PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9232632-4	1997	The order of defibrillization of A beta 1-40 fibrils by metal cations was: Ca2+ and Zn2+ (IC50 = 100 microM) > Mg3+ (IC50 = 300 microM) > Al3+ (IC50 = 1.1 mM).	ALUMINUM ION	138-142	AA1	Homo sapiens	33-41
8761343-5	1996	This observed APP processing was significantly enhanced by Ca2+, Mg2+, or Mn2+ at 1 mM concentration and modulated in concentration dependent manners by metal ions such as Ca2+, Zn2+, Fe2+/Fe3+, Al3+, or a tacrine, a centrally active cholinesterase inhibitor.	ALUMINUM ION	195-199	butyrylcholinesterase	Homo sapiens	234-248
8915773-4	1996	This stimulation was inhibited by deferoxamine, a chelator of Al3+, suggesting that PLD activation involves fluoride-sensitive G proteins.	ALUMINUM ION	62-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
9112760-2	1997	Picomolar Al3+ concentrations inhibited the GTPase activity of ras p21 in an Mg(2+)-dependent manner, consistent with an Al3+/Mg2+ competition mechanism.	ALUMINUM ION	10-14	H3 histone pseudogene 16	Homo sapiens	67-70
9112760-2	1997	Picomolar Al3+ concentrations inhibited the GTPase activity of ras p21 in an Mg(2+)-dependent manner, consistent with an Al3+/Mg2+ competition mechanism.	ALUMINUM ION	121-125	H3 histone pseudogene 16	Homo sapiens	67-70
9112760-4	1997	Kinetic studies demonstrated that the mode of Al(3+)-induced inhibition of ras p21 GTPase activity changed from competitive to mixed non-competitive as the number of ras p21 turnovers increased.	ALUMINUM ION	46-52	H3 histone pseudogene 16	Homo sapiens	79-82
9112760-4	1997	Kinetic studies demonstrated that the mode of Al(3+)-induced inhibition of ras p21 GTPase activity changed from competitive to mixed non-competitive as the number of ras p21 turnovers increased.	ALUMINUM ION	46-52	H3 histone pseudogene 16	Homo sapiens	170-173
9112760-5	1997	Further dissection of the ras p21 cycle revealed that Mg(2+)-dependent GDP/GTP exchange was the Al(3+)-sensitive step.	ALUMINUM ION	96-102	H3 histone pseudogene 16	Homo sapiens	30-33
9108291-7	1997	Normal Al3+ tolerance was restored by expression of the MAP kinase gene SLT2.	ALUMINUM ION	7-11	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	72-76
9108291-8	1997	Strains carrying deletions of the SLT2 gene, or of the gene for the corresponding MAP kinase kinase SLK1, showed sensitivity to Al3+.	ALUMINUM ION	128-132	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	34-38
9108291-8	1997	Strains carrying deletions of the SLT2 gene, or of the gene for the corresponding MAP kinase kinase SLK1, showed sensitivity to Al3+.	ALUMINUM ION	128-132	mitogen-activated protein kinase kinase kinase BCK1	Saccharomyces cerevisiae S288C	100-104
9108291-9	1997	These results indicate that the SLT2 MAP kinase signal transduction pathway is required for yeast to sense and respond to Al3+ stress.	ALUMINUM ION	122-126	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	32-36
8600461-14	1996	Cd2+ and Al3+ ions also inhibited the ability of TFIIIA to bind complementary single-stranded DNA and promote renaturation, as measured by Tris-phosphate agarose gel electrophoresis.	ALUMINUM ION	9-13	general transcription factor IIIA	Homo sapiens	49-55
12228515-8	1995	Additionally, Al3+-mediated interference with the normal kinetics of F-actin filament assembly/disassembly could precipitate subsequent disorganization of associated cytoskeletal structures and promote altered expression of cytoskeletal proteins.	ALUMINUM ION	14-18	actin	Glycine max	71-76
8586971-2	1995	Interactions of apo- and holo-transferrin with Al3+ were studied by circular dichroism (CD), UV-visible, and fluorescence spectrometry.	ALUMINUM ION	47-51	transferrin	Homo sapiens	30-41
8586971-3	1995	Binding of Al3+ to both metal-ion binding sites of apo-transferrin was confirmed by fluorescence studies.	ALUMINUM ION	11-15	transferrin	Homo sapiens	55-66
8586971-5	1995	An increase in tryptophan fluorescence (lambda max at 330 nm) by excitation at either 280 or 295 nm was observed after Al3+ interaction with apo-transferrin.	ALUMINUM ION	119-123	transferrin	Homo sapiens	145-156
8586971-9	1995	The CD spectrum of apo-transferrin was slightly affected in the far UV by Al3+ binding, but a salient change was noted in the near UV at approximately 288 nm where tyrosine and tryptophan absorb.	ALUMINUM ION	74-78	transferrin	Homo sapiens	23-34
8586971-10	1995	It is concluded that a small conformational change in the protein was induced by Al3+ binding to apo-transferrin.	ALUMINUM ION	81-85	transferrin	Homo sapiens	101-112
7669921-2	1995	CD spectroscopic studies on two synthetic fragments of the human neurofilament protein midsized subunit (NF-M), and their alanine-for-serine-substituted and/or serine-phosphorylated derivatives showed the formation of stable, citric acid resistant complexes of Al3+ with peptide ligands [M. Hollosi, Z. M. Shen, A. Perczel, and G. D. Fasman (1994) Proc.	ALUMINUM ION	261-265	neurofilament medium chain	Homo sapiens	65-103
7669921-2	1995	CD spectroscopic studies on two synthetic fragments of the human neurofilament protein midsized subunit (NF-M), and their alanine-for-serine-substituted and/or serine-phosphorylated derivatives showed the formation of stable, citric acid resistant complexes of Al3+ with peptide ligands [M. Hollosi, Z. M. Shen, A. Perczel, and G. D. Fasman (1994) Proc.	ALUMINUM ION	261-265	neurofilament medium chain	Homo sapiens	105-109
7580055-1	1995	Transferrin saturated with Al3+ subjected to isoelectric focusing (IEF) in a pH gradient can be separated into four fractions, representing the apotransferrin, transferrin with aluminum at the metal binding site in the C- or N-terminal lobe, or both.	ALUMINUM ION	27-31	transferrin	Homo sapiens	0-11
1497609-0	1992	Uptake of Al3+ into the N-lobe of human serum transferrin.	ALUMINUM ION	10-14	transferrin	Homo sapiens	46-57
7827330-0	1994	Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species.	ALUMINUM ION	38-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
7827330-3	1994	The interaction between Al3+ and gamma-peripheral sites of the enzyme produces AChE structural modifications as evidenced by circular dichroism measurements.	ALUMINUM ION	24-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
8068639-0	1994	Study of Al3+ binding and conformational properties of the alanine-substituted C-terminal domain of the NF-M protein and its relevance to Alzheimer"s disease.	ALUMINUM ION	9-13	neurofilament medium chain	Homo sapiens	104-108
8014635-2	1994	In both cases the action of Al3+ was inhibitory and the extent of inhibition was dependent on Al3+ concentration and the length of incubation of Al3+/phosvitin mixtures.	ALUMINUM ION	28-32	casein kinase 2 beta	Homo sapiens	150-159
8014635-3	1994	The inhibition profiles of dephosphorylation of phosvitin (50 micrograms/ml) showed IC50 values of 15 and 2 microM Al3+ at 1 and 48 hr incubation time, respectively.	ALUMINUM ION	115-119	casein kinase 2 beta	Homo sapiens	48-57
8014635-6	1994	Exposure of fluorescein 5-isothiocyanate-labeled phosvitin to Al3+ resulted in: a) the failure of the protein to migrate into sodium dodecyl sulfate containing polyacrylamide gels and b) the decrease of the fluorescence emission of the bound fluorescein.	ALUMINUM ION	62-66	casein kinase 2 beta	Homo sapiens	49-58
7816003-3	1994	Mouse bone marrow cells were stimulated in vitro with erythropoietin (Epo) in the presence of Al3+ ion and erythroid colony-forming units were then determined.	ALUMINUM ION	94-98	erythropoietin	Mus musculus	54-68
7816003-3	1994	Mouse bone marrow cells were stimulated in vitro with erythropoietin (Epo) in the presence of Al3+ ion and erythroid colony-forming units were then determined.	ALUMINUM ION	94-98	erythropoietin	Mus musculus	70-73
1476184-1	1992	This in vitro study evaluates the effect of aluminum (Al3+) on osteocalcin, a small protein that is produced by the osteoblast.	ALUMINUM ION	54-58	bone gamma-carboxyglutamate protein	Homo sapiens	63-74
1476184-2	1992	After stimulation with various doses of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; 10(-11) to 10(-9) M], osteocalcin was consistently lower in the culture medium of ROS 17/2 osteoblastic cells conditioned with 5 microM Al(3+)-saturated transferrin (AlTR) than in apotransferrin (ApoTR)-treated controls.	ALUMINUM ION	215-221	bone gamma-carboxyglutamate protein	Homo sapiens	101-112
1476184-5	1992	However, in the same experiment, lower doses of AlTR or ApoTR (1.6 and 3.2 microM) yielded different results, i.e., increased medium and intracellular contents of osteocalcin in the Al(3+)-treated cells.	ALUMINUM ION	182-188	bone gamma-carboxyglutamate protein	Homo sapiens	163-174
1526019-1	1992	An equilibrium model for the speciation of Al3+ in normal serum has been developed in which 81% of the aluminum is bound to transferrin.	ALUMINUM ION	43-47	transferrin	Homo sapiens	124-135
1435620-4	1992	At the pathophysiological level of 0.5 mM, Al3+ only inhibits brain mitochondrial MAO-A but at the higher level of 2.5 mM, it inhibits both forms of MAO in brain as well as liver mitochondria.	ALUMINUM ION	43-47	monoamine oxidase A	Rattus norvegicus	82-87
1435620-4	1992	At the pathophysiological level of 0.5 mM, Al3+ only inhibits brain mitochondrial MAO-A but at the higher level of 2.5 mM, it inhibits both forms of MAO in brain as well as liver mitochondria.	ALUMINUM ION	43-47	monoamine oxidase A	Rattus norvegicus	82-85
7832774-7	1995	305, 491-498]: 5-50 microM Al3+ increased MIPP activity towards both Ins(1,3,4,5)P4 (by 30%) and Ins(1,3,4,5,6)P5 (by up to 500%), without affecting metabolism of InsP6.	ALUMINUM ION	27-31	IAP promoted placental gene	Mus musculus	42-46
7832774-7	1995	305, 491-498]: 5-50 microM Al3+ increased MIPP activity towards both Ins(1,3,4,5)P4 (by 30%) and Ins(1,3,4,5,6)P5 (by up to 500%), without affecting metabolism of InsP6.	ALUMINUM ION	27-31	inositol hexaphosphate kinase 1	Mus musculus	163-168
7832774-8	1995	Higher concentrations of Al3+ inhibited metabolism of all three substrates, and in the case of InsP6, Al3+ altered the pattern of accumulating products.	ALUMINUM ION	102-106	inositol hexaphosphate kinase 1	Mus musculus	95-100
7832774-9	1995	When 1-50 microM Al3+ was present, InsP6 became a less effective inhibitor of Ins(1,3,4,5)P4 3-phosphatase activity; this effect did not depend on the presence of cellular membranes, contrary to a previous proposal.	ALUMINUM ION	17-21	inositol hexaphosphate kinase 1	Mus musculus	35-40
7832774-10	1995	The latter phenomenon largely explains how, in a cell-free system where Ins(1,3,4,5)P4 3-phosphatase is inhibited by endogenous InsP6, the addition of Al3+ can apparently increase the enzyme activity.	ALUMINUM ION	151-155	inositol hexaphosphate kinase 1	Mus musculus	128-133
7549986-3	1994	The IC50 demonstrates that Al3+ is a potent inhibitor of AChE.	ALUMINUM ION	27-31	acetylcholinesterase	Bos taurus	57-61
7845378-3	1994	The data also showed that MAO-A inhibition by Al varies with free Al3+ concentration and different forms of Al under different pH conditions.	ALUMINUM ION	66-70	monoamine oxidase A	Rattus norvegicus	26-31
8149616-3	1994	Consideration of the effect of competitive binding of alkaline earth metal ions to citrate on Al3+ binding and of a set of transferrin-Al3+ stability constants leads to the conclusion that the proportions are in close agreement with previously published results.	ALUMINUM ION	135-139	transferrin	Homo sapiens	123-134
8149616-4	1994	We conclude on the basis of stability constants that, of the Al3+ in blood serum, approximately 89% (+/- 5%) binds to transferrin and approximately 11% (+/- 5%) to citrate.	ALUMINUM ION	61-65	transferrin	Homo sapiens	118-129
8380642-6	1993	A beta P-channel current (either CS+ or Ca2+ as charge carriers) is blocked reversibly by tromethamine (millimolar range) and irreversibly by Al3+ (micromolar range).	ALUMINUM ION	142-146	amyloid beta precursor protein	Homo sapiens	0-6
8380642-7	1993	The inhibition of the A beta P-channel current by these two substances depends on transmembrane potential, suggesting that the mechanism of blockade involves direct interaction between tromethamine (or Al3+) and sites within the A beta P channel.	ALUMINUM ION	202-206	amyloid beta precursor protein	Homo sapiens	22-28
8380642-7	1993	The inhibition of the A beta P-channel current by these two substances depends on transmembrane potential, suggesting that the mechanism of blockade involves direct interaction between tromethamine (or Al3+) and sites within the A beta P channel.	ALUMINUM ION	202-206	amyloid beta precursor protein	Homo sapiens	229-235
1738004-7	1992	One millimolar Al3+ inhibited 67% of the MP-70 activity, but did not affect the MP-100 and MP-130 activities.	ALUMINUM ION	15-19	transmembrane 9 superfamily member 1	Homo sapiens	41-46
1675963-9	1991	Spontaneous tumor necrosis factor-alpha (TNF-alpha) production was enhanced by Co2+ and Al3+, but decreased by Cd2+.	ALUMINUM ION	88-92	tumor necrosis factor	Homo sapiens	12-39
1490427-4	1992	In the blood plasma, citrate is the main small molecule carrier and transferrin the main protein carrier of Al3+.	ALUMINUM ION	108-112	transferrin	Homo sapiens	68-79
1747128-2	1991	The binding of Al3+ by human serum transferrin has been investigated by u.v.-visible difference spectroscopy.	ALUMINUM ION	15-19	transferrin	Homo sapiens	35-46
1747128-6	1991	Competitive assays of binding of Al3+ to transferrin in the presence of citrate and human serum albumin at molar ratios corresponding to those found in normal plasma showed that a considerable amount of Al3+ was not bound to transferrin.	ALUMINUM ION	33-37	transferrin	Homo sapiens	41-52
1747128-10	1991	These results therefore suggest that, although transferrin at pH 7.4 is the major Al(3+)-binding component of plasma, an appreciable amount of Al3+ present in patients on haemodialysis may be bound to albumin.	ALUMINUM ION	82-88	transferrin	Homo sapiens	47-58
1647442-0	1991	Al3+ versus Ca2+ ion binding to methionine and tyrosine spin-labeled bovine brain calmodulin.	ALUMINUM ION	0-4	calmodulin	Bos taurus	82-92
2037846-1	1991	The kinetics of release of Al3+ from human serum dialuminum transferrin (Al2Tf) to citrate were investigated at 37 degrees C, pH 7.4, mu = 0.7 M, by difference UV spectrophotometry.	ALUMINUM ION	27-31	transferrin	Homo sapiens	60-71
1899388-10	1991	These observations show that the interaction of Al3+ and F-, in the presence of Mg2+, may be quite different between the hormone-sensitive G proteins, which bind aluminum fluoride, and the GTP-binding proteins as a whole, which include EF-Tu.	ALUMINUM ION	48-52	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	236-241
1675963-9	1991	Spontaneous tumor necrosis factor-alpha (TNF-alpha) production was enhanced by Co2+ and Al3+, but decreased by Cd2+.	ALUMINUM ION	88-92	tumor necrosis factor	Homo sapiens	41-50
34837756-2	2022	Al3+ can inhibit the expression of ADAM10, a key enzyme of the nonamyloid pathway, but its mechanism of toxicity has not been fully elucidated.	ALUMINUM ION	0-4	ADAM metallopeptidase domain 10	Homo sapiens	35-41
1653697-3	1991	There was a dose dependent inhibition of CaM activity when CaM (from normal and Cd exposed rats) was incubated with different molar ratios of aluminium (Al3+), lead (Pb2+), manganese (Mn2+) and vanadium (V5+).	ALUMINUM ION	153-157	calmodulin 1	Rattus norvegicus	41-44
1653697-3	1991	There was a dose dependent inhibition of CaM activity when CaM (from normal and Cd exposed rats) was incubated with different molar ratios of aluminium (Al3+), lead (Pb2+), manganese (Mn2+) and vanadium (V5+).	ALUMINUM ION	153-157	calmodulin 1	Rattus norvegicus	59-62
34973572-6	2022	It is found that Al3+ and Ca2+ cations from the aluminium oxide (Al2O3) and hydroxyapatite (Ca5(PO4)3OH) present in the fluorescent lamp waste compete with REEs in reacting with TBP-HNO3 adduct; hence, REE extractions from real fluorescent lamp waste is less than previously reported extractions from synthetic feeds.	ALUMINUM ION	17-21	TATA-box binding protein	Homo sapiens	178-181
34837756-5	2022	RESULTS: Al3+ reduced the expressions of RARalpha, RARbeta and ADAM10.	ALUMINUM ION	9-13	retinoic acid receptor alpha	Homo sapiens	41-49
34837756-5	2022	RESULTS: Al3+ reduced the expressions of RARalpha, RARbeta and ADAM10.	ALUMINUM ION	9-13	retinoic acid receptor alpha	Homo sapiens	51-58
34837756-5	2022	RESULTS: Al3+ reduced the expressions of RARalpha, RARbeta and ADAM10.	ALUMINUM ION	9-13	ADAM metallopeptidase domain 10	Homo sapiens	63-69
34837756-8	2022	CONCLUSION: Al3+ inhibits ADAM10 expression through RARalpha and RARbeta and results in a decrease in the nonamyloid pathway.	ALUMINUM ION	12-16	ADAM metallopeptidase domain 10	Homo sapiens	26-32
34837756-8	2022	CONCLUSION: Al3+ inhibits ADAM10 expression through RARalpha and RARbeta and results in a decrease in the nonamyloid pathway.	ALUMINUM ION	12-16	retinoic acid receptor alpha	Homo sapiens	52-60
34837756-8	2022	CONCLUSION: Al3+ inhibits ADAM10 expression through RARalpha and RARbeta and results in a decrease in the nonamyloid pathway.	ALUMINUM ION	12-16	retinoic acid receptor alpha	Homo sapiens	65-72
34502905-8	2021	In brief, using Co2+, Cu2+, Al3+, and Mn2+ as the hybridization materials for immobilization could improve the catalytic properties and stability of the free PLA1, suggesting a promising method for a wider application of PLA1 in many fields such as food, cosmetics, and the pharmaceutical industry.	ALUMINUM ION	28-32	POU class 2 homeobox 3	Homo sapiens	158-162
34749386-2	2021	HT has been confirmed to possess high specificity toward Ga3+ over other metal ions (including Al3+ and In3+) via a distinct fluorescence light-up response.	ALUMINUM ION	95-99	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	57-60
34730585-3	2021	The limit of detection (LOD) of NBP toward Al3+ was detected to be 80 nM.	ALUMINUM ION	43-47	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	32-35
34730585-4	2021	The binding ratio of NBP with Al3+ ions was obtained as 1 : 2 on the basis of Job"s plot with the association constant Ka value of 4.22 x 1010 M-1/2.	ALUMINUM ION	30-34	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	21-24
34730585-5	2021	The plausible complexation mechanism of NBP toward Al3+ ions was validated by the density functional theory (DFT) and IR spectrum.	ALUMINUM ION	51-55	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	40-43
34730585-6	2021	In addition, in situ formed "NBP + Al3+" could be utilized as the second sensor for selective recognition of F-via fluorescence quenching with a low detection limit (44 nM).	ALUMINUM ION	35-39	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	29-32
34730585-7	2021	Furthermore, the cell imaging experiments of probe NBP in HeLa cells have successfully demonstrated that NBP could serve as an indicator for monitoring Al3+ ions in living cells.	ALUMINUM ION	152-156	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	51-54
34730585-7	2021	Furthermore, the cell imaging experiments of probe NBP in HeLa cells have successfully demonstrated that NBP could serve as an indicator for monitoring Al3+ ions in living cells.	ALUMINUM ION	152-156	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	105-108
34730585-8	2021	On top of that, NBP could be used to prepare simple test paper strips for quickly and qualitatively detecting a trace amount of Al3+ ions in a visible manner.	ALUMINUM ION	128-132	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	16-19
34668717-5	2021	Crystal structures of MAT2A with analogues of AdoMet and pyrophosphate were obtained in the presence of Mg2+, Al3+, and F-.	ALUMINUM ION	110-114	methionine adenosyltransferase 2A	Homo sapiens	22-27
34783530-3	2021	Fe3+ and Al3+ induced tau aggregation while several trivalent metal ions such as Cr3+, La3+, and V3+ had no discernable effect on tau aggregation.	ALUMINUM ION	9-13	microtubule associated protein tau	Homo sapiens	22-25
34730585-2	2021	NBP exhibited high selectivity toward Al3+ along with naked-eye color changes and prominent fluorescence enhancement.	ALUMINUM ION	38-42	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	0-3
34502905-8	2021	In brief, using Co2+, Cu2+, Al3+, and Mn2+ as the hybridization materials for immobilization could improve the catalytic properties and stability of the free PLA1, suggesting a promising method for a wider application of PLA1 in many fields such as food, cosmetics, and the pharmaceutical industry.	ALUMINUM ION	28-32	POU class 2 homeobox 3	Homo sapiens	221-225
35405193-7	2022	Oxidative stress was profoundly induced dose-dependently and was highest at 2 mg ml-1 or g-1 of Al3+ and nano-Al2O3 when superoxide radical formation, proline induction, activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX), and glutathione reductase (GR) and membrane lipid peroxidation were measured.	ALUMINUM ION	96-100	superoxide dismutase	Zea mays	184-204
34313127-8	2021	In the presence of Al3+, Sc3+, or H+, 1 is converted to (CoIII(TBDAP)(O2H)(MeCN))2+ (4), and further reaction with nitriles did not occur.	ALUMINUM ION	19-23	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	57-62
35405193-7	2022	Oxidative stress was profoundly induced dose-dependently and was highest at 2 mg ml-1 or g-1 of Al3+ and nano-Al2O3 when superoxide radical formation, proline induction, activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX), and glutathione reductase (GR) and membrane lipid peroxidation were measured.	ALUMINUM ION	96-100	superoxide dismutase	Zea mays	206-209
35405193-7	2022	Oxidative stress was profoundly induced dose-dependently and was highest at 2 mg ml-1 or g-1 of Al3+ and nano-Al2O3 when superoxide radical formation, proline induction, activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX), and glutathione reductase (GR) and membrane lipid peroxidation were measured.	ALUMINUM ION	96-100	peroxidase 1	Zea mays	228-238
35405193-7	2022	Oxidative stress was profoundly induced dose-dependently and was highest at 2 mg ml-1 or g-1 of Al3+ and nano-Al2O3 when superoxide radical formation, proline induction, activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX), and glutathione reductase (GR) and membrane lipid peroxidation were measured.	ALUMINUM ION	96-100	glutathione reductase 1	Zea mays	250-271
35405193-7	2022	Oxidative stress was profoundly induced dose-dependently and was highest at 2 mg ml-1 or g-1 of Al3+ and nano-Al2O3 when superoxide radical formation, proline induction, activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX), and glutathione reductase (GR) and membrane lipid peroxidation were measured.	ALUMINUM ION	96-100	glutathione reductase 1	Zea mays	273-275
35470905-3	2022	This article examines the energetic and structural properties of endo- and exohedral complexes of superphane with the following cations: H+ , Li+ , Na+ , K+ , Be2+ , Mg2+ , Ca2+ , B3+ , Al3+ , Ga3+ .	ALUMINUM ION	186-190	mannosidase endo-alpha	Homo sapiens	65-69
35364410-2	2022	In this work, a simple Schiff-base fluorescent probe NPP derived from naphthalimide and picolinohydrazide was rationally designed and prepared for efficient detection of Al3+.	ALUMINUM ION	170-174	proopiomelanocortin	Homo sapiens	53-56
35364410-3	2022	NPP exhibited prominent sensing behaviors toward Al3+ with low detection limit (LOD) (39 nM), rapid response time (1 min), strong binding affinity (4.02 x 104), good anti-interference characteristics and visual detection.	ALUMINUM ION	49-53	proopiomelanocortin	Homo sapiens	0-3
35364410-5	2022	In addition, the chelation mechanism of NPP with Al3+ ions was proposed and substantiated by the density functional theory (DFT) and time-dependent density functional theory (TD-DFT), IR spectrum and 1H NMR titration experiments.	ALUMINUM ION	49-53	proopiomelanocortin	Homo sapiens	40-43
35364410-6	2022	Furthermore, this "signal-on" probe NPP was efficiently utilized as a promising indicator for Al3+ detection in environmental and biological samples.	ALUMINUM ION	94-98	proopiomelanocortin	Homo sapiens	36-39
35468374-0	2022	Theoretical investigation on the fluorescence properties and ESIPT mechanism of the Al3+ ion sensor 1-((2-hydroxynaphthalen-1-yl)methylene)urea(OCN).	ALUMINUM ION	84-88	bone gamma-carboxyglutamate protein	Homo sapiens	144-147
35468374-1	2022	A new action mechanism for the fluorescent detection on the Al3+ ion of the sensitive 1-((2-hydroxynaphthalen-1-yl)methylene)urea(OCN) is theoretically studied.	ALUMINUM ION	60-64	bone gamma-carboxyglutamate protein	Homo sapiens	130-133
2777755-8	1989	Taken together with our previous finding that Al3+ enhances the NaF-induced Ca2+ mobilization in MOB 3-4 cells, these results suggest that F- combined with Al3+ (i.e., AlF4-) is a more potent stimulator of PGE2 synthesis in cells than F- alone, and that the AlF4- -enhanced PGE2 synthesis may be caused by an increase in cytosolic free Ca2+ concentration during activation of the G protein by AlF4-.	ALUMINUM ION	156-160	AF4/FMR2 family, member 4	Mus musculus	168-172
35019917-2	2022	It exhibited an excellent selective and sensitive CHEF-based recognition of trivalent metal ions M3+ (M = Fe, Al and Cr) over mono and di-valent and other trivalent metal ions with prominent enhancement in the absorption and fluorescence intensity for Fe3+ (669-fold), Al3+ (653-fold) and Cr3+ (667-fold) upon the addition of 2.6 equivalent of these metal ions in the probe in H2O/CH3CN (7 : 3, v/v, pH 7.2).	ALUMINUM ION	269-273	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	289-292
2565957-3	1989	At pH 2 it was the most amorphous forms which released Al3+ most rapidly.	ALUMINUM ION	55-59	polyhomeotic homolog 2	Homo sapiens	3-7
2777755-8	1989	Taken together with our previous finding that Al3+ enhances the NaF-induced Ca2+ mobilization in MOB 3-4 cells, these results suggest that F- combined with Al3+ (i.e., AlF4-) is a more potent stimulator of PGE2 synthesis in cells than F- alone, and that the AlF4- -enhanced PGE2 synthesis may be caused by an increase in cytosolic free Ca2+ concentration during activation of the G protein by AlF4-.	ALUMINUM ION	46-50	MOB family member 4, phocein	Mus musculus	97-104
33902402-5	2021	Thanks to the existence of electrically conductive CS-Al3+ networks, the resulting hybrid DN hydrogel exhibits excellent stretchability, fatigue resistance, transparency, and conductivity.	ALUMINUM ION	54-58	citrate synthase	Homo sapiens	51-53
3815806-0	1987	Transferrin binding of Al3+ and Fe3+.	ALUMINUM ION	23-27	transferrin	Homo sapiens	0-11
3815806-2	1987	Quantitative studies demonstrate that the protein transferrin (iron-free) is the strongest Al3+ binder in blood plasma.	ALUMINUM ION	91-95	transferrin	Homo sapiens	50-61
3815806-3	1987	Under plasma conditions of pH 7.4 and [HCO3-]27 mmol/L, the successive stability constant values for Al3+ binding to transferrin are log K1 = 12.9 and log K2 = 12.3.	ALUMINUM ION	101-105	transferrin	Homo sapiens	117-128
3815806-4	1987	When the concentration of total Al3+ in plasma is 1 mumol/L, the free Al3+ concentration permitted by transferrin is 10(-14.6) mol/L, less than that allowed by insoluble Al(OH)3, by Al(OH)2H2PO4, or by complexing with citrate.	ALUMINUM ION	32-36	transferrin	Homo sapiens	102-113
3815806-4	1987	When the concentration of total Al3+ in plasma is 1 mumol/L, the free Al3+ concentration permitted by transferrin is 10(-14.6) mol/L, less than that allowed by insoluble Al(OH)3, by Al(OH)2H2PO4, or by complexing with citrate.	ALUMINUM ION	70-74	transferrin	Homo sapiens	102-113
3815806-5	1987	Thus transferrin is the ultimate carrier of Al3+ in the blood.	ALUMINUM ION	44-48	transferrin	Homo sapiens	5-16
3806090-6	1986	In the blood, plasma transferrin steals both Fe3+ and Al3+ from citrate.	ALUMINUM ION	54-58	transferrin	Homo sapiens	21-32
3004381-3	1985	Al3+, Mn2+, Hg2+, and Cd2+ cannot be regarded as exclusive calmodulin antagonists or agonists, but rather interact with the phosphodiesterase itself.	ALUMINUM ION	0-4	calmodulin 1	Homo sapiens	59-69
3986284-0	1985	Ionic strength dependence of the inhibition of acetylcholinesterase activity by Al3+.	ALUMINUM ION	80-84	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-67
3986284-1	1985	Inhibition of acetylcholinesterase activity by Al3+ has been examined by initial velocity kinetics and by a first-order kinetic method.	ALUMINUM ION	47-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
6879151-3	1983	We examined the interrelation of soil environmental supply of Al3+(6H2O) to the food-plant-animal-human chain (e.g., in tea leaves, approximately 1000 mg L-1) and to identified health hazards.	ALUMINUM ION	62-66	immunoglobulin kappa variable 1-16	Homo sapiens	154-157
33969864-11	2021	The luminescence lifetime decay analysis manifested that a charge-transfer type complex was formed between 1 and Cr3+ and Fe3+ ions that resulted in huge luminescence quenching due to the efficient charge transfer involving the vacant d-orbitals, whereas for Al3+ ions having no vacant d-orbital, turn-on of luminescence occurred because of the increased rigidity of 1 upon complexation.	ALUMINUM ION	259-263	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	113-116
2463739-8	1988	While 1 mM F- suppresses PTH secretion by only 21%, and 10 microM Al3+ has virtually no effect at all, together they inhibit PTH release approximately to the level (63% inhibition) observed with 5 mM NaF alone.	ALUMINUM ION	66-70	parathyroid hormone	Bos taurus	125-128
3118356-4	1987	Moreover, NaF (in the presence of Al3+) and guanyl-5"-yl imidodiphosphate mediate strong activation of cyc- adenylyl cyclase provided the cholate extracts of brush border membranes are also present.	ALUMINUM ION	34-38	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	103-106
4029088-1	1985	It is known that the secretion of PTH is often impaired in association with aluminum (Al3+) accumulation in patients with renal failure.	ALUMINUM ION	86-90	parathyroid hormone	Homo sapiens	34-37
4029088-11	1985	These data provide a potential mechanism for the inhibition of PTH secretion by Al3+.	ALUMINUM ION	80-84	parathyroid hormone	Bos taurus	63-66
33229094-6	2021	Adsorption of p-ASA/ROX on the metal (hydro)oxide and clay minerals was affected by solution pH, co-existing metal ions (Ca2+, Mg2+, Al3+, Cu2+, Fe3+, and Zn2+), oxyanions (H2PO4-, HCO3-, and SO42-), and humic acid.	ALUMINUM ION	133-137	MAX network transcriptional repressor	Homo sapiens	14-23
33676709-6	2021	Under the optimum conditions, the fluorescence intensity increased with increasing of Al3+ concentrations in the range of 0.28-500.0 ng mL-1 with LOD (S/N = 3) of 0.09 ng mL-1.	ALUMINUM ION	86-90	L1 cell adhesion molecule	Mus musculus	136-140
33676709-6	2021	Under the optimum conditions, the fluorescence intensity increased with increasing of Al3+ concentrations in the range of 0.28-500.0 ng mL-1 with LOD (S/N = 3) of 0.09 ng mL-1.	ALUMINUM ION	86-90	L1 cell adhesion molecule	Mus musculus	171-175
32652343-7	2020	Furthermore, addition of Al3+ and Fe3+ decreased peroxidase (POD) activity and inhibited degradation of dichlorvos and malathion.	ALUMINUM ION	25-29	peroxidase 2-like	Cucumis sativus	49-59
33520283-3	2021	The final positive charge from the aluminium(III) cation is balanced by an NO3 - or a Cl- anion for (1) and (2), respectively.	ALUMINUM ION	35-49	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
32652343-7	2020	Furthermore, addition of Al3+ and Fe3+ decreased peroxidase (POD) activity and inhibited degradation of dichlorvos and malathion.	ALUMINUM ION	25-29	peroxidase 2-like	Cucumis sativus	61-64
32125570-6	2020	Theoretical calculations show the possible structure both of the L-beta-CD adduct and of the coordination mode of Al3+ ion to L. In the presence of beta-CD, the piperazine adopts a distorted conformation.	ALUMINUM ION	114-118	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	148-155
32345545-6	2020	In addition, impaired nucleotide release by Al3+ reduced P2Y1 and adenosine A2A receptors expression in differentiated neurospheres.	ALUMINUM ION	44-48	purinergic receptor P2Y1	Homo sapiens	57-89
32718636-1	2020	In Europe, the use of aluminium(III) compounds, namely AlK(SO4)2 12H2O and later on Al2(SO4)3 18H2O for hardening gelatin sizes was recorded as early as the 16th century.	ALUMINUM ION	22-36	ALK receptor tyrosine kinase	Homo sapiens	55-58
32666573-1	2020	Malate exudation through wheat (Triticum aestivum L) aluminium-activated malate transporter 1 (TaALMT1) confers Al3+ tolerance at low pH, but is also activated by alkaline pH, and is regulated by and facilitates significant transport of gamma-aminobutyric acid (GABA, a zwitterionic buffer).	ALUMINUM ION	112-116	aluminum-activated malate transporter 1	Triticum aestivum	95-102
32330778-5	2020	With the progress of hydrothermal treatment, the impure Al3+ gradually replaced part of the Fe3+ in the alpha-Fe2O3 crystal.	ALUMINUM ION	56-60	l(2)FE3	Drosophila melanogaster	92-95
32330778-6	2020	Specifically, Al3+ was preferentially adsorbed on the (001) facet, hindering the growth of Fe3+ on the [001] direction and thus causing the flattening of the resultant FAO.	ALUMINUM ION	14-18	l(2)FE3	Drosophila melanogaster	91-94
32330778-7	2020	The introduced Al3+ also serves as the disordered defects on the hematite surface, leading to decreased crystal parameters for hematite, the formation of a compact first shell and a reduced periodical symmetry for the central cation Fe3+.	ALUMINUM ION	15-19	l(2)FE3	Drosophila melanogaster	233-236
32146649-2	2020	It served as a fluorescent turn-on chemosensor for selective detection of Hg2+ ion over other common competitive metal ions including Li+, Na+, K+, Ag+, Cu2+, Fe2+, Zn2+, Co2+, Ni2+, Mn2+, Sr2+, Ca2+, Mg2+, Al3+, Cr3+ and Fe3+ ions based on the Hg2+-promoted desulfurization and cyclization reactions.	ALUMINUM ION	207-211	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	74-77
32211624-3	2020	HL1 selectively sensed Zn2+ ions, whereas HL2 detected Al3+ ions.	ALUMINUM ION	55-59	intelectin 2	Homo sapiens	42-45
32355284-2	2020	In maize, ZmMATE1 confers Al tolerance via Al-activated citrate release, whereby citrate forms non-toxic complexes with Al3+ in the rhizosphere.	ALUMINUM ION	120-124	Protein DETOXIFICATION 42	Zea mays	10-17
31343013-3	2019	Based on analysis with native gel electrophoresis, Al3+ plus 8-hydroxyquinoline staining and LC-MS/MS, the proteins with high Al3+ affinity were identified to be carbamoyl-phosphate synthase, adenosylhomocysteinase, heat shock protein 90-alpha, carbonic anhydrase 3, serum albumin and calreticulin.	ALUMINUM ION	126-130	adenosylhomocysteinase	Rattus norvegicus	192-214
32101795-2	2020	The proposed assay has shown an excellent selective fluorescence response toward Cd2+ ions over other ions like Al3+, Pb2+, Zn2+, Co2+, K+, Na+ and Sr2+.	ALUMINUM ION	112-116	CD2 molecule	Homo sapiens	81-84
32144222-7	2019	In summary, the application of 100 mg L-1 Na-bentonite with 20 mg L-1 Al3+ (from BOPAC) and 0.5 mg L-1 anionic polyelectrolyte resulted in the efficient reduction of the turbidity (4-6 NTU), the COD (158 mg L-1) and the extractable oil content (4 mg L-1) with efficiencies of 98%, 59%, and 85%, respectively.	ALUMINUM ION	70-74	immunoglobulin kappa variable 1-16	Homo sapiens	38-41
32144222-7	2019	In summary, the application of 100 mg L-1 Na-bentonite with 20 mg L-1 Al3+ (from BOPAC) and 0.5 mg L-1 anionic polyelectrolyte resulted in the efficient reduction of the turbidity (4-6 NTU), the COD (158 mg L-1) and the extractable oil content (4 mg L-1) with efficiencies of 98%, 59%, and 85%, respectively.	ALUMINUM ION	70-74	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
32144222-7	2019	In summary, the application of 100 mg L-1 Na-bentonite with 20 mg L-1 Al3+ (from BOPAC) and 0.5 mg L-1 anionic polyelectrolyte resulted in the efficient reduction of the turbidity (4-6 NTU), the COD (158 mg L-1) and the extractable oil content (4 mg L-1) with efficiencies of 98%, 59%, and 85%, respectively.	ALUMINUM ION	70-74	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
32144222-7	2019	In summary, the application of 100 mg L-1 Na-bentonite with 20 mg L-1 Al3+ (from BOPAC) and 0.5 mg L-1 anionic polyelectrolyte resulted in the efficient reduction of the turbidity (4-6 NTU), the COD (158 mg L-1) and the extractable oil content (4 mg L-1) with efficiencies of 98%, 59%, and 85%, respectively.	ALUMINUM ION	70-74	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
32144222-7	2019	In summary, the application of 100 mg L-1 Na-bentonite with 20 mg L-1 Al3+ (from BOPAC) and 0.5 mg L-1 anionic polyelectrolyte resulted in the efficient reduction of the turbidity (4-6 NTU), the COD (158 mg L-1) and the extractable oil content (4 mg L-1) with efficiencies of 98%, 59%, and 85%, respectively.	ALUMINUM ION	70-74	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
31203957-7	2019	ALP could hydrolyze PPi into phosphate, destroying the PPi-Al3+ complex and releasing Al3+.	ALUMINUM ION	59-63	alkaline phosphatase, placental	Homo sapiens	0-3
31203957-7	2019	ALP could hydrolyze PPi into phosphate, destroying the PPi-Al3+ complex and releasing Al3+.	ALUMINUM ION	86-90	alkaline phosphatase, placental	Homo sapiens	0-3
31350362-3	2019	vha-a2 vha-a3 mutant plants displayed less Al sensitivity with less Al accumulation in roots compared to wild-type plants when grown under excessive Al3+ Interestingly, in response to Al3+ exposure, plants showed decreased vacuolar H+ pump activity and reduced expression of VHA-a2 and VHA-a3, which were accompanied by increased plasma membrane H+ pump (PM H+-ATPase) activity.	ALUMINUM ION	149-153	vacuolar proton ATPase A2	Arabidopsis thaliana	0-6
31350362-3	2019	vha-a2 vha-a3 mutant plants displayed less Al sensitivity with less Al accumulation in roots compared to wild-type plants when grown under excessive Al3+ Interestingly, in response to Al3+ exposure, plants showed decreased vacuolar H+ pump activity and reduced expression of VHA-a2 and VHA-a3, which were accompanied by increased plasma membrane H+ pump (PM H+-ATPase) activity.	ALUMINUM ION	149-153	vacuolar proton ATPase A3	Arabidopsis thaliana	7-13
31350362-3	2019	vha-a2 vha-a3 mutant plants displayed less Al sensitivity with less Al accumulation in roots compared to wild-type plants when grown under excessive Al3+ Interestingly, in response to Al3+ exposure, plants showed decreased vacuolar H+ pump activity and reduced expression of VHA-a2 and VHA-a3, which were accompanied by increased plasma membrane H+ pump (PM H+-ATPase) activity.	ALUMINUM ION	184-188	vacuolar proton ATPase A2	Arabidopsis thaliana	0-6
31350362-3	2019	vha-a2 vha-a3 mutant plants displayed less Al sensitivity with less Al accumulation in roots compared to wild-type plants when grown under excessive Al3+ Interestingly, in response to Al3+ exposure, plants showed decreased vacuolar H+ pump activity and reduced expression of VHA-a2 and VHA-a3, which were accompanied by increased plasma membrane H+ pump (PM H+-ATPase) activity.	ALUMINUM ION	184-188	vacuolar proton ATPase A3	Arabidopsis thaliana	7-13
31350362-3	2019	vha-a2 vha-a3 mutant plants displayed less Al sensitivity with less Al accumulation in roots compared to wild-type plants when grown under excessive Al3+ Interestingly, in response to Al3+ exposure, plants showed decreased vacuolar H+ pump activity and reduced expression of VHA-a2 and VHA-a3, which were accompanied by increased plasma membrane H+ pump (PM H+-ATPase) activity.	ALUMINUM ION	184-188	vacuolar proton ATPase A2	Arabidopsis thaliana	275-281
31350362-3	2019	vha-a2 vha-a3 mutant plants displayed less Al sensitivity with less Al accumulation in roots compared to wild-type plants when grown under excessive Al3+ Interestingly, in response to Al3+ exposure, plants showed decreased vacuolar H+ pump activity and reduced expression of VHA-a2 and VHA-a3, which were accompanied by increased plasma membrane H+ pump (PM H+-ATPase) activity.	ALUMINUM ION	184-188	vacuolar proton ATPase A3	Arabidopsis thaliana	286-292
31328918-2	2019	When they are reacted with Al3+, these complexes exhibit dramatic enhancements in emission intensity (775-fold for Ir1 and 51.0-fold for Ir2) and distinct orange to green changes in emission color.	ALUMINUM ION	27-31	nischarin	Homo sapiens	115-118
31328918-3	2019	The reactions of Ir1 and Ir2 with Al3+ were found to barely be affected by nearly all common metal ions.	ALUMINUM ION	34-38	nischarin	Homo sapiens	17-20
31048249-2	2019	Here, a turn-on Schiff base fluorescence probe STH based on excited state intramolecular proton transfer and photoelectron transfer processes for Al3+ detection with fast response rate (within minutes), low detection limit (4.26x10-8M), high selectivity and reasonable pH application range (5.0-8.0) was developed.	ALUMINUM ION	146-150	saitohin	Homo sapiens	47-50
31048249-3	2019	Fluorescence titration experiments show that probe STH has an excellent linear relationship (R2=0.9694) with Al3+ concentration and could be applied to quantitatively recognize Al3+ in real-water samples.	ALUMINUM ION	109-113	saitohin	Homo sapiens	51-54
31048249-3	2019	Fluorescence titration experiments show that probe STH has an excellent linear relationship (R2=0.9694) with Al3+ concentration and could be applied to quantitatively recognize Al3+ in real-water samples.	ALUMINUM ION	177-181	saitohin	Homo sapiens	51-54
31048249-4	2019	Based on Job"s plot and in situ mass spectra, two STH molecules will complex with Al3+ to form 2:1 complexation with oxygen atoms of hydroxyl and carbonyl groups and nitrogen atom of CN bond participating in coordination.	ALUMINUM ION	82-86	saitohin	Homo sapiens	50-53
31054496-5	2019	The higher binding constants 6.7 x 103 M-1 and 3.8 x 103 M-1 for Al3+ and Cr3+, respectively and lower detection limits 1 x 10-6 M and 2 x 10-6 M for Al3+ and Cr3+, respectively in a buffered solution with high reversible nature describes the potential of L as an effective tool for detecting Al3+ and Cr3+ in a biological system with higher intracellular resolution.	ALUMINUM ION	65-69	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	159-162
31054496-5	2019	The higher binding constants 6.7 x 103 M-1 and 3.8 x 103 M-1 for Al3+ and Cr3+, respectively and lower detection limits 1 x 10-6 M and 2 x 10-6 M for Al3+ and Cr3+, respectively in a buffered solution with high reversible nature describes the potential of L as an effective tool for detecting Al3+ and Cr3+ in a biological system with higher intracellular resolution.	ALUMINUM ION	65-69	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	159-162
31054496-5	2019	The higher binding constants 6.7 x 103 M-1 and 3.8 x 103 M-1 for Al3+ and Cr3+, respectively and lower detection limits 1 x 10-6 M and 2 x 10-6 M for Al3+ and Cr3+, respectively in a buffered solution with high reversible nature describes the potential of L as an effective tool for detecting Al3+ and Cr3+ in a biological system with higher intracellular resolution.	ALUMINUM ION	150-154	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	74-77
31054496-5	2019	The higher binding constants 6.7 x 103 M-1 and 3.8 x 103 M-1 for Al3+ and Cr3+, respectively and lower detection limits 1 x 10-6 M and 2 x 10-6 M for Al3+ and Cr3+, respectively in a buffered solution with high reversible nature describes the potential of L as an effective tool for detecting Al3+ and Cr3+ in a biological system with higher intracellular resolution.	ALUMINUM ION	150-154	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	74-77
31363819-8	2019	Flow cytometry and immunocytochemistry analysis showed that Al3+ promoted a decrease in immature neuronal marker beta3-tubulin expression and an increase in co-expression of the NPC marker nestin and glial fibrillary acidic protein.	ALUMINUM ION	60-64	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	113-118
31343013-3	2019	Based on analysis with native gel electrophoresis, Al3+ plus 8-hydroxyquinoline staining and LC-MS/MS, the proteins with high Al3+ affinity were identified to be carbamoyl-phosphate synthase, adenosylhomocysteinase, heat shock protein 90-alpha, carbonic anhydrase 3, serum albumin and calreticulin.	ALUMINUM ION	126-130	carbonic anhydrase 3	Rattus norvegicus	245-265
31343013-3	2019	Based on analysis with native gel electrophoresis, Al3+ plus 8-hydroxyquinoline staining and LC-MS/MS, the proteins with high Al3+ affinity were identified to be carbamoyl-phosphate synthase, adenosylhomocysteinase, heat shock protein 90-alpha, carbonic anhydrase 3, serum albumin and calreticulin.	ALUMINUM ION	126-130	albumin	Rattus norvegicus	267-280
31343013-3	2019	Based on analysis with native gel electrophoresis, Al3+ plus 8-hydroxyquinoline staining and LC-MS/MS, the proteins with high Al3+ affinity were identified to be carbamoyl-phosphate synthase, adenosylhomocysteinase, heat shock protein 90-alpha, carbonic anhydrase 3, serum albumin and calreticulin.	ALUMINUM ION	126-130	calreticulin	Rattus norvegicus	285-297
30901706-3	2019	This report successfully designed a new polysiloxane-based polymer fluorescent probe (RB-1) for the first time as a "turn-on" fluorescent probe response to Al3+ ion with highly sensitive and selectivity.	ALUMINUM ION	156-160	retinoblastoma 1	Danio rerio	86-90
30952027-3	2019	Further, the high selectivity of receptor 1 towards Hg2+ ions in the presence of various other interfering metal ions like Ni2+, Zn2+, Mn2+, Co2+, Cu2+, Cr3+, Fe3+, Al3+, Ag+, Fe2+, Cd2+, Mg2+, Pb2+, Ca2+, Na+, K+ was confirmed by UV-Vis and fluorescence methods.	ALUMINUM ION	165-169	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	52-55
30916671-0	2019	Competition between Al3+ and Fe3+ binding to human transferrin and toxicological implications: structural investigations using ultra-high resolution ESI MS and CD spectroscopy.	ALUMINUM ION	20-24	transferrin	Homo sapiens	51-62
30240714-8	2019	Finally, it was found that the Pb(II) sorption on AlgS is significantly affected by the presence of cationic (Na+, Mg2+ and Al3+) and anionic (Cl-, NO3-) co-ions.	ALUMINUM ION	124-128	submaxillary gland androgen regulated protein 3B	Homo sapiens	31-37
30960557-0	2019	A Highly Selective Turn-on and Reversible Fluorescent Chemosensor for Al3+ Detection Based on Novel Salicylidene Schiff Base-Terminated PEG in Pure Aqueous Solution.	ALUMINUM ION	70-74	progestagen associated endometrial protein	Homo sapiens	136-139
30772605-2	2019	The amide derivatives 5a-f showed moderate potency against GSK-3beta with weak Cu2+, Zn2+ and Al3+ chelating ability.	ALUMINUM ION	94-98	glycogen synthase kinase 3 alpha	Homo sapiens	59-68
30562703-3	2019	The probe showed high selectivity and sensitivity to target ions in the process of relay recognition, and the corresponding detection limit could be as low as 0.014 muM (Al3+) and 0.03 muM (F-).	ALUMINUM ION	170-174	latexin	Homo sapiens	165-168
30562703-3	2019	The probe showed high selectivity and sensitivity to target ions in the process of relay recognition, and the corresponding detection limit could be as low as 0.014 muM (Al3+) and 0.03 muM (F-).	ALUMINUM ION	170-174	latexin	Homo sapiens	185-188
30462136-6	2019	LODs for Fe3+, Al3+ and Cr3+ were determined by 3sigma methods and found to be 1.28, 1.34 and 2.28 muM, respectively.	ALUMINUM ION	15-19	latexin	Homo sapiens	99-102
30219854-9	2019	Despite TaMATE1B being less effective than TaALMT1 at conferring Al3+ resistance based on root growth, the gene promoted grain yield to a similar level to TaALMT1 when the plants were grown in acid soil.	ALUMINUM ION	65-69	aluminum-activated malate transporter 1	Triticum aestivum	43-50
30048727-2	2018	In this work, the interactions between MT2-MMP and common trivalent metal ions, including aluminum (Al3+) and ferrum (Fe3+) ions, were investigated.	ALUMINUM ION	100-104	matrix metallopeptidase 15	Homo sapiens	39-46
30048727-3	2018	Enzymatic detection revealed that Al3+ and Fe3+ strongly inhibited the MT2-MMP.	ALUMINUM ION	34-38	matrix metallopeptidase 15	Homo sapiens	71-78
30048727-6	2018	The potential inhibitory effect of Al3+ on MT2-MMP was further examined in an MT2-MMP-overexpressed cell line, HT1080, by using flow cytometry.	ALUMINUM ION	35-39	matrix metallopeptidase 15	Homo sapiens	43-50
30230322-3	2018	In comparison, the pyrite oxidation rate at circumneutral pH (7.4 +- 0.4) decreased with increasing added Al3+ with  98% reduction in long-term (282 days) dissolution rates in the presence of 20 mg L-1 Al3+.	ALUMINUM ION	106-110	L1 cell adhesion molecule	Homo sapiens	198-201
30230322-3	2018	In comparison, the pyrite oxidation rate at circumneutral pH (7.4 +- 0.4) decreased with increasing added Al3+ with  98% reduction in long-term (282 days) dissolution rates in the presence of 20 mg L-1 Al3+.	ALUMINUM ION	202-206	L1 cell adhesion molecule	Homo sapiens	198-201
30230322-4	2018	Al3+ was added to the solution and allowed to equilibrate prior to pyrite addition (2 g L-1).	ALUMINUM ION	0-4	L1 cell adhesion molecule	Homo sapiens	88-91
30735295-4	2019	Experimental and theoretical simulations demonstrate that Al3+ ions substituting Co2+ Td and Co3+ Oh active sites, especially Al3+ ions occupying the Co2+ Td sites, optimizes the adsorption, activation, and desorption features of intermediate species during oxygen evolution reaction (OER) processes.	ALUMINUM ION	58-62	complement C2	Homo sapiens	81-84
30735295-4	2019	Experimental and theoretical simulations demonstrate that Al3+ ions substituting Co2+ Td and Co3+ Oh active sites, especially Al3+ ions occupying the Co2+ Td sites, optimizes the adsorption, activation, and desorption features of intermediate species during oxygen evolution reaction (OER) processes.	ALUMINUM ION	58-62	complement C2	Homo sapiens	150-153
30735295-4	2019	Experimental and theoretical simulations demonstrate that Al3+ ions substituting Co2+ Td and Co3+ Oh active sites, especially Al3+ ions occupying the Co2+ Td sites, optimizes the adsorption, activation, and desorption features of intermediate species during oxygen evolution reaction (OER) processes.	ALUMINUM ION	126-130	complement C2	Homo sapiens	81-84
30735295-4	2019	Experimental and theoretical simulations demonstrate that Al3+ ions substituting Co2+ Td and Co3+ Oh active sites, especially Al3+ ions occupying the Co2+ Td sites, optimizes the adsorption, activation, and desorption features of intermediate species during oxygen evolution reaction (OER) processes.	ALUMINUM ION	126-130	complement C2	Homo sapiens	150-153
30219854-9	2019	Despite TaMATE1B being less effective than TaALMT1 at conferring Al3+ resistance based on root growth, the gene promoted grain yield to a similar level to TaALMT1 when the plants were grown in acid soil.	ALUMINUM ION	65-69	LOC101664696	Triticum aestivum	8-16
30781820-5	2019	Bi3+ and Al3+ inhibition on the Pt/PPD/GOx biosensor response is for the first time reported.	ALUMINUM ION	9-13	hydroxyacid oxidase 1	Homo sapiens	39-42
30448750-6	2019	Al3+ and their hydroxide colloids have a significant effect on DBP formation.	ALUMINUM ION	0-4	D-box binding PAR bZIP transcription factor	Homo sapiens	63-66
30615410-2	2019	Recently, colloidal chemistry methods have enabled the design of core-shell nanocrystals of Li1+ xMn2- xO4, an important battery cathode, with passivating shells rich in Al3+ through a colloidal synthetic route.	ALUMINUM ION	170-174	transglutaminase 1	Homo sapiens	92-95
30615410-7	2019	Li1+ xMn2- xO4 nanocrystals with Al3+-rich shells of different thicknesses were synthesized.	ALUMINUM ION	33-37	transglutaminase 1	Homo sapiens	0-3
30302553-1	2019	KEY MESSAGE: The structural differences of MYB14 promoter in two grapevine genotypes affect the expression of MYB14 and stilbene synthesis in response to Al3+ and UV-C radiation.	ALUMINUM ION	154-158	R2R3 Myb14 transcription factor	Vitis vinifera	43-48
30302553-1	2019	KEY MESSAGE: The structural differences of MYB14 promoter in two grapevine genotypes affect the expression of MYB14 and stilbene synthesis in response to Al3+ and UV-C radiation.	ALUMINUM ION	154-158	R2R3 Myb14 transcription factor	Vitis vinifera	110-115
30302553-7	2019	Significant differences in the structure and activity of the promoter of MYB14, but not MYB15 were identified between the two genotypes, following heterologous expression in Nicotiana benthamiana system and treatments with Al3+ and UV-C. Hydrogen peroxide (H2O2) was detected in Concord soon after the stress treatments, but after diphenyleneiodonium chloride pre-treatment, the expressing level of VlMYB14, the promoter activity of VlMYB14 and the accumulation of stilbenes was significantly reduced.	ALUMINUM ION	223-227	R2R3 Myb14 transcription factor	Vitis vinifera	73-78
30262061-3	2019	Al3+ and Fe3+ were found at markedly high levels on and around Abeta protofibrils comparing with the normal part of brain.	ALUMINUM ION	0-4	amyloid beta precursor protein	Homo sapiens	63-68
30218965-6	2018	Activities of antioxidant enzymes, i.e., superoxide dismustase, catalase, guaiacol peroxidase in root and shoot were enhanced by Al3+.	ALUMINUM ION	129-133	catalase	Vigna radiata	64-72
30558162-2	2018	In this respect, we studied the complexation of CIT and ochratoxin A (OTA) with Al3+ in methanol using absorption and fluorescence spectroscopy.	ALUMINUM ION	80-84	citron rho-interacting serine/threonine kinase	Homo sapiens	48-51
30558162-4	2018	CIT and OTA showed distinct changes in their absorption and fluorescence properties upon Al3+-coordination, and the fluorescence of CIT was considerably enhanced.	ALUMINUM ION	89-93	citron rho-interacting serine/threonine kinase	Homo sapiens	0-3
30558162-5	2018	Analysis of the photometrically assessed titration of CIT and OTA with Al3+ using the Job plot method revealed 1:2 and 1:1 stoichiometries for the Al3+ complexes of CIT (Al:CIT) and OTA (Al:OTA), respectively.	ALUMINUM ION	71-75	citron rho-interacting serine/threonine kinase	Homo sapiens	54-57
30558162-5	2018	Analysis of the photometrically assessed titration of CIT and OTA with Al3+ using the Job plot method revealed 1:2 and 1:1 stoichiometries for the Al3+ complexes of CIT (Al:CIT) and OTA (Al:OTA), respectively.	ALUMINUM ION	71-75	citron rho-interacting serine/threonine kinase	Homo sapiens	165-168
30558162-5	2018	Analysis of the photometrically assessed titration of CIT and OTA with Al3+ using the Job plot method revealed 1:2 and 1:1 stoichiometries for the Al3+ complexes of CIT (Al:CIT) and OTA (Al:OTA), respectively.	ALUMINUM ION	71-75	citron rho-interacting serine/threonine kinase	Homo sapiens	165-168
30558162-5	2018	Analysis of the photometrically assessed titration of CIT and OTA with Al3+ using the Job plot method revealed 1:2 and 1:1 stoichiometries for the Al3+ complexes of CIT (Al:CIT) and OTA (Al:OTA), respectively.	ALUMINUM ION	147-151	citron rho-interacting serine/threonine kinase	Homo sapiens	54-57
30558162-5	2018	Analysis of the photometrically assessed titration of CIT and OTA with Al3+ using the Job plot method revealed 1:2 and 1:1 stoichiometries for the Al3+ complexes of CIT (Al:CIT) and OTA (Al:OTA), respectively.	ALUMINUM ION	147-151	citron rho-interacting serine/threonine kinase	Homo sapiens	165-168
30558162-5	2018	Analysis of the photometrically assessed titration of CIT and OTA with Al3+ using the Job plot method revealed 1:2 and 1:1 stoichiometries for the Al3+ complexes of CIT (Al:CIT) and OTA (Al:OTA), respectively.	ALUMINUM ION	147-151	citron rho-interacting serine/threonine kinase	Homo sapiens	165-168
30558162-6	2018	In the case of CIT, only one beta-diketone moiety participates in Al3+ coordination.	ALUMINUM ION	66-70	citron rho-interacting serine/threonine kinase	Homo sapiens	15-18
28718959-7	2018	The binding constant and the detection limit of L for Al3+ were calculated to 2.6 x 104  M-1 and 0.34 muM, respectively.	ALUMINUM ION	54-58	latexin	Homo sapiens	102-105
29604444-1	2018	The adsorption of metal ions (K+, Na+, Ca2+, Cu2+, Al3+, Cr3+) on the (1 0 0) surface of potassium dihydrogen phosphate (KDP) has been studied using density functional theory (DFT).	ALUMINUM ION	51-55	WNK lysine deficient protein kinase 1	Homo sapiens	121-124
30070481-2	2018	However, among the possible extra-framework aluminum (EFAL) species in dealuminated zeolites such as Al3+, Al(OH)2+, Al(OH)2+, AlO+, AlOOH, and Al(OH)3, the presence of tri-coordinated EFAL-Al3+ species, which exhibit large quadrupolar effect due to the lack of hydrogen-bonding species, was normally undetectable by conventional one- and two-dimensional 1H and/or 27Al solid-state nuclear magnetic resonance (SSNMR) techniques.	ALUMINUM ION	190-194	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	169-172
29458585-2	2018	Rh6G-Cin displayed high selectivity towards Zn2+ from various metal ions, including Ca2+, Ag+, Cd2+, Co2+, Cu2+, Al3+, Zn2+, Cr3+, Ba2+, Fe2+, Fe3+, Gd3+, Hg2+, Mg2+, Mn2+, Nd3+, Pb2+, Sr2+ and Ni2+, and the resultant complex is [Rh6G-Cin-Zn2+].	ALUMINUM ION	113-117	pyridoxal phosphatase	Homo sapiens	5-8
29932319-3	2018	A weak interaction between PPPNa and serum albumin was found, which caused no interference, but enhanced fluorescence response of PPPNa to Al3+ and improved detection sensitivity.	ALUMINUM ION	139-143	albumin	Homo sapiens	37-50
29932319-4	2018	The limit of detection was determined to be 1.50 mumol/L Al3+ in phosphate-buffered saline solution containing 33 mug/mL bovine serum albumin (BSA) and decreased to 0.98 mumol/L as BSA concentration increased to 100 mug/mL.	ALUMINUM ION	57-61	albumin	Homo sapiens	128-141
29648807-0	2018	Density of Grafted Chains in Thioglycerol-Capped CdS Quantum Dots Determines Their Interaction with Aluminum(III) in Water.	ALUMINUM ION	100-113	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
29796828-1	2018	A new multifunctional chemosensor 1, (E)-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)-1H-benzo[de]isoquinoline-1,3(2H)-dione, based on naphtalimide and naphthaldehyde was developed, which showed the fluorescence responses to trivalent metal ions (Ga3+, Al3+ and Cr3+).	ALUMINUM ION	255-259	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	264-267
29654524-5	2018	This receptor exhibit more selectivity and sensitivity towards Cr3+ than other divalent and trivalent cations like Mn2+, Zn2+, Co2+, Ni2+, Cd2+, Cu2+, Hg2+, Fe3+, and Al3+ ions.	ALUMINUM ION	167-171	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	63-66
32254185-6	2018	The fluorogenic probe in the film showed a sensitive, selective response to Al3+ with a detection limit of 1.5 muM.	ALUMINUM ION	76-80	latexin	Homo sapiens	111-114
30090569-3	2018	Based on affinity analyses with Al and LC-LTQ-MS, we have found that serum albumin, brain CK-B and 14-3-3zeta protein have a high affinity for Al3+, and albumin has a much stronger affinity for Al than transferrin.	ALUMINUM ION	143-147	creatine kinase B	Homo sapiens	90-109
29327751-0	2018	A novel covalent post-synthetically modified MOF hybrid as a sensitive and selective fluorescent probe for Al3+ detection in aqueous media.	ALUMINUM ION	107-111	lysine acetyltransferase 8	Homo sapiens	45-48
29768813-2	2018	Doping the cathodes with Al3+ and Cl- ions enhanced electrochemical performance at room temperature and at a high working temperature of 55  C. The as-synthesized optimal composition was Li1.2Ni0.37Al0.03Mn0.6O2.17Cl0.03.	ALUMINUM ION	25-29	transglutaminase 1	Homo sapiens	187-190
28787623-6	2018	The association constants (Ka) for Cr3+ and Al3+ were calculated and found to be 8.33x104M-1 and 5.44x104M-1, respectively.	ALUMINUM ION	44-48	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	35-38
29265811-3	2018	reveals that Al3+ ions diffuse into the spinel to form a layered Li(Alx,Mny)O2 structure in the outmost surface where Al3+ concentration is the highest.	ALUMINUM ION	13-17	hematopoietic SH2 domain containing	Homo sapiens	68-71
29265811-3	2018	reveals that Al3+ ions diffuse into the spinel to form a layered Li(Alx,Mny)O2 structure in the outmost surface where Al3+ concentration is the highest.	ALUMINUM ION	118-122	hematopoietic SH2 domain containing	Homo sapiens	68-71
29100758-9	2017	The enzyme was inhibited by Al3+, Cd2+ and Mg2+, whereas Ca2+, Co2+ and Ni2+ stimulated the catalase activity.	ALUMINUM ION	28-32	catalase	Camelus dromedarius	92-100
30090569-3	2018	Based on affinity analyses with Al and LC-LTQ-MS, we have found that serum albumin, brain CK-B and 14-3-3zeta protein have a high affinity for Al3+, and albumin has a much stronger affinity for Al than transferrin.	ALUMINUM ION	143-147	transferrin	Homo sapiens	202-213
28937661-4	2017	The calibration curve determines the detection limit (LOD) for Al3+ about 20 ppb (0.067 muM) is presented using both decrease and increase in absorbance at 530 and 700 nm, respectively.	ALUMINUM ION	63-67	latexin	Homo sapiens	88-91
28806680-1	2017	The speciation of Al3+ in aqueous solutions containing organic and inorganic ligands important from a biological (citrate (Cit3-), gluconate (Gluc-), lactate (Lac-), silicate (H2SiO42-), carbonate (CO32-), fluoride (F-)) and industrial (Gantrez ; polymethyl-vinyl-ether-co-maleic acids; GTZ S95 and GTZ AN169) point of view is reported.	ALUMINUM ION	18-22	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	142-146
28806680-2	2017	The stability constants of Al3+/Lz- complexes (Lz- = ligand with z- charge) were determined by potentiometry at T = 298.15 K and 0.10 <= I/M <= 1.00 in NaCl(aq) (in NaNO3(aq) only for Al3+/GTZ S95 and Al3+/Gluc- acid systems).	ALUMINUM ION	27-31	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	212-216
28806680-8	2017	The sequestering ability of the ligands towards Al3+ was investigated determining the pL0.5 parameter at different experimental conditions, finding the following trend: Cit3- >> Gluc- > GTZ S954- > GTZ AN1694- > Lac- for the organic ligands, and pL0.5: F- >> CO32- > H2SiO42- for the inorganic ones.	ALUMINUM ION	48-52	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	184-188
28913653-2	2017	There is evidence that Al3+ exposure interferes with NO3- uptake.	ALUMINUM ION	23-27	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
28913653-6	2017	When exposed to added Al3+, the proportion of inorganic N acquired as NO3- dropped 14% across species, but we did not detect a reduction in overall N uptake, nor did tree species differ in this response.	ALUMINUM ION	22-26	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
28913653-8	2017	Thus, increased levels of soil Al3+ under acidic deposition cause a reduction in uptake of NO3- by mature trees.	ALUMINUM ION	31-35	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
28913653-9	2017	When our 15N uptake results were applied to the watershed acidification experiment, they suggest that increased Al3+ exposure could reduce tree uptake of NO3- by 7.73 kg N ha-1 year-1, and thus increase watershed NO3- discharge.	ALUMINUM ION	112-116	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
28913653-9	2017	When our 15N uptake results were applied to the watershed acidification experiment, they suggest that increased Al3+ exposure could reduce tree uptake of NO3- by 7.73 kg N ha-1 year-1, and thus increase watershed NO3- discharge.	ALUMINUM ION	112-116	NBL1, DAN family BMP antagonist	Homo sapiens	213-216
28937661-5	2017	This value is considerably lower than the higher limit allowed for Al3+ in drinking water by the world health organization (WHO) (7.41 muM), representing enough sensitivity to protect water quality.	ALUMINUM ION	67-71	latexin	Homo sapiens	135-138
28745369-4	2017	The administration of CGA (50 muM) increased cell viability by 37.5%, decreased the levels of Al3+ by 26.0%, together with significantly weakening the oxidative damage compared with Al treatment alone.	ALUMINUM ION	94-98	latexin	Homo sapiens	30-33
28370437-1	2017	A detailed mechanistic investigation identified the stepwise nature of the 1,3-aryl shift, which enables our recently disclosed Al3+ -catalyzed insertion of unactivated alkynes into the sp2 -sp3 C-C bond of benzyl alcohols.	ALUMINUM ION	128-132	Sp2 transcription factor	Homo sapiens	186-189
28370437-1	2017	A detailed mechanistic investigation identified the stepwise nature of the 1,3-aryl shift, which enables our recently disclosed Al3+ -catalyzed insertion of unactivated alkynes into the sp2 -sp3 C-C bond of benzyl alcohols.	ALUMINUM ION	128-132	Sp3 transcription factor	Homo sapiens	191-194
28758753-0	2017	The Design of Dual-Emissive Composite Material [Zn2(HL)3]+@MOF-5 as Self-Calibrating Luminescent Sensors of Al3+ Ions and Monoethanolamine.	ALUMINUM ION	108-112	lysine acetyltransferase 8	Homo sapiens	59-62
28758753-5	2017	Furthermore, by combining characteristics of MOF-5 and the guest chromophore, the composite material is highly selectively sensitive toward Al3+ and monoethanolamine, which makes [Zn2(HL)3]+@MOF-5 a potential self-calibrated fluorescence sensor.	ALUMINUM ION	140-144	lysine acetyltransferase 8	Homo sapiens	45-48
28758753-5	2017	Furthermore, by combining characteristics of MOF-5 and the guest chromophore, the composite material is highly selectively sensitive toward Al3+ and monoethanolamine, which makes [Zn2(HL)3]+@MOF-5 a potential self-calibrated fluorescence sensor.	ALUMINUM ION	140-144	lysine acetyltransferase 8	Homo sapiens	191-194
28737899-5	2017	Moreover, pink 1 Al3+ and 2 Al3+ ensembles selectively sensed F- ions over other halides through a discharge of color.	ALUMINUM ION	17-21	PTEN induced kinase 1	Homo sapiens	10-16
28347970-6	2017	The morphology of precipitates was transformed from prismatic crystals to stacked layered crystals, which confirmed that Mg2+ competes with Ca2+ for Al3+ to form HT compound.	ALUMINUM ION	149-153	mucin 7, secreted	Homo sapiens	121-124
28475492-5	2017	The detection limit of NQ for Al3+ detection was 1.98 muM, which is lower than the level (7.4 muM) in drinking water defined by the World Health Organization.	ALUMINUM ION	30-34	latexin	Homo sapiens	54-57
28475492-5	2017	The detection limit of NQ for Al3+ detection was 1.98 muM, which is lower than the level (7.4 muM) in drinking water defined by the World Health Organization.	ALUMINUM ION	30-34	latexin	Homo sapiens	94-97
27858300-9	2017	The concentration dependent studies suggest that 4-HMP-PDI can detect up to 36.52 ppb of Fe3+ and 43.12 ppb of Al3+ colorimetrically.	ALUMINUM ION	111-115	inner membrane mitochondrial protein	Homo sapiens	51-54
28340396-2	2017	The chemosensor 1 is developed as a dual chemosensor for detection of Hg2+ and Al3+ ions in CH3OH, which exhibited a color change from light yellow to dark yellow with Hg2+ ions, enabling 1 a suitable "bare eye" indicator for Hg2+ ions.	ALUMINUM ION	79-83	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	168-171
28340396-2	2017	The chemosensor 1 is developed as a dual chemosensor for detection of Hg2+ and Al3+ ions in CH3OH, which exhibited a color change from light yellow to dark yellow with Hg2+ ions, enabling 1 a suitable "bare eye" indicator for Hg2+ ions.	ALUMINUM ION	79-83	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	168-171
28259076-3	2017	The results indicate that, in the presence of either Mg2+ or Ca2+, an increasing depression of the binding of Al3+-DOM could be observed in the differential spectra of DOM with the increasing of Mg2+ or Ca2+ at a level of 10, 100 and 1000 muM, with the observation being more significant at higher pH from 6.5 to 8.5.	ALUMINUM ION	110-114	latexin	Homo sapiens	239-242
28368059-7	2017	In the presence of commonly coexisting metal ions, such as Hg2+, Fe3+, Cu2+ and Al3+, BRI undergoes either catalytic Schiff base hydrolysis or it is unaffected by its affinity to the metal ions.	ALUMINUM ION	80-84	integral membrane protein 2B	Homo sapiens	86-89
28372359-7	2017	Our method illustrates a novel detection strategy mediated by complexation reaction between Al3+ and AgNCs avoiding the involvement of copper cations in the detection, and this developed assay performed well in detection of PPase level in fresh rat serum.	ALUMINUM ION	92-96	inorganic pyrophosphatase 1	Homo sapiens	224-229
28372359-8	2017	This work confirms unique aggregation-induced emission enhancement property of glutathione-capped AgNCs, constructs multiple luminescence switches based on its multistimuli responsive behaviors, and demonstrates an example of Al3+-mediated detection strategy for PPase assay.	ALUMINUM ION	226-230	inorganic pyrophosphatase 1	Homo sapiens	263-268
28110683-3	2017	By contrast, probes 2 and 3 possessing 1,8-naphthalimide and pyrene fluorophores, respectively, exhibited selective fluorescent "OFF-ON" behaviors as a result of Ga3+/Al3+ binding among the diverse metal ions, suggesting the importance of fluorophore electronic character with regard to metal ion sensing.	ALUMINUM ION	167-171	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	162-165
28439024-3	2017	Mutations in NIP1;2 lead to hyperaccumulation of toxic Al3+ in the root cell wall, inhibition of root-to-shoot Al translocation, and a significant reduction in Al tolerance.	ALUMINUM ION	55-59	NOD26-like intrinsic protein 1;2	Arabidopsis thaliana	13-19
28289995-4	2017	Compared with the free P-1, the fluorescence intensity of P-1 shows a significant fluorescence enhancement in the presence of Al3+ without any significant interference from other cations and anions.	ALUMINUM ION	126-130	crystallin gamma F, pseudogene	Homo sapiens	23-26
28289995-4	2017	Compared with the free P-1, the fluorescence intensity of P-1 shows a significant fluorescence enhancement in the presence of Al3+ without any significant interference from other cations and anions.	ALUMINUM ION	126-130	crystallin gamma F, pseudogene	Homo sapiens	58-61
28289995-5	2017	In addition, from the UV-vis titration, fluorescence titration,Job"s plot and 1H NMR spectra analysis, we could primarily confirm that three important coordinative sites of P-1 for Al3+ were from imine nitrogen and tertiary amine nitrogen and formed a 1:1 complex.	ALUMINUM ION	181-185	crystallin gamma F, pseudogene	Homo sapiens	173-176
28289995-6	2017	The fluorescence intensity for the (P-1) showed a good linearity with the concentration of Al3+ in the range of 3.0-10.0 muM, with a detection limit of 8.65 x 10-8 M and a binding constant (Kb) of 4.95 x 104 M-1.	ALUMINUM ION	91-95	crystallin gamma F, pseudogene	Homo sapiens	36-39
28289995-7	2017	It is worthy of note that the probe P-1 was successfully applied in detection of Al3+ in Yellow River and tap water samples.	ALUMINUM ION	81-85	crystallin gamma F, pseudogene	Homo sapiens	36-39
28338927-2	2017	In this work, the effect of Al3+ on the aggregation of hIAPP (11-28) was studied by several different experimental approaches.	ALUMINUM ION	28-32	islet amyloid polypeptide	Homo sapiens	55-60
28338927-3	2017	Atomic force microscopy measurements showed that Al3+ could remarkably inhibit hIAPP(11-28) fibrillogenesis, while Zn2+ had a slight promotion effect on peptide aggregation, which was also confirmed by Thioflavin T fluorescence observation.	ALUMINUM ION	49-53	islet amyloid polypeptide	Homo sapiens	79-84
28194465-4	2017	The deletion of CKA2, the yeast orthologue of mammalian CK2alpha", leads to a pronounced resistant phenotype against Zn2+ and Al3+, whilst the deletion of CKB1 or CKB2 results in tolerance to Cr6+ and As3+.	ALUMINUM ION	126-130	casein kinase 2 catalytic subunit CKA2	Saccharomyces cerevisiae S288C	16-20
28194465-4	2017	The deletion of CKA2, the yeast orthologue of mammalian CK2alpha", leads to a pronounced resistant phenotype against Zn2+ and Al3+, whilst the deletion of CKB1 or CKB2 results in tolerance to Cr6+ and As3+.	ALUMINUM ION	126-130	casein kinase 2 alpha 2	Homo sapiens	56-64
28194465-7	2017	Two contrasting findings were obtained for the CKA2 deletion mutant (cka2Delta) against Al3+ or Zn2+.	ALUMINUM ION	88-92	casein kinase 2 catalytic subunit CKA2	Saccharomyces cerevisiae S288C	47-51
28194465-8	2017	Upon exposure to Al3+, cka2Delta had markedly lower Al3+ content than the wild type and other CK2 mutants, congruous to the resistant phenotype of cka2Delta against Al3+, indicating that CKA2 is responsible for Al3+ uptake.	ALUMINUM ION	17-21	casein kinase 2 catalytic subunit CKA2	Saccharomyces cerevisiae S288C	187-191
27865135-3	2017	The fluorescence intensity of PLP at 433nm was also blue-shifted and enhanced at 395nm upon addition of Al3+.	ALUMINUM ION	104-108	pyridoxal phosphatase	Homo sapiens	30-33
27858300-9	2017	The concentration dependent studies suggest that 4-HMP-PDI can detect up to 36.52 ppb of Fe3+ and 43.12 ppb of Al3+ colorimetrically.	ALUMINUM ION	111-115	prolyl 4-hydroxylase subunit beta	Homo sapiens	55-58
27451659-3	2016	The results showed that the blue shift occurred after the substitution of Ga3+ and In3+ for Al3+ in matrix, and the intensity of emission spectrum was affected by the concentration of Ga3+ and In3+.	ALUMINUM ION	92-96	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	74-77
27865135-4	2017	When the PLP was functionalized over AuNPs surface, the wine red colour of PLP-AuNPs was turned to purplish-blue and the SPR band at ~525nm was red-shifted upon addition of Al3+, Cd2+ and Pb2+ due to the complexation-induced aggregation of nanoparticles.	ALUMINUM ION	173-177	pyridoxal phosphatase	Homo sapiens	9-12
27865135-4	2017	When the PLP was functionalized over AuNPs surface, the wine red colour of PLP-AuNPs was turned to purplish-blue and the SPR band at ~525nm was red-shifted upon addition of Al3+, Cd2+ and Pb2+ due to the complexation-induced aggregation of nanoparticles.	ALUMINUM ION	173-177	pyridoxal phosphatase	Homo sapiens	75-78
27865135-4	2017	When the PLP was functionalized over AuNPs surface, the wine red colour of PLP-AuNPs was turned to purplish-blue and the SPR band at ~525nm was red-shifted upon addition of Al3+, Cd2+ and Pb2+ due to the complexation-induced aggregation of nanoparticles.	ALUMINUM ION	173-177	sepiapterin reductase	Homo sapiens	121-124
27886645-4	2017	Potential applicability of QP for Al3+ detection in tap and lake water samples were also examined by "proof-of-concept" experiments.	ALUMINUM ION	34-38	nuclear RNA export factor 1	Homo sapiens	52-55
27008477-2	2016	The aluminium (Al(3+)) resistance of 338 wheat genotypes with different geographic origins was correlated with morphological traits and TaALMT1 and TaMATE1B alleles.	ALUMINUM ION	15-21	aluminum-activated malate transporter 1	Triticum aestivum	136-143
27008477-2	2016	The aluminium (Al(3+)) resistance of 338 wheat genotypes with different geographic origins was correlated with morphological traits and TaALMT1 and TaMATE1B alleles.	ALUMINUM ION	15-21	LOC101664696	Triticum aestivum	148-156
27008477-7	2016	The combination between the six TaALMT1 alleles and the two TaMATE1B promoters allowed the identification of 11 haplotypes that showed a high (r = 0.71, P < 0.001) correlation with Al(3+) resistance in the field, with the TaALMT1 alleles accounting for most of the correlation.	ALUMINUM ION	184-190	aluminum-activated malate transporter 1	Triticum aestivum	32-39
27008477-7	2016	The combination between the six TaALMT1 alleles and the two TaMATE1B promoters allowed the identification of 11 haplotypes that showed a high (r = 0.71, P < 0.001) correlation with Al(3+) resistance in the field, with the TaALMT1 alleles accounting for most of the correlation.	ALUMINUM ION	184-190	LOC101664696	Triticum aestivum	60-68
27008477-7	2016	The combination between the six TaALMT1 alleles and the two TaMATE1B promoters allowed the identification of 11 haplotypes that showed a high (r = 0.71, P < 0.001) correlation with Al(3+) resistance in the field, with the TaALMT1 alleles accounting for most of the correlation.	ALUMINUM ION	184-190	aluminum-activated malate transporter 1	Triticum aestivum	225-232
27008477-10	2016	The ease identification of the TaALMT1 and TaMATE1B alleles and their higher association with Al(3+) resistance along with the best genotypes identified here may be used for wheat-breeding programmes interested in increasing wheat Al(3+) resistance.	ALUMINUM ION	94-100	aluminum-activated malate transporter 1	Triticum aestivum	31-38
27008477-10	2016	The ease identification of the TaALMT1 and TaMATE1B alleles and their higher association with Al(3+) resistance along with the best genotypes identified here may be used for wheat-breeding programmes interested in increasing wheat Al(3+) resistance.	ALUMINUM ION	94-100	LOC101664696	Triticum aestivum	43-51
27008477-10	2016	The ease identification of the TaALMT1 and TaMATE1B alleles and their higher association with Al(3+) resistance along with the best genotypes identified here may be used for wheat-breeding programmes interested in increasing wheat Al(3+) resistance.	ALUMINUM ION	231-237	aluminum-activated malate transporter 1	Triticum aestivum	31-38
27008477-10	2016	The ease identification of the TaALMT1 and TaMATE1B alleles and their higher association with Al(3+) resistance along with the best genotypes identified here may be used for wheat-breeding programmes interested in increasing wheat Al(3+) resistance.	ALUMINUM ION	231-237	LOC101664696	Triticum aestivum	43-51
27088966-5	2016	The luminescence explorations demonstrated that 1 exhibits highly selective and sensitive sensing for Al(3+) over other cations with high quenching efficiency Ksv value of 1.445 x 10(4) L mol(-1) and low detection limit (1.11 muM (S/N = 3)).	ALUMINUM ION	102-108	latexin	Homo sapiens	226-229
27827954-9	2016	Finally, PA1 can also bind hard metal ions such as Al3+ and Fe3+ and the corresponding chelates are less prone to self-association.	ALUMINUM ION	51-55	PAXIP1 associated glutamate rich protein 1	Homo sapiens	9-12
27451659-3	2016	The results showed that the blue shift occurred after the substitution of Ga3+ and In3+ for Al3+ in matrix, and the intensity of emission spectrum was affected by the concentration of Ga3+ and In3+.	ALUMINUM ION	92-96	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	184-187
27451749-3	2016	The luminescence intensities of CaIn2O4:0.6%Dy3+ were enhanced by 0.2% Gd3+ or 0.2% Zn2+ ions co-doping under 367 nm excitation, but lowered by co-doping with 0.2% Al3+ ions.	ALUMINUM ION	164-168	calcineurin binding protein 1	Homo sapiens	32-36
26747046-4	2016	By contrast, bread wheat (hexaploid AABBDD, T. aestivum) shows a large variation in Al(3+) tolerance which can be attributed to a major gene (TaALMT1) located on chromosome 4D as well as to other genes of minor effect such as TaMATE1B.	ALUMINUM ION	84-90	aluminum-activated malate transporter 1	Triticum aestivum	142-149
26747046-4	2016	By contrast, bread wheat (hexaploid AABBDD, T. aestivum) shows a large variation in Al(3+) tolerance which can be attributed to a major gene (TaALMT1) located on chromosome 4D as well as to other genes of minor effect such as TaMATE1B.	ALUMINUM ION	84-90	LOC101664696	Triticum aestivum	226-234
26747046-11	2016	In contrast to bread wheat, the TaMATE1B gene was more effective than TaALMT1 in increasing the Al(3+) tolerance of durum wheat grown on acid soil.	ALUMINUM ION	96-102	LOC101664696	Triticum aestivum	32-40
26747046-11	2016	In contrast to bread wheat, the TaMATE1B gene was more effective than TaALMT1 in increasing the Al(3+) tolerance of durum wheat grown on acid soil.	ALUMINUM ION	96-102	aluminum-activated malate transporter 1	Triticum aestivum	70-77
26196932-5	2016	The sensor RBP was preliminarily applied to the determination of Al(3+) in water samples from the lake of Henan University and tap water with satisfying results.	ALUMINUM ION	65-71	SURP and G-patch domain containing 1	Homo sapiens	11-14
25663271-3	2015	Detection limits of this method for Cr(3+), Fe(3+) and Al(3+) were 3.99 muM, 4.30 muM and 1.85 muM, respectively.	ALUMINUM ION	55-61	latexin	Homo sapiens	72-75
26126410-3	2015	The sensitivity of the fluorescent based assay (0.903 muM) for Al(3+) is far below the limit recommended in the World Health Organization (WHO) guidelines for drinking water (7.41 muM).	ALUMINUM ION	63-69	latexin	Homo sapiens	54-57
26126410-3	2015	The sensitivity of the fluorescent based assay (0.903 muM) for Al(3+) is far below the limit recommended in the World Health Organization (WHO) guidelines for drinking water (7.41 muM).	ALUMINUM ION	63-69	latexin	Homo sapiens	180-183
25652390-4	2015	L is employed for imaging the Al(3+) ion in living biological cells and for the determination of the Al(3+) ion in bovine serum albumin.	ALUMINUM ION	101-107	albumin	Gallus gallus	122-135
26318146-8	2015	EGTA, CPZ, and TFP pretreatment inhibited Al(3+)-induced increase of Ca(2+) fluorescence intensity and CaM content in tea roots, and also significantly reduced Al(3+)-promoted F accumulation in tea plants.	ALUMINUM ION	42-48	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	15-18
26318146-8	2015	EGTA, CPZ, and TFP pretreatment inhibited Al(3+)-induced increase of Ca(2+) fluorescence intensity and CaM content in tea roots, and also significantly reduced Al(3+)-promoted F accumulation in tea plants.	ALUMINUM ION	160-166	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	15-18
26126410-5	2015	Receptor shows remarkable detection ability in a wide pH range of 4-11 and was successfully utilised in the determination of Al(3+) in aqueous solution of bovine serum albumin protein, and of HSO3(-) in real food samples.	ALUMINUM ION	125-131	albumin	Homo sapiens	162-175
25528504-1	2015	The complex formed by Al(3+) and cysteine in aqueous solution has been studied by potentiometry, Raman spectroscopy and DFT calculations (DFT:B3LYP/6-311++G(**)).	ALUMINUM ION	22-28	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	144-147
25663271-3	2015	Detection limits of this method for Cr(3+), Fe(3+) and Al(3+) were 3.99 muM, 4.30 muM and 1.85 muM, respectively.	ALUMINUM ION	55-61	latexin	Homo sapiens	82-85
25663271-3	2015	Detection limits of this method for Cr(3+), Fe(3+) and Al(3+) were 3.99 muM, 4.30 muM and 1.85 muM, respectively.	ALUMINUM ION	55-61	latexin	Homo sapiens	82-85
24926745-5	2014	Deletion of CKA2, a catalytic subunit of tetrameric protein kinase CK2, gives rise to the most pronounced resistance to Al(3+) by showing significantly higher growth compared to the wild type.	ALUMINUM ION	120-126	casein kinase 2 catalytic subunit CKA2	Saccharomyces cerevisiae S288C	12-16
25603599-9	2014	Compared with blank control group, solvent control group, Nec-1 control group and zVAD-fmk control group, expression of p-p38 in Al(3+) exposed group, Al(3+) plus Nec-1 group and Al(3+) plus zVAD-fmk group increased obviously (P < 0.05), and expression of p-ERK decreased significantly (P < 0.05).	ALUMINUM ION	129-135	mitogen-activated protein kinase 14	Homo sapiens	122-125
24929313-3	2014	Upon addition of Al(3+) to a solution of L, it shows 200-fold enhancement of fluorescence intensity which might be attributed to form a 2:1 stoichiometry of the binding mode of LAl(III) and the chelation enhanced fluorescence (CHEF) process at 479nm in ethanol.	ALUMINUM ION	17-23	lipase A, lysosomal acid type	Homo sapiens	177-185
24777717-5	2014	It displayed a distinct selectivity to Al(3+) among the tested cations in lutidine buffer solution (pH 6-7) with a detection limit of 1.8 muM.	ALUMINUM ION	39-45	latexin	Homo sapiens	138-141
24692647-9	2014	Barley lines expressing TaALMT1 showed significantly greater Al(3+) tolerance than all lines expressing MATE genes.	ALUMINUM ION	61-67	aluminum-activated malate transporter 1	Triticum aestivum	24-31
24956229-1	2014	Eu2PQC6 has been developed to detect Al(3+) by monitoring the quenching of the europium-based emission, with the lowest detection limit of ~32 pM and the quantitative detection range to 150 muM.	ALUMINUM ION	37-43	latexin	Homo sapiens	190-193
24737716-4	2014	In the second backcross, using "Jandaroi" as the recurrent parent, a seedling was identified where TaALMT1 on chromosome 4D was recombined with the Rht-B1b locus on chromosome 4B to yield an Al(3+)-tolerant seedling with a semi-dwarf habit.	ALUMINUM ION	191-197	aluminum-activated malate transporter 1	Triticum aestivum	99-106
24668874-1	2014	An important mechanism for Al(3+) tolerance in wheat is exudation of malate anions from the root apex through activation of malate-permeable TaALMT1 channels.	ALUMINUM ION	27-33	aluminum-activated malate transporter 1	Triticum aestivum	141-148
24626562-3	2014	The sensitivity of the fluorescent based assay (0.193 muM) for Al(3+) is far below the limit in the World Health Organization (WHO) guidelines for drinking water (7.41 muM).	ALUMINUM ION	63-69	latexin	Homo sapiens	54-57
24626562-3	2014	The sensitivity of the fluorescent based assay (0.193 muM) for Al(3+) is far below the limit in the World Health Organization (WHO) guidelines for drinking water (7.41 muM).	ALUMINUM ION	63-69	latexin	Homo sapiens	168-171
24811076-0	2014	Acetylcholinesterase inhibition-based biosensor for aluminum(III) chronoamperometric determination in aqueous media.	ALUMINUM ION	52-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
24600684-3	2014	The binding constant (Ka) of Al(3+) binding to CN was calculated to be 9.55 x 10(4) M(-1) from a Benesi-Hildebrand plot and the detection limit was evaluated to be as low as 0.10 muM (LOD = 3sigma/slope).	ALUMINUM ION	29-35	latexin	Homo sapiens	179-182
24668874-2	2014	Here, the effect of ethylene on Al(3+)-activated efflux of malate was investigated using Al(3+)-tolerant wheat genotype ET8, which has high expression of TaALMT1.	ALUMINUM ION	32-38	aluminum-activated malate transporter 1	Triticum aestivum	154-161
24668874-2	2014	Here, the effect of ethylene on Al(3+)-activated efflux of malate was investigated using Al(3+)-tolerant wheat genotype ET8, which has high expression of TaALMT1.	ALUMINUM ION	89-95	aluminum-activated malate transporter 1	Triticum aestivum	154-161
24668874-8	2014	In addition, ethylene donor (Ethrel) also inhibited Al(3+)-induced malate efflux from tobacco cells transformed with TaALMT1.	ALUMINUM ION	52-58	aluminum-activated malate transporter 1	Triticum aestivum	117-124
24668874-11	2014	These findings indicate that ethylene may behave as a negative regulator of Al(3+)-induced malate efflux by targeting TaALMT1-mediated malate efflux by an unknown mechanism.	ALUMINUM ION	76-82	aluminum-activated malate transporter 1	Triticum aestivum	118-125
24188189-10	2013	Our study highlights the need to include a comprehensive phylogenetic analysis when drawing inferences from structure-function analyses, as a significant proportion of the functional changes observed for TaALMT1 are most likely the result of alterations in the overall structural integrity of ALMT family proteins rather than modifications of specific sites involved in Al(3+) sensing.	ALUMINUM ION	370-376	aluminum-activated malate transporter 1	Triticum aestivum	204-211
24779061-1	2014	A new live-cell permeable, fluorescent probe comprised of a simple salicylimine-based Schiff base (SA1) has been developed for Al3+ with nano-molar sensitivity in aqueous media.	ALUMINUM ION	127-131	stromal antigen 1	Homo sapiens	99-102
24779061-4	2014	The presence of the DEA group in SA1 led to its dual channel emission due to the TICT state and at the same time its hydrophobic nature was also responsible for controlling the strong hydration of Al3+ ions in aqueous media which ultimately led to the high sensitivity of SA1 for Al3+.	ALUMINUM ION	197-201	stromal antigen 1	Homo sapiens	33-36
24779061-4	2014	The presence of the DEA group in SA1 led to its dual channel emission due to the TICT state and at the same time its hydrophobic nature was also responsible for controlling the strong hydration of Al3+ ions in aqueous media which ultimately led to the high sensitivity of SA1 for Al3+.	ALUMINUM ION	280-284	stromal antigen 1	Homo sapiens	33-36
24779061-4	2014	The presence of the DEA group in SA1 led to its dual channel emission due to the TICT state and at the same time its hydrophobic nature was also responsible for controlling the strong hydration of Al3+ ions in aqueous media which ultimately led to the high sensitivity of SA1 for Al3+.	ALUMINUM ION	280-284	stromal antigen 1	Homo sapiens	272-275
24779061-5	2014	The structure of SA1 was confirmed by single crystal X-ray diffraction and its binding with Al3+ was studied in detail using UVvisible, fluorescence and 1H NMR spectral studies along with mass determination.	ALUMINUM ION	92-96	stromal antigen 1	Homo sapiens	17-20
24343431-5	2014	The simple and cost effective receptor avails rapid detection of Al(3+) ions at concentrations as low as 0.42 muM and is expected to be effective for the design of efficient biological sensor.	ALUMINUM ION	65-71	latexin	Homo sapiens	110-113
24401419-5	2014	Under optimal conditions, the absorbance ratio (A620/A520) of MMT-AuNPs is linear within the Al(3+) concentration range from 1.0 to 10.0 muM, and the detection limit (3sigma) was as low as 0.53 muM.	ALUMINUM ION	93-99	latexin	Homo sapiens	137-140
24401419-5	2014	Under optimal conditions, the absorbance ratio (A620/A520) of MMT-AuNPs is linear within the Al(3+) concentration range from 1.0 to 10.0 muM, and the detection limit (3sigma) was as low as 0.53 muM.	ALUMINUM ION	93-99	latexin	Homo sapiens	194-197
25309599-5	2014	Also GP2 is negatively correlated to pH, but positively correlated to high Al(3+) concentrations.	ALUMINUM ION	75-81	glycoprotein 2	Homo sapiens	5-8
23839867-5	2013	The phosphatidate phosphohydrolase1 (pah1) pah2 double mutant showed enhanced Al susceptibility under low-P conditions, where greater levels of negatively charged phospholipids in the PM occur, which increases {Al3+}(PM) through increased PM surface negativity compared with wild-type plants.	ALUMINUM ION	211-215	Lipin family protein	Arabidopsis thaliana	37-41
23806774-0	2013	Aluminum(III) interferes with the structure and the activity of the peptidyl-prolyl cis-trans isomerase (Pin1): a new mechanism contributing to the pathogenesis of Alzheimer"s disease and cancers?	ALUMINUM ION	0-13	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	105-109
23839867-5	2013	The phosphatidate phosphohydrolase1 (pah1) pah2 double mutant showed enhanced Al susceptibility under low-P conditions, where greater levels of negatively charged phospholipids in the PM occur, which increases {Al3+}(PM) through increased PM surface negativity compared with wild-type plants.	ALUMINUM ION	211-215	phosphatidic acid phosphohydrolase 2	Arabidopsis thaliana	43-47
23829546-5	2013	We also demonstrated that the interfacial redox processes were modulated by the addition of Lewis acids such as BF3 or Al(3+) to the electrolyte media, in which the externally added Lewis acids interacted with mu-O of the dinuclear moiety within the SAMs.	ALUMINUM ION	119-125	methionine adenosyltransferase 1A	Homo sapiens	250-254
23798600-0	2013	The barley MATE gene, HvAACT1, increases citrate efflux and Al(3+) tolerance when expressed in wheat and barley.	ALUMINUM ION	60-66	HvMATE	Hordeum vulgare	11-15
23798600-3	2013	The Al(3+)-activated release of citrate from the root apices of Al(3+)-tolerant genotypes of barley is controlled by a MATE gene named HvAACT1 that encodes a citrate transport protein located on the plasma membrane.	ALUMINUM ION	4-10	HvMATE	Hordeum vulgare	119-123
23798600-3	2013	The Al(3+)-activated release of citrate from the root apices of Al(3+)-tolerant genotypes of barley is controlled by a MATE gene named HvAACT1 that encodes a citrate transport protein located on the plasma membrane.	ALUMINUM ION	64-70	HvMATE	Hordeum vulgare	119-123
23832094-7	2013	The results highlight the process of maintaining cell wall integrity as the central response to the combined exposure of diamide and Al(3+), which is mediated by the signaling pathways and transcription activation via Rlm1p and Swi6p for biosynthesis of the essential cell wall components such as glucan and chitin.	ALUMINUM ION	133-139	Rlm1p	Saccharomyces cerevisiae S288C	218-223
23832094-7	2013	The results highlight the process of maintaining cell wall integrity as the central response to the combined exposure of diamide and Al(3+), which is mediated by the signaling pathways and transcription activation via Rlm1p and Swi6p for biosynthesis of the essential cell wall components such as glucan and chitin.	ALUMINUM ION	133-139	transcriptional regulator SWI6	Saccharomyces cerevisiae S288C	228-233
23651775-0	2013	Effect of trivalent metal ion impurities (Al3+, Cr3+ and Fe3+) on the growth, structural and physical properties of potassium acid phthalate (KAP) crystals.	ALUMINUM ION	42-46	napsin A aspartic peptidase	Homo sapiens	142-145
23469825-10	2013	The highest luminescence intensity is found for Gd3(Ga,Al)5O12 with 40% of Al(3+) replaced by Ga(3+).	ALUMINUM ION	75-81	GRDX	Homo sapiens	48-51
23387946-2	2013	This study reports the carbon acidities of Calpha and C4" atoms in the Schiff bases of pyridoxal-5"-phosphate (PLP) and pyridoxamine-5"-phosphate (PMP) complexed with several biologically available metal ions (Mg2+, Ni2+, Zn2+, Cu2+, Al3+, and Fe3+).	ALUMINUM ION	234-238	pyridoxal phosphatase	Homo sapiens	111-114
23106139-5	2013	Al(3+) exposure also exacerbates DA neuronal death conferred by the human PD-associated protein alpha-synuclein.	ALUMINUM ION	0-6	synuclein alpha	Homo sapiens	96-111
23234005-4	2012	The activities of CAT and SOD in Bo 02, SOD in Bo 15, CAT and POD in Sl 08 increased significantly under Al3+ stress.	ALUMINUM ION	105-109	superoxide dismutase 1	Homo sapiens	26-29
23234005-4	2012	The activities of CAT and SOD in Bo 02, SOD in Bo 15, CAT and POD in Sl 08 increased significantly under Al3+ stress.	ALUMINUM ION	105-109	superoxide dismutase 1	Homo sapiens	40-43
22824345-5	2012	We show that Al3+ at physiologically relevant concentrations and tau phosphorylation by GSK-3beta exert synergistic effects on the formation of a distinct SDS-resistant tau oligomer species even at nanomolar protein concentration.	ALUMINUM ION	13-17	glycogen synthase kinase 3 alpha	Homo sapiens	88-97
23383499-5	2012	The proposed quantitative method was successfully applied with 0-0.50% error for the determination of Co2+ from Ni2+ in spiked samples of bauxite, soil and rock containing common cations such as Al3+, Fe2+, Ti4+, Zn2+, Mn2+, Cu2+, Cr6+, Mg2+ etc.	ALUMINUM ION	195-199	complement C2	Homo sapiens	102-105
22824345-5	2012	We show that Al3+ at physiologically relevant concentrations and tau phosphorylation by GSK-3beta exert synergistic effects on the formation of a distinct SDS-resistant tau oligomer species even at nanomolar protein concentration.	ALUMINUM ION	13-17	microtubule associated protein tau	Homo sapiens	169-172
22824345-6	2012	Moreover, tau phosphorylation and Al3+ as well as Fe3+ enhanced both formation of mixed oligomers and recruitment of alpha-synuclein in pre-formed tau oligomers.	ALUMINUM ION	34-38	synuclein alpha	Homo sapiens	117-132
22824345-6	2012	Moreover, tau phosphorylation and Al3+ as well as Fe3+ enhanced both formation of mixed oligomers and recruitment of alpha-synuclein in pre-formed tau oligomers.	ALUMINUM ION	34-38	microtubule associated protein tau	Homo sapiens	147-150
22446753-2	2012	It was found that ferric ion (Fe(3+)) could selectively quench the fluorescence of 2PC-PPH, whereas many other metal ions, such as Mn(2+), Zn(2+), Cu(2+), K(+), Al(3+), Ca(2+), Ni(2+), Co(2+), Cr(3+) and Fe(2+), could not quench its fluorescence.	ALUMINUM ION	161-167	enolase 1	Homo sapiens	87-90
21216965-1	2011	Abnormally high concentrations of Zn(2+), Cu(2+), and Fe(3+) are present along with amyloid-beta (Abeta) in the senile plaques in Alzheimer disease, where Al(3+) is also detected.	ALUMINUM ION	155-161	amyloid beta precursor protein	Homo sapiens	98-103
22403011-9	2012	A dysfunctional membrane-bound Pdr5p terminates the detoxification pathway for Al(3+) at the final step, leading to intracellular Al(3+) accumulation and hence toxicity.	ALUMINUM ION	79-85	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	31-36
22403011-9	2012	A dysfunctional membrane-bound Pdr5p terminates the detoxification pathway for Al(3+) at the final step, leading to intracellular Al(3+) accumulation and hence toxicity.	ALUMINUM ION	130-136	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	31-36
20926158-8	2011	Moreover, P deficiency led to a greater proportion of the PEPC-derived organic acids to be exuded during Al(3+) toxicity.	ALUMINUM ION	105-111	phosphoenolpyruvate carboxylase	Solanum lycopersicum	58-62
20926158-9	2011	These results indicate that P-status can influence the response to Al(3+) by inducing a greater utilisation of PEPC-derived organic acids for Al(3+) detoxification.	ALUMINUM ION	67-73	phosphoenolpyruvate carboxylase	Solanum lycopersicum	111-115
20926158-9	2011	These results indicate that P-status can influence the response to Al(3+) by inducing a greater utilisation of PEPC-derived organic acids for Al(3+) detoxification.	ALUMINUM ION	142-148	phosphoenolpyruvate carboxylase	Solanum lycopersicum	111-115
21216965-11	2011	In conclusion, Zn(2+), Cu(2+), Fe(3+), and Al(3+) adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.	ALUMINUM ION	43-49	amyloid beta precursor protein	Homo sapiens	110-115
21216965-11	2011	In conclusion, Zn(2+), Cu(2+), Fe(3+), and Al(3+) adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.	ALUMINUM ION	43-49	amyloid beta precursor protein	Homo sapiens	123-128
21687640-2	2011	We studied the inhibitory effects of Al(3+) on the activity and conformation of manganese-containing SOD (Mn-SOD).	ALUMINUM ION	37-43	superoxide dismutase 2	Homo sapiens	80-104
21146454-1	2011	In this work, the toxic influence of metallic ions (Na+, Cu2+, Al3+) on the serum albumin were studied by fluorescence, resonance light scattering (RLS), synchronous fluorescence, UV-vis absorption and circular dichroism (CD) spectroscopy.	ALUMINUM ION	63-67	albumin	Homo sapiens	76-89
22335104-6	2011	According to the analytical results obtained from X-ray diffraction, laser Raman spectrum, X-ray energy dispersive spectrometer, and Zeta potential, the removal mechanism of Pb(II) and Cu(II) by using foitite can be explained as following: firstly, the existence of an electrostatic field around foitite particles can attract heavy metal ions and consequently combine heavy metal ions with OH; secondly, heavy metal ions in the solution are exchanged with the Fe3+ and Al3+ in the foitite.	ALUMINUM ION	469-473	submaxillary gland androgen regulated protein 3B	Homo sapiens	174-191
21687640-2	2011	We studied the inhibitory effects of Al(3+) on the activity and conformation of manganese-containing SOD (Mn-SOD).	ALUMINUM ION	37-43	superoxide dismutase 1	Homo sapiens	101-104
21687640-3	2011	Mn-SOD was significantly inactivated by Al(3+) in a dose-dependent manner.	ALUMINUM ION	40-46	superoxide dismutase 2	Homo sapiens	0-6
21687640-4	2011	The kinetic studies showed that Al(3+) inactivated Mn-SOD follows the first-order reaction.	ALUMINUM ION	32-38	superoxide dismutase 2	Homo sapiens	51-57
21687640-5	2011	Al(3+) increased the degree of secondary structure of Mn-SOD and also disrupted the tertiary structure of Mn-SOD, which directly resulted in enzyme inactivation.	ALUMINUM ION	0-6	superoxide dismutase 2	Homo sapiens	54-60
21687640-5	2011	Al(3+) increased the degree of secondary structure of Mn-SOD and also disrupted the tertiary structure of Mn-SOD, which directly resulted in enzyme inactivation.	ALUMINUM ION	0-6	superoxide dismutase 2	Homo sapiens	106-112
21687640-6	2011	We further simulated the docking between Mn-SOD and Al(3+) (binding energy for Dock 6.3: -14.07 kcal/mol) and suggested that ASP152 and GLU157 residues were predicted to interact with Al(3+), which are not located in the Mn-contained active site.	ALUMINUM ION	52-58	dedicator of cytokinesis 6	Homo sapiens	79-85
21687640-7	2011	Our results provide insight into the inactivation of Mn-SOD during unfolding in the presence of Al(3+) and allow us to describe a ligand binding via inhibition kinetics combined with the computational prediction.	ALUMINUM ION	96-102	superoxide dismutase 2	Homo sapiens	53-59
21417790-1	2010	BACKGROUND: Complexation of five metal cations, Fe(3+), Al(3+), Zn(2+), Cu(2+) and Mg(2+) with four fluoroquinolones, levofloxacin, sparfloxacin, ciprofloxacin hydrochloride and enrofloxacin and human serum albumin (HSA) has been studied for better understanding of bioavailability of drugs interacting with metals and proteins.	ALUMINUM ION	56-62	albumin	Homo sapiens	201-214
20804458-4	2010	The large genotypic variation for Al(3+) resistance in wheat is largely controlled by expression of an anion channel, TaALMT1, which releases malate anions from the root apices.	ALUMINUM ION	34-40	aluminum-activated malate transporter 1	Triticum aestivum	118-125
20804458-6	2010	We investigated the evolution of this trait in wheat, and demonstrated that it has multiple independent origins that enhance Al(3+) resistance by increasing TaALMT1 expression.	ALUMINUM ION	125-131	aluminum-activated malate transporter 1	Triticum aestivum	157-164
20663086-1	2010	Al3+ -resistant cultivars of wheat (Triticum aestivum L.) release malate through the Al3+ -activated anion transport protein Triticum aestivum aluminum-activated malate transporter 1 (TaALMT1).	ALUMINUM ION	85-89	aluminum-activated malate transporter 1	Triticum aestivum	184-191
20663086-2	2010	Expression of TaALMT1 in Xenopus oocytes and tobacco suspension cells enhances the basal transport activity (inward and outward currents present in the absence of external Al3+, and generates the same Al3+ -activated currents (reflecting the Al3+-dependent transport function) as observed in wheat cells.	ALUMINUM ION	172-176	aluminum-activated malate transporter 1	Triticum aestivum	14-21
20663086-2	2010	Expression of TaALMT1 in Xenopus oocytes and tobacco suspension cells enhances the basal transport activity (inward and outward currents present in the absence of external Al3+, and generates the same Al3+ -activated currents (reflecting the Al3+-dependent transport function) as observed in wheat cells.	ALUMINUM ION	201-205	aluminum-activated malate transporter 1	Triticum aestivum	14-21
20663086-2	2010	Expression of TaALMT1 in Xenopus oocytes and tobacco suspension cells enhances the basal transport activity (inward and outward currents present in the absence of external Al3+, and generates the same Al3+ -activated currents (reflecting the Al3+-dependent transport function) as observed in wheat cells.	ALUMINUM ION	201-205	aluminum-activated malate transporter 1	Triticum aestivum	14-21
20663086-3	2010	We investigated the amino acid residues involved in this Al3+-dependent transport activity by generating a series of mutations to the TaALMT1 protein.	ALUMINUM ION	57-61	aluminum-activated malate transporter 1	Triticum aestivum	134-141
20663086-8	2010	Al3+-dependent transport activity was recovered by fusing the N-terminal region of TaALMT1 with the C-terminal region of AtALMT1, a homolog from Arabidopsis.	ALUMINUM ION	0-4	aluminum-activated malate transporter 1	Triticum aestivum	83-90
20663086-8	2010	Al3+-dependent transport activity was recovered by fusing the N-terminal region of TaALMT1 with the C-terminal region of AtALMT1, a homolog from Arabidopsis.	ALUMINUM ION	0-4	aluminum-activated malate transporter 1	Arabidopsis thaliana	121-128
20619964-7	2010	Determination of aluminium(III) was carried out in sea water, river water, tap water and haemodialysis fluids samples.	ALUMINUM ION	17-31	nuclear RNA export factor 1	Homo sapiens	75-78
20195663-3	2010	The reaction thermodynamics and micro-mechanism between Al3+ and Hasp- (or asp2-) in aqueous phase have been investigated by the combined application of supramolecular model and polarizable continuum IEFPCM solvent model, firstly revealing Al3+ interfering in the biological processes of aspartic acid.	ALUMINUM ION	56-60	beta-secretase 1	Homo sapiens	75-79
20663086-1	2010	Al3+ -resistant cultivars of wheat (Triticum aestivum L.) release malate through the Al3+ -activated anion transport protein Triticum aestivum aluminum-activated malate transporter 1 (TaALMT1).	ALUMINUM ION	0-4	aluminum-activated malate transporter 1	Triticum aestivum	184-191
20338951-10	2010	CONCLUSIONS: The Al(3+) resistance of wheat was increased by enhancing TaALMT1 expression with biotechnology.	ALUMINUM ION	17-23	aluminum-activated malate transporter 1	Triticum aestivum	71-78
20176888-2	2010	The first member of this family to be cloned and characterized, TaALMT1, is responsible for most of the natural variation of Al(3+) resistance in wheat.	ALUMINUM ION	125-131	aluminum-activated malate transporter 1	Triticum aestivum	64-71
19858117-7	2010	There was less inhibition of root elongation by Al(3+) in aux1-7 and pin2 mutants than in the wild type.	ALUMINUM ION	48-54	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	58-62
19858117-7	2010	There was less inhibition of root elongation by Al(3+) in aux1-7 and pin2 mutants than in the wild type.	ALUMINUM ION	48-54	Auxin efflux carrier family protein	Arabidopsis thaliana	69-73
19858117-11	2010	Al(3+) and ACC increased transcripts of AUX1 and PIN2, and this effect was no longer observed in the presence of AVG and Co(2+).	ALUMINUM ION	0-6	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	40-44
19858117-11	2010	Al(3+) and ACC increased transcripts of AUX1 and PIN2, and this effect was no longer observed in the presence of AVG and Co(2+).	ALUMINUM ION	0-6	Auxin efflux carrier family protein	Arabidopsis thaliana	49-53
19858117-12	2010	These findings indicate that Al(3+)-induced ethylene production is likely to act as a signal to alter auxin distribution in roots by disrupting AUX1- and PIN2-mediated auxin polar transport, leading to arrest of root elongation.	ALUMINUM ION	29-35	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	144-148
19858117-12	2010	These findings indicate that Al(3+)-induced ethylene production is likely to act as a signal to alter auxin distribution in roots by disrupting AUX1- and PIN2-mediated auxin polar transport, leading to arrest of root elongation.	ALUMINUM ION	29-35	Auxin efflux carrier family protein	Arabidopsis thaliana	154-158
18463798-3	2008	A metal determination study clearly demonstrated that Al(3+) induced the incorporation of Zn(2+) into zrt1Delta cells, probably through the low-affinity Zn(2+) transporter Zrt2p, given that the zrt1Deltazrt2Delta double mutant did not show Al-induced growth enhancement.	ALUMINUM ION	54-60	low-affinity Zn(2+) transporter ZRT2	Saccharomyces cerevisiae S288C	172-177
19916941-5	2009	NEIL1 was inhibited by Al3+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+, and Fe2+ in Tris-HCl buffer and by Cd2+, Zn2+, Cu2+, and Fe2+ in potassium phosphate buffer.	ALUMINUM ION	23-27	nei like DNA glycosylase 1	Homo sapiens	0-5
19563436-2	2009	Pre-incubation of Xenopus laevis oocytes expressing TaALMT1 with protein kinase inhibitors (K252a and staurosporine) strongly inhibited both basal and Al(3+)-enhanced TaALMT1-mediated inward currents (malate efflux).	ALUMINUM ION	151-157	aluminum-activated malate transporter 1	Triticum aestivum	52-59
19563436-2	2009	Pre-incubation of Xenopus laevis oocytes expressing TaALMT1 with protein kinase inhibitors (K252a and staurosporine) strongly inhibited both basal and Al(3+)-enhanced TaALMT1-mediated inward currents (malate efflux).	ALUMINUM ION	151-157	aluminum-activated malate transporter 1	Triticum aestivum	167-174
19563436-10	2009	These findings indicate that S384 is an essential residue regulating TaALMT1 activity via direct protein phosphorylation, which precedes Al(3+) enhancement of transport activity.	ALUMINUM ION	137-143	aluminum-activated malate transporter 1	Triticum aestivum	69-76
18691903-7	2008	For example, alpha-synuclein is a protein associated in the pathology of Parkinson"s disease, which is known to aggregate more rapidly in the presence of Al3+ and Cu2+.	ALUMINUM ION	154-158	synuclein alpha	Homo sapiens	13-28
18691903-8	2008	The 18C6 SNAPP distributions for alpha-synuclein change dramatically in the presence of 3 microM Al3+, revealing that Al3+ binding causes a significant change in the conformational dynamics of the monomeric form of this disordered protein.	ALUMINUM ION	97-101	synuclein alpha	Homo sapiens	33-48
18691903-8	2008	The 18C6 SNAPP distributions for alpha-synuclein change dramatically in the presence of 3 microM Al3+, revealing that Al3+ binding causes a significant change in the conformational dynamics of the monomeric form of this disordered protein.	ALUMINUM ION	118-122	synuclein alpha	Homo sapiens	33-48
17361033-2	2007	So far Al(3+) has received much less attention than other biometals in terms of interaction with Abeta.	ALUMINUM ION	7-13	amyloid beta precursor protein	Rattus norvegicus	97-102
18676980-1	2008	TaALMT1 encodes a putative transport protein associated with Al(3+)-activated efflux of malate from wheat root apices.	ALUMINUM ION	61-67	aluminum-activated malate transporter 1	Triticum aestivum	0-7
18676980-12	2008	We show that the Al(3+)-activated currents measured in TaALMT1-transformed tobacco cells are identical to the Al(3+)-activated currents observed in the root cells of wheat, indicating that TaALMT1 alone is likely to be responsible for those endogenous currents.	ALUMINUM ION	17-23	aluminum-activated malate transporter 1	Triticum aestivum	55-62
18676980-12	2008	We show that the Al(3+)-activated currents measured in TaALMT1-transformed tobacco cells are identical to the Al(3+)-activated currents observed in the root cells of wheat, indicating that TaALMT1 alone is likely to be responsible for those endogenous currents.	ALUMINUM ION	17-23	aluminum-activated malate transporter 1	Triticum aestivum	189-196
18221783-4	2008	In whole vessel segments, the GPRC6A activators, 300 microM l-ornithine and 100 microM Al(3+), induced endothelium-dependent myocyte hyperpolarizations sensitive to 10 microM TRAM-34, a blocker of intermediate conductance, Ca(2+)-sensitive K(+) channels (IK(Ca)).	ALUMINUM ION	87-93	G protein-coupled receptor, class C, group 6, member A	Rattus norvegicus	30-36
18221783-7	2008	In the presence of 300 microM l-ornithine or 100 microM Al(3+), myocyte hyperpolarizations to calindol were potentiated whereas this potentiation and hyperpolarizations to l-ornithine were lost following incubation with an anti-GPRC6A antibody.	ALUMINUM ION	56-62	G protein-coupled receptor, class C, group 6, member A	Rattus norvegicus	228-234
18550686-5	2008	Although the activity of TaALMT1 is highly dependent on the presence of extracellular Al(3+) (K(m1/2) of approximately 5 microm Al(3+) activity), TaALMT1 is functionally active and can mediate ion transport in the absence of extracellular Al(3+).	ALUMINUM ION	86-92	aluminum-activated malate transporter 1	Triticum aestivum	25-32
18550686-5	2008	Although the activity of TaALMT1 is highly dependent on the presence of extracellular Al(3+) (K(m1/2) of approximately 5 microm Al(3+) activity), TaALMT1 is functionally active and can mediate ion transport in the absence of extracellular Al(3+).	ALUMINUM ION	128-134	aluminum-activated malate transporter 1	Triticum aestivum	25-32
18550686-5	2008	Although the activity of TaALMT1 is highly dependent on the presence of extracellular Al(3+) (K(m1/2) of approximately 5 microm Al(3+) activity), TaALMT1 is functionally active and can mediate ion transport in the absence of extracellular Al(3+).	ALUMINUM ION	128-134	aluminum-activated malate transporter 1	Triticum aestivum	146-153
18550686-5	2008	Although the activity of TaALMT1 is highly dependent on the presence of extracellular Al(3+) (K(m1/2) of approximately 5 microm Al(3+) activity), TaALMT1 is functionally active and can mediate ion transport in the absence of extracellular Al(3+).	ALUMINUM ION	128-134	aluminum-activated malate transporter 1	Triticum aestivum	25-32
18550686-5	2008	Although the activity of TaALMT1 is highly dependent on the presence of extracellular Al(3+) (K(m1/2) of approximately 5 microm Al(3+) activity), TaALMT1 is functionally active and can mediate ion transport in the absence of extracellular Al(3+).	ALUMINUM ION	128-134	aluminum-activated malate transporter 1	Triticum aestivum	146-153
17869436-9	2007	The present results indicated that Al(3+) enhanced the function of nAChR and this potentiation might underlie the neurological alteration induced by Al(3+).	ALUMINUM ION	35-41	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	67-72
17869436-9	2007	The present results indicated that Al(3+) enhanced the function of nAChR and this potentiation might underlie the neurological alteration induced by Al(3+).	ALUMINUM ION	149-155	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	67-72
18071845-7	2008	Metal ions (Zn2+ and Al3+) inhibited the reaction of peroxidase with p-coumarate and affected the cooxidation rate of ascorbate and the peroxidase reaction in the same manner with all substrates used.	ALUMINUM ION	21-25	peroxidase	Glycine max	53-63
18071845-7	2008	Metal ions (Zn2+ and Al3+) inhibited the reaction of peroxidase with p-coumarate and affected the cooxidation rate of ascorbate and the peroxidase reaction in the same manner with all substrates used.	ALUMINUM ION	21-25	peroxidase	Glycine max	136-146
17869436-3	2007	In the present study, the actions of Al(3+) on the nicotinic acetylcholine receptor (nAChR) were investigated by whole-cell patch clamp technique in acutely isolated rat trigeminal ganglion neurons.	ALUMINUM ION	37-43	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	51-83
17869436-3	2007	In the present study, the actions of Al(3+) on the nicotinic acetylcholine receptor (nAChR) were investigated by whole-cell patch clamp technique in acutely isolated rat trigeminal ganglion neurons.	ALUMINUM ION	37-43	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	85-90
17869436-6	2007	Al(3+) appeared to increase the affinity of nicotine to nAChR but not the efficacy.	ALUMINUM ION	0-6	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	56-61
17178417-2	2007	A highly sensitive and selective capillary zone electrophoresis with laser-induced fluorescence detection (CZE-LIF) for Al(3+) and Ga(3+) was developed using a calcein 4",5"-isomer as a pre-capillary complexing agent.	ALUMINUM ION	120-126	LIF interleukin 6 family cytokine	Homo sapiens	111-114
17300980-3	2007	AT3 variants showed an intrinsic propensity to misfolding/aggregation; on the other hand, Zn(2+) and Al(3+) strongly stimulated the amplitude and kinetics of these conformational conversions.	ALUMINUM ION	101-107	ataxin 3	Homo sapiens	0-3
16679054-3	2006	Meanwhile, the static fluorescence quenching mechanism further revealed the existing of molecular complex of SOD with Al(3+).	ALUMINUM ION	118-124	superoxide dismutase 1	Homo sapiens	109-112
16947006-5	2006	NaF was used to leach the Al(3+) ion from the MIP.	ALUMINUM ION	26-32	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
16488599-6	2006	The electrochemical activity of the CAT-modified electrode was increased with the addition of Al(3+).	ALUMINUM ION	94-100	catalase	Homo sapiens	36-39
16488599-7	2006	The experimental results of voltammetry and fluorescence spectroscopy indicated that the conformation of CAT molecule was altered by the formation of Al-CAT complex with Al(3+), which may influence the activity of CAT.	ALUMINUM ION	170-176	catalase	Homo sapiens	105-108
16488599-7	2006	The experimental results of voltammetry and fluorescence spectroscopy indicated that the conformation of CAT molecule was altered by the formation of Al-CAT complex with Al(3+), which may influence the activity of CAT.	ALUMINUM ION	170-176	catalase	Homo sapiens	153-156
16488599-7	2006	The experimental results of voltammetry and fluorescence spectroscopy indicated that the conformation of CAT molecule was altered by the formation of Al-CAT complex with Al(3+), which may influence the activity of CAT.	ALUMINUM ION	170-176	catalase	Homo sapiens	153-156
16301797-7	2005	The highly similar domain-closed structure of the Al(3+)-bound form may permit the binding of Al(3+)-bound transferrin to the transferrin receptor.	ALUMINUM ION	50-56	transferrin	Homo sapiens	107-118
16570973-1	2006	Theoretical Raman spectra of the melts of NaF/AlF3 mixtures have been obtained from computer simulations in order to examine how the Raman spectra reflect the coordination structure around the Al3+ ions.	ALUMINUM ION	193-197	C-X-C motif chemokine ligand 8	Homo sapiens	42-45
16471999-0	2006	Synthesis, characterization, and hydrolysis of aluminum(III) compounds bearing the C6F5-substituted beta-diketiminate HC[(CMe)(NC6F5)]2 (L) ligand.	ALUMINUM ION	47-60	down-regulator of transcription 1	Homo sapiens	127-135
16471633-3	2006	Our simulations are able to reproduce the experimentally observed trend: (i) the normal spinel is calculated to be the stable structure at static and low-temperature conditions, and (ii) as the temperature increases, the preference of structures with Al3+ at tetrahedral sites (and Co2+ at octahedral sites) is found to progress following an asymptotic conduct.	ALUMINUM ION	251-255	complement C2	Homo sapiens	282-285
16301797-7	2005	The highly similar domain-closed structure of the Al(3+)-bound form may permit the binding of Al(3+)-bound transferrin to the transferrin receptor.	ALUMINUM ION	50-56	transferrin	Homo sapiens	126-137
16301797-7	2005	The highly similar domain-closed structure of the Al(3+)-bound form may permit the binding of Al(3+)-bound transferrin to the transferrin receptor.	ALUMINUM ION	94-100	transferrin	Homo sapiens	107-118
16301797-7	2005	The highly similar domain-closed structure of the Al(3+)-bound form may permit the binding of Al(3+)-bound transferrin to the transferrin receptor.	ALUMINUM ION	94-100	transferrin	Homo sapiens	126-137
16301797-9	2005	These findings support the participation of transferrin in the transport of Al(3+) ions in vivo.	ALUMINUM ION	76-82	transferrin	Homo sapiens	44-55
18970238-4	2005	Obtained sorbents SGIII and SGIV, respectively, were used for aluminum(III) determination by diffuse reflectance and spectrophotometric methods.	ALUMINUM ION	62-75	secretogranin III	Homo sapiens	18-23
15964544-0	2005	Al(3+) interaction sites of calmodulin and the Al(3+) effect on target binding of calmodulin.	ALUMINUM ION	0-6	calmodulin 1	Homo sapiens	28-38
15964544-0	2005	Al(3+) interaction sites of calmodulin and the Al(3+) effect on target binding of calmodulin.	ALUMINUM ION	0-6	calmodulin 1	Homo sapiens	82-92
15964544-0	2005	Al(3+) interaction sites of calmodulin and the Al(3+) effect on target binding of calmodulin.	ALUMINUM ION	47-53	calmodulin 1	Homo sapiens	82-92
15964544-1	2005	The interaction between calmodulin (CaM) and Al(3+) was studied by spectroscopic methods.	ALUMINUM ION	45-51	calmodulin 1	Homo sapiens	24-34
15964544-1	2005	The interaction between calmodulin (CaM) and Al(3+) was studied by spectroscopic methods.	ALUMINUM ION	45-51	calmodulin 1	Homo sapiens	36-39
15964544-4	2005	It is thought that Al(3+) interaction to the middle of the central helix is a key for the property of CaM"s target recognition.	ALUMINUM ION	19-25	calmodulin 1	Homo sapiens	102-105
15964544-5	2005	If the structure and/or flexibility of the central helix are/is changed by Al(3+), target affinity to CaM must be influenced by Al(3+).	ALUMINUM ION	75-81	calmodulin 1	Homo sapiens	102-105
15964544-6	2005	Thus, we performed surface plasmon resonance experiments to observe the effect of Al(3+) on the target recognition by CaM.	ALUMINUM ION	82-88	calmodulin 1	Homo sapiens	118-121
15964544-7	2005	The data clearly indicated that target affinity to CaM is reduced by addition of Al(3+).	ALUMINUM ION	81-87	calmodulin 1	Homo sapiens	51-54
15504453-10	2004	Thus, our results indicated that Al3+, Ga3+, and In3+ inhibit PBGS by competing with Zn2+, whereas Tl3+ and In3+ inhibit bovine PBGS by directly oxidizing essential sulfhydryl groups.	ALUMINUM ION	33-37	aminolevulinate dehydratase	Bos taurus	128-132
15588231-11	2005	Al3+ at a concentration of 20 mM increases Plb1p activity in vitro by 8-fold and leads to a 9-fold increase in GroPCho release by whole cells.	ALUMINUM ION	0-4	lysophospholipase	Saccharomyces cerevisiae S288C	43-48
15588231-14	2005	Deletion of PLB3 leads to increased sensitivity to toxic Al3+.	ALUMINUM ION	57-61	lysophospholipase	Saccharomyces cerevisiae S288C	12-16
15473549-3	2004	In all soils solubilized Al3+ is predominantly associated with NO3- and with some organic bases in the coarse-textured soils with undisturbed or previously plowed spodic B horizon.	ALUMINUM ION	25-29	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
15504453-2	2004	The mechanism underlying the PBGS inhibition by elements of Group 13 metals (Al3+, Ga3+, In3+, and Tl3+) has not yet been determined.	ALUMINUM ION	77-81	aminolevulinate dehydratase	Bos taurus	29-33
15504453-4	2004	Al3+, Ga3+, and In(3+i) inhibited purified hepatic bovine PBGS, and the IC50 for PBGS inhibition by Ga3+ (IC50 = 442 +/- 63 micromol l(-1)) was higher than that for Al3+ (IC50 = 319 +/- 41 micromol l(-1)) and In3+ (IC50 = 298 +/- 44 micromol l(-1)).	ALUMINUM ION	0-4	aminolevulinate dehydratase	Bos taurus	58-62
15504453-4	2004	Al3+, Ga3+, and In(3+i) inhibited purified hepatic bovine PBGS, and the IC50 for PBGS inhibition by Ga3+ (IC50 = 442 +/- 63 micromol l(-1)) was higher than that for Al3+ (IC50 = 319 +/- 41 micromol l(-1)) and In3+ (IC50 = 298 +/- 44 micromol l(-1)).	ALUMINUM ION	165-169	aminolevulinate dehydratase	Bos taurus	81-85
15504453-10	2004	Thus, our results indicated that Al3+, Ga3+, and In3+ inhibit PBGS by competing with Zn2+, whereas Tl3+ and In3+ inhibit bovine PBGS by directly oxidizing essential sulfhydryl groups.	ALUMINUM ION	33-37	aminolevulinate dehydratase	Bos taurus	62-66
12598047-0	2003	Al(3+)-mediated changes on membrane fluidity affects the activity of PI-PLC but not of PLC.	ALUMINUM ION	0-6	phospholipase C beta 1	Homo sapiens	69-75
12754258-8	2003	Although the fibrillation of alpha-synuclein was completely inhibited by methionine oxidation, the presence of certain metals (Ti3+, Zn2+, Al3+, and Pb2+) overcame this inhibition.	ALUMINUM ION	139-143	synuclein alpha	Homo sapiens	29-44
12739968-1	2003	A key issue regarding the speciation of Al(3+) in serum is how well the ligands citric acid and phosphate can compete with the iron transport protein serum transferrin for the aluminum.	ALUMINUM ION	40-46	transferrin	Homo sapiens	156-167
18969064-6	2003	The proposed method was successfully employed for the determination of Al(3+) in several commercial drinking, soft drinking (as certified reference material), and tap water samples.	ALUMINUM ION	71-77	nuclear RNA export factor 1	Homo sapiens	163-166
12598047-1	2003	We investigated whether Al(3+)-mediated changes in membrane fluidity can affect the activity of prokaryotic enzymes phospholipase C (PLC) and phospholipase C-phosphatidyl inositol specific (PI-PLC) in liposomes of phosphatidyl choline (PC), PC:phosphatidyl inositol (PI), or PC and polyphosphoinositides (PPI).	ALUMINUM ION	24-30	phospholipase C beta 1	Homo sapiens	190-196
12598047-3	2003	Al(3+) (25 and 50 microM) did not affect PLC-mediated hydrolysis of PC, PI and PIP(2), but stimulated PIP hydrolysis (48.6%).	ALUMINUM ION	0-6	prolactin induced protein	Homo sapiens	102-105
12598047-5	2003	Al(3+) significantly inhibited PIP(2) hydrolysis in a concentration-dependent (25-50 microM) manner.	ALUMINUM ION	0-6	prolactin induced protein	Homo sapiens	31-34
12598047-6	2003	Results suggest that the inhibition of PIP(2) hydrolysis by Al(3+) could be partially due to a higher lipid packing induced by Al(3+) which could affect the interaction between the enzyme and its substrate.	ALUMINUM ION	60-66	prolactin induced protein	Homo sapiens	39-42
12598047-6	2003	Results suggest that the inhibition of PIP(2) hydrolysis by Al(3+) could be partially due to a higher lipid packing induced by Al(3+) which could affect the interaction between the enzyme and its substrate.	ALUMINUM ION	127-133	prolactin induced protein	Homo sapiens	39-42
12464280-1	2002	We investigated the possible involvement of Al(3+)-induced alterations in membrane physical properties in Al(3+)-mediated inhibition of polyphosphoinositide (PPI) hydrolysis by the enzyme phosphatidylinositol-specific phospholipase C (PI-PLC).	ALUMINUM ION	44-50	phospholipase C beta 1	Homo sapiens	188-233
12464280-7	2002	The obtained results support the hypothesis that Al(3+) binding to liposomes promotes the formation of rigid clusters enriched in PPI, restricting the accessibility of the enzyme to the substrate and subsequently inhibiting PIP(2) hydrolysis by PI-PLC.	ALUMINUM ION	49-55	phospholipase C beta 1	Homo sapiens	245-251
12464280-1	2002	We investigated the possible involvement of Al(3+)-induced alterations in membrane physical properties in Al(3+)-mediated inhibition of polyphosphoinositide (PPI) hydrolysis by the enzyme phosphatidylinositol-specific phospholipase C (PI-PLC).	ALUMINUM ION	44-50	phospholipase C beta 1	Homo sapiens	235-241
12464280-1	2002	We investigated the possible involvement of Al(3+)-induced alterations in membrane physical properties in Al(3+)-mediated inhibition of polyphosphoinositide (PPI) hydrolysis by the enzyme phosphatidylinositol-specific phospholipase C (PI-PLC).	ALUMINUM ION	106-112	phospholipase C beta 1	Homo sapiens	188-233
12464280-1	2002	We investigated the possible involvement of Al(3+)-induced alterations in membrane physical properties in Al(3+)-mediated inhibition of polyphosphoinositide (PPI) hydrolysis by the enzyme phosphatidylinositol-specific phospholipase C (PI-PLC).	ALUMINUM ION	106-112	phospholipase C beta 1	Homo sapiens	235-241
12938326-5	2002	The conditional stability constant for Al3+ binding to EHPG is determined to be IgK = 14.20 +/- 0.03 in 0.1 mol.L-1 Hepes buffer at room temperature, pH 7.4 by UV difference spectra.	ALUMINUM ION	39-43	immunoglobulin kappa locus	Homo sapiens	80-83
11752386-8	2001	Both AtMGT1 and AtMGT10 are highly sensitive to Al(3+) inhibition, providing potential molecular targets for Al(3+) toxicity in plants.	ALUMINUM ION	48-54	magnesium transporter 1	Arabidopsis thaliana	5-11
11902895-1	2002	This paper is concerned with the structural data obtained for two amorphous binuclear complexes of iron(III) and aluminum(III) with chromium(III)-diethylentriaminepentaacetic acid (chromium(III)-DTPA, CrL(2)(-)) using the energy-dispersive X-ray diffraction technique.	ALUMINUM ION	113-126	interleukin 31 receptor A	Homo sapiens	201-204
11752386-8	2001	Both AtMGT1 and AtMGT10 are highly sensitive to Al(3+) inhibition, providing potential molecular targets for Al(3+) toxicity in plants.	ALUMINUM ION	109-115	magnesium transporter 1	Arabidopsis thaliana	5-11
11752386-8	2001	Both AtMGT1 and AtMGT10 are highly sensitive to Al(3+) inhibition, providing potential molecular targets for Al(3+) toxicity in plants.	ALUMINUM ION	109-115	magnesium (Mg) transporter 10	Arabidopsis thaliana	16-23
11578832-6	2001	Thus, it is possible that aluminum(III) accelerates neuronal plasticity events, for which Tyr-Tub is confirmed to be a useful marker.	ALUMINUM ION	26-39	tubby bipartite transcription factor	Mus musculus	94-97
11752386-8	2001	Both AtMGT1 and AtMGT10 are highly sensitive to Al(3+) inhibition, providing potential molecular targets for Al(3+) toxicity in plants.	ALUMINUM ION	48-54	magnesium (Mg) transporter 10	Arabidopsis thaliana	16-23
10619659-2	1999	The documented accumulation of aluminum in certain neurodegenerative diseases prompted us to test the effect of Al3+ on the activity of MAO-B in rat brain homogenate.	ALUMINUM ION	112-116	monoamine oxidase B	Rattus norvegicus	136-141
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	ALUMINUM ION	114-118	interleukin 6	Homo sapiens	32-36
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	ALUMINUM ION	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	ALUMINUM ION	158-162	interleukin 6	Homo sapiens	32-36
10602388-8	1999	The fluoride-induced effects on IL-6 and IL-8 release were strongly reduced by pretreatment with deferoxamine (an Al3+-chelator), and enhanced by addition of Al3+.	ALUMINUM ION	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
10190043-0	1999	Inhibition kinetics of human serum butyrylcholinesterase by Cd2+, Zn2+ and Al3+: comparison of the effects of metal ions on cholinesterases.	ALUMINUM ION	75-79	cholinesterase	Ovis aries	35-56
15818952-1	1999	The spectral properties of the Cr3+ broad emission band in A3M2Ge3O2 : Cr(A = Cd2+ ,Ca3+; M = Al3+,Ga3+,Sc3+) germanate garnets at room temperature are reported for the first time.	ALUMINUM ION	94-98	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	31-34
15818952-4	1999	The R-NIR emission intensity of Cr3+ is increased with some Sc3+ ions substitution for Al3+ or Ga3+ ions in octahedral sites.	ALUMINUM ION	87-91	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	32-35
10231437-2	1999	A recently identified calcium-sensing receptor (CaSR), which has been identified in target tissues for Al3+, may transduce some of the biological effects of Al3+.	ALUMINUM ION	103-107	calcium sensing receptor	Homo sapiens	22-46
10231437-2	1999	A recently identified calcium-sensing receptor (CaSR), which has been identified in target tissues for Al3+, may transduce some of the biological effects of Al3+.	ALUMINUM ION	103-107	calcium sensing receptor	Homo sapiens	48-52
10231437-2	1999	A recently identified calcium-sensing receptor (CaSR), which has been identified in target tissues for Al3+, may transduce some of the biological effects of Al3+.	ALUMINUM ION	157-161	calcium sensing receptor	Homo sapiens	22-46
10231437-2	1999	A recently identified calcium-sensing receptor (CaSR), which has been identified in target tissues for Al3+, may transduce some of the biological effects of Al3+.	ALUMINUM ION	157-161	calcium sensing receptor	Homo sapiens	48-52
10231437-6	1999	To determine if Al3+ activated CaSR, we stimulated cells transfected with rat CaSR with 10 microM to 1 mM concentrations of Al3+.	ALUMINUM ION	16-20	calcium sensing receptor	Gallus gallus	31-35
10231437-6	1999	To determine if Al3+ activated CaSR, we stimulated cells transfected with rat CaSR with 10 microM to 1 mM concentrations of Al3+.	ALUMINUM ION	124-128	calcium-sensing receptor	Rattus norvegicus	78-82
9890432-4	1999	Al3+ and Fe2+ precipitated both PHF-tau and normal tau protein as SDS-insoluble pellets.	ALUMINUM ION	0-4	microtubule associated protein tau	Homo sapiens	32-39
9890432-4	1999	Al3+ and Fe2+ precipitated both PHF-tau and normal tau protein as SDS-insoluble pellets.	ALUMINUM ION	0-4	microtubule associated protein tau	Homo sapiens	36-39
9879652-7	1998	These data suggest that Al3+ ions bind to calmodulin in the presence of Ca2+ ions, leading to an inactive, reversible conformation, instead of its physiological active form.	ALUMINUM ION	24-28	calmodulin 1	Homo sapiens	42-52
9821149-3	1998	Previous studies have shown that Al3+ alters the phosphorylation state and causes aggregation of tau in experimental animals and cultured neurons.	ALUMINUM ION	33-37	microtubule associated protein tau	Homo sapiens	97-100
9821149-4	1998	In this study Al3+ inhibited phosphorylation of tau by neuronal cdc2-like kinase and dephosphorylation of phosphorylated tau by phosphatase 2B.	ALUMINUM ION	14-18	microtubule associated protein tau	Homo sapiens	48-51
9821149-4	1998	In this study Al3+ inhibited phosphorylation of tau by neuronal cdc2-like kinase and dephosphorylation of phosphorylated tau by phosphatase 2B.	ALUMINUM ION	14-18	microtubule associated protein tau	Homo sapiens	121-124
9821149-7	1998	However upon phosphorylation, tau"s sensitivity towards Al3+ increased 3.5 fold.	ALUMINUM ION	56-60	microtubule associated protein tau	Homo sapiens	30-33
9430719-2	1998	We describe the isolation of two yeast genes (ALR1 and ALR2) which confer increased tolerance to Al3+ and Ga3+ ions when overexpressed while increasing strain sensitivity to Zn2+, Mn2+, Ni2+, Cu2+, Ca2+, and La3+ ions.	ALUMINUM ION	97-101	Mg(2+) transporter ALR1	Saccharomyces cerevisiae S288C	46-50
9430719-2	1998	We describe the isolation of two yeast genes (ALR1 and ALR2) which confer increased tolerance to Al3+ and Ga3+ ions when overexpressed while increasing strain sensitivity to Zn2+, Mn2+, Ni2+, Cu2+, Ca2+, and La3+ ions.	ALUMINUM ION	97-101	putative Mg(2+) transporter ALR2	Saccharomyces cerevisiae S288C	55-59