PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 3554204-8 1986 Plasma luteinizing hormone (LH) levels in aflatoxin-fed males were significantly higher than in control or pair-fed males prior to LHRH administration. Aflatoxins 42-51 gonadotropin releasing hormone 1 Homo sapiens 131-135 2498138-0 1989 Variations in the levels of aflatoxin in cows milk consumed in the city of Sao Paulo, Brazil. Aflatoxins 28-37 primary amine oxidase, liver isozyme Bos taurus 75-78 2921209-3 1989 Concentrations of aflatoxin in shelled corn and complete feed were as high as 2,020 ng and 1,200 ng of aflatoxin (B1 and B2)/g of feed, respectively. Aflatoxins 18-27 anthocyanin regulatory R-S protein-like Zea mays 103-123 3195047-5 1988 The BHT treatment increased the activities of the enzymes glutathione-S-transferase, aniline hydroxylase and O-demethylase, which metabolize aflatoxins in the liver. Aflatoxins 141-151 glutathione S-transferase kappa 1 Homo sapiens 58-83 3604040-4 1987 The activities of serum sorbitol dehydrogenase (SDH) and glutamic dehydrogenase (GDH) and concentrations of potassium were significantly elevated, and total protein and calcium levels were decreased in aflatoxin-fed chicks. Aflatoxins 202-211 sorbitol dehydrogenase Homo sapiens 24-46 3604040-4 1987 The activities of serum sorbitol dehydrogenase (SDH) and glutamic dehydrogenase (GDH) and concentrations of potassium were significantly elevated, and total protein and calcium levels were decreased in aflatoxin-fed chicks. Aflatoxins 202-211 sorbitol dehydrogenase Homo sapiens 48-51 2538017-5 1989 HCC has a multifactorial etiology in which the most important factors are the Hepatitis B virus, cirrhosis and aflatoxin with alcohol as synergic co-carcinogen. Aflatoxins 111-120 HCC Homo sapiens 0-3 2738124-2 1989 Because the metabolites aflatoxin M1, aflatoxin P1, aflatoxin Q1, sterigmatocystin, and O-methylsterigmatocystin have the same molecular conversion site, we investigated the chromatographic and spectroscopic properties of hemiacetals of these compounds to assist in confirming aflatoxins and sterigmatocystins in human urine. Aflatoxins 24-33 cholinergic receptor muscarinic 1 Homo sapiens 34-50 2885231-0 1987 The effect of feeding aflatoxin-contaminated groundnut meal, with or without ammoniation, on the development of gamma-glutamyl transferase positive lesions in the livers of Fischer 344 rats. Aflatoxins 22-31 gamma-glutamyltransferase 1 Rattus norvegicus 112-138 2885231-6 1987 The results indicated that ammoniation of the aflatoxin-containing meal eliminated the development of focal GGT positive lesions in both male and female animals. Aflatoxins 46-55 gamma-glutamyltransferase 1 Rattus norvegicus 108-111 2885231-7 1987 However, in the female, histochemical GGT staining of hepatocytes in the periportal areas was increased by all the experimental diets compared with the unammoniated, aflatoxin-free diet. Aflatoxins 166-175 gamma-glutamyltransferase 1 Rattus norvegicus 38-41 3462193-14 1986 The dosage of aflatoxin that can induce chromosomal aberration of human peripheral blood lymphocytes is thousands-fold of the dosage of T-2 toxin as shown in this report. Aflatoxins 14-23 solute carrier family 25 member 5 Homo sapiens 136-139 3094515-3 1986 In the induction of aflatoxin B1 mutagenicity, this hamster cytochrome P-450 is 50 times more potent than those from rat liver. Aflatoxins 20-29 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 60-76 6097059-2 1984 AFB1 metabolism by hepatic microsomes from PBB- and PCB-treated rats resulted in 16- and 30-fold increases, respectively, in levels of aflatoxin M1. Aflatoxins 135-144 pyruvate carboxylase Rattus norvegicus 52-55 6440143-4 1984 In a competitive radioimmunoassay using [3H]aflatoxin B1, 3 pmol (1 ng) of aflatoxin B1, aflatoxin B2, or aflatoxin M1 caused 50% inhibition with this antibody. Aflatoxins 44-53 membrane spanning 4-domains A1 Homo sapiens 85-101 2877443-5 1986 An interaction between aflatoxin and the two nutrients was also observed in liver glutathione content and GGT activity at Week 3. Aflatoxins 23-32 gamma-glutamyltransferase 1 Rattus norvegicus 106-109 3935099-6 1985 Brain and plasma cholinesterase activities in birds fed aflatoxins and given a dose of malathion below the threshold for cholinergic signs (125 mg/kg) were also lower than activities in birds given malathion alone. Aflatoxins 56-66 butyrylcholinesterase Gallus gallus 17-31 3925946-2 1985 Cytochromes P-450 used were cytochrome P-450 I-d and cytochrome P-450 II-a prepared from hepatic microsomes of polychlorinated biphenyl-treated rats; the main metabolic products of aflatoxin B1 were aflatoxin Q1 and aflatoxin M1, respectively. Aflatoxins 181-190 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 53-69 3917582-0 1985 S-9 metabolic activation enhances aflatoxin-mediated transformation of C3H/10T1/2 cells. Aflatoxins 34-43 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Mus musculus 0-3 3938081-2 1985 Four of the naturally occurring aflatoxins (B1, B2, G and G2) were incubated in vitro with whole human serum and subsequently tested for effects on antigenicities and electrophoretic mobilities of the proteins. Aflatoxins 32-42 membrane spanning 4-domains A1 Homo sapiens 44-60 6537939-2 1984 Total tryptophan 2,3-dioxygenase activity was reduced by aflatoxin treatment while holoenzyme activity was not. Aflatoxins 57-66 tryptophan 2,3-dioxygenase Rattus norvegicus 6-32 6537939-4 1984 It is suggested that aflatoxin may alter the tryptophan 2,3-dioxygenase-haem bond in vivo rather than affect enzyme or cofactor synthesis. Aflatoxins 21-30 tryptophan 2,3-dioxygenase Rattus norvegicus 45-71 6225224-5 1983 Signs of chronic toxicosis in rats fed aflatoxin-contaminated corn included increased mortality, decreased hematocrit and hemoglobin levels, elevated serum alkaline phosphatase activities, and a 100% incidence of liver neoplasia. Aflatoxins 39-48 non-symbiotic hemoglobin Zea mays 122-132 6100289-5 1984 Studies in East Africa have shown a correlation between aflatoxin contamination and the incidence of HCC. Aflatoxins 56-65 HCC Homo sapiens 101-104 6811035-4 1982 Aflatoxicol, a metabolite of aflatoxins B1 and B2, was detected in the sera of children with kwashiorkor and marasmic kwashiorkor but not in the controls and only once in a marasmic child. Aflatoxins 29-39 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 40-49 6410945-5 1983 Although aflatoxin B1 and M1 could be detected in blood and urine at several sampling times during the experimental period in groups II and III steers (given the diets containing aflatoxin), there appeared to be no effects on body weight gains and immune phenomena, such as lymphoblastogenesis and antibody production, but there was a waning of the delayed cutaneous hypersensitivity in steers given aflatoxin-contaminated diets. Aflatoxins 9-18 anthocyanin regulatory R-S protein-like Zea mays 19-28 7134118-2 1982 Aflatoxin, even at levels not growth inhibitory, produced a malabsorption syndrome characterized by steatorrhea, hypocarotenoidemia, and decreased concentrations of bile salts and pancreatic lipase, trypsin, amylase, and RNase. Aflatoxins 0-9 pancreatic lipase related protein 1 Gallus gallus 180-197 7096249-2 1982 A standard solution of aflatoxins B1, B2, G1, G2, and M1 was analyzed solution of aflatoxins B1, B2, G1, G2, and M1 was analyzed at flow rates of 2.0 and 6.0 mL/min. Aflatoxins 23-33 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 34-56 30866213-0 1982 Aflatoxin: Toxicity to Dairy Cattle and Occurrence in Milk and Milk Products - A Review. Aflatoxins 0-9 Weaning weight-maternal milk Bos taurus 54-58 30866213-0 1982 Aflatoxin: Toxicity to Dairy Cattle and Occurrence in Milk and Milk Products - A Review. Aflatoxins 0-9 Weaning weight-maternal milk Bos taurus 63-67 7274186-2 1981 Although various animal tissues are used for bioassay of aflatoxins (B1, B2, G1, G2), a rapid bioassay dependent upon a plant part"s response does not exist. Aflatoxins 57-67 anthocyanin regulatory R-S protein-like Zea mays 69-83 6800645-2 1982 The aflatoxin M1 formation was strictly mediated by P-448 purified from the liver microsomes of polychlorobiphenyl- and 3-methylcholanthrene-treated rats, while the aflatoxin Q1 formation, as well as the binding of DNA, were catalyzed by both P-450 and P448. Aflatoxins 4-13 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 52-57 6800645-2 1982 The aflatoxin M1 formation was strictly mediated by P-448 purified from the liver microsomes of polychlorobiphenyl- and 3-methylcholanthrene-treated rats, while the aflatoxin Q1 formation, as well as the binding of DNA, were catalyzed by both P-450 and P448. Aflatoxins 165-174 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 52-57 6797105-2 1981 to adult male rats on 3 occasions at intervals of 48 h. The testicular distribution and localisation of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) was evaluated histochemically in rats killed 24 h after the last dose of aflatoxin, with or without human chorionic gonadotropin (HCG) stimulation. Aflatoxins 226-235 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Rattus norvegicus 141-151 6797236-5 1981 Hepatomas were observed as early as 9 months of age in CCl4 pre-treated animals given 4 mg/kg aflatoxin daily for 10 days. Aflatoxins 94-103 chemokine (C-C motif) ligand 4 Mus musculus 55-59 6797236-6 1981 It is thus suggested that the repeated use of CCl4 as an anthelmintic in animals which are apparently resistant to the lethal and hepatocarcinogenic action of aflatoxin might increase their sensitivity to this mycotoxin. Aflatoxins 159-168 chemokine (C-C motif) ligand 4 Mus musculus 46-50 7430049-3 1980 Aflatoxins B1, B2, G1, and G2 in the purified extract are resolved in ca 10 min by normal phase HPLC on a microparticulate (5 mum) silica gel column with a 50% water-saturated chloroform-cyclohexane-acetonitrile-ethanol solvent, and are measured by ultraviolet fluorescence in a silica gel-packed flowcell. Aflatoxins 0-10 anthocyanin regulatory R-S protein-like Zea mays 11-29 7322967-3 1981 Pancreatic lipase, the primary fat digestive enzyme, was decreased significantly (P less than .05) at all levels of aflatoxin and at 10 microgram/g was only 40% of the control value, Bile, which is required for lipid digestion and absorption, was decreased highly significantly (P less than .01) in concentration by all growth inhibition levels of aflatoxin. Aflatoxins 116-125 pancreatic lipase related protein 1 Gallus gallus 0-17 7322967-3 1981 Pancreatic lipase, the primary fat digestive enzyme, was decreased significantly (P less than .05) at all levels of aflatoxin and at 10 microgram/g was only 40% of the control value, Bile, which is required for lipid digestion and absorption, was decreased highly significantly (P less than .01) in concentration by all growth inhibition levels of aflatoxin. Aflatoxins 348-357 pancreatic lipase related protein 1 Gallus gallus 0-17 7025712-6 1981 Serum ornithine-carbamoyl transferase and sorbitol dehydrogenase activities were elevated during and 1 to 3 weeks after aflatoxin consumption. Aflatoxins 120-129 sorbitol dehydrogenase Bos taurus 42-64 6787032-7 1981 These findings and data on the detergent treatment of nuclei suggest that the nuclear cytochrome P-448 system, induced by 3-methylcholanthrene and localized in the outer membrane, catalyzes the aflatoxin M1 formation, and the cytochrome P-450 system induced by phenobarbital biotransforms aflatoxin B1 into aflatoxin Q1. Aflatoxins 194-203 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 86-102 6787032-7 1981 These findings and data on the detergent treatment of nuclei suggest that the nuclear cytochrome P-448 system, induced by 3-methylcholanthrene and localized in the outer membrane, catalyzes the aflatoxin M1 formation, and the cytochrome P-450 system induced by phenobarbital biotransforms aflatoxin B1 into aflatoxin Q1. Aflatoxins 289-298 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 86-102 6787032-7 1981 These findings and data on the detergent treatment of nuclei suggest that the nuclear cytochrome P-448 system, induced by 3-methylcholanthrene and localized in the outer membrane, catalyzes the aflatoxin M1 formation, and the cytochrome P-450 system induced by phenobarbital biotransforms aflatoxin B1 into aflatoxin Q1. Aflatoxins 289-298 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 226-242 90368-0 1979 Inhibition of aflatoxin-induced serum alpha-fetoprotein in rats fed cauliflower. Aflatoxins 14-23 alpha-fetoprotein Rattus norvegicus 38-55 7361439-2 1980 The individual pig"s response to aflatoxin is affected by many factors, but age is especially important with the younger pig much more susceptible to damage than older pigs. Aflatoxins 33-42 phosphatidylinositol glycan anchor biosynthesis class S Sus scrofa 15-20 479083-5 1979 In 5 of the 6 samples containing aflatoxins B1, B2, G1, and G2, methanol-10% NaCl extracted more aflatoxin than did cloroform-water, as measured both by HPLC and by thin layer chromatography. Aflatoxins 33-42 anthocyanin regulatory R-S protein-like Zea mays 44-62 905118-0 1977 The occurrence of aflatoxin in nuts and nut products imported to Finland for human consumption during the years 1974-1976. Aflatoxins 18-27 NUT midline carcinoma family member 1 Homo sapiens 31-34 350119-4 1977 In vitro reductions in migration inhibition factor (MIF) and depressed stimulation indices (Phytohemagglutinin) of peripheral blood lymphocytes were also demonstrated in aflatoxin recipients but did not reach significant levels. Aflatoxins 170-179 macrophage migration inhibitory factor Cavia porcellus 23-50 192462-7 1977 CsC1 gradients of DNA treated in vitro with activated aflatoxin demonstrated binding of the drug to DNA. Aflatoxins 54-63 transmembrane protein 63C Homo sapiens 0-4 613905-2 1977 In 1973, TPI carried out a world-wide survey to ascertain the data available on aflatoxin contamination of food and feedingstuffs (JONES, 1975). Aflatoxins 80-89 triosephosphate isomerase 1 Homo sapiens 9-12 350119-4 1977 In vitro reductions in migration inhibition factor (MIF) and depressed stimulation indices (Phytohemagglutinin) of peripheral blood lymphocytes were also demonstrated in aflatoxin recipients but did not reach significant levels. Aflatoxins 170-179 macrophage migration inhibitory factor Cavia porcellus 52-55 198857-1 1976 The authors observed the influence of the B1 aflatoxin over rat liver and kidneys glucose-6-phosphatase activity. Aflatoxins 45-54 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 82-103 187331-0 1977 Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo. Aflatoxins 77-87 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus 88-97 173384-8 1975 This modification was about as frequent, intense and widespread in aflatoxin-CCl4 and aflatoxin groups but appeared much earlier, as did the first hepatoma, in the aflatoxin-CCl4 group. Aflatoxins 67-76 C-C motif chemokine ligand 4 Rattus norvegicus 77-81 934259-0 1976 Search for B-1 aflatoxin and similar fluorescent compounds in "misso". Aflatoxins 15-24 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 11-14 934259-1 1976 Following previous studies on the investigation of B-1 Aflatoxin in food samples (4,5) we report in this paper the results obtained using thin layer chromatography (TLC) with three different solvent systems and spectrophotometric analysis in order to differentiate actual B-1 Aflatoxin and Aflatoxin-like substances. Aflatoxins 55-64 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 51-54 983340-3 1976 The developed method makes it possible to determine aflatoxins B1, B2, G1, and G2. Aflatoxins 52-62 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 63-81 1170165-3 1975 Satisfactory separation was achieved for commercial oils spiked with sterigmatocystin, zearalenone, ochratoxins A, B, and C, and aflatoxins B1, B2, G1, and G2. Aflatoxins 129-139 anthocyanin regulatory R-S protein-like Zea mays 140-158 812163-9 1975 Aflatoxin M1 and 3 other metabolites more polar than AFB1 were also produced. Aflatoxins 0-9 myoregulin Homo sapiens 10-18 5016661-0 1972 Toxicity and sterilization effectiveness of aflatoxins B 1 and G 1 and distribution of aflatoxin B 1 - 14 C in house flies. Aflatoxins 44-54 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 55-109 4209123-2 1974 Fluorodenisitometric method for determination of aflatoxins M1 and M2 in presence of aflatoxins B1, B2, G1, and G21. Aflatoxins 49-59 5-hydroxytryptamine receptor 1A Homo sapiens 96-115 4209123-2 1974 Fluorodenisitometric method for determination of aflatoxins M1 and M2 in presence of aflatoxins B1, B2, G1, and G21. Aflatoxins 85-95 5-hydroxytryptamine receptor 1A Homo sapiens 96-115 4631234-0 1972 Effect of aflatoxin on the induction of histidase. Aflatoxins 10-19 histidine ammonia-lyase Homo sapiens 40-49 4992832-0 1971 Aflatoxin P-1: a new aflatoxin metabolite in monkeys. Aflatoxins 21-30 crystallin gamma F, pseudogene Homo sapiens 10-13 4401294-0 1971 The in vitro reduction of aflatoxins B 1 and B 2 by soluble avian liver enzymes. Aflatoxins 26-36 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 37-47 5545312-0 1971 Total syntheses of aflatoxins M1 and G1 and an improved synthesis of aflatoxin B1. Aflatoxins 19-29 myoregulin Homo sapiens 30-39 33997330-7 2021 Furthermore, recent data provide evidence that in the mammary tissue of lactating dairy cows, aflatoxins significantly increase the activity of a protein, ATP-binding cassette super-family G member 2 (ABCG2), an efflux transporter known to facilitate the excretion of various xenobiotics and veterinary drugs into milk. Aflatoxins 94-104 ATP binding cassette subfamily G member 2 Bos taurus 155-199 4318833-0 1969 Carcinogenesis in rats by aflatoxins B1, G1, and B2. Aflatoxins 26-36 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus 37-51 33723771-2 2021 The present study was conducted with the objectives to determine the occurrence of aflatoxins (B1, B2, G1, and G2) in dairy animal concentrate feed and to evaluate the effect of season, spatial variation, and dairy farm size on the levels of aflatoxins contamination. Aflatoxins 83-93 membrane spanning 4-domains A1 Homo sapiens 95-105 33997330-7 2021 Furthermore, recent data provide evidence that in the mammary tissue of lactating dairy cows, aflatoxins significantly increase the activity of a protein, ATP-binding cassette super-family G member 2 (ABCG2), an efflux transporter known to facilitate the excretion of various xenobiotics and veterinary drugs into milk. Aflatoxins 94-104 ATP binding cassette subfamily G member 2 Bos taurus 201-206 32419674-1 2020 The aim of this study was to develop a highly-sensitive liquid chromatographic - tandem mass spectrometric (LC-MS/MS) method to investigate the presence of aflatoxins (AFB1, AFB2, AFG1 and AFG2) and ochratoxin A (OTA) in traditional homemade sausages (n = 88) collected from small family farms situated in different regions in Croatia. Aflatoxins 156-166 spermatogenesis associated 5 Homo sapiens 189-193 33517942-1 2021 OBJECTIVE: We hypothesize that exposure to aflatoxins and fumonisins, measured in serum, alters protein synthesis, reducing serum protein and insulin-like growth factor 1 (IGF-1), increasing inflammation and infection, leading to child linear growth failure. Aflatoxins 43-53 insulin like growth factor 1 Homo sapiens 142-170 33517942-1 2021 OBJECTIVE: We hypothesize that exposure to aflatoxins and fumonisins, measured in serum, alters protein synthesis, reducing serum protein and insulin-like growth factor 1 (IGF-1), increasing inflammation and infection, leading to child linear growth failure. Aflatoxins 43-53 insulin like growth factor 1 Homo sapiens 172-177 33517942-8 2021 In joint statistical tests, aflatoxin exposure was associated with serum biomarkers of inflammation (C-reactive protein, alpha-1-glycoprotein) and protein status (transthyretin, lysine, tryptophan), IGF-1, and linear growth (all p<0.01). Aflatoxins 28-37 C-reactive protein Homo sapiens 101-119 33517942-8 2021 In joint statistical tests, aflatoxin exposure was associated with serum biomarkers of inflammation (C-reactive protein, alpha-1-glycoprotein) and protein status (transthyretin, lysine, tryptophan), IGF-1, and linear growth (all p<0.01). Aflatoxins 28-37 insulin like growth factor 1 Homo sapiens 199-204 32761426-7 2021 CD4+ and CD8+ T cells exhibited lower infiltration levels in tumors with mutations in AXIN1/CTNNB1 and in tumors with aflatoxin-dominant mutational signatures. Aflatoxins 118-127 CD4 molecule Homo sapiens 0-3 32761426-7 2021 CD4+ and CD8+ T cells exhibited lower infiltration levels in tumors with mutations in AXIN1/CTNNB1 and in tumors with aflatoxin-dominant mutational signatures. Aflatoxins 118-127 CD8a molecule Homo sapiens 9-12 33397254-3 2021 CYP1A2 also metabolises certain precarcinogens such as aflatoxins, mycotoxins, nitrosamines, and endogenous substances such as steroids. Aflatoxins 55-65 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 33201356-0 2020 Determination of trace aflatoxin M1 (AFM1) residue in milk by an immunochromatographic assay based on (PEI/PSS)4 red silica nanoparticles. Aflatoxins 23-32 cystatin A Homo sapiens 107-112 33243065-3 2021 This wide-spectrum of biocidal activities mediates via a definite inhibitory system named lactoperoxidase system which acts a potent role in the innate immune response since its activity is not restricted by the antimicrobial effect, but might act a significant role in the hydrolysis of many toxins like aflatoxin. Aflatoxins 305-314 lactoperoxidase Homo sapiens 90-105 33050248-3 2020 In Experiment 1, increasing aflatoxin (0, 250, 500 ppb), increased linearly (P < 0.05) aspartate aminotransferase (AST), alkaline phosphatase (ALKP) and gamma-glutamyl transferase (GGT). Aflatoxins 28-37 AST Sus scrofa 87-113 33074405-8 2020 The limits of detection of four aflatoxins are in the range 0.18 to 1.50 ng mL-1 and the average recoveries range from 75.1 to 102.4%, with relative standard deviations (RSDs) less than 13.6%. Aflatoxins 32-42 2'-5' oligoadenylate synthetase 1B Mus musculus 76-80 33050248-3 2020 In Experiment 1, increasing aflatoxin (0, 250, 500 ppb), increased linearly (P < 0.05) aspartate aminotransferase (AST), alkaline phosphatase (ALKP) and gamma-glutamyl transferase (GGT). Aflatoxins 28-37 AST Sus scrofa 115-118 32887494-1 2020 In the biosynthesis of aflatoxin, verA, ver-1, ordB, and hypA genes of the aflatoxin gene cluster are involved in the pathway from versicolorin A (VA) to demethylsterigmatocystin (DMST). Aflatoxins 75-84 pre-mRNA processing factor 40 homolog A Homo sapiens 57-61 32446815-4 2020 The role of HMGB1 in DNA damage in an aflatoxin-induced lung inflammatory environment was investigated in this study. Aflatoxins 38-47 high mobility group box 1 Homo sapiens 12-17 32887494-6 2020 These results indicate that HAMA pigment is a novel aflatoxin precursor which is involved at a certain step after those of ver-1, ordB, and hypA genes between VA and DMST. Aflatoxins 52-61 pre-mRNA processing factor 40 homolog A Homo sapiens 140-144 32887494-1 2020 In the biosynthesis of aflatoxin, verA, ver-1, ordB, and hypA genes of the aflatoxin gene cluster are involved in the pathway from versicolorin A (VA) to demethylsterigmatocystin (DMST). Aflatoxins 23-32 pre-mRNA processing factor 40 homolog A Homo sapiens 57-61 32517894-6 2020 Aflatoxins were detected in a maximum of 13% (AFB1), 16% (AFB2), 1% (AFG1), 2% (AFG2) and 19% (AFM1) of the urine samples. Aflatoxins 0-10 AFG1 like ATPase Homo sapiens 69-73 32196866-5 2020 Use of the VOCs RL-1-178 (30 g L-1 ) as a biofumigant on stored soybean seeds resulted in completely protection (100 %) against the infection as well as completely inhibition on production of aflatoxin (B1 , B2 , and G2 ) (analyzed by HPLC) by the two aflatoxin-producing fungi. Aflatoxins 192-201 seed linoleate 13S-lipoxygenase-1 Glycine max 17-20 32196866-5 2020 Use of the VOCs RL-1-178 (30 g L-1 ) as a biofumigant on stored soybean seeds resulted in completely protection (100 %) against the infection as well as completely inhibition on production of aflatoxin (B1 , B2 , and G2 ) (analyzed by HPLC) by the two aflatoxin-producing fungi. Aflatoxins 252-261 seed linoleate 13S-lipoxygenase-1 Glycine max 17-20 32825718-1 2020 As a class of mycotoxins with regulatory and public health significance, aflatoxins (e.g., aflatoxin B1, B2, G1 and G2) have attracted unparalleled attention from government, academia and industry due to their chronic and acute toxicity. Aflatoxins 73-83 proline rich protein BstNI subfamily 3 Homo sapiens 91-118 32517894-6 2020 Aflatoxins were detected in a maximum of 13% (AFB1), 16% (AFB2), 1% (AFG1), 2% (AFG2) and 19% (AFM1) of the urine samples. Aflatoxins 0-10 spermatogenesis associated 5 Homo sapiens 80-84 33053575-0 2020 Metabolic Syndrome Instead of Aflatoxin-Related TP53 R249S Mutation as a Hepatocellular Carcinoma Risk Factor. Aflatoxins 30-39 tumor protein p53 Homo sapiens 48-52 32569334-10 2020 Genetic selection of ducks for high AFAR activity could be a means to control aflatoxin sensitivity in this poultry species. Aflatoxins 78-87 aldo-keto reductase family 7 member A3 Rattus norvegicus 36-40 32443392-4 2020 In 2012, the International Agency for Research on Cancer (IARC) classified aflatoxins B1, B2, G1, G2, M1 and M2 as group 1 carcinogenic substances, which are a global human health concern. Aflatoxins 75-85 membrane spanning 4-domains A1 Homo sapiens 86-96 32125088-0 2020 Fast and efficient immunoaffinity column cleanup and liquid chromatography-tandem mass spectrometry method for the quantitative analysis of aflatoxins in baby food and feeds. Aflatoxins 140-150 Fas activated serine/threonine kinase Homo sapiens 0-4 32382660-0 2020 Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017). Aflatoxins 17-26 tumor protein p53 Homo sapiens 12-16 33053575-3 2020 OBJECTIVE: The objective of the study was to explore if HCCs carry the TP53 R249S mutation that has linked them to aflatoxin exposure and describe the associated risk factors. Aflatoxins 115-124 tumor protein p53 Homo sapiens 71-75 31600004-1 2020 Dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) such as sitagliptin has been presented as antidiabetic drugs and has numerous restorative advantages over different diseases; however, its defensive role against aflatoxin b1 (AFB1) liver toxicity has not been previously examined. Aflatoxins 213-222 dipeptidylpeptidase 4 Rattus norvegicus 34-39 32210020-10 2020 We speculated that the decreased expression of HRG and PCK2 after aflatoxin exposure to hepatocyte may be related to aflatoxin induced hepatocyte injury and carcinogenesis. Aflatoxins 66-75 histidine rich glycoprotein Homo sapiens 47-50 32210020-10 2020 We speculated that the decreased expression of HRG and PCK2 after aflatoxin exposure to hepatocyte may be related to aflatoxin induced hepatocyte injury and carcinogenesis. Aflatoxins 66-75 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 55-59 32210020-10 2020 We speculated that the decreased expression of HRG and PCK2 after aflatoxin exposure to hepatocyte may be related to aflatoxin induced hepatocyte injury and carcinogenesis. Aflatoxins 117-126 histidine rich glycoprotein Homo sapiens 47-50 32210020-10 2020 We speculated that the decreased expression of HRG and PCK2 after aflatoxin exposure to hepatocyte may be related to aflatoxin induced hepatocyte injury and carcinogenesis. Aflatoxins 117-126 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 55-59 31864190-2 2020 The prepared supramolecular nanohybrid was further packed into a reusable syringe filter holder and applied as an adsorbent for solid phase extraction of four aflatoxins (B1, B2, G1, G2). Aflatoxins 159-169 anthocyanin regulatory R-S protein-like Zea mays 171-185 32268619-0 2020 Association between Urinary Levels of Aflatoxin and Consumption of Food Linked to Maize or Cow Milk or Dairy Products. Aflatoxins 38-47 Weaning weight-maternal milk Bos taurus 95-99 32220140-0 2020 Molecular docking studies and in vitro degradation of four aflatoxins (AFB1 , AFB2 , AFG1 , and AFG2 ) by a recombinant laccase from Saccharomyces cerevisiae. Aflatoxins 59-69 Afg1p Saccharomyces cerevisiae S288C 85-89 32220140-0 2020 Molecular docking studies and in vitro degradation of four aflatoxins (AFB1 , AFB2 , AFG1 , and AFG2 ) by a recombinant laccase from Saccharomyces cerevisiae. Aflatoxins 59-69 AAA family ATPase AFG2 Saccharomyces cerevisiae S288C 96-100 32220140-3 2020 The computational result of docking simulation indicates that each of the aflatoxins tested can interact with laccase with a binding ability of AFB1 >AFG2 >AFG1 >AFB2 . Aflatoxins 74-84 AAA family ATPase AFG2 Saccharomyces cerevisiae S288C 150-154 32220140-3 2020 The computational result of docking simulation indicates that each of the aflatoxins tested can interact with laccase with a binding ability of AFB1 >AFG2 >AFG1 >AFB2 . Aflatoxins 74-84 Afg1p Saccharomyces cerevisiae S288C 156-160 31793394-5 2020 Aflatoxin B1was found in all positive samples and co-occurred with AFB2, AFG1, and AFG2. Aflatoxins 0-9 AFG1 like ATPase Homo sapiens 73-77 31793394-5 2020 Aflatoxin B1was found in all positive samples and co-occurred with AFB2, AFG1, and AFG2. Aflatoxins 0-9 spermatogenesis associated 5 Homo sapiens 83-87 32117099-11 2020 Identifying beneficial alleles derived from Mp719 and closely linked molecular markers through QTL analysis for implementation of MAS could accelerate breeding efforts to reduce aflatoxin accumulation in maize. Aflatoxins 178-187 malate synthase, glyoxysomal Zea mays 130-133 32657210-6 2020 The piperine at 300 microg mL-1 produced higher radial growth inhibition (89%) and aflatoxin production inhibition (69%). Aflatoxins 83-92 L1 cell adhesion molecule Mus musculus 27-31 31681212-1 2019 The purpose of this review is to present information about the role of activation of aflatoxins and other mycotoxins, of the aryl hydrocarbon receptor (AhR) pathway. Aflatoxins 85-95 aryl hydrocarbon receptor Homo sapiens 125-150 31906282-1 2020 Aflatoxin contamination has been causing great concern worldwide due to the major economic impact on crop production and their toxicological effects to human and animals. Aflatoxins 0-9 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 101-105 31253263-4 2019 The results indicated that detection limits for total aflatoxins and zearalenone in a sample were 0.03 and 0.09 ng mL-1, respectively. Aflatoxins 54-64 L1 cell adhesion molecule Mus musculus 115-119 31683906-3 2019 At a concentration of 5 x 105 colony-forming units (CFU) mL-1, it completely inhibited A. flavus growth and decreased aflatoxin production by 93%. Aflatoxins 118-127 L1 cell adhesion molecule Mus musculus 57-61 31612242-0 2019 Aflatoxin B1 enhances pyroptosis of hepatocytes and activation of Kupffer cells to promote liver inflammatory injury via dephosphorylation of cyclooxygenase-2: an in vitro, ex vivo and in vivo study. Aflatoxins 0-9 prostaglandin-endoperoxide synthase 2 Mus musculus 142-158 31681212-1 2019 The purpose of this review is to present information about the role of activation of aflatoxins and other mycotoxins, of the aryl hydrocarbon receptor (AhR) pathway. Aflatoxins 85-95 aryl hydrocarbon receptor Homo sapiens 152-155 31681212-4 2019 Several aflatoxins are planar molecules that can activate the AhR. Aflatoxins 8-18 aryl hydrocarbon receptor Homo sapiens 62-65 31681212-7 2019 Any examination of the effects of aflatoxins and other toxins that act as activators to AhR must consider the potential of the disruption of several cellular functions in order to extend the perception thus far about the toxic and carcinogenic effects of these toxins. Aflatoxins 34-44 aryl hydrocarbon receptor Homo sapiens 88-91 31681212-8 2019 There have been no Reviews of existing data between the relation of AhR and aflatoxins and this one attempts to give information precisely about this dichotomy. Aflatoxins 76-86 aryl hydrocarbon receptor Homo sapiens 68-71 30185944-0 2019 Aflatoxin exposure in children living in Mirpur, Dhaka: data from MAL-ED companion study. Aflatoxins 0-9 mal, T cell differentiation protein Homo sapiens 66-69 31561495-4 2019 A practical solution to decrease crop aflatoxin content is to use aflatoxin biocontrol products based on non-toxin-producing strains of A. flavus. Aflatoxins 38-47 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 33-37 31072027-4 2019 The aims of the current study were to investigate: (1) the ability of MSMEG_5998, an aflatoxin-degrading F420H2-dependent reductase from Mycobacterium smegmatis, to degrade aflatoxin B1 (AFB1) and reduce AFB1-caused damage in HepG2 cell culture model; and (2) whether a thioredoxin (Trx) linkage of MSMEG_5998 enhanced the enzyme activity. Aflatoxins 85-94 thioredoxin Homo sapiens 270-281 31312606-6 2019 Animal experiment was designed using six rat-groups to evaluate CBG effect to reduce harmful effect of aflatoxins. Aflatoxins 103-113 serpin family A member 6 Rattus norvegicus 64-67 31269336-11 2019 Cleaved caspase 3 expression was severely exacerbated in seminiferous tubules in aflatoxin group but cleaved caspase 3 expression level decreased in Afb1 + res. Aflatoxins 81-90 caspase 3 Rattus norvegicus 8-17 31072027-4 2019 The aims of the current study were to investigate: (1) the ability of MSMEG_5998, an aflatoxin-degrading F420H2-dependent reductase from Mycobacterium smegmatis, to degrade aflatoxin B1 (AFB1) and reduce AFB1-caused damage in HepG2 cell culture model; and (2) whether a thioredoxin (Trx) linkage of MSMEG_5998 enhanced the enzyme activity. Aflatoxins 85-94 thioredoxin Homo sapiens 283-286 29980893-0 2019 Aflatoxin-induced upregulation of protein arginine methyltransferase 5 is mediated by protein kinase C and extracellular signal-regulated kinase. Aflatoxins 0-9 protein arginine methyltransferase 5 Homo sapiens 34-70 30897375-8 2019 Additionally, although the nucleotide excision repair (NER) pathway has been previously shown to repair aflatoxin-induced DNA adducts, recent murine data demonstrated that NEIL1-initiated base excision repair was significantly more important than NER relative to the removal of the highly mutagenic AFB1-Fapy-dG adducts. Aflatoxins 104-113 nei endonuclease VIII-like 1 (E. coli) Mus musculus 172-177 30897375-9 2019 These data suggest that inactivating polymorphic variants of NEIL1 could be a potential driver of HCCs in aflatoxin-exposed populations. Aflatoxins 106-115 nei like DNA glycosylase 1 Homo sapiens 61-66 31001207-0 2019 Set3 Is Required for Asexual Development, Aflatoxin Biosynthesis, and Fungal Virulence in Aspergillus flavus. Aflatoxins 42-51 histone-binding protein SET3 Saccharomyces cerevisiae S288C 0-4 30841652-8 2019 It is proposed for the health protection of infants and young children, a vulnerable group, to establish the lowest maximum level for the sum of aflatoxins (B1, B2, G1 and G2) in baby food. Aflatoxins 145-155 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 157-174 29980893-1 2019 Aflatoxins are fungal metabolites classified into four major groups such as B1, B2, G1, and G2. Aflatoxins 0-10 Bardet-Biedl syndrome 9 Homo sapiens 76-94 30691002-6 2019 HPLC analysis of aflatoxins of the water-soluble fraction of kwete indicated that fermentation led to an over 1000-fold reduction of aflatoxins B1, B2, G1, and G2 spiked in the raw ingredients. Aflatoxins 133-143 anthocyanin regulatory R-S protein-like Zea mays 144-162 30467879-8 2019 Compared with other analytical techniques for aflatoxin screening in agricultural products, this CE-LIF method combined with VALDS-ME preconcentration technique is simple, rapid, highly efficient, and inexpensive. Aflatoxins 46-55 LIF interleukin 6 family cytokine Bos taurus 100-103 30159329-5 2018 Moreover, with the treatment of aflatoxins, proline dehydrogenase (PRODH) and proapoptotic factors (Bax, Caspase-3) were upregulated, while the inhibitor of apoptosis Bcl-2 was downregulated, at both the mRNA and the protein levels, comparing with the control (P < 0.05). Aflatoxins 32-42 proline dehydrogenase Mus musculus 44-65 30361883-7 2018 Under optimal conditions, the detection limits for aflatoxins typically are 0.05-0.07 ng mL-1, recoveries from spiked corn are found to be 75.1 to 99.4%, and relative standard deviations range from 1.7 to 5.1 (n = 6). Aflatoxins 51-61 L1 cell adhesion molecule Mus musculus 89-93 30441861-6 2018 We conjugated aflatoxin, a potent carcinogenic food contaminant, to transferrin and evaluated its potential to stimulate antibody production with respect to ovalbumin conjugates. Aflatoxins 14-23 transferrin Mus musculus 68-79 30441861-7 2018 Transferrin conjugates induced aflatoxin-specific immune responses in the second immunization, while ovalbumin conjugates reached similar antibody titers after 5 injections. Aflatoxins 31-40 transferrin Mus musculus 0-11 30159329-5 2018 Moreover, with the treatment of aflatoxins, proline dehydrogenase (PRODH) and proapoptotic factors (Bax, Caspase-3) were upregulated, while the inhibitor of apoptosis Bcl-2 was downregulated, at both the mRNA and the protein levels, comparing with the control (P < 0.05). Aflatoxins 32-42 proline dehydrogenase Mus musculus 67-72 30159329-5 2018 Moreover, with the treatment of aflatoxins, proline dehydrogenase (PRODH) and proapoptotic factors (Bax, Caspase-3) were upregulated, while the inhibitor of apoptosis Bcl-2 was downregulated, at both the mRNA and the protein levels, comparing with the control (P < 0.05). Aflatoxins 32-42 BCL2-associated X protein Mus musculus 100-103 30159329-5 2018 Moreover, with the treatment of aflatoxins, proline dehydrogenase (PRODH) and proapoptotic factors (Bax, Caspase-3) were upregulated, while the inhibitor of apoptosis Bcl-2 was downregulated, at both the mRNA and the protein levels, comparing with the control (P < 0.05). Aflatoxins 32-42 caspase 3 Mus musculus 105-114 30159329-5 2018 Moreover, with the treatment of aflatoxins, proline dehydrogenase (PRODH) and proapoptotic factors (Bax, Caspase-3) were upregulated, while the inhibitor of apoptosis Bcl-2 was downregulated, at both the mRNA and the protein levels, comparing with the control (P < 0.05). Aflatoxins 32-42 B cell leukemia/lymphoma 2 Mus musculus 167-172 29749584-3 2018 The role of aflatoxin in HCC from a given population is commonly estimated through the prevalence of R249S mutation of TP53, a hallmark for previous exposure to the mycotoxin. Aflatoxins 12-21 tumor protein p53 Homo sapiens 119-123 30231963-5 2018 Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Aflatoxins 0-9 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 44-50 30231963-5 2018 Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Aflatoxins 0-9 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 54-60 30231963-5 2018 Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Aflatoxins 0-9 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 64-71 30231963-5 2018 Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Aflatoxins 0-9 cytochrome P450, family 2, subfamily d, polypeptide 4 Rattus norvegicus 79-85 29604131-7 2018 Expression of glutathione peroxidase 4 gene (GPX4) was significantly reduced due to aflatoxin treatment at 12 and 24 hr, but induced later, while glutathione reductase gene (GSR) expression was significantly lower at 24 hr and glutathione synthetase gene (GSS) in aflatoxin-treated group at 12 hr. Aflatoxins 84-93 glutathione peroxidase 4 Gallus gallus 14-38 29792982-8 2018 Estimated aflatoxins exposure suggested a potential adverse health effect for percentiles of intake above or equal to P50. Aflatoxins 10-20 nuclear factor kappa B subunit 1 Homo sapiens 118-121 29604131-7 2018 Expression of glutathione peroxidase 4 gene (GPX4) was significantly reduced due to aflatoxin treatment at 12 and 24 hr, but induced later, while glutathione reductase gene (GSR) expression was significantly lower at 24 hr and glutathione synthetase gene (GSS) in aflatoxin-treated group at 12 hr. Aflatoxins 84-93 glutathione peroxidase 4 Gallus gallus 45-49 29604131-7 2018 Expression of glutathione peroxidase 4 gene (GPX4) was significantly reduced due to aflatoxin treatment at 12 and 24 hr, but induced later, while glutathione reductase gene (GSR) expression was significantly lower at 24 hr and glutathione synthetase gene (GSS) in aflatoxin-treated group at 12 hr. Aflatoxins 264-273 glutathione peroxidase 4 Gallus gallus 14-38 29604131-7 2018 Expression of glutathione peroxidase 4 gene (GPX4) was significantly reduced due to aflatoxin treatment at 12 and 24 hr, but induced later, while glutathione reductase gene (GSR) expression was significantly lower at 24 hr and glutathione synthetase gene (GSS) in aflatoxin-treated group at 12 hr. Aflatoxins 264-273 glutathione peroxidase 4 Gallus gallus 45-49 29089331-0 2018 Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas. Aflatoxins 14-23 tumor protein p53 Homo sapiens 35-39 29696338-0 2018 Aspergillus flavus GPI-anchored protein-encoding ecm33 has a role in growth, development, aflatoxin biosynthesis, and maize infection. Aflatoxins 90-99 Ecm33p Saccharomyces cerevisiae S288C 49-54 29696338-9 2018 A. flavus Ecm33 is required for proper cell wall composition and plays an important role in normal fungal growth and development, aflatoxin biosynthesis, and seed colonization. Aflatoxins 130-139 Ecm33p Saccharomyces cerevisiae S288C 10-15 29706087-2 2018 The following hypothesized associations were tested in Guatemala: (1) aflatoxin (B1, B2, G1, G2) exposure and environmental enteric dysfunction (EED) and child height-for-age z-score; and (2) aflatoxin exposures and subsequent symptoms of aflatoxins. Aflatoxins 70-79 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 81-95 29329875-0 2018 Hydrolysers of modified mycotoxins in maize: alpha-Amylase and cellulase induce an underestimation of the total aflatoxin content. Aflatoxins 112-121 alpha-amylase Zea mays 45-58 29329875-7 2018 However, alpha-amylase and cellulase incubation caused significant increases in the total free aflatoxin content, 15 +- 8% and 13 +- 5%, respectively. Aflatoxins 95-104 alpha-amylase Zea mays 9-22 29555358-6 2018 When the online analytical method was applied for the determine of trace aflatoxins in real food samples, aflatoxins G1 and aflatoxins B1 could be actually found in one positive bean sauce sample and quantified to be 32.8 and 26.4 mug/kg, respectively. Aflatoxins 73-83 proline rich protein BstNI subfamily 3 Homo sapiens 117-137 29541880-0 2018 RNA interference-based silencing of the alpha-amylase (amy1) gene in Aspergillus flavus decreases fungal growth and aflatoxin production in maize kernels. Aflatoxins 116-125 alpha-amylase Zea mays 40-53 29541880-1 2018 MAIN CONCLUSION: Expressing an RNAi construct in maize kernels that targets the gene for alpha-amylase in Aspergillus flavus resulted in suppression of alpha-amylase (amy1) gene expression and decreased fungal growth during in situ infection resulting in decreased aflatoxin production. Aflatoxins 265-274 alpha-amylase Zea mays 89-102 29541880-1 2018 MAIN CONCLUSION: Expressing an RNAi construct in maize kernels that targets the gene for alpha-amylase in Aspergillus flavus resulted in suppression of alpha-amylase (amy1) gene expression and decreased fungal growth during in situ infection resulting in decreased aflatoxin production. Aflatoxins 265-274 alpha-amylase Zea mays 152-165 29541880-6 2018 Here, we demonstrate that maize inbred B104 expressing an RNAi construct targeting the A. flavus alpha-amylase gene amy1 effectively reduces amy1 gene expression resulting in decreased fungal colonization and aflatoxin accumulation in kernels. Aflatoxins 209-218 alpha-amylase Zea mays 97-110 29513107-3 2018 Aflatoxin-contaminated cereals and oilseeds that contain greater than 20 mug/kg of the toxin (B1, B2, G1, and G2) are adulterated as defined by the Texas Commercial Feed Rules and regulated by the Texas Feed and Fertilizer Control Service of the Office of the Texas State Chemist. Aflatoxins 0-9 anthocyanin regulatory R-S protein-like Zea mays 94-112 28801561-0 2017 Inflammation-mediated SOD-2 upregulation contributes to epithelial-mesenchymal transition and migration of tumor cells in aflatoxin G1-induced lung adenocarcinoma. Aflatoxins 122-131 superoxide dismutase 2 Homo sapiens 22-27 29065686-2 2017 The transformation of a NaBH4-reduced adduct to the aflatoxin system via the Nef-cyclization process was achieved by the assistant of ZnBr2. Aflatoxins 52-61 S100 calcium binding protein B Homo sapiens 77-80 29068381-0 2017 Investigation of Non-Covalent Interactions of Aflatoxins (B1, B2, G1, G2, and M1) with Serum Albumin. Aflatoxins 46-56 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 58-80 28801561-2 2017 Our previous study showed Aflatoxin G1 (AFG1) could induce lung adenocarcinoma in mice. Aflatoxins 26-35 AFG1 like ATPase Homo sapiens 40-44 28428144-5 2017 In 54 patients with gallbladder cancer, tumor tissue was examined for the R249S mutation in TP53, associated with aflatoxin exposure, through targeted sequencing. Aflatoxins 114-123 tumor protein p53 Homo sapiens 92-96 28839428-2 2017 The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Aflatoxins 169-179 HCC Homo sapiens 31-34 28608693-0 2017 Organocatalytic Enantioselective Michael-Acetalization-Reduction-Nef Reaction for a One-Pot Entry to the Functionalized Aflatoxin System. Aflatoxins 120-129 S100 calcium binding protein B Homo sapiens 65-68 28737735-8 2017 Our research indicates that Dot1 is involved in fungal development, aflatoxin biosynthesis and fungal virulence in A. flavus, which might provide a potential target for controlling A. flavus with new strategies. Aflatoxins 68-77 histone methyltransferase DOT1 Saccharomyces cerevisiae S288C 28-32 28608693-2 2017 An efficient method has been developed for the enantioselective synthesis of the aflatoxin system with multiple stereocenters via a sequence of organocatalytic Michael-acetalization-reduction-Nef reactions that proceed with high enantioselectivities (90-99% ee). Aflatoxins 81-90 S100 calcium binding protein B Homo sapiens 192-195 28535182-2 2017 GSTA3 KO mice are sensitive to the acute cytotoxic and genotoxic effects of aflatoxin B1 (AFB1), confirming the crucial role of GSTA3 in resistance to AFB1. Aflatoxins 76-85 glutathione S-transferase, alpha 3 Mus musculus 0-5 28373545-0 2017 NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice. Aflatoxins 23-32 nei endonuclease VIII-like 1 (E. coli) Mus musculus 0-5 28513456-4 2017 Aflatoxins B1, B2, G1, G2, M1 and M2 are the most common derivatives of aflatoxins. Aflatoxins 0-10 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 11-25 28513456-4 2017 Aflatoxins B1, B2, G1, G2, M1 and M2 are the most common derivatives of aflatoxins. Aflatoxins 72-82 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 11-25 28363643-14 2017 Aflatoxin-associated HCC tissues contained high-level potential mutation-associated neoantigens, and many infiltrating lymphocytes and tumors cells that expressed PD-L1, compared to HCCs not associated with aflatoxin. Aflatoxins 0-9 CD274 molecule Homo sapiens 163-168 27187470-0 2016 Monoclonal IgA Antibodies for Aflatoxin Immunoassays. Aflatoxins 30-39 CD79a molecule Homo sapiens 11-14 27924530-5 2017 Aflatoxins B1, B2, G1, G2 are the most toxic and carcinogenic mycotoxins, due to their extreme hepatocarcinogenicity; ochratoxin A is a potent nephrotoxin, it is also carcinogenic, teratogenic, and immunotoxic in rats and possibly in humans; fumonisins are hepatotoxic and nephrotoxic with potential carcinogenic effects on rat and mice. Aflatoxins 0-10 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus 11-25 26968497-8 2016 Further analysis indicated that Pkc proteins were activated and Bcl-2 was reduced in the placental tissue of the aflatoxin-treated groups. Aflatoxins 113-122 B cell leukemia/lymphoma 2 Mus musculus 64-69 27153064-2 2016 High rates of GNMT knockout mice developed HCC, while overexpression of GNMT prevented aflatoxin-induced carcinogenicity and inhibited liver cancer cell proliferation. Aflatoxins 87-96 glycine N-methyltransferase Mus musculus 72-76 26319021-7 2015 The education intervention significantly increased the participants" knowledge on HCC and its risk factors, particularly regarding the use of pesticides at home and aflatoxin contaminated foods (both p < 0.05). Aflatoxins 165-174 HCC Homo sapiens 82-85 26927175-0 2016 Aflatoxin M1 in Cow"s Milk: Method Validation for Milk Sampled in Northern Italy. Aflatoxins 0-9 Weaning weight-maternal milk Bos taurus 22-26 26927175-0 2016 Aflatoxin M1 in Cow"s Milk: Method Validation for Milk Sampled in Northern Italy. Aflatoxins 0-9 Weaning weight-maternal milk Bos taurus 50-54 27097068-0 2016 Monoclonal Antibodies MAM-D3E4, MAM-D3C6, MAM-D12E2, and MAM-D4D6 Against Aflatoxins. Aflatoxins 74-84 sarcoglycan gamma Homo sapiens 22-25 27097068-0 2016 Monoclonal Antibodies MAM-D3E4, MAM-D3C6, MAM-D12E2, and MAM-D4D6 Against Aflatoxins. Aflatoxins 74-84 sarcoglycan gamma Homo sapiens 32-35 27097068-0 2016 Monoclonal Antibodies MAM-D3E4, MAM-D3C6, MAM-D12E2, and MAM-D4D6 Against Aflatoxins. Aflatoxins 74-84 sarcoglycan gamma Homo sapiens 32-35 27097068-0 2016 Monoclonal Antibodies MAM-D3E4, MAM-D3C6, MAM-D12E2, and MAM-D4D6 Against Aflatoxins. Aflatoxins 74-84 sarcoglycan gamma Homo sapiens 32-35 26975102-1 2015 To establish a multi-pretreatment method for the determination of aflatoxin B1, B2, G1, G2 in Chinese patent medicines, aflatoxins were analyzed by high performance liquid chromatography-fluorescence detector with post-column derivatization, after the multi-pretreatment of samples. Aflatoxins 120-130 proline rich protein BstNI subfamily 3 Homo sapiens 66-90 25855716-8 2015 Aflatoxin-associated differential methylation was observed in growth factor genes such as FGF12 and IGF1, and immune-related genes such as CCL28, TLR2 and TGFBI. Aflatoxins 0-9 fibroblast growth factor 12 Homo sapiens 90-95 25855716-8 2015 Aflatoxin-associated differential methylation was observed in growth factor genes such as FGF12 and IGF1, and immune-related genes such as CCL28, TLR2 and TGFBI. Aflatoxins 0-9 insulin like growth factor 1 Homo sapiens 100-104 25855716-8 2015 Aflatoxin-associated differential methylation was observed in growth factor genes such as FGF12 and IGF1, and immune-related genes such as CCL28, TLR2 and TGFBI. Aflatoxins 0-9 C-C motif chemokine ligand 28 Homo sapiens 139-144 25855716-8 2015 Aflatoxin-associated differential methylation was observed in growth factor genes such as FGF12 and IGF1, and immune-related genes such as CCL28, TLR2 and TGFBI. Aflatoxins 0-9 toll like receptor 2 Homo sapiens 146-150 25855716-8 2015 Aflatoxin-associated differential methylation was observed in growth factor genes such as FGF12 and IGF1, and immune-related genes such as CCL28, TLR2 and TGFBI. Aflatoxins 0-9 transforming growth factor beta induced Homo sapiens 155-160 25855716-9 2015 Moreover, one aflatoxin-associated methylation region (corresponding to the miR-4520b locus) was identified. Aflatoxins 14-23 microRNA 4520-2 Homo sapiens 76-85 26143454-9 2015 RESULTS: Aflatoxin caused negative changes in all oxidative stress parameters and some biochemical parameters (glucose, triglyceride, cholesterol, creatinine, AST, ALT, ALP, total protein, albumin). Aflatoxins 9-18 PDZ and LIM domain 3 Rattus norvegicus 169-172 25938735-0 2015 Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Aflatoxins 8-17 gonadotropin releasing hormone receptor Rattus norvegicus 109-123 25886382-6 2015 A mutation of TP53 at codon 249 (R249S), specific for exposure to aflatoxin, was detected in cell-free DNA extracted from plasma. Aflatoxins 66-75 tumor protein p53 Homo sapiens 14-18 26090679-0 2015 Characterization of the Maize Chitinase Genes and Their Effect on Aspergillus flavus and Aflatoxin Accumulation Resistance. Aflatoxins 89-98 chitinase chem 5 Zea mays 30-39 26090679-7 2015 Seven chitinase genes were identified that had alleles associated with increased resistance to aflatoxin accumulation and A. flavus infection in field grown maize. Aflatoxins 95-104 chitinase chem 5 Zea mays 6-15 25886382-14 2015 About 1/3 of carriers have moderate to severe liver fibrosis and 60% have detectable aflatoxin-related TP53 R249S mutation. Aflatoxins 85-94 tumor protein p53 Homo sapiens 103-107 25813030-5 2015 Direct competitive enzyme-linked immunosorbent assay demonstrated that the H2 antibody could competitively bind to free FB1, FB2, and FB3, with an IC50 of 0.11, 0.04, and 0.10 muM, respectively; it had no cross-reactivity to deoxynivalenol, nivalenol and aflatoxin. Aflatoxins 255-264 TCF3 fusion partner Homo sapiens 120-123 24668606-0 2015 Aflatoxin exposure is inversely associated with IGF1 and IGFBP3 levels in vitro and in Kenyan schoolchildren. Aflatoxins 0-9 insulin like growth factor 1 Homo sapiens 48-52 26133228-4 2015 The aflatoxin most frequently detected in the samples was AFG1, present in 57.9% of samples, while the other aflatoxins were rarely present. Aflatoxins 4-13 AFG1 like ATPase Homo sapiens 58-62 24668606-0 2015 Aflatoxin exposure is inversely associated with IGF1 and IGFBP3 levels in vitro and in Kenyan schoolchildren. Aflatoxins 0-9 insulin like growth factor binding protein 3 Homo sapiens 57-63 24668606-6 2015 Path analysis suggested that IGF1 levels explained ~16% of the impact of aflatoxin exposure on child height (p = 0.052). Aflatoxins 73-82 insulin like growth factor 1 Homo sapiens 29-33 24675090-9 2014 The inability to rescue GSTA3 knockout mice from aflatoxin genotoxicity through the Nrf2 transcriptional program indicates that Gsta3 is unilaterally responsible for the detoxication of aflatoxin in mice. Aflatoxins 186-195 glutathione S-transferase, alpha 3 Mus musculus 128-133 25404244-8 2014 Furthermore, the accumulations of carcinogens such as aflatoxin were shown to yield an oncogenic mutated p53 protein. Aflatoxins 54-63 tumor protein p53 Homo sapiens 105-108 25606005-3 2014 Aflatoxins were found in 124 out of the 729 analyzed samples: 65 containing aflatoxin B1 (AFB1), 24 with aflatoxin B2 (AFB2), 15 with aflatoxin G1 (AFG1), and 20 samples with aflatoxin G2 (AFG2). Aflatoxins 0-10 AFG1 like ATPase Homo sapiens 148-152 25606005-3 2014 Aflatoxins were found in 124 out of the 729 analyzed samples: 65 containing aflatoxin B1 (AFB1), 24 with aflatoxin B2 (AFB2), 15 with aflatoxin G1 (AFG1), and 20 samples with aflatoxin G2 (AFG2). Aflatoxins 0-10 spermatogenesis associated 5 Homo sapiens 189-193 25141002-1 2014 The purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced immunosuppression. Aflatoxins 90-99 anthocyanin regulatory R-S protein-like Zea mays 100-119 24398669-5 2014 This transversion is consistent with previous mutational data derived from aflatoxin-associated HCCs. Aflatoxins 75-84 holocytochrome c synthase Homo sapiens 96-100 24675090-1 2014 Mice are resistant to aflatoxin hepatotoxicity, primarily due to high expression of glutathione S-transferases (GSTs), and in particular the GSTA3 subunit. Aflatoxins 22-31 glutathione S-transferase, alpha 3 Mus musculus 112-116 24675090-1 2014 Mice are resistant to aflatoxin hepatotoxicity, primarily due to high expression of glutathione S-transferases (GSTs), and in particular the GSTA3 subunit. Aflatoxins 22-31 glutathione S-transferase, alpha 3 Mus musculus 141-146 24675090-2 2014 Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling, which controls a broad-based cytoprotective response, was activated either genetically or pharmacologically in an attempt to rescue GSTA3 knockout mice from aflatoxin genotoxicity. Aflatoxins 219-228 nuclear factor, erythroid derived 2, like 2 Mus musculus 45-49 24675090-2 2014 Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling, which controls a broad-based cytoprotective response, was activated either genetically or pharmacologically in an attempt to rescue GSTA3 knockout mice from aflatoxin genotoxicity. Aflatoxins 219-228 glutathione S-transferase, alpha 3 Mus musculus 194-199 24657665-3 2014 The G to T transversion at the third position of codon 249 (AGG) of the TP53 gene, substituting arginine to serine, is the most common aflatoxin-induced mutation linked to HCC. Aflatoxins 135-144 tumor protein p53 Homo sapiens 72-76 23649769-0 2013 Hepatocellular carcinoma and liver cirrhosis TP53 mutation analysis reflects a moderate dietary exposure to aflatoxins in Espirito Santo State, Brazil. Aflatoxins 108-118 tumor protein p53 Homo sapiens 45-49 24636559-7 2014 In particular, the inclusion of an IAC step allowed achieving LOQs as low as 0.05 and 0.25mug/kg in cereals for aflatoxins and ochratoxin A, respectively. Aflatoxins 112-122 TARBP2 subunit of RISC loading complex Homo sapiens 62-66 24672518-12 2014 Future validation for all of these miRNAs will be needed to assess their prognostic significance and confirm their relationship with the induction of HCC due to aflatoxin exposure. Aflatoxins 161-170 HCC Homo sapiens 150-153 25011557-2 2014 Traditional dried food was suggested as the major reason for high HCC numbers, due to possible aflatoxin contamination during manufacturing. Aflatoxins 95-104 HCC Homo sapiens 66-69 25029403-1 2014 The occurrence of aflatoxin (aflatoxin B1, aflatoxin B2, aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2)) and heavy metal (Pb, Cd, As and Hg) contamination was determined in 40 industrially produced animal feed samples which were collected from the southwest of Iran. Aflatoxins 18-27 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 39-69 25029403-3 2014 A positive correlation was found between four types of aflatoxins in all the tested samples (p < 0.01) and the positive correlation between AFG1 and AFG2 was significant (r(2) = 0.708). Aflatoxins 55-65 AFG1 like ATPase Homo sapiens 143-147 25396715-7 2014 A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using an electrospray ionisation interface (ESI) in both positive- and negative-ion modes was developed for the simultaneous determination of aflatoxins (AFB1, AFB2, AFG1 and AFG2), ochratoxin A (OTA), zearalenone (ZEA), deoxynivalenol (DON), fumonisins (FB1 and FB2), T-2 and HT-2 toxin in PKC. Aflatoxins 209-219 TCF3 fusion partner Homo sapiens 222-225 23836507-5 2013 We have analyzed the associations between 19 SNPs spanning the TP53 locus and a single specific aflatoxin-induced TP53 mutation (R249S) in 85 in hepatocellular carcinoma cases and 132 controls from Thailand. Aflatoxins 96-105 tumor protein p53 Homo sapiens 63-67 23836507-5 2013 We have analyzed the associations between 19 SNPs spanning the TP53 locus and a single specific aflatoxin-induced TP53 mutation (R249S) in 85 in hepatocellular carcinoma cases and 132 controls from Thailand. Aflatoxins 96-105 tumor protein p53 Homo sapiens 114-118 32261122-4 2013 The results of electrochemical response studies of the BSA/Ab-AFB1/n-Sm2O3/ITO immunoelectrode obtained as a function of aflatoxin concentration reveal a linearity of 10-700 pg mL-1, a detection limit of 57.82 pg mL-1 cm-2, a response time of 5 s and a sensitivity of 48.39 muA pg-1 mL-1 cm-2 with a regression coefficient of 0.961. Aflatoxins 121-130 2'-5' oligoadenylate synthetase 1B Mus musculus 177-181 32261122-4 2013 The results of electrochemical response studies of the BSA/Ab-AFB1/n-Sm2O3/ITO immunoelectrode obtained as a function of aflatoxin concentration reveal a linearity of 10-700 pg mL-1, a detection limit of 57.82 pg mL-1 cm-2, a response time of 5 s and a sensitivity of 48.39 muA pg-1 mL-1 cm-2 with a regression coefficient of 0.961. Aflatoxins 121-130 2'-5' oligoadenylate synthetase 1B Mus musculus 213-222 32261122-4 2013 The results of electrochemical response studies of the BSA/Ab-AFB1/n-Sm2O3/ITO immunoelectrode obtained as a function of aflatoxin concentration reveal a linearity of 10-700 pg mL-1, a detection limit of 57.82 pg mL-1 cm-2, a response time of 5 s and a sensitivity of 48.39 muA pg-1 mL-1 cm-2 with a regression coefficient of 0.961. Aflatoxins 121-130 2'-5' oligoadenylate synthetase 1B Mus musculus 213-217 23649769-1 2013 The close relationship between aflatoxins and 249ser TP53 gene mutation (AGG to AGT, Arg to Ser) in hepatocellular carcinoma (HCC) makes this mutation an indirect indicator of dietary contamination with this toxin. Aflatoxins 31-41 tumor protein p53 Homo sapiens 53-57 23649769-1 2013 The close relationship between aflatoxins and 249ser TP53 gene mutation (AGG to AGT, Arg to Ser) in hepatocellular carcinoma (HCC) makes this mutation an indirect indicator of dietary contamination with this toxin. Aflatoxins 31-41 angiotensinogen Homo sapiens 80-83 23649769-9 2013 TP53 exon 7 mutations, which are related to aflatoxins exposure, were found at 14.6% (249ser), 7.3% (250leu) and 2.4% (250ser) in 41 cases of HCC and 1.4% in 74 liver cirrhosis (without HCC) cases, suggesting a moderate dietary exposure to aflatoxins in the Espirito Santo State, Brazil. Aflatoxins 44-54 tumor protein p53 Homo sapiens 0-4 23649769-9 2013 TP53 exon 7 mutations, which are related to aflatoxins exposure, were found at 14.6% (249ser), 7.3% (250leu) and 2.4% (250ser) in 41 cases of HCC and 1.4% in 74 liver cirrhosis (without HCC) cases, suggesting a moderate dietary exposure to aflatoxins in the Espirito Santo State, Brazil. Aflatoxins 240-250 tumor protein p53 Homo sapiens 0-4 23322662-3 2013 The aim of the present study was to describe the collision-induced dissociation behavior of the four most common aflatoxins: B1, B2, G1 and G2. Aflatoxins 113-123 membrane spanning 4-domains A1 Homo sapiens 125-142 23200676-0 2013 Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand. Aflatoxins 32-41 tumor protein p53 Homo sapiens 56-60 23200676-1 2013 Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Aflatoxins 109-118 tumor protein p53 Homo sapiens 170-174 25755469-7 2013 The activities of ALT and AST were found to be elevated while protein content was found to be decreased in aflatoxin-treated mice as compared to vehicle control. Aflatoxins 107-116 glutamic pyruvic transaminase, soluble Mus musculus 18-21 25755469-7 2013 The activities of ALT and AST were found to be elevated while protein content was found to be decreased in aflatoxin-treated mice as compared to vehicle control. Aflatoxins 107-116 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 26-29 22080034-7 2013 Results showed, although supplement of Nanocid to conventional diet had no effect on performance but addition of Nanocid to diet containing 3 ppm aflatoxin increased significantly the cumulative BWG, cumulative feed consumption and decreased FCR in the last 2 weeks of experimental period. Aflatoxins 146-155 FCR Gallus gallus 242-245 22349737-7 2012 We characterized the kinetic parameters of porcine kidney and human recombinant aminoacylase-1 towards some aromatic and aliphatic-derived mercapturates analogue of mycotoxin-mercapturic acids and 3,4-epoxyprecocene, a bioactive epoxide derivated from aflatoxin. Aflatoxins 252-261 aminoacylase 1 Homo sapiens 80-94 24460352-0 2013 Prevalence of aflatoxin induced p53 mutation at codon 249 (R249s) in hepatocellular carcinoma patients with and without hepatitis B surface antigen (HBsAg). Aflatoxins 14-23 tumor protein p53 Homo sapiens 32-35 24460352-14 2013 CONCLUSIONS: Our study shows moderate prevalence of aflatoxin B1-related p53 mutation (R249S) in HCC with or without HBsAg. Aflatoxins 52-61 tumor protein p53 Homo sapiens 73-76 22349737-10 2012 Ours results indicate for the first time that aminoacylase-1 could play an important role in deacetylating mercapturate metabolites of aflatoxin analogues and this process may be in relation with their cyto- and nephrotoxicity in human. Aflatoxins 135-144 aminoacylase 1 Homo sapiens 46-60 22673813-0 2012 A novel method for high preconcentration of ultra trace amounts of B1, B2, G1 and G2 aflatoxins in edible oils by dispersive liquid-liquid microextraction after immunoaffinity column clean-up. Aflatoxins 85-95 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 67-84 22539618-3 2012 Earlier work defined the mutational spectrum in the gpt gene of gpt delta B6C3F1 mice 3 weeks after exposure to aflatoxin. Aflatoxins 112-121 glutamic pyruvic transaminase, soluble Mus musculus 52-55 22539618-3 2012 Earlier work defined the mutational spectrum in the gpt gene of gpt delta B6C3F1 mice 3 weeks after exposure to aflatoxin. Aflatoxins 112-121 glutamic pyruvic transaminase, soluble Mus musculus 64-67 22673813-1 2012 In the present study, a new approach which uses immunoaffinity column clean-up combined with dispersive liquid-liquid microextraction (DLLME) is proposed for the preconcentration of ultra trace amounts of aflatoxins (B1, B2, G1 and G2). Aflatoxins 205-215 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 217-234 22673813-8 2012 The proposed method was applied for preconcentration and determination of B1, B2, G1 and G2 aflatoxin in edible oils. Aflatoxins 92-101 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 74-91 22252351-7 2012 A quadratic effect was observed on the relationship between the concentration of aflatoxin in diets and the serum concentration of alkaline phosphatase, gamma-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase. Aflatoxins 81-90 glutamic--pyruvic transaminase Homo sapiens 181-205 22325339-7 2012 The results demonstrated that supplementation of SPN and/or WPC reduced the oxidative stress induced by AFs as indicated by decreased lipid peroxidation level, increased glutathione content and up-regulated PHGPx gene expression. Aflatoxins 104-107 glutathione peroxidase 4 Rattus norvegicus 207-212 22675488-0 2012 Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. Aflatoxins 0-9 tumor protein p53 Homo sapiens 18-22 22971039-1 2012 A simple method for the reduction of aflatoxins B1 (AFB1), B2 (AFB2), G1 (AFG1), G2 (AFG2) and ochratoxin A (OTA) in white pepper was studied. Aflatoxins 37-47 AFG1 like ATPase Homo sapiens 74-78 22971039-1 2012 A simple method for the reduction of aflatoxins B1 (AFB1), B2 (AFB2), G1 (AFG1), G2 (AFG2) and ochratoxin A (OTA) in white pepper was studied. Aflatoxins 37-47 spermatogenesis associated 5 Homo sapiens 85-89 22675488-3 2012 Most HCC are associated with chronic infection by Hepatitis B Virus while a G T mutation at codon 249 of the TP53 gene, R249S, specific for exposure to aflatoxin, is detected in tumors for up to 30% of cases. Aflatoxins 154-163 tumor protein p53 Homo sapiens 111-115 21755496-6 2011 Treatment of Huh7-1A2-I-E cells and the Huh7-E control cells with aflatoxin B1 showed that cells with CYP1A2 expression are much more sensitive to aflatoxin B1 and the cellular toxicity of aflatoxin B1 in Huh7-1A2-I-E cells could be prevented by furafylline, a CYP1A2 inhibitor. Aflatoxins 66-75 MIR7-3 host gene Homo sapiens 13-17 21755496-6 2011 Treatment of Huh7-1A2-I-E cells and the Huh7-E control cells with aflatoxin B1 showed that cells with CYP1A2 expression are much more sensitive to aflatoxin B1 and the cellular toxicity of aflatoxin B1 in Huh7-1A2-I-E cells could be prevented by furafylline, a CYP1A2 inhibitor. Aflatoxins 66-75 MIR7-3 host gene Homo sapiens 40-44 21755496-6 2011 Treatment of Huh7-1A2-I-E cells and the Huh7-E control cells with aflatoxin B1 showed that cells with CYP1A2 expression are much more sensitive to aflatoxin B1 and the cellular toxicity of aflatoxin B1 in Huh7-1A2-I-E cells could be prevented by furafylline, a CYP1A2 inhibitor. Aflatoxins 66-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 102-108 21755496-6 2011 Treatment of Huh7-1A2-I-E cells and the Huh7-E control cells with aflatoxin B1 showed that cells with CYP1A2 expression are much more sensitive to aflatoxin B1 and the cellular toxicity of aflatoxin B1 in Huh7-1A2-I-E cells could be prevented by furafylline, a CYP1A2 inhibitor. Aflatoxins 66-75 MIR7-3 host gene Homo sapiens 40-44 21755496-6 2011 Treatment of Huh7-1A2-I-E cells and the Huh7-E control cells with aflatoxin B1 showed that cells with CYP1A2 expression are much more sensitive to aflatoxin B1 and the cellular toxicity of aflatoxin B1 in Huh7-1A2-I-E cells could be prevented by furafylline, a CYP1A2 inhibitor. Aflatoxins 66-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 261-267 22347598-2 2011 The aim of this study was to detect aflatoxin B1, B2, G1, G2 and total aflatoxin in Kashkineh, a traditional Iranian food. Aflatoxins 36-45 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 46-60 21957681-9 2011 Aflatoxin metabolites, apart from AFM1 and AFB1 present in the weaning foods, were AFG1 and AFG2. Aflatoxins 0-9 AFG1 like ATPase Homo sapiens 83-87 21641981-0 2011 Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Aflatoxins 0-10 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 22-28 21641981-0 2011 Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Aflatoxins 0-10 nuclear receptor subfamily 1 group I member 2 Homo sapiens 76-79 21957681-9 2011 Aflatoxin metabolites, apart from AFM1 and AFB1 present in the weaning foods, were AFG1 and AFG2. Aflatoxins 0-9 spermatogenesis associated 5 Homo sapiens 92-96 21760996-4 2011 TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development. Aflatoxins 129-138 tumor protein p53 Homo sapiens 0-4 21536149-6 2011 The results indicated that ingestion of aflatoxin resulted in a significant increase in micronucleated normochromatic erythrocytes (Mn-NCE) in bone marrow, DNA fragmentation, FAS mRNA expression and lipid peroxidation in both organs, and a significant decrease in micronucleated polychromatic erythrocytes/micronucleated normochromatic erythrocytes (PCE/NCE) ratio in bone marrow, PHGPx gene expression and GSH in liver and testis. Aflatoxins 40-49 glutathione peroxidase 4 Rattus norvegicus 381-386 21382167-0 2011 Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. Aflatoxins 0-9 tumor protein p53 Homo sapiens 84-87 21382167-2 2011 Aflatoxins, which may play a causative role in 5-28% of HCCs worldwide, are activated in liver cells and induce principally G T mutations, including the TP53 codon 249(G T) hotspot mutation. Aflatoxins 0-10 tumor protein p53 Homo sapiens 153-157 21760996-4 2011 TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development. Aflatoxins 129-138 tumor protein p53 Homo sapiens 67-71 20017137-2 2010 Convincing epidemiological and experimental evidence also links HCC to aflatoxin, a naturally occurring mycotoxin that produces a signature p53-249(ser) mutation. Aflatoxins 71-80 tumor protein p53 Homo sapiens 140-143 21141478-5 2010 The cross-reactivity of the monoclonal antibody clone against aflatoxin M1, aflatoxin M2, aflatoxin B1, aflatoxin B2, aflatoxin G1, aflatoxin G2, deoxynivalenol and BSA was 100%, 4.5%, 21.5%, 1.0%, 16.6%, 1.0%, 0%, 0%, respectively. Aflatoxins 62-71 UDP glucuronosyltransferase 2 family, polypeptide B5 Mus musculus 72-144 20739261-4 2010 Additional increase in HCC incidence is expected as a consequence of climate change, since risk of aflatoxin contamination in agricultural products increases with hot and dry growing conditions. Aflatoxins 99-108 HCC Homo sapiens 23-26 20088648-4 2010 MATERIALS AND METHODS: Animals fed an aflatoxin-contaminated diet (2.5 mg/kg diet) showed a significant decrease in all hematological parameters, cholesterol, triglycerides, cholinesterase, total protein, albumin, zinc and copper concentrations. Aflatoxins 38-47 butyrylcholinesterase Rattus norvegicus 174-188 20348292-0 2010 HypC, the anthrone oxidase involved in aflatoxin biosynthesis. Aflatoxins 39-48 pre-mRNA processing factor 40 homolog B Homo sapiens 0-4 20306157-7 2010 In conclusion, although codon 249 mutation of p53 gene has been found very rare but it exists showing the effect of aflatoxins in HCC patients in Turkey. Aflatoxins 116-126 tumor protein p53 Homo sapiens 46-49 20707407-0 2010 Cloning, expression and functional characterization of cytochrome P450 3A37 from turkey liver with high aflatoxin B1 epoxidation activity. Aflatoxins 104-113 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 66-70 20570793-7 2010 Since geographical distribution of aflatoxin as well as HBV overlaps with each other, they have a synergistic effect on inducing HCC. Aflatoxins 35-44 HCC Homo sapiens 129-132 20381597-0 2010 Aflatoxin G1 reduces the molecular expression of HLA-I, TAP-1 and LMP-2 of adult esophageal epithelial cells in vitro. Aflatoxins 0-9 transporter 1, ATP binding cassette subfamily B member Homo sapiens 56-61 20381597-0 2010 Aflatoxin G1 reduces the molecular expression of HLA-I, TAP-1 and LMP-2 of adult esophageal epithelial cells in vitro. Aflatoxins 0-9 proteasome 20S subunit beta 9 Homo sapiens 66-71 19345001-3 2009 Aflatoxin B1, the most commonly occurring and potent of the aflatoxins is associated with a specific AGG to AGT transversion mutation at codon 249 of the p53 gene in human HCC, providing mechanistic support to a causal link between exposure and disease. Aflatoxins 60-70 angiotensinogen Homo sapiens 108-111 20363399-1 2010 An ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 in traditional Chinese medicines (TCMs) was developed. Aflatoxins 128-138 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 139-153 20127914-1 2010 A rapid and simple method was developed to determine aflatoxins B1, B2, G1, G2 and ochratoxin A in animal feed and pet foods by UHPLC-MS/MS. Aflatoxins 53-63 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 64-78 24779628-1 2010 Aflatoxins (AFB1, AFB2, AFG1 and AFG2) are immunosuppressant, mutagenic, teratogenic and carcinogenic agents with a widespread presence in foodstuffs. Aflatoxins 0-10 AFG1 like ATPase Homo sapiens 24-28 24779628-1 2010 Aflatoxins (AFB1, AFB2, AFG1 and AFG2) are immunosuppressant, mutagenic, teratogenic and carcinogenic agents with a widespread presence in foodstuffs. Aflatoxins 0-10 spermatogenesis associated 5 Homo sapiens 33-37 19345001-3 2009 Aflatoxin B1, the most commonly occurring and potent of the aflatoxins is associated with a specific AGG to AGT transversion mutation at codon 249 of the p53 gene in human HCC, providing mechanistic support to a causal link between exposure and disease. Aflatoxins 60-70 tumor protein p53 Homo sapiens 154-157 19376640-0 2009 The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy. Aflatoxins 4-13 tumor protein p53 Homo sapiens 22-26 19558663-1 2009 BACKGROUND: Ser-249 TP53 mutation (249(Ser)) is a molecular evidence for aflatoxin-related carcinogenesis in Hepatocellular Carcinoma (HCC) and it is frequent in some African and Asian regions, but it is unusual in Western countries. Aflatoxins 73-82 tumor protein p53 Homo sapiens 20-24 19693687-3 2009 Consumption of aflatoxin contaminated foods is a recognised risk factor for human hepatocellular carcinoma (HCC) and may contribute to the high incidence of HCC in Southeast Asia. Aflatoxins 15-24 HCC Homo sapiens 82-112 19693687-3 2009 Consumption of aflatoxin contaminated foods is a recognised risk factor for human hepatocellular carcinoma (HCC) and may contribute to the high incidence of HCC in Southeast Asia. Aflatoxins 15-24 HCC Homo sapiens 108-111 21217847-4 2009 Nerve agents, pesticides, anticholinergic drugs useable for treatment of Alzheimer"s disease as well as myasthenia gravis and aflatoxins are enlisted as compounds simply analyzable by cholinesterase biosensors. Aflatoxins 126-136 butyrylcholinesterase Homo sapiens 184-198 19646059-1 2009 The effect of feta cheese manufacture on aflatoxin M(1) (AFM(1)) content was studied using an enzyme immunoassay technique. Aflatoxins 41-50 ATPase phospholipid transporting 8B5, pseudogene Homo sapiens 14-18 19366907-2 2009 A single base substitution at the third nucleotide of codon 249 of TP53 (R249S) is common in HCC in these regions and has been associated with aflatoxin-DNA adducts. Aflatoxins 143-152 tumor protein p53 Homo sapiens 67-71 19010433-1 2009 Aflatoxins are notorious toxic secondary metabolites known for their impacts on human and animal health, and their effects on the marketability of key grain and nut crops. Aflatoxins 0-10 NUT midline carcinoma family member 1 Homo sapiens 161-164 18834591-4 2008 The mean recoveries of aflatoxins from non-infected peanut and corn samples spiked with aflatoxins B1, B2, G1 and G2 at concentrations from 0.22 to 5 microg/kg were between 83.4% and 94.7%. Aflatoxins 23-33 anthocyanin regulatory R-S protein-like Zea mays 99-116 19132874-5 2009 All strains of A. flavus and A. nidulans produced more conidia and aflatoxin (or the precursor sterigmatocystin) on lox3-4 kernels than on wild-type kernels, in vitro and under field conditions. Aflatoxins 67-76 linoleate 9S-lipoxygenase4 Zea mays 116-122 19077459-6 2009 Aflatoxin B(1) aldehyde reductase (AKR7A2) was confirmed to be only highly expressed in pancreatic cancer, not in normal adjacent pancreas and benign tumors. Aflatoxins 0-9 aldo-keto reductase family 7 member A2 Homo sapiens 35-41 19051581-0 2008 Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice. Aflatoxins 21-30 aminoadipate-semialdehyde synthase Mus musculus 50-53 19051581-1 2008 The present investigation was an attempt to evaluate the ameliorative effect of curcumin on aflatoxin-induced changes in activities of succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase) in liver and kidney of mice. Aflatoxins 92-101 aminoadipate-semialdehyde synthase Mus musculus 135-158 19051581-1 2008 The present investigation was an attempt to evaluate the ameliorative effect of curcumin on aflatoxin-induced changes in activities of succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase) in liver and kidney of mice. Aflatoxins 92-101 aminoadipate-semialdehyde synthase Mus musculus 160-163 19051581-7 2008 The results showed that in liver and kidney of mice activities of both the enzymes succinate dehydrogenase and adenosine triphosphatase were found to be reduced in the groups treated with low dose and high dose of aflatoxin, which were ameliorated by the treatment of curcumin along with aflatoxin in other groups. Aflatoxins 214-223 aminoadipate-semialdehyde synthase Mus musculus 83-106 19051581-7 2008 The results showed that in liver and kidney of mice activities of both the enzymes succinate dehydrogenase and adenosine triphosphatase were found to be reduced in the groups treated with low dose and high dose of aflatoxin, which were ameliorated by the treatment of curcumin along with aflatoxin in other groups. Aflatoxins 288-297 aminoadipate-semialdehyde synthase Mus musculus 83-106 19051581-8 2008 Thus, curcumin along with aflatoxin ameliorates aflatoxin-induced changes in succinate dehydrogenase and adenosine triphosphatase activities in liver and kidney of mice. Aflatoxins 26-35 aminoadipate-semialdehyde synthase Mus musculus 77-100 19051581-8 2008 Thus, curcumin along with aflatoxin ameliorates aflatoxin-induced changes in succinate dehydrogenase and adenosine triphosphatase activities in liver and kidney of mice. Aflatoxins 48-57 aminoadipate-semialdehyde synthase Mus musculus 77-100 17723167-15 2007 Furthermore, clinical interventions have shown that inducers of Keap1-Nrf2- ARE signaling increase cytoprotective enzyme expression, resulting in modulation of aflatoxin disposition. Aflatoxins 160-169 kelch like ECH associated protein 1 Homo sapiens 64-69 17723167-15 2007 Furthermore, clinical interventions have shown that inducers of Keap1-Nrf2- ARE signaling increase cytoprotective enzyme expression, resulting in modulation of aflatoxin disposition. Aflatoxins 160-169 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 17113242-0 2006 Novel adenine adducts, N7-guanine-AFB1 adducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposure. Aflatoxins 103-112 tumor protein p53 Homo sapiens 52-55 16978023-1 2006 We report validation of the first isotope dilution mass spectrometry method for determination of aflatoxin B(1)-N(7)-guanine (AFB(1)-N(7)-Gua), a major human aflatoxin-DNA adduct that is excreted in the urine. Aflatoxins 97-106 DExD-box helicase 21 Homo sapiens 138-141 23605582-9 2006 This linkage has been extended at the molecular level by the characterization of a G-protein/cAMP/Protein kinase A signaling pathway that regulates sporulation via the transcription factor BrlA and aflatoxin/sterigmatocystin production via AflR. Aflatoxins 198-207 cathelicidin antimicrobial peptide Homo sapiens 93-97 16533410-12 2006 Oral administration of aflatoxins (mixture of B1, B2, G1 and G2) and Ochratoxin A. Aflatoxins 23-33 B.burgdorferi-associated arthritis 2 Mus musculus 46-63 16489057-0 2006 Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Aflatoxins 26-35 NFE2 like bZIP transcription factor 2 Rattus norvegicus 79-83 16000399-7 2006 Moreover, Bcrp1 mediates transfer of [14C]IQ, [14C]Trp-P-1 and [3H]aflatoxin into milk, with 3.4+/-0.6, 2.6+/-0.3 and 3.8+/-0.5-fold higher milk to plasma ratios, respectively, in lactating wild-type versus Bcrp1-/- mice. Aflatoxins 67-76 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 10-15 16000399-8 2006 We have thus identified Bcrp1/BCRP as one of the molecular mechanisms by which heterocyclic amines and aflatoxin are transferred into milk, thereby posing a health risk to breast-fed infants and dairy consumers. Aflatoxins 103-112 BCR pseudogene 1 Homo sapiens 24-29 16000399-8 2006 We have thus identified Bcrp1/BCRP as one of the molecular mechanisms by which heterocyclic amines and aflatoxin are transferred into milk, thereby posing a health risk to breast-fed infants and dairy consumers. Aflatoxins 103-112 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 30-34 18357783-4 2007 Allylamine, diethylaminoethylmethacrylate, and N,N"-methylenebisacrylamide, providing high binding energies with aflatoxins B1, B2, and G2 were selected as functional monomers for the formation of aflatoxin B1-imprinted polymer membranes. Aflatoxins 113-123 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 124-138 19069952-1 2007 The present research were tempted to investigate whether Aflatoxin is an additive factor in development of HCC through detecting its metabolite Aflatoxin Ml1 in serum and urine of HCC and cirrhotics in Egypt. Aflatoxins 57-66 interleukin 17F Homo sapiens 154-157 19069952-1 2007 The present research were tempted to investigate whether Aflatoxin is an additive factor in development of HCC through detecting its metabolite Aflatoxin Ml1 in serum and urine of HCC and cirrhotics in Egypt. Aflatoxins 144-153 interleukin 17F Homo sapiens 154-157 17851418-4 2007 Novel aflatoxin bovine serum albumin conjugates were prepared and characterised by UV absorption and MALDI-MS. Aflatoxins 6-15 albumin Homo sapiens 23-36 17203869-2 2006 The levels of non-enzymatic antioxidant such as glutathione as well as the enzymatic antioxidants such as superoxide dismutase, glutathione peroxidase and catalase were significantly lower in the kidney of aflatoxin-treated mice than in the controls. Aflatoxins 206-215 catalase Mus musculus 155-163 15454734-0 2004 Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. Aflatoxins 20-29 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 66-72 23605339-1 2005 Aflatoxin M1, a mutagenic and carcinogenic metabolite of aflatoxin B1, occurs in milk from animals fed on food contaminated with some species ofAspergillus. Aflatoxins 0-9 cholinergic receptor muscarinic 1 Homo sapiens 10-69 16103461-0 2005 Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure. Aflatoxins 72-81 tumor protein p53 Homo sapiens 11-15 16103461-3 2005 A mutation in the TP53 tumor suppressor gene at codon 249 (TP53 Ser249 mutation) has been reported previously for hepatocellular carcinoma tumors and matched plasma DNA samples in individuals from areas with high aflatoxin exposure. Aflatoxins 213-222 tumor protein p53 Homo sapiens 18-22 16103461-3 2005 A mutation in the TP53 tumor suppressor gene at codon 249 (TP53 Ser249 mutation) has been reported previously for hepatocellular carcinoma tumors and matched plasma DNA samples in individuals from areas with high aflatoxin exposure. Aflatoxins 213-222 tumor protein p53 Homo sapiens 59-63 15755146-3 2005 In the biosynthesis of the fungal carcinogen, aflatoxin, six cytochromes P450 are encoded by the biosynthetic gene cluster. Aflatoxins 46-55 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 73-77 15734960-8 2005 Among participants who had all three suspected aflatoxin-related high-risk genotypes [GSTM1 null, HLY1*2 (HY/HH), and XRCC1 (AG/GG)], a significant 15-fold increased risk of HCC was observed albeit with imprecise estimates (OR, 14.7; 95% CI, 1.27-169). Aflatoxins 47-56 glutathione S-transferase mu 1 Homo sapiens 86-91 15734960-8 2005 Among participants who had all three suspected aflatoxin-related high-risk genotypes [GSTM1 null, HLY1*2 (HY/HH), and XRCC1 (AG/GG)], a significant 15-fold increased risk of HCC was observed albeit with imprecise estimates (OR, 14.7; 95% CI, 1.27-169). Aflatoxins 47-56 X-ray repair cross complementing 1 Homo sapiens 118-123 15215318-0 2004 Transcriptional response of yeast to aflatoxin B1: recombinational repair involving RAD51 and RAD1. Aflatoxins 37-46 recombinase RAD51 Saccharomyces cerevisiae S288C 84-89 15215318-0 2004 Transcriptional response of yeast to aflatoxin B1: recombinational repair involving RAD51 and RAD1. Aflatoxins 37-46 ssDNA endodeoxyribonuclease RAD1 Saccharomyces cerevisiae S288C 94-98 12722660-0 2003 [Products of spontaneous conjugation of aflatoxins with bovine serum albumin: immunochemical properties]. Aflatoxins 40-50 albumin Homo sapiens 63-76 18943070-10 2004 These data suggest that GLX-I may play an important role in controlling MG levels inside kernels, thereby contributing to the lower levels of aflatoxins found in resistant maize genotypes. Aflatoxins 142-152 glyoxylase 1 Zea mays 24-29 15095302-2 2004 A selective mutation in TP53 (AGG-->AGT at codon 249, Arg-->Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites. Aflatoxins 161-170 tumor protein p53 Homo sapiens 24-28 15095302-2 2004 A selective mutation in TP53 (AGG-->AGT at codon 249, Arg-->Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites. Aflatoxins 161-170 angiotensinogen Homo sapiens 39-42 14643022-1 2003 Cytochrome P450 3A4 (CYP3A4), a member of multigene superfamily of enzymes, plays a major role in the activation of procarcinogens such as polycyclic hydrocarbon dihydrodiols, aflatoxins and heterocyclic amines as well as of several drugs including tamoxifen which is used in breast cancer therapy. Aflatoxins 176-186 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-19 14643022-1 2003 Cytochrome P450 3A4 (CYP3A4), a member of multigene superfamily of enzymes, plays a major role in the activation of procarcinogens such as polycyclic hydrocarbon dihydrodiols, aflatoxins and heterocyclic amines as well as of several drugs including tamoxifen which is used in breast cancer therapy. Aflatoxins 176-186 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 21-27 14555609-10 2003 Transcript levels of eight genes, including two known to detoxify aflatoxin, namely, glutathione S-transferase A5 (GSTA5) and AFB1 aldehyde reductase (AFAR) were elevated. Aflatoxins 66-75 glutathione S-transferase alpha 5 Homo sapiens 85-113 14555609-10 2003 Transcript levels of eight genes, including two known to detoxify aflatoxin, namely, glutathione S-transferase A5 (GSTA5) and AFB1 aldehyde reductase (AFAR) were elevated. Aflatoxins 66-75 glutathione S-transferase alpha 5 Homo sapiens 115-120 14555609-10 2003 Transcript levels of eight genes, including two known to detoxify aflatoxin, namely, glutathione S-transferase A5 (GSTA5) and AFB1 aldehyde reductase (AFAR) were elevated. Aflatoxins 66-75 aldo-keto reductase family 7 member A2 Homo sapiens 126-149 14555609-10 2003 Transcript levels of eight genes, including two known to detoxify aflatoxin, namely, glutathione S-transferase A5 (GSTA5) and AFB1 aldehyde reductase (AFAR) were elevated. Aflatoxins 66-75 aldo-keto reductase family 7 member A2 Homo sapiens 151-155 12714181-1 2003 G-->T transversions in the TP53 gene are more common in lung cancers from smokers than in any other cancer except for hepatocellular carcinomas linked to aflatoxin. Aflatoxins 157-166 tumor protein p53 Homo sapiens 30-34 12679912-1 2003 AIM: One of the characteristics of hepatocellular carcinoma (HCC) in Qidong area is the selective mutation resulting in a serine substitution at codon 249 of the p53 gene (1, 20), and it has been identified as a "hotspot" mutation in heptocellular carcinomas occurring in populations exposed to aflatoxin and with high prevalence of hepatitis B virus carriers (2,3,9, 10,16,24). Aflatoxins 295-304 tumor protein p53 Homo sapiens 162-165 12503075-1 2003 Livers from wild-type and p53-deficient mice were analyzed for the expression of cell-cycle regulatory proteins in an attempt to determine the mechanism for the increased proliferation of liver cells in p53-deficient mice associated with enhanced susceptibility to aflatoxin-induced liver cancer. Aflatoxins 265-274 transformation related protein 53, pseudogene Mus musculus 203-206 12495021-4 2002 Autoclaved whole seeds, with or without LOX, produced good fungal growth and aflatoxin levels approaching those of broken seeds. Aflatoxins 77-86 linoleate 9S-lipoxygenase-4 Glycine max 40-43 12031498-2 2002 Based on reporter assays and sequence comparisons of the nor1-pksA intergenic region in different aflatoxin-producing Aspergillus species, cis-acting elements for the aflatoxin pathway-specific regulatory protein, AflR, and the global-acting regulatory proteins BrlA and PacC are involved in pksA promoter activity. Aflatoxins 98-107 nuclear receptor subfamily 4 group A member 3 Homo sapiens 57-61 12395332-7 2002 A similar relative risk was found using 249ser-p53 mutation as a marker for aflatoxin exposure. Aflatoxins 76-85 tumor protein p53 Homo sapiens 47-50 12534775-6 2002 However, measures to reduce the high levels of aflatoxin exposure, where chronic HBV infection is currently epidemic, would also significantly contribute to reducing HCC incidence. Aflatoxins 47-56 HCC Homo sapiens 166-169 12435844-3 2002 The improvements in exposure assessment and their application in prospective epidemiological studies and the demonstration of a specific mutation in the TP53 gene in hepatocellular carcinomas from areas of high aflatoxin exposure have contributed significantly to the classification of aflatoxins as human carcinogens. Aflatoxins 211-220 tumor protein p53 Homo sapiens 153-157 12435844-3 2002 The improvements in exposure assessment and their application in prospective epidemiological studies and the demonstration of a specific mutation in the TP53 gene in hepatocellular carcinomas from areas of high aflatoxin exposure have contributed significantly to the classification of aflatoxins as human carcinogens. Aflatoxins 286-296 tumor protein p53 Homo sapiens 153-157 11926047-3 2002 Aflatoxins were detected in 110 (54.7%) samples, 27 of which were positive for B1, 106 for M1 and 31 for M2. Aflatoxins 0-10 myoregulin Homo sapiens 91-100 12131971-6 2002 Peanuts and its products showed the highest levels of aflatoxin contamination (34.7%) with up to 1280 mg/kg of AFB1+AFG1 and 1706 mg/kg of total aflatoxins. Aflatoxins 54-63 AFG1 like ATPase Homo sapiens 116-120 11829670-6 2002 The relative cross-reactivity with aflatoxins (AF) and ochratoxin A, assessed as the amount of AFM1 necessary to cause 50% inhibition of binding, was 5% for AFB1 and much less for AFB2, AFG1, and AFG2; there was no reaction with ochratoxin A. Aflatoxins 35-45 AFG1 like ATPase Homo sapiens 186-190 11829670-6 2002 The relative cross-reactivity with aflatoxins (AF) and ochratoxin A, assessed as the amount of AFM1 necessary to cause 50% inhibition of binding, was 5% for AFB1 and much less for AFB2, AFG1, and AFG2; there was no reaction with ochratoxin A. Aflatoxins 35-45 spermatogenesis associated 5 Homo sapiens 196-200 12325486-2 2002 There are four major natural occurring aflatoxins: B1, B2, G1 and G2. Aflatoxins 39-49 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 51-68 11665739-5 2001 The co-occurrence of the two carcinogenic mycotoxins aflatoxin B1 and fumonisin B1 was observed in 100% of the aflatoxin-contaminated samples (82 samples). Aflatoxins 53-62 anthocyanin regulatory R-S protein-like Zea mays 63-82 11526514-9 2001 These results are consistent with a role of aflatoxin B1 in the instability of chromosome 16q at the fragile site FRA16D. Aflatoxins 44-53 fragile site, aphidicolin type, common, fra(16)(q23.2) Homo sapiens 114-120 11685745-5 2001 Exposure to aflatoxin is associated with a specific mutation in the tumor-suppressor gene p53. Aflatoxins 12-21 tumor protein p53 Homo sapiens 90-93 11493326-4 2001 Much has been learned from molecular biological studies on hepatocarcinogenesis incriminating the HBX gene of HBV, the core protein of HCV and a unique guanine to thymine transversion at codon 249 has been observed in cases due to aflatoxin exposure. Aflatoxins 231-240 X protein Hepatitis B virus 98-101 11470760-6 2001 In addition, the effect of aflatoxin exposure on HCC risk was more pronounced among chronic HBsAg carriers with the GSTT1 null genotype (OR 3.7, 95% CI 1.5-9.3) than those who were non-null (OR 0.9, 95% CI 0.3-2.4). Aflatoxins 27-36 glutathione S-transferase theta 1 Homo sapiens 116-121 11470760-8 2001 For GSTM1 the effect of aflatoxin exposure on HCC risk in those with the null genotype was also greater (adjusted OR 2.8, 95% CI 1.0-7.8) than in those with the gene present (adjusted OR 1.8, 95% CI 0.8-4.5), but the difference was not significant (P = 0.91). Aflatoxins 24-33 glutathione S-transferase mu 1 Homo sapiens 4-9 11298941-2 2001 METHODS AND RESULTS: Two genes, nor1 and ver1, representing genes whose products are involved in early and late steps in aflatoxin biosynthesis, were examined. Aflatoxins 121-130 nuclear receptor subfamily 4 group A member 3 Homo sapiens 32-36 11819809-3 2001 Hepatitis B and C viruses (HBV and HCV) and dietary aflatoxin intake remain the major causative factors of HCC. Aflatoxins 52-61 HCC Homo sapiens 107-110 11401911-3 2001 A G to T transversion at codon 249 of the p53 gene (249(ser)) is commonly found in HCCs from patients in regions with dietary aflatoxin exposure. Aflatoxins 126-135 tumor protein p53 Homo sapiens 42-45 11401911-3 2001 A G to T transversion at codon 249 of the p53 gene (249(ser)) is commonly found in HCCs from patients in regions with dietary aflatoxin exposure. Aflatoxins 126-135 holocytochrome c synthase Homo sapiens 83-87 11401911-9 2001 Second, we present a meta-analysis, using our results along with those from 48 published studies, that examines the interrelationships among aflatoxin exposure, HBV infection, and p53 mutations in HCCs. Aflatoxins 141-150 tumor protein p53 Homo sapiens 180-183 11401911-9 2001 Second, we present a meta-analysis, using our results along with those from 48 published studies, that examines the interrelationships among aflatoxin exposure, HBV infection, and p53 mutations in HCCs. Aflatoxins 141-150 holocytochrome c synthase Homo sapiens 197-201 11401911-10 2001 We used a method that takes into account both within-study and study-to-study variability and found that the mean proportion of HCCs with the 249(ser) mutation was positively correlated with aflatoxin exposure (P = 0.0001). Aflatoxins 191-200 holocytochrome c synthase Homo sapiens 128-132 12525098-3 2001 The detection of aflatoxin-albumin adducts (AFB-ALB) in serum has been used to investigate the relationship between aflatoxin exposure and HCC. Aflatoxins 17-26 albumin Homo sapiens 48-51 11298941-4 2001 The product of nor1 is involved in the formation of norsolorinic acid, the first stable intermediate in the aflatoxin pathway. Aflatoxins 108-117 nuclear receptor subfamily 4 group A member 3 Homo sapiens 15-19 14510167-1 2001 Mutations of p53 tumour suppressor gene often occur in hepatocellular carcinoma and, in particular, codon 249 hot-spot mutation is displayed by hepatocellular carcinomas occurring in hepatitis B virus-endemic areas with high dietary aflatoxin intake. Aflatoxins 233-242 tumor protein p53 Homo sapiens 13-16 11220661-9 2001 Aflatoxin-related mutations at codon 249 of the p53 gene in plasma may be more relevant in this regard but their application requires further understanding of the temporal appearance of this biomarker in relation to the natural history of the disease. Aflatoxins 0-9 tumor protein p53 Homo sapiens 48-51 10706111-3 2000 Under the conditions used, the natural benzopyrone CMRN was a major inducer of the AFB1 aldehyde reductase (AFAR) and the aflatoxin-conjugating class-alpha GST A5 subunit in rat liver, causing elevations of between 25- and 35-fold in hepatic levels of these proteins. Aflatoxins 122-131 hematopoietic prostaglandin D synthase Rattus norvegicus 156-159 11185536-12 2000 Dietary aflatoxin exposure is an important codeterminant of HCC risk in Africa and parts of Asia. Aflatoxins 8-17 HCC Homo sapiens 60-63 10958934-13 2000 TP53 mutational analysis showed that both HKCI-1 and the primary tumor had the aflatoxin-associated mutation in codon 249 and an additional TP53 polymorphism in codon 72. Aflatoxins 79-88 tumor protein p53 Homo sapiens 0-4 11204238-1 2000 A one-dimensional TLC method to determine aflatoxins (B1, B2, G1, G2) in various food matrices was elaborated which abstains fully on the use of chlorinated solvents. Aflatoxins 42-52 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 54-68 10854630-1 2000 Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. Aflatoxins 95-104 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus 10-17 10826104-0 2000 Aflatoxins inhibit prolactin secretion by rat pituitary cells in culture. Aflatoxins 0-10 prolactin Rattus norvegicus 19-28 11104412-0 1999 Aflatoxin, Tobacco, Ammonia and the p53 Tumor-Suppressor Gene: Cancer"s Missing Link? Aflatoxins 0-9 tumor protein p53 Homo sapiens 36-39 10654919-1 1999 This chapter reviews the data that have been accumulated implicating aflatoxin ingestion as an important risk factor in the aetiology of hepatocellular carcinoma (HCC). Aflatoxins 69-78 HCC Homo sapiens 163-166 10654919-2 1999 Numerous epidemiological studies have observed a correlation between areas of high aflatoxin exposure and a high incidence of HCC. Aflatoxins 83-92 HCC Homo sapiens 126-129 18944733-1 1999 ABSTRACT In this study, we found that the inhibition of fungal growth in potato dextrose broth (PDB) medium by the 14-kDa corn trypsin inhibitor (TI) protein, previously found to be associated with host resistance to aflatoxin production and active against various fungi, was relieved when exogenous alpha-amylase was added along with TI. Aflatoxins 217-226 Bowman-Birk type bran trypsin inhibitor Zea mays 127-149 18944733-1 1999 ABSTRACT In this study, we found that the inhibition of fungal growth in potato dextrose broth (PDB) medium by the 14-kDa corn trypsin inhibitor (TI) protein, previously found to be associated with host resistance to aflatoxin production and active against various fungi, was relieved when exogenous alpha-amylase was added along with TI. Aflatoxins 217-226 alpha-amylase Zea mays 300-313 18944733-1 1999 ABSTRACT In this study, we found that the inhibition of fungal growth in potato dextrose broth (PDB) medium by the 14-kDa corn trypsin inhibitor (TI) protein, previously found to be associated with host resistance to aflatoxin production and active against various fungi, was relieved when exogenous alpha-amylase was added along with TI. Aflatoxins 217-226 Bowman-Birk type bran trypsin inhibitor Zea mays 146-148 18944734-0 1999 Amy1, the alpha-Amylase Gene of Aspergillus flavus: Involvement in Aflatoxin Biosynthesis in Maize Kernels. Aflatoxins 67-76 alpha-amylase Zea mays 10-23 18944734-2 1999 In this study, we characterized an alpha-amylase-deficient mutant and assessed its ability to infect and produce aflatoxin in wounded maize kernels. Aflatoxins 113-122 alpha-amylase Zea mays 35-48 18944734-6 1999 The alpha-amylase-deficient mutant produced aflatoxin in maize kernels with wounded embryos and occasionally produced aflatoxin only in embryos of kernels with wounded endosperm. Aflatoxins 44-53 alpha-amylase Zea mays 4-17 18944734-6 1999 The alpha-amylase-deficient mutant produced aflatoxin in maize kernels with wounded embryos and occasionally produced aflatoxin only in embryos of kernels with wounded endosperm. Aflatoxins 118-127 alpha-amylase Zea mays 4-17 18944734-9 1999 These results suggest that alpha-amylase facilitates aflatoxin production and growth of A. flavus from a wound in the endosperm to the embryo. Aflatoxins 53-62 alpha-amylase Zea mays 27-40 18944734-10 1999 A 14-kDa trypsin inhibitor associated with resistance to A. flavus and aflatoxin in maize also inhibited the alpha-amylase from A. flavus, indicating that it is a bifunctional inhibitor. Aflatoxins 71-80 alpha-amylase Zea mays 109-122 10960967-6 2000 Finally, aflatoxins have been shown to induce specific mutations of the p53 tumor suppressor gene, thus pointing to the contribution of environmental factors to tumor development at the molecular level. Aflatoxins 9-19 tumor protein p53 Homo sapiens 72-75 10545423-0 1999 Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People"s Republic of China. Aflatoxins 38-47 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 9-13 10545423-3 1999 This study was conducted to determine the effects of aflatoxin exposure, as measured by serum aflatoxin-albumin adduct levels, on somatic mutation frequency in the human hypoxanthine guanine phosphoribosyl transferase gene (HPRT). Aflatoxins 53-62 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 170-217 10545423-3 1999 This study was conducted to determine the effects of aflatoxin exposure, as measured by serum aflatoxin-albumin adduct levels, on somatic mutation frequency in the human hypoxanthine guanine phosphoribosyl transferase gene (HPRT). Aflatoxins 53-62 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 224-228 10545423-7 1999 An odds ratio of 19.3 (95% confidence interval 2.0, 183) was demonstrated for a high HPRT mutation frequency in individuals with high aflatoxin exposure compared with those with low aflatoxin exposure. Aflatoxins 134-143 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 85-89 10545423-7 1999 An odds ratio of 19.3 (95% confidence interval 2.0, 183) was demonstrated for a high HPRT mutation frequency in individuals with high aflatoxin exposure compared with those with low aflatoxin exposure. Aflatoxins 182-191 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 85-89 10545423-8 1999 This association indicates that aflatoxin-induced DNA damage in T lymphocytes, assessed using the validated surrogate albumin adduct markers, leads to increased mutations reflected as elevated HPRT gene mutations. Aflatoxins 32-41 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 193-197 10545423-9 1999 This cross-sectional study suggests the potential use of mutation frequency of the HPRT gene as a long-term biomarker of aflatoxin exposure in high risk populations. Aflatoxins 121-130 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 83-87 11104412-4 1999 Tobacco-related cancers, including those associated with ETS, often show the same p53 mutations associated with aflatoxin exposure. Aflatoxins 112-121 tumor protein p53 Homo sapiens 82-85 10389978-5 1999 All seven HCCs with a p53 mutation from Qidong and three of five from Shanghai had the aflatoxin-associated point mutation with a G to T transversion at codon 249, position 3. Aflatoxins 87-96 tumor protein p53 Homo sapiens 22-25 10223185-2 1999 Recently, we have shown that HGF has the capacity to induce both growth inhibition and programmed cell death in aflatoxin-transformed (AFLB8) rat liver epithelial cells. Aflatoxins 112-121 hepatocyte growth factor Rattus norvegicus 29-32 9006107-2 1996 A high rate of mutations in the p53 tumor suppressor gene in hepatocellular carcinomas of predominantly hepatitis B virus (HBV) carrier patients has been recently related to dietary aflatoxin. Aflatoxins 182-191 tumor protein p53 Homo sapiens 32-35 10374839-2 1999 An association has been detected between human exposure to aflatoxins, and mutations in the third base of codon 249 of the p53 gene in hepatomas. Aflatoxins 59-69 tumor protein p53 Homo sapiens 123-126 9519464-3 1998 Post-column derivatization with bromine allowed the simultaneous determination of aflatoxicol and aflatoxins B1, B2, G1, G2, M1, and Q1. Aflatoxins 98-108 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 109-119 9425920-2 1998 The mouse p53ser246 mutation is equivalent to the p53ser249 mutation found in human hepatomas associated with hepatitis B virus infection and aflatoxin exposure. Aflatoxins 142-151 transformation related protein 53, pseudogene Mus musculus 10-13 9425920-7 1998 Increased proliferation of hepatocytes, combined with no concomitant increase in apoptosis, may in part explain the enhanced development of hepatocellular carcinomas in p53-knockout and p53*-transgenic mice exposed to aflatoxin. Aflatoxins 218-227 transformation related protein 53, pseudogene Mus musculus 169-172 9425920-7 1998 Increased proliferation of hepatocytes, combined with no concomitant increase in apoptosis, may in part explain the enhanced development of hepatocellular carcinomas in p53-knockout and p53*-transgenic mice exposed to aflatoxin. Aflatoxins 218-227 transformation related protein 53, pseudogene Mus musculus 186-189 9414172-4 1997 The recently developed individual biochemical and molecular markers of aflatoxin exposure, i.e., aflatoxin-albumin adducts in blood and a specific GC to TA transversion mutation in codon 249 of the p53 gene (249ser p53 mutation) in hepatocellular carcinomas, permit a better quantitative estimation of aflatoxin exposure in different populations of the world. Aflatoxins 71-80 tumor protein p53 Homo sapiens 198-201 9419863-1 1997 Aflatoxins B1, B2, G1, and G2 were determined at parts-per-trillion levels in beer by immunoaffinity column cleanup and reversed-phase liquid chromatography (LC) with fluorescence detection after trifluoroacetic acid derivatization. Aflatoxins 0-10 membrane spanning 4-domains A1 Homo sapiens 11-29 9240448-3 1997 HGF caused a cytostatic effect and enhanced cell motility in spontaneously and aflatoxin-transformed cells. Aflatoxins 79-88 hepatocyte growth factor Rattus norvegicus 0-3 9187270-8 1997 ATP-dependent transport of unmodified aflatoxin B1 by MRP-enriched membrane vesicles was low but markedly enhanced in the presence of 5 mM GSH, even though GSH conjugates of aflatoxin B1 were not formed by the vesicles. Aflatoxins 38-47 ATP binding cassette subfamily C member 1 Homo sapiens 54-57 9143099-0 1997 ord1, an oxidoreductase gene responsible for conversion of O-methylsterigmatocystin to aflatoxin in Aspergillus flavus. Aflatoxins 87-96 DNA-binding transcription repressor IXR1 Saccharomyces cerevisiae S288C 0-4 9143099-8 1997 The data indicate that ord1 is sufficient to accomplish the last step of the aflatoxin biosynthetic pathway. Aflatoxins 77-86 DNA-binding transcription repressor IXR1 Saccharomyces cerevisiae S288C 23-27 9163674-9 1997 It appears that, in contrast to the frequently reported G-->T transversions in codon 249 of the p53 gene in primary hepatomas in aflatoxin-exposed humans, the failure to detect Ha-ras mutations in these tumours is not due to an inability of aflatoxin B1 to activate this proto-oncogene. Aflatoxins 132-141 tumor protein p53 Homo sapiens 99-102 10064859-13 1999 More strikingly, the relationship between aflatoxin exposure and development of human hepatocellular carcinoma (HHC) was demonstrated by the studies on the p53 tumor suppressor gene. Aflatoxins 42-51 tumor protein p53 Homo sapiens 156-159 10064859-14 1999 High frequency of p53 mutations (G-->T transversion at codon 249) was found to occur in HHC collected from populations exposed to high levels of dietary aflatoxin in China and Southern Africa. Aflatoxins 156-165 tumor protein p53 Homo sapiens 18-21 9769950-3 1997 A specific mutation at codon 249 (AGG-->AGT) was found at high frequency in tumors from high aflatoxin-areas. Aflatoxins 96-105 angiotensinogen Homo sapiens 43-46 9240448-6 1997 In the aflatoxin transformed cells HGF also induced apoptosis, associated with constitutive c-myc expression and 1 Kb bax-alpha transcripts. Aflatoxins 7-16 hepatocyte growth factor Rattus norvegicus 35-38 9240448-6 1997 In the aflatoxin transformed cells HGF also induced apoptosis, associated with constitutive c-myc expression and 1 Kb bax-alpha transcripts. Aflatoxins 7-16 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 92-97 9189703-0 1997 Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure? Aflatoxins 85-94 tumor protein p53 Homo sapiens 25-28 9189703-7 1997 Patients from areas with high aflatoxin levels were more likely to have p53 mutations than were patients from areas with low aflatoxin levels. Aflatoxins 30-39 tumor protein p53 Homo sapiens 72-75 9189703-8 1997 In the group with p53 mutations, patients from areas with high aflatoxin levels had higher proportions of mutations with codon 249 G > T transversions. Aflatoxins 63-72 tumor protein p53 Homo sapiens 18-21 9189703-10 1997 Aflatoxin may increase the proportion of p53 mutations by causing a single mutation, the codon 249 G > T transversion, thus explaining some of the excess liver cancer associated with aflatoxin exposure. Aflatoxins 0-9 tumor protein p53 Homo sapiens 41-44 9189703-10 1997 Aflatoxin may increase the proportion of p53 mutations by causing a single mutation, the codon 249 G > T transversion, thus explaining some of the excess liver cancer associated with aflatoxin exposure. Aflatoxins 186-195 tumor protein p53 Homo sapiens 41-44 9006107-9 1996 Overall, our findings indicate that in woodchucks and in ground squirrels exposure to aflatoxin may affect the development of p53 mutations less than in humans. Aflatoxins 86-95 tumor protein p53 Homo sapiens 126-129 8975785-1 1996 The combined presence of CYP1A2 and 3A4, both of which oxidize aflatoxin B1 (AFB1) to the reactive aflatoxin B1-8,9-epoxide (AFBO) and to hydroxylated inactivation products aflatoxin M1 (AFM1) and aflatoxin Q1 (AFQ1), substantially complicates the kinetic analysis of AFB1 oxidation in human liver microsomes. Aflatoxins 63-72 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 25-31 8921985-5 1996 The most significant finding is that more than 50% of HCC patients from high aflatoxin exposure areas such as southern Africa and Qidong, China harboured a codon 249 G to T transversion in the p53 tumor suppressor gene, which is found to be consistent with the mutagenic specificity of AFB1 observed in vitro. Aflatoxins 77-86 tumor protein p53 Homo sapiens 193-196 8910329-1 1996 The binding of two different reaction products (p-nitrobenzyl glutathione and the aflatoxin-glutathione conjugate) to mouse glutathione S-transferase A3-3 (mGSTA3-3) has been measured using equilibrium dialysis and a direct fluorescence quenching technique. Aflatoxins 82-91 glutathione S-transferase, alpha 3 Mus musculus 156-164 8735774-2 1996 Pure aflatoxins (B1, B2, G1 and G2) were individually coated on a silica gel and exposed to microwaves at various power settings and periods. Aflatoxins 5-15 anthocyanin regulatory R-S protein-like Zea mays 17-34 23604654-1 1996 The effect of processing steps as well preservatives used in French bread making namely propionic acid and/or potassium sorbate (0.2%) on the destruction of aflatoxins B1 and G1 was studied.Mixing and baking processes showed marked destruction of aflatoxins B1 and G1; being 71.2% and 52.5% for aflatoxin B1 after mixing and baking steps, while reaching 73.9% and 54.5% for aflatoxin G1. Aflatoxins 157-167 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 168-177 23604654-2 1996 Fermentation step caused additional 15.3% and 15.0% destruction of aflatoxins B1 and G1.On the other hand, aflatoxin B1 destruction was 79.2% and 50.7% when propionic acid was used and 75.3 and 56.7% in the presence of potassium sorbate and after mixing and baking steps respectively.Concerning aflatoxins G1 it was found that mixing and baking steps showed destruction of 81.9% and 53.4% in the presence of propionic acid and 75.1 and 49.4% in the presence of potassium sorbate in this respective order.Generally, it can be concluded that using propionic acid as preservative appeared to be more effective on the destruction of aflatoxins B1 and G1 than potassium sorbate in French bread making. Aflatoxins 67-77 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 78-87 8659516-0 1996 Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. Aflatoxins 121-130 glutathione S-transferase mu 1 Homo sapiens 52-80 8659516-1 1996 This study was carried out to elucidate the effect of glutathione S-transferase (GST) Ml and Tl polymorphisms on the aflatoxin-related hepatocarcinogenesis among chronic carriers of hepatitis B surface antigen (HBsAg). Aflatoxins 117-126 glutathione S-transferase kappa 1 Homo sapiens 54-79 8659516-1 1996 This study was carried out to elucidate the effect of glutathione S-transferase (GST) Ml and Tl polymorphisms on the aflatoxin-related hepatocarcinogenesis among chronic carriers of hepatitis B surface antigen (HBsAg). Aflatoxins 117-126 glutathione S-transferase kappa 1 Homo sapiens 81-84 8779543-0 1996 Immunochemical and genetic analysis of the p53 gene in liver preneoplastic nodules from aflatoxin-induced rats in one year. Aflatoxins 88-97 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 43-46 8640905-0 1996 An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Aflatoxins 3-12 tumor protein p53 Homo sapiens 63-66 8920133-1 1996 Immunoaffinity column-based sample preparation procedures for determination of aflatoxins B1, B2, G1, and G2 in several food matrixes and aflatoxin M1 in milk have been automated by using flexible automation, or robotics. Aflatoxins 79-88 anthocyanin regulatory R-S protein-like Zea mays 90-108 8920133-5 1996 Mean recoveries of aflatoxins B1, B2, and G1 added to corn and nuts at 9-36 ng/g total aflatoxins were > 85% (coefficient of variation [CV] = 16%). Aflatoxins 19-29 anthocyanin regulatory R-S protein-like Zea mays 30-44 31159058-0 1996 Reduction of Carryover of Aflatoxin from Cow Feed to Milk by Addition of Activated Carbons. Aflatoxins 26-35 Weaning weight-maternal milk Bos taurus 53-57 8929859-6 1996 When sera of malnourished patients were mixed with adult control sera, incubated for 5 h at 37 degrees C, and assessed by ligand blotting, a low IGFBP-3 level in marasmus was found to be due to increased adaptive proteolysis of IGFBP-3; in contrast, in kwashiorkor the IGFBP-3 proteolytic activity was very low, probably because of inhibition by aflatoxins. Aflatoxins 346-356 insulin like growth factor binding protein 3 Homo sapiens 145-152 8817938-1 1996 To evaluate the rate at which the four main aflatoxins (aflatoxins B1, B2, G1 and G2) are able to cross the luminal membrane of the rat small intestine, a study about intestinal absorption kinetics of these mycotoxins has been made. Aflatoxins 44-54 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus 67-84 7578001-9 1995 The extra adenine A16 was inserted between base pair AFBG6.C15 and the aflatoxin moiety. Aflatoxins 71-80 immunoglobulin kappa variable 3-31 (pseudogene) Homo sapiens 18-21 8526867-0 1995 Substrate specificity of an aflatoxin-metabolizing aldehyde reductase. Aflatoxins 28-37 aldo-keto reductase family 1, member B7 Rattus norvegicus 51-69 7578001-11 1995 The aflatoxin moiety stacked below the top domain of the oligodeoxynucleotide, which consisted of base pairs C1.G21, C2.G20, A3.T19, T4.A18, and C5.G17. Aflatoxins 4-13 immunoglobulin kappa variable 2-29 Homo sapiens 136-139 7557882-1 1995 The p53 gene is frequently mutated in human tumors; in hepatocellular carcinomas, there is a high frequency of a specific mutation at codon 249 in regions with significant aflatoxin exposure. Aflatoxins 172-181 tumor protein p53 Homo sapiens 4-7 8541111-4 1995 The detection of p53 in a relatively high percentage of the HCC cases in Hungary, a country in which aflatoxin contamination of the diet is rare, suggests that factors other than aflatoxin led to the accumulation or overexpression of p53 in these patients. Aflatoxins 101-110 tumor protein p53 Homo sapiens 17-20 7709595-3 1995 After glucose challenge the ratios between 0-h and 2-h serum glucose levels were significantly higher than controls, indicating an increase in tolerance of glucose in the aflatoxin-fed mice with lower glyoxalase-I activity. Aflatoxins 171-180 glyoxalase 1 Mus musculus 201-213 7605578-0 1995 Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Aflatoxins 125-134 transformation related protein 53, pseudogene Mus musculus 29-32 7605578-0 1995 Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Aflatoxins 125-134 tumor protein p53 Homo sapiens 70-73 7605578-1 1995 A mutation in the tumor suppressor p53 gene resulting in an Arg-->Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure. Aflatoxins 204-213 tumor protein p53 Homo sapiens 35-38 7614019-4 1995 At all doses the aflatoxin caused decreases in serum total proteins, albumin: globulin ratio, serum total cholesterol, serum calcium and phosphorus and increase in serum globulins, alanine amino transferase (ALT) and aspartate amino transferase (AST) concentrations. Aflatoxins 17-26 glutamic--pyruvic transaminase Homo sapiens 181-206 7614019-4 1995 At all doses the aflatoxin caused decreases in serum total proteins, albumin: globulin ratio, serum total cholesterol, serum calcium and phosphorus and increase in serum globulins, alanine amino transferase (ALT) and aspartate amino transferase (AST) concentrations. Aflatoxins 17-26 glutamic--pyruvic transaminase Homo sapiens 208-211 7614019-4 1995 At all doses the aflatoxin caused decreases in serum total proteins, albumin: globulin ratio, serum total cholesterol, serum calcium and phosphorus and increase in serum globulins, alanine amino transferase (ALT) and aspartate amino transferase (AST) concentrations. Aflatoxins 17-26 solute carrier family 17 member 5 Homo sapiens 217-244 7614019-4 1995 At all doses the aflatoxin caused decreases in serum total proteins, albumin: globulin ratio, serum total cholesterol, serum calcium and phosphorus and increase in serum globulins, alanine amino transferase (ALT) and aspartate amino transferase (AST) concentrations. Aflatoxins 17-26 solute carrier family 17 member 5 Homo sapiens 246-249 7664937-0 1995 Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: lack of association. Aflatoxins 7-16 tumor protein p53 Homo sapiens 65-68 7664937-1 1995 Experiments were done to show whether a G to T mis-sense mutation at the third base of codon 249 of the p53 tumour suppressor gene is a "hot spot" of aflatoxin attack as suggested by the results of epidemiological studies. Aflatoxins 150-159 tumor protein p53 Homo sapiens 104-107 7757303-5 1995 Sequence analysis of p53 cDNA revealed a homozygous double mutation at codon 249 (commonly mutated in aflatoxin-associated hepatocellular carcinoma) and codon 250. Aflatoxins 102-111 tumor protein p53 Homo sapiens 21-24 7783781-4 1995 Aflatoxins (B1, B2, G1 and G2) were not present in the firm or shrivelled ripe figs. Aflatoxins 0-10 membrane spanning 4-domains A1 Homo sapiens 12-29 8682610-6 1995 HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC. Aflatoxins 20-30 HCC Homo sapiens 124-127 8012215-10 1994 This method was adopted first action by AOAC INTERNATIONAL as a change in method for 990.34 for screening for aflatoxins B1, B2, and G1 in corn at total aflatoxin concentrations of > or = 20 ng/g. Aflatoxins 110-119 anthocyanin regulatory R-S protein-like Zea mays 121-135 7923176-2 1994 Recently, a broad range of mutations in the p53 tumor suppressor gene has been reported in human HCCs, predominantly from hepatitis B virus carriers in areas with either high or low levels of exposure to dietary aflatoxin. Aflatoxins 212-221 tumor protein p53 Homo sapiens 44-47 7923176-12 1994 In view of the considerably lower apparent rate of mutations in comparison to human HCCs, we suggest a less important role for aflatoxin in the induction of p53 mutations in HCCs of ground squirrels. Aflatoxins 127-136 tumor protein p53 Homo sapiens 157-160 7532124-1 1994 To find out if the presumed intake of dietary aflatoxins (AFB1 and AFG1) has adverse effect on the liver of Ghanaians, the toxins were measured in serum, urine and faecal specimens obtained from a group of apparently healthy Ghanaian adults. Aflatoxins 46-56 AFG1 like ATPase Homo sapiens 67-71 7955067-8 1994 To demonstrate the program, the mutational spectra of single base substitutions in the p53 gene are compared in (i) bladder cancers from smokers and non-smokers, (ii) small-cell lung cancers, non-small-cell lung cancers and colon cancers and (iii) hepatocellular carcinomas from high- and low-aflatoxin exposure groups. Aflatoxins 293-302 tumor protein p53 Homo sapiens 87-90 8062243-1 1994 Mice are resistant to aflatoxin carcinogenicity primarily due to expression of a glutathione S-transferase (mYc) with high catalytic activity toward aflatoxin B1-8,9-epoxide (AFBO). Aflatoxins 22-31 myelocytomatosis oncogene Mus musculus 108-111 8062243-2 1994 In contrast, rats are more sensitive to aflatoxin carcinogenicity due to the constitutive expression of a glutathione S-transferase with relatively low catalytic activity toward AFBO (rYc1). Aflatoxins 40-49 glutathione S-transferase alpha 1 Rattus norvegicus 184-188 8033311-1 1994 Dietary aflatoxin and hepatitis B virus infection may play a role in generating the p53 tumor suppressor gene codon 249 hotspot mutation found in human hepatocellular carcinomas (HCCs) from Qidong (China) and southern Africa. Aflatoxins 8-17 tumor protein p53 Homo sapiens 84-87 8056674-6 1994 Aflatoxin elevated (P < .01) aspartate amino transferase and gamma-glutamyl transferase activities and total protein and cholesterol concentrations while decreasing (P < .05) alkaline phosphatase, glucose, cholinesterase, albumin, inorganic phosphorus, iron, and total-iron-binding capacity. Aflatoxins 0-9 cholinesterase Ovis aries 212-226 8307460-1 1994 p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Aflatoxins 90-99 tumor protein p53 Homo sapiens 0-3 8290606-6 1994 Mozambican-type of hepatocellular carcinomas are characterized by a high incidence of p53 mutations related to aflatoxins. Aflatoxins 111-121 tumor protein p53 Homo sapiens 86-89 8261428-4 1994 Formation of the hydroxylated metabolite aflatoxin M1 (AFM1) was observed only in the CYP1A2 microsomes whereas aflatoxin Q1 (AFQ1) production was observed exclusively in the CYP3A4 microsomes. Aflatoxins 41-50 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 86-92 8261428-4 1994 Formation of the hydroxylated metabolite aflatoxin M1 (AFM1) was observed only in the CYP1A2 microsomes whereas aflatoxin Q1 (AFQ1) production was observed exclusively in the CYP3A4 microsomes. Aflatoxins 112-121 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 175-181 8307460-6 1994 This study shows that p53 mutations are a rare event in hepatocarcinogenesis in Great Britain, an area of low aflatoxin exposure, and supports the concept of geographical variations in the cause and pathogenesis of hepatocellular carcinoma. Aflatoxins 110-119 tumor protein p53 Homo sapiens 22-25 8390289-1 1993 In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. Aflatoxins 140-149 tumor protein p53 Homo sapiens 49-52 8238731-1 1993 In areas of the world where hepatitis B and aflatoxin ingestion are common, alterations of the p53 tumor suppressor gene have frequently been reported in hepatocellular carcinoma (HCC). Aflatoxins 44-53 tumor protein p53 Homo sapiens 95-98 8269634-4 1993 Microsomal metabolism of AFB1 to AFB1 8,9-epoxide (as measured by AFB1 tris-diol formation) and aflatoxin Q1 (AFQ1), the major metabolite produced, was significantly correlated with CYP3A3/4 expression (P < 0.001) and, to a lesser extent, with CYP2B6 expression (P < 0.01). Aflatoxins 96-105 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 182-188 8269634-4 1993 Microsomal metabolism of AFB1 to AFB1 8,9-epoxide (as measured by AFB1 tris-diol formation) and aflatoxin Q1 (AFQ1), the major metabolite produced, was significantly correlated with CYP3A3/4 expression (P < 0.001) and, to a lesser extent, with CYP2B6 expression (P < 0.01). Aflatoxins 96-105 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 247-253 8100480-1 1993 BACKGROUND: p53 gene mutations at codon 249 have been reported in hepatocellular carcinoma (HCC) from China and South Africa, a phenomenon shown to be closely associated with food contamination by aflatoxin. Aflatoxins 197-206 tumor protein p53 Homo sapiens 12-15 8376505-2 1993 Aflatoxins B1, B2, G1 and G2 are captured on C2 extraction columns and simultaneously cleaned up with the aid of a robotic system. Aflatoxins 0-10 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 11-28 8790556-5 1994 Aflatoxins have been shown to induce specific mutations of the p53 tumour suppressor gene thus providing a clue to how an environmental factor may contribute to tumour development at the molecular level. Aflatoxins 0-10 tumor protein p53 Homo sapiens 63-66 8390289-2 1993 As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we screened 15 liver cancer samples from this country for mutation at codon 249 of the p53 gene. Aflatoxins 127-136 tumor protein p53 Homo sapiens 225-228 8093978-2 1993 Recently, there have been reports that p53 mutations are found to occur at high frequency (50%) in aflatoxin-related human primary hepatocellular carcinomas (HCC) (Hsu et al., 1991 Nature, vol 350, p. 427; Bressac et al., 1991 Nature, vol 350, p. 429). Aflatoxins 99-108 tumor protein p53 Homo sapiens 39-42 8393124-6 1993 These results suggest a role for other environmental factors, such as aflatoxin, in the etiology of p53 mutation in hepatocellular carcinoma in Oriental patients. Aflatoxins 70-79 tumor protein p53 Homo sapiens 100-103 1279184-0 1992 Mutations of p53 gene in hepatocellular carcinoma: roles of hepatitis B virus and aflatoxin contamination in the diet. Aflatoxins 82-91 tumor protein p53 Homo sapiens 13-16 7583984-5 1993 In addition, the tumor suppressor gene p53 is frequently mutated in aflatoxin-induced hepatoma. Aflatoxins 68-77 tumor protein p53 Homo sapiens 39-42 1332921-7 1992 They support the suggestion of a possible link between dietary exposure to aflatoxin and selective G to T mutations at codon 249 of the p53 gene. Aflatoxins 75-84 tumor protein p53 Homo sapiens 136-139 8243107-1 1993 The effect of oral consumption of 200 +/- 100 ppb of crude aflatoxin (B1, B2, G1, G2) showed testicular degeneration and a decrease in the meiotic index. Aflatoxins 59-68 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus 70-84 1279184-2 1992 These reports suggested an association of p53 mutations with high levels of aflatoxin in the diet. Aflatoxins 76-85 tumor protein p53 Homo sapiens 42-45 1279184-5 1992 PURPOSE: The purpose of this study was to evaluate the relationship of p53 gene mutation to high or low levels of aflatoxin in the diet and to HBV infection. Aflatoxins 114-123 tumor protein p53 Homo sapiens 71-74 1279184-11 1992 CONCLUSION: Mutations of the tumor suppressor gene p53 in hepatocellular carcinomas are not limited to patients from geographic regions where the ingestion of aflatoxin is high. Aflatoxins 159-168 tumor protein p53 Homo sapiens 51-54 1394191-11 1992 The finding of transition mutations exclusively at GG sites may be of predictive value in attempts to link dietary aflatoxin exposure to cancers associated with specific mutations in the c-ras oncogene and the p53 tumor suppressor gene. Aflatoxins 115-124 tumor protein p53 Homo sapiens 210-213 1330867-6 1992 Our results showed that p53-positive hepatocellular carcinoma is a rare finding in patients exposed to a low dietary aflatoxin intake and that p53 mutation seems to occur at a late stage of the tumoral process and could contribute to an aggressive tumoral phenotype. Aflatoxins 117-126 tumor protein p53 Homo sapiens 24-27 1737362-10 1992 These results suggest that an overexpression of PKC alpha may play a role in the altered biological properties of aflatoxin-transformed 10T1/2 cells. Aflatoxins 114-123 protein kinase C, alpha Mus musculus 48-57 1306334-3 1992 Different P450 forms are responsible for activation of the various classes of chemical carcinogens including the arylamines, polycyclic aromatic hydrocarbons, nitrosamines and aflatoxins. Aflatoxins 176-186 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 10-14 1637297-4 1992 The primary structure of the murine GST Yc subunit predicted by pmusGST Yc is in complete agreement with the partial amino acid sequence of the aflatoxin-metabolizing mouse liver GST described previously [McLellan, Kerr, Cronshaw & Hayes (1991) Biochem. Aflatoxins 144-153 hematopoietic prostaglandin D synthase Mus musculus 36-39 1441760-2 1992 Aflatoxins B1, B2, G1, and G2, are extracted by methanol/water (85 + 15) and partitioned into methylene dichloride. Aflatoxins 0-10 anthocyanin regulatory R-S protein-like Zea mays 11-29 1344831-4 1992 Omeprazole interacts with the cytochrome P-450 system in the liver: inhibition of several liver mono-oxygenases activities (inhibitory effect on diazepam, phenytoin and R-warfarin metabolism with prolonged elimination); induction of P-450 (IA1 and IA2) enzymes that may potentiate the hepatotoxic effect of phenacetin and acetaminophen or increase the tumorigenic effect of chemical carcinogens (polycyclic aromatic hydrocarbons, arylamines, aflatoxin). Aflatoxins 442-451 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-46 1347900-0 1992 p53 codon 249ser mutations in hepatocellular carcinoma patients with low aflatoxin exposure. Aflatoxins 73-82 tumor protein p53 Homo sapiens 0-3 1310637-7 1992 The occurrence of mutation in codon 249 of the p53 gene in selective samples of human hepatocellular cancers may indicate involvement of environmental carcinogens other than aflatoxin B1 or that hepatitis B virus-related hepatitis is a prerequisite for aflatoxin B1 induction of G to T transversion in codon 249. Aflatoxins 174-183 tumor protein p53 Homo sapiens 47-50 1332185-3 1992 Recent reports of a guanine to thymine mutation of the third base of codon 249 of the tumour suppressor gene, p53, in 50% of patients with hepatocellular carcinoma in regions of high aflatoxin exposure, and mutagenic experiments showing that aflatoxin B1 binds particularly to guanine residues in G-C-rich domains and that codon 249 is a preferred target have suggested a mechanism whereby aflatoxin might induce malignant transformation. Aflatoxins 183-192 tumor protein p53 Homo sapiens 110-113 1332185-3 1992 Recent reports of a guanine to thymine mutation of the third base of codon 249 of the tumour suppressor gene, p53, in 50% of patients with hepatocellular carcinoma in regions of high aflatoxin exposure, and mutagenic experiments showing that aflatoxin B1 binds particularly to guanine residues in G-C-rich domains and that codon 249 is a preferred target have suggested a mechanism whereby aflatoxin might induce malignant transformation. Aflatoxins 242-251 tumor protein p53 Homo sapiens 110-113 1682737-0 1991 p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Aflatoxins 47-56 tumor protein p53 Homo sapiens 0-3 1631352-3 1992 Although aflatoxins have caused acute liver disease in humans, epidemiologic evidence of the involvement of aflatoxins in PLC has not been clarified. Aflatoxins 108-118 heparan sulfate proteoglycan 2 Homo sapiens 122-125 1788537-0 1991 Determination of exposure to aflatoxins among Danish workers in animal-feed production through the analysis of aflatoxin B1 adducts to serum albumin. Aflatoxins 29-39 albumin Homo sapiens 135-148 1788537-2 1991 Aflatoxin bound to serum albumin was therefore measured for feed-processing workers. Aflatoxins 0-9 albumin Homo sapiens 19-32 1682737-9 1991 A codon 249 mutation of the p53 gene identifies an endemic form of HCC strongly associated with dietary aflatoxin intake. Aflatoxins 104-113 tumor protein p53 Homo sapiens 28-31 1899057-0 1991 Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins. Aflatoxins 113-123 AFG1 like ATPase Homo sapiens 21-33 1908454-3 1991 To improve sensitivity, the urine filtrate is passed through a C18 solid phase column to extract the aflatoxin. Aflatoxins 101-110 Bardet-Biedl syndrome 9 Homo sapiens 63-66 23605655-3 1991 Aflatoxins (B1, B2, G1, and G2) were present in 29% of the samples examined at 0.5-63.0, 0.5-37.7, 0.5-78.3, and 0.5-12.5mu/kg, respectively. Aflatoxins 0-10 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 12-30 1892933-7 1991 Aflatoxin increased serum values of creatinine and gamma glutamyl transferase, cholinesterase, and alkaline phosphatase activities; increased packed cell volume and hemoglobin; and decreased urea nitrogen and total iron binding capacity. Aflatoxins 0-9 cholinesterase Sus scrofa 79-93 2317812-5 1990 ), 6: 693-697, 1985] suggested that the detoxication of aflatoxin through conjugation with glutathione is principally catalyzed by GST homodimer YaYa, we have investigated the regulation of the gene coding for the Ya subunit in the liver of F344 rats following dietary administration of oltipraz. Aflatoxins 56-65 hematopoietic prostaglandin D synthase Rattus norvegicus 131-134 2165416-2 1990 2 This assay, previously validated using spiked sera, provides a sensitive rapid determination of serum aflatoxin (B1, G1 and Q1). Aflatoxins 104-113 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 115-128 2363675-0 1990 Preferential over-expression of the class alpha rat Ya2 glutathione S-transferase subunit in livers bearing aflatoxin-induced pre-neoplastic nodules. Aflatoxins 108-117 hematopoietic prostaglandin D synthase Rattus norvegicus 56-81 34869462-3 2021 Methods: Experimental design was done by adding maximum allowed concentration of aflatoxins (B1, B2, G1, G2) and OchA according to the European Pharmacopeia related to cannabis flowers. Aflatoxins 81-91 membrane spanning 4-domains A1 Homo sapiens 93-103 33823938-0 2021 The Fungi-specific histone Acetyltransferase Rtt109 mediates morphogenesis, Aflatoxin synthesis and pathogenicity in Aspergillus flavus by acetylating H3K9. Aflatoxins 76-85 H3 histone acetyltransferase RTT109 Saccharomyces cerevisiae S288C 45-51 33823938-7 2021 The amount of aflatoxins synthesized by rtt109 in the PDB liquid medium was significantly decreased We also found that the rtt109 strain was extremely sensitive to DNA damage stress. Aflatoxins 14-24 H3 histone acetyltransferase RTT109 Saccharomyces cerevisiae S288C 41-47 33823938-7 2021 The amount of aflatoxins synthesized by rtt109 in the PDB liquid medium was significantly decreased We also found that the rtt109 strain was extremely sensitive to DNA damage stress. Aflatoxins 14-24 H3 histone acetyltransferase RTT109 Saccharomyces cerevisiae S288C 125-131 33823938-10 2021 In conclusion, Rtt109 participated in the growth, conidium formation, sclerotia generation, aflatoxin synthesis, environmental stress response, regulation of infection of A. flavus. Aflatoxins 92-101 H3 histone acetyltransferase RTT109 Saccharomyces cerevisiae S288C 15-21 2109192-2 1990 It is of special interest that adults and larvae possess cytochrome P-450-dependent activation systems able to metabolize most promutagens, e.g., nitrosamines, aflatoxins, pyrrolizidine alkaloids, safrole, etc. Aflatoxins 160-170 Cytochrome P450-4g1 Drosophila melanogaster 57-73 2157698-11 1990 The method has been adopted official first action for the determination of aflatoxins B1, B2, G1, and G2 in peanut butter and corn at concentrations greater than or equal to 13 ng total aflatoxins/g. Aflatoxins 75-85 anthocyanin regulatory R-S protein-like Zea mays 86-104 34517582-8 2021 The method was able to monitor the total aflatoxins content of food samples with a linear range of 0.05-8 ng mL-1, which was more sensitive than the fluorometric system without extraction (5-500 ng mL-1). Aflatoxins 41-51 L1 cell adhesion molecule Mus musculus 109-113 34517582-8 2021 The method was able to monitor the total aflatoxins content of food samples with a linear range of 0.05-8 ng mL-1, which was more sensitive than the fluorometric system without extraction (5-500 ng mL-1). Aflatoxins 41-51 L1 cell adhesion molecule Mus musculus 198-202 35636188-2 2022 Herein, we report the development of a noncompetitive immunoassay for aflatoxins based on a monoclonal capture antibody and a unique anti-immunocomplex (anti-IC) antibody fragment (scFv) isolated from a synthetic antibody repertoire. Aflatoxins 70-80 immunglobulin heavy chain variable region Homo sapiens 181-185 34345733-0 2021 Investigation on electronic structure, vibrational spectra, NBO analysis, and molecular docking studies of aflatoxins and selected emerging mycotoxins against wild-type androgen receptor. Aflatoxins 107-117 androgen receptor Homo sapiens 169-186 34170471-12 2021 This indicates the possible use of CYP1A1, NQO1, MT1A, and HSP70 as potential biomarkers for the exposure of the cattle to AFTs, Pb, and Cd. Aflatoxins 123-127 cytochrome P450 1A1 Bos taurus 35-41 34170471-12 2021 This indicates the possible use of CYP1A1, NQO1, MT1A, and HSP70 as potential biomarkers for the exposure of the cattle to AFTs, Pb, and Cd. Aflatoxins 123-127 NAD(P)H quinone dehydrogenase 1 Bos taurus 43-47 34170471-12 2021 This indicates the possible use of CYP1A1, NQO1, MT1A, and HSP70 as potential biomarkers for the exposure of the cattle to AFTs, Pb, and Cd. Aflatoxins 123-127 metallothionein-1A Bos taurus 49-53 34170471-12 2021 This indicates the possible use of CYP1A1, NQO1, MT1A, and HSP70 as potential biomarkers for the exposure of the cattle to AFTs, Pb, and Cd. Aflatoxins 123-127 heat shock 70 kDa protein 1B Bos taurus 59-64 34842380-6 2021 The obtained qPCR results showed a significant up regulation in the expression of Cyp3A6, HO-1, TNFalpha and NFKB genes in the liver of rats treated with aflatoxin. Aflatoxins 154-163 heme oxygenase 1 Rattus norvegicus 90-94 34842380-6 2021 The obtained qPCR results showed a significant up regulation in the expression of Cyp3A6, HO-1, TNFalpha and NFKB genes in the liver of rats treated with aflatoxin. Aflatoxins 154-163 tumor necrosis factor Rattus norvegicus 96-104 34842380-6 2021 The obtained qPCR results showed a significant up regulation in the expression of Cyp3A6, HO-1, TNFalpha and NFKB genes in the liver of rats treated with aflatoxin. Aflatoxins 154-163 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 109-113 34842380-7 2021 In contrast, there is a significant down regulation in the expression levels of the Glut2 gene in liver rats treated with aflatoxin. Aflatoxins 122-131 solute carrier family 2 member 2 Rattus norvegicus 84-89 35636188-4 2022 The single-step assay developed in this work, with a detection limit of 70 pg mL-1, could detect aflatoxins within 15 min. Aflatoxins 97-107 L1 cell adhesion molecule Mus musculus 78-82 35594247-7 2022 Then, 30 CF samples were collected and the level of aflatoxins (AFB1, AFB2, AFG1, and AFG2) was determined using a validated method. Aflatoxins 52-62 AFG1 like ATPase Homo sapiens 76-80 35353940-1 2022 A temperature-induced counter current homogenous liquid-liquid extraction procedure performed in a burette has been proposed for the isolation of aflatoxins B1, B2, G1, and G2 from various fruit chip samples. Aflatoxins 146-156 membrane spanning 4-domains A1 Homo sapiens 157-167 35594247-7 2022 Then, 30 CF samples were collected and the level of aflatoxins (AFB1, AFB2, AFG1, and AFG2) was determined using a validated method. Aflatoxins 52-62 spermatogenesis associated 5 Homo sapiens 86-90 35057950-0 2022 Peltier thermoelectric cooler improves both the signal-to-noise ratio and warm-up time of high-power LED induced fluorescence detector and application to aflatoxins. Aflatoxins 154-164 small integral membrane protein 10 like 2A Homo sapiens 101-104 35526302-2 2022 The proposed method was used to extract and enrich aflatoxins (B1, B2, G1, and G2) from soy milk samples before their quantification by high performance liquid chromatography-tandem mass spectrometry. Aflatoxins 51-61 membrane spanning 4-domains A1 Homo sapiens 63-81 35622554-3 2022 More than eighteen different types of aflatoxins have been reported to date, and among them, aflatoxins B1, B2, G1, and G2 are the most prevalent and lethal. Aflatoxins 38-48 membrane spanning 4-domains A1 Homo sapiens 104-114 35622554-3 2022 More than eighteen different types of aflatoxins have been reported to date, and among them, aflatoxins B1, B2, G1, and G2 are the most prevalent and lethal. Aflatoxins 93-103 membrane spanning 4-domains A1 Homo sapiens 104-114 35085253-2 2022 OBJECTIVE: This prospective study was conducted to examine the association of aflatoxin levels with CD4 T-cell count and antiretroviral therapy uptake over time. Aflatoxins 78-87 CD4 molecule Homo sapiens 100-103 35085253-10 2022 CONCLUSION: Consistent correlations of higher aflatoxin B1 adduct levels with lower CD4 over time indicate that there is an independent early and prolonged effect of aflatoxin on CD4 even with the initiation of antiretroviral therapy. Aflatoxins 166-175 CD4 molecule Homo sapiens 84-87 35051035-2 2022 The broadly accepted method to assess chronic human aflatoxin exposure is by quantifying the amount of aflatoxin adducted to human serum albumin. Aflatoxins 52-61 albumin Homo sapiens 131-144 35085253-10 2022 CONCLUSION: Consistent correlations of higher aflatoxin B1 adduct levels with lower CD4 over time indicate that there is an independent early and prolonged effect of aflatoxin on CD4 even with the initiation of antiretroviral therapy. Aflatoxins 166-175 CD4 molecule Homo sapiens 179-182 35051035-2 2022 The broadly accepted method to assess chronic human aflatoxin exposure is by quantifying the amount of aflatoxin adducted to human serum albumin. Aflatoxins 103-112 albumin Homo sapiens 131-144