PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2786635-6	1989	In mice immunized with KLH, this situation did not change until day 5, when there was a sudden, explosive emergence of B cells that could form clones secreting anti-KLH IgG1.	CHEMBL2385481	23-26	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	169-173
2695285-2	1989	In the first study cysteine-containing GnRH peptides were conjugated to keyhold limpet haemocyanin (KLH) in 3 different orientations.	CHEMBL2385481	100-103	Progonadoliberin-1	Ovis aries	39-43
2695285-6	1989	In a second trial designed to evaluate carrier molecules, a cysteine-containing GnRH peptide was conjugated to either KLH, equine serum albumin, ovalbumin or tetanus toxoid.	CHEMBL2385481	118-121	Progonadoliberin-1	Ovis aries	80-84
2965683-8	1988	Recipient mice transferred with DNP-KLH-primed SDF1 spleen cells and OA-primed SDF1 spleen cells showed high-titer anti-DNP IgE and IgG antibody responses.	CHEMBL2385481	36-39	chemokine (C-X-C motif) ligand 12	Mus musculus	47-51
25190847-3	2014	In the present study, polyclonal hyperimmune sera was raised against FB1 in rabbits immunized with FB1-keyhole limpet haemocyanin (KLH).	CHEMBL2385481	131-134	TCF3 fusion partner	Homo sapiens	69-72
3583324-4	1987	LPS given before, simultaneously with or shortly after the thymus dependent (TD) antigen TNP-keyhole limpet haemocyanin (KLH) suppressed the development of anti-TNP antibody forming cells in the spleen, but serum IgM-anti-TNP titres were not reduced, suggesting a selective inhibiting effect of LPS on the local immune response in the spleen.	CHEMBL2385481	121-124	toll-like receptor 4	Mus musculus	0-3
3583324-4	1987	LPS given before, simultaneously with or shortly after the thymus dependent (TD) antigen TNP-keyhole limpet haemocyanin (KLH) suppressed the development of anti-TNP antibody forming cells in the spleen, but serum IgM-anti-TNP titres were not reduced, suggesting a selective inhibiting effect of LPS on the local immune response in the spleen.	CHEMBL2385481	121-124	toll-like receptor 4	Mus musculus	295-298
24611141-4	2014	Mice were immunized with two keyhole lympet hemocyanin (KLH)-conjugated CD34 peptides.	CHEMBL2385481	56-59	CD34 antigen	Mus musculus	72-76
29535720-8	2018	Also, p110alpha-/-DeltaT mice had enhanced anti-keyhole limpet hemocyanin (KLH) IFN-gamma, or IL-4 responses and IgG1 and IgG2b anti-KLH antibodies, using CFA or Alum as adjuvant, respectively.	CHEMBL2385481	75-78	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	6-15
29535720-8	2018	Also, p110alpha-/-DeltaT mice had enhanced anti-keyhole limpet hemocyanin (KLH) IFN-gamma, or IL-4 responses and IgG1 and IgG2b anti-KLH antibodies, using CFA or Alum as adjuvant, respectively.	CHEMBL2385481	133-136	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	6-15
25190847-3	2014	In the present study, polyclonal hyperimmune sera was raised against FB1 in rabbits immunized with FB1-keyhole limpet haemocyanin (KLH).	CHEMBL2385481	131-134	TCF3 fusion partner	Homo sapiens	99-102
20591069-3	2010	Here, we showed that active vaccination of mature rats with GIP immunoconjugates [GIP-keyhole limpet haemocyanin (KLH)] was associated with changes in body weight.	CHEMBL2385481	114-117	gastric inhibitory polypeptide	Rattus norvegicus	60-63
22217098-9	2012	dLAN rats similarly showed increased antibody production following inoculation with keyhole lymphocyte hemocyanin (KLH) and increased bactericidal capacity.	CHEMBL2385481	115-118	Laminin A	Drosophila melanogaster	0-4
20591069-3	2010	Here, we showed that active vaccination of mature rats with GIP immunoconjugates [GIP-keyhole limpet haemocyanin (KLH)] was associated with changes in body weight.	CHEMBL2385481	114-117	gastric inhibitory polypeptide	Rattus norvegicus	82-85
20591069-5	2010	Data indicated that GIP-KLH-immunized rats showed decreased spontaneous activity in the open field test, decreased cerebral glucose utilization assessed by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT), and increased apoptosis and proliferation of hippocampal granule cells marked by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) or proliferating cell nuclear antigen method.	CHEMBL2385481	24-27	gastric inhibitory polypeptide	Rattus norvegicus	20-23
14645418-3	2003	METHODS: We compared the antibody response to immunization with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid (PAM) with the saponin immunologic adjuvant QS21, in a phase I clinical trial in patients with biochemically relapsed prostate cancer.	CHEMBL2385481	113-116	tenascin C	Homo sapiens	80-85
16280381-6	2006	Surprisingly, Pb significantly enhanced IgG1 and IgG2a anti-KLH levels in the KO mice.	CHEMBL2385481	60-63	immunoglobulin heavy variable V1-9	Mus musculus	49-54
16785312-6	2006	Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization.	CHEMBL2385481	100-103	Fc gamma receptor IIa	Homo sapiens	5-9
16785312-6	2006	Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization.	CHEMBL2385481	100-103	Fc gamma receptor IIa	Homo sapiens	126-130
16785312-6	2006	Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization.	CHEMBL2385481	139-142	Fc gamma receptor IIa	Homo sapiens	5-9
16785312-6	2006	Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization.	CHEMBL2385481	139-142	Fc gamma receptor IIa	Homo sapiens	126-130
16280381-12	2006	As previously reported, Pb enhances Th2 responses in WT mice; however, in the KO mice, Pb enhanced Th1-related anti-KLH production and a Th2-related DTH.	CHEMBL2385481	116-119	negative elongation factor complex member C/D, Th1l	Mus musculus	99-102
9370925-3	1997	The IFN-gamma R -/- mice exhibited 10-fold reduced total serum KLH-specific antibody levels compared with wild-type mice after oral immunization, while after intravenous immunization, no such difference was seen, suggesting a selective impairment of mucosal immune responses.	CHEMBL2385481	63-66	interferon gamma receptor 1	Mus musculus	4-15
11472401-5	2001	KLH-induced IL-4 production of spleen cells was enhanced, while IFN-gamma production was reduced in phenytoin-treated mice.	CHEMBL2385481	0-3	interleukin 4	Mus musculus	12-16
10815887-1	2000	Our objective was to determine whether an immune response can be generated against MUC1 peptide and against tumor cell MUC1 after vaccination with MUC1-keyhole limpet hemocyanin (KLH) conjugate plus QS-21 in breast cancer patients.	CHEMBL2385481	179-182	mucin 1, cell surface associated	Homo sapiens	119-123
10815887-1	2000	Our objective was to determine whether an immune response can be generated against MUC1 peptide and against tumor cell MUC1 after vaccination with MUC1-keyhole limpet hemocyanin (KLH) conjugate plus QS-21 in breast cancer patients.	CHEMBL2385481	179-182	mucin 1, cell surface associated	Homo sapiens	119-123
11379043-4	2001	The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b.	CHEMBL2385481	79-82	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	111-115
11379043-4	2001	The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b.	CHEMBL2385481	79-82	immunoglobulin heavy variable V1-9	Mus musculus	117-122
11379043-4	2001	The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b.	CHEMBL2385481	79-82	immunoglobulin heavy constant gamma 2B	Mus musculus	127-132
11379043-5	2001	The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4).	CHEMBL2385481	76-79	interleukin 2	Mus musculus	142-146
11379043-5	2001	The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4).	CHEMBL2385481	76-79	interferon gamma	Mus musculus	151-160
11379043-5	2001	The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4).	CHEMBL2385481	76-79	interleukin 4	Mus musculus	166-190
11379043-5	2001	The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4).	CHEMBL2385481	123-126	interleukin 2	Mus musculus	142-146
11313397-7	2001	B7RP-1-Fc stimulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG2a, and IgE, whereas B7.2-Fc did not affect this production.	CHEMBL2385481	71-74	icos ligand	Mus musculus	0-6
11313397-8	2001	B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH.	CHEMBL2385481	93-96	icos ligand	Mus musculus	0-6
11313397-8	2001	B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH.	CHEMBL2385481	163-166	icos ligand	Mus musculus	0-6
11313397-8	2001	B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH.	CHEMBL2385481	163-166	interferon gamma	Mus musculus	121-130
11313397-8	2001	B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH.	CHEMBL2385481	163-166	interleukin 4	Mus musculus	132-136
11313397-8	2001	B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH.	CHEMBL2385481	163-166	interleukin 10	Mus musculus	142-147
9552008-4	1998	Sera from patients administered mAb-KLH+BCG followed by AAAP contained three distinct classes of IL-6 eluting at 30, 200, and 450 kDa, each with its characteristic ELISA reactivity and bioactivity: the 30- and 450-kDa complexes were bioactive in the B9 and Hep3B assays, but the 200-kDa complex was not.	CHEMBL2385481	36-39	interleukin 6	Homo sapiens	97-101
9370925-7	1997	Oral feeding with KLH followed by parenteral immunization resulted in strongly suppressed SFC numbers and reduced cell-mediated immunity in both wild-type and IFN-gamma R -/- mice.	CHEMBL2385481	18-21	interferon gamma receptor 1	Mus musculus	159-170
8945973-6	1996	In this paper we report that IS exposure reduces IFN-gamma levels 4 days after exposure to IS+KLH compared with immunized home cage controls.	CHEMBL2385481	94-97	interferon gamma	Rattus norvegicus	49-58
9420858-3	1995	METHODS: Five synthetic peptides were chosen based on hydropathicity analysis of ZP3 alpha, synthesized and coupled to keyhold limpet haemocyanin (KLH).	CHEMBL2385481	147-150	zona pellucida glycoprotein 4	Sus scrofa	81-90