PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2752025-3 1989 Mg2+ forms crystalline complexes with saturated phosphatidylserines, such as DMPS, and probably with POPS. Unithiol 77-81 mucin 7, secreted Homo sapiens 0-3 2752025-6 1989 One main conclusion of this work is that Mg2+ binding to PS bilayers shows a gradation, the binding is in the order DMPS greater than POPS greater than ox brain PS greater than DOPS. Unithiol 116-120 mucin 7, secreted Homo sapiens 41-44 2898331-6 1988 Reduction of DMPS disulfide to DMPS also occurred in EDTA-Tris HCl (pH 9) containing glutathione disulfide and glutathione reductase. Unithiol 13-17 glutathione-disulfide reductase Gallus gallus 111-132 33113271-7 2020 GO analysis revealed that DMPs were significantly enriched in 540 GO terms, which included regulation of the differentiation of keratinocytes, T-helper cell differentiation, and alpha-beta T cell differentiation. Unithiol 26-30 amyloid beta precursor protein Homo sapiens 178-188 33279932-9 2021 The genes associated with top-ranked DMPs also included many genes involved in nervous system development, such as LIMK2 and TMOD2. Unithiol 37-41 LIM domain kinase 2 Homo sapiens 115-120 33279932-9 2021 The genes associated with top-ranked DMPs also included many genes involved in nervous system development, such as LIMK2 and TMOD2. Unithiol 37-41 tropomodulin 2 Homo sapiens 125-130 33113271-8 2020 Moreover, significant enrichment of KEGG pathways of the DMPs included mucin type O-glycan biosynthesis, focal adhesion, and the insulin signaling pathway. Unithiol 57-61 LOC100508689 Homo sapiens 71-76 32233750-5 2020 Correlation between DNA methylation levels in DMPs and phospho-tau protein burden assessed by immunohistochemistry in the hippocampus was also determined.We found 4 DMPs showing higher levels of DNA methylation at early AD stages compared to controls, involving ELOVL2, GIT1/TP53I13 and the histone gene locus at chromosome 6. Unithiol 165-169 ELOVL fatty acid elongase 2 Homo sapiens 262-268 32233750-5 2020 Correlation between DNA methylation levels in DMPs and phospho-tau protein burden assessed by immunohistochemistry in the hippocampus was also determined.We found 4 DMPs showing higher levels of DNA methylation at early AD stages compared to controls, involving ELOVL2, GIT1/TP53I13 and the histone gene locus at chromosome 6. Unithiol 165-169 GIT ArfGAP 1 Homo sapiens 270-274 32233750-5 2020 Correlation between DNA methylation levels in DMPs and phospho-tau protein burden assessed by immunohistochemistry in the hippocampus was also determined.We found 4 DMPs showing higher levels of DNA methylation at early AD stages compared to controls, involving ELOVL2, GIT1/TP53I13 and the histone gene locus at chromosome 6. Unithiol 165-169 tumor protein p53 inducible protein 13 Homo sapiens 275-282 32470185-11 2020 When DMRs and DMPs were annotated to genes, 3 genes associated with imprinting were found: IGF2, PRDM16, and CLF4/BRUNOL4. Unithiol 14-18 insulin like growth factor 2 Homo sapiens 91-95 32470185-11 2020 When DMRs and DMPs were annotated to genes, 3 genes associated with imprinting were found: IGF2, PRDM16, and CLF4/BRUNOL4. Unithiol 14-18 PR/SET domain 16 Homo sapiens 97-103 32470185-11 2020 When DMRs and DMPs were annotated to genes, 3 genes associated with imprinting were found: IGF2, PRDM16, and CLF4/BRUNOL4. Unithiol 14-18 CUGBP Elav-like family member 4 Homo sapiens 114-121 31279243-8 2019 We further detected group-specific between-brain-region gene expression differences in ODC1, CALY, GALNT2, and GABRD, which contained significant between-brain-region DMPs. Unithiol 167-171 ornithine decarboxylase 1 Homo sapiens 87-91 32736574-11 2020 For DMPs located in promoter CpG islands showing extreme hypermethylation, the candidate gene with the largest number of DMPs (n = 7) was mapped to HOXA5. Unithiol 4-8 homeobox A5 Homo sapiens 148-153 32736574-11 2020 For DMPs located in promoter CpG islands showing extreme hypermethylation, the candidate gene with the largest number of DMPs (n = 7) was mapped to HOXA5. Unithiol 121-125 homeobox A5 Homo sapiens 148-153 32117312-4 2020 Results: Analyses of these data revealed significantly more differentially methylated positions (DMPs) in CD4+ memory than in CD4+ naive T cells (904 vs. 19 DMPs) in RA patients compared to controls. Unithiol 97-101 CD4 molecule Homo sapiens 106-109 31279243-8 2019 We further detected group-specific between-brain-region gene expression differences in ODC1, CALY, GALNT2, and GABRD, which contained significant between-brain-region DMPs. Unithiol 167-171 calcyon neuron specific vesicular protein Homo sapiens 93-97 31279243-8 2019 We further detected group-specific between-brain-region gene expression differences in ODC1, CALY, GALNT2, and GABRD, which contained significant between-brain-region DMPs. Unithiol 167-171 polypeptide N-acetylgalactosaminyltransferase 2 Homo sapiens 99-105 31279243-8 2019 We further detected group-specific between-brain-region gene expression differences in ODC1, CALY, GALNT2, and GABRD, which contained significant between-brain-region DMPs. Unithiol 167-171 gamma-aminobutyric acid type A receptor subunit delta Homo sapiens 111-116 28635014-5 2017 WHAT IS NEW AND CONCLUSION: Clinicians should keep in mind haemolysis as a potentially life-threatening side effect of DMPS in patients with G6PD. Unithiol 119-123 glucose-6-phosphate dehydrogenase Homo sapiens 141-145 30639570-6 2019 Ingenuity pathway analysis of 39 genes with DMPs for both CPSP and CASI revealed enrichment of several canonical pathways, including GABA receptor (P = .00016 for CPSP; P =.0008 for CASI) and dopamine-DARPP32 feedback in cyclic adenosine monophosphate (P = .004 for CPSP and P =.00003 for CASI) signaling. Unithiol 44-48 GABA type A receptor-associated protein Homo sapiens 133-146 30639570-6 2019 Ingenuity pathway analysis of 39 genes with DMPs for both CPSP and CASI revealed enrichment of several canonical pathways, including GABA receptor (P = .00016 for CPSP; P =.0008 for CASI) and dopamine-DARPP32 feedback in cyclic adenosine monophosphate (P = .004 for CPSP and P =.00003 for CASI) signaling. Unithiol 44-48 protein phosphatase 1 regulatory inhibitor subunit 1B Homo sapiens 201-208 31036381-12 2019 Furthermore, DMPs sensitized TRPV1 responses in mouse trigeminal neurons with greater activity seen with extracts from root dentin. Unithiol 13-17 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 29-34 29556023-3 2018 Using Illumina 450k arrays for 194 patients from The Cancer Genome Atlas, we identified two distinct DMPs by hierarchical clustering: DMP.1 and DMP.2. Unithiol 101-105 dentin matrix acidic phosphoprotein 1 Homo sapiens 134-139 24530897-3 2014 P45 peptide showed lower surface activity and less extent of penetration into 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (DMPS) (3:2, mol/mol) lipid monolayers than P58 and P59. Unithiol 180-184 nuclear factor, erythroid 2 Homo sapiens 0-3 26889208-11 2016 We also show that ERbeta is recruited to regions around hypermethylated DMPs. Unithiol 72-76 estrogen receptor 2 (beta) Mus musculus 18-24 26889208-12 2016 Finally, we demonstrate here that ERbeta interacts with TDG and that TDG binds ERbeta-dependently to hypermethylated DMPs. Unithiol 117-121 thymine DNA glycosylase Mus musculus 69-72 26889208-12 2016 Finally, we demonstrate here that ERbeta interacts with TDG and that TDG binds ERbeta-dependently to hypermethylated DMPs. Unithiol 117-121 estrogen receptor 2 (beta) Mus musculus 79-85 25918994-8 2015 Remarkably, one of these DMPs (cg01122889) was located in the WDR26 gene, the DNA sequence of which has been implicated in major depressive disorder from genome-wide association studies. Unithiol 25-29 WD repeat domain 26 Homo sapiens 62-67 24929637-9 2014 RESULTS: Two reproducible depression-associated DMPs were identified, including the top-ranked DMP that was located within STK32C, which encodes a serine/threonine kinase, of unknown function. Unithiol 48-52 serine/threonine kinase 32C Homo sapiens 123-129 19806735-5 2009 The additional assessment of the stability of Hg2+-PCn complexes was achieved through ITC by using the therapeutic chelator sodium 2,3-dimercaptopropanesulfate (DMPS) over Hg2+-PCn systems. Unithiol 161-165 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 46-49 24562313-4 2014 In vitro, DMPs enhanced alkaline phosphatase activity and mineralization in BMMSCs cultures as well as increasing the expression of dentinogenic and osteogenic differentiation markers (including runt-related transcription factor 2, osterix, bone sialoprotein, dentin sialophosphoprotein and osteocalcin) at both transcript and protein levels, with 10 mug/mL DMPs being the optimal stimulatory concentration. Unithiol 10-14 Sp7 transcription factor Homo sapiens 232-239 24562313-5 2014 Expression of phosphor-ERK/phosphor-P38 in BMMSCs was up-regulated by DMPs and, in the presence of the ERK1/2- and p38-specific inhibitors, the differentiation of BMMSCs was inhibited. Unithiol 70-74 mitogen-activated protein kinase 1 Homo sapiens 23-26 24562313-5 2014 Expression of phosphor-ERK/phosphor-P38 in BMMSCs was up-regulated by DMPs and, in the presence of the ERK1/2- and p38-specific inhibitors, the differentiation of BMMSCs was inhibited. Unithiol 70-74 mitogen-activated protein kinase 1 Homo sapiens 36-39 24562313-5 2014 Expression of phosphor-ERK/phosphor-P38 in BMMSCs was up-regulated by DMPs and, in the presence of the ERK1/2- and p38-specific inhibitors, the differentiation of BMMSCs was inhibited. Unithiol 70-74 mitogen-activated protein kinase 3 Homo sapiens 103-109 24562313-5 2014 Expression of phosphor-ERK/phosphor-P38 in BMMSCs was up-regulated by DMPs and, in the presence of the ERK1/2- and p38-specific inhibitors, the differentiation of BMMSCs was inhibited. Unithiol 70-74 mitogen-activated protein kinase 1 Homo sapiens 115-118 24562313-6 2014 These data indicate that DMPs promote the dentinogenic/osteogenic differentiation of BMMSCs via the ERK/p38 MAPK pathways. Unithiol 25-29 mitogen-activated protein kinase 1 Homo sapiens 100-103 24562313-6 2014 These data indicate that DMPs promote the dentinogenic/osteogenic differentiation of BMMSCs via the ERK/p38 MAPK pathways. Unithiol 25-29 mitogen-activated protein kinase 1 Homo sapiens 104-107 24562313-6 2014 These data indicate that DMPs promote the dentinogenic/osteogenic differentiation of BMMSCs via the ERK/p38 MAPK pathways. Unithiol 25-29 mitogen-activated protein kinase 3 Homo sapiens 108-112 19063911-0 2009 MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA. Unithiol 84-88 ATP binding cassette subfamily C member 2 Rattus norvegicus 0-4 19063911-3 2009 In the present study, we extended our previous studies by testing the hypothesis that MRP2 mediates the secretion of DMPS or DMSA S-conjugates of CH(3)Hg(+). Unithiol 117-121 ATP binding cassette subfamily C member 2 Rattus norvegicus 86-90 19063911-11 2009 Our findings in inside-out membrane vesicles prepared from hMRP2-transfected Sf9 cells show that uptake of DMPS and DMSA S-conjugates of CH(3)Hg(+) was greater in the vesicles containing hMRP2 than in control vesicles. Unithiol 107-111 ATP binding cassette subfamily C member 2 Homo sapiens 59-64 19063911-11 2009 Our findings in inside-out membrane vesicles prepared from hMRP2-transfected Sf9 cells show that uptake of DMPS and DMSA S-conjugates of CH(3)Hg(+) was greater in the vesicles containing hMRP2 than in control vesicles. Unithiol 107-111 ATP binding cassette subfamily C member 2 Homo sapiens 187-192 19063911-12 2009 Overall, these dispositional findings indicate that MRP2 does play a role in DMPS- and DMSA-mediated elimination of mercury from the kidney. Unithiol 77-81 ATP binding cassette subfamily C member 2 Rattus norvegicus 52-56 17100619-6 2006 Another bioactive moiety of PGNs, diaminopimelic acid (DAP) containing desmuramylpeptides (DMPs), senses another intracellular receptor, NOD1. Unithiol 91-95 nucleotide-binding oligomerization domain containing 1 Mus musculus 137-141 16850446-2 2006 An earlier study showed that DMPS increased the transport of insulin across porcine epidermis under electroporation by approximately fourfold. Unithiol 29-33 insulin Homo sapiens 61-68 16850446-4 2006 When electroosmosis was applied across the epidermis following electroporation with DMPS, the enhancement of insulin transport was approximately 18-fold over electroporation alone. Unithiol 84-88 insulin Homo sapiens 109-116 17100619-9 2006 In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion. Unithiol 39-43 C-X-C motif chemokine ligand 8 Homo sapiens 94-112 17100619-9 2006 In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion. Unithiol 39-43 nucleotide binding oligomerization domain containing 1 Homo sapiens 238-242 17100619-9 2006 In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion. Unithiol 39-43 nucleotide binding oligomerization domain containing 2 Homo sapiens 247-251 17100619-9 2006 In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion. Unithiol 39-43 C-X-C motif chemokine ligand 8 Homo sapiens 322-326 17100619-9 2006 In human monocytic cells, both MDP and DMPs exhibited definite activities; marked synergistic interleukin (IL)-8 secretion was induced by DMPs and MDP in combination with synthetic TLR agonists, and suppression of the mRNA expressions of NOD1 and NOD2, respectively, by RNA interference specifically inhibited synergistic IL-8 secretion. Unithiol 138-142 C-X-C motif chemokine ligand 8 Homo sapiens 94-112 12237339-10 2002 These results indicate that the MeHg antidotes NAC and DMPS and their mercaptide complexes are transported by Oat1 but are comparatively poor substrates for Oat3. Unithiol 55-59 solute carrier family 22 member 6 Rattus norvegicus 110-114 13129851-0 2004 Interaction of the metal chelator DMPS with OAT1 and OAT3 in intact isolated rabbit renal proximal tubules. Unithiol 34-38 solute carrier family 22 member 6 Oryctolagus cuniculus 44-48 13129851-0 2004 Interaction of the metal chelator DMPS with OAT1 and OAT3 in intact isolated rabbit renal proximal tubules. Unithiol 34-38 solute carrier family 22 member 8 Oryctolagus cuniculus 53-57 13129851-12 2004 This is the first evidence showing that both OAT1 and OAT3 can transport DMPS across the basolateral membrane of RPT. Unithiol 73-77 solute carrier family 22 member 6 Oryctolagus cuniculus 45-49 13129851-12 2004 This is the first evidence showing that both OAT1 and OAT3 can transport DMPS across the basolateral membrane of RPT. Unithiol 73-77 solute carrier family 22 member 8 Oryctolagus cuniculus 54-58 12391276-2 2002 To evaluate the involvement of the organic anion transporter 1 (OAT1) in the renal flux of DMPS, we examined the effect of DMPS on transport mediated by the rabbit ortholog of OAT1 and compared these characteristics with those observed in intact isolated rabbit proximal tubules. Unithiol 91-95 solute carrier family 22 member 6 Oryctolagus cuniculus 35-62 12391276-2 2002 To evaluate the involvement of the organic anion transporter 1 (OAT1) in the renal flux of DMPS, we examined the effect of DMPS on transport mediated by the rabbit ortholog of OAT1 and compared these characteristics with those observed in intact isolated rabbit proximal tubules. Unithiol 91-95 solute carrier family 22 member 6 Oryctolagus cuniculus 64-68 12391276-2 2002 To evaluate the involvement of the organic anion transporter 1 (OAT1) in the renal flux of DMPS, we examined the effect of DMPS on transport mediated by the rabbit ortholog of OAT1 and compared these characteristics with those observed in intact isolated rabbit proximal tubules. Unithiol 123-127 solute carrier family 22 member 6 Oryctolagus cuniculus 176-180 12237339-4 2002 Xenopus laevis oocytes expressing rat Oat1 showed increased uptake of [(14)C]MeHg when complexed with either NAC or DMPS but not when complexed with L-cysteine, glutathione, dimercaptosuccinate, penicillamine, or gamma-glutamylcysteine. Unithiol 116-120 solute carrier family 22 member 6 Rattus norvegicus 38-42 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. Unithiol 56-60 solute carrier family 22 member 6 Rattus norvegicus 0-4 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. Unithiol 56-60 solute carrier family 22 member 6 Rattus norvegicus 106-110 12237339-8 2002 Conversely, efflux of [(3)H]PAH from Oat1-expressing oocytes was trans-stimulated by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a mercapturic acid, indicating that these are transported solutes. Unithiol 106-110 solute carrier family 22 member 6 Rattus norvegicus 37-41 12237339-10 2002 These results indicate that the MeHg antidotes NAC and DMPS and their mercaptide complexes are transported by Oat1 but are comparatively poor substrates for Oat3. Unithiol 55-59 solute carrier family 22 member 8 Rattus norvegicus 157-161 9929493-1 1999 Lipid activation of protein kinase C alpha (PKC alpha) was studied by using a model mixture containing 1, 2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1, 2-dimyristoyl-sn-glycero-3-phosphoserine (DMPS), and 1, 2-dimyristoyl-sn-glycerol (1,2-DMG). Unithiol 201-205 protein kinase C alpha Homo sapiens 20-42 12100989-5 2002 In the current study, based on those earlier findings, the effect of 1,2-dimyristoyl-3-phosphatidylserine (DMPS) on the transdermal transport of insulin by electroporation was examined. Unithiol 107-111 insulin Homo sapiens 145-152 12100989-9 2002 Results show that when electroporation was carried out in the presence of DMPS, there was greater than 20-fold enhancement of insulin transport. Unithiol 74-78 insulin Homo sapiens 126-133 9929493-1 1999 Lipid activation of protein kinase C alpha (PKC alpha) was studied by using a model mixture containing 1, 2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1, 2-dimyristoyl-sn-glycero-3-phosphoserine (DMPS), and 1, 2-dimyristoyl-sn-glycerol (1,2-DMG). Unithiol 201-205 protein kinase C alpha Homo sapiens 44-53 2177310-1 1990 Sodium dimercaptopropanesulphonate (DMPS) and sodium dimercaptosuccinate (DMS) were discovered to be effective antidotes for acute poisoning of insecticides SCD [sodium ammonium dimethyl-2-(propane-1,3-dithiosulfate) monohydrate], nereistoxin (4-N,N-dimethylamino-1,2-dithiolane) and cartap (dihydronereistoxin dicarbamate). Unithiol 36-40 stearoyl-Coenzyme A desaturase 1 Mus musculus 157-160 8198824-12 1994 DMPS treatment, administered by intravenous and oral route, was shown to be an effective alternative for BAL in life-threatening mercuric chloride intoxication. Unithiol 0-4 poly(ADP-ribose) polymerase family member 9 Homo sapiens 105-108 1664200-7 1991 Treatment with D-PEN, DMSA, DMPS, and bucillamine (1.2 mmol/kg) significantly prevented increases in the urinary excretion of protein, AST, and glucose and the BUN level after AuTM (0.026 mmol/kg) injection. Unithiol 28-32 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 135-138 9765315-7 1998 The urinary mercury greatly increased during those periods when DMPS was administered (1754, 314, and 173 microgram/24 h for the periods 1, 2 and 3, compared with 106, 48 and 53 microgram/24 h on the corresponding no-treatment periods). Unithiol 64-68 period circadian regulator 2 Homo sapiens 129-147 2177310-5 1990 The therapeutic effect of DMPS was also demonstrated in SCD-poisoned conscious rabbits. Unithiol 26-30 stearoyl-Coenzyme A desaturase 1 Mus musculus 56-59 2177310-6 1990 DMPS 62.5 mg/kg or DMS 500 mg/kg iv completely antagonized the neuromuscular blockade and respiratory depression caused by SCD, nereistoxin and cartap in anesthetized rabbits. Unithiol 0-4 stearoyl-Coenzyme A desaturase 1 Mus musculus 123-126 2177310-2 1990 In mice, DMPS (250 mg/kg) or DMS (1000 mg/kg) ip 20 min before SCD increased LD50 of ig SCD from 97 to 374 or 251 mg/kg, respectively. Unithiol 9-13 stearoyl-Coenzyme A desaturase 1 Mus musculus 88-91 32795589-5 2021 RESULTS: EWAS identified genes, including musashi RNA binding protein 2 (MSI2), associated with atopy, which contained enriched DMPs that that genetically affect atopy. Unithiol 128-132 musashi RNA binding protein 2 Homo sapiens 42-71 32795589-5 2021 RESULTS: EWAS identified genes, including musashi RNA binding protein 2 (MSI2), associated with atopy, which contained enriched DMPs that that genetically affect atopy. Unithiol 128-132 musashi RNA binding protein 2 Homo sapiens 73-77 32795589-7 2021 Regarding tissue eosinophilia, EWAS identified genes including CAMK1D with enriched DMPs directly contributing to tissue eosinophilia at the gene level. Unithiol 84-88 calcium/calmodulin dependent protein kinase ID Homo sapiens 63-69 34895303-10 2021 Seven of these DMPs (25%) could be allocated to a gene that was previously associated with cardiovascular diseases (HDAC4, IGF2BP3, CASZ1, SDK1, PCDHGA1, DIO3, PTPRN2). Unithiol 15-19 histone deacetylase 4 Homo sapiens 116-121 33769968-8 2021 Functional analysis of genes with a minimum of two DMPs showed involvement in antigen binding, transcriptional regulation, cell adhesion, IFN-gamma pathway, type I IFN pathway, antigen presentation, EB virus infection, human T-lymphotropic virus type 1 virus infection, and metabolic disease-related pathways. Unithiol 51-55 interferon gamma Homo sapiens 138-147 33032082-7 2021 These novel DMPs were found to set off the release of higher levels of tumour necrosis factor alpha (TNF-alpha) than Murabutide, which is a well-known NOD2 agonist. Unithiol 12-16 tumor necrosis factor Homo sapiens 101-110 33032082-7 2021 These novel DMPs were found to set off the release of higher levels of tumour necrosis factor alpha (TNF-alpha) than Murabutide, which is a well-known NOD2 agonist. Unithiol 12-16 nucleotide binding oligomerization domain containing 2 Homo sapiens 151-155 33032082-8 2021 Molecular docking studies indicate that all these DMPs bind well to NOD2 receptor with similar dock scores (binding energy) through a number of hydrogen bonding and hydrophobic/pi interactions with several crucial residues of the receptor. Unithiol 50-54 nucleotide binding oligomerization domain containing 2 Homo sapiens 68-72 34895303-10 2021 Seven of these DMPs (25%) could be allocated to a gene that was previously associated with cardiovascular diseases (HDAC4, IGF2BP3, CASZ1, SDK1, PCDHGA1, DIO3, PTPRN2). Unithiol 15-19 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 123-130 34895303-10 2021 Seven of these DMPs (25%) could be allocated to a gene that was previously associated with cardiovascular diseases (HDAC4, IGF2BP3, CASZ1, SDK1, PCDHGA1, DIO3, PTPRN2). Unithiol 15-19 castor zinc finger 1 Homo sapiens 132-137 34895303-10 2021 Seven of these DMPs (25%) could be allocated to a gene that was previously associated with cardiovascular diseases (HDAC4, IGF2BP3, CASZ1, SDK1, PCDHGA1, DIO3, PTPRN2). Unithiol 15-19 sidekick cell adhesion molecule 1 Homo sapiens 139-143 34895303-10 2021 Seven of these DMPs (25%) could be allocated to a gene that was previously associated with cardiovascular diseases (HDAC4, IGF2BP3, CASZ1, SDK1, PCDHGA1, DIO3, PTPRN2). Unithiol 15-19 protocadherin gamma subfamily A, 1 Homo sapiens 145-152 34895303-10 2021 Seven of these DMPs (25%) could be allocated to a gene that was previously associated with cardiovascular diseases (HDAC4, IGF2BP3, CASZ1, SDK1, PCDHGA1, DIO3, PTPRN2). Unithiol 15-19 iodothyronine deiodinase 3 Homo sapiens 154-158 34895303-10 2021 Seven of these DMPs (25%) could be allocated to a gene that was previously associated with cardiovascular diseases (HDAC4, IGF2BP3, CASZ1, SDK1, PCDHGA1, DIO3, PTPRN2). Unithiol 15-19 protein tyrosine phosphatase receptor type N2 Homo sapiens 160-166 34117263-4 2021 We then used linear models to identify DMPs associated with CRP concentrations. Unithiol 39-43 C-reactive protein Homo sapiens 60-63 34098319-9 2021 Targeted deep bisulfite sequencing of eight DMPs (associated with three genes; CMIP, ST3GAL1 and DAPK3) in an independent PE cohort validated two DMPs in the CMIP gene. Unithiol 146-150 c-Maf inducing protein Homo sapiens 158-162 34117263-8 2021 We subsequently identified 14 novel DMPs associated with CRP. Unithiol 36-40 C-reactive protein Homo sapiens 57-60 35537341-4 2022 We found differentially methylated DNA positions (DMPs) and regions embedding DMPs associated with either disease status, C9ORF72 or FUS mutation status. Unithiol 78-82 C9orf72-SMCR8 complex subunit Homo sapiens 122-129 35537341-4 2022 We found differentially methylated DNA positions (DMPs) and regions embedding DMPs associated with either disease status, C9ORF72 or FUS mutation status. Unithiol 78-82 FUS RNA binding protein Homo sapiens 133-136 35537341-6 2022 Furthermore, we could demonstrate co-localization of DMPs with an ALS-associated GWAS region near the SCN7A/SCN9A and XIRP2 genes. Unithiol 53-57 sodium voltage-gated channel alpha subunit 7 Homo sapiens 102-107 35537341-6 2022 Furthermore, we could demonstrate co-localization of DMPs with an ALS-associated GWAS region near the SCN7A/SCN9A and XIRP2 genes. Unithiol 53-57 sodium voltage-gated channel alpha subunit 9 Homo sapiens 108-113 35537341-6 2022 Furthermore, we could demonstrate co-localization of DMPs with an ALS-associated GWAS region near the SCN7A/SCN9A and XIRP2 genes. Unithiol 53-57 xin actin binding repeat containing 2 Homo sapiens 118-123 35256034-11 2022 DMPs in STXBP6, and PF4 DMR, mediated the association between the maternal intervention and the cognitive domain at 12 months of age. Unithiol 0-4 syntaxin binding protein 6 Homo sapiens 8-14 35177097-8 2022 The small number of sex-specific DMPs that were affected by GAHT were those that become sex-specific during the lifetime, known as sex-and-age DMPs, including DMRs in PRR4 and VMP1 genes. Unithiol 33-37 proline rich 4 Homo sapiens 167-171 35177097-8 2022 The small number of sex-specific DMPs that were affected by GAHT were those that become sex-specific during the lifetime, known as sex-and-age DMPs, including DMRs in PRR4 and VMP1 genes. Unithiol 33-37 vacuole membrane protein 1 Homo sapiens 176-180 35177097-8 2022 The small number of sex-specific DMPs that were affected by GAHT were those that become sex-specific during the lifetime, known as sex-and-age DMPs, including DMRs in PRR4 and VMP1 genes. Unithiol 143-147 proline rich 4 Homo sapiens 167-171 35177097-8 2022 The small number of sex-specific DMPs that were affected by GAHT were those that become sex-specific during the lifetime, known as sex-and-age DMPs, including DMRs in PRR4 and VMP1 genes. Unithiol 143-147 vacuole membrane protein 1 Homo sapiens 176-180 35260870-4 2022 In this study, single-molecule Forster resonance energy transfer (smFRET) and fluorescence correlation spectroscopy (FCS) were applied to detect the conformational changes and intermolecular interactions of full-length Tau in the presence of different concentrations of 1,2-dimyristoyl-sn-glycero-3-phosphatidylserine (DMPS) vesicles. Unithiol 319-323 microtubule associated protein tau Homo sapiens 219-222 35260870-5 2022 The results show that the conformation of Tau becomes expanded with opening of the N-terminal and C-terminal domains of Tau upon binding to DMPS. Unithiol 140-144 microtubule associated protein tau Homo sapiens 42-45 35260870-5 2022 The results show that the conformation of Tau becomes expanded with opening of the N-terminal and C-terminal domains of Tau upon binding to DMPS. Unithiol 140-144 microtubule associated protein tau Homo sapiens 120-123 35260870-6 2022 At low DMPS concentrations, Tau forms oligomers with a partially extended conformation which facilitates the amyloid fibrillization process. Unithiol 7-11 microtubule associated protein tau Homo sapiens 28-31 35260870-7 2022 At high DMPS concentrations, Tau monomer binds to lipid membranes in a fully expanded conformation at low density thus inhibiting intermolecular aggregation. Unithiol 8-12 microtubule associated protein tau Homo sapiens 29-32