PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25856345-5 2015 Our results showed that nontoxic doses of LB are able to inhibit AKT activation in both luminal-like MCF-7 and basal-like MDA-MB-231 breast cancer cells. lb 42-44 AKT serine/threonine kinase 1 Homo sapiens 65-68 25950736-9 2015 The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of LB formation. lb 186-188 isopentenyl-diphosphate delta isomerase 1 Homo sapiens 34-38 25950736-9 2015 The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of LB formation. lb 186-188 isopentenyl-diphosphate delta isomerase 2 Homo sapiens 43-47 25950736-9 2015 The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of LB formation. lb 186-188 synuclein alpha Homo sapiens 136-151 26048993-9 2015 The role of StarD10 in trafficking of phospholipid to LB was confirmed by the observation that knockdown of StarD10 significantly reduced transport of phospholipid to LB. lb 54-56 StAR related lipid transfer domain containing 10 Homo sapiens 12-19 26048993-9 2015 The role of StarD10 in trafficking of phospholipid to LB was confirmed by the observation that knockdown of StarD10 significantly reduced transport of phospholipid to LB. lb 54-56 StAR related lipid transfer domain containing 10 Homo sapiens 108-115 26048993-9 2015 The role of StarD10 in trafficking of phospholipid to LB was confirmed by the observation that knockdown of StarD10 significantly reduced transport of phospholipid to LB. lb 167-169 StAR related lipid transfer domain containing 10 Homo sapiens 12-19 26048993-9 2015 The role of StarD10 in trafficking of phospholipid to LB was confirmed by the observation that knockdown of StarD10 significantly reduced transport of phospholipid to LB. lb 167-169 StAR related lipid transfer domain containing 10 Homo sapiens 108-115 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 141-144 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 epidermal growth factor receptor Homo sapiens 146-150 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 TEK receptor tyrosine kinase Homo sapiens 152-156 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 158-161 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 163-166 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 fibroblast growth factor receptor 1 Homo sapiens 174-179 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 181-184 25856345-9 2015 Finally, a small scale in vitro kinase assay screen demonstrated that LB has a potent inhibitory effect on multiple kinases, including PI3K, Src, EGFR, Tie2, lck, lyn, RTK5, FGFR1, Abl, and Flt. lb 70-72 fms related receptor tyrosine kinase 1 Homo sapiens 190-193 24706818-5 2014 Importantly, beta-CD treatment reduced by 73% and 48% the LB content of RPE cell cultures and of eyecups obtained from Abca4-Rdh8 double knock-out (DKO) mice, respectively. lb 58-60 beta-carotene oxygenase 1 Mus musculus 13-20 25565224-8 2015 In patients with EI, the cytoskeletal abnormality impairs the exocytosis of LB contents and thus results in decreased LL-37, HBD2, and KLK7 secretion, causing substantial entombment of these proteins within the corneocyte cytosol. lb 76-78 cathelicidin antimicrobial peptide Homo sapiens 118-123 25565224-8 2015 In patients with EI, the cytoskeletal abnormality impairs the exocytosis of LB contents and thus results in decreased LL-37, HBD2, and KLK7 secretion, causing substantial entombment of these proteins within the corneocyte cytosol. lb 76-78 defensin beta 4A Homo sapiens 125-129 25565224-8 2015 In patients with EI, the cytoskeletal abnormality impairs the exocytosis of LB contents and thus results in decreased LL-37, HBD2, and KLK7 secretion, causing substantial entombment of these proteins within the corneocyte cytosol. lb 76-78 kallikrein related peptidase 7 Homo sapiens 135-139 25667463-2 2015 Herein, we discuss the importance of LB-based nanocrystallography at the frontiers of cancer proteomics focusing on two model proteins with important biological roles in cancer, namely CK2alpha and RNase A. lb 37-39 casein kinase 2 alpha 2 Homo sapiens 185-193 25667463-2 2015 Herein, we discuss the importance of LB-based nanocrystallography at the frontiers of cancer proteomics focusing on two model proteins with important biological roles in cancer, namely CK2alpha and RNase A. lb 37-39 ribonuclease A family member 1, pancreatic Homo sapiens 198-205 25401511-11 2015 However, LB pathology in LRRK2-related PD may be a marker for a broader parkinsonian symptom complex including cognitive impairment. lb 9-11 leucine rich repeat kinase 2 Homo sapiens 25-30 25450800-5 2015 Moreover, recent studies have shown that the peroxisome proliferator-activated receptor gamma (PPAR-gamma) is implicated in LB formation and acts as an important modulator of lipid metabolism during inflammation. lb 124-126 peroxisome proliferator activated receptor gamma Mus musculus 95-105 25450800-7 2015 We demonstrate that TsV acts through TLR2 and TLR4 stimulation and PPAR-gamma activation to induce LB formation and generation of PGE2 and LTB4. lb 99-101 peroxisome proliferator activated receptor gamma Mus musculus 67-77 24555544-4 2014 The mixed LB/SB protocol was applied to virtually screen potential Hsp90 inhibitors from the NCI Diversity Set composed of 1785 compounds. lb 10-12 heat shock protein 90 alpha family class A member 1 Homo sapiens 67-72 24465451-13 2014 In summary our results suggest that LRRK2 -/- affects LB size, modulates intracellular Ca(2+) signaling and promotes LB exocytosis upon stimulation of ATII cells with ATP. lb 54-56 leucine-rich repeat kinase 2 Rattus norvegicus 36-41 25033953-7 2014 CONCLUSION: The TN(-/-) mouse exhibits several key features of PD and so may be a valuable model for studying LB formation and testing candidate neuroprotective therapies for PD and other synucleinopathies. lb 110-112 C-type lectin domain family 3, member b Mus musculus 16-18 24252552-11 2013 Moreover, the severe LB pathology suggests that dysfunction of the PLA2G6 gene primarily contributes to LB formation. lb 21-23 phospholipase A2 group VI Homo sapiens 67-73 24252552-11 2013 Moreover, the severe LB pathology suggests that dysfunction of the PLA2G6 gene primarily contributes to LB formation. lb 104-106 phospholipase A2 group VI Homo sapiens 67-73 23307836-3 2013 We recently reported that LB exocytosis results in fusion-activated cation entry (FACE) via P2X4 receptors on LBs. lb 26-28 purinergic receptor P2X 4 Homo sapiens 92-96 22701661-3 2012 How alpha-syn contributes to LB formation and PD is still not well-understood. lb 29-31 synuclein alpha Homo sapiens 4-13 23415729-8 2013 RESULTS: In the LB group, biopsies showed a significant presence of IL-17+ cells/mm2 of lamina propria compared with the stable, acute A-grade/chronic rejection and infection groups (p < 0.0001). lb 16-18 interleukin 17A Homo sapiens 68-73 23415729-10 2013 Azithromycin reduced both %BAL neutrophilia and IL-17+ cells (both p = 0.016) in the LB group. lb 85-87 interleukin 17A Homo sapiens 48-53 21605057-6 2011 By one-step affinity chromatography and on-column, auto-cleavage of the fusion tag, the mature DEFB103 peptide was produced with a yield of 30 mg/L LB. lb 148-150 defensin beta 103A Homo sapiens 95-102 21960119-4 2011 The differential charging in the LB multilayers changes after sulfidation due to the formation of cadmium sulfide nanostructures in the cadmium arachidate LB matrix, which was reflected prominently in the differential charging of Cd 3d(5/2) XPS peaks. lb 33-35 CD3 delta subunit of T-cell receptor complex Homo sapiens 230-235 21844344-12 2011 Furthermore, analysis of fluorophore diffusion into and out of individual vesicles after exocytotic fusion provides evidence that FACE regulates postfusion events of LB exocytosis via P2X(4). lb 166-168 purinergic receptor P2X 4 Homo sapiens 184-190 20720502-8 2010 The localization of LRRK2 protein in the core of a subset of LBs demonstrates the contribution of LRRK2 to LB formation and disease pathogenesis. lb 61-63 leucine rich repeat kinase 2 Homo sapiens 20-25 21669009-6 2011 This increase in the luminal surface area correlated with the decrease in surface area of Lb per AE2. lb 90-92 solute carrier family 4 member 2 Rattus norvegicus 97-100 21669009-8 2011 CONCLUSION: We suggest that in this animal model the reduction of the number of Lb per AE2 cell is most likely due to stimulated exocytosis of Lb into the alveolar space. lb 80-82 solute carrier family 4 member 2 Rattus norvegicus 87-90 21669009-8 2011 CONCLUSION: We suggest that in this animal model the reduction of the number of Lb per AE2 cell is most likely due to stimulated exocytosis of Lb into the alveolar space. lb 143-145 solute carrier family 4 member 2 Rattus norvegicus 87-90 21669009-9 2011 The loss of Lb is partly compensated by an increased size of Lb thus maintaining total volume of Lb per AE2 cell and lung. lb 12-14 solute carrier family 4 member 2 Rattus norvegicus 104-107 21669009-9 2011 The loss of Lb is partly compensated by an increased size of Lb thus maintaining total volume of Lb per AE2 cell and lung. lb 61-63 solute carrier family 4 member 2 Rattus norvegicus 104-107 21669009-9 2011 The loss of Lb is partly compensated by an increased size of Lb thus maintaining total volume of Lb per AE2 cell and lung. lb 61-63 solute carrier family 4 member 2 Rattus norvegicus 104-107 21185158-6 2011 We found that plasma membrane conformational changes causing LB secretion are controlled by PAR-2-dependent cytoskeletal rearrangements. lb 61-63 coagulation factor II (thrombin) receptor-like 1 Mus musculus 92-97 20720502-8 2010 The localization of LRRK2 protein in the core of a subset of LBs demonstrates the contribution of LRRK2 to LB formation and disease pathogenesis. lb 61-63 leucine rich repeat kinase 2 Homo sapiens 98-103 19005485-10 2009 These studies demonstrate that cav-1 delivery to the APM by LB trafficking to APM "brakes" further LB secretion, signals terminal differentiation, and regulates epidermal hyperproliferation. lb 60-62 caveolin 1, caveolae protein Mus musculus 31-36 19880756-3 2009 When starch biosynthesis is blocked in the sta6 mutant, the LB content increases 30-fold, demonstrating that genetic manipulation can enhance LB production. lb 60-62 uncharacterized protein Chlamydomonas reinhardtii 43-47 19880756-3 2009 When starch biosynthesis is blocked in the sta6 mutant, the LB content increases 30-fold, demonstrating that genetic manipulation can enhance LB production. lb 142-144 uncharacterized protein Chlamydomonas reinhardtii 43-47 20678197-12 2010 When sterile-filtered LB supernatants, which formerly contained relatively low concentrations of bacteria(1,000-10,000 CFU mL-1), were employed as a diluent, there was an evident shift of the two populations towards each other but the bimodal effect was still apparent using either stationary or log phase cells. lb 22-24 L1 cell adhesion molecule Mus musculus 123-127 20559033-8 2010 CONCLUSIONS: LB is associated with inadequate suppression of peripheral blood T-cell granzyme B, IFN-gamma, and TNF-alpha. lb 13-15 granzyme B Homo sapiens 85-95 20559033-8 2010 CONCLUSIONS: LB is associated with inadequate suppression of peripheral blood T-cell granzyme B, IFN-gamma, and TNF-alpha. lb 13-15 interferon gamma Homo sapiens 97-106 20559033-8 2010 CONCLUSIONS: LB is associated with inadequate suppression of peripheral blood T-cell granzyme B, IFN-gamma, and TNF-alpha. lb 13-15 tumor necrosis factor Homo sapiens 112-121 19762560-3 2010 However, the roles of alpha-Syn-Sph1 interaction in LB formation and in the related pathogenesis are still unclear. lb 52-54 synuclein alpha interacting protein Homo sapiens 32-36 19762560-7 2010 These observations demonstrate that the alpha-Syn-Sph1 interaction significantly promotes the formation of cytoplasmic alpha-Syn inclusions, which may have implications for LB formation in neural cells. lb 173-175 synemin Homo sapiens 46-49 19762560-7 2010 These observations demonstrate that the alpha-Syn-Sph1 interaction significantly promotes the formation of cytoplasmic alpha-Syn inclusions, which may have implications for LB formation in neural cells. lb 173-175 synuclein alpha interacting protein Homo sapiens 50-54 19762560-7 2010 These observations demonstrate that the alpha-Syn-Sph1 interaction significantly promotes the formation of cytoplasmic alpha-Syn inclusions, which may have implications for LB formation in neural cells. lb 173-175 synuclein alpha Homo sapiens 40-49 19299700-10 2009 In agreement with this hypothesis, beta-glucan-elicited LB formation was inhibited in leukocytes from 5-LO(-/-), CD18(low) and TLR2(-/-) mice, as well as in leukocytes pretreated with anti-Dectin-1 Ab. lb 56-58 integrin beta 2 Mus musculus 113-117 19299700-10 2009 In agreement with this hypothesis, beta-glucan-elicited LB formation was inhibited in leukocytes from 5-LO(-/-), CD18(low) and TLR2(-/-) mice, as well as in leukocytes pretreated with anti-Dectin-1 Ab. lb 56-58 toll-like receptor 2 Mus musculus 127-131 19437773-6 2009 With fluorescence spectroscopy it was possible to confirm that the ADH structure was preserved even after one month of the LB deposition. lb 123-125 aldo-keto reductase family 1 member A1 Homo sapiens 67-70 18622020-9 2008 Western blotting confirmed the presence of CLIP-170 and its known effectors IQGAP1 and Cdc42 in the LB-enriched fraction. lb 100-102 CAP-Gly domain containing linker protein 1 Homo sapiens 43-51 18622020-9 2008 Western blotting confirmed the presence of CLIP-170 and its known effectors IQGAP1 and Cdc42 in the LB-enriched fraction. lb 100-102 IQ motif containing GTPase activating protein 1 Homo sapiens 76-82 18622020-9 2008 Western blotting confirmed the presence of CLIP-170 and its known effectors IQGAP1 and Cdc42 in the LB-enriched fraction. lb 100-102 cell division cycle 42 Homo sapiens 87-92 17884071-9 2007 And the PLG was believed to be compelled to the up layer of the LB film due to the phase separation, which is examined by AFM. lb 64-66 plasminogen Homo sapiens 8-11 17943185-6 2008 Despite an apparent increase in mBD3 protein, CRAMP-/- mice delayed permeability barrier recovery, attributable to defective LB contents and abnormalities in the structure of the lamellar membranes that regulate permeability barrier function. lb 125-127 cathelicidin antimicrobial peptide Mus musculus 46-51 18788765-3 2008 The results show the outer membrane leaflet mimic (DPPC/cholesterol/glycophorin A LB film) consisting of a single homogeneous phase whereas the inner membrane leaflet mimic (DPPE/cholesterol/glycophorin A LB film) displays heterogeneity in the form of two separate phases. lb 82-84 glycophorin A (MNS blood group) Homo sapiens 68-81 17971075-5 2008 We also examined the pattern of LRRK2 expression in relation to alpha-synuclein aggregation and LB formation in the brainstem of sporadic LB disease. lb 96-98 leucine rich repeat kinase 2 Homo sapiens 32-37 18172022-7 2008 Because vesicular clustering is also found in LB-containing neurons of PD brains, alpha-syn-mediated vesicular accumulation in yeast represents a model system to study specific aspects of neurodegeneration in PD and related synucleinopathies. lb 46-48 synuclein alpha Homo sapiens 82-91 18276962-7 2008 Correlations of beta-amyloid and of LB density with synaptophysin score were unimpressive. lb 36-38 synaptophysin Homo sapiens 52-65 18802494-5 2007 SRB is incorporated into positively charged LB layers of ODA by immersing the ODA deposited substrates into aqueous solution of SRB. lb 44-46 chaperonin containing TCP1 subunit 4 Homo sapiens 0-3 16386250-4 2006 Recently, valosin-containing protein (VCP) was one of the components of LBs, suggesting its involvement in LB formation. lb 72-74 valosin containing protein Homo sapiens 38-41 17042541-8 2006 AFM imaging confirmed the formation of PCL crystals in the LB monolayers of the PCL homopolymers and of the copolymers, but also showed that the PCL segments can undergo additional crystallization after monolayer transfer during water evaporation. lb 59-61 PHD finger protein 1 Homo sapiens 39-42 17042541-8 2006 AFM imaging confirmed the formation of PCL crystals in the LB monolayers of the PCL homopolymers and of the copolymers, but also showed that the PCL segments can undergo additional crystallization after monolayer transfer during water evaporation. lb 59-61 PHD finger protein 1 Homo sapiens 80-83 17042541-8 2006 AFM imaging confirmed the formation of PCL crystals in the LB monolayers of the PCL homopolymers and of the copolymers, but also showed that the PCL segments can undergo additional crystallization after monolayer transfer during water evaporation. lb 59-61 PHD finger protein 1 Homo sapiens 80-83 16374473-8 2006 Thus, topical PPAR and LXR activators stimulate epidermal lipid synthesis, increase LB secretion, and accelerate extracellular lipid processing, providing additional mechanisms that further account for their ability to improve epidermal permeability barrier homeostasis. lb 84-86 peroxisome proliferator activated receptor alpha Mus musculus 14-18 16374473-8 2006 Thus, topical PPAR and LXR activators stimulate epidermal lipid synthesis, increase LB secretion, and accelerate extracellular lipid processing, providing additional mechanisms that further account for their ability to improve epidermal permeability barrier homeostasis. lb 84-86 nuclear receptor subfamily 1, group H, member 3 Mus musculus 23-26 16691196-10 2006 These results demonstrate first, the importance of SP/SPI balance for normal permeability barrier homeostasis, and second, they identify PAR-2 as a novel signaling mechanism of permeability barrier, that is, of response linked to LB secretion. lb 230-232 coagulation factor II (thrombin) receptor-like 1 Mus musculus 137-142 16386250-4 2006 Recently, valosin-containing protein (VCP) was one of the components of LBs, suggesting its involvement in LB formation. lb 72-74 valosin containing protein Homo sapiens 10-36 15353226-6 2004 Collectively, these findings suggest that increased PDIp expression in dopaminergic (DA) neurons might contribute to LB formation and neurodegeneration, and that this increased PDIp expression may be the result of proteasome impairment. lb 117-119 protein disulfide isomerase family A member 2 Homo sapiens 52-56 16423277-13 2006 [35S]SP-B was transported and stored to the LB via the Golgi-dependent pathway. lb 44-46 surfactant protein B Rattus norvegicus 5-9 16187065-12 2005 Our results support the concept that postnatal alveolarization in rat lungs is associated with significant increases in the SP-B content in lb and volume fraction of lb in type II pneumocytes. lb 140-142 surfactant protein B Rattus norvegicus 124-128 16187065-12 2005 Our results support the concept that postnatal alveolarization in rat lungs is associated with significant increases in the SP-B content in lb and volume fraction of lb in type II pneumocytes. lb 166-168 surfactant protein B Rattus norvegicus 124-128 16002471-4 2005 We further show that the accumulation of LBs near phagosomes is mediated at least in part by the flavohemoprotein gp91phox (in which "phox" is phagocyte oxidase), because different LB distributions around phagocytosed latex beads were observed in WT and gp91phox-deficient PLB-985 cells. lb 41-43 cytochrome b-245 beta chain Homo sapiens 114-122 16002471-4 2005 We further show that the accumulation of LBs near phagosomes is mediated at least in part by the flavohemoprotein gp91phox (in which "phox" is phagocyte oxidase), because different LB distributions around phagocytosed latex beads were observed in WT and gp91phox-deficient PLB-985 cells. lb 41-43 cytochrome b-245 beta chain Homo sapiens 254-262 18028621-3 2005 Films of LB-deposited C13-PTCDI were found to be completely isotropic prior to annealing. lb 9-11 homeobox C13 Homo sapiens 22-31 15833699-6 2005 Comparison with previous literature reports indicate that for Nafion the LB coating procedure is unique in keeping the electroactivity of cyt c. lb 73-75 cytochrome c, somatic Homo sapiens 138-143 11509723-2 2001 LB films deposited from the hexagonal phase of cadmium arachidate (CdA2) at pH 7 spontaneously transform into the bulk soap structure, a centrosymmetric bilayer with an orthorhombic herringbone packing. lb 0-2 activation induced cytidine deaminase Homo sapiens 67-71 15743078-3 2004 The SFG spectra in air are virtually identical and are independent of the odd-even property and thickness (1-12) of the LB films, indicating that the even-numbered LB film changes its surface structure after passing through the interface between the water subphase and air, especially when the Cd2+ cation was included in the water subphase. lb 164-166 CD2 molecule Homo sapiens 294-297 14670494-4 2004 LB films were deposited onto Ag nanoparticles to achieve the surface-enhanced pre-resonance Raman scattering (pre-SERRS) and surface-enhanced Raman scattering (SERS) for both laser lines, respectively, which allowed the characterization of the RhPc ultra thin films. lb 0-2 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 114-119 12750386-11 2003 These results suggest that the central domain of synphilin-1 has an important role in the formation of aggregates and cytotoxicity and that Dorfin may be involved in the pathogenic process of PD and LB formation by ubiquitylation of synphilin-1. lb 199-201 synuclein alpha interacting protein Homo sapiens 49-60 12750386-11 2003 These results suggest that the central domain of synphilin-1 has an important role in the formation of aggregates and cytotoxicity and that Dorfin may be involved in the pathogenic process of PD and LB formation by ubiquitylation of synphilin-1. lb 199-201 synuclein alpha interacting protein Homo sapiens 233-244 12410385-2 2002 Although the pathogenic role of alpha-synuclein in AD remains unclear, LB formation might be associated with pathological beta-amyloid (Abeta) overproduction. lb 71-73 amyloid beta precursor protein Homo sapiens 122-142 12410385-7 2002 These findings suggest that (1) LB pathology can influence the clinical features of familial AD, (2) the E184D mutation of presenilin-1 may be associated with the LB formation through Abeta overproduction, although the process of LB formation is strongly affected by other unknown mechanisms, (3) in neurodegenerative disorders with LBs, there is a common pathophysiological background inducing NAC accumulation in neuritic plaques and astrocytes, and (4) the NAC accumulation in neuritic plaques is modulated by the abnormally aggregated tau protein. lb 32-34 presenilin 1 Homo sapiens 123-135 12410385-7 2002 These findings suggest that (1) LB pathology can influence the clinical features of familial AD, (2) the E184D mutation of presenilin-1 may be associated with the LB formation through Abeta overproduction, although the process of LB formation is strongly affected by other unknown mechanisms, (3) in neurodegenerative disorders with LBs, there is a common pathophysiological background inducing NAC accumulation in neuritic plaques and astrocytes, and (4) the NAC accumulation in neuritic plaques is modulated by the abnormally aggregated tau protein. lb 163-165 presenilin 1 Homo sapiens 123-135 12410385-7 2002 These findings suggest that (1) LB pathology can influence the clinical features of familial AD, (2) the E184D mutation of presenilin-1 may be associated with the LB formation through Abeta overproduction, although the process of LB formation is strongly affected by other unknown mechanisms, (3) in neurodegenerative disorders with LBs, there is a common pathophysiological background inducing NAC accumulation in neuritic plaques and astrocytes, and (4) the NAC accumulation in neuritic plaques is modulated by the abnormally aggregated tau protein. lb 163-165 presenilin 1 Homo sapiens 123-135 11679273-5 2001 AChE-immobilized LB film was formed by adsorbing the enzyme molecules onto a viologen monolayer using the electrostatic force. lb 17-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 11270609-11 2001 At 12 hr and 24 hr, iNOS positive cells in the LB group by infection of LFn were identified and shown to contain mostly macrophages. lb 47-49 nitric oxide synthase 2, inducible Mus musculus 20-24 10799694-5 2000 These data suggest that Cdk5 may be associated with LB formation. lb 52-54 cyclin dependent kinase 5 Homo sapiens 24-28 11045680-7 2000 These findings give further evidence that accumulation of alpha-synuclein is generally associated with LB formation, i.e., in Parkinson"s disease, dementia with Lewy bodies and NBIA-1. lb 103-105 synuclein alpha Homo sapiens 58-73 11045680-7 2000 These findings give further evidence that accumulation of alpha-synuclein is generally associated with LB formation, i.e., in Parkinson"s disease, dementia with Lewy bodies and NBIA-1. lb 103-105 pantothenate kinase 2 Homo sapiens 177-183 9795161-4 1998 The NACP-immunoreactive perikaryal threads, consisting of small bundles of LB-filaments and randomly oriented LB-filaments, presumably represent an initial stage of LB- or PB-formation. lb 75-77 synuclein alpha Homo sapiens 4-8 10799694-4 2000 Immunoelectron microscopy revealed Cdk5-immunolabeled granulo-filamentous components in LBs and LB-related neurites. lb 88-90 cyclin dependent kinase 5 Homo sapiens 35-39 9600590-4 1998 Moreover, plaque density in the temporal cortex and LB density in the cingulate cortex were significantly higher in the group with APOE4 than in that without the allele. lb 52-54 apolipoprotein E Homo sapiens 131-136 9759660-3 1998 Furthermore, studies of the subcellular localization of NACP/alpha-synuclein within LB-bearing neurons were performed by immunogold electron microscopy. lb 84-86 synuclein alpha Homo sapiens 56-60 9759660-3 1998 Furthermore, studies of the subcellular localization of NACP/alpha-synuclein within LB-bearing neurons were performed by immunogold electron microscopy. lb 84-86 synuclein alpha Homo sapiens 61-76 7676802-6 1995 Our results showed that SOD1-like immunoreactivity occurred frequently in LBs and LIs, suggesting that a common cytopathological process is responsible for the formation of LB-type neuronal intracytoplasmic inclusions. lb 74-76 superoxide dismutase 1 Homo sapiens 24-28 8613362-8 1996 In contrast, culture supernatants from LB-grown EHEC isolates that produced SLT-I, SLT-II, SLT-IIc or SLT-IIe did not show increased cytotoxicity after incubation with mouse or human intestinal mucus. lb 39-41 dopachrome tautomerase Mus musculus 76-79 8613362-8 1996 In contrast, culture supernatants from LB-grown EHEC isolates that produced SLT-I, SLT-II, SLT-IIc or SLT-IIe did not show increased cytotoxicity after incubation with mouse or human intestinal mucus. lb 39-41 dopachrome tautomerase Mus musculus 83-86 8613362-8 1996 In contrast, culture supernatants from LB-grown EHEC isolates that produced SLT-I, SLT-II, SLT-IIc or SLT-IIe did not show increased cytotoxicity after incubation with mouse or human intestinal mucus. lb 39-41 dopachrome tautomerase Mus musculus 83-86 8613362-8 1996 In contrast, culture supernatants from LB-grown EHEC isolates that produced SLT-I, SLT-II, SLT-IIc or SLT-IIe did not show increased cytotoxicity after incubation with mouse or human intestinal mucus. lb 39-41 dopachrome tautomerase Mus musculus 83-86 1281203-9 1992 The gamma-GT was associated with LB whereas GP2 was found in the lumen but not associated with these structures. lb 33-35 gamma-glutamyltransferase 1 Rattus norvegicus 4-12 8169200-5 1994 The delay in the induction of transcription of sigma 54-dependent promoters reflects catabolite inhibition exerted by LB components, since the addition of yeast extracts, Casamino Acids, or several combinations of amino acids dramatically inhibited the synthesis of XylR-controlled sigma 54-dependent promoters. lb 118-120 xylose operon regulatory protein Pseudomonas putida 266-270 8525803-15 1995 The fact that extracellular tangle material can act as a nidus for BAP build-up in LB suggests that further consideration needs to be given to the ways in which extracellular BAP deposits are formed. lb 83-85 SIL1 nucleotide exchange factor Homo sapiens 67-70 8525803-15 1995 The fact that extracellular tangle material can act as a nidus for BAP build-up in LB suggests that further consideration needs to be given to the ways in which extracellular BAP deposits are formed. lb 83-85 SIL1 nucleotide exchange factor Homo sapiens 175-178 34967032-2 2022 The aim of this study is to evaluate the accuracy of the commercial LB in detection of antinuclear matrix protein 2 (NXP2) antibody. lb 68-70 MORC family CW-type zinc finger 3 Homo sapiens 117-121 1571254-6 1992 Despite normal quantities of LB in CIE, EFAD, and mouse tail epidermis, lipase activity was markedly deficient both in LB and in the SC intercellular domains. lb 119-121 lipase, endothelial Mus musculus 72-78 34967032-9 2022 In conclusion, the LB showed low sensitivity for detection of anti-NXP2 antibody, an effect exacerbated at low titers of anti-NXP2 antibodies. lb 19-21 MORC family CW-type zinc finger 3 Homo sapiens 67-71 34962634-5 2022 Deletion of p62 prevented LB accumulation in skeletal muscle and cardiac tissue. lb 26-28 nucleoporin 62 Mus musculus 12-15 34962634-6 2022 In the brain, the absence of p62 altered LB morphology and increased susceptibility to epilepsy. lb 41-43 nucleoporin 62 Mus musculus 29-32 34890628-10 2022 Another consequence of the model is the prediction that removing alpha-syn aggregates from the brain after the aggregation of membrane-bound organelles into LBs has started may not stop the progression of PD because LB formation is an autocatalytic process; hence, the formation of LBs will be catalyzed by aggregates of membrane-bound organelles even in the absence of alpha-syn aggregates. lb 216-218 synuclein alpha Homo sapiens 65-74 34819159-6 2021 Direct interrogation of the cellular response to LB-derived alpha-Syn has thus far been limited. lb 49-51 synuclein alpha Homo sapiens 60-69 34077533-5 2021 The amount of surfactant protein C was significantly decreased in the bronchoalveolar lavage fluid obtained from Lrrk2 KO mice, suggesting that LB exocytosis is impaired in Lrrk2 KO mice. lb 144-146 leucine-rich repeat kinase 2 Mus musculus 113-118 34135015-2 2021 RESEARCH DESIGN AND METHODS: Glucagon was measured in three randomized, parallel, clinical studies: 1) 91 youth studied at baseline, after 12 months on metformin alone (MET) or glargine followed by metformin (G/M), and 3 months after treatment withdrawal; 2) 267 adults studied at the same time points and treated with MET, G/M, or liraglutide plus metformin (L+M) or given placebo (PLAC); and 3) 88 adults studied at baseline and after 12 and 24 months of LB or MET. lb 457-459 glucagon Homo sapiens 29-37 34135015-7 2021 LB in adults also reduced fasting glucagon, steady-state glucagon, and AGR at 12 and 24 months (P < 0.05 for all, except AGR at 12 months (P = 0.098)). lb 0-2 glucagon Homo sapiens 34-42 34135015-7 2021 LB in adults also reduced fasting glucagon, steady-state glucagon, and AGR at 12 and 24 months (P < 0.05 for all, except AGR at 12 months (P = 0.098)). lb 0-2 glucagon Homo sapiens 57-65 34077533-5 2021 The amount of surfactant protein C was significantly decreased in the bronchoalveolar lavage fluid obtained from Lrrk2 KO mice, suggesting that LB exocytosis is impaired in Lrrk2 KO mice. lb 144-146 leucine-rich repeat kinase 2 Mus musculus 173-178 34077533-8 2021 Our findings implicate the LRRK2-BORCS6 pathway in the maintenance of LB morphology. lb 70-72 leucine rich repeat kinase 2 Homo sapiens 27-32 34077533-8 2021 Our findings implicate the LRRK2-BORCS6 pathway in the maintenance of LB morphology. lb 70-72 BLOC-1 related complex subunit 6 Mus musculus 33-39 34043198-4 2021 Injection of animals with alpha-Syn preformed fibrils (PFFs) can recapitulate LB-like inclusions and the subsequent intercellular transmission of alpha-Syn pathology. lb 78-80 synuclein, alpha Mus musculus 26-35 35396971-6 2022 PERK activation and LB formation are both crucial for SBA-induced cross-presentation and PERK inhibition has little or no effect on SBA-induced LB formation. lb 20-22 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 89-93 35303923-8 2022 The results showed that the levels of the genes in the Nrf2/HO-1 pathway in the chickens in the LB(+) groups were higher than those in the LB(-) groups (p < 0.001); those in the H/LB(+) group were higher than those in the M/LB(+) and L/LB(+) groups (p < 0.001); and those in the H/EA + H/LB(+) group showed the highest expression levels compared with the other groups (p < 0.001). lb 96-98 heme oxygenase 1 Gallus gallus 60-64 34121225-2 2021 Here, we report a case of PD with a PARK2 mutation characterized by a homozygous deletion of exon 2 and incidental LB pathology. lb 115-117 parkin RBR E3 ubiquitin protein ligase Homo sapiens 36-41 35579337-7 2022 The anti-TIF1-gamma results from the in-house ELISA were confirmed with IP in 93 of 101 (92%) cases, kappa = 0.76, with a commercial ELISA in 110 of 131 (84%) cases, kappa = 0.63 and with LB in 101 of 113 (89.3%) cases, kappa = 0.67. lb 188-190 tripartite motif containing 33 Homo sapiens 9-19 35073709-9 2022 In the LB/MIX group, 48 (22.6%) were Asian and 164 (77.4%) were Caucasian. lb 7-9 Mix paired-like homeobox Homo sapiens 10-13 35092577-15 2022 NXP2 positivity by LB should be confirmed by other methods in order to correctly diagnose and characterize patients affected by idiopathic inflammatory myositis. lb 19-21 MORC family CW-type zinc finger 3 Homo sapiens 0-4 35173542-7 2022 Both autophagy-related gene 7 (Atg7) global knockout and conditional Atg7 knockdown in AT2 cells in mice led to defects in LB maturation and surfactant protein B production. lb 123-125 autophagy related 7 Mus musculus 5-29 35173542-7 2022 Both autophagy-related gene 7 (Atg7) global knockout and conditional Atg7 knockdown in AT2 cells in mice led to defects in LB maturation and surfactant protein B production. lb 123-125 autophagy related 7 Mus musculus 31-35 35173542-7 2022 Both autophagy-related gene 7 (Atg7) global knockout and conditional Atg7 knockdown in AT2 cells in mice led to defects in LB maturation and surfactant protein B production. lb 123-125 autophagy related 7 Mus musculus 69-73 33846345-5 2021 We next compare these findings to those associated with LB-like inclusions initiated by in vitro exposure to alpha-syn preformed fibrils (PFFs) and highlight the profound and relatively unique reduction of brain-derived neurotrophic factor (BDNF) in this model. lb 56-58 synuclein alpha Homo sapiens 109-118 33515275-2 2021 alpha-Synuclein aggregation is thought to be a critical pathogenic event in the aetiology of LB disease, based on genetic analyses, fundamental studies using model systems, and the observation of LB pathology in post-mortem tissue. lb 93-95 synuclein alpha Homo sapiens 0-15 33515275-5 2021 These findings are discussed in the context of known mediators of alpha-synuclein aggregation, highlighting the potential influence of impairments to these processes in the aetiology of LB formation. lb 186-188 synuclein alpha Homo sapiens 66-81 33432241-2 2021 Increasing evidence suggests that the aggregation of alpha-syn has a central role in LB formation and is one of the key processes that drive neurodegeneration and pathology progression in Parkinson disease. lb 85-87 synuclein alpha Homo sapiens 53-62 32150563-8 2020 In summary, this study describes a novel interstitial lung disease in dogs, identifies a new candidate gene for human surfactant dysfunction and brings important insights into the essential role of LAMP3 in the process of the LB formation. lb 226-228 lysosomal associated membrane protein 3 Homo sapiens 198-203 33277363-11 2021 Skeletal muscle analysis confirmed that Gys1 knockout inhibits glycogen and LB accumulation. lb 76-78 glycogen synthase 1, muscle Mus musculus 40-44 33105359-10 2020 For BDNF, effect sizes were largest in the LB (1.4), followed by the FB (0.75), and moderate to UB (0.33), although no significant differences were observed between conditions. lb 43-45 brain derived neurotrophic factor Homo sapiens 4-8 33272193-6 2020 RESULT: Deletion of the aspA gene in P. multocida resulted in a significant reduction in bacterial growth in LB (Luria-Bertani) and MH (Mueller-Hinton) media, which was rescued by supplementation with 20 mM fumarate. lb 109-111 aspartate ammonia-lyase Pasteurella multocida 24-28 33146466-10 2020 Compared to LA and LB, TN and HER2 patients had worse palliative outcomes; higher rates of incomplete courses at 18.8% and 18.3% versus 12.7%-14.4%; higher 30-day mortality post-radiotherapy at 21.5% and 16.0% versus 6.3%-7.9%, and higher median PRLSRT of 7.7% and 3.7% versus 2.2%-2.4% for LA and LB. lb 298-300 erb-b2 receptor tyrosine kinase 2 Homo sapiens 30-34 32692310-5 2020 LB accelerated the developmental emergence of parvalbumin (PV)-positive cells in the BLA and increased anatomical connections between PL and BLA. lb 0-2 parvalbumin Mus musculus 46-57 32624505-3 2020 Direct phosphorylation of alpha-synuclein at multiple Ser/Tyr residues is known to induce its aggregation, consequently promoting LB formation. lb 130-132 synuclein alpha Homo sapiens 26-41 31108396-4 2019 LB population exposed to WAF showed a significant increase in GSH content, CAT and CYP450 activities, compared to control group. lb 0-2 catalase Homo sapiens 75-78 31240397-8 2019 Further, change in concentration following training was larger between UB + LB and either LB or UB alone for both follistatin and myostatin. lb 76-78 myostatin Homo sapiens 130-139 31240397-8 2019 Further, change in concentration following training was larger between UB + LB and either LB or UB alone for both follistatin and myostatin. lb 90-92 myostatin Homo sapiens 130-139 32075919-4 2020 Toward this goal, we further developed a seeding-based model of alpha-syn fibrillization to generate a neuronal model that reproduces the key events leading to LB formation, including seeding, fibrillization, and the formation of inclusions that recapitulate many of the biochemical, structural, and organizational features of bona fide LBs. lb 160-162 synuclein alpha Homo sapiens 64-73 32075919-6 2020 In addition, we demonstrate that LB formation involves a complex interplay between alpha-syn fibrillization, posttranslational modifications, and interactions between alpha-syn aggregates and membranous organelles, including mitochondria, the autophagosome, and endolysosome. lb 33-35 synuclein alpha Homo sapiens 83-92 32075919-6 2020 In addition, we demonstrate that LB formation involves a complex interplay between alpha-syn fibrillization, posttranslational modifications, and interactions between alpha-syn aggregates and membranous organelles, including mitochondria, the autophagosome, and endolysosome. lb 33-35 synuclein alpha Homo sapiens 167-176 30660668-3 2019 We have previously demonstrated that LB biogenesis is controlled by the Rab11a guanosine triphosphate hydrolase, known for its ability to recruit the Myo5b motor. lb 37-39 RAB11A, member RAS oncogene family Homo sapiens 72-78 30660668-3 2019 We have previously demonstrated that LB biogenesis is controlled by the Rab11a guanosine triphosphate hydrolase, known for its ability to recruit the Myo5b motor. lb 37-39 myosin VB Homo sapiens 150-155 30660668-7 2019 In reconstructed human epidermis, Myo5b silencing led to epidermal barrier defects associated with structural alterations of the stratum corneum and a reduced pool of LB showing signs of disordered maturation. lb 167-169 myosin VB Homo sapiens 34-39 31516976-4 2019 Methods: We retrospectively compared pain control in a group of 75 patients with ACB and PAI with SB to that of a cohort of 75 patients who received ACB and PAI with LB. lb 166-168 serpin family E member 1 Homo sapiens 157-160 30773483-5 2019 By live cell imaging, the LB dynamics were visualized and altered distribution, enlargement, and impaired secretion of LBs were demonstrated in HPS2-iPSC-derived AT2 cells. lb 26-28 trefoil factor 1 Homo sapiens 144-148 30773483-5 2019 By live cell imaging, the LB dynamics were visualized and altered distribution, enlargement, and impaired secretion of LBs were demonstrated in HPS2-iPSC-derived AT2 cells. lb 26-28 angiotensin II receptor type 2 Homo sapiens 162-165 30605288-12 2018 A combination of LF and LB supplementation elicited maxi- mal up-regulation of Tollip, TLR4, IL-5, and IL-6 gene expression compared with other groups. lb 24-26 LOC101106506 Ovis aries 79-85 30113764-10 2018 The use of a MFI antigen ratio of the most discriminating markers (CD81/CD58) (analysis of variance, P < 0.005) increased the distinction of LB versus HG with a high specificity and sensitivity as demonstrated by the use of ROC curve analysis (AUC of CD81/CD58: 0.995). lb 144-146 CD81 molecule Homo sapiens 254-258 30113764-10 2018 The use of a MFI antigen ratio of the most discriminating markers (CD81/CD58) (analysis of variance, P < 0.005) increased the distinction of LB versus HG with a high specificity and sensitivity as demonstrated by the use of ROC curve analysis (AUC of CD81/CD58: 0.995). lb 144-146 CD58 molecule Homo sapiens 259-263 30113764-10 2018 The use of a MFI antigen ratio of the most discriminating markers (CD81/CD58) (analysis of variance, P < 0.005) increased the distinction of LB versus HG with a high specificity and sensitivity as demonstrated by the use of ROC curve analysis (AUC of CD81/CD58: 0.995). lb 144-146 CD81 molecule Homo sapiens 67-71 30113764-10 2018 The use of a MFI antigen ratio of the most discriminating markers (CD81/CD58) (analysis of variance, P < 0.005) increased the distinction of LB versus HG with a high specificity and sensitivity as demonstrated by the use of ROC curve analysis (AUC of CD81/CD58: 0.995). lb 144-146 CD58 molecule Homo sapiens 72-76 30605288-12 2018 A combination of LF and LB supplementation elicited maxi- mal up-regulation of Tollip, TLR4, IL-5, and IL-6 gene expression compared with other groups. lb 24-26 toll-like receptor 4 Ovis aries 87-91 30605288-12 2018 A combination of LF and LB supplementation elicited maxi- mal up-regulation of Tollip, TLR4, IL-5, and IL-6 gene expression compared with other groups. lb 24-26 interleukin-5 Ovis aries 93-97 30605288-12 2018 A combination of LF and LB supplementation elicited maxi- mal up-regulation of Tollip, TLR4, IL-5, and IL-6 gene expression compared with other groups. lb 24-26 interleukin-6 Ovis aries 103-107 29966337-8 2018 LB affected the cellular proliferation by increasing 10 times (Fc) the NF1 gene encoding for the neurofibromin protein, a tumor suppressor that prevent cells from uncontrolled proliferation. lb 0-2 neurofibromin 1 Homo sapiens 71-74 29966337-8 2018 LB affected the cellular proliferation by increasing 10 times (Fc) the NF1 gene encoding for the neurofibromin protein, a tumor suppressor that prevent cells from uncontrolled proliferation. lb 0-2 neurofibromin 1 Homo sapiens 97-110 29216576-7 2018 FINDINGS: LB adsorption on calcite surfaces was found to be significantly increased when blended with IOS or L38 since it forms surfactant complexes that partition to the surface. lb 10-12 ribosomal protein L38 Homo sapiens 109-112 29751824-6 2018 RESULTS: The mice inoculated with alpha-Syn PFFs, but not with PBS, developed phosphorylated alpha-Syn (p-alpha-Syn)-positive LB-like aggregates in the dmX at 45 days postinoculation. lb 126-128 joined toes Mus musculus 40-43 29325094-1 2018 Adenosine triphosphate (ATP)-binding cassette subfamily A member 3 (ABCA3), a phospholipid transporter in lung lamellar bodies (LBs), is essential for the assembly of pulmonary surfactant and LB biogenesis. lb 128-130 ATP binding cassette subfamily A member 3 Homo sapiens 68-73 29434298-8 2018 P62 aggregates derived from an autophagic defect might serve as "seeds" and can potentially be cause of LB formation. lb 104-106 nucleoporin 62 Mus musculus 0-3 27194917-5 2016 One hypothesis on LB formation is based on findings that laforin-malin complex downregulates glycogen synthase (GS) through malin-mediated ubiquitination, and the other one is based on findings that laforin dephosphorylates glycogen. lb 18-20 NHL repeat containing E3 ubiquitin protein ligase 1 Homo sapiens 65-70 27956797-13 2016 We also showed that subjects with CD seem to have a lowered production of IL8 in response to MDP in the presence of LB. lb 116-118 C-X-C motif chemokine ligand 8 Homo sapiens 74-77 27194917-5 2016 One hypothesis on LB formation is based on findings that laforin-malin complex downregulates glycogen synthase (GS) through malin-mediated ubiquitination, and the other one is based on findings that laforin dephosphorylates glycogen. lb 18-20 NHL repeat containing E3 ubiquitin protein ligase 1 Homo sapiens 124-129 26907692-4 2016 AT2 from HPS patients and mouse models of HPS exhibit enlarged LB with increased phospholipid content, but the mechanism underlying these defects is unknown. lb 63-65 angiotensin II receptor type 2 Homo sapiens 0-3 26907692-9 2016 Furthermore, AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo Our data provide the first evidence for an AP-3-dependent cargo protein required for the maturation of LB in AT2 and suggest that the loss of PRDX6 activity contributes to the pathogenic changes in LB phospholipid homeostasis found HPS2 patients. lb 28-30 scavenger receptor class B member 2 Homo sapiens 95-101 26907692-9 2016 Furthermore, AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo Our data provide the first evidence for an AP-3-dependent cargo protein required for the maturation of LB in AT2 and suggest that the loss of PRDX6 activity contributes to the pathogenic changes in LB phospholipid homeostasis found HPS2 patients. lb 28-30 scavenger receptor class B member 2 Homo sapiens 102-108 26907692-9 2016 Furthermore, AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo Our data provide the first evidence for an AP-3-dependent cargo protein required for the maturation of LB in AT2 and suggest that the loss of PRDX6 activity contributes to the pathogenic changes in LB phospholipid homeostasis found HPS2 patients. lb 28-30 peroxiredoxin 6 Homo sapiens 113-118 26907692-9 2016 Furthermore, AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo Our data provide the first evidence for an AP-3-dependent cargo protein required for the maturation of LB in AT2 and suggest that the loss of PRDX6 activity contributes to the pathogenic changes in LB phospholipid homeostasis found HPS2 patients. lb 28-30 angiotensin II receptor type 2 Homo sapiens 249-252 26907692-9 2016 Furthermore, AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo Our data provide the first evidence for an AP-3-dependent cargo protein required for the maturation of LB in AT2 and suggest that the loss of PRDX6 activity contributes to the pathogenic changes in LB phospholipid homeostasis found HPS2 patients. lb 28-30 peroxiredoxin 6 Homo sapiens 282-287 26907692-9 2016 Furthermore, AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo Our data provide the first evidence for an AP-3-dependent cargo protein required for the maturation of LB in AT2 and suggest that the loss of PRDX6 activity contributes to the pathogenic changes in LB phospholipid homeostasis found HPS2 patients. lb 28-30 adaptor related protein complex 3 subunit beta 1 Homo sapiens 372-376 26260450-4 2016 Time course analysis of cultured cells transfected with flag-alpha-synuclein and synphilin-1 revealed upregulation of these upstream proteins with accumulation of LB-like inclusions. lb 163-165 synuclein alpha Homo sapiens 61-76 26260450-4 2016 Time course analysis of cultured cells transfected with flag-alpha-synuclein and synphilin-1 revealed upregulation of these upstream proteins with accumulation of LB-like inclusions. lb 163-165 synuclein alpha interacting protein Homo sapiens 81-92