PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33588685-2	2021	Phosgene"s high toxicity and physical properties resulted in its use as a chemical warfare agent during the First World War with a designation of CG ("Choky Gas").	Phosgene	0-8	cathepsin G	Homo sapiens	146-148
7891366-1	1994	The different production of phosgene and free-radicals from CHCl3 and CCl4 was determined in vitro and in vivo, by measuring the regioselective binding to the two intermediates to phospholipid (PL) molecules.	Phosgene	28-36	C-C motif chemokine ligand 4	Rattus norvegicus	70-74
34874153-1	2021	A bis-heteroleptic ruthenium(II) complex, Ru-1, of 4,7-bis(2-aminoethylamino)-1,10-phenanthroline for selective "turn-on" detection of highly toxic chemical warfare agent phosgene is presented.	Phosgene	171-179	Scm like with four mbt domains 1	Homo sapiens	42-46
34874153-4	2021	Probe Ru-1 showed a rapid and highly selective luminescence turn-on response for phosgene over other competitive chemical warfare agents with a low detection limit (13.9 nM) in CH3CN.	Phosgene	81-89	Scm like with four mbt domains 1	Homo sapiens	6-10
34874153-5	2021	The 2-aminoethylamino groups in Ru-1 act as a reacting site for nucleophilic addition to the carbonyl center of phosgene and undergo intramolecular cyclization.	Phosgene	112-120	Scm like with four mbt domains 1	Homo sapiens	32-36
34874153-7	2021	1H NMR titration of Ru-1 with phosgene supported the reaction mechanism and also pointed to the simultaneous reaction of phosgene at two 2-aminoethylamino sites.	Phosgene	30-38	Scm like with four mbt domains 1	Homo sapiens	20-24
34874153-7	2021	1H NMR titration of Ru-1 with phosgene supported the reaction mechanism and also pointed to the simultaneous reaction of phosgene at two 2-aminoethylamino sites.	Phosgene	121-129	Scm like with four mbt domains 1	Homo sapiens	20-24
34874153-10	2021	The cyclization reaction with phosgene and the corresponding 2-imidazolidinone product formation populated the emissive 3MLCT state in Ru-1-Phos and is the key reason for the enhanced luminescence.	Phosgene	30-38	Scm like with four mbt domains 1	Homo sapiens	135-139
34874153-11	2021	Furthermore, a low-cost portable test paper strip has been fabricated with Ru-1 for the real-time selective monitoring of phosgene gas at the nanomolar level.	Phosgene	122-130	Scm like with four mbt domains 1	Homo sapiens	75-79
35355403-0	2022	NEDD4 attenuates phosgene-induced acute lung injury through the inhibition of Notch1 activation.	Phosgene	17-25	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	0-5
35355403-0	2022	NEDD4 attenuates phosgene-induced acute lung injury through the inhibition of Notch1 activation.	Phosgene	17-25	notch receptor 1	Rattus norvegicus	78-84
35355403-6	2022	NEDD4 overexpression attenuated phosgene-induced lung inflammation, lowering the high lung injury score (based on total protein, inflammatory cells and inflammatory factors in bronchoalveolar lavage fluid) and also reduced phosgene-induced oxidative stress and cell apoptosis.	Phosgene	32-40	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	0-5
35355403-6	2022	NEDD4 overexpression attenuated phosgene-induced lung inflammation, lowering the high lung injury score (based on total protein, inflammatory cells and inflammatory factors in bronchoalveolar lavage fluid) and also reduced phosgene-induced oxidative stress and cell apoptosis.	Phosgene	223-231	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	0-5
35355403-8	2022	Therefore, we demonstrated that NEDD4 plays a protective role in alleviating phosgene-induced ALI, suggesting that enhancing the effect of NEDD4 may be a new approach for treating phosgene-induced ALI.	Phosgene	77-85	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	32-37
35355403-8	2022	Therefore, we demonstrated that NEDD4 plays a protective role in alleviating phosgene-induced ALI, suggesting that enhancing the effect of NEDD4 may be a new approach for treating phosgene-induced ALI.	Phosgene	77-85	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	139-144
35355403-8	2022	Therefore, we demonstrated that NEDD4 plays a protective role in alleviating phosgene-induced ALI, suggesting that enhancing the effect of NEDD4 may be a new approach for treating phosgene-induced ALI.	Phosgene	180-188	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	139-144
7057422-1	1982	Reaction of 5,6,7,8-tetrahydrofolic acid (THF,7) with phosgene, thiophosgene, and cyanogen bromide gave the bridged derivatives, 5,10-(CO)-THF (8), 5,10-(CS)-THF (9), and 5,10-(C = NH)-THF (11), respectively.	Phosgene	54-62	thin fur	Mus musculus	42-45
7057422-1	1982	Reaction of 5,6,7,8-tetrahydrofolic acid (THF,7) with phosgene, thiophosgene, and cyanogen bromide gave the bridged derivatives, 5,10-(CO)-THF (8), 5,10-(CS)-THF (9), and 5,10-(C = NH)-THF (11), respectively.	Phosgene	54-62	thin fur	Mus musculus	139-142
7057422-1	1982	Reaction of 5,6,7,8-tetrahydrofolic acid (THF,7) with phosgene, thiophosgene, and cyanogen bromide gave the bridged derivatives, 5,10-(CO)-THF (8), 5,10-(CS)-THF (9), and 5,10-(C = NH)-THF (11), respectively.	Phosgene	54-62	thin fur	Mus musculus	139-142
7057422-1	1982	Reaction of 5,6,7,8-tetrahydrofolic acid (THF,7) with phosgene, thiophosgene, and cyanogen bromide gave the bridged derivatives, 5,10-(CO)-THF (8), 5,10-(CS)-THF (9), and 5,10-(C = NH)-THF (11), respectively.	Phosgene	54-62	thin fur	Mus musculus	139-142
32394537-0	2020	Overexpression of heat shock protein 70 enhanced mesenchymal stem cell treatment efficacy in phosgene-induced acute lung injury.	Phosgene	93-101	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	18-39
33691364-0	2021	[Effects of over-expressing heat shock protein 60 on marrow mesenchymal stem cells in the treatment of phosgene-induced acute lung injury].	Phosgene	103-111	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	28-49
33691364-13	2021	Conclusion: MSCs transfected with HSP60 can enhance the ability of proliferation, anti apoptosis, migration and the curative effect in rats with phosgene induced acute lung injury.	Phosgene	145-153	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	34-39
32394537-3	2020	We aimed to assess that MSCs overexpressed Hsp70 could enhance the capacity of MSCs and have a good therapeutic effect on phosgene-induced ALI.	Phosgene	122-130	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	43-48
32394537-13	2020	MSCs overexpressed Hsp70 can enhance the capacity and efficacy of MSCs in the treatment of phosgene-induced ALI and may be mediated through the PI3k/AKT signaling pathway.	Phosgene	91-99	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	19-24
32394537-13	2020	MSCs overexpressed Hsp70 can enhance the capacity and efficacy of MSCs in the treatment of phosgene-induced ALI and may be mediated through the PI3k/AKT signaling pathway.	Phosgene	91-99	AKT serine/threonine kinase 1	Rattus norvegicus	149-152
32524298-0	2020	Adenine based molecular junction as biosensor for detection of toxic phosgene gas.	Phosgene	69-77	gastrin	Homo sapiens	78-81
32524298-6	2020	Also, the variation of HOMO-LUMO gap of adenine molecule on adsorption of phosgene leads to alteration of current and voltage, thus implying that adenine-based sensor can be effectively utilized to sense the presence of phosgene gas in a given environment.	Phosgene	220-228	gastrin	Homo sapiens	229-232
32524298-6	2020	Also, the variation of HOMO-LUMO gap of adenine molecule on adsorption of phosgene leads to alteration of current and voltage, thus implying that adenine-based sensor can be effectively utilized to sense the presence of phosgene gas in a given environment.	Phosgene	74-82	gastrin	Homo sapiens	229-232
32280908-0	2020	Adsorption of Phosgene Gas on Pristine and Copper-Decorated B12N12 Nanocages: A Comparative DFT Study.	Phosgene	14-22	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	23-26
33012731-0	2020	NLRP3 gene silencing ameliorates phosgene-induced acute lung injury in rats by inhibiting NLRP3 inflammasome and proinflammatory factors, but not anti-inflammatory factors.	Phosgene	33-41	NLR family, pyrin domain containing 3	Rattus norvegicus	0-5
31707339-0	2020	Lung-derived exosomes in phosgene-induced acute lung injury regulate the functions of mesenchymal stem cells partially via miR-28-5p.	Phosgene	25-33	microRNA 28	Homo sapiens	123-129
33012731-0	2020	NLRP3 gene silencing ameliorates phosgene-induced acute lung injury in rats by inhibiting NLRP3 inflammasome and proinflammatory factors, but not anti-inflammatory factors.	Phosgene	33-41	NLR family, pyrin domain containing 3	Rattus norvegicus	90-95
33012731-1	2020	NOD-like receptor protein 3 (NLRP3) is involved in acute lung injury (ALI), but its exact role in phosgene-induced ALI is not clearly understood.	Phosgene	98-106	NLR family, pyrin domain containing 3	Rattus norvegicus	0-27
33012731-1	2020	NOD-like receptor protein 3 (NLRP3) is involved in acute lung injury (ALI), but its exact role in phosgene-induced ALI is not clearly understood.	Phosgene	98-106	NLR family, pyrin domain containing 3	Rattus norvegicus	29-34
33012731-2	2020	The aim of the study is to explore the potential therapeutic effect of NLRP3 inflammasome modulation in the management of phosgene-induced ALI.	Phosgene	122-130	NLR family, pyrin domain containing 3	Rattus norvegicus	71-76
33012731-16	2020	Disruption of NLRP3 inflammasome activation might be used as a therapeutic modality for the treatment of phosgene-induced ALI.	Phosgene	105-113	NLR family, pyrin domain containing 3	Rattus norvegicus	14-19
30460964-1	2018	The reaction of bis(triphenylphosphine)iridium(i) carbonyl chloride (Vaska"s complex) with a series of 1-iodopolyynes (1-CnI and 2-CnI) gave sigma-polyynyl iridium(iii) complexes with general formula R(C[triple bond, length as m-dash]C)nIr(PPh3)2(Cl)(I)(CO).	Phosgene	48-67	5'-nucleotidase, cytosolic IA	Homo sapiens	121-124
30460964-1	2018	The reaction of bis(triphenylphosphine)iridium(i) carbonyl chloride (Vaska"s complex) with a series of 1-iodopolyynes (1-CnI and 2-CnI) gave sigma-polyynyl iridium(iii) complexes with general formula R(C[triple bond, length as m-dash]C)nIr(PPh3)2(Cl)(I)(CO).	Phosgene	48-67	5'-nucleotidase, cytosolic IA	Homo sapiens	131-134
31966482-0	2017	Melatonin attenuates phosgene-induced acute lung injury via the upregulation Wnt/beta-catenin pathway.	Phosgene	21-29	Wnt family member 2	Rattus norvegicus	77-80
31966482-0	2017	Melatonin attenuates phosgene-induced acute lung injury via the upregulation Wnt/beta-catenin pathway.	Phosgene	21-29	catenin beta 1	Rattus norvegicus	81-93
16839062-5	2005	In the reactions CH2Cl + NO2, CHCl2 + NO2, and CCl3 + NO2, the products observed are formaldehyde, CHClO, and phosgene (CCl2O), respectively.	Phosgene	110-118	C-C motif chemokine ligand 3	Homo sapiens	47-51
25511263-11	2014	The Western blot showed that the phosgene inhalation group had significantly increased expression of iNOS and p-p38 compared with the air control group (P < 0.01); the MT treatment and SB203580 groups had lower expression of iNOS and p-p38 than the phosgene inhalation group (P < 0.05).	Phosgene	33-41	nitric oxide synthase 2	Rattus norvegicus	101-105
25511263-11	2014	The Western blot showed that the phosgene inhalation group had significantly increased expression of iNOS and p-p38 compared with the air control group (P < 0.01); the MT treatment and SB203580 groups had lower expression of iNOS and p-p38 than the phosgene inhalation group (P < 0.05).	Phosgene	33-41	mitogen activated protein kinase 14	Rattus norvegicus	112-115
25511263-11	2014	The Western blot showed that the phosgene inhalation group had significantly increased expression of iNOS and p-p38 compared with the air control group (P < 0.01); the MT treatment and SB203580 groups had lower expression of iNOS and p-p38 than the phosgene inhalation group (P < 0.05).	Phosgene	33-41	nitric oxide synthase 2	Rattus norvegicus	228-232
25511263-11	2014	The Western blot showed that the phosgene inhalation group had significantly increased expression of iNOS and p-p38 compared with the air control group (P < 0.01); the MT treatment and SB203580 groups had lower expression of iNOS and p-p38 than the phosgene inhalation group (P < 0.05).	Phosgene	33-41	mitogen activated protein kinase 14	Rattus norvegicus	239-242