.001, ANOVA).	dapt	95-99	CD24a antigen	Mus musculus	29-33
21572390-3	2011	When co-cultured with BMSCs in vitro, HPCs differentiation towards B lymphocytes is significantly compromised on MT1-MMP-deficient BMSCs and this defect could be completely rescued by DAPT, a specific Notch signalling inhibitor.	dapt	184-188	matrix metallopeptidase 14	Homo sapiens	113-120
21427220-7	2011	Lentivirus mediated overexpression of Notch intracellular domain 2, and c-Myc could promote the proliferation of granulosa cells and rescue the growth inhibition induced by L-658,458 and DAPT.	dapt	187-191	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	72-77
21209419-9	2011	The local intrabursal administration of DAPT decreased serum P(4) levels and increased luteal levels of active caspase 3 and the BAX:BCL2 ratio 24 h after the treatment.	dapt	40-44	caspase 3	Rattus norvegicus	111-120
21672428-8	2011	DAPT treatment did not result in the alterations of Notch 1 to 4 receptor levels, but decreased remarkably HERP1 and HERP2 mRNA expression.	dapt	0-4	hes-related family bHLH transcription factor with YRPW motif 2	Rattus norvegicus	107-112
21672428-8	2011	DAPT treatment did not result in the alterations of Notch 1 to 4 receptor levels, but decreased remarkably HERP1 and HERP2 mRNA expression.	dapt	0-4	hes-related family bHLH transcription factor with YRPW motif 1	Rattus norvegicus	117-122
21672428-9	2011	DAPT treatment also decreased angiotensin II-induced vascular medial thickness and PCNA positive cell rate and increased caspase-3 positive cell rate.	dapt	0-4	angiotensinogen	Rattus norvegicus	30-44
21672428-9	2011	DAPT treatment also decreased angiotensin II-induced vascular medial thickness and PCNA positive cell rate and increased caspase-3 positive cell rate.	dapt	0-4	proliferating cell nuclear antigen	Rattus norvegicus	83-87
21672428-9	2011	DAPT treatment also decreased angiotensin II-induced vascular medial thickness and PCNA positive cell rate and increased caspase-3 positive cell rate.	dapt	0-4	caspase 3	Rattus norvegicus	121-130
21398698-8	2011	DDR1 activation suppressed genotoxic-mediated cell death, whereas Notch1 inhibition by a gamma-secretase inhibitor, DAPT, enhanced cell death in response to stress.	dapt	116-120	notch receptor 1	Homo sapiens	66-72
21312186-5	2011	In the mouse model of bleomycin-induced dermal fibrosis and in tight skin 1 mice, Notch signaling was inhibited by the gamma-secretase inhibitor DAPT and by overexpression of a Notch-1 antisense construct.	dapt	145-149	notch 1	Mus musculus	82-87
21209419-9	2011	The local intrabursal administration of DAPT decreased serum P(4) levels and increased luteal levels of active caspase 3 and the BAX:BCL2 ratio 24 h after the treatment.	dapt	40-44	BCL2 associated X, apoptosis regulator	Rattus norvegicus	129-132
21209419-9	2011	The local intrabursal administration of DAPT decreased serum P(4) levels and increased luteal levels of active caspase 3 and the BAX:BCL2 ratio 24 h after the treatment.	dapt	40-44	BCL2, apoptosis regulator	Rattus norvegicus	133-137
21235539-10	2011	Inhibition of Notch signalling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) and Notch3 antibody decreased the collagen-specific T cell proliferation and attenuated Th1- and Th17-type responses, while treatment with Notch ligand Delta-like 1 promoted such a response.	dapt	34-103	notch 3	Mus musculus	14-19
21466361-8	2011	Inhibition of Notch signaling with gamma-secretase inhibitors, L-685,458 and DAPT, prevented Hes1 nuclear translocation but neither suppressed growth nor induced cell death.	dapt	77-81	notch receptor 1	Homo sapiens	14-19
21466361-8	2011	Inhibition of Notch signaling with gamma-secretase inhibitors, L-685,458 and DAPT, prevented Hes1 nuclear translocation but neither suppressed growth nor induced cell death.	dapt	77-81	hes family bHLH transcription factor 1	Homo sapiens	93-97
21235539-10	2011	Inhibition of Notch signalling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) and Notch3 antibody decreased the collagen-specific T cell proliferation and attenuated Th1- and Th17-type responses, while treatment with Notch ligand Delta-like 1 promoted such a response.	dapt	105-109	notch 3	Mus musculus	14-19
21212269-9	2011	In addition, Dll4 expression by the GSK3beta inhibitor was only observed in confluent cells, and was impeded by DAPT, a gamma-secretase inhibitor, implying requirement of the Notch signal in beta-catenin-dependent Dll4 expression.	dapt	112-116	delta like canonical Notch ligand 4	Homo sapiens	13-17
21448337-7	2011	Notch signaling inhibitor DAPT significantly attenuated Numb siRNA-augmented apoptosis.	dapt	26-30	notch receptor 1	Rattus norvegicus	0-5
21448337-7	2011	Notch signaling inhibitor DAPT significantly attenuated Numb siRNA-augmented apoptosis.	dapt	26-30	NUMB, endocytic adaptor protein	Rattus norvegicus	56-60
21212269-9	2011	In addition, Dll4 expression by the GSK3beta inhibitor was only observed in confluent cells, and was impeded by DAPT, a gamma-secretase inhibitor, implying requirement of the Notch signal in beta-catenin-dependent Dll4 expression.	dapt	112-116	glycogen synthase kinase 3 beta	Homo sapiens	36-44
21392617-2	2011	However, how well CYP2C19 genotype correlates with HPR in patients on maintenance DAPT is less clear.	dapt	82-86	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	18-25
21520992-3	2011	In the present study, we blocked the Notch signaling by DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, a gamma-secretase inhibitor) and investigated the effects on the proliferative and invasive potential of human colorectal cancer LS174T cells, a goblet cell-like colorectal cancer cell line which produces high-levels of MUC2 continuously.	dapt	56-60	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	353-357
21048796-7	2011	Further guidance, under insulin-like growth factor 1 (IGF-1), hepatocyte growth factor (HGF) and N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), was enhanced by glucagon-like peptide-1 (GLP-1) to generate islet-like cells that expressed pancreas-specific markers including insulin and glucagon.	dapt	97-166	glucagon	Homo sapiens	191-214
21048796-7	2011	Further guidance, under insulin-like growth factor 1 (IGF-1), hepatocyte growth factor (HGF) and N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), was enhanced by glucagon-like peptide-1 (GLP-1) to generate islet-like cells that expressed pancreas-specific markers including insulin and glucagon.	dapt	97-166	glucagon	Homo sapiens	216-221
21048796-7	2011	Further guidance, under insulin-like growth factor 1 (IGF-1), hepatocyte growth factor (HGF) and N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), was enhanced by glucagon-like peptide-1 (GLP-1) to generate islet-like cells that expressed pancreas-specific markers including insulin and glucagon.	dapt	97-166	insulin	Homo sapiens	24-31
21512281-8	2011	RAGE-induced ALP and Msx2 expression was completely abrogated by DAPT, an inhibitor of the Notch signaling pathway.	dapt	65-69	advanced glycosylation end-product specific receptor	Homo sapiens	0-4
21512281-8	2011	RAGE-induced ALP and Msx2 expression was completely abrogated by DAPT, an inhibitor of the Notch signaling pathway.	dapt	65-69	alkaline phosphatase, placental	Homo sapiens	13-16
21512281-8	2011	RAGE-induced ALP and Msx2 expression was completely abrogated by DAPT, an inhibitor of the Notch signaling pathway.	dapt	65-69	msh homeobox 2	Homo sapiens	21-25
21512281-8	2011	RAGE-induced ALP and Msx2 expression was completely abrogated by DAPT, an inhibitor of the Notch signaling pathway.	dapt	65-69	notch receptor 1	Homo sapiens	91-96
21812518-5	2011	The results showed that: (1) Notch receptor 1, 2, 3 and 4 were all expressed in CFs; (2) DAPT promoted CMT in a time-dependent manner; (3) During the period of CMT induced by TGF-beta1, expressions of Notch receptor 1, 3 and 4 in CFs were down-regulated, whereas there was no change for Notch receptor 2.	dapt	89-93	transforming growth factor, beta 1	Rattus norvegicus	175-184
21520992-5	2011	Blocking of Notch signaling by DAPT could down-regulate its downstream target gene Hes1, while enhancing the expression of Math1 and MUC2 in LS174T cells.	dapt	31-35	hes family bHLH transcription factor 1	Homo sapiens	83-87
21520992-5	2011	Blocking of Notch signaling by DAPT could down-regulate its downstream target gene Hes1, while enhancing the expression of Math1 and MUC2 in LS174T cells.	dapt	31-35	atonal bHLH transcription factor 1	Homo sapiens	123-128
21520992-5	2011	Blocking of Notch signaling by DAPT could down-regulate its downstream target gene Hes1, while enhancing the expression of Math1 and MUC2 in LS174T cells.	dapt	31-35	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	133-137
21520992-6	2011	In conclusion, we demonstrated that blocking of Notch signaling by DAPT could inhibit the proliferation and invasion of human colorectal cancer LS174T cells and suggested that gamma-secretase inhibitors may provide a targeted therapy for MUC2-positive colorectal tumors.	dapt	67-71	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	238-242
21332343-0	2011	Notch2/Hes-1 pathway plays an important role in renal ischemia and reperfusion injury-associated inflammation and apoptosis and the gamma-secretase inhibitor DAPT has a nephroprotective effect.	dapt	158-162	notch receptor 2	Rattus norvegicus	0-6
21731759-7	2011	Interestingly, leptin upregulatory effects on cell proliferation/migration and pro-angiogenic factors Notch, IL-1 and VEGF/VEGFR-2 were abrogated by a gamma-secretase inhibitor, DAPT, as well as siRNA against CSL.	dapt	178-182	interleukin 1 complex	Mus musculus	79-113
21731759-7	2011	Interestingly, leptin upregulatory effects on cell proliferation/migration and pro-angiogenic factors Notch, IL-1 and VEGF/VEGFR-2 were abrogated by a gamma-secretase inhibitor, DAPT, as well as siRNA against CSL.	dapt	178-182	vascular endothelial growth factor A	Mus musculus	118-122
21731759-7	2011	Interestingly, leptin upregulatory effects on cell proliferation/migration and pro-angiogenic factors Notch, IL-1 and VEGF/VEGFR-2 were abrogated by a gamma-secretase inhibitor, DAPT, as well as siRNA against CSL.	dapt	178-182	kinase insert domain protein receptor	Mus musculus	123-130
21731759-7	2011	Interestingly, leptin upregulatory effects on cell proliferation/migration and pro-angiogenic factors Notch, IL-1 and VEGF/VEGFR-2 were abrogated by a gamma-secretase inhibitor, DAPT, as well as siRNA against CSL.	dapt	178-182	citrate synthase like	Mus musculus	209-212
21332343-8	2011	However, DAPT treatment significantly reduced the level of Scr, BUN, IL-6, TNF-alpha, and NAG.	dapt	9-13	scruffy	Mus musculus	59-62
21332343-8	2011	However, DAPT treatment significantly reduced the level of Scr, BUN, IL-6, TNF-alpha, and NAG.	dapt	9-13	interleukin 6	Rattus norvegicus	69-73
21332343-8	2011	However, DAPT treatment significantly reduced the level of Scr, BUN, IL-6, TNF-alpha, and NAG.	dapt	9-13	tumor necrosis factor	Rattus norvegicus	75-84
21332343-9	2011	Thus, I/R activates Notch2/hes-1 signaling and DAPT treatment can ameliorate the severity of tubular damage after renal IRI, lower the expression of NF-kappaB2, MCP-1, and bax protein, increase the expression of bcl-2 protein, and reduce the ratio of terminal 2-deoxyuridine 5-triphosphate nick end-labeling-positive cells.	dapt	47-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	149-159
21332343-9	2011	Thus, I/R activates Notch2/hes-1 signaling and DAPT treatment can ameliorate the severity of tubular damage after renal IRI, lower the expression of NF-kappaB2, MCP-1, and bax protein, increase the expression of bcl-2 protein, and reduce the ratio of terminal 2-deoxyuridine 5-triphosphate nick end-labeling-positive cells.	dapt	47-51	C-C motif chemokine ligand 2	Rattus norvegicus	161-166
21332343-9	2011	Thus, I/R activates Notch2/hes-1 signaling and DAPT treatment can ameliorate the severity of tubular damage after renal IRI, lower the expression of NF-kappaB2, MCP-1, and bax protein, increase the expression of bcl-2 protein, and reduce the ratio of terminal 2-deoxyuridine 5-triphosphate nick end-labeling-positive cells.	dapt	47-51	BCL2 associated X, apoptosis regulator	Rattus norvegicus	172-175
21332343-9	2011	Thus, I/R activates Notch2/hes-1 signaling and DAPT treatment can ameliorate the severity of tubular damage after renal IRI, lower the expression of NF-kappaB2, MCP-1, and bax protein, increase the expression of bcl-2 protein, and reduce the ratio of terminal 2-deoxyuridine 5-triphosphate nick end-labeling-positive cells.	dapt	47-51	BCL2, apoptosis regulator	Rattus norvegicus	212-217
20692087-5	2010	DAPT inhibited the expression of Notch target gene Hes1 in the cervical loop indicating that Notch signalling was inhibited in the putative stem cells.	dapt	0-4	notch 1	Mus musculus	33-38
21280161-8	2011	Treatment with an inhibitor of gamma-secretase (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) reduced the number of Trp53-/- mammospheres to the level found in Trp53+/+ cells.	dapt	48-117	transformation related protein 53	Mus musculus	141-146
21280161-8	2011	Treatment with an inhibitor of gamma-secretase (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) reduced the number of Trp53-/- mammospheres to the level found in Trp53+/+ cells.	dapt	48-117	transformation related protein 53	Mus musculus	185-190
20800279-2	2010	Aortic endothelial cells (ECs) isolated from diabetic mice demonstrated reduced sprouting capability in vitro, but adding a Notch inhibitor (DAPT) led to cell-density and VEGF-dose dependent enhancement of proliferation, migration and sprouting, in both 2-D and 3-D cultures, as compared to VEGF alone.	dapt	141-145	vascular endothelial growth factor A	Homo sapiens	171-175
20800279-2	2010	Aortic endothelial cells (ECs) isolated from diabetic mice demonstrated reduced sprouting capability in vitro, but adding a Notch inhibitor (DAPT) led to cell-density and VEGF-dose dependent enhancement of proliferation, migration and sprouting, in both 2-D and 3-D cultures, as compared to VEGF alone.	dapt	141-145	vascular endothelial growth factor A	Homo sapiens	291-295
20800279-4	2010	Combining VEGF and DAPT delivery resulted in increased blood vessel density (~150%) and improved tissue perfusion (~160%), as compared to VEGF alone.	dapt	19-23	vascular endothelial growth factor A	Mus musculus	138-142
20484577-11	2010	Furthermore, inhibiting Hes1 by DAPT increases the expression of RGC marker genes.	dapt	32-36	hes family bHLH transcription factor 1	Mus musculus	24-28
21156064-10	2010	LY-411,575 or DAPT also increased survival of primary neurons expressing endogenous full-length mutant huntingtin.	dapt	14-18	huntingtin	Mus musculus	103-113
20969572-7	2010	Activation of Notch signaling increased the number of CD44-positive cells, and treatment with the Notch signal inhibitor, DAPT, at early, but not later, stages of retinal development abolished both CD44-positive cells and Muller glial cells.	dapt	122-126	CD44 antigen	Mus musculus	54-58
20969572-7	2010	Activation of Notch signaling increased the number of CD44-positive cells, and treatment with the Notch signal inhibitor, DAPT, at early, but not later, stages of retinal development abolished both CD44-positive cells and Muller glial cells.	dapt	122-126	CD44 antigen	Mus musculus	198-202
20583103-9	2010	In HOCl-injected mice, DAPT significantly reduced the development of skin and lung fibrosis, decreased skin fibroblast proliferation and ex vivo serum-induced endothelial H(2)O(2) production, and abrogated the production of anti-DNA topoisomerase I antibodies.	dapt	23-27	topoisomerase (DNA) I	Mus musculus	229-248
20692087-5	2010	DAPT inhibited the expression of Notch target gene Hes1 in the cervical loop indicating that Notch signalling was inhibited in the putative stem cells.	dapt	0-4	hes family bHLH transcription factor 1	Mus musculus	51-55
20692087-5	2010	DAPT inhibited the expression of Notch target gene Hes1 in the cervical loop indicating that Notch signalling was inhibited in the putative stem cells.	dapt	0-4	notch 1	Mus musculus	93-98
20648656-0	2010	Nuclear factor-kappaB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the gamma-secretase complex blocker DAPT.	dapt	191-195	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	22-25
20648656-0	2010	Nuclear factor-kappaB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the gamma-secretase complex blocker DAPT.	dapt	191-195	notch 1	Mus musculus	53-58
20648656-5	2010	In BV-2 cells pretreated with N-[N-(3,5-difluorophenacetyl)-1-alany1]-S-phenyglycine t-butyl ester (DAPT), a gamma-secretase inhibitor, followed by LPS stimulation, Notch-1 expression level was enhanced but that of all other markers was suppressed.	dapt	100-104	notch 1	Mus musculus	165-172
20648656-9	2010	However, in rats given an intraperitoneal injection of DAPT prior to LPS, Notch-1 labeling was augmented, but that of TNF-alpha and IL-1beta was reduced.	dapt	55-59	notch receptor 1	Rattus norvegicus	74-81
20648656-9	2010	However, in rats given an intraperitoneal injection of DAPT prior to LPS, Notch-1 labeling was augmented, but that of TNF-alpha and IL-1beta was reduced.	dapt	55-59	tumor necrosis factor	Rattus norvegicus	118-127
20648656-9	2010	However, in rats given an intraperitoneal injection of DAPT prior to LPS, Notch-1 labeling was augmented, but that of TNF-alpha and IL-1beta was reduced.	dapt	55-59	interleukin 1 beta	Rattus norvegicus	132-140
20648656-10	2010	The results suggest that blocking of Notch-1 activation with DAPT would reduce the level of its downstream end product Hes-1 along with suppression of NF-kappaB/p65 translocation, resulting in suppressed production of proinflammatory cytokines.	dapt	61-65	notch receptor 1	Rattus norvegicus	37-44
20648656-10	2010	The results suggest that blocking of Notch-1 activation with DAPT would reduce the level of its downstream end product Hes-1 along with suppression of NF-kappaB/p65 translocation, resulting in suppressed production of proinflammatory cytokines.	dapt	61-65	hes family bHLH transcription factor 1	Rattus norvegicus	119-124
20648656-10	2010	The results suggest that blocking of Notch-1 activation with DAPT would reduce the level of its downstream end product Hes-1 along with suppression of NF-kappaB/p65 translocation, resulting in suppressed production of proinflammatory cytokines.	dapt	61-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	151-160
20648656-10	2010	The results suggest that blocking of Notch-1 activation with DAPT would reduce the level of its downstream end product Hes-1 along with suppression of NF-kappaB/p65 translocation, resulting in suppressed production of proinflammatory cytokines.	dapt	61-65	synaptotagmin 1	Rattus norvegicus	161-164
20534380-8	2010	When Notch signalling was inhibited with the presenilin inhibitor DAPT the expression pattern for kringelchen changed dramatically into a diffused pattern.	dapt	66-70	neurogenic locus notch homolog protein 1-like	Hydra vulgaris	5-10
20351093-11	2010	By using gamma-secretase inhibitor (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester) that interfered Notch signaling and RNA interference that knockdown Notch1 expression, we confirmed that downregulation of Notch1 reduced the invasiveness of the cells.	dapt	36-105	notch receptor 1	Homo sapiens	230-236
20508179-12	2010	The inhibitory effect of Dll4 on interleukin-8 was abolished by DAPT, a Notch inhibitor, or by coculturing activated human monocytes with Ad-sDll4-infected endothelial cells.	dapt	64-68	delta like canonical Notch ligand 4	Homo sapiens	25-29
20508179-12	2010	The inhibitory effect of Dll4 on interleukin-8 was abolished by DAPT, a Notch inhibitor, or by coculturing activated human monocytes with Ad-sDll4-infected endothelial cells.	dapt	64-68	C-X-C motif chemokine ligand 8	Homo sapiens	33-46
20348013-12	2010	Inhibition of Notch activation, by concurrent exposure to DAPT during the induction of EMT attenuated the decrease in E-cadherin expression, limited the increase in alpha-SMA and MMP-2 and -9 expression and decreased Snail expression.	dapt	58-62	cadherin 1	Homo sapiens	118-128
20348013-12	2010	Inhibition of Notch activation, by concurrent exposure to DAPT during the induction of EMT attenuated the decrease in E-cadherin expression, limited the increase in alpha-SMA and MMP-2 and -9 expression and decreased Snail expression.	dapt	58-62	matrix metallopeptidase 2	Homo sapiens	179-191
20348013-12	2010	Inhibition of Notch activation, by concurrent exposure to DAPT during the induction of EMT attenuated the decrease in E-cadherin expression, limited the increase in alpha-SMA and MMP-2 and -9 expression and decreased Snail expression.	dapt	58-62	snail family transcriptional repressor 1	Homo sapiens	217-222
20428807-4	2010	We used the specific gamma-presenilin inhibitor, DAPT, to identify the specificity of activating signals for Notch-1 and created "butterfly-duplex-3548-Gli-1-inhibitory RNA" (i-Gli-1.RNA) to inhibit cell division.	dapt	49-53	GLI family zinc finger 1	Homo sapiens	152-155
20428807-4	2010	We used the specific gamma-presenilin inhibitor, DAPT, to identify the specificity of activating signals for Notch-1 and created "butterfly-duplex-3548-Gli-1-inhibitory RNA" (i-Gli-1.RNA) to inhibit cell division.	dapt	49-53	GLI family zinc finger 1	Homo sapiens	152-157
20428807-7	2010	DAPT inhibited proliferation of cells activated by Jag-1 Low, and increased proliferation of cells activated by Jag-1 High.	dapt	0-4	jagged canonical Notch ligand 1	Homo sapiens	51-56
20428807-7	2010	DAPT inhibited proliferation of cells activated by Jag-1 Low, and increased proliferation of cells activated by Jag-1 High.	dapt	0-4	jagged canonical Notch ligand 1	Homo sapiens	112-117
20178130-10	2010	Fragmentation of CD44 in chondrocytes was blocked in the presence of the metalloproteinase inhibitor GM6001 and the gamma-secretase inhibitor DAPT.	dapt	142-146	CD44 molecule (Indian blood group)	Homo sapiens	17-21
20447060-5	2010	RESULTS: We demonstrated that Notch-2-Hes-1 signalling pathway was inhibited dose-dependently by DAPT in mASCs.	dapt	97-101	notch 2	Mus musculus	30-37
20447060-5	2010	RESULTS: We demonstrated that Notch-2-Hes-1 signalling pathway was inhibited dose-dependently by DAPT in mASCs.	dapt	97-101	hes family bHLH transcription factor 1	Mus musculus	38-43
20447060-6	2010	In addition, transcription of PPAR-gamma was promoted by DAPT before adipogenic induction, while inhibitor of adipogenesis DLK-1/Pref-1 was further depressed.	dapt	57-61	peroxisome proliferator activated receptor gamma	Mus musculus	30-40
20447060-8	2010	On day 4, in differentiated mASCs cases with DAPT pre-treatment, we also found promotion of activation of de-PPAR-gamma and depression of HES-1, DLK-1/Pref-1 mRNA and protein expression.	dapt	45-49	peroxisome proliferator activated receptor gamma	Mus musculus	109-119
20447060-8	2010	On day 4, in differentiated mASCs cases with DAPT pre-treatment, we also found promotion of activation of de-PPAR-gamma and depression of HES-1, DLK-1/Pref-1 mRNA and protein expression.	dapt	45-49	hes family bHLH transcription factor 1	Mus musculus	138-143
20447060-8	2010	On day 4, in differentiated mASCs cases with DAPT pre-treatment, we also found promotion of activation of de-PPAR-gamma and depression of HES-1, DLK-1/Pref-1 mRNA and protein expression.	dapt	45-49	delta like non-canonical Notch ligand 1	Mus musculus	145-150
20447060-8	2010	On day 4, in differentiated mASCs cases with DAPT pre-treatment, we also found promotion of activation of de-PPAR-gamma and depression of HES-1, DLK-1/Pref-1 mRNA and protein expression.	dapt	45-49	delta like non-canonical Notch ligand 1	Mus musculus	151-157
20447060-9	2010	CONCLUSIONS: We conclude that blocking Notch signalling with DAPT enhances adipogenesis of differentiated mASCs at an early stage.	dapt	61-65	notch 1	Mus musculus	39-44
20447060-10	2010	It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-gamma activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT.	dapt	145-149	delta like non-canonical Notch ligand 1	Mus musculus	31-36
20447060-10	2010	It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-gamma activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT.	dapt	145-149	delta like non-canonical Notch ligand 1	Mus musculus	37-43
20447060-10	2010	It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-gamma activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT.	dapt	145-149	peroxisome proliferator activated receptor gamma	Mus musculus	64-74
20447060-10	2010	It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-gamma activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT.	dapt	145-149	notch 2	Mus musculus	120-127
20447060-10	2010	It may be due to depression of DLK-1/Pref-1 and promotion of de-PPAR-gamma activation, which work through inhibition of Notch-2-Hes-1 pathway by DAPT.	dapt	145-149	hes family bHLH transcription factor 1	Mus musculus	128-133
19750540-4	2009	In contrast, the addition of DAPT during primitive ectoderm-like cell differentiation interfered with the ability of both serum and BMP4 to induce a primitive streak-like intermediate and resulted in the preferential formation of neurectoderm.	dapt	29-33	bone morphogenetic protein 4	Homo sapiens	132-136
20117093-7	2010	Down-regulation of Notch1 expression by DAPT was able to substantially inhibit cell growth, induce G1 cell cycle arrest and induce cell apoptosis in A2780 in dose- and time-dependent manner.	dapt	40-44	notch receptor 1	Homo sapiens	19-25
20117093-8	2010	In addition, hes1 was found to be down-regulated in dose- and time-dependent manner by DAPT in A2780.	dapt	87-91	hes family bHLH transcription factor 1	Homo sapiens	13-17
19406255-6	2010	The JAG1 mediated Notch signaling was shown with a Notch inhibitor (DAPT) to be necessary for chondrogenesis, as inhibition days 0-14, or just days 0-5, blocked chondrogenesis, whereas Notch inhibition days 5-14 did not.	dapt	68-72	jagged canonical Notch ligand 1	Homo sapiens	4-8
19953094-8	2010	Rho activity assessment on Notch1 inhibition with DAPT shows decreased RhoC activity.	dapt	50-54	notch receptor 1	Homo sapiens	27-33
19953094-8	2010	Rho activity assessment on Notch1 inhibition with DAPT shows decreased RhoC activity.	dapt	50-54	ras homolog family member C	Homo sapiens	71-75
20079713-6	2010	Hey1, expressed in the nucleus of ASCs to act as a transcriptional repressor, was downregulated when Notch signaling was inhibited by DAPT.	dapt	134-138	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	0-4
20079713-7	2010	Whereas the expression of Runx2 increased in the nucleus of osteogenic induced ASCs after DAPT treatment.	dapt	90-94	RUNX family transcription factor 2	Homo sapiens	26-31
20079713-8	2010	This study demonstrated that DAPT reduced the proliferation and enhanced the osteogenesis in ASCs via regulation of Notch and Runx2 expression.	dapt	29-33	RUNX family transcription factor 2	Homo sapiens	126-131
20056840-4	2010	Blocking Notch signaling activation by intraperitoneal injection of a gamma-secretase inhibitor, DAPT, significantly attenuated peritoneal fibrosis as indicated by the decreased expression of alpha-smooth muscle actin, collagen I, and vascular endothelial growth factor as well as increased expression of E-cadherin.	dapt	97-101	notch receptor 1	Rattus norvegicus	9-14
20056840-4	2010	Blocking Notch signaling activation by intraperitoneal injection of a gamma-secretase inhibitor, DAPT, significantly attenuated peritoneal fibrosis as indicated by the decreased expression of alpha-smooth muscle actin, collagen I, and vascular endothelial growth factor as well as increased expression of E-cadherin.	dapt	97-101	actin gamma 2, smooth muscle	Rattus norvegicus	192-217
20056840-4	2010	Blocking Notch signaling activation by intraperitoneal injection of a gamma-secretase inhibitor, DAPT, significantly attenuated peritoneal fibrosis as indicated by the decreased expression of alpha-smooth muscle actin, collagen I, and vascular endothelial growth factor as well as increased expression of E-cadherin.	dapt	97-101	cadherin 1	Rattus norvegicus	305-315
20056840-7	2010	DAPT blocked this TGF-beta1-induced Notch signaling activation and therefore significantly inhibited TGF-beta1-induced expression of alpha-smooth muscle actin, collagen I, and vascular endothelial growth factor.	dapt	0-4	transforming growth factor, beta 1	Rattus norvegicus	18-27
20056840-7	2010	DAPT blocked this TGF-beta1-induced Notch signaling activation and therefore significantly inhibited TGF-beta1-induced expression of alpha-smooth muscle actin, collagen I, and vascular endothelial growth factor.	dapt	0-4	notch receptor 1	Rattus norvegicus	36-41
20056840-7	2010	DAPT blocked this TGF-beta1-induced Notch signaling activation and therefore significantly inhibited TGF-beta1-induced expression of alpha-smooth muscle actin, collagen I, and vascular endothelial growth factor.	dapt	0-4	transforming growth factor, beta 1	Rattus norvegicus	101-110
20056840-7	2010	DAPT blocked this TGF-beta1-induced Notch signaling activation and therefore significantly inhibited TGF-beta1-induced expression of alpha-smooth muscle actin, collagen I, and vascular endothelial growth factor.	dapt	0-4	actin gamma 2, smooth muscle	Rattus norvegicus	133-158
19833173-6	2009	Treatment of ASC with N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester (DAPT), a gamma-secretase inhibitor which blocks notch signalling, had no effect on up-regulation of SC proteins S100 or GFAP during differentiation.	dapt	93-97	notch receptor 1	Rattus norvegicus	141-146
19833173-6	2009	Treatment of ASC with N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester (DAPT), a gamma-secretase inhibitor which blocks notch signalling, had no effect on up-regulation of SC proteins S100 or GFAP during differentiation.	dapt	93-97	glial fibrillary acidic protein	Rattus norvegicus	213-217
19750540-7	2009	The addition of an E-cadherin neutralizing antibody was able to partially reverse the effect of DAPT, suggesting that DAPT may be preventing the formation of primitive streak-like intermediates and promoting neurectoderm differentiation by stabilizing E-cadherin and preventing its proteolysis.	dapt	96-100	cadherin 1	Homo sapiens	19-29
19750540-7	2009	The addition of an E-cadherin neutralizing antibody was able to partially reverse the effect of DAPT, suggesting that DAPT may be preventing the formation of primitive streak-like intermediates and promoting neurectoderm differentiation by stabilizing E-cadherin and preventing its proteolysis.	dapt	96-100	cadherin 1	Homo sapiens	252-262
19750540-7	2009	The addition of an E-cadherin neutralizing antibody was able to partially reverse the effect of DAPT, suggesting that DAPT may be preventing the formation of primitive streak-like intermediates and promoting neurectoderm differentiation by stabilizing E-cadherin and preventing its proteolysis.	dapt	118-122	cadherin 1	Homo sapiens	19-29
19750540-7	2009	The addition of an E-cadherin neutralizing antibody was able to partially reverse the effect of DAPT, suggesting that DAPT may be preventing the formation of primitive streak-like intermediates and promoting neurectoderm differentiation by stabilizing E-cadherin and preventing its proteolysis.	dapt	118-122	cadherin 1	Homo sapiens	252-262
19490914-5	2009	Using an activated form of Notch and the gamma-secretase inhibitor DAPT, we also found that Notch signaling regulates the transcription of Sox8 and Sox9.	dapt	67-71	SRY (sex determining region Y)-box 8	Mus musculus	139-143
19706332-7	2009	The role of the Notch signaling pathway analyzed with the specific inhibitor, DAPT, and by examining the expression of Notch-related genes using RT-PCR showed that after co-culturing with MSCs for 24h, NSCs expressed much higher levels of ki-67, Notch1, and Hes1 than did NSCs co-cultured with NIH3T3 cells.	dapt	78-82	notch 1	Mus musculus	16-21
19706332-8	2009	Treatment with DAPT decreased ki-67, Notch1 and Hes1 expression in NCSs, and increased Mash1 expression.	dapt	15-19	notch 1	Mus musculus	37-43
19706332-8	2009	Treatment with DAPT decreased ki-67, Notch1 and Hes1 expression in NCSs, and increased Mash1 expression.	dapt	15-19	hes family bHLH transcription factor 1	Mus musculus	48-52
19706332-8	2009	Treatment with DAPT decreased ki-67, Notch1 and Hes1 expression in NCSs, and increased Mash1 expression.	dapt	15-19	achaete-scute family bHLH transcription factor 1	Mus musculus	87-92
19855400-4	2009	We further show that mice with homozygous deletion of Notch3 do not develop pulmonary hypertension in response to hypoxic stimulation and that pulmonary hypertension can be successfully treated in mice by administration of N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a gamma-secretase inhibitor that blocks activation of Notch3 in smooth muscle cells.	dapt	223-292	notch 3	Mus musculus	355-361
19855400-4	2009	We further show that mice with homozygous deletion of Notch3 do not develop pulmonary hypertension in response to hypoxic stimulation and that pulmonary hypertension can be successfully treated in mice by administration of N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a gamma-secretase inhibitor that blocks activation of Notch3 in smooth muscle cells.	dapt	294-298	notch 3	Mus musculus	54-60
19490914-5	2009	Using an activated form of Notch and the gamma-secretase inhibitor DAPT, we also found that Notch signaling regulates the transcription of Sox8 and Sox9.	dapt	67-71	SRY (sex determining region Y)-box 9	Mus musculus	148-152
19662631-6	2009	Treatment of macrophages with the gamma-secretase inhibitor DAPT, which prevents the cleavage and activation of Notch receptors, inhibits all these processes, diminishing NF-kappaB activity following LPS stimulation.	dapt	60-64	notch receptor 1	Homo sapiens	112-117
19789031-9	2009	Inhibition of Notch pathway by DAPT decreased downstream Notch signaling mRNAs and proteins in both cell lines and increased Hath1 and CDX2 proteins only in OE19.	dapt	31-35	atonal bHLH transcription factor 1	Homo sapiens	125-130
19789031-9	2009	Inhibition of Notch pathway by DAPT decreased downstream Notch signaling mRNAs and proteins in both cell lines and increased Hath1 and CDX2 proteins only in OE19.	dapt	31-35	caudal type homeobox 2	Homo sapiens	135-139
19481797-4	2009	Treatment of cultured human endothelial cells with DAPT, a gamma secretase inhibitor, increased cell migration and sprout formation in response to VEGF stimulation with a biphasic dependence on DAPT concentration.	dapt	51-55	vascular endothelial growth factor A	Homo sapiens	147-151
19481797-4	2009	Treatment of cultured human endothelial cells with DAPT, a gamma secretase inhibitor, increased cell migration and sprout formation in response to VEGF stimulation with a biphasic dependence on DAPT concentration.	dapt	194-198	vascular endothelial growth factor A	Homo sapiens	147-151
19481797-5	2009	Further, delivery of an appropriate combination of DAPT and VEGF from an injectable alginate hydrogel system into ischemic hindlimbs led to a faster recovery of blood flow than VEGF or DAPT alone; perfusion levels reached 80% of the normal level by week 4 with combined DAPT and VEGF delivery.	dapt	185-189	vascular endothelial growth factor A	Homo sapiens	60-64
19481797-5	2009	Further, delivery of an appropriate combination of DAPT and VEGF from an injectable alginate hydrogel system into ischemic hindlimbs led to a faster recovery of blood flow than VEGF or DAPT alone; perfusion levels reached 80% of the normal level by week 4 with combined DAPT and VEGF delivery.	dapt	185-189	vascular endothelial growth factor A	Homo sapiens	60-64
19542446-5	2009	The blockade of Notch signaling pathways using a gamma-secretase inhibitor, DAPT (N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester), reduces the survival of GC-B cells in the presence of FDC/HK cells.	dapt	76-80	notch receptor 1	Homo sapiens	16-21
19481073-7	2009	Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased FGF-dependent expression of Jag1 demonstrating Notch-dependent lateral induction.	dapt	63-67	notch receptor 2	Rattus norvegicus	14-19
19481073-7	2009	Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased FGF-dependent expression of Jag1 demonstrating Notch-dependent lateral induction.	dapt	63-67	jagged canonical Notch ligand 1	Rattus norvegicus	151-155
19481073-7	2009	Inhibition of Notch signaling using gamma secretase inhibitors DAPT and L-685,458 or anti-Jag1 antibody markedly decreased FGF-dependent expression of Jag1 demonstrating Notch-dependent lateral induction.	dapt	63-67	notch receptor 2	Rattus norvegicus	170-175
19476545-7	2009	The mRNA and protein levels of CHOP, an ER stress-responsive gene, were remarkably increased by APP over-expression, which was attenuated by treatment with DAPT.	dapt	156-160	DNA damage inducible transcript 3	Homo sapiens	31-35
20687300-8	2009	Coincident with this observation, DAPT induced a dose-dependent promotion of constitutive Caspase-3 in Tca8113 cells.	dapt	34-38	caspase 3	Homo sapiens	90-99
20687300-10	2009	Moreover, the effects of DAPT in tumor inhibition may arise partly via the modulation of Notch-1 and Caspase-3.	dapt	25-29	caspase 3	Homo sapiens	101-110
19595135-8	2009	The K19, K14 and P63 increased their expression in the DAPT treated group (28.6% +/- 5.7%, 53.1% +/- 4.5%, 57.0% +/- 5.8%) relative to the control group (10.1% +/- 2.8%, 30.8% +/- 4.9%, 16.5% +/- 2.2%, all P < 0.01) on day 14 post wounding, while the Involucrin and P21 decreased their expression in the DAPT treated group (12.3% +/- 1.9%, 11.0% +/- 1.7%) relative to the control group (29.3% +/- 4.6%, 44.3% +/- 3.5%, both P < 0.01).	dapt	55-59	keratin, type I cytoskeletal 19	Oryctolagus cuniculus	4-7
19595135-8	2009	The K19, K14 and P63 increased their expression in the DAPT treated group (28.6% +/- 5.7%, 53.1% +/- 4.5%, 57.0% +/- 5.8%) relative to the control group (10.1% +/- 2.8%, 30.8% +/- 4.9%, 16.5% +/- 2.2%, all P < 0.01) on day 14 post wounding, while the Involucrin and P21 decreased their expression in the DAPT treated group (12.3% +/- 1.9%, 11.0% +/- 1.7%) relative to the control group (29.3% +/- 4.6%, 44.3% +/- 3.5%, both P < 0.01).	dapt	55-59	involucrin	Oryctolagus cuniculus	254-264
19595135-8	2009	The K19, K14 and P63 increased their expression in the DAPT treated group (28.6% +/- 5.7%, 53.1% +/- 4.5%, 57.0% +/- 5.8%) relative to the control group (10.1% +/- 2.8%, 30.8% +/- 4.9%, 16.5% +/- 2.2%, all P < 0.01) on day 14 post wounding, while the Involucrin and P21 decreased their expression in the DAPT treated group (12.3% +/- 1.9%, 11.0% +/- 1.7%) relative to the control group (29.3% +/- 4.6%, 44.3% +/- 3.5%, both P < 0.01).	dapt	307-311	keratin, type I cytoskeletal 19	Oryctolagus cuniculus	4-7
18984672-7	2009	Accordingly, inhibition of the Notch pathway with gamma-secretase inhibitor DAPT or NOTCH3-specific small interfering RNA blocked the coculture-induced regulation of several of these genes in fibroblasts.	dapt	76-80	notch receptor 3	Homo sapiens	31-36
19550121-13	2009	DAPT can enhance DDP-sensitivity of Tb3.1 cells via blocking Notch1 signaling.	dapt	0-4	notch receptor 1	Homo sapiens	61-67
19150886-7	2009	Interestingly, we found that the expression of NOTCH3 is dependent on Notch signaling, because the gamma-secretase inhibitor DAPT blocked its upregulation.	dapt	125-129	notch receptor 3	Homo sapiens	47-53
19150886-7	2009	Interestingly, we found that the expression of NOTCH3 is dependent on Notch signaling, because the gamma-secretase inhibitor DAPT blocked its upregulation.	dapt	125-129	notch receptor 3	Homo sapiens	70-75
18983676-12	2008	Finally, the expression levels of Notch target gene her6 in cpd E or DAPT-treated zebrafish were correlated with the degree of tail curvature due to defective somitogenesis, a well characterized Notch phenotype in zebrafish.	dapt	69-73	hairy-related 6	Danio rerio	52-56
18791180-9	2008	Interestingly, cyclooxygenase-2 (COX-2) expression induced by cadmium was also inhibited by DAPT.	dapt	92-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	15-31
18791180-9	2008	Interestingly, cyclooxygenase-2 (COX-2) expression induced by cadmium was also inhibited by DAPT.	dapt	92-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-38
18456406-5	2008	Nevertheless, blockage of Notch enzymatic cleavage with gamma-seacretase inhibitors, DAPT and L-685,458, neither interrupted resveratrol-caused cellular events nor affected MB cell growth.	dapt	85-89	notch receptor 1	Homo sapiens	26-31
18845081-6	2008	Furthermore, the height of the cells in Jagged1 group was higher than that in control and DAPT group, while the diameter of the cells in both was roughly equivalent.	dapt	90-94	jagged canonical Notch ligand 1	Homo sapiens	40-47
18636433-3	2008	Here, we show that transforming growth factor-alpha (TGF-alpha) stimulated glioma cell line U251 growth and can partly compensate for the inhibitory effect of Notch-signaling inhibitor DAPT.	dapt	185-189	tumor necrosis factor	Homo sapiens	19-51
18636433-3	2008	Here, we show that transforming growth factor-alpha (TGF-alpha) stimulated glioma cell line U251 growth and can partly compensate for the inhibitory effect of Notch-signaling inhibitor DAPT.	dapt	185-189	transforming growth factor alpha	Homo sapiens	53-62
18593982-9	2008	Br4 cells were more migratory and invasive than MDA-MB-435 cells in collagen and Matrigel Transwell assays, and the migration and invasion of Br4 cells were significantly inhibited by inactivation of Notch signaling using DAPT, a gamma-secretase inhibitor, and RNA interference-mediated knockdown of Jagged 2 and Notch1.	dapt	222-226	notch receptor 1	Homo sapiens	200-205
18593982-9	2008	Br4 cells were more migratory and invasive than MDA-MB-435 cells in collagen and Matrigel Transwell assays, and the migration and invasion of Br4 cells were significantly inhibited by inactivation of Notch signaling using DAPT, a gamma-secretase inhibitor, and RNA interference-mediated knockdown of Jagged 2 and Notch1.	dapt	222-226	jagged canonical Notch ligand 2	Homo sapiens	300-308
18593982-9	2008	Br4 cells were more migratory and invasive than MDA-MB-435 cells in collagen and Matrigel Transwell assays, and the migration and invasion of Br4 cells were significantly inhibited by inactivation of Notch signaling using DAPT, a gamma-secretase inhibitor, and RNA interference-mediated knockdown of Jagged 2 and Notch1.	dapt	222-226	notch receptor 1	Homo sapiens	313-319
18991739-13	2008	DAPT, an inhibitor of Notch activity, when added contemporary to HNE, further increased cell growth inhibition, without affecting apoptosis.	dapt	0-4	notch receptor 1	Homo sapiens	22-27
18691390-4	2008	APP Tg and APP/PS-1 Tg, but not PS-1 Tg, mice had less NMDA-induced retinal damage than wild-type mice, and the reduced damage in APP/PS-1 Tg mice was diminished by the pre-treatment of N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester, a gamma-secretase inhibitor.	dapt	186-255	presenilin 1	Mus musculus	15-19
18662245-0	2008	The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.	dapt	30-34	cyclin-dependent kinase 5	Rattus norvegicus	50-54
18662245-4	2008	Neurons treated with 10 microM DAPT showed attenuated cdk5 activity in spite of an up-regulation of cdk5 protein level, consistent with a phenomenon reported in the cdk5 transgenic mice.	dapt	31-35	cyclin-dependent kinase 5	Mus musculus	54-58
18662245-4	2008	Neurons treated with 10 microM DAPT showed attenuated cdk5 activity in spite of an up-regulation of cdk5 protein level, consistent with a phenomenon reported in the cdk5 transgenic mice.	dapt	31-35	cyclin-dependent kinase 5	Mus musculus	100-104
18662245-4	2008	Neurons treated with 10 microM DAPT showed attenuated cdk5 activity in spite of an up-regulation of cdk5 protein level, consistent with a phenomenon reported in the cdk5 transgenic mice.	dapt	31-35	cyclin-dependent kinase 5	Mus musculus	100-104
18662245-7	2008	DAPT-induced attenuation of cdk5 activity was restored by over-expression of p35 indicating that it interacted with cdk5 and up-regulated nascent cdk5 activity.	dapt	0-4	cyclin-dependent kinase 5	Rattus norvegicus	28-32
18662245-7	2008	DAPT-induced attenuation of cdk5 activity was restored by over-expression of p35 indicating that it interacted with cdk5 and up-regulated nascent cdk5 activity.	dapt	0-4	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	77-80
18662245-7	2008	DAPT-induced attenuation of cdk5 activity was restored by over-expression of p35 indicating that it interacted with cdk5 and up-regulated nascent cdk5 activity.	dapt	0-4	cyclin-dependent kinase 5	Rattus norvegicus	116-120
18662245-7	2008	DAPT-induced attenuation of cdk5 activity was restored by over-expression of p35 indicating that it interacted with cdk5 and up-regulated nascent cdk5 activity.	dapt	0-4	cyclin-dependent kinase 5	Rattus norvegicus	116-120
18662245-8	2008	p35 over-expression also rescued DAPT-induced translocation of phospho-tau and phospho-neurofilament.	dapt	33-37	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	0-3
18662245-10	2008	Moreover, DAPT up-regulated neurogenin that is negatively regulated by Notch, and down-regulated Hes1, a downstream target of Notch, suggesting that Notch signaling in the cortical neurons was disrupted.	dapt	10-14	hes family bHLH transcription factor 1	Rattus norvegicus	97-101
18662245-11	2008	Semi-quantitative and quantitative RT-PCR analyses confirmed that DAPT up-regulated cdk5 expression at the transcriptional level.	dapt	66-70	cyclin-dependent kinase 5	Rattus norvegicus	84-88
18320325-11	2008	NS-398 and DAPT inhibited cell proliferation and induced apoptosis in a dose time-dependent manner accompanied by significantly decreased Notch1 activity (P < 0.01), and resulted in a significant down-regulation of Hes1 and NF-kappaB2 (P < 0.01).	dapt	11-15	notch receptor 1	Homo sapiens	138-144
18320325-11	2008	NS-398 and DAPT inhibited cell proliferation and induced apoptosis in a dose time-dependent manner accompanied by significantly decreased Notch1 activity (P < 0.01), and resulted in a significant down-regulation of Hes1 and NF-kappaB2 (P < 0.01).	dapt	11-15	hes family bHLH transcription factor 1	Homo sapiens	218-222
17922104-7	2007	Inhibiting Notch signalling with N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) increased Ngn3 mRNA expression and protein levels in adult islets.	dapt	104-108	notch 1	Mus musculus	11-16
18209056-9	2008	Finally, DAPT, a gamma-secretase inhibitor that inhibits Notch signaling, was able to overcome MSC-DC defects.	dapt	9-13	musculin	Homo sapiens	95-101
18192230-6	2008	The JAG-1-mediated Notch signaling was also shown to be necessary for chondrogenesis, as N-[N-(3,5-difluorophenacetyl-L-alanyl)]-(S)-phenylglycine t-butyl ester (DAPT) added to cultures on days 0-14 or just days 0-5 inhibited chondrogenesis, but DAPT added from day 5 did not.	dapt	162-166	jagged canonical Notch ligand 1	Homo sapiens	4-9
18192230-6	2008	The JAG-1-mediated Notch signaling was also shown to be necessary for chondrogenesis, as N-[N-(3,5-difluorophenacetyl-L-alanyl)]-(S)-phenylglycine t-butyl ester (DAPT) added to cultures on days 0-14 or just days 0-5 inhibited chondrogenesis, but DAPT added from day 5 did not.	dapt	246-250	jagged canonical Notch ligand 1	Homo sapiens	4-9
18642791-9	2008	The expression levels of RBP-Jk and Hes1 mRNA (RBP-Jk/GAPDH and Hesl/GAPDH) in the NSC treated with DAPT were 0.52 +/- 0.13 and 0.66 +/- 0.18 respectively, both significantly lower than those of the control group (0.28 +/- 0.06 and 0.16 +/- 0.08 respectively, both P <0.05).	dapt	100-104	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	25-31
18642791-9	2008	The expression levels of RBP-Jk and Hes1 mRNA (RBP-Jk/GAPDH and Hesl/GAPDH) in the NSC treated with DAPT were 0.52 +/- 0.13 and 0.66 +/- 0.18 respectively, both significantly lower than those of the control group (0.28 +/- 0.06 and 0.16 +/- 0.08 respectively, both P <0.05).	dapt	100-104	hes family bHLH transcription factor 1	Homo sapiens	36-40
18642791-9	2008	The expression levels of RBP-Jk and Hes1 mRNA (RBP-Jk/GAPDH and Hesl/GAPDH) in the NSC treated with DAPT were 0.52 +/- 0.13 and 0.66 +/- 0.18 respectively, both significantly lower than those of the control group (0.28 +/- 0.06 and 0.16 +/- 0.08 respectively, both P <0.05).	dapt	100-104	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	47-53
18642791-9	2008	The expression levels of RBP-Jk and Hes1 mRNA (RBP-Jk/GAPDH and Hesl/GAPDH) in the NSC treated with DAPT were 0.52 +/- 0.13 and 0.66 +/- 0.18 respectively, both significantly lower than those of the control group (0.28 +/- 0.06 and 0.16 +/- 0.08 respectively, both P <0.05).	dapt	100-104	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	54-59
18642791-9	2008	The expression levels of RBP-Jk and Hes1 mRNA (RBP-Jk/GAPDH and Hesl/GAPDH) in the NSC treated with DAPT were 0.52 +/- 0.13 and 0.66 +/- 0.18 respectively, both significantly lower than those of the control group (0.28 +/- 0.06 and 0.16 +/- 0.08 respectively, both P <0.05).	dapt	100-104	helt bHLH transcription factor	Homo sapiens	64-68
18642791-9	2008	The expression levels of RBP-Jk and Hes1 mRNA (RBP-Jk/GAPDH and Hesl/GAPDH) in the NSC treated with DAPT were 0.52 +/- 0.13 and 0.66 +/- 0.18 respectively, both significantly lower than those of the control group (0.28 +/- 0.06 and 0.16 +/- 0.08 respectively, both P <0.05).	dapt	100-104	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	69-74
18024430-2	2008	We previously showed that N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a potent dipeptide gamma-secretase inhibitor, causes differential accumulation of longer amyloid beta-proteins (Abetas) within Chinese hamster ovary cells co-expressing beta C-terminal fragment and wild-type presenilin 1 (C99/wtPS1 cells).	dapt	97-101	presenilin-1	Cricetulus griseus	312-324
17922104-7	2007	Inhibiting Notch signalling with N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) increased Ngn3 mRNA expression and protein levels in adult islets.	dapt	104-108	neurogenin 3	Mus musculus	120-124
17630354-3	2007	Differentiation of human CD34(+) cord blood progenitors in IL-15-supplemented fetal thymus organ culture or OP9-Delta-like 1 (DL1) coculture resulted in a high percentage of cyCD3(+) NK cells that was blocked by the gamma-secretase inhibitor DAPT.	dapt	242-246	CD34 molecule	Homo sapiens	25-29
17630354-3	2007	Differentiation of human CD34(+) cord blood progenitors in IL-15-supplemented fetal thymus organ culture or OP9-Delta-like 1 (DL1) coculture resulted in a high percentage of cyCD3(+) NK cells that was blocked by the gamma-secretase inhibitor DAPT.	dapt	242-246	interleukin 15	Homo sapiens	59-64
17630354-3	2007	Differentiation of human CD34(+) cord blood progenitors in IL-15-supplemented fetal thymus organ culture or OP9-Delta-like 1 (DL1) coculture resulted in a high percentage of cyCD3(+) NK cells that was blocked by the gamma-secretase inhibitor DAPT.	dapt	242-246	delta like canonical Notch ligand 1	Homo sapiens	108-124
17630354-3	2007	Differentiation of human CD34(+) cord blood progenitors in IL-15-supplemented fetal thymus organ culture or OP9-Delta-like 1 (DL1) coculture resulted in a high percentage of cyCD3(+) NK cells that was blocked by the gamma-secretase inhibitor DAPT.	dapt	242-246	delta like canonical Notch ligand 1	Homo sapiens	126-129
17510983-8	2007	The glial differentiation and Olig2 translocation could be blocked by inhibition of Notch-1 with the gamma-secretase inhibitor DAPT.	dapt	127-131	oligodendrocyte transcription factor 2	Rattus norvegicus	30-35
17510983-8	2007	The glial differentiation and Olig2 translocation could be blocked by inhibition of Notch-1 with the gamma-secretase inhibitor DAPT.	dapt	127-131	notch receptor 1	Rattus norvegicus	84-91
16413496-16	2006	Jagged1 protein can activate Notch signal and enhance the differentiation of MSC into cardiomyocyte, while the effect can be inhibited by DAPT.	dapt	138-142	jagged canonical Notch ligand 1	Rattus norvegicus	0-7
17295317-6	2007	In the absence of Shh, more interneurons were detected, while the main effect of DAPT on EBs with an activated Shh response was the precocious loss of ventral neuronal precursor-specific markers.	dapt	81-85	sonic hedgehog signaling molecule	Homo sapiens	111-114
16697367-3	2006	We find that the SPP inhibitor (Z-LL)2-ketone (IC50 = 1.33 microM) and the gamma-secretase potent inhibitors NVP-AHW700-NX (IC50 = 51 nM) and LY411575 (IC50 = 61 nM) but not DAPT dose dependently inhibited SPP but not signal peptidase cleavage.	dapt	174-178	histocompatibility minor 13	Homo sapiens	17-20
17627487-8	2007	In vivo efficacy of an Abeta lowering agent was observed in CF-1 mice upon oral administration of the gamma-secretase inhibitors, DAPT and LY-411575.	dapt	130-134	amyloid beta (A4) precursor protein	Mus musculus	23-28
17873349-9	2007	A gamma-secretase inhibitor, DAPT, which inhibits all four Notch receptors and a Notch 4 neutralising antibody were shown to reduce DCIS mammosphere formation, indicating that Notch signalling and other stem cell self-renewal pathways may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.	dapt	29-33	notch receptor 4	Homo sapiens	59-64
17873349-9	2007	A gamma-secretase inhibitor, DAPT, which inhibits all four Notch receptors and a Notch 4 neutralising antibody were shown to reduce DCIS mammosphere formation, indicating that Notch signalling and other stem cell self-renewal pathways may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.	dapt	29-33	notch receptor 4	Homo sapiens	81-88
17472726-7	2007	DAPT treated chrodrocytic pellets had reduced levels of Hes1 and Hey1 suggesting that these effects are mediated via Notch signalling.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	56-60
17472726-7	2007	DAPT treated chrodrocytic pellets had reduced levels of Hes1 and Hey1 suggesting that these effects are mediated via Notch signalling.	dapt	0-4	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	65-69
16959876-10	2006	Treatment with the gamma-secretase inhibitor DAPT down-regulated Notch activity and reduced the proportion of SP cells.	dapt	45-49	notch 1	Mus musculus	65-70
16030192-4	2005	Treatment of cord blood CD34(+) cells with low DAPT concentrations results in aberrant CD4ISP and CD4/CD8 double-positive (DP) thymocytes, which are negative for intracellular T-cell receptor beta (TCRbeta).	dapt	47-51	CD34 molecule	Homo sapiens	24-28
16365048-8	2006	Consistent with the prediction that "preferred" targets (Hes1) should respond faster and at lower Notch concentration than other targets, we showed that Hes5-GFP was extinguished fast and recovered slowly, whereas Hes1-GFP was inhibited late and recovered quickly after a pulse of DAPT in metanephroi cultures.	dapt	281-285	hes family bHLH transcription factor 1	Homo sapiens	57-61
16472156-0	2006	Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors.	dapt	123-127	amyloid beta precursor protein	Rattus norvegicus	13-18
16472156-0	2006	Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors.	dapt	123-127	amyloid beta (A4) precursor protein	Mus musculus	162-167
16622731-7	2006	DAPT treatment also induced chondrogenic markers and bone morphogenetic protein (BMP)-related molecules, including type II collagen, Sox9, GDF5, and Id1.	dapt	0-4	SRY-box transcription factor 9	Homo sapiens	133-137
16622731-7	2006	DAPT treatment also induced chondrogenic markers and bone morphogenetic protein (BMP)-related molecules, including type II collagen, Sox9, GDF5, and Id1.	dapt	0-4	growth differentiation factor 5	Homo sapiens	139-143
16622731-7	2006	DAPT treatment also induced chondrogenic markers and bone morphogenetic protein (BMP)-related molecules, including type II collagen, Sox9, GDF5, and Id1.	dapt	0-4	inhibitor of DNA binding 1, HLH protein	Homo sapiens	149-152
16030192-4	2005	Treatment of cord blood CD34(+) cells with low DAPT concentrations results in aberrant CD4ISP and CD4/CD8 double-positive (DP) thymocytes, which are negative for intracellular T-cell receptor beta (TCRbeta).	dapt	47-51	CD4 molecule	Homo sapiens	87-90
16030192-4	2005	Treatment of cord blood CD34(+) cells with low DAPT concentrations results in aberrant CD4ISP and CD4/CD8 double-positive (DP) thymocytes, which are negative for intracellular T-cell receptor beta (TCRbeta).	dapt	47-51	CD8a molecule	Homo sapiens	102-105
16030192-4	2005	Treatment of cord blood CD34(+) cells with low DAPT concentrations results in aberrant CD4ISP and CD4/CD8 double-positive (DP) thymocytes, which are negative for intracellular T-cell receptor beta (TCRbeta).	dapt	47-51	T cell receptor beta locus	Homo sapiens	198-205
16030192-5	2005	On culture with intermediate and high DAPT concentrations, thymic CD34(+)CD1(-) cells still generate aberrant intracellular TCRbeta(-) DP cells that have undergone DJ but not VDJ recombination.	dapt	38-42	CD34 molecule	Homo sapiens	66-70
16030192-5	2005	On culture with intermediate and high DAPT concentrations, thymic CD34(+)CD1(-) cells still generate aberrant intracellular TCRbeta(-) DP cells that have undergone DJ but not VDJ recombination.	dapt	38-42	CD1b molecule	Homo sapiens	73-76
16030192-5	2005	On culture with intermediate and high DAPT concentrations, thymic CD34(+)CD1(-) cells still generate aberrant intracellular TCRbeta(-) DP cells that have undergone DJ but not VDJ recombination.	dapt	38-42	T cell receptor beta locus	Homo sapiens	124-131
33791203-3	2021	The gamma secretase inhibitors, BMS-708163, GSI-IX, PF-3084014, and RO4929097 abrogated the enzalutamide resistance by inhibiting Notch1 or/and Notch4 in vitro, with GSI-IX and RO4929097 being more effective than BMS-708163 and PF-3084014 in reliving bone metastasis in vivo.	dapt	44-50	notch receptor 1	Homo sapiens	130-136
12626636-0	2003	The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice.	dapt	30-99	amyloid beta (A4) precursor protein	Mus musculus	108-114
12626636-1	2003	Acute, s.c. administration of a gamma-secretase inhibitor, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), to young PDAPP mice dose dependently decreases cortical amyloid-beta (A beta).	dapt	59-128	amyloid beta (A4) precursor protein	Mus musculus	207-213
12626636-2	2003	The present studies replicated these findings in Tg2576 mice and examined further whether DAPT would reduce cerebrospinal fluid (CSF) A beta comparably in young (plaque-free) and aged (plaque-bearing) mice.	dapt	90-94	amyloid beta (A4) precursor protein	Mus musculus	134-140
12626636-3	2003	In the first study, vehicle or DAPT (10, 30, or 100 mg/kg s.c.) administered to young Tg2576 mice (6 months old) dose dependently reduced A beta peptide levels in the cortex as seen previously in the PDAPP mice.	dapt	31-35	amyloid beta (A4) precursor protein	Mus musculus	138-144
12626636-6	2003	DAPT dose dependently reduced A beta levels in the CSF and plasma, but not in the brain wherein A beta levels were 400 to 500 times higher than those in young mice, consistent with a large pool of A beta extracted from amyloid deposits.	dapt	0-4	amyloid beta (A4) precursor protein	Mus musculus	30-36
12626636-6	2003	DAPT dose dependently reduced A beta levels in the CSF and plasma, but not in the brain wherein A beta levels were 400 to 500 times higher than those in young mice, consistent with a large pool of A beta extracted from amyloid deposits.	dapt	0-4	amyloid beta (A4) precursor protein	Mus musculus	96-102
12626636-6	2003	DAPT dose dependently reduced A beta levels in the CSF and plasma, but not in the brain wherein A beta levels were 400 to 500 times higher than those in young mice, consistent with a large pool of A beta extracted from amyloid deposits.	dapt	0-4	amyloid beta (A4) precursor protein	Mus musculus	96-102
12626636-8	2003	DAPT reduced A beta levels in CSF and plasma to a similar extent at both ages.	dapt	0-4	amyloid beta (A4) precursor protein	Mus musculus	13-19
12626636-9	2003	In contrast, DAPT reduced brain A beta levels primarily in young mice, with minimal effects in aged mice.	dapt	13-17	amyloid beta (A4) precursor protein	Mus musculus	32-38
11145990-4	2001	Oral administration of one of these compounds, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, to mice transgenic for human APP(V717F) reduces brain levels of Ass in a dose-dependent manner within 3 h. These studies represent the first demonstration of a reduction of brain A beta in vivo.	dapt	47-116	argininosuccinate synthase 1	Homo sapiens	182-185
11145990-4	2001	Oral administration of one of these compounds, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, to mice transgenic for human APP(V717F) reduces brain levels of Ass in a dose-dependent manner within 3 h. These studies represent the first demonstration of a reduction of brain A beta in vivo.	dapt	47-116	amyloid beta precursor protein	Homo sapiens	297-303
33945189-12	2021	miR-29a-5p-mimics, si-GSAP and DAPT (gamma-secretase inhibitor) inhibited PTH-induced gamma-secretase activation, thus blocking Notch1 pathway activation to inhibit EndMT in vitro.	dapt	31-35	parathyroid hormone	Homo sapiens	74-77
33945189-12	2021	miR-29a-5p-mimics, si-GSAP and DAPT (gamma-secretase inhibitor) inhibited PTH-induced gamma-secretase activation, thus blocking Notch1 pathway activation to inhibit EndMT in vitro.	dapt	31-35	notch receptor 1	Homo sapiens	128-134
33945189-14	2021	Blocking Notch1 pathway activation via AAV-miR-29a and DAPT inhibited valvular EndMT.	dapt	55-59	notch receptor 1	Homo sapiens	9-15
15833746-8	2005	We found that DAPT inhibited cell-cell aggregation and migration in a wound healing assay carried out with Chinese hamster ovary cells expressing beta2.	dapt	14-18	hemoglobin, beta adult minor chain	Mus musculus	146-151
15833746-10	2005	Since DAPT treatment resulted in increased beta2-CTF levels, we also tested whether beta2-CTFs or beta2-ICDs would directly affect cell migration by overexpressing recombinant proteins.	dapt	6-10	hemoglobin, beta adult minor chain	Mus musculus	43-48
14625299-10	2004	In nontransfected or PS1 wild type transfected cells, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester and pepstatin A also attenuated both carbachol-stimulated PI hydrolysis and [Ca2+]i responses to levels found in PS1 D257A or PS1 D385N dominant negative cells.	dapt	54-123	presenilin 1	Homo sapiens	21-24
14625299-10	2004	In nontransfected or PS1 wild type transfected cells, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester and pepstatin A also attenuated both carbachol-stimulated PI hydrolysis and [Ca2+]i responses to levels found in PS1 D257A or PS1 D385N dominant negative cells.	dapt	54-123	presenilin 1	Homo sapiens	237-240
14625299-10	2004	In nontransfected or PS1 wild type transfected cells, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester and pepstatin A also attenuated both carbachol-stimulated PI hydrolysis and [Ca2+]i responses to levels found in PS1 D257A or PS1 D385N dominant negative cells.	dapt	54-123	presenilin 1	Homo sapiens	237-240
12952904-4	2003	We therefore cultured mouse metanephroi in the presence of a gamma-secretase inhibitor, N-S-phenyl-glycine-t-butyl ester (DAPT), to block Notch signaling.	dapt	122-126	notch 1	Mus musculus	138-143
12732196-7	2003	Moreover, gamma-secretase inhibitors, including compound E and DAPT, decreased the calsenilin-induced cell death.	dapt	63-67	potassium voltage-gated channel interacting protein 3	Homo sapiens	83-93
33812110-8	2021	The potential impact of DAPT is effectively analyzed by qPCR, WISH, and Immunofluorescence.	dapt	24-28	NCK interacting protein with SH3 domain	Homo sapiens	62-66
33802884-8	2021	Combination treatment of TSE1 with the Notch1 signaling inhibitor tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate (DAPT), or the Akt signaling inhibitor wortmannin, showed a stronger inhibition toward HIF-1alpha activation compared with single compound treatment.	dapt	66-162	notch receptor 1	Homo sapiens	39-45
33802884-8	2021	Combination treatment of TSE1 with the Notch1 signaling inhibitor tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate (DAPT), or the Akt signaling inhibitor wortmannin, showed a stronger inhibition toward HIF-1alpha activation compared with single compound treatment.	dapt	66-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	250-260
33791203-3	2021	The gamma secretase inhibitors, BMS-708163, GSI-IX, PF-3084014, and RO4929097 abrogated the enzalutamide resistance by inhibiting Notch1 or/and Notch4 in vitro, with GSI-IX and RO4929097 being more effective than BMS-708163 and PF-3084014 in reliving bone metastasis in vivo.	dapt	44-50	notch receptor 4	Homo sapiens	144-150
33791203-4	2021	In conclusion, the Notch1 and Notch4 inhibitors GSI-IX and RO4929097 are promising therapeutic agents for the treatment of CRPC.	dapt	48-54	notch receptor 1	Homo sapiens	19-25
33791203-4	2021	In conclusion, the Notch1 and Notch4 inhibitors GSI-IX and RO4929097 are promising therapeutic agents for the treatment of CRPC.	dapt	48-54	notch receptor 4	Homo sapiens	30-36
34954251-7	2022	Interestingly, Lp(a) activated Notch1 signaling, resulting in cell calcification, which was inhibited by the Notch1 signaling inhibitor, DAPT.	dapt	137-141	lipoprotein(a)	Homo sapiens	15-20
33236156-14	2021	Furthermore, Notch signaling inhibition via DAPT significantly inhibited the pulmonary vascular remodeling effect of AS-IV in vitro and in vivo.	dapt	44-48	notch receptor 3	Homo sapiens	13-18
34954251-7	2022	Interestingly, Lp(a) activated Notch1 signaling, resulting in cell calcification, which was inhibited by the Notch1 signaling inhibitor, DAPT.	dapt	137-141	notch receptor 1	Homo sapiens	31-37
34954251-7	2022	Interestingly, Lp(a) activated Notch1 signaling, resulting in cell calcification, which was inhibited by the Notch1 signaling inhibitor, DAPT.	dapt	137-141	notch receptor 1	Homo sapiens	109-115
34777588-9	2021	Treatment with DAPT upregulated the expression levels of CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBPbeta, peroxisome proliferator-activated receptor-gamma, adiponectin and insulin-like growth factor 1, and promoted the proliferation, apoptosis, migration and lipid accumulation in HemSCs in vitro.	dapt	15-19	CCAAT enhancer binding protein alpha	Homo sapiens	89-101
34741867-7	2021	To dissect the signaling pathway leading to SGK1 upregulation, we pretreated THP-1-derived macrophages with specific inhibitors of Notch (DAPT), AKT (LY294002) or ERK (U0126).	dapt	138-142	serum/glucocorticoid regulated kinase 1	Homo sapiens	44-48
34666595-11	2021	Finally, our findings further verified that DAPT promotes the effects of CYP2J2 on cell viability, migration, and Notch signaling in hypoxia-induced HRVECs, while EDTA reversed the inhibitory effects of CYP2J2 on hypoxia-induced HRVECs.	dapt	44-48	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	73-79
34777588-9	2021	Treatment with DAPT upregulated the expression levels of CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBPbeta, peroxisome proliferator-activated receptor-gamma, adiponectin and insulin-like growth factor 1, and promoted the proliferation, apoptosis, migration and lipid accumulation in HemSCs in vitro.	dapt	15-19	CCAAT enhancer binding protein alpha	Homo sapiens	103-112
34777588-9	2021	Treatment with DAPT upregulated the expression levels of CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBPbeta, peroxisome proliferator-activated receptor-gamma, adiponectin and insulin-like growth factor 1, and promoted the proliferation, apoptosis, migration and lipid accumulation in HemSCs in vitro.	dapt	15-19	peroxisome proliferator activated receptor gamma	Homo sapiens	114-162
34777588-9	2021	Treatment with DAPT upregulated the expression levels of CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBPbeta, peroxisome proliferator-activated receptor-gamma, adiponectin and insulin-like growth factor 1, and promoted the proliferation, apoptosis, migration and lipid accumulation in HemSCs in vitro.	dapt	15-19	adiponectin, C1Q and collagen domain containing	Homo sapiens	164-175
34777588-9	2021	Treatment with DAPT upregulated the expression levels of CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBPbeta, peroxisome proliferator-activated receptor-gamma, adiponectin and insulin-like growth factor 1, and promoted the proliferation, apoptosis, migration and lipid accumulation in HemSCs in vitro.	dapt	15-19	insulin like growth factor 1	Homo sapiens	180-208
34868328-8	2021	The induction of EnMT by hypoxia can be inhibited by using notch3-specific inhibitor DAPT and Jagged-1.	dapt	85-89	notch receptor 3	Homo sapiens	59-65
34804926-11	2021	The gamma-secretase inhibitor DAPT significantly reversed RBM8A-enhanced GBM cell proliferation and invasion, and was associated with down-regulation of p-STAT3 and Notch1 protein.	dapt	30-34	RNA binding motif protein 8A	Homo sapiens	58-63
34559579-5	2021	Indeed, enhancer activity and endogenous DSTN expression were up-regulated by RhoA and TGF-beta signaling and down-regulated by the Notch inhibitor, DAPT.	dapt	149-153	destrin, actin depolymerizing factor	Homo sapiens	41-45
34804926-11	2021	The gamma-secretase inhibitor DAPT significantly reversed RBM8A-enhanced GBM cell proliferation and invasion, and was associated with down-regulation of p-STAT3 and Notch1 protein.	dapt	30-34	signal transducer and activator of transcription 3	Homo sapiens	155-160
34804926-11	2021	The gamma-secretase inhibitor DAPT significantly reversed RBM8A-enhanced GBM cell proliferation and invasion, and was associated with down-regulation of p-STAT3 and Notch1 protein.	dapt	30-34	notch receptor 1	Homo sapiens	165-171
34410624-16	2021	Finally, DAPT injection could reduce inflammation, CD8+Tc infiltration, NICD expression, and bile duct damage after RRV infection.	dapt	9-13	CD8a molecule	Homo sapiens	51-54
34410624-18	2021	CONCLUSION: The DAPT-based intervention could reduce expression of CD8+Tc and bile duct damage in BA mouse livers post-RRV infection.	dapt	16-20	CD8a molecule	Homo sapiens	67-70
34101134-2	2021	For patients undergoing a percutaneous coronary intervention (PCI) temporary dual antiplatelet platelet therapy (DAPT: aspirin combined with a P2Y12 blocker) is mandatory, but leads to more bleeding than single antiplatelet therapy with aspirin.	dapt	113-117	purinergic receptor P2Y12	Homo sapiens	143-148
34320265-10	2021	At last, as a Notch signaling inhibitor, the gamma-secretase inhibitor N-(N-(3,5-difl uorophenacetyl)-L-alanyl)-S-phenylglycine t-butyl ester (DAPT) pretreatment could alleviate the expression of collagens and the symptoms of fibrosis.	dapt	143-147	notch 1	Mus musculus	14-19
34646085-6	2021	A gamma-secretase inhibitor, DAPT, was intrathecally injected to modulate Notch1 signaling indirectly.	dapt	29-33	notch receptor 1	Rattus norvegicus	74-80
34646085-11	2021	Furthermore, treatment with DAPT attenuated mechanical allodynia in CYP-induced cystitis and inhibited microglia activation, leading to decreased production of TNF-alpha and IL-1beta.	dapt	28-32	tumor necrosis factor	Rattus norvegicus	160-169
34646085-11	2021	Furthermore, treatment with DAPT attenuated mechanical allodynia in CYP-induced cystitis and inhibited microglia activation, leading to decreased production of TNF-alpha and IL-1beta.	dapt	28-32	interleukin 1 alpha	Rattus norvegicus	174-182
34363303-9	2021	However, the Notch inhibitor N-(N-(3,5-difluorophenacetyl)-L-alanyl)-S-phenylglycine t-butyl ester (DAPT) suppressed activation of Notch signalling as well as proliferation and migration of the TGFbeta1-treated HUSFs.	dapt	100-104	notch receptor 1	Rattus norvegicus	13-18
34335900-11	2021	In addition, the Notch1/Hes1 pathway inhibitor DAPT significantly downregulated the expression of FOXP3 in a dose-dependent manner.	dapt	47-51	notch receptor 1	Homo sapiens	17-23
34335900-11	2021	In addition, the Notch1/Hes1 pathway inhibitor DAPT significantly downregulated the expression of FOXP3 in a dose-dependent manner.	dapt	47-51	hes family bHLH transcription factor 1	Homo sapiens	24-28
34335900-11	2021	In addition, the Notch1/Hes1 pathway inhibitor DAPT significantly downregulated the expression of FOXP3 in a dose-dependent manner.	dapt	47-51	forkhead box P3	Homo sapiens	98-103
34410948-7	2021	After treatment with DAPT, hPMSCs upregulated the expression of neuronal genes including SOX2, Nestin, and betaIII-tubulin, and the autophagy genes LC3I/II and Beclin.	dapt	21-25	SRY-box transcription factor 2	Homo sapiens	89-93
34410948-7	2021	After treatment with DAPT, hPMSCs upregulated the expression of neuronal genes including SOX2, Nestin, and betaIII-tubulin, and the autophagy genes LC3I/II and Beclin.	dapt	21-25	nestin	Homo sapiens	95-101
34363303-9	2021	However, the Notch inhibitor N-(N-(3,5-difluorophenacetyl)-L-alanyl)-S-phenylglycine t-butyl ester (DAPT) suppressed activation of Notch signalling as well as proliferation and migration of the TGFbeta1-treated HUSFs.	dapt	100-104	transforming growth factor beta 1	Homo sapiens	194-202
34363303-10	2021	Additionally, DAPT ameliorated TGFbeta1-induced urethral fibrosis in Sprague Dawley rats by suppressing ECM production, myofibroblast activation and the TGFbeta signalling pathway.	dapt	14-18	transforming growth factor, beta 1	Rattus norvegicus	31-39
34363303-10	2021	Additionally, DAPT ameliorated TGFbeta1-induced urethral fibrosis in Sprague Dawley rats by suppressing ECM production, myofibroblast activation and the TGFbeta signalling pathway.	dapt	14-18	transforming growth factor alpha	Rattus norvegicus	153-160
34363303-9	2021	However, the Notch inhibitor N-(N-(3,5-difluorophenacetyl)-L-alanyl)-S-phenylglycine t-butyl ester (DAPT) suppressed activation of Notch signalling as well as proliferation and migration of the TGFbeta1-treated HUSFs.	dapt	100-104	notch receptor 1	Rattus norvegicus	131-136
34346482-7	2021	They rapidly recovered their expression levels after DAPT removal and possess Notch-responsive RBPJ transcription factor-binding sites in their regulatory regions.	dapt	53-57	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	95-99
34245840-2	2021	Here, we present a novel target, a truncated form of neogenin that is associated with seizure-induced hippocampal necroptosis, and novel use of the gamma-secretase inhibitor N-(N-(3,5-Difluorophenacetyl)-L-alanyl)-S-phenylglycine t-butyl ester (DAPT) as a pharmacological regulator of neogenin truncation.	dapt	245-249	neogenin	Mus musculus	285-293
34245840-6	2021	Notably, treatment with DAPT prevented neogenin truncation and protected cultured neurons from N-methyl-D-aspartate (NMDA)-induced death.	dapt	24-28	neogenin	Mus musculus	39-47
34245840-7	2021	These data suggest that seizure-induced hippocampal necroptosis is associated with the generation of truncated neogenin, and that prevention of this by DAPT treatment can protect against NMDA-induced excitotoxicity.	dapt	152-156	neogenin	Mus musculus	111-119
34447343-3	2021	Methods: We enrolled and allocated 275 recurrent ischemic stroke patients to the clopidogrel and DAPT groups and compared their demographics, conventional risk factors, and P2Y12 reaction units (PRUs).	dapt	97-101	purinergic receptor P2Y12	Homo sapiens	173-178
34462426-6	2021	Furthermore, DAPT, a gamma-secretase inhibitor, reversed the effects induced by mDC or rmJagged1-hFc.	dapt	13-17	decorin	Mus musculus	80-83
34295560-0	2021	DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	130-134
34395412-4	2021	In vitro, Jam3 expression varies along airway basal stem cell (BSC) differentiation and upon DAPT treatment or IL6 exposure.	dapt	93-97	junction adhesion molecule 3	Mus musculus	10-14
34130659-13	2021	Furthermore, the up-regulated expression of Notch signaling pathway and effects induced by EGFL8 knockdown in Hep3B cells could be counteracted by DAPT treatment.	dapt	147-151	EGF like domain multiple 8	Homo sapiens	91-96
34109563-6	2022	Moreover, increased phosphorylation level of ERK, JNK and P38 induced by LPS was attenuated with pretreatment of Notch-1 signaling inhibitor, N-(N-(3,5-difluorophenacetyl)-1-alany1-Sphenyglycinet-butylester (DAPT) as well as Gastrodin.	dapt	208-212	Eph receptor B1	Rattus norvegicus	45-48
34109563-6	2022	Moreover, increased phosphorylation level of ERK, JNK and P38 induced by LPS was attenuated with pretreatment of Notch-1 signaling inhibitor, N-(N-(3,5-difluorophenacetyl)-1-alany1-Sphenyglycinet-butylester (DAPT) as well as Gastrodin.	dapt	208-212	mitogen-activated protein kinase 8	Rattus norvegicus	50-53
34109563-6	2022	Moreover, increased phosphorylation level of ERK, JNK and P38 induced by LPS was attenuated with pretreatment of Notch-1 signaling inhibitor, N-(N-(3,5-difluorophenacetyl)-1-alany1-Sphenyglycinet-butylester (DAPT) as well as Gastrodin.	dapt	208-212	mitogen activated protein kinase 14	Rattus norvegicus	58-61
34109563-7	2022	Gastrodin mimicked the effects of DAPT by inhibiting the LPS-induced expression of IL-1beta, IL-6, IL-23, TNF-alpha and NO.	dapt	34-38	interleukin 1 alpha	Rattus norvegicus	83-91
34109563-7	2022	Gastrodin mimicked the effects of DAPT by inhibiting the LPS-induced expression of IL-1beta, IL-6, IL-23, TNF-alpha and NO.	dapt	34-38	interleukin 6	Rattus norvegicus	93-97
34109563-7	2022	Gastrodin mimicked the effects of DAPT by inhibiting the LPS-induced expression of IL-1beta, IL-6, IL-23, TNF-alpha and NO.	dapt	34-38	tumor necrosis factor	Rattus norvegicus	106-115
34118144-6	2021	RESULTS: Specifically inhibiting Notch signaling with DAPT decreased the expression of SC-specific marker genes GFAP, S100 and P75, as well as of SC-myelin-related genes PMP22, MBP, connexin, and P0 in cells undergoing induced differentiation from PDLSCs.	dapt	54-58	glial fibrillary acidic protein	Canis lupus familiaris	112-116
34118144-6	2021	RESULTS: Specifically inhibiting Notch signaling with DAPT decreased the expression of SC-specific marker genes GFAP, S100 and P75, as well as of SC-myelin-related genes PMP22, MBP, connexin, and P0 in cells undergoing induced differentiation from PDLSCs.	dapt	54-58	peripheral myelin protein 22	Canis lupus familiaris	170-175
34118144-6	2021	RESULTS: Specifically inhibiting Notch signaling with DAPT decreased the expression of SC-specific marker genes GFAP, S100 and P75, as well as of SC-myelin-related genes PMP22, MBP, connexin, and P0 in cells undergoing induced differentiation from PDLSCs.	dapt	54-58	myelin basic protein	Canis lupus familiaris	177-180
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	85-89	AKT serine/threonine kinase 1	Homo sapiens	33-36
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	85-89	mechanistic target of rapamycin kinase	Homo sapiens	37-41
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	181-185	notch receptor 1	Homo sapiens	18-24
34295560-0	2021	DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	0-4	phosphatase and tensin homolog	Homo sapiens	135-139
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	181-185	AKT serine/threonine kinase 1	Homo sapiens	33-36
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	181-185	matrix metallopeptidase 2	Homo sapiens	207-211
34295560-11	2021	The antitumor properties and regulatory effect of DAPT against the extracellular matrix (ECM) and Hes1/PTEN/AKT/mTOR signaling were verified by the HepG2 xenograft experiments.	dapt	50-54	hes family bHLH transcription factor 1	Homo sapiens	98-102
34295560-12	2021	Conclusions: DAPT could suppress the proliferation and migration of HCC by regulating the ECM and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	13-17	hes family bHLH transcription factor 1	Homo sapiens	113-117
34295560-12	2021	Conclusions: DAPT could suppress the proliferation and migration of HCC by regulating the ECM and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	13-17	phosphatase and tensin homolog	Homo sapiens	118-122
34295560-12	2021	Conclusions: DAPT could suppress the proliferation and migration of HCC by regulating the ECM and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	13-17	AKT serine/threonine kinase 1	Homo sapiens	123-126
34295560-12	2021	Conclusions: DAPT could suppress the proliferation and migration of HCC by regulating the ECM and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	13-17	mechanistic target of rapamycin kinase	Homo sapiens	127-131
34295560-0	2021	DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	0-4	AKT serine/threonine kinase 1	Homo sapiens	140-143
34295560-0	2021	DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	0-4	mechanistic target of rapamycin kinase	Homo sapiens	144-148
34295560-9	2021	DAPT significantly inhibited the proliferation and migration of HepG2 cells in a dose-dependent manner, accompanied by the suppression of Notch1/Hes1 signaling, inactivation of AKT/mTOR signaling, downregulation of MMPs, and decreased expression of adhesion molecules.	dapt	0-4	notch receptor 1	Homo sapiens	138-144
34295560-9	2021	DAPT significantly inhibited the proliferation and migration of HepG2 cells in a dose-dependent manner, accompanied by the suppression of Notch1/Hes1 signaling, inactivation of AKT/mTOR signaling, downregulation of MMPs, and decreased expression of adhesion molecules.	dapt	0-4	hes family bHLH transcription factor 1	Homo sapiens	145-149
34295560-9	2021	DAPT significantly inhibited the proliferation and migration of HepG2 cells in a dose-dependent manner, accompanied by the suppression of Notch1/Hes1 signaling, inactivation of AKT/mTOR signaling, downregulation of MMPs, and decreased expression of adhesion molecules.	dapt	0-4	AKT serine/threonine kinase 1	Homo sapiens	177-180
34295560-9	2021	DAPT significantly inhibited the proliferation and migration of HepG2 cells in a dose-dependent manner, accompanied by the suppression of Notch1/Hes1 signaling, inactivation of AKT/mTOR signaling, downregulation of MMPs, and decreased expression of adhesion molecules.	dapt	0-4	mechanistic target of rapamycin kinase	Homo sapiens	181-185
34295560-9	2021	DAPT significantly inhibited the proliferation and migration of HepG2 cells in a dose-dependent manner, accompanied by the suppression of Notch1/Hes1 signaling, inactivation of AKT/mTOR signaling, downregulation of MMPs, and decreased expression of adhesion molecules.	dapt	0-4	matrix metallopeptidase 2	Homo sapiens	215-219
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	85-89	notch receptor 1	Homo sapiens	18-24
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	85-89	hes family bHLH transcription factor 1	Homo sapiens	25-29
34104086-0	2021	gamma-secretase inhibitors, DAPT and RO4929097, promote the migration of Human Glioma Cells via Smad5-downregulated E-cadherin Expression.	dapt	28-32	SMAD family member 5	Homo sapiens	96-101
34104086-0	2021	gamma-secretase inhibitors, DAPT and RO4929097, promote the migration of Human Glioma Cells via Smad5-downregulated E-cadherin Expression.	dapt	28-32	cadherin 1	Homo sapiens	116-126
34104086-5	2021	It was shown that gamma-secretase activity inhibition by DAPT and RO4929097 could promote LN18 and LN229 glioma cell migration via downregulating E-cadherin mRNA and protein expressions, but not via affecting E-cadherin protein processing.	dapt	57-61	cadherin 1	Homo sapiens	146-156
35489123-5	2022	The upregulation of Notch1, Notch1 intracellular domain (NICD), and Hes1 proteins by LPS treatment was inhibited by DAPT, a Notch1 inhibitor.	dapt	116-120	notch 1	Mus musculus	20-26
35489123-5	2022	The upregulation of Notch1, Notch1 intracellular domain (NICD), and Hes1 proteins by LPS treatment was inhibited by DAPT, a Notch1 inhibitor.	dapt	116-120	hes family bHLH transcription factor 1	Mus musculus	68-72
35489123-5	2022	The upregulation of Notch1, Notch1 intracellular domain (NICD), and Hes1 proteins by LPS treatment was inhibited by DAPT, a Notch1 inhibitor.	dapt	116-120	notch 1	Mus musculus	28-34
35489123-5	2022	The upregulation of Notch1, Notch1 intracellular domain (NICD), and Hes1 proteins by LPS treatment was inhibited by DAPT, a Notch1 inhibitor.	dapt	116-120	notch 1	Mus musculus	124-130
35508987-17	2022	Critically, both suppression of Notch pathway activation by DAPT treatment or downregulation of Notch1 expression by shRNA reverses NDR1 enhanced BCSC properties.	dapt	60-64	notch receptor 1	Homo sapiens	32-37
35489123-6	2022	Additionally, the increased TNF-alpha, IL-6, and IL-1beta expression induced by LPS was inhibited by DAPT and rescued by jagged1, a Notch1 ligand.	dapt	101-105	tumor necrosis factor	Mus musculus	28-37
35489123-6	2022	Additionally, the increased TNF-alpha, IL-6, and IL-1beta expression induced by LPS was inhibited by DAPT and rescued by jagged1, a Notch1 ligand.	dapt	101-105	interleukin 6	Mus musculus	39-43
35489123-6	2022	Additionally, the increased TNF-alpha, IL-6, and IL-1beta expression induced by LPS was inhibited by DAPT and rescued by jagged1, a Notch1 ligand.	dapt	101-105	interleukin 1 alpha	Mus musculus	49-57
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	notch 1	Mus musculus	28-33
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	CYLD lysine 63 deubiquitinase	Mus musculus	81-85
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	TNF receptor-associated factor 6	Mus musculus	116-121
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	conserved helix-loop-helix ubiquitous kinase	Mus musculus	134-165
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	236-249
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	282-291
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	47-51	toll-like receptor 4	Mus musculus	316-321
35489123-7	2022	Furthermore, suppression of Notch signaling by DAPT upregulated Cylindromatosis (CYLD) expression but downregulated TRAF6 expression, IkappaB kinase (IKK) alpha/beta phosphorylation, and subsequently, phosphorylation and degradation of IkappaB-alpha, indicating that DAPT inhibited NF-kappaB activation triggered by TLR-4.	dapt	267-271	notch 1	Mus musculus	28-33
35358299-11	2022	Thrombin generation and clot formation were normal in blood from high dose DAPT- or ibrutinib-treated mice; however, platelet adhesion and platelet-neutrophil aggregate formation at the vein wall were reduced in high dose DAPT- or ibrutinib-treated mice.	dapt	75-79	coagulation factor II	Mus musculus	0-8
35571137-0	2022	DAPT Attenuates Cadmium-Induced Toxicity in Mice by Inhibiting Inflammation and the Notch/HES-1 Signaling Axis.	dapt	0-4	hes family bHLH transcription factor 1	Mus musculus	90-95
35571137-7	2022	However, DAPT down regulated the elevated Notch/HES-1 signaling axis to normal, eliminating inflammation and thus protecting the nervous system.	dapt	9-13	hes family bHLH transcription factor 1	Mus musculus	48-53
35280902-10	2022	Our results showed that IL-7 promoted proliferation and inhibited apoptosis in hPDLCs, promoted the expression of TGF-beta, PD-L1, Notch1, Jagged1, and Hes1, and inhibited the levels of hypoxia-inducible factor (HIF)-1alpha and TCF7, whereas the addition of DAPT effectively reversed these effects.	dapt	258-262	interleukin 7	Homo sapiens	24-28
35212196-7	2022	The function of Notch1 was evaluated with gamma-secretase inhibitor DAPT and genetic knockdown using shRNA strategy.	dapt	68-72	notch receptor 1	Homo sapiens	16-22
35212196-10	2022	Blockade of Notch1 using DAPT and Notch1 shRNA efficiently abrogated mTORC1 activation and pro-inflammatory T cell differentiation.	dapt	25-29	notch receptor 1	Homo sapiens	12-18
35212196-10	2022	Blockade of Notch1 using DAPT and Notch1 shRNA efficiently abrogated mTORC1 activation and pro-inflammatory T cell differentiation.	dapt	25-29	CREB regulated transcription coactivator 1	Mus musculus	69-75
35306046-6	2022	In contrast, increased MMP-9 expression by AGEs-stimulation was eliminated after treatment with DAPT.	dapt	96-100	matrix metallopeptidase 9	Rattus norvegicus	23-28
34000356-5	2021	There was strong agreement favouring monotherapy with either aspirin or a P2Y12 inhibitor following initial DAPT, within the first year (94%).	dapt	108-112	purinergic receptor P2Y12	Homo sapiens	74-79
34987110-5	2022	Blockade of gamma-secretase activity by a gamma-secretase inhibitor, DAPT, decreased ApoE secretion, suggesting an important role of gamma-secretase activity in ApoE secretion.	dapt	69-73	apolipoprotein E	Homo sapiens	85-89
33907837-8	2021	Importantly, we noted that treatment with a Notch signaling inhibitor DAPT produced very similar anticancer efficacy in both HepG2 and Huh-7 cell lines, and administration of DAPT also efficiently suppressed HepG2 xenograft outgrowth.	dapt	70-74	notch receptor 1	Homo sapiens	44-49
33907837-8	2021	Importantly, we noted that treatment with a Notch signaling inhibitor DAPT produced very similar anticancer efficacy in both HepG2 and Huh-7 cell lines, and administration of DAPT also efficiently suppressed HepG2 xenograft outgrowth.	dapt	175-179	notch receptor 1	Homo sapiens	44-49
33907837-9	2021	To this end, we anticipated that AB4 and DAPT may act on the same signaling pathway, probably through inhibition of the Notch pathway.	dapt	41-45	notch receptor 1	Homo sapiens	120-125
35211631-6	2022	Fbn1mgR/mgR and wild-type mice were treated with a gamma-secretase inhibitor, DAPT, to block Notch activation.	dapt	78-82	notch receptor 3	Homo sapiens	93-98
35211631-10	2022	Inhibiting Notch3 activation with DAPT attenuated aortic enlargement and improved survival of Fbn1mgR/mgR mice.	dapt	34-38	notch 3	Mus musculus	11-17
35211631-11	2022	DAPT treatment reduced elastin fiber fragmentation in the aorta and reversed the differentiation of SMCs.	dapt	0-4	elastin	Mus musculus	23-30
3410637-6	1988	However, when there is a purine nucleoside, as in dApT and dApdA, a decrease in the pK2 value was observed and we propose that in such cases the phosphate group interacts in a secondary phosphate binding site, p2.	dapt	50-54	prokineticin 2	Bos taurus	84-87
34039032-1	2021	BACKGROUND AND PURPOSE: We performed a systemic review and meta-analysis to elucidate the effectiveness and safety of dual antiplatelet (DAPT) therapy with P2Y12 inhibitors (clopidogrel/ticagrelor) and aspirin versus aspirin monotherapy in patients with mild ischemic stroke or high-risk transient ischemic attack.	dapt	137-141	purinergic receptor P2Y12	Homo sapiens	156-161
33622250-10	2021	On the other hand, after the combined cytokine treatment of cells, and exposure to jagged-1 and DAPT or HES-1 siRNA, there was a decrease in the Th22 cell proportion, mRNA and protein expression of HES-1, AHR, and IL-22.	dapt	96-100	hes family bHLH transcription factor 1	Homo sapiens	198-203
33976158-3	2021	Moreover, RFC4 is a functional transcriptional target gene of Notch1 signaling, forming a positive feedback loop between high RFC4 and NICD1 levels and sustained overactivation of Notch signaling, which not only leads to NSCLC tumorigenicity and metastasis but also confers NSCLC cell resistance to treatment with the clinically tested drug DAPT against NICD1 synthesis.	dapt	341-345	replication factor C subunit 4	Homo sapiens	10-14
33976158-3	2021	Moreover, RFC4 is a functional transcriptional target gene of Notch1 signaling, forming a positive feedback loop between high RFC4 and NICD1 levels and sustained overactivation of Notch signaling, which not only leads to NSCLC tumorigenicity and metastasis but also confers NSCLC cell resistance to treatment with the clinically tested drug DAPT against NICD1 synthesis.	dapt	341-345	notch receptor 1	Homo sapiens	62-68
33976158-3	2021	Moreover, RFC4 is a functional transcriptional target gene of Notch1 signaling, forming a positive feedback loop between high RFC4 and NICD1 levels and sustained overactivation of Notch signaling, which not only leads to NSCLC tumorigenicity and metastasis but also confers NSCLC cell resistance to treatment with the clinically tested drug DAPT against NICD1 synthesis.	dapt	341-345	replication factor C subunit 4	Homo sapiens	126-130
33976158-3	2021	Moreover, RFC4 is a functional transcriptional target gene of Notch1 signaling, forming a positive feedback loop between high RFC4 and NICD1 levels and sustained overactivation of Notch signaling, which not only leads to NSCLC tumorigenicity and metastasis but also confers NSCLC cell resistance to treatment with the clinically tested drug DAPT against NICD1 synthesis.	dapt	341-345	notch receptor 1	Homo sapiens	62-67
34035674-7	2021	DAPT 3Mo + P2Y12 (OR: 0.58, 95% CI: 0.38-0.88) reduced the risk of any bleeding when compared with DAPT 12Mo.	dapt	0-4	purinergic receptor P2Y12	Homo sapiens	11-16
34035674-9	2021	DAPT 3Mo + P2Y12 decreased the risk of NACE in comparison with DAPT 6Mo and DAPT 12Mo.	dapt	0-4	purinergic receptor P2Y12	Homo sapiens	11-16
33649841-9	2021	In addition, the GASC1 inhibitor caffeic acid and/or the NOTCH1 inhibitor DAPT (a gamma-Secretase Inhibitor), efficiently suppressed the human glioma xenograft tumors.	dapt	74-78	notch receptor 1	Homo sapiens	57-63
33610041-4	2021	Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	229-298	notch receptor 1	Homo sapiens	23-29
33610041-4	2021	Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	229-298	notch receptor 1	Homo sapiens	212-218
33610041-4	2021	Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	300-304	notch receptor 1	Homo sapiens	23-29
33610041-4	2021	Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT).	dapt	300-304	notch receptor 1	Homo sapiens	212-218
32717254-7	2021	Administration of DAPT to mice during the OIT treatment period inhibited the establishment of SU to OVA, but did not affect the induction of desensitization.	dapt	18-22	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	100-103
33600815-11	2021	In addition, blocking the Notch signaling pathway with the inhibitor DAPT significantly mitigated the effect of LXA4 on microglia differentiation.	dapt	69-73	notch receptor 1	Rattus norvegicus	26-31
33385372-1	2021	In the present study, Death receptor-5 (DR5) antibody conjugated solid lipid nanoparticles (DR5-DAPT-SLNs) has been formulated for effective intracellular of gamma-secretase inhibitor, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) to cancer cells.	dapt	185-254	TNF receptor superfamily member 10b	Homo sapiens	22-38
33385372-1	2021	In the present study, Death receptor-5 (DR5) antibody conjugated solid lipid nanoparticles (DR5-DAPT-SLNs) has been formulated for effective intracellular of gamma-secretase inhibitor, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) to cancer cells.	dapt	185-254	TNF receptor superfamily member 10b	Homo sapiens	40-43
33385372-1	2021	In the present study, Death receptor-5 (DR5) antibody conjugated solid lipid nanoparticles (DR5-DAPT-SLNs) has been formulated for effective intracellular of gamma-secretase inhibitor, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) to cancer cells.	dapt	185-254	TNF receptor superfamily member 10b	Homo sapiens	92-95
33385372-1	2021	In the present study, Death receptor-5 (DR5) antibody conjugated solid lipid nanoparticles (DR5-DAPT-SLNs) has been formulated for effective intracellular of gamma-secretase inhibitor, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) to cancer cells.	dapt	96-100	TNF receptor superfamily member 10b	Homo sapiens	22-38
33385372-1	2021	In the present study, Death receptor-5 (DR5) antibody conjugated solid lipid nanoparticles (DR5-DAPT-SLNs) has been formulated for effective intracellular of gamma-secretase inhibitor, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) to cancer cells.	dapt	96-100	TNF receptor superfamily member 10b	Homo sapiens	40-43
33385372-1	2021	In the present study, Death receptor-5 (DR5) antibody conjugated solid lipid nanoparticles (DR5-DAPT-SLNs) has been formulated for effective intracellular of gamma-secretase inhibitor, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) to cancer cells.	dapt	96-100	TNF receptor superfamily member 10b	Homo sapiens	92-95
33385372-6	2021	DR5-DAPT-SLNs have higher cytotoxicity in MDA-MB231 cells compared to DAPT-SLNs (non-targeted) and the bulk drug.	dapt	4-8	TNF receptor superfamily member 10b	Homo sapiens	0-3
33385372-8	2021	The above results, therefore, demonstrate DR5 mediated uptake is responsible for improved cytotoxicity of DAPT.	dapt	106-110	TNF receptor superfamily member 10b	Homo sapiens	42-45
33385372-9	2021	In the in vivo anticancer study, DR5-DAPT-SLNs show greater tumor regression when compared to DAPT-SLNs and the bulk drug.	dapt	37-41	TNF receptor superfamily member 10b	Homo sapiens	33-36
33385372-10	2021	In conclusion, the results of the present study demonstrate that the DR5-DAPT-SLNs selectively target cancer cells and potentiate the anticancer efficacy of DAPT against TNBC cells.	dapt	73-77	TNF receptor superfamily member 10b	Homo sapiens	69-72
33385372-10	2021	In conclusion, the results of the present study demonstrate that the DR5-DAPT-SLNs selectively target cancer cells and potentiate the anticancer efficacy of DAPT against TNBC cells.	dapt	157-161	TNF receptor superfamily member 10b	Homo sapiens	69-72
33622250-10	2021	On the other hand, after the combined cytokine treatment of cells, and exposure to jagged-1 and DAPT or HES-1 siRNA, there was a decrease in the Th22 cell proportion, mRNA and protein expression of HES-1, AHR, and IL-22.	dapt	96-100	aryl hydrocarbon receptor	Homo sapiens	205-208
33622250-10	2021	On the other hand, after the combined cytokine treatment of cells, and exposure to jagged-1 and DAPT or HES-1 siRNA, there was a decrease in the Th22 cell proportion, mRNA and protein expression of HES-1, AHR, and IL-22.	dapt	96-100	interleukin 22	Homo sapiens	214-219
33584186-5	2021	DAPT was intraperitoneally injected to down-regulate Notch-1 expression.	dapt	0-4	notch receptor 1	Rattus norvegicus	53-60
33513361-2	2021	We previously reported the efficient generation of CDX2-expressing intestinal progenitor cells from embryonic stem cells (ESCs) using 6-bromoindirubin-3"-oxime (BIO) and (3,5-difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-butyl ester (DAPT) to treat definitive endodermal cells.	dapt	170-240	caudal type homeobox 2	Homo sapiens	51-55
33513361-2	2021	We previously reported the efficient generation of CDX2-expressing intestinal progenitor cells from embryonic stem cells (ESCs) using 6-bromoindirubin-3"-oxime (BIO) and (3,5-difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-butyl ester (DAPT) to treat definitive endodermal cells.	dapt	242-246	caudal type homeobox 2	Homo sapiens	51-55
32980561-7	2021	JAG1 upregulated expression of multiple NOTCH canonical pathway genes (Hes1), which were downregulated in the presence of DAPT.	dapt	122-126	jagged 1	Mus musculus	0-4
32980561-7	2021	JAG1 upregulated expression of multiple NOTCH canonical pathway genes (Hes1), which were downregulated in the presence of DAPT.	dapt	122-126	hes family bHLH transcription factor 1	Homo sapiens	71-75
32980561-10	2021	Pathway analysis of JAG1+DAPT-treated CNC cells revealed significant upregulation of multiple non-canonical pathways, including the cell cycle, tubulin pathway, regulators of Runx2 initiation and phosphorylation of STAT5 pathway.	dapt	25-29	jagged 1	Mus musculus	20-24
32980561-10	2021	Pathway analysis of JAG1+DAPT-treated CNC cells revealed significant upregulation of multiple non-canonical pathways, including the cell cycle, tubulin pathway, regulators of Runx2 initiation and phosphorylation of STAT5 pathway.	dapt	25-29	RUNX family transcription factor 2	Homo sapiens	175-180
32980561-10	2021	Pathway analysis of JAG1+DAPT-treated CNC cells revealed significant upregulation of multiple non-canonical pathways, including the cell cycle, tubulin pathway, regulators of Runx2 initiation and phosphorylation of STAT5 pathway.	dapt	25-29	signal transducer and activator of transcription 5A	Homo sapiens	215-220
32701650-5	2021	Microinjection of DAPT, a gamma-secretase (a key enzyme involved in Notch pathway) inhibitor, into ACC significantly reversed neuropathic pain behaviors.	dapt	18-22	notch receptor 1	Rattus norvegicus	68-73
33045308-7	2021	Inhibition of the Notch signaling by Notch response inhibitor DAPT significantly down-regulated the expression of Shh signaling molecules, whereas exogenous rShh reversed the inhibition of C2C12 cells proliferative activity induced by DAPT, indicating Notch signaling act upstream of the Shh pathway.	dapt	62-66	sonic hedgehog	Mus musculus	114-117
33045308-7	2021	Inhibition of the Notch signaling by Notch response inhibitor DAPT significantly down-regulated the expression of Shh signaling molecules, whereas exogenous rShh reversed the inhibition of C2C12 cells proliferative activity induced by DAPT, indicating Notch signaling act upstream of the Shh pathway.	dapt	235-239	sonic hedgehog	Mus musculus	158-161
33468121-17	2021	RESV partly rescued the DAPT or Notch1 siRNA induced apoptosis by activating Notch1 signaling.	dapt	24-28	notch receptor 1	Homo sapiens	77-83
32535942-9	2020	Indeed, ALPL expression occurred concurrently with Notch activation and inhibiting Notch activity for up to 24 hours after BMP administration with DAPT (a gamma secretase inhibitor) completely abrogated hMSC osteoblastogenesis.	dapt	147-151	alkaline phosphatase, biomineralization associated	Homo sapiens	8-12
33248474-0	2020	Choosing between aspirin or P2Y12 monotherapy after short course of DAPT.	dapt	68-72	purinergic receptor P2Y12	Homo sapiens	28-33
32828943-8	2020	NOTCH1 inhibitor (DAPT) was used to explore the mechanism of ranolazine.	dapt	18-22	notch receptor 1	Rattus norvegicus	0-6
32828943-12	2020	Ranolazine-induced NOTCH1 activated NRG1 and inhibited the downstream apoptosis-related pathway, while DAPT partially inhibited ranolazine-induced NOTCH1 and NRG1 expression.	dapt	103-107	notch receptor 1	Rattus norvegicus	147-153
32828943-12	2020	Ranolazine-induced NOTCH1 activated NRG1 and inhibited the downstream apoptosis-related pathway, while DAPT partially inhibited ranolazine-induced NOTCH1 and NRG1 expression.	dapt	103-107	neuregulin 1	Rattus norvegicus	158-162
33095377-8	2021	In BV-2 microglia treated with a gamma-secretase inhibitor of Notch pathway- DAPT, the expression of RBP-JK, Hes-1, and NICD was suppressed in activated microglia.	dapt	77-81	notch receptor 1	Rattus norvegicus	62-67
33095377-8	2021	In BV-2 microglia treated with a gamma-secretase inhibitor of Notch pathway- DAPT, the expression of RBP-JK, Hes-1, and NICD was suppressed in activated microglia.	dapt	77-81	hes family bHLH transcription factor 1	Rattus norvegicus	109-114
33095377-9	2021	Treatment with DAPT and gastrodin further decreased NICD and Hes-1 expression.	dapt	15-19	hes family bHLH transcription factor 1	Rattus norvegicus	61-66
33095377-10	2021	Sirt3 expression was also decreased after DAPT treatment.	dapt	42-46	sirtuin 3	Rattus norvegicus	0-5
33095377-11	2021	However, Sirt3 expression in activated BV-2 microglia given a combined DAPT and gastrodin treatment was not further increased.	dapt	71-75	sirtuin 3	Rattus norvegicus	9-14
33095377-12	2021	In addition, combination of DAPT and Gastrodin cumulatively decreased tumor necrosis factor-alpha (TNF-alpha) expression.	dapt	28-32	tumor necrosis factor	Rattus norvegicus	70-97
33095377-12	2021	In addition, combination of DAPT and Gastrodin cumulatively decreased tumor necrosis factor-alpha (TNF-alpha) expression.	dapt	28-32	tumor necrosis factor	Rattus norvegicus	99-108
33081033-6	2020	RNA-sequencing studies of HCC-1599 and MB-157 cells exposed to ATRA and DAPT and ATRA+DAPT demonstrate that the two compounds act on common gene sets, some of which belong to the NOTCH1 pathway.	dapt	72-76	notch receptor 1	Homo sapiens	179-185
33081033-6	2020	RNA-sequencing studies of HCC-1599 and MB-157 cells exposed to ATRA and DAPT and ATRA+DAPT demonstrate that the two compounds act on common gene sets, some of which belong to the NOTCH1 pathway.	dapt	86-90	notch receptor 1	Homo sapiens	179-185
32945357-9	2020	Treatment with DAPT and BMS had opposite effects of Tbeta4, whereas Tbeta4 reversed the effect of DAPT and BMS.	dapt	15-19	transforming growth factor alpha regulated gene 3	Mus musculus	52-58
32945357-9	2020	Treatment with DAPT and BMS had opposite effects of Tbeta4, whereas Tbeta4 reversed the effect of DAPT and BMS.	dapt	98-102	transforming growth factor alpha regulated gene 3	Mus musculus	68-74
33456573-14	2021	Loss of lipin 1 function in zebrafish and mammalian cells also exhibited altered expression levels of muscle and neuron markers, as well as abnormally enhanced Notch signaling, which was partially rescued by the specific Notch pathway inhibitor DAPT.	dapt	245-249	lipin 1a	Danio rerio	8-15
32323420-0	2020	DAPT inhibits titanium particle-induced osteolysis by suppressing the RANKL/Notch2 signaling pathway.	dapt	0-4	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	70-75
32323420-0	2020	DAPT inhibits titanium particle-induced osteolysis by suppressing the RANKL/Notch2 signaling pathway.	dapt	0-4	notch 2	Mus musculus	76-82
32323420-6	2020	The aim of this study is to assess the effects of gamma-secretase inhibitor DAPT on osteoclastogenesis via Notch signaling pathway in vitro and titanium particle-induced osteolysis in vivo.	dapt	76-80	notch 2	Mus musculus	107-112
32323420-10	2020	DAPT inhibited the formation and function of osteoclast by blocking RANKL-induced Notch2-NF-kappaB complex signaling pathway.	dapt	0-4	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	68-73
32323420-10	2020	DAPT inhibited the formation and function of osteoclast by blocking RANKL-induced Notch2-NF-kappaB complex signaling pathway.	dapt	0-4	notch 2	Mus musculus	82-88
32853627-3	2020	In the present study, we sought to assess whether combining LXR ligand agonists (T317) with Notch receptor inhibitors (DAPT) would lead to enhanced anti-atherosclerotic activity while overcoming the adverse events associated with LXR ligand agonist therapy.	dapt	119-123	nuclear receptor subfamily 1, group H, member 3	Mus musculus	230-233
32853627-5	2020	The results of this analysis suggested that DAPT was able to improve the anti-atherosclerotic activity of T317 without reducing the stability of lesion plaques while simultaneously reducing blood lipids in treated ApoE-/- mice.	dapt	44-48	apolipoprotein E	Mus musculus	214-218
32853627-6	2020	This combination T317 + DAPT treatment was also linked with a significant upregulation of ABCA1 and the stimulation of reverse cholesterol transport (RCT), as well as with decreases in the levels of intercellular cell adhesion molecule-1 (ICAM-1) and p-p65, and with altered M1/M2 macrophage proportions within atherosclerotic plaques.	dapt	24-28	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	90-95
32853627-6	2020	This combination T317 + DAPT treatment was also linked with a significant upregulation of ABCA1 and the stimulation of reverse cholesterol transport (RCT), as well as with decreases in the levels of intercellular cell adhesion molecule-1 (ICAM-1) and p-p65, and with altered M1/M2 macrophage proportions within atherosclerotic plaques.	dapt	24-28	intercellular adhesion molecule 1	Mus musculus	199-237
32853627-6	2020	This combination T317 + DAPT treatment was also linked with a significant upregulation of ABCA1 and the stimulation of reverse cholesterol transport (RCT), as well as with decreases in the levels of intercellular cell adhesion molecule-1 (ICAM-1) and p-p65, and with altered M1/M2 macrophage proportions within atherosclerotic plaques.	dapt	24-28	intercellular adhesion molecule 1	Mus musculus	239-245
32853627-6	2020	This combination T317 + DAPT treatment was also linked with a significant upregulation of ABCA1 and the stimulation of reverse cholesterol transport (RCT), as well as with decreases in the levels of intercellular cell adhesion molecule-1 (ICAM-1) and p-p65, and with altered M1/M2 macrophage proportions within atherosclerotic plaques.	dapt	24-28	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	253-256
32853627-7	2020	Importantly, DAPT was also able to reduce T317-mediated lipid accumulation within the liver owing to its ability to reduce SREBP-1 expression while simultaneously increasing that of Pi-AMPKalpha and PPARalpha.	dapt	13-17	sterol regulatory element binding transcription factor 1	Mus musculus	123-130
32853627-7	2020	Importantly, DAPT was also able to reduce T317-mediated lipid accumulation within the liver owing to its ability to reduce SREBP-1 expression while simultaneously increasing that of Pi-AMPKalpha and PPARalpha.	dapt	13-17	peroxisome proliferator activated receptor alpha	Mus musculus	199-208
32535942-9	2020	Indeed, ALPL expression occurred concurrently with Notch activation and inhibiting Notch activity for up to 24 hours after BMP administration with DAPT (a gamma secretase inhibitor) completely abrogated hMSC osteoblastogenesis.	dapt	147-151	bone morphogenetic protein 1	Homo sapiens	123-126
32933345-5	2021	The protein expression levels of Jaggedl, Notchl, pro-caspase-3, Drpl, and PGC-1alpha were increased by high glucose, but N-[N-(3,5-difluorohenacetyl)-l-alanyl]-S-phenylglycine tert-butyl ester (DAPT; an inhibitor of the Notch signaling pathway) reversed these effects.	dapt	195-199	PPARG coactivator 1 alpha	Sus scrofa	75-85
33162798-9	2020	In addition, pharmacological Notch signal inhibition with DAPT induced apoptosis in aortic SMCs.	dapt	58-62	notch receptor 1	Rattus norvegicus	29-34
32933345-6	2021	Furthermore, DAPT reduced the mRNA expression of Jaggedl, Notchl, MnSOD2, Drpl, and PGC-1alpha in renal tubular epithelial cells induced by high glucose.	dapt	13-17	PPARG coactivator 1 alpha	Sus scrofa	84-94
32490531-10	2020	DAPT also significantly increased the expression of anti-inflammatory genes, including c-Myc, Egr2, and Arg1 at 12-24 h in the LPS-stimulated macrophages (P<0.05).	dapt	0-4	arginase, liver	Mus musculus	104-108
33013850-5	2020	We inhibited the secretion of Abeta peptides in primary human monocyte derived macrophages with the gamma-secretase inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine-t-butyl-ester (DAPT) or the beta-secretase inhibitor GL-189.	dapt	197-201	amyloid beta precursor protein	Homo sapiens	30-35
32770090-10	2020	DAPT treatment significantly promoted TWIST1, but decreased ALP, mRNA expression, compared with the control.	dapt	0-4	twist family bHLH transcription factor 1	Homo sapiens	38-44
32770090-10	2020	DAPT treatment significantly promoted TWIST1, but decreased ALP, mRNA expression, compared with the control.	dapt	0-4	ATHS	Homo sapiens	60-63
32952360-5	2020	N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), an inhibitor of gamma-secretase, was used to modulate the Notch-2 signaling pathway.	dapt	0-69	notch receptor 2	Rattus norvegicus	136-143
32952360-5	2020	N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), an inhibitor of gamma-secretase, was used to modulate the Notch-2 signaling pathway.	dapt	71-75	notch receptor 2	Rattus norvegicus	136-143
32952360-7	2020	DAPT inhibited Notch-2 signal to abolish the expressions of fibronectin and collagen I in VSMCs, and also prevented the proliferation/migration of VSMCs under high glucose (D-glucose 25 mM) stress.	dapt	0-4	notch receptor 2	Rattus norvegicus	15-22
32952360-7	2020	DAPT inhibited Notch-2 signal to abolish the expressions of fibronectin and collagen I in VSMCs, and also prevented the proliferation/migration of VSMCs under high glucose (D-glucose 25 mM) stress.	dapt	0-4	fibronectin 1	Rattus norvegicus	60-71
32490531-5	2020	Progressive increase in aortic stiffness and maximal intraluminal diameter (MILD) was observed in the AngII + vehicle group, which was significantly prevented by DAPT (P<0.01).	dapt	162-166	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	102-107
32169443-12	2020	DAPT counteracted the effects of Notch-1 activation on PCNA and IL-33.	dapt	0-4	notch receptor 1	Homo sapiens	33-40
32490531-6	2020	The regression of aneurysm with DAPT was associated with reduced F4/80+Cd68+ (cluster of differentiation 68) inflammatory macrophages.	dapt	32-36	adhesion G protein-coupled receptor E1	Mus musculus	65-70
32490531-8	2020	Mechanistically, C-C chemokine receptor type 7 (Ccr7)+F4/80- dendritic cells (DCs), implicated in the regression of aneurysm, were increased in the aorta of DAPT-treated mice.	dapt	157-161	chemokine (C-C motif) receptor 7	Mus musculus	17-46
32490531-8	2020	Mechanistically, C-C chemokine receptor type 7 (Ccr7)+F4/80- dendritic cells (DCs), implicated in the regression of aneurysm, were increased in the aorta of DAPT-treated mice.	dapt	157-161	chemokine (C-C motif) receptor 7	Mus musculus	48-52
32490531-8	2020	Mechanistically, C-C chemokine receptor type 7 (Ccr7)+F4/80- dendritic cells (DCs), implicated in the regression of aneurysm, were increased in the aorta of DAPT-treated mice.	dapt	157-161	adhesion G protein-coupled receptor E1	Mus musculus	54-59
32490531-9	2020	In the macrophages stimulated with AngII or lipopolysaccharide (LPS), DAPT reverted the expression of pro-inflammatory genes Il6 and Il12 back to baseline within 6 h compared with vehicle (P<0.05).	dapt	70-74	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	35-40
32490531-9	2020	In the macrophages stimulated with AngII or lipopolysaccharide (LPS), DAPT reverted the expression of pro-inflammatory genes Il6 and Il12 back to baseline within 6 h compared with vehicle (P<0.05).	dapt	70-74	interleukin 6	Mus musculus	125-128
32490531-10	2020	DAPT also significantly increased the expression of anti-inflammatory genes, including c-Myc, Egr2, and Arg1 at 12-24 h in the LPS-stimulated macrophages (P<0.05).	dapt	0-4	early growth response 2	Mus musculus	94-98
32546185-14	2020	After stimulation of mDCs with recombinant Jagged1, DCs with low expression of MHCII, CD86 and CD40 were also induced, and the effects of both rhJagged1 and MSCs on DCs were blocked by the Notch inhibitor DAPT.	dapt	205-209	jagged 1	Mus musculus	43-50
32546185-14	2020	After stimulation of mDCs with recombinant Jagged1, DCs with low expression of MHCII, CD86 and CD40 were also induced, and the effects of both rhJagged1 and MSCs on DCs were blocked by the Notch inhibitor DAPT.	dapt	205-209	notch 2	Mus musculus	189-194
32695658-5	2020	In A375 with B-raf mutation, DAPT decreased the level of NOTCH1, NOTH2, and HES1 as downstream genes of the Notch pathway.	dapt	29-33	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	13-18
32695658-5	2020	In A375 with B-raf mutation, DAPT decreased the level of NOTCH1, NOTH2, and HES1 as downstream genes of the Notch pathway.	dapt	29-33	notch receptor 1	Homo sapiens	57-63
32695658-5	2020	In A375 with B-raf mutation, DAPT decreased the level of NOTCH1, NOTH2, and HES1 as downstream genes of the Notch pathway.	dapt	29-33	hes family bHLH transcription factor 1	Homo sapiens	76-80
32695658-5	2020	In A375 with B-raf mutation, DAPT decreased the level of NOTCH1, NOTH2, and HES1 as downstream genes of the Notch pathway.	dapt	29-33	notch receptor 1	Homo sapiens	108-113
32695658-11	2020	Our data supported that the long-term and not short-term inhibition of Notch by DAPT may enhance tumor growth and motility through up-regulation of AXIN1, CSNK2A3, and CEBPA2 genes in B-raf mutated A375 cells.	dapt	80-84	notch receptor 1	Homo sapiens	71-76
32695658-11	2020	Our data supported that the long-term and not short-term inhibition of Notch by DAPT may enhance tumor growth and motility through up-regulation of AXIN1, CSNK2A3, and CEBPA2 genes in B-raf mutated A375 cells.	dapt	80-84	axin 1	Homo sapiens	148-153
32695658-11	2020	Our data supported that the long-term and not short-term inhibition of Notch by DAPT may enhance tumor growth and motility through up-regulation of AXIN1, CSNK2A3, and CEBPA2 genes in B-raf mutated A375 cells.	dapt	80-84	casein kinase 2 alpha 3	Homo sapiens	155-162
32695658-11	2020	Our data supported that the long-term and not short-term inhibition of Notch by DAPT may enhance tumor growth and motility through up-regulation of AXIN1, CSNK2A3, and CEBPA2 genes in B-raf mutated A375 cells.	dapt	80-84	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	184-189
32151947-12	2020	Genetic and pharmacological Notch pathway inhibition by DAPT and Notch-1 siRNA exhibited decreased curcumin mediated neuroprotection.	dapt	56-60	notch receptor 1	Homo sapiens	28-33
32169443-12	2020	DAPT counteracted the effects of Notch-1 activation on PCNA and IL-33.	dapt	0-4	proliferating cell nuclear antigen	Homo sapiens	55-59
32169443-12	2020	DAPT counteracted the effects of Notch-1 activation on PCNA and IL-33.	dapt	0-4	interleukin 33	Homo sapiens	64-69
32239181-11	2020	And Notch inhibitor (DAPT) counteracted the the impact of over-expressing STYX on cell proliferation and cell apoptosis.	dapt	21-25	serine/threonine/tyrosine interacting protein	Homo sapiens	74-78
32523457-2	2020	The availability of different P2Y12 inhibitors set the stage for costum made DAPT, as to achieve the highest profile of safety and efficacy.	dapt	77-81	purinergic receptor P2Y12	Homo sapiens	30-35
32323401-5	2020	Treatment of mice with DAPT, an inhibitor of the Notch pathway, decreased the expression of Cx37, and partially mimicked in WT retinas, the alterations observed in Cx37-/- mice.	dapt	23-27	gap junction protein, alpha 4	Mus musculus	92-96
32323401-5	2020	Treatment of mice with DAPT, an inhibitor of the Notch pathway, decreased the expression of Cx37, and partially mimicked in WT retinas, the alterations observed in Cx37-/- mice.	dapt	23-27	gap junction protein, alpha 4	Mus musculus	164-168
32173531-9	2020	Importantly, DAPT enhanced the apoptosis rate of VIN- and 5-FU-treated CD133+ cells for 3- and 2-fold, which was correlated with the enhanced expression of pro-apoptotic BBC3 (BCL-2-binding component 3) and decreased expression of HES1 that was reported to regulate BBC3 negatively.	dapt	13-17	BCL2 binding component 3	Homo sapiens	170-174
32173531-9	2020	Importantly, DAPT enhanced the apoptosis rate of VIN- and 5-FU-treated CD133+ cells for 3- and 2-fold, which was correlated with the enhanced expression of pro-apoptotic BBC3 (BCL-2-binding component 3) and decreased expression of HES1 that was reported to regulate BBC3 negatively.	dapt	13-17	BCL2 binding component 3	Homo sapiens	176-201
32173531-9	2020	Importantly, DAPT enhanced the apoptosis rate of VIN- and 5-FU-treated CD133+ cells for 3- and 2-fold, which was correlated with the enhanced expression of pro-apoptotic BBC3 (BCL-2-binding component 3) and decreased expression of HES1 that was reported to regulate BBC3 negatively.	dapt	13-17	hes family bHLH transcription factor 1	Homo sapiens	231-235
32173531-9	2020	Importantly, DAPT enhanced the apoptosis rate of VIN- and 5-FU-treated CD133+ cells for 3- and 2-fold, which was correlated with the enhanced expression of pro-apoptotic BBC3 (BCL-2-binding component 3) and decreased expression of HES1 that was reported to regulate BBC3 negatively.	dapt	13-17	BCL2 binding component 3	Homo sapiens	266-270
32384926-11	2020	In addition, we demonstrated that blocking Notch pathway with DAPT could restore the phenotype of METTL3 deficient endothelial cells.	dapt	62-66	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	98-104
32482162-9	2020	Presence of Notch signaling activity was confirmed through nuclear NICD and Hes1 detection, and downregulation of Hes1 transcription following canonical signaling blockade with DAPT.	dapt	177-181	notch 1	Mus musculus	12-17
32482162-9	2020	Presence of Notch signaling activity was confirmed through nuclear NICD and Hes1 detection, and downregulation of Hes1 transcription following canonical signaling blockade with DAPT.	dapt	177-181	hes family bHLH transcription factor 1	Mus musculus	114-118
32482162-12	2020	Notch signaling blockade by DAPT downregulated transcription of Sox2, and retarded embryo hatching.	dapt	28-32	notch 1	Mus musculus	0-5
32482162-12	2020	Notch signaling blockade by DAPT downregulated transcription of Sox2, and retarded embryo hatching.	dapt	28-32	SRY (sex determining region Y)-box 2	Mus musculus	64-68
32601154-10	2020	Inhibition of RAGE and Notch1 by FPS-ZM1 (N-Benzyl-4-chloro-N-cyclohexylbenzamide) and DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenyl glycine t-butylester), respectively, abrogates AGE-induced Notch activation and EMT.	dapt	87-91	advanced glycosylation end product-specific receptor	Mus musculus	14-18
32601154-10	2020	Inhibition of RAGE and Notch1 by FPS-ZM1 (N-Benzyl-4-chloro-N-cyclohexylbenzamide) and DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenyl glycine t-butylester), respectively, abrogates AGE-induced Notch activation and EMT.	dapt	87-91	notch receptor 1	Homo sapiens	23-28
32601154-14	2020	Pharmacological inhibition of Notch signaling by DAPT ameliorates AGE-induced podocytopathy and fibrosis.	dapt	49-53	notch receptor 1	Homo sapiens	30-35
32454795-9	2020	In vitro study demonstrated that DAPT treatment could result in dose-dependent decrease of IL-17A+ gammadelta +T cell percentage and IL-17A secretion in splenic single cells of model mice.	dapt	33-37	interleukin 17A	Mus musculus	91-97
32454795-9	2020	In vitro study demonstrated that DAPT treatment could result in dose-dependent decrease of IL-17A+ gammadelta +T cell percentage and IL-17A secretion in splenic single cells of model mice.	dapt	33-37	interleukin 17A	Mus musculus	133-139
32319581-10	2020	The Notch-1 signaling pathway was activated to induce EMT in forskolin-induced VM process in CC cells, and VM and EMT could be reversed by using the gamma-secretase inhibitor DAPT to block the Notch-1 pathway.	dapt	175-179	notch receptor 1	Homo sapiens	4-11
32319581-10	2020	The Notch-1 signaling pathway was activated to induce EMT in forskolin-induced VM process in CC cells, and VM and EMT could be reversed by using the gamma-secretase inhibitor DAPT to block the Notch-1 pathway.	dapt	175-179	notch receptor 1	Homo sapiens	193-200
31549178-1	2020	Dual antiplatelet therapy (DAPT) with aspirin and P2Y12 inhibitor is administered following percutaneous coronary intervention (PCI) with coronary stent implantation.	dapt	27-31	purinergic receptor P2Y12	Homo sapiens	50-55
32313117-3	2020	Gene expression analysis revealed that DAPT severely down-regulates PTGER2, which encodes prostaglandin (PG) E2 receptor 2 (EP2), in human muscle progenitors in the differentiation condition.	dapt	39-43	prostaglandin E receptor 2	Homo sapiens	68-74
32313117-3	2020	Gene expression analysis revealed that DAPT severely down-regulates PTGER2, which encodes prostaglandin (PG) E2 receptor 2 (EP2), in human muscle progenitors in the differentiation condition.	dapt	39-43	prostaglandin E receptor 2	Homo sapiens	109-122
32313117-3	2020	Gene expression analysis revealed that DAPT severely down-regulates PTGER2, which encodes prostaglandin (PG) E2 receptor 2 (EP2), in human muscle progenitors in the differentiation condition.	dapt	39-43	prostaglandin E receptor 2	Homo sapiens	124-127
31828756-1	2020	BACKGROUND: Patients presenting with acute coronary syndromes (ACS) are often treated by percutaneous coronary intervention (PCI) with insertion of coronary artery stents and a majority receive dual antiplatelet therapy (DAPT), usually a combination of a COX-1 inhibitor (aspirin) and a P2Y12 inhibitor (eg ticagrelor).	dapt	221-225	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	255-260
31828756-1	2020	BACKGROUND: Patients presenting with acute coronary syndromes (ACS) are often treated by percutaneous coronary intervention (PCI) with insertion of coronary artery stents and a majority receive dual antiplatelet therapy (DAPT), usually a combination of a COX-1 inhibitor (aspirin) and a P2Y12 inhibitor (eg ticagrelor).	dapt	221-225	purinergic receptor P2Y12	Homo sapiens	287-292
32157565-6	2020	Two chemical drugs, 2,3-Bis(4-hydroxyphenyl)-propionitrile (DPN) and N-[N-(3,5-difluorophenacetyl)-l-alanyl]-s-phenylglycine t-butyl ester (DAPT), a specific inhibitor of Notch1 signalling) were administered via intraperitoneal injection to change oestrogen receptor beta and Notch1 activities.	dapt	69-138	notch 1	Mus musculus	171-177
32157565-11	2020	Nevertheless, all of these cardioprotective effects of oestrogen receptor beta activation were almost abrogated by DAPT administration, i.e. DAPT attenuated the anti-oxidative and anti-apoptotic effects and the decrease in infarct and fibrotic areas and reversed cardiac functional recovery.	dapt	115-119	estrogen receptor 2 (beta)	Mus musculus	55-78
32157565-11	2020	Nevertheless, all of these cardioprotective effects of oestrogen receptor beta activation were almost abrogated by DAPT administration, i.e. DAPT attenuated the anti-oxidative and anti-apoptotic effects and the decrease in infarct and fibrotic areas and reversed cardiac functional recovery.	dapt	141-145	estrogen receptor 2 (beta)	Mus musculus	55-78
31527287-4	2020	Blocking of the notch signaling pathway (NSP) either by Notch1 siRNA or by DAPT treatment increased the proliferation rate while decreasing apoptosis and led to activation of the NF-kappaB signaling pathway in HSCs co-cultured with BMSCs.	dapt	75-79	notch receptor 1	Homo sapiens	16-21
32124868-8	2020	DAPT was applied during 72.12% of interventions: in 49.68% of interventions, the purinergic signaling receptor Y12 (P2Y12) inhibitor used was clopidogrel and in 25.14% of interventions ticagrelor was used (P<0.001).	dapt	0-4	purinergic receptor P2Y12	Homo sapiens	116-121
32157565-12	2020	The levels of phospho-phosphatidylinositol-3-kinase (PI3K) and phospho-protein kinase B (Akt) were increased after DPN administration, and this change was reversed after DAPT was administered.	dapt	170-174	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	14-51
32157565-12	2020	The levels of phospho-phosphatidylinositol-3-kinase (PI3K) and phospho-protein kinase B (Akt) were increased after DPN administration, and this change was reversed after DAPT was administered.	dapt	170-174	thymoma viral proto-oncogene 1	Mus musculus	89-92
31883679-5	2020	Similarly, in patients identified as high risk by DAPT, 55% had high platelet FcgammaRIIa expression.	dapt	50-54	Fc gamma receptor IIa	Homo sapiens	78-89
31883679-6	2020	High platelet FcgammaRIIa expression discriminated high and low risk cohorts in patients with high cardiovascular risk defined by either the GRACE score (high platelet FcgammaRIIa 18.9% vs low platelet FcgammaRIIa 0%; odds ratio = 15.7, p = 0.06) or the DAPT score (high platelet FcgammaRIIa 15.4% vs low platelet FcgammaRIIa 3.7%; odds ratio = 5.6, p = 0.03) assessment.	dapt	254-258	Fc gamma receptor IIa	Homo sapiens	14-25
32116749-9	2020	We also demonstrated a 3-fold induction (p < 0.001) of human coronary VSMC Notch signaling by ECs at the in vitro MEJ, which was completely blocked by the Notch inhibitor, DAPT (p < 0.01).	dapt	172-176	notch receptor 1	Homo sapiens	75-80
32116749-9	2020	We also demonstrated a 3-fold induction (p < 0.001) of human coronary VSMC Notch signaling by ECs at the in vitro MEJ, which was completely blocked by the Notch inhibitor, DAPT (p < 0.01).	dapt	172-176	notch receptor 1	Homo sapiens	155-160
31051269-3	2020	Our screen yielded DAPT, a Notch signaling inhibitor that could ameliorate the craniofacial, cranial neuronal and myelination defects in chd7 morphant zebrafish embryos.	dapt	19-23	chromodomain helicase DNA binding protein 7	Danio rerio	137-141
31504280-8	2020	Knockdown of Hes1 or treatment with Notch signal inhibitor DAPT recovers the ACD defect in the Pdk1 cKO.	dapt	59-63	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	95-99
31863921-0	2020	DAPT reverses the Th17/Treg imbalance in experimental autoimmune uveitis in vitro via inhibiting Notch signaling pathway.	dapt	0-4	notch receptor 1	Homo sapiens	97-102
31863921-7	2020	By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance.	dapt	46-50	notch receptor 1	Homo sapiens	27-32
31863921-7	2020	By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance.	dapt	46-50	notch receptor 1	Homo sapiens	127-133
31863921-7	2020	By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance.	dapt	46-50	delta like canonical Notch ligand 4	Homo sapiens	135-139
31863921-7	2020	By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance.	dapt	46-50	interleukin 17A	Homo sapiens	141-146
31863921-7	2020	By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance.	dapt	46-50	CD4 molecule	Homo sapiens	218-221
31863921-7	2020	By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance.	dapt	46-50	CD8a molecule	Homo sapiens	223-226
31974606-7	2020	DAPT-treated diabetic rats demonstrated mitigated renal injury and function, antioxidative activity was significantly improved and HIF-1a was upregulated.	dapt	0-4	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	131-137
31974606-8	2020	Notch inhibitor DAPT is a potential therapeutic target to improve the outcome of RI/RI in STZ-induced diabetic rats in part via the regulation of anti-oxidation and HIF-1a.	dapt	16-20	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	165-171
31894345-8	2020	Compared with the control group, there was significantly increased miR-449a expression in the miR-449a mimic group, and there was significantly decreased expression of Notch1, Jagged1, PCNA, MMP-2, MMP-9 and Bcl-2, increased Bax, reduced cell proliferation, increased G1-phase cell fraction, decreased S-phase cell fraction, an increased apoptosis rate, and decreased invasion ability in the miR-449a mimic group and DAPT group (all P<0.05).	dapt	417-421	microRNA 449a	Homo sapiens	94-102
31894345-8	2020	Compared with the control group, there was significantly increased miR-449a expression in the miR-449a mimic group, and there was significantly decreased expression of Notch1, Jagged1, PCNA, MMP-2, MMP-9 and Bcl-2, increased Bax, reduced cell proliferation, increased G1-phase cell fraction, decreased S-phase cell fraction, an increased apoptosis rate, and decreased invasion ability in the miR-449a mimic group and DAPT group (all P<0.05).	dapt	417-421	microRNA 449a	Homo sapiens	94-102
31957832-0	2020	Inhibitory effect of the Notch pathway-inhibitor DAPT on invasion and metastasis of tongue cancer via lncRNA-KAT14 regulation.	dapt	49-53	lysine acetyltransferase 14	Homo sapiens	109-114
31957832-7	2020	RESULTS: Proliferation was inhibited after treatment with DAPT, and the expression of lncRNA-KAT14 was upregulated.	dapt	58-62	lysine acetyltransferase 14	Homo sapiens	93-98
31957832-3	2020	Further, qRT-PCR was used to determine the mRNA expression levels of lncRNA-KAT14 after treatment with DAPT or si-KAT14 and both combined.	dapt	103-107	lysine acetyltransferase 14	Homo sapiens	76-81
31957832-10	2020	Once transfection with si-KAT14 occurred, the evaluated cellular processes were enhanced, being this attenuated by the treatment with DAPT.	dapt	134-138	lysine acetyltransferase 14	Homo sapiens	26-31
31957832-11	2020	CONCLUSIONS: Our results suggest that DAPT suppresses invasion and metastasis of tongue cancer by regulating lncRNA-KAT14.	dapt	38-42	lysine acetyltransferase 14	Homo sapiens	116-121
31933687-3	2019	AIM: To assess the cost-effectiveness of guided DAPT with clopidogrel or ticagrelor in addition to aspirin when using VerifyNow P2Y12 testing in post-ACS patients.	dapt	48-52	purinergic receptor P2Y12	Homo sapiens	128-133
31476403-10	2019	In addition, the defensive functions of PHC on LPS-activated NR8383 alveolar macrophages were abrogated through the Notch1 pathway antagonist [(3,5-difluorophenacetyl)-1-alanyl] -phenylglycine-butyl ester (DAPT).	dapt	206-210	notch receptor 1	Rattus norvegicus	116-122
31347026-7	2020	Notch-1 signaling inhibition, through intrathecal administration of the gamma-secretase inhibitor, DAPT, counteracted PKC and ERK overphosphorylation, MOR internalization, and analgesic tolerance.	dapt	99-103	notch 1	Mus musculus	0-7
31347026-7	2020	Notch-1 signaling inhibition, through intrathecal administration of the gamma-secretase inhibitor, DAPT, counteracted PKC and ERK overphosphorylation, MOR internalization, and analgesic tolerance.	dapt	99-103	mitogen-activated protein kinase 1	Mus musculus	126-129
31347026-7	2020	Notch-1 signaling inhibition, through intrathecal administration of the gamma-secretase inhibitor, DAPT, counteracted PKC and ERK overphosphorylation, MOR internalization, and analgesic tolerance.	dapt	99-103	opioid receptor, mu 1	Mus musculus	151-154
31933687-8	2019	CONCLUSION: Assessment of heightened residual platelet reactivity with P2Y12 assay in triaging DAPT post-ACS patients for 1 year is a cost-effective strategy that would reduce financial burden compared to routine administration of more expensive antiplatelet agents.	dapt	95-99	purinergic receptor P2Y12	Homo sapiens	71-76
31297750-5	2019	CD4+ T cells were treated with DAPT or PI and harvested after 72 h. PKCtheta inhibition markedly attenuated pathological changes and decreased the wet to dry weight ratio of the mouse lungs.	dapt	31-35	CD4 antigen	Mus musculus	0-3
30957572-3	2019	Given the significant role of Notch-EGFR interplay in raising severe resistance to EGFR inhibition of EB, gamma secretase inhibitor (GSI)-DAPT was further entrapped into the core of nanoparticles to inhibit the activation of Notch signaling (NP-EB/DART).	dapt	138-142	epidermal growth factor receptor	Homo sapiens	36-40
30957572-3	2019	Given the significant role of Notch-EGFR interplay in raising severe resistance to EGFR inhibition of EB, gamma secretase inhibitor (GSI)-DAPT was further entrapped into the core of nanoparticles to inhibit the activation of Notch signaling (NP-EB/DART).	dapt	138-142	epidermal growth factor receptor	Homo sapiens	83-87
31297750-5	2019	CD4+ T cells were treated with DAPT or PI and harvested after 72 h. PKCtheta inhibition markedly attenuated pathological changes and decreased the wet to dry weight ratio of the mouse lungs.	dapt	31-35	protein kinase C, theta	Mus musculus	68-76
31511328-5	2019	Pharmacological inhibition of Notch1 by gamma-secretase inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-l-alanyl]-S-phenyl glycine t-butylester) abrogates GH-induced epithelial to mesenchymal transition (EMT) and is associated with a reduction in podocyte loss.	dapt	66-70	notch 1	Mus musculus	30-36
30839137-10	2019	DAPT (the specific blocker of Notch1) and BMSC-conditioned medium (BMSC-CM) could significantly prevent the apoptotic effect and oxidative stress injury on NSCs that were treated with H2 O2 .	dapt	0-4	notch receptor 1	Homo sapiens	30-36
31515081-9	2019	Additionally, administration of DAPT induced a decrease in the expression of GATA-3 mRNA, however, no influence on T-bet mRNA production.	dapt	32-36	GATA binding protein 3	Homo sapiens	77-83
31471043-4	2019	Further reduction toward a 1-month DAPT is likely to involve new strategies of stopping aspirin at 1 month, and continuing long-term monotherapy with inhibitors of P2Y12 receptor.	dapt	35-39	purinergic receptor P2Y12	Homo sapiens	164-169
31471043-7	2019	Conversely, in patients who have fully tolerated a 12-month DAPT after infarction, and who are at very high risk of ischemic recurrence, the prolongation of a P2Y12 inhibitor in combination with aspirin may be considered, with a risk of haemorrhage almost double.	dapt	60-64	purinergic receptor P2Y12	Homo sapiens	159-164
31511328-5	2019	Pharmacological inhibition of Notch1 by gamma-secretase inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-l-alanyl]-S-phenyl glycine t-butylester) abrogates GH-induced epithelial to mesenchymal transition (EMT) and is associated with a reduction in podocyte loss.	dapt	66-70	growth hormone	Mus musculus	153-155
31511328-6	2019	More importantly, our results show that DAPT treatment blocks cytokine release and prevents glomerular fibrosis, all of which are induced by excess GH.	dapt	40-44	growth hormone	Mus musculus	148-150
31511328-7	2019	Furthermore, DAPT prevented glomerular basement membrane thickening and proteinuria induced by excess GH.	dapt	13-17	growth hormone	Mus musculus	102-104
31439713-4	2019	Sorafenib, and DNA intercalators lead to the enrichment of LCSCs while Rapamycin and DAPT significantly reduced CD133/EpCAM positivity.	dapt	85-89	prominin 1	Homo sapiens	112-117
31439713-4	2019	Sorafenib, and DNA intercalators lead to the enrichment of LCSCs while Rapamycin and DAPT significantly reduced CD133/EpCAM positivity.	dapt	85-89	epithelial cell adhesion molecule	Homo sapiens	118-123
31666602-7	2019	Then, Runx2 gene expression was interfered using lentivirus transfection (RNAi) and was over-expressed by plasmids transfected siRNA in chondrocytes, and MMP-13 expression was analyzed after Jagged-1/DAPT treatment.	dapt	200-204	RUNX family transcription factor 2	Rattus norvegicus	6-11
31666602-17	2019	Under IL-1beta circumstance, MMP-13 expression could be reduced by both DAPT treatment and Runx2 RNAi, while Runx2 interference also attenuated the "regulatory sensitivity" of Notch in MMP-13 under IL-1beta stimulation.	dapt	72-76	interleukin 1 alpha	Rattus norvegicus	6-14
31666602-17	2019	Under IL-1beta circumstance, MMP-13 expression could be reduced by both DAPT treatment and Runx2 RNAi, while Runx2 interference also attenuated the "regulatory sensitivity" of Notch in MMP-13 under IL-1beta stimulation.	dapt	72-76	matrix metallopeptidase 13	Rattus norvegicus	29-35
31666602-19	2019	In the meanwhile, DAPT treatment could effectively suppress expression of MMP-13 stimulated by IL-1 beta.	dapt	18-22	matrix metallopeptidase 13	Rattus norvegicus	74-80
31666602-19	2019	In the meanwhile, DAPT treatment could effectively suppress expression of MMP-13 stimulated by IL-1 beta.	dapt	18-22	interleukin 1 alpha	Rattus norvegicus	95-104