PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29391504-6	2018	Furthermore, the hAOC3 inhibitors semicarbazide and imidazole reduce the binding of wild type and Arg/Ala mutated Siglec-9 peptides to hAOC3.	carbamylhydrazine	34-47	amine oxidase copper containing 3	Homo sapiens	17-22
29391504-6	2018	Furthermore, the hAOC3 inhibitors semicarbazide and imidazole reduce the binding of wild type and Arg/Ala mutated Siglec-9 peptides to hAOC3.	carbamylhydrazine	34-47	sialic acid binding Ig like lectin 9	Homo sapiens	114-122
29391504-6	2018	Furthermore, the hAOC3 inhibitors semicarbazide and imidazole reduce the binding of wild type and Arg/Ala mutated Siglec-9 peptides to hAOC3.	carbamylhydrazine	34-47	amine oxidase copper containing 3	Homo sapiens	135-140
21673127-8	2011	The presence of the aldehyde intermediate was verified by the formation of semicarbazide conjugates in human liver microsomal, S9, and recombinant CYP3A4 incubations of AMG657417.	carbamylhydrazine	75-88	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	147-153
29085929-4	2017	To demonstrate potential applications of this fluorogenic reaction, we synthesized a semicarbazide-presenting amino acid d-Dap-Scz, which readily incorporates into the cell wall of Staphalococcus aureus and serves as a handle for conjugation with the coumarins.	carbamylhydrazine	85-98	death associated protein	Homo sapiens	123-126
29085929-5	2017	The fluorogenic conjugation of the coumarins to cell surface semicarbazide enables facile visualization of d-Dap-Scz treated bacteria.	carbamylhydrazine	61-74	death associated protein	Homo sapiens	109-112
28228728-8	2017	Inhibiting SSAO with semicarbazide (1 mM) decreased amine oxidase activity in the MPVAT and AF.	carbamylhydrazine	21-34	amine oxidase, copper containing 3	Rattus norvegicus	11-15
26583521-0	2016	Tri-color emission and colorimetric recognition of acetate using semicarbazide and thio-semicarbazide derivatives: Experimental and computational studies.	carbamylhydrazine	65-78	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
24929547-3	2014	However, a remarkable anti-estrogenic effect of semicarbazide was demonstrated: semicarbazide treatment of female zebrafish for 96 h and 28 days resulted in significant decreases in transcript levels of vtg-1, ERalpha, and ERbeta, as well as decreases in the gonadosomatic index level after 28 days.	carbamylhydrazine	48-61	vitellogenin 1	Danio rerio	203-208
24929547-3	2014	However, a remarkable anti-estrogenic effect of semicarbazide was demonstrated: semicarbazide treatment of female zebrafish for 96 h and 28 days resulted in significant decreases in transcript levels of vtg-1, ERalpha, and ERbeta, as well as decreases in the gonadosomatic index level after 28 days.	carbamylhydrazine	48-61	estrogen receptor 1	Danio rerio	210-217
24929547-3	2014	However, a remarkable anti-estrogenic effect of semicarbazide was demonstrated: semicarbazide treatment of female zebrafish for 96 h and 28 days resulted in significant decreases in transcript levels of vtg-1, ERalpha, and ERbeta, as well as decreases in the gonadosomatic index level after 28 days.	carbamylhydrazine	80-93	vitellogenin 1	Danio rerio	203-208
24929547-3	2014	However, a remarkable anti-estrogenic effect of semicarbazide was demonstrated: semicarbazide treatment of female zebrafish for 96 h and 28 days resulted in significant decreases in transcript levels of vtg-1, ERalpha, and ERbeta, as well as decreases in the gonadosomatic index level after 28 days.	carbamylhydrazine	80-93	estrogen receptor 1	Danio rerio	210-217
24929547-4	2014	Moreover, semicarbazide exposure significantly inhibited the induction of vtg-1, ERalpha and ERbeta mRNA by E2 when male zebrafish were co-exposed for 28 days.	carbamylhydrazine	10-23	vitellogenin 1	Danio rerio	74-79
24929547-4	2014	Moreover, semicarbazide exposure significantly inhibited the induction of vtg-1, ERalpha and ERbeta mRNA by E2 when male zebrafish were co-exposed for 28 days.	carbamylhydrazine	10-23	estrogen receptor 1	Danio rerio	81-88
22714978-1	2012	Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) is involved in vascular endothelial damage as well as in the vascular degeneration underlying diabetes mellitus and Alzheimer"s disease (AD).	carbamylhydrazine	0-13	amine oxidase copper containing 3	Homo sapiens	67-71
22714978-1	2012	Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) is involved in vascular endothelial damage as well as in the vascular degeneration underlying diabetes mellitus and Alzheimer"s disease (AD).	carbamylhydrazine	0-13	amine oxidase copper containing 3	Homo sapiens	72-77
22364027-4	2011	Animals received FA (10 mg/kg); or methylamine - substrate of FA-generating enzyme SSAO, (250 mg/kg); or semicarbazide - SSAO inhibitor, (200 mg/kg).	carbamylhydrazine	105-118	amine oxidase, copper containing 3	Rattus norvegicus	121-125
27043821-1	2016	Given that the elevated serum semicarbazide-sensitive amine oxidase (SSAO) activity is associated with the severity of carotid atherosclerosis in clinic, the current study aims to investigate whether SSAO inactivation by semicarbazide is beneficial for established atherosclerotic lesions in LDLr knockout mice on a high-fat/high- cholesterol Western-type diet or after dietary lipid lowering.	carbamylhydrazine	30-43	amine oxidase, copper containing 3	Mus musculus	69-73
27043821-1	2016	Given that the elevated serum semicarbazide-sensitive amine oxidase (SSAO) activity is associated with the severity of carotid atherosclerosis in clinic, the current study aims to investigate whether SSAO inactivation by semicarbazide is beneficial for established atherosclerotic lesions in LDLr knockout mice on a high-fat/high- cholesterol Western-type diet or after dietary lipid lowering.	carbamylhydrazine	30-43	amine oxidase, copper containing 3	Mus musculus	200-204
25572340-9	2015	By contrast, benzylamine oxidation was only abolished by semicarbazide: hence SSAO-mediated.	carbamylhydrazine	57-70	amine oxidase copper containing 3	Homo sapiens	78-82
21321060-8	2011	Two CYP2C9-specific semicarbazide adducts of losartan (S1 and S2) were detected.	carbamylhydrazine	20-33	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	4-10
21166805-7	2011	The Fal-stimulated GSH loss from viable astrocytes was completely prevented by semicarbazide-mediated chemical removal of Fal or by the application of MK571, an inhibitor of the multidrug resistance protein 1.	carbamylhydrazine	79-92	ATP binding cassette subfamily B member 1	Homo sapiens	178-208
20877383-2	2011	Vascular adhesion protein-1 (VAP-1), a semicarbazide (SCZ)-sensitive-amine-oxidase, was found in previous studies to have a role in migration of immune cells.	carbamylhydrazine	39-52	amine oxidase, copper containing 3	Mus musculus	0-27
20877383-2	2011	Vascular adhesion protein-1 (VAP-1), a semicarbazide (SCZ)-sensitive-amine-oxidase, was found in previous studies to have a role in migration of immune cells.	carbamylhydrazine	39-52	amine oxidase, copper containing 3	Mus musculus	29-34
20877383-2	2011	Vascular adhesion protein-1 (VAP-1), a semicarbazide (SCZ)-sensitive-amine-oxidase, was found in previous studies to have a role in migration of immune cells.	carbamylhydrazine	54-57	amine oxidase, copper containing 3	Mus musculus	0-27
20877383-2	2011	Vascular adhesion protein-1 (VAP-1), a semicarbazide (SCZ)-sensitive-amine-oxidase, was found in previous studies to have a role in migration of immune cells.	carbamylhydrazine	54-57	amine oxidase, copper containing 3	Mus musculus	29-34
21146547-10	2011	Administration of SCZ, HYD, or LJP 1207 reduced the myocardial infarct size and decreased leukocyte infiltration and endothelial P-selectin expression in myocardial I/R injury in vivo.	carbamylhydrazine	18-21	selectin P	Rattus norvegicus	129-139
19789505-6	2009	MAO activity with 50 microM [14C]PEA was partially inhibited by clorgyline, and total inhibition was achieved only by the combination of clorgyline and semicarbazide, suggesting the presence of SSAO.	carbamylhydrazine	152-165	amine oxidase copper containing 2	Homo sapiens	194-198
21331292-0	2011	Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue.	carbamylhydrazine	23-36	WD and tetratricopeptide repeats 1	Mus musculus	140-147
21331292-3	2011	Here, we studied whether oral administration of semicarbazide, a prototypical SSAO inhibitor, limits fat deposition in mice.	carbamylhydrazine	48-61	amine oxidase, copper containing 3	Mus musculus	78-82
21331292-7	2011	Consequently, the insulin-like action of the SSAO substrate benzylamine on glucose transport was abolished in adipocytes from semicarbazide-drinking mice, while their insulin sensitivity was not altered.	carbamylhydrazine	126-139	amine oxidase, copper containing 3	Mus musculus	45-49
21428797-2	2010	RESULTS: In murine adipocytes, benzylamine mimics another insulin action: it enhances apelin expression in a manner that is blocked by the semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) inhibitor semicarbazide.	carbamylhydrazine	139-152	insulin	Homo sapiens	58-65
21428797-2	2010	RESULTS: In murine adipocytes, benzylamine mimics another insulin action: it enhances apelin expression in a manner that is blocked by the semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) inhibitor semicarbazide.	carbamylhydrazine	139-152	apelin	Mus musculus	86-92
21428797-2	2010	RESULTS: In murine adipocytes, benzylamine mimics another insulin action: it enhances apelin expression in a manner that is blocked by the semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) inhibitor semicarbazide.	carbamylhydrazine	139-152	amine oxidase, copper containing 3	Mus musculus	206-210
21428797-2	2010	RESULTS: In murine adipocytes, benzylamine mimics another insulin action: it enhances apelin expression in a manner that is blocked by the semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) inhibitor semicarbazide.	carbamylhydrazine	139-152	amine oxidase, copper containing 3	Mus musculus	211-216
21428797-2	2010	RESULTS: In murine adipocytes, benzylamine mimics another insulin action: it enhances apelin expression in a manner that is blocked by the semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) inhibitor semicarbazide.	carbamylhydrazine	228-241	apelin	Mus musculus	86-92
21428797-2	2010	RESULTS: In murine adipocytes, benzylamine mimics another insulin action: it enhances apelin expression in a manner that is blocked by the semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) inhibitor semicarbazide.	carbamylhydrazine	228-241	amine oxidase, copper containing 3	Mus musculus	206-210
20337582-5	2010	Nearly all potent and selective Cat C inhibitors described are based on the preferred dipeptide substrates bearing either irreversible (e.g. diazomethylketone, acyloxymethyl ketone, o-acyl hydroxamic acid and vinyl sulfone) or reversible (e.g. semicarbazide, nitrile and cyanamide) electrophilic warheads.	carbamylhydrazine	244-257	cathepsin C	Mus musculus	32-37
20538694-8	2010	In the rat model, we confirmed that use of the inhibitor semicarbazide prevented adverse effects caused by delayed tPA administration, leading to a smaller infarct volume.	carbamylhydrazine	57-70	plasminogen activator, tissue type	Rattus norvegicus	115-118
20799605-2	2010	The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide.	carbamylhydrazine	397-410	monoamine oxidase A	Rattus norvegicus	4-7
20799605-2	2010	The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide.	carbamylhydrazine	397-410	monoamine oxidase A	Rattus norvegicus	106-109
20799605-2	2010	The MAOs from both studied biological sources show catalytic properties resembling those of the classical MAO of terrestrial vertebrates: they deaminate tyramine, tryptamine, serotonin, benzylamine and do not deaminate histamine, have sensitivity to chlorgiline, the specific inhibitor of the MAO A form, and deprenyl, the specific inhibitor of the MAO B form, and are not inhibited with 10(-2) M semicarbazide.	carbamylhydrazine	397-410	monoamine oxidase A	Rattus norvegicus	106-109
19524603-1	2009	To investigate a putative role for semicarbazide-sensitive amine oxidase (SSAO) in arterial extracellular matrix (ECM) organization, we compared arteries of growing Brown Norway (BN) rats after chronic administration of semicarbazide (SCZ) and beta-aminopropionitrile (BAPN), two inhibitors with different properties and relative specificities for SSAO and lysyl oxidase (LOX).	carbamylhydrazine	35-48	amine oxidase, copper containing 3	Rattus norvegicus	74-78
19524603-5	2009	Both compounds similarly inhibited LOX, whereas SCZ inhibited SSAO far more effectively than BAPN.	carbamylhydrazine	48-51	amine oxidase, copper containing 3	Rattus norvegicus	62-66
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	carbamylhydrazine	255-268	monoamine oxidase A	Rattus norvegicus	29-32
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	carbamylhydrazine	255-268	monoamine oxidase A	Rattus norvegicus	47-50
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	carbamylhydrazine	255-268	monoamine oxidase A	Rattus norvegicus	47-50
16859404-3	2006	Monoamine oxidase (MAO) and an intracellular form of polyamine oxidase (PAO) contain flavin adenine dinucleotide (FAD) as their cofactor, whereas a second group of amine oxidases without FAD contain a cofactor possessing one or more carbonyl groups, making them sensitive to inhibition by carbonyl reagents such as semicarbazide; this group includes semicarbazide-sensitive amine oxidase (SSAO) and the connective tissue enzyme, lysyl oxidase.	carbamylhydrazine	315-328	polyamine oxidase	Homo sapiens	53-70
17872591-10	2007	Semicarbazide, a nonspecific SPL inhibitor, reduced SPL activity in vitro by approximately 70% using both standard and fluorescence methods.	carbamylhydrazine	0-13	sphingosine-1-phosphate lyase 1	Homo sapiens	29-32
17872591-10	2007	Semicarbazide, a nonspecific SPL inhibitor, reduced SPL activity in vitro by approximately 70% using both standard and fluorescence methods.	carbamylhydrazine	0-13	sphingosine-1-phosphate lyase 1	Homo sapiens	52-55
17900567-3	2007	The present paper examines the Fos-protein distribution in the brain of rats submitted to a conditioned place aversion (CPA) paradigm using the dPAG chemical stimulation with semicarbazide (SMC), an inhibitor of the GABA synthesizing enzyme, as US and the quadrant of an arena where the drug was injected as the paired neutral stimulus.	carbamylhydrazine	175-188	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
17900567-3	2007	The present paper examines the Fos-protein distribution in the brain of rats submitted to a conditioned place aversion (CPA) paradigm using the dPAG chemical stimulation with semicarbazide (SMC), an inhibitor of the GABA synthesizing enzyme, as US and the quadrant of an arena where the drug was injected as the paired neutral stimulus.	carbamylhydrazine	190-193	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
17900567-4	2007	Our results show that CPA associated with SMC injections caused a significant Fos labeling in the laterodorsal nucleus of the thalamus (LD), basolateral nucleus of amygdala (BLA) and in the dorsomedial PAG (dmPAG).	carbamylhydrazine	42-45	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-81
17452500-3	2007	The aim of the present study was to examine the effect of semicarbazide (SCZ), an efficient SSAO inhibitor, on the arterial phenotype of the carotid artery in relation to modulation of SSAO and lysyl oxidase activities in growing rats.	carbamylhydrazine	58-71	amine oxidase, copper containing 3	Rattus norvegicus	92-96
17452500-3	2007	The aim of the present study was to examine the effect of semicarbazide (SCZ), an efficient SSAO inhibitor, on the arterial phenotype of the carotid artery in relation to modulation of SSAO and lysyl oxidase activities in growing rats.	carbamylhydrazine	58-71	amine oxidase, copper containing 3	Rattus norvegicus	185-189
17452500-3	2007	The aim of the present study was to examine the effect of semicarbazide (SCZ), an efficient SSAO inhibitor, on the arterial phenotype of the carotid artery in relation to modulation of SSAO and lysyl oxidase activities in growing rats.	carbamylhydrazine	73-76	amine oxidase, copper containing 3	Rattus norvegicus	92-96
17452500-3	2007	The aim of the present study was to examine the effect of semicarbazide (SCZ), an efficient SSAO inhibitor, on the arterial phenotype of the carotid artery in relation to modulation of SSAO and lysyl oxidase activities in growing rats.	carbamylhydrazine	73-76	amine oxidase, copper containing 3	Rattus norvegicus	185-189
17452500-4	2007	We first show that after 6 weeks of SCZ treatment (100 mg/kg per day), SSAO activity was reduced by 90%, whereas lysyl oxidase activity was only partially inhibited (<60%) in carotid artery, compared with controls.	carbamylhydrazine	36-39	amine oxidase, copper containing 3	Rattus norvegicus	71-75
17452500-7	2007	In addition, extracellular proteins other than insoluble elastin and collagen were increased in SCZ-treated rats.	carbamylhydrazine	96-99	elastin	Rattus norvegicus	57-64
17452500-11	2007	Because these abnormalities are essentially absent in SSAO-deficient mice, our results suggest that lysyl oxidase inhibition is responsible for the major part of the vascular phenotype of SCZ-treated rats.	carbamylhydrazine	188-191	amine oxidase, copper containing 3	Mus musculus	54-58
16979412-6	2006	In addition, tyramine and benzylamine impaired tumor necrosis factor alpha-dependent nitric oxide formation in a pargyline- and semicarbazide-sensitive manner, respectively.	carbamylhydrazine	128-141	tumor necrosis factor	Mus musculus	47-74
18044709-1	2008	BACKGROUND: Using a recent model of dissecting aortic aneurysm (DAA) caused by in utero exposure to semicarbazide, we examined the elastin and collagen using standard methods and two nonlinear imaging techniques, multiphoton fluorescence (MPF) and second harmonic generation (SHG) microscopy.	carbamylhydrazine	100-113	elastin	Rattus norvegicus	131-138
17386734-5	2007	The decision limit CCalpha expressed for the underivatised metabolite is 0.05 microg kg(-1) for 3-amino-5-methyl-morpholino-2-oxazolidinone, 0.03 microg kg(-1) for 3-amino-2-oxazolidinone, 0.20 microg kg(-1) for semicarbazide and 0.22 microg kg(-1) for 1-amino-hydantoin.	carbamylhydrazine	212-225	fibrillin 2	Homo sapiens	19-26
17256751-3	2007	We report that in addition to supporting leukocyte adhesion, provision of specific substrate to VAP-1 results in hepatic endothelial cell activation, which can be abrogated by treatment with the enzyme inhibitor semicarbazide.	carbamylhydrazine	212-225	amine oxidase copper containing 3	Homo sapiens	96-101
17385065-3	2007	Since these novel pyrazoline derivatives have been found to act as suicide inhibitors of SSAO, the semicarbazide group in these molecules may be responsible for the SSAO inhibitory action.	carbamylhydrazine	99-112	amine oxidase, copper containing 3	Rattus norvegicus	89-93
17385065-3	2007	Since these novel pyrazoline derivatives have been found to act as suicide inhibitors of SSAO, the semicarbazide group in these molecules may be responsible for the SSAO inhibitory action.	carbamylhydrazine	99-112	amine oxidase, copper containing 3	Rattus norvegicus	165-169
17095030-6	2006	Allylamine-induced hypercontraction and blood vessel SSAO activity were abolished by pretreatment with semicarbazide or MDL 72274-E but not by MDL 72274-Z.	carbamylhydrazine	103-116	amine oxidase copper containing 2	Homo sapiens	53-57
16569443-6	2006	The results obtained showed that freezing behavior induced by semicarbazide was associated with an increase in Fos expression in the dorsomedial column of the PAG (dmPAG) only, while bicuculline-induced escape was related to widespread increase in Fos labeling, notably in the periaqueductal gray, hypothalamus nuclei, amygdaloid nuclei, the laterodorsal nucleus of thalamus (LD), the cuneiform nucleus (CnF) and the locus coeruleus (LC).	carbamylhydrazine	62-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-114
16507542-6	2006	In a series of second experiments, we illustrate a developmental model of dissecting aortic aneurysm (DAA) obtained by administering semicarbazide, an inhibitor of the little-studied VSMC enzyme semicarbazide-sensitive amine oxidase (SSAO), to pregnant rats during the last trimester of development.	carbamylhydrazine	133-146	amine oxidase, copper containing 3	Rattus norvegicus	195-232
16397885-1	2006	BACKGROUND: A chemical-induced, nonlethal, dissecting aortic aneurysm (DAA) is described following in utero exposure to semicarbazide, an inhibitor of the vascular enzyme semicarbazide sensitive amine oxidase (SSAO).	carbamylhydrazine	120-133	amine oxidase, copper containing 3	Rattus norvegicus	171-208
16397885-1	2006	BACKGROUND: A chemical-induced, nonlethal, dissecting aortic aneurysm (DAA) is described following in utero exposure to semicarbazide, an inhibitor of the vascular enzyme semicarbazide sensitive amine oxidase (SSAO).	carbamylhydrazine	120-133	amine oxidase, copper containing 3	Rattus norvegicus	210-214
16507542-6	2006	In a series of second experiments, we illustrate a developmental model of dissecting aortic aneurysm (DAA) obtained by administering semicarbazide, an inhibitor of the little-studied VSMC enzyme semicarbazide-sensitive amine oxidase (SSAO), to pregnant rats during the last trimester of development.	carbamylhydrazine	133-146	amine oxidase, copper containing 3	Rattus norvegicus	234-238
16116337-4	2005	Parallel experiments were run with semicarbazide, the prototypical hydrazine SSAO inhibitor.	carbamylhydrazine	35-48	amine oxidase, copper containing 3	Rattus norvegicus	77-81
15075350-4	2004	Pargyline and semicarbazide, specific inhibitors of MAO and SSAO, respectively, canceled this negative effect of MAO substrates on NOS2 expression.	carbamylhydrazine	14-27	monoamine oxidase A	Rattus norvegicus	52-55
15996642-4	2005	To investigate this issue further, reduction of GABA transmission was performed with local injections of either the GABA-A receptor antagonist bicuculline or the glutamic acid decarboxylase (GAD) inhibitor semicarbazide into the dorsolateral periaqueductal gray (dlPAG).	carbamylhydrazine	206-219	glutamate decarboxylase 1	Homo sapiens	162-189
15996642-4	2005	To investigate this issue further, reduction of GABA transmission was performed with local injections of either the GABA-A receptor antagonist bicuculline or the glutamic acid decarboxylase (GAD) inhibitor semicarbazide into the dorsolateral periaqueductal gray (dlPAG).	carbamylhydrazine	206-219	glutamate decarboxylase 1	Homo sapiens	191-194
15893930-0	2005	Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI).	carbamylhydrazine	6-19	cathepsin C	Homo sapiens	48-70
15893930-0	2005	Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI).	carbamylhydrazine	6-19	cathepsin C	Homo sapiens	72-77
15893930-2	2005	Using 1 as a starting point (IC50>10 microM), we have improved potency by more than 500-fold and successfully identified novel inhibitors of DPPI via screening of a one-bead-two-compounds library of semicarbazide derivatives.	carbamylhydrazine	202-215	cathepsin C	Homo sapiens	144-148
15075350-4	2004	Pargyline and semicarbazide, specific inhibitors of MAO and SSAO, respectively, canceled this negative effect of MAO substrates on NOS2 expression.	carbamylhydrazine	14-27	amine oxidase, copper containing 3	Rattus norvegicus	60-64
15075350-4	2004	Pargyline and semicarbazide, specific inhibitors of MAO and SSAO, respectively, canceled this negative effect of MAO substrates on NOS2 expression.	carbamylhydrazine	14-27	monoamine oxidase A	Rattus norvegicus	113-116
15075350-4	2004	Pargyline and semicarbazide, specific inhibitors of MAO and SSAO, respectively, canceled this negative effect of MAO substrates on NOS2 expression.	carbamylhydrazine	14-27	nitric oxide synthase 2	Rattus norvegicus	131-135
15027872-5	2004	Characterization of tyramine oxidase, carried out prior to the inhibition experiments, confirmed earlier suggestions that this enzyme is a semicarbazide-sensitive copper-containing monoamine oxidase.	carbamylhydrazine	139-152	monoamine oxidase B	Homo sapiens	20-36
14978192-9	2004	These effects were blocked by previous treatments with semicarbazide, a SSAO inhibitor.	carbamylhydrazine	55-68	amine oxidase, copper containing 3	Mus musculus	72-76
14643318-5	2003	In this series, semicarbazide 8b and bromoacetamides 18b,c were found to be potent HDAC inhibitors for non-hydroxamates.	carbamylhydrazine	16-29	histone deacetylase 9	Homo sapiens	83-87
14697907-1	2004	Semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6) is a group of enzymes highly sensitive to inhibition by semicarbazide.	carbamylhydrazine	113-126	amine oxidase copper containing 2	Homo sapiens	0-37
14697907-1	2004	Semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6) is a group of enzymes highly sensitive to inhibition by semicarbazide.	carbamylhydrazine	113-126	amine oxidase copper containing 2	Homo sapiens	39-43
14715500-5	2004	Semicarbazide significantly blocked MA-induced relaxation (%inhibition: 82.5 +/- 4.8, n = 7) and SSAO activity (%inhibition: 98.1 +/- 1.3, n = 26) in LIMA.	carbamylhydrazine	0-13	amine oxidase copper containing 2	Homo sapiens	97-101
12860041-3	2003	A reverse phase HPLC method with pre-column derivatisation using semicarbazide for the simultaneous measurement of PLP, its degradation product, 4-pyridoxic acid (PA) and pyridoxal (PL) in plasma and red cells was developed.	carbamylhydrazine	65-78	pyridoxal phosphatase	Homo sapiens	115-118
12951068-3	2003	Computer-assisted morphometry of the ischaemic reperfused hearts stained with nitroblue tetrazolium showed the extension of damaged myocardium (area at risk and infarct size) significantly reduced in rats treated with histaminase, in comparison with the non-treated rats, whereas no protection was found with the semicarbazide inactivated histaminase.	carbamylhydrazine	313-326	amine oxidase, copper containing 1	Rattus norvegicus	218-229
12431050-5	2002	A unique combination of active pharmacophores led us to a series of semicarbazide-based inhibitors that are highly potent against CDK2 and CDK4 while maintaining selectivity against other relevant serine/threonine kinases.	carbamylhydrazine	68-81	cyclin dependent kinase 2	Homo sapiens	130-134
12431050-5	2002	A unique combination of active pharmacophores led us to a series of semicarbazide-based inhibitors that are highly potent against CDK2 and CDK4 while maintaining selectivity against other relevant serine/threonine kinases.	carbamylhydrazine	68-81	cyclin dependent kinase 4	Homo sapiens	139-143
12359232-4	2002	The SSAO activity was completely inhibited by 10 mM semicarbazide.	carbamylhydrazine	52-65	amine oxidase, copper containing 3	Rattus norvegicus	4-8
11958526-9	2002	Semicarbazide, a SSAO inhibitor, enhances the formation of .OH products of efflux/oxidation due to 1-methyl-4-phenylpyridinium ion (MPP+).	carbamylhydrazine	0-13	amine oxidase, copper containing 3	Rattus norvegicus	17-21
11950211-7	2002	The l-lysine generated from N(epsilon)-(gamma-l-glutamyl)-l-lysine in an endpoint assay is converted to alpha-keto epsilon-aminocaproate semicarbazone in the presence of semicarbazide, excess l-lysine alpha-oxidase, and catalase.	carbamylhydrazine	170-183	catalase	Rattus norvegicus	194-228
12213997-7	2001	In some cultures, SSAO was selectively inhibited with semicarbazide or MDL-72145 [(E)-2-(3,4-dimethoxyphenyl)-3-fluoroallylamine].	carbamylhydrazine	54-67	amine oxidase, copper containing 3	Rattus norvegicus	18-22
11522672-6	2001	The improvement caused by benzylamine plus vanadate was abolished when rats were pretreated with the SSAO-inhibitor semicarbazide.	carbamylhydrazine	116-129	amine oxidase, copper containing 3	Rattus norvegicus	101-105
11543647-6	2001	Pretreatment with the SSAO inhibitor semicarbazide (1 mM; 10 min) prevented or significantly reduced the majority of AA"s effects in both CA and TA rings and inhibited 100% of the SSAO activity present in rat TA and human CA and TA.	carbamylhydrazine	37-50	amine oxidase, copper containing 3	Rattus norvegicus	22-26
11543647-6	2001	Pretreatment with the SSAO inhibitor semicarbazide (1 mM; 10 min) prevented or significantly reduced the majority of AA"s effects in both CA and TA rings and inhibited 100% of the SSAO activity present in rat TA and human CA and TA.	carbamylhydrazine	37-50	amine oxidase, copper containing 3	Rattus norvegicus	180-184
11389684-6	2001	This effect was insensitive to pargyline (an MAO inhibitor), but was inhibited by semicarbazide (an SSAO inhibitor) and by N-acetylcysteine (an antioxidant agent), suggesting the involvement of the H(2)O(2) generated during SSAO-dependent amine oxidation.	carbamylhydrazine	82-95	amine oxidase, copper containing 3	Mus musculus	100-104
11389684-6	2001	This effect was insensitive to pargyline (an MAO inhibitor), but was inhibited by semicarbazide (an SSAO inhibitor) and by N-acetylcysteine (an antioxidant agent), suggesting the involvement of the H(2)O(2) generated during SSAO-dependent amine oxidation.	carbamylhydrazine	82-95	amine oxidase, copper containing 3	Mus musculus	224-228
11788466-7	2002	This methylamine effect was reproduced by other SSAO substrates and was prevented by the SSAO inhibitor semicarbazide.	carbamylhydrazine	104-117	amine oxidase, copper containing 3	Rattus norvegicus	89-93
11513731-6	2001	This effect could be related to SSAO activation, since it was antagonized in the presence of the SSAO inhibitor semicarbazide, but not in the presence of the monoamine oxidase inhibitor pargyline.	carbamylhydrazine	112-125	amine oxidase, copper containing 3	Mus musculus	32-36
11513731-6	2001	This effect could be related to SSAO activation, since it was antagonized in the presence of the SSAO inhibitor semicarbazide, but not in the presence of the monoamine oxidase inhibitor pargyline.	carbamylhydrazine	112-125	amine oxidase, copper containing 3	Mus musculus	97-101
11302941-5	2001	This result was confirmed in vitro in rat and human plasma by the use of semicarbazide, a specific SSAO inhibitor.	carbamylhydrazine	73-86	amine oxidase copper containing 2	Homo sapiens	99-103
11303044-7	2001	In isolated adipocytes, SSAO oxidized similarly benzylamine and methylamine that dose dependently stimulated glucose transport in a semicarbazide-sensitive manner.	carbamylhydrazine	132-145	amine oxidase copper containing 2	Homo sapiens	24-28
11008875-4	2000	The enzyme with lower affinity for benzylamine was identified as spermine oxidase, the oxidation of [14C]-benzylamine was inhibited by semicarbazide, alpha-aminoguanidine and B24, a specific inhibitor of benzylamine oxidase and spermine oxidase, both SSAO enzymes.	carbamylhydrazine	135-148	spermine oxidase	Cavia porcellus	65-81
11061216-6	2000	The IC50 values of semicarbazide were estimated to be 5x10(-3) M and 5x10(-4) M for SSAO from human serum and saphenous vein, respectively.	carbamylhydrazine	19-32	amine oxidase copper containing 2	Homo sapiens	84-88
11008875-4	2000	The enzyme with lower affinity for benzylamine was identified as spermine oxidase, the oxidation of [14C]-benzylamine was inhibited by semicarbazide, alpha-aminoguanidine and B24, a specific inhibitor of benzylamine oxidase and spermine oxidase, both SSAO enzymes.	carbamylhydrazine	135-148	spermine oxidase	Cavia porcellus	228-244
10328770-11	1999	Deamination of aminoacetone was nearly completely inhibited by 1 mM semicarbazide and 1 microM MDL-72974A, a potent selective SSAO inhibitor, whereas MAO inhibitors clorgyline (1 mM) and deprenyl (1 mM) had no inhibitory effect.	carbamylhydrazine	68-81	amine oxidase copper containing 2	Homo sapiens	126-130
10406932-9	1999	Consistent with the role of SSAO in biotransformation of AA, the SSAO inhibitor semicarbazide (SC; 100 microM) provided nearly complete protection from AA to both VSMC-AA and VSMC.	carbamylhydrazine	80-93	amine oxidase copper containing 2	Homo sapiens	65-69
20654405-6	1998	Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively.	carbamylhydrazine	29-42	polyamine oxidase	Rattus norvegicus	101-104
10079209-7	1999	However, the amount of mature elastin was lowered and mature collagen was raised in the aortas of animals treated chronically with semicarbazide.	carbamylhydrazine	131-144	elastin	Homo sapiens	30-37
9892192-5	1999	Adding 5 mM semicarbazide to incubations increased the observed depentylation (except that due to CYP2E1) by >60%.	carbamylhydrazine	12-25	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	98-104
10591046-7	1999	The presence of 1-2 mM semicarbazide, necessary for determining MAO activities in samples also containing SSAO, did not adversely affect the derivatization reaction.	carbamylhydrazine	23-36	monoamine oxidase A	Rattus norvegicus	64-67
20654405-6	1998	Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively.	carbamylhydrazine	29-42	polyamine oxidase	Rattus norvegicus	82-99
20654405-6	1998	Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively.	carbamylhydrazine	29-42	amine oxidase, copper containing 3	Rattus norvegicus	110-147
20654405-6	1998	Aminoguanidine, MDL72,527 or semicarbazide, are the inhibitors of amine oxidases, polyamine oxidase (PAO) and semicarbazide-sensitive amine oxidase (SSAO), respectively.	carbamylhydrazine	29-42	amine oxidase, copper containing 3	Rattus norvegicus	149-153
9536030-5	1998	A similar effect of MAO and SSAO inhibitors was obtained in both the intact cells and the membranes: half of the activity was sensitive to semicarbazide and the other half more easily inhibited by MAO-A than by MAO-B inhibitors.	carbamylhydrazine	139-152	monoamine oxidase A	Rattus norvegicus	20-23
9525902-8	1998	This synergistic effect of benzylamine and vanadate on glucose transport was totally abolished in the presence of semicarbazide, a specific inhibitor of SSAO.	carbamylhydrazine	114-127	amine oxidase, copper containing 3	Rattus norvegicus	153-157
9536030-5	1998	A similar effect of MAO and SSAO inhibitors was obtained in both the intact cells and the membranes: half of the activity was sensitive to semicarbazide and the other half more easily inhibited by MAO-A than by MAO-B inhibitors.	carbamylhydrazine	139-152	amine oxidase, copper containing 3	Rattus norvegicus	28-32
1483111-6	1992	Porcine SSAO was inhibited both by semicarbazide and phenelzine while deprenyl or clorgyline were without any effect on enzyme activity.	carbamylhydrazine	35-48	amine oxidase copper containing 2	Homo sapiens	8-12
9503571-5	1997	The cytotoxic actions of 50 microM AA were not altered by coincubation with 100 microM pargyline (an inhibitor of monoamine oxidase, MAO) but were completely prevented by 100 microM semicarbazide (SSAO inhibitor) and propargylamine (MAO/SSAO inhibitor).	carbamylhydrazine	182-195	amine oxidase copper containing 2	Homo sapiens	197-201
9503571-5	1997	The cytotoxic actions of 50 microM AA were not altered by coincubation with 100 microM pargyline (an inhibitor of monoamine oxidase, MAO) but were completely prevented by 100 microM semicarbazide (SSAO inhibitor) and propargylamine (MAO/SSAO inhibitor).	carbamylhydrazine	182-195	amine oxidase copper containing 2	Homo sapiens	237-241
8363633-2	1993	Oxidation of MA was completely inhibited by 0.1-1 mM semicarbazide, without being affected by the monoamine oxidase (MAO) inhibitor, pargyline (1 mM), indicating that MA is metabolized by semicarbazide-sensitive amine oxidase (SSAO) and not by MAO.	carbamylhydrazine	53-66	amine oxidase, copper containing 3	Rattus norvegicus	188-225
8430435-2	1993	Previous studies showed that allylamine-induced chronic lesions are markedly reduced by semicarbazide, an inhibitor of semicarbazide-sensitive amine oxidase (SSAO), and that allylamine is metabolized to the aldehyde, acrolein, by SSAO.	carbamylhydrazine	88-101	amine oxidase, copper containing 3	Rattus norvegicus	119-156
8430435-2	1993	Previous studies showed that allylamine-induced chronic lesions are markedly reduced by semicarbazide, an inhibitor of semicarbazide-sensitive amine oxidase (SSAO), and that allylamine is metabolized to the aldehyde, acrolein, by SSAO.	carbamylhydrazine	88-101	amine oxidase, copper containing 3	Rattus norvegicus	158-162
8430435-2	1993	Previous studies showed that allylamine-induced chronic lesions are markedly reduced by semicarbazide, an inhibitor of semicarbazide-sensitive amine oxidase (SSAO), and that allylamine is metabolized to the aldehyde, acrolein, by SSAO.	carbamylhydrazine	88-101	amine oxidase, copper containing 3	Rattus norvegicus	230-234
1976780-2	1990	MA metabolism was found to be inhibited almost completely by 1 mM semicarbazide, but virtually unaffected by 0.1 mM clorgyline, suggesting that MA is a substrate for the semicarbazide-sensitive amino oxidase (SSAO) activities which also metabolize benzylamine (BZ) in these sources.	carbamylhydrazine	66-79	amine oxidase copper containing 2	Homo sapiens	170-207
2043677-2	1991	Incubation of BMAA with L-AAO in the presence of semicarbazide led to the formation of a semicarbazone, indicating intermediate iminium ion formation; when potassium cyanide (5 mM) was added, semicarbazone formation was blocked.	carbamylhydrazine	49-62	interleukin 4 induced 1	Homo sapiens	24-29
2376607-2	1990	Pyridoxal-5"-phosphate (PLP) bound to proteins as a Schiff base was liberated and stabilized by reaction with semicarbazide.	carbamylhydrazine	110-123	pyridoxal phosphatase	Homo sapiens	24-27
1637818-4	1992	The stereochemical course of the bovine and porcine aortic semicarbazide-sensitive amine oxidase reaction was investigated using chiral tyramines, deuterated at C-1 and C-2, and 1H-NMR spectroscopy to establish the loss or retention of deuterium in product p-hydroxyphenethyl alcohols.	carbamylhydrazine	59-72	complement C2	Bos taurus	161-172
1631902-3	1992	Inhibitor studies using the specific SSAO inhibitor semicarbazide and the monoamine oxidase inhibitor pargyline indicate that SSAO is responsible for metabolism of methylamine to formaldehyde.	carbamylhydrazine	52-65	amine oxidase, copper containing 3	Rattus norvegicus	37-41
1631902-3	1992	Inhibitor studies using the specific SSAO inhibitor semicarbazide and the monoamine oxidase inhibitor pargyline indicate that SSAO is responsible for metabolism of methylamine to formaldehyde.	carbamylhydrazine	52-65	amine oxidase, copper containing 3	Rattus norvegicus	126-130
1976780-2	1990	MA metabolism was found to be inhibited almost completely by 1 mM semicarbazide, but virtually unaffected by 0.1 mM clorgyline, suggesting that MA is a substrate for the semicarbazide-sensitive amino oxidase (SSAO) activities which also metabolize benzylamine (BZ) in these sources.	carbamylhydrazine	66-79	amine oxidase copper containing 2	Homo sapiens	209-213
3421992-6	1988	The inhibition curves with clorgyline, deprenyl, semicarbazide and KCN, measuring the remaining activity towards 1 microM of benzylamine, indicated that in mitochondria 5% of the total activity is due to the presence of SSAO activity whereas in microsomes this activity represents about 20%.	carbamylhydrazine	49-62	amine oxidase, copper containing 3	Rattus norvegicus	220-224
2503040-3	1989	The absence of the semicarbazide-sensitive amine oxidase (SSAO) was confirmed by the lack of effect of semicarbazide on the benzylamine oxidation.	carbamylhydrazine	19-32	amine oxidase copper containing 2	Homo sapiens	58-62
2568436-2	1989	Administration of hydralazine (5 mg kg-1) or semicarbazide (100 mg kg-1), drugs which irreversibly inhibit semicarbazide-sensitive amine oxidases (SSAO) but not monoamine oxidase (MAO), enhanced MMA excretion by around three- to six-fold above pretreatment levels, whereas no effect of pargyline (25 mg kg-1), a selective irreversible inhibitor of MAO was found.	carbamylhydrazine	45-58	amine oxidase, copper containing 3	Rattus norvegicus	107-145
2568436-2	1989	Administration of hydralazine (5 mg kg-1) or semicarbazide (100 mg kg-1), drugs which irreversibly inhibit semicarbazide-sensitive amine oxidases (SSAO) but not monoamine oxidase (MAO), enhanced MMA excretion by around three- to six-fold above pretreatment levels, whereas no effect of pargyline (25 mg kg-1), a selective irreversible inhibitor of MAO was found.	carbamylhydrazine	45-58	amine oxidase, copper containing 3	Rattus norvegicus	147-151
2568436-2	1989	Administration of hydralazine (5 mg kg-1) or semicarbazide (100 mg kg-1), drugs which irreversibly inhibit semicarbazide-sensitive amine oxidases (SSAO) but not monoamine oxidase (MAO), enhanced MMA excretion by around three- to six-fold above pretreatment levels, whereas no effect of pargyline (25 mg kg-1), a selective irreversible inhibitor of MAO was found.	carbamylhydrazine	45-58	monoamine oxidase A	Rattus norvegicus	180-183
2568436-2	1989	Administration of hydralazine (5 mg kg-1) or semicarbazide (100 mg kg-1), drugs which irreversibly inhibit semicarbazide-sensitive amine oxidases (SSAO) but not monoamine oxidase (MAO), enhanced MMA excretion by around three- to six-fold above pretreatment levels, whereas no effect of pargyline (25 mg kg-1), a selective irreversible inhibitor of MAO was found.	carbamylhydrazine	45-58	monoamine oxidase A	Rattus norvegicus	348-351
6428190-5	1984	Semicarbazide and aminoguanidine are 10-respectively 1000-fold more potent inhibitors of the human intestinal diamine oxidase.	carbamylhydrazine	0-13	amine oxidase copper containing 1	Homo sapiens	110-125
3138700-8	1988	The fact that "original homogenate" and the subcellular fractions show some sensitivity to semicarbazide also indicates that a semicarbazide-sensitive amine oxidase (SSAO) is present in the C3H mouse kidney.	carbamylhydrazine	91-104	amine oxidase, copper containing 3	Mus musculus	127-164
3138700-8	1988	The fact that "original homogenate" and the subcellular fractions show some sensitivity to semicarbazide also indicates that a semicarbazide-sensitive amine oxidase (SSAO) is present in the C3H mouse kidney.	carbamylhydrazine	91-104	amine oxidase, copper containing 3	Mus musculus	166-170
2888772-7	1987	Lysyl oxidase inhibitors beta-aminopropionitrile, aminoacetonitrile, semicarbazide, and isonicotinic acid hydrazide were given to newborn chicks, to chick embryos, and to newborn rats, and the ultrastructural alterations of the aortic elastic fibers were analyzed and compared with the extent of the enzyme inhibition.	carbamylhydrazine	69-82	lysyl oxidase	Gallus gallus	0-13
2842890-3	1988	Semicarbazide (SC) and diethyldithiocarbamate (DDC) were used as inhibitors of semicarbazide-sensitive amine oxidase (SSAO).	carbamylhydrazine	0-13	amine oxidase, copper containing 3	Rattus norvegicus	79-116
2842890-3	1988	Semicarbazide (SC) and diethyldithiocarbamate (DDC) were used as inhibitors of semicarbazide-sensitive amine oxidase (SSAO).	carbamylhydrazine	0-13	amine oxidase, copper containing 3	Rattus norvegicus	118-122
2842890-3	1988	Semicarbazide (SC) and diethyldithiocarbamate (DDC) were used as inhibitors of semicarbazide-sensitive amine oxidase (SSAO).	carbamylhydrazine	15-17	amine oxidase, copper containing 3	Rattus norvegicus	118-122
3785548-3	1986	The GABA formation from ABAL was invariably observed in striatum in which GAD was severely inhibited by semicarbazide or kainic acid.	carbamylhydrazine	104-117	glutamate decarboxylase 1	Homo sapiens	74-77
2867184-6	1985	Staining was prevented by the SSAO inhibitors hydroxylamine (1 microM) and semicarbazide (1 mM), but not by the MAO inhibitor, clorgyline (1 mM).	carbamylhydrazine	75-88	amine oxidase, copper containing 3	Rattus norvegicus	30-34
6136581-2	1983	Clorgyline inhibition curves at 10 and 100 microM n-pentylamine indicated that this substrate was deaminated by MAO-A, -B and a clorgyline-resistant amine oxidase sensitive to inhibition by semicarbazide.	carbamylhydrazine	190-203	monoamine oxidase A	Rattus norvegicus	112-121
6983619-1	1982	This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates.	carbamylhydrazine	167-180	dopa decarboxylase	Rattus norvegicus	50-76
6983619-1	1982	This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates.	carbamylhydrazine	167-180	dopa decarboxylase	Rattus norvegicus	78-82
6189671-12	1983	Semicarbazide produced a significant decrease of these levels not only in the foetuses, offspring and pregnant rats but also in the controls, F2 and F3, from treated P and F1 respectively.	carbamylhydrazine	0-13	coagulation factor II	Rattus norvegicus	142-151
6983619-1	1982	This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates.	carbamylhydrazine	182-184	dopa decarboxylase	Rattus norvegicus	50-76
6787849-2	1981	Special attention has been paid to treatments that are known to affect the activity of diamine oxidase (DAO, histaminase, EC, 1.4.3.6), a copper-containing enzyme characteristically inhibited by semicarbazide.	carbamylhydrazine	195-208	amine oxidase, copper containing 1	Rattus norvegicus	87-102
6983619-1	1982	This paper describes the distribution of aromatic L-amino acid decarboxylase (AADC) activities in fourteen tissues (eight peripheral tissues and six brain regions) of semicarbazide (SC)-treated rats, using both L-DOPA and L-5-hydroxytryptophan (L-5-HTP) as substrates.	carbamylhydrazine	182-184	dopa decarboxylase	Rattus norvegicus	78-82
7054184-5	1982	Oxidative deamination of L-cysteine by L-amino acid oxidase yields the highly reactive imine, 2-imino-3-mercaptopropionic acid, which can be quantitatively trapped with semicarbazide.	carbamylhydrazine	169-182	interleukin 4 induced 1	Homo sapiens	39-59
7298626-4	1981	Of the various chemicals tested, only those which contained either a free amino group (except lysine) and/or a free sulfhydryl group (e.g. semicarbazide, cysteine, glycine, glucosamine) effectively blocked (40-80%) the binding of 14C as well as protected against acrolein-induced denaturation of cytochrome P-450.	carbamylhydrazine	139-152	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	296-312
6787849-2	1981	Special attention has been paid to treatments that are known to affect the activity of diamine oxidase (DAO, histaminase, EC, 1.4.3.6), a copper-containing enzyme characteristically inhibited by semicarbazide.	carbamylhydrazine	195-208	amine oxidase, copper containing 1	Rattus norvegicus	104-107
6787849-2	1981	Special attention has been paid to treatments that are known to affect the activity of diamine oxidase (DAO, histaminase, EC, 1.4.3.6), a copper-containing enzyme characteristically inhibited by semicarbazide.	carbamylhydrazine	195-208	amine oxidase, copper containing 1	Rattus norvegicus	109-120
7437422-4	1980	The effect of semicarbazide as an O3 scavenger is complicated by the fact that ozonolysis of semicarbazide yields a product that causes inhibition of glyceraldehyde-3-phosphate dehydrogenase.	carbamylhydrazine	14-27	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	150-190
7202411-2	1981	Carboxylase groups in bovine pancreatic phospholipase A2 were modified using a water-soluble carbodiimide and semicarbazide.	carbamylhydrazine	110-123	LOC104974671	Bos taurus	40-56
7437422-4	1980	The effect of semicarbazide as an O3 scavenger is complicated by the fact that ozonolysis of semicarbazide yields a product that causes inhibition of glyceraldehyde-3-phosphate dehydrogenase.	carbamylhydrazine	93-106	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	150-190
877399-4	1977	Experiments made with rat abdominal aorta and inferior vena cava disclosed clorgyline-sensitive and resistant MAO activity, the latter being inhibited by semicarbazide but not by deprenyl or pargyline.	carbamylhydrazine	154-167	monoamine oxidase A	Rattus norvegicus	110-113
6249439-9	1980	Depletion of GABA by semicarbazide blocked DRP-1, but had only a modest effect of DRP-2.	carbamylhydrazine	21-34	collapsin response mediator protein 1	Homo sapiens	43-48
6770612-4	1980	Aminoguanidine and semicarbazide inhibited the human intestinal enzyme like a classical diamine oxidase.	carbamylhydrazine	19-32	amine oxidase copper containing 1	Homo sapiens	88-103
7189580-1	1980	The influence of semicarbazide (SC), an inhibitor of glutamate decarboxylase (GDC), on electrical and respiratory activity of the Purkinje cells and cortical neurons of mice was investigated in tissue culture.	carbamylhydrazine	17-30	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	78-81
7189580-1	1980	The influence of semicarbazide (SC), an inhibitor of glutamate decarboxylase (GDC), on electrical and respiratory activity of the Purkinje cells and cortical neurons of mice was investigated in tissue culture.	carbamylhydrazine	32-34	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	78-81
4388687-20	1968	The dehydrogenase is inhibited by semicarbazide (K(i) 3.35mum), isoniazid (K(i) 1.17mum), cuprizone (K(i) 0.49mum), p-chloromercuribenzoate (K(i) 0.45mm) and quinacrine (K(i) 12.1mm).	carbamylhydrazine	34-47	MEXAM1_RS21720	Methylobacterium extorquens AM1	4-17
30650583-4	2019	Semicarbazide and other molecules inhibiting SSAO/VAP-1 also reduce adiposity in obese rodents.	carbamylhydrazine	0-13	amine oxidase, copper containing 3	Rattus norvegicus	45-49
33312420-7	2020	We then utilised hepatocytes in culture and human precision cut liver slices in concert with selective enzyme activity inhibitors to test the effects of activating the semicarbazide-sensitive amine oxidase activity of VAP-1 on hepatic lipid uptake and triglyceride export.	carbamylhydrazine	168-181	amine oxidase copper containing 3	Homo sapiens	218-223
33312420-16	2020	This suggests that targeting the semicarbazide sensitive amine oxidase capacity of VAP-1 may represent a useful adjunct to other therapeutic strategies in NAFLD.	carbamylhydrazine	33-46	amine oxidase copper containing 3	Homo sapiens	83-88
32961181-1	2020	We investigated whether the modification of the negatively charged carboxyl groups with semicarbazide could confer membrane-disrupting and cytotoxic properties to bovine alpha-lactalbumin (LA).	carbamylhydrazine	88-101	lactalbumin alpha	Bos taurus	170-187
32410850-5	2020	Human VAP-1 was more sensitive compared to rat or mouse VAP-1 (lowest IC50 concentration) to semicarbazide but was least sensitive to hydralazine and LJP-1207.	carbamylhydrazine	93-106	amine oxidase copper containing 3	Homo sapiens	6-11
32410850-5	2020	Human VAP-1 was more sensitive compared to rat or mouse VAP-1 (lowest IC50 concentration) to semicarbazide but was least sensitive to hydralazine and LJP-1207.	carbamylhydrazine	93-106	amine oxidase, copper containing 3	Mus musculus	56-61
30650583-4	2019	Semicarbazide and other molecules inhibiting SSAO/VAP-1 also reduce adiposity in obese rodents.	carbamylhydrazine	0-13	amine oxidase, copper containing 3	Rattus norvegicus	50-55
28428344-6	2018	The adhesion of gut-tropic alpha4beta7+lymphocytes to hepatic endothelial cells in vitro under flow was attenuated by 50% following administration of the VAP-1 inhibitor semicarbazide (p<0.01).	carbamylhydrazine	170-183	amine oxidase copper containing 3	Homo sapiens	154-159