PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3481842-2	1987	[Gly6]-NKB [3-10] in the guinea-pig ileum and rat portal vein and [Arg3, D-Ala6]-NKB [3-10] in the guinea-pig ileum were found to be the first specific and competitive antagonists against NKB.	Hexaglycine	1-5	tachykinin-3	Cavia porcellus	7-10
2681686-1	1989	Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations.	Hexaglycine	42-46	gonadotropin releasing hormone 1	Homo sapiens	55-92
2681686-1	1989	Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations.	Hexaglycine	42-46	gonadotropin releasing hormone 1	Homo sapiens	94-98
3292705-9	1988	Superactive analogs of LHRH in which Gly6 was replaced by a D-amino acid are resistant to degradation by both endopeptidase-24.11 and -24.15.	Hexaglycine	37-41	gonadotropin releasing hormone 1	Mus musculus	23-27
3025368-10	1987	It is further suggested that the thiol protease and angiotensin-converting enzyme are also responsible for the initial minor cleavages of the Gly6-Leu7 bond and the Trp3-Ser4 bond, respectively.	Hexaglycine	142-146	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	52-81
3888610-10	1985	The appearance of LHRH degradation fragments suggests that the initial cleavage of LHRH by LHRH-DA occurs at the Tyr5-Gly6 bond at all hypothalamic levels studied.	Hexaglycine	118-122	gonadotropin releasing hormone 1	Homo sapiens	83-87
3888610-10	1985	The appearance of LHRH degradation fragments suggests that the initial cleavage of LHRH by LHRH-DA occurs at the Tyr5-Gly6 bond at all hypothalamic levels studied.	Hexaglycine	118-122	gonadotropin releasing hormone 1	Homo sapiens	83-87
7041967-1	1982	The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates.	Hexaglycine	211-215	gonadotropin releasing hormone 1	Homo sapiens	98-135
6316292-6	1983	These data demonstrate that substitution of Gly6 of LH-RH with D-Trp enhances the LH release from chicken pituitary cells to a similar extent to that observed in mammals, and indicate that the approaches used to produce active LH-RH analogs in mammals are likely to be applicable to birds.	Hexaglycine	44-48	gonadotropin releasing hormone 1	Mus musculus	52-57
6316292-6	1983	These data demonstrate that substitution of Gly6 of LH-RH with D-Trp enhances the LH release from chicken pituitary cells to a similar extent to that observed in mammals, and indicate that the approaches used to produce active LH-RH analogs in mammals are likely to be applicable to birds.	Hexaglycine	44-48	gonadotropin releasing hormone 1	Mus musculus	227-232
7041967-1	1982	The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates.	Hexaglycine	211-215	gonadotropin releasing hormone 1	Homo sapiens	137-142
6805045-2	1982	The primary cleavage point in the Tyr5-Gly6 bond giving [1-5] LH-RH and [6-10] LH-RH.	Hexaglycine	39-43	gonadotropin releasing hormone 1	Rattus norvegicus	62-67
6805045-2	1982	The primary cleavage point in the Tyr5-Gly6 bond giving [1-5] LH-RH and [6-10] LH-RH.	Hexaglycine	39-43	gonadotropin releasing hormone 1	Rattus norvegicus	79-84
20548263-3	2010	We have asked whether a hybrid molecule in which a soluble fusion protein containing CD200, CD200Fc, was linked to TGF-beta through a glycine linker (Gly6) functions as a superior immunosuppressant molecule when compared with CD200Fc or TGF-beta alone, or in combination.	Hexaglycine	150-154	CD200 antigen	Mus musculus	85-90
6994798-2	1980	This Ca2+-independent enzyme of 83 000 molecular weight (as estimated by gel filtration) cleaves LH-RH (KM = 180 microM) at the Tyr5-Gly6-His2-Trp3 bonds.	Hexaglycine	133-137	transient receptor potential cation channel subfamily C member 3	Bos taurus	143-147
32905943-12	2020	Both Galloflavin and Ellagic acid were able to form hydrogen bonds with Asp188 and Gly6 in SIRT6.	Hexaglycine	83-87	sirtuin 6	Homo sapiens	91-96
30255452-0	2019	A synonymous germline variant PALB2 c.18G>T (p.Gly6=) disrupts normal splicing in a family with pancreatic and breast cancers.	Hexaglycine	50-54	partner and localizer of BRCA2	Homo sapiens	30-35
30255452-2	2019	This study aims to characterize a novel PALB2 synonymous variant c.18G>T (p.Gly6=) identified in a family with pancreatic and breast cancers.	Hexaglycine	79-83	partner and localizer of BRCA2	Homo sapiens	40-45
30255452-3	2019	METHODS: The PALB2 c.18G>T (p.Gly6=) variant in this family was identified using Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT ).	Hexaglycine	33-37	partner and localizer of BRCA2	Homo sapiens	13-18
30255452-7	2019	CONCLUSIONS: Our results indicate that the PALB2 c.18G>T (p.Gly6=) variant is likely pathogenic.	Hexaglycine	63-67	partner and localizer of BRCA2	Homo sapiens	43-48
28883454-6	2017	Five inhibitor bound hGIIE complex structures revealed the key residues (Asn21 and Gly6) of hGIIE that are responsible for interacting with inhibitors, and illustrated the difference in the inhibitor binding pocket with other sPLA2s.	Hexaglycine	83-87	phospholipase A2 group IID	Homo sapiens	226-232
22296859-6	2012	The fusion protein that comprised of C-terminus HSA connected to N-terminus ANF via a hexaglycine linker showed the best outcome; it increased cGMP production in vitro.	Hexaglycine	86-97	natriuretic peptide type A	Mus musculus	76-79
20548263-3	2010	We have asked whether a hybrid molecule in which a soluble fusion protein containing CD200, CD200Fc, was linked to TGF-beta through a glycine linker (Gly6) functions as a superior immunosuppressant molecule when compared with CD200Fc or TGF-beta alone, or in combination.	Hexaglycine	150-154	transforming growth factor, beta 1	Mus musculus	115-123
9003519-2	1997	A single lactam bridge (gamma-carboxyl of Glu to epsilon-amino of Lys) extending from residues i to i + 3 or i to i + 4 of the proposed alpha-helical region (residues 25-31 of NPY) was introduced in des-AA7-24[Gly6]NPY.	Hexaglycine	210-214	neuropeptide Y	Homo sapiens	176-179
11596068-7	2001	Furthermore, "early" cells predominantly contain LHRH1-5-like peptide and its cleavage enzyme, metalloendopeptidase E.C.3.4.24.15 (EP24.15), which cleaves LHRH at the Tyr5-Gly6 position.	Hexaglycine	172-176	thimet oligopeptidase 1	Homo sapiens	131-138
11596068-7	2001	Furthermore, "early" cells predominantly contain LHRH1-5-like peptide and its cleavage enzyme, metalloendopeptidase E.C.3.4.24.15 (EP24.15), which cleaves LHRH at the Tyr5-Gly6 position.	Hexaglycine	172-176	gonadotropin releasing hormone 1	Homo sapiens	49-53
9419832-2	1997	Among its numerous roles in metabolizing and processing biologically-active peptides, the enzyme degrades gonadotropin-releasing hormone (GnRH) by cleaving the central Tyr5-Gly6 bond.	Hexaglycine	173-177	gonadotropin releasing hormone 1	Rattus norvegicus	106-136
9419832-2	1997	Among its numerous roles in metabolizing and processing biologically-active peptides, the enzyme degrades gonadotropin-releasing hormone (GnRH) by cleaving the central Tyr5-Gly6 bond.	Hexaglycine	173-177	gonadotropin releasing hormone 1	Rattus norvegicus	138-142
19799950-4	2010	SK84 contains a high level of glycine (15.5%) and a hexaglycine cluster motif in the N-terminal part.	Hexaglycine	52-63	ATPase inhibitor A, mitochondrial	Drosophila virilis	0-4
11956594-5	2002	Approximately 98% of GnRH hydrolysis by plasma membrane from ovarian cancers surgically removed was accounted for by the cleavage at Tyr5-Gly6 to yield (1-5)GnRH.	Hexaglycine	138-142	gonadotropin releasing hormone 1	Homo sapiens	21-25
11735414-9	2001	H3 inhibits cleavage of the Trp3-Ser4 and Tyr5-Gly6 bonds in gonadotropin releasing hormone, bonds cleaved by the ChT-L activity in the absence of H3.	Hexaglycine	47-51	transient receptor potential cation channel subfamily C member 3	Bos taurus	28-32
9623484-6	1997	In addition to LHRH and Gly6-substituted LHRH analogues, the partially purified LHRH-peptidase degraded both angiotensins I and II, but not the gonadotrophin-releasing-hormone-associated peptide derived from the LHRH precursor molecule.	Hexaglycine	24-28	gonadotropin releasing hormone 1	Rattus norvegicus	41-45
9623484-6	1997	In addition to LHRH and Gly6-substituted LHRH analogues, the partially purified LHRH-peptidase degraded both angiotensins I and II, but not the gonadotrophin-releasing-hormone-associated peptide derived from the LHRH precursor molecule.	Hexaglycine	24-28	gonadotropin releasing hormone 1	Rattus norvegicus	41-45
9623484-6	1997	In addition to LHRH and Gly6-substituted LHRH analogues, the partially purified LHRH-peptidase degraded both angiotensins I and II, but not the gonadotrophin-releasing-hormone-associated peptide derived from the LHRH precursor molecule.	Hexaglycine	24-28	gonadotropin releasing hormone 1	Rattus norvegicus	41-45
8877556-4	1996	In this paper, we elucidate the conformation of cyclo(2,10)Ac-Gly1-Pen2-Gly3-His4-Arg5-Gly6-Asp7 -Leu8-Arg9-Cys10-Ala11-NH2 (1) by NMR and molecular dynamics simulations.	Hexaglycine	87-91	threonine aldolase 1, pseudogene	Homo sapiens	62-66
8877556-4	1996	In this paper, we elucidate the conformation of cyclo(2,10)Ac-Gly1-Pen2-Gly3-His4-Arg5-Gly6-Asp7 -Leu8-Arg9-Cys10-Ala11-NH2 (1) by NMR and molecular dynamics simulations.	Hexaglycine	87-91	presenilin enhancer, gamma-secretase subunit	Homo sapiens	67-71
8175672-1	1994	The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond.	Hexaglycine	170-174	thimet oligopeptidase 1	Rattus norvegicus	4-24
7744730-3	1995	Both Thermoplasma and granulosa proteasome degrade the decapeptide GnRH at the Trp3-Ser4, Ser4-Tyr5, Tyr5-Gly6, and Gly6-Leu7 bonds.	Hexaglycine	106-110	gonadotropin releasing hormone 1	Homo sapiens	67-71
7744730-3	1995	Both Thermoplasma and granulosa proteasome degrade the decapeptide GnRH at the Trp3-Ser4, Ser4-Tyr5, Tyr5-Gly6, and Gly6-Leu7 bonds.	Hexaglycine	116-120	gonadotropin releasing hormone 1	Homo sapiens	67-71
7744730-3	1995	Both Thermoplasma and granulosa proteasome degrade the decapeptide GnRH at the Trp3-Ser4, Ser4-Tyr5, Tyr5-Gly6, and Gly6-Leu7 bonds.	Hexaglycine	116-120	beta-1,3-glucuronyltransferase 1	Homo sapiens	121-125
8175672-1	1994	The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond.	Hexaglycine	170-174	gonadotropin releasing hormone 1	Rattus norvegicus	61-91
8175672-1	1994	The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond.	Hexaglycine	170-174	gonadotropin releasing hormone 1	Rattus norvegicus	93-97
8175672-12	1994	Taken together, these results suggest that GnRH metabolism in the hypothalamus may occur via a two-step process involving first removal of Gly10-NH2 by prolyl endopeptidase, followed by cleavage by endopeptidase 24.15 at the Tyr5-Gly6 bond.	Hexaglycine	230-234	gonadotropin releasing hormone 1	Rattus norvegicus	43-47
8175672-12	1994	Taken together, these results suggest that GnRH metabolism in the hypothalamus may occur via a two-step process involving first removal of Gly10-NH2 by prolyl endopeptidase, followed by cleavage by endopeptidase 24.15 at the Tyr5-Gly6 bond.	Hexaglycine	230-234	thimet oligopeptidase 1	Rattus norvegicus	198-217
8196175-3	1994	The known point mutations that cause euthyroid hyperthyroxinemia are Ala109 (ACC) to Thr (GCC) and Gly6 (GGT) to Ser (AGT).	Hexaglycine	99-103	angiotensinogen	Homo sapiens	118-121
8407112-5	1993	It appeared that the beta-II" turn at the Tyr5-Gly6-Leu7-Arg8 central tetrapeptide is the common structure for all LHRH agonists considered.	Hexaglycine	47-51	beta-1,3-glucuronyltransferase 1	Homo sapiens	52-56
8407112-5	1993	It appeared that the beta-II" turn at the Tyr5-Gly6-Leu7-Arg8 central tetrapeptide is the common structure for all LHRH agonists considered.	Hexaglycine	47-51	gonadotropin releasing hormone 1	Homo sapiens	115-119
1654808-13	1991	MMP-3 showed doublets of approximately 47/46 and 26/25 kDa and cleaved substance P at the Gly6-Phe7 bond.	Hexaglycine	90-94	stromelysin-1	Sus scrofa	0-5
8407111-2	1993	A systematic conformational build-up procedure was performed for the LHRH molecule, pGlu1-His2-Trp3-Ser4-Tyr5-Gly6-Leu7-Arg8-Pro9-Gly10-NH 2.	Hexaglycine	110-114	gonadotropin releasing hormone 1	Homo sapiens	69-73
8407111-2	1993	A systematic conformational build-up procedure was performed for the LHRH molecule, pGlu1-His2-Trp3-Ser4-Tyr5-Gly6-Leu7-Arg8-Pro9-Gly10-NH 2.	Hexaglycine	110-114	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	95-99
8407111-2	1993	A systematic conformational build-up procedure was performed for the LHRH molecule, pGlu1-His2-Trp3-Ser4-Tyr5-Gly6-Leu7-Arg8-Pro9-Gly10-NH 2.	Hexaglycine	110-114	beta-1,3-glucuronyltransferase 1	Homo sapiens	115-119
1654826-0	1991	Genetic analysis of yeast iso-1-cytochrome c structural requirements: suppression of Gly6 replacements by an Asn52----Ile replacement.	Hexaglycine	85-89	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	26-31
1654826-1	1991	Gly6 (vertebrate numbering system) is an evolutionarily invariant amino acid located in an electron-dense region of cytochrome c. Serine, cysteine, and aspartic acid replacements of Gly6 abolished yeast iso-1-cytochrome c function, presumably by destabilizing the mature forms of the altered proteins (1).	Hexaglycine	0-4	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	203-208
2049393-2	1991	Colipase is secreted from pancreas as a procolipase and is transformed into colipase by the trypsin cleavage of the Arg5-Gly6 bond during liberation of an N-terminal pentapeptide.	Hexaglycine	121-125	colipase	Homo sapiens	0-8
2017301-7	1991	Thus, we propose that a thiol-dependent membrane-bound metallo-endopeptidase plays a major role in the initial stage of degradation of LHRH at the Tyr5-Gly6 bond in both neurons and glia.	Hexaglycine	152-156	gonadotropin releasing hormone 1	Rattus norvegicus	135-139
2261473-0	1990	Bradykinin and its Gly6 analogue are substrates of cyclophilin: a fluorine-19 magnetization transfer study.	Hexaglycine	19-23	kininogen 1	Homo sapiens	0-10
2261473-1	1990	Fluorine-19 magnetization transfer experiments have been used to determine the rates of cis/trans isomerization about the X-Pro7 peptide bond in [p-fluoro-Phe8]bradykinin (cis/trans ratio approximately 0.1) and its Gly6 analogue (cis/trans ratio approximately 0.4).	Hexaglycine	215-219	kininogen 1	Homo sapiens	160-170
2261473-3	1990	Magnetization transfer measurements over the temperature range 40-75 degrees C in the absence of enzyme give activation energies of 22.8 and 23.0 kcal/mol for [p-fluoro-Phe8]bradykinin and its Gly6 analogue, respectively.	Hexaglycine	193-197	kininogen 1	Homo sapiens	174-184
2261473-5	1990	At a peptide concentration of 2.2 mM, the catalytic activity expressed as kc per micromolar cyclophilin was determined to be 1.2 s-1/microM for [p-fluoro-Phe8]bradykinin and 0.13 s-1/microM for the Gly6 analogue.	Hexaglycine	198-202	kininogen 1	Homo sapiens	159-169