PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12198162-0 2002 Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 30-33 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 55-60 12198162-2 2002 The 2.2 A crystal structure of the N-terminal domain of Orc1p revealed a BAH core and a non-conserved helical sub-domain. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 73-76 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 56-61 35419730-2 2022 We studied the neuroprotective effects of betulinic hydroxamate (BAH), a novel B55alpha/PP2A activator that dephosphorylates and inhibits PHD2 activity, in a rat model of neonatal HIBD. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 65-68 egl-9 family hypoxia-inducible factor 1 Rattus norvegicus 138-142 33811077-5 2021 These data reveal PBRM1 functions beyond chromatin remodeling with domains that allow it to integrate chromatin and cytoskeletal activity via its acetyl-binding BD and methyl-binding BAH domains, respectively. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 183-186 polybromo 1 Homo sapiens 18-23 34339019-4 2021 Firstly, we showed the molecular mechanisms through which BAH modifies the activity of the PHD2 prolyl hydroxylase, thus directly affecting HIF-1alpha stability. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 58-61 egl-9 family hypoxia-inducible factor 1 Mus musculus 91-95 34339019-4 2021 Firstly, we showed the molecular mechanisms through which BAH modifies the activity of the PHD2 prolyl hydroxylase, thus directly affecting HIF-1alpha stability. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 58-61 hypoxia inducible factor 1, alpha subunit Mus musculus 140-150 34339019-5 2021 BAH treatment reduces PHD2 phosphorylation on Ser-125 residue, responsible for the control of its hydrolase activity. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 egl-9 family hypoxia-inducible factor 1 Mus musculus 22-26 34339019-6 2021 HIF activation by BAH is inhibited by okadaic acid and LB-100 indicating that a protein phosphatase 2A (PP2A) is implicated in the mechanism of action of BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 18-21 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 88-102 34339019-6 2021 HIF activation by BAH is inhibited by okadaic acid and LB-100 indicating that a protein phosphatase 2A (PP2A) is implicated in the mechanism of action of BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 18-21 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 104-108 34339019-6 2021 HIF activation by BAH is inhibited by okadaic acid and LB-100 indicating that a protein phosphatase 2A (PP2A) is implicated in the mechanism of action of BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 154-157 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 88-102 34339019-6 2021 HIF activation by BAH is inhibited by okadaic acid and LB-100 indicating that a protein phosphatase 2A (PP2A) is implicated in the mechanism of action of BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 154-157 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 104-108 34339019-7 2021 Furthermore, in striatal cells bearing a mutated form of the huntingtin protein, BAH stabilized HIF-1alpha protein, induced Vegf and Bnip3 gene expression and protected against mitochondrial toxin-induced cytotoxicity. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 81-84 huntingtin Mus musculus 61-71 34339019-7 2021 Furthermore, in striatal cells bearing a mutated form of the huntingtin protein, BAH stabilized HIF-1alpha protein, induced Vegf and Bnip3 gene expression and protected against mitochondrial toxin-induced cytotoxicity. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 81-84 hypoxia inducible factor 1, alpha subunit Mus musculus 96-106 34339019-7 2021 Furthermore, in striatal cells bearing a mutated form of the huntingtin protein, BAH stabilized HIF-1alpha protein, induced Vegf and Bnip3 gene expression and protected against mitochondrial toxin-induced cytotoxicity. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 81-84 vascular endothelial growth factor A Mus musculus 124-128 34339019-7 2021 Furthermore, in striatal cells bearing a mutated form of the huntingtin protein, BAH stabilized HIF-1alpha protein, induced Vegf and Bnip3 gene expression and protected against mitochondrial toxin-induced cytotoxicity. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 81-84 BCL2/adenovirus E1B interacting protein 3 Mus musculus 133-138 34339019-10 2021 Taken together, our results show BAH"s ability to activate the PP2A/PHD2/HIF pathway, which may have important implications in the treatment of HD and perhaps other neurodegenerative diseases. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 33-36 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 63-67 34339019-10 2021 Taken together, our results show BAH"s ability to activate the PP2A/PHD2/HIF pathway, which may have important implications in the treatment of HD and perhaps other neurodegenerative diseases. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 33-36 egl-9 family hypoxia-inducible factor 1 Mus musculus 68-72 8582103-7 1995 During ACTH infusion, aldosterone levels in AII-U and AII-R APA were similar, and higher than those in BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 103-106 proopiomelanocortin Homo sapiens 7-11 33823544-0 2021 A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 12-15 bromo adjacent homology domain containing 1 Homo sapiens 40-45 35419730-8 2022 BAH showed a robust protective effect on myelination, restoring MBP expression at P37. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 myelin basic protein Rattus norvegicus 64-67 33277495-6 2020 We found that the BAH-PHD module associates with CPL2, a plant-specific Pol II carboxyl terminal domain (CTD) phosphatase, to form the BAH-PHD-CPL2 complex (BPC) for transcriptional repression. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 18-21 carboxyl-terminal domain (ctd) phosphatase-like 2 Arabidopsis thaliana 143-147 33630995-12 2021 CONCLUSIONS: We present a pediatric patient with CS due to BAH and a germline defect in KCNJ5. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 59-62 citrate synthase Homo sapiens 49-51 33630995-14 2021 However, this KCNJ5 variant differed in its function from KCNJ5 defects leading to PA. We speculate that GIRK4 (Kir3.4) may play a role in early human adrenocortical development and zonation and participate in the pathogenesis of pediatric BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 240-243 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 14-19 33630995-14 2021 However, this KCNJ5 variant differed in its function from KCNJ5 defects leading to PA. We speculate that GIRK4 (Kir3.4) may play a role in early human adrenocortical development and zonation and participate in the pathogenesis of pediatric BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 240-243 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 105-110 33630995-14 2021 However, this KCNJ5 variant differed in its function from KCNJ5 defects leading to PA. We speculate that GIRK4 (Kir3.4) may play a role in early human adrenocortical development and zonation and participate in the pathogenesis of pediatric BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 240-243 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 112-118 33112806-6 2021 The PDE2A heterozygous variant (p.Ile629Val) was identified in a patient with BAH and early-onset HT at 13 yrs of age. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 78-81 phosphodiesterase 2A Homo sapiens 4-9 33112806-7 2021 Two PDE3B heterozygous variants (p.Arg217Gln and p.Gly392Val) were identified in patients with BAH and HT diagnosed at 18 and 33 yrs of age, respectively. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 95-98 phosphodiesterase 3B Homo sapiens 4-9 33112806-8 2021 A strong PDE2A staining was found in all cases of BAH in zona glomerulosa and/or micronodules (that were also positive for CYP11B2). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 50-53 phosphodiesterase 2A Homo sapiens 9-14 33112806-8 2021 A strong PDE2A staining was found in all cases of BAH in zona glomerulosa and/or micronodules (that were also positive for CYP11B2). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 50-53 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 123-130 33112806-9 2021 PKA activity in frozen tissue was significantly higher in BAH from patients harboring PDE2A and PDE3B variants. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 58-61 phosphodiesterase 2A Homo sapiens 86-91 33112806-9 2021 PKA activity in frozen tissue was significantly higher in BAH from patients harboring PDE2A and PDE3B variants. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 58-61 phosphodiesterase 3B Homo sapiens 96-101 33112806-12 2021 In conclusion, PDE2A and PDE3B variants were associated with PA caused by BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 74-77 phosphodiesterase 2A Homo sapiens 15-20 33112806-12 2021 In conclusion, PDE2A and PDE3B variants were associated with PA caused by BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 74-77 phosphodiesterase 3B Homo sapiens 25-30 32895490-5 2021 RESULTS: Three PRKAR1B germline variants (p.I40V, p.A67V, p.A300T) were identified among 74 patients with BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 106-109 protein kinase cAMP-dependent type I regulatory subunit beta Homo sapiens 15-22 32825929-6 2020 Mean H-scores for EZH2 progressively increased from BAH (23.5), to AAH (47.4) and ADCIS (196.4), and showed a significant difference utilizing the Kruskal-Wallis test (p < 0.0001). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 52-55 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens 18-22 33277495-5 2020 The BAH-PHD bivalent histone reader complex silences a substantial subset of H3K27me3-enriched loci, including a number of development and stress response-related genes such as the RNA silencing effector gene ARGONAUTE 5 (AGO5). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 4-7 Argonaute family protein Arabidopsis thaliana 209-220 33277495-5 2020 The BAH-PHD bivalent histone reader complex silences a substantial subset of H3K27me3-enriched loci, including a number of development and stress response-related genes such as the RNA silencing effector gene ARGONAUTE 5 (AGO5). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 4-7 Argonaute family protein Arabidopsis thaliana 222-226 33277495-6 2020 We found that the BAH-PHD module associates with CPL2, a plant-specific Pol II carboxyl terminal domain (CTD) phosphatase, to form the BAH-PHD-CPL2 complex (BPC) for transcriptional repression. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 18-21 carboxyl-terminal domain (ctd) phosphatase-like 2 Arabidopsis thaliana 49-53 25971952-2 2015 These findings have followed the discovery that defects of primary genes of the cyclic monophosphatase (cAMP) signaling pathway, such as guanine nucleotide binding alpha subunit and PRKAR1A, are involved in the pathogenesis of BAH in humans; complete absence of Prkar1a in the adrenal cortex of mice also led to pathology that mimicked the human disease. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 227-230 protein kinase cAMP-dependent type I regulatory subunit alpha Homo sapiens 182-189 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 tenascin C Mus musculus 72-75 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 collagen, type I, alpha 2 Mus musculus 77-83 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 collagen, type III, alpha 1 Mus musculus 85-91 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 tissue inhibitor of metalloproteinase 1 Mus musculus 93-99 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 actin alpha 2, smooth muscle, aorta Mus musculus 101-110 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 CD247 antigen Mus musculus 146-149 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 interleukin 1 alpha Mus musculus 152-160 32811965-7 2021 BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, alpha-SMA) and inflammatory markers (F4/80+, CD3+, Il-1beta, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 chemokine (C-C motif) ligand 3 Mus musculus 162-166 31637427-7 2020 CONCLUSIONS: Thus, this patient represents a unique case of BAH due to a mosaic KCNJ5 defect. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 60-63 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 80-85 30082786-4 2018 Furthermore, in the monocot rice a homolog of the Arabidopsis BAH-domain proteins also binds methylated H3K27 and forms a complex with the rice homolog of EMF1, suggesting that BAH-EMF1c is conserved in flowering plants. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 62-65 embryonic flower 1 (EMF1) Arabidopsis thaliana 155-159 26876097-4 2016 The crystal structure of ORC1b BAH-PHD cassette in complex with an H3(1-15) peptide reveals a strict requirement for the unmodified state of R2, T3, and K4 on the H3 tail and a novel multivalent BAH and PHD readout mode for H3 peptide recognition. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 31-34 origin of replication complex 1B Arabidopsis thaliana 25-30 26876097-4 2016 The crystal structure of ORC1b BAH-PHD cassette in complex with an H3(1-15) peptide reveals a strict requirement for the unmodified state of R2, T3, and K4 on the H3 tail and a novel multivalent BAH and PHD readout mode for H3 peptide recognition. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 195-198 origin of replication complex 1B Arabidopsis thaliana 25-30 31651844-2 2019 An accurate discrimination between APA and BAH is crucial because the former is treated with adrenalectomy (ADX) and the latter is primarily by aldosterone antagonists. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 43-46 ferredoxin 1 Homo sapiens 108-111 30341171-0 2018 BAH domains and a histone-like motif in DNA methyltransferase 1 (DNMT1) regulate de novo and maintenance methylation in vivo. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 0-3 DNA methyltransferase (cytosine-5) 1 Mus musculus 65-70 30341171-4 2018 We removed the BAH domains by means of a CRISPR/Cas9-mediated deletion within the endogenous Dnmt1 locus. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 15-18 DNA methyltransferase (cytosine-5) 1 Mus musculus 93-98 25971952-2 2015 These findings have followed the discovery that defects of primary genes of the cyclic monophosphatase (cAMP) signaling pathway, such as guanine nucleotide binding alpha subunit and PRKAR1A, are involved in the pathogenesis of BAH in humans; complete absence of Prkar1a in the adrenal cortex of mice also led to pathology that mimicked the human disease. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 227-230 protein kinase cAMP-dependent type I regulatory subunit alpha Homo sapiens 262-269 25971952-3 2015 Here, we review the most recent findings in human and mouse studies on PDE8B, a cAMP-specific PDE that appears to be highly expressed in the adrenal cortex and whose deficiency may underlie predisposition to BAH and possibly other human diseases. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 208-211 phosphodiesterase 8B Mus musculus 71-76 26042218-5 2015 PRKACA copy number gain was found in the germline of several patients with cortisol-producing BAH, whereas the somatic Leu206Arg (c.617A>C) recurrent PRKACA mutation was found in as many as half of all adrenocortical adenomas associated with AICS. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 94-97 protein kinase cAMP-activated catalytic subunit alpha Homo sapiens 0-6 24503858-5 2014 The proteomic analysis showed a different expression of Serpin B3 Inhibitor-SCCA1 (SB3) in APA and BAH patients. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 99-102 serpin family B member 3 Homo sapiens 56-65 23934150-2 2013 The crystal structure of the N-terminally acetylated BAH domain of Saccharomyces cerevisiae Sir3 bound to the nucleosome core particle reveals that the N-terminal acetylation stabilizes the interaction of Sir3 with the nucleosome. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 53-56 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 92-96 23934152-0 2013 Nalpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 87-90 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 18-22 23934150-2 2013 The crystal structure of the N-terminally acetylated BAH domain of Saccharomyces cerevisiae Sir3 bound to the nucleosome core particle reveals that the N-terminal acetylation stabilizes the interaction of Sir3 with the nucleosome. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 53-56 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 205-209 20974972-6 2010 These findings demonstrate that Orc1 functioned in silencing before duplication and suggest that Orc1 and Sir2, both of which are broadly conserved among eukaryotes, may have an ancient history of cooperating to generate chromatin structures, with Sir2 deacetylating histones and Orc1 binding to these deacetylated nucleosomes through its BAH domain. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 339-342 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 32-36 22405012-4 2012 Cdc6 binding changes the conformation of ORC, in particular reorienting the Orc1 N-terminal BAH domain. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 92-95 AAA family ATPase CDC6 Saccharomyces cerevisiae S288C 0-4 22405012-4 2012 Cdc6 binding changes the conformation of ORC, in particular reorienting the Orc1 N-terminal BAH domain. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 92-95 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 76-80 22398447-4 2012 Recognition of H4K20me2 is a property common to BAH domains present within diverse metazoan ORC1 proteins. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 48-51 origin recognition complex subunit 1 Homo sapiens 92-96 22398447-10 2012 Together, our results identify the BAH domain as a novel methyl-lysine-binding module, thereby establishing the first direct link between histone methylation and the metazoan DNA replication machinery, and defining a pivotal aetiological role for the canonical H4K20me2 mark, via ORC1, in primordial dwarfism. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 35-38 origin recognition complex subunit 1 Homo sapiens 280-284 20974972-6 2010 These findings demonstrate that Orc1 functioned in silencing before duplication and suggest that Orc1 and Sir2, both of which are broadly conserved among eukaryotes, may have an ancient history of cooperating to generate chromatin structures, with Sir2 deacetylating histones and Orc1 binding to these deacetylated nucleosomes through its BAH domain. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 339-342 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 97-101 20974972-6 2010 These findings demonstrate that Orc1 functioned in silencing before duplication and suggest that Orc1 and Sir2, both of which are broadly conserved among eukaryotes, may have an ancient history of cooperating to generate chromatin structures, with Sir2 deacetylating histones and Orc1 binding to these deacetylated nucleosomes through its BAH domain. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 339-342 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 97-101 18203722-10 2008 Aldosterone-renin ratio (ARR) after administration of 50 mg captopril was higher in bilateral APA than in BAH patients (p = 0.023), but not different between unilateral APA and BAH (p = 0.218). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 106-109 renin Homo sapiens 12-17 19171939-10 2009 We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 251-254 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 49-53 19171939-10 2009 We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 251-254 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 75-79 19171939-10 2009 We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 251-254 Sir1p Saccharomyces cerevisiae S288C 171-175 19171939-10 2009 We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 251-254 Sir1p Saccharomyces cerevisiae S288C 202-206 19171939-10 2009 We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 251-254 Sir1p Saccharomyces cerevisiae S288C 202-206 19171939-10 2009 We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 251-254 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 221-225 18491255-2 2008 We recently identified patients with a micronodular form of BAH that we have called "isolated micronodular adrenocortical disease" (iMAD) in whom CS was associated with inactivating mutations in phosphodiesterase (PDE) 11A ( PDE11A). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 60-63 phosphodiesterase 11A Homo sapiens 214-222 18491255-2 2008 We recently identified patients with a micronodular form of BAH that we have called "isolated micronodular adrenocortical disease" (iMAD) in whom CS was associated with inactivating mutations in phosphodiesterase (PDE) 11A ( PDE11A). bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 60-63 phosphodiesterase 11A Homo sapiens 225-231 18794362-5 2008 The BAH point mutants, but not the L738P mutant, disrupted the interaction between Sir3 and nucleosomes. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 4-7 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 83-87 18391024-9 2008 Our results suggest that the BAH domain of Sir3 binds to histone H3K79 and that acetylation of the BAH domain is required for the binding specificity of Sir3 for nucleosomes unmethylated at H3K79. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 29-32 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 43-47 18391024-9 2008 Our results suggest that the BAH domain of Sir3 binds to histone H3K79 and that acetylation of the BAH domain is required for the binding specificity of Sir3 for nucleosomes unmethylated at H3K79. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 99-102 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 153-157 15932939-2 2005 Here, we present the high-resolution crystal structures of the ORC interaction region (OIR) of Sir1p and that of the complex formed between the OIR and BAH domains. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 152-155 Sir1p Saccharomyces cerevisiae S288C 95-100 17066079-6 2006 Moreover, the BAH domain affected Orc1"s ability to promote binding of Orc2 to chromatin as cells exit mitosis. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 14-17 origin recognition complex subunit 1 Homo sapiens 34-38 17066079-6 2006 Moreover, the BAH domain affected Orc1"s ability to promote binding of Orc2 to chromatin as cells exit mitosis. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 14-17 origin recognition complex subunit 2 Homo sapiens 71-75 16581798-10 2006 This superhelix may be relevant to the function of the BAH domain of Sir3 in silencing. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 55-58 chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C 69-73