PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12021443-1	2002	Dihydrofolate reductase (DHFR) catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of 7,8-dihydrofolate (H2F) to 5,6,7,8-tetrahydrofolate (H4F).	tetrahydrafolate	173-176	Dihydrofolate reductase	Escherichia coli	0-23
29858389-2	2018	The hypothesis relates to the low affinity for cofactor of the PLP-dependent serine hydroxymethyl transferase (SHMT), the enzyme that catalyzes formation of CH2-H4PteGlu by transfer of the Cbeta of serine to H4PteGlu.	tetrahydrafolate	161-169	serine hydroxymethyltransferase 1	Homo sapiens	77-109
29858389-2	2018	The hypothesis relates to the low affinity for cofactor of the PLP-dependent serine hydroxymethyl transferase (SHMT), the enzyme that catalyzes formation of CH2-H4PteGlu by transfer of the Cbeta of serine to H4PteGlu.	tetrahydrafolate	161-169	serine hydroxymethyltransferase 1	Homo sapiens	111-115
21371789-1	2011	Serine hydroxymethyltransferase (SHMT), a ubiquitous representative of the family of fold-type I, pyridoxal 5"-phosphate (PLP) dependent enzymes, catalyzes the reversible conversion of tetrahydrofolate (H4PteGlu) and serine to 5,10-CH2-H4PteGlu and glycine.	tetrahydrafolate	203-211	serine hydroxymethyltransferase 1	Homo sapiens	0-31
21371789-1	2011	Serine hydroxymethyltransferase (SHMT), a ubiquitous representative of the family of fold-type I, pyridoxal 5"-phosphate (PLP) dependent enzymes, catalyzes the reversible conversion of tetrahydrofolate (H4PteGlu) and serine to 5,10-CH2-H4PteGlu and glycine.	tetrahydrafolate	203-211	serine hydroxymethyltransferase 1	Homo sapiens	33-37
21371789-7	2011	The results of this study showed that pemetrexed competitively inhibits SHMT with respect to H4PteGlu with a measured Ki of 19.1+-3.1 muM; this value was consistent with a Kd of 16.9+-5.0 muM, measured by isothermal titration calorimetry.	tetrahydrafolate	93-101	serine hydroxymethyltransferase 1	Homo sapiens	72-76
21371789-7	2011	The results of this study showed that pemetrexed competitively inhibits SHMT with respect to H4PteGlu with a measured Ki of 19.1+-3.1 muM; this value was consistent with a Kd of 16.9+-5.0 muM, measured by isothermal titration calorimetry.	tetrahydrafolate	93-101	latexin	Homo sapiens	134-137
12021443-1	2002	Dihydrofolate reductase (DHFR) catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of 7,8-dihydrofolate (H2F) to 5,6,7,8-tetrahydrofolate (H4F).	tetrahydrafolate	173-176	Dihydrofolate reductase	Escherichia coli	25-29
9572848-10	1998	Overall, the steady-state rate contains contributions from the product off rates from the DHFR.5,6, 7,8-tetrahydrofolate (H4F) and DHFR.NADPH.H4F complexes and from the rate of hydride transfer.	tetrahydrafolate	122-125	Dihydrofolate reductase	Escherichia coli	90-94
9572848-10	1998	Overall, the steady-state rate contains contributions from the product off rates from the DHFR.5,6, 7,8-tetrahydrofolate (H4F) and DHFR.NADPH.H4F complexes and from the rate of hydride transfer.	tetrahydrafolate	142-145	Dihydrofolate reductase	Escherichia coli	90-94
7646059-1	1995	10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate.	tetrahydrafolate	144-152	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	0-39
7646059-1	1995	10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate.	tetrahydrafolate	144-152	ferritin heavy chain 1	Rattus norvegicus	44-47
7646059-1	1995	10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate.	tetrahydrafolate	144-152	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	48-51
7646059-1	1995	10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate.	tetrahydrafolate	175-183	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	0-39
7646059-1	1995	10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate.	tetrahydrafolate	175-183	ferritin heavy chain 1	Rattus norvegicus	44-47
7646059-1	1995	10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate.	tetrahydrafolate	175-183	aldehyde dehydrogenase 1 family, member L1	Rattus norvegicus	48-51