PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11384867-3	2001	In the last years, it was demonstrated that various progestins (promegestone, nomegestrol acetate, medrogestone), as well as tibolone and its metabolites are potent inhibitors of sulfatase and 17beta-hydroxysteroid dehydrogenase activities.	Medrogestone	99-111	arylsulfatase family member H	Homo sapiens	179-188
19962254-4	2009	As discussed in this review, various progestogens including dydrogesterone and its 20alpha-dihydro-derivative, medrogestone, promegestone, nomegestrol acetate and norelgestromin can reduce intratissular levels of estradiol in breast cancer by blocking sulfatase and 17beta-hydroxysteroid-dehydrogenase type 1 activities.	Medrogestone	111-123	arylsulfatase family member H	Homo sapiens	252-261
19962254-4	2009	As discussed in this review, various progestogens including dydrogesterone and its 20alpha-dihydro-derivative, medrogestone, promegestone, nomegestrol acetate and norelgestromin can reduce intratissular levels of estradiol in breast cancer by blocking sulfatase and 17beta-hydroxysteroid-dehydrogenase type 1 activities.	Medrogestone	111-123	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	266-308
19179024-4	2009	It was demonstrated that various progestins (e.g. nomegestrol acetate, medrogestone, promegestone), as well as tibolone and its metabolites, can block the enzymes involved in estradiol bioformation (sulfatase, 17beta-hydroxysteroid dehydrogenase) in breast cancer.	Medrogestone	71-83	arylsulfatase family member H	Homo sapiens	199-208
19179024-4	2009	It was demonstrated that various progestins (e.g. nomegestrol acetate, medrogestone, promegestone), as well as tibolone and its metabolites, can block the enzymes involved in estradiol bioformation (sulfatase, 17beta-hydroxysteroid dehydrogenase) in breast cancer.	Medrogestone	71-83	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	210-245
17943537-9	2007	It has been demonstrated that various progestins (e.g. nomegestrol acetate, medrogestone, promegestone) as well as tibolone and their metabolites can block the enzymes involved in E(2) bioformation (sulfatase, 17beta-hydroxysteroid dehydrogenase) in breast cancer cells.	Medrogestone	76-88	arylsulfatase family member H	Homo sapiens	199-208
17943537-9	2007	It has been demonstrated that various progestins (e.g. nomegestrol acetate, medrogestone, promegestone) as well as tibolone and their metabolites can block the enzymes involved in E(2) bioformation (sulfatase, 17beta-hydroxysteroid dehydrogenase) in breast cancer cells.	Medrogestone	76-88	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	210-245
12227886-4	2001	It has been demonstrated that, in hormone-dependent breast cancer cells, various progestins (nomegestrol acetate, medrogestone, promegestone) are potent sulfatase inhibitory agents.	Medrogestone	114-126	arylsulfatase family member H	Homo sapiens	153-162
11384867-3	2001	In the last years, it was demonstrated that various progestins (promegestone, nomegestrol acetate, medrogestone), as well as tibolone and its metabolites are potent inhibitors of sulfatase and 17beta-hydroxysteroid dehydrogenase activities.	Medrogestone	99-111	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	193-228
2156343-5	1990	Medrogestone had a synergistic effect on the lowering of FSH, LH and PRL.	Medrogestone	0-12	prolactin	Equus caballus	69-72
10543415-12	1999	This effect may be due to glucocorticoid receptor mediated actions of medrogestone on bone.	Medrogestone	70-82	nuclear receptor subfamily 3 group C member 1	Homo sapiens	26-49
10215037-0	1999	Effect of Medrogestone on 17beta-hydroxysteroid dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.	Medrogestone	10-22	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	26-61
10215037-3	1999	In the present study we explored the effect of Medrogestone (Prothil) on 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities of the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.	Medrogestone	47-59	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	73-108
10215037-3	1999	In the present study we explored the effect of Medrogestone (Prothil) on 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities of the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.	Medrogestone	47-59	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	110-120
10215037-3	1999	In the present study we explored the effect of Medrogestone (Prothil) on 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities of the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.	Medrogestone	61-68	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	73-108
10215037-3	1999	In the present study we explored the effect of Medrogestone (Prothil) on 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities of the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.	Medrogestone	61-68	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	110-120
10215037-7	1999	It is concluded that the inhibition provoked by Medrogestone on the reductive 17beta-HSD activity involved in the local biosynthesis of the biologically active estrogen estradiol, may constitute a new therapeutic approach for the treatment of breast cancer.	Medrogestone	48-60	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	78-88
9699877-7	1998	It was demonstrated that in the hormone-dependent breast cancer cells, various progestins (nomegestrol acetate, tibolone, medrogestone, promegestone) are potent sulfatase inhibitory agents.	Medrogestone	122-134	arylsulfatase family member H	Homo sapiens	161-170
10529001-0	1999	Control of sulfatase and sulfotransferase activities by medrogestone in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.	Medrogestone	56-68	arylsulfatase family member H	Homo sapiens	11-20
10529001-1	1999	In the present study, we explored the effect of the progestin medrogestone on the sulfatase and sulfotransferase activities in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.	Medrogestone	62-74	arylsulfatase family member H	Homo sapiens	82-91
10529001-10	1999	In conclusion, the inhibitory effect provoked by medrogestone on the enzyme involved in the biosynthesis of E2 (sulfatase pathway) in estrogen-dependent breast cancer, as well as the stimulatory effect on the formation of the inactive ES, support a probable anti-proliferative effect of this progestin in breast tissue.	Medrogestone	49-61	arylsulfatase family member H	Homo sapiens	112-121
12227897-6	1999	It was demonstrated that in hormone-dependent breast cancer cells, various progestins (nomegestrol acetate, medrogestone, promegestone) as well as tibolone, are potent sulfatase-inhibitory agents.	Medrogestone	108-120	arylsulfatase family member H	Homo sapiens	168-177