PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8085710-6	1994	Nevertheless, some neuro-endocrine effects of BZD are mediated through actions on BZD receptors in the pituitary gland: we reported an inhibition of TRH induced PRL release by diazepam (treatment of 7 days) in anxious patients.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	46-49	thyrotropin releasing hormone	Homo sapiens	149-152
2906518-1	1988	In summary, 5HT, ACh, NE, E and DA appear to stimulate hypothalamic CRH secretion whereas activation of the GABA/BZD system seems to decrease the responsivity of the CRH neuron to stimulatory neurotransmitters (Fig.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	113-116	corticotropin releasing hormone	Rattus norvegicus	166-169
34464700-21	2021	Finally, Western blot showed that BZD dramatically reversed the suppression of PI3K/Akt/GSK-3beta pathway and the activation of MAPK pathway in CUMS mice model.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	34-37	thymoma viral proto-oncogene 1	Mus musculus	84-87
34464700-21	2021	Finally, Western blot showed that BZD dramatically reversed the suppression of PI3K/Akt/GSK-3beta pathway and the activation of MAPK pathway in CUMS mice model.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	34-37	glycogen synthase kinase 3 alpha	Mus musculus	88-97
34464700-24	2021	KEGG and Western blotting analysis suggested that BZD could exert antidepressant effects by regulating the PI3K/Akt and MAPK signaling pathways.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	50-53	thymoma viral proto-oncogene 1	Mus musculus	112-115
32959410-6	2020	RESULTS: Use of a non-IV BZD with high estimated effectiveness, like intranasal midazolam, rather than one with low estimated effectiveness, like rectal diazepam, would result in a median (p25 -p75 ) reduction in hospital admissions from 6 (3.9-8.8) to 1.1 (0.7-1.8) per 100 cases and associated cost reductions of $638 ($289-$1064) per pediatric patient and $1107 ($972-$1281) per adult patient.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	25-28	tubulin polymerization promoting protein	Homo sapiens	189-192
34022752-5	2021	The median (p25 to p75) time to first BZD on weekdays and weekends/holidays was 20 (6.8 to 48.3) minutes versus 11 (5 to 35) minutes, P = 0.01; adjusted hazard ratio (HR) = 1.20 (95% confidence interval [CI]: 0.95 to 1.55), P = 0.12.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	38-41	tubulin polymerization promoting protein	Homo sapiens	12-15
34022752-5	2021	The median (p25 to p75) time to first BZD on weekdays and weekends/holidays was 20 (6.8 to 48.3) minutes versus 11 (5 to 35) minutes, P = 0.01; adjusted hazard ratio (HR) = 1.20 (95% confidence interval [CI]: 0.95 to 1.55), P = 0.12.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	38-41	PC4 and SFRS1 interacting protein 1	Homo sapiens	19-22
34022752-7	2021	However, this difference was mainly driven by status epilepticus with in-hospital onset: among 108 patients, the time to first non-BZD ASM was longer during weekdays than during weekends/holidays (55.5 [28.8 to 103.5] minutes versus 28 [15.8 to 66.3] minutes, P = 0.003; adjusted HR = 1.65 [95% CI: 1.08 to 2.51], P = 0.01).	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	131-134	H19 imprinted maternally expressed transcript	Homo sapiens	135-138
34022752-8	2021	CONCLUSIONS: The time to first non-BZD ASM in pediatric refractory status epilepticus is shorter on weekends/holidays than on weekdays, mainly driven by in-hospital onset status epilepticus.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	35-38	H19 imprinted maternally expressed transcript	Homo sapiens	39-42
33912052-5	2021	NPA identified a key role for the NF-kappaB signaling pathway in the treatment of OA with BZD, which was confirmed by conventional western blot analysis.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	90-93	nuclear factor kappa B subunit 1	Homo sapiens	34-43
33912052-6	2021	This study identified and verified NF-kappaB signaling pathway as the most important inflammatory signaling pathway involved in the mechanisms of BZD for treating OA by comparing the NPA results with conventional methods.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	146-149	nuclear factor kappa B subunit 1	Homo sapiens	35-44
32959410-6	2020	RESULTS: Use of a non-IV BZD with high estimated effectiveness, like intranasal midazolam, rather than one with low estimated effectiveness, like rectal diazepam, would result in a median (p25 -p75 ) reduction in hospital admissions from 6 (3.9-8.8) to 1.1 (0.7-1.8) per 100 cases and associated cost reductions of $638 ($289-$1064) per pediatric patient and $1107 ($972-$1281) per adult patient.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	25-28	PC4 and SFRS1 interacting protein 1	Homo sapiens	194-197
27573669-4	2016	By combining in vivo sleep behavior, ex vivo electrophysiological recording from brain slices, and in silico molecular modeling, we demonstrate that (-)-alpha-pinene shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	247-250	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	225-230
27573669-4	2016	By combining in vivo sleep behavior, ex vivo electrophysiological recording from brain slices, and in silico molecular modeling, we demonstrate that (-)-alpha-pinene shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	302-305	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	225-230
22978105-8	2012	The contents of IL-1beta and NO were also lower in the BZD nutritive medium group with statistical difference when compared with those of the other two groups (P < 0.05).	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	55-58	interleukin 1 beta	Homo sapiens	16-24
26447772-7	2016	The acute effect of BZD on glucose uptake is mediated by increasing GLUT4 expression (around 140%) and its translocation to the plasma membrane in soleus muscle.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	20-23	solute carrier family 2 member 4	Homo sapiens	68-73
26497741-9	2015	The apoptotic rate and the loss of mitochondrial membrane potential (DeltaPsim) of the TM-stimulated chondrocytes treated with BZD was markedly decreased compared with those of chondrocytes not treated with BZD, as shown by 4",6-diamidino-2-phenylindole (DAPI) staining, Annexin V-FITC binding assay and JC-1 assay.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	127-130	annexin A5	Rattus norvegicus	271-280
25667638-7	2015	To gain insight into the mechanism underlying the effect of BZD on the cell cycle progression, the mRNA and protein expression of cyclin D1, cyclin-dependent kinase 4 (CDK4), CDK6 and p21 was measured by reverse transcription-polymerase chain reaction and western blotting, respectively.	N-BENZOYL-N'-BETA-D-GLUCOPYRANOSYL UREA	60-63	KRAS proto-oncogene, GTPase	Rattus norvegicus	184-187