PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1659892-1	1991	Specific binding sites for corticosteroid-binding globulin (CBG) and its pregnancy-associated variant (pCBG), having a modified carbohydrate moiety, were found in the plasma membranes of human liver, decidual endometrium and placental syncytiotrophoblast.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	103-107	serpin family A member 6	Homo sapiens	27-58
1659892-1	1991	Specific binding sites for corticosteroid-binding globulin (CBG) and its pregnancy-associated variant (pCBG), having a modified carbohydrate moiety, were found in the plasma membranes of human liver, decidual endometrium and placental syncytiotrophoblast.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	103-107	serpin family A member 6	Homo sapiens	60-63
35394106-8	2022	With the strong binding to retinoid X receptor-alpha (RXRA) and farnesoid X receptor (FXR) protein, pinocembrin-7-O-beta-D-glucoside (PCBG, the highest content in PCPE) and its metabolite PCB, could significantly increase the expression of RXRA, FXR and bile salt export pump (BSEP) in L02 cells, and significantly decrease the expression of cholesterol 7alpha-hydroxylase (CYP7A1) at mRNA and protein levels.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	134-138	procollagen C-endopeptidase enhancer	Homo sapiens	163-167
35394106-8	2022	With the strong binding to retinoid X receptor-alpha (RXRA) and farnesoid X receptor (FXR) protein, pinocembrin-7-O-beta-D-glucoside (PCBG, the highest content in PCPE) and its metabolite PCB, could significantly increase the expression of RXRA, FXR and bile salt export pump (BSEP) in L02 cells, and significantly decrease the expression of cholesterol 7alpha-hydroxylase (CYP7A1) at mRNA and protein levels.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	134-138	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	342-372
35394106-8	2022	With the strong binding to retinoid X receptor-alpha (RXRA) and farnesoid X receptor (FXR) protein, pinocembrin-7-O-beta-D-glucoside (PCBG, the highest content in PCPE) and its metabolite PCB, could significantly increase the expression of RXRA, FXR and bile salt export pump (BSEP) in L02 cells, and significantly decrease the expression of cholesterol 7alpha-hydroxylase (CYP7A1) at mRNA and protein levels.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	134-138	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	374-380
20837438-4	1988	In the isolated perfused rat kidney PCBG produced concentration-dependent nephrotoxicity as indicated by the occurrence in the urine of alkaline phosphatase and GGT and by the impairment of glucose reabsorption.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	36-40	gamma-glutamyltransferase 1	Rattus norvegicus	161-164
20837438-5	1988	The nephrotoxicity of PCBG was blocked by the specific GGT inhibitor, AT-125 (L-alphaS,5S)-alphaamino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid) and by aminooxyacetic aid (AOAA), an inhibitor of beta-lyase.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	22-26	gamma-glutamyltransferase 1	Rattus norvegicus	55-58
22343219-3	2012	In the present study, we demonstrate that cell-surface beta-glucan components of Pneumocystis (PCBG) stimulate human dendritic cells (DCs) to secrete IL-23 and IL-6.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	95-99	interleukin 23 subunit alpha	Homo sapiens	150-155
22343219-3	2012	In the present study, we demonstrate that cell-surface beta-glucan components of Pneumocystis (PCBG) stimulate human dendritic cells (DCs) to secrete IL-23 and IL-6.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	95-99	interleukin 6	Homo sapiens	160-164
22343219-5	2012	Accordingly, we further observe that PCBG-stimulated human DCs interact with lymphocytes to drive the secretion of IL-17 and IL-22, both Th17-produced cytokines.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	37-41	interleukin 17A	Homo sapiens	115-120
22343219-5	2012	Accordingly, we further observe that PCBG-stimulated human DCs interact with lymphocytes to drive the secretion of IL-17 and IL-22, both Th17-produced cytokines.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	37-41	interleukin 22	Homo sapiens	125-130
20626862-3	2010	Several previous studies indicate that airway epithelial cells release the neutrophil chemoattractant proteins, MIP-2 (rodents) and IL-8 (humans), in response to Pneumocystis and purified Pneumocystis cell wall beta-glucans (PCBG) through the NF-kappaB-dependent pathway.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	225-229	C-X-C motif chemokine ligand 2	Homo sapiens	112-117
20626862-3	2010	Several previous studies indicate that airway epithelial cells release the neutrophil chemoattractant proteins, MIP-2 (rodents) and IL-8 (humans), in response to Pneumocystis and purified Pneumocystis cell wall beta-glucans (PCBG) through the NF-kappaB-dependent pathway.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	225-229	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
20626862-4	2010	However, little is known about the molecular mechanisms that are involved in the activation of airway epithelium cells by PCBG resulting in the secretion of IL-8.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	122-126	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
20626862-6	2010	RESULTS: Our data provide evidence that PCBG induces phosphorylation of the MAPKs, ERK, and p38, the activation of NF-kappaB and the subsequently secretion of IL-8 in a calcium-dependent manner.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	40-44	mitogen-activated protein kinase 14	Homo sapiens	92-95
20626862-6	2010	RESULTS: Our data provide evidence that PCBG induces phosphorylation of the MAPKs, ERK, and p38, the activation of NF-kappaB and the subsequently secretion of IL-8 in a calcium-dependent manner.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
20626862-9	2010	CONCLUSION: These data indicate that PCBG activates calcium dependent MAPK signaling resulting in the release of IL-8 in a process that requires glycosphingolipid for optimal signaling.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	37-41	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
14550510-3	2003	Plasma porcine CBG (pCBG) concentration was correlated (r=0.34; P<0.05) with hepatic CBG mRNA level.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	20-24	corticosteroid-binding globulin	Sus scrofa	15-18
14550510-7	2003	An understanding of the relation between hepatic CBG mRNA and circulating pCBG concentrations may provide insight into the mechanisms determining the bioavailability of cortisol necessary in prenatal development and the conservation of cortisol during postnatal development in the pig.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	74-78	corticosteroid-binding globulin	Sus scrofa	49-52
7557430-5	1995	These P1-P5 sites are highly conserved in the human pCbg, and resemble recognition sequences for HNF-1, CP-2, DBP, HNF-3 and C/EBP or NF-1L6, respectively.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	52-56	HNF1 homeobox A	Homo sapiens	97-102
7557430-5	1995	These P1-P5 sites are highly conserved in the human pCbg, and resemble recognition sequences for HNF-1, CP-2, DBP, HNF-3 and C/EBP or NF-1L6, respectively.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	52-56	ceruloplasmin	Homo sapiens	104-108
7557430-5	1995	These P1-P5 sites are highly conserved in the human pCbg, and resemble recognition sequences for HNF-1, CP-2, DBP, HNF-3 and C/EBP or NF-1L6, respectively.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	52-56	D-box binding PAR bZIP transcription factor	Homo sapiens	110-113
7557430-5	1995	These P1-P5 sites are highly conserved in the human pCbg, and resemble recognition sequences for HNF-1, CP-2, DBP, HNF-3 and C/EBP or NF-1L6, respectively.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	52-56	forkhead box M1	Homo sapiens	115-120
7557430-5	1995	These P1-P5 sites are highly conserved in the human pCbg, and resemble recognition sequences for HNF-1, CP-2, DBP, HNF-3 and C/EBP or NF-1L6, respectively.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	52-56	CCAAT enhancer binding protein alpha	Homo sapiens	125-130
7557430-5	1995	These P1-P5 sites are highly conserved in the human pCbg, and resemble recognition sequences for HNF-1, CP-2, DBP, HNF-3 and C/EBP or NF-1L6, respectively.	S-(1,2,3,4,4-Pentachloro-1,3-butadienyl)glutathione	52-56	neurofibromin 1 pseudogene 6	Homo sapiens	134-140