PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29307530-5	2018	Under the optimum conditions, a linear response was achieved for malathion and chlorpyrifos in the concentration range of 0.05 mg L-1-5 mg L-1.	Chlorpyrifos	79-91	immunoglobulin kappa variable 1-16	Homo sapiens	130-133
29307530-5	2018	Under the optimum conditions, a linear response was achieved for malathion and chlorpyrifos in the concentration range of 0.05 mg L-1-5 mg L-1.	Chlorpyrifos	79-91	immunoglobulin kappa variable 1-16	Homo sapiens	139-142
29141517-10	2018	A comparison with the control group demonstrated that CPF administration increased malondialdehyde (MDA) levels in blood, brain and liver, while it reduced catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) concentrations ( p < 0.05-0.001).	Chlorpyrifos	54-57	catalase	Rattus norvegicus	156-164
29141517-10	2018	A comparison with the control group demonstrated that CPF administration increased malondialdehyde (MDA) levels in blood, brain and liver, while it reduced catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) concentrations ( p < 0.05-0.001).	Chlorpyrifos	54-57	catalase	Rattus norvegicus	166-169
29463407-0	2018	Effect of genetic polymorphism of human CYP2B6 on the metabolic activation of chlorpyrifos.	Chlorpyrifos	78-90	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	40-46
29109040-6	2018	Chlorpyrifos exposure significantly reduced serum insulin, C-peptide, and amylin concentrations in NF- and HF-fed rats, leaving serum glucose and lipid profiles unaffected.	Chlorpyrifos	0-12	insulin 2	Rattus norvegicus	59-68
29109040-6	2018	Chlorpyrifos exposure significantly reduced serum insulin, C-peptide, and amylin concentrations in NF- and HF-fed rats, leaving serum glucose and lipid profiles unaffected.	Chlorpyrifos	0-12	islet amyloid polypeptide	Rattus norvegicus	74-80
29463407-2	2018	Chlorpyrifos oxon (CPO) is a toxic metabolite of CPS that is produced by CYP2B6.	Chlorpyrifos	49-52	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	73-79
29463407-3	2018	In this study, we examined the variability of CPS metabolism resulting from single-nucleotide polymorphisms in CYP2B6.	Chlorpyrifos	46-49	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	111-117
29463407-6	2018	The conversion of CPS to CPO by the CYP2B6 variants was analyzed with high-performance liquid chromatography.	Chlorpyrifos	18-21	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-42
29463407-9	2018	These results indicate that the amino acid substitutions in the CYP2B6 variants suppressed the metabolic activation of CPS.	Chlorpyrifos	119-122	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	64-70
28721614-11	2017	The ALT, AST, GGT, and creatinine contents were significantly increased (p < 0.05 and p < 0.01, respectively) on CPF exposure.	Chlorpyrifos	119-122	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	9-12
29594500-8	2017	The method allows the concentrations of chlorpyrifos to be quantified down to 4.9 ng mL-1, which is equivalent to 61 mug kg-1 in dried tangerine peels.	Chlorpyrifos	40-52	L1 cell adhesion molecule	Mus musculus	85-89
29251619-10	2017	The results showed that rats from the group consuming food after enzymatic removal of chlorpyrifos, had comparable acetyl cholinesterase activity in blood of rats consuming pure food (without any OP intoxication).	Chlorpyrifos	86-98	butyrylcholinesterase	Rattus norvegicus	122-136
28721614-11	2017	The ALT, AST, GGT, and creatinine contents were significantly increased (p < 0.05 and p < 0.01, respectively) on CPF exposure.	Chlorpyrifos	119-122	gamma-glutamyltransferase 1	Rattus norvegicus	14-17
28820005-1	2017	Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity.	Chlorpyrifos	72-84	fatty-acid amide hydrolase-like	Rattus norvegicus	134-138
28820005-1	2017	Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity.	Chlorpyrifos	72-84	monoglyceride lipase	Rattus norvegicus	208-231
28820005-1	2017	Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity.	Chlorpyrifos	72-84	monoglyceride lipase	Rattus norvegicus	233-237
28820005-1	2017	Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity.	Chlorpyrifos	86-89	fatty-acid amide hydrolase-like	Rattus norvegicus	134-138
28820005-1	2017	Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity.	Chlorpyrifos	86-89	monoglyceride lipase	Rattus norvegicus	208-231
28820005-1	2017	Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity.	Chlorpyrifos	86-89	monoglyceride lipase	Rattus norvegicus	233-237
28467056-9	2017	The detection limits for diazinon(oxon) and chlorpyrifos(oxon) were estimated to be as low as 6 x 10-12 M and 8 x 10-12 M, respectively, after 20 min of preincubation with these irreversible inhibitors of BChE.	Chlorpyrifos	44-56	butyrylcholinesterase	Homo sapiens	205-209
28137318-2	2017	The chlorpyrifos resistance of these strains was mediated by a modified acetylcholinesterase encoded by an allele, ace1R, of the ace1 gene.	Chlorpyrifos	4-16	acetylcholinesterase-like	Plutella xylostella	115-119
28402838-9	2017	Exposure to neurotoxic chlorpyrifos, malathion and cypermethrin resulted in up-regulation of nAChRalpha1 and nAChRalpha2.	Chlorpyrifos	23-35	nicotinic acetylcholine receptor alpha1 subunit	Apis mellifera	93-104
28402838-9	2017	Exposure to neurotoxic chlorpyrifos, malathion and cypermethrin resulted in up-regulation of nAChRalpha1 and nAChRalpha2.	Chlorpyrifos	23-35	nicotinic acetylcholine receptor alpha2 subunit	Apis mellifera	109-120
28600141-2	2017	While the insecticidal actions and acute toxicity of CPF are attributed to its oxon metabolite (CPO) which potently inhibits the cholinergic enzyme acetylcholinesterase (AChE), there is significant evidence that CPF, CPO, and other organophosphates may affect a variety of neuronal targets and processes that are not directly related to AChE.	Chlorpyrifos	53-56	acetylcholinesterase	Rattus norvegicus	148-168
28600141-2	2017	While the insecticidal actions and acute toxicity of CPF are attributed to its oxon metabolite (CPO) which potently inhibits the cholinergic enzyme acetylcholinesterase (AChE), there is significant evidence that CPF, CPO, and other organophosphates may affect a variety of neuronal targets and processes that are not directly related to AChE.	Chlorpyrifos	53-56	acetylcholinesterase	Rattus norvegicus	170-174
28600141-2	2017	While the insecticidal actions and acute toxicity of CPF are attributed to its oxon metabolite (CPO) which potently inhibits the cholinergic enzyme acetylcholinesterase (AChE), there is significant evidence that CPF, CPO, and other organophosphates may affect a variety of neuronal targets and processes that are not directly related to AChE.	Chlorpyrifos	53-56	acetylcholinesterase	Rattus norvegicus	337-341
28296077-7	2017	We found that the combination of CPF and high dose of CdCl2 had a synergistic inhibitory effect on production of IFN-gamma by spleen cells induced by Con A.	Chlorpyrifos	33-36	interferon gamma	Rattus norvegicus	113-122
28467056-8	2017	The SPE-MnO2/MG/BChE biosensor enabled precision detection of organophosphorus pesticides (diazinon(oxon), chlorpyrifos(oxon)) in aqueous samples with minimized interference from extraneous (nonanalyte) substances (e.g., ions of heavy metals).	Chlorpyrifos	107-119	butyrylcholinesterase	Homo sapiens	16-20
28595929-0	2017	Solvent-dependent binding interactions of the organophosphate pesticide, chlorpyrifos (CPF), and its metabolite, 3,5,6-trichloro-2-pyridinol (TCPy), with Bovine Serum Albumin (BSA): A comparative fluorescence quenching analysis.	Chlorpyrifos	73-85	albumin	Homo sapiens	161-174
28369648-3	2017	Cytochrome P450 enzymes are expressed at a relatively high level in astrocytes and may play a critical role in the biotransformation of endogenous or exogenous compounds, including chlorpyrifos, an organophosphate insecticide that affects the central nervous system.	Chlorpyrifos	181-193	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
28369648-4	2017	P450 enzymes metabolize chlorpyrifos to chlorpyrifos-oxon, which is then metabolized primarily to 3, 5, 6-trichloropyridinol in addition to diethylphosphate and diethylthiophosphate.	Chlorpyrifos	24-36	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4
28369648-7	2017	In neuron-only cultures, chlorpyrifos inhibited neurite length, neurite number and branch points per neuron in a dose-dependent manner during a 48 h exposure, starting at 10 muM.	Chlorpyrifos	25-37	latexin	Homo sapiens	174-177
28369648-8	2017	However, in astrocyte-neuron cocultures, astrocytes protected neurons from the effects of chlorpyrifos at higher concentrations, up to and including 30 muM chlorpyrifos and endogenous astrocyte P450 enzymes effectively metabolized chlorpyrifos.	Chlorpyrifos	156-168	latexin	Homo sapiens	152-155
28369648-8	2017	However, in astrocyte-neuron cocultures, astrocytes protected neurons from the effects of chlorpyrifos at higher concentrations, up to and including 30 muM chlorpyrifos and endogenous astrocyte P450 enzymes effectively metabolized chlorpyrifos.	Chlorpyrifos	156-168	latexin	Homo sapiens	152-155
28369648-9	2017	The P450 inhibitor SKF525A partly negated the protective effect of astrocytes, allowing reduction in branch points with chlorpyrifos (10 muM).	Chlorpyrifos	120-132	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	4-8
28369648-9	2017	The P450 inhibitor SKF525A partly negated the protective effect of astrocytes, allowing reduction in branch points with chlorpyrifos (10 muM).	Chlorpyrifos	120-132	latexin	Homo sapiens	137-140
28369648-10	2017	Thus, the scalable and defined astrocyte-neuron cocultures model that we established here has potentially identified a role for P450 enzymes in astrocytic neuroprotection against chlorpyrifos and provides a novel model for addressing DNT in a more accurate multicellular environment.	Chlorpyrifos	179-191	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	128-132
28595929-0	2017	Solvent-dependent binding interactions of the organophosphate pesticide, chlorpyrifos (CPF), and its metabolite, 3,5,6-trichloro-2-pyridinol (TCPy), with Bovine Serum Albumin (BSA): A comparative fluorescence quenching analysis.	Chlorpyrifos	87-90	albumin	Homo sapiens	161-174
28595929-2	2017	In this study, we have investigated the binding interaction of Bovine Serum Albumin (BSA) with a widely used organophosphorous insecticide chlorpyrifos (CPF), and its stable metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) to provide a comparative analysis of the two molecules by employing various spectroscopic techniques viz., UV-vis absorption, Circular Dichroism (CD), and Fluorescence spectroscopy.	Chlorpyrifos	139-151	albumin	Homo sapiens	70-83
28595929-2	2017	In this study, we have investigated the binding interaction of Bovine Serum Albumin (BSA) with a widely used organophosphorous insecticide chlorpyrifos (CPF), and its stable metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) to provide a comparative analysis of the two molecules by employing various spectroscopic techniques viz., UV-vis absorption, Circular Dichroism (CD), and Fluorescence spectroscopy.	Chlorpyrifos	153-156	albumin	Homo sapiens	70-83
28558014-0	2017	Correction: Retinoic acid exacerbates chlorpyrifos action in ensuing adipogenic differentiation of C3H10T1/2 cells in a GSK3beta dependent pathway.	Chlorpyrifos	38-50	glycogen synthase kinase 3 beta	Mus musculus	120-128
28373059-6	2017	Also, 6-GRF improved the activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary and uterus of rats exposed to CPF (p < 0.05).	Chlorpyrifos	248-251	hematopoietic prostaglandin D synthase	Rattus norvegicus	158-161
27268782-4	2017	Also, CPF and CBZ co-exposure significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine ( p < 0.05) when compared with the groups treated with CBZ or CPF alone and the control.	Chlorpyrifos	6-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	68-94
27268782-4	2017	Also, CPF and CBZ co-exposure significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine ( p < 0.05) when compared with the groups treated with CBZ or CPF alone and the control.	Chlorpyrifos	6-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	96-99
28300621-1	2017	We hypothesized that expression of mutant Huntingtin (HTT) would modulate the neurotoxicity of the commonly used organophosphate insecticide, chlorpyrifos (CPF), revealing cellular mechanisms underlying neurodegeneration.	Chlorpyrifos	142-154	huntingtin	Mus musculus	42-52
28300621-1	2017	We hypothesized that expression of mutant Huntingtin (HTT) would modulate the neurotoxicity of the commonly used organophosphate insecticide, chlorpyrifos (CPF), revealing cellular mechanisms underlying neurodegeneration.	Chlorpyrifos	142-154	huntingtin	Mus musculus	54-57
28300621-1	2017	We hypothesized that expression of mutant Huntingtin (HTT) would modulate the neurotoxicity of the commonly used organophosphate insecticide, chlorpyrifos (CPF), revealing cellular mechanisms underlying neurodegeneration.	Chlorpyrifos	156-159	huntingtin	Mus musculus	42-52
28300621-1	2017	We hypothesized that expression of mutant Huntingtin (HTT) would modulate the neurotoxicity of the commonly used organophosphate insecticide, chlorpyrifos (CPF), revealing cellular mechanisms underlying neurodegeneration.	Chlorpyrifos	156-159	huntingtin	Mus musculus	54-57
27951421-4	2017	The results showed that wheat exposed to higher concentrations of chlorpyrifos (>=20mgkg-1) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX).	Chlorpyrifos	66-78	catalase-1	Triticum aestivum	245-253
26892626-0	2017	Clearance of Damaged Mitochondria Through PINK1 Stabilization by JNK and ERK MAPK Signaling in Chlorpyrifos-Treated Neuroblastoma Cells.	Chlorpyrifos	95-107	PTEN induced kinase 1	Homo sapiens	42-47
28291828-0	2017	Retinoic acid exacerbates chlorpyrifos action in ensuing adipogenic differentiation of C3H10T1/2 cells in a GSK3beta dependent pathway.	Chlorpyrifos	26-38	glycogen synthase kinase 3 beta	Mus musculus	108-116
27951421-4	2017	The results showed that wheat exposed to higher concentrations of chlorpyrifos (>=20mgkg-1) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX).	Chlorpyrifos	66-78	catalase-1	Triticum aestivum	255-258
27951421-4	2017	The results showed that wheat exposed to higher concentrations of chlorpyrifos (>=20mgkg-1) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX).	Chlorpyrifos	66-78	peroxidase-like	Triticum aestivum	261-271
26892626-0	2017	Clearance of Damaged Mitochondria Through PINK1 Stabilization by JNK and ERK MAPK Signaling in Chlorpyrifos-Treated Neuroblastoma Cells.	Chlorpyrifos	95-107	mitogen-activated protein kinase 1	Homo sapiens	73-76
26892626-0	2017	Clearance of Damaged Mitochondria Through PINK1 Stabilization by JNK and ERK MAPK Signaling in Chlorpyrifos-Treated Neuroblastoma Cells.	Chlorpyrifos	95-107	mitogen-activated protein kinase 3	Homo sapiens	77-81
26892626-12	2017	The simple interpretation of these results is that JNK and ERK1/2 signaling regulates PINK1/Parkin-dependent mitophagy in the mitochondria of CPF-treated cells.	Chlorpyrifos	142-145	mitogen-activated protein kinase 8	Homo sapiens	51-54
26892626-12	2017	The simple interpretation of these results is that JNK and ERK1/2 signaling regulates PINK1/Parkin-dependent mitophagy in the mitochondria of CPF-treated cells.	Chlorpyrifos	142-145	mitogen-activated protein kinase 3	Homo sapiens	59-65
27951421-4	2017	The results showed that wheat exposed to higher concentrations of chlorpyrifos (>=20mgkg-1) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX).	Chlorpyrifos	66-78	peroxidase-like	Triticum aestivum	273-276
26892626-12	2017	The simple interpretation of these results is that JNK and ERK1/2 signaling regulates PINK1/Parkin-dependent mitophagy in the mitochondria of CPF-treated cells.	Chlorpyrifos	142-145	PTEN induced kinase 1	Homo sapiens	86-91
27951421-4	2017	The results showed that wheat exposed to higher concentrations of chlorpyrifos (>=20mgkg-1) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX).	Chlorpyrifos	66-78	POD1	Triticum aestivum	283-303
27951421-4	2017	The results showed that wheat exposed to higher concentrations of chlorpyrifos (>=20mgkg-1) caused declines in growth and chlorophyll content and altered the activities of a series of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX).	Chlorpyrifos	66-78	POD1	Triticum aestivum	305-308
26948828-2	2017	PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs) such as methyl parathion and chlorpyrifos.	Chlorpyrifos	119-131	paraoxonase 1	Homo sapiens	0-4
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	12-24	fatty-acid amide hydrolase-like	Rattus norvegicus	124-144
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	12-24	fatty-acid amide hydrolase-like	Rattus norvegicus	146-150
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	12-24	monoglyceride lipase	Rattus norvegicus	156-179
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	12-24	monoglyceride lipase	Rattus norvegicus	181-185
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	26-29	fatty-acid amide hydrolase-like	Rattus norvegicus	124-144
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	26-29	fatty-acid amide hydrolase-like	Rattus norvegicus	146-150
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	26-29	monoglyceride lipase	Rattus norvegicus	156-179
26642910-1	2017	Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG).	Chlorpyrifos	26-29	monoglyceride lipase	Rattus norvegicus	181-185
27722883-0	2017	Chlorpyrifos pollution: its effect on brain acetylcholinesterase activity in rat and treatment of polluted soil by indigenous Pseudomonas sp.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	44-64
27722883-1	2017	The study was aimed to evaluate the levels of chlorpyrifos (CPF) pollution in agricultural soil of Punjab, India, its detrimental effects on acetylcholinesterase (AChE) activity in rat brain and bioremediation of soils polluted with CPF using indigenous and adapted bacterial lab isolate.	Chlorpyrifos	46-58	acetylcholinesterase	Rattus norvegicus	141-161
27722883-1	2017	The study was aimed to evaluate the levels of chlorpyrifos (CPF) pollution in agricultural soil of Punjab, India, its detrimental effects on acetylcholinesterase (AChE) activity in rat brain and bioremediation of soils polluted with CPF using indigenous and adapted bacterial lab isolate.	Chlorpyrifos	46-58	acetylcholinesterase	Rattus norvegicus	163-167
27614262-4	2016	However, degradation rate in soil-water based slurry system was slow as it took 10 days to degrade 82% of added chlorpyrifos (50mg/kg) by a potential mixed culture CS2 comprised of isolates F-3 and CH-y.	Chlorpyrifos	112-124	chorionic somatomammotropin hormone 2	Homo sapiens	164-167
27545116-0	2017	Impact of prenatal and postnatal exposure to the pesticide chlorpyrifos on the contraction of rat ileal muscle strips: involvement of an inducible nitric oxide synthase-dependent pathway.	Chlorpyrifos	59-71	nitric oxide synthase 2	Rattus norvegicus	137-168
27545116-2	2017	Chlorpyrifos (CPF) is a widely used organophosphorus acetylcholinesterase (AChE)-inhibiting insecticide.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	53-73
27545116-2	2017	Chlorpyrifos (CPF) is a widely used organophosphorus acetylcholinesterase (AChE)-inhibiting insecticide.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	75-79
27545116-2	2017	Chlorpyrifos (CPF) is a widely used organophosphorus acetylcholinesterase (AChE)-inhibiting insecticide.	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	53-73
27545116-2	2017	Chlorpyrifos (CPF) is a widely used organophosphorus acetylcholinesterase (AChE)-inhibiting insecticide.	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	75-79
28112198-0	2017	Chlorpyrifos inhibits neural induction via Mfn1-mediated mitochondrial dysfunction in human induced pluripotent stem cells.	Chlorpyrifos	0-12	mitofusin 1	Homo sapiens	43-47
27681257-5	2017	MSPE was linear in the range 100-1000 pg mL-1 for phosphamidon and dimethoate, and 10-100 pg mL-1 for chlorpyrifos and diazinon, with limit of detection (S/N = 3) of 19.8, 23.7, 1.4 and 2.9 pg mL-1 for phosphamidon, dimethoate, diazinon and chlorpyrifos, respectively.	Chlorpyrifos	102-114	L1 cell adhesion molecule	Mus musculus	93-97
27681257-5	2017	MSPE was linear in the range 100-1000 pg mL-1 for phosphamidon and dimethoate, and 10-100 pg mL-1 for chlorpyrifos and diazinon, with limit of detection (S/N = 3) of 19.8, 23.7, 1.4 and 2.9 pg mL-1 for phosphamidon, dimethoate, diazinon and chlorpyrifos, respectively.	Chlorpyrifos	102-114	L1 cell adhesion molecule	Mus musculus	93-97
27318105-3	2016	Three zein-based devices are proposed for several applications: (1) inorganic phosphorus estimation in water of different sources (river, lake, coastal water and tap water) with a detection limit of 0.2mg/L - compared to at least 1mg/L required by legislation, (2) estimation of ALP in saliva and (3) chlorpyrifos control in commercial preparations.	Chlorpyrifos	301-313	zein	Zea mays	6-10
26948828-5	2017	In this study, we evaluated the effects of methyl parathion and chlorpyrifos on the modulation of PON1 in Human Hepatocellular Carcinoma (HepG2) cells by real-time PCR, PON1 activity assay, and western blot.	Chlorpyrifos	64-76	paraoxonase 1	Homo sapiens	98-102
26948828-6	2017	The results showed that the treatments with methyl parathion and chlorpyrifos decreased PON1 mRNA and immunoreactive protein and increased inflammatory cytokines in HepG2 cells.	Chlorpyrifos	65-77	paraoxonase 1	Homo sapiens	88-92
26948828-7	2017	The effects of methyl parathion and chlorpyrifos on the downregulation of PON1 gene expression in HepG2 cells may provide evidence of OPs cytotoxicity related to oxidative stress and an inflammatory response.	Chlorpyrifos	36-48	paraoxonase 1	Homo sapiens	74-78
27720795-5	2016	Chronic 14-day exposure to methylmercury, chlorpyrifos and alpha-cypermethrin inhibited MSR, all with a lowest-observed effect concentration (LOEC) of 0.1muM, while exposure to endosulfan increased MSR [LOEC: 1muM].	Chlorpyrifos	42-54	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	88-91
27720795-5	2016	Chronic 14-day exposure to methylmercury, chlorpyrifos and alpha-cypermethrin inhibited MSR, all with a lowest-observed effect concentration (LOEC) of 0.1muM, while exposure to endosulfan increased MSR [LOEC: 1muM].	Chlorpyrifos	42-54	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	198-201
27720795-7	2016	Similar to the observations in the chronic 14-day exposure studies, MSR was inhibited by acute 30-min exposure to methylmercury, chlorpyrifos, and alpha-cypermethrin [LOECs: 1muM, 10muM, and 1muM, respectively], whereas endosulfan increased MSR [LOEC: 0.3muM].	Chlorpyrifos	129-141	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	68-71
27117976-1	2016	Chlorpyrifos (CPS) is an organophosphorus compound (OP) capable of causing well-known cholinergic and delayed syndromes through the inhibition of acetylcholinesterase and Neuropathy Target Esterase (NTE), respectively.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	146-166
27117976-1	2016	Chlorpyrifos (CPS) is an organophosphorus compound (OP) capable of causing well-known cholinergic and delayed syndromes through the inhibition of acetylcholinesterase and Neuropathy Target Esterase (NTE), respectively.	Chlorpyrifos	0-12	patatin-like phospholipase domain containing 6	Mus musculus	171-197
27117976-1	2016	Chlorpyrifos (CPS) is an organophosphorus compound (OP) capable of causing well-known cholinergic and delayed syndromes through the inhibition of acetylcholinesterase and Neuropathy Target Esterase (NTE), respectively.	Chlorpyrifos	0-12	patatin-like phospholipase domain containing 6	Mus musculus	199-202
27521977-0	2016	Chlorpyrifos- and chlorpyrifos oxon-induced neurite retraction in pre-differentiated N2a cells is associated with transient hyperphosphorylation of neurofilament heavy chain and ERK 1/2.	Chlorpyrifos	0-12	neurofilament, heavy polypeptide	Mus musculus	148-173
27669663-0	2016	Chlorpyrifos exposure affects fgf8, sox9, and bmp4 expression required for cranial neural crest morphogenesis and chondrogenesis in Xenopus laevis embryos.	Chlorpyrifos	0-12	fibroblast growth factor 8 S homeolog	Xenopus laevis	30-34
27669663-0	2016	Chlorpyrifos exposure affects fgf8, sox9, and bmp4 expression required for cranial neural crest morphogenesis and chondrogenesis in Xenopus laevis embryos.	Chlorpyrifos	0-12	SRY-box 9 L homeolog	Xenopus laevis	36-40
27669663-0	2016	Chlorpyrifos exposure affects fgf8, sox9, and bmp4 expression required for cranial neural crest morphogenesis and chondrogenesis in Xenopus laevis embryos.	Chlorpyrifos	0-12	bone morphogenetic protein 4 L homeolog	Xenopus laevis	46-50
27521977-0	2016	Chlorpyrifos- and chlorpyrifos oxon-induced neurite retraction in pre-differentiated N2a cells is associated with transient hyperphosphorylation of neurofilament heavy chain and ERK 1/2.	Chlorpyrifos	0-12	mitogen-activated protein kinase 3	Mus musculus	178-185
27626050-0	2016	Data on the phosphorylation of p38MAPK and JNK induced by chlorpyrifos in Drosophila melanogaster.	Chlorpyrifos	58-70	p38b MAP kinase	Drosophila melanogaster	31-38
27626050-0	2016	Data on the phosphorylation of p38MAPK and JNK induced by chlorpyrifos in Drosophila melanogaster.	Chlorpyrifos	58-70	basket	Drosophila melanogaster	43-46
27626050-4	2016	Here we report data on the phosphorylation of p38MAPK and JNK, members of the MAPK family, in Drosophila melanogaster exposed to chlorpyrifos, as characterized by western blotting assays.	Chlorpyrifos	129-141	p38b MAP kinase	Drosophila melanogaster	46-53
27626050-4	2016	Here we report data on the phosphorylation of p38MAPK and JNK, members of the MAPK family, in Drosophila melanogaster exposed to chlorpyrifos, as characterized by western blotting assays.	Chlorpyrifos	129-141	basket	Drosophila melanogaster	58-61
27163631-0	2016	SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and alpha7-nAChRs alterations mediated partially by AChE variants disruption.	Chlorpyrifos	73-85	nerve growth factor receptor	Rattus norvegicus	132-135
29709151-1	2016	Excessive microglial activation and subsequent neuroinflammation lead to neuronal cell death,which are involved in the pathogenesis and progression of several neurodegenerative diseases such as Parkinson"s disease.The objective of this study was to determine the involvement of chlorpyrifos(CPF)in the activation of microglia and production of inflammatory factors in response to CPF stimulation and the influence on the viability of dopaminergic(DA)neurons.We detected the change of BV-2cells morphology and expression of inducible nitric oxide(iNOS),cyclooxygenase-2(COX-2)mRNA and protein level upon CPF stimulation(0,1,3,6,12,24h)in BV-2(mouse brain microglia)cells by reverse transcription polymerase chain reaction(RT-PCR)or Western blot.We randomly assigned BV-2cells into CPF,menstruum dimethysulfoxide(DMSO)and normal saline(NS)groups.We stimulated The BV-2cells in the CPF group with CPF,and we stimulated the two control groups with DMSO or NS for 12 hours,respectively.We then collected the used culture media from the culture dishes and centrifuged it to remove the detached cells.Then,we used the supernatants as microglial conditioned media.We treated SH-SY5 Yneurons with various groups of microglial conditioned media for 24 hours.We observed the effect of conditioned media collected from BV-2cell on the viability of dopaminergic cell lines SH-SY5 Yusing MTT assay.We found that inflammatory factors iNOS,COX-2mRNA and protein levels were up-regulated upon CPF stimulation.Conditioned media from BV-2upon CPF stimulation is toxic to SH-SY5 Y.It might be concluded that the exposure to CPF may induce dopaminergic neuronal damage by the activation of inflammatory response,and a mechanism may be involved in Parkinson"s disease pathogenesis.	Chlorpyrifos	278-290	nitric oxide synthase 2, inducible	Mus musculus	546-550
29709151-1	2016	Excessive microglial activation and subsequent neuroinflammation lead to neuronal cell death,which are involved in the pathogenesis and progression of several neurodegenerative diseases such as Parkinson"s disease.The objective of this study was to determine the involvement of chlorpyrifos(CPF)in the activation of microglia and production of inflammatory factors in response to CPF stimulation and the influence on the viability of dopaminergic(DA)neurons.We detected the change of BV-2cells morphology and expression of inducible nitric oxide(iNOS),cyclooxygenase-2(COX-2)mRNA and protein level upon CPF stimulation(0,1,3,6,12,24h)in BV-2(mouse brain microglia)cells by reverse transcription polymerase chain reaction(RT-PCR)or Western blot.We randomly assigned BV-2cells into CPF,menstruum dimethysulfoxide(DMSO)and normal saline(NS)groups.We stimulated The BV-2cells in the CPF group with CPF,and we stimulated the two control groups with DMSO or NS for 12 hours,respectively.We then collected the used culture media from the culture dishes and centrifuged it to remove the detached cells.Then,we used the supernatants as microglial conditioned media.We treated SH-SY5 Yneurons with various groups of microglial conditioned media for 24 hours.We observed the effect of conditioned media collected from BV-2cell on the viability of dopaminergic cell lines SH-SY5 Yusing MTT assay.We found that inflammatory factors iNOS,COX-2mRNA and protein levels were up-regulated upon CPF stimulation.Conditioned media from BV-2upon CPF stimulation is toxic to SH-SY5 Y.It might be concluded that the exposure to CPF may induce dopaminergic neuronal damage by the activation of inflammatory response,and a mechanism may be involved in Parkinson"s disease pathogenesis.	Chlorpyrifos	278-290	prostaglandin-endoperoxide synthase 2	Mus musculus	552-568
29709151-1	2016	Excessive microglial activation and subsequent neuroinflammation lead to neuronal cell death,which are involved in the pathogenesis and progression of several neurodegenerative diseases such as Parkinson"s disease.The objective of this study was to determine the involvement of chlorpyrifos(CPF)in the activation of microglia and production of inflammatory factors in response to CPF stimulation and the influence on the viability of dopaminergic(DA)neurons.We detected the change of BV-2cells morphology and expression of inducible nitric oxide(iNOS),cyclooxygenase-2(COX-2)mRNA and protein level upon CPF stimulation(0,1,3,6,12,24h)in BV-2(mouse brain microglia)cells by reverse transcription polymerase chain reaction(RT-PCR)or Western blot.We randomly assigned BV-2cells into CPF,menstruum dimethysulfoxide(DMSO)and normal saline(NS)groups.We stimulated The BV-2cells in the CPF group with CPF,and we stimulated the two control groups with DMSO or NS for 12 hours,respectively.We then collected the used culture media from the culture dishes and centrifuged it to remove the detached cells.Then,we used the supernatants as microglial conditioned media.We treated SH-SY5 Yneurons with various groups of microglial conditioned media for 24 hours.We observed the effect of conditioned media collected from BV-2cell on the viability of dopaminergic cell lines SH-SY5 Yusing MTT assay.We found that inflammatory factors iNOS,COX-2mRNA and protein levels were up-regulated upon CPF stimulation.Conditioned media from BV-2upon CPF stimulation is toxic to SH-SY5 Y.It might be concluded that the exposure to CPF may induce dopaminergic neuronal damage by the activation of inflammatory response,and a mechanism may be involved in Parkinson"s disease pathogenesis.	Chlorpyrifos	278-290	cytochrome c oxidase II, mitochondrial	Mus musculus	569-574
29709151-1	2016	Excessive microglial activation and subsequent neuroinflammation lead to neuronal cell death,which are involved in the pathogenesis and progression of several neurodegenerative diseases such as Parkinson"s disease.The objective of this study was to determine the involvement of chlorpyrifos(CPF)in the activation of microglia and production of inflammatory factors in response to CPF stimulation and the influence on the viability of dopaminergic(DA)neurons.We detected the change of BV-2cells morphology and expression of inducible nitric oxide(iNOS),cyclooxygenase-2(COX-2)mRNA and protein level upon CPF stimulation(0,1,3,6,12,24h)in BV-2(mouse brain microglia)cells by reverse transcription polymerase chain reaction(RT-PCR)or Western blot.We randomly assigned BV-2cells into CPF,menstruum dimethysulfoxide(DMSO)and normal saline(NS)groups.We stimulated The BV-2cells in the CPF group with CPF,and we stimulated the two control groups with DMSO or NS for 12 hours,respectively.We then collected the used culture media from the culture dishes and centrifuged it to remove the detached cells.Then,we used the supernatants as microglial conditioned media.We treated SH-SY5 Yneurons with various groups of microglial conditioned media for 24 hours.We observed the effect of conditioned media collected from BV-2cell on the viability of dopaminergic cell lines SH-SY5 Yusing MTT assay.We found that inflammatory factors iNOS,COX-2mRNA and protein levels were up-regulated upon CPF stimulation.Conditioned media from BV-2upon CPF stimulation is toxic to SH-SY5 Y.It might be concluded that the exposure to CPF may induce dopaminergic neuronal damage by the activation of inflammatory response,and a mechanism may be involved in Parkinson"s disease pathogenesis.	Chlorpyrifos	278-290	nitric oxide synthase 2, inducible	Mus musculus	1419-1423
29709151-1	2016	Excessive microglial activation and subsequent neuroinflammation lead to neuronal cell death,which are involved in the pathogenesis and progression of several neurodegenerative diseases such as Parkinson"s disease.The objective of this study was to determine the involvement of chlorpyrifos(CPF)in the activation of microglia and production of inflammatory factors in response to CPF stimulation and the influence on the viability of dopaminergic(DA)neurons.We detected the change of BV-2cells morphology and expression of inducible nitric oxide(iNOS),cyclooxygenase-2(COX-2)mRNA and protein level upon CPF stimulation(0,1,3,6,12,24h)in BV-2(mouse brain microglia)cells by reverse transcription polymerase chain reaction(RT-PCR)or Western blot.We randomly assigned BV-2cells into CPF,menstruum dimethysulfoxide(DMSO)and normal saline(NS)groups.We stimulated The BV-2cells in the CPF group with CPF,and we stimulated the two control groups with DMSO or NS for 12 hours,respectively.We then collected the used culture media from the culture dishes and centrifuged it to remove the detached cells.Then,we used the supernatants as microglial conditioned media.We treated SH-SY5 Yneurons with various groups of microglial conditioned media for 24 hours.We observed the effect of conditioned media collected from BV-2cell on the viability of dopaminergic cell lines SH-SY5 Yusing MTT assay.We found that inflammatory factors iNOS,COX-2mRNA and protein levels were up-regulated upon CPF stimulation.Conditioned media from BV-2upon CPF stimulation is toxic to SH-SY5 Y.It might be concluded that the exposure to CPF may induce dopaminergic neuronal damage by the activation of inflammatory response,and a mechanism may be involved in Parkinson"s disease pathogenesis.	Chlorpyrifos	278-290	cytochrome c oxidase II, mitochondrial	Mus musculus	1424-1429
27163631-0	2016	SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and alpha7-nAChRs alterations mediated partially by AChE variants disruption.	Chlorpyrifos	73-85	nerve growth factor receptor	Rattus norvegicus	136-139
27163631-0	2016	SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure through oxidative stress generation; P75(NTR) and alpha7-nAChRs alterations mediated partially by AChE variants disruption.	Chlorpyrifos	73-85	acetylcholinesterase	Rattus norvegicus	193-197
26414738-6	2016	While CbE and BChE activities were inhibited by chlorpyrifos in all tissues during the third and fourth weeks following pesticide treatment, AChE activity was unaffected.	Chlorpyrifos	48-60	cholinesterase	Coturnix japonica	14-18
26414738-10	2016	The inhibition of CbE and BChE activities corroborated that these enzymes are fulfilling their role as bioscavengers for organophosphate pesticides, decreasing its concentration and thus protecting AChE activity against inhibition by chlorpyrifos.	Chlorpyrifos	234-246	cholinesterase	Coturnix japonica	26-30
26518068-2	2016	We have previously demonstrated that the pesticide chlorpyrifos (CPF) acts as an ED in vitro, since it induces human breast cancer cells proliferation through estrogen receptor alpha (ERalpha) pathway.	Chlorpyrifos	51-63	estrogen receptor 1	Homo sapiens	159-182
26519800-4	2016	The average first order photo-degradation rate constants in the absence and presence of 500 mM fructose were 0.92 and 2.07 min(-1) respectively for diuron and 0.04 and 0.07 min(-1) for chlorpyrifos.	Chlorpyrifos	185-197	CD59 molecule (CD59 blood group)	Homo sapiens	173-179
26518068-2	2016	We have previously demonstrated that the pesticide chlorpyrifos (CPF) acts as an ED in vitro, since it induces human breast cancer cells proliferation through estrogen receptor alpha (ERalpha) pathway.	Chlorpyrifos	51-63	estrogen receptor 1	Homo sapiens	184-191
26518068-2	2016	We have previously demonstrated that the pesticide chlorpyrifos (CPF) acts as an ED in vitro, since it induces human breast cancer cells proliferation through estrogen receptor alpha (ERalpha) pathway.	Chlorpyrifos	65-68	estrogen receptor 1	Homo sapiens	159-182
26518068-2	2016	We have previously demonstrated that the pesticide chlorpyrifos (CPF) acts as an ED in vitro, since it induces human breast cancer cells proliferation through estrogen receptor alpha (ERalpha) pathway.	Chlorpyrifos	65-68	estrogen receptor 1	Homo sapiens	184-191
26155973-5	2016	In addition, we apply SMD simulations to identify potential escape routes of chlorpyrifos from hydrolase hydrophobic cavities in the APH-inhibitor complex.	Chlorpyrifos	77-89	acylaminoacyl-peptide hydrolase	Homo sapiens	133-136
26435000-0	2015	Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells.	Chlorpyrifos	0-12	NLR family pyrin domain containing 3	Homo sapiens	21-26
26598294-0	2015	Dynamin-related protein 1 mediates mitochondria-dependent apoptosis in chlorpyrifos-treated SH-SY5Y cells.	Chlorpyrifos	71-83	dynamin 1 like	Homo sapiens	0-25
26514924-0	2015	Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway.	Chlorpyrifos	0-12	epidermal growth factor receptor	Homo sapiens	91-95
26514924-0	2015	Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway.	Chlorpyrifos	0-12	mitogen-activated protein kinase 3	Homo sapiens	96-102
26524701-0	2015	The effect of HMGB1 on sub-toxic chlorpyrifos exposure-induced neuroinflammation in amygdala of neonatal rats.	Chlorpyrifos	33-45	high mobility group box 1	Rattus norvegicus	14-19
26598294-2	2015	However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity.	Chlorpyrifos	94-106	dynamin 1 like	Homo sapiens	54-58
26598294-2	2015	However, little is known about the mechanism by which Drp1 modulates apoptosis in response to chlorpyrifos (CPF)-induced toxicity.	Chlorpyrifos	108-111	dynamin 1 like	Homo sapiens	54-58
26598294-3	2015	In this study, we determined that CPF-induced mitochondrial apoptosis is mediated by Drp1 translocation in SH-SY5Y human neuroblastoma cells.	Chlorpyrifos	34-37	dynamin 1 like	Homo sapiens	85-89
26598294-11	2015	Taken together, these data reveal a novel mechanism by which Drp1 activates mitochondrial-dependent apoptosis and indicate that inhibiting Dpr1 function can protect against CPF-induced cytotoxicity.	Chlorpyrifos	173-176	dynamin 1 like	Homo sapiens	61-65
26598294-11	2015	Taken together, these data reveal a novel mechanism by which Drp1 activates mitochondrial-dependent apoptosis and indicate that inhibiting Dpr1 function can protect against CPF-induced cytotoxicity.	Chlorpyrifos	173-176	dishevelled binding antagonist of beta catenin 1	Homo sapiens	139-143
25897622-5	2015	Pretreatment with function-blocking IL-5 antibody prevented chlorpyrifos-induced airway hyperreactivity in sensitized, but not in nonsensitized, guinea pigs.	Chlorpyrifos	60-72	interleukin-5	Cavia porcellus	36-40
26884967-5	2015	By contrast, paraquat and chlorpyrifos together resulted in robust accumulation of alpha-Syn in striata in mice.	Chlorpyrifos	26-38	synuclein, alpha	Mus musculus	83-92
26884967-8	2015	Both paraquat and chlorpyrifos treatments increased levels of the autophagy inhibitor, mammalian target of rapamycin, mTOR, suggesting impaired axonal autophagy, despite increases in certain autophagic proteins, such as beclin 1 and Atg 12.	Chlorpyrifos	18-30	mechanistic target of rapamycin kinase	Homo sapiens	118-122
26884967-8	2015	Both paraquat and chlorpyrifos treatments increased levels of the autophagy inhibitor, mammalian target of rapamycin, mTOR, suggesting impaired axonal autophagy, despite increases in certain autophagic proteins, such as beclin 1 and Atg 12.	Chlorpyrifos	18-30	beclin 1	Homo sapiens	220-228
26884967-8	2015	Both paraquat and chlorpyrifos treatments increased levels of the autophagy inhibitor, mammalian target of rapamycin, mTOR, suggesting impaired axonal autophagy, despite increases in certain autophagic proteins, such as beclin 1 and Atg 12.	Chlorpyrifos	18-30	autophagy related 12	Homo sapiens	233-239
26210949-0	2015	Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration.	Chlorpyrifos	32-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115
25567057-3	2015	Among the model compounds, only the known acetylcholinesterase inhibitors paraoxon-methyl and chlorpyrifos produced a strong inhibition to about 20 and 33%, respectively, of the negative controls.	Chlorpyrifos	94-106	acetylcholinesterase	Danio rerio	42-62
26314619-4	2015	We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system.	Chlorpyrifos	37-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
26314619-4	2015	We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system.	Chlorpyrifos	37-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
26162960-2	2015	Our recent data highlighted genexenvironment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide.	Chlorpyrifos	219-231	apolipoprotein E	Homo sapiens	85-102
26162960-2	2015	Our recent data highlighted genexenvironment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide.	Chlorpyrifos	219-231	apolipoprotein E	Homo sapiens	104-109
26162960-2	2015	Our recent data highlighted genexenvironment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide.	Chlorpyrifos	219-231	apolipoprotein E	Homo sapiens	185-190
26162960-2	2015	Our recent data highlighted genexenvironment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide.	Chlorpyrifos	233-236	apolipoprotein E	Homo sapiens	85-102
26162960-2	2015	Our recent data highlighted genexenvironment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide.	Chlorpyrifos	233-236	apolipoprotein E	Homo sapiens	104-109
26162960-3	2015	Thus, we aimed to further explore the contribution of the APOE3 genotype on the emergence of obesity and related metabolic dysfunctions upon subchronic exposure to CPF.	Chlorpyrifos	164-167	apolipoprotein E	Homo sapiens	58-63
26070385-0	2015	PINK1/Parkin-mediated mitophagy alleviates chlorpyrifos-induced apoptosis in SH-SY5Y cells.	Chlorpyrifos	43-55	PTEN induced kinase 1	Homo sapiens	0-5
26024810-5	2015	The recombinant BmGSTE2 possessed peroxidase activity and significantly inhibited by fenpropathrin, phoxim and chlorpyrifos in vitro.	Chlorpyrifos	111-123	glutathione S-transferase epsilon 2	Bombyx mori	16-23
26717603-5	2015	We found that a single exposure to 50 mg/kg chlorpyrifos caused a linear decrease in butyryl cholinesterase activity, increased activity of glutathione peroxidase and glutathione reductase, alterations in the levels of glutathione, TBA-active products and lipid hydroperoxides during 1 hour after poisoning.	Chlorpyrifos	44-56	glutathione-disulfide reductase	Rattus norvegicus	167-188
26198043-0	2015	Chlorpyrifos Induces MLL Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells.	Chlorpyrifos	0-12	lysine methyltransferase 2A	Homo sapiens	21-24
26198043-0	2015	Chlorpyrifos Induces MLL Translocations Through Caspase 3-Dependent Genomic Instability and Topoisomerase II Inhibition in Human Fetal Liver Hematopoietic Stem Cells.	Chlorpyrifos	0-12	caspase 3	Homo sapiens	48-57
26215119-1	2015	Parathion and chlorpyrifos are organophosphorus insecticides (OPs) that elicit acute toxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	14-26	acetylcholinesterase	Rattus norvegicus	108-128
26215119-1	2015	Parathion and chlorpyrifos are organophosphorus insecticides (OPs) that elicit acute toxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	14-26	acetylcholinesterase	Rattus norvegicus	130-134
26215119-4	2015	We report the comparative effects of parathion and chlorpyrifos on AChE and enzymes responsible for inactivation of the eCBs, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), and changes in the eCBs AEA and 2AG and eCBLs PEA and OEA, in rat striatum.	Chlorpyrifos	51-63	acetylcholinesterase	Rattus norvegicus	67-71
26215119-4	2015	We report the comparative effects of parathion and chlorpyrifos on AChE and enzymes responsible for inactivation of the eCBs, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), and changes in the eCBs AEA and 2AG and eCBLs PEA and OEA, in rat striatum.	Chlorpyrifos	51-63	fatty-acid amide hydrolase-like	Rattus norvegicus	154-158
26215119-4	2015	We report the comparative effects of parathion and chlorpyrifos on AChE and enzymes responsible for inactivation of the eCBs, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), and changes in the eCBs AEA and 2AG and eCBLs PEA and OEA, in rat striatum.	Chlorpyrifos	51-63	monoglyceride lipase	Rattus norvegicus	189-193
26215119-8	2015	AChE and FAAH were extensively inhibited at both time-points (85-96%), while MAGL activity was significantly but lesser affected (37-62% inhibition) by parathion and chlorpyrifos.	Chlorpyrifos	166-178	monoglyceride lipase	Rattus norvegicus	77-81
26075493-0	2015	Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos.	Chlorpyrifos	61-73	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	38-57
26749865-7	2015	This method has been applied to determine thirteen batches of commercially available samples, chlorpyriphos-ethyl and p,p"-DDE were detected in four batches of Paeoniae Radix Alba.	Chlorpyrifos	94-113	afamin	Homo sapiens	175-179
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	tumor necrosis factor	Homo sapiens	174-201
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	tumor necrosis factor	Homo sapiens	203-212
25857968-4	2015	Furthermore, CPS-F prevents the PDGF receptor beta (PDGFRbeta) promoter activity induced by PDGF-BB in transfected cells and ameliorates increased levels of TNF-alpha, TNFR1, and MCP-1 when PDGFRbeta is silenced, thereby suggesting that CPS-F possesses a bidirectional regulatory function.	Chlorpyrifos	13-18	platelet derived growth factor receptor beta	Homo sapiens	52-61
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	TNF receptor superfamily member 1A	Homo sapiens	215-235
25857968-4	2015	Furthermore, CPS-F prevents the PDGF receptor beta (PDGFRbeta) promoter activity induced by PDGF-BB in transfected cells and ameliorates increased levels of TNF-alpha, TNFR1, and MCP-1 when PDGFRbeta is silenced, thereby suggesting that CPS-F possesses a bidirectional regulatory function.	Chlorpyrifos	13-18	tumor necrosis factor	Homo sapiens	157-166
25857968-4	2015	Furthermore, CPS-F prevents the PDGF receptor beta (PDGFRbeta) promoter activity induced by PDGF-BB in transfected cells and ameliorates increased levels of TNF-alpha, TNFR1, and MCP-1 when PDGFRbeta is silenced, thereby suggesting that CPS-F possesses a bidirectional regulatory function.	Chlorpyrifos	13-18	TNF receptor superfamily member 1A	Homo sapiens	168-173
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	TNF receptor superfamily member 1A	Homo sapiens	237-242
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	C-C motif chemokine ligand 2	Homo sapiens	249-279
25857968-4	2015	Furthermore, CPS-F prevents the PDGF receptor beta (PDGFRbeta) promoter activity induced by PDGF-BB in transfected cells and ameliorates increased levels of TNF-alpha, TNFR1, and MCP-1 when PDGFRbeta is silenced, thereby suggesting that CPS-F possesses a bidirectional regulatory function.	Chlorpyrifos	13-18	C-C motif chemokine ligand 2	Homo sapiens	179-184
25857968-4	2015	Furthermore, CPS-F prevents the PDGF receptor beta (PDGFRbeta) promoter activity induced by PDGF-BB in transfected cells and ameliorates increased levels of TNF-alpha, TNFR1, and MCP-1 when PDGFRbeta is silenced, thereby suggesting that CPS-F possesses a bidirectional regulatory function.	Chlorpyrifos	13-18	platelet derived growth factor receptor beta	Homo sapiens	190-199
25857968-5	2015	Our findings suggest CPS-F may exert its therapeutic effect for the treatment of glomerulonephritis related to human mesangial cells (HMCs) through the ERK1/2/Akt pathways.	Chlorpyrifos	21-26	mitogen-activated protein kinase 3	Homo sapiens	152-158
25857968-5	2015	Our findings suggest CPS-F may exert its therapeutic effect for the treatment of glomerulonephritis related to human mesangial cells (HMCs) through the ERK1/2/Akt pathways.	Chlorpyrifos	21-26	AKT serine/threonine kinase 1	Homo sapiens	159-162
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	C-C motif chemokine ligand 2	Homo sapiens	281-286
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	mitogen-activated protein kinase 3	Homo sapiens	339-343
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	mitogen-activated protein kinase 1	Homo sapiens	344-347
25857968-2	2015	We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002.	Chlorpyrifos	21-26	AKT serine/threonine kinase 1	Homo sapiens	373-376
26111651-5	2015	Among the studied neurotransmitter systems (serotonergic, dopaminergic and cholinergic), increased gene expression was demonstrated for tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) with a corresponding decrease in serotonin receptor 1A (5HTR1A) (p<0.05); no changes in gene expression of choline transporter, PKC beta and D2 were found following chlorpyrifos exposure.	Chlorpyrifos	363-375	tyrosine hydroxylase	Gallus gallus	136-161
25983063-4	2015	In the current study we used zebrafish larvae in order to determine the effects of two of the most widely used organophosphates, chlorpyrifos and malathion, on zebrafish behavior and AChE activity.	Chlorpyrifos	129-141	acetylcholinesterase	Danio rerio	183-187
26199915-1	2015	OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes.	Chlorpyrifos	11-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	239-259
26199915-1	2015	OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes.	Chlorpyrifos	11-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	261-265
26199915-1	2015	OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes.	Chlorpyrifos	11-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	498-502
25682586-4	2015	With oxidation, the sensitivity of HF-AChE to chlorpyrifos (CPF), malathion (MLT) and triazophos (TRZ) increased significantly.	Chlorpyrifos	46-58	acetylcholinesterase-like	Musca domestica	35-42
25747767-0	2015	Chronic exposure to chlorpyrifos triggered body weight increase and memory impairment depending on human apoE polymorphisms in a targeted replacement mouse model.	Chlorpyrifos	20-32	apolipoprotein E	Homo sapiens	105-109
25682586-4	2015	With oxidation, the sensitivity of HF-AChE to chlorpyrifos (CPF), malathion (MLT) and triazophos (TRZ) increased significantly.	Chlorpyrifos	60-63	acetylcholinesterase-like	Musca domestica	35-42
24975276-1	2015	Our previous in vivo studies showed that chlorpyrifos (CPF) and cypermethrin (CM) in a mixture dermally administered, strongly inhibited cholinesterase activity in plasma and the brain and were very toxic to the rat central nervous system.	Chlorpyrifos	41-53	butyrylcholinesterase	Rattus norvegicus	137-151
25972795-0	2015	Strain dependent effects of conditioned fear in adult C57Bl/6 and Balb/C mice following postnatal exposure to chlorpyrifos: relation to expression of brain acetylcholinesterase mRNA.	Chlorpyrifos	110-122	acetylcholinesterase	Mus musculus	156-176
25972795-9	2015	Chlorpyrifos-treated mice had increased expression of both synaptic and readthrough AChE transcripts in the hippocampus of Balb/C mice and decreased expression in the amygdala following fear-conditioning.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	84-88
25732547-3	2015	We show here that resistance to chlorpyrifos, an organophosphate (OP), in Chinese populations of the diamondback moth, Plutella xylostella, is conferred by two mutations of ace1 - the gene encoding the acetylcholinesterase enzyme targeted by OPs - affecting the amino acid sequence of the corresponding protein.	Chlorpyrifos	32-44	acetylcholinesterase-like	Plutella xylostella	173-177
25472879-6	2015	On contrary, both chlorpyriphos and cypermethrin increased the sequestration and degradation of GLI1 by upregulating SU(FU) and betaTrCP, respectively.	Chlorpyrifos	18-31	GLI-Kruppel family member GLI1	Mus musculus	96-100
25472879-6	2015	On contrary, both chlorpyriphos and cypermethrin increased the sequestration and degradation of GLI1 by upregulating SU(FU) and betaTrCP, respectively.	Chlorpyrifos	18-31	SUFU negative regulator of hedgehog signaling	Mus musculus	117-123
25472879-6	2015	On contrary, both chlorpyriphos and cypermethrin increased the sequestration and degradation of GLI1 by upregulating SU(FU) and betaTrCP, respectively.	Chlorpyrifos	18-31	beta-transducin repeat containing protein	Mus musculus	128-136
25543108-0	2015	Derivation of human Biomonitoring Guidance Values for chlorpyrifos using a physiologically based pharmacokinetic and pharmacodynamic model of cholinesterase inhibition.	Chlorpyrifos	54-66	butyrylcholinesterase	Homo sapiens	142-156
24975276-1	2015	Our previous in vivo studies showed that chlorpyrifos (CPF) and cypermethrin (CM) in a mixture dermally administered, strongly inhibited cholinesterase activity in plasma and the brain and were very toxic to the rat central nervous system.	Chlorpyrifos	55-58	butyrylcholinesterase	Rattus norvegicus	137-151
26295817-6	2015	Increased FRET signals, indicative of S aggregation, were observed following treatment of unc-54::SC + unc-54::SV double transgenic worms with low concentrations of mercury or chlorpyrifos, or with RNAi against hsp-70 and hip-1.	Chlorpyrifos	176-188	Myosin-4	Caenorhabditis elegans	103-109
26094523-7	2015	Using these CFD plots, the chronic and acute threshold values were calculated at the 5% cumulative frequency level for chlorpyrifos exposure giving values at 0.5 microg/kg/d and 3 microg/kg/d respectively.	Chlorpyrifos	119-131	gremlin 2, DAN family BMP antagonist	Homo sapiens	172-179
26094523-7	2015	Using these CFD plots, the chronic and acute threshold values were calculated at the 5% cumulative frequency level for chlorpyrifos exposure giving values at 0.5 microg/kg/d and 3 microg/kg/d respectively.	Chlorpyrifos	119-131	gremlin 2, DAN family BMP antagonist	Homo sapiens	37-38
25460623-2	2015	Some pesticides, such as the organophosphorus insecticide chlorpyrifos, appear to increase the expression of alpha-synuclein, a protein critically involved in Parkinson disease.	Chlorpyrifos	58-70	synuclein alpha	Homo sapiens	109-124
25460623-4	2015	Additionally, in age-adjusted linear regression models for repeated measures, we assessed whether alpha-synuclein levels were associated with butyrylcholinesterase-chlorpyrifos adducts or cholinesterase inhibition measured in peripheral blood, or with self-reported pesticide exposure or paraoxonase (PON1) genotype.	Chlorpyrifos	164-176	synuclein alpha	Homo sapiens	98-113
25460623-5	2015	There was no evidence by any of those indicators that exposure to chlorpyrifos was associated with greater blood alpha-synuclein.	Chlorpyrifos	66-78	synuclein alpha	Homo sapiens	113-128
25180937-0	2015	Chlorpyrifos inhibits cell proliferation through ERK1/2 phosphorylation in breast cancer cell lines.	Chlorpyrifos	0-12	mitogen-activated protein kinase 3	Homo sapiens	49-55
26460372-2	2015	The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system.	Chlorpyrifos	51-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-150
26460372-2	2015	The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system.	Chlorpyrifos	65-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-150
25196089-1	2014	Chlorpyrifos (CPF) is an organophosphorus cholinesterase inhibitor widely used as an insecticide.	Chlorpyrifos	0-12	butyrylcholinesterase	Rattus norvegicus	42-56
25142351-7	2014	The results indicated that the P450 content and the NADPH-P450 reductase and antioxidative enzyme (CAT and SOD) activities could be induced by chlorpyrifos and TCP.	Chlorpyrifos	143-155	catalase	Danio rerio	99-102
26257840-0	2015	Chlorpyrifos Induces the Expression of the Epstein-Barr Virus Lytic Cycle Activator BZLF-1 via Reactive Oxygen Species.	Chlorpyrifos	0-12	protein Zta	Human gammaherpesvirus 4	84-90
25196089-1	2014	Chlorpyrifos (CPF) is an organophosphorus cholinesterase inhibitor widely used as an insecticide.	Chlorpyrifos	14-17	butyrylcholinesterase	Rattus norvegicus	42-56
25233012-10	2014	For some triazoles, prochloraz and chlorpyrifos a significant induction of CYP1A1 mRNA expression and potential combination effects for this endpoint were observed.	Chlorpyrifos	35-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	75-81
25438950-0	2014	Apoptotic effects and glucose-6-phosphate dehydrogenase responses in liver and gill tissues of rainbow trout treated with chlorpyrifos.	Chlorpyrifos	122-134	glucose-6-phosphate-1-dehydrogenase	Oncorhynchus mykiss	22-55
25438950-1	2014	We investigated apoptotic effects and changes in glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in liver and gill tissues of fish exposed to chlorpyrifos.	Chlorpyrifos	151-163	glucose-6-phosphate-1-dehydrogenase	Oncorhynchus mykiss	49-82
25438950-1	2014	We investigated apoptotic effects and changes in glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in liver and gill tissues of fish exposed to chlorpyrifos.	Chlorpyrifos	151-163	glucose-6-phosphate-1-dehydrogenase	Oncorhynchus mykiss	84-88
25438950-3	2014	Acute exposure to chlorpyrifos showed time dependent decrease in G6PD enzyme activity at all concentrations (p < 0.05).	Chlorpyrifos	18-30	glucose-6-phosphate-1-dehydrogenase	Oncorhynchus mykiss	65-69
25438950-5	2014	The present study suggested that chlorpyrifos inhibits G6PD enzyme and causes mucous cell loss in gill and apoptosis in gill and liver tissues.	Chlorpyrifos	33-45	glucose-6-phosphate-1-dehydrogenase	Oncorhynchus mykiss	55-59
23418109-7	2014	Treatment with middle- and high-dose chlorpyrifos and MIX in rats significantly inhibited AChE activity in the central nervous tissues, whereas treatment with carbaryl alone did not.	Chlorpyrifos	37-49	acetylcholinesterase	Rattus norvegicus	90-94
23418109-8	2014	In sciatic nerve, AChE activity was significantly inhibited by high-dose carbaryl and MIX, but not by chlorpyrifos alone.	Chlorpyrifos	102-114	acetylcholinesterase	Rattus norvegicus	18-22
24200834-7	2014	At oral doses >=0.6mg/kg of chlorpyrifos (100- to 1000-fold higher than environmental exposure levels), 6months old children are predicted to have higher levels of chlorpyrifos-oxon in blood and higher levels of red blood cell cholinesterase inhibition compared to adults from equivalent doses.	Chlorpyrifos	31-43	butyrylcholinesterase	Homo sapiens	230-244
23364943-9	2014	A significant increase in the activities of LDH and LDH-x was observed in chlorpyrifos exposed rats in 5.4 and 12.8 mg/kg groups, but the expression levels of related genes had no significant differences between chlorpyrifos exposure groups and the control group.	Chlorpyrifos	74-86	lactate dehydrogenase C	Rattus norvegicus	52-57
25175646-0	2014	Characterization and expression analysis of peroxiredoxin family genes from the silkworm Bombyx mori in response to phoxim and chlorpyrifos.	Chlorpyrifos	127-139	peroxiredoxin	Bombyx mori	44-57
25158275-0	2014	Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes.	Chlorpyrifos	108-120	butyrylcholinesterase	Mus musculus	38-52
24833556-3	2014	The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls.	Chlorpyrifos	90-102	butyrylcholinesterase	Homo sapiens	214-228
24833556-3	2014	The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls.	Chlorpyrifos	90-102	butyrylcholinesterase	Homo sapiens	230-233
24833556-3	2014	The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls.	Chlorpyrifos	104-107	butyrylcholinesterase	Homo sapiens	214-228
24833556-3	2014	The objectives of this study are to estimate exposures to the organophosphorus pesticide, chlorpyrifos (CPF), by measuring urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific CPF metabolite, and blood cholinesterase (ChE) activities and to characterize neurobehavioral performance in adolescents working as seasonal pesticide applicators and non-applicator controls.	Chlorpyrifos	104-107	butyrylcholinesterase	Homo sapiens	230-233
24955152-0	2014	Effects of intralipid and caffeic acid phenethyl ester on neurotoxicity, oxidative stress, and acetylcholinesterase activity in acute chlorpyriphos intoxication.	Chlorpyrifos	134-147	acetylcholinesterase	Rattus norvegicus	95-115
24373905-1	2014	The prevailing dogma is that chlorpyrifos (CPF) mediates its toxicity through inhibition of cholinesterase (ChE).	Chlorpyrifos	29-41	butyrylcholinesterase	Rattus norvegicus	92-106
24373905-1	2014	The prevailing dogma is that chlorpyrifos (CPF) mediates its toxicity through inhibition of cholinesterase (ChE).	Chlorpyrifos	29-41	butyrylcholinesterase	Rattus norvegicus	108-111
24373905-1	2014	The prevailing dogma is that chlorpyrifos (CPF) mediates its toxicity through inhibition of cholinesterase (ChE).	Chlorpyrifos	43-46	butyrylcholinesterase	Rattus norvegicus	92-106
24373905-1	2014	The prevailing dogma is that chlorpyrifos (CPF) mediates its toxicity through inhibition of cholinesterase (ChE).	Chlorpyrifos	43-46	butyrylcholinesterase	Rattus norvegicus	108-111
24510408-6	2014	The results also showed that responses of candidate genes to different chemicals were distinct, 18S rRNA was the best for BalphaP and chlorpyrifos, tba-1 was the most stable gene for diazinon and gossypol treatments, while pmp-3 was more stable for zinc oxide exposure.	Chlorpyrifos	134-146	Tubulin alpha chain	Caenorhabditis elegans	148-153
24727577-0	2014	Nuclear NF-kappaB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells.	Chlorpyrifos	33-45	nuclear factor kappa B subunit 1	Homo sapiens	8-17
24727577-0	2014	Nuclear NF-kappaB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells.	Chlorpyrifos	33-45	tumor protein p53	Homo sapiens	72-75
32261711-4	2014	The designed biosensor with synergic properties between the high conductivity of iridium oxide nanoparticles, low-cost screen printed electrodes and the efficiency of tyrosinase shows broad linearity ranges for catechol and chlorpyrifos detection.	Chlorpyrifos	224-236	tyrosinase	Homo sapiens	167-177
32261711-5	2014	Using this biosensor, very low limits of detection for catechol (0.08 muM) and chlorpyrifos (0.003 muM) are observed and recoveries of spiked tap and river water samples have also been studied showing very good recoveries.	Chlorpyrifos	79-91	latexin	Homo sapiens	99-102
24979751-0	2014	Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult.	Chlorpyrifos	60-72	paraoxonase 1	Homo sapiens	0-11
24979751-5	2014	In this study the defense of the ARPE19 cells exposed to Chlorpyrifos (1 nM to 100 microM) in terms of the enzyme paraoxonase (PON) was studied at 24 hr and 9 days of treatment.	Chlorpyrifos	57-69	paraoxonase 1	Homo sapiens	114-125
24979751-5	2014	In this study the defense of the ARPE19 cells exposed to Chlorpyrifos (1 nM to 100 microM) in terms of the enzyme paraoxonase (PON) was studied at 24 hr and 9 days of treatment.	Chlorpyrifos	57-69	paraoxonase 1	Homo sapiens	127-130
24979751-7	2014	Tissue resident Paraoxonase 2 (PON2) mRNA expression was elevated with chlorpyrifos exposure.	Chlorpyrifos	71-83	paraoxonase 2	Homo sapiens	16-29
24979751-7	2014	Tissue resident Paraoxonase 2 (PON2) mRNA expression was elevated with chlorpyrifos exposure.	Chlorpyrifos	71-83	paraoxonase 2	Homo sapiens	31-35
24979751-9	2014	Among the transcription factors regulating PON2 expression, SP1 was significantly increased with chlorpyrifos exposure.	Chlorpyrifos	97-109	paraoxonase 2	Homo sapiens	43-47
24979751-10	2014	PON2 expression was found to be crucial as ARPE19 cells showed a significant loss in their ability to withstand oxidative stress when the cells were subjected to chlorpyrifos after silencing PON2 expression.	Chlorpyrifos	162-174	paraoxonase 2	Homo sapiens	0-4
24979751-11	2014	Treatment with N-acetyl cysteine positively regulated the PON 2 expression, thus promoting the antioxidant defense put up by the cells in response to chlorpyrifos.	Chlorpyrifos	150-162	paraoxonase 2	Homo sapiens	58-63
24849677-1	2014	Chlorpyrifos (CPF) is an organophosphate compound that is slowly delivered in the organism after subcutaneous injection, keeping acetylcholinesterase (AChE) activity mildly inhibited for weeks.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	129-149
24849677-1	2014	Chlorpyrifos (CPF) is an organophosphate compound that is slowly delivered in the organism after subcutaneous injection, keeping acetylcholinesterase (AChE) activity mildly inhibited for weeks.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	151-155
24849677-1	2014	Chlorpyrifos (CPF) is an organophosphate compound that is slowly delivered in the organism after subcutaneous injection, keeping acetylcholinesterase (AChE) activity mildly inhibited for weeks.	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	129-149
24849677-1	2014	Chlorpyrifos (CPF) is an organophosphate compound that is slowly delivered in the organism after subcutaneous injection, keeping acetylcholinesterase (AChE) activity mildly inhibited for weeks.	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	151-155
24955152-8	2014	RESULTS: Serum enzym levels showed that chlorpyriphos and CAPE inhibited AChE while IL alone had no effect, chlorpyriphos and CAPE intensifies the inhibition effect.	Chlorpyrifos	40-53	acetylcholinesterase	Rattus norvegicus	73-77
24394474-7	2014	The results showed reductions in the activities of brain antioxidant enzymes and acetylcholinesterase, increased lipoperoxidation and histopathological alterations of the cerebral cortex in the CPF+LA group.	Chlorpyrifos	194-197	acetylcholinesterase	Rattus norvegicus	81-101
24292926-5	2014	Rats treated orally with chlorpyrifos [89.4 mg/kg body weight (BW)] for 15 consecutive days showed changes in brain lipid profile, increased levels of lipid peroxidation, inhibition of acetylcholinesterase activity, and changes in antioxidant enzymes.	Chlorpyrifos	25-37	acetylcholinesterase	Rattus norvegicus	185-205
24292926-8	2014	Alterations caused by neurotoxic effects of chlorpyrifos were attenuated by EO administration with decreased protein expressions of caspase-3.	Chlorpyrifos	44-56	caspase 3	Rattus norvegicus	132-141
23933531-1	2013	Parathion (PS) and chlorpyrifos (CPF) are organophosphorus insecticides (OPs) that elicit acute toxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	19-31	acetylcholinesterase	Rattus norvegicus	119-139
24534502-0	2014	Short communication: interaction of bovine milk protein with chlorpyrifos.	Chlorpyrifos	61-73	Weaning weight-maternal milk	Bos taurus	43-47
24534502-3	2014	The organophosphate insecticide chlorpyrifos has been reported to bind with human and bovine serum albumin.	Chlorpyrifos	32-44	albumin	Homo sapiens	93-106
24534502-5	2014	In this study, equilibrium dialysis and fluorescence spectra were used to demonstrate binding of milk proteins to chlorpyrifos.	Chlorpyrifos	114-126	Weaning weight-maternal milk	Bos taurus	97-101
24534502-7	2014	Moreover, the milk protein-chlorpyrifos complexes were stable at pH 3.5to 9.5 and ion concentrations from 0.1 to 1.0M.	Chlorpyrifos	27-39	Weaning weight-maternal milk	Bos taurus	14-18
24534502-8	2014	The amount of chlorpyrifos bound to milk proteins decreased to 50% after being in vitro digested by pepsin and trypsin.	Chlorpyrifos	14-26	Weaning weight-maternal milk	Bos taurus	36-40
23994500-9	2013	OPC exposure caused a significant concentration-dependent influence on DC: Dendrites of the DC were shortened and damaged, DC-specific cell surface markers (i.e., CD83and CD209) decreased dramatically after chlorpyrifos exposure.	Chlorpyrifos	207-219	CD83 molecule	Homo sapiens	163-167
23994500-9	2013	OPC exposure caused a significant concentration-dependent influence on DC: Dendrites of the DC were shortened and damaged, DC-specific cell surface markers (i.e., CD83and CD209) decreased dramatically after chlorpyrifos exposure.	Chlorpyrifos	207-219	CD209 molecule	Homo sapiens	171-176
23933531-1	2013	Parathion (PS) and chlorpyrifos (CPF) are organophosphorus insecticides (OPs) that elicit acute toxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	19-31	acetylcholinesterase	Rattus norvegicus	141-145
23933531-1	2013	Parathion (PS) and chlorpyrifos (CPF) are organophosphorus insecticides (OPs) that elicit acute toxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	33-36	acetylcholinesterase	Rattus norvegicus	119-139
23933531-1	2013	Parathion (PS) and chlorpyrifos (CPF) are organophosphorus insecticides (OPs) that elicit acute toxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	33-36	acetylcholinesterase	Rattus norvegicus	141-145
23933531-3	2013	We proposed that differential inhibition of eCB-degrading enzymes (fatty acid amide hydrolase, FAAH, and monoacylglycerol lipase, MAGL) by PS and CPF leads to differences in extracellular eCB levels and toxicity.	Chlorpyrifos	146-149	fatty-acid amide hydrolase-like	Rattus norvegicus	95-99
23933531-3	2013	We proposed that differential inhibition of eCB-degrading enzymes (fatty acid amide hydrolase, FAAH, and monoacylglycerol lipase, MAGL) by PS and CPF leads to differences in extracellular eCB levels and toxicity.	Chlorpyrifos	146-149	monoglyceride lipase	Rattus norvegicus	105-128
23933531-3	2013	We proposed that differential inhibition of eCB-degrading enzymes (fatty acid amide hydrolase, FAAH, and monoacylglycerol lipase, MAGL) by PS and CPF leads to differences in extracellular eCB levels and toxicity.	Chlorpyrifos	146-149	monoglyceride lipase	Rattus norvegicus	130-134
23933531-7	2013	Cholinesterase inhibition was extensive in hippocampus with PS (89-90%) and CPF (78-83%) exposure.	Chlorpyrifos	76-79	butyrylcholinesterase	Rattus norvegicus	0-14
22634058-4	2013	Chlorpyrifos and fenitrothion were most effective in inhibiting CYP1A1/2, and CYP2B6.	Chlorpyrifos	0-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70
24159863-2	2013	The experimental results indicated that the adsorption process of Pb(II) and chlorpyrifos on loess fit better the Langmuir isotherm, the maximum adsorption capacity of q(m) is 12.5 and 0.64 mg x g(-1) for Pb(II) and chlorpyrifos on loess, respectively, and the reaction could be illustrated with pseudo-second order kinetic equation.	Chlorpyrifos	77-89	submaxillary gland androgen regulated protein 3B	Homo sapiens	205-211
24159863-2	2013	The experimental results indicated that the adsorption process of Pb(II) and chlorpyrifos on loess fit better the Langmuir isotherm, the maximum adsorption capacity of q(m) is 12.5 and 0.64 mg x g(-1) for Pb(II) and chlorpyrifos on loess, respectively, and the reaction could be illustrated with pseudo-second order kinetic equation.	Chlorpyrifos	216-228	submaxillary gland androgen regulated protein 3B	Homo sapiens	66-72
23689095-7	2013	Chlorpyrifos was hydrolyzed to 3,5,6-tricholorpyridinol (TCP) which was further degraded only in compost-biomixture CBX1.	Chlorpyrifos	0-12	chromobox 1	Homo sapiens	116-120
22634058-4	2013	Chlorpyrifos and fenitrothion were most effective in inhibiting CYP1A1/2, and CYP2B6.	Chlorpyrifos	0-12	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	78-84
22884923-1	2013	Paraoxonase (PON1) is an A-esterase capable of hydrolyzing the active metabolites (oxons) of a number of organophosphorus (OP) insecticides such as parathion, diazinon and chlorpyrifos.	Chlorpyrifos	172-184	paraoxonase 1	Homo sapiens	13-17
23622518-0	2013	Effect of chlorpyrifos on the inhibition of the enzyme acetylcholinesterase by cross-linking in water-supply samples and milk from dairy cattle.	Chlorpyrifos	10-22	acetylcholinesterase	Bos taurus	55-75
23590812-0	2013	Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients.	Chlorpyrifos	0-12	butyrylcholinesterase	Homo sapiens	45-59
23524272-7	2013	Therefore, regulatory exposure limits for chlorpyrifos, which are based on cholinesterase inhibition, are sufficient to protect against potential endocrine alterations.	Chlorpyrifos	42-54	butyrylcholinesterase	Homo sapiens	75-89
23545134-0	2013	Chronic dietary exposure to chlorpyrifos causes behavioral impairments, low activity of brain membrane-bound acetylcholinesterase, and increased brain acetylcholinesterase-R mRNA.	Chlorpyrifos	28-40	acetylcholinesterase	Rattus norvegicus	109-129
23545134-0	2013	Chronic dietary exposure to chlorpyrifos causes behavioral impairments, low activity of brain membrane-bound acetylcholinesterase, and increased brain acetylcholinesterase-R mRNA.	Chlorpyrifos	28-40	acetylcholinesterase	Rattus norvegicus	151-171
23416429-5	2013	Prenatal exposure to CPF and DZN induced a transient reduction of NADPH-d(+)/nNOS-immunoreactive (IR) neurons in most cortical regions on PND 4 but exceptionally increased them in the entorhinal/piriform cortex.	Chlorpyrifos	21-24	nitric oxide synthase 1	Rattus norvegicus	77-81
23202341-5	2013	Based on the inhibition of pesticides on the AChE activity, using malathion, chlorpyrifos, monocrotophos and carbofuran as model compounds, this biosensor showed a wide range, low detection limit, good reproducibility and high stability.	Chlorpyrifos	77-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
23416140-0	2013	JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis.	Chlorpyrifos	76-88	mitogen-activated protein kinase 8	Homo sapiens	0-3
23416140-0	2013	JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis.	Chlorpyrifos	76-88	mitogen-activated protein kinase 1	Homo sapiens	8-11
23416140-1	2013	To investigate mechanisms of neuronal cell death in response to chlorpyrifos (CPF), a pesticide, we evaluated the regulation of ROS and COX-2 in human neuroblastoma SH-SY5Y cells treated with CPF.	Chlorpyrifos	64-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
24766444-8	2013	The carboxylesterase activity in P. xylostella showed positive correlations with the resistance to spinosad, beta-cypermethrin, chlorpyrifos, and abamectin, but no correlation was observed between the carboxylesterase activity and resistance to emamectin benzoate, between glutathione S-transferase activity and resistance to any of the five pesticides tested, or between acetylcholine esterase activity and any of the pesticides except for emamectin benzoate.	Chlorpyrifos	128-140	esterase B1-like	Plutella xylostella	4-20
23386834-8	2013	Biochemical assays confirmed that the four compounds we assayed (coumaphos, aldicarb, chlorpyrifos, and donepezil) or their metabolites acted as AChE inhibitors in bees.	Chlorpyrifos	86-98	acetylcholinesterase	Apis mellifera	145-149
23878805-5	2013	Plasma AChE activity was decreased, while LDH, ALT, GGT, and AST activities were increased in chlorpyrifos group compared to control groups.	Chlorpyrifos	94-106	acetylcholinesterase	Rattus norvegicus	7-11
23535398-3	2013	However, we observed long term deficit after acute subcutaneous exposure to Chlorpyrifos (CPF) even when AChE activity is restored.	Chlorpyrifos	76-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
22975224-1	2012	Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF).	Chlorpyrifos	124-136	paraoxonase 1	Homo sapiens	31-44
24283477-6	2013	Cytochrome P-450 and cytochrome b 5 levels and activities of aniline p-hydroxylase (APH) and uridine diphosphate glucuronosyltransferase (UGT) were significantly decreased in groups treated with As, CPF, and As plus CPF, while glutathione S-transferase (GST) was not markedly altered.	Chlorpyrifos	199-202	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
24283477-6	2013	Cytochrome P-450 and cytochrome b 5 levels and activities of aniline p-hydroxylase (APH) and uridine diphosphate glucuronosyltransferase (UGT) were significantly decreased in groups treated with As, CPF, and As plus CPF, while glutathione S-transferase (GST) was not markedly altered.	Chlorpyrifos	199-202	cytochrome b5 type A	Rattus norvegicus	21-35
24283477-6	2013	Cytochrome P-450 and cytochrome b 5 levels and activities of aniline p-hydroxylase (APH) and uridine diphosphate glucuronosyltransferase (UGT) were significantly decreased in groups treated with As, CPF, and As plus CPF, while glutathione S-transferase (GST) was not markedly altered.	Chlorpyrifos	216-219	cytochrome b5 type A	Rattus norvegicus	21-35
22975224-1	2012	Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF).	Chlorpyrifos	124-136	paraoxonase 1	Homo sapiens	46-50
22975224-1	2012	Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF).	Chlorpyrifos	138-141	paraoxonase 1	Homo sapiens	31-44
22975224-1	2012	Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF).	Chlorpyrifos	138-141	paraoxonase 1	Homo sapiens	46-50
22775490-0	2012	Bioactivation of chlorpyrifos by CYP2B6 variants.	Chlorpyrifos	17-29	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	33-39
22985519-0	2012	Hyper-phosphorylation of GSK-3beta: possible roles in chlorpyrifos-induced behavioral alterations in animal model of depression.	Chlorpyrifos	54-66	glycogen synthase kinase 3 beta	Rattus norvegicus	25-34
23084066-4	2012	In particular, atrazine and diuron were detected with a limit of detection of 0.5nM, with an RSD% less than 5%; paraoxon and chlorpyrifos were revealed with a detection of 5 muM and 4.5 muM, respectively, with an RSD% less than 6%; catechol and bisphenol A were identified with a limit of detection of 1 muM and 35 muM respectively, with an RSD% less than 5%.	Chlorpyrifos	125-137	latexin	Homo sapiens	174-177
23084066-4	2012	In particular, atrazine and diuron were detected with a limit of detection of 0.5nM, with an RSD% less than 5%; paraoxon and chlorpyrifos were revealed with a detection of 5 muM and 4.5 muM, respectively, with an RSD% less than 6%; catechol and bisphenol A were identified with a limit of detection of 1 muM and 35 muM respectively, with an RSD% less than 5%.	Chlorpyrifos	125-137	latexin	Homo sapiens	186-189
23084066-4	2012	In particular, atrazine and diuron were detected with a limit of detection of 0.5nM, with an RSD% less than 5%; paraoxon and chlorpyrifos were revealed with a detection of 5 muM and 4.5 muM, respectively, with an RSD% less than 6%; catechol and bisphenol A were identified with a limit of detection of 1 muM and 35 muM respectively, with an RSD% less than 5%.	Chlorpyrifos	125-137	latexin	Homo sapiens	186-189
23084066-4	2012	In particular, atrazine and diuron were detected with a limit of detection of 0.5nM, with an RSD% less than 5%; paraoxon and chlorpyrifos were revealed with a detection of 5 muM and 4.5 muM, respectively, with an RSD% less than 6%; catechol and bisphenol A were identified with a limit of detection of 1 muM and 35 muM respectively, with an RSD% less than 5%.	Chlorpyrifos	125-137	latexin	Homo sapiens	186-189
22985519-9	2012	These results suggest a noncholinergic mechanism, the hyper-phosphorylation of GSK-3beta, which may contribute to the cellular neurotoxicity of CPF, thus increasing the susceptibility to mood disorders.	Chlorpyrifos	144-147	glycogen synthase kinase 3 beta	Rattus norvegicus	79-88
22180373-5	2012	Moreover, expression patterns of the genes spe-10, spe-15, fer-1, prg-1, glp-1, mlh-1, cyb-3, ced-3, ced-4 and ced-9 (which are associated with spermatid size, spermatid activation and morphology, oocyte morphology, oocyte function, and apoptosis) were altered after chlorpyrifos exposure.	Chlorpyrifos	267-279	Apoptosis regulator ced-9	Caenorhabditis elegans	111-116
22732190-7	2012	In addition, flow cytometry analysis of the neuron-specific marker protein MAP2 on day 12 after induction of differentiation demonstrated a concentration dependent effect of the neurodevelopmental toxicants methylmercury chloride, chlorpyrifos, and lead acetate on neuronal differentiation.	Chlorpyrifos	231-243	microtubule-associated protein 2	Mus musculus	75-79
22683313-8	2012	Increased maternal PON1 levels were associated with decreased odds of chlorpyrifos and diazinon detection (odds ratio(OR): 0.56 and 0.75, respectively).	Chlorpyrifos	70-82	paraoxonase 1	Homo sapiens	19-23
23021811-6	2012	The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively.	Chlorpyrifos	160-172	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-65
23021811-6	2012	The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively.	Chlorpyrifos	160-172	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
22842080-9	2012	The morphological studies showed extensive condensed nucleus and enlarged intercellular spaces in the CA1 and DG sub-regions in the dHPC of the CPF-treated males and the DG sub-region of the CPF-treated females.	Chlorpyrifos	144-147	carbonic anhydrase 1	Mus musculus	102-105
22714038-2	2012	In this study we found that chlorpyrifos (CPF) induced apoptosis in dopaminergic neuronal components of PC12 cells as demonstrated by the activation of caspases and nuclear condensation.	Chlorpyrifos	28-40	caspase 9	Rattus norvegicus	152-160
22714038-2	2012	In this study we found that chlorpyrifos (CPF) induced apoptosis in dopaminergic neuronal components of PC12 cells as demonstrated by the activation of caspases and nuclear condensation.	Chlorpyrifos	42-45	caspase 9	Rattus norvegicus	152-160
22466357-7	2012	Several environmental toxicants activate HR96 including estradiol, pyriproxyfen, chlorpyrifos, atrazine, and methane arsonate.	Chlorpyrifos	81-93	Hormone receptor-like in 96	Drosophila melanogaster	41-45
22316628-0	2012	Spectroscopic, structural and thermodynamic properties of chlorpyrifos bound to serum albumin: A comparative study between BSA and HSA.	Chlorpyrifos	58-70	albumin	Homo sapiens	80-93
22504667-0	2012	Cholinesterase inhibition and toxicokinetics in immature and adult rats after acute or repeated exposures to chlorpyrifos or chlorpyrifos-oxon.	Chlorpyrifos	109-121	butyrylcholinesterase	Rattus norvegicus	0-14
22504667-1	2012	The effect of age or dose regimen on cholinesterase inhibition (ChEI) from chlorpyrifos (CPF) or CPF-oxon (CPFO) was studied in Crl:CD(SD) rats.	Chlorpyrifos	75-87	butyrylcholinesterase	Rattus norvegicus	37-51
22504667-1	2012	The effect of age or dose regimen on cholinesterase inhibition (ChEI) from chlorpyrifos (CPF) or CPF-oxon (CPFO) was studied in Crl:CD(SD) rats.	Chlorpyrifos	89-92	butyrylcholinesterase	Rattus norvegicus	37-51
22446730-0	2012	Acetylcholinesterase inhibition dose-response modeling for chlorpyrifos and chlorpyrifos-oxon.	Chlorpyrifos	59-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
22446730-1	2012	This paper evaluates new data for cholinesterase inhibition with chlorpyrifos (CPF).	Chlorpyrifos	65-77	butyrylcholinesterase	Homo sapiens	34-48
22446730-1	2012	This paper evaluates new data for cholinesterase inhibition with chlorpyrifos (CPF).	Chlorpyrifos	79-82	butyrylcholinesterase	Homo sapiens	34-48
22406659-12	2012	In contrast plasma AChE activity returned to normal after 24-72 h. In conclusion MALDI-TOF mass spectrometry can be used to diagnose exposure to chlorpyrifos oxon days after AChE inhibition assays are uninformative.	Chlorpyrifos	145-157	acetylcholinesterase	Mus musculus	19-23
22406659-12	2012	In contrast plasma AChE activity returned to normal after 24-72 h. In conclusion MALDI-TOF mass spectrometry can be used to diagnose exposure to chlorpyrifos oxon days after AChE inhibition assays are uninformative.	Chlorpyrifos	145-157	acetylcholinesterase	Mus musculus	174-178
22310847-9	2012	After recovery period, the low concentration group of chlorpyrifos provided a protection in AChE activity during recovery, but fish were observed to be unable to overcome the inhibition of AChE activity at high concentration groups.	Chlorpyrifos	54-66	acetylcholinesterase	Oreochromis niloticus	92-96
22425525-5	2012	PON1 knockout (PON1-/-) mice, which lack PON1, represent a highly sensitive mouse model for toxicity associated with exposure to CPF or CPO.	Chlorpyrifos	129-132	paraoxonase 1	Mus musculus	0-4
22316628-1	2012	Chlorpyrifos (CPF) is a widely used organophosphate insecticide which could bind with human serum albumin (HSA) and bovine serum albumin (BSA).	Chlorpyrifos	0-12	albumin	Homo sapiens	92-105
22316628-1	2012	Chlorpyrifos (CPF) is a widely used organophosphate insecticide which could bind with human serum albumin (HSA) and bovine serum albumin (BSA).	Chlorpyrifos	0-12	albumin	Homo sapiens	123-136
22316628-1	2012	Chlorpyrifos (CPF) is a widely used organophosphate insecticide which could bind with human serum albumin (HSA) and bovine serum albumin (BSA).	Chlorpyrifos	14-17	albumin	Homo sapiens	92-105
22316628-1	2012	Chlorpyrifos (CPF) is a widely used organophosphate insecticide which could bind with human serum albumin (HSA) and bovine serum albumin (BSA).	Chlorpyrifos	14-17	albumin	Homo sapiens	123-136
22281205-0	2012	Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism.	Chlorpyrifos	45-57	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	23-30
22287024-0	2012	Rat brain CYP2B-enzymatic activation of chlorpyrifos to the oxon mediates cholinergic neurotoxicity.	Chlorpyrifos	40-52	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	10-15
22287024-1	2012	Chlorpyrifos is a commonly used insecticide that can be metabolically activated by CYP2B to the acetylcholinesterase inhibitor chlorpyrifos-oxon causing cholinergic overstimulation and neurotoxicity.	Chlorpyrifos	0-12	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	83-88
22287024-5	2012	ICV CYP2B MBIs increased brain chlorpyrifos levels, decreased brain chlorpyrifos-oxon levels, and attenuated the reduction in brain acetylcholinesterase; there was no effect on serum chlorpyrifos levels or acetylcholinesterase activity reduction.	Chlorpyrifos	31-43	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	4-9
22287024-5	2012	ICV CYP2B MBIs increased brain chlorpyrifos levels, decreased brain chlorpyrifos-oxon levels, and attenuated the reduction in brain acetylcholinesterase; there was no effect on serum chlorpyrifos levels or acetylcholinesterase activity reduction.	Chlorpyrifos	68-80	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	4-9
22287024-6	2012	Inhibition of brain chlorpyrifos metabolism by CYP2B MBIs blocked centrally mediated hypothermia but not peripherally mediated hyperthermia.	Chlorpyrifos	20-32	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	47-52
22287024-9	2012	Thus, rat brain CYP2B contributes significantly to chlorpyrifos"s neurotoxic effects.	Chlorpyrifos	51-63	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	16-21
22281205-0	2012	Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism.	Chlorpyrifos	45-57	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	10-16
22209726-3	2012	By the end of the fourth week, chlorpyrifos alone increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), while decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities compared with the control group in rat testis tissues.	Chlorpyrifos	31-43	catalase	Rattus norvegicus	135-138
22209726-3	2012	By the end of the fourth week, chlorpyrifos alone increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), while decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities compared with the control group in rat testis tissues.	Chlorpyrifos	31-43	catalase	Rattus norvegicus	125-133
22209726-3	2012	By the end of the fourth week, chlorpyrifos alone increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), while decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities compared with the control group in rat testis tissues.	Chlorpyrifos	31-43	hematopoietic prostaglandin D synthase	Rattus norvegicus	190-215
22209726-3	2012	By the end of the fourth week, chlorpyrifos alone increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), while decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities compared with the control group in rat testis tissues.	Chlorpyrifos	31-43	hematopoietic prostaglandin D synthase	Rattus norvegicus	217-220
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Chlorpyrifos	21-33	catalase	Rattus norvegicus	143-146
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Chlorpyrifos	21-33	hematopoietic prostaglandin D synthase	Rattus norvegicus	183-186
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Chlorpyrifos	53-65	catalase	Rattus norvegicus	143-146
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Chlorpyrifos	53-65	hematopoietic prostaglandin D synthase	Rattus norvegicus	183-186
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Chlorpyrifos	53-65	catalase	Rattus norvegicus	143-146
22209726-4	2012	In the catechin-plus-chlorpyrifos and quercetin-plus-chlorpyrifos groups, there were statistically significantly decreased MDA levels, SOD and CAT activities, while increased GPx and GST activities compared with the chlorpyrifos-only group.	Chlorpyrifos	53-65	hematopoietic prostaglandin D synthase	Rattus norvegicus	183-186
23020043-5	2012	The present study attempts to define the influence of chlorpyrifos on the profile of subpopulations of immunoactive cells: B, T, CD4+, CD8+, and NK, and on their phagocytic activity in an experimental in vivo model.	Chlorpyrifos	54-66	Cd4 molecule	Rattus norvegicus	129-132
21922192-1	2012	Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	58-78
21922192-1	2012	Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly.	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
21922192-1	2012	Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly.	Chlorpyrifos	14-17	acetylcholinesterase	Mus musculus	58-78
21922192-1	2012	Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly.	Chlorpyrifos	14-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
21922192-5	2012	Although reduced in both age-groups exposed to CPF, percentage of reduction in serum AChE was more in adult compared to the young.	Chlorpyrifos	47-50	acetylcholinesterase	Mus musculus	85-89
22352331-2	2012	Both CYP2B6 and CYP2C19 are pharmacologically and toxicologically relevant due to their ability to metabolize multiple drugs and environmental contaminants, including the organophosphorus (OP) pesticide chlorpyrifos.	Chlorpyrifos	203-215	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	5-11
22352331-2	2012	Both CYP2B6 and CYP2C19 are pharmacologically and toxicologically relevant due to their ability to metabolize multiple drugs and environmental contaminants, including the organophosphorus (OP) pesticide chlorpyrifos.	Chlorpyrifos	203-215	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	16-23
22352331-3	2012	The aim of this study was to determine the prevalence of CYP2B6 and CYP2C19 variants in an indigenous Egyptian population (n = 120) that was shown to be occupationally exposed to chlorpyrifos.	Chlorpyrifos	179-191	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	57-63
22352331-3	2012	The aim of this study was to determine the prevalence of CYP2B6 and CYP2C19 variants in an indigenous Egyptian population (n = 120) that was shown to be occupationally exposed to chlorpyrifos.	Chlorpyrifos	179-191	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	68-75
21948870-4	2012	However, repeated exposure to acetylcholinesterase inhibitors, such as chlorpyrifos (CPF), pyridostigmine, and sarin nerve agent, has been epidemiologically linked to delayed onset symptoms in Gulf War Illness and may be relevant to environmental exposure in farm workers among others.	Chlorpyrifos	71-83	acetylcholinesterase	Mus musculus	30-50
21948870-4	2012	However, repeated exposure to acetylcholinesterase inhibitors, such as chlorpyrifos (CPF), pyridostigmine, and sarin nerve agent, has been epidemiologically linked to delayed onset symptoms in Gulf War Illness and may be relevant to environmental exposure in farm workers among others.	Chlorpyrifos	85-88	acetylcholinesterase	Mus musculus	30-50
21592053-0	2011	Amyloid beta peptide levels increase in brain of AbetaPP Swedish mice after exposure to chlorpyrifos.	Chlorpyrifos	88-100	amyloid beta (A4) precursor protein	Mus musculus	49-56
22100607-11	2012	Consistent with the results for the IC(50) values, the order of reactivity for each of the three oxons with CES1 and CES2 was chlorpyrifos oxon>paraoxon>methyl paraoxon.	Chlorpyrifos	126-138	carboxylesterase 1	Homo sapiens	108-112
22100607-11	2012	Consistent with the results for the IC(50) values, the order of reactivity for each of the three oxons with CES1 and CES2 was chlorpyrifos oxon>paraoxon>methyl paraoxon.	Chlorpyrifos	126-138	carboxylesterase 2	Homo sapiens	117-121
21907274-5	2011	In the present study, we analyzed the effects of methyl parathion and chlorpyrifos on GSTA1 gene expression in HepG2 cells using real time PCR, and activity and immunoreactive protein assays.	Chlorpyrifos	70-82	glutathione S-transferase alpha 1	Homo sapiens	86-91
21907274-6	2011	The results demonstrated that exposure to methyl parathion and chlorpyrifos increased the level of GSTA1 mRNA, GSTA1 immunoreactive protein and GST activity relative to a control.	Chlorpyrifos	63-75	glutathione S-transferase alpha 1	Homo sapiens	99-104
21907274-6	2011	The results demonstrated that exposure to methyl parathion and chlorpyrifos increased the level of GSTA1 mRNA, GSTA1 immunoreactive protein and GST activity relative to a control.	Chlorpyrifos	63-75	glutathione S-transferase alpha 1	Homo sapiens	111-116
21907274-6	2011	The results demonstrated that exposure to methyl parathion and chlorpyrifos increased the level of GSTA1 mRNA, GSTA1 immunoreactive protein and GST activity relative to a control.	Chlorpyrifos	63-75	glutathione S-transferase kappa 1	Homo sapiens	99-102
21907274-8	2011	In conclusion, HepG2 cell cultures treated with methyl parathion and chlorpyrifos could be a useful model for studying the function of GSTA1 and its role in the metabolism of xenobiotics in the liver.	Chlorpyrifos	69-81	glutathione S-transferase alpha 1	Homo sapiens	135-140
21856330-6	2011	Two OP compounds, malathion and chlorpyrifos could be detected in the range of 0.1-100 nM and 0.1-70 nM, respectively at 2.0-3.0% inhibition level of AChE.	Chlorpyrifos	32-44	acetylcholinesterase	Rattus norvegicus	150-154
21873044-3	2011	Under optimum conditions (phosphate buffer, pH 7.5 and 30 C), the inhibition of AChE by malathion and chlorpyrifos was proportional to their concentrations in the range, 0.1-50nM and 1.5-40nM, respectively.	Chlorpyrifos	102-114	acetylcholinesterase	Rattus norvegicus	80-84
22085162-1	2011	We used a hypothesis-based weight-of-evidence (HBWoE) approach to analyze the evidence regarding the hypothesis that chlorpyrifos can cause neurodevelopmental effects below the threshold for inhibition of acetylcholinesterase activity in the nervous system, which is an established mode of action for chlorpyrifos neurotoxicity.	Chlorpyrifos	117-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	205-225
22036888-0	2011	Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.	Chlorpyrifos	48-60	acetylcholinesterase	Danio rerio	13-33
22036888-3	2011	We show that at non-lethal, equimolar concentrations, chlorpyrifos (CPF) is more effective at equimolar concentrations than diazinon (DZN) and parathion (PA) in producing AChE inhibition.	Chlorpyrifos	54-66	acetylcholinesterase	Danio rerio	171-175
22036888-3	2011	We show that at non-lethal, equimolar concentrations, chlorpyrifos (CPF) is more effective at equimolar concentrations than diazinon (DZN) and parathion (PA) in producing AChE inhibition.	Chlorpyrifos	68-71	acetylcholinesterase	Danio rerio	171-175
21722690-2	2011	This model was used to investigate cholinesterase inhibition from dietary exposures to an insecticide (chlorpyrifos) in populations of adults and 3 year old children.	Chlorpyrifos	103-115	butyrylcholinesterase	Homo sapiens	35-49
21521795-2	2011	Hepatic CPF cytochrome P450 desulfuration [CPF to chlorpyrifos-oxon (CPF-oxon)] and dearylation (CPF to 3,5,6-trichloro-2-pyridinol) V(max) values were 0.35 +- 0.21 and 0.73 +- 0.38 nmol   min(-1)   mg microsomal protein (-1) (mean +- S.D.	Chlorpyrifos	8-11	CD59 molecule (CD59 blood group)	Homo sapiens	189-195
21673326-2	2011	The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) plays a significant role in the detoxication of CPO, which is present in exposures and generated from chlorpyrifos (CPF) in vivo following exposure.	Chlorpyrifos	170-182	paraoxonase 1	Mus musculus	47-60
21673326-2	2011	The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) plays a significant role in the detoxication of CPO, which is present in exposures and generated from chlorpyrifos (CPF) in vivo following exposure.	Chlorpyrifos	170-182	paraoxonase 1	Mus musculus	62-66
21673326-2	2011	The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) plays a significant role in the detoxication of CPO, which is present in exposures and generated from chlorpyrifos (CPF) in vivo following exposure.	Chlorpyrifos	184-187	paraoxonase 1	Mus musculus	47-60
21673326-2	2011	The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) plays a significant role in the detoxication of CPO, which is present in exposures and generated from chlorpyrifos (CPF) in vivo following exposure.	Chlorpyrifos	184-187	paraoxonase 1	Mus musculus	62-66
21767560-5	2011	The present report summarizes our observations on plasma acetylcholinesterase activity in mice treated with chlorpyrifos, chlorpyrifos oxon, diazinon, tri-ortho-cresyl phosphate, tri-cresyl phosphate, tabun thiocholine, parathion, dichlorvos, and diisopropylfluorophosphate.	Chlorpyrifos	108-120	acetylcholinesterase	Mus musculus	57-77
21514354-6	2011	PBPK/PD model simulations estimated that a 4-fold increase or decrease in relative CYP2B6 and CYP2C19 content would produce a 9-22% inhibition in blood AChE activity following exposure of an adult to chlorpyrifos (1000 mug/kg).	Chlorpyrifos	200-212	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	83-89
21514354-6	2011	PBPK/PD model simulations estimated that a 4-fold increase or decrease in relative CYP2B6 and CYP2C19 content would produce a 9-22% inhibition in blood AChE activity following exposure of an adult to chlorpyrifos (1000 mug/kg).	Chlorpyrifos	200-212	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	94-101
21514354-2	2011	Phosphororthioate OPs like chlorpyrifos and parathion are directly activated and detoxified by various cytochrome P450s (CYPs), with the primary CYPs involved being CYP2B6 and CYP2C19.	Chlorpyrifos	27-39	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	165-171
21514354-6	2011	PBPK/PD model simulations estimated that a 4-fold increase or decrease in relative CYP2B6 and CYP2C19 content would produce a 9-22% inhibition in blood AChE activity following exposure of an adult to chlorpyrifos (1000 mug/kg).	Chlorpyrifos	200-212	acetylcholinesterase (Cartwright blood group)	Homo sapiens	152-156
21514354-2	2011	Phosphororthioate OPs like chlorpyrifos and parathion are directly activated and detoxified by various cytochrome P450s (CYPs), with the primary CYPs involved being CYP2B6 and CYP2C19.	Chlorpyrifos	27-39	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	176-183
21514354-9	2011	Changes in hepatic CYP2B6 and CYP2C19 content had more of an influence on cholinesterase inhibition for exposures to chlorpyrifos than parathion, which agrees with previously reported literature that these CYPs are more reaction biased for desulfurization (activation) and dearylation (detoxification) of chlorpyrifos compared to parathion.	Chlorpyrifos	117-129	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-25
21514354-9	2011	Changes in hepatic CYP2B6 and CYP2C19 content had more of an influence on cholinesterase inhibition for exposures to chlorpyrifos than parathion, which agrees with previously reported literature that these CYPs are more reaction biased for desulfurization (activation) and dearylation (detoxification) of chlorpyrifos compared to parathion.	Chlorpyrifos	117-129	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	30-37
21514354-9	2011	Changes in hepatic CYP2B6 and CYP2C19 content had more of an influence on cholinesterase inhibition for exposures to chlorpyrifos than parathion, which agrees with previously reported literature that these CYPs are more reaction biased for desulfurization (activation) and dearylation (detoxification) of chlorpyrifos compared to parathion.	Chlorpyrifos	305-317	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-25
21514354-9	2011	Changes in hepatic CYP2B6 and CYP2C19 content had more of an influence on cholinesterase inhibition for exposures to chlorpyrifos than parathion, which agrees with previously reported literature that these CYPs are more reaction biased for desulfurization (activation) and dearylation (detoxification) of chlorpyrifos compared to parathion.	Chlorpyrifos	305-317	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	30-37
22126615-4	2011	On the contrary, the activities of glutathione-s-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and reduced glutathione (GSH) levels were found to be significantly decreased following chlorpyrifos treatment.	Chlorpyrifos	212-224	hematopoietic prostaglandin D synthase	Rattus norvegicus	35-60
21354413-5	2011	The determination of the inhibition kinetics of pyridostigmine, malaoxon and chlorpyrifos oxon with hAChE in the presence of 5mM DEET resulted in a moderate reduction of the inhibition rate constant k(i).	Chlorpyrifos	77-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-105
21328691-0	2011	Effects of chlorpyrifos exposure on kidney Notch2-Jagged1 pathway of early prenatal embryo.	Chlorpyrifos	11-23	notch 2	Mus musculus	43-49
21328691-0	2011	Effects of chlorpyrifos exposure on kidney Notch2-Jagged1 pathway of early prenatal embryo.	Chlorpyrifos	11-23	jagged 1	Mus musculus	50-57
20692364-0	2011	Swimming impairment and acetylcholinesterase inhibition in zebrafish exposed to copper or chlorpyrifos separately, or as mixtures.	Chlorpyrifos	90-102	acetylcholinesterase	Danio rerio	24-44
21377346-0	2011	A novel, sensitive, reusable and low potential acetylcholinesterase biosensor for chlorpyrifos based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotubes gel.	Chlorpyrifos	82-94	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-67
21385392-0	2011	The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice.	Chlorpyrifos	83-95	glial fibrillary acidic protein	Mus musculus	117-148
21385392-3	2011	This study estimates changes in glial fibrillary acidic protein (GFAP) expression in hippocampal regions and correlates with histomorphometry of neurons and serum cholinesterase levels following dermal exposure to low doses of CPF with or without swim stress.	Chlorpyrifos	227-230	glial fibrillary acidic protein	Mus musculus	65-69
21385392-3	2011	This study estimates changes in glial fibrillary acidic protein (GFAP) expression in hippocampal regions and correlates with histomorphometry of neurons and serum cholinesterase levels following dermal exposure to low doses of CPF with or without swim stress.	Chlorpyrifos	227-230	butyrylcholinesterase	Mus musculus	163-177
22126615-8	2011	Moreover, zinc treatment to the chlorpyrifos-treated animals also resulted in a significant improvement in the levels of reduced glutathione, and enzyme activities of GST in both cerebrum as well as cerebellum.	Chlorpyrifos	32-44	hematopoietic prostaglandin D synthase	Rattus norvegicus	167-170
21899407-1	2011	Chlorpyrifos (CPF) is an organophosphorus insecticide, and neurotoxicity results from inhibition of acetylcholinesterase (AChE) by its metabolite, chlorpyrifos-oxon.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	100-120
21899407-1	2011	Chlorpyrifos (CPF) is an organophosphorus insecticide, and neurotoxicity results from inhibition of acetylcholinesterase (AChE) by its metabolite, chlorpyrifos-oxon.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	122-126
21899407-1	2011	Chlorpyrifos (CPF) is an organophosphorus insecticide, and neurotoxicity results from inhibition of acetylcholinesterase (AChE) by its metabolite, chlorpyrifos-oxon.	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	100-120
21899407-1	2011	Chlorpyrifos (CPF) is an organophosphorus insecticide, and neurotoxicity results from inhibition of acetylcholinesterase (AChE) by its metabolite, chlorpyrifos-oxon.	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	122-126
20211256-7	2010	Chlorpyrifos also showed a decrease in LH receptor stimulated cAMP production.	Chlorpyrifos	0-12	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	39-50
20864627-10	2010	Interestingly, we also found that xpa-1 nematodes were slightly more sensitive to chlorpyrifos than were wild type.	Chlorpyrifos	82-94	XPA_C domain-containing protein	Caenorhabditis elegans	34-39
20456333-0	2010	Time course of serum S100B protein and neuron-specific enolase levels of a single dose of chlorpyrifos in rats.	Chlorpyrifos	90-102	S100 calcium binding protein B	Rattus norvegicus	21-26
20456333-0	2010	Time course of serum S100B protein and neuron-specific enolase levels of a single dose of chlorpyrifos in rats.	Chlorpyrifos	90-102	enolase 2	Rattus norvegicus	39-62
20456333-3	2010	Effects of acute exposure to chlorpyrifos (CPF), which is a common organophosphorus pesticide used worldwide, on neuron-specific enolase (NSE) and S100B levels in rat blood during 7 days were assessed.	Chlorpyrifos	29-41	enolase 2	Rattus norvegicus	113-136
20456333-3	2010	Effects of acute exposure to chlorpyrifos (CPF), which is a common organophosphorus pesticide used worldwide, on neuron-specific enolase (NSE) and S100B levels in rat blood during 7 days were assessed.	Chlorpyrifos	29-41	enolase 2	Rattus norvegicus	138-141
20456333-3	2010	Effects of acute exposure to chlorpyrifos (CPF), which is a common organophosphorus pesticide used worldwide, on neuron-specific enolase (NSE) and S100B levels in rat blood during 7 days were assessed.	Chlorpyrifos	29-41	S100 calcium binding protein B	Rattus norvegicus	147-152
20456333-3	2010	Effects of acute exposure to chlorpyrifos (CPF), which is a common organophosphorus pesticide used worldwide, on neuron-specific enolase (NSE) and S100B levels in rat blood during 7 days were assessed.	Chlorpyrifos	43-46	enolase 2	Rattus norvegicus	113-136
20456333-3	2010	Effects of acute exposure to chlorpyrifos (CPF), which is a common organophosphorus pesticide used worldwide, on neuron-specific enolase (NSE) and S100B levels in rat blood during 7 days were assessed.	Chlorpyrifos	43-46	enolase 2	Rattus norvegicus	138-141
20456333-3	2010	Effects of acute exposure to chlorpyrifos (CPF), which is a common organophosphorus pesticide used worldwide, on neuron-specific enolase (NSE) and S100B levels in rat blood during 7 days were assessed.	Chlorpyrifos	43-46	S100 calcium binding protein B	Rattus norvegicus	147-152
20709133-6	2010	Chlorpyrifos metabolism by individual human liver microsomes was significantly correlated with CYP2B6, CYP2C19 and CYP3A4 related activity.	Chlorpyrifos	0-12	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	95-101
20709133-6	2010	Chlorpyrifos metabolism by individual human liver microsomes was significantly correlated with CYP2B6, CYP2C19 and CYP3A4 related activity.	Chlorpyrifos	0-12	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	103-110
20709133-6	2010	Chlorpyrifos metabolism by individual human liver microsomes was significantly correlated with CYP2B6, CYP2C19 and CYP3A4 related activity.	Chlorpyrifos	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	115-121
20709133-7	2010	CPO formation was best correlated with CYP2B6 related activity at low (20 muM) chlorpyrifos concentrations while CYP3A4 related activity was best correlated with CPO formation at high concentrations (100 muM) of chlorpyrifos.	Chlorpyrifos	79-91	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	39-45
20709133-7	2010	CPO formation was best correlated with CYP2B6 related activity at low (20 muM) chlorpyrifos concentrations while CYP3A4 related activity was best correlated with CPO formation at high concentrations (100 muM) of chlorpyrifos.	Chlorpyrifos	212-224	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	113-119
20709133-8	2010	TCP production was best correlated with CYP3A4 activity at all substrate concentrations of chlorpyrifos.	Chlorpyrifos	91-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46
20709133-10	2010	Calculations of percent total normalized rates (% TNR) and the chemical inhibitors ketoconazole and ticlopidine were used to confirm the importance of CYP2B6, CYP2C19, and CYP3A4 for the metabolism of chlorpyrifos.	Chlorpyrifos	201-213	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	151-157
20709133-10	2010	Calculations of percent total normalized rates (% TNR) and the chemical inhibitors ketoconazole and ticlopidine were used to confirm the importance of CYP2B6, CYP2C19, and CYP3A4 for the metabolism of chlorpyrifos.	Chlorpyrifos	201-213	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	159-166
20709133-10	2010	Calculations of percent total normalized rates (% TNR) and the chemical inhibitors ketoconazole and ticlopidine were used to confirm the importance of CYP2B6, CYP2C19, and CYP3A4 for the metabolism of chlorpyrifos.	Chlorpyrifos	201-213	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	172-178
20395308-7	2010	A fourth patient whose BChE activity was inhibited 60% by exposure to chlorpyrifos had no detectable adduct on albumin.	Chlorpyrifos	70-82	butyrylcholinesterase	Homo sapiens	23-27
20381572-3	2010	Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT), and decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in lung tissues compared to the control group.	Chlorpyrifos	0-12	catalase	Rattus norvegicus	92-100
20381572-3	2010	Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT), and decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in lung tissues compared to the control group.	Chlorpyrifos	0-12	catalase	Rattus norvegicus	102-105
20381572-3	2010	Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT), and decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in lung tissues compared to the control group.	Chlorpyrifos	0-12	hematopoietic prostaglandin D synthase	Rattus norvegicus	155-180
20381572-3	2010	Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT), and decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in lung tissues compared to the control group.	Chlorpyrifos	0-12	hematopoietic prostaglandin D synthase	Rattus norvegicus	182-185
20381572-4	2010	In the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups, there were statistically significant increases in CAT and SOD activities, while no statistically significant changes were observed in MDA, GST and GPx activities relative to the control.	Chlorpyrifos	21-33	catalase	Rattus norvegicus	133-136
20381572-4	2010	In the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups, there were statistically significant increases in CAT and SOD activities, while no statistically significant changes were observed in MDA, GST and GPx activities relative to the control.	Chlorpyrifos	54-66	catalase	Rattus norvegicus	133-136
20381572-5	2010	Compared to the chlorpyrifos-treated group, however, the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups showed significantly increased GST and GPx activity, while the activity of MDA, SOD and CAT was significantly decreased.	Chlorpyrifos	71-83	hematopoietic prostaglandin D synthase	Rattus norvegicus	163-166
20381572-5	2010	Compared to the chlorpyrifos-treated group, however, the catechin plus chlorpyrifos- and quercetin plus chlorpyrifos-treated groups showed significantly increased GST and GPx activity, while the activity of MDA, SOD and CAT was significantly decreased.	Chlorpyrifos	71-83	hematopoietic prostaglandin D synthase	Rattus norvegicus	163-166
22439320-1	2011	The aim of the study was to investigate the influence of administration of chlorpyrifos and/or enrofloxacin on the activity of chosen antioxidative enzymes i.e.: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes of rats.	Chlorpyrifos	75-87	catalase	Rattus norvegicus	190-198
22439320-1	2011	The aim of the study was to investigate the influence of administration of chlorpyrifos and/or enrofloxacin on the activity of chosen antioxidative enzymes i.e.: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes of rats.	Chlorpyrifos	75-87	catalase	Rattus norvegicus	200-203
22439320-4	2011	The four-week exposure of rats to chlorpyrifos caused noticeable decrease in SOD and CAT activity in erythrocytes of rats at the beginning of the experiment (up to 24th hour) in comparison with the control group.	Chlorpyrifos	34-46	catalase	Rattus norvegicus	85-88
20682304-3	2010	Chlorpyrifos evoked robust upregulation of cholecystokinin, corticotropin releasing hormone, galanin, neuropeptide Y, neurotensin, preproenkephalin and tachykinin 1; this involved a critical period at the commencement of neurodifferentiation, since the effects were much less notable in undifferentiated PC12 cells.	Chlorpyrifos	0-12	cholecystokinin	Rattus norvegicus	43-91
20682304-3	2010	Chlorpyrifos evoked robust upregulation of cholecystokinin, corticotropin releasing hormone, galanin, neuropeptide Y, neurotensin, preproenkephalin and tachykinin 1; this involved a critical period at the commencement of neurodifferentiation, since the effects were much less notable in undifferentiated PC12 cells.	Chlorpyrifos	0-12	neuropeptide Y	Rattus norvegicus	102-116
20682304-3	2010	Chlorpyrifos evoked robust upregulation of cholecystokinin, corticotropin releasing hormone, galanin, neuropeptide Y, neurotensin, preproenkephalin and tachykinin 1; this involved a critical period at the commencement of neurodifferentiation, since the effects were much less notable in undifferentiated PC12 cells.	Chlorpyrifos	0-12	neurotensin	Rattus norvegicus	118-129
20682304-3	2010	Chlorpyrifos evoked robust upregulation of cholecystokinin, corticotropin releasing hormone, galanin, neuropeptide Y, neurotensin, preproenkephalin and tachykinin 1; this involved a critical period at the commencement of neurodifferentiation, since the effects were much less notable in undifferentiated PC12 cells.	Chlorpyrifos	0-12	tachykinin, precursor 1	Rattus norvegicus	152-164
21170250-7	2010	There was a significant inhibition of plasma cholinesterase enzyme activity in chickens administered with chlorpyrifos compared to chickens of control group.	Chlorpyrifos	106-118	butyrylcholinesterase	Gallus gallus	45-59
19260078-5	2010	Chlorpyrifos did not lead to developmental alterations but it was found to induce the Hsp70 response as well as histopathological damages.	Chlorpyrifos	0-12	heat shock protein 8-like	Danio rerio	86-91
20097188-2	2010	Chlorpyrifos is an organophosphorus (OP) insecticide that is bioactivated to chlorpyrifos-oxon, and manifests its neurotoxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	142-162
20097188-2	2010	Chlorpyrifos is an organophosphorus (OP) insecticide that is bioactivated to chlorpyrifos-oxon, and manifests its neurotoxicity by inhibiting acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	164-168
20097188-3	2010	The objective of this study was to evaluate the impact of repeated nicotine exposure on the pharmacokinetics of chlorpyrifos (CPF) and its major metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) in blood and urine and also to determine the impact on cholinesterase (ChE) activity in plasma and brain.	Chlorpyrifos	112-124	butyrylcholinesterase	Rattus norvegicus	247-261
20097188-3	2010	The objective of this study was to evaluate the impact of repeated nicotine exposure on the pharmacokinetics of chlorpyrifos (CPF) and its major metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) in blood and urine and also to determine the impact on cholinesterase (ChE) activity in plasma and brain.	Chlorpyrifos	112-124	butyrylcholinesterase	Rattus norvegicus	263-266
20097188-3	2010	The objective of this study was to evaluate the impact of repeated nicotine exposure on the pharmacokinetics of chlorpyrifos (CPF) and its major metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) in blood and urine and also to determine the impact on cholinesterase (ChE) activity in plasma and brain.	Chlorpyrifos	126-129	butyrylcholinesterase	Rattus norvegicus	247-261
20097188-3	2010	The objective of this study was to evaluate the impact of repeated nicotine exposure on the pharmacokinetics of chlorpyrifos (CPF) and its major metabolite, 3,5,6-trichloro-2-pyridinol (TCPy) in blood and urine and also to determine the impact on cholinesterase (ChE) activity in plasma and brain.	Chlorpyrifos	126-129	butyrylcholinesterase	Rattus norvegicus	263-266
21180265-11	2010	At a higher dose (10(-3) M), pralidoxime reactivated AChE inhibited by paraoxon, chlorpyrifos, Russian VX, VX and sarin.	Chlorpyrifos	81-93	acetylcholinesterase	Rattus norvegicus	53-57
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Chlorpyrifos	182-194	paraoxonase 1	Homo sapiens	0-4
19907334-3	2010	METHODS: We examined associations between Parkinson disease and the organophosphates diazinon, chlorpyrifos, and parathion, and the influence of a functional polymorphism at position 55 in the coding region of the PON1 gene (PON1-55).	Chlorpyrifos	95-107	paraoxonase 1	Homo sapiens	214-218
19907334-7	2010	RESULTS: Carriers of the variant MM PON1-55 genotype exposed to organophosphates exhibited a greater than 2-fold increase in Parkinson disease risk compared with persons who had the wildtype or heterozygous genotype and no exposure (for diazinon, odds ratio = 2.2 [95% confidence interval = 1.1-4.5]; for chlorpyrifos, 2.6 [1.3-5.4]).	Chlorpyrifos	305-317	paraoxonase 1	Homo sapiens	36-40
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Chlorpyrifos	182-194	paraoxonase 1	Homo sapiens	86-90
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Chlorpyrifos	182-194	paraoxonase 1	Homo sapiens	86-90
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Chlorpyrifos	182-194	paraoxonase 1	Homo sapiens	86-90
19694443-6	2009	EBR had a positive effect on the activation of glutathione S-transferase (GST), peroxidase (POD), and glutathione reductase (GR) after treatment with chlorpyrifos, although the effect on GR was attenuated at later time points when plants were treated with 1 mM chlorpyrifos.	Chlorpyrifos	150-162	glutathione S-transferase	Cucumis sativus	47-72
18716607-0	2009	Cholinesterase inhibition in chlorpyrifos workers: Characterization of biomarkers of exposure and response in relation to urinary TCPy.	Chlorpyrifos	29-41	butyrylcholinesterase	Homo sapiens	0-14
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	203-215	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	203-215	butyrylcholinesterase	Homo sapiens	145-166
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	203-215	butyrylcholinesterase	Homo sapiens	168-173
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	217-220	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	217-220	butyrylcholinesterase	Homo sapiens	145-166
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	217-220	butyrylcholinesterase	Homo sapiens	168-173
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	368-371	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	368-371	butyrylcholinesterase	Homo sapiens	145-166
18716607-1	2009	The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers.	Chlorpyrifos	368-371	butyrylcholinesterase	Homo sapiens	168-173
19801823-5	2009	Carbacol and nerve growth factor (NGF), which are ERK1/2 activators, protected the neurons after CPF withdrawal, while atropine and PD98059, which are ERK1/2 inhibitors, exacerbated the cytotoxicity, indicating the involvement of inhibition of ERK1/2 phosphorylation in CPF-induced delayed cytotoxicity.	Chlorpyrifos	97-100	nerve growth factor	Rattus norvegicus	13-32
19801823-5	2009	Carbacol and nerve growth factor (NGF), which are ERK1/2 activators, protected the neurons after CPF withdrawal, while atropine and PD98059, which are ERK1/2 inhibitors, exacerbated the cytotoxicity, indicating the involvement of inhibition of ERK1/2 phosphorylation in CPF-induced delayed cytotoxicity.	Chlorpyrifos	97-100	nerve growth factor	Rattus norvegicus	34-37
19694443-8	2009	However, the expression of GST was consistently lower than that of plants treated with only chlorpyrifos.	Chlorpyrifos	92-104	glutathione S-transferase	Cucumis sativus	27-30
19694443-6	2009	EBR had a positive effect on the activation of glutathione S-transferase (GST), peroxidase (POD), and glutathione reductase (GR) after treatment with chlorpyrifos, although the effect on GR was attenuated at later time points when plants were treated with 1 mM chlorpyrifos.	Chlorpyrifos	150-162	glutathione S-transferase	Cucumis sativus	74-77
19694443-6	2009	EBR had a positive effect on the activation of glutathione S-transferase (GST), peroxidase (POD), and glutathione reductase (GR) after treatment with chlorpyrifos, although the effect on GR was attenuated at later time points when plants were treated with 1 mM chlorpyrifos.	Chlorpyrifos	150-162	peroxidase 2-like	Cucumis sativus	92-95
19159775-1	2009	This work shows the possibility of combining the high sensitivity of genetically-modified Drosophila melanogaster acetylcholinesterase (B394) with the ability of phosphotriesterase (PTE) to hydrolyse organophosphate compounds, in the aim of developing a biosensor selective to two insecticides of interest: chlorpyrifos and chlorfenvinfos.	Chlorpyrifos	307-319	Acetylcholine esterase	Drosophila melanogaster	114-134
19589100-4	2009	Results showed that chlor- pyrifos was cytotoxic at concentrations >/= 250 muM, whereas diazinon was not toxic at concentrations up to 1 mM.	Chlorpyrifos	20-34	latexin	Homo sapiens	78-81
19368821-7	2009	Our findings provide some of the first evidence for a specific mechanistic cascade contributing to the cholinesterase-independent developmental neurotoxicant actions of chlorpyrifos and its differences from diazinon, while at the same time identifying mechanistic convergence between otherwise unrelated toxicants that provides predictions about common neurodevelopmental outcomes.	Chlorpyrifos	169-181	butyrylcholinesterase	Rattus norvegicus	103-117
18996166-5	2009	Then, it was investigated if chlorpyrifos-induced cell death consisted of apoptosis, as determined by analysis of Annexin-V staining and the intracellular level of active caspase-3 by flow cytometry, and DNA fragmentation analysis.	Chlorpyrifos	29-41	annexin A5	Homo sapiens	114-123
18977431-10	2009	Interestingly, both CPS and MPT treatments caused a significant alteration in the ratio of alpha7 to alpha6 nicotinic acetylcholine receptor (nAChR) subunit expression in the substantia nigra with a non-significant elevation in alpha6 and a reduction in alpha7 at 22 days.	Chlorpyrifos	20-23	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	108-140
18977431-10	2009	Interestingly, both CPS and MPT treatments caused a significant alteration in the ratio of alpha7 to alpha6 nicotinic acetylcholine receptor (nAChR) subunit expression in the substantia nigra with a non-significant elevation in alpha6 and a reduction in alpha7 at 22 days.	Chlorpyrifos	20-23	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	142-147
18996166-5	2009	Then, it was investigated if chlorpyrifos-induced cell death consisted of apoptosis, as determined by analysis of Annexin-V staining and the intracellular level of active caspase-3 by flow cytometry, and DNA fragmentation analysis.	Chlorpyrifos	29-41	caspase 3	Homo sapiens	171-180
18996166-6	2009	It was found that chlorpyrifos induces apoptosis in Jurkat T cells in a dose- and time-dependent manner, as determined by analysis of Annexin-V staining.	Chlorpyrifos	18-30	annexin A5	Homo sapiens	134-143
18996166-8	2009	Chlorpyrifos also induced an increase in intracellular active caspase-3 in Jurkat T cells in a dose- and time-dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited chlorpyrifos-induced apoptosis.	Chlorpyrifos	0-12	caspase 3	Homo sapiens	62-71
18996166-8	2009	Chlorpyrifos also induced an increase in intracellular active caspase-3 in Jurkat T cells in a dose- and time-dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited chlorpyrifos-induced apoptosis.	Chlorpyrifos	191-203	caspase 3	Homo sapiens	134-143
18996166-9	2009	These findings indicate that chlorpyrifos can induce apoptosis in human Jurkat T cell cells, and this effect is partially mediated by the activation of intracellular caspase-3.	Chlorpyrifos	29-41	caspase 3	Homo sapiens	166-175
18703558-0	2008	Effect of different administration paradigms on cholinesterase inhibition following repeated chlorpyrifos exposure in late preweanling rats.	Chlorpyrifos	93-105	butyrylcholinesterase	Rattus norvegicus	48-62
18832183-8	2009	Our data demonstrates that several pesticides and plasticizers, including diethylhexylphthalate, nonylphenol, cypermethrin, and chlorpyrifos activate CAR.	Chlorpyrifos	128-140	nuclear receptor subfamily 1 group I member 3	Homo sapiens	150-153
18617161-1	2008	Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8).	Chlorpyrifos	34-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	226-251
18617161-1	2008	Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8).	Chlorpyrifos	34-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	253-257
18617161-1	2008	Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8).	Chlorpyrifos	34-46	butyrylcholinesterase	Homo sapiens	275-296
18617161-1	2008	Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8).	Chlorpyrifos	34-46	butyrylcholinesterase	Homo sapiens	298-303
18266068-1	2008	The aim of this work was to study the pharmacokinetic behaviour and the inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities of chlorpyrifos in male and female cattle after pour-on administration.	Chlorpyrifos	154-166	acetylcholinesterase	Bos taurus	93-113
18576221-0	2008	Use of cholinesterase activity in monitoring chlorpyrifos exposure of steer cattle after topical administration.	Chlorpyrifos	45-57	butyrylcholinesterase	Bos taurus	7-21
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	167-179	acetylcholinesterase	Bos taurus	92-112
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	167-179	acetylcholinesterase	Bos taurus	114-118
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	167-179	butyrylcholinesterase	Bos taurus	124-145
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	167-179	butyrylcholinesterase	Bos taurus	147-151
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	181-184	acetylcholinesterase	Bos taurus	92-112
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	181-184	acetylcholinesterase	Bos taurus	114-118
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	181-184	butyrylcholinesterase	Bos taurus	124-145
18576221-1	2008	The aim of this work was to study the pharmacokinetic behavior and the inhibitory effect of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities of chlorpyrifos (CPF) in steer cattle after pour-on administration.	Chlorpyrifos	181-184	butyrylcholinesterase	Bos taurus	147-151
18322939-6	2008	The insecticides chlorpyrifos, carbaryl, carbofuran and fipronil, as well as the repellant DEET, are all extensively metabolized by human liver microsomes and, although a number of CYP isoforms may be involved, CYP2B6 and CYP3A4 are usually the most important.	Chlorpyrifos	17-29	peptidylprolyl isomerase G	Homo sapiens	181-184
18322939-9	2008	Chlorpyrifos and other phosphorothioates are potent inhibitors of the CYP-dependent metabolism of both endogenous substrates, such as testosterone and estradiol, and exogenous substrates, such as carbaryl, presumably as a result of the interaction of highly reactive sulfur, released during the oxidative desulfuration reaction, with the heme iron of CYP.	Chlorpyrifos	0-12	peptidylprolyl isomerase G	Homo sapiens	70-73
18322939-9	2008	Chlorpyrifos and other phosphorothioates are potent inhibitors of the CYP-dependent metabolism of both endogenous substrates, such as testosterone and estradiol, and exogenous substrates, such as carbaryl, presumably as a result of the interaction of highly reactive sulfur, released during the oxidative desulfuration reaction, with the heme iron of CYP.	Chlorpyrifos	0-12	peptidylprolyl isomerase G	Homo sapiens	351-354
18502319-6	2008	Chlorpyrifos and diazinon both had widespread effects on the fgf, ntf, wnt and fzd families but much less on the bdnf and ngf groups.	Chlorpyrifos	0-12	Wnt family member 2	Rattus norvegicus	71-74
18502319-6	2008	Chlorpyrifos and diazinon both had widespread effects on the fgf, ntf, wnt and fzd families but much less on the bdnf and ngf groups.	Chlorpyrifos	0-12	brain-derived neurotrophic factor	Rattus norvegicus	113-117
18502319-6	2008	Chlorpyrifos and diazinon both had widespread effects on the fgf, ntf, wnt and fzd families but much less on the bdnf and ngf groups.	Chlorpyrifos	0-12	nerve growth factor	Rattus norvegicus	122-125
18375477-7	2008	RESULTS: The usefulness of a plasma BuChE activity <600 mU/ml on admission varied markedly--while highly sensitive in chlorpyrifos poisoning (sensitivity 11/11 deaths; 100%, 95% CI 71.5-100), its specificity was only 17.7% (12.6-23.7).	Chlorpyrifos	121-133	butyrylcholinesterase	Homo sapiens	36-41
18266068-6	2008	The inhibitory effect of topical chlorpyrifos administration was lower on butyrylcholinesterase than on acetylcholinesterase.	Chlorpyrifos	33-45	acetylcholinesterase	Bos taurus	104-124
18076960-0	2008	Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase.	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-125
18394709-0	2008	Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat.	Chlorpyrifos	158-170	butyrylcholinesterase	Rattus norvegicus	108-122
18222074-2	2008	Cell apoptosis, lipid peroxidation and DNA damage were increased, and activities of antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase were decreased in retina of chlorpyrifos-administrated mice (63mg/kg, single treatment, via oral gavage).	Chlorpyrifos	190-202	catalase	Mus musculus	126-134
18355640-5	2008	This pattern differed substantially from that seen in earlier work with another organophosphate, chlorpyrifos, which at pharmacodynamically similar doses spanning the threshold for cholinesterase inhibition, evoked a much more substantial, global upregulation of 5HT receptor expression; with chlorpyrifos, effects on receptors were seen in females, albeit to a lesser extent than in males, and were also regionally distinct.	Chlorpyrifos	97-109	butyrylcholinesterase	Rattus norvegicus	181-195
18155347-5	2008	Chlorpyrifos-induced toxicity was characterized by the loss of mitochondrial potential, the appearance of nuclear condensation and fragmentation, down-regulation of Bcl-2 as well as up-regulation of TNFalpha and FAS mRNA.	Chlorpyrifos	0-12	BCL2 apoptosis regulator	Homo sapiens	165-170
18155347-5	2008	Chlorpyrifos-induced toxicity was characterized by the loss of mitochondrial potential, the appearance of nuclear condensation and fragmentation, down-regulation of Bcl-2 as well as up-regulation of TNFalpha and FAS mRNA.	Chlorpyrifos	0-12	tumor necrosis factor	Homo sapiens	199-207
18155347-10	2008	Taken collectively, these results suggest that chlorpyrifos induces apoptosis in placental cells through pathways not dependent on FAS/TNF signaling, activation of caspases or inhibition of cholinesterase.	Chlorpyrifos	47-59	butyrylcholinesterase	Homo sapiens	190-204
18158111-1	2008	Developmental exposure to the organophosphorus pesticides chlorpyrifos and diazinon (DZN) alters serotonergic synaptic function at doses below the threshold for cholinesterase inhibition, however there are some indications that the two agents may differ in several important attributes.	Chlorpyrifos	58-70	butyrylcholinesterase	Rattus norvegicus	161-175
18371683-0	2008	An optical fiber biosensor for chlorpyrifos using a single sol-gel film containing acetylcholinesterase and bromothymol blue.	Chlorpyrifos	31-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-103
18371683-1	2008	An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos.	Chlorpyrifos	164-176	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-61
18371683-1	2008	An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos.	Chlorpyrifos	164-176	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-67
18371683-9	2008	A linear calibration curve of chlorpyrifos against the percentage inhibition of AChE was obtained from 0.05 to 2.0mg/L of chlorpyrifos (18-80% inhibition, R(2)=0.9869, n=6).	Chlorpyrifos	30-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
18371683-9	2008	A linear calibration curve of chlorpyrifos against the percentage inhibition of AChE was obtained from 0.05 to 2.0mg/L of chlorpyrifos (18-80% inhibition, R(2)=0.9869, n=6).	Chlorpyrifos	122-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
17666426-6	2007	Reduction of ChE activity and mAChR binding by CPS or MPS was more evident in rats at PND8 than at PND4.	Chlorpyrifos	47-50	butyrylcholinesterase	Rattus norvegicus	13-16
18800293-4	2008	The active metabolite of the organophosphorus insecticide chlorpyrifos, i.e., chlorpyrifos oxon (CPO), inhibited agonist-induced phosphorylation of human recombinant M2 receptors by GRK2 in vitro in a concentration-dependent manner.	Chlorpyrifos	58-70	G protein-coupled receptor kinase 2	Homo sapiens	182-186
17928175-2	2007	Chlorpyrifos was acutely administered taking into account cholinesterase inhibition and determination of the acute (24h) median lethal dose (LD50).	Chlorpyrifos	0-12	butyrylcholinesterase	Gallus gallus	58-72
17928175-4	2007	Chlorpyrifos at the dose rates of 5,10 and 20mg/kg orally produced within 2h signs of cholinergic toxicosis in the chicks and significantly inhibited plasma (40-70%), whole brain (43-69%) and liver (31-46%) cholinesterase activities in a dose-dependent manner.	Chlorpyrifos	0-12	butyrylcholinesterase	Gallus gallus	207-221
17928175-7	2007	Only the high dose of chlorpyrifos (4mg/kg, orally) given repeatedly for 7 days caused significant cholinesterase inhibition in the whole brain (37%) and the liver (22%).	Chlorpyrifos	22-34	butyrylcholinesterase	Gallus gallus	99-113
18726789-3	2008	Current "background" (nonoccupational) levels of exposure to chlorpyrifos are several orders of magnitude lower than those required to inhibit plasma cholinesterase activity, which is a more sensitive target than nervous system cholinesterase.	Chlorpyrifos	61-73	butyrylcholinesterase	Homo sapiens	150-164
19326769-3	2008	The present study was designed to examine chlorpyrifos and DEET mediated induction of CYP isoforms and also to characterize their potential cytotoxic effects on primary human hepatocytes.	Chlorpyrifos	42-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	86-89
19326769-4	2008	DEET significantly induced CYP3A4, CYP2B6, CYP2A6 and CYP1A2 mRNA expression while chlorpyrifos induced CYP1A1, CYP1A2 and CYP3A4 mRNA, and to a lesser extent, CYP1B1 and CYP2B6 mRNA in primary human hepatocytes.	Chlorpyrifos	83-95	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	104-110
19326769-4	2008	DEET significantly induced CYP3A4, CYP2B6, CYP2A6 and CYP1A2 mRNA expression while chlorpyrifos induced CYP1A1, CYP1A2 and CYP3A4 mRNA, and to a lesser extent, CYP1B1 and CYP2B6 mRNA in primary human hepatocytes.	Chlorpyrifos	83-95	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	112-118
19326769-4	2008	DEET significantly induced CYP3A4, CYP2B6, CYP2A6 and CYP1A2 mRNA expression while chlorpyrifos induced CYP1A1, CYP1A2 and CYP3A4 mRNA, and to a lesser extent, CYP1B1 and CYP2B6 mRNA in primary human hepatocytes.	Chlorpyrifos	83-95	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	123-129
19326769-4	2008	DEET significantly induced CYP3A4, CYP2B6, CYP2A6 and CYP1A2 mRNA expression while chlorpyrifos induced CYP1A1, CYP1A2 and CYP3A4 mRNA, and to a lesser extent, CYP1B1 and CYP2B6 mRNA in primary human hepatocytes.	Chlorpyrifos	83-95	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	160-166
19326769-4	2008	DEET significantly induced CYP3A4, CYP2B6, CYP2A6 and CYP1A2 mRNA expression while chlorpyrifos induced CYP1A1, CYP1A2 and CYP3A4 mRNA, and to a lesser extent, CYP1B1 and CYP2B6 mRNA in primary human hepatocytes.	Chlorpyrifos	83-95	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	171-177
19326769-5	2008	Chlorpyrifos and DEET also mediated the expression of CYP isoforms, particularly CYP3A4, CYP2B6 and CYP1A1, as shown by CYP3A4-specific protein expression, testosterone metabolism and CYP1Al-specific activity assays.	Chlorpyrifos	0-12	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	54-57
19326769-5	2008	Chlorpyrifos and DEET also mediated the expression of CYP isoforms, particularly CYP3A4, CYP2B6 and CYP1A1, as shown by CYP3A4-specific protein expression, testosterone metabolism and CYP1Al-specific activity assays.	Chlorpyrifos	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
19326769-5	2008	Chlorpyrifos and DEET also mediated the expression of CYP isoforms, particularly CYP3A4, CYP2B6 and CYP1A1, as shown by CYP3A4-specific protein expression, testosterone metabolism and CYP1Al-specific activity assays.	Chlorpyrifos	0-12	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	89-95
19326769-5	2008	Chlorpyrifos and DEET also mediated the expression of CYP isoforms, particularly CYP3A4, CYP2B6 and CYP1A1, as shown by CYP3A4-specific protein expression, testosterone metabolism and CYP1Al-specific activity assays.	Chlorpyrifos	0-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106
19326769-5	2008	Chlorpyrifos and DEET also mediated the expression of CYP isoforms, particularly CYP3A4, CYP2B6 and CYP1A1, as shown by CYP3A4-specific protein expression, testosterone metabolism and CYP1Al-specific activity assays.	Chlorpyrifos	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	120-126
19326769-6	2008	DEET is a mild, while chlorpyrifos is a relatively potent, inducer of adenylate kinase and caspase-3/7, an indicator of apoptosis, while inducing 15-20% and 25-30% cell death, respectively.	Chlorpyrifos	22-34	caspase 3	Homo sapiens	91-102
19326769-7	2008	Therefore, DEET and chlorpyrifos mediated induction of CYP mRNA and functional CYP isoforms together with their cytotoxic potential in human hepatocytes suggests that exposure to chlorpyrifos and/or DEET should be considered in human health impact analysis.	Chlorpyrifos	20-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	55-58
19326769-7	2008	Therefore, DEET and chlorpyrifos mediated induction of CYP mRNA and functional CYP isoforms together with their cytotoxic potential in human hepatocytes suggests that exposure to chlorpyrifos and/or DEET should be considered in human health impact analysis.	Chlorpyrifos	20-32	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-82
19326769-7	2008	Therefore, DEET and chlorpyrifos mediated induction of CYP mRNA and functional CYP isoforms together with their cytotoxic potential in human hepatocytes suggests that exposure to chlorpyrifos and/or DEET should be considered in human health impact analysis.	Chlorpyrifos	179-191	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	55-58
19326769-7	2008	Therefore, DEET and chlorpyrifos mediated induction of CYP mRNA and functional CYP isoforms together with their cytotoxic potential in human hepatocytes suggests that exposure to chlorpyrifos and/or DEET should be considered in human health impact analysis.	Chlorpyrifos	179-191	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-82
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	19-31	nerve growth factor	Rattus norvegicus	219-238
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	19-31	nerve growth factor	Rattus norvegicus	240-243
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	19-31	brain-derived neurotrophic factor	Rattus norvegicus	249-282
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	19-31	brain-derived neurotrophic factor	Rattus norvegicus	284-288
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	33-36	nerve growth factor	Rattus norvegicus	219-238
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	33-36	nerve growth factor	Rattus norvegicus	240-243
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	33-36	brain-derived neurotrophic factor	Rattus norvegicus	249-282
17893397-1	2007	Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).	Chlorpyrifos	33-36	brain-derived neurotrophic factor	Rattus norvegicus	284-288
17893397-2	2007	The effects of postnatal exposure to CPS and MPS on the expression of messenger RNA (mRNA) and protein levels for NGF and BDNF were investigated in the frontal cerebral cortex (cortex) and hippocampus of rats.	Chlorpyrifos	37-40	nerve growth factor	Rattus norvegicus	114-117
17893397-2	2007	The effects of postnatal exposure to CPS and MPS on the expression of messenger RNA (mRNA) and protein levels for NGF and BDNF were investigated in the frontal cerebral cortex (cortex) and hippocampus of rats.	Chlorpyrifos	37-40	brain-derived neurotrophic factor	Rattus norvegicus	122-126
17618723-9	2007	The study suggests that (i) dichlorvos is more deleterious to fly reproduction compared to chlorpyrifos with an adverse effect on Acp70A and Acp36DE expression required to facilitate normal reproduction; (ii) hsp70 may be used as a marker of cellular damage against dichlorvos and chlorpyrifos in Drosophila.	Chlorpyrifos	281-293	Heat-shock-protein-70Ab	Drosophila melanogaster	209-214
17697042-12	2007	However, magnitudes of affinity are similar, and minnow SERT binding is decreased by chronic sertraline or chlorpyrifos administration.	Chlorpyrifos	107-119	solute carrier family 6 member 4	Rattus norvegicus	56-60
17644233-0	2007	Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart.	Chlorpyrifos	28-40	butyrylcholinesterase	Rattus norvegicus	53-67
17644233-10	2007	In vitro inhibition studies indicated that ChE in neonatal tissues was markedly more sensitive to inhibition by the active metabolite of chlorpyrifos (i.e., chlorpyrifos oxon, CPO) than enzyme in adult tissues (IC(50) values: neonates, 17 nM; adults, 200 nM).	Chlorpyrifos	137-149	butyrylcholinesterase	Rattus norvegicus	43-46
17194517-11	2007	AChE-/- mice treated with chlorpyrifos oxon lost all BChE activity, had severe cholinergic symptoms and died of convulsions.	Chlorpyrifos	26-38	acetylcholinesterase	Mus musculus	0-4
16753212-0	2007	Body size-related differences in the inhibition of brain acetylcholinesterase activity in juvenile Nile tilapia (Oreochromis niloticus) by chlorpyrifos and carbosulfan.	Chlorpyrifos	139-151	acetylcholinesterase	Oreochromis niloticus	57-77
16753212-1	2007	Influence of body size on inhibition of brain acetylcholinesterase (AChE) activity of juvenile Nile tilapia, Oreochromis niloticus by chlorpyrifos and carbosulfan was investigated concerning its potential use in the biomonitoring of anticholinesterase pesticides in tropical water bodies.	Chlorpyrifos	134-146	acetylcholinesterase	Oreochromis niloticus	46-66
16753212-1	2007	Influence of body size on inhibition of brain acetylcholinesterase (AChE) activity of juvenile Nile tilapia, Oreochromis niloticus by chlorpyrifos and carbosulfan was investigated concerning its potential use in the biomonitoring of anticholinesterase pesticides in tropical water bodies.	Chlorpyrifos	134-146	acetylcholinesterase	Oreochromis niloticus	68-72
17538235-12	2007	There was a significant increase in PCV, RBC, Hb, TP and creatinine, but a significant decrease was obtained in WBC, ALT and AST in the CPF-treated group compared to the control.	Chlorpyrifos	136-139	glutamic pyruvic transaminase, soluble	Mus musculus	117-120
17538235-12	2007	There was a significant increase in PCV, RBC, Hb, TP and creatinine, but a significant decrease was obtained in WBC, ALT and AST in the CPF-treated group compared to the control.	Chlorpyrifos	136-139	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	125-128
17538235-13	2007	All the parameters with the exception of WBC, ALT and AST (which increased significantly), were significantly decreased in the vitamin C + CPF-treated group compared to CPF-treated group.	Chlorpyrifos	139-142	glutamic pyruvic transaminase, soluble	Mus musculus	46-49
17538235-13	2007	All the parameters with the exception of WBC, ALT and AST (which increased significantly), were significantly decreased in the vitamin C + CPF-treated group compared to CPF-treated group.	Chlorpyrifos	139-142	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	54-57
17589599-4	2007	RESULTS: Chlorpyrifos and diazinon both markedly suppressed fgf20 expression in the forebrain and fgf2 in the brain stem, while elevating brain stem fgfr4 and evoking a small deficit in brain stem fgf22.	Chlorpyrifos	9-21	fibroblast growth factor 20	Rattus norvegicus	60-65
17589599-4	2007	RESULTS: Chlorpyrifos and diazinon both markedly suppressed fgf20 expression in the forebrain and fgf2 in the brain stem, while elevating brain stem fgfr4 and evoking a small deficit in brain stem fgf22.	Chlorpyrifos	9-21	fibroblast growth factor 2	Rattus norvegicus	60-64
17589599-4	2007	RESULTS: Chlorpyrifos and diazinon both markedly suppressed fgf20 expression in the forebrain and fgf2 in the brain stem, while elevating brain stem fgfr4 and evoking a small deficit in brain stem fgf22.	Chlorpyrifos	9-21	fibroblast growth factor receptor 4	Rattus norvegicus	149-154
17589599-4	2007	RESULTS: Chlorpyrifos and diazinon both markedly suppressed fgf20 expression in the forebrain and fgf2 in the brain stem, while elevating brain stem fgfr4 and evoking a small deficit in brain stem fgf22.	Chlorpyrifos	9-21	fibroblast growth factor 22	Rattus norvegicus	197-202
17382447-0	2007	Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice.	Chlorpyrifos	91-103	butyrylcholinesterase	Mus musculus	0-14
17350100-2	2007	For this, the study was divided in two phases; in the first phase, we studied the time course of the effects produced by treatment with a high dose of CPF (250 mg/kg s.c.) on rat locomotor activity and anxiety behaviours recorded on an open-field, as well as on AChE inhibition.	Chlorpyrifos	151-154	acetylcholinesterase	Rattus norvegicus	262-266
17194517-11	2007	AChE-/- mice treated with chlorpyrifos oxon lost all BChE activity, had severe cholinergic symptoms and died of convulsions.	Chlorpyrifos	26-38	butyrylcholinesterase	Mus musculus	53-57
17141929-1	2007	Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide.	Chlorpyrifos	164-176	acetylcholinesterase	Canis lupus familiaris	82-102
17141929-1	2007	Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide.	Chlorpyrifos	164-176	acetylcholinesterase	Canis lupus familiaris	104-108
17141929-1	2007	Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide.	Chlorpyrifos	164-176	acetylcholinesterase	Canis lupus familiaris	141-145
17141929-1	2007	Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide.	Chlorpyrifos	178-181	acetylcholinesterase	Canis lupus familiaris	82-102
17141929-1	2007	Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide.	Chlorpyrifos	178-181	acetylcholinesterase	Canis lupus familiaris	104-108
17141929-1	2007	Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide.	Chlorpyrifos	178-181	acetylcholinesterase	Canis lupus familiaris	141-145
17194553-8	2007	Similarly, co-administration of zinc to chlorpyrifos intoxicated animals normalized the enzymatic activities of cytochrome P(450), NADPH cytochrome-c-reductase and NADH cytochrome-c-reductase within normal range.	Chlorpyrifos	40-52	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	112-129
18072155-17	2007	Using the modified electrometric method, various percentages of cholinesterase inhibitions in the plasma, erythrocytes, and whole blood were detected after in vitro addition of the organophosphate insecticides (chlorpyrifos and methidathion) and the carbamate insecticide (carbaryl) to the reaction mixtures.	Chlorpyrifos	211-223	butyrylcholinesterase	Homo sapiens	64-78
17366821-0	2007	Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.	Chlorpyrifos	119-131	acetylcholinesterase	Rattus norvegicus	26-46
17079358-0	2007	Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.	Chlorpyrifos	67-79	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	25-29
17079358-5	2007	CYP1A2, 2B6, 2C9, 2C19, 3A4, 3A5, and 3A7 were found to be active to a widely varying degree in parathion metabolism, whereas all, with the exception of CYP2C9, were also found to be active in chlorpyrifos metabolism.	Chlorpyrifos	193-205	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-6
18254274-0	2007	Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).	Chlorpyrifos	162-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-136
18254274-5	2007	In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used.	Chlorpyrifos	165-177	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-38
18254274-5	2007	In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used.	Chlorpyrifos	165-177	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135
20020880-0	2007	The evaluation of altered antioxidative defense mechanism and acetylcholinesterase activity in rat brain exposed to chlorpyrifos, deltamethrin, and their combination.	Chlorpyrifos	116-128	acetylcholinesterase	Rattus norvegicus	62-82
17365099-0	2007	Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats.	Chlorpyrifos	0-12	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	72-76
17365099-0	2007	Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats.	Chlorpyrifos	0-12	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	81-85
17365099-1	2007	The present study investigated the effect of chlorpyrifos on NMDA receptor subunits NR2A and NR2B in juvenile and adult rats.	Chlorpyrifos	45-57	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	84-88
17365099-3	2007	Chlorpyrifos significantly inhibited the AChE activity in juvenile and adult rats (p < .05).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	41-45
17365099-4	2007	NR2A and NR2B levels significantly increased in juvenile and adult rats by chlorpyrifos application (p < .05).	Chlorpyrifos	75-87	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	0-4
17365099-4	2007	NR2A and NR2B levels significantly increased in juvenile and adult rats by chlorpyrifos application (p < .05).	Chlorpyrifos	75-87	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	9-13
17936932-6	2007	A number of pesticides, including chlorpyrifos, fipronil and permethrin, and the repellent, DEET, have been shown to be inducers of CYP isoforms in human hepatocytes, with fipronil being the most potent.	Chlorpyrifos	34-46	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	132-135
17936934-4	2007	The detoxication of the oxon forms of diazinon and chlorpyrifos is achieved by hydrolysis to the respective aromatic alcohols and diethyl phosphates primarily by paraoxonase 1 (PON1), a plasma enzyme tightly associated with high-density lipoprotein particles and also found in liver.	Chlorpyrifos	51-63	paraoxonase 1	Mus musculus	162-175
17936934-4	2007	The detoxication of the oxon forms of diazinon and chlorpyrifos is achieved by hydrolysis to the respective aromatic alcohols and diethyl phosphates primarily by paraoxonase 1 (PON1), a plasma enzyme tightly associated with high-density lipoprotein particles and also found in liver.	Chlorpyrifos	51-63	paraoxonase 1	Mus musculus	177-181
17427179-0	2007	Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos.	Chlorpyrifos	109-121	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	81-96
17427179-1	2007	Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms.	Chlorpyrifos	39-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	151-166
17427179-1	2007	Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms.	Chlorpyrifos	39-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	168-171
17427179-1	2007	Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms.	Chlorpyrifos	53-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	151-166
17427179-1	2007	Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms.	Chlorpyrifos	53-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	168-171
17427179-5	2007	CPS significantly inhibited the metabolism of fipronil by CYP3A4 as well as the metabolism of nonane by CYP2B6.	Chlorpyrifos	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-64
17427179-5	2007	CPS significantly inhibited the metabolism of fipronil by CYP3A4 as well as the metabolism of nonane by CYP2B6.	Chlorpyrifos	0-3	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	104-110
20020880-3	2007	Biochemical analysis showed that administration of chlorpyrifos and deltamethrin causes brain damage via production of MDA and inhibition of AChE.	Chlorpyrifos	51-63	acetylcholinesterase	Rattus norvegicus	141-145
16777161-1	2006	This study examined the acute effects of chlorpyrifos (CPF) on cholinesterase inhibition and acetylcholine levels in the striatum of freely moving rats using in vivo microdialysis.	Chlorpyrifos	55-58	butyrylcholinesterase	Rattus norvegicus	63-77
17110060-2	2006	Since OPT-induced neurodevelopmental effects may be due to in situ bioactivation by foetal enzymes, the catalytic activity of the foetal CYP3A7 toward chlorpyrifos (CPF), parathion (PAR), malathion (MAL) and fenthion (FEN) has been assessed by using recombinant enzymes.	Chlorpyrifos	151-163	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	137-143
17265677-0	2006	Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase.	Chlorpyrifos	69-81	acetylcholinesterase	Rattus norvegicus	93-113
17265677-7	2006	In case of chlorpyrifos, TO231 was the most potent AChE reactivator with an 82 % reactivation at 1.0 mmol L(-1) oxime concentration.	Chlorpyrifos	11-23	acetylcholinesterase	Rattus norvegicus	51-55
17016712-12	2006	DISCUSSION: Taken together, our data confirm and extend the long-term behavioral effects of subcutaneous administration of CPF and point to a role for other systems that, besides AChE inhibition, contribute to the long-term neurotoxicity of CPF.	Chlorpyrifos	123-126	acetylcholinesterase	Rattus norvegicus	179-183
16838488-0	2006	[Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos].	Chlorpyrifos	201-213	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-65
16871525-0	2006	Expression of Th1/Th2 cytokines in human blood after in vitro treatment with chlorpyrifos, and its metabolites, in combination with endotoxin LPS and allergen Der p1.	Chlorpyrifos	77-89	negative elongation factor complex member C/D	Homo sapiens	14-17
16790487-9	2006	Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation.	Chlorpyrifos	72-84	interferon gamma	Homo sapiens	119-135
16790487-9	2006	Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation.	Chlorpyrifos	72-84	insulin	Homo sapiens	140-147
16790487-9	2006	Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation.	Chlorpyrifos	72-84	mitogen-activated protein kinase 3	Homo sapiens	222-263
16790487-9	2006	Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation.	Chlorpyrifos	72-84	insulin	Homo sapiens	284-291
16790487-9	2006	Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation.	Chlorpyrifos	72-84	interleukin 6	Homo sapiens	303-316
16787693-3	2006	Then, we investigated if chlorpyrifos-induced cell death consisted of apoptosis, as determined by analysis of Annexin-V staining and the intracellular level of active caspase-3 by flow cytometry, and DNA fragmentation analysis.	Chlorpyrifos	25-37	annexin A5	Homo sapiens	110-119
16787693-3	2006	Then, we investigated if chlorpyrifos-induced cell death consisted of apoptosis, as determined by analysis of Annexin-V staining and the intracellular level of active caspase-3 by flow cytometry, and DNA fragmentation analysis.	Chlorpyrifos	25-37	caspase 3	Homo sapiens	167-176
16787693-4	2006	We found that chlorpyrifos induced apoptosis in U937 in a time- and dose-dependent manner, as shown by Annexin-V staining.	Chlorpyrifos	14-26	annexin A5	Homo sapiens	103-112
16787693-6	2006	Chlorpyrifos also induced an increase of intracellular active caspase-3 in U937 cells in a dose-dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited the chlorpyrifos-induced apoptosis.	Chlorpyrifos	0-12	caspase 3	Homo sapiens	62-71
16787693-6	2006	Chlorpyrifos also induced an increase of intracellular active caspase-3 in U937 cells in a dose-dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited the chlorpyrifos-induced apoptosis.	Chlorpyrifos	181-193	caspase 3	Homo sapiens	62-71
16787693-6	2006	Chlorpyrifos also induced an increase of intracellular active caspase-3 in U937 cells in a dose-dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited the chlorpyrifos-induced apoptosis.	Chlorpyrifos	181-193	caspase 3	Homo sapiens	120-129
16787693-7	2006	These findings indicate that chlorpyrifos can induce apoptosis in U937 cells, and this effect is partially mediated by activation of intracellular caspase-3.	Chlorpyrifos	29-41	caspase 3	Homo sapiens	147-156
16482470-8	2006	Female offspring from mothers treated with a combination of nicotine and chlorpyrifos showed significant increase in plasma BChE activity.	Chlorpyrifos	73-85	butyrylcholinesterase	Rattus norvegicus	124-128
16482470-10	2006	Brainstem and cerebellum of female offspring from mothers treated with nicotine or chlorpyrifos, alone or in combination showed increased AChE activity, whereas brainstem of male offspring from mothers treated with nicotine alone or a combination of nicotine and chlorpyrifos showed increase in AChE activity.	Chlorpyrifos	83-95	acetylcholinesterase	Rattus norvegicus	138-142
16482470-10	2006	Brainstem and cerebellum of female offspring from mothers treated with nicotine or chlorpyrifos, alone or in combination showed increased AChE activity, whereas brainstem of male offspring from mothers treated with nicotine alone or a combination of nicotine and chlorpyrifos showed increase in AChE activity.	Chlorpyrifos	83-95	acetylcholinesterase	Rattus norvegicus	295-299
16482470-14	2006	These results indicate that in utero exposure to nicotine and chlorpyrifos, alone and in combination produced significant sensorimotor deficits in male and female offspring, differential increase in brain AChE activity, a decrease in the surviving neurons and an increased expression of GFAP in cerebellum in adult offspring rats at a corresponding human adult age.	Chlorpyrifos	62-74	acetylcholinesterase	Rattus norvegicus	205-209
16482470-14	2006	These results indicate that in utero exposure to nicotine and chlorpyrifos, alone and in combination produced significant sensorimotor deficits in male and female offspring, differential increase in brain AChE activity, a decrease in the surviving neurons and an increased expression of GFAP in cerebellum in adult offspring rats at a corresponding human adult age.	Chlorpyrifos	62-74	glial fibrillary acidic protein	Rattus norvegicus	287-291
16790556-11	2006	Preincubation of CYP1A2 with chlorpyrifos, fonofos, carbaryl, or naphthalene resulted in 96, 59, 84, and 87% inhibition of E2 metabolism, respectively.	Chlorpyrifos	29-41	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	17-23
16790556-12	2006	Preincubation of CYP3A4 with chlorpyrifos, fonofos, deltamethrin, or permethrin resulted in 94, 87, 58, and 37% inhibition of E2 metabolism.	Chlorpyrifos	29-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	17-23
16675515-2	2006	The effects of postnatal exposure to CPS on the expression of mRNA for two factors critical to brain development, nerve growth factor (NGF) and reelin, were investigated in the forebrain of rats.	Chlorpyrifos	37-40	nerve growth factor	Rattus norvegicus	114-133
16675515-8	2006	The expression of NGF, reelin, and M(1) mAChR mRNA was significantly reduced with both dosages of CPS in both sexes.	Chlorpyrifos	98-101	nerve growth factor	Rattus norvegicus	18-21
16675515-9	2006	beta-III Tubulin mRNA expression remained unchanged after exposure, whereas MAG mRNA expression was significantly decreased with both dosages of CPS in both sexes, suggesting effects on the developing oligodendrocytes.	Chlorpyrifos	145-148	myelin-associated glycoprotein	Rattus norvegicus	76-79
16675515-10	2006	In contrast, GFAP mRNA levels were significantly increased with both dosages of CPS in both sexes, suggesting increased astrocyte reactivity.	Chlorpyrifos	80-83	glial fibrillary acidic protein	Rattus norvegicus	13-17
15991261-3	2006	Administering a combination dose of chlorpyriphos and cypermethrin (20 mg kg(-1) each) on alternate days over a 15-day period to male mice resulted in induction of sub-acute toxicity as reflected by elevated levels of liver damage marker enzymes alkaline phosphatase(ALP), aspartate transaminase(AST) and alanine transaminase(ALT).	Chlorpyrifos	36-49	alopecia, recessive	Mus musculus	267-270
15991261-3	2006	Administering a combination dose of chlorpyriphos and cypermethrin (20 mg kg(-1) each) on alternate days over a 15-day period to male mice resulted in induction of sub-acute toxicity as reflected by elevated levels of liver damage marker enzymes alkaline phosphatase(ALP), aspartate transaminase(AST) and alanine transaminase(ALT).	Chlorpyrifos	36-49	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	296-299
15991261-3	2006	Administering a combination dose of chlorpyriphos and cypermethrin (20 mg kg(-1) each) on alternate days over a 15-day period to male mice resulted in induction of sub-acute toxicity as reflected by elevated levels of liver damage marker enzymes alkaline phosphatase(ALP), aspartate transaminase(AST) and alanine transaminase(ALT).	Chlorpyrifos	36-49	glutamic pyruvic transaminase, soluble	Mus musculus	326-329
17044511-4	2006	Water quality also had a significant effect, with a decreasing degradation rate of chlorpyrifos in the sequence of distilled water > tap water > river water > lake wate > paddy water.	Chlorpyrifos	83-95	nuclear RNA export factor 1	Homo sapiens	136-139
16378699-5	2006	Chlorpyrifos intoxication resulted in a significant increase in the activities of glucose-6-phosphatase and glycogen phosphorylase, whereas, it caused a significant inhibition in the levels of hexokinase, SDH, LDH and glycogen content.	Chlorpyrifos	0-12	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	82-103
16378699-5	2006	Chlorpyrifos intoxication resulted in a significant increase in the activities of glucose-6-phosphatase and glycogen phosphorylase, whereas, it caused a significant inhibition in the levels of hexokinase, SDH, LDH and glycogen content.	Chlorpyrifos	0-12	glycogen phosphorylase L	Rattus norvegicus	108-130
16824341-3	2006	In vitro experiments, the purified mAChR2, G-protein coupled receptor kinase 2 (GRK2) and the (gamma-p32) labeled ATP were incubated with paraoxon (PO), chlorpyrifos oxon (CPO) or chlorpyrifos (CPF) of varying concentrations.	Chlorpyrifos	153-165	cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)	Mus musculus	35-41
16824341-3	2006	In vitro experiments, the purified mAChR2, G-protein coupled receptor kinase 2 (GRK2) and the (gamma-p32) labeled ATP were incubated with paraoxon (PO), chlorpyrifos oxon (CPO) or chlorpyrifos (CPF) of varying concentrations.	Chlorpyrifos	153-165	G protein-coupled receptor kinase 2	Homo sapiens	80-84
16838488-6	2006	On the other hand, the known reactivators surpass new substances in the case of chlorpyrifos-inhibited AChE at both concentrations.	Chlorpyrifos	80-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-107
16182429-2	2006	This study assessed if there is an interaction between mixtures of the anticholinesterase insecticides chlorpyrifos (CHP) and carbaryl (CAR) using hypothermia and cholinesterase (ChE) inhibition as toxicological endpoints.	Chlorpyrifos	103-115	butyrylcholinesterase	Rattus norvegicus	75-89
16237519-4	2006	Samples taken 4 weeks after chlorpyrifos exposure reduced nerve growth factor (NGF)-induced neurite outgrowth by 40%.	Chlorpyrifos	28-40	nerve growth factor	Rattus norvegicus	58-77
16237519-4	2006	Samples taken 4 weeks after chlorpyrifos exposure reduced nerve growth factor (NGF)-induced neurite outgrowth by 40%.	Chlorpyrifos	28-40	nerve growth factor	Rattus norvegicus	79-82
16360256-1	2006	Chlorpyrifos is an inhibitor of cholinesterase (ChE) and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans from previous evaluations.	Chlorpyrifos	0-12	butyrylcholinesterase	Homo sapiens	32-46
16360256-1	2006	Chlorpyrifos is an inhibitor of cholinesterase (ChE) and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans from previous evaluations.	Chlorpyrifos	0-12	butyrylcholinesterase	Homo sapiens	48-51
16360256-1	2006	Chlorpyrifos is an inhibitor of cholinesterase (ChE) and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans from previous evaluations.	Chlorpyrifos	0-12	butyrylcholinesterase	Homo sapiens	71-74
16288867-2	2006	Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro.	Chlorpyrifos	58-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32
16510359-10	2006	Results demonstrated that chlorpyrifos inhibited AChE activity in blood, cerebral cortex, and hippocampus, but stress did not affect AChE activity.	Chlorpyrifos	26-38	acetylcholinesterase	Rattus norvegicus	49-53
16169541-4	2005	Chlorpyrifos treatment resulted in a significant increase in hepatic lipid peroxidation and activities of superoxide dismutase (SOD), glutathione peroxidase (G-Px) and glutathione reductase (GR).	Chlorpyrifos	0-12	glutathione-disulfide reductase	Rattus norvegicus	168-189
20021020-2	2006	The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE.	Chlorpyrifos	94-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154
20021020-5	2006	The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively.	Chlorpyrifos	80-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-28
20021020-6	2006	Chlorpyrifos was found to be a more potent inhibitor of AChE followed by the rest of the pesticides used in this study.	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
15893801-0	2005	Exposure to the organophosphorus pesticide chlorpyrifos inhibits acetylcholinesterase activity and affects muscular integrity in Xenopus laevis larvae.	Chlorpyrifos	43-55	acetylcholinesterase (Cartwright blood group) L homeolog	Xenopus laevis	65-85
15893801-1	2005	The effect of organophosphate pesticide chlorpyrifos (CPF) on acetylcholinesterase (AChE) activity and on skeletal muscle development in Xenopus laevis larvae was studied.	Chlorpyrifos	40-52	acetylcholinesterase (Cartwright blood group) L homeolog	Xenopus laevis	62-82
16260018-9	2006	Similar sequence-dependent differences in brain cholinesterase inhibition were also noted with lower binary exposures to chlorpyrifos (2 mg/kg) and parathion (0.35 mg/kg).	Chlorpyrifos	121-133	butyrylcholinesterase	Rattus norvegicus	48-62
16169541-4	2005	Chlorpyrifos treatment resulted in a significant increase in hepatic lipid peroxidation and activities of superoxide dismutase (SOD), glutathione peroxidase (G-Px) and glutathione reductase (GR).	Chlorpyrifos	0-12	glutathione-disulfide reductase	Rattus norvegicus	191-193
16169541-5	2005	On the contrary, chlorpyrifos intoxication caused a significant inhibition in the levels of reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST) activities.	Chlorpyrifos	17-29	catalase	Rattus norvegicus	119-127
16169541-5	2005	On the contrary, chlorpyrifos intoxication caused a significant inhibition in the levels of reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST) activities.	Chlorpyrifos	17-29	catalase	Rattus norvegicus	129-132
16169541-5	2005	On the contrary, chlorpyrifos intoxication caused a significant inhibition in the levels of reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST) activities.	Chlorpyrifos	17-29	hematopoietic prostaglandin D synthase	Rattus norvegicus	138-163
16169541-5	2005	On the contrary, chlorpyrifos intoxication caused a significant inhibition in the levels of reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST) activities.	Chlorpyrifos	17-29	hematopoietic prostaglandin D synthase	Rattus norvegicus	165-168
16363165-4	2005	However, DEM enhanced toxicity of chlorpyrifos to MAmCq 2.5-fold, indicating that glutathione S-transferase (GST)-mediated detoxication may play a minor role in the resistance of MAmCq.	Chlorpyrifos	34-46	glutathione S-transferase	Culex quinquefasciatus	82-107
16203236-7	2005	Our results thus indicate that apparently subtoxic neonatal chlorpyrifos exposure, devoid of effects on viability or growth but within the parameters of human fetal or neonatal exposures, produce a metabolic pattern for plasma lipids and insulin that resembles the major adult risk factors for atherosclerosis and type 2 diabetes mellitus.	Chlorpyrifos	60-72	insulin	Homo sapiens	238-245
16243090-9	2005	Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase.	Chlorpyrifos	113-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	136-156
16335048-2	2005	Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro.	Chlorpyrifos	58-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32
16363165-5	2005	An inhibition study of acetylcholinesterase (AChE) by chlorpyrifos showed that bimolecular rate constants (Ki) of chlorpyrifos for the inhibition of AChE in adults and larvae of the susceptible S-Lab strain were 2.2- and 1.9-fold higher, respectively, than in the HAmCq strain and 3.4- and 3.8-fold higher than in the MAmCq strain.	Chlorpyrifos	54-66	acetylcholinesterase	Culex quinquefasciatus	23-43
16363165-5	2005	An inhibition study of acetylcholinesterase (AChE) by chlorpyrifos showed that bimolecular rate constants (Ki) of chlorpyrifos for the inhibition of AChE in adults and larvae of the susceptible S-Lab strain were 2.2- and 1.9-fold higher, respectively, than in the HAmCq strain and 3.4- and 3.8-fold higher than in the MAmCq strain.	Chlorpyrifos	54-66	acetylcholinesterase	Culex quinquefasciatus	45-49
16363165-5	2005	An inhibition study of acetylcholinesterase (AChE) by chlorpyrifos showed that bimolecular rate constants (Ki) of chlorpyrifos for the inhibition of AChE in adults and larvae of the susceptible S-Lab strain were 2.2- and 1.9-fold higher, respectively, than in the HAmCq strain and 3.4- and 3.8-fold higher than in the MAmCq strain.	Chlorpyrifos	54-66	acetylcholinesterase	Culex quinquefasciatus	149-153
16363165-5	2005	An inhibition study of acetylcholinesterase (AChE) by chlorpyrifos showed that bimolecular rate constants (Ki) of chlorpyrifos for the inhibition of AChE in adults and larvae of the susceptible S-Lab strain were 2.2- and 1.9-fold higher, respectively, than in the HAmCq strain and 3.4- and 3.8-fold higher than in the MAmCq strain.	Chlorpyrifos	114-126	acetylcholinesterase	Culex quinquefasciatus	23-43
16363165-5	2005	An inhibition study of acetylcholinesterase (AChE) by chlorpyrifos showed that bimolecular rate constants (Ki) of chlorpyrifos for the inhibition of AChE in adults and larvae of the susceptible S-Lab strain were 2.2- and 1.9-fold higher, respectively, than in the HAmCq strain and 3.4- and 3.8-fold higher than in the MAmCq strain.	Chlorpyrifos	114-126	acetylcholinesterase	Culex quinquefasciatus	45-49
16363165-5	2005	An inhibition study of acetylcholinesterase (AChE) by chlorpyrifos showed that bimolecular rate constants (Ki) of chlorpyrifos for the inhibition of AChE in adults and larvae of the susceptible S-Lab strain were 2.2- and 1.9-fold higher, respectively, than in the HAmCq strain and 3.4- and 3.8-fold higher than in the MAmCq strain.	Chlorpyrifos	114-126	acetylcholinesterase	Culex quinquefasciatus	149-153
23923552-1	2005	Chlorpyrifos [O,O"-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothionate, CPF] undergoes oxidative desulfuration or dearylation by hepatic microsomal cytochrome P450 (CYP)-mediated monooxygenase reaction to CPF oxon or desethyl CPF, which are further metabolized to 3,5,6-trichloropyridinol (TCP).	Chlorpyrifos	0-12	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	152-167
23923552-1	2005	Chlorpyrifos [O,O"-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothionate, CPF] undergoes oxidative desulfuration or dearylation by hepatic microsomal cytochrome P450 (CYP)-mediated monooxygenase reaction to CPF oxon or desethyl CPF, which are further metabolized to 3,5,6-trichloropyridinol (TCP).	Chlorpyrifos	0-12	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	169-172
23923552-1	2005	Chlorpyrifos [O,O"-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothionate, CPF] undergoes oxidative desulfuration or dearylation by hepatic microsomal cytochrome P450 (CYP)-mediated monooxygenase reaction to CPF oxon or desethyl CPF, which are further metabolized to 3,5,6-trichloropyridinol (TCP).	Chlorpyrifos	14-74	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	152-167
23923552-1	2005	Chlorpyrifos [O,O"-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothionate, CPF] undergoes oxidative desulfuration or dearylation by hepatic microsomal cytochrome P450 (CYP)-mediated monooxygenase reaction to CPF oxon or desethyl CPF, which are further metabolized to 3,5,6-trichloropyridinol (TCP).	Chlorpyrifos	14-74	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	169-172
23923552-1	2005	Chlorpyrifos [O,O"-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothionate, CPF] undergoes oxidative desulfuration or dearylation by hepatic microsomal cytochrome P450 (CYP)-mediated monooxygenase reaction to CPF oxon or desethyl CPF, which are further metabolized to 3,5,6-trichloropyridinol (TCP).	Chlorpyrifos	76-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	152-167
23923552-1	2005	Chlorpyrifos [O,O"-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothionate, CPF] undergoes oxidative desulfuration or dearylation by hepatic microsomal cytochrome P450 (CYP)-mediated monooxygenase reaction to CPF oxon or desethyl CPF, which are further metabolized to 3,5,6-trichloropyridinol (TCP).	Chlorpyrifos	76-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	169-172
15910416-12	2005	Plasma cholinesterase activity measured 4 hr after exposure to 25 mg/kg chlorpyrifos was inhibited to approximately 40% of control levels in both strains.	Chlorpyrifos	72-84	butyrylcholinesterase	Rattus norvegicus	7-21
16007003-11	2005	The effect of PON1 removal on the dose-response curve for CPS exposure was remarkably consistent with a PBPK/PD model of CPS exposure.	Chlorpyrifos	58-61	paraoxonase 1	Mus musculus	14-18
16007003-11	2005	The effect of PON1 removal on the dose-response curve for CPS exposure was remarkably consistent with a PBPK/PD model of CPS exposure.	Chlorpyrifos	121-124	paraoxonase 1	Mus musculus	14-18
16002382-2	2005	Organophosphorus insecticides (OPs) target the developing nervous system, and until recently, the most common residential insecticides were chlorpyrifos and diazinon, two OPs metabolized in the body through the cytochrome P450/paraoxonase 1 (PON1) pathway.	Chlorpyrifos	140-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	211-240
16002382-2	2005	Organophosphorus insecticides (OPs) target the developing nervous system, and until recently, the most common residential insecticides were chlorpyrifos and diazinon, two OPs metabolized in the body through the cytochrome P450/paraoxonase 1 (PON1) pathway.	Chlorpyrifos	140-152	paraoxonase 1	Homo sapiens	242-246
15896443-4	2005	We analyze the available information from epidemiology studies and animal studies in order to identify the relative sensitivity of decreased birth weight and inhibition of ChE from exposure to chlorpyrifos.	Chlorpyrifos	193-205	butyrylcholinesterase	Homo sapiens	172-175
15896443-13	2005	Moreover, the critical effect for chlorpyrifos still appears to be cholinesterase inhibition.	Chlorpyrifos	34-46	butyrylcholinesterase	Homo sapiens	67-81
15896443-1	2005	Chlorpyrifos is an irreversible inhibitor of cholinesterase (ChE), and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans.	Chlorpyrifos	0-12	butyrylcholinesterase	Homo sapiens	45-59
15896443-1	2005	Chlorpyrifos is an irreversible inhibitor of cholinesterase (ChE), and inhibition of ChE is believed to be the most sensitive effect in all animal species evaluated and in humans.	Chlorpyrifos	0-12	butyrylcholinesterase	Homo sapiens	61-64
15207377-10	2004	It was concluded that inhibition of acetylcholinesterase activity in plasma and brain by chlorpyrifos was not enhanced by co-administration of the other four pesticides.	Chlorpyrifos	89-101	acetylcholinesterase	Rattus norvegicus	36-56
23923582-0	2005	Chlorpyrifos-induced alterations in rat brain acetylcholinesterase, lipid peroxidation and ATPases.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	46-66
23923582-1	2005	The effect of chlorpyrifos (O, O"-diethyl-3, 5, 6-trichloro-2-pyridyl phosphorothionate, CPF) exposure on acetylcholinesterase (AChE) activity, lipid peroxidation and different ATPases activities was studied in rats.	Chlorpyrifos	14-26	acetylcholinesterase	Rattus norvegicus	128-132
15527875-14	2005	CPF and its metabolites, especially CPF-oxon, contribute to the inhibition of CaE and ChE activity, as well as the alteration of BBB integrity and structure.	Chlorpyrifos	0-3	butyrylcholinesterase	Rattus norvegicus	86-89
15587241-5	2004	The activities of microsomal CYP 1A1, 2B1, 2E1 and 3AV 2 determined whether CPF, a suicide substrate of cytochrome P450 enzymes, was metabolized by the liver CYP enzymes.	Chlorpyrifos	76-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	29-36
15294802-0	2004	Altering the substrate specificity of organophosphorus hydrolase for enhanced hydrolysis of chlorpyrifos.	Chlorpyrifos	92-104	acylaminoacyl-peptide hydrolase	Homo sapiens	38-64
15294802-2	2004	However, chlorpyrifos is hydrolyzed almost 1,000-fold slower than the preferred substrate, paraoxon, by organophosphorus hydrolase (OPH), an enzyme that can degrade a broad range of organophosphate pesticides.	Chlorpyrifos	9-21	acylaminoacyl-peptide hydrolase	Homo sapiens	104-130
15294802-2	2004	However, chlorpyrifos is hydrolyzed almost 1,000-fold slower than the preferred substrate, paraoxon, by organophosphorus hydrolase (OPH), an enzyme that can degrade a broad range of organophosphate pesticides.	Chlorpyrifos	9-21	acylaminoacyl-peptide hydrolase	Homo sapiens	132-135
15802843-0	2005	Spectrophotometric determination of plasma and red blood cell cholinesterase activity of 53 fruit farm workers pre- and post-exposed chlorpyrifos for one fruit crop.	Chlorpyrifos	133-145	butyrylcholinesterase	Homo sapiens	62-76
15802843-1	2005	We sought to investigate the early biological effects of chlorpyrifos among 53 Thai fruit farm workers by measuring the plasma cholinesterase (PChE) and red blood cell cholinesterase (AChE) activities, a biomarker of organophosphate (OPs) pesticide during one fruit crop.	Chlorpyrifos	57-69	butyrylcholinesterase	Homo sapiens	127-141
15659565-0	2005	Neuroanatomical targets of the organophosphate chlorpyrifos by c-fos immunolabeling.	Chlorpyrifos	47-59	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-68
15560889-13	2004	Chlorpyrifos, an irreversible non-competitive inhibitor of CYP3A4, inhibits the formation of 3-hydroxycarbofuran in HLM (IC50: 39 microM).	Chlorpyrifos	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65
15560889-13	2004	Chlorpyrifos, an irreversible non-competitive inhibitor of CYP3A4, inhibits the formation of 3-hydroxycarbofuran in HLM (IC50: 39 microM).	Chlorpyrifos	0-12	oxysterol binding protein 2	Homo sapiens	116-119
15764407-0	2004	Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP).	Chlorpyrifos	21-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	113-116
15764407-1	2004	The cytochrome P450 (CYP)-mediated biotransformation of the organophosphorothioate insecticides chlorpyrifos and diazinon was investigated.	Chlorpyrifos	96-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-19
15764407-1	2004	The cytochrome P450 (CYP)-mediated biotransformation of the organophosphorothioate insecticides chlorpyrifos and diazinon was investigated.	Chlorpyrifos	96-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-24
15764407-6	2004	Recombinant human CYP2B6 possessed the highest desulphuration activity for chlorpyrifos, whereas CYP2C19 had the highest dearylation activity.	Chlorpyrifos	75-87	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	18-24
15764407-9	2004	However, the role of individual CYP enzymes in these two biotransformation pathways varied according to the structure of the organophosphorothioate, which was reflected in different activation/detoxification ratios for chlorpyrifos and diazinon.	Chlorpyrifos	219-231	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-35
15764407-10	2004	Variability in activity of individual CYP enzymes may influence interindividual sensitivity to the toxic effects of chlorpyrifos and diazinon.	Chlorpyrifos	116-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-41
15045467-0	2004	Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty.	Chlorpyrifos	34-46	glial fibrillary acidic protein	Rattus norvegicus	119-150
15045467-1	2004	We previously showed that maternal exposure to nicotine, alone or in combination with chlorpyrifos, caused an increase in glial fibrillary acidic protein (GFAP) immunostaining in the CA1 subfield of hippocampus and cerebellum in postnatal day (PND) 30 offspring.	Chlorpyrifos	86-98	glial fibrillary acidic protein	Rattus norvegicus	122-153
15045467-1	2004	We previously showed that maternal exposure to nicotine, alone or in combination with chlorpyrifos, caused an increase in glial fibrillary acidic protein (GFAP) immunostaining in the CA1 subfield of hippocampus and cerebellum in postnatal day (PND) 30 offspring.	Chlorpyrifos	86-98	glial fibrillary acidic protein	Rattus norvegicus	155-159
15045467-1	2004	We previously showed that maternal exposure to nicotine, alone or in combination with chlorpyrifos, caused an increase in glial fibrillary acidic protein (GFAP) immunostaining in the CA1 subfield of hippocampus and cerebellum in postnatal day (PND) 30 offspring.	Chlorpyrifos	86-98	carbonic anhydrase 1	Rattus norvegicus	183-186
15045467-6	2004	Plasma butyrylcholinesterase (BChE) activity in the female offspring from chlorpyrifos treated mothers showed a significant increase (approximately 183% of control).	Chlorpyrifos	74-86	butyrylcholinesterase	Rattus norvegicus	30-34
15045467-7	2004	Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem.	Chlorpyrifos	48-60	acetylcholinesterase	Rattus norvegicus	116-136
15045467-7	2004	Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem.	Chlorpyrifos	48-60	acetylcholinesterase	Rattus norvegicus	138-142
15045467-7	2004	Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem.	Chlorpyrifos	48-60	acetylcholinesterase	Rattus norvegicus	368-372
15045467-7	2004	Male offspring from mothers treated with either chlorpyrifos or nicotine alone showed a significant increase in the acetylcholinesterase (AChE) activity in the brainstem while female offspring from mothers treated with either nicotine or a combination of nicotine and chlorpyrifos showed a significant increase (approximately 134 and 126% of control, respectively) in AChE activity in the brainstem.	Chlorpyrifos	268-280	acetylcholinesterase	Rattus norvegicus	138-142
15045467-11	2004	These results suggest that maternal exposure to real-life levels of nicotine and/or chlorpyrifos causes differential regulation of brainstem AChE activity.	Chlorpyrifos	84-96	acetylcholinesterase	Rattus norvegicus	141-145
15130596-1	2004	The effect of chlorpyrifos (CPF) and its metabolite, chlorpyrifos-oxon (CPO), on multidrug resistance-1 (MDR1) gene expression and efflux transporter function in Caco-2 cells was determined.	Chlorpyrifos	14-26	ATP binding cassette subfamily B member 1	Homo sapiens	81-103
15130596-1	2004	The effect of chlorpyrifos (CPF) and its metabolite, chlorpyrifos-oxon (CPO), on multidrug resistance-1 (MDR1) gene expression and efflux transporter function in Caco-2 cells was determined.	Chlorpyrifos	14-26	ATP binding cassette subfamily B member 1	Homo sapiens	105-109
15141101-1	2004	The primary mechanism of action for organophosphorus (OP) insecticides, like chlorpyrifos and parathion, is to inhibit acetylcholinesterase (AChE) by their oxygenated metabolites (oxons), due to the phosphorylation of the serine hydroxyl group located in the active site of the molecule.	Chlorpyrifos	77-89	acetylcholinesterase	Rattus norvegicus	119-139
15130596-1	2004	The effect of chlorpyrifos (CPF) and its metabolite, chlorpyrifos-oxon (CPO), on multidrug resistance-1 (MDR1) gene expression and efflux transporter function in Caco-2 cells was determined.	Chlorpyrifos	28-31	ATP binding cassette subfamily B member 1	Homo sapiens	81-103
15141101-1	2004	The primary mechanism of action for organophosphorus (OP) insecticides, like chlorpyrifos and parathion, is to inhibit acetylcholinesterase (AChE) by their oxygenated metabolites (oxons), due to the phosphorylation of the serine hydroxyl group located in the active site of the molecule.	Chlorpyrifos	77-89	acetylcholinesterase	Rattus norvegicus	141-145
15130596-1	2004	The effect of chlorpyrifos (CPF) and its metabolite, chlorpyrifos-oxon (CPO), on multidrug resistance-1 (MDR1) gene expression and efflux transporter function in Caco-2 cells was determined.	Chlorpyrifos	28-31	ATP binding cassette subfamily B member 1	Homo sapiens	105-109
15018574-9	2004	The application of the method to infant food in combination with a disposable AChE biosensor enabled detection of chlorpyrifos and parathion at concentrations down to 20 microg/kg within an overall assay time of 95 min.	Chlorpyrifos	114-126	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
14704222-4	2004	Mechanisms by which chlorpyrifos may cause airway hyperreactivity include inhibition of acetylcholinesterase (AChE) or dysfunction of M3 muscarinic receptors on airway smooth muscle or of autoinhibitory M2 muscarinic receptors on parasympathetic nerves in the lung.	Chlorpyrifos	20-32	acetylcholinesterase	Cavia porcellus	88-108
14704222-4	2004	Mechanisms by which chlorpyrifos may cause airway hyperreactivity include inhibition of acetylcholinesterase (AChE) or dysfunction of M3 muscarinic receptors on airway smooth muscle or of autoinhibitory M2 muscarinic receptors on parasympathetic nerves in the lung.	Chlorpyrifos	20-32	acetylcholinesterase	Cavia porcellus	110-114
14704222-5	2004	AChE activity in the lung was significantly inhibited 24 h after treatment with 390 mg/kg of chlorpyrifos, but not 7 days after injection of 70 mg/kg of chlorpyrifos.	Chlorpyrifos	93-105	acetylcholinesterase	Cavia porcellus	0-4
14691213-0	2004	Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases.	Chlorpyrifos	0-12	mitogen activated protein kinase 14	Rattus norvegicus	94-97
14998758-7	2004	However, when the level of maternal PON1 activity was taken into account, maternal levels of chlorpyrifos above the limit of detection coupled with low maternal PON1 activity were associated with a significant but small reduction in head circumference.	Chlorpyrifos	93-105	paraoxonase 1	Homo sapiens	36-40
14998758-9	2004	Because small head size has been found to be predictive of subsequent cognitive ability, these data suggest that chlorpyrifos may have a detrimental effect on fetal neurodevelopment among mothers who exhibit low PON1 activity.	Chlorpyrifos	113-125	paraoxonase 1	Homo sapiens	212-216
14718179-12	2004	However, GFAP was elevated above control levels in the cerebral cortex of rats by all treatments (corticosterone, chlorpyrifos, TOTP).	Chlorpyrifos	114-126	glial fibrillary acidic protein	Rattus norvegicus	9-13
14691213-0	2004	Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases.	Chlorpyrifos	0-12	Eph receptor B1	Rattus norvegicus	102-105
14691213-11	2004	Transient expression of a dominant negative c-Jun mutant inhibited chlorpyrifos-induced apoptosis, suggesting a role for JNK and JNK-mediated transcription in this cell death.	Chlorpyrifos	67-79	mitogen-activated protein kinase 8	Rattus norvegicus	129-132
14691213-13	2004	Furthermore, activation of the ERK1/2 and JNK MAP kinases contributes to, while activation of the p38 MAP kinase counteracts chlorpyrifos-induced apoptosis in cortical neurons.	Chlorpyrifos	125-137	mitogen activated protein kinase 14	Rattus norvegicus	98-101
14691213-0	2004	Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases.	Chlorpyrifos	0-12	mitogen-activated protein kinase 8	Rattus norvegicus	106-109
14691213-1	2004	Chlorpyrifos, an acetylcholinesterase (AChE) inhibitor, is a widely used organophosphate pesticide.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	17-37
14691213-1	2004	Chlorpyrifos, an acetylcholinesterase (AChE) inhibitor, is a widely used organophosphate pesticide.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	39-43
14691213-4	2004	It is generally agreed that chlorpyrifos-oxon is approximately three orders of magnitude more potent than chlorpyrifos in inhibition of brain acetylcholinesterase activity.	Chlorpyrifos	28-40	acetylcholinesterase	Rattus norvegicus	142-162
14691213-7	2004	Furthermore, chlorpyrifos activates the ERK1/2 and p38 MAP kinases.	Chlorpyrifos	13-25	mitogen activated protein kinase 3	Rattus norvegicus	40-46
14998686-9	2004	Indices of cholinergic synaptic activity [hemicholinium-3 and m(2)-muscarinic acetylcholine receptor binding] showed impairment after exposure to either terbutaline or CPF but the effects were more severe when the treatments were combined.	Chlorpyrifos	168-171	cholinergic receptor, muscarinic 2	Rattus norvegicus	62-100
14691213-7	2004	Furthermore, chlorpyrifos activates the ERK1/2 and p38 MAP kinases.	Chlorpyrifos	13-25	mitogen activated protein kinase 14	Rattus norvegicus	51-54
14691213-8	2004	Surprisingly, blocking ERK1/2 activation by the MEK inhibitor SL327 caused a small but statistically significant inhibition of apoptosis, while blocking p38 with SB202190 significantly accelerated apoptosis induced by chlorpyrifos.	Chlorpyrifos	218-230	mitogen activated protein kinase 14	Rattus norvegicus	153-156
14691213-10	2004	Although chlorpyrifos did not stimulate total JNK activity, it caused a sustained activation of a sub-pool of JNK in the nucleus and stimulated phosphorylation of c-Jun, a downstream target of JNK.	Chlorpyrifos	9-21	mitogen-activated protein kinase 8	Rattus norvegicus	110-113
14691213-10	2004	Although chlorpyrifos did not stimulate total JNK activity, it caused a sustained activation of a sub-pool of JNK in the nucleus and stimulated phosphorylation of c-Jun, a downstream target of JNK.	Chlorpyrifos	9-21	mitogen-activated protein kinase 8	Rattus norvegicus	110-113
14691213-11	2004	Transient expression of a dominant negative c-Jun mutant inhibited chlorpyrifos-induced apoptosis, suggesting a role for JNK and JNK-mediated transcription in this cell death.	Chlorpyrifos	67-79	mitogen-activated protein kinase 8	Rattus norvegicus	121-124
15620088-3	2004	Oral administration of sumithion, dursban, chlordane, methoxychlore, and heptachlor epoxide as repeated doses decreased: (i) the hepatic content of cytochrome P450 by 36, 37, 47, 37, and 67%, respectively, (ii) AHH activity by 28, 29, 70, 31, and 79%, respectively, (iii) NDMA-dI activity by 43, 44, 32, 27, and 31, respectively.	Chlorpyrifos	34-41	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	211-214
14985514-4	2004	RESULTS: Chlorpyrifos and referent groups differed significantly in measures of 3,5,6 trichloro-2-pyridinol excretion and plasma butyrylcholinesterase (BuChE) activity, indicating substantially higher exposures among chlorpyrifos subjects.	Chlorpyrifos	9-21	butyrylcholinesterase	Homo sapiens	129-150
14985514-4	2004	RESULTS: Chlorpyrifos and referent groups differed significantly in measures of 3,5,6 trichloro-2-pyridinol excretion and plasma butyrylcholinesterase (BuChE) activity, indicating substantially higher exposures among chlorpyrifos subjects.	Chlorpyrifos	9-21	butyrylcholinesterase	Homo sapiens	152-157
14985514-10	2004	CONCLUSIONS: Chronic chlorpyrifos exposure during the manufacturing process sufficient to produce biological effects on BuChE activity was not associated with clinically evident or subclinical peripheral neuropathy at baseline or with measurable deterioration among chlorpyrifos subjects compared to referents after one year of additional exposure.	Chlorpyrifos	21-33	butyrylcholinesterase	Homo sapiens	120-125
14754568-0	2004	Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.	Chlorpyrifos	26-38	solute carrier family 6 member 4	Homo sapiens	182-203
12642463-8	2003	Preincubation of CYP3A4 with chlorpyrifos, but not chlorpyrifos-oxon, resulted in 98% inhibition of TST metabolism.	Chlorpyrifos	29-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	17-23
14979094-1	2003	The role of the polymorphic cytochrome P450 (CYP) 2D6 isoform in catalysing the oxidative biotransformation of the organophosphate pesticide chlorpyriphos and the carbamate aldicarb into structures that inhibit cholinesterase and induce genotoxicity has been investigated in microsomal fraction, using quinine as a specific chemical inhibitor of CYP 2D6.	Chlorpyrifos	141-154	butyrylcholinesterase	Rattus norvegicus	211-225
14979094-3	2003	Compared to microsomes incubated without quinine, where cholinesterase activity was inhibited to a mean 53% (chlorpyriphos) and 57% (aldicarb) of control, the introduction of P450 2D6 inhibitor quinine into microsomal incubation mixture reduced cholinesterase activity to 72% of control for chlorpyriphos and to 27% for aldicarb, suggesting that P450 2D6 is involved in the activation of chlorpyriphos but does not influence aldicarb toxicity on acetylcholinesterase.	Chlorpyrifos	109-122	butyrylcholinesterase	Rattus norvegicus	56-70
14979094-3	2003	Compared to microsomes incubated without quinine, where cholinesterase activity was inhibited to a mean 53% (chlorpyriphos) and 57% (aldicarb) of control, the introduction of P450 2D6 inhibitor quinine into microsomal incubation mixture reduced cholinesterase activity to 72% of control for chlorpyriphos and to 27% for aldicarb, suggesting that P450 2D6 is involved in the activation of chlorpyriphos but does not influence aldicarb toxicity on acetylcholinesterase.	Chlorpyrifos	291-304	butyrylcholinesterase	Rattus norvegicus	56-70
14979094-3	2003	Compared to microsomes incubated without quinine, where cholinesterase activity was inhibited to a mean 53% (chlorpyriphos) and 57% (aldicarb) of control, the introduction of P450 2D6 inhibitor quinine into microsomal incubation mixture reduced cholinesterase activity to 72% of control for chlorpyriphos and to 27% for aldicarb, suggesting that P450 2D6 is involved in the activation of chlorpyriphos but does not influence aldicarb toxicity on acetylcholinesterase.	Chlorpyrifos	291-304	butyrylcholinesterase	Rattus norvegicus	56-70
14761482-6	2003	Chlorpyrifos markedly reduced NAF by 66% 96 h after treatment and inhibited the AChE activity by 91% in vivo.	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	80-84
14600285-4	2004	Peak inhibition of brain cholinesterase (ChE) for CPS and CPO was determined after acute exposure to dosages of each compound (a low and a high for each), which produced similar degrees of initial ChE inhibition.	Chlorpyrifos	50-53	butyrylcholinesterase	Rattus norvegicus	25-39
14600285-4	2004	Peak inhibition of brain cholinesterase (ChE) for CPS and CPO was determined after acute exposure to dosages of each compound (a low and a high for each), which produced similar degrees of initial ChE inhibition.	Chlorpyrifos	50-53	butyrylcholinesterase	Rattus norvegicus	41-44
14600285-6	2004	This exposure paradigm resulted in persistent ChE inhibition by CPS but only transient inhibition by CPO, suggesting that, even though the initial ChE inhibition is similar between compounds, the effects of repeated exposure differ significantly.	Chlorpyrifos	64-67	butyrylcholinesterase	Rattus norvegicus	46-49
14600285-7	2004	Forebrain mAChR density, as measured by the binding of 3H-QNB, and NGF levels were significantly reduced on PND 4 and 7 after CPS but not on PND 12.	Chlorpyrifos	126-129	nerve growth factor	Rattus norvegicus	67-70
14600285-10	2004	The data suggest that the persistent ChE inhibition and decreased mAChR binding may play a role in the decreased NGF levels following CPS exposure.	Chlorpyrifos	134-137	butyrylcholinesterase	Rattus norvegicus	37-40
14600285-10	2004	The data suggest that the persistent ChE inhibition and decreased mAChR binding may play a role in the decreased NGF levels following CPS exposure.	Chlorpyrifos	134-137	nerve growth factor	Rattus norvegicus	113-116
14636698-5	2003	The pesticides iprodione, chlorpyrifos and prochloraz showed dose-dependent AhR agonistic effects in both cell lines at concentrations above 10, 1 and 1 microM, respectively.	Chlorpyrifos	26-38	aryl hydrocarbon receptor	Rattus norvegicus	76-79
14644659-1	2003	The developmental neurotoxicity of chlorpyrifos (CPF) involves mechanisms over and above cholinesterase inhibition.	Chlorpyrifos	35-47	butyrylcholinesterase	Rattus norvegicus	89-103
22900370-1	2003	The present study showed that exposure of chlorpyrifos, O,O"-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate (CPF), a widely used pesticide in rats caused significant inhibition of acetylcholinesterase (AChE) activity in different tissues viz., liver, kidney and spleen.	Chlorpyrifos	42-54	acetylcholinesterase	Rattus norvegicus	187-207
22900370-1	2003	The present study showed that exposure of chlorpyrifos, O,O"-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate (CPF), a widely used pesticide in rats caused significant inhibition of acetylcholinesterase (AChE) activity in different tissues viz., liver, kidney and spleen.	Chlorpyrifos	42-54	acetylcholinesterase	Rattus norvegicus	209-213
22900370-1	2003	The present study showed that exposure of chlorpyrifos, O,O"-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate (CPF), a widely used pesticide in rats caused significant inhibition of acetylcholinesterase (AChE) activity in different tissues viz., liver, kidney and spleen.	Chlorpyrifos	56-114	acetylcholinesterase	Rattus norvegicus	187-207
22900370-1	2003	The present study showed that exposure of chlorpyrifos, O,O"-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate (CPF), a widely used pesticide in rats caused significant inhibition of acetylcholinesterase (AChE) activity in different tissues viz., liver, kidney and spleen.	Chlorpyrifos	56-114	acetylcholinesterase	Rattus norvegicus	209-213
22900370-1	2003	The present study showed that exposure of chlorpyrifos, O,O"-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate (CPF), a widely used pesticide in rats caused significant inhibition of acetylcholinesterase (AChE) activity in different tissues viz., liver, kidney and spleen.	Chlorpyrifos	116-119	acetylcholinesterase	Rattus norvegicus	187-207
22900370-1	2003	The present study showed that exposure of chlorpyrifos, O,O"-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate (CPF), a widely used pesticide in rats caused significant inhibition of acetylcholinesterase (AChE) activity in different tissues viz., liver, kidney and spleen.	Chlorpyrifos	116-119	acetylcholinesterase	Rattus norvegicus	209-213
14555401-0	2003	Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine.	Chlorpyrifos	196-208	glial fibrillary acidic protein	Rattus norvegicus	24-55
14555401-5	2003	On PND 7, there was a significant increase in brain acetylcholinesterase (AChE) activity in pups from nicotine- and chlorpyrifos-treated dams, whereas plasma butyrylcholinesterase (BChE) activity was significantly elevated in pups of mothers treated with either chlorpyrifos alone or pesticide combined with nicotine.	Chlorpyrifos	116-128	acetylcholinesterase	Rattus norvegicus	52-72
14555401-5	2003	On PND 7, there was a significant increase in brain acetylcholinesterase (AChE) activity in pups from nicotine- and chlorpyrifos-treated dams, whereas plasma butyrylcholinesterase (BChE) activity was significantly elevated in pups of mothers treated with either chlorpyrifos alone or pesticide combined with nicotine.	Chlorpyrifos	116-128	acetylcholinesterase	Rattus norvegicus	74-78
14555401-7	2003	In female pups on PND 30 there was a significant rise in AChE activity in brainstem of chlorpyrifos alone and in cerebellum of the combination nicotine and chlorpyrifos group.	Chlorpyrifos	87-99	acetylcholinesterase	Rattus norvegicus	57-61
14555401-7	2003	In female pups on PND 30 there was a significant rise in AChE activity in brainstem of chlorpyrifos alone and in cerebellum of the combination nicotine and chlorpyrifos group.	Chlorpyrifos	156-168	acetylcholinesterase	Rattus norvegicus	57-61
14555401-9	2003	A rise in glial fibrillary acidic protein (GFAP) immunostaining was observed in the CA1 subfield of hippocampus and cerebellum on PND 30 in female and male offspring of mothers treated with either nicotine or nicotine in combination with chlorpyrifos, but to a lesser extent in males.	Chlorpyrifos	238-250	glial fibrillary acidic protein	Rattus norvegicus	10-41
14555401-9	2003	A rise in glial fibrillary acidic protein (GFAP) immunostaining was observed in the CA1 subfield of hippocampus and cerebellum on PND 30 in female and male offspring of mothers treated with either nicotine or nicotine in combination with chlorpyrifos, but to a lesser extent in males.	Chlorpyrifos	238-250	glial fibrillary acidic protein	Rattus norvegicus	43-47
14555401-9	2003	A rise in glial fibrillary acidic protein (GFAP) immunostaining was observed in the CA1 subfield of hippocampus and cerebellum on PND 30 in female and male offspring of mothers treated with either nicotine or nicotine in combination with chlorpyrifos, but to a lesser extent in males.	Chlorpyrifos	238-250	carbonic anhydrase 1	Rattus norvegicus	84-87
14555401-10	2003	Data suggest that maternal exposure to nicotine and chlorpyrifos, alone or in combination, produces differential alterations in brain regional AChE activity and expression of GFAP in cerebellum and hippocampus in offspring on PND 30.	Chlorpyrifos	52-64	acetylcholinesterase	Rattus norvegicus	143-147
14555401-10	2003	Data suggest that maternal exposure to nicotine and chlorpyrifos, alone or in combination, produces differential alterations in brain regional AChE activity and expression of GFAP in cerebellum and hippocampus in offspring on PND 30.	Chlorpyrifos	52-64	glial fibrillary acidic protein	Rattus norvegicus	175-179
12767693-1	2003	The primary mechanism of action for organophosphorus (OP) insecticides such as chlorpyrifos (CPF) involves the inhibition of acetylcholinesterase (AChE) by their active oxon metabolites resulting in a wide range of neurotoxic effects.	Chlorpyrifos	79-91	acetylcholinesterase	Rattus norvegicus	125-145
12767693-1	2003	The primary mechanism of action for organophosphorus (OP) insecticides such as chlorpyrifos (CPF) involves the inhibition of acetylcholinesterase (AChE) by their active oxon metabolites resulting in a wide range of neurotoxic effects.	Chlorpyrifos	79-91	acetylcholinesterase	Rattus norvegicus	147-151
12767693-1	2003	The primary mechanism of action for organophosphorus (OP) insecticides such as chlorpyrifos (CPF) involves the inhibition of acetylcholinesterase (AChE) by their active oxon metabolites resulting in a wide range of neurotoxic effects.	Chlorpyrifos	93-96	acetylcholinesterase	Rattus norvegicus	125-145
12767693-1	2003	The primary mechanism of action for organophosphorus (OP) insecticides such as chlorpyrifos (CPF) involves the inhibition of acetylcholinesterase (AChE) by their active oxon metabolites resulting in a wide range of neurotoxic effects.	Chlorpyrifos	93-96	acetylcholinesterase	Rattus norvegicus	147-151
12655035-1	2003	Chlorpyrifos (CPF) and diazinon (DZN) are thionophosphorus organophosphate (OP) insecticides; their toxicity is mediated through CYP metabolism to CPF-oxon and DZN-oxon, respectively.	Chlorpyrifos	0-12	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	129-132
12655035-1	2003	Chlorpyrifos (CPF) and diazinon (DZN) are thionophosphorus organophosphate (OP) insecticides; their toxicity is mediated through CYP metabolism to CPF-oxon and DZN-oxon, respectively.	Chlorpyrifos	14-17	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	129-132
12655035-3	2003	In addition, A-esterase (PON1) metabolism of CPF- and DZN-oxon also forms TCP and IMHP.	Chlorpyrifos	45-49	paraoxonase 1	Rattus norvegicus	25-29
12655035-7	2003	In enterocyte microsomes, the CYP metabolic efficiency for metabolism to the oxon metabolites was approximately 28-fold greater for CPF than DZN.	Chlorpyrifos	132-135	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	30-33
12655035-11	2003	PON1-mediated metabolism of CPF- and DZN-oxon was also demonstrated in liver and enterocyte microsomes.	Chlorpyrifos	28-31	paraoxonase 1	Rattus norvegicus	0-4
12519632-1	2003	Paraoxonase (PON1) is an A-esterase capable of hydrolysing the active metabolites (oxons) of a number of organophosphorus (OP) insecticides such as parathion, diazinon and chlorpyrifos.	Chlorpyrifos	172-184	paraoxonase 1	Mus musculus	13-17
12521672-9	2003	These results indicate that gestational exposure to chlorpyrifos results in relatively persistent inhibition of brain cholinesterase and a delayed depression of choline acetyltransferase at a time when brain cholinesterase activity had returned to control levels in the high-dosage group.	Chlorpyrifos	52-64	butyrylcholinesterase	Rattus norvegicus	118-132
12521672-9	2003	These results indicate that gestational exposure to chlorpyrifos results in relatively persistent inhibition of brain cholinesterase and a delayed depression of choline acetyltransferase at a time when brain cholinesterase activity had returned to control levels in the high-dosage group.	Chlorpyrifos	52-64	choline O-acetyltransferase	Rattus norvegicus	161-186
12521672-9	2003	These results indicate that gestational exposure to chlorpyrifos results in relatively persistent inhibition of brain cholinesterase and a delayed depression of choline acetyltransferase at a time when brain cholinesterase activity had returned to control levels in the high-dosage group.	Chlorpyrifos	52-64	butyrylcholinesterase	Rattus norvegicus	208-222
12022498-7	2002	The degradation of chlorpyrifos in soil from the starch formulations could be described in a non-linear logistic model and the half-life was predicted to be 88 days.	Chlorpyrifos	19-31	Brahma associated protein 170kD	Drosophila melanogaster	127-136
12472152-0	2002	Dissipation of chlorpyrifos from tap, river and brackish waters in glass aquaria.	Chlorpyrifos	15-27	nuclear RNA export factor 1	Homo sapiens	33-36
12088877-3	2002	Two organochlorine pesticides (methoxychlor and chlorpyrifos) were tested for their effects on GnRH gene expression and biosynthesis in the immortalized hypothalamic GT1-7 cells, which synthesize and secrete GnRH.	Chlorpyrifos	48-60	gonadotropin releasing hormone 1	Mus musculus	95-99
12088877-3	2002	Two organochlorine pesticides (methoxychlor and chlorpyrifos) were tested for their effects on GnRH gene expression and biosynthesis in the immortalized hypothalamic GT1-7 cells, which synthesize and secrete GnRH.	Chlorpyrifos	48-60	retinoic acid induced 1	Mus musculus	166-169
12088877-4	2002	GT1-7 cells were treated with methoxychlor or chlorpyrifos for 24 h in dose-response experiments, and GnRH gene expression and peptide levels were quantified.	Chlorpyrifos	46-58	retinoic acid induced 1	Mus musculus	0-3
12088877-6	2002	Both methoxychlor and chlorpyrifos had significant effects on GnRH gene transcription and GnRH mRNA levels.	Chlorpyrifos	22-34	gonadotropin releasing hormone 1	Mus musculus	62-66
12088877-6	2002	Both methoxychlor and chlorpyrifos had significant effects on GnRH gene transcription and GnRH mRNA levels.	Chlorpyrifos	22-34	gonadotropin releasing hormone 1	Mus musculus	90-94
12088877-8	2002	Chlorpyrifos and methoxychlor slightly stimulated peptide levels, and this effect was blocked by ICI, suggesting that the ER may mediate effects of pesticides on GnRH release.	Chlorpyrifos	0-12	estrogen receptor 1 (alpha)	Mus musculus	122-124
12088877-8	2002	Chlorpyrifos and methoxychlor slightly stimulated peptide levels, and this effect was blocked by ICI, suggesting that the ER may mediate effects of pesticides on GnRH release.	Chlorpyrifos	0-12	gonadotropin releasing hormone 1	Mus musculus	162-166
12088877-9	2002	These results indicate that chlorpyrifos and methoxychlor alter GnRH biosynthesis in this hypothalamic cell line in vitro, suggesting that they may have endocrine disrupting effects on GnRH neurons in vivo.	Chlorpyrifos	28-40	gonadotropin releasing hormone 1	Mus musculus	64-68
12088877-9	2002	These results indicate that chlorpyrifos and methoxychlor alter GnRH biosynthesis in this hypothalamic cell line in vitro, suggesting that they may have endocrine disrupting effects on GnRH neurons in vivo.	Chlorpyrifos	28-40	gonadotropin releasing hormone 1	Mus musculus	185-189
12175464-0	2002	EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos.	Chlorpyrifos	100-112	acetylcholinesterase	Rattus norvegicus	69-89
12403052-0	2002	Possible role of vasopressin in the thermoregulatory response to chlorpyrifos in the rat.	Chlorpyrifos	65-77	arginine vasopressin	Rattus norvegicus	17-28
12403052-4	2002	Because arginine vasopressin is a potent hypertensive agent and is capable of lowering core temperature, we suspected that arginine vasopressin may be involved in the thermoregulatory response to chlorpyrifos.	Chlorpyrifos	196-208	arginine vasopressin	Rattus norvegicus	17-28
12403052-4	2002	Because arginine vasopressin is a potent hypertensive agent and is capable of lowering core temperature, we suspected that arginine vasopressin may be involved in the thermoregulatory response to chlorpyrifos.	Chlorpyrifos	196-208	arginine vasopressin	Rattus norvegicus	132-143
12403052-13	2002	That the V1 antagonist blocked the hypothermic effect of chlorpyrifos suggests that the thermoregulatory response to chlorpyrifos is mediated by central and/or systemic vasopressin release.	Chlorpyrifos	57-69	arginine vasopressin	Rattus norvegicus	169-180
12403052-14	2002	The lack of a significant increase in plasma vasopressin after chlorpyrifos suggests that localized release of vasopressin may be involved in the thermoregulatory response to chlorpyrifos.	Chlorpyrifos	175-187	arginine vasopressin	Rattus norvegicus	111-122
12385721-0	2002	In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos.	Chlorpyrifos	79-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	41-56
12385721-11	2002	Chlorpyrifos inhibited the generation of carbaryl methylol, catalyzed predominately by CYP2B6, more than other pathways, correlating with an earlier observation that chlorpyrifos is metabolized to its oxon primarily by CYP2B6.	Chlorpyrifos	0-12	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-93
12385721-11	2002	Chlorpyrifos inhibited the generation of carbaryl methylol, catalyzed predominately by CYP2B6, more than other pathways, correlating with an earlier observation that chlorpyrifos is metabolized to its oxon primarily by CYP2B6.	Chlorpyrifos	0-12	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	219-225
12385721-11	2002	Chlorpyrifos inhibited the generation of carbaryl methylol, catalyzed predominately by CYP2B6, more than other pathways, correlating with an earlier observation that chlorpyrifos is metabolized to its oxon primarily by CYP2B6.	Chlorpyrifos	166-178	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-93
12385721-11	2002	Chlorpyrifos inhibited the generation of carbaryl methylol, catalyzed predominately by CYP2B6, more than other pathways, correlating with an earlier observation that chlorpyrifos is metabolized to its oxon primarily by CYP2B6.	Chlorpyrifos	166-178	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	219-225
12242675-4	2002	Cholinesterase activity in male spiders was inhibited to 14% and 61% of control activity by Basudin and Lorsban, respectively.	Chlorpyrifos	104-111	butyrylcholinesterase	Homo sapiens	0-14
11861971-2	2002	This model integrates target tissue dosimetry and dynamic response (i.e., esterase inhibition) describing uptake, metabolism, and disposition of CPF, CPF-oxon, and TCP and the associated cholinesterase (ChE) inhibition kinetics in blood and tissues following acute and chronic oral and dermal exposure.	Chlorpyrifos	145-148	butyrylcholinesterase	Rattus norvegicus	187-201
11854147-9	2002	Preincubation of human CYP2B6 with chlorpyrifos completely inhibited the metabolism of DEET.	Chlorpyrifos	35-47	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	23-29
11861971-7	2002	The time course of CPF and TCP in both species was linear over the dose range evaluated, and the model reasonably simulated the dose-dependent inhibition of plasma ChE, RBC acetylcholinesterase (AChE), and brain (rat only) AChE.	Chlorpyrifos	19-22	butyrylcholinesterase	Rattus norvegicus	164-167
11875622-0	2002	Inhibition and recovery of maternal and fetal cholinesterase enzymes following a single oral dose of chlorpyrifos in rats.	Chlorpyrifos	101-113	butyrylcholinesterase	Rattus norvegicus	46-60
11861971-7	2002	The time course of CPF and TCP in both species was linear over the dose range evaluated, and the model reasonably simulated the dose-dependent inhibition of plasma ChE, RBC acetylcholinesterase (AChE), and brain (rat only) AChE.	Chlorpyrifos	19-22	acetylcholinesterase	Rattus norvegicus	195-199
11861971-7	2002	The time course of CPF and TCP in both species was linear over the dose range evaluated, and the model reasonably simulated the dose-dependent inhibition of plasma ChE, RBC acetylcholinesterase (AChE), and brain (rat only) AChE.	Chlorpyrifos	19-22	acetylcholinesterase	Rattus norvegicus	223-227
11861971-9	2002	This CPF PBPK/PD model quantitatively estimates target tissue dosimetry and AChE inhibition and is a strong framework for further organophosphate (OP) model development and for refining a biologically based risk assessment for exposure to CPF under a variety of scenarios.	Chlorpyrifos	5-8	acetylcholinesterase	Rattus norvegicus	76-80
11882345-0	2002	Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein.	Chlorpyrifos	0-12	glial fibrillary acidic protein	Homo sapiens	49-80
11598781-0	2001	Chlorpyrifos-induced hsp70 expression and effect on reproductive performance in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9.	Chlorpyrifos	0-12	Heat-shock-protein-70Ab	Drosophila melanogaster	21-26
11744161-8	2001	Additional studies were carried out to determine whether chlorpyrifos is a substrate for the multidrug resistance protein, P-glycoprotein (P-gp).	Chlorpyrifos	57-69	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	123-137
11744161-8	2001	Additional studies were carried out to determine whether chlorpyrifos is a substrate for the multidrug resistance protein, P-glycoprotein (P-gp).	Chlorpyrifos	57-69	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	139-143
11714865-0	2001	Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.	Chlorpyrifos	108-120	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
11714865-12	2001	Testosterone and the insecticide chlorpyrifos were used to assess the catalytic activities of the most common CYP3A4 allele (CYP3A4*1) and its allelic variants.	Chlorpyrifos	33-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	110-116
11714865-13	2001	CYP3A4 F189S exhibited lower turnover numbers for testosterone and chlorpyrifos, while CYP3A4 L293P had higher turnover numbers for both substrates.	Chlorpyrifos	67-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
11598781-0	2001	Chlorpyrifos-induced hsp70 expression and effect on reproductive performance in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9.	Chlorpyrifos	0-12	Heat-shock-protein-70Ab	Drosophila melanogaster	116-121
11598781-1	2001	Expression of hsp70 in the third-instar larval tissues of transgenic Drosophila melanogaster (hsp70-lacZ) following dietary exposure to organophosphate insecticide chlorpyrifos for various time intervals was investigated.	Chlorpyrifos	164-176	Heat-shock-protein-70Ab	Drosophila melanogaster	14-19
11598781-1	2001	Expression of hsp70 in the third-instar larval tissues of transgenic Drosophila melanogaster (hsp70-lacZ) following dietary exposure to organophosphate insecticide chlorpyrifos for various time intervals was investigated.	Chlorpyrifos	164-176	Heat-shock-protein-70Ab	Drosophila melanogaster	94-99
11598781-11	2001	The present study suggests that certain larval tissues of Drosophila, a nontarget organism, are vulnerable to chlorpyrifos as evidenced by hsp70 expression.	Chlorpyrifos	110-122	Heat-shock-protein-70Ab	Drosophila melanogaster	139-144
11881970-1	2001	The organophosphate insecticide chlorpyrifos and the carbamate insecticide carbaryl were investigated in adult male rats in terms of their effects on the activity of brain monoamine oxidase-A (MAO-A) activity and on the platelet uptake of 5-hydroxytryptamine (5-HT).	Chlorpyrifos	32-44	monoamine oxidase A	Rattus norvegicus	172-191
11712994-0	2001	Transferable residues from dog fur and plasma cholinesterase inhibition in dogs treated with a flea control dip containing chlorpyrifos.	Chlorpyrifos	123-135	butyrylcholinesterase	Canis lupus familiaris	46-60
11557094-0	2001	Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos.	Chlorpyrifos	95-107	solute carrier family 6 member 4	Rattus norvegicus	15-36
11881970-1	2001	The organophosphate insecticide chlorpyrifos and the carbamate insecticide carbaryl were investigated in adult male rats in terms of their effects on the activity of brain monoamine oxidase-A (MAO-A) activity and on the platelet uptake of 5-hydroxytryptamine (5-HT).	Chlorpyrifos	32-44	monoamine oxidase A	Rattus norvegicus	193-198
11881970-5	2001	Acute chlorpyrifos administration produced a 85.01% inhibition of AChE and a 43.4% inhibition of BuChE but had no effect on MAO-A activity and 5-HT uptake.	Chlorpyrifos	6-18	acetylcholinesterase	Rattus norvegicus	66-70
11881970-5	2001	Acute chlorpyrifos administration produced a 85.01% inhibition of AChE and a 43.4% inhibition of BuChE but had no effect on MAO-A activity and 5-HT uptake.	Chlorpyrifos	6-18	butyrylcholinesterase	Rattus norvegicus	97-102
11881970-6	2001	In contrast, subacute chlorpyrifos exposure caused a 94.96% inhibition of AChE and a 85.8% inhibition of BuChE and, also, elicited a significant (35.02%) reduction in the platelet uptake of 5-HT.	Chlorpyrifos	22-34	acetylcholinesterase	Rattus norvegicus	74-78
11881970-6	2001	In contrast, subacute chlorpyrifos exposure caused a 94.96% inhibition of AChE and a 85.8% inhibition of BuChE and, also, elicited a significant (35.02%) reduction in the platelet uptake of 5-HT.	Chlorpyrifos	22-34	butyrylcholinesterase	Rattus norvegicus	105-110
11601461-7	2001	In terms of accuracy, the method meets the requirements for all pesticides in both matrixes, except for lindane in bottled water and lindane and chlorpyrifos in tap water.	Chlorpyrifos	145-157	nuclear RNA export factor 1	Homo sapiens	161-164
11502728-0	2001	Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes.	Chlorpyrifos	14-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	36-51
11690566-4	2001	The protoxicants chlorpyrifos and parathion produced acetylcholinesterase inhibition after multiple exposures although no inhibition was seen following a single exposure to these agents.	Chlorpyrifos	17-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73
11548114-1	2001	The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain.	Chlorpyrifos	178-190	butyrylcholinesterase	Rattus norvegicus	201-215
11548114-1	2001	The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain.	Chlorpyrifos	178-190	butyrylcholinesterase	Rattus norvegicus	217-220
11548114-1	2001	The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain.	Chlorpyrifos	178-190	acetylcholinesterase	Rattus norvegicus	292-312
11548114-1	2001	The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain.	Chlorpyrifos	178-190	acetylcholinesterase	Rattus norvegicus	314-318
11275418-1	2001	The acute toxicity of chlorpyrifos oxon (CPO), the metabolically-activated form of the major organophosphorus insecticide chlorpyrifos, is attributable to diethylphosphorylation of acetylcholinesterase at its esteratic site.	Chlorpyrifos	22-34	acetylcholinesterase	Rattus norvegicus	181-201
11548114-3	2001	Acute exposure to CPF (166 mg/kg and 250 mg/kg, s.c.) produced significant dose-dependent inhibition (54% and 71%, respectively) of whole-brain AChE 48 hours after treatment.	Chlorpyrifos	18-21	acetylcholinesterase	Rattus norvegicus	144-148
11405414-0	2001	Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination, in pregnant rats.	Chlorpyrifos	71-83	butyrylcholinesterase	Rattus norvegicus	14-28
11405414-2	2001	Chlorpyrifos inhibited maternal and fetal brain acetylcholinesterase (AChE) activity within 24 h of dosing, (48% and 67% of control activity, respectively).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	48-68
11405414-2	2001	Chlorpyrifos inhibited maternal and fetal brain acetylcholinesterase (AChE) activity within 24 h of dosing, (48% and 67% of control activity, respectively).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	70-74
11405414-4	2001	A combination of chlorpyrifos and methyl parathion produced peak inhibition of maternal and fetal brain AChE activity at 24 h postdosing (35% and 73% of control activity, respectively).	Chlorpyrifos	17-29	acetylcholinesterase	Rattus norvegicus	104-108
11405414-9	2001	Significant inhibition of placental AChE occurred within 24 h after application of methyl parathion or chlorpyrifos alone or in combination.	Chlorpyrifos	103-115	acetylcholinesterase	Rattus norvegicus	36-40
11405414-10	2001	The results suggest that methyl parathion and chlorpyrifos, alone or in combination, were rapidly distributed in maternal and fetal tissues, resulting in rapid inhibition of cholinesterase enzyme activities.	Chlorpyrifos	46-58	butyrylcholinesterase	Rattus norvegicus	174-188
11405414-11	2001	The lower inhibitory effect of the combination could be due to competition between chlorpyrifos and methyl parathion for cytochrome P-450 enzymes, resulting in inhibition of the formation of the potent cholinesterase inhibitor oxon forms.	Chlorpyrifos	83-95	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	121-137
11405414-11	2001	The lower inhibitory effect of the combination could be due to competition between chlorpyrifos and methyl parathion for cytochrome P-450 enzymes, resulting in inhibition of the formation of the potent cholinesterase inhibitor oxon forms.	Chlorpyrifos	83-95	butyrylcholinesterase	Rattus norvegicus	202-216
11223004-0	2001	Changes in EEG power spectra and behavioral states in rats exposed to the acetylcholinesterase inhibitor chlorpyrifos and muscarinic agonist oxotremorine.	Chlorpyrifos	105-117	acetylcholinesterase	Rattus norvegicus	74-94
11298499-2	2001	The effects of in vitro exposure of brain (target) and serum (biomarker) ChE to chlorpyrifos-oxon (C horizontal lineO) and azinphos-methyl-oxon (AZM horizontal lineO), the active metabolites of the insecticides chlorpyrifos and azinphos-methyl, respectively, were investigated to determine if simultaneous or sequential exposure to these two OP compounds results in purely additive effects.	Chlorpyrifos	80-92	butyrylcholinesterase	Homo sapiens	73-76
11394642-9	2001	In in vivo experiments, three of the toxicants (Aroclor 1221, methoxychlor, and chlorpyrifos) caused significant alterations in GnRH mRNA levels in female rats.	Chlorpyrifos	80-92	gonadotropin releasing hormone 1	Rattus norvegicus	128-132
11307850-1	2001	Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	98-118
11307850-1	2001	Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	120-124
11307850-1	2001	Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	98-118
11307850-1	2001	Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	120-124
10996483-4	2000	Compared to control incubations (no inhibitor) where cholinesterase activity was inhibited to between 1 and 4% of control levels, incorporation of the CYP2D6 inhibitor quinidine into the microsomal incubation resulted in cholinesterase activity of 50% for parathion, 38% for diazinon and 30% for chlorpyrifos.	Chlorpyrifos	296-308	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	151-157
11158719-13	2001	These data suggest that early postnatal chlorpyrifos exposures will depress locomotor activity in juvenile rats, with the effects most pronounced after brain ChE activity has substantially recovered.	Chlorpyrifos	40-52	butyrylcholinesterase	Rattus norvegicus	158-161
11748873-1	2001	The aim of the study was to evaluate the neurotoxic effect of a dermally-applied mixture of chlorpyrifos and cypermethrin in rats based on cognitive function, activity of the blood cholinesterase and brain acetylcholinesterase, as well as histologic brain examination.	Chlorpyrifos	92-104	butyrylcholinesterase	Rattus norvegicus	181-195
11748873-11	2001	The results of the study showed that chlorpyrifos and cypermethrin applied in a mixture caused an inhibition of cholinesterase and acetylcholinesterase activity and elicited the pycnosis of brain neurocytes.	Chlorpyrifos	37-49	butyrylcholinesterase	Rattus norvegicus	112-126
11748873-11	2001	The results of the study showed that chlorpyrifos and cypermethrin applied in a mixture caused an inhibition of cholinesterase and acetylcholinesterase activity and elicited the pycnosis of brain neurocytes.	Chlorpyrifos	37-49	acetylcholinesterase	Rattus norvegicus	131-151
10996483-5	2000	Addition of the CYP3A4 inhibitor ketoconazole to microsomal incubations resulted in 66% cholinesterase activity with diazinon, 20% with parathion and 5% with chlorpyrifos.	Chlorpyrifos	158-170	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	16-22
10996483-6	2000	The unexpected finding that CYP2D6, as well as CYP3A4, catalysed oxidative biotransformation was confirmed for chlorpyrifos and parathion using microsomes prepared from a human lymphoblastoid cell line expressing CYP2D6.	Chlorpyrifos	111-123	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	28-34
10996483-6	2000	The unexpected finding that CYP2D6, as well as CYP3A4, catalysed oxidative biotransformation was confirmed for chlorpyrifos and parathion using microsomes prepared from a human lymphoblastoid cell line expressing CYP2D6.	Chlorpyrifos	111-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-53
10996483-7	2000	While parathion has been investigated only as a model compound, chlorpyrifos and diazinon are both very important, widely used pesticides and CYP2D6 appears to be an important enzyme in their bioactivation pathway.	Chlorpyrifos	64-76	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	142-148
10996483-8	2000	CYP2D6 is polymorphic and hence may influence individual susceptibility to exposure to chlorpyrifos and diazinon as well as other structurally similar pesticides.	Chlorpyrifos	87-99	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
10898114-2	2000	PON1 also hydrolyses the bioactive oxon forms of organophosphorus pesticides such as parathion, diazinon and chlorpyrifos.	Chlorpyrifos	109-121	paraoxonase 1	Homo sapiens	0-4
10873710-0	2000	Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures.	Chlorpyrifos	32-44	acetylcholinesterase	Rattus norvegicus	87-107
10931542-11	2000	The validated procedures provide excellent tools for the specific assessment of occupational exposure to the organophosphorus pesticide chlorpyrifos, throughout the analysis of both human serum and urine, and it is more selective and sensitive than the current assay based on the measurement of the decrease in the cholinesterase activity.	Chlorpyrifos	136-148	butyrylcholinesterase	Homo sapiens	315-329
10876030-4	2000	Administration of 1 mg/kg s.c. of chlorpyrifos on postnatal (PN) days 1-4 elicited deficits in reflex righting on PN3-4 and in geotaxic responses on PN5-8, an effect that was specific to females.	Chlorpyrifos	34-46	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	114-119
10876030-6	2000	In the periweaning period, open-field locomotor activity and rearing were markedly reduced in male rats that had been exposed to chlorpyrifos on PN1-4, whereas no effect was detected in females.	Chlorpyrifos	129-141	serpin family E member 2	Rattus norvegicus	145-150
10876030-7	2000	The gender-selective behavioral effects were associated with greater sensitivity of males to inhibition of cholinesterase in the first few hours after chlorpyrifos treatment.	Chlorpyrifos	151-163	butyrylcholinesterase	Rattus norvegicus	107-121
10837889-3	2000	Newborn rats were given 1 mg/kg of chlorpyrifos s.c. on PN1-4.	Chlorpyrifos	35-47	serpin family E member 2	Rattus norvegicus	56-61
10753086-2	2000	Houses and lawns in the United States receive a total of approximately 20 million annual chlorpyrifos treatments, and 82% of U.S. adults have detectable levels of a chlorpyrifos metabolite (3,5, 6-trichloro-2-pyridinol; TCP) in the urine.	Chlorpyrifos	165-177	serine peptidase inhibitor Kazal type 1	Homo sapiens	220-223
10794389-13	2000	Injection of purified rabbit PON1 protects mice from cholinesterase inhibition by chlorpyrifos (CPS) and CPO.	Chlorpyrifos	82-94	serum paraoxonase/arylesterase 1	Oryctolagus cuniculus	29-33
10794393-0	2000	In vitro and in vivo effects of chlorpyrifos on glutathione peroxidase and catalase in developing rat brain.	Chlorpyrifos	32-44	catalase	Rattus norvegicus	75-83
10794393-1	2000	Preliminary findings of a study on the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos (CPF) indicates that in vitro exposure to 1-100 microM CPF or 1-100 nM CPF-oxon had no effect on the activity of glutathione peroxidase (GSHpx) in brain homogenates from postnatal day (PN) 21 rats, or on the activity of purified GSHpx.	Chlorpyrifos	102-114	glutathione peroxidase 1	Rattus norvegicus	252-257
10794393-1	2000	Preliminary findings of a study on the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos (CPF) indicates that in vitro exposure to 1-100 microM CPF or 1-100 nM CPF-oxon had no effect on the activity of glutathione peroxidase (GSHpx) in brain homogenates from postnatal day (PN) 21 rats, or on the activity of purified GSHpx.	Chlorpyrifos	102-114	glutathione peroxidase 1	Rattus norvegicus	344-349
11051590-3	2000	It was observed that chlorpyrifos (13.5 mg/kg body weight) treatment resulted in significant inhibition (p < 0.001) of serum and hepatic acetylcholinesterase (AChE) activities after 8 wk.	Chlorpyrifos	21-33	acetylcholinesterase	Rattus norvegicus	140-160
11051590-3	2000	It was observed that chlorpyrifos (13.5 mg/kg body weight) treatment resulted in significant inhibition (p < 0.001) of serum and hepatic acetylcholinesterase (AChE) activities after 8 wk.	Chlorpyrifos	21-33	acetylcholinesterase	Rattus norvegicus	162-166
11051590-6	2000	alkaline phosphatase, aspartate aminotransferase [AST], and alanine aminotransferase [ALT]) was observed following treatment with chlorpyrifos.	Chlorpyrifos	130-142	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	22-48
11051590-6	2000	alkaline phosphatase, aspartate aminotransferase [AST], and alanine aminotransferase [ALT]) was observed following treatment with chlorpyrifos.	Chlorpyrifos	130-142	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	50-53
10700556-2	2000	Although chlorpyrifos exerts some effects through cholinesterase inhibition, recent studies suggest additional, direct actions on developing cells.	Chlorpyrifos	9-21	butyrylcholinesterase	Rattus norvegicus	50-64
10700556-5	2000	In concentrations previously shown to affect cell development, chlorpyrifos reduced AP-1, but not Sp1 DNA-binding activity.	Chlorpyrifos	63-75	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-88
10700556-7	2000	Chlorpyrifos evoked stage-specific interference with the expression of the transcription factors: Sp1 was reduced in replicating and differentiating cells, whereas AP-1 was affected only during differentiation.	Chlorpyrifos	0-12	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	164-168
10700556-9	2000	Again, chlorpyrifos evoked stage-specific changes in transcription factor expression and binding activity, with greater effects on Sp1 during active neurogenesis, and effects on AP-1 during differentiation.	Chlorpyrifos	7-19	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	178-182
10681099-2	2000	Doses of chlorpyrifos, parathion, acephate, and trichlorfon that inhibited AChE >70% were administered to the embryos.	Chlorpyrifos	9-21	acetylcholinesterase (Cartwright blood group)	Gallus gallus	75-79
10514030-0	1999	Tumor necrosis factor is involved in chlorpyrifos--induced changes in core temperature in the female rat.	Chlorpyrifos	37-49	tumor necrosis factor-like	Rattus norvegicus	0-21
10544056-0	1999	Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action?	Chlorpyrifos	55-67	acetylcholinesterase	Rattus norvegicus	92-112
10568702-0	1999	Gestational exposure to chlorpyrifos: dose response profiles for cholinesterase and carboxylesterase activity.	Chlorpyrifos	24-36	butyrylcholinesterase	Rattus norvegicus	65-79
10568702-1	1999	This study investigates the in vivo dose response profiles of the target enzyme cholinesterase (ChE) and the detoxifying enzymes carboxylesterase (CaE) in the fetal and maternal compartments of pregnant rats dosed with chlorpyrifos [(O,O"-diethyl O-3,5,6-trichloro-2-pyridyl) phosphorothionate], a commonly used organophosphorus insecticide.	Chlorpyrifos	219-231	butyrylcholinesterase	Rattus norvegicus	80-94
10568702-1	1999	This study investigates the in vivo dose response profiles of the target enzyme cholinesterase (ChE) and the detoxifying enzymes carboxylesterase (CaE) in the fetal and maternal compartments of pregnant rats dosed with chlorpyrifos [(O,O"-diethyl O-3,5,6-trichloro-2-pyridyl) phosphorothionate], a commonly used organophosphorus insecticide.	Chlorpyrifos	219-231	butyrylcholinesterase	Rattus norvegicus	96-99
10568702-1	1999	This study investigates the in vivo dose response profiles of the target enzyme cholinesterase (ChE) and the detoxifying enzymes carboxylesterase (CaE) in the fetal and maternal compartments of pregnant rats dosed with chlorpyrifos [(O,O"-diethyl O-3,5,6-trichloro-2-pyridyl) phosphorothionate], a commonly used organophosphorus insecticide.	Chlorpyrifos	233-293	butyrylcholinesterase	Rattus norvegicus	80-94
10568702-5	1999	In vivo exposure to 10 mg/kg chlorpyrifos from GD14-18 caused overt maternal toxicity, with dose-related decreases in ChE activity more notable in maternal brain than fetal brain.	Chlorpyrifos	29-41	butyrylcholinesterase	Rattus norvegicus	118-121
10568702-6	1999	Dose-related effects were also seen with chlorpyrifos-induced inhibition of fetal liver ChE and maternal brain CaE activities.	Chlorpyrifos	41-53	butyrylcholinesterase	Rattus norvegicus	88-91
10568702-8	1999	ChE activities in the maternal blood and liver, as well as fetal and maternal liver CaE, however, were maximally inhibited by even the lowest dosage of chlorpyrifos.	Chlorpyrifos	152-164	butyrylcholinesterase	Rattus norvegicus	0-3
10543028-0	1999	Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development.	Chlorpyrifos	120-132	butyrylcholinesterase	Rattus norvegicus	21-35
10543028-11	1999	In addition, repeated direct oral exposures of early postnatal rats to CPS will result in persistent brain ChE inhibition and will transiently reduce muscarinic receptor density.	Chlorpyrifos	71-74	butyrylcholinesterase	Rattus norvegicus	107-110
10421480-18	1999	Furthermore, protection by PON1 is also provided toward the parent compound chlorpyrifos.	Chlorpyrifos	76-88	paraoxonase 1	Mus musculus	27-31
10413184-0	1999	Are circulating cytokines interleukin-6 and tumor necrosis factor alpha involved in chlorpyrifos-induced fever?	Chlorpyrifos	84-96	interleukin 6	Rattus norvegicus	26-39
10413184-0	1999	Are circulating cytokines interleukin-6 and tumor necrosis factor alpha involved in chlorpyrifos-induced fever?	Chlorpyrifos	84-96	tumor necrosis factor	Rattus norvegicus	44-71
10429680-12	1999	After a thorough review of the experimental animal literature, it was determined that the chlorpyrifos repeated-exposure RfD based on application of a 100-fold uncertainty factor on the no observed adverse effects level (NOAEL) for brain cholinesterase inhibition or on a 10-fold uncertainty factor on the NOAEL for erythrocyte cholinesterase inhibition is 0.01 mg/kg/d.	Chlorpyrifos	90-102	butyrylcholinesterase	Homo sapiens	238-252
10429680-12	1999	After a thorough review of the experimental animal literature, it was determined that the chlorpyrifos repeated-exposure RfD based on application of a 100-fold uncertainty factor on the no observed adverse effects level (NOAEL) for brain cholinesterase inhibition or on a 10-fold uncertainty factor on the NOAEL for erythrocyte cholinesterase inhibition is 0.01 mg/kg/d.	Chlorpyrifos	90-102	butyrylcholinesterase	Homo sapiens	328-342
10349701-7	1999	Chlorpyrifos had no effect on macrophage phagocytosis (P = 0.27), but increased the relative percentage expression of CD5+ (P = 0.028) and CD8+ (P = 0.003).	Chlorpyrifos	0-12	Cd5 molecule	Rattus norvegicus	118-121
10229710-5	1999	These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban).	Chlorpyrifos	190-202	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
10229710-5	1999	These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban).	Chlorpyrifos	204-211	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
9685159-1	1998	Serum paraoxonase (PON1) is an esterase that is associated with high-density lipoproteins (HDLs) in the plasma; it is involved in the detoxification of organophosphate insecticides such as parathion and chlorpyrifos.	Chlorpyrifos	203-215	paraoxonase 1	Mus musculus	19-23
9744565-2	1998	The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity.	Chlorpyrifos	27-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85
9744565-2	1998	The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity.	Chlorpyrifos	27-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-91
10051415-0	1999	Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose.	Chlorpyrifos	125-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	21-41
10051415-4	1999	Basing an acceptable level of human exposure (e.g., RfD) on inhibition of RBC AChE provides a significant margin of safety, since it is 12- to 14-fold more sensitive as an indicator of chlorpyrifos exposure than the AChE in the most sensitive relevant neurological tissues (brain or retina).	Chlorpyrifos	185-197	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
10051415-5	1999	Inhibition of RBC AChE activity is consistently exhibited at lower dosages of chlorpyrifos than those required to result in clinical symptoms of OP toxicity, or alterations in cognitive functional responses.	Chlorpyrifos	78-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-22
10051415-7	1999	Thus, inhibition of RBC AChE activity is an appropriate surrogate measurement of chlorpyrifos exposure and provides a conservative endpoint for establishing appropriate margins of safety for both adults and infants.	Chlorpyrifos	81-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-28
9745924-13	1998	Injection of purified PON1 into mice clearly demonstrates the protective effect of having high serum levels of PON1 against toxicity by chlorpyrifos oxon or chlorpyrifos.	Chlorpyrifos	136-148	paraoxonase 1	Mus musculus	22-26
9745924-13	1998	Injection of purified PON1 into mice clearly demonstrates the protective effect of having high serum levels of PON1 against toxicity by chlorpyrifos oxon or chlorpyrifos.	Chlorpyrifos	136-148	paraoxonase 1	Mus musculus	111-115
18967015-0	1997	Robotic sample pretreatment-immunoassay determination of chlorpyrifos metabolite (TCP) in soil and fruit.	Chlorpyrifos	57-69	serine peptidase inhibitor Kazal type 1	Homo sapiens	82-85
9561967-2	1998	Previous studies in our laboratory have demonstrated, however, that dosages of the OPs chlorpyrifos (CPF) or parathion (PS), which cause similar degrees of brain AChE inhibition in adult male rats, can produce marked differences in toxicity.	Chlorpyrifos	87-99	acetylcholinesterase	Rattus norvegicus	162-166
9561967-2	1998	Previous studies in our laboratory have demonstrated, however, that dosages of the OPs chlorpyrifos (CPF) or parathion (PS), which cause similar degrees of brain AChE inhibition in adult male rats, can produce marked differences in toxicity.	Chlorpyrifos	101-104	acetylcholinesterase	Rattus norvegicus	162-166
9705902-9	1998	After introduction of NGF, chlorpyrifos maintained its ability to inhibit DNA synthesis acutely.	Chlorpyrifos	27-39	nerve growth factor	Rattus norvegicus	22-25
9705902-11	1998	We also tested the effects of long-term exposure to chlorpyrifos during the process of NGF-induced differentiation.	Chlorpyrifos	52-64	nerve growth factor	Rattus norvegicus	87-90
9443830-2	1998	In developing rat brain, chlorpyrifos doses that cause no discernible systemic toxicity and only a minor degree of cholinesterase inhibition, nevertheless evoke alterations in cell function and number that appear after several days" delay.	Chlorpyrifos	25-37	butyrylcholinesterase	Rattus norvegicus	115-129
9465262-5	1998	AChE IC50 values were determined by incubating tissue homogenates with chlorpyrifos-oxon (active metabolite of chlorpyrifos, a common organophosphate insecticide) for 30 min at 26 degrees C, and then measuring residual AChE activity.	Chlorpyrifos	71-83	acetylcholinesterase	Rattus norvegicus	0-4
18967015-1	1997	A fully automated method for leaching of TCP (3,5,6-trichloro-2-pyridinol, the major degradation product of the widely used chlorpyrifos insecticides) from soil and fruit with subsequent determination by ELISA is reported.	Chlorpyrifos	124-136	serine peptidase inhibitor Kazal type 1	Homo sapiens	41-44
9336338-1	1997	Chlorpyrifos (CPF) is a cholinesterase-inhibiting organophosphate pesticide used extensively to treat crops and domestic animals.	Chlorpyrifos	0-12	butyrylcholinesterase	Rattus norvegicus	24-38
9461846-4	1997	Moreover, immunoblotting responses of microsomal protein encoded by Cyp6A2 showed that the levels of expression were quantitatively correlated with toxicological tolerance to almost the same group of insecticides (deltamethrin, fipronil, chlorpyriphos ethyl, DDT, fenvalerate, and fenthion).	Chlorpyrifos	238-257	Cytochrome P450-6a2	Drosophila melanogaster	68-74
9336338-1	1997	Chlorpyrifos (CPF) is a cholinesterase-inhibiting organophosphate pesticide used extensively to treat crops and domestic animals.	Chlorpyrifos	14-17	butyrylcholinesterase	Rattus norvegicus	24-38
9299188-0	1997	Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison.	Chlorpyrifos	27-39	butyrylcholinesterase	Rattus norvegicus	64-78
8896566-8	1996	The insecticides parathion, chlorpyrifos and diazinon are bioactivated to potent cholinesterase inhibitors by cytochrome P-450 systems.	Chlorpyrifos	28-40	butyrylcholinesterase	Homo sapiens	81-95
8954750-7	1996	In contrast, a significant inhibition of brain acetylcholinesterase (AChE) was produced in hens administered chlorpyrifos alone (activity 67% of control), while those given chlorpyrifos in combination with other compounds exhibited a significant inhibition of brain AChE activity ranging from 43 to 76%.	Chlorpyrifos	109-121	acetylcholinesterase (Cartwright blood group)	Gallus gallus	47-67
8954750-7	1996	In contrast, a significant inhibition of brain acetylcholinesterase (AChE) was produced in hens administered chlorpyrifos alone (activity 67% of control), while those given chlorpyrifos in combination with other compounds exhibited a significant inhibition of brain AChE activity ranging from 43 to 76%.	Chlorpyrifos	109-121	acetylcholinesterase (Cartwright blood group)	Gallus gallus	69-73
8954750-7	1996	In contrast, a significant inhibition of brain acetylcholinesterase (AChE) was produced in hens administered chlorpyrifos alone (activity 67% of control), while those given chlorpyrifos in combination with other compounds exhibited a significant inhibition of brain AChE activity ranging from 43 to 76%.	Chlorpyrifos	109-121	acetylcholinesterase (Cartwright blood group)	Gallus gallus	266-270
8954750-7	1996	In contrast, a significant inhibition of brain acetylcholinesterase (AChE) was produced in hens administered chlorpyrifos alone (activity 67% of control), while those given chlorpyrifos in combination with other compounds exhibited a significant inhibition of brain AChE activity ranging from 43 to 76%.	Chlorpyrifos	173-185	acetylcholinesterase (Cartwright blood group)	Gallus gallus	266-270
8954750-8	1996	Brain neurotoxicity target esterase (NTE) was not inhibited in any of the individual treatment groups or PB/DEET, but was significantly inhibited and had activity expressed as a percentage of control in groups administered combined chlorpyrifos with PB of 73% or DEET of 74% and in the tertiary treatment group of 71%.	Chlorpyrifos	232-244	patatin like phospholipase domain containing 6	Gallus gallus	37-40
8937895-1	1996	High, subcutaneous doses of the organophosphorus insecticide chlorpyrifos (CPF) in adult male rats can be well-tolerated despite extensive and persistent acetylcholinesterase (AChE) inhibition.	Chlorpyrifos	61-73	acetylcholinesterase	Rattus norvegicus	154-174
8937895-1	1996	High, subcutaneous doses of the organophosphorus insecticide chlorpyrifos (CPF) in adult male rats can be well-tolerated despite extensive and persistent acetylcholinesterase (AChE) inhibition.	Chlorpyrifos	61-73	acetylcholinesterase	Rattus norvegicus	176-180
8937895-1	1996	High, subcutaneous doses of the organophosphorus insecticide chlorpyrifos (CPF) in adult male rats can be well-tolerated despite extensive and persistent acetylcholinesterase (AChE) inhibition.	Chlorpyrifos	75-78	acetylcholinesterase	Rattus norvegicus	154-174
9292287-3	1997	2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing.	Chlorpyrifos	70-82	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
8727219-6	1996	Changes were observed in all 6 bands of the serum ChE isoenzymes after administration of fenthion, chlorpyrifos and propaphos.	Chlorpyrifos	99-111	butyrylcholinesterase	Rattus norvegicus	50-53
8593081-2	1996	Since chlorpyrifos inhibits acetylcholinesterase, the acetylcholine-innervated ciliated epithelial cultures of frog palate were used as the model.	Chlorpyrifos	6-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-48
8600291-3	1996	In this study, we investigated whether the organophosphorus insecticide chlorpyrifos (O,O-diethyl O-3,5,6-trichloro-2-pyridinyl phosphorothioate) or its metabolites interact with P-gp.	Chlorpyrifos	72-84	ATP binding cassette subfamily B member 1	Homo sapiens	179-183
8600291-3	1996	In this study, we investigated whether the organophosphorus insecticide chlorpyrifos (O,O-diethyl O-3,5,6-trichloro-2-pyridinyl phosphorothioate) or its metabolites interact with P-gp.	Chlorpyrifos	86-144	ATP binding cassette subfamily B member 1	Homo sapiens	179-183
8600291-4	1996	Immunohistochemical analysis of tissues from male Fischer 344 rats administered chlorpyrifos (7.6 mg/kg gavage) showed increased P-gp expression in the kidney, adrenal, liver, jejunum, and stomach (tissues associated with elimination of xenobiotics), compared to control tissues.	Chlorpyrifos	80-92	phosphoglycolate phosphatase	Rattus norvegicus	129-133
8600291-8	1996	A concentration-dependent inhibition of [3H]azidopine labeling of P-gp was detected with chlorpyrifos oxon, while significant inhibition was not detected with chlorpyrifos.	Chlorpyrifos	89-101	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
7541841-2	1995	Exposure to both parent compounds produced identical initial inhibition (95%), but in the later sampling times there was significantly more inhibited AChE in the chlorpyrifos-treated fish than in the parathion-treated fish (47% and 28%, respectively, on d 16).	Chlorpyrifos	162-174	acetylcholinesterase	Ictalurus punctatus	150-154
7500172-9	1995	L-PK mRNA induction by the CP diet was significantly reduced by dietary polyunsaturated fatty acids (CPF diet), whereas the GK mRNA induction was not significantly reduced.	Chlorpyrifos	101-104	pyruvate kinase L/R	Rattus norvegicus	0-4
7541841-3	1995	There were higher levels of aged AChE following chlorpyrifos exposure than following parathion exposure, but differences were not significant.	Chlorpyrifos	48-60	acetylcholinesterase	Ictalurus punctatus	33-37
7541841-5	1995	The similar patterns of inhibition, recovery, and aging between the two oxon treatments, which have similar lipophilicities, suggest that the greater amount of AChE inhibition and aging observed in the chlorpyrifos-treated fish compared with the parathion-treated fish probably results from the higher lipophilicity of chlorpyrifos than of parathion.	Chlorpyrifos	202-214	acetylcholinesterase	Ictalurus punctatus	160-164
7513360-2	1994	The current study verifies that the insecticide O,O-diethyl O-3,5,6-trichloro-2-pyridinyl phosphorothionate (chlorpyrifos) and its oxon metabolite inhibits acetylcholinesterase (AChE).	Chlorpyrifos	109-121	acetylcholinesterase	Rattus norvegicus	156-176
7537966-0	1995	Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos.	Chlorpyrifos	104-116	acetylcholinesterase	Rattus norvegicus	21-41
7537966-1	1995	When given to rats, O,O"-diethyl-O-[3,5,6-trichloro-2-pyridyl]- phosphorothionate (chlorpyrifos), a common insecticide, causes an unusually lengthy dose-dependent fall in the activity of brain acetylcholinesterase (AChE; EC 3.1.1.7).	Chlorpyrifos	20-81	acetylcholinesterase	Rattus norvegicus	193-213
7537966-1	1995	When given to rats, O,O"-diethyl-O-[3,5,6-trichloro-2-pyridyl]- phosphorothionate (chlorpyrifos), a common insecticide, causes an unusually lengthy dose-dependent fall in the activity of brain acetylcholinesterase (AChE; EC 3.1.1.7).	Chlorpyrifos	20-81	acetylcholinesterase	Rattus norvegicus	215-219
7537966-1	1995	When given to rats, O,O"-diethyl-O-[3,5,6-trichloro-2-pyridyl]- phosphorothionate (chlorpyrifos), a common insecticide, causes an unusually lengthy dose-dependent fall in the activity of brain acetylcholinesterase (AChE; EC 3.1.1.7).	Chlorpyrifos	83-95	acetylcholinesterase	Rattus norvegicus	193-213
7537966-1	1995	When given to rats, O,O"-diethyl-O-[3,5,6-trichloro-2-pyridyl]- phosphorothionate (chlorpyrifos), a common insecticide, causes an unusually lengthy dose-dependent fall in the activity of brain acetylcholinesterase (AChE; EC 3.1.1.7).	Chlorpyrifos	83-95	acetylcholinesterase	Rattus norvegicus	215-219
7537966-7	1995	Larger increases of AChE-IR were observed after chlorpyrifos was administered for 4 weeks by the oral route.	Chlorpyrifos	48-60	acetylcholinesterase	Rattus norvegicus	20-24
7537966-9	1995	Overall, it appears that chronically reduced brain AChE activity after chlorpyrifos reflects sustained enzyme inhibition, not loss of enzyme protein or suppression of AChE message.	Chlorpyrifos	71-83	acetylcholinesterase	Rattus norvegicus	51-55
7532610-4	1995	MOSs for potential chronic dietary exposure to chlorpyrifos residues were based on a NOEL for inhibition of brain cholinesterase activity in rats and dogs, and ranged from 2198 to 8065 for all population subgroups.	Chlorpyrifos	47-59	butyrylcholinesterase	Rattus norvegicus	114-128
7531775-9	1995	In accord with the much greater inhibitory potency of chlorpyrifos oxon for AChE than for NTE, clinical reports and experimental studies indicate that OPIDN from acute exposures to chlorpyrifos requires doses well in excess of the LD50, even when followed by repeated doses of the OPIDN potentiator phenylmethanesulfonyl fluoride (PMSF).	Chlorpyrifos	54-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-80
7531776-1	1995	Chlorpyrifos (CPF), an organophosphorus (OP) insecticide, exerts toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	96-116
7531776-1	1995	Chlorpyrifos (CPF), an organophosphorus (OP) insecticide, exerts toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase	Rattus norvegicus	118-122
7531776-1	1995	Chlorpyrifos (CPF), an organophosphorus (OP) insecticide, exerts toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	96-116
7531776-1	1995	Chlorpyrifos (CPF), an organophosphorus (OP) insecticide, exerts toxicity through inhibition of acetylcholinesterase (AChE).	Chlorpyrifos	14-17	acetylcholinesterase	Rattus norvegicus	118-122
7520881-2	1994	A kinetic analysis of cytochrome P-450 mediated desulfuration (activation) and dearylation (detoxication) of the two insecticides indicated that rat hepatic microsomes have a higher capacity to activate and a lower capacity to detoxify parathion than chlorpyrifos; these capacities correspond to their acute toxicity levels.	Chlorpyrifos	251-263	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	22-38
7518512-0	1994	Repeated inhibition of cholinesterase by chlorpyrifos in rats: behavioral, neurochemical and pharmacological indices of tolerance.	Chlorpyrifos	41-53	butyrylcholinesterase	Rattus norvegicus	23-37
7518512-3	1994	In the present study, weekly injections of CPF (0, 15, 30 or 60 mg/kg s.c.) inhibited ChE activity in whole blood of rats by 60% to 90% after 5 weeks; the highest dose also induced tremor, working memory impairment and motor slowing in daily delayed matching-to-position/visual discrimination tests.	Chlorpyrifos	43-46	butyrylcholinesterase	Rattus norvegicus	86-89
7531775-3	1995	Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences.	Chlorpyrifos	8-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-139
7531775-3	1995	Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences.	Chlorpyrifos	8-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-145
7531775-3	1995	Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences.	Chlorpyrifos	8-20	patatin like phospholipase domain containing 6	Homo sapiens	279-305
7531775-3	1995	Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences.	Chlorpyrifos	8-20	patatin like phospholipase domain containing 6	Homo sapiens	307-310
7531775-3	1995	Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences.	Chlorpyrifos	352-364	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-139
7531775-3	1995	Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences.	Chlorpyrifos	352-364	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-145
7531775-5	1995	Rats given large doses of chlorpyrifos (sc in oil) have prolonged inhibition of brain AChE, possibly due to slow release of the parent compound from a depot.	Chlorpyrifos	26-38	acetylcholinesterase	Rattus norvegicus	86-90
7513360-2	1994	The current study verifies that the insecticide O,O-diethyl O-3,5,6-trichloro-2-pyridinyl phosphorothionate (chlorpyrifos) and its oxon metabolite inhibits acetylcholinesterase (AChE).	Chlorpyrifos	109-121	acetylcholinesterase	Rattus norvegicus	178-182
7522308-6	1994	PND21 exposure to chlorpyrifos produced dose-related inhibition and recovery of brain AChE over the PND24-27 age range.	Chlorpyrifos	18-30	acetylcholinesterase	Rattus norvegicus	86-90
7689099-0	1993	Behavioral and neurochemical effects of acute chlorpyrifos in rats: tolerance to prolonged inhibition of cholinesterase.	Chlorpyrifos	46-58	butyrylcholinesterase	Rattus norvegicus	105-119
7504821-3	1993	Repeated doses of CPF (40 mg/kg, SC, every 4 days, total of 4 doses) caused extensive inhibition of cortical, hippocampal, and striatal cholinesterase (ChE) activity in adult rats at 4 (90-92%) and 14 (71-78%) days after the last treatment.	Chlorpyrifos	18-21	butyrylcholinesterase	Rattus norvegicus	136-150
7504821-3	1993	Repeated doses of CPF (40 mg/kg, SC, every 4 days, total of 4 doses) caused extensive inhibition of cortical, hippocampal, and striatal cholinesterase (ChE) activity in adult rats at 4 (90-92%) and 14 (71-78%) days after the last treatment.	Chlorpyrifos	18-21	butyrylcholinesterase	Rattus norvegicus	152-155
7684990-0	1993	Inhibition of hen brain acetylcholinesterase and neurotoxic esterase by chlorpyrifos in vivo and kinetics of inhibition by chlorpyrifos oxon in vitro: application to assessment of neuropathic risk.	Chlorpyrifos	72-84	acetylcholinesterase (Cartwright blood group)	Gallus gallus	24-44
7689992-6	1993	Aliesterases were inhibited to a greater extent than acetylcholinesterase at each sampling time with parathion and chlorpyrifos and their oxons, whereas the reverse was true with methyl parathion and methyl paraoxon.	Chlorpyrifos	115-127	acetylcholinesterase	Rattus norvegicus	53-73
7689993-0	1993	Chlorpyrifos: assessment of potential for delayed neurotoxicity by repeated dosing in adult hens with monitoring of brain acetylcholinesterase, brain and lymphocyte neurotoxic esterase, and plasma butyrylcholinesterase activities.	Chlorpyrifos	0-12	butyrylcholinesterase	Gallus gallus	197-218
7689993-1	1993	Previous work has shown that acute exposures to chlorpyrifos (CPS; diethyl 3,5,6-trichloro-2-pyridyl phosphorothionate) cannot produce > 70% inhibition of brain neurotoxic esterase (NTE) and cause organophosphorus compound-induced delayed neurotoxicity (OPIDN) unless the dose is well in excess of the LD50, necessitating aggressive therapy for cholinergic toxicity.	Chlorpyrifos	48-60	patatin like phospholipase domain containing 6	Gallus gallus	164-183
7689993-1	1993	Previous work has shown that acute exposures to chlorpyrifos (CPS; diethyl 3,5,6-trichloro-2-pyridyl phosphorothionate) cannot produce > 70% inhibition of brain neurotoxic esterase (NTE) and cause organophosphorus compound-induced delayed neurotoxicity (OPIDN) unless the dose is well in excess of the LD50, necessitating aggressive therapy for cholinergic toxicity.	Chlorpyrifos	48-60	patatin like phospholipase domain containing 6	Gallus gallus	185-188
7689993-1	1993	Previous work has shown that acute exposures to chlorpyrifos (CPS; diethyl 3,5,6-trichloro-2-pyridyl phosphorothionate) cannot produce > 70% inhibition of brain neurotoxic esterase (NTE) and cause organophosphorus compound-induced delayed neurotoxicity (OPIDN) unless the dose is well in excess of the LD50, necessitating aggressive therapy for cholinergic toxicity.	Chlorpyrifos	62-65	patatin like phospholipase domain containing 6	Gallus gallus	164-183
7689993-1	1993	Previous work has shown that acute exposures to chlorpyrifos (CPS; diethyl 3,5,6-trichloro-2-pyridyl phosphorothionate) cannot produce > 70% inhibition of brain neurotoxic esterase (NTE) and cause organophosphorus compound-induced delayed neurotoxicity (OPIDN) unless the dose is well in excess of the LD50, necessitating aggressive therapy for cholinergic toxicity.	Chlorpyrifos	62-65	patatin like phospholipase domain containing 6	Gallus gallus	185-188
7689993-2	1993	The present study was carried out to determine if repeated doses of CPS at the maximum tolerated daily dose without prophylaxis against cholinergic toxicity could cause cumulative inhibition of NTE and OPIDN.	Chlorpyrifos	68-71	patatin like phospholipase domain containing 6	Gallus gallus	194-197
7689993-5	1993	During Days 4-20, brain AChE and plasma BuChE activities from CPS-treated hens were inhibited 58-70% and 49-80% of contemporaneous controls, respectively.	Chlorpyrifos	62-65	acetylcholinesterase (Cartwright blood group)	Gallus gallus	24-28
7689993-5	1993	During Days 4-20, brain AChE and plasma BuChE activities from CPS-treated hens were inhibited 58-70% and 49-80% of contemporaneous controls, respectively.	Chlorpyrifos	62-65	butyrylcholinesterase	Gallus gallus	40-45
7684990-0	1993	Inhibition of hen brain acetylcholinesterase and neurotoxic esterase by chlorpyrifos in vivo and kinetics of inhibition by chlorpyrifos oxon in vitro: application to assessment of neuropathic risk.	Chlorpyrifos	72-84	patatin like phospholipase domain containing 6	Gallus gallus	49-68
1445194-4	1992	Kinetic constants determined for four insecticides, temephos, chlorpyrifos, fenitrothion and propoxur indicate the rates of acylation and the affinities of binding of the insecticides to this carboxylesterase are important.	Chlorpyrifos	62-74	esterase 6	Culex quinquefasciatus	192-208
1378635-1	1992	A single dose of the organophosphate insecticide O,O"-diethyl-O-3,5,6- trichloro-2-pyridylphosphorothioate [chlorpyrifos (CPF), 279 mg/kg, SC] caused extensive inhibition of cortical and striatal cholinesterase (ChE) activity in adult rats at 2 (94-96%), 4 (82-83%), and 6 (58-60%) weeks after treatment.	Chlorpyrifos	49-106	butyrylcholinesterase	Rattus norvegicus	212-215
34748799-9	2022	The thyroidal function related genes dio3b was upregulated by chlorpyrifos and downregulated by higher abamectin concentrations.	Chlorpyrifos	62-74	iodothyronine deiodinase 3b	Danio rerio	37-42
1375401-2	1992	The present study examined dose-related inhibition of both brain and plasma cholinesterase activity in neonatal and adult rats exposed to sublethal doses of one of three common OP pesticides, methyl parathion, parathion and chlorpyrifos.	Chlorpyrifos	224-236	butyrylcholinesterase	Rattus norvegicus	76-90
1697627-5	1990	Notably, the reduction of ChE activities by fenthion, chlorpyrifos and dichlorvos were similar.	Chlorpyrifos	54-66	butyrylcholinesterase	Rattus norvegicus	26-29
1690462-1	1990	Paraoxon and chlorpyrifos-oxon, the active metabolites of the organophosphorus insecticides parathion and chlorpyrifos, respectively, are hydrolyzed by an "A"-esterase, paraoxonase, which is present in the sera of several mammalian species.	Chlorpyrifos	13-25	paraoxonase 1	Homo sapiens	169-180
1711837-5	1991	Chlorpyrifos was slowly absorbed after single oral doses and the threshold of inhibition (greater than 70%) of neuropathy target esterase (NTE), the putative target for delayed neuropathy, was reached within 5-6 days.	Chlorpyrifos	0-12	patatin like phospholipase domain containing 6	Homo sapiens	111-137
1711837-5	1991	Chlorpyrifos was slowly absorbed after single oral doses and the threshold of inhibition (greater than 70%) of neuropathy target esterase (NTE), the putative target for delayed neuropathy, was reached within 5-6 days.	Chlorpyrifos	0-12	patatin like phospholipase domain containing 6	Homo sapiens	139-142
1711837-6	1991	High AChE inhibition (greater than 90%), however, was measured within hours after dosing because of the higher potency of chlorpyrifos to inhibit this enzyme.	Chlorpyrifos	122-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	5-9
1711837-7	1991	In vitro studies showed that chlorpyrifos-oxon, the active metabolite of chlorpyrifos, was 10-20 times more active against AChE than against NTE, confirming the clinical observation.	Chlorpyrifos	29-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-127
1711837-7	1991	In vitro studies showed that chlorpyrifos-oxon, the active metabolite of chlorpyrifos, was 10-20 times more active against AChE than against NTE, confirming the clinical observation.	Chlorpyrifos	29-41	patatin like phospholipase domain containing 6	Homo sapiens	141-144
1378635-1	1992	A single dose of the organophosphate insecticide O,O"-diethyl-O-3,5,6- trichloro-2-pyridylphosphorothioate [chlorpyrifos (CPF), 279 mg/kg, SC] caused extensive inhibition of cortical and striatal cholinesterase (ChE) activity in adult rats at 2 (94-96%), 4 (82-83%), and 6 (58-60%) weeks after treatment.	Chlorpyrifos	49-106	butyrylcholinesterase	Rattus norvegicus	196-210
32797872-4	2020	Calibration curves were obtained for chlorpyrifos and carbaryl, with a useful concentration range from 0.24 to 20 mug L-1 for carbaryl and from 2.00 to 45 mug L-1 for chlorpyrifos.	Chlorpyrifos	37-49	L1 cell adhesion molecule	Homo sapiens	118-121
34756920-8	2022	These findings suggest chlorpyrifos may influence lipid metabolism through blocking the degradation of eCBs or eCB-like metabolites and in turn affecting PPAR receptor activation.	Chlorpyrifos	23-35	peroxisome proliferator activated receptor alpha	Homo sapiens	154-158
34338973-0	2021	Pinocembrin pretreatment counteracts the chlorpyrifos-induced HO-1 downregulation, mitochondrial dysfunction, and inflammation in the SH-SY5Y cells.	Chlorpyrifos	41-53	heme oxygenase 1	Homo sapiens	62-66
34818764-5	2022	Chlorpyrifos increased mortality, growth rate and the energy consumed, and reduced the AChE (acetylcholinesterase) activity, the energy available, and the net energy budget (estimated as cellular energy allocation).	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-91
34818764-5	2022	Chlorpyrifos increased mortality, growth rate and the energy consumed, and reduced the AChE (acetylcholinesterase) activity, the energy available, and the net energy budget (estimated as cellular energy allocation).	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	93-113
34494438-4	2021	Under the optimal conditions, the detection limits (expressed as IC10) of triazophos, parathion, and chlorpyrifos were 0.22, 0.45, and 4.49 ng mL-1, respectively.	Chlorpyrifos	101-113	L1 cell adhesion molecule	Mus musculus	143-147
34559034-0	2021	Impairment of apoptosis pathway via Apaf1 downregulation during chlorpyrifos and/or cypermethrin induced lung damage.	Chlorpyrifos	64-76	apoptotic peptidase activating factor 1	Mus musculus	36-41
34559034-7	2021	The immunohistochemistry depicted reduced expression of Apaf1 in both airway epithelium and alveolar septa following exposure to chlorpyrifos and/or cypermethrin.	Chlorpyrifos	129-141	apoptotic peptidase activating factor 1	Mus musculus	56-61
34559034-8	2021	In conclusion, results demonstrated that exposure to chlorpyrifos, cypermethrin and their combination cause lung damage by the dysregulation of Apaf1 gene expression.	Chlorpyrifos	53-65	apoptotic peptidase activating factor 1	Mus musculus	144-149
34817298-8	2021	Further, the residues of chlorpyrifos and monocrotophos among FW were found to be significantly correlating with the mean percentages of CD19+ and CD8+ markers, respectively.	Chlorpyrifos	25-37	CD19 molecule	Homo sapiens	137-141
34817298-8	2021	Further, the residues of chlorpyrifos and monocrotophos among FW were found to be significantly correlating with the mean percentages of CD19+ and CD8+ markers, respectively.	Chlorpyrifos	25-37	CD8a molecule	Homo sapiens	147-150
34289071-0	2021	Bbc3 loss enhances survival and protein clearance in neurons exposed to the organophosphate pesticide chlorpyrifos.	Chlorpyrifos	102-114	BCL2 binding component 3	Mus musculus	0-4
34453052-4	2021	Using a step-wise screening approach, we discover that the organophosphate insecticide chlorpyrifos suppresses UCP1 and mitochondrial respiration in BAT at concentrations as low as 1 pM.	Chlorpyrifos	87-99	uncoupling protein 1	Homo sapiens	111-115
34424684-0	2021	Aryl Hydrocarbon Receptor Activation Produces Heat Shock Protein 90 and 70 Overexpression, Prostaglandin E2/Wnt/beta-Catenin Signaling Disruption, and Cell Proliferation in MCF-7 and MDA-MB-231 Cells after 24 h and 14 Days of Chlorpyrifos Treatment.	Chlorpyrifos	226-238	aryl hydrocarbon receptor	Homo sapiens	0-25
34482881-5	2021	Under the optimal conditions, linearity for the determination of fenitrothion, malathion, ethion, chlorpyrifos, and diazinon was in the concentration ranges of 0.13-1100, 0.27-1000, 0.38-1000, 0.21-1200, and 0.11-1100 ng mL-1 with a determination coefficient higher than 0.9906, respectively.	Chlorpyrifos	98-110	L1 cell adhesion molecule	Mus musculus	221-225
34088207-10	2021	The absorbance at 652 nm linearly increases with increasing chlorpyrifos concentration in the range of 2-20 ng mL-1 with detection limit of 0.57 ng mL-1 (S/N = 3).	Chlorpyrifos	60-72	L1 cell adhesion molecule	Mus musculus	111-115
34088207-10	2021	The absorbance at 652 nm linearly increases with increasing chlorpyrifos concentration in the range of 2-20 ng mL-1 with detection limit of 0.57 ng mL-1 (S/N = 3).	Chlorpyrifos	60-72	L1 cell adhesion molecule	Mus musculus	148-152
34250774-10	2021	Chlorpyrifos (100 mg/kg) alone and in combination with caffeine (40 mg/kg) significantly reduced acetylcholinesterase (AChE) activity.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	97-117
34352351-0	2021	3,5,6-trichloro-2-pyridinol intensifies the effect of chlorpyrifos on the paracrine function of Sertoli cells by preventing binding of testosterone and the androgen receptor.	Chlorpyrifos	54-66	androgen receptor	Homo sapiens	156-173
34259569-0	2021	Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres.	Chlorpyrifos	94-106	chromodomain helicase DNA binding protein 8	Homo sapiens	111-115
34259569-4	2021	OBJECTIVES: In this study, we aimed to identify a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 (CHD8) and environmental exposure to an organophosphate pesticide (chlorpyrifos; CPF) in an iPSC-derived human three-dimensional (3D) brain model.	Chlorpyrifos	234-246	chromodomain helicase DNA binding protein 8	Homo sapiens	123-166
34259569-4	2021	OBJECTIVES: In this study, we aimed to identify a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 (CHD8) and environmental exposure to an organophosphate pesticide (chlorpyrifos; CPF) in an iPSC-derived human three-dimensional (3D) brain model.	Chlorpyrifos	234-246	chromodomain helicase DNA binding protein 8	Homo sapiens	168-172
34250774-10	2021	Chlorpyrifos (100 mg/kg) alone and in combination with caffeine (40 mg/kg) significantly reduced acetylcholinesterase (AChE) activity.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	119-123
35623197-6	2022	Co-exposure of chlorpyrifos and p,p"-DDE contributed to increased activity of antioxidant enzyme CAT, SOD and GST and excessive MDA generation, and decreased activity of CarE, CYP450 and AChE, compared with either single exposure of them.	Chlorpyrifos	15-27	catalase	Danio rerio	97-100
35334325-3	2022	Under the opted conditions, the linearity was in the range of 1.0-1000.0 ng mL-1 for atrazine and ametryn, 3.0-1500.0 ng mL-1 for tribenuron-methyl, metribuzin, profenofos and chlorpyrifos, 5.0 to 1500.0 ng mL-1 for phosalone, and 5.0-2000.0 ng mL-1 for malation with coefficient of determination (r2) >= 0.9943.	Chlorpyrifos	176-188	L1 cell adhesion molecule	Mus musculus	121-125
35623197-6	2022	Co-exposure of chlorpyrifos and p,p"-DDE contributed to increased activity of antioxidant enzyme CAT, SOD and GST and excessive MDA generation, and decreased activity of CarE, CYP450 and AChE, compared with either single exposure of them.	Chlorpyrifos	15-27	acetylcholinesterase	Danio rerio	187-191
34637829-6	2022	Moreover, chlorpyrifos-induced reductions in heat tolerance (CTmax), acetylcholinesterase (AChE) activity and development time were further magnified by the heat spike.	Chlorpyrifos	10-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-89
35623791-9	2022	When the bioactivity of AChE was inhibited by the organophosphate pesticides (chlorpyrifos as substrate), the reduced production of thiocholine resulted in a decline in photocurrent.	Chlorpyrifos	78-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-28
35623791-10	2022	Under optimal conditions, the structured AChE/GLD-CS/CdCoS2(2)@Ag/ITO sensing platform was successfully achieved for chlorpyrifos detection.	Chlorpyrifos	117-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	41-45
35225412-8	2022	Hepatic CES and FAAH activities were also significantly decreased following CPS exposure regardless of diet.	Chlorpyrifos	76-79	fatty acid amide hydrolase	Mus musculus	16-20
35583593-0	2022	A Pretreatment with Isoorientin Attenuates Redox Disruption, Mitochondrial Impairment, and Inflammation Caused by Chlorpyrifos in a Dopaminergic Cell Line: Involvement of the Nrf2/HO-1 Axis.	Chlorpyrifos	114-126	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
35583593-0	2022	A Pretreatment with Isoorientin Attenuates Redox Disruption, Mitochondrial Impairment, and Inflammation Caused by Chlorpyrifos in a Dopaminergic Cell Line: Involvement of the Nrf2/HO-1 Axis.	Chlorpyrifos	114-126	heme oxygenase 1	Homo sapiens	180-184
35395341-6	2022	Chlorpyrifos, dithianon, and captan inhibited ROS production and TNF-alpha, IL-1beta pro-inflammatory cytokines.	Chlorpyrifos	0-12	tumor necrosis factor	Homo sapiens	65-74
35572106-4	2022	Chlorpyrifos as an acetylcholinesterase inhibitor controls the enzymatic hydrolysis reaction and further regulates the production of thiocholine that could decompose CoOOH nanoflakes into Co2+, resulting in the fluorescence response of AuNC-based hydrogel.	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	19-39
35470462-9	2022	Combined exposure to chlorpyrifos and cyfluthrin exhibited distinct joint action modes in terms of neurobehavior, AChE activity, and neurotransmitter levels, thereby providing an experimental basis for assessing the combined exposure to chlorpyrifos and cyfluthrin"s environmental risk.	Chlorpyrifos	21-33	acetylcholinesterase	Danio rerio	114-118
35151815-7	2022	Ces activity was more sensitive to inhibition than MAGL or FAAH activity following exposure to the lowest CPS concentration.	Chlorpyrifos	106-109	monoglyceride lipase	Rattus norvegicus	51-55
35151815-7	2022	Ces activity was more sensitive to inhibition than MAGL or FAAH activity following exposure to the lowest CPS concentration.	Chlorpyrifos	106-109	fatty-acid amide hydrolase-like	Rattus norvegicus	59-63
35151815-8	2022	Additionally, Ces and MAGL activities in steatotic primary hepatocytes were less sensitive to CPS mediated inhibition than those in normal primary hepatocytes, whereas Ces inhibition was more pronounced in steatotic MCA cells.	Chlorpyrifos	94-97	monoglyceride lipase	Rattus norvegicus	22-26
35583680-5	2022	In this study, the oxidation of malathion, parathion, and chlorpyrifos by n-bromosuccinimide (NBS) was investigated in an approach combining high-performance thin-layer chromatography (HPTLC) with an AChE-I assay.	Chlorpyrifos	58-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	200-204
35583680-10	2022	AChE-I effect recoveries in samples from a stormwater retention basin and receiving stream were between 69 and 92% for malathion, parathion, and chlorpyrifos.	Chlorpyrifos	145-157	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
35294598-1	2022	The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) to account for inter-individual differences in kinetics (HKAF).	Chlorpyrifos	126-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	201-221
35294598-1	2022	The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) to account for inter-individual differences in kinetics (HKAF).	Chlorpyrifos	126-138	acetylcholinesterase (Cartwright blood group)	Homo sapiens	223-227
35500857-10	2022	The IRR for exposure to chlorpyrifos or chlorpyrifos-oxon was 1.27 (95%CI: 1.05-1.52) among all children, and 1.39 (95%CI: 1.07-1.82) among boys.	Chlorpyrifos	24-36	insulin receptor related receptor	Homo sapiens	4-7
35454676-1	2022	Chlorpyrifos (CPF) and 2,4-dichlorophenoxyacetic acid (2,4-D) are insecticides and herbicides which has been widely used on farms.	Chlorpyrifos	0-12	nuclear receptor subfamily 5 group A member 2	Homo sapiens	14-17
35114315-1	2022	The well-known toxicity of chlorpyrifos (CPF) occurs via inhibition of cholinesterase (ChE), but in recent years the detrimental effects of low-dose CPF exposure have been attributed to an unknown non-cholinergic mechanism of action.	Chlorpyrifos	27-39	butyrylcholinesterase	Mus musculus	71-85
35114315-1	2022	The well-known toxicity of chlorpyrifos (CPF) occurs via inhibition of cholinesterase (ChE), but in recent years the detrimental effects of low-dose CPF exposure have been attributed to an unknown non-cholinergic mechanism of action.	Chlorpyrifos	27-39	butyrylcholinesterase	Mus musculus	87-90
34637829-6	2022	Moreover, chlorpyrifos-induced reductions in heat tolerance (CTmax), acetylcholinesterase (AChE) activity and development time were further magnified by the heat spike.	Chlorpyrifos	10-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-95
6205248-0	1984	The interaction of the phosphorothioate insecticides chlorpyrifos and parathion and their oxygen analogues with bovine serum albumin.	Chlorpyrifos	53-65	albumin	Homo sapiens	119-132
2484042-12	1989	It is suggested that a decrease in plasma cholinesterase activity occurs due to chlorpyrifos exposure.	Chlorpyrifos	80-92	butyrylcholinesterase	Homo sapiens	42-56
2459806-1	1988	Following single-pass perfusion of mouse livers in situ with the organophosphate pesticide chlorpyrifos, the cholinesterase inhibitor chlorpyrifos oxon could not be detected in effluent perfusate.	Chlorpyrifos	91-103	butyrylcholinesterase	Mus musculus	109-123
2434058-3	1986	An unsuccessful suicide attempt with the widely used pesticide chlorpyrifos (0,0-diethyl-0-3,5,6,-trichloro-2-pyridyl phosphorothioate) is reported, where prior inhibition of lymphocytic NTE correlates with the delayed development of polyneuropathy.	Chlorpyrifos	63-75	patatin like phospholipase domain containing 6	Homo sapiens	187-190
2579231-1	1985	Mouse liver perfusion studies in situ revealed that the cholinesterase inhibitor chlorpyrifos oxon produced by the liver from the phosphorothioate pesticide chlorpyrifos was quickly detoxified within the liver, thereby preventing it"s exit from the liver in the effluent.	Chlorpyrifos	81-93	butyrylcholinesterase	Mus musculus	56-70
2460000-3	1988	Chlorpyrifos given at a dosage of 0.1 mg/kg to 2 cats reduced whole blood and plasma cholinesterase (Che) activities to values obtained after cats were given doses that induced clinical signs of toxicosis.	Chlorpyrifos	0-12	butyrylcholinesterase	Felis catus	85-99
2460000-3	1988	Chlorpyrifos given at a dosage of 0.1 mg/kg to 2 cats reduced whole blood and plasma cholinesterase (Che) activities to values obtained after cats were given doses that induced clinical signs of toxicosis.	Chlorpyrifos	0-12	butyrylcholinesterase	Felis catus	101-104
6205248-2	1984	In the present study reversible binding of the phosphorothioate insecticides chlorpyrifos and parathion to fatty acid-free bovine serum albumin (BSA) was examined using the technique of equilibrium dialysis.	Chlorpyrifos	77-89	albumin	Homo sapiens	130-143
6184393-2	1982	Leptophos, Chlorpyrifos and diazinon exerted significant inhibition particularly to glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), glutamyltransferase (GT) and lactate dehydrogenase (LDH).	Chlorpyrifos	11-23	glutamic--pyruvic transaminase	Rattus norvegicus	125-154
6200955-3	1984	Under first-order conditions the capacity of mouse hepatic microsomes to detoxify chlorpyrifos oxon exceeded their capacity to generate this potent cholinesterase inhibitor from chlorpyrifos by a factor of 7.6.	Chlorpyrifos	82-94	butyrylcholinesterase	Mus musculus	148-162
6184393-2	1982	Leptophos, Chlorpyrifos and diazinon exerted significant inhibition particularly to glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), glutamyltransferase (GT) and lactate dehydrogenase (LDH).	Chlorpyrifos	11-23	glutamic--pyruvic transaminase	Rattus norvegicus	156-159
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Chlorpyrifos	31-43	acetylcholinesterase	Danio rerio	109-129
94259-4	1979	Treatment with fenthion at 50 mg/kg, 7.4 times the average recommended rate, famphur at 75 mg/kg, 3 times the average rate and chlorpyrifos at 85 mg/kg, 5 times average rate, caused reductions in whole blood cholinesterase activity of 52%, 27% and 47% respectively which were similar to the reductions in cholinesterase activity found in calves treated with methidathion at similar levels above the recommended commercial dose rates.	Chlorpyrifos	127-139	butyrylcholinesterase	Bos taurus	208-222
95070-6	1979	injections of Dursban in a dose of half the LD 50 resulted in a significant increase in serum GOT, GPT and alkaline phosphatase activity and a decrease of cholinesterase.	Chlorpyrifos	14-21	glutamic--pyruvic transaminase	Rattus norvegicus	99-102
95070-6	1979	injections of Dursban in a dose of half the LD 50 resulted in a significant increase in serum GOT, GPT and alkaline phosphatase activity and a decrease of cholinesterase.	Chlorpyrifos	14-21	butyrylcholinesterase	Rattus norvegicus	155-169
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Chlorpyrifos	31-43	acetylcholinesterase	Danio rerio	131-135
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Chlorpyrifos	45-48	acetylcholinesterase	Danio rerio	109-129
33582354-2	2021	Mixtures of atrazine (ATR) and chlorpyrifos (CPF) may elicit synergic effects on the permanent inhibition of acetylcholinesterase (AChE) in certain aquatic organisms, causing severe damage.	Chlorpyrifos	45-48	acetylcholinesterase	Danio rerio	131-135
33480323-0	2021	Disruption of androgen receptor signaling by chlorpyrifos (CPF) and its environmental degradation products: a structural insight.	Chlorpyrifos	45-57	androgen receptor	Homo sapiens	14-31
33930485-0	2021	Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/beta-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment.	Chlorpyrifos	0-12	catenin beta 1	Homo sapiens	99-111
33930485-0	2021	Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/beta-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment.	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-138
33838712-4	2021	This study aims to investigate the effect of CPS on expression of CYP27A1, CYP27B1 and CYP24A1, the enzymes involved in synthesis and metabolism of vitamin D3, in human keratinocytes HaCaT and human fibroblasts BJ.	Chlorpyrifos	45-48	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	66-73
33838712-4	2021	This study aims to investigate the effect of CPS on expression of CYP27A1, CYP27B1 and CYP24A1, the enzymes involved in synthesis and metabolism of vitamin D3, in human keratinocytes HaCaT and human fibroblasts BJ.	Chlorpyrifos	45-48	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	75-82
33838712-4	2021	This study aims to investigate the effect of CPS on expression of CYP27A1, CYP27B1 and CYP24A1, the enzymes involved in synthesis and metabolism of vitamin D3, in human keratinocytes HaCaT and human fibroblasts BJ.	Chlorpyrifos	45-48	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	87-94
33838712-8	2021	Exposure of HaCaT keratinocytes to CPS decreased CYP27A1 mRNA levels, but increased CYP27B1 and CYP24A1 mRNA levels.	Chlorpyrifos	35-38	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	49-56
33838712-8	2021	Exposure of HaCaT keratinocytes to CPS decreased CYP27A1 mRNA levels, but increased CYP27B1 and CYP24A1 mRNA levels.	Chlorpyrifos	35-38	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	84-91
33838712-8	2021	Exposure of HaCaT keratinocytes to CPS decreased CYP27A1 mRNA levels, but increased CYP27B1 and CYP24A1 mRNA levels.	Chlorpyrifos	35-38	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	96-103
33838712-11	2021	Though exposure to CPS decreased CYP27A1 and CYP27B1 mRNA levels, at protein level increasing concentration of CPS and UVB intensity induced expression of CYP27A1 and CYP24A1.	Chlorpyrifos	19-22	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	33-40
33838712-11	2021	Though exposure to CPS decreased CYP27A1 and CYP27B1 mRNA levels, at protein level increasing concentration of CPS and UVB intensity induced expression of CYP27A1 and CYP24A1.	Chlorpyrifos	19-22	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	45-52
33838712-11	2021	Though exposure to CPS decreased CYP27A1 and CYP27B1 mRNA levels, at protein level increasing concentration of CPS and UVB intensity induced expression of CYP27A1 and CYP24A1.	Chlorpyrifos	111-114	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	155-162
33838712-11	2021	Though exposure to CPS decreased CYP27A1 and CYP27B1 mRNA levels, at protein level increasing concentration of CPS and UVB intensity induced expression of CYP27A1 and CYP24A1.	Chlorpyrifos	111-114	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	167-174
33908150-0	2021	Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up-regulation of PARP-1/VEGF.	Chlorpyrifos	32-44	poly (ADP-ribose) polymerase 1	Rattus norvegicus	182-188
33908150-0	2021	Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up-regulation of PARP-1/VEGF.	Chlorpyrifos	32-44	vascular endothelial growth factor A	Rattus norvegicus	189-193
33900070-1	2021	Chlorpyrifos (CPF) is an organophosphate (OP) pesticide that causes acute toxicity by inhibiting acetylcholinesterase (AChE) in the nervous system.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	97-117
33900070-1	2021	Chlorpyrifos (CPF) is an organophosphate (OP) pesticide that causes acute toxicity by inhibiting acetylcholinesterase (AChE) in the nervous system.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	119-123
33900070-1	2021	Chlorpyrifos (CPF) is an organophosphate (OP) pesticide that causes acute toxicity by inhibiting acetylcholinesterase (AChE) in the nervous system.	Chlorpyrifos	14-17	acetylcholinesterase	Mus musculus	97-117
33900070-1	2021	Chlorpyrifos (CPF) is an organophosphate (OP) pesticide that causes acute toxicity by inhibiting acetylcholinesterase (AChE) in the nervous system.	Chlorpyrifos	14-17	acetylcholinesterase	Mus musculus	119-123
33086912-0	2021	IInteraction of organophosphate pesticide chlorpyrifos with alpha-2-macroglobulin: Biophysical and molecular docking approach.	Chlorpyrifos	42-54	alpha-2-macroglobulin	Homo sapiens	60-81
33086912-3	2021	Our work focuses on the structural and functional alteration of alpha2M by chlorpyrifos (CPF), a member of organophosphates.	Chlorpyrifos	75-87	alpha-2-macroglobulin	Homo sapiens	64-71
33086912-3	2021	Our work focuses on the structural and functional alteration of alpha2M by chlorpyrifos (CPF), a member of organophosphates.	Chlorpyrifos	89-92	alpha-2-macroglobulin	Homo sapiens	64-71
34060014-0	2021	Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1alpha pathway.	Chlorpyrifos	17-29	sirtuin 1	Rattus norvegicus	123-128
34060014-0	2021	Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1alpha pathway.	Chlorpyrifos	17-29	telomerase reverse transcriptase	Rattus norvegicus	129-133
34060014-0	2021	Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1alpha pathway.	Chlorpyrifos	17-29	PPARG coactivator 1 alpha	Rattus norvegicus	134-144
33454525-8	2021	In addition, molecular docking revealed that TPHP, TCP, CDP and CPF bound to AChE with glide scores of - 7.8, - 8.3, - 8.1 and - 7.3, respectively.	Chlorpyrifos	64-67	acetylcholinesterase	Danio rerio	77-81
33910290-0	2021	[Factors affecting the recovery of cholinesterase activity in patients with acute chlorpyrifos poisoning].	Chlorpyrifos	82-94	butyrylcholinesterase	Homo sapiens	35-49
33910290-1	2021	Objective: To investigate the related factors affecting the recovery of cholinesterase (ChE) activity in patients with acute chlorpyrifos poisoning.	Chlorpyrifos	125-137	butyrylcholinesterase	Homo sapiens	72-86
33910290-1	2021	Objective: To investigate the related factors affecting the recovery of cholinesterase (ChE) activity in patients with acute chlorpyrifos poisoning.	Chlorpyrifos	125-137	butyrylcholinesterase	Homo sapiens	88-91
33910290-7	2021	Conclusion: The recovery of serum ChE activity in patients with acute chlorpyrifos poisoning is very slow.	Chlorpyrifos	70-82	butyrylcholinesterase	Homo sapiens	34-37
33910290-8	2021	Hemoperfusion can quickly remove chlorpyrifos, its metabolites and inflammatory mediators in the blood, thus effectively promoting the recovery of ChE activity.	Chlorpyrifos	33-45	butyrylcholinesterase	Homo sapiens	147-150
33862360-8	2021	The limit of detection are 2.1 ng mL-1 and 1.7 ng mL-1 for chlorpyrifos and quinalphos, respectively.	Chlorpyrifos	59-71	L1 cell adhesion molecule	Mus musculus	34-46
33862360-8	2021	The limit of detection are 2.1 ng mL-1 and 1.7 ng mL-1 for chlorpyrifos and quinalphos, respectively.	Chlorpyrifos	59-71	L1 cell adhesion molecule	Mus musculus	34-38
33540251-0	2021	Prenatal chlorpyrifos exposure in association with PPARgamma H3K4me3 and DNA methylation levels and child development.	Chlorpyrifos	9-21	peroxisome proliferator activated receptor gamma	Homo sapiens	51-60
33540251-2	2021	Epigenetic regulation of peroxisome proliferator-activated receptor gamma (PPARgamma), such as DNA methylation and trimethylation of lysine 4 of H3 (H3K4me3), may provide a potential mechanism for how fetal growth and development are impacted by chlorpyrifos exposure.	Chlorpyrifos	246-258	peroxisome proliferator activated receptor gamma	Homo sapiens	25-73
33540251-2	2021	Epigenetic regulation of peroxisome proliferator-activated receptor gamma (PPARgamma), such as DNA methylation and trimethylation of lysine 4 of H3 (H3K4me3), may provide a potential mechanism for how fetal growth and development are impacted by chlorpyrifos exposure.	Chlorpyrifos	246-258	peroxisome proliferator activated receptor gamma	Homo sapiens	75-84
33540251-3	2021	The aims of the study were to investigate whether prenatal chlorpyrifos exposure was associated with H3K4me3 and DNA methylation levels of the PPARgamma gene in the placenta and the related effects on birth outcomes and neurodevelopment.	Chlorpyrifos	59-71	peroxisome proliferator activated receptor gamma	Homo sapiens	143-152
33540251-6	2021	RESULTS: After controlling for potential confounders, each unit increase in the natural log-transformed prenatal chlorpyrifos exposure level was associated with an increase in the PPARgamma DNA methylation level (adjusted beta (abeta) = 0.77, p = 0.032) and poorer performance in the cognitive and language domains at 2 years old, especially in boys (abeta = -1.66, p = 0.016, and abeta = -1.79, p = 0.023, respectively).	Chlorpyrifos	113-125	peroxisome proliferator activated receptor gamma	Homo sapiens	180-189
33540251-8	2021	CONCLUSIONS: Our findings suggested that prenatal chlorpyrifos exposure affected PPARgamma DNA methylation levels and performance in the cognitive and language domains.	Chlorpyrifos	50-62	peroxisome proliferator activated receptor gamma	Homo sapiens	81-90
33221011-5	2021	The acetylcholinesterase (AChE) inhibitory was detected by 13 mug/L chlorpyrifos and could be reversed by the co-exposure of 100 and 1000 mug/L anticholinergic agent atropine.	Chlorpyrifos	68-80	acetylcholinesterase	Danio rerio	4-24
33221011-5	2021	The acetylcholinesterase (AChE) inhibitory was detected by 13 mug/L chlorpyrifos and could be reversed by the co-exposure of 100 and 1000 mug/L anticholinergic agent atropine.	Chlorpyrifos	68-80	acetylcholinesterase	Danio rerio	26-30
32440878-0	2020	Chlorpyrifos effects on integrin alpha v and beta 3 in implantation window phase.	Chlorpyrifos	0-12	integrin alpha V	Mus musculus	24-51
33297076-5	2021	Here, we used rotenone and chlorpyrifos to understand the interaction of these pesticides with a metabolic protein, malate dehydrogenase (MDH) and the consequent pesticide-induced cytotoxicity.	Chlorpyrifos	27-39	malic enzyme 1	Homo sapiens	116-136
33297076-5	2021	Here, we used rotenone and chlorpyrifos to understand the interaction of these pesticides with a metabolic protein, malate dehydrogenase (MDH) and the consequent pesticide-induced cytotoxicity.	Chlorpyrifos	27-39	malic enzyme 1	Homo sapiens	138-141
33297076-6	2021	We found that rotenone and chlorpyrifos strongly bind to MDH, interferes with protein folding and triggers alteration in its secondary structure.	Chlorpyrifos	27-39	malic enzyme 1	Homo sapiens	57-60
33297076-8	2021	Rotenone and chlorpyrifos induced structural alterations during MDH refolding resulting in the formation of cytotoxic conformers that generated oxidative stress and reduced cell viability.	Chlorpyrifos	13-25	malic enzyme 1	Homo sapiens	64-67
33383760-0	2020	Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet.	Chlorpyrifos	30-42	apolipoprotein E	Mus musculus	110-114
33383760-2	2020	The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF).	Chlorpyrifos	160-172	apolipoprotein E	Mus musculus	30-46
33383760-2	2020	The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF).	Chlorpyrifos	160-172	apolipoprotein E	Mus musculus	48-52
33383760-2	2020	The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF).	Chlorpyrifos	174-177	apolipoprotein E	Mus musculus	30-46
33383760-2	2020	The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF).	Chlorpyrifos	174-177	apolipoprotein E	Mus musculus	48-52
32683019-3	2020	We exposed foragers to chlorpyrifos, cypermethrin and thiacloprid and assessed the expression of genes after exposure for 24 h, 48 h and 72 h. Chlorpyrifos caused the strongest expressional changes at 24 h characterized by induction of vitellogenin, major royal jelly protein (mrjp) 2 and 3, insulin-like peptide (ilp1), alpha-glucosidase (hbg3) and sima, and down-regulation of buffy.	Chlorpyrifos	143-155	vitellogenin	Apis mellifera	236-248
32683019-3	2020	We exposed foragers to chlorpyrifos, cypermethrin and thiacloprid and assessed the expression of genes after exposure for 24 h, 48 h and 72 h. Chlorpyrifos caused the strongest expressional changes at 24 h characterized by induction of vitellogenin, major royal jelly protein (mrjp) 2 and 3, insulin-like peptide (ilp1), alpha-glucosidase (hbg3) and sima, and down-regulation of buffy.	Chlorpyrifos	143-155	major royal jelly protein 2	Apis mellifera	250-290
32683019-3	2020	We exposed foragers to chlorpyrifos, cypermethrin and thiacloprid and assessed the expression of genes after exposure for 24 h, 48 h and 72 h. Chlorpyrifos caused the strongest expressional changes at 24 h characterized by induction of vitellogenin, major royal jelly protein (mrjp) 2 and 3, insulin-like peptide (ilp1), alpha-glucosidase (hbg3) and sima, and down-regulation of buffy.	Chlorpyrifos	143-155	alpha-glucosidase	Apis mellifera	321-338
32683019-3	2020	We exposed foragers to chlorpyrifos, cypermethrin and thiacloprid and assessed the expression of genes after exposure for 24 h, 48 h and 72 h. Chlorpyrifos caused the strongest expressional changes at 24 h characterized by induction of vitellogenin, major royal jelly protein (mrjp) 2 and 3, insulin-like peptide (ilp1), alpha-glucosidase (hbg3) and sima, and down-regulation of buffy.	Chlorpyrifos	143-155	alpha-glucosidase	Apis mellifera	340-344
32512455-0	2020	Xenobiotic transcription factors CncC and maf regulate expression of CYP321A16 and CYP332A1 that mediate chlorpyrifos resistance in Spodoptera exigua.	Chlorpyrifos	105-117	cap-n-collar	Drosophila melanogaster	33-37
32512455-0	2020	Xenobiotic transcription factors CncC and maf regulate expression of CYP321A16 and CYP332A1 that mediate chlorpyrifos resistance in Spodoptera exigua.	Chlorpyrifos	105-117	maf-S	Drosophila melanogaster	42-45
32512455-4	2020	Here, we investigated the function of CYP321A16 and CYP332A1 in resistance to the organophosphate insecticide, chlorpyrifos and their regulation by the transcription factors CncC and Maf.	Chlorpyrifos	111-123	cap-n-collar	Drosophila melanogaster	174-178
32512455-4	2020	Here, we investigated the function of CYP321A16 and CYP332A1 in resistance to the organophosphate insecticide, chlorpyrifos and their regulation by the transcription factors CncC and Maf.	Chlorpyrifos	111-123	maf-S	Drosophila melanogaster	183-186
32512455-10	2020	These data demonstrate that resistance to chlorpyrifos in S. exigua is conferred by the combined action of CYP321A16 and CYP332A1 and uncovered their regulation by the transcription factors CncC and Maf.	Chlorpyrifos	42-54	cap-n-collar	Drosophila melanogaster	190-194
32512455-10	2020	These data demonstrate that resistance to chlorpyrifos in S. exigua is conferred by the combined action of CYP321A16 and CYP332A1 and uncovered their regulation by the transcription factors CncC and Maf.	Chlorpyrifos	42-54	maf-S	Drosophila melanogaster	199-202
32768820-0	2020	Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis.	Chlorpyrifos	0-12	phosphatase and tensin homolog	Homo sapiens	82-86
32768820-0	2020	Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis.	Chlorpyrifos	0-12	AKT serine/threonine kinase 1	Homo sapiens	92-95
32526215-0	2020	Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor.	Chlorpyrifos	83-95	aryl hydrocarbon receptor	Homo sapiens	122-147
32413749-0	2020	In vitro oxidation promoted by chlorpyrifos residues on myosin and chicken breast proteins.	Chlorpyrifos	31-43	myosin, heavy chain 7B, cardiac muscle, beta	Gallus gallus	56-62
32413749-4	2020	Myosin protein was exposed to diazinon and chlorpyrifos showing an increase in its oxidation by increasing times, especially with chlorpyrifos.	Chlorpyrifos	43-55	myosin, heavy chain 7B, cardiac muscle, beta	Gallus gallus	0-6
32413749-4	2020	Myosin protein was exposed to diazinon and chlorpyrifos showing an increase in its oxidation by increasing times, especially with chlorpyrifos.	Chlorpyrifos	130-142	myosin, heavy chain 7B, cardiac muscle, beta	Gallus gallus	0-6
32976529-0	2020	Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.	Chlorpyrifos	71-83	paraoxonase 1	Mus musculus	87-91
32976529-2	2020	Mutant mice lacking the gene for paraoxonase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and were hypothesized to be more vulnerable to social behavior deficits induced by exposure to chlorpyrifos during gestation.	Chlorpyrifos	101-113	paraoxonase 1	Mus musculus	33-45
32976529-2	2020	Mutant mice lacking the gene for paraoxonase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and were hypothesized to be more vulnerable to social behavior deficits induced by exposure to chlorpyrifos during gestation.	Chlorpyrifos	101-113	paraoxonase 1	Mus musculus	47-51
32976529-2	2020	Mutant mice lacking the gene for paraoxonase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and were hypothesized to be more vulnerable to social behavior deficits induced by exposure to chlorpyrifos during gestation.	Chlorpyrifos	210-222	paraoxonase 1	Mus musculus	33-45
32976529-2	2020	Mutant mice lacking the gene for paraoxonase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and were hypothesized to be more vulnerable to social behavior deficits induced by exposure to chlorpyrifos during gestation.	Chlorpyrifos	210-222	paraoxonase 1	Mus musculus	47-51
32387648-0	2020	Postnatal exposure to low doses of Chlorpyrifos induces long-term effects on 5C-SRTT learning and performance, cholinergic and GABAergic systems and BDNF expression.	Chlorpyrifos	35-47	brain-derived neurotrophic factor	Rattus norvegicus	149-153
32171938-6	2020	Accordingly, we hypothesized that CPF or its metabolite chlorpyrifos-oxon (CPFO) could induce cell viability promotion in MCF-7 and MDA-MB-231 cell lines, through mechanisms related to ERalpha, AhR, and KIAA1363, after 24 h and 14 days treatment.	Chlorpyrifos	34-37	estrogen receptor 1	Homo sapiens	185-192
32481206-0	2020	TCP structure intensified the chlorpyrifos-induced decrease in testosterone synthesis via LH-LHR-PKA-CREB-Star pathway.	Chlorpyrifos	30-42	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	93-96
32481206-0	2020	TCP structure intensified the chlorpyrifos-induced decrease in testosterone synthesis via LH-LHR-PKA-CREB-Star pathway.	Chlorpyrifos	30-42	cAMP responsive element binding protein 1	Homo sapiens	101-105
32481206-0	2020	TCP structure intensified the chlorpyrifos-induced decrease in testosterone synthesis via LH-LHR-PKA-CREB-Star pathway.	Chlorpyrifos	30-42	steroidogenic acute regulatory protein	Homo sapiens	106-110
32171938-6	2020	Accordingly, we hypothesized that CPF or its metabolite chlorpyrifos-oxon (CPFO) could induce cell viability promotion in MCF-7 and MDA-MB-231 cell lines, through mechanisms related to ERalpha, AhR, and KIAA1363, after 24 h and 14 days treatment.	Chlorpyrifos	34-37	aryl hydrocarbon receptor	Homo sapiens	194-197
32057829-2	2020	Both C57BL/6 and humanised apoE4 female mice were transiently exposed to subclinical doses (0 or 1 mg/kg body weight) of the cholinesterase inhibitor chlorpyrifos (CPF), a widely-used pesticide, from postnatal days 10 to 15.	Chlorpyrifos	150-162	butyrylcholinesterase	Mus musculus	125-139
32278836-4	2020	The results revealed that sublethal exposure of chlorpyrifos caused significant (p < 0.05) reduction in lysozyme, ACH50, phagocytic, and anti-protease activities whereas there was significant (p < 0.05) increase in NBT, MPO and hemagglutination levels along with serum IgM concentration.	Chlorpyrifos	48-60	myeloperoxidase	Homo sapiens	220-223
32096903-0	2020	Aerobic exercise and eugenol supplementation ameliorated liver injury induced by chlorpyrifos via modulation acetylcholinesterase activation and antioxidant defense.	Chlorpyrifos	81-93	acetylcholinesterase	Rattus norvegicus	109-129
32096903-8	2020	The result of this study show that consumption of CPF alone, caused collagen deposition, increased apoptosis, tumor necrosis factor alpha, malondialdehyde, and decreased catalase, superoxide dismutase, acetylcholinesterase (AChE) compared to control and exercise groups (healthy groups) in liver tissue (P   .05).	Chlorpyrifos	50-53	acetylcholinesterase	Rattus norvegicus	202-222
32096903-8	2020	The result of this study show that consumption of CPF alone, caused collagen deposition, increased apoptosis, tumor necrosis factor alpha, malondialdehyde, and decreased catalase, superoxide dismutase, acetylcholinesterase (AChE) compared to control and exercise groups (healthy groups) in liver tissue (P   .05).	Chlorpyrifos	50-53	acetylcholinesterase	Rattus norvegicus	224-228
32213749-7	2020	Chlorpyrifos is a potent inhibitor of CYP1A with Ki 0.24 microM and moderately inhibited CYP2C or 3A with Ki values of 84.8 and 77.7 microM, respectively.	Chlorpyrifos	0-12	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	89-94
32213749-9	2020	From these results, it is concluded that both fenitrothion and chlorpyrifos may increase the toxicity of chemicals in environmental living organisms through their potent inhibitory effects on these CYP activities, but dichlorvos and trichlorfon may not.	Chlorpyrifos	63-75	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	198-201
32156659-6	2020	Hexachlorobenzene (HCB) and chlorpyrifos (CPF), both weak AhR ligands, promote cell proliferation and migration in breast cancer cells, as well as tumor growth in rat models.	Chlorpyrifos	28-40	aryl hydrocarbon receptor	Rattus norvegicus	58-61
32156659-6	2020	Hexachlorobenzene (HCB) and chlorpyrifos (CPF), both weak AhR ligands, promote cell proliferation and migration in breast cancer cells, as well as tumor growth in rat models.	Chlorpyrifos	42-45	aryl hydrocarbon receptor	Rattus norvegicus	58-61
31965510-1	2020	Chlorpyrifos is an organophosphate pesticide whose exposure leads to inhibition of acetylcholinesterase (AChE) enzyme and induces oxidative stress, inflammation, and neurotoxicity.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	83-103
31965510-1	2020	Chlorpyrifos is an organophosphate pesticide whose exposure leads to inhibition of acetylcholinesterase (AChE) enzyme and induces oxidative stress, inflammation, and neurotoxicity.	Chlorpyrifos	0-12	acetylcholinesterase	Mus musculus	105-109
32290125-1	2020	Chlorpyrifos, an acetylcholinesterase inhibitor (ACI), is one of the most widely used insecticides in the world, and is generally recognized to be a moderate human neurotoxin.	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	17-37
31841723-9	2020	Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific.	Chlorpyrifos	113-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
31841723-9	2020	Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific.	Chlorpyrifos	113-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
31841723-9	2020	Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific.	Chlorpyrifos	113-125	butyrylcholinesterase	Homo sapiens	52-57
32006337-8	2020	In conclusion, chlorpyrifos and cypermethrin revealed antagonistic inhibitions on the brain MAO-A and AChE gene regulation through neurotransmission deteriorations and oxidative damage, which could describe their contributions in the neuropathological progressions.	Chlorpyrifos	15-27	monoamine oxidase A	Rattus norvegicus	92-97
32006337-2	2020	Monoamine oxidase-A (MAO-A) and acetylcholinesterase (AChE) gene expression in the rat brain were evaluated after independent and combined intoxications with chlorpyrifos and cypermethrin.	Chlorpyrifos	158-170	acetylcholinesterase	Rattus norvegicus	21-52
32006337-8	2020	In conclusion, chlorpyrifos and cypermethrin revealed antagonistic inhibitions on the brain MAO-A and AChE gene regulation through neurotransmission deteriorations and oxidative damage, which could describe their contributions in the neuropathological progressions.	Chlorpyrifos	15-27	acetylcholinesterase	Rattus norvegicus	102-106
32006337-5	2020	As compared to the control group, intoxications with chlorpyrifos and/or cypermethrin revealed significant (P &lt; 0.05) declines in the levels of brain neurotransmitters (dopamine and serotonin) plus the enzymatic activities of MAO-A, AChE and sodium-potassium adenosine triphosphatase.	Chlorpyrifos	53-65	monoamine oxidase A	Rattus norvegicus	229-234
32006337-5	2020	As compared to the control group, intoxications with chlorpyrifos and/or cypermethrin revealed significant (P &lt; 0.05) declines in the levels of brain neurotransmitters (dopamine and serotonin) plus the enzymatic activities of MAO-A, AChE and sodium-potassium adenosine triphosphatase.	Chlorpyrifos	53-65	acetylcholinesterase	Rattus norvegicus	236-240
31889325-0	2020	A computational insight into the molecular interactions of chlorpyrifos and its degradation products with the human progesterone receptor leading to endocrine disruption.	Chlorpyrifos	59-71	progesterone receptor	Homo sapiens	116-137
32031197-5	2020	In the presence of OPs, the AChE-catalyzed hydrolysis of indoxyl acetate is blocked, and then the silver deposition on the gold electrode declines, leading to a remarkable decrease in the LSV response and, thus producing a large signal output for the ultrasensitive detection of chlorpyrifos, a proof-of-concept OP in this work.	Chlorpyrifos	279-291	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32
32180031-7	2020	The linear dynamic range was in the ranges 1-30 and 1-70 mug L-1 with regression coefficients of 0.9973 and 0.9956 for ethion and chlorpyrifos, respectively.	Chlorpyrifos	130-142	immunoglobulin kappa variable 1-16	Homo sapiens	61-64
32180031-8	2020	The limit of detection was 0.09 and 0.21 mug L-1 for ethion and chlorpyrifos, respectively.	Chlorpyrifos	64-76	immunoglobulin kappa variable 1-16	Homo sapiens	45-48
31889325-2	2020	Based on earlier epidemiologic reports, which indicate that CPF might interfere with the progesterone signaling pathway and can affect conception, the present study was undertaken to evaluate the binding interaction of CPF with the human progesterone receptor (hPR).	Chlorpyrifos	60-63	progesterone receptor	Homo sapiens	238-259
31889325-2	2020	Based on earlier epidemiologic reports, which indicate that CPF might interfere with the progesterone signaling pathway and can affect conception, the present study was undertaken to evaluate the binding interaction of CPF with the human progesterone receptor (hPR).	Chlorpyrifos	219-222	progesterone receptor	Homo sapiens	238-259
31889325-2	2020	Based on earlier epidemiologic reports, which indicate that CPF might interfere with the progesterone signaling pathway and can affect conception, the present study was undertaken to evaluate the binding interaction of CPF with the human progesterone receptor (hPR).	Chlorpyrifos	219-222	haptoglobin-related protein	Homo sapiens	261-264
31889325-6	2020	Docking studies revealed that CPF, CPYO, and DEC were able to involve important interacting amino acid residues of the hPR during molecular interactions and are capable of competing with progesterone.	Chlorpyrifos	30-33	haptoglobin-related protein	Homo sapiens	119-122
31889325-7	2020	Thus, CPF and its degradation products can act as potential xenoligands for the hPR and can disrupt normal progesterone signaling pathway.	Chlorpyrifos	6-9	haptoglobin-related protein	Homo sapiens	80-83
31931040-0	2020	Inhibition of fatty acid amide hydrolase by chlorpyrifos in juvenile rats results in altered exploratory and social behavior as adolescents.	Chlorpyrifos	44-56	fatty-acid amide hydrolase-like	Rattus norvegicus	14-40
32700837-11	2020	The limit of detection of the assay was 422.6 ng mL-1 for methomyl and was 339.8 ng mL-1 for chlorpyrifos.	Chlorpyrifos	93-105	L1 cell adhesion molecule	Mus musculus	84-88
31609053-5	2020	Through this inhibition effect the platform can realize a detection limit for chlorpyrifos of 0.01 ng mL-1 , much lower than the maximum residue limit (10 ppb) permitted by the U.S. Environmental Protection Agency.	Chlorpyrifos	78-90	L1 cell adhesion molecule	Mus musculus	102-106
31807802-11	2020	Meanwhile, plasma haptoglobin, colon weights, and luminal immunoglobulin G levels were higher in CPF-exposed groups.	Chlorpyrifos	97-100	haptoglobin	Mus musculus	18-29
31622728-8	2020	APOE and CPF influenced cerebral SCFAs, with APOE3 genotype showing the highest levels of acetic, propionic and butyric acids and CPF exposure inducing the highest levels of isovaleric and 4-methylvaleric acids.	Chlorpyrifos	130-133	apolipoprotein E	Mus musculus	0-4
31473287-0	2019	APOE genetic background and sex confer different vulnerabilities to postnatal chlorpyrifos exposure and modulate the response to cholinergic drugs.	Chlorpyrifos	78-90	apolipoprotein E	Mus musculus	0-4
31560517-5	2019	The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity.	Chlorpyrifos	237-249	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-51
31560517-5	2019	The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity.	Chlorpyrifos	237-249	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-57
31560517-5	2019	The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity.	Chlorpyrifos	237-249	acetylcholinesterase (Cartwright blood group)	Homo sapiens	310-314
31472362-0	2019	Exposure to chlorpyrifos at different ages triggers APOE genotype-specific responses in social behavior, body weight and hypothalamic gene expression.	Chlorpyrifos	12-24	apolipoprotein E	Mus musculus	52-56
31472362-1	2019	To date, we have shown that apolipoprotein E (APOE) polymorphisms differentially modulate the neurobehavioral and metabolic effects of chlorpyrifos (CPF), a widely used pesticide, which is detected as residue in food.	Chlorpyrifos	135-147	apolipoprotein E	Mus musculus	28-44
31472362-1	2019	To date, we have shown that apolipoprotein E (APOE) polymorphisms differentially modulate the neurobehavioral and metabolic effects of chlorpyrifos (CPF), a widely used pesticide, which is detected as residue in food.	Chlorpyrifos	135-147	apolipoprotein E	Mus musculus	46-50
31472362-1	2019	To date, we have shown that apolipoprotein E (APOE) polymorphisms differentially modulate the neurobehavioral and metabolic effects of chlorpyrifos (CPF), a widely used pesticide, which is detected as residue in food.	Chlorpyrifos	149-152	apolipoprotein E	Mus musculus	28-44
31472362-1	2019	To date, we have shown that apolipoprotein E (APOE) polymorphisms differentially modulate the neurobehavioral and metabolic effects of chlorpyrifos (CPF), a widely used pesticide, which is detected as residue in food.	Chlorpyrifos	149-152	apolipoprotein E	Mus musculus	46-50
31136966-1	2019	Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-184
31358233-5	2019	Extraction recoveries for 5 ng mL-1 of diazinon, phosalone and chlorpyrifos were 99%, 98% and 96%, respectively; with relative standard deviations values were lower than 4.6% for five replications of extraction.	Chlorpyrifos	63-75	L1 cell adhesion molecule	Mus musculus	31-35
31136966-1	2019	Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE).	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	186-190
31136966-1	2019	Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE).	Chlorpyrifos	14-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-184
31136966-1	2019	Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE).	Chlorpyrifos	14-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	186-190
31278555-0	2019	Oriented assembly of surface plasmon resonance biosensor through staphylococcal protein A for the chlorpyrifos detection.	Chlorpyrifos	98-110	surfactant protein A1	Homo sapiens	65-89
31278555-2	2019	In this covalent-orientated strategy, staphylococcal protein A (SPA) was first covalently bound to the surface for monitoring chlorpyrifos residue, with subsequent binding of the antibody in an orientated fashion via its fragment crystallizable (Fc) region.	Chlorpyrifos	126-138	surfactant protein A1	Homo sapiens	38-62
31278555-2	2019	In this covalent-orientated strategy, staphylococcal protein A (SPA) was first covalently bound to the surface for monitoring chlorpyrifos residue, with subsequent binding of the antibody in an orientated fashion via its fragment crystallizable (Fc) region.	Chlorpyrifos	126-138	surfactant protein A1	Homo sapiens	64-67
31278555-3	2019	Consequently, the SPA-modified biosensor exhibited a satisfactory specificity and a low detection limit of 0.056 ng mL-1 for chlorpyrifos, with a linear detection range of 0.25-50.0 ng mL-1.	Chlorpyrifos	125-137	surfactant protein A1	Homo sapiens	18-21
29372658-5	2019	About 96 h exposure to sublethal concentrations (0, 12.0 and 25.0 mug/L) of the commercial formulation (20% EC) of chlorpyrifos reduced the level of hepatic glycogen, activities of alkaline phosphatase, acetylcholinesterase, and catalase in liver and elevated the level of plasma glucose and activities of hepatic acid phosphatase, aspartate aminotransferase, and alanine aminotransferase in O. niloticus.	Chlorpyrifos	115-127	catalase	Oreochromis niloticus	181-237
30815923-0	2019	Molecular interactions of chlorpyrifos and its environmental degradation products with human sex hormone-binding globulin: an in silico study.	Chlorpyrifos	26-38	sex hormone binding globulin	Homo sapiens	93-121
31400774-0	2019	Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression.	Chlorpyrifos	40-52	paraoxonase 1	Rattus norvegicus	90-103
31400774-2	2019	The probable amelioration role of propolis is gauged against the cardiotoxic effects of chlorpyrifos in the diabetic rats through paraoxonase-1 (PON1) and xanthine oxidase (XO) genes dysregulation.	Chlorpyrifos	88-100	paraoxonase 1	Rattus norvegicus	130-143
31400774-2	2019	The probable amelioration role of propolis is gauged against the cardiotoxic effects of chlorpyrifos in the diabetic rats through paraoxonase-1 (PON1) and xanthine oxidase (XO) genes dysregulation.	Chlorpyrifos	88-100	paraoxonase 1	Rattus norvegicus	145-149
31400774-7	2019	Although the cardiac acetylcholinesterase, total thiols, and PON1 significantly reduced after diabetic and/or chlorpyrifos gavage, the protein carbonyl, superoxide dismutase, catalase, and XO significantly elevated.	Chlorpyrifos	110-122	paraoxonase 1	Rattus norvegicus	61-65
30990955-12	2019	In chlorpyrifos-treated animals, we have observed a significant decrease in the protein expression level of Bcl-2, but a remarkable increase in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 in both cerebrum and cerebellum.	Chlorpyrifos	3-15	BCL2, apoptosis regulator	Rattus norvegicus	108-113
30990955-12	2019	In chlorpyrifos-treated animals, we have observed a significant decrease in the protein expression level of Bcl-2, but a remarkable increase in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 in both cerebrum and cerebellum.	Chlorpyrifos	3-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	169-172
30990955-12	2019	In chlorpyrifos-treated animals, we have observed a significant decrease in the protein expression level of Bcl-2, but a remarkable increase in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 in both cerebrum and cerebellum.	Chlorpyrifos	3-15	caspase 8	Rattus norvegicus	188-197
30990955-12	2019	In chlorpyrifos-treated animals, we have observed a significant decrease in the protein expression level of Bcl-2, but a remarkable increase in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 in both cerebrum and cerebellum.	Chlorpyrifos	3-15	caspase 9	Rattus norvegicus	203-212
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Chlorpyrifos	20-32	BCL2, apoptosis regulator	Rattus norvegicus	127-132
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Chlorpyrifos	20-32	BCL2 associated X, apoptosis regulator	Rattus norvegicus	188-191
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Chlorpyrifos	20-32	caspase 8	Rattus norvegicus	207-216
30990955-13	2019	Interestingly, when chlorpyrifos-treated animals were supplemented with quercetin, a significant increase in the expression of Bcl-2 and an appreciable decline in the expression levels of Bax, cytochrome c, caspase-8, and caspase-9 was observed.	Chlorpyrifos	20-32	caspase 9	Rattus norvegicus	222-231
31082780-5	2019	In relation to environmental risk assessment, the concentrations of most OPPs in water and sediments from the Volturno River and its estuary were lower than guideline values, but the mean concentration of chlorpyrifos (5.41 ng L-1) in the Volturno River and Estuary has been shown that the ecological integrity of the river watercourse is possibly at risk.	Chlorpyrifos	205-217	immunoglobulin kappa variable 1-16	Homo sapiens	227-230
31214721-0	2019	Physiologically based kinetic modelling-facilitated reverse dosimetry to predict in vivo red blood cell acetylcholinesterase inhibition following exposure to chlorpyrifos in the Caucasian and Chinese population.	Chlorpyrifos	158-170	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-124
31214721-2	2019	The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population.	Chlorpyrifos	184-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-162
31214721-2	2019	The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population.	Chlorpyrifos	184-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
31214721-2	2019	The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population.	Chlorpyrifos	198-201	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-162
31214721-2	2019	The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population.	Chlorpyrifos	198-201	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
30835941-0	2019	Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181/SIRT1/PGC-1alpha/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells: Implication for association between chlorpyrifos and Parkinson"s disease.	Chlorpyrifos	0-12	sirtuin 1	Homo sapiens	116-121
30835941-0	2019	Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181/SIRT1/PGC-1alpha/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells: Implication for association between chlorpyrifos and Parkinson"s disease.	Chlorpyrifos	0-12	PPARG coactivator 1 alpha	Homo sapiens	122-132
30835941-0	2019	Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181/SIRT1/PGC-1alpha/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells: Implication for association between chlorpyrifos and Parkinson"s disease.	Chlorpyrifos	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
30835941-0	2019	Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181/SIRT1/PGC-1alpha/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells: Implication for association between chlorpyrifos and Parkinson"s disease.	Chlorpyrifos	230-242	sirtuin 1	Homo sapiens	116-121
30835941-14	2019	CONCLUSIONS: Chlorpyrifos could inhibit cell proliferation, activate cell pyroptosis and increase susceptibility on oxidative stress-induced toxicity by elevating miR-181 through down-regulation of the SIRT1/PGC-1alpha/Nrf2 pathway in human neuroblastoma SH-SY5Y cells.	Chlorpyrifos	13-25	sirtuin 1	Homo sapiens	202-207
30835941-14	2019	CONCLUSIONS: Chlorpyrifos could inhibit cell proliferation, activate cell pyroptosis and increase susceptibility on oxidative stress-induced toxicity by elevating miR-181 through down-regulation of the SIRT1/PGC-1alpha/Nrf2 pathway in human neuroblastoma SH-SY5Y cells.	Chlorpyrifos	13-25	PPARG coactivator 1 alpha	Homo sapiens	208-218
30835941-14	2019	CONCLUSIONS: Chlorpyrifos could inhibit cell proliferation, activate cell pyroptosis and increase susceptibility on oxidative stress-induced toxicity by elevating miR-181 through down-regulation of the SIRT1/PGC-1alpha/Nrf2 pathway in human neuroblastoma SH-SY5Y cells.	Chlorpyrifos	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	219-223
30529921-3	2019	Chlorpyrifos was completely removed within 300 s under the following optimum conditions: [chlorpyrifos]0 = 1 muM, [Fe(VI)]0:[chlorpyrifos]0 = 100:1, T = 25  C, and pH = 7.0.	Chlorpyrifos	0-12	latexin	Homo sapiens	109-112
30758894-0	2019	Nrf2 mediates the protective effect of edaravone after chlorpyrifos-induced nervous system toxicity.	Chlorpyrifos	55-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
31193297-0	2019	Zn2+ and Cd2+ assisted photo-catalytic degradation of chlorpyrifos in soil.	Chlorpyrifos	54-66	CD2 molecule	Homo sapiens	9-12
31193297-1	2019	The Cd2+ and Zn2+ assisted photo-catalytic degradation of soil incorporated chlorpyrifos (CLP) was reported in current study.	Chlorpyrifos	76-88	CD2 molecule	Homo sapiens	4-7
30859069-0	2019	Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos.	Chlorpyrifos	96-108	caspase 3	Rattus norvegicus	56-65
30656380-0	2019	Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype.	Chlorpyrifos	101-113	apolipoprotein E	Mus musculus	149-165
30656380-0	2019	Learning, memory and the expression of cholinergic components in mice are modulated by the pesticide chlorpyrifos depending upon age at exposure and apolipoprotein E (APOE) genotype.	Chlorpyrifos	101-113	apolipoprotein E	Mus musculus	167-171
30656380-1	2019	Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide.	Chlorpyrifos	189-201	apolipoprotein E	Mus musculus	21-37
30656380-1	2019	Polymorphisms of the apolipoprotein E (APOE) gene differentially affect neurobiological functions and cognitive performance and confer different vulnerabilities to subclinical exposures to chlorpyrifos (CPF), a pesticide used worldwide.	Chlorpyrifos	189-201	apolipoprotein E	Mus musculus	39-43
30747009-9	2019	Further, chlorpyrifos exposure significantly elevated the levels of lipid peroxidation and protein carbonyl contents as well as the activities of catalase, superoxide dismutase, which were interestingly found to be decreased following co-treatment with quercetin.	Chlorpyrifos	9-21	catalase	Rattus norvegicus	146-154
30458229-7	2019	At this time (24 h), chlorpyrifos decreased plasma butyrylcholinesterase (BChE) activity and hippocampal, striatal and prefrontal cortical AChE activity in rats.	Chlorpyrifos	21-33	butyrylcholinesterase	Rattus norvegicus	51-72
30227346-0	2019	Ligand free surface of CdS nanoparticles enhances the energy transfer efficiency on interacting with Eosin Y dye - Helping in the sensing of very low level of chlorpyrifos in water.	Chlorpyrifos	159-171	CDP-diacylglycerol synthase 1	Homo sapiens	23-26
30765052-0	2019	Chlorpyrifos stimulates expression of vitamin D3 receptor in skin cells irradiated with UVB.	Chlorpyrifos	0-12	vitamin D receptor	Homo sapiens	38-57
30765052-3	2019	Thus, the aim of this study was to investigate the effect of chlorpyrifos, on the expression of vitamin D3 receptor (VDR) in human keratinocytes cell line HaCaT and fibroblasts cell line BJ.	Chlorpyrifos	61-73	vitamin D receptor	Homo sapiens	96-115
30765052-3	2019	Thus, the aim of this study was to investigate the effect of chlorpyrifos, on the expression of vitamin D3 receptor (VDR) in human keratinocytes cell line HaCaT and fibroblasts cell line BJ.	Chlorpyrifos	61-73	vitamin D receptor	Homo sapiens	117-120
30458229-7	2019	At this time (24 h), chlorpyrifos decreased plasma butyrylcholinesterase (BChE) activity and hippocampal, striatal and prefrontal cortical AChE activity in rats.	Chlorpyrifos	21-33	butyrylcholinesterase	Rattus norvegicus	74-78
30458229-14	2019	Our results suggest that acute chlorpyrifos poisoning induces a transient depressive-like behaviour possible related to hippocampal AChE inhibition.	Chlorpyrifos	31-43	acetylcholinesterase	Rattus norvegicus	132-136
30278244-0	2018	Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner.	Chlorpyrifos	22-34	apolipoprotein E	Mus musculus	129-133
30864424-2	2018	Recently, we reported the ameliorative role of 6-gingerol-rich fraction from Zingiber officinale (Ginger, GRF) on the chlorpyrifos-induced toxicity in rats.	Chlorpyrifos	118-130	growth hormone releasing hormone	Rattus norvegicus	106-109
30224706-2	2018	Exposure to a variety of toxicants including dioxin, di(2-ethylhexyl) phthalate, 6:2 chlorinated polyfluorinated ether sulfonate, and chlorpyrifos results in the downregulation of tetrapod Sox9 and/or zebrafish sox9b.	Chlorpyrifos	134-146	SRY-box transcription factor 9b	Danio rerio	211-216
30497708-0	2018	A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3beta-Nrf2 signaling pathway.	Chlorpyrifos	45-57	glycogen synthase kinase 3 beta	Rattus norvegicus	115-123
30497708-0	2018	A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3beta-Nrf2 signaling pathway.	Chlorpyrifos	45-57	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-128
30497708-6	2018	The results revealed that CPF-treated rats suffered from severe deterioration of spatial and non-spatial memory functions with low activities of antioxidant enzymes and acetylcholinesterase (AChE).	Chlorpyrifos	26-29	acetylcholinesterase	Rattus norvegicus	169-189
30497708-6	2018	The results revealed that CPF-treated rats suffered from severe deterioration of spatial and non-spatial memory functions with low activities of antioxidant enzymes and acetylcholinesterase (AChE).	Chlorpyrifos	26-29	acetylcholinesterase	Rattus norvegicus	191-195
29939281-6	2018	Furthermore, the mRNA level of Cs-mMnSOD was strongly upregulated (more than twofold increase) following exposure to low and high temperatures (4, 30 and 35 C), insecticides (chlorpyrifos and chlorantraniliprole), and chemical reagents (cumene hydroperoxide, paraquat, H2O2 and CdCl2), but slightly elevated (less than twofold increase) in response to 8 C, abamectin and CuSO4.	Chlorpyrifos	175-187	superoxide dismutase 2, mitochondrial	Mus musculus	34-40
29889221-4	2018	Chlorpyrifos alone and the mixture of clothianidin + chlorpyrifos significantly suppressed esterase (EST) activity, while most treatments of individual pesticides and mixtures had no effect on EST and glutathione S-transferase (GST) activities.	Chlorpyrifos	0-12	juvenile hormone esterase	Apis mellifera	91-99
29939342-2	2018	Although the canonical mechanism of OP neurotoxicity is inhibition of acetylcholinesterase (AChE), it was previously reported that the OP chlorpyrifos (CPF) causes airway hyperreactivity (AHR) in guinea pigs at levels that do not inhibit lung or brain AChE.	Chlorpyrifos	152-155	acetylcholinesterase	Cavia porcellus	252-256
29859868-0	2018	Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events.	Chlorpyrifos	26-38	signal transducer and activator of transcription 1	Homo sapiens	47-52
29859868-8	2018	Interestingly, overexpression of non-phosphorylatable STAT1 mutants (STAT1Y701F and STAT1S727A) but not STAT1 WT construct attenuated the cleavage of PKCdelta and ultimately cell death in CPF-treated cells.	Chlorpyrifos	188-191	signal transducer and activator of transcription 1	Homo sapiens	54-59
29859868-8	2018	Interestingly, overexpression of non-phosphorylatable STAT1 mutants (STAT1Y701F and STAT1S727A) but not STAT1 WT construct attenuated the cleavage of PKCdelta and ultimately cell death in CPF-treated cells.	Chlorpyrifos	188-191	signal transducer and activator of transcription 1	Homo sapiens	69-74
29859868-8	2018	Interestingly, overexpression of non-phosphorylatable STAT1 mutants (STAT1Y701F and STAT1S727A) but not STAT1 WT construct attenuated the cleavage of PKCdelta and ultimately cell death in CPF-treated cells.	Chlorpyrifos	188-191	protein kinase C delta	Homo sapiens	150-158
29859868-10	2018	Finally, oral administration of CPF (5 mg/kg) in postnatal rats (PNDs 27-61) induced motor deficits, and nigrostriatal dopaminergic neurodegeneration with a concomitant induction of STAT1-dependent proapoptotic cell signaling events.	Chlorpyrifos	32-35	signal transducer and activator of transcription 1	Rattus norvegicus	182-187
30200437-3	2018	The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse.	Chlorpyrifos	30-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
30200437-3	2018	The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse.	Chlorpyrifos	44-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
29889221-4	2018	Chlorpyrifos alone and the mixture of clothianidin + chlorpyrifos significantly suppressed esterase (EST) activity, while most treatments of individual pesticides and mixtures had no effect on EST and glutathione S-transferase (GST) activities.	Chlorpyrifos	0-12	juvenile hormone esterase	Apis mellifera	101-104
29889221-4	2018	Chlorpyrifos alone and the mixture of clothianidin + chlorpyrifos significantly suppressed esterase (EST) activity, while most treatments of individual pesticides and mixtures had no effect on EST and glutathione S-transferase (GST) activities.	Chlorpyrifos	53-65	juvenile hormone esterase	Apis mellifera	91-99
29889221-4	2018	Chlorpyrifos alone and the mixture of clothianidin + chlorpyrifos significantly suppressed esterase (EST) activity, while most treatments of individual pesticides and mixtures had no effect on EST and glutathione S-transferase (GST) activities.	Chlorpyrifos	53-65	juvenile hormone esterase	Apis mellifera	101-104
29626809-0	2018	Cypermethrin, chlorpyrifos, deltamethrin, and imidacloprid exposure up-regulates the mRNA and protein levels of bdnf and c-fos in the brain of adult zebrafish (Danio rerio).	Chlorpyrifos	14-26	brain-derived neurotrophic factor	Danio rerio	112-116
30032362-5	2018	Under the optimized conditions, the limits of detection (at S/N = 3; for n = 10) are 0.4 and 0.6 ng mL-1 for diazinon and chloropyrifos, respectively.	Chlorpyrifos	122-135	L1 cell adhesion molecule	Mus musculus	100-104
29773342-5	2018	The calibration curves were linear in the ranges of 0.1-20 and 0.05-20 mug L-1 with determination coefficients (R2) of 0.9976 and 0.9928 for malathion and chlorpyrifos, respectively.	Chlorpyrifos	155-167	immunoglobulin kappa variable 1-16	Homo sapiens	75-78
29773342-6	2018	The limits of detection of 0.032 and 0.019 mug L-1 and the limits of quantification of 0.1 and 0.05 mug L-1 were found for malathion and chlorpyrifos, respectively.	Chlorpyrifos	137-149	immunoglobulin kappa variable 1-16	Homo sapiens	104-107
29626809-0	2018	Cypermethrin, chlorpyrifos, deltamethrin, and imidacloprid exposure up-regulates the mRNA and protein levels of bdnf and c-fos in the brain of adult zebrafish (Danio rerio).	Chlorpyrifos	14-26	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	121-126
29626809-1	2018	The aim of the present study is to investigate the toxicity effects of frequently used pesticides, involving cypermethrin, deltamethrin, chlorpyrifos and imidacloprid, on the expression of bdnf and c-fos genes in zebrafish brain tissues.	Chlorpyrifos	137-149	brain-derived neurotrophic factor	Danio rerio	189-193
29626809-1	2018	The aim of the present study is to investigate the toxicity effects of frequently used pesticides, involving cypermethrin, deltamethrin, chlorpyrifos and imidacloprid, on the expression of bdnf and c-fos genes in zebrafish brain tissues.	Chlorpyrifos	137-149	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	198-203
29626809-6	2018	These results showed that the exposure to the acute cypermethrin, deltamethrin, chlorpyrifos and imidacloprid intoxication disrupted the normal neuronal activity, resulting in neurotoxic effect, also DNA-binding Increasing c-fos activation, an oncoprotein from the family of the Nuclear Proteins, is also true of the knowledge that these chemicals are oncogenic in zebrafish brain tissues.	Chlorpyrifos	80-92	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	223-228
29736246-0	2018	Effects of magnesium chloride on in vitro cholinesterase and ATPase poisoning by organophosphate (chlorpyrifos).	Chlorpyrifos	98-110	dynein axonemal heavy chain 8	Homo sapiens	61-67
29665406-0	2018	SN56 neuronal cell death after 24 h and 14 days chlorpyrifos exposure through glutamate transmission dysfunction, increase of GSK-3beta enzyme, beta-amyloid and tau protein levels.	Chlorpyrifos	48-60	glycogen synthase kinase 3 beta	Mus musculus	126-135
30127816-1	2018	Chlorpyrifos (CP), an acetylcholinesterase (AChE) inhibitor, is used throughout the world as an insecticide in agriculture and an eradicating agent for termites around homes.	Chlorpyrifos	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-48
29404631-0	2018	New mechanistic insights on the metabolic-disruptor role of chlorpyrifos in apoE mice: a focus on insulin- and leptin-signalling pathways.	Chlorpyrifos	60-72	apolipoprotein E	Mus musculus	76-80
29404631-1	2018	Recently, we have provided evidence, suggesting that mice expressing the human apolipoprotein E3 (apoE3) are more prone to develop an obesity-like phenotype and a diabetic profile when subchronically fed a chlorpyrifos (CPF)-supplemented diet.	Chlorpyrifos	206-218	apolipoprotein E	Homo sapiens	79-96
29404631-1	2018	Recently, we have provided evidence, suggesting that mice expressing the human apolipoprotein E3 (apoE3) are more prone to develop an obesity-like phenotype and a diabetic profile when subchronically fed a chlorpyrifos (CPF)-supplemented diet.	Chlorpyrifos	206-218	apolipoprotein E	Homo sapiens	98-103
29404631-1	2018	Recently, we have provided evidence, suggesting that mice expressing the human apolipoprotein E3 (apoE3) are more prone to develop an obesity-like phenotype and a diabetic profile when subchronically fed a chlorpyrifos (CPF)-supplemented diet.	Chlorpyrifos	220-223	apolipoprotein E	Homo sapiens	79-96
29404631-1	2018	Recently, we have provided evidence, suggesting that mice expressing the human apolipoprotein E3 (apoE3) are more prone to develop an obesity-like phenotype and a diabetic profile when subchronically fed a chlorpyrifos (CPF)-supplemented diet.	Chlorpyrifos	220-223	apolipoprotein E	Homo sapiens	98-103
29277012-9	2018	Furthermore, the inhibition research indicated that chlorpyrifos could inhibit the HENMT1 activity with the IC50 value of 48.32nM.	Chlorpyrifos	52-64	HEN methyltransferase 1	Homo sapiens	83-89
29736246-4	2018	Results showed that Chlorpyrifos significantly (P &lt; .05) reduced the levels of cholinesterase both in plasma and on red blood cells.	Chlorpyrifos	20-32	butyrylcholinesterase	Homo sapiens	82-96
29736246-5	2018	Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P &lt; .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P &lt; .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase.	Chlorpyrifos	94-106	dynein axonemal heavy chain 8	Homo sapiens	23-29
29736246-5	2018	Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P &lt; .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P &lt; .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase.	Chlorpyrifos	94-106	carbonic anhydrase 2	Homo sapiens	34-45
29736246-5	2018	Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P &lt; .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P &lt; .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase.	Chlorpyrifos	94-106	butyrylcholinesterase	Homo sapiens	212-226
29736246-5	2018	Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P &lt; .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P &lt; .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase.	Chlorpyrifos	94-106	dynein axonemal heavy chain 8	Homo sapiens	39-45
29736246-5	2018	Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P &lt; .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P &lt; .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase.	Chlorpyrifos	94-106	carbonic anhydrase 2	Homo sapiens	246-257
29736246-5	2018	Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P &lt; .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P &lt; .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase.	Chlorpyrifos	143-155	butyrylcholinesterase	Homo sapiens	212-226
29736246-5	2018	Red blood cells Na+/K+ ATPase and Ca2+ ATPase were also significantly (P &lt; .05) reduced by chlorpyrifos while MgCl2 counteracted effects of chlorpyrifos with significant (P &lt; .05) increase in the levels of cholinesterase, Na+/K+ ATPase and Ca2+ ATPase.	Chlorpyrifos	143-155	carbonic anhydrase 2	Homo sapiens	246-257
29736246-6	2018	We concluded that MgCl2 neutralized effects of chlorpyrifos by promoting normal ATPase activities and inhibiting release of acetylcholine from cell.	Chlorpyrifos	47-59	dynein axonemal heavy chain 8	Homo sapiens	80-86
29624020-5	2018	At the dose applied in the experiment, chlorpyrifos decreased the activity of AChE significantly, both in blood and in the brain, and increased the activity of ALT and AST in rat serum.	Chlorpyrifos	39-51	acetylcholinesterase	Rattus norvegicus	78-82
29624020-5	2018	At the dose applied in the experiment, chlorpyrifos decreased the activity of AChE significantly, both in blood and in the brain, and increased the activity of ALT and AST in rat serum.	Chlorpyrifos	39-51	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	168-171
29624020-7	2018	A weaker, but longer, inhibition of AChE activity in both blood and the brain was observed in this group compared to the animals exposed only to chlorpyrifos.	Chlorpyrifos	145-157	acetylcholinesterase	Rattus norvegicus	36-40
29624020-8	2018	However, although enrofloxacin, like chlorpyrifos, increases the activity of ALT and AST in serum, their combined administration did not increase the hepatotoxic effect.	Chlorpyrifos	37-49	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	85-88
28982082-4	2018	Chlorpyrifos (&lt;=EC10) could be documented to be a strong CYP1A inhibitor causing characteristic edema-related toxicity.	Chlorpyrifos	0-12	cytochrome P450, family 1, subfamily A	Danio rerio	60-65
28982082-6	2018	Next to a fast CYP1A induction, CYP1A inhibition could also be detected after 3h short-term exposure of zebrafish embryos to chlorpyrifos.	Chlorpyrifos	125-137	cytochrome P450, family 1, subfamily A	Danio rerio	15-20
28982082-6	2018	Next to a fast CYP1A induction, CYP1A inhibition could also be detected after 3h short-term exposure of zebrafish embryos to chlorpyrifos.	Chlorpyrifos	125-137	cytochrome P450, family 1, subfamily A	Danio rerio	32-37
29475860-2	2018	Chlorpyrifos (CP), a commonly used organophosphate insecticide, has poor target specificity and causes acute neurotoxicity in a wide range of species via the suppression of acetylcholinesterase.	Chlorpyrifos	0-12	Acetylcholine esterase	Drosophila melanogaster	173-193
29453720-0	2018	Cytotoxic effect of chlorpyrifos is associated with activation of Nrf-2/HO-1 system and inflammatory response in tongue of male Wistar rats.	Chlorpyrifos	20-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-71
29453720-0	2018	Cytotoxic effect of chlorpyrifos is associated with activation of Nrf-2/HO-1 system and inflammatory response in tongue of male Wistar rats.	Chlorpyrifos	20-32	heme oxygenase 1	Rattus norvegicus	72-76
29624020-1	2018	This study examined the effect of chlorpyrifos and/or enrofloxacin on the activity of acetylcholinesterase (AChE) in the blood and brain, and the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum.	Chlorpyrifos	34-46	acetylcholinesterase	Rattus norvegicus	86-106
29624020-1	2018	This study examined the effect of chlorpyrifos and/or enrofloxacin on the activity of acetylcholinesterase (AChE) in the blood and brain, and the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum.	Chlorpyrifos	34-46	acetylcholinesterase	Rattus norvegicus	108-112