PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24380846-8	2014	Exposure of Cx50(-/-) fiber cells to La(3+) hyperpolarized the resting potential to -58 mV, which is similar to the value of resting potential measured in dKO fiber and significantly reduced the open channel noise.	lanthanum(3+)	37-43	gap junction protein, alpha 8	Mus musculus	12-16
24117252-10	2014	Riluzole-induced TRPC5 currents were potentiated by La(3+) and, utilizing TRPC5 mutants that lack La(3+) binding sites, it was confirmed that riluzole and La(3+) activate TRPC5 by different mechanisms.	lanthanum(3+)	52-58	transient receptor potential cation channel subfamily C member 5	Homo sapiens	17-22
24084605-10	2014	In UM cells, the CB1 agonist, WIN 55,212-2, induced Ca(2+) transients, which were suppressed by La(3+) and CPZ whereas CAP-induced Ca(2+) transients could also be suppressed by CB1 activation.	lanthanum(3+)	96-102	cannabinoid receptor 1	Homo sapiens	17-20
23653318-4	2013	Compared to treatment with acid rain (pH 4.5 and pH 3.0) or La3+ alone, joint stress of La3+ and acid rain affected more severely the activity of catalase and peroxidase, and induced more H2O2 accumulation and lipid peroxidation.	lanthanum(3+)	60-64	catalase-3	Glycine max	146-154
23653318-4	2013	Compared to treatment with acid rain (pH 4.5 and pH 3.0) or La3+ alone, joint stress of La3+ and acid rain affected more severely the activity of catalase and peroxidase, and induced more H2O2 accumulation and lipid peroxidation.	lanthanum(3+)	88-92	catalase-3	Glycine max	146-154
23653318-4	2013	Compared to treatment with acid rain (pH 4.5 and pH 3.0) or La3+ alone, joint stress of La3+ and acid rain affected more severely the activity of catalase and peroxidase, and induced more H2O2 accumulation and lipid peroxidation.	lanthanum(3+)	88-92	peroxidase	Glycine max	159-169
23686296-4	2013	Endothlin-1 and angiotensin II enhanced the current that could be inhibited by La(3+).	lanthanum(3+)	79-85	angiotensinogen	Homo sapiens	0-30
23707350-3	2013	Further experiments showed that the SNP-induced [Ca(2+)]c increase was specifically blocked by potent antagonists of the transient receptor potential vanilloid subtype 1 (TRPV1) channel: capsazepine, ruthenium red, and La(3+) in Ca(2+)-containing buffer.	lanthanum(3+)	219-225	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-169
23707350-3	2013	Further experiments showed that the SNP-induced [Ca(2+)]c increase was specifically blocked by potent antagonists of the transient receptor potential vanilloid subtype 1 (TRPV1) channel: capsazepine, ruthenium red, and La(3+) in Ca(2+)-containing buffer.	lanthanum(3+)	219-225	transient receptor potential cation channel subfamily V member 1	Homo sapiens	171-176
23137179-5	2012	Ang 1-7 evoked store operated Ca(2+) entry that was inhibited by La(3+) and aristolochic acid.	lanthanum(3+)	65-71	angiopoietin 1	Canis lupus familiaris	0-5
22802050-5	2012	The TRPM7-like current was potentiated by acidic pH and inhibited by La(3+) and 2-aminoethoxydiphenyl borate.	lanthanum(3+)	69-75	transient receptor potential cation channel subfamily M member 7	Homo sapiens	4-9
21411568-4	2011	This effect was reduced in a Ca(2+)-free, or voltage-gated Ca(2+) channel blocker La(3+)-containing Krebs solution and was produced by a galanin type-2/3 receptor (GalR2/R3) agonist, galanin 2-11, but not by a galanin type-1 receptor (GalR1) agonist, M617.	lanthanum(3+)	82-88	galanin receptor 2	Rattus norvegicus	164-169
21411568-4	2011	This effect was reduced in a Ca(2+)-free, or voltage-gated Ca(2+) channel blocker La(3+)-containing Krebs solution and was produced by a galanin type-2/3 receptor (GalR2/R3) agonist, galanin 2-11, but not by a galanin type-1 receptor (GalR1) agonist, M617.	lanthanum(3+)	82-88	galanin receptor 1	Rattus norvegicus	235-240
21753923-7	2011	The coordination number of both K(+) and La(3+) cations is nine, resulting in distorted KO(9) and LaO(9) polyhedra.	lanthanum(3+)	41-47	interleukin 4 induced 1	Homo sapiens	98-101
20639216-6	2010	After treatment with both La(3+) and CPA, diameters were passive in both adult and P14 MCAs, but Ca(2+) was decreased only in adult MCAs.	lanthanum(3+)	26-32	S100 calcium binding protein A9	Rattus norvegicus	83-86
19955332-5	2010	The thermotactic response was also inhibited by each of the following: La(3+), a general blocker of Ca(2+) channels; U73122, an inhibitor of phospholipase C (PLC); and 2-aminoethoxy diphenyl borate, an inhibitor of inositol 1,4,5-trisphosphate receptors (IP(3)R) and store-operated channels.	lanthanum(3+)	71-77	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	255-261
19705457-5	2010	The persistent responses were associated with a progressive reduction in cell viability that was prevented by La(3+) or peptides that block connexin 43 (Cx43) hemichannels or by inhibition of p38 MAP kinase prior to hypoxia-reoxygenation but not by treatments that block pannexin hemichannels.	lanthanum(3+)	110-116	gap junction protein, alpha 1	Rattus norvegicus	140-151
19705457-5	2010	The persistent responses were associated with a progressive reduction in cell viability that was prevented by La(3+) or peptides that block connexin 43 (Cx43) hemichannels or by inhibition of p38 MAP kinase prior to hypoxia-reoxygenation but not by treatments that block pannexin hemichannels.	lanthanum(3+)	110-116	gap junction protein, alpha 1	Rattus norvegicus	153-157
20107083-5	2010	Also, lanthanum (La(3+)) and intracellular Ca(2+) potentiated the effects of leptin.	lanthanum(3+)	17-23	leptin	Mus musculus	77-83
19683814-3	2009	In PMA-stimulated microglia, ROS production was substantially reduced upon inhibition of the non-selective cation channel TRPV1 with La(3+), ruthenium red, capsazepine and 5-iodo-resinferatoxin.	lanthanum(3+)	133-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
19036874-7	2009	CNP-induced hyperpolarization was inhibited by the K(+) channel blockers, tetraethylammonium or iberiotoxin, the nonspecific cation channel blocker, La(3+), or by depletion or repletion of extracellular Ca(2+) or K(+), respectively.	lanthanum(3+)	149-155	natriuretic peptide C	Homo sapiens	0-3
18577871-5	2009	A number of CaSR agonists, such as spermine, Gd(3+), La(3+) and neomycin, elicited a heterogeneous intracellular Ca(2+) signal, which was abolished by disruption of inositol 1,4,5-trisphosphate (InsP(3)) signaling and by depletion of intracellular stores with cyclopiazonic acid.	lanthanum(3+)	53-59	calcium sensing receptor	Homo sapiens	12-16
18577871-7	2009	Finally, aromatic amino acids, which function as allosteric activators of CaSR, potentiated the Ca(2+) response to the CaSR agonist La(3+).	lanthanum(3+)	132-138	calcium sensing receptor	Homo sapiens	74-78
18577871-7	2009	Finally, aromatic amino acids, which function as allosteric activators of CaSR, potentiated the Ca(2+) response to the CaSR agonist La(3+).	lanthanum(3+)	132-138	calcium sensing receptor	Homo sapiens	119-123
18957290-7	2008	Interestingly, the effect of caffeine and La(3+) but not nifedipine were diminished in the present of 2-APB.	lanthanum(3+)	42-48	arginyl aminopeptidase	Homo sapiens	104-107
19090984-7	2008	APalpha-induced intracellular calcium concentration increase was not observed in calcium depleted medium and was blocked in the presence of the broad spectrum calcium channel blocker La3+, or the L-type calcium channel blocker nifedipine.	lanthanum(3+)	183-187	glutamyl aminopeptidase	Rattus norvegicus	0-7
18810761-3	2008	In this study, La3+ treatment enhanced in vitro osteoblast differentiation as evidenced by promoting alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion, and matrix mineralization.	lanthanum(3+)	15-19	alkaline phosphatase, placental	Homo sapiens	101-121
18810761-3	2008	In this study, La3+ treatment enhanced in vitro osteoblast differentiation as evidenced by promoting alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion, and matrix mineralization.	lanthanum(3+)	15-19	alkaline phosphatase, placental	Homo sapiens	123-126
18810761-3	2008	In this study, La3+ treatment enhanced in vitro osteoblast differentiation as evidenced by promoting alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion, and matrix mineralization.	lanthanum(3+)	15-19	bone gamma-carboxyglutamate protein	Homo sapiens	138-149
18810761-4	2008	The expressions of osteoblast-specific genes of Cbfa-1, osteopontin (OPN), and bone sialoprotein (BSP) were all increased in the presence of La3+, but no change was observed in that of type I collagen (COL-I).	lanthanum(3+)	141-145	RUNX family transcription factor 2	Homo sapiens	48-54
18810761-4	2008	The expressions of osteoblast-specific genes of Cbfa-1, osteopontin (OPN), and bone sialoprotein (BSP) were all increased in the presence of La3+, but no change was observed in that of type I collagen (COL-I).	lanthanum(3+)	141-145	secreted phosphoprotein 1	Homo sapiens	56-67
18810761-4	2008	The expressions of osteoblast-specific genes of Cbfa-1, osteopontin (OPN), and bone sialoprotein (BSP) were all increased in the presence of La3+, but no change was observed in that of type I collagen (COL-I).	lanthanum(3+)	141-145	secreted phosphoprotein 1	Homo sapiens	69-72
18810761-5	2008	Further studies demonstrated that La3+ treatment enhanced phosphorylation of extracellular signal-regulated kinase (ERK).	lanthanum(3+)	34-38	mitogen-activated protein kinase 1	Homo sapiens	77-114
18810761-5	2008	Further studies demonstrated that La3+ treatment enhanced phosphorylation of extracellular signal-regulated kinase (ERK).	lanthanum(3+)	34-38	mitogen-activated protein kinase 1	Homo sapiens	116-119
18810761-6	2008	Inhibition of ERK activation by U0126 suppressed the effects of La3+ on osteoblast activity.	lanthanum(3+)	64-68	mitogen-activated protein kinase 1	Homo sapiens	14-17
18810761-7	2008	Moreover, pretreatment of the cells with pertussis toxin (PTx), a Gi protein inhibitor, suppressed the La3+-enhanced ERK phosphorylation and osteoblast differentiation.	lanthanum(3+)	103-107	mitogen-activated protein kinase 1	Homo sapiens	117-120
18810761-8	2008	These findings suggest that La3+ exposure enhances in vitro osteoblast differentiation and the effect depends on ERK phosphorylation via PTx-sensitive Gi protein signaling.	lanthanum(3+)	28-32	mitogen-activated protein kinase 1	Homo sapiens	113-116
18773883-0	2008	La3+ binds to BiP/GRP78 and induces unfolded protein response in HepG2 cells.	lanthanum(3+)	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	14-17
18773883-0	2008	La3+ binds to BiP/GRP78 and induces unfolded protein response in HepG2 cells.	lanthanum(3+)	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	18-23
18773883-2	2008	Our data showed that La3+ could induce unfolded protein response in HepG2 cells, including a significant increase of BiP/GRP78 level, which is an important ER residential chaperone and an ER stress hallmark, in a concentration and time-dependent manner, UPR transducer IRE1 phosphorylation and splicing activation IRE1 downstream substrate XBP1 mRNA.	lanthanum(3+)	21-25	heat shock protein family A (Hsp70) member 5	Homo sapiens	117-120
18773883-2	2008	Our data showed that La3+ could induce unfolded protein response in HepG2 cells, including a significant increase of BiP/GRP78 level, which is an important ER residential chaperone and an ER stress hallmark, in a concentration and time-dependent manner, UPR transducer IRE1 phosphorylation and splicing activation IRE1 downstream substrate XBP1 mRNA.	lanthanum(3+)	21-25	heat shock protein family A (Hsp70) member 5	Homo sapiens	121-126
18773883-2	2008	Our data showed that La3+ could induce unfolded protein response in HepG2 cells, including a significant increase of BiP/GRP78 level, which is an important ER residential chaperone and an ER stress hallmark, in a concentration and time-dependent manner, UPR transducer IRE1 phosphorylation and splicing activation IRE1 downstream substrate XBP1 mRNA.	lanthanum(3+)	21-25	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	269-273
18773883-2	2008	Our data showed that La3+ could induce unfolded protein response in HepG2 cells, including a significant increase of BiP/GRP78 level, which is an important ER residential chaperone and an ER stress hallmark, in a concentration and time-dependent manner, UPR transducer IRE1 phosphorylation and splicing activation IRE1 downstream substrate XBP1 mRNA.	lanthanum(3+)	21-25	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	314-318
18773883-2	2008	Our data showed that La3+ could induce unfolded protein response in HepG2 cells, including a significant increase of BiP/GRP78 level, which is an important ER residential chaperone and an ER stress hallmark, in a concentration and time-dependent manner, UPR transducer IRE1 phosphorylation and splicing activation IRE1 downstream substrate XBP1 mRNA.	lanthanum(3+)	21-25	X-box binding protein 1	Homo sapiens	340-344
18773883-3	2008	By using La3+-affinity chromatography, the possible cellular target of La3+ leading to UPR events was shown to be the ER residential chaperone BiP/GRP78.	lanthanum(3+)	9-13	heat shock protein family A (Hsp70) member 5	Homo sapiens	143-146
18773883-3	2008	By using La3+-affinity chromatography, the possible cellular target of La3+ leading to UPR events was shown to be the ER residential chaperone BiP/GRP78.	lanthanum(3+)	9-13	heat shock protein family A (Hsp70) member 5	Homo sapiens	147-152
18773883-3	2008	By using La3+-affinity chromatography, the possible cellular target of La3+ leading to UPR events was shown to be the ER residential chaperone BiP/GRP78.	lanthanum(3+)	71-75	heat shock protein family A (Hsp70) member 5	Homo sapiens	143-146
18773883-3	2008	By using La3+-affinity chromatography, the possible cellular target of La3+ leading to UPR events was shown to be the ER residential chaperone BiP/GRP78.	lanthanum(3+)	71-75	heat shock protein family A (Hsp70) member 5	Homo sapiens	147-152
18773883-5	2008	La3+ induced dissociation of the BiP/GRP78-IRE1 complex was in a time and concentration manner.	lanthanum(3+)	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	33-36
18773883-5	2008	La3+ induced dissociation of the BiP/GRP78-IRE1 complex was in a time and concentration manner.	lanthanum(3+)	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	37-42
18773883-5	2008	La3+ induced dissociation of the BiP/GRP78-IRE1 complex was in a time and concentration manner.	lanthanum(3+)	0-4	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	43-47
18715899-8	2008	Synapses deficient in synaptobrevin-2, the major synaptic vesicle soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein in the brain, did not display any rapid release in response to La3+, whereas the slow facilitation of release detected after La3+ removal remained intact.	lanthanum(3+)	277-281	vesicle associated membrane protein 2	Homo sapiens	22-37
18715899-10	2008	Moreover, synapses deficient in synaptotagmin-1 maintained a rapid response to La3+, suggesting that La3+-triggered neurotransmitter release does not require synaptotagmin-1 as a sensor.	lanthanum(3+)	79-83	synaptotagmin 1	Homo sapiens	32-47
18715899-10	2008	Moreover, synapses deficient in synaptotagmin-1 maintained a rapid response to La3+, suggesting that La3+-triggered neurotransmitter release does not require synaptotagmin-1 as a sensor.	lanthanum(3+)	101-105	synaptotagmin 1	Homo sapiens	32-47
18715899-12	2008	For its rapid action, La3+ interacts with a target on the surface membrane, and unlike other forms of release, it triggers strictly synaptobrevin-2-dependent fusion, implying that in central synapses synaptobrevin-2 function is secretagogue specific.	lanthanum(3+)	22-26	vesicle associated membrane protein 2	Homo sapiens	132-147
18715899-12	2008	For its rapid action, La3+ interacts with a target on the surface membrane, and unlike other forms of release, it triggers strictly synaptobrevin-2-dependent fusion, implying that in central synapses synaptobrevin-2 function is secretagogue specific.	lanthanum(3+)	22-26	vesicle associated membrane protein 2	Homo sapiens	200-215
18448590-5	2008	Extracellular divalent ions, Ca2+ and Ba2+, and trivalent cations, La3+, blocked both the wild-type and mutant FXYD2 currents.	lanthanum(3+)	67-71	FXYD domain containing ion transport regulator 2 S homeolog	Xenopus laevis	111-116
18247362-9	2008	La3+ ions potentiated inward TRPC5 currents by promoting a reversible transition from Phase 3 to Phase 2.	lanthanum(3+)	0-4	transient receptor potential cation channel subfamily C member 5	Homo sapiens	29-34
18310228-4	2008	The glucocorticoid/SGK1-induced GNa in single cells discriminated poorly between Na+ and K+ (PNa/PK approximately 0.6), was insensitive to amiloride (1 mM), but was partially blocked by LaCl3 (La3+; 1 mM, approximately 80%), pimozide (0.1 mM, approximately 40%), and dichlorobenzamil (15 microM, approximately 15%).	lanthanum(3+)	193-197	serum/glucocorticoid regulated kinase 1	Homo sapiens	19-23
17936909-2	2008	In the present paper, La(3+) binding to CaM was studied in the presence of the CaM binding peptides, Mastoparan (Mas) and Mas X, using ultrafiltration and titration of fluorescence.	lanthanum(3+)	22-28	calmodulin 1	Homo sapiens	40-43
17936909-2	2008	In the present paper, La(3+) binding to CaM was studied in the presence of the CaM binding peptides, Mastoparan (Mas) and Mas X, using ultrafiltration and titration of fluorescence.	lanthanum(3+)	22-28	calmodulin 1	Homo sapiens	79-82
17936909-3	2008	Ca(2+) binding was used as an analog to understand La(3+) binding in intact CaM and isolated N/C-terminal CaM domain of metal-CaM binary system and metal-CaM-CaMBPs ternary system.	lanthanum(3+)	51-57	calmodulin 1	Homo sapiens	76-79
17936909-3	2008	Ca(2+) binding was used as an analog to understand La(3+) binding in intact CaM and isolated N/C-terminal CaM domain of metal-CaM binary system and metal-CaM-CaMBPs ternary system.	lanthanum(3+)	51-57	calmodulin 1	Homo sapiens	106-109
17936909-3	2008	Ca(2+) binding was used as an analog to understand La(3+) binding in intact CaM and isolated N/C-terminal CaM domain of metal-CaM binary system and metal-CaM-CaMBPs ternary system.	lanthanum(3+)	51-57	calmodulin 1	Homo sapiens	106-109
17936909-3	2008	Ca(2+) binding was used as an analog to understand La(3+) binding in intact CaM and isolated N/C-terminal CaM domain of metal-CaM binary system and metal-CaM-CaMBPs ternary system.	lanthanum(3+)	51-57	calmodulin 1	Homo sapiens	106-109
17936909-5	2008	The metal ions binding affinity to the C-terminal or the N-terminal CaM domain suggested that in the first phase of binding process both Ca(2+) and La(3+) bind to C-terminal of CaM in the presence of Mas/Mas X.	lanthanum(3+)	148-154	calmodulin 1	Homo sapiens	68-71
17936909-5	2008	The metal ions binding affinity to the C-terminal or the N-terminal CaM domain suggested that in the first phase of binding process both Ca(2+) and La(3+) bind to C-terminal of CaM in the presence of Mas/Mas X.	lanthanum(3+)	148-154	calmodulin 1	Homo sapiens	177-180
17936909-6	2008	In the presence of CaM binding peptides, La(3+) binding preference was substantially altered from the metal-CaM binary system where La(3+) slightly preferred binding to the N-terminal sites of CaM.	lanthanum(3+)	41-47	calmodulin 1	Homo sapiens	19-22
17936909-6	2008	In the presence of CaM binding peptides, La(3+) binding preference was substantially altered from the metal-CaM binary system where La(3+) slightly preferred binding to the N-terminal sites of CaM.	lanthanum(3+)	132-138	calmodulin 1	Homo sapiens	19-22
17936909-6	2008	In the presence of CaM binding peptides, La(3+) binding preference was substantially altered from the metal-CaM binary system where La(3+) slightly preferred binding to the N-terminal sites of CaM.	lanthanum(3+)	132-138	calmodulin 1	Homo sapiens	108-111
17936909-6	2008	In the presence of CaM binding peptides, La(3+) binding preference was substantially altered from the metal-CaM binary system where La(3+) slightly preferred binding to the N-terminal sites of CaM.	lanthanum(3+)	132-138	calmodulin 1	Homo sapiens	108-111
17936909-7	2008	Our results will be helpful in understanding La(3+) interactions with CaM in the biological systems.	lanthanum(3+)	45-51	calmodulin 1	Homo sapiens	70-73
17948992-1	2007	An oligometallic template effect was observed on the cis/trans selectivity of a 32-membered macrocyclic tetraoxime in ring-closing olefin metathesis of an acyclic diallyl derivative H4L; the metathesis of heterotrinuclear complex LZn2M (M=Ca2+, La3+) afforded the cis isomer, whereas uncomplexed H4L gave the trans isomer.	lanthanum(3+)	245-249	H4 clustered histone 7	Homo sapiens	182-185
17948992-1	2007	An oligometallic template effect was observed on the cis/trans selectivity of a 32-membered macrocyclic tetraoxime in ring-closing olefin metathesis of an acyclic diallyl derivative H4L; the metathesis of heterotrinuclear complex LZn2M (M=Ca2+, La3+) afforded the cis isomer, whereas uncomplexed H4L gave the trans isomer.	lanthanum(3+)	245-249	H4 clustered histone 7	Homo sapiens	296-299
17661504-4	2007	We study CaM complexes with the physiologically important ions of calcium (Ca2+) and magnesium (Mg2+) and also with two other ions, strontium (Sr2+) and lanthanum (La3+).	lanthanum(3+)	164-168	calmodulin 1	Homo sapiens	9-12
17596195-7	2007	In addition to a previously described block by ruthenium red, we identified the trivalent cations, lanthanum (La(3+)) and gadolinium (Gd(3+)) as potent blockers of TRPV2.	lanthanum(3+)	110-116	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	164-169
17148436-4	2007	The CyaA-mediated [Ca2+]i increase in CD11b+ J774A.1 monocytes was inhibited by extracellular La3+ ions but not by nifedipine, SK&F 96365, flunarizine, 2-aminoethyl diphenylborinate, or thapsigargin, suggesting that influx of Ca2+ into cells was not because of receptor signaling or opening of conventional calcium channels by cAMP.	lanthanum(3+)	94-98	integrin subunit alpha M	Homo sapiens	38-43
17136261-1	2006	Complexation of linear hexaoxime ligand H6L with Zn2+ and Mn+ (= La3+, Ba2+) afforded a tetranuclear single metallohelicate [LZn3M]n+, whose inversion rate can be modulated by the central metal Mn+.	lanthanum(3+)	65-69	H6 family homeobox 2	Homo sapiens	40-43
17194921-0	2006	Effect of lanthanum ions (La3+) on ferritin-regulated antioxidant process under PEG stress.	lanthanum(3+)	26-30	Fer2	Triticum aestivum	35-43
17194921-3	2006	The activities of superoxide dismutase, catalase, ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, glutathione reductase, and peroxidase were also increased after La3+ treatment.	lanthanum(3+)	196-200	POD1	Triticum aestivum	50-70
17194921-3	2006	The activities of superoxide dismutase, catalase, ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, glutathione reductase, and peroxidase were also increased after La3+ treatment.	lanthanum(3+)	196-200	probable glutathione S-transferase DHAR1, cytosolic	Triticum aestivum	76-102
17194921-4	2006	Treatment with La3+ seems to enhance the capacity of the reactive oxygen species scavenging system, affect the Fe2+ and Fe3+ electron-transfer process in ferritin, and restrain the formation of hydroxyl radical (OH.	lanthanum(3+)	15-19	Fer2	Triticum aestivum	154-162
16964983-0	2006	La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells.	lanthanum(3+)	0-6	mitogen-activated protein kinase 1	Mus musculus	15-52
16964983-0	2006	La(3+)-induced extracellular signal-regulated kinase (ERK) signaling via a metal-sensing mechanism linking proliferation and apoptosis in NIH 3T3 cells.	lanthanum(3+)	0-6	mitogen-activated protein kinase 1	Mus musculus	54-57
16964983-1	2006	The effects of La(3+) on the extracellular signal-regulated kinase (ERK) signaling were investigated to explore the mechanism by which La(3+) results in cell proliferation associated with apoptosis in mouse embryo fibroblast NIH 3T3 cells.	lanthanum(3+)	15-21	mitogen-activated protein kinase 1	Mus musculus	68-71
16964983-2	2006	Our data showed that La(3+) ions could induce a pulse of phosphorylation of ERK mainly through an unknown metal-sensing mechanism, which is different from the Ca(2+)-sensing receptor .	lanthanum(3+)	21-27	mitogen-activated protein kinase 1	Mus musculus	76-79
16964983-6	2006	This La(3+)-induced signaling cascade exhibited abnormally sustained c-myc induction and pRb phosphorylation.	lanthanum(3+)	5-11	RB transcriptional corepressor 1	Mus musculus	89-92
16964983-9	2006	Therefore, the experimental results suggested that La(3+) induced cell proliferation and apoptosis compatible to a p53-related mechanism in NIH 3T3 cells via an ERK-signaling cascade induced by a metal-sensing mechanism.	lanthanum(3+)	51-57	transformation related protein 53, pseudogene	Mus musculus	115-118
16964983-9	2006	Therefore, the experimental results suggested that La(3+) induced cell proliferation and apoptosis compatible to a p53-related mechanism in NIH 3T3 cells via an ERK-signaling cascade induced by a metal-sensing mechanism.	lanthanum(3+)	51-57	mitogen-activated protein kinase 1	Mus musculus	161-164
16396924-5	2006	Bath application of flufenamic acid, Gd3+, La3+ and Ca2+ inhibited spontaneous channel activity in outside-out patches with IC50 values of 6.8 microm, 25 nm, 1.5 microm and 0.124 mm, respectively, which are similar values to those against TRPC3 proteins.	lanthanum(3+)	43-47	short transient receptor potential channel 3	Oryctolagus cuniculus	239-244
16502327-3	2006	In the present work, it was found that La3+ could induce rapid extracellular signal-regulated kinase (ERK) phosphorylation in both HeLa cells and NIH 3T3 cells, but different mechanisms were involved.	lanthanum(3+)	39-43	mitogen-activated protein kinase 1	Homo sapiens	63-100
16502327-3	2006	In the present work, it was found that La3+ could induce rapid extracellular signal-regulated kinase (ERK) phosphorylation in both HeLa cells and NIH 3T3 cells, but different mechanisms were involved.	lanthanum(3+)	39-43	mitogen-activated protein kinase 1	Homo sapiens	102-105
16502327-4	2006	At a concentration of 30 microM or higher, La3+ enters the cells and activates ERK through a mechanism involving calmodulin activation inside the cells, which is similar to the action of intracellular Ca2+.	lanthanum(3+)	43-47	mitogen-activated protein kinase 1	Homo sapiens	79-82
16502327-5	2006	However, at lower concentration, free La3+ promoted ERK phosphorylation in NIH 3T3 cells outside the cells through an unknown La3+ sensing mechanism, while Ca2+ exerted much weaker effect.	lanthanum(3+)	38-42	mitogen-activated protein kinase 1	Mus musculus	52-55
15961724-6	2005	By employing GF-109203X (protein kinase C [PKC] inhibitor) and lanthanum (La3+), a nonselective cation channel blocker, we observed that SDHG evoked ASM contractile response via PKC-dependent and PKC-independent (but Ca2+-dependent) pathways.	lanthanum(3+)	74-78	Prkca	Cavia porcellus	178-181
15961724-6	2005	By employing GF-109203X (protein kinase C [PKC] inhibitor) and lanthanum (La3+), a nonselective cation channel blocker, we observed that SDHG evoked ASM contractile response via PKC-dependent and PKC-independent (but Ca2+-dependent) pathways.	lanthanum(3+)	74-78	Prkca	Cavia porcellus	178-181
16099516-10	2005	The lanthanide La3+ fully inhibited the CCE from neonatal mice whereas it weakly blocked the thapsigargin-dependent Ca2+ entry at E13.	lanthanum(3+)	15-19	skull morphology 19	Mus musculus	130-133
15713785-9	2005	The nonselective cation La3+ abolished Mg2+ uptake.	lanthanum(3+)	24-28	mucin 7, secreted	Homo sapiens	39-42
15882573-6	2005	At this stage, the cadherin 23 ectodomain epitope remains on the hair bundle following BAPTA or La(3+) treatment, but is lost following exposure to the protease subtilisin.	lanthanum(3+)	96-102	cadherin-related 23	Rattus norvegicus	19-30
15534878-5	2005	La(3+) caused the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2; while inhibition of ERK phosphorylation by 2"-amino-3"-methoxyflavone (PD98059) suppressed both proliferation and apoptosis induced by La(3+).	lanthanum(3+)	0-6	mitogen-activated protein kinase 3	Mus musculus	37-84
15534878-5	2005	La(3+) caused the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2; while inhibition of ERK phosphorylation by 2"-amino-3"-methoxyflavone (PD98059) suppressed both proliferation and apoptosis induced by La(3+).	lanthanum(3+)	0-6	mitogen-activated protein kinase 1	Mus musculus	76-79
15534878-5	2005	La(3+) caused the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2; while inhibition of ERK phosphorylation by 2"-amino-3"-methoxyflavone (PD98059) suppressed both proliferation and apoptosis induced by La(3+).	lanthanum(3+)	221-227	mitogen-activated protein kinase 1	Mus musculus	76-79
15339793-7	2005	The mitochondrial Ca(2+) uniporter (MCU) played a key role in mitochondrial damage: 1) MCU inhibitors (La(3+), ruthenium red, Ru360) prevented swelling and cytochrome c release; and 2) ruthenium red attenuated Cd(2+) inhibition of PO(4)(3-)-induced swelling.	lanthanum(3+)	103-109	mitochondrial calcium uniporter	Rattus norvegicus	36-39
15339793-7	2005	The mitochondrial Ca(2+) uniporter (MCU) played a key role in mitochondrial damage: 1) MCU inhibitors (La(3+), ruthenium red, Ru360) prevented swelling and cytochrome c release; and 2) ruthenium red attenuated Cd(2+) inhibition of PO(4)(3-)-induced swelling.	lanthanum(3+)	103-109	mitochondrial calcium uniporter	Rattus norvegicus	87-90
15464797-3	2004	Fluoride removal from water using Al3+- and La3+-exchanged zeolite F-9 particles was subsequently investigated to evaluate the fluoride sorption characteristics of the sorbents.	lanthanum(3+)	44-48	coagulation factor IX	Homo sapiens	67-70
15258766-5	2004	Furthermore, in pressurized arteries, the ET-1-induced contraction was also inhibited by La(3+) and streptomycin, but not by nicardipine.	lanthanum(3+)	89-95	endothelin-1	Oryctolagus cuniculus	42-46
15016832-7	2004	Thrombin or thapsigargin also activated La3+-sensitive Ca2+ entry in a PKCalpha-dependent manner.	lanthanum(3+)	40-44	coagulation factor II, thrombin	Homo sapiens	0-8
15016832-7	2004	Thrombin or thapsigargin also activated La3+-sensitive Ca2+ entry in a PKCalpha-dependent manner.	lanthanum(3+)	40-44	protein kinase C alpha	Homo sapiens	71-79
15107577-4	2004	The urotensin II-induced contraction was also partially inhibited by verapamil and La(3+).	lanthanum(3+)	83-89	urotensin 2	Rattus norvegicus	4-16
15005604-0	2004	Binding of La3+ to calmodulin and its effects on the interaction between calmodulin and calmodulin binding peptide, polistes mastoparan.	lanthanum(3+)	11-15	calmodulin 1	Homo sapiens	19-29
15005604-0	2004	Binding of La3+ to calmodulin and its effects on the interaction between calmodulin and calmodulin binding peptide, polistes mastoparan.	lanthanum(3+)	11-15	calmodulin 1	Homo sapiens	73-83
15005604-0	2004	Binding of La3+ to calmodulin and its effects on the interaction between calmodulin and calmodulin binding peptide, polistes mastoparan.	lanthanum(3+)	11-15	calmodulin 1	Homo sapiens	73-83
15005604-1	2004	Binding of La(3+) to calmodulin (CaM) and its effects on the complexes of CaM and CaM-binding peptide, polistes mastoparan (Mas), were investigated by nuclear magnetic resonance (NMR) spectroscopy, fluorescence and circular dichroism spectroscopy, and by the fluorescence stopped-flow method.	lanthanum(3+)	11-17	calmodulin 1	Homo sapiens	21-31
15005604-1	2004	Binding of La(3+) to calmodulin (CaM) and its effects on the complexes of CaM and CaM-binding peptide, polistes mastoparan (Mas), were investigated by nuclear magnetic resonance (NMR) spectroscopy, fluorescence and circular dichroism spectroscopy, and by the fluorescence stopped-flow method.	lanthanum(3+)	11-17	calmodulin 1	Homo sapiens	33-36
15005604-1	2004	Binding of La(3+) to calmodulin (CaM) and its effects on the complexes of CaM and CaM-binding peptide, polistes mastoparan (Mas), were investigated by nuclear magnetic resonance (NMR) spectroscopy, fluorescence and circular dichroism spectroscopy, and by the fluorescence stopped-flow method.	lanthanum(3+)	11-17	calmodulin 1	Homo sapiens	74-77
15005604-8	2004	Fluorescence stopped-flow experiments showed that the dissociation rate of La(3+) from the C-terminal domain of CaM was higher than that from the N-terminal.	lanthanum(3+)	75-81	calmodulin 1	Homo sapiens	112-115
12773311-1	2003	La3+ uptake was measured in fura 2-loaded Chinese hamster ovary cells expressing the bovine cardiac Na+/Ca2+ exchanger (NCX1.1).	lanthanum(3+)	0-4	solute carrier family 8 member A1	Homo sapiens	120-124
12773311-6	2003	La3+ uptake occurred without a lag period in cells expressing a mutant of NCX1.1 that does not exhibit regulatory activation by cytosolic Ca2+.	lanthanum(3+)	0-4	solute carrier family 8 member A1	Homo sapiens	74-78
12773311-9	2003	Thus preloading cells expressing NCX1.1 with a small quantity of La3+ increased the rate of exchange-mediated Ca2+ influx by 20-fold; in contrast, cytosolic La3+ partially inhibited Ca2+ uptake by the regulation-deficient mutant.	lanthanum(3+)	65-69	solute carrier family 8 member A1	Homo sapiens	33-37
12773311-9	2003	Thus preloading cells expressing NCX1.1 with a small quantity of La3+ increased the rate of exchange-mediated Ca2+ influx by 20-fold; in contrast, cytosolic La3+ partially inhibited Ca2+ uptake by the regulation-deficient mutant.	lanthanum(3+)	157-161	solute carrier family 8 member A1	Homo sapiens	33-37
12944501-3	2003	Depletion of internal Ca2+ stores by thapsigargin caused intracellular Ca2+ elevation, which was prevented by SOC channel inhibitors 2-aminoethoxydiphenyl borate (2-APB), SKF96365, and La3+.	lanthanum(3+)	185-189	carbonic anhydrase 2	Homo sapiens	22-25
12944501-3	2003	Depletion of internal Ca2+ stores by thapsigargin caused intracellular Ca2+ elevation, which was prevented by SOC channel inhibitors 2-aminoethoxydiphenyl borate (2-APB), SKF96365, and La3+.	lanthanum(3+)	185-189	carbonic anhydrase 2	Homo sapiens	71-74
12803616-7	2003	Cholera toxin (CTX) partially recovered the inhibition of the above La3+-promoted process by the anti-CaM antibody.	lanthanum(3+)	68-72	calmodulin 1	Homo sapiens	102-105
12803616-5	2003	La3+-CaM complexes (La3+-CaM) increased pollen germination and tube growth more than CaM or La3+ alone.	lanthanum(3+)	0-4	calmodulin 1	Homo sapiens	5-8
12803616-5	2003	La3+-CaM complexes (La3+-CaM) increased pollen germination and tube growth more than CaM or La3+ alone.	lanthanum(3+)	0-4	calmodulin 1	Homo sapiens	25-28
12803616-5	2003	La3+-CaM complexes (La3+-CaM) increased pollen germination and tube growth more than CaM or La3+ alone.	lanthanum(3+)	0-4	calmodulin 1	Homo sapiens	25-28
12803616-8	2003	Concentrations of 10-7 approximately 10-9 m La3+-CaM increased GTPase activity inside plasma membrane vesicles of the pollen tube, but apo-CaM or La3+ alone had no positive effects.	lanthanum(3+)	44-48	calmodulin 1	Homo sapiens	49-52
12803616-9	2003	The results suggest that apoplastic CaM may be involved in the promotion effects of lower concentrations of La3+ on pollen germination and tube growth, and the heterotrimeric G-protein on the plasma membrane may transduce La3+-activated CaM signalling.	lanthanum(3+)	108-112	calmodulin 1	Homo sapiens	36-39
12631560-6	2003	Both NSCC activated by CCh in murine stomach and mTRP5 were inhibited by intracellularly applied anti-G(q/11) antibody, PLC inhibitor U-73122, IICR inhibitor 2-aminoethoxydiphenylborate, and nonspecific cation channel blockers La(3+) and flufenamate.	lanthanum(3+)	227-233	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	49-54
12456670-4	2003	Whole cell currents through TRPC5 were reversibly potentiated by micromolar concentrations of La(3+) or Gd(3+), whereas millimolar concentrations were inhibitory.	lanthanum(3+)	94-100	transient receptor potential cation channel subfamily C member 5	Homo sapiens	28-33
12456670-5	2003	By comparison, TRPC6 was blocked to a similar extent by La(3+) or Gd(3+) at micromolar concentrations and showed no potentiation.	lanthanum(3+)	56-62	transient receptor potential cation channel subfamily C member 6	Homo sapiens	15-20
12648299-5	2003	Nifedipine and La(3+) also inhibited ET-1-induced [Ca(2+)](i) increase by 26% and 91%, respectively.	lanthanum(3+)	15-21	endothelin 1	Bos taurus	37-41
12411513-4	2002	A similar weakly voltage-dependent block was also caused by extracellular Ca(2+) and La(3+) in Kir2.1 WT but not in the E125Q mutant.	lanthanum(3+)	85-91	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	95-101
12384249-10	2002	The fall in TEER from bradykinin was blocked by HOE 140, U73122 and thapsigargin combined with La(3+), and also by aristolochic acid and NDGA, but not indomethacin, calphostin C or L-NAME.	lanthanum(3+)	95-101	kininogen 1	Homo sapiens	22-32
12135702-7	2002	Nifedipine and La(3+) also abolished the 10(-7) M ET-1-induced [Ca(2+)](i) in the first rising peak.	lanthanum(3+)	15-21	endothelin 1	Rattus norvegicus	50-54
12210826-7	2002	The compound SKF96365, which blocks store operated influx of Ca(2+) in human microglia, was ineffective in altering the increase in [Ca(2+)](i), however, La(3+) completely inhibited the Ca(2+) response induced by IFN-gamma.	lanthanum(3+)	154-160	interferon gamma	Homo sapiens	213-222
12114324-6	2002	Ca2+ influx activated by thrombin was blocked by La3+ (1 micromol/L).	lanthanum(3+)	49-53	coagulation factor II	Mus musculus	25-33
12114324-9	2002	In isolated-perfused mouse lungs, the PAR-1 agonist peptide increased microvessel filtration coefficient (K(f,c)), a measure of vascular permeability, by a factor of 2.8 in wt and 1.4 in TRPC4(-/-); La3+ (1 micromol/L) addition to wt lung perfusate reduced the agonist effect to that observed in TRPC4(-/-).	lanthanum(3+)	199-203	coagulation factor II (thrombin) receptor	Mus musculus	38-43
12060262-1	2002	Recently, we have demonstrated that treatment of tobacco (Nicotiana tabacum) cell suspension culture with various salts result in an immediate burst of superoxide production via activation of NADPH oxidase by ions of alkali metals (Li+, Na+, K+), alkali earth metals (Mg2+, Ca2+) or lanthanides (La3+, Gd3+).	lanthanum(3+)	296-300	respiratory burst oxidase homolog protein A-like	Nicotiana tabacum	192-205
11880034-1	2002	Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry was used to investigate Ca(2+), Mg(2+), and La(3+) binding to bovine bone osteocalcin (OCN).	lanthanum(3+)	128-134	bone gamma-carboxyglutamate protein	Bos taurus	158-169
11880034-1	2002	Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry was used to investigate Ca(2+), Mg(2+), and La(3+) binding to bovine bone osteocalcin (OCN).	lanthanum(3+)	128-134	bone gamma-carboxyglutamate protein	Bos taurus	171-174
11880034-6	2002	La(3+) bound to a lesser extent than either Ca(2+) or Mg(2+) to OCN and, like Mg(2+), did not influence dimerization.	lanthanum(3+)	0-6	bone gamma-carboxyglutamate protein	Bos taurus	64-67
11481220-5	2001	Antisense oligonucleotides stably decreased Trp1 at concentrations ranging from 10 to 300 nM, for up to 72 h. Thapsigargin increased global cytosolic Ca2+ and activated a I(SOC), which was small (-35 pA @ -80 mV), reversed near +40 mV, inhibited by 50 microM La3+, and exhibited anomalous mole fraction dependence.	lanthanum(3+)	259-263	transient receptor potential cation channel subfamily C member 1	Homo sapiens	44-48
11350748-7	2001	Store-operated Ca2+ influx was greater at negative potentials and was blocked by La(3+).	lanthanum(3+)	81-87	carbonic anhydrase 2	Homo sapiens	15-18
11159002-5	2001	La3+ reduced both the thrombin-induced decrease in endothelial monolayer electrical resistance and the increase in 125I-albumin permeability in HUVECs.	lanthanum(3+)	0-4	coagulation factor II, thrombin	Homo sapiens	22-30
11252306-4	2001	This channel was inhibited by anti-polycystin-2 antibody, Ca2+, La3+, Gd3+, and the diuretic amiloride.	lanthanum(3+)	64-68	polycystin 2, transient receptor potential cation channel	Homo sapiens	35-47
10936199-5	2000	La(3+) enhanced secretion evoked by other agents that mobilize intracellular Ca(2+) stores (angiotensin II, bradykinin, caffeine, and thapsigargin), but not that due to passive depolarization with 20 mM K(+).	lanthanum(3+)	0-6	kininogen 1	Bos taurus	108-118
10898527-4	2000	Previous studies have reported that IKr of myocytes, and HERG channels heterologously expressed in Xenopus oocytes, are reduced by external Co2+ and La3+.	lanthanum(3+)	149-153	potassium voltage-gated channel subfamily H member 2	Homo sapiens	57-61
10898527-5	2000	We have reinvestigated the "blocking" effect of Co2+ and La3+ on HERG channels expressed in Xenopus oocytes.	lanthanum(3+)	57-61	potassium voltage-gated channel subfamily H member 2	Homo sapiens	65-69
10898527-9	2000	Co2+ and La3+ accelerated the rate of deactivation, decreased the rate of current activation, and shifted the half-point of the HERG channel activation curve by +53 and +65 mV, respectively.	lanthanum(3+)	9-13	potassium voltage-gated channel subfamily H member 2	Homo sapiens	128-132
10890529-8	2000	The expression of the ccd-1 mRNA was induced by treatment with A23187, and the induction was suppressed by La(3+) or 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid (BAPTA).	lanthanum(3+)	107-113	calcium-binding protein PBP1	Triticum aestivum	22-27
10732214-0	2000	[Effect of neuraminidase and proteolytic enzymes on electrophoretic mobility of erythrocytes and their aggregation induced by La(3+)].	lanthanum(3+)	126-132	neuraminidase 1	Homo sapiens	11-24
10858625-7	2000	The removal of extracellular Ca(2+) or stimulation in the presence of Ni(2+) (2mM) or La(3+) (100 microM) blocked the RANTES-elicited [Ca(2+)](i) increase.	lanthanum(3+)	86-92	C-C motif chemokine ligand 5	Homo sapiens	118-124
10600781-3	1999	The HERG K(+) channel blockers E-4031 (1 microM), cisapride (1 microM), and La(3+) (100 microM) strongly inhibited these currents as did millimolar concentrations of Ba(2+).	lanthanum(3+)	76-82	potassium voltage-gated channel subfamily H member 2	Homo sapiens	4-8
10527417-5	1999	BAPTA and a calcium channel blocker, La3+, inhibited the elicitor-induced expression of the WCK-1 mRNA.	lanthanum(3+)	37-41	mitogen-activated protein kinase 5	Triticum aestivum	92-97
10377243-4	1999	The increase in TrpL channel activity was blocked by concentrations of La3+ that completely inhibited endogenous capacitative Ca2+ entry (CCE), but have no effect on TrpL, suggesting that TrpL exhibits trans-stimulation by cation entry via CCE.	lanthanum(3+)	71-75	transient receptor potential-like	Drosophila melanogaster	16-20
10398759-3	1999	The endogenous kinase is identified as casein kinase II (CK II) based on its ability to use GTP as effectively as ATP, and its inhibition by La3+.	lanthanum(3+)	141-145	casein kinase 2 alpha 1	Homo sapiens	39-55
10398759-3	1999	The endogenous kinase is identified as casein kinase II (CK II) based on its ability to use GTP as effectively as ATP, and its inhibition by La3+.	lanthanum(3+)	141-145	casein kinase 2 alpha 1	Homo sapiens	57-62
10549843-8	1999	Also, sustained arginine vasopressin-mediated increases in [Ca2+]i and inward current were attenuated by Ca2+-free or La3+-supplemented perfusate but not by nifedipine (n=5).	lanthanum(3+)	118-122	arginine vasopressin	Rattus norvegicus	25-36
10533589-9	1999	The tBHP-induced currents resembled Trp-related currents in terms of cation selectivity, La3+ sensitivity and lack of voltage dependence.	lanthanum(3+)	89-93	transient receptor potential	Drosophila melanogaster	36-39
10227849-5	1999	In the absence of external Ca2+ and at rather high concentrations, La3+ and Gd3+ blocked INSC.	lanthanum(3+)	67-71	INSC spindle orientation adaptor protein	Homo sapiens	89-93
10082271-3	1999	La3+ significantly potentiated the action of GABA in the molecular layer of the alpha6-/- mice, but not in that of the wildtype mice.	lanthanum(3+)	0-4	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	80-89
9929559-5	1999	The effects of Cd2+ on the twitch, tetanus and action potential were mimicked by Zn2+, while La3+ and Co2+ at 3 mM - or Mg2+ and Ca2+ at 30 mM - depressed peak twitch and tetanic tension, but did not potentiate twitches.	lanthanum(3+)	93-97	Cd2 molecule	Rattus norvegicus	15-18
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	lanthanum(3+)	188-192	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	45-50
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	lanthanum(3+)	188-192	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	148-175
9688596-4	1998	Ni2+ and Co2+ were most efficient in such discrimination of NCX isoforms, although their inhibitory potencies were less than those of La3+ and Cd2+.	lanthanum(3+)	134-138	T cell leukemia homeobox 2	Homo sapiens	60-63
9688612-3	1998	Removal of extracellular Ca2+ and addition of La3+ or Gd3+, but not Zn2+, inhibited the increases in KCa current and [Ca2+]i.	lanthanum(3+)	46-50	casein kappa	Homo sapiens	101-104
9512497-6	1998	Whole-cell membrane currents recorded in TrpC1-expressing cells increased as a function of post-infection time and were (1) inwardly rectifying in symmetrical sodium gluconate solutions, (2) non-selective with respect to Na+, Ca2+ and Ba2+, and (3) blocked by La3+.	lanthanum(3+)	260-264	transient receptor potential cation channel subfamily C member 1	Homo sapiens	41-46
9430719-2	1998	We describe the isolation of two yeast genes (ALR1 and ALR2) which confer increased tolerance to Al3+ and Ga3+ ions when overexpressed while increasing strain sensitivity to Zn2+, Mn2+, Ni2+, Cu2+, Ca2+, and La3+ ions.	lanthanum(3+)	208-212	Mg(2+) transporter ALR1	Saccharomyces cerevisiae S288C	46-50
9430719-2	1998	We describe the isolation of two yeast genes (ALR1 and ALR2) which confer increased tolerance to Al3+ and Ga3+ ions when overexpressed while increasing strain sensitivity to Zn2+, Mn2+, Ni2+, Cu2+, Ca2+, and La3+ ions.	lanthanum(3+)	208-212	putative Mg(2+) transporter ALR2	Saccharomyces cerevisiae S288C	55-59
9417057-11	1998	The increased cation entry in Trp3 cells was blocked by high concentrations of SKF 96365, verapamil, La3+, Ni2+, and Gd3+.	lanthanum(3+)	101-105	transient receptor potential cation channel subfamily C member 3	Homo sapiens	30-34
9390185-2	1997	Here, we study the accessibility of the fluorescein covalently attached to the Lys515 at the nucleotide binding domain of the ATPase to the small collisional quencher iodide at pH 6 and 8, as well as the effect of ligand binding (La3+, La(3+)-nucleotide, and Ca2+).	lanthanum(3+)	230-234	dynein axonemal heavy chain 8	Homo sapiens	126-132
9390185-6	1997	Taken together, these findings show the presence of structural flexibility in the FITC binding site and suggest a structural modulation of the Ca(2+)-ATPase nucleotide binding domain by pH and La3+ binding through long-range link-age mechanisms.	lanthanum(3+)	193-197	dynein axonemal heavy chain 8	Homo sapiens	150-156
9406818-4	1997	Removal of extracellular Ca2+ or addition of Ca2+-entry blocker La3+ or SK&F 96365 inhibited Ca(i) oscillations, suggesting that Ca(i) oscillations in ras-transfected HaCaT keratinocytes were dependent on Ca2+ influx across the plasma membrane.	lanthanum(3+)	64-68	carbonic anhydrase 1	Homo sapiens	97-102
9406818-4	1997	Removal of extracellular Ca2+ or addition of Ca2+-entry blocker La3+ or SK&F 96365 inhibited Ca(i) oscillations, suggesting that Ca(i) oscillations in ras-transfected HaCaT keratinocytes were dependent on Ca2+ influx across the plasma membrane.	lanthanum(3+)	64-68	carbonic anhydrase 1	Homo sapiens	133-138
9368034-8	1997	The mTrp6-mediated increase in Ca2+ entry activity was blocked by SKF-96365 and La3+.	lanthanum(3+)	80-84	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	4-9
9213226-10	1997	Concomitant with a decrease in IGFBP-3 and IGFBP-5 release, La3+ caused an increase in [125I]-IGF-I binding to cell-associated IGFBPs and type I IGF receptors.	lanthanum(3+)	60-64	insulin like growth factor 1	Homo sapiens	94-99
9213226-10	1997	Concomitant with a decrease in IGFBP-3 and IGFBP-5 release, La3+ caused an increase in [125I]-IGF-I binding to cell-associated IGFBPs and type I IGF receptors.	lanthanum(3+)	60-64	insulin like growth factor binding protein 2	Homo sapiens	127-133
9231716-4	1997	The low [Ca2+]e-induced response is also blocked by replacement of extracellular Ca2+ with Ba2+, Zn2+, or Ni2+, and by 100 microM La3+.	lanthanum(3+)	130-134	carbonic anhydrase 2	Homo sapiens	9-12
9227424-2	1997	We now report that these effects are largely mediated by a 4- to 10-fold increased rate of La(3+)-sensitive 45Ca extrusion, which is associated with 2- to 4-fold increased levels of plasma membrane Ca(2+)-ATPase 1 (PMCA1) mRNA and protein.	lanthanum(3+)	91-97	ATPase plasma membrane Ca2+ transporting 1	Homo sapiens	182-213
9227424-2	1997	We now report that these effects are largely mediated by a 4- to 10-fold increased rate of La(3+)-sensitive 45Ca extrusion, which is associated with 2- to 4-fold increased levels of plasma membrane Ca(2+)-ATPase 1 (PMCA1) mRNA and protein.	lanthanum(3+)	91-97	ATPase plasma membrane Ca2+ transporting 1	Homo sapiens	215-220
9105729-8	1997	Pretreatment of the cells with octanol to block gap junctions, or with EGTA or La3+ to inhibit Ca2+ influx, abolished the synchronization induced by bradykinin or thrombin.	lanthanum(3+)	79-83	kininogen 1	Canis lupus familiaris	149-159
9138723-1	1997	The effect of the trivalent cation lanthanum (La3+) on voltage-dependent gating of a cloned mammalian neuronal Kv1.1 potassium channel was studied under whole-cell voltage-clamp conditions in oocytes of Xenopus laevis.	lanthanum(3+)	46-50	potassium voltage-gated channel subfamily A member 1	Homo sapiens	111-116
9049606-4	1997	La3+ and Cd2+ (1 mM) almost completely abolished the vasopressin or endothelin-induced non-selective cation current; however, nifedipine (10 microM) failed to inhibit it significantly.	lanthanum(3+)	0-4	arginine vasopressin	Rattus norvegicus	53-64
9038807-6	1997	The single channels 1) were never observed in Sf9 cells infected with recombinant baculovirus containing the B2 bradykinin receptor cDNA or in noninfected Sf9 cells; 2) appear at the same time postinfection as the Trpl whole cell current; 3) were nonselective with respect to Na+, Ca2+, and Ba2+; 4) were blocked by 1-2 mM La3+ and Gd3+ (but not 10 microM); and 5) were blocked by 4-8 mM Mg2+.	lanthanum(3+)	323-327	transient receptor potential-like	Drosophila melanogaster	214-218
9010750-3	1996	The half-life of ApA hydrolysis by the dinuclear La3+ complex (1 mM) is 350 s, whereas that by the free La3+ ion (1 mM) is 23,000 s at pH 7.2 and 50 degrees C. The dinuclear La3+ complex is promising as a catalytic center of artificial nucleases.	lanthanum(3+)	49-53	glutamyl aminopeptidase	Homo sapiens	17-20
9010750-3	1996	The half-life of ApA hydrolysis by the dinuclear La3+ complex (1 mM) is 350 s, whereas that by the free La3+ ion (1 mM) is 23,000 s at pH 7.2 and 50 degrees C. The dinuclear La3+ complex is promising as a catalytic center of artificial nucleases.	lanthanum(3+)	104-108	glutamyl aminopeptidase	Homo sapiens	17-20
9010750-3	1996	The half-life of ApA hydrolysis by the dinuclear La3+ complex (1 mM) is 350 s, whereas that by the free La3+ ion (1 mM) is 23,000 s at pH 7.2 and 50 degrees C. The dinuclear La3+ complex is promising as a catalytic center of artificial nucleases.	lanthanum(3+)	104-108	glutamyl aminopeptidase	Homo sapiens	17-20
8765099-11	1996	Like the endogenous phosphorylation of the 150/160-kDa proteins in SR. the phosphorylation of the purified proteins by CK II was inhibited by La3+ (Cl50 = 4 microM) and hemin.	lanthanum(3+)	142-146	casein kinase 2 alpha 1	Homo sapiens	119-124
8760362-5	1996	Furthermore, in comparison with results obtained following inhibition of the plasma membrane Ca(2+)-ATPase by La3+ (2 mM), it may be shown that slowly unloading the intracellular Ca2+ stores using thapsigargin does not normally cause a massive, cytotoxic, increase in the cytosolic Ca2+ concentration, because Ca2+ is rapidly extruded from the cell across the plasma membrane.	lanthanum(3+)	110-114	dynein, axonemal, heavy chain 8	Mus musculus	100-106
9019533-9	1996	Raising external pH or application of extracellular Eosin of La3+ prolonged slow tail currents, indicating a contribution of plasma membrane Ca(2+)-ATPase to Ca2+ clearance.	lanthanum(3+)	61-65	carbonic anhydrase 2	Rattus norvegicus	158-161
8732499-12	1996	La3+ (1 mM), Cd2+ (1 mM) completely abolished the vasopressin-induced (IN.S.	lanthanum(3+)	0-4	arginine vasopressin	Homo sapiens	50-61
8604023-7	1996	Preincubation of the cells with ethanol and/or La3+ inhibited IL-8-induced degranulations, suggesting that activation of phospholipase D and increase of [Ca2+]i were important for this response.	lanthanum(3+)	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8611174-0	1996	Submicromolar La3+ concentrations block the calcium release-activated channel, and impair CD69 and CD25 expression in CD3- or thapsigargin-activated Jurkat cells.	lanthanum(3+)	14-18	CD69 molecule	Homo sapiens	90-94
8611174-0	1996	Submicromolar La3+ concentrations block the calcium release-activated channel, and impair CD69 and CD25 expression in CD3- or thapsigargin-activated Jurkat cells.	lanthanum(3+)	14-18	interleukin 2 receptor subunit alpha	Homo sapiens	99-103
8592135-2	1996	Pb2+, La3+, Cd2+, Sr2+, and Ba2+ activated NE secretion accompanied by the release of intragranular dopamine beta-hydroxylase but not cytosolic lactate dehydrogenase, indicating the activation of the mechanism of exocytosis.	lanthanum(3+)	6-10	dopamine beta-hydroxylase	Bos taurus	100-125
8745276-23	1996	The divalent and trivalent cations Cd2+, Co2+, Ni2+, Zn2+ and La3+ shifted the activation of INa to more positive potentials and decreased the maximal conductance in a dose-dependent manner.	lanthanum(3+)	62-66	internexin neuronal intermediate filament protein, alpha	Mus musculus	93-96
8745276-24	1996	The apparent Kd values for blockade of the INa by Cd2+, Co2+, Ni2+, Zn2+ and La3+ were 430, 3500, 1900, 83 and 202 microM, respectively.	lanthanum(3+)	77-81	internexin neuronal intermediate filament protein, alpha	Mus musculus	43-46
8847629-11	1995	In the presence of La3+, the caffeine response in the guinea-pig ureter and carbachol response in the rat ureter, elicited in Ca(2+)-free solutions, were always increased and prolonged and could be repeatedly evoked, suggesting similarity in Ca2+ uptake behaviour of the store in both species.	lanthanum(3+)	19-23	carbonic anhydrase 2	Rattus norvegicus	242-245
7669029-5	1995	The IIB vWF-evoked (3 micrograms/ml) cytosolic Ca2+ increase was negligibly affected by ADP scavengers or protein kinase C inhibitors; it was drastically reduced by EGTA, La3+, Ni2+ or acetylsalicylate and abolished by the phospholipase A2 inhibitors ONO-RS-082 or oleolyloxyethyl-phosphocholine.	lanthanum(3+)	171-175	von Willebrand factor	Homo sapiens	8-11
7542927-7	1995	Tm3+, Gd3+, Eu3+, Nd3+ and La3+ each inhibited vasopressin-stimulated Ca2+ and Mn2+ inflow but had no effect on Ca2+ inflow in the absence of an agonist, or on vasopressin-stimulated release of Ca2+ from intracellular stores.	lanthanum(3+)	27-31	arginine vasopressin	Homo sapiens	47-58
8521458-8	1995	However, the effects of La3+, nifedipine and KCl-induced depolarization on the PAF-induced [Ca2+]i increase suggest a minor participation of these voltage-gated Ca2+ channels in the response to PAF.	lanthanum(3+)	24-28	patchy fur	Mus musculus	79-82
7552284-1	1995	An antibody directed against the lumenal NH2-terminus of synaptotagmin II was used to examine the distribution of this vesicular protein either after spontaneous acetylcholine release or after sustained release induced by La3+ or alpha-latrotoxin, in conditions that prevent endocytosis.	lanthanum(3+)	222-226	synaptotagmin II	Mus musculus	57-73
7565458-6	1995	Pretreatment with La3+, nifedipine or pertussis toxin reduced both the frequency and amplitude of the PTH response in S phase to values comparable to those observed in cells in G1 phase.	lanthanum(3+)	18-22	parathyroid hormone	Rattus norvegicus	102-105
7983017-5	1994	The Ca2+ clearing response to TRH was not prevented by thapsigargin, Ca2+ ionophores, nimodipine, or replacement of extracellular Na+ but was inhibited by La3+.	lanthanum(3+)	155-159	thyrotropin releasing hormone	Rattus norvegicus	30-33
7983017-6	1994	La3+ also increased the duration of the TRH-evoked [Ca2+]i transient.	lanthanum(3+)	0-4	thyrotropin releasing hormone	Rattus norvegicus	40-43
7708469-7	1994	Inward currents evoked in Ca2+ were inhibited by other cations with the following order of potency: La3+ > Cd2+ > Co2+ approximately Ni2+ approximately Mn2+.	lanthanum(3+)	100-104	carbonic anhydrase 2	Homo sapiens	26-29
7925936-2	1994	In cells from the avian nasal gland, a model exocrine cell, we show that inhibition of Ca2+ entry by La3+, SK&F 96365, or by membrane depolarization, rapidly blocks [Ca2+]i oscillations but does so without detectable depletion of agonist-sensitive Ca2+ stores.	lanthanum(3+)	101-105	carbonic anhydrase 2	Homo sapiens	87-90
7925936-2	1994	In cells from the avian nasal gland, a model exocrine cell, we show that inhibition of Ca2+ entry by La3+, SK&F 96365, or by membrane depolarization, rapidly blocks [Ca2+]i oscillations but does so without detectable depletion of agonist-sensitive Ca2+ stores.	lanthanum(3+)	101-105	carbonic anhydrase 2	Homo sapiens	170-173
7925936-2	1994	In cells from the avian nasal gland, a model exocrine cell, we show that inhibition of Ca2+ entry by La3+, SK&F 96365, or by membrane depolarization, rapidly blocks [Ca2+]i oscillations but does so without detectable depletion of agonist-sensitive Ca2+ stores.	lanthanum(3+)	101-105	carbonic anhydrase 2	Homo sapiens	170-173
8093098-5	1994	Non-selective calcium channel blockers such as econazole and La3+ strongly inhibited ET-1-activated migration but had little effect on fMLP-activated migration, underlining the importance of Ca2+ influx for ET-1-activated migration.	lanthanum(3+)	61-65	endothelin-1	Oryctolagus cuniculus	85-89
8093098-5	1994	Non-selective calcium channel blockers such as econazole and La3+ strongly inhibited ET-1-activated migration but had little effect on fMLP-activated migration, underlining the importance of Ca2+ influx for ET-1-activated migration.	lanthanum(3+)	61-65	endothelin-1	Oryctolagus cuniculus	207-211
7516710-3	1994	Ca2+ influx was slightly inhibited by 5 microM Ruthenium red and completely blocked by La3+ with a half-maximal inhibition attained at 50 microM.	lanthanum(3+)	87-91	carbonic anhydrase 2	Homo sapiens	0-3
8193200-3	1994	It was concluded from the evidence obtained that relaxation of the smooth muscle contracture is controlled by the stimulated temperature increase and by Na(+)-independent trans-sarcolemma release of Ca2+ from the myocytes sensitive to La3+ effect.	lanthanum(3+)	235-239	carbonic anhydrase 2	Homo sapiens	199-202
7516040-7	1994	The rank order of potency of inorganic blockers on the vasopressin-induced inward current was Gd3+ > La3+ > Cd2+.	lanthanum(3+)	104-108	arginine vasopressin	Rattus norvegicus	55-66
8293807-6	1994	La3+ and Ce3+ elicited transient [Ca2+]i peaks independent of external Ca2+, but no oscillations.	lanthanum(3+)	0-4	carbonic anhydrase 2	Homo sapiens	34-37
8275927-5	1994	Pretreatment with either La3+, nifedipine, or pertussis toxin reduced both frequency and amplitude of PTH response in S phase to levels close to G1 phase, whereas there was no significant difference in inositol trisphosphate generated by PTH stimulation in either phase.	lanthanum(3+)	25-29	parathyroid hormone	Rattus norvegicus	102-105
8146016-0	1994	Species variants of the IsK protein: differences in kinetics, voltage dependence, and La3+ block of the currents expressed in Xenopus oocytes.	lanthanum(3+)	86-90	potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog	Xenopus laevis	24-27
8146016-7	1994	The human and the rodent forms of IsK were also differentially affected by external La3+.	lanthanum(3+)	84-88	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	34-37
8240277-4	1993	The C5a-stimulated influx of 45Ca2+ into U937 cells is inhibited by a series of metal ions (Zn2+ > Co2+ > Mn2+ > Sr2+ approximately equal to Ni2+ > La3+).	lanthanum(3+)	160-164	complement C5a receptor 1	Homo sapiens	4-7
8404642-6	1993	The CCK-8-triggered [Ca2+]i transient was not affected by incubating the cells in Ca(2+)-free medium containing 2 mM EGTA or by pretreating the cells with a Ca2+ channel blocker, such as La3+ (1 mM) or D600 (100 microM).	lanthanum(3+)	187-191	cholecystokinin	Gallus gallus	4-7
8227970-6	1993	The stimulatory effect of VIP was correlated with baseline [Ca2+]i in these cells, was attenuated in the presence of La3+ (25 microM), but was unaffected by cell depolarization (126 mM KCl).	lanthanum(3+)	117-121	vasoactive intestinal peptide	Homo sapiens	26-29
8476011-10	1993	The increase in var(s)p was presumed to reflect La(3+)-induced release of Ca2+ from intracellular organelles.	lanthanum(3+)	48-54	carbonic anhydrase 2	Homo sapiens	74-77
1279483-1	1992	The effect of lanthanum ion (La3+) on gamma-aminobutyric acid (GABA)-mediated Cl- currents was examined in the alpha 1 beta 2 or alpha 1 beta 2 gamma 2 subtype of GABAA receptors expressed in a human kidney cell line (A293), using a whole-cell configuration of patch-clamp techniques.	lanthanum(3+)	29-33	adrenoceptor alpha 1D	Homo sapiens	111-118
1279483-1	1992	The effect of lanthanum ion (La3+) on gamma-aminobutyric acid (GABA)-mediated Cl- currents was examined in the alpha 1 beta 2 or alpha 1 beta 2 gamma 2 subtype of GABAA receptors expressed in a human kidney cell line (A293), using a whole-cell configuration of patch-clamp techniques.	lanthanum(3+)	29-33	adrenoceptor alpha 1D	Homo sapiens	129-151
1279483-2	1992	La3+ dose-dependently stimulated the Cl- currents in the alpha 1 beta 2 gamma 2 subtype with an EC50 of 21.3 +/- 3.5 microM with a maximal potentiation of 240 +/- 16% as normalized to the GABA response at 5 microM.	lanthanum(3+)	0-4	adrenoceptor alpha 1D	Homo sapiens	57-79
1279483-3	1992	In the alpha 1 beta 2 subtype, however, the ion marginally potentiated GABA response, a maximal stimulation being less than 70% with an EC50 for La3+ near 200 microM.	lanthanum(3+)	145-149	adrenoceptor alpha 1D	Homo sapiens	7-14
1279483-4	1992	The stimulation of GABA response by La3+ in the alpha 1 beta 2 gamma 2 subtype was due to a decrease in the half maximal concentration for GABA and was more pronounced at the negative membrane potentials.	lanthanum(3+)	36-40	adrenoceptor alpha 1D	Homo sapiens	48-70
1279483-5	1992	This selectivity of La3+ toward the subtypes of GABAA receptors contrasts to that of Zn2+ which inhibits the currents in the alpha 1 beta 2, but not in the alpha 1 beta 2 gamma 2 subtype (Neuron, 5: (1990) 781-788).	lanthanum(3+)	20-24	adrenoceptor alpha 1D	Homo sapiens	125-132
1335503-10	1992	Cd2+, Zn2+ and La3+ produced block of INa at low concentrations that was nearly voltage independent with z" < or = 0.13.	lanthanum(3+)	15-19	internexin neuronal intermediate filament protein alpha	Canis lupus familiaris	38-41
1321817-5	1992	High concentrations of La3+ (2 mM) caused an increase in the response to Tg, suggesting that membrane ATPase exerts a major Cai lowering effect.	lanthanum(3+)	23-27	carbonic anhydrase 1	Homo sapiens	124-127
1318033-9	1992	Bradykinin-stimulated Ca2+ influx was increased at alkaline extracellular pH (pHo), and was inhibited by extracellular La3+, by depolarization of the membrane, and by the novel Ca(2+)-influx blocker 1-(beta-[3-(4-methoxyphenyl)propoxy]-4- methoxyphenethyl)-1H-imidazole hydrochloride (SKF 96365).	lanthanum(3+)	119-123	kininogen 1	Homo sapiens	0-10
1504812-2	1992	The inhibitory action was in the order of La3+ much greater than Cd2+ much greater than Ni2+ greater than Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine greater than omega-conotoxin greater than methoxyverapamil = diltiazem much greater than amiloride for organic ones.	lanthanum(3+)	42-46	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	125-128
1331428-4	1992	In all cells superfused with Na(+)- and K(+)-free external solution containing 10 mM-Ca2+ and 10(-5) M-La3+, a transient inward Ca2+ current was evoked by a step depolarization to potentials more positive than about -50 mV from a holding potential (VH) of -100 mV.	lanthanum(3+)	103-107	carbonic anhydrase 2	Rattus norvegicus	128-131
1575695-8	1992	La3+ and Ni2+ blocked the quenching stimulated by TRH.	lanthanum(3+)	0-4	thyrotropin releasing hormone	Rattus norvegicus	50-53
1312133-7	1992	Inorganic Ca2+ channel blockers Cd2+, La3+, and Mn2+ at 1 mM inhibited both responses induced by ET.	lanthanum(3+)	38-42	endothelin 1	Rattus norvegicus	97-99
2070890-5	1991	La3+ reduced NaF-or CCK-stimulated maximal pepsinogen secretion to 57.0 +/- 2.5% and 73.1 +/- 3.1% of control, respectively.	lanthanum(3+)	0-4	cholecystokinin	Homo sapiens	20-23
2001251-6	1991	A small Ca2+ transient still remains under experimental conditions designed to prevent Ca2+ influx from external medium (low-Ca2+ high-Mg2+ medium containing La3+) and after depletion of the sarcoplasmic-reticulum Ca2+ load with caffeine.	lanthanum(3+)	158-162	carbonic anhydrase 2	Rattus norvegicus	8-11
2174439-4	1990	La3+ blocks endonexin II channels, as it does synexin (annexin VII) and other types of Ca2+ channels.	lanthanum(3+)	0-4	annexin A5	Homo sapiens	12-24
2174439-4	1990	La3+ blocks endonexin II channels, as it does synexin (annexin VII) and other types of Ca2+ channels.	lanthanum(3+)	0-4	annexin A7	Homo sapiens	46-53
2174439-4	1990	La3+ blocks endonexin II channels, as it does synexin (annexin VII) and other types of Ca2+ channels.	lanthanum(3+)	0-4	annexin A7	Homo sapiens	55-66
2280902-3	1990	Alkaline metals, barium (Ba2+), strontium (Sr2+) and other metal cations, manganese (Mn2+) or lanthanum (La3+), support BK-induced [3H]noradrenaline ([3H]NA) release.	lanthanum(3+)	105-109	kininogen 1	Homo sapiens	120-122
2115432-5	1990	PTH release was inhibited by maximal concentrations of La3+ to a greater extent than by Ca2+: 93% inhibition by La3+ vs. 40% by Ca2+.	lanthanum(3+)	55-59	parathyroid hormone	Bos taurus	0-3
2115432-5	1990	PTH release was inhibited by maximal concentrations of La3+ to a greater extent than by Ca2+: 93% inhibition by La3+ vs. 40% by Ca2+.	lanthanum(3+)	112-116	parathyroid hormone	Bos taurus	0-3
2115432-12	1990	In summary: 1) La3+, which blocks Ca2+ channels and does not cross cell membranes, effects a greater inhibition of PTH release than Ca2+; 2) La3+, like Ca2+, overrides the effect of Ca2+ channel antagonist (-)202-791; and 3) La3+, unlike Ca2+, inhibits PTH release by a mechanism that is independent of a pertussis toxin-sensitive G-protein.	lanthanum(3+)	15-19	parathyroid hormone	Bos taurus	115-118
2115432-12	1990	In summary: 1) La3+, which blocks Ca2+ channels and does not cross cell membranes, effects a greater inhibition of PTH release than Ca2+; 2) La3+, like Ca2+, overrides the effect of Ca2+ channel antagonist (-)202-791; and 3) La3+, unlike Ca2+, inhibits PTH release by a mechanism that is independent of a pertussis toxin-sensitive G-protein.	lanthanum(3+)	15-19	parathyroid hormone	Bos taurus	253-256
2115432-12	1990	In summary: 1) La3+, which blocks Ca2+ channels and does not cross cell membranes, effects a greater inhibition of PTH release than Ca2+; 2) La3+, like Ca2+, overrides the effect of Ca2+ channel antagonist (-)202-791; and 3) La3+, unlike Ca2+, inhibits PTH release by a mechanism that is independent of a pertussis toxin-sensitive G-protein.	lanthanum(3+)	141-145	parathyroid hormone	Bos taurus	115-118
2115432-12	1990	In summary: 1) La3+, which blocks Ca2+ channels and does not cross cell membranes, effects a greater inhibition of PTH release than Ca2+; 2) La3+, like Ca2+, overrides the effect of Ca2+ channel antagonist (-)202-791; and 3) La3+, unlike Ca2+, inhibits PTH release by a mechanism that is independent of a pertussis toxin-sensitive G-protein.	lanthanum(3+)	141-145	parathyroid hormone	Bos taurus	115-118
2190805-7	1990	Recent studies with rat hepatocytes show that ruthenium red (RR) and La3+, which block Ca2+ translocation through the mitochondrial uniport, can prevent malondialdehyde (MDA) formation, reduced glutathione (GSH), and protein-SH loss, Vit.	lanthanum(3+)	69-73	vitrin	Rattus norvegicus	234-237
1689544-7	1990	After depletion of the intracellular pool by stimulation in Ca2(+)-free medium, removal of the agonist and readmission of Ca2+ resulted in a rapid transient increase in [Ca2+]i that could be blocked by Ni2+, La3+, or elevated K+.	lanthanum(3+)	208-212	carbonic anhydrase 2	Homo sapiens	122-125
1689544-7	1990	After depletion of the intracellular pool by stimulation in Ca2(+)-free medium, removal of the agonist and readmission of Ca2+ resulted in a rapid transient increase in [Ca2+]i that could be blocked by Ni2+, La3+, or elevated K+.	lanthanum(3+)	208-212	carbonic anhydrase 2	Homo sapiens	122-125
1689544-9	1990	These results suggest that two separate Ca2(+)-entry mechanisms, one sensitive to Ni2+, La3+, and elevated K+ and responsible for the agonist-induced increase in [Ca2+]i and one insensitive to the blockers and involved in refilling of the intracellular pool, may exist in salt gland cells.	lanthanum(3+)	88-92	carbonic anhydrase 2	Homo sapiens	40-43
2341023-5	1990	Cd2+ (2 x 10(-6) M) which had no effect on the tissue ATP concentration, inhibited La3+ resistant residual Ca2+ binding at the high and low affinity site.	lanthanum(3+)	83-87	T-cell surface antigen CD2	Cavia porcellus	0-3
2167905-5	1990	INa was not blockable by amiloride (0.1 mmol.l-1), a specific Na-channel blocker in epithelia, but a fully and reversible inhibition was achieved by mucosal application of 1 mmol.l-1 lanthanum (La3+).	lanthanum(3+)	194-198	internexin neuronal intermediate filament protein alpha S homeolog	Xenopus laevis	0-3
2402188-3	1990	Lanthanum chloride (La3+) effectively blocked NaF-stimulated increase in [Ca2+]i, but it blocked only CCK-stimulated late sustained phase of [Ca2+]i increase.	lanthanum(3+)	20-24	C-X-C motif chemokine ligand 8	Homo sapiens	46-49
33591184-3	2021	The promotion and suppression effects of La3+ ions on the crystallization of PbF2 were observed in this selective crystallization.	lanthanum(3+)	41-45	complement factor B	Homo sapiens	77-81
34783530-4	2021	Fe3+ reduced the critical concentration of tau required for the liquid-liquid phase separation (LLPS); however, Cr3+, La3+, and V3+ did not affect tau droplet formation.	lanthanum(3+)	118-122	microtubule associated protein tau	Homo sapiens	43-46
34516081-4	2021	Increasing the La3+ concentration (x > 1) leads to a reduction of some of the Ru2+ centers to Ru1+ centers and a suppression of the ferromagnetic state (lower Tc, reduced saturated ferromagnet moment).	lanthanum(3+)	15-19	doublecortin domain containing 2	Homo sapiens	78-81
34516081-4	2021	Increasing the La3+ concentration (x > 1) leads to a reduction of some of the Ru2+ centers to Ru1+ centers and a suppression of the ferromagnetic state (lower Tc, reduced saturated ferromagnet moment).	lanthanum(3+)	15-19	Scm like with four mbt domains 1	Homo sapiens	94-97
34777762-4	2021	Electrochemical studies show that the sensitivity of the GDH-based glutamate biosensor is remarkably enhanced in the presence of REE cations (i.e., Yb3+, La3+ or Eu3+) in solution, of which Yb3+ yields the highest sensitivity increase (ca.	lanthanum(3+)	154-158	glutamate dehydrogenase 1	Homo sapiens	57-60
34313127-4	2021	In the presence of redox-inactive metal ions such as Zn2+, La3+, Lu3+, and Y3+, the reaction does not form the hydroximatocobalt(III) complex but instead gives peroxyimidatocobalt(III) complexes, (CoIII(TBDAP)(R-C( NH)O2))2+ (R = Me (2) and Ph (2Ph)).	lanthanum(3+)	59-63	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	197-202
34284577-3	2021	Here, by doping Gd3+ ions into the La3+ sites in the La3Ga5GeO14 matrix, a 7.9-fold increase in the photoluminescence (PL) intensity of the Cr3+ ions, as well as a remarkably broadened full width at half-maximum (FWHM) of the corresponding PL spectra, is achieved.	lanthanum(3+)	35-39	GRDX	Homo sapiens	16-19
34340691-14	2021	La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4.	lanthanum(3+)	0-4	MDM2 proto-oncogene	Homo sapiens	153-157
34340691-14	2021	La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4.	lanthanum(3+)	0-4	RB transcriptional corepressor 1	Homo sapiens	159-162
34340691-14	2021	La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4.	lanthanum(3+)	0-4	ATM serine/threonine kinase	Homo sapiens	164-167
34340691-14	2021	La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4.	lanthanum(3+)	0-4	tumor protein p53	Homo sapiens	169-173
34340691-14	2021	La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4.	lanthanum(3+)	0-4	E2F transcription factor 1	Homo sapiens	175-179
34340691-14	2021	La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4.	lanthanum(3+)	0-4	cyclin dependent kinase 2	Homo sapiens	181-185
34340691-14	2021	La3+, Ce3+, and F- are probably the main toxic substances in WSPM, and may be regulate the A549 cell cycle by affecting the expression of genes, such as MDM2, RB1, ATM, TP53, E2F1, CDK2 and CDK4.	lanthanum(3+)	0-4	cyclin dependent kinase 4	Homo sapiens	190-194
34093849-7	2021	The La3+ dopants in the scaffolds promote proliferation and osteogenic differentiation of rBMSCs-OVX by activating Wnt/beta-catenin pathway, leading to high expression of ALP, Runx-2, COL-1 and OCN genes.	lanthanum(3+)	4-8	catenin beta 1	Rattus norvegicus	119-131
34093849-7	2021	The La3+ dopants in the scaffolds promote proliferation and osteogenic differentiation of rBMSCs-OVX by activating Wnt/beta-catenin pathway, leading to high expression of ALP, Runx-2, COL-1 and OCN genes.	lanthanum(3+)	4-8	RUNX family transcription factor 2	Rattus norvegicus	176-182
35148105-2	2022	In the present experiment, electron doping in Bi1/2K1/2VO3 was conducted through substituting K+ with La3+ to suppress the tetragonality and achieve NTE.	lanthanum(3+)	102-106	transmembrane BAX inhibitor motif containing 6	Homo sapiens	46-58
2531141-4	1989	Transient oscillations in [Ca2+]i were also observed when calcium influx was blocked with La3+.	lanthanum(3+)	90-94	carbonic anhydrase 2	Rattus norvegicus	27-30
2723639-5	1989	At the first phase, the elevation of cytosolic free Ca2+ concentration with high K+ stimuli was significantly inhibited by La3+ (20 microM) or by acidosis (pH 6.7).	lanthanum(3+)	123-127	carbonic anhydrase 2	Rattus norvegicus	52-55
2854113-2	1988	Anti-FT-1 induced a rapid and sustained increase in cytosolic free [Ca2+]i and this effect was completely blocked by EGTA and La3+.	lanthanum(3+)	126-130	AKT interacting protein	Mus musculus	5-9
3141421-10	1988	5) Exposure of cells to Mn2+ and La3+, which stimulate calmodulin-dependent activities, potently increased the S6 kinase activity of the cell extracts.	lanthanum(3+)	33-37	calmodulin 1	Homo sapiens	55-65
2853232-3	1988	Maximal activation of m-calpain by Ca2+, La3+, Ba2+, and Mn2+ occurs at 2 to 3 mM concentrations of each of these divalent cations, but La3+ activation is only 20 to 25% and Ba2+ and Mn2+ activation only 6 to 10% as great as Ca2+ activation.	lanthanum(3+)	41-45	calpain 2	Bos taurus	22-31
2853232-3	1988	Maximal activation of m-calpain by Ca2+, La3+, Ba2+, and Mn2+ occurs at 2 to 3 mM concentrations of each of these divalent cations, but La3+ activation is only 20 to 25% and Ba2+ and Mn2+ activation only 6 to 10% as great as Ca2+ activation.	lanthanum(3+)	136-140	calpain 2	Bos taurus	22-31
2851595-2	1988	Fura-2-loaded T51B cells responded with an increase in [Ca2+]i to EGF (5-50 ng/ml) that was blocked by low (25 microM) extracellular Ca2+ or by pretreatment with 50 microM La3+ to inhibit plasma membrane Ca2+ flux.	lanthanum(3+)	172-176	epidermal growth factor	Homo sapiens	66-69
2851595-4	1988	Low extracellular Ca2+ or addition of La3+ prevented the EGF-stimulated rise in labeled nuclei, indicating that a movement of Ca2+ into the cell was required for DNA synthesis.	lanthanum(3+)	38-42	epidermal growth factor	Homo sapiens	57-60
2847870-8	1988	Addition of La3+, verapamil or EGTA, but not of trifluoperazine, significantly inhibited the forskolin-stimulated (10 microM) ODC activity.	lanthanum(3+)	12-16	ornithine decarboxylase 1	Rattus norvegicus	126-129
3147336-8	1988	Neurite elongation rates and branching were increased by exposure to La3+ in neurons on either a CM or fibronectin substrate.	lanthanum(3+)	69-73	fibronectin 1	Homo sapiens	103-114
3675575-2	1987	Sufficient extracellular 45Ca could be removed by a 90 second cold La3+ was to reveal stimulation of 45Ca-uptake by high K+-depolarization and the vasopressor peptides angiotensin II and vasopressin.	lanthanum(3+)	67-71	arginine vasopressin	Rattus norvegicus	187-198
2887481-5	1987	Neurotensin-stimulated contraction was inhibited by "Ca2+-free" (pCa = 5.1) or La3+ buffer.	lanthanum(3+)	79-83	neurotensin/neuromedin N	Oryctolagus cuniculus	0-11
2446254-7	1987	In experiments with Ca2+, Ba2+ or Mg2+ as principal mucosal cation, the La3+-sensitive Isc component was negligible under control conditions and during oxytocin treatment.	lanthanum(3+)	72-76	mucin 7, secreted	Homo sapiens	34-37
3597392-7	1987	La3+, an ion that dissociates CaM from tightly bound CaM-enzyme systems, inhibited equine sperm adenylate cyclase (IC50 = 1 mM).	lanthanum(3+)	0-4	calmodulin-2	Equus caballus	30-33
3597392-7	1987	La3+, an ion that dissociates CaM from tightly bound CaM-enzyme systems, inhibited equine sperm adenylate cyclase (IC50 = 1 mM).	lanthanum(3+)	0-4	calmodulin-2	Equus caballus	53-56
3597392-8	1987	Incubation of equine sperm adenylate cyclase with La3+ dissociated endogenous CaM from the enzyme so that most of the enzyme bound to a CaM-Sepharose column equilibrated with Ca2+.	lanthanum(3+)	50-54	calmodulin-2	Equus caballus	78-81
3597392-8	1987	Incubation of equine sperm adenylate cyclase with La3+ dissociated endogenous CaM from the enzyme so that most of the enzyme bound to a CaM-Sepharose column equilibrated with Ca2+.	lanthanum(3+)	50-54	calmodulin-2	Equus caballus	136-139
3828382-4	1987	The organic calcium antagonist, nitrendipine, and the inorganic calcium channel blockers (Co2+, Mn2+, Cd2+, La3+) drastically inhibited rat and human platelet aggregation induced by thrombin, ADP or adrenaline in the presence of 0.32 mM Ca2+.	lanthanum(3+)	108-112	coagulation factor II, thrombin	Homo sapiens	182-190
2443646-20	1987	The relative potency for block by polyvalent cations was as follows (apparent dissociation constant in microM): La3+, 1.5 much greater than Ni2+, 47 greater than Cd2+, 160 = Co2+, 160 for type I channels, and La3+, 0.9 greater than Cd2+, 7.0 much greater than Ni2+, 280 greater than Co2+, 560 for type II channels.	lanthanum(3+)	112-116	CD2 antigen	Mus musculus	232-235
3025004-2	1986	Listed in the order of potency, the divalent cations Cd2+, Ni2+, Mn2+, Co2+, La3+ and Mg2+ depressed synaptic transmission.	lanthanum(3+)	77-81	T-cell surface antigen CD2	Cavia porcellus	53-56
3019337-1	1986	Calmodulin, spin labeled at Tyr-99, has been titrated with the lanthanides La3+, Nd3+, Eu3+, Tb3+, Er3+ and Lu3+ as well as Ca2+ and Cd2+.	lanthanum(3+)	75-79	calmodulin 1	Homo sapiens	0-10
3087803-7	1986	The stimulatory effect of lyso-PAF is largely independent of any toxic or lytic effect, being biphasic, reversible, unassociated with impairment of the subsequent physiologic functioning of treated islets, and inhibitable (by Ni2+, La3+, or nordihydroguaiaretic acid but not by other lipoxygenase inhibitors).	lanthanum(3+)	232-236	PCNA clamp associated factor	Rattus norvegicus	31-34
3511975-7	1986	The stimulatory effect of insulin was depressed in medium lacking external Ca2+, or containing the Ca2+-antagonistic ion, La3+, or the Ca2+ channel blocker, methoxyverapamil (D-600).	lanthanum(3+)	122-126	insulin	Bos taurus	26-33
3943538-6	1986	The activation phase could be restored to La3+-washed membranes by addition of calmodulin (Ka = 3.0 nM).	lanthanum(3+)	42-46	calmodulin 1	Homo sapiens	79-89
3943538-10	1986	The calmodulin antagonist trifluoperazine potently inhibited adenylate cyclase in native membranes (80%) and to a much lesser extent in La3+-washed membranes (15%).	lanthanum(3+)	136-140	calmodulin 1	Homo sapiens	4-14
3943538-11	1986	This inhibition was due to interaction of trifluoperazine with endogenous calmodulin since trifluoperazine competitively antagonized the stimulatory effect of calmodulin on adenylate cyclase in La3+-washed membranes.	lanthanum(3+)	194-198	calmodulin 1	Homo sapiens	74-84
3943538-11	1986	This inhibition was due to interaction of trifluoperazine with endogenous calmodulin since trifluoperazine competitively antagonized the stimulatory effect of calmodulin on adenylate cyclase in La3+-washed membranes.	lanthanum(3+)	194-198	calmodulin 1	Homo sapiens	159-169
3484478-3	1986	The EGF-induced [Ca2+]i rise is completely dependent on extracellular Ca2+, is abolished by La3+ and Mn2+, and is not accompanied by changes in membrane potential (mean values of -64 mV).	lanthanum(3+)	92-96	epidermal growth factor	Homo sapiens	4-7
4066663-3	1985	In the present study, we find that the metal cations La3+, Tb3+, Pb2+, and Cd2+ are all capable of abolishing the cooperativity (Hill coefficient = 2.0) among the two felodipine-binding sites on calmodulin and can increase the apparent affinity of calmodulin for felodipine by approximately 20-fold.	lanthanum(3+)	53-57	calmodulin 1	Homo sapiens	195-205
4066663-3	1985	In the present study, we find that the metal cations La3+, Tb3+, Pb2+, and Cd2+ are all capable of abolishing the cooperativity (Hill coefficient = 2.0) among the two felodipine-binding sites on calmodulin and can increase the apparent affinity of calmodulin for felodipine by approximately 20-fold.	lanthanum(3+)	53-57	calmodulin 1	Homo sapiens	248-258
4066663-6	1985	In each case, the calcium-binding sites of calmodulin must be occupied (by calcium, La3+, Tb3+, Pb2+, or by Cd2+) before these metals can bind to sites which are distinct from the calcium-binding sites to produce the active conformer of calmodulin which exhibits enhanced affinity for felodipine.	lanthanum(3+)	84-88	calmodulin 1	Homo sapiens	43-53
4066663-8	1985	These studies suggest that some metals including La3+, Tb3+, Pb2+, Cd2+, Zn2+ and protons are capable of binding to a calcium-calmodulin complex and forming an allosterically active species of calmodulin which cannot be maintained by physiological concentrations of calcium ions alone.	lanthanum(3+)	49-53	calmodulin 1	Homo sapiens	126-136
4066663-8	1985	These studies suggest that some metals including La3+, Tb3+, Pb2+, Cd2+, Zn2+ and protons are capable of binding to a calcium-calmodulin complex and forming an allosterically active species of calmodulin which cannot be maintained by physiological concentrations of calcium ions alone.	lanthanum(3+)	49-53	calmodulin 1	Homo sapiens	193-203
3977849-6	1985	EGTA was ineffective in removing calmodulin from particulate preparations, but treatment with the tervalent metal ion La3+ resulted in a loss of up to 98% of calmodulin activity from these preparations.	lanthanum(3+)	118-122	calmodulin 1	Homo sapiens	158-168
3977849-7	1985	Addition of La3+ directly to the adenylate cyclase assay resulted in a partial inhibition of TSH- and NaF-stimulated activity, with 50% inhibition produced by 5.1 microM and 4.0 microM-La3+ respectively.	lanthanum(3+)	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
3977849-7	1985	Addition of La3+ directly to the adenylate cyclase assay resulted in a partial inhibition of TSH- and NaF-stimulated activity, with 50% inhibition produced by 5.1 microM and 4.0 microM-La3+ respectively.	lanthanum(3+)	185-189	C-X-C motif chemokine ligand 8	Homo sapiens	102-105
3977849-8	1985	Particulate preparations with La3+ showed a decrease of TSH- and NaF-stimulated adenylate cyclase activity (approx.	lanthanum(3+)	30-34	C-X-C motif chemokine ligand 8	Homo sapiens	65-68
3977849-11	1985	In particulate preparations from which endogenous calmodulin had been removed by La3+ treatment, the addition of pure calmodulin caused an increase (73 +/- 22%; mean +/- S.E.M., n = 8) in TSH-stimulated thyroid adenylate cyclase activity.	lanthanum(3+)	81-85	calmodulin 1	Homo sapiens	118-128
2423167-8	1985	Serosal La3+ apparently inactivates the hormone-receptor interaction and/or the link between the ADH-receptor complex and the activation of adenylate cyclase, but does not interfere with the operation of the Na+ "pump", the basal activity of adenylate cyclase or any of the intracellular events that mediate the effect of ADH on Na+ transport.	lanthanum(3+)	8-12	nuclear receptor subfamily 4 group A member 1	Homo sapiens	40-56
2987504-5	1985	The cytochrome c mediated absorbance and fluorescence losses of diS-C3-(5) in liposomal or proteoliposomal systems are prevented by Ca2+ and La3+ ions, by ascorbate, by high ionic strength and by the antioxidant BHT.	lanthanum(3+)	141-145	cytochrome c, somatic	Homo sapiens	4-16
6097217-4	1984	However, the rare-earth-metal ion La3+, which can mimic or replace Ca2+ in many systems, produced an immediate inhibition of agonist-stimulated adenylate cyclase activity and preincubation of particulate preparations was La3+ followed by washing with La3+-free buffer dissociated calmodulin (96% loss) from particulate preparations.	lanthanum(3+)	34-38	calmodulin 2	Mus musculus	280-290
6096858-4	1984	AII-stimulated 45Ca2+ release was blocked by the angiotensin antagonist [1-sarcosine, 8-leucine]AII and by La3+.	lanthanum(3+)	107-111	angiotensinogen	Rattus norvegicus	0-3
6093821-1	1984	The influence of Ca2+, Mg2+, Mn2+, Sr2+, La3+, Nd3+, Sm3+, Eu3+, and Gd3+ ions on the binding of labeled, stable enkephalin analogue, [3H-Tyr1, D-Ala2, D-Leu5]enkephalin, to opiate receptors of the rat brain membrane preparations has been investigated.	lanthanum(3+)	41-45	proenkephalin	Rattus norvegicus	113-123
6145600-6	1984	At higher concentrations, Cd2+ is either relatively impermeable to the presynaptic nerve membrane or, if it does enter the nerve terminal, it is less effective than such metals as Pb2+, La3+ or Hg2+ in increasing the rate of spontaneous transmitter release.	lanthanum(3+)	186-190	CD2 molecule	Homo sapiens	26-29
6698809-13	1984	Exposure of the tissue to La3+ resulted in the complete absence of sarcolemma-bound precipitate suggesting that the Ca2+ is exchangeable.	lanthanum(3+)	26-30	carbonic anhydrase 2	Rattus norvegicus	116-119
6140165-4	1983	Removal of endogenous calmodulin by La3+-treatment of ciliary membranes resulted in loss of guanylate cyclase activity.	lanthanum(3+)	36-40	calmodulin-3	Sus scrofa	22-32
6138352-1	1983	Dissociation of calmodulin by La3+: calmodulin specificity and properties of the reconstituted guanylate cyclase.	lanthanum(3+)	30-34	calmodulin-3	Sus scrofa	16-26
6138352-1	1983	Dissociation of calmodulin by La3+: calmodulin specificity and properties of the reconstituted guanylate cyclase.	lanthanum(3+)	30-34	calmodulin-3	Sus scrofa	36-46
6138352-4	1983	EGTA did not easily release calmodulin; however, La3+ inhibited guanylate cyclase by dissociation of calmodulin.	lanthanum(3+)	49-53	calmodulin-3	Sus scrofa	101-111
6416677-5	1983	The reduction of environmental and plasma membrane associated Ca2+ with the chelators and La3+ promoted the metaphase to telophase progression as well as nuclear envelope and micronuclei formation.	lanthanum(3+)	90-94	carbonic anhydrase 2	Cricetulus griseus	62-65
6688112-0	1983	Comparative abilities of lanthanide ions La3+ and Tb3+ to substitute for Ca2+ in regulating phospholipid-sensitive Ca2+-dependent protein kinase and myosin light chain kinase.	lanthanum(3+)	41-45	myosin light chain kinase	Rattus norvegicus	149-174
6305741-8	1983	The enzyme had a pH optimal value of about 7.0 and an apparent Km for cCMP about 2.8 mM; its activity was slightly affected by the presence of calmodulin (100 micrograms/ml) and/or CaCl2 (100 microM), but showed variable responses to other cations (La3+, Mg2+, Mn2+, Zn2+, Fe2+, Na+ and K+).	lanthanum(3+)	249-253	calmodulin 1	Rattus norvegicus	143-153
6216324-6	1982	La3+ produced uncompetitive inhibition of Ca2+-ATPase in intact synaptosomes.	lanthanum(3+)	0-4	dynein, axonemal, heavy chain 8	Mus musculus	47-53
6292689-3	1982	Sc3+ bears the same relationship to Mg2+ as La3+ to Ca2+, a similar ionic radius but increased charge.	lanthanum(3+)	44-48	secretory carrier membrane protein 3	Mus musculus	0-3
6281099-5	1982	The Ca2+ antagonists verapamil (10-4 M), methoxy-verapamil (10-4 M) and La3+ (10-3 M) inhibited the dispersion induced by 3 X 10-9 M alpha-MSH, whereas ruthenium red (10-3 M) was without effect.	lanthanum(3+)	72-76	proopiomelanocortin S homeolog	Xenopus laevis	133-142
6266953-9	1981	A Ca2+-free medium, La3+, and verapamil produced a 75% inhibition of the direct tonin-induced contraction.	lanthanum(3+)	20-24	kallikrein 1-related peptidase C2	Rattus norvegicus	80-85
6787406-5	1981	La3+ inhibits ATC Ca2+ extrusion whereas Ruthenium Red slightly decreases cell calcium content.	lanthanum(3+)	0-4	carbonic anhydrase 2	Mus musculus	18-21
7223893-0	1981	Effect of La3+ on secretagogue-induced Ca2+ fluxes in rat isolated pancreatic acinar cells.	lanthanum(3+)	10-14	carbonic anhydrase 2	Rattus norvegicus	39-42
7223893-6	1981	In the presence of 2 mmol/l La3+, the atropine-induced 45Ca2+ uptake in CCh-pretreated cells and the dibutyryl guanosine 3",5"-cyclic monophosphate-induced 45Ca2+ uptake in CCK-OP-pretreated cells were highly reduced.	lanthanum(3+)	28-32	cholecystokinin	Rattus norvegicus	173-176
7338276-6	1981	Neuraminidase treatment promoted the described La3+ effects.	lanthanum(3+)	47-51	neuraminidase 1	Homo sapiens	0-13
6251913-1	1980	La3+ was found to inhibit the secretion of 5-hydroxytryptamine and the production of thromboxane B2 by washed platelets exposed to collagen or thrombin.	lanthanum(3+)	0-4	coagulation factor II, thrombin	Homo sapiens	143-151
7470991-3	1980	The stimulation of sugar transport by insulin, hyperosmolarity, K+-free medium, or 10(-5) M ouabain was strongly antagonized by Ni2+, Zn2+, and La3+ but was unaffected by Co2+ and Mn2+.	lanthanum(3+)	144-148	insulin	Cavia porcellus	38-45
508856-0	1979	[Reversible precipitation of the glucocorticoid receptor from rat liver by La3+ ions].	lanthanum(3+)	75-79	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	33-56
508856-1	1979	It was shown that La3+ ions are capable of precipitating the glucocorticoid receptor from rat liver.	lanthanum(3+)	18-22	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	61-84
508856-6	1979	It is suggested that precipitation by La3+ ions can be used for separation of the receptor from transcortin and transcortin-like proteins as well as for evaluation of binding parameters for steroid-receptor complexes in rat liver cytosol.	lanthanum(3+)	38-42	serpin family A member 6	Rattus norvegicus	96-107
508856-6	1979	It is suggested that precipitation by La3+ ions can be used for separation of the receptor from transcortin and transcortin-like proteins as well as for evaluation of binding parameters for steroid-receptor complexes in rat liver cytosol.	lanthanum(3+)	38-42	serpin family A member 6	Rattus norvegicus	112-123
464093-6	1979	La3+ at 1 X 10(-3) M behaved like Ca2+-free incubation but produced sustained contractions with muscle stimulation.	lanthanum(3+)	0-4	carbonic anhydrase 2	Homo sapiens	34-37
691040-6	1978	In other experiments, the use of La3+ to inhibit the Ca2+-pump allowed an estimate of the ATPase activity associated with Ca2+ extrusion.	lanthanum(3+)	33-37	dynein axonemal heavy chain 8	Homo sapiens	90-96
204905-4	1978	Interestingly, La3+ is also able to inhibit NAT after DBcAMP, indicating that Ca2+ can also control enzyme induction at an intracellular site beyond the beta-receptor.	lanthanum(3+)	15-19	N-acetyltransferase 1	Rattus norvegicus	44-47
14139-10	1977	Calcium binding at 1 muM calcium was 50% inhibited by 18 muM La3+, 600 muM Sr2+, or 2.7 mM Ba2+.	lanthanum(3+)	61-65	latexin	Homo sapiens	21-24
14139-10	1977	Calcium binding at 1 muM calcium was 50% inhibited by 18 muM La3+, 600 muM Sr2+, or 2.7 mM Ba2+.	lanthanum(3+)	61-65	latexin	Homo sapiens	57-60
14139-10	1977	Calcium binding at 1 muM calcium was 50% inhibited by 18 muM La3+, 600 muM Sr2+, or 2.7 mM Ba2+.	lanthanum(3+)	61-65	latexin	Homo sapiens	57-60
12752-8	1976	La3+ ions lower the mobilities and zeta potentials in the range 10 muM-1 mM, and the cells become positively charged above 1 mM.	lanthanum(3+)	0-4	PWWP domain containing 3A, DNA repair factor	Mus musculus	67-72
12752-16	1976	Ca2+ ions do not markedly increase aggregation, whereas La3+ ions gave rise to extensive aggregation in the range 10 muM-1 mM, corresponding to the region of La3+ adsorption.	lanthanum(3+)	56-60	PWWP domain containing 3A, DNA repair factor	Homo sapiens	117-122
1161044-6	1975	These late changes in force of contraction also occurred after short exposure to 500 muM La3+ (2 min) when La3+ had been removed from the medium.	lanthanum(3+)	89-93	latexin	Homo sapiens	85-88
1161044-6	1975	These late changes in force of contraction also occurred after short exposure to 500 muM La3+ (2 min) when La3+ had been removed from the medium.	lanthanum(3+)	107-111	latexin	Homo sapiens	85-88
1161044-11	1975	500 muM La3+ reduced the force of contraction to the control value obtained before addition of ouabain (5x10(-7)M).	lanthanum(3+)	8-12	latexin	Homo sapiens	4-7
33713955-7	2021	Meanwhile, similar to the blocking effect of the specific SOC inhibitors Gd3+ and La3+ on LPS-induced calcium influx, RNAi-mediated depletion of STIM1 or the SOC proteins TRPC1 and ORAI1 could significantly inhibit serum or LPS-induced extracellular calcium influx, as well as the expression of the inflammatory cytokines tumor necrosis factor, intercellular cell adhesion molecule-1, and endothelin-1.	lanthanum(3+)	82-86	transient receptor potential cation channel subfamily C member 1	Homo sapiens	171-176
33713955-7	2021	Meanwhile, similar to the blocking effect of the specific SOC inhibitors Gd3+ and La3+ on LPS-induced calcium influx, RNAi-mediated depletion of STIM1 or the SOC proteins TRPC1 and ORAI1 could significantly inhibit serum or LPS-induced extracellular calcium influx, as well as the expression of the inflammatory cytokines tumor necrosis factor, intercellular cell adhesion molecule-1, and endothelin-1.	lanthanum(3+)	82-86	ORAI calcium release-activated calcium modulator 1	Homo sapiens	181-186
34042270-4	2021	Anesthetized male Sprague-Dawley rats were infused with Ang II (80 ng kg-1  min-1 ) alone, or together with clemizole or low-dose La3+ (activates TRPC5, blocks TRPC6) or high-dose La3+ (blocks both TRPC5 and TRPC6).	lanthanum(3+)	130-134	transient receptor potential cation channel, subfamily C, member 5	Rattus norvegicus	146-151
34042270-4	2021	Anesthetized male Sprague-Dawley rats were infused with Ang II (80 ng kg-1  min-1 ) alone, or together with clemizole or low-dose La3+ (activates TRPC5, blocks TRPC6) or high-dose La3+ (blocks both TRPC5 and TRPC6).	lanthanum(3+)	130-134	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	160-165
34042270-7	2021	In contrast, high- and low-dose La3+ significantly lowered DeltaMAP and reduced Ang II-induced hyperpermeability.	lanthanum(3+)	32-36	angiotensinogen	Rattus norvegicus	80-86
34042270-8	2021	Combined, clemizole and low-dose La3+ were less effective at ameliorating Ang II-induced glomerular hyperpermeability than low-dose La3+ alone.	lanthanum(3+)	33-37	angiotensinogen	Rattus norvegicus	74-80
34042270-9	2021	In conclusion, our data show that both clemizole and La3+ are effective against Ang II-induced glomerular hyperpermeability, with differential effects on blood pressure.	lanthanum(3+)	53-57	angiotensinogen	Rattus norvegicus	80-86
33103417-4	2020	Our studies reveal that substitution of the pyridyl-2-carboxylic acid pendent arms of macropa with pyridyl-2-phosphinic acid arms of macrophosphi gives rise to a dramatic enhancement in the ability to discriminate between light lanthanides, reflected by a binding affinity of macrophosphi for La3+ that is over 5 orders of magnitude higher than that for Gd3+.	lanthanum(3+)	293-297	GRDX	Homo sapiens	354-357
32915187-2	2020	The XAS and MD results show that major changes take place in the La3+ first solvation shell when moving from pure acetonitrile to pure C8(mim)2(Tf2N)2.	lanthanum(3+)	65-69	homeobox C8	Homo sapiens	135-143
32915187-4	2020	Except in pure C8(mim)2(Tf2N)2, La3+ is always able to coordinate both acetonitrile and Tf2N- anions, with a ratio between the two different ligands strongly dependent on the IL content.	lanthanum(3+)	32-36	homeobox C8	Homo sapiens	15-23
32915187-6	2020	In particular, when moving from pure acetonitrile to pure C8(mim)2(Tf2N)2, the La3+ first solvation shell passes from a bicapped square antiprism geometry where all the Tf2N- anions act only as monodentate ligands, to a "1 + 5 + 4" structure in which the Tf2N- anion binds La3+ both in a monodentate and bidentate fashion.	lanthanum(3+)	79-83	homeobox C8	Homo sapiens	58-66
32915187-6	2020	In particular, when moving from pure acetonitrile to pure C8(mim)2(Tf2N)2, the La3+ first solvation shell passes from a bicapped square antiprism geometry where all the Tf2N- anions act only as monodentate ligands, to a "1 + 5 + 4" structure in which the Tf2N- anion binds La3+ both in a monodentate and bidentate fashion.	lanthanum(3+)	273-277	homeobox C8	Homo sapiens	58-66
32816482-2	2020	Here we introduce Raman difference with simultaneous curve fitting (RD-SCF) analysis to extract the OH-stretch spectrum of hydration shell water, not only for the fully hydrated ions (Mg2+, La3+ and Cl-) but also for the ion pairs.	lanthanum(3+)	190-194	KIT ligand	Homo sapiens	71-74
32816482-3	2020	RD-SCF analyses of diluted MgCl2 (0.18 M) and LaCl3 (0.12 M) solutions relative to aqueous NaCl of equivalent Cl- concentrations provide the OH-stretch spectra of water in the hydration shells of fully hydrated Mg2+ and La3+ cations relative to that of Na+.	lanthanum(3+)	220-224	KIT ligand	Homo sapiens	3-6
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	lanthanum(3+)	248-252	KIT ligand	Homo sapiens	98-101
32816482-6	2020	The OH-stretch spectrum of the shared/intervening water in the SSIP, retrieved by second-round RD-SCF analysis (2RD-SCF), shows that the average H-bonding of the shared water is weaker than the hydration water of the fully hydrated cation (Mg2+ or La3+) but stronger than that of the anion (Cl-).	lanthanum(3+)	248-252	KIT ligand	Homo sapiens	116-119
32305361-8	2020	Shear-stress-induced ATP release was eliminated by connexin (Cx) 43 hemichannel inhibition using La3+, Gap19, or knock-down of Cx43 expression.	lanthanum(3+)	97-101	gap junction protein alpha 1	Homo sapiens	51-67
31733625-4	2019	Here we show that ET coupling in HEK293 cells transfected with wt Cav1.2 or the Timothy mutant Cav1.2G406R is mediated by substituting Ca2+ with the impermeable lanthanum (La3+).	lanthanum(3+)	172-176	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	66-72
30826858-8	2019	Similar results were obtained when La3+ and Sr2+ were used as CaSR agonists.	lanthanum(3+)	35-39	calcium-sensing receptor	Mus musculus	62-66
30167872-5	2019	We confirmed that La3+ increased the level of antioxidant protective enzymes, including superoxide dismutase (SOD) and peroxidase (POD), while it significantly decreased malondialdehyde (MDA) content.	lanthanum(3+)	18-22	peroxidase 12-like	Vigna angularis	119-129
30167872-5	2019	We confirmed that La3+ increased the level of antioxidant protective enzymes, including superoxide dismutase (SOD) and peroxidase (POD), while it significantly decreased malondialdehyde (MDA) content.	lanthanum(3+)	18-22	peroxidase 12-like	Vigna angularis	131-134
31550088-8	2019	High CBX concentrations or the inhibitor La3+, both effective on Cx hemichannels, were needed to inhibit the dye uptake.	lanthanum(3+)	41-45	LOC100128922	Homo sapiens	65-67
30160712-0	2018	High-efficiency 2  mum continuous-wave laser in laser diode-pumped Tm3+, La3+: CaF2 single crystal.	lanthanum(3+)	73-77	CCR4-NOT transcription complex subunit 8	Homo sapiens	79-83
28916337-7	2017	Moreover, measurement of Fluo-3 image showed that Ang II increased intracellular Ca2+ level, as N-MPG and La3+ impeded Ang II induced Ca2+ influx.	lanthanum(3+)	106-110	angiotensinogen	Homo sapiens	50-56
28916337-7	2017	Moreover, measurement of Fluo-3 image showed that Ang II increased intracellular Ca2+ level, as N-MPG and La3+ impeded Ang II induced Ca2+ influx.	lanthanum(3+)	106-110	angiotensinogen	Homo sapiens	119-125
28331185-5	2017	Ang II-induced calcium flux was decreased upon inhibition of TRPC channels with SAR7334, SKF 96365, clemizole hydrochloride and La3+, but not ML204.	lanthanum(3+)	128-132	angiotensinogen	Homo sapiens	0-6
27806271-8	2016	These hexameric Orai1 channels displayed the biophysical fingerprint of native CRAC channels, including the distinguishing characteristics of gating (store-dependent activation, Ca2+-dependent inactivation, open probability), permeation (ion selectivity, affinity for Ca2+ block, La3+ sensitivity, unitary current magnitude), and pharmacology (enhancement and inhibition by 2-aminoethoxydiphenyl borate).	lanthanum(3+)	280-284	ORAI calcium release-activated calcium modulator 1	Homo sapiens	16-21
27367668-7	2016	Under non-stimulated conditions, hypotonicity-induced trafficking of AQP5 to the APM was inhibited by ruthenium red and La(3+), suggesting the involvement of extracellular Ca(2+) entry.	lanthanum(3+)	120-126	aquaporin 5	Rattus norvegicus	69-73
27163769-8	2016	Vascular endothelial growth factor (VEGF) also increased Ca2+-influx and induced corresponding inward currents more in hPtEC than in HCjEC, whereas CPZ (20 muM), BCTC (20 muM), or La3+ (500 muM) reduced these responses, respectively.	lanthanum(3+)	180-184	vascular endothelial growth factor A	Homo sapiens	36-40
26449341-5	2016	Additionally, a Ca(2+) and La(3+) sensitive current was observed in HeLa cells expressing eGFP-labeled hCx46wt or eGFP-labeled hCx46N188T.	lanthanum(3+)	27-33	gap junction protein alpha 3	Homo sapiens	103-108
26320834-6	2015	The increase in [Ca(2+)]i by OlyA/PlyB was partially prevented by: i) the calcium channel blockers verapamil and La(3+), ii) the inhibitor of the sodium-calcium exchanger (NCX) benzamil, and iii) the iso-osmotic replacement of NaCl by sucrose.	lanthanum(3+)	113-119	T cell leukemia homeobox 2	Homo sapiens	172-175
26446257-6	2015	These Ca(2+) hotspots were only marginally reduced by the SOCE channel blocker lanthanum chloride (La(3+)) but were abrogated by inositol trisphosphate receptor inhibitors 2-APB and xestospongin-C, revealing that unlike STIM1-mediated hotspots, junctate-mediated Ca(2+) originates predominantly from periphagosomal Ca(2+) stores.	lanthanum(3+)	99-105	stromal interaction molecule 1	Homo sapiens	220-225
26446257-6	2015	These Ca(2+) hotspots were only marginally reduced by the SOCE channel blocker lanthanum chloride (La(3+)) but were abrogated by inositol trisphosphate receptor inhibitors 2-APB and xestospongin-C, revealing that unlike STIM1-mediated hotspots, junctate-mediated Ca(2+) originates predominantly from periphagosomal Ca(2+) stores.	lanthanum(3+)	99-105	aspartate beta-hydroxylase	Homo sapiens	245-253
30090262-7	2015	We demonstrate that La3+ accumulates in the bone following IV dose of either La(dpp)3 or La(XT) and we have investigated the influence of each chelating ligand on the incorporation of La3+ into HAP using ITC and HAP-binding studies.	lanthanum(3+)	20-24	dipeptidyl peptidase 3	Homo sapiens	77-85
26267167-7	2015	The plasma membrane Ca2+-channel Cch1/Mid1 contributed to La3+ and Gd3+ entry into the cells, with a significant preference for La3+.	lanthanum(3+)	58-62	midline 1	Homo sapiens	38-42
26230263-4	2015	In the combined treatment of La3+ (0.08 mM) and AR, the cell membrane permeability and the peroxidation of cell membrane lipid of soybean roots increased, and the superoxide dismutase, catalase, peroxidase and reduced ascorbic acid served as scavengers of reactive oxygen species.	lanthanum(3+)	29-33	catalase-3	Glycine max	185-193
26230263-4	2015	In the combined treatment of La3+ (0.08 mM) and AR, the cell membrane permeability and the peroxidation of cell membrane lipid of soybean roots increased, and the superoxide dismutase, catalase, peroxidase and reduced ascorbic acid served as scavengers of reactive oxygen species.	lanthanum(3+)	29-33	peroxidase	Glycine max	195-205
26017975-10	2015	Consistent with this, La(3+)-sensitive cationic currents activated by a diacylglycerol analog were increased in TNF-treated cells.	lanthanum(3+)	22-28	tumor necrosis factor	Homo sapiens	112-115
26063124-5	2015	With the increase of La(3+) ion contents, the decrease of Nd/La-O bond ionicity was observed, which could be attributed to the electric polarization.	lanthanum(3+)	21-27	interleukin 4 induced 1	Homo sapiens	61-65
25001925-6	2014	The solid state crystal structure of the La(3+) complex of Me2TPhen is determined using the single crystal X-ray diffraction (SCXRD) technique.	lanthanum(3+)	41-47	malic enzyme 2	Homo sapiens	59-62