PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25104312-5	2014	Exposure to 10 microM Be(2+) produced a decrease in GSK-3beta kinase activity that was comparable to that produced by 10 mM Li(+), indicating that beryllium is about 1,000-fold more potent than the classical inhibitor when treating intact cells.	beryllium(2+)	22-28	glycogen synthase kinase 3 beta	Homo sapiens	52-61
34404214-8	2021	Ultimately, our simulations show that Li+ inhibition is driven by decreasing the phosphorylation reaction rate, rather than reducing catalytic turnover through tight binding to different GSK-3beta states like Be2+ inhibition.	beryllium(2+)	209-213	glycogen synthase kinase 3 alpha	Homo sapiens	187-196
6170354-1	1981	Rats given an LD50 dose of Be2+ showed reduced activities of ornithine decarboxylase and tyrosine aminotransferase in liver in response to dexamethasone induction.	beryllium(2+)	27-31	ornithine decarboxylase 1	Rattus norvegicus	61-84
2521626-1	1989	Complexes formed from A13+ or Be2+ and fluoride inhibit the single-stranded DNA-dependent ATPase activity of RecA protein.	beryllium(2+)	30-34	RAD51 recombinase	Homo sapiens	109-113
28721440-4	2018	The aim of this work was to investigate both in vitro and in cultured cells if other divalent cations (Sr2+, Ba2+, Co2+, Cd2+, Pb2+ or Be2+) could be transported by PMCA.	beryllium(2+)	135-139	ATPase plasma membrane Ca2+ transporting 1	Canis lupus familiaris	165-169
14756259-1	2003	The complexation equilibria between Be2+ and the hydrogen salicylate (HL-) ions have been studied, at 25 degrees C, by potentiometric measurements with a glass electrode in 3 M NaClO4.	beryllium(2+)	36-40	hes family bHLH transcription factor 1	Rattus norvegicus	70-72
17963236-5	2008	At low concentrations, Be2+ increased the catalytic efficiency of the polymerase, while at higher concentrations, it competed with Mg2+ for binding to site A, and inhibited DNA polymerization.	beryllium(2+)	23-27	mucin 7, secreted	Homo sapiens	131-134
2009323-5	1991	The prevention by Be2+ of the down-regulation of c-myc expression in serum-stimulated BL9L cells appears to result from a modulation of the endogenous transcriptional control process for c-myc, which allows a maintained expression of the gene.	beryllium(2+)	18-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-54
2009323-5	1991	The prevention by Be2+ of the down-regulation of c-myc expression in serum-stimulated BL9L cells appears to result from a modulation of the endogenous transcriptional control process for c-myc, which allows a maintained expression of the gene.	beryllium(2+)	18-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	187-192
2405251-4	1990	HOL1 double mutants and, to a lesser extent, HOL1-1 single mutants show hypersensitivity to specific cations added to the growth medium, including Na+, Li+, Cs+, Be2+, guanidinium ion, and histidinol, but not K+, Rb+, Ca2+, or Mg2+.	beryllium(2+)	162-166	Hol1p	Saccharomyces cerevisiae S288C	0-4
2405251-4	1990	HOL1 double mutants and, to a lesser extent, HOL1-1 single mutants show hypersensitivity to specific cations added to the growth medium, including Na+, Li+, Cs+, Be2+, guanidinium ion, and histidinol, but not K+, Rb+, Ca2+, or Mg2+.	beryllium(2+)	162-166	Hol1p	Saccharomyces cerevisiae S288C	45-51