PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2965683-8 1988 Recipient mice transferred with DNP-KLH-primed SDF1 spleen cells and OA-primed SDF1 spleen cells showed high-titer anti-DNP IgE and IgG antibody responses. CHEMBL2385481 36-39 chemokine (C-X-C motif) ligand 12 Mus musculus 47-51 16785312-6 2006 Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization. CHEMBL2385481 100-103 Fc gamma receptor IIa Homo sapiens 5-9 3583324-4 1987 LPS given before, simultaneously with or shortly after the thymus dependent (TD) antigen TNP-keyhole limpet haemocyanin (KLH) suppressed the development of anti-TNP antibody forming cells in the spleen, but serum IgM-anti-TNP titres were not reduced, suggesting a selective inhibiting effect of LPS on the local immune response in the spleen. CHEMBL2385481 121-124 toll-like receptor 4 Mus musculus 0-3 3583324-4 1987 LPS given before, simultaneously with or shortly after the thymus dependent (TD) antigen TNP-keyhole limpet haemocyanin (KLH) suppressed the development of anti-TNP antibody forming cells in the spleen, but serum IgM-anti-TNP titres were not reduced, suggesting a selective inhibiting effect of LPS on the local immune response in the spleen. CHEMBL2385481 121-124 toll-like receptor 4 Mus musculus 295-298 29535720-8 2018 Also, p110alpha-/-DeltaT mice had enhanced anti-keyhole limpet hemocyanin (KLH) IFN-gamma, or IL-4 responses and IgG1 and IgG2b anti-KLH antibodies, using CFA or Alum as adjuvant, respectively. CHEMBL2385481 75-78 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 6-15 29535720-8 2018 Also, p110alpha-/-DeltaT mice had enhanced anti-keyhole limpet hemocyanin (KLH) IFN-gamma, or IL-4 responses and IgG1 and IgG2b anti-KLH antibodies, using CFA or Alum as adjuvant, respectively. CHEMBL2385481 133-136 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 6-15 25190847-3 2014 In the present study, polyclonal hyperimmune sera was raised against FB1 in rabbits immunized with FB1-keyhole limpet haemocyanin (KLH). CHEMBL2385481 131-134 TCF3 fusion partner Homo sapiens 69-72 25190847-3 2014 In the present study, polyclonal hyperimmune sera was raised against FB1 in rabbits immunized with FB1-keyhole limpet haemocyanin (KLH). CHEMBL2385481 131-134 TCF3 fusion partner Homo sapiens 99-102 20591069-3 2010 Here, we showed that active vaccination of mature rats with GIP immunoconjugates [GIP-keyhole limpet haemocyanin (KLH)] was associated with changes in body weight. CHEMBL2385481 114-117 gastric inhibitory polypeptide Rattus norvegicus 60-63 20591069-3 2010 Here, we showed that active vaccination of mature rats with GIP immunoconjugates [GIP-keyhole limpet haemocyanin (KLH)] was associated with changes in body weight. CHEMBL2385481 114-117 gastric inhibitory polypeptide Rattus norvegicus 82-85 20591069-5 2010 Data indicated that GIP-KLH-immunized rats showed decreased spontaneous activity in the open field test, decreased cerebral glucose utilization assessed by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT), and increased apoptosis and proliferation of hippocampal granule cells marked by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) or proliferating cell nuclear antigen method. CHEMBL2385481 24-27 gastric inhibitory polypeptide Rattus norvegicus 20-23 24611141-4 2014 Mice were immunized with two keyhole lympet hemocyanin (KLH)-conjugated CD34 peptides. CHEMBL2385481 56-59 CD34 antigen Mus musculus 72-76 22217098-9 2012 dLAN rats similarly showed increased antibody production following inoculation with keyhole lymphocyte hemocyanin (KLH) and increased bactericidal capacity. CHEMBL2385481 115-118 Laminin A Drosophila melanogaster 0-4 16785312-6 2006 Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization. CHEMBL2385481 100-103 Fc gamma receptor IIa Homo sapiens 126-130 16785312-6 2006 Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization. CHEMBL2385481 139-142 Fc gamma receptor IIa Homo sapiens 5-9 16785312-6 2006 Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization. CHEMBL2385481 139-142 Fc gamma receptor IIa Homo sapiens 126-130 16280381-6 2006 Surprisingly, Pb significantly enhanced IgG1 and IgG2a anti-KLH levels in the KO mice. CHEMBL2385481 60-63 immunoglobulin heavy variable V1-9 Mus musculus 49-54 11472401-5 2001 KLH-induced IL-4 production of spleen cells was enhanced, while IFN-gamma production was reduced in phenytoin-treated mice. CHEMBL2385481 0-3 interleukin 4 Mus musculus 12-16 14645418-3 2003 METHODS: We compared the antibody response to immunization with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid (PAM) with the saponin immunologic adjuvant QS21, in a phase I clinical trial in patients with biochemically relapsed prostate cancer. CHEMBL2385481 113-116 tenascin C Homo sapiens 80-85 16280381-12 2006 As previously reported, Pb enhances Th2 responses in WT mice; however, in the KO mice, Pb enhanced Th1-related anti-KLH production and a Th2-related DTH. CHEMBL2385481 116-119 negative elongation factor complex member C/D, Th1l Mus musculus 99-102 11313397-7 2001 B7RP-1-Fc stimulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG2a, and IgE, whereas B7.2-Fc did not affect this production. CHEMBL2385481 71-74 icos ligand Mus musculus 0-6 11379043-4 2001 The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b. CHEMBL2385481 79-82 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 111-115 11379043-4 2001 The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b. CHEMBL2385481 79-82 immunoglobulin heavy variable V1-9 Mus musculus 117-122 11379043-4 2001 The assay for determining isotypes of antibodies revealed that KML-C augmented KLH-specific antibody titers of IgG1, IgG2a and IgG2b. CHEMBL2385481 79-82 immunoglobulin heavy constant gamma 2B Mus musculus 127-132 11379043-5 2001 The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4). CHEMBL2385481 76-79 interleukin 2 Mus musculus 142-146 11379043-5 2001 The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4). CHEMBL2385481 76-79 interferon gamma Mus musculus 151-160 11379043-5 2001 The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4). CHEMBL2385481 76-79 interleukin 4 Mus musculus 166-190 11379043-5 2001 The culture supernatants obtained from the splenocytes of mice treated with KLH + KML-C also showed a higher level of both KLH-specific Th-1 (IL-2 and IFN-gamma) and Th-2 type cytokine (IL-4). CHEMBL2385481 123-126 interleukin 2 Mus musculus 142-146 11313397-8 2001 B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH. CHEMBL2385481 93-96 icos ligand Mus musculus 0-6 11313397-8 2001 B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH. CHEMBL2385481 163-166 icos ligand Mus musculus 0-6 11313397-8 2001 B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH. CHEMBL2385481 163-166 interferon gamma Mus musculus 121-130 11313397-8 2001 B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH. CHEMBL2385481 163-166 interleukin 4 Mus musculus 132-136 11313397-8 2001 B7RP-1-Fc also increased the number of cells in lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 in response to KLH. CHEMBL2385481 163-166 interleukin 10 Mus musculus 142-147 10815887-1 2000 Our objective was to determine whether an immune response can be generated against MUC1 peptide and against tumor cell MUC1 after vaccination with MUC1-keyhole limpet hemocyanin (KLH) conjugate plus QS-21 in breast cancer patients. CHEMBL2385481 179-182 mucin 1, cell surface associated Homo sapiens 119-123 10815887-1 2000 Our objective was to determine whether an immune response can be generated against MUC1 peptide and against tumor cell MUC1 after vaccination with MUC1-keyhole limpet hemocyanin (KLH) conjugate plus QS-21 in breast cancer patients. CHEMBL2385481 179-182 mucin 1, cell surface associated Homo sapiens 119-123 9552008-4 1998 Sera from patients administered mAb-KLH+BCG followed by AAAP contained three distinct classes of IL-6 eluting at 30, 200, and 450 kDa, each with its characteristic ELISA reactivity and bioactivity: the 30- and 450-kDa complexes were bioactive in the B9 and Hep3B assays, but the 200-kDa complex was not. CHEMBL2385481 36-39 interleukin 6 Homo sapiens 97-101 8945973-6 1996 In this paper we report that IS exposure reduces IFN-gamma levels 4 days after exposure to IS+KLH compared with immunized home cage controls. CHEMBL2385481 94-97 interferon gamma Rattus norvegicus 49-58 9370925-3 1997 The IFN-gamma R -/- mice exhibited 10-fold reduced total serum KLH-specific antibody levels compared with wild-type mice after oral immunization, while after intravenous immunization, no such difference was seen, suggesting a selective impairment of mucosal immune responses. CHEMBL2385481 63-66 interferon gamma receptor 1 Mus musculus 4-15 9370925-7 1997 Oral feeding with KLH followed by parenteral immunization resulted in strongly suppressed SFC numbers and reduced cell-mediated immunity in both wild-type and IFN-gamma R -/- mice. CHEMBL2385481 18-21 interferon gamma receptor 1 Mus musculus 159-170 2786635-6 1989 In mice immunized with KLH, this situation did not change until day 5, when there was a sudden, explosive emergence of B cells that could form clones secreting anti-KLH IgG1. CHEMBL2385481 23-26 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 169-173 9420858-3 1995 METHODS: Five synthetic peptides were chosen based on hydropathicity analysis of ZP3 alpha, synthesized and coupled to keyhold limpet haemocyanin (KLH). CHEMBL2385481 147-150 zona pellucida glycoprotein 4 Sus scrofa 81-90 2695285-2 1989 In the first study cysteine-containing GnRH peptides were conjugated to keyhold limpet haemocyanin (KLH) in 3 different orientations. CHEMBL2385481 100-103 Progonadoliberin-1 Ovis aries 39-43 2695285-6 1989 In a second trial designed to evaluate carrier molecules, a cysteine-containing GnRH peptide was conjugated to either KLH, equine serum albumin, ovalbumin or tetanus toxoid. CHEMBL2385481 118-121 Progonadoliberin-1 Ovis aries 80-84