PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15797961-4	2005	NPB evoked sizable cAMP and inositol triphosphate responses from ZF/R cells, which were abrogated by the adenylate cyclase inhibitor SQ-22536 and the phospholipase C inhibitor U-73122, respectively.	Inositol triphosphate	28-49	neuropeptide B	Homo sapiens	0-3
16129978-7	2005	The preconditioning period was associated with an increase in basal intracellular Ca2+ concentration of 7-15%, which involved Ca2+ release from inositol triphosphate-sensitive stores in the endoplasmic reticulum, and transient phosphorylation of mitogen-activated protein kinase p42/44 and the survival-associated proteins Akt and GSK-3beta.	Inositol triphosphate	144-165	carbonic anhydrase 2	Rattus norvegicus	82-85
16213217-8	2005	We show that Rho/Rac-family GTPases and the signaling molecule inositol triphosphate (IP(3)) act downstream of VAV-1 signaling and that the VAV-1 pathway modulates rhythmic behaviors by dynamically regulating the concentration of intracellular Ca(2+).	Inositol triphosphate	63-84	Protein vav-1	Caenorhabditis elegans	111-116
16213217-8	2005	We show that Rho/Rac-family GTPases and the signaling molecule inositol triphosphate (IP(3)) act downstream of VAV-1 signaling and that the VAV-1 pathway modulates rhythmic behaviors by dynamically regulating the concentration of intracellular Ca(2+).	Inositol triphosphate	63-84	Protein vav-1	Caenorhabditis elegans	140-145
15592583-7	2004	Vasoactive testicular paracrine hormones such as angiotensin II (AII) and vasopressin acting via inositol triphosphate generation induce cytosolic calcium rise predominantly derived from the thapsigargin-sensitive endoplasmic reticulum.	Inositol triphosphate	97-118	angiotensinogen	Homo sapiens	49-63
15522209-9	2004	These results therefore suggest that PLCgamma1 is involved in dynamic regulation of protein kinase C activity and inositol triphosphate levels in response to cellular needs.	Inositol triphosphate	114-135	phospholipase C, gamma 1	Rattus norvegicus	37-46
16025745-10	2005	In conclusion, Ang II shortened atrial APDs of SHRs via AT1a coupled with the Gq-mediated inositol triphosphate (IP3)-PKC pathway.	Inositol triphosphate	90-111	angiotensinogen	Rattus norvegicus	15-21
15592583-7	2004	Vasoactive testicular paracrine hormones such as angiotensin II (AII) and vasopressin acting via inositol triphosphate generation induce cytosolic calcium rise predominantly derived from the thapsigargin-sensitive endoplasmic reticulum.	Inositol triphosphate	97-118	angiotensinogen	Homo sapiens	65-68
15592583-7	2004	Vasoactive testicular paracrine hormones such as angiotensin II (AII) and vasopressin acting via inositol triphosphate generation induce cytosolic calcium rise predominantly derived from the thapsigargin-sensitive endoplasmic reticulum.	Inositol triphosphate	97-118	arginine vasopressin	Homo sapiens	74-85
12482596-1	2002	Increase in the intracellular inositol triphosphate (IP3) levels in Xenopus oocytes in response to expression and activation of rat angiotensin II (Ang II) receptor AT1 was inhibited by co-expression of rat AT2 receptor.	Inositol triphosphate	30-51	angiotensinogen	Rattus norvegicus	148-154
15356170-7	2004	In vitro C3aR is functional in terms of its capacity to bind 125I-labeled C3a and generate inositol triphosphate.	Inositol triphosphate	91-112	complement C3a receptor 1	Homo sapiens	9-13
15356170-7	2004	In vitro C3aR is functional in terms of its capacity to bind 125I-labeled C3a and generate inositol triphosphate.	Inositol triphosphate	91-112	complement C3	Homo sapiens	9-12
15128291-9	2004	On the endoplasmic reticulum, TRPV1 is present in two differentially regulated forms, one of which is inositol triphosphate-dependent whereas the other is not.	Inositol triphosphate	102-123	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-35
14724250-1	2004	Disruptions in intracellular Ca2+ signaling are proposed to underlie the pathophysiology of Alzheimer"s disease (AD), and it has recently been shown that AD-linked mutations in the presenilin 1 gene (PS1) enhance inositol triphosphate (IP3)-mediated Ca2+ liberation in nonexcitable cells.	Inositol triphosphate	213-234	presenilin 1	Mus musculus	181-193
14724250-1	2004	Disruptions in intracellular Ca2+ signaling are proposed to underlie the pathophysiology of Alzheimer"s disease (AD), and it has recently been shown that AD-linked mutations in the presenilin 1 gene (PS1) enhance inositol triphosphate (IP3)-mediated Ca2+ liberation in nonexcitable cells.	Inositol triphosphate	213-234	presenilin 1	Mus musculus	200-203
12499871-1	2002	Multiple calcium signaling pathways, including intracellular calcium release that is mediated by inositol triphosphate (IP3) or ryanodine calcium store receptors, seem to be involved in CA1 hippocampal synaptic plasticity.	Inositol triphosphate	97-118	carbonic anhydrase 1	Homo sapiens	186-189
14618376-4	2004	Inositol triphosphate (IP(3)) in yeast is rapidly transformed into IP(4) and IP(5) by a dual kinase, Arg82.	Inositol triphosphate	0-21	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	101-106
14505576-2	2003	For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an intracellular store calcium channel, the IP(3)R.	Inositol triphosphate	13-34	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-146
12641450-4	2003	SCP-2 bound to microsomes in vitro and overexpression of SCP-2 in transfected L-cells resulted in the following: (i) redistribution of phosphatidylinositols from intracellular membranes (mitochondria and microsomes) to the plasma membrane; (ii) enhancement of insulin-mediated inositol-triphosphate production; and (iii) 5.5-fold down regulation of PITP.	Inositol triphosphate	277-298	sterol carrier protein 2	Homo sapiens	0-5
12641450-4	2003	SCP-2 bound to microsomes in vitro and overexpression of SCP-2 in transfected L-cells resulted in the following: (i) redistribution of phosphatidylinositols from intracellular membranes (mitochondria and microsomes) to the plasma membrane; (ii) enhancement of insulin-mediated inositol-triphosphate production; and (iii) 5.5-fold down regulation of PITP.	Inositol triphosphate	277-298	sterol carrier protein 2	Homo sapiens	57-62
12482596-1	2002	Increase in the intracellular inositol triphosphate (IP3) levels in Xenopus oocytes in response to expression and activation of rat angiotensin II (Ang II) receptor AT1 was inhibited by co-expression of rat AT2 receptor.	Inositol triphosphate	30-51	angiotensin II receptor, type 1a	Rattus norvegicus	165-168
12482596-1	2002	Increase in the intracellular inositol triphosphate (IP3) levels in Xenopus oocytes in response to expression and activation of rat angiotensin II (Ang II) receptor AT1 was inhibited by co-expression of rat AT2 receptor.	Inositol triphosphate	30-51	angiotensin II receptor, type 2	Rattus norvegicus	207-210
11590206-2	2001	In this study, we demonstrate that ApoE initiates a signaling cascade in murine peritoneal macrophages that leads to increased production of inositol triphosphate with mobilization of intracellular Ca(2+) stores.	Inositol triphosphate	141-162	apolipoprotein E	Mus musculus	35-39
12376663-4	2002	This production was due to the simultaneous activation of phospholipase C (through diacylglycerol kinase activity) and phospholipase D, as monitored by the production of inositol triphosphate and of transphosphatidylation product, respectively.	Inositol triphosphate	170-191	phospholipase C1	Arabidopsis thaliana	58-73
12376663-4	2002	This production was due to the simultaneous activation of phospholipase C (through diacylglycerol kinase activity) and phospholipase D, as monitored by the production of inositol triphosphate and of transphosphatidylation product, respectively.	Inositol triphosphate	170-191	phospholipase D delta	Arabidopsis thaliana	119-134
11710940-8	2001	The increase in keratinocyte intracellular free calcium and inositol triphosphate levels following 1,25-dihydroxyvitamin D3 administration were markedly reduced by the transfection of the antisense phospholipase C-gamma1 construct.	Inositol triphosphate	60-81	phospholipase C gamma 1	Homo sapiens	198-220
11710940-9	2001	These studies indicate that phospholipase C-gamma1 plays a critical role in the signal transduction pathway mediating 1,25-dihydroxyvitamin-D3-induced keratinocyte differentiation at least in part by mediating the increase in inositol triphosphate production and intracellular calcium mobilization following 1,25-dihydroxyvitamin D3 administration.	Inositol triphosphate	226-247	phospholipase C gamma 1	Homo sapiens	28-50
12558193-6	2002	RESULTS: Although FMLP-activated generation of inositol triphosphate and mobilisation of Ca2+ from neutrophil internal stores, as well as the magnitude of the subsequent efflux and store-operated influx of the cation were unaffected by ADA, there was a prolonged elevation in cytosolic Ca2+ in the presence of the enzyme, which was associated with failure to activate adenylate cyclase and with increased production of superoxide and release of elastase.	Inositol triphosphate	47-68	formyl peptide receptor 1	Homo sapiens	18-22
12201805-10	2002	CRH/urocortin, via specific receptor isoforms, is now able to activate Gq and potentially enhance the oxytocin-driven generation of inositol triphosphate.	Inositol triphosphate	132-153	corticotropin releasing hormone	Homo sapiens	0-3
11179511-12	2001	ETA-receptor activation raised inositol triphosphate (IP3) production from dispersed ZF/R cells, while ETB-receptor stimulation enhanced both IP3 and prostaglandin-E(2) production.	Inositol triphosphate	31-52	endothelin receptor type A	Homo sapiens	0-3
11375128-5	2001	Both trypsin and thrombin were shown to activate phospholipase C, as measured by an increase in inositol triphosphate turnover by adrenal capsular tissue.	Inositol triphosphate	96-117	coagulation factor II	Rattus norvegicus	17-25
11171601-0	2001	Desensitization of angiotensin II: effect on [Ca2+]i, inositol triphosphate, and prolactin in pituitary cells.	Inositol triphosphate	54-75	angiotensinogen	Rattus norvegicus	19-33
11171601-8	2001	ANG II pretreatment also desensitized ANG II- and TRH-induced inositol phosphate generation (72.8 +/- 3.5 and 69.6 +/- 6.1%, respectively, for inositol triphosphate) and prolactin secretion (53.4 +/- 2.3 and 65.1 +/- 7.2%), effects independent of PKC activation.	Inositol triphosphate	143-164	angiotensinogen	Rattus norvegicus	0-6
11171601-8	2001	ANG II pretreatment also desensitized ANG II- and TRH-induced inositol phosphate generation (72.8 +/- 3.5 and 69.6 +/- 6.1%, respectively, for inositol triphosphate) and prolactin secretion (53.4 +/- 2.3 and 65.1 +/- 7.2%), effects independent of PKC activation.	Inositol triphosphate	143-164	angiotensinogen	Rattus norvegicus	38-44
11171601-9	2001	We conclude that, in pituitary cells, inositol triphosphate formation, [Ca2+](i) mobilization, and prolactin release in response to ANG II undergo rapid, long-lasting, homologous and heterologous desensitization.	Inositol triphosphate	38-59	angiotensinogen	Rattus norvegicus	132-138
11333532-3	2001	The 5-HT2 receptor family includes the subtype 5-HT2A, a G protein coupled receptor whose activation leads to the stimulation of the enzyme phospholipase C and to the subsequent hydrolysis of the membrane located phosphoinositides, with the synthesis of the second messengers inositol triphosphate and diacylglicerol.	Inositol triphosphate	276-297	5-hydroxytryptamine receptor 2A	Homo sapiens	47-53
10799761-6	2000	The neurotensin-evoked intracellular Ca(2+) accumulation is blocked by the phospholipase C inhibitor U73122 and by thapsigargin, suggesting that it is initiated by release of Ca(2+) from an inositol triphosphate-dependent store.	Inositol triphosphate	190-211	neurotensin	Rattus norvegicus	4-15
11158922-3	2001	PTH and PTH-RP (10(-8) M) raised cAMP and inositol-triphosphate release by dispersed adrenocortical cells, and these effects were blocked by the adenylate cyclase inhibitor SQ-22536 (10(-4) M) and the phospholipase C (PLC) inhibitor U-73122 (10(-5) M), respectively.	Inositol triphosphate	42-63	parathyroid hormone	Homo sapiens	0-3
11158922-3	2001	PTH and PTH-RP (10(-8) M) raised cAMP and inositol-triphosphate release by dispersed adrenocortical cells, and these effects were blocked by the adenylate cyclase inhibitor SQ-22536 (10(-4) M) and the phospholipase C (PLC) inhibitor U-73122 (10(-5) M), respectively.	Inositol triphosphate	42-63	parathyroid hormone like hormone	Homo sapiens	8-14
10976994-10	2000	Comparison of the signaling pathways required for 0.33 Hz PIS and IL-1beta-induced membrane hyperpolarization shows that both involve the phospholipase C/inositol triphosphate pathway, protein kinase C (PKC), and prostaglandin synthesis.	Inositol triphosphate	154-175	interleukin 1 beta	Homo sapiens	66-74
10839927-5	2000	Potassium chloride (KCl; 100 mm) was used to depolarize and activate Ca2+ entry through voltage-dependent calcium channels; 1 mm carbachol was used to activate muscarinic receptor-mediated inositol triphosphate (IP3)-dependent intracellular Ca2+ release.	Inositol triphosphate	189-210	carbonic anhydrase 2	Homo sapiens	241-244
10905621-2	2000	The activation of pertussis toxin-sensitive G-proteins linked to PAF receptors results in the mobilization of intracellular calcium, at least in part, through the second messenger inositol triphosphate.	Inositol triphosphate	180-201	PCNA clamp associated factor	Homo sapiens	65-68
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Inositol triphosphate	120-141	carbonic anhydrase 2	Homo sapiens	55-58
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Inositol triphosphate	120-141	carbonic anhydrase 2	Homo sapiens	102-105
10839927-10	2000	These data suggest the involvement of an intracellular Ca2+ translocation from the caffeine-sensitive Ca2+ store to the inositol triphosphate-sensitive Ca2+ store that was altered by halothane and isoflurane.	Inositol triphosphate	120-141	carbonic anhydrase 2	Homo sapiens	102-105
10749940-1	2000	The engagement of integrin alpha7 in E63 skeletal muscle cells by laminin or anti-alpha7 antibodies triggered transient elevations in the intracellular free Ca(2+) concentration that resulted from both inositol triphosphate-evoked Ca(2+) release from intracellular stores and extracellular Ca(2+) influx through voltage-gated, L-type Ca(2+) channels.	Inositol triphosphate	202-223	integrin subunit alpha 7	Rattus norvegicus	18-33
9928026-6	1998	PACAP is present in the ARC, PVN, and SCH, and its hypothalamic type I receptor elevates cAMP and inositol triphosphate in the PVN, where it may perhaps antagonize NPY-induced food intake and hyperinsulinemia.	Inositol triphosphate	98-119	adenylate cyclase activating polypeptide 1	Homo sapiens	0-5
10613618-10	1999	Clomipramine and fluoxetine treatments, which further decreased the density of 5-HTT sites, allowed platelet inositol triphosphate levels to return to normal values only in responders.	Inositol triphosphate	109-130	solute carrier family 6 member 4	Homo sapiens	79-84
10577520-7	1999	Cross-linking of CD163 with monoclonal antibody induced a protein tyrosine kinase-dependent signal that resulted in (1) slow-type calcium mobilization, (2) inositol triphosphate production, and (3) secretion of IL-6 and GM-CSF.	Inositol triphosphate	156-177	CD163 molecule	Homo sapiens	17-22
10394997-1	1999	RATIONALE: Myo-inositol is an isomer of glucose that is a precursor in the phosphatidylinositol (PIP) cycle, a source of two second messengers: diacylglycerol (DAG) and inositol triphosphate (IP3).	Inositol triphosphate	169-190	prolactin induced protein	Homo sapiens	97-100
9927281-3	1999	Oxytocin (OT) is one of the main regulators of uterine activity, acting via activation of the inositol triphosphate pathway.	Inositol triphosphate	94-115	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
9927281-3	1999	Oxytocin (OT) is one of the main regulators of uterine activity, acting via activation of the inositol triphosphate pathway.	Inositol triphosphate	94-115	oxytocin/neurophysin I prepropeptide	Homo sapiens	10-12
10467229-5	1999	This receptor is coupled to the G-protein Gq, which mediates AngII-induced inositol triphosphate (IP3) formation.	Inositol triphosphate	75-96	angiotensinogen	Homo sapiens	61-66
10082522-3	1999	GnRH stimulation of gonadotropin expression and secretion occurs through the G-protein-linked phospholipase C/inositol triphosphate intracellular signaling pathway, which ultimately leads to protein kinase C (PKC) activation and increased intracellular calcium levels.	Inositol triphosphate	110-131	gonadotropin releasing hormone 1	Homo sapiens	0-4
10100621-4	1999	This tyrosine phosphorylation of PLC-gamma1 caused the increment of the intracellular inositol triphosphate (IP3) levels in L6 myoblasts.	Inositol triphosphate	86-107	phospholipase C gamma 1	Homo sapiens	33-43
9826785-4	1998	PACAP type I receptors can activate adenylate cyclase and stimulate phospholipase C through heterotrimeric G protein interactions, leading to increased intracellular cyclic AMP (cAMP), inositol triphosphate (IP3)-mediated calcium mobilization, and calcium- and diacylglycerol (DAG)-mediated protein kinase C (PKC) activation.	Inositol triphosphate	185-206	adenylate cyclase activating polypeptide 1	Bos taurus	0-5
9745951-7	1998	PMCA 2 is the isoform with the highest affinity for calmodulin, and has also been associated with high levels of inositol triphosphate.	Inositol triphosphate	113-134	ATPase plasma membrane Ca2+ transporting 2	Rattus norvegicus	0-6
9870661-9	1998	Inositol triphosphate (IP3) production was also severely reduced in Btk-deficient mast cells, indicating Btk play a critical role of Fc epsilonRI-induced IP3 production.	Inositol triphosphate	0-21	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	68-71
9870661-9	1998	Inositol triphosphate (IP3) production was also severely reduced in Btk-deficient mast cells, indicating Btk play a critical role of Fc epsilonRI-induced IP3 production.	Inositol triphosphate	0-21	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	105-108
9870661-9	1998	Inositol triphosphate (IP3) production was also severely reduced in Btk-deficient mast cells, indicating Btk play a critical role of Fc epsilonRI-induced IP3 production.	Inositol triphosphate	0-21	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	133-145
9032562-2	1996	Extracellular administration of inositol triphosphate (10(-6) mol/l) or calcium ions (10(-4) mol/l) mimics the action of both arginine-vasopressin and LH/FSH and evokes progesterone secretion in superfused granulosa cells.	Inositol triphosphate	32-53	arginine vasopressin	Homo sapiens	135-146
9588758-1	1998	Lithium inhibits the enzyme inositol monophosphatase and thus obstructs the enzymatic degradation of inositol triphosphate (IP3) to inositol in the phosphate-phosphoinositide (PIP) cycle.	Inositol triphosphate	101-122	prolactin induced protein	Homo sapiens	176-179
9288154-8	1997	RESULTS: We have shown that (1) AR42J cells respond to PACAP-38 with biphasic increases in [Ca2+]i in a dose-dependent fashion; (2) PACAP-38 acts through phospholipase C to release inositol triphosphate (IP3)-sensitive Ca2+ stores with (3) a subsequent influx of extracellular Ca2+.	Inositol triphosphate	181-202	adenylate cyclase activating polypeptide 1	Rattus norvegicus	55-60
9288154-8	1997	RESULTS: We have shown that (1) AR42J cells respond to PACAP-38 with biphasic increases in [Ca2+]i in a dose-dependent fashion; (2) PACAP-38 acts through phospholipase C to release inositol triphosphate (IP3)-sensitive Ca2+ stores with (3) a subsequent influx of extracellular Ca2+.	Inositol triphosphate	181-202	adenylate cyclase activating polypeptide 1	Rattus norvegicus	132-137
9647226-4	1998	One such substrate, phospholipase C (PLC)-gamma1, becomes tyrosine phosphorylated on CD3/TCR activation and mediates inositol triphosphate-dependent Ca2+ flux.	Inositol triphosphate	117-138	phospholipase C gamma 1	Homo sapiens	20-48
9647226-4	1998	One such substrate, phospholipase C (PLC)-gamma1, becomes tyrosine phosphorylated on CD3/TCR activation and mediates inositol triphosphate-dependent Ca2+ flux.	Inositol triphosphate	117-138	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	89-92
9658171-3	1998	We recently reported that dIgA binding to the pIgR induces translocation of protein kinase C, production of inositol triphosphate, and elevation of intracellular free calcium.	Inositol triphosphate	108-129	polymeric immunoglobulin receptor	Homo sapiens	46-50
9618465-6	1998	COS cells transiently transfected with PAR4 resulted in the formation of intracellular inositol triphosphate when treated with either thrombin or trypsin.	Inositol triphosphate	87-108	F2R like thrombin or trypsin receptor 3	Homo sapiens	39-43
9618465-6	1998	COS cells transiently transfected with PAR4 resulted in the formation of intracellular inositol triphosphate when treated with either thrombin or trypsin.	Inositol triphosphate	87-108	coagulation factor II, thrombin	Homo sapiens	134-142
9651535-9	1998	mGluR1 and mGluR5 are both coupled to inositol triphosphate (IP3)/calcium signal transduction with an identical agonist selectivity.	Inositol triphosphate	38-59	glutamate metabotropic receptor 1	Homo sapiens	0-6
9651535-9	1998	mGluR1 and mGluR5 are both coupled to inositol triphosphate (IP3)/calcium signal transduction with an identical agonist selectivity.	Inositol triphosphate	38-59	glutamate receptor, ionotropic, kainate 1	Mus musculus	11-17
8688470-5	1996	A human kidney cell line (293), stably transfected with this vector, expressed the receptor at a high level and, when challenged with human PTH(1-34), increased cytoplasmic cAMP and inositol triphosphate production.	Inositol triphosphate	182-203	parathyroid hormone	Homo sapiens	140-143
9604776-6	1996	Gp120 is able to rise intracellular calcium concentration and to induce the formation of inositol triphosphate, can block mitogen- or antigen-driven T cell activation, can induce altered cytokine production by activated PBMC subpopulations, determines impaired cytotoxicity and chemotactic response to antigens, interferes with the activity of antigen presenting cells, enhances or induces apoptosis, stimulates polyclonal B cell activation and induces or up-modulates a number of cytokines, including IL-6.	Inositol triphosphate	89-110	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-5
8599832-1	1996	The interaction between IL-16 and its receptor CD4 leads to an increase in intracytoplasmic calcium and inositol triphosphate.	Inositol triphosphate	104-125	interleukin 16	Homo sapiens	24-29
8599832-1	1996	The interaction between IL-16 and its receptor CD4 leads to an increase in intracytoplasmic calcium and inositol triphosphate.	Inositol triphosphate	104-125	CD4 molecule	Homo sapiens	47-50
9046355-3	1996	We observed that, whereas oxytocin and PAF activated the phosphoinositide cycle, generating inositol triphosphate to mobilize intracellular Ca2+, PGF2 alpha acted mainly to enhance Ca2+ influx.	Inositol triphosphate	92-113	PCNA clamp associated factor	Homo sapiens	39-42
8722501-6	1996	However, we found alpha-trinositol to inhibit the rise in intracellular Ca2+ as well as inositol triphosphate concentrations induced by neuropeptide Y.	Inositol triphosphate	88-109	neuropeptide Y	Homo sapiens	136-150
8838148-11	1996	We conclude that TRH stimulation of TSH beta gene transcription requires Ca2+ release from inositol triphosphate-sensitive stores and Ca2+ influx via L-type calcium channels in GH3 cells, but in transfected 293 cells TRH activation of protein kinase C plays a predominant role in activating TSH beta.	Inositol triphosphate	91-112	thyroid stimulating hormone subunit beta	Rattus norvegicus	36-44
8777586-5	1995	When cells are stimulated with a ligand for a receptor, such as ATP or PDGF, PLC is activated via either a G protein-dependent or -independent process, leading to the production of diacylglycerol (DAG) and inositol triphosphate (IP3).	Inositol triphosphate	206-227	heparan sulfate proteoglycan 2	Homo sapiens	77-80
8576426-1	1995	The metabotropic glutamate receptor mGluR5 is a G-protein coupled receptor that plays a key role in release of Ca2+ from internal stores via inositol triphosphate mobilization.	Inositol triphosphate	141-162	glutamate receptor, ionotropic, kainate 1	Mus musculus	36-42
8567063-3	1995	Prompt increases in inositol triphosphate (IP3) formation and [Ca2+]i were observed upon the addition of ET-1 to these cells.	Inositol triphosphate	20-41	endothelin 1	Rattus norvegicus	105-109
8589287-9	1995	Angiotensin II stimulated inositol triphosphate release, and this effect could be blocked by the phospholipase C inhibitor U73122, suggesting a role of phospholipase C or A2 in this effect of angiotensin II.	Inositol triphosphate	26-47	LOC100009319	Oryctolagus cuniculus	97-112
8589287-9	1995	Angiotensin II stimulated inositol triphosphate release, and this effect could be blocked by the phospholipase C inhibitor U73122, suggesting a role of phospholipase C or A2 in this effect of angiotensin II.	Inositol triphosphate	26-47	LOC100009319	Oryctolagus cuniculus	152-167
7672512-8	1995	Upon binding of ET-1 to ETA, phospholipase C is activated and inositol triphosphate is generated.	Inositol triphosphate	62-83	endothelin 1	Homo sapiens	16-27
7972134-8	1994	The present results indicate that nicotine-induced stimulation of alpha-MSH release in frog melanotrophs can be explained by activation of inositolphospholipid breakdown and mobilization of inositol triphosphate-dependent intracellular Ca2+ pools.	Inositol triphosphate	190-211	proopiomelanocortin	Homo sapiens	66-75
7541915-6	1995	Inhibition of cAMP-mediated secretion (by VIP, secretin, or PACAP) occurred at lower concentrations than with inositol triphosphate (IP3)/Ca(2+)-dependent enzyme release (via CCK).	Inositol triphosphate	110-131	cholecystokinin	Rattus norvegicus	175-178
7705461-2	1994	Endothelin-1 induced a rapid increase in inositol triphosphate (IP3) formation in these cells, whereas endothelin-3 was only moderately effective at high concentrations.	Inositol triphosphate	41-62	endothelin 1	Rattus norvegicus	0-12
7891778-0	1995	Heat-aggregated IgA prepared from patients with IgA nephropathy increases priming of human neutrophils to produce inositol triphosphate following FMet-Leu-Phe stimulation in vitro.	Inositol triphosphate	114-135	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	16-19
7891778-0	1995	Heat-aggregated IgA prepared from patients with IgA nephropathy increases priming of human neutrophils to produce inositol triphosphate following FMet-Leu-Phe stimulation in vitro.	Inositol triphosphate	114-135	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	48-51
7891778-0	1995	Heat-aggregated IgA prepared from patients with IgA nephropathy increases priming of human neutrophils to produce inositol triphosphate following FMet-Leu-Phe stimulation in vitro.	Inositol triphosphate	114-135	formyl peptide receptor 1	Homo sapiens	146-158
8250951-5	1993	TRH-stimulated inositol triphosphate (IP3) production was rather augmented by the replacement with high Mg2+ medium.	Inositol triphosphate	15-36	thyrotropin releasing hormone	Rattus norvegicus	0-3
7976660-2	1994	ET-1 also induced transient accumulation of inositol triphosphate (IP3) and release of [3H] arachidonic acid (AA) from HBEC.	Inositol triphosphate	44-65	endothelin 1	Homo sapiens	0-4
8282327-1	1994	Recently, we demonstrated that glucocorticoid potentiates inositol triphosphate production evoked by angiotensin II in vascular smooth muscle cells.	Inositol triphosphate	58-79	angiotensinogen	Homo sapiens	101-115
8083470-3	1994	On stimulation with IL-4, the generation of inositol triphosphate was observed in the cells.	Inositol triphosphate	44-65	interleukin 4	Homo sapiens	20-24
8083470-5	1994	Although herbimycin A, a potent inhibitor of tryosine kinase, inhibited IL-4-induced activation of PLC-gamma 1 and generation of inositol triphosphate, direct phosphorylation of PCL-gamma 1 was not determined.	Inositol triphosphate	129-150	interleukin 4	Homo sapiens	72-76
8117446-8	1994	Moreover, PAF transiently increased inositol triphosphate (IP3) levels, peaking 10 s after addition.	Inositol triphosphate	36-57	PCNA-associated factor	Bos taurus	10-13
8404621-5	1993	ET-1 induced both rapid production of inositol triphosphate and mobilization of [Ca2+]i in a concentration-dependent fashion.	Inositol triphosphate	38-59	endothelin 1	Rattus norvegicus	0-4
8498970-3	1993	Angiotensin II (Ang II) causes (AT1)-receptor mediated stimulation of phospholipase C, resulting in generation of IP3 (inositol triphosphate) and activation of protein kinase C, elevated cytosolic Ca+ and stimulation phospholipase A2.	Inositol triphosphate	119-140	angiotensinogen	Homo sapiens	0-14
8492147-13	1993	Pretreatment with Li+ significantly enhanced the I5-HT, indicating that I5-HT is involved in the elevation of intracellular free Ca2+ released from inositol triphosphate (IP3)-sensitive Ca2+ store sites but not from the caffeine-sensitive ones.	Inositol triphosphate	148-169	carbonic anhydrase 2	Rattus norvegicus	129-132
8492147-13	1993	Pretreatment with Li+ significantly enhanced the I5-HT, indicating that I5-HT is involved in the elevation of intracellular free Ca2+ released from inositol triphosphate (IP3)-sensitive Ca2+ store sites but not from the caffeine-sensitive ones.	Inositol triphosphate	148-169	carbonic anhydrase 2	Rattus norvegicus	186-189
8388084-8	1993	In recombinant human nerve growth factor-treated animals, inositol triphosphate production was similar to values on unlesioned control sides.	Inositol triphosphate	58-79	nerve growth factor	Homo sapiens	21-40
8388084-10	1993	In animals with full unilateral fimbrial transections, oxotremorine-induced inositol triphosphate production was increased by 99% on the lesioned side of animals treated with a control protein and treatment with recombinant human nerve growth factor did not alter this denervation-induced supersensitivity of muscarinic receptor transduction signal.	Inositol triphosphate	76-97	nerve growth factor	Homo sapiens	230-249
8392097-7	1993	The TNF + LiCl-induced increase in inositol triphosphate suggests a role for intracellular Ca2+ mobilization in TNF action.	Inositol triphosphate	35-56	tumor necrosis factor	Mus musculus	4-7
8392097-7	1993	The TNF + LiCl-induced increase in inositol triphosphate suggests a role for intracellular Ca2+ mobilization in TNF action.	Inositol triphosphate	35-56	tumor necrosis factor	Mus musculus	112-115
8498970-3	1993	Angiotensin II (Ang II) causes (AT1)-receptor mediated stimulation of phospholipase C, resulting in generation of IP3 (inositol triphosphate) and activation of protein kinase C, elevated cytosolic Ca+ and stimulation phospholipase A2.	Inositol triphosphate	119-140	angiotensinogen	Homo sapiens	16-22
1456175-5	1992	Moreover, levels of the second messenger, inositol triphosphate (IP3), were significantly delayed in chlordane-treated animals following interaction with IFN/LPS.	Inositol triphosphate	42-63	toll-like receptor 4	Mus musculus	154-161
1628211-9	1992	Inositol biphosphate (IP2) and inositol triphosphate (IP3) in RPE cells showed transient increases at 15 s after the stimulation by bombesin-related peptides.	Inositol triphosphate	31-52	gastrin releasing peptide	Homo sapiens	132-140
1917391-9	1991	In addition, FBS, bFGF, and PDGF increased the contents of inositol phosphate, inositol biphosphate, and inositol triphosphate (IP3) in RPE cells slowly up to 60 min except that PDGF showed a peak of IP3 at 15 min after stimulation.	Inositol triphosphate	105-126	fibroblast growth factor 2	Homo sapiens	18-22
1585373-2	1992	EGF causes an increase in Ca2+ influx and accumulation of inositol triphosphate and probably exhibits many, if not all, of its effects via the calcium messenger system.	Inositol triphosphate	58-79	epidermal growth factor like 1	Rattus norvegicus	0-3
1559768-10	1992	(5) NPY (10(-6)M) significantly increased the formation of inositol triphosphate following a 15 sec exposure.	Inositol triphosphate	59-80	neuropeptide Y	Bos taurus	4-7
1310640-12	1992	Evaluation of biological activity mediated by the muscarinic cholinergic and bombesin receptors revealed an increase of intracellular calcium and of inositol triphosphate by specific receptor agonists.	Inositol triphosphate	149-170	gastrin releasing peptide	Homo sapiens	77-85
1309338-5	1992	One hundred nanomolar CT also produced a slight but significant increase in inositol triphosphate production (13%, P less than 0.05) but did not produce a rapid, transient increase in [Ca2+]i.	Inositol triphosphate	76-97	calcitonin-related polypeptide alpha	Rattus norvegicus	22-24
1309338-7	1992	This stimulatory effect of PTH on [Ca2+]i signal was dose-dependent and accompanied by a parallel stimulation of inositol triphosphate production.	Inositol triphosphate	113-134	parathyroid hormone	Rattus norvegicus	27-30
1987767-3	1991	It is shown for the first time that guinea pig VPF (half-maximal and maximal dose approximately 0.4 and 22 pmol/l (picomolar), respectively), as well as human VPF, are potent stimuli for human ECs resulting in [Ca2+]i increases (maximal three- to fourfold) and inositol triphosphate (IP3) formation.	Inositol triphosphate	261-282	vascular endothelial growth factor A	Homo sapiens	47-50
1832571-2	1991	We demonstrate that the inhibition, linked to blockade of the [Ca2+]i rise involving T cell receptor (TCR) triggering, resulted from the action of these compounds on the signal transduction pathway, upstream from inositol triphosphate synthesis.	Inositol triphosphate	213-234	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	85-100
1832571-2	1991	We demonstrate that the inhibition, linked to blockade of the [Ca2+]i rise involving T cell receptor (TCR) triggering, resulted from the action of these compounds on the signal transduction pathway, upstream from inositol triphosphate synthesis.	Inositol triphosphate	213-234	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	102-105
1987767-3	1991	It is shown for the first time that guinea pig VPF (half-maximal and maximal dose approximately 0.4 and 22 pmol/l (picomolar), respectively), as well as human VPF, are potent stimuli for human ECs resulting in [Ca2+]i increases (maximal three- to fourfold) and inositol triphosphate (IP3) formation.	Inositol triphosphate	261-282	vascular endothelial growth factor A	Homo sapiens	159-162
2110278-4	1990	In thrombin-activated WPs with calcium, the increase of intracellular calcium concentration, [Ca2+]i, and the production of inositol triphosphate (IP3) were dose-dependently inhibited by calpeptin.	Inositol triphosphate	124-145	coagulation factor II, thrombin	Homo sapiens	3-11
1838253-9	1991	Treatment of cells known to activate the protein kinase C (TPA) and inositol triphosphate pathways has increased the level of beta-MHC mRNA while that of alpha-MHC remained unchanged.	Inositol triphosphate	68-89	major histocompatibility complex, class I, C	Homo sapiens	131-134
1691437-5	1990	PLC-mediated production of radioactive inositol monophosphate, inositol diphosphate, and inositol triphosphate was monitored.	Inositol triphosphate	89-110	LOC100009319	Oryctolagus cuniculus	0-3
2190817-5	1990	This appeared to be due to epinephrine recoupling thrombin receptors to phospholipase C. In support of this, epinephrine was able to induce the formation of inositol triphosphate when added after the response to thrombin had also become desensitized.	Inositol triphosphate	157-178	coagulation factor II, thrombin	Homo sapiens	50-58
34388674-6	2021	The up-regulation of Ca2+ was induced by inositol triphosphate (IP3) via its specific IP3 receptor.	Inositol triphosphate	41-62	carbonic anhydrase 2	Homo sapiens	21-24
34388674-6	2021	The up-regulation of Ca2+ was induced by inositol triphosphate (IP3) via its specific IP3 receptor.	Inositol triphosphate	41-62	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-98
34642458-4	2022	Here, we found that through the integration of synaptic inputs, astrocyte inositol triphosphate (IP3) receptor type 2 (IP3R2)-dependent Ca2+ signaling was critical for late-phase LTP (L-LTP) but not early-phase LTP (E-LTP).	Inositol triphosphate	74-95	inositol 1,4,5-trisphosphate receptor type 2	Homo sapiens	119-124
34547325-4	2021	According to Western Blot (WB) results, Glu treatment resulted in a high level of large-conductance Ca2+- and voltage-activated K+ (BK) channels, with activation relying on the mGluR5-IP3R (inositol triphosphate) pathway.	Inositol triphosphate	190-211	glutamate receptor, ionotropic, kainate 1	Mus musculus	177-183
34547325-4	2021	According to Western Blot (WB) results, Glu treatment resulted in a high level of large-conductance Ca2+- and voltage-activated K+ (BK) channels, with activation relying on the mGluR5-IP3R (inositol triphosphate) pathway.	Inositol triphosphate	190-211	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	184-188
34630662-9	2021	Treatment was revealed to attenuate the decreased expression of the Sigma-1 receptor and increase the expression of inositol triphosphate type 2 receptors (IP3R2) in MI rats.	Inositol triphosphate	116-137	inositol 1,4,5-trisphosphate receptor, type 2	Rattus norvegicus	156-161
2556506-0	1989	Cross-communication between acetylcholine and VIP in controlling catecholamine secretion by affecting cAMP, inositol triphosphate, protein kinase C, and calcium in rat adrenal medulla.	Inositol triphosphate	108-129	vasoactive intestinal peptide	Rattus norvegicus	46-49
34252911-2	2022	It is known that activation of mGluR1/5 results in production of inositol triphosphate (IP3) and diacylglycerol (DAG) that leads to activation of extracellular signal-regulated kinases (ERK1/2) and an increase in neuronal excitability, but how mGluR1/5 mediate this process remains unclear.	Inositol triphosphate	65-86	glutamate receptor, metabotropic 1	Mus musculus	31-39
34252911-2	2022	It is known that activation of mGluR1/5 results in production of inositol triphosphate (IP3) and diacylglycerol (DAG) that leads to activation of extracellular signal-regulated kinases (ERK1/2) and an increase in neuronal excitability, but how mGluR1/5 mediate this process remains unclear.	Inositol triphosphate	65-86	mitogen-activated protein kinase 3	Mus musculus	186-192
34252911-2	2022	It is known that activation of mGluR1/5 results in production of inositol triphosphate (IP3) and diacylglycerol (DAG) that leads to activation of extracellular signal-regulated kinases (ERK1/2) and an increase in neuronal excitability, but how mGluR1/5 mediate this process remains unclear.	Inositol triphosphate	65-86	glutamate receptor, metabotropic 1	Mus musculus	244-252
35182526-0	2022	Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/ TFE3.	Inositol triphosphate	0-21	transcription factor EB	Homo sapiens	111-115
35182526-0	2022	Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/ TFE3.	Inositol triphosphate	0-21	transcription factor binding to IGHM enhancer 3	Homo sapiens	117-121
35182526-5	2022	We show using functional imaging that calcium efflux from ER stores induced by inositol-triphosphate (IP3) accumulation upon depletion of INPP5A, an inositol 5-phosphatase downregulated in cancer and defective in spinocerebellar ataxia, or receptor-mediated phospholipase C activation leads to the induction of lysosome biogenesis.	Inositol triphosphate	79-100	inositol polyphosphate-5-phosphatase A	Homo sapiens	138-144
2698762-3	1989	In the early stage of insulin secretion in particular the intracellular compartment is the source of calcium; from there the ion is released due to the action of inositol triphosphate (IP3) activated by phospholipase C. Calcium of the extracellular compartment is mobilized also in the early secretory stage by opening of the depolarization-dependent calcium channels, it plays, however, a more important part during the second stage.	Inositol triphosphate	162-183	insulin	Homo sapiens	22-29
2549060-2	1989	In cells that were pretreated with EGF for 30 min at 37 degrees C and then washed to remove surface-bound hormone, a 70-100% decrease in the EGF-stimulated production of inositol monophosphate, inositol bisphosphate, and inositol triphosphate was noted when the cells were exposed to the agonist a second time.	Inositol triphosphate	221-242	epidermal growth factor	Homo sapiens	35-38
2549060-2	1989	In cells that were pretreated with EGF for 30 min at 37 degrees C and then washed to remove surface-bound hormone, a 70-100% decrease in the EGF-stimulated production of inositol monophosphate, inositol bisphosphate, and inositol triphosphate was noted when the cells were exposed to the agonist a second time.	Inositol triphosphate	221-242	epidermal growth factor	Homo sapiens	141-144
2548897-0	1989	[Effect of vasopressin on the osmotic permeability of the bladder wall in the frog and its content of cAMP, cGMP and inositol triphosphate].	Inositol triphosphate	117-138	arginine vasopressin	Homo sapiens	11-22
2788303-2	1989	The binding of mitogenic lectins phytohaemagglutinin (PHA), concanavalin A (Con A) and/or of monoclonal antibodies to different receptors such as antigen receptor complex or CD2 on human T cells generates increases in the concentrations of inositol triphosphate (IP3) and cytoplasmic free calcium.	Inositol triphosphate	240-261	CD2 molecule	Homo sapiens	174-177
2678953-2	1989	Addition of human r-IL-1 to human synovial cells in culture stimulated phospholipase A2 (PLA2) activity, inositol triphosphate production and plasminogen activator (PA) activity in a dose dependent manner with similar EC50 values (0.1-0.5 nM).	Inositol triphosphate	105-126	interleukin 1 alpha	Homo sapiens	20-24
2548897-3	1989	The sharp increase of inositol triphosphate content was observed within 20 sec after vasopressin administration, whereas cGMP content significantly decreased within 5 min.	Inositol triphosphate	22-43	arginine vasopressin	Homo sapiens	85-96
2548897-4	1989	The augmentation of cAMP content seems to lead to a rise in water permeability white inositol triphosphate and cGMP acted, probably, as modulators of the vasopressin effect.	Inositol triphosphate	85-106	arginine vasopressin	Homo sapiens	154-165
2844096-8	1988	These studies indirectly suggest that the adenosine 3",5"-cyclic monophosphate system and the inositol triphosphate system are involved in ANP secretion, with the former responsible for the initial rapid release and the latter maintaining the secretion.	Inositol triphosphate	94-115	natriuretic peptide A	Rattus norvegicus	139-142
2829912-13	1988	59, 353-366 (1977)] inhibit the stimulation by vasopressin of inositol utilization without significantly affecting coupling between hormone receptors and adenyl cyclase or phosphoinositide-specific phosphodiesterase, the action of the phosphodiesterase, and the degradation of inositol triphosphate.	Inositol triphosphate	277-298	arginine vasopressin	Homo sapiens	47-58
2967696-0	1988	Guanine nucleotide-, and inositol triphosphate-induced inhibition of the CA2+ pump in rat heart sarcolemmal vesicles.	Inositol triphosphate	25-46	carbonic anhydrase 2	Rattus norvegicus	73-76
2827073-5	1987	The previously described potentiation of the alpha 1-adrenoceptor-mediated contractile responses of the rodent vas deferens by adenosine and NPY is suggested to result from an enhanced alpha 1-adrenoceptor-induced accumulation of inositol triphosphate.	Inositol triphosphate	230-251	neuropeptide Y	Rattus norvegicus	141-144
3040912-1	1987	The association of neurotensin to its receptor in differentiated neuroblastoma N1E115 cells led to a fast and transitory increase of the intracellular concentration in inositol triphosphate and inositol biphosphate, followed by a slower and more stable increase inositol monophosphate.	Inositol triphosphate	168-189	neurotensin	Mus musculus	19-30
3040912-3	1987	Therefore, the cyclic GMP stimulation is probably a consequence of the initial inositol triphosphate formation triggered by neurotensin.	Inositol triphosphate	79-100	5'-nucleotidase, cytosolic II	Mus musculus	22-25
3040912-3	1987	Therefore, the cyclic GMP stimulation is probably a consequence of the initial inositol triphosphate formation triggered by neurotensin.	Inositol triphosphate	79-100	neurotensin	Mus musculus	124-135
3040912-4	1987	Fluoroaluminate ions and pertussis toxin had the capacity to modulate positively and negatively, respectively, the formation of inositol triphosphate induced by neurotensin, indicating that GTP-binding proteins are involved in the regulation of inositol phosphate levels by neurotensin receptors.	Inositol triphosphate	128-149	neurotensin	Mus musculus	161-172
3040912-4	1987	Fluoroaluminate ions and pertussis toxin had the capacity to modulate positively and negatively, respectively, the formation of inositol triphosphate induced by neurotensin, indicating that GTP-binding proteins are involved in the regulation of inositol phosphate levels by neurotensin receptors.	Inositol triphosphate	128-149	neurotensin	Mus musculus	274-285
3036863-1	1987	In a crude membrane preparation of rat 7315c cells, GTP was found to enhance thyrotropin-releasing hormone- (TRH) stimulated inositol triphosphate (IP3) formation with a potency of 0.97 +/- 0.1 microM.	Inositol triphosphate	125-146	thyrotropin releasing hormone	Rattus norvegicus	77-106
3036863-1	1987	In a crude membrane preparation of rat 7315c cells, GTP was found to enhance thyrotropin-releasing hormone- (TRH) stimulated inositol triphosphate (IP3) formation with a potency of 0.97 +/- 0.1 microM.	Inositol triphosphate	125-146	thyrotropin releasing hormone	Rattus norvegicus	109-112
3596955-4	1987	The authors interpret these results with reference to the main mechanism of the membrane signal triggered by PAF, namely the activation of phosphatidylinositol cycle with the formation of inositol-triphosphate, the inhibition of the light-induced response of the retina by administration of inositol-triphosphate, and the antagonistic effect of GBE and BN 52021 on specific PAF-receptors demonstrated on other models.	Inositol triphosphate	188-209	PCNA clamp associated factor	Rattus norvegicus	109-112
2433285-4	1987	First, EGF stimulated the breakdown of phosphatidylinositol 4,5-diphosphate to diacylglycerol and an inositol triphosphate.	Inositol triphosphate	101-122	epidermal growth factor	Homo sapiens	7-10
2433285-6	1987	The EGF-dependent increases in both inositol triphosphate production and phosphatidylinositol 4-monophosphate levels were inhibited by pretreatment of the cells with 12-O-tetradecanoylphorbol-13-acetate.	Inositol triphosphate	36-57	epidermal growth factor	Homo sapiens	4-7
2433285-10	1987	These data demonstrate that EGF stimulates the production of inositol triphosphate.	Inositol triphosphate	61-82	epidermal growth factor	Homo sapiens	28-31
3596955-4	1987	The authors interpret these results with reference to the main mechanism of the membrane signal triggered by PAF, namely the activation of phosphatidylinositol cycle with the formation of inositol-triphosphate, the inhibition of the light-induced response of the retina by administration of inositol-triphosphate, and the antagonistic effect of GBE and BN 52021 on specific PAF-receptors demonstrated on other models.	Inositol triphosphate	291-312	PCNA clamp associated factor	Rattus norvegicus	109-112
3015563-2	1986	In the present study, we demonstrate that vasopressin (VP) stimulates the formation of inositol monophosphate (IP), inositol diphosphate (IP2) and inositol triphosphate (IP3) in primary cultures of glomerulosa as well as fasciculata cells 5- to 8-fold over the corresponding basal values.	Inositol triphosphate	147-168	arginine vasopressin	Homo sapiens	42-53
3121934-10	1987	Addition of gonadotropin-releasing hormone to myo-2[3H]inositol-prelabeled rat pituitary cells in primary culture evoked a dose-dependent increase of the accumulation of [3H]inositol phosphates with a rise of inositol triphosphate, inositol diphosphate and inositol monophosphate within 1 min.	Inositol triphosphate	209-230	gonadotropin releasing hormone 1	Rattus norvegicus	12-42
3017954-3	1986	GTP gamma S (10 microM) plus thrombin (1 unit/ml) stimulated the release of inositol triphosphate, inositol diphosphate, and inositol phosphate 500, 300, and 250%, respectively, compared to GTP gamma S alone.	Inositol triphosphate	76-97	coagulation factor II, thrombin	Homo sapiens	29-37
3015563-2	1986	In the present study, we demonstrate that vasopressin (VP) stimulates the formation of inositol monophosphate (IP), inositol diphosphate (IP2) and inositol triphosphate (IP3) in primary cultures of glomerulosa as well as fasciculata cells 5- to 8-fold over the corresponding basal values.	Inositol triphosphate	147-168	arginine vasopressin	Homo sapiens	55-57
3015130-2	1986	In the presence of GTP gamma S, thrombin increased the release of inositol triphosphate and inositol biphosphate approximately 500%.	Inositol triphosphate	66-87	coagulation factor II, thrombin	Homo sapiens	32-40
33096823-12	2020	The increase in [cAMP]i activates protein kinase A (PKA), followed by activation of the Src-epidermal growth factor receptor-Pphospholipase C (Src-EGFR-PLC) cascade, resulting in inositol-triphosphate (IP3) production, which mobilizes Ca2+ from the acrosome, causing a further increase in [Ca2+]i and the development of hyper-activated motility.	Inositol triphosphate	179-200	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	88-91
2992504-1	1985	A 2-min addition of LHRH to [3H]inositol-prelabeled rat granulosa cells in primary culture evoked significant increases in the accumulation of [3H]inositol phosphates, i.e. radiolabeled inositol monophosphate (IP), inositol diphosphate (IP2), and inositol triphosphate (IP3) levels increased to 210, 590 and 520%, respectively, when compared to control cultures.	Inositol triphosphate	247-268	gonadotropin releasing hormone 1	Rattus norvegicus	20-24
6296123-6	1983	Thrombin addition led to rapid increase in radioactivity in inositol triphosphate, but not in inositol diphosphate.	Inositol triphosphate	60-81	coagulation factor II, thrombin	Homo sapiens	0-8
34048227-4	2021	By applying inositol triphosphate (IP3) to samples during the unroofing process, we measured a much larger koff of 1.54 +- 0.42 s-1 for PLCdelta1-PH-GFP, indicating that rebinding events are significantly suppressed through competitive action by IP3 for the same PH domain binding site as phosphatidylinositol 4,5-bisphosphate (PIP2).	Inositol triphosphate	12-33	phospholipase C delta 1	Homo sapiens	136-145
3487991-1	1986	Previous studies indicated that thrombin-stimulation of platelets prelabeled with [3H]inositol or [32P]orthophosphate results in an increase of radioactive inositol triphosphate, a substance thought to modulate the levels of free intracellular calcium.	Inositol triphosphate	156-177	coagulation factor II, thrombin	Homo sapiens	32-40
3487991-5	1986	Using this protocol, the concentration of inositol triphosphate in resting and thrombin-stimulated platelets were determined to be 1-4 and 10-30 pmol/10(8) cells, respectively.	Inositol triphosphate	42-63	coagulation factor II, thrombin	Homo sapiens	79-87
34054821-8	2021	It has been known for a long time that FcgammaRIIa induces production of inositol triphosphate (IP3) to release calcium from intracellular stores, while FcgammaRIIIb does not use this phospholipid.	Inositol triphosphate	73-94	Fc gamma receptor IIa	Homo sapiens	39-50
29846015-4	2018	Our data showed that ectopic expression of AKR1B10 in breast cancer cells MCF-7 promoted lipogenesis and enhanced levels of lipid second messengers, including phosphatidylinositol bisphosphate (PIP2), diacylglycerol (DAG), and inositol triphosphate (IP3).	Inositol triphosphate	227-248	aldo-keto reductase family 1, member B10 (aldose reductase)	Mus musculus	43-50
30354813-8	2018	Klotho protein bound to AT1R (Ang II type-1 receptor) and decreased the presence of AT1R on HK-2 (human proximal tubular) cells, attenuating inositol triphosphate generation.	Inositol triphosphate	141-162	klotho	Homo sapiens	0-6
32457413-0	2020	Connexin43 and connexin50 channels exhibit different permeability to the second messenger inositol triphosphate.	Inositol triphosphate	90-111	gap junction protein alpha 1	Homo sapiens	0-10
32457413-0	2020	Connexin43 and connexin50 channels exhibit different permeability to the second messenger inositol triphosphate.	Inositol triphosphate	90-111	gap junction protein alpha 8	Homo sapiens	15-25
31301074-8	2020	Furthermore, the phospholipase C (PLC) inhibitor U73122 and the inositol triphosphate (IP 3 ) receptor inhibitor 2-aminoethoxydiphenyl borate inhibited the Ca 2+ signals.	Inositol triphosphate	64-85	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	87-102
31481523-7	2019	Alterations in the XCL1 amino terminus changed XCR1 activation, as determined by assessing inositol triphosphate accumulation, intracellular calcium release, and directed cell migration.	Inositol triphosphate	91-112	X-C motif chemokine ligand 1	Homo sapiens	19-23
30133494-6	2018	We investigate how Abeta affects individual flux contributions through inositol triphosphate (IP3) receptors, ryanodine receptors, and membrane pores.	Inositol triphosphate	71-92	amyloid beta precursor protein	Homo sapiens	19-24
28639721-4	2017	We have previously shown that inositol triphosphate-gated calcium release from internal stores is a major component of PID-related astroglial calcium signals, but whether external calcium influx through membrane-localized channels also contributes to PIDs has remained unclear.	Inositol triphosphate	30-51	preimplantation development	Mus musculus	119-122
30114340-8	2018	We show the CCL20 N-terminus tolerates truncation of up to 3 residues, extension by up to 5 additional residues, and point mutations at 4 of 5 positions with minimal loss of binding affinity and minimal impairment in ability to stimulate calcium mobilization, inositol triphosphate accumulation, chemotaxis, and beta-arrestin-2 recruitment.	Inositol triphosphate	260-281	C-C motif chemokine ligand 20	Homo sapiens	12-17
29780159-2	2018	Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE).	Inositol triphosphate	69-90	stromal interaction molecule 1	Homo sapiens	196-226
29780159-2	2018	Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE).	Inositol triphosphate	69-90	stromal interaction molecule 1	Homo sapiens	228-233
29780159-2	2018	Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE).	Inositol triphosphate	69-90	ORAI calcium release-activated calcium modulator 1	Homo sapiens	329-334
27717596-6	2016	MYO is the precursor of inositol triphosphate, a second messenger that regulates thyroid-stimulating hormone (TSH) and FSH as well as insulin.	Inositol triphosphate	24-45	insulin	Homo sapiens	134-141
29805993-10	2017	Conclusion: These data suggest that neural- and endothelial- inhibitory effects in autoantibodies from older adult diabetes with nephropathy and obesity/inflammation-associated complications are mediated by agonist autoantibodies directed against the 5-hydroxytryptamine 2 receptor positively coupled to the phospholipase C/inositol triphosphate/ cytosolic Ca2+ release pathway.	Inositol triphosphate	324-345	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	251-281
28404545-2	2017	Stimulation of the collagen receptor glycoprotein VI (GPVI) leads to phospholipase Cgamma2-dependent inositol triphosphate (IP3) production with subsequent platelet activation, due to increased intracellular Ca2+ concentration ([Ca2+]i).	Inositol triphosphate	101-122	glycoprotein VI platelet	Homo sapiens	54-58
28118027-4	2017	Gelsolin also binds to phosphatidylinositol 4,5-bisphosphate, making this substrate less available for phospholipase Cbeta-mediated hydrolysis to inositol triphosphate and diacylglycerol.	Inositol triphosphate	146-167	gelsolin	Mus musculus	0-8
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	epidermal growth factor	Homo sapiens	14-17
27566567-9	2016	However, [3-NT7]CXCL12 showed a reduced ability to enhance intracellular calcium concentrations, to generate inositol triphosphate, to phosphorylate ERK1/2 and to induce monocyte and lymphocyte chemotaxis in vitro.	Inositol triphosphate	109-130	C-X-C motif chemokine ligand 12	Homo sapiens	16-22
26328537-10	2016	PGE2, PGF2alpha, and TXA2 can contribute to the neurodegeneration via EP1, FP, and TP receptors, respectively, which are coupled with Gq, stimulate phospholipase C and cleave phosphatidylinositol diphosphate to produce inositol triphosphate and diacylglycerol.	Inositol triphosphate	219-240	prostaglandin E receptor 1	Homo sapiens	70-73
26416544-8	2016	The IMPA1 gene product is responsible for the final step of biotransformation of inositol triphosphate and diacylglycerol, two second messengers.	Inositol triphosphate	81-102	inositol monophosphatase 1	Homo sapiens	4-9
27198194-7	2016	Acute administration of BAC stimulated HCO3 (-) secretion in both cell lines and the NHE activity in CP-D cells by an inositol triphosphate-dependent calcium release.	Inositol triphosphate	118-139	solute carrier family 9 member C1	Homo sapiens	85-88
27018448-3	2016	Phospholipase S (PLC) is an enzyme playing an important role in platelet calcium signaling and responsible for release of inositol triphosphate (IP3) into platelet cytoplasm thus controlling intracellular calcium concentration.	Inositol triphosphate	122-143	heparan sulfate proteoglycan 2	Homo sapiens	17-20
26421996-5	2016	Activation of PLCgamma followed EGFR activation, resulting in Ca(2+) release from the endoplasmic reticulum (ER) via inositol triphosphate and ryanodine receptors.	Inositol triphosphate	117-138	epidermal growth factor receptor	Mus musculus	32-36
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	epidermal growth factor receptor	Homo sapiens	26-30
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	143-155
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	157-161
26551735-3	2016	Within 2 min, EGF elicits EGFR dependent activation of phospholipase C gamma (PLCgamma), producing inositol triphosphate (IP3), which binds to IP3 receptor (IP3R), opening the endoplasmic reticulum IP3R Ca(2+) channels, resulting in increased intracellular Ca(2+).	Inositol triphosphate	99-120	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	198-202
26269634-4	2015	Using a combination of whole-cell patch-clamp recording and biochemical analyses in hippocampal slices from young adult rats, we show that E2 acutely suppresses inhibition in females through mGluR1 stimulation of phospholipase C, leading to inositol triphosphate (IP3) generation, activation of the IP3 receptor (IP3R), and postsynaptic endocannabinoid release, likely of anandamide.	Inositol triphosphate	241-262	glutamate metabotropic receptor 1	Rattus norvegicus	191-197
26129938-9	2015	The GLP-1 secreting effect of GS is mediated by the G protein betagamma-subunit and inositol triphosphate.	Inositol triphosphate	84-105	glucagon	Mus musculus	4-9
25550457-2	2015	One of the key players in the regulation of inositol lipid signaling is the phospholipase Cbeta1 (PI-PLCbeta1), that hydrolyzes phosphatidylinositol 4,5-bisphosphate [PtIns(4,5)P2], giving rise to the second messengers inositol triphosphate and diacylglicerol.	Inositol triphosphate	219-240	phospholipase C, beta 1	Mus musculus	101-109
20436376-10	2010	The ability of Losartan to inhibit AngII-induced inositol triphosphate production also confirmed a loss in efficacy.	Inositol triphosphate	49-70	angiotensinogen	Homo sapiens	35-40
26664886-3	2015	There are several downstream pathways of Galphaq of which the best known is upon activation via guanosine triphosphate (GTP), Galphaq activates phospholipase Cbeta, hydrolyzing phosphatidylinositol 4,5-biphosphate into diacylglycerol and inositol triphosphate and activating protein kinase C and increasing calcium efflux from the endoplasmic reticulum.	Inositol triphosphate	238-259	G protein subunit alpha q	Rattus norvegicus	41-48
26664886-3	2015	There are several downstream pathways of Galphaq of which the best known is upon activation via guanosine triphosphate (GTP), Galphaq activates phospholipase Cbeta, hydrolyzing phosphatidylinositol 4,5-biphosphate into diacylglycerol and inositol triphosphate and activating protein kinase C and increasing calcium efflux from the endoplasmic reticulum.	Inositol triphosphate	238-259	G protein subunit alpha q	Rattus norvegicus	126-133
23856562-1	2014	Phosphoinositide-specific phospholipase C (PI-PLC) cleaves, in a Ca(2+)-dependent manner, phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) into diacylglycerol (DAG) and inositol triphosphate (IP3).	Inositol triphosphate	170-191	phospholipase C beta 1	Homo sapiens	0-41
23856562-1	2014	Phosphoinositide-specific phospholipase C (PI-PLC) cleaves, in a Ca(2+)-dependent manner, phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2) into diacylglycerol (DAG) and inositol triphosphate (IP3).	Inositol triphosphate	170-191	phospholipase C beta 1	Homo sapiens	43-49
24140715-5	2013	To identify the potential Galpha-subunit recruited by GnRH-(1-5) binding GPR173, we measured the second messengers cAMP and inositol triphosphate levels.	Inositol triphosphate	124-145	gonadotropin releasing hormone 1	Homo sapiens	54-63
24140715-5	2013	To identify the potential Galpha-subunit recruited by GnRH-(1-5) binding GPR173, we measured the second messengers cAMP and inositol triphosphate levels.	Inositol triphosphate	124-145	G protein-coupled receptor 173	Homo sapiens	73-79
21692826-3	2011	In 2010, we first identified its functional expression in Buffalo rat liver (BRL) cells and demonstrated that the activation of CaSR was involved in an increased intracellular calcium through the Gq subunit-phospholipase C-inositol triphosphate pathway.	Inositol triphosphate	223-244	calcium-sensing receptor	Rattus norvegicus	128-132
20682585-5	2011	The LPS-induced increase in CALC-I gene mRNA was partially blocked with verapamil, an L-type calcium channel blocker and blocked almost completely with 2-aminoethoxydiphenyl borate, a blocker of store-operated calcium entry and inositol triphosphate-mediated calcium release.	Inositol triphosphate	228-249	calcitonin related polypeptide alpha	Homo sapiens	28-32
21158935-6	2011	alpha-MSH-mediated calcium mobilization originated from intracellular calcium stores and was mediated by inositol triphosphate.	Inositol triphosphate	105-126	proopiomelanocortin	Homo sapiens	0-9
25010620-3	2014	Myo-inositol is the precursor of inositol triphosphate, a second messenger regulating many hormones such as TSH, FSH and insulin.	Inositol triphosphate	33-54	insulin	Homo sapiens	121-128
24753179-5	2014	We found that the ES-induced BDNF release required calcium influx through T-type voltage-gated calcium channel (VGCC) and calcium mobilization from internal calcium stores, including inositol triphosphate-sensitive stores and caffeine/ryanodine-sensitive stores.	Inositol triphosphate	183-204	brain derived neurotrophic factor	Homo sapiens	29-33
24062249-4	2014	Both AG (100 nmol/L) and dAG (100 nmol/L) significantly increased inositol triphosphate formation in human embryonic kidney-293 cells transfected with human GHSR.	Inositol triphosphate	66-87	growth hormone secretagogue receptor	Homo sapiens	157-161
22409987-7	2012	A CRACM-like current was detected following FcepsilonRI-dependent HLMC activation and also in HLMCs dialyzed with 30 muM inositol triphosphate.	Inositol triphosphate	121-142	Fc epsilon receptor Ia	Homo sapiens	44-55
23213416-0	2012	HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway.	Inositol triphosphate	67-88	BHLH domain-containing protein	Caenorhabditis elegans	0-6
21810651-6	2011	Investigation into potential mechanisms by which Nox1 modulates [Ca(2+)](i) showed that thrombin-induced inositol triphosphate generation and thapsigargin-induced intracellular calcium mobilization were similar in wild-type and Nox1 null SMCs.	Inositol triphosphate	105-126	coagulation factor II	Mus musculus	88-96
20859543-1	2010	The urotensin II receptor, bound by the ligand urotensin II, generates second messengers, ie, inositol triphosphate and diacylglycerol, which stimulate the subsequent release of calcium (Ca(2+)) in vascular smooth muscle cells.	Inositol triphosphate	94-115	urotensin 2	Homo sapiens	4-16
20859543-1	2010	The urotensin II receptor, bound by the ligand urotensin II, generates second messengers, ie, inositol triphosphate and diacylglycerol, which stimulate the subsequent release of calcium (Ca(2+)) in vascular smooth muscle cells.	Inositol triphosphate	94-115	urotensin 2	Homo sapiens	47-59
19823864-6	2010	hBest1 is, therefore, important for Ca(2+) handling of the ER store and may resemble the long-suspected counterion channel to balance transient membrane potentials occurring through inositol triphosphate (IP(3))-induced Ca(2+) release and store refill.	Inositol triphosphate	182-203	bestrophin 1	Homo sapiens	0-6
20377791-5	2010	As in other cellular systems, proteases such as thrombin and trypsin activate PAR-1 and PAR-2 on neurons of the dorsal motor nucleus of the vagus (DMV), leading to an increase in intracellular calcium levels via signal transduction mechanisms involving activation of phospholipase C and inositol triphosphate (IP3).	Inositol triphosphate	287-308	coagulation factor II, thrombin	Homo sapiens	48-56
20377791-5	2010	As in other cellular systems, proteases such as thrombin and trypsin activate PAR-1 and PAR-2 on neurons of the dorsal motor nucleus of the vagus (DMV), leading to an increase in intracellular calcium levels via signal transduction mechanisms involving activation of phospholipase C and inositol triphosphate (IP3).	Inositol triphosphate	287-308	coagulation factor II thrombin receptor	Homo sapiens	78-83
20377791-5	2010	As in other cellular systems, proteases such as thrombin and trypsin activate PAR-1 and PAR-2 on neurons of the dorsal motor nucleus of the vagus (DMV), leading to an increase in intracellular calcium levels via signal transduction mechanisms involving activation of phospholipase C and inositol triphosphate (IP3).	Inositol triphosphate	287-308	F2R like trypsin receptor 1	Homo sapiens	88-93
20030631-2	2010	The CaR stimulation elicits phospholipase C-mediated inositol triphosphate formation, leading to an elevation in the level of intracellular calcium released from endoplasmic reticulum (ER).	Inositol triphosphate	53-74	calcium-sensing receptor	Rattus norvegicus	4-7
19607714-8	2009	However, we observed that HMIT can transport inositol triphosphate, indicating unanticipated intracellular functions for this transporter that may be relevant to mood control.	Inositol triphosphate	45-66	solute carrier family 2 member 13	Rattus norvegicus	26-30
19752241-2	2009	We tested the hypothesis that activation of CB1 receptors inhibits N-methyl-d-aspartic acid (NMDA)-mediated calcium influx and cell death via the inositol triphosphate (IP(3)) signaling pathway in both primary dorsal root ganglia neurons and a cultured neuronal cell line (F-11 cells).	Inositol triphosphate	146-167	cannabinoid receptor 1	Homo sapiens	44-47
19460393-5	2009	We further show that CD-1 male mouse saliva and submaxillary gland extract induced significantly more attacks and a lower latency to attack in lactating female CD-1 mice and produced significantly more inositol triphosphate (IP(3)), indicative of phospholipase C(beta) signaling which mediates pheromonal activity, in CD-1 female VNO compared to PBS.	Inositol triphosphate	202-223	CD1 antigen complex	Mus musculus	21-25
19896516-7	2010	Pretreatment with urotensin receptor antagonist and inhibitor for phospholipase C (PLC), phosphoinositide 3-kinase (PI3K), or protein kinase C (PKC) attenuated hU-II-induced ANP secretion from atria paced with high frequency, but an inhibitor for inositol triphosphate did not.	Inositol triphosphate	247-268	urotensin 2	Homo sapiens	160-165
19224531-8	2009	The GluR5-mediated Ca(2+) increase was mediated by both canonical (ie, ionotropic) and noncanonical (metabotropic) signaling, dependent on a pertussis toxin-sensitive G protein/phospholipase C-dependent pathway, promoting Ca(2+) release from inositol triphosphate-dependent stores.	Inositol triphosphate	242-263	glutamate ionotropic receptor kainate type subunit 1	Rattus norvegicus	4-9
19461874-3	2009	Sequencing of genes contained in the interval revealed a homozygous mutation, S100P, in carbonic anhydrase related protein 8 (CA8), which is highly expressed in cerebellar Purkinje cells and influences inositol triphosphate (ITP) binding to its receptor ITPR1 on the endoplasmatic reticulum and thereby modulates calcium signaling.	Inositol triphosphate	202-223	S100 calcium binding protein P	Homo sapiens	78-83
19461874-3	2009	Sequencing of genes contained in the interval revealed a homozygous mutation, S100P, in carbonic anhydrase related protein 8 (CA8), which is highly expressed in cerebellar Purkinje cells and influences inositol triphosphate (ITP) binding to its receptor ITPR1 on the endoplasmatic reticulum and thereby modulates calcium signaling.	Inositol triphosphate	202-223	carbonic anhydrase 8	Homo sapiens	88-124
19461874-3	2009	Sequencing of genes contained in the interval revealed a homozygous mutation, S100P, in carbonic anhydrase related protein 8 (CA8), which is highly expressed in cerebellar Purkinje cells and influences inositol triphosphate (ITP) binding to its receptor ITPR1 on the endoplasmatic reticulum and thereby modulates calcium signaling.	Inositol triphosphate	202-223	carbonic anhydrase 8	Homo sapiens	126-129
19088423-6	2008	Confirming PLC activation, inositol triphosphate (IP3) production was increased by neomycin/gentamycin (p<0.05) and reduced by U73122.	Inositol triphosphate	27-48	heparan sulfate proteoglycan 2	Homo sapiens	11-14
18820027-5	2008	In addition, ET-1-stimulated inositol triphosphate formation was also significantly higher in VSMCs exposed to high glucose, whereas the basal levels of inositol triphosphate were not different between the two groups.	Inositol triphosphate	29-50	endothelin 1	Rattus norvegicus	13-17
18820027-5	2008	In addition, ET-1-stimulated inositol triphosphate formation was also significantly higher in VSMCs exposed to high glucose, whereas the basal levels of inositol triphosphate were not different between the two groups.	Inositol triphosphate	153-174	endothelin 1	Rattus norvegicus	13-17
18705646-4	2008	Upon activation, the MT1 receptor specifically couples to the G(alphai2), G(alphai3), G(alphaq), and G(alphall) proteins, and via activation of G(alphai2) proteins, melatonin suppresses forskolin-induced 3",5"-cyclic adenosine monophosphate production, while melatonin activation of G(alphaq), is able to inhibit phospholipid hydrolysis and ATP"s induction of inositol triphosphate production in MCF-7 breast cancer cells.	Inositol triphosphate	360-381	metallothionein 1I, pseudogene	Homo sapiens	21-24
18234900-11	2008	Further pharmacological analyses suggested that this form of LTP at FS-GABA neurons is induced through an activation of mGluR5, which triggers Ca2+ release from internal stores via activations of phospholipase C and inositol triphosphate.	Inositol triphosphate	216-237	glutamate receptor, ionotropic, kainate 1	Mus musculus	120-126
17549394-7	2007	IGF-I raised cyclic-AMP and inositol triphosphate release from dispersed guinea-pig cells, and the effect was reversed by the adenylate cyclase inhibitor SQ-22536 and the phospholipase-C (PLC) inhibitor U-73122.	Inositol triphosphate	28-49	insulin-like growth factor I	Cavia porcellus	0-5
17699673-0	2007	Inositol triphosphate-mediated Ca2+ signals direct purinergic P2Y receptor regulation of neuronal ion channels.	Inositol triphosphate	0-21	purinergic receptor P2Y1	Rattus norvegicus	62-65
17615981-3	2007	PAF binds surface special receptors inducing the formation of inositol triphosphate (IP3) and diacylglycerol (DAG) and increasing intracellular calcium.	Inositol triphosphate	62-83	PCNA clamp associated factor	Homo sapiens	0-3
17400813-4	2007	The CRFR1 was functional as evidenced by CRF stimulation of cAMP and inositol triphosphate production as well as by ligand induction of transcriptional activity of inducible cis-elements cAMP responsive element (CRE), activator protein 1 responsive element (AP-1) and POMC promoter) in ARPE-19 using luciferase reporter assay.	Inositol triphosphate	69-90	corticotropin releasing hormone receptor 1	Homo sapiens	4-9
17148667-8	2006	Resistin induced a rapid increase in intracellular calcium concentration, mainly through calcium release from intracellular inositol triphosphate-sensitive pools.	Inositol triphosphate	124-145	resistin	Homo sapiens	0-8
16601118-6	2006	Even more surprising, heteromeric Cx26/Cx32 channels showed striking differences in permeability among inositol phosphates with three or four phosphate groups and among isomers of inositol triphosphate.	Inositol triphosphate	180-201	gap junction protein beta 2	Homo sapiens	34-38
16996040-6	2006	This receptor increases inositol triphosphate production in transfected cells in presence of QRFP(26) and its mRNA was particularly enriched in ventral and posterior thalamic groups, anterior hypothalamus and medulla.	Inositol triphosphate	24-45	pyroglutamylated RFamide peptide	Rattus norvegicus	93-97
16720310-6	2006	The phenotypic effects of CRH in human skin cells are largely mediated by CRH-R1alpha through increases in concentrations of cAMP, inositol triphosphate (IP3), or Ca2+ with subsequent activation of protein kinases A (PKA) and C (PKC) dependent pathways.	Inositol triphosphate	131-152	corticotropin releasing hormone	Homo sapiens	26-29
16720310-6	2006	The phenotypic effects of CRH in human skin cells are largely mediated by CRH-R1alpha through increases in concentrations of cAMP, inositol triphosphate (IP3), or Ca2+ with subsequent activation of protein kinases A (PKA) and C (PKC) dependent pathways.	Inositol triphosphate	131-152	corticotropin releasing hormone	Homo sapiens	74-77
16305822-20	2006	Here we show that stimulation of Grm1 by l-quisqualate, a group I metabotropic glutamate receptor agonist, results in inositol triphosphate (IP3) accumulation, and the activation of ERK1/2 in these cell lines.	Inositol triphosphate	118-139	glutamate receptor, metabotropic 1	Mus musculus	33-37
16601118-6	2006	Even more surprising, heteromeric Cx26/Cx32 channels showed striking differences in permeability among inositol phosphates with three or four phosphate groups and among isomers of inositol triphosphate.	Inositol triphosphate	180-201	gap junction protein beta 1	Homo sapiens	39-43