PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2620379-1 1989 Poisoning with cholinesterase inhibiting insecticides such as organophosphates (OP) is a major health problem in Sri Lanka, with over 10,000 hospital admissions and over 1,000 hospital deaths annually. Organophosphates 62-78 butyrylcholinesterase Homo sapiens 15-29 2676871-9 1989 Phy carbamylates to a portion of ChE enzyme and thus protects the enzyme from binding with organophosphate, which are irreversible ChE inhibitors. Organophosphates 91-106 butyrylcholinesterase Homo sapiens 33-36 2682131-19 1989 Succinylcholine is hydrolysed by plasma cholinesterase, and drugs which decrease the activity of this enzyme may produce a prolonged block, i.e. contraceptive pills, cyclophosphamide, echothiopate and organophosphate. Organophosphates 201-216 butyrylcholinesterase Homo sapiens 40-54 2676871-9 1989 Phy carbamylates to a portion of ChE enzyme and thus protects the enzyme from binding with organophosphate, which are irreversible ChE inhibitors. Organophosphates 91-106 butyrylcholinesterase Homo sapiens 131-134 2731661-9 1989 Mean IC50"s for inhibition of CHE (a marker for occupational exposure to organophosphates and carbamates) by DFP, paraoxon, dichlorvos, carbofuran, and carbaryl were 1.0 X 10(-8), 4.1 X 10(-8), 1.0 X 10(-7), 3.3 X 10(-6), and 1.8 X 10(-5) M, respectively. Organophosphates 73-89 butyrylcholinesterase Homo sapiens 30-33 2746205-1 1989 A dot-blot immunoassay, using antiserum raised against esterase B1 responsible for organophosphate (OP) resistance in Culex quinquefasciatus, was used to study different laboratory strains and field collections of this species, as well as of Cx. Organophosphates 83-98 esterase B1 Culex quinquefasciatus 55-66 2917010-0 1989 Acetylcholinesterase prophylaxis against organophosphate poisoning. Organophosphates 41-56 acetylcholinesterase Mus musculus 0-20 2917010-2 1989 Fetal bovine serum acetylcholinesterase (FBS-AChE, EC 3.1.1.7) was titrated, both in vitro and in vivo, with a highly toxic anti-ChE organophosphate, 7-(methylethoxyphosphinyloxy)-1-methyl-quinolinium iodie (MEPQ). Organophosphates 133-148 acetylcholinesterase Mus musculus 19-39 2917010-2 1989 Fetal bovine serum acetylcholinesterase (FBS-AChE, EC 3.1.1.7) was titrated, both in vitro and in vivo, with a highly toxic anti-ChE organophosphate, 7-(methylethoxyphosphinyloxy)-1-methyl-quinolinium iodie (MEPQ). Organophosphates 133-148 acetylcholinesterase Mus musculus 45-49 2714216-1 1989 In vitro inhibition of goat cerebellar acetylcholinesterase by pure and commercial anticholinesterase pesticides clearly indicates a remarkably high inhibitory effect of commercial carbamate and organophosphate pesticides containing a lower percentage of the respective active ingredients comparable to that of the known anticholinesterase agents such as DFP and physostigmine. Organophosphates 195-210 acetylcholinesterase Capra hircus 39-59 2807406-3 1989 Based on I50 values the biphenyl derivatives of phosphoric acid esters were more potent anti acetylcholinesterase (AChE) agents against rat and fish brain AChE while derivative of carbamic esters towards pigeon brain AChE. Organophosphates 48-70 acetylcholinesterase Rattus norvegicus 93-113 2807406-3 1989 Based on I50 values the biphenyl derivatives of phosphoric acid esters were more potent anti acetylcholinesterase (AChE) agents against rat and fish brain AChE while derivative of carbamic esters towards pigeon brain AChE. Organophosphates 48-70 acetylcholinesterase Rattus norvegicus 115-119 2807406-3 1989 Based on I50 values the biphenyl derivatives of phosphoric acid esters were more potent anti acetylcholinesterase (AChE) agents against rat and fish brain AChE while derivative of carbamic esters towards pigeon brain AChE. Organophosphates 48-70 acetylcholinesterase Rattus norvegicus 155-159 2807406-3 1989 Based on I50 values the biphenyl derivatives of phosphoric acid esters were more potent anti acetylcholinesterase (AChE) agents against rat and fish brain AChE while derivative of carbamic esters towards pigeon brain AChE. Organophosphates 48-70 acetylcholinesterase Rattus norvegicus 155-159 2619560-1 1989 Organophosphate-induced delayed polyneuropathy (OPIDP) is initiated by inhibition/aging of more than 70-75% of neuropathy target esterase (NTE). Organophosphates 0-15 patatin like phospholipase domain containing 6 Gallus gallus 111-137 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Organophosphates 220-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Organophosphates 220-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 2729280-4 1989 Pesticides most frequently associated with cholinesterase depressions exceeding California threshold values included mevinphos (Phosdrin), oxydemeton methyl (Metasystox-R), methomyl (Lannate), and acephate (Orthene); these pesticides included organophosphates in toxicity categories I and II and one carbamate in toxicity category I. Organophosphates 243-259 butyrylcholinesterase Homo sapiens 43-57 2643783-1 1989 The authors investigated in human and in experimental organophosphate intoxication the features of the toxic ECG repolarisation disturbance, the QT lengthening and its connection with cholinesterase depression. Organophosphates 54-69 butyrylcholinesterase Homo sapiens 184-198 2619560-1 1989 Organophosphate-induced delayed polyneuropathy (OPIDP) is initiated by inhibition/aging of more than 70-75% of neuropathy target esterase (NTE). Organophosphates 0-15 patatin like phospholipase domain containing 6 Gallus gallus 139-142 2846530-3 1988 Bone acidic glycoprotein-75 is 75,000 in molecular weight with a 29.3% molar content of acidic amino acid residues, a 7.0% (w/w) content of sialic acid, and a 7.9% molar content of organic phosphate. Organophosphates 181-198 tyrosinase related protein 1 Homo sapiens 12-27 2709748-0 1989 [Circadian rhythm of blood acetylcholinesterase after administration of organophosphate compounds during hypokinesia]. Organophosphates 72-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 2920006-1 1989 Neuropathy target esterase (NTE) is a membrane-bound carboxylesterase activity that has been proposed as the target site for initiation of organophosphate-induced delayed neuropathy. Organophosphates 139-154 patatin like phospholipase domain containing 6 Gallus gallus 0-26 2920006-1 1989 Neuropathy target esterase (NTE) is a membrane-bound carboxylesterase activity that has been proposed as the target site for initiation of organophosphate-induced delayed neuropathy. Organophosphates 139-154 patatin like phospholipase domain containing 6 Gallus gallus 28-31 2622138-6 1989 This allows occupational physicians, who use cholinesterase measurements to monitor organo-phosphate exposure, to establish percentage depressions from their method precision data that may possibly indicate organo-phosphate uptake between successive enzyme measurements. Organophosphates 84-100 butyrylcholinesterase Homo sapiens 45-59 2622138-6 1989 This allows occupational physicians, who use cholinesterase measurements to monitor organo-phosphate exposure, to establish percentage depressions from their method precision data that may possibly indicate organo-phosphate uptake between successive enzyme measurements. Organophosphates 207-223 butyrylcholinesterase Homo sapiens 45-59 2474812-2 1989 In the present experiments, an organophosphate that only inhibits butyrylcholinesterase (isopropylpyrophosphoramide, or iso-OMPA) was compared with echothiophate and a nonorganophosphate compound, physostigmine. Organophosphates 31-46 butyrylcholinesterase Canis lupus familiaris 66-87 2459806-1 1988 Following single-pass perfusion of mouse livers in situ with the organophosphate pesticide chlorpyrifos, the cholinesterase inhibitor chlorpyrifos oxon could not be detected in effluent perfusate. Organophosphates 65-80 butyrylcholinesterase Mus musculus 109-123 3063684-3 1988 The regional effects of AChE inhibition by organophosphates was examined in a comparative study of the brains of two victims and two control brains, matched for age and sex. Organophosphates 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 3063684-6 1988 This specific distribution of AChE inhibition may be correlated with some of the clinical characteristics of acute organophosphate poisoning. Organophosphates 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 3418344-6 1988 It is proposed that: (1) The physiological turnover mechanism cannot distinguish between catalytically active and di-n-pentylphosphinylated NTE although initiation of organophosphate-induced delayed polyneuropathy might involve recognition of aged di-alkyl-phosphorylated NTE as "foreign". Organophosphates 167-182 patatin like phospholipase domain containing 6 Gallus gallus 272-275 3057326-4 1988 The mechanism of action of organophosphates has been determined in some depth; the understanding of the toxic effects resulting from the inhibition of cholinesterase activity, causing accumulation of acetylcholine at nerve endings has played a major part in providing a rationale for specific antidote treatment using atropine and oximes. Organophosphates 27-43 butyrylcholinesterase Homo sapiens 151-165 3394943-3 1988 At various times, phenyldichlorophosphate was added to the mixture of free and carbamylated enzyme, whereupon two very rapid, simultaneous reactions occurred: near total, and permanent, inactivation of free acetylcholinesterase by the organophosphate, and inactivation of phenyldichlorophosphate by hydrolysis. Organophosphates 235-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 3406954-1 1988 Phosphamidon, an organophosphate pesticide, is an established cholinesterase inhibitor. Organophosphates 17-32 butyrylcholinesterase Mus musculus 62-76 3350449-1 1988 Organophosphates are the most common group of chemicals involved in poisoning in Sri Lanka. Organophosphates 0-16 sorcin Homo sapiens 81-84 3351852-4 1988 The abilities of 1b-e to reactivate acetylcholinesterase (AChE) inhibited by organophosphates have been evaluated. Organophosphates 77-93 acetylcholinesterase Rattus norvegicus 58-62 2451511-7 1988 Evidence is presented for the existence of different species of high-density lipoprotein HDL2 particles containing different complements of peptide isoforms and expressing contrasting substrate specificities towards organophosphates. Organophosphates 216-232 junctophilin 3 Homo sapiens 89-93 3354230-2 1988 Both the cytochrome P-450-dependent mono-oxygenase system and the FAD-containing mono-oxygenase catalyse the sulphoxidation of thioether-containing organophosphate insecticides. Organophosphates 148-163 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 9-25 3341049-10 1988 These results indicate that prolonged inhibition of acetylcholinesterase caused by repeated organophosphate exposure alters spatial memory functions in rats, as well as causing a loss of muscarinic receptors. Organophosphates 92-107 acetylcholinesterase Rattus norvegicus 52-72 3672515-0 1987 Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance. Organophosphates 90-106 ACE-1 Oryctolagus cuniculus 61-81 3447642-0 1987 In vitro and in vivo effect of organophosphate pesticides on monoamine oxidase activity in rat brain. Organophosphates 31-46 monoamine oxidase A Rattus norvegicus 61-78 3447642-1 1987 The effects of some organophosphate pesticides, e.g. lebaycid, metacid and metasystox on the monoamine oxidase (MAO) activity in rat brain mitochondria have been studied. Organophosphates 20-35 monoamine oxidase A Rattus norvegicus 93-110 3447642-1 1987 The effects of some organophosphate pesticides, e.g. lebaycid, metacid and metasystox on the monoamine oxidase (MAO) activity in rat brain mitochondria have been studied. Organophosphates 20-35 monoamine oxidase A Rattus norvegicus 112-115 3672515-1 1987 The kinetics of the inhibition of eel and rabbit brain acetylcholinesterase by a number of organophosphates and carbamates has been studied. Organophosphates 91-107 ACE-1 Oryctolagus cuniculus 55-75 3629585-1 1987 Organophosphate-induced delayed polyneuropathy (OPIDP) is thought to result from organophosphorylation of neuropathy target esterase (NTE), followed by an "aging" of the phosphorylated NTE. Organophosphates 0-15 patatin like phospholipase domain containing 6 Homo sapiens 106-132 3653568-0 1987 Acetylcholinesterase prophylaxis against organophosphate toxicity. Organophosphates 41-56 acetylcholinesterase Mus musculus 0-20 3603322-2 1987 The type of poisoning which inhibits acetylcholinesterase (AChE) most often encountered in an intensive care unit is that of organophosphates (OP). Organophosphates 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 3603322-2 1987 The type of poisoning which inhibits acetylcholinesterase (AChE) most often encountered in an intensive care unit is that of organophosphates (OP). Organophosphates 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 3629585-1 1987 Organophosphate-induced delayed polyneuropathy (OPIDP) is thought to result from organophosphorylation of neuropathy target esterase (NTE), followed by an "aging" of the phosphorylated NTE. Organophosphates 0-15 patatin like phospholipase domain containing 6 Homo sapiens 134-137 3629585-1 1987 Organophosphate-induced delayed polyneuropathy (OPIDP) is thought to result from organophosphorylation of neuropathy target esterase (NTE), followed by an "aging" of the phosphorylated NTE. Organophosphates 0-15 patatin like phospholipase domain containing 6 Homo sapiens 185-188 3576947-1 1987 Cholinesterase (ChE) activity was measured in whole blood, plasma and certain tissues of goats experimentally poisoned with certain organophosphates, organochlorines, heavy metals and anthelmintic drugs. Organophosphates 132-148 CHE Capra hircus 16-19 3827420-6 1987 The data support the use of sequential postexposure plasma cholinesterase analyses to confirm the diagnosis of organophosphate-induced illness in the absence of baseline values. Organophosphates 111-126 butyrylcholinesterase Homo sapiens 59-73 3629272-0 1987 Serum pseudocholinesterase estimation in the management of organophosphate poisoning cases and the effect of PAM on regenerating it. Organophosphates 59-74 butyrylcholinesterase Homo sapiens 6-26 3827420-0 1987 Clinical confirmation of organophosphate poisoning by serial cholinesterase analyses. Organophosphates 25-40 butyrylcholinesterase Homo sapiens 61-75 3569845-7 1987 This method is applicable for the measuring of blood cholinesterase activities and thus monitoring humans exposed to organophosphates under field conditions. Organophosphates 117-133 butyrylcholinesterase Homo sapiens 53-67 3098245-2 1986 The present paper evaluates the interaction of aprophen with acetylcholinesterases, butyrylcholinesterases, and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition, accelerating pralidoxime iodide (2-PAM) regeneration of the diisopropylphospho-enzyme, and comparing the inhibition and regeneration kinetics of a soluble mammalian acetylcholinesterase with that of bovine erythrocyte acetylcholinesterase. Organophosphates 173-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 3561766-1 1987 The organophosphates, diisopropyl phosphorofluoridate and soman have a common mechanism of action (inhibition of acetylcholinesterase), but result in very different behavioral responses in the rat. Organophosphates 4-20 acetylcholinesterase Rattus norvegicus 113-133 3786359-7 1986 These data indicate that oral dosages of pyridostigmine can probably be titrated to levels of cholinesterase inhibition which are efficacious in prophylaxis against organophosphate toxicity without significant effects on selected physiologic and metabolic processes. Organophosphates 165-180 butyrylcholinesterase Rattus norvegicus 94-108 3551677-0 1986 Repeated asystole following PAM in organophosphate self-poisoning. Organophosphates 35-50 peptidylglycine alpha-amidating monooxygenase Homo sapiens 28-31 3775819-0 1986 Sequential cholinesterase tests and symptoms for monitoring organophosphate absorption in field workers and in persons exposed to pesticide spray drift. Organophosphates 60-75 butyrylcholinesterase Homo sapiens 11-25 2434058-0 1986 Inhibition of lymphocytic neuropathy target esterase predicts the development of organophosphate-induced delayed polyneuropathy. Organophosphates 81-96 patatin like phospholipase domain containing 6 Homo sapiens 26-52 3954784-7 1986 Reactivation by P2S of O-ethyl methylphosphonylated AChE prepared from (S) organophosphates proceeds with inversion of configuration at phosphorus. Organophosphates 71-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 3502583-2 1986 Plasma and red blood cell (RBC) cholinesterase activity level monitoring is used to detect early toxic effects of exposure to organophosphate and carbamate insecticides. Organophosphates 126-141 butyrylcholinesterase Homo sapiens 32-46 2432215-13 1986 The data presented in this report suggested that the new direct technique of assaying NTE activity using 4-nitrophenyl valerate (4-NPV) as substrate, can be useful in the in vivo screening studies of organophosphates for their ability to induce neuropathy in hens. Organophosphates 200-216 patatin like phospholipase domain containing 6 Gallus gallus 86-89 3741288-8 1986 HR (degree C X min-1) was the most sensitive index of drug activity with a 200 micrograms X kg-1 dose (equivalent to 2 mg in man for organophosphate poisoning) eliciting an increased HR from 0.022 degrees C (saline) to 0.087 degrees C X min-1 (atropine). Organophosphates 133-148 CD59 molecule (CD59 blood group) Homo sapiens 237-242 3015022-5 1986 The intact gene (opd, organophosphate-degrading gene) from this degradative plasmid was cloned into M13mp10 and found to express parathion hydrolase under control of the lac promoter in Escherichia coli. Organophosphates 22-37 opd Sphingobium fuliginis ATCC 27551 129-148 3788984-7 1986 These findings support the utility of sequential postexposure plasma cholinesterase analyses in confirmation of suspect organophosphate-induced illness when baseline values are not available. Organophosphates 120-135 butyrylcholinesterase Homo sapiens 69-83 3703907-4 1986 Cholinesterase activity was inhibited in a dose-dependent manner in brain and plasma after administration of the organophosphates and CTA was correlated with the degree of plasma cholinesterase inhibition. Organophosphates 113-129 butyrylcholinesterase Rattus norvegicus 0-14 3703907-4 1986 Cholinesterase activity was inhibited in a dose-dependent manner in brain and plasma after administration of the organophosphates and CTA was correlated with the degree of plasma cholinesterase inhibition. Organophosphates 113-129 butyrylcholinesterase Rattus norvegicus 179-193 3703907-5 1986 CTA appears to be a sensitive indicator of neurobehavioral effects of mild exposure to organophosphates which causes only 30-40% inhibition of plasma cholinesterase. Organophosphates 87-103 butyrylcholinesterase Rattus norvegicus 150-164 3028323-3 1986 The serum paraoxonase genotype has a significant influence on the paraoxon clearance and consequently on the toxic action of paraoxon and some related organophosphates and definitively protects the serum cholinesterase. Organophosphates 151-167 butyrylcholinesterase Homo sapiens 204-218 3512169-1 1986 The measurement of cholinesterase activity in human serum is an important investigation, especially in patients suspected of poisoning with organophosphate insecticides, or those experiencing prolonged paralysis following treatment with the short acting muscle relaxant succinylcholine. Organophosphates 140-155 butyrylcholinesterase Homo sapiens 19-33 4026382-1 1985 Measurement of neuropathy target esterase activity (NTE) in blood lymphocytes has been suggested as a possible biomonitor for organophosphate-induced delayed polyneuropathy. Organophosphates 126-141 patatin like phospholipase domain containing 6 Homo sapiens 15-41 2872135-10 1986 These results indicate that reduction of ACh release presynaptically plus neutralization of organophosphates with 2-PAM could be an effective way to reduce mortality in patients exposed to organophosphorus poisons. Organophosphates 92-108 peptidylglycine alpha-amidating monooxygenase Homo sapiens 116-119 3755763-5 1986 However, a consensus organophosphate-binding hexapeptide sequence Phe-Gly-Glu-Ser-Ala-Gly was found both in "true" acetylcholinesterase from the electric organ of Torpedo [McPhee-Quigley et al: J Biol Chem 260:12185-12189, 1985] and in "pseudocholinesterase" (butyrylcholinesterase) from human serum [Lockridge: "Cholinesterases--Fundamental and Applied Aspects." Organophosphates 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 3755763-5 1986 However, a consensus organophosphate-binding hexapeptide sequence Phe-Gly-Glu-Ser-Ala-Gly was found both in "true" acetylcholinesterase from the electric organ of Torpedo [McPhee-Quigley et al: J Biol Chem 260:12185-12189, 1985] and in "pseudocholinesterase" (butyrylcholinesterase) from human serum [Lockridge: "Cholinesterases--Fundamental and Applied Aspects." Organophosphates 21-36 butyrylcholinesterase Homo sapiens 237-282 3755763-10 1986 Furthermore, the sequence of this 12-amino acid peptide is identical to the sequence reported for the organophosphate binding site of human serum pseudocholinesterase [Lockridge: "Cholinesterases--Fundamental and Applied Aspects." Organophosphates 102-117 butyrylcholinesterase Homo sapiens 146-166 4092872-0 1985 Recovery of acetylcholinesterase activity after acute organophosphate treatment of CNS reaggregate cultures. Organophosphates 54-69 acetylcholinesterase Mus musculus 12-32 4065300-0 1985 Organophosphate-mediated inhibition of choline acetyltransferase activity in rat brain tissue. Organophosphates 0-15 choline O-acetyltransferase Rattus norvegicus 39-64 4065300-1 1985 Administration of the organophosphate compound soman in rats resulted in an inhibition of choline acetyltransferase activity in almost all brain regions examined. Organophosphates 22-37 choline O-acetyltransferase Rattus norvegicus 90-115 4059650-8 1985 Results indicate that prolonged exposure to low doses of organophosphate ChE inhibitors leads to necrosis of skeletal muscle fibers and may be observed without other overt signs of organophosphate toxicity. Organophosphates 57-72 butyrylcholinesterase Rattus norvegicus 73-76 4059650-8 1985 Results indicate that prolonged exposure to low doses of organophosphate ChE inhibitors leads to necrosis of skeletal muscle fibers and may be observed without other overt signs of organophosphate toxicity. Organophosphates 181-196 butyrylcholinesterase Rattus norvegicus 73-76 4059652-0 1985 Correlation of 2-PAM plasma levels after organophosphate intoxication. Organophosphates 41-56 peptidyl-glycine alpha-amidating monooxygenase Cavia porcellus 17-20 4092348-1 1985 Interest has recently been shown in the use of serum cholinesterase levels as a marker for chronic organophosphate insecticide exposure. Organophosphates 99-114 butyrylcholinesterase Homo sapiens 53-67 2417385-0 1985 Comparative sensitivity of bovine and rodent acetylcholinesterase to in vitro inhibition by organophosphate insecticides. Organophosphates 92-107 acetylcholinesterase Bos taurus 45-65 2417385-8 1985 The bimolecular reaction rate constants (ki) were also determined for inhibition of brain ACHE of cows and male rats by the three organophosphates. Organophosphates 130-146 acetylcholinesterase Bos taurus 90-94 2417385-11 1985 Both quantitative and qualitative differences between species and among the organophosphates were in excellent agreement with the results of the brain ACHE studies. Organophosphates 76-92 acetylcholinesterase Bos taurus 151-155 2417385-14 1985 In addition, the study demonstrated that, in general, ACHE from brain or erythrocytes of cows was less sensitive to in vitro inhibition by organophosphates than was that from male or female rats. Organophosphates 139-155 acetylcholinesterase Bos taurus 54-58 4026382-1 1985 Measurement of neuropathy target esterase activity (NTE) in blood lymphocytes has been suggested as a possible biomonitor for organophosphate-induced delayed polyneuropathy. Organophosphates 126-141 patatin like phospholipase domain containing 6 Homo sapiens 52-55 4026382-2 1985 Human lymphocyte NTE was characterized in vitro according to the sensitivity to several organophosphate inhibitors, which was found similar to that of the nervous system enzyme. Organophosphates 88-103 patatin like phospholipase domain containing 6 Homo sapiens 17-20 2466105-0 1985 Laboratory evaluation of four organophosphate compounds as larvicides against field collected salt marsh Culicoides spp. Organophosphates 30-45 histocompatibility minor 13 Homo sapiens 116-119 2466105-2 1985 The relative effectiveness of 4 organophosphate compounds was tested in the laboratory against Culicoides spp. Organophosphates 32-47 histocompatibility minor 13 Homo sapiens 106-109 3983971-1 1985 Health effects of occupational organophosphate exposure were investigated by subjecting 22 workers chronically exposed to an organophosphate pesticide, fenthion (O,O-dimethyl-O-(4-methylmercapto-3-methylphenyl)-phosphorothioate) to clinical evaluation, estimation of serum cholinesterase, serum alkaline phosphatase (SAP), serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). Organophosphates 31-46 amyloid P component, serum Homo sapiens 289-315 3983971-1 1985 Health effects of occupational organophosphate exposure were investigated by subjecting 22 workers chronically exposed to an organophosphate pesticide, fenthion (O,O-dimethyl-O-(4-methylmercapto-3-methylphenyl)-phosphorothioate) to clinical evaluation, estimation of serum cholinesterase, serum alkaline phosphatase (SAP), serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). Organophosphates 31-46 amyloid P component, serum Homo sapiens 317-320 6497906-1 1984 A comparative study of the reactivation by two oximes of acetylcholinesterase inhibited by several organophosphates has been made, with particular reference to the dependence of the degree of reactivation produced by an oxime (reactivating potency) upon the concentration of inhibited enzyme. Organophosphates 99-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 3881280-2 1985 Unlike radioimmunoassay, the new assay described herein can be extended to predict the feasibility of antibodies to confer in vivo protection of acetylcholinesterase against organophosphate poisoning. Organophosphates 174-189 acetylcholinesterase Mus musculus 145-165 3874715-1 1985 A programme emphasizing intensive training, use of protective equipment and uniforms, daily supervision of safety measures at work, and weekly monitoring of blood cholinesterase levels by the tintometric method was instituted to prevent toxicity in Haitian malaria workers during spraying with the organophosphate insecticides fenitrothion and malathion. Organophosphates 298-313 butyrylcholinesterase Homo sapiens 163-177 6497117-1 1984 Dogs exposed to topical organophosphate (fenthion) developed decreased plasma and muscle cholinesterase activities. Organophosphates 24-39 butyrylcholinesterase Canis lupus familiaris 89-103 6487368-8 1984 Furthermore we suggest that NTE inhibition should also be measured in the peripheral nerve in the standard toxicity testing for organophosphate-induced delayed neurotoxicity. Organophosphates 128-143 patatin like phospholipase domain containing 6 Gallus gallus 28-31 17422448-7 1984 Diagnosis of organophosphate poisoning was confirmed by tissue and feed analysis for terbufos and measurement of whole blood cholinesterase activity. Organophosphates 13-28 butyrylcholinesterase Bos taurus 125-139 6479498-9 1984 The results indicate that (a) the acute toxicity of organophosphate acetylcholinesterase inhibitors is directly related to the inhibition of AChE though there is a wide difference in their potency; (b) a substantial inhibition of AChE activity (over 90% of control) is necessary for lethality to ensue after an acute exposure and the margins between lethal and nonlethal doses are extremely small; and (c) qualitative differences seem to exist among the various organophosphates in affecting noncholinergic neurotransmitter enzymes. Organophosphates 462-478 acetylcholinesterase Rattus norvegicus 68-88 6493583-0 1984 Intra- versus extracellular recovery of 16S acetylcholinesterase following organophosphate inactivation in the rat. Organophosphates 75-90 acetylcholinesterase Rattus norvegicus 44-64 6478213-3 1984 This facilitation was similar to that previously observed in the same receptor type when acetylcholinesterase (AChE) was inhibited by various organophosphate or carbamate acetylcholinesterase inhibitors (AChEIs)3. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 6478213-3 1984 This facilitation was similar to that previously observed in the same receptor type when acetylcholinesterase (AChE) was inhibited by various organophosphate or carbamate acetylcholinesterase inhibitors (AChEIs)3. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 6479498-9 1984 The results indicate that (a) the acute toxicity of organophosphate acetylcholinesterase inhibitors is directly related to the inhibition of AChE though there is a wide difference in their potency; (b) a substantial inhibition of AChE activity (over 90% of control) is necessary for lethality to ensue after an acute exposure and the margins between lethal and nonlethal doses are extremely small; and (c) qualitative differences seem to exist among the various organophosphates in affecting noncholinergic neurotransmitter enzymes. Organophosphates 462-478 acetylcholinesterase Rattus norvegicus 141-145 6479498-9 1984 The results indicate that (a) the acute toxicity of organophosphate acetylcholinesterase inhibitors is directly related to the inhibition of AChE though there is a wide difference in their potency; (b) a substantial inhibition of AChE activity (over 90% of control) is necessary for lethality to ensue after an acute exposure and the margins between lethal and nonlethal doses are extremely small; and (c) qualitative differences seem to exist among the various organophosphates in affecting noncholinergic neurotransmitter enzymes. Organophosphates 462-478 acetylcholinesterase Rattus norvegicus 230-234 6737998-1 1984 A simple and reliable method based on cholinesterase inhibition is proposed to detect organophosphate pesticides in water. Organophosphates 86-101 butyrylcholinesterase Homo sapiens 38-52 6599819-0 1984 Some possibilities of protection against acetylcholinesterase inhibition by organophosphates in vivo. Organophosphates 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. Organophosphates 293-309 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6520887-6 1984 The study was continued because NTE inhibition has been shown to be a reliable predictor of organophosphates that produce delayed neurotoxicity. Organophosphates 92-108 patatin like phospholipase domain containing 6 Gallus gallus 32-35 6708739-9 1984 It is suggested that the organophosphate-induced analgesia is due to a combination of an increased concentration of acetylcholine due to inhibition of acetylcholinesterase combined with a reduced destruction of endogenous opioid-like substances due to organophosphate inhibition of proteases. Organophosphates 25-40 acetylcholinesterase Mus musculus 151-171 6534735-6 1984 The results indicate organophosphate-induced PI can be attenuated by pretreatment with tertiary carbamates which protect significant amounts of brain AChE from irreversible inhibition. Organophosphates 21-36 acetylcholinesterase Rattus norvegicus 150-154 6147281-0 1984 Relationship between serum lipids, lipoproteins and pseudocholinesterase during organophosphate poisoning in rabbits. Organophosphates 80-95 cholinesterase Oryctolagus cuniculus 52-72 6623467-4 1983 Birds from the low social stress group moved 24 hr prior to TOTP were more susceptible to inhibition of brain and liver cholinesterase activities following organophosphate administration. Organophosphates 156-171 butyrylcholinesterase Gallus gallus 120-134 6662290-5 1983 Because of the rapid and slowly reversible inhibition of acetylcholinesterase by organophosphate insecticides, hemoperfusion alone will not improve the clinical status of organophosphate insecticide poisoned patients. Organophosphates 81-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6640161-0 1983 Structure-activity relationship in organophosphate-induced beta-glucuronidase release from rat hepatocytes in vitro. Organophosphates 35-50 glucuronidase, beta Rattus norvegicus 59-77 6193335-3 1983 Chlorpyrifos concentrations and tissue cholinesterase and in esterase inhibitions indicated the presence of the organophosphate and its biochemical effect, but few cholinergic signs were observed clinically. Organophosphates 112-127 butyrylcholinesterase Homo sapiens 39-53 6624479-0 1983 Organophosphate metasystox-induced increment of lipase activity and lipid peroxidation in cerebral hemisphere: diminution of lipids in discrete areas of the rat brain. Organophosphates 0-15 lipase G, endothelial type Rattus norvegicus 48-54 6664408-5 1983 In the case of organophosphate and carbamate derivatives the determination of cholinesterase activity proved to be less sensitive than the neurotoxicological measurements as an index of toxicity. Organophosphates 15-30 butyrylcholinesterase Homo sapiens 78-92 6870912-2 1983 The protective action is shown to depend on the provision (by carbamylation) of a pool of sequestered cholinesterase resistant to organophosphates but which furnishes (by decarbamylation) sufficient active enzyme to essential cholinergic synapses to ensure survival until all free organophosphate is cleared from the tissues. Organophosphates 130-146 butyrylcholinesterase Homo sapiens 102-116 6870912-2 1983 The protective action is shown to depend on the provision (by carbamylation) of a pool of sequestered cholinesterase resistant to organophosphates but which furnishes (by decarbamylation) sufficient active enzyme to essential cholinergic synapses to ensure survival until all free organophosphate is cleared from the tissues. Organophosphates 130-145 butyrylcholinesterase Homo sapiens 102-116 6821947-10 1983 Thus erythrocyte cholinesterase measurements can readily be made, to complement plasma cholinesterase in the investigation of exposure to organophosphates. Organophosphates 138-154 butyrylcholinesterase Homo sapiens 17-31 6835011-3 1983 An effect of NaF on organophosphate inhibited acetylcholinesterase could not account for the antidotal action of NaF. Organophosphates 20-35 acetylcholinesterase Mus musculus 46-66 6298988-0 1983 Organophosphate poisoning: modifications in acid base equilibrium and use of sodium bicarbonate as an aid in the treatment of toxicity in dogs. Organophosphates 0-15 activation induced cytidine deaminase Canis lupus familiaris 102-105 6827532-0 1983 In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide. Organophosphates 64-79 acetylcholinesterase Mus musculus 35-55 7153825-4 1982 A 21-month-old white girl swallowed Dermaton, an organophosphate pesticide, and developed primary position upbeat nystagmus, RBC and plasma cholinesterase levels were markedly depressed, confirming organophosphate poisoning. Organophosphates 198-213 butyrylcholinesterase Homo sapiens 140-154 6662350-2 1983 The cholinesterase inhibiting action of the organophosphates (OPs) is better compensated by vitamin E in normal animals, but by vitamin A in vitamin A-deficient animals. Organophosphates 44-60 butyrylcholinesterase Rattus norvegicus 4-18 6617950-4 1983 Organophosphate inhibition data of primate acetylcholinesterase (EC 3.1.1.7) and of primate cholinesterase (EC 3.1.1.8) were determined and are compared to corresponding data of primate brain carboxylesterases. Organophosphates 0-15 butyrylcholinesterase Macaca mulatta 49-63 7121200-1 1982 In vitro studies showed that organophosphate insecticides have different IC50 values (i.e., concentration of inhibitor required to inhibit 50% enzyme activity) for acetylcholinesterases (AChE"s) from different species. Organophosphates 29-44 acetylcholinesterase (Cartwright blood group) Gallus gallus 187-191 7173436-1 1982 The effects of reversible (galanthamine, eserine) and irreversible organophosphate (armine) cholinesterase inhibitors on excitable muscle fibre membrane of the frog involved elongation of the rise and the half-decay time of the AP (galanthamine and eserine), the critical level of depolarization being shifted to a more negative value. Organophosphates 67-82 butyrylcholinesterase Homo sapiens 92-106 7181102-0 1982 Identification of isoenzymes in cholinesterase preparations using kinetic data of organophosphate inhibition. Organophosphates 82-97 butyrylcholinesterase Homo sapiens 32-46 7109004-0 1982 Treatment of acute organophosphate poisoning: evidence of a direct effect on central nervous system by 2-PAM (pyridine-2-aldoxime methyl chloride). Organophosphates 19-34 peptidylglycine alpha-amidating monooxygenase Homo sapiens 105-108 7029339-2 1981 injection of 1.82 mg/kg of the irreversible cholinesterase inhibitor organophosphate, diisopropylfluorophosphate (DFP). Organophosphates 69-84 butyrylcholinesterase Rattus norvegicus 44-58 6178187-1 1982 The organophosphate insecticide, leptophos, inhibited rat liver isocarboxazid amidase (ISOCase) activity to 20% of control at 5.0 mg/kg l h after administration, but at this dose brain cholinesterase (ChE) activity was not affected. Organophosphates 4-19 butyrylcholinesterase Rattus norvegicus 201-204 7314702-0 1981 [Inhibition of cholinesterase activity in human blood plasma by organophosphate insecticides and their metabolites using the delta-pH method]. Organophosphates 64-79 butyrylcholinesterase Homo sapiens 15-29 7077681-11 1982 These results suggest that the differences between chickens and mice in susceptibility to neurotoxic organophosphates may be attributed to (1) inhibitor specificity of NTE forms in the brain in these two different animal species and/or (2) inability of the active metabolites of these neurotoxic compounds to reach the site of action. Organophosphates 101-117 patatin-like phospholipase domain containing 6 Mus musculus 168-171 6297513-8 1982 The effective detoxication time (teff) was determined for different concentrations of paraoxon and DFP and was compared with the time needed by these organophosphate concentrations to inhibit AChE-activity to 12.5% of normal (t1/8). Organophosphates 150-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 7083404-0 1982 Effect of organophosphate pesticides on the activities of lecithin-cholesterol acyltransferase and cholinesterase in rat serum. Organophosphates 10-25 lecithin-cholesterol acyltransferase Homo sapiens 58-94 7083404-0 1982 Effect of organophosphate pesticides on the activities of lecithin-cholesterol acyltransferase and cholinesterase in rat serum. Organophosphates 10-25 butyrylcholinesterase Homo sapiens 99-113 7338956-1 1981 Delayed neurotoxicity after acute administration of organophosphates to hens can be predicted by using the neurotoxic esterase (NTE) assay. Organophosphates 52-68 patatin like phospholipase domain containing 6 Gallus gallus 107-126 7338956-1 1981 Delayed neurotoxicity after acute administration of organophosphates to hens can be predicted by using the neurotoxic esterase (NTE) assay. Organophosphates 52-68 patatin like phospholipase domain containing 6 Gallus gallus 128-131 7294467-6 1981 Cattle and sheep poisoned with organophosphate or carbamate insecticides had cholinesterase depression ranging from near 50% to 80%. Organophosphates 31-46 cholinesterase Ovis aries 77-91 7184786-1 1981 It has been shown that some reversible cholinesterase (ChE) inhibitors as physostigmine and pyridostigmine are prophylactically effective in organophosphate poisoning. Organophosphates 141-156 butyrylcholinesterase Mus musculus 39-53 7237968-0 1981 Correlation of serum pseudocholinesterase and clinical course in two patients poisoned with organophosphate insecticides. Organophosphates 92-107 butyrylcholinesterase Homo sapiens 21-41 7184786-1 1981 It has been shown that some reversible cholinesterase (ChE) inhibitors as physostigmine and pyridostigmine are prophylactically effective in organophosphate poisoning. Organophosphates 141-156 butyrylcholinesterase Mus musculus 55-58 7265327-0 1981 Increase of beta-glucuronidase activity in the serum of rats administered organophosphate and carbamate insecticides. Organophosphates 74-89 glucuronidase, beta Rattus norvegicus 12-30 7256362-0 1981 Serum and red cell cholinesterase activity in people exposed to organophosphate insecticides. Organophosphates 64-79 butyrylcholinesterase Homo sapiens 19-33 7256362-9 1981 Findings of low serum cholinesterase with normal red cell cholinesterase levels without signs or symptoms of toxicity indicated that these workers had been exposed to some degree of organophosphate insecticides. Organophosphates 182-197 butyrylcholinesterase Homo sapiens 22-36 7265327-1 1981 An approximately 50-fold increase in serum beta-glucuronidase activity appeared 2 hours after the administration of such organophosphate insecticides as dichlorvs, diazinon and disulfoton and of a carbamate insecticide, carbaryl. Organophosphates 121-136 glucuronidase, beta Rattus norvegicus 43-61 7227229-7 1981 The results are consistent with the ideas that the distribution of AChE molecular forms is regulated during embryonic development and that AChE is first synthesized as a low molecular weight form following inhibition with organophosphate compounds. Organophosphates 222-237 acetylcholinesterase (Cartwright blood group) Gallus gallus 139-143 7224673-6 1981 Recovery of brain ChE activity can be modeled for interpretation of sublethal inhibition of brain ChE activities in wild birds following environmental applications of organophosphates. Organophosphates 167-183 LOW QUALITY PROTEIN: cholinesterase Anas platyrhynchos 18-21 7224673-6 1981 Recovery of brain ChE activity can be modeled for interpretation of sublethal inhibition of brain ChE activities in wild birds following environmental applications of organophosphates. Organophosphates 167-183 LOW QUALITY PROTEIN: cholinesterase Anas platyrhynchos 98-101 497002-0 1979 Some adjuncts to oxime-atropine therapy for organophosphate intoxication--their effects on acetylcholinesterase. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 7234437-0 1980 Acetylcholinesterase activity in several rat liver cell fractions after repeated poisoning with some organophosphates. Organophosphates 101-117 acetylcholinesterase Rattus norvegicus 0-20 7376900-0 1980 Protective effect of some pyridinium salts on acetylcholinesterase against organophosphate inhibition. Organophosphates 75-90 acetylcholinesterase Mus musculus 46-66 20487783-2 1980 The relationship of this theory to the inhibition of acetylcholinesterase by organophosphates is emphasized. Organophosphates 77-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 7281197-0 1981 Continual monitoring of the reactivation effect of oximes on blood acetylcholinesterase in the rats poisoned with organophosphates. Organophosphates 114-130 acetylcholinesterase Rattus norvegicus 67-87 7440921-0 1980 Organophosphate pesticide inhibition of cholinesterase in laboratory animals and man and effects of oxime reactivators. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 40-54 7266492-0 1980 [Value of serum cholinesterase activity in the postmortem diagnosis of phosphoric acid ester poisoning]. Organophosphates 71-92 butyrylcholinesterase Homo sapiens 16-30 7376206-0 1980 Delayed neurotoxicity caused by chronic feeding of organophosphates requires a high-point of inhibition of neurotoxic esterase. Organophosphates 51-67 patatin like phospholipase domain containing 6 Gallus gallus 107-126 428776-0 1979 [Activity of cholinesterase and its isoenzymes in the blood of persons in contact with organophosphate pesticides]. Organophosphates 87-102 butyrylcholinesterase Homo sapiens 13-27 568924-0 1978 Binding of the organophosphates parathion and paraoxon to bovine and human serum albumin. Organophosphates 15-31 albumin Bos taurus 75-88 34396-0 1979 Enzymatic methemoglobin reduction - effect of organic phosphate. Organophosphates 46-63 hemoglobin subunit gamma 2 Homo sapiens 10-23 446594-1 1979 DDVP is an organophosphate pesticide whose neurotoxicity, in the form of cholinesterase inhbition, is well-known. Organophosphates 11-26 butyrylcholinesterase Rattus norvegicus 73-87 568924-4 1978 The organophosphates interact with only one type of binding sites in BSA and HSA. Organophosphates 4-20 albumin Bos taurus 69-72 24717-0 1978 Cyclic GMP concentrations in cerebellum following organophosphate administration. Organophosphates 50-65 5'-nucleotidase, cytosolic II Homo sapiens 7-10 686974-2 1978 The increased duration of action of succinylcholine resulted from low levels of serum cholinesterase that had been caused by the organophosphate. Organophosphates 129-144 butyrylcholinesterase Homo sapiens 86-100 677965-0 1978 Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication. Organophosphates 79-94 peptidylglycine alpha-amidating monooxygenase Homo sapiens 71-74 74508-3 1978 In field studies low red-cell cholinesterase activities were associated with the signs and symptoms of organophosphate insecticide intoxication. Organophosphates 103-118 butyrylcholinesterase Homo sapiens 30-44 618734-7 1978 These findings suggest that some esterase having an anionic site and an esteratic site, probably cholinesterase, may mediate in the uterine contractions induced by acetate esters in the presence of choline, and that inhibition by organophosphates, carbamates and quaternary ammonium compounds of cholinesterase activity in the preparation may impede the initiation of contractions by the acetate esters in the presence of choline. Organophosphates 230-246 butyrylcholinesterase Rattus norvegicus 97-111 618734-7 1978 These findings suggest that some esterase having an anionic site and an esteratic site, probably cholinesterase, may mediate in the uterine contractions induced by acetate esters in the presence of choline, and that inhibition by organophosphates, carbamates and quaternary ammonium compounds of cholinesterase activity in the preparation may impede the initiation of contractions by the acetate esters in the presence of choline. Organophosphates 230-246 butyrylcholinesterase Rattus norvegicus 296-310 577680-0 1977 Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential. Organophosphates 52-68 patatin like phospholipase domain containing 6 Gallus gallus 18-37 28563704-2 1977 SELECTION FOR THE AMOUNT OF ACETYLCHOLINESTERASE AFTER ORGANOPHOSPHATE TREATMENT. Organophosphates 55-70 acetylcholinesterase Bactrocera oleae 28-48 589706-0 1977 Comparison of inhibitory actions of organophosphate pesticides on cholinesterase and lecithin-cholesterol acyltransferase in human plasma. Organophosphates 36-51 butyrylcholinesterase Homo sapiens 66-80 589706-0 1977 Comparison of inhibitory actions of organophosphate pesticides on cholinesterase and lecithin-cholesterol acyltransferase in human plasma. Organophosphates 36-51 lecithin-cholesterol acyltransferase Homo sapiens 85-121 930782-0 1977 [Electroretinographic (ERG) study in toxic myopia due to organophosphate pesticides--therapeutic trial by 2-PAM (author"s transl)]. Organophosphates 57-72 ETS transcription factor ERG Homo sapiens 23-26 577680-1 1977 The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. Organophosphates 106-121 patatin like phospholipase domain containing 6 Gallus gallus 13-32 577680-1 1977 The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. Organophosphates 106-121 patatin like phospholipase domain containing 6 Gallus gallus 34-37 906734-0 1977 Continual determination of acetylcholinesterase inhibition following organophosphate poisoning using an auto analyzer. Organophosphates 69-84 acetylcholinesterase Rattus norvegicus 27-47 857397-4 1977 Experimental doses of 1/2-1 gm/kg body weight of these organophosphate compounds caused depression of cholinesterase and axonal degeneration in the spinal cord. Organophosphates 55-70 butyrylcholinesterase Bos taurus 102-116 990993-1 1976 The reversible binding constant (Ki) for tetramethylammonium ion (TMA) was determined from the decrease in the bimolecular rate constant (ki) observed with each of 21 organophosphate or carbamate inhibitors of acetylcholinesterase (EC 3.1.1.7). Organophosphates 167-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 755661-0 1977 In vivo inhibition of rabbit whole blood cholinesterase with organophosphate inhibitors and reactivation with oximes. Organophosphates 61-76 cholinesterase Oryctolagus cuniculus 41-55 566492-0 1977 [Histochemical behavior of acetylcholinesterase in the diaphragm and that of unspecific esterase in the hypothalamus, testes and liver of rats in relation to organophosphates]. Organophosphates 158-174 acetylcholinesterase Rattus norvegicus 27-47 1004139-0 1976 Organophosphate toxicity: kinetic differences between acetylcholinesterase of the housefly thorax and head? Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 10958-5 1976 On the other hand, the lowering of intracellular pH by organic phosphates accumulated in the cells was much larger with PLP than with 2,3-DPG. Organophosphates 55-73 pyridoxal phosphatase Homo sapiens 120-123 1259965-3 1976 Nonspecific lipase is seen to be very sensitive to inhibition by organophosphates but resistant to quinine. Organophosphates 65-81 lipase G, endothelial type Rattus norvegicus 12-18 1166305-3 1975 As a result of this approach, the brain cholinesterase blocked by organophosphates could be reactivated. Organophosphates 66-82 butyrylcholinesterase Homo sapiens 40-54 782776-2 1976 Clinical reports and laboratory investigations have generally supported the assumption that neurobehavioral manifestations of organophosphate toxicity are attributable to accumulation of acetylcholine at central and peripheral synapses as a result of cholinesterase inhibition. Organophosphates 126-141 butyrylcholinesterase Homo sapiens 251-265 242260-0 1975 Different forms of rat beta-glucuronidase with rapid and slow clearance following intravenous injection: selective serum enhancement of slow clearance forms by organophosphate compounds. Organophosphates 160-175 glucuronidase, beta Rattus norvegicus 23-41 236606-0 1975 Cholinesterase inhibition by phenothiazine and nonphenothiazine antihistaminics: analysis of its postulated role in synergizing organophosphate toxicity. Organophosphates 128-143 butyrylcholinesterase Homo sapiens 0-14 1188955-1 1975 This study revealed the influence of organophosphate pesticides on cholinesterase levels of male Sprague-Dawley rats. Organophosphates 37-52 butyrylcholinesterase Rattus norvegicus 67-81 1213034-4 1975 Visible symptoms of organophosphate poisoning were apparent only after the AChE inhibition reached 80%. Organophosphates 20-35 acetylcholinesterase Fundulus heteroclitus 75-79 1190970-0 1975 [Phosphoric acid ester preparations used in cattle, swine and sheep with special reference to cholinesterase activity. Organophosphates 1-22 cholinesterase Ovis aries 94-108 1190970-2 1975 Use of phosphoric acid ester preparations and their effect on acetylcholinesterase activity in swine]. Organophosphates 7-28 acetylcholinesterase (Yt blood group) Sus scrofa 62-82 1190971-0 1975 [Phosphoric acid ester preparations used in cattle, swine and sheep with special reference to cholinesterase activity. Organophosphates 1-22 cholinesterase Ovis aries 94-108 1164781-0 1975 Effect of organophosphate pesticide on acid cholesterol esterase in rat liver. Organophosphates 10-25 carboxyl ester lipase Rattus norvegicus 44-64 1230907-0 1975 [EEG in intoxication by cholinesterase inhibitors (organo-phosphate insecticides)]. Organophosphates 51-67 butyrylcholinesterase Homo sapiens 24-38 1213562-0 1975 [Our experiences in determination of the serum cholinesterase activity in workers occupationally exposed to organophosphate insecticides]. Organophosphates 108-123 butyrylcholinesterase Homo sapiens 47-61 4847537-0 1974 Effect of organophosphate pesticides on lecithin-cholesterol acyltransferase in human plasma. Organophosphates 10-25 lecithin-cholesterol acyltransferase Homo sapiens 40-76 4737014-0 1973 Recording spectrophotometric method for determination of dissociation and phosphorylation constants for the inhibition of acetylcholinesterase by organophosphates in the presence of substrate. Organophosphates 146-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 4677141-7 1972 The second-order rate constants (k(a)) for inhibition of human serum cholinesterase by one organophosphate and one carbamate increased from 5 degrees to 40 degrees C with an apparent activation energy of 46kJ/mol (11kcal/mol). Organophosphates 91-106 butyrylcholinesterase Homo sapiens 69-83 4776859-0 1973 [Blood cholinesterase activity in workers exposed to the organophosphate insecticide Ekatin]. Organophosphates 57-72 butyrylcholinesterase Homo sapiens 7-21 5002755-0 1971 Affinity of human brain acetylcholinesterase to some organophosphates and carbamates in vitro. Organophosphates 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 5527564-0 1970 Localization of aliesterase and acetylcholinesterase enzymes in various tissues of susceptible and organophosphate resistant Musca domestica L. Organophosphates 99-114 neuroligin-4, Y-linked Musca domestica 32-52 5763427-0 1969 Kinetics of cholinesterase inhibition by organophosphate and carbamate insecticides. Organophosphates 41-56 butyrylcholinesterase Homo sapiens 12-26 4319205-0 1970 [Studies of the relationship between the degree of acetylcholinesterase inhibition by organophosphates and the decrease in tetanic responses in a phrenic nerve-diaphragm preparation of the rat]. Organophosphates 86-102 acetylcholinesterase Rattus norvegicus 51-71 5388045-0 1969 [Reactivation of cholinesterase inhibited by organophosphates. Organophosphates 45-61 butyrylcholinesterase Homo sapiens 17-31 5773454-0 1969 Action of organophosphates on pancreatic lipase. Organophosphates 10-26 pancreatic lipase Homo sapiens 30-47 4951699-1 1967 Whole blood cholinesterase inhibition in vitro by an organic phosphate antihelminthic. Organophosphates 53-70 butyrylcholinesterase Homo sapiens 12-26 5249942-0 1967 [Synthesis, toxicity and cholinesterase inhibitory effect of N-methyl-pyridinium-2-aldoxime salts of phosphoric acid esters insecticides]. Organophosphates 101-123 butyrylcholinesterase Homo sapiens 25-39 4308685-0 1966 Recovery of cholinesterase activity in organophosphate treated insects. Organophosphates 39-54 butyrylcholinesterase Homo sapiens 12-26 5633615-0 1967 [The modification of cholinesterase and acetylcholinesterase by a phosphoric acid ester compound Tiguvon (Bayer) in mice experimentally infected with trichinae]. Organophosphates 66-87 butyrylcholinesterase Mus musculus 21-35 5633615-0 1967 [The modification of cholinesterase and acetylcholinesterase by a phosphoric acid ester compound Tiguvon (Bayer) in mice experimentally infected with trichinae]. Organophosphates 66-87 acetylcholinesterase Mus musculus 40-60 5969209-0 1966 The in vivo protection by gamma-aminobutyric acid against organic phosphate inhibition of AChE. Organophosphates 58-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 16742429-2 1966 The K(m) and catalytic-centre activities for human serum cholinesterase and methyl, ethyl, n-propyl and n-butyl butyrate substrates were determined and compared with the related inhibition constants of a similarly substituted organophosphate inhibitor series based on malaoxon. Organophosphates 226-241 butyrylcholinesterase Homo sapiens 57-71 17121390-3 1966 Previous work has shown the percentage of organophosphate-sensitive sites in these cells which can be taken as active centers of acetylcholinesterase (AChase). Organophosphates 42-57 acetylcholinesterase Rattus norvegicus 129-149 5892949-0 1965 Changes in the radioactivity of P-32-labelled acid-soluble organophosphates in blood platelets during collagen-and adenosine diphosphate-induced platelet aggregation. Organophosphates 59-75 inhibitor of growth family member 2 Homo sapiens 32-36 17121390-3 1966 Previous work has shown the percentage of organophosphate-sensitive sites in these cells which can be taken as active centers of acetylcholinesterase (AChase). Organophosphates 42-57 acetylcholinesterase Rattus norvegicus 151-157 5880969-0 1965 [Determination of the lymph node dose of radioactivity after the intralymphatic infusion of P32 administered as a lipid-soluble phosphoric ester (tri-n-octyl ester of phosphoric acid P32)]. Organophosphates 128-144 inhibitor of growth family member 2 Homo sapiens 92-95 5880969-0 1965 [Determination of the lymph node dose of radioactivity after the intralymphatic infusion of P32 administered as a lipid-soluble phosphoric ester (tri-n-octyl ester of phosphoric acid P32)]. Organophosphates 128-144 inhibitor of growth family member 2 Homo sapiens 183-186 5938096-0 1966 Cholinesterase activities of various nematode parasites and their inhibition by the organophosphate anthelmintic haloxon. Organophosphates 84-99 butyrylcholinesterase Homo sapiens 0-14 14077543-0 1964 CHOLINESTERASE INHIBITION IN SPIDER MITES SUSCEPTIBLE AND RESISTANT TO ORGANOPHOSPHATE. Organophosphates 71-86 butyrylcholinesterase Homo sapiens 0-14 14077543-1 1964 Evidence is provided that organophosphate resistance in a strain of spider mites is due to decreased sensitivity of its cholinesterase to organophosphates. Organophosphates 26-41 butyrylcholinesterase Homo sapiens 120-134 14223684-1 1964 THE DISCHLORIDE OF BIS-(4-HYDROXYIMINOMETHYL-1-PYRIDINIUM-METHYL)-ETHER (LUEH6), A NEW REACTIVATOR OF ACETYLCHOLINESTERASE INHIBITED BY ORGANIC PHOSPHORIC ACID ESTERS]. Organophosphates 144-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 14077543-1 1964 Evidence is provided that organophosphate resistance in a strain of spider mites is due to decreased sensitivity of its cholinesterase to organophosphates. Organophosphates 138-154 butyrylcholinesterase Homo sapiens 120-134 13304690-4 1956 Organic phosphates destroy cholinesterase and produce effects related to overstimulation of the cholinergic branch of the autonomic nervous system. Organophosphates 0-18 butyrylcholinesterase Homo sapiens 27-41 14222625-0 1964 [STUDY OF THE COMBINATION OF PHOSPHORIC ESTERS WITH HUMAN SERUM ALBUMIN]. Organophosphates 29-46 albumin Homo sapiens 64-72 14182639-0 1964 [ON SOME CASES OF ACUTE INTOXICATION BY PHOSPHORIC ESTERS TREATED WITH OXIMES (RP 7676 AND PAM)]. Organophosphates 40-57 peptidylglycine alpha-amidating monooxygenase Homo sapiens 92-95 13824284-0 1959 [Therapeutic effects in man of combined ACTH, chlorpromazine and atropine treatment in poisoning by phosphoric esters]. Organophosphates 100-117 proopiomelanocortin Homo sapiens 40-44 13269715-0 1955 Effect of nicotinhydroxamic acid methiodide on human plasma cholinesterase inhibited by organophosphates containing a dialkylphosphato group. Organophosphates 88-104 butyrylcholinesterase Homo sapiens 60-74 13348109-0 1956 [Splitting of phosphoric esters of Str. Organophosphates 14-31 statherin Homo sapiens 35-38 13319312-0 1956 Protection of cholinesterase by ethanol against inhibition by organophosphates in vitro. Organophosphates 62-78 butyrylcholinesterase Homo sapiens 14-28 33934188-0 2021 Ensemble machine learning to evaluate the in vivo acute oral toxicity and in vitro human acetylcholinesterase inhibitory activity of organophosphates. Organophosphates 133-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 34019427-1 2021 Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 34019427-1 2021 Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 33990679-2 2021 Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs. Organophosphates 22-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 33990679-2 2021 Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs. Organophosphates 22-37 butyrylcholinesterase Homo sapiens 85-106 33990679-2 2021 Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs. Organophosphates 22-37 butyrylcholinesterase Homo sapiens 108-112 34045954-4 2021 Liver X receptor alpha (LXRalpha) is an autoregulatory transcription factor for ABCA1 and a target of some environmental pollutants, such as organophosphate pesticides. Organophosphates 141-156 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 33914192-1 2021 The non-target toxicity and resistance problems of acetylcholinesterase (AChE) insecticides, such as organophosphates and carbamates, are of growing concern. Organophosphates 101-117 acetylcholinesterase-like Tetranychus urticae 51-71 33529768-1 2021 Organophosphate pesticides and nerve agents (OPs), are characterized by cholinesterase inhibition. Organophosphates 0-15 butyrylcholinesterase Mus musculus 72-86 33914192-1 2021 The non-target toxicity and resistance problems of acetylcholinesterase (AChE) insecticides, such as organophosphates and carbamates, are of growing concern. Organophosphates 101-117 acetylcholinesterase-like Tetranychus urticae 73-77 33529769-6 2021 Butyrylcholinesterase (BChE), for example, provides prophylactic protection against organophosphate nerve agents (OPNAs), yet the short circulation life of the drug requires extraordinary doses. Organophosphates 84-99 butyrylcholinesterase Homo sapiens 0-21 33900070-1 2021 Chlorpyrifos (CPF) is an organophosphate (OP) pesticide that causes acute toxicity by inhibiting acetylcholinesterase (AChE) in the nervous system. Organophosphates 25-40 acetylcholinesterase Mus musculus 97-117 33900070-1 2021 Chlorpyrifos (CPF) is an organophosphate (OP) pesticide that causes acute toxicity by inhibiting acetylcholinesterase (AChE) in the nervous system. Organophosphates 25-40 acetylcholinesterase Mus musculus 119-123 33920972-6 2021 Cholinesterase interactions with both narcotics and organophosphate compounds are discussed, with the latter focusing primarily on molecular recognition studies of potential therapeutic value and on improving our understanding of the reactivation of cholinesterases that are bound to toxins. Organophosphates 52-67 butyrylcholinesterase Homo sapiens 0-14 33916863-0 2021 A Fluidics-Based Biosensor to Detect and Characterize Inhibition Patterns of Organophosphate to Acetylcholinesterase in Food Materials. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 33529769-6 2021 Butyrylcholinesterase (BChE), for example, provides prophylactic protection against organophosphate nerve agents (OPNAs), yet the short circulation life of the drug requires extraordinary doses. Organophosphates 84-99 butyrylcholinesterase Homo sapiens 23-27 33512614-1 2021 OBJECTIVE: To develop a convenient and efficient means for organophosphate (OP) insecticide detection, a simple, cost-effective, and easy-to-use absorbance-based sensing device was generated using methyl parathion hydrolase fused with glutathione-S-transferase (MPH-GST) covalently immobilized onto a chitosan film-coated microplate. Organophosphates 59-74 glutathione S-transferase kappa 1 Homo sapiens 235-260 33540058-1 2021 AChE inhibition caused by exposure to organophosphate (OP) compounds is strongly related to behavioral disorders such as depression. Organophosphates 38-53 acetylcholinesterase Rattus norvegicus 0-4 33545185-1 2021 Oxime reactivators of acetylcholinesterase (AChE) represent an integral part of standard antidote treatment of organophosphate poisoning. Organophosphates 111-126 acetylcholinesterase Rattus norvegicus 22-42 33545185-1 2021 Oxime reactivators of acetylcholinesterase (AChE) represent an integral part of standard antidote treatment of organophosphate poisoning. Organophosphates 111-126 acetylcholinesterase Rattus norvegicus 44-48 33581413-0 2021 Acetylcholinesterase activity and thyroid hormone levels in Ecuadorian adolescents living in agricultural settings where organophosphate pesticides are used. Organophosphates 121-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33581413-1 2021 BACKGROUND: Organophosphates are frequently applied insecticides that inhibit acetylcholinesterase (AChE) activity resulting in cholinergic overstimulation. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 33581413-1 2021 BACKGROUND: Organophosphates are frequently applied insecticides that inhibit acetylcholinesterase (AChE) activity resulting in cholinergic overstimulation. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 33581413-3 2021 We aimed to test the associations between AChE activity, a physiological marker of organophosphate exposure, and thyroid function in adolescents. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 33581413-9 2021 Lower AChE activity, indicating greater organophosphate exposure, was marginally associated with greater fT4 concentrations (difference per SD decrease in AChE activity (beta) = 0.03 ng/dL, [90% CI: 0.00, 0.06]) but not with TSH (beta = -0.01 muIU/ml, [-0.38, 0.36]). Organophosphates 40-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 33682265-1 2021 Past assassinations and terrorist attacks demonstrate the need for a more effective antidote against nerve agents and other organophosphates (OP) that cause brain damage through inhibition of acetylcholinesterase (AChE). Organophosphates 124-140 acetylcholinesterase Rattus norvegicus 192-212 33497710-1 2021 The mechanism of toxic action for organophosphates (OPs) is the persistent inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and subsequent hyperstimulation of the nervous system. Organophosphates 34-50 acetylcholinesterase Rattus norvegicus 89-109 33497710-1 2021 The mechanism of toxic action for organophosphates (OPs) is the persistent inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and subsequent hyperstimulation of the nervous system. Organophosphates 34-50 acetylcholinesterase Rattus norvegicus 111-115 33497710-1 2021 The mechanism of toxic action for organophosphates (OPs) is the persistent inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and subsequent hyperstimulation of the nervous system. Organophosphates 52-55 acetylcholinesterase Rattus norvegicus 89-109 33497710-1 2021 The mechanism of toxic action for organophosphates (OPs) is the persistent inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and subsequent hyperstimulation of the nervous system. Organophosphates 52-55 acetylcholinesterase Rattus norvegicus 111-115 33497710-6 2021 Organophosphates can stoichiometrically inhibit these enzymes, removing OPs from circulation thus providing protection for the target enzyme, AChE. Organophosphates 0-16 acetylcholinesterase Rattus norvegicus 142-146 33497710-6 2021 Organophosphates can stoichiometrically inhibit these enzymes, removing OPs from circulation thus providing protection for the target enzyme, AChE. Organophosphates 72-75 acetylcholinesterase Rattus norvegicus 142-146 33592259-0 2021 Reactivation of Organophosphate-inhibited Serum Butyrylcholinesterase by Novel Substituted Phenoxyalkyl Pyridinium Oximes and Traditional Oximes. Organophosphates 16-31 butyrylcholinesterase Homo sapiens 48-69 33682265-1 2021 Past assassinations and terrorist attacks demonstrate the need for a more effective antidote against nerve agents and other organophosphates (OP) that cause brain damage through inhibition of acetylcholinesterase (AChE). Organophosphates 124-140 acetylcholinesterase Rattus norvegicus 214-218 33638151-3 2021 Thus, the ideal cholinesterase reactivator should show minimal toxicity, limited inhibitory activity in the absence of an organophosphate, and rapid CNS penetration, in addition to its nucleophilic potential at the target, the conjugated AChE active center. Organophosphates 122-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-30 33748533-1 2021 Background: Cholinesterase inhibitor pesticides, especially organophosphates, are endocrine disruptors and a few existing studies have linked self-reports of exposure with increased depression and anxiety. Organophosphates 60-76 butyrylcholinesterase Homo sapiens 12-26 33086912-0 2021 IInteraction of organophosphate pesticide chlorpyrifos with alpha-2-macroglobulin: Biophysical and molecular docking approach. Organophosphates 16-31 alpha-2-macroglobulin Homo sapiens 60-81 33086912-3 2021 Our work focuses on the structural and functional alteration of alpha2M by chlorpyrifos (CPF), a member of organophosphates. Organophosphates 107-123 alpha-2-macroglobulin Homo sapiens 64-71 33583223-1 2021 Organophosphates are highly toxic compounds as they are involved in irreversible inhibition of acetylcholinesterase, causing various neurotoxic effects via acetylcholine accumulation throughout the nervous system. Organophosphates 0-16 ACE-1 Oryctolagus cuniculus 95-115 33670025-2 2021 The catalytic activity of PON proteins is directed toward artificial organophosphates and in physiological conditions toward thiolactones and oxidized phospholipids. Organophosphates 69-85 paraoxonase 1 Homo sapiens 26-29 31969002-2 2021 PON is known for its capacity to hydrolyze a wide range of substrates, including organophosphorus compounds, nerve gases, and aromatic carboxylic acid esters. Organophosphates 81-97 paraoxonase 1 Homo sapiens 0-3 33078895-0 2021 Organophosphate-pesticides induced survival mechanisms and APE1-mediated Nrf2 regulation in non-small-cell lung cancer cells. Organophosphates 0-15 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 59-63 33078895-0 2021 Organophosphate-pesticides induced survival mechanisms and APE1-mediated Nrf2 regulation in non-small-cell lung cancer cells. Organophosphates 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 33212192-2 2021 Organophosphates (OPs) irreversibly inhibit AChE, the enzyme responsible for termination of acetylcholine signal transduction. Organophosphates 0-16 acetylcholinesterase Cavia porcellus 44-48 33212192-2 2021 Organophosphates (OPs) irreversibly inhibit AChE, the enzyme responsible for termination of acetylcholine signal transduction. Organophosphates 18-21 acetylcholinesterase Cavia porcellus 44-48 33498605-12 2021 PC3 was associated with 30-days mortality, especially in organophosphate or carbamate poisoning. Organophosphates 57-72 chromobox 8 Homo sapiens 0-3 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 33484495-0 2021 Paraoxonase-1 (PON1) Status Analysis Using Non-Organophosphate Substrates. Organophosphates 47-62 paraoxonase 1 Homo sapiens 0-13 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 32334495-3 2021 When AChE is inhibited by OPs, its reactivation can be usually performed through cationic oximes. Organophosphates 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 33484495-2 2021 The ability of PON1 to hydrolyze specific organophosphate (OP) compounds and prevent accumulation of oxidized lipids in lipoproteins has prompted a large number of studies investigating PON1"s role in modulating toxicity and disease. Organophosphates 42-57 paraoxonase 1 Homo sapiens 15-19 33049692-2 2021 Acute exposure of humans to these mixtures induces the covalent modification of acetylcholinesterase (AChE) and neuropathy target esterase (NTE) and causes a cholinergic syndrome or organophosphate-induced delayed polyneuropathy syndrome (OPIDP). Organophosphates 182-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 33049692-2 2021 Acute exposure of humans to these mixtures induces the covalent modification of acetylcholinesterase (AChE) and neuropathy target esterase (NTE) and causes a cholinergic syndrome or organophosphate-induced delayed polyneuropathy syndrome (OPIDP). Organophosphates 182-197 patatin like phospholipase domain containing 6 Homo sapiens 140-143 33320798-0 2022 Organophosphate pesticide exposure among farm women and children: Status of micronutrients, acetylcholinesterase activity, and oxidative stress. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 33423231-1 2021 Acetylcholinesterase (AChE) is a useful biomarker for organophosphate and carbamate pesticides exposure. Organophosphates 54-69 acetylcholinesterase Danio rerio 0-20 33423231-1 2021 Acetylcholinesterase (AChE) is a useful biomarker for organophosphate and carbamate pesticides exposure. Organophosphates 54-69 acetylcholinesterase Danio rerio 22-26 33267602-6 2021 Low acetylcholinesterase levels confirmed organophosphate poisoning. Organophosphates 42-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 33158102-0 2020 Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers. Organophosphates 20-35 insulin Homo sapiens 59-66 32949634-1 2020 Two polyhydroxyfullerenes, which decrease organophosphate (OP)-induced acetylcholinesterase (AChE) inhibition in vitro, were administered by the intraperitoneal (ip) route or applied topically at doses of 0.9-24 mg/kg to protect adult male mice from enzyme-inhibiting and behavioral effects indicative of OP toxicity resulting from exposure to 1.7 - 2 mg/kg diphosphorofluoridate (DFP) ip or 2.3 - 2.7 mg paraoxon topical. Organophosphates 42-57 acetylcholinesterase Mus musculus 93-97 32512455-4 2020 Here, we investigated the function of CYP321A16 and CYP332A1 in resistance to the organophosphate insecticide, chlorpyrifos and their regulation by the transcription factors CncC and Maf. Organophosphates 82-97 cap-n-collar Drosophila melanogaster 174-178 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Organophosphates 169-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Organophosphates 169-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32949615-2 2020 Harmful effects of OPs on health have been attributed primarily for irreversible inhibition of acetylcholinesterase (AChE) at nerve synapse. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 32949615-2 2020 Harmful effects of OPs on health have been attributed primarily for irreversible inhibition of acetylcholinesterase (AChE) at nerve synapse. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 32949615-3 2020 However, studies have shown that inhibition of AChE alone cannot explain all the maladies encountered in prolonged exposure to OPs. Organophosphates 127-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 32949615-10 2020 IL6, TNFalpha,CRP were increased and Apo AI was less while Apo B was increased in OP exposed groups in both population groups SNPs analysis of PON1 showed significant differences in allelic and genotype frequencies of OPs exposed and non-exposed groups. Organophosphates 218-221 interleukin 6 Homo sapiens 0-3 32949615-10 2020 IL6, TNFalpha,CRP were increased and Apo AI was less while Apo B was increased in OP exposed groups in both population groups SNPs analysis of PON1 showed significant differences in allelic and genotype frequencies of OPs exposed and non-exposed groups. Organophosphates 218-221 apolipoprotein A1 Homo sapiens 37-43 32949615-10 2020 IL6, TNFalpha,CRP were increased and Apo AI was less while Apo B was increased in OP exposed groups in both population groups SNPs analysis of PON1 showed significant differences in allelic and genotype frequencies of OPs exposed and non-exposed groups. Organophosphates 218-221 apolipoprotein B Homo sapiens 59-64 32949615-10 2020 IL6, TNFalpha,CRP were increased and Apo AI was less while Apo B was increased in OP exposed groups in both population groups SNPs analysis of PON1 showed significant differences in allelic and genotype frequencies of OPs exposed and non-exposed groups. Organophosphates 218-221 paraoxonase 1 Homo sapiens 143-147 31910701-3 2020 The AChE reactivation for all used organophosphates was found negligible if compared to the reactivation ability of obidoxime. Organophosphates 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 33175189-1 2020 A photothermal and fluorescent dual-mode assay for sensitive organophosphate pesticides (Ops) determination is reported based on alkaline phosphatase (ALP)-inhibition-induced formation of polydopamine (PDA) nanoparticles. Organophosphates 61-76 alkaline phosphatase, placental Homo sapiens 129-149 33175189-1 2020 A photothermal and fluorescent dual-mode assay for sensitive organophosphate pesticides (Ops) determination is reported based on alkaline phosphatase (ALP)-inhibition-induced formation of polydopamine (PDA) nanoparticles. Organophosphates 61-76 alkaline phosphatase, placental Homo sapiens 151-154 33158102-3 2020 This cross-sectional study aimed to evaluate the association between organophosphate exposure and insulin resistance in pesticide sprayers and nonfarmworkers. Organophosphates 69-84 insulin Homo sapiens 98-105 33158102-2 2020 Chronic organophosphate exposure has been reported to be a cause of insulin resistance in animal models. Organophosphates 8-23 insulin Homo sapiens 68-75 32961558-0 2020 Organophosphate Flame Retardants Excite Arcuate Melanocortin Circuitry and Increase Neuronal Sensitivity to Ghrelin in Adult Mice. Organophosphates 0-15 ghrelin Mus musculus 108-115 32319115-1 2020 Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally. Organophosphates 71-87 acetylcholinesterase Rattus norvegicus 131-151 32319115-1 2020 Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally. Organophosphates 71-87 acetylcholinesterase Rattus norvegicus 153-157 32319115-1 2020 Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally. Organophosphates 89-92 acetylcholinesterase Rattus norvegicus 131-151 32319115-1 2020 Oximes remain a long-standing element of the therapy for nerve agents, organophosphates (OPs) that poison by inhibiting the enzyme acetylcholinesterase (AChE), resulting in hypercholinergic activity both centrally and peripherally. Organophosphates 89-92 acetylcholinesterase Rattus norvegicus 153-157 32436233-1 2020 Oxime antidotes regenerate organophosphate-inhibited acetylcholinesterase (AChE). Organophosphates 27-42 acetylcholinesterase Rattus norvegicus 53-73 32436233-1 2020 Oxime antidotes regenerate organophosphate-inhibited acetylcholinesterase (AChE). Organophosphates 27-42 acetylcholinesterase Rattus norvegicus 75-79 32749514-0 2020 Neurite outgrowth inhibitory levels of organophosphates induce tissue transglutaminase activity in differentiating N2a cells: evidence for covalent adduct formation. Organophosphates 39-55 transglutaminase 2, C polypeptide Mus musculus 63-86 32650030-2 2020 This study evaluated the hypothesis that DJ-1 sustains brainstem cardiovascular regulation via maintaining mitochondrial function in the rostral ventrolateral medulla (RVLM), a brainstem site known to maintain blood pressure and sympathetic vasomotor tone, during cardiovascular depression elicited by the organophosphate insecticide mevinphos. Organophosphates 306-321 Parkinsonism associated deglycase Rattus norvegicus 41-45 32648216-1 2020 Exposure to organophosphate pesticides (OP) has been associated with the inhibition of cholinesterase enzymatic activity, such as butyrylcholinesterase (BuChE). Organophosphates 12-27 butyrylcholinesterase Homo sapiens 87-101 32648216-1 2020 Exposure to organophosphate pesticides (OP) has been associated with the inhibition of cholinesterase enzymatic activity, such as butyrylcholinesterase (BuChE). Organophosphates 12-27 butyrylcholinesterase Homo sapiens 130-151 32648216-1 2020 Exposure to organophosphate pesticides (OP) has been associated with the inhibition of cholinesterase enzymatic activity, such as butyrylcholinesterase (BuChE). Organophosphates 12-27 butyrylcholinesterase Homo sapiens 153-158 32454274-7 2020 Overall, the developed protocols prove SB as highly sensitive, selective and recyclable "pick and degrade" probe for the recognition and degradation of OPs. Organophosphates 152-155 protein interacting with PRKCA 1 Homo sapiens 89-93 33024231-0 2020 Slow-binding reversible inhibitor of acetylcholinesterase with long-lasting action for prophylaxis of organophosphate poisoning. Organophosphates 102-117 acetylcholinesterase Mus musculus 37-57 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32632029-1 2020 OBJECTIVES: The risk of diabetes mellitus may be elevated among persons exposed to some pesticides, including cholinesterase-inhibiting insecticides (organophosphates and carbamates). Organophosphates 150-166 butyrylcholinesterase Homo sapiens 110-124 32632029-6 2020 Exposure to organophosphate and carbamate insecticides was quantified using erythrocyte acetylcholinesterase normalised by haemoglobin (AChE/Hb). Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 32835730-4 2020 Being lipophilic compounds, organophosphates readily penetrate the brain and block the enzyme acetylcholinesterase (AChE). Organophosphates 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32835730-4 2020 Being lipophilic compounds, organophosphates readily penetrate the brain and block the enzyme acetylcholinesterase (AChE). Organophosphates 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 33015048-8 2020 Proteomic analyses of selective GSK3b inhibition in calcifying human aortic valve interstitial cells (HAVICs) revealed enrichment of proteins involved organophosphate metabolism, while reducing the activation of pathogenic biomolecular processes. Organophosphates 151-166 glycogen synthase kinase 3 beta Homo sapiens 32-37 32976529-1 2020 The levels and activity of the enzyme paraoxonase 1 affect the vulnerability to the teratogenic effects of organophosphate pesticides. Organophosphates 107-122 paraoxonase 1 Mus musculus 38-51 32544483-0 2020 Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes. Organophosphates 31-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32544483-1 2020 This review provides an overview of the global research leading to the large number of compounds developed as reactivators of acetylcholinesterase inhibited by a variety of organophosphate compounds, most of which are nerve agents but also some insecticides. Organophosphates 173-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 32943846-1 2020 Purpose: Human butyrylcholinesterase (BChE) serves as a bio scavenger to counteract organophosphate poisoning. Organophosphates 84-99 butyrylcholinesterase Homo sapiens 15-36 32891393-9 2020 The sensitive HPTLC-S9-AChE assay allowed the detection of neurotoxic chemicals with and without metabolic activation, at levels consistent with the threshold of toxicological concern of organophosphates and carbamates. Organophosphates 187-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 32943846-1 2020 Purpose: Human butyrylcholinesterase (BChE) serves as a bio scavenger to counteract organophosphate poisoning. Organophosphates 84-99 butyrylcholinesterase Homo sapiens 38-42 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Organophosphates 32-48 butyrylcholinesterase Homo sapiens 0-14 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 27-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 27-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Organophosphates 32-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Organophosphates 32-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 32643373-0 2020 In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages. Organophosphates 27-42 GLI family zinc finger 2 Homo sapiens 69-74 32302901-1 2020 Organophosphates insecticides (OPs) are one of the major environmental pollutants and their interaction with human serum albumin (HSA) has been shown to have significant effects on their bioavailability which is related to toxicokinetics and toxicodynamics in human body. Organophosphates 0-16 albumin Homo sapiens 115-128 32229401-5 2020 Detection of organophosphates are successfully achieved as they are potent inhibitors of AChE. Organophosphates 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 32551623-1 2020 Acetylcholinesterase inactivating compounds, such as organophosphate (OP) and carbamate (CM) pesticides, are widely used in agriculture to ensure sustainable production of food and feed. Organophosphates 53-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32305437-0 2020 Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A. Organophosphates 47-62 cathepsin A Homo sapiens 83-94 32305437-2 2020 CatA can remove the C-terminal amino acids of endothelin I, angiotensin I, Substance P, oxytocin, and bradykinin, and can deamidate neurokinin A. Proteomic studies identified CatA and its homologue SCPEP1 as potential targets of organophosphates (OP). Organophosphates 229-245 cathepsin A Homo sapiens 0-4 32305437-2 2020 CatA can remove the C-terminal amino acids of endothelin I, angiotensin I, Substance P, oxytocin, and bradykinin, and can deamidate neurokinin A. Proteomic studies identified CatA and its homologue SCPEP1 as potential targets of organophosphates (OP). Organophosphates 229-245 cathepsin A Homo sapiens 175-179 32381396-0 2020 Synthesis, biochemical evaluation, and molecular modeling of organophosphate-coumarin hybrids as potent and selective butyrylcholinesterase inhibitors. Organophosphates 61-76 butyrylcholinesterase Homo sapiens 118-139 32381396-4 2020 Reversed selectivity and a 100-fold reduction in anti-BChE activity was observed when the organophosphate was attached to the benzyl instead of the coumarin. Organophosphates 90-105 butyrylcholinesterase Homo sapiens 54-58 32388435-0 2020 Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates. Organophosphates 123-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 32604835-0 2020 Phylogeography of Organophosphate Resistant ace Alleles in Spanish Olive Fruit Fly Populations: A Mediterranean Perspective in the Global Change Context. Organophosphates 18-33 acetylcholinesterase Bactrocera oleae 44-47 32333945-5 2020 Therefore, this review focuses on oxime-assisted catalysis by AChE mutants that provides a potential means for degradation of organophosphates in the plasma before reaching the cellular target site. Organophosphates 126-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 32361078-0 2020 Association between cholinesterase"s inhibition and cognitive impairment: A basis for prevention policies of environmental pollution by organophosphate and carbamate pesticides in Chile. Organophosphates 136-151 butyrylcholinesterase Homo sapiens 20-34 32278739-0 2020 Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM. Organophosphates 48-63 peptidylglycine alpha-amidating monooxygenase Homo sapiens 107-110 32546061-1 2020 Previously, sex-dependent alterations in energy homeostasis were reported in adult mice fed a standard chow attributed to exposure to a mixture of organophosphate flame retardants (OPFRs) via estrogen receptors (ERalpha). Organophosphates 147-162 estrogen receptor 1 (alpha) Mus musculus 212-219 32279763-1 2020 Herein we report a multiplated and biopolymeric-based optical bioassay for organophosphate detection based on the use of acetylcholinesterase (AChE) as biocomponent and biopolymeric electrospun fibrous mats as eco-designed supports for AChE immobilisation. Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 32109818-12 2020 Organophosphate poisoning can cause a lot of nuclear disintegration of brain neurons, increases cell apoptosis, disrupts the energy metabolism of mitochondrial structure, and inhibits the AMPK signaling pathway. Organophosphates 0-15 protein kinase AMP-activated catalytic subunit alpha 1 Gallus gallus 188-192 32359085-1 2020 Organophosphate (OP) compounds constitute a class of highly toxic molecules, characterized by irreversible cholinesterase (ChE) inhibition. Organophosphates 0-15 butyrylcholinesterase Mus musculus 107-121 32359085-1 2020 Organophosphate (OP) compounds constitute a class of highly toxic molecules, characterized by irreversible cholinesterase (ChE) inhibition. Organophosphates 0-15 butyrylcholinesterase Mus musculus 123-126 31808570-3 2020 The first part of this review concentrated primarily on the computation of 31 P NMR chemical shifts, whereas the second part concerns the calculation of spin-spin coupling constants involving phosphorus nucleus, focusing primarily on their stereochemical dependencies and stereodynamic behavior in particular classes of organophosphorus compounds. Organophosphates 320-336 spindlin 1 Homo sapiens 153-157 32279763-1 2020 Herein we report a multiplated and biopolymeric-based optical bioassay for organophosphate detection based on the use of acetylcholinesterase (AChE) as biocomponent and biopolymeric electrospun fibrous mats as eco-designed supports for AChE immobilisation. Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 32279763-1 2020 Herein we report a multiplated and biopolymeric-based optical bioassay for organophosphate detection based on the use of acetylcholinesterase (AChE) as biocomponent and biopolymeric electrospun fibrous mats as eco-designed supports for AChE immobilisation. Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-240 31954867-1 2020 Organophosphorus nerve agents (NA) inhibit acetylcholinesterase (AChE) which results in the over-stimulation of both the central and peripheral nervous systems, creating a toxic syndrome that can be lethal if left untreated (Cannard, 2006). Organophosphates 0-16 acetylcholinesterase Cavia porcellus 43-63 32213749-0 2020 Effects of several organophosphates on hepatic cytochrome P450 activities in rats. Organophosphates 19-35 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 47-62 31954867-1 2020 Organophosphorus nerve agents (NA) inhibit acetylcholinesterase (AChE) which results in the over-stimulation of both the central and peripheral nervous systems, creating a toxic syndrome that can be lethal if left untreated (Cannard, 2006). Organophosphates 0-16 acetylcholinesterase Cavia porcellus 65-69 31694074-1 2020 The inhibition of acetylcholinesterase (AChE) is a common outcome caused by organophosphorus (OPs) intoxication. Organophosphates 76-92 acetylcholinesterase Rattus norvegicus 18-38 32385098-0 2020 Correction: Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. Organophosphates 100-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 31692155-1 2020 Organophosphorus (OP)-based nerve agents are extremely toxic and potent acetylcholinesterase inhibitors and recent attacks involving nerve agents highlight the need for fast detection and intervention. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 32348360-0 2020 Acetylcholinesterase electrochemical biosensors with graphene-transition metal carbides nanocomposites modified for detection of organophosphate pesticides. Organophosphates 129-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32114288-8 2020 Quantitative inter-individual differences in PON1 activity are important for chemical risk assessment particularly with regards to the potential sensitivity to organophosphates" toxicity. Organophosphates 160-176 paraoxonase 1 Homo sapiens 45-49 31694074-1 2020 The inhibition of acetylcholinesterase (AChE) is a common outcome caused by organophosphorus (OPs) intoxication. Organophosphates 76-92 acetylcholinesterase Rattus norvegicus 40-44 31694074-1 2020 The inhibition of acetylcholinesterase (AChE) is a common outcome caused by organophosphorus (OPs) intoxication. Organophosphates 94-97 acetylcholinesterase Rattus norvegicus 18-38 31694074-1 2020 The inhibition of acetylcholinesterase (AChE) is a common outcome caused by organophosphorus (OPs) intoxication. Organophosphates 94-97 acetylcholinesterase Rattus norvegicus 40-44 31884214-2 2020 Most target organophosphate esters (OPEs) were found in water samples, with average concentrations of 787 ng/L for triethyl phosphate (TEP) and 0.1 ng/L for tripropyl phosphate (TPP) in wastewater, 1.48 x 103 ng/L for TEP and 0.12 ng/L for tripentyl phosphate (TPeP) in river water, and 15.5 ng/L for tris(2-chloroethyl) phosphate (TCEP) and 0.08 ng/L for tritolyl phosphate (TMPP) in tap water. Organophosphates 36-40 transporter associated with antigen processing, subunit type c Danio rerio 385-388 31884214-5 2020 In addition, the binding affinity between OPEs and a thyroid hormone receptor (TRbeta) protein was further investigated by molecular docking modeling, which helped to estimate the effects of OPEs on TRbeta. Organophosphates 42-46 thyroid hormone receptor beta Danio rerio 79-85 31884214-5 2020 In addition, the binding affinity between OPEs and a thyroid hormone receptor (TRbeta) protein was further investigated by molecular docking modeling, which helped to estimate the effects of OPEs on TRbeta. Organophosphates 42-46 thyroid hormone receptor beta Danio rerio 199-205 31884214-5 2020 In addition, the binding affinity between OPEs and a thyroid hormone receptor (TRbeta) protein was further investigated by molecular docking modeling, which helped to estimate the effects of OPEs on TRbeta. Organophosphates 191-195 thyroid hormone receptor beta Danio rerio 79-85 31884214-5 2020 In addition, the binding affinity between OPEs and a thyroid hormone receptor (TRbeta) protein was further investigated by molecular docking modeling, which helped to estimate the effects of OPEs on TRbeta. Organophosphates 191-195 thyroid hormone receptor beta Danio rerio 199-205 31965510-1 2020 Chlorpyrifos is an organophosphate pesticide whose exposure leads to inhibition of acetylcholinesterase (AChE) enzyme and induces oxidative stress, inflammation, and neurotoxicity. Organophosphates 19-34 acetylcholinesterase Mus musculus 83-103 31933077-1 2020 Malathion is a potent organophosphate insecticide that inhibits acetylcholinesterase (AChE) enzyme. Organophosphates 22-37 acetylcholinesterase Rattus norvegicus 64-84 31965510-1 2020 Chlorpyrifos is an organophosphate pesticide whose exposure leads to inhibition of acetylcholinesterase (AChE) enzyme and induces oxidative stress, inflammation, and neurotoxicity. Organophosphates 19-34 acetylcholinesterase Mus musculus 105-109 31933077-1 2020 Malathion is a potent organophosphate insecticide that inhibits acetylcholinesterase (AChE) enzyme. Organophosphates 22-37 acetylcholinesterase Rattus norvegicus 86-90 32019865-0 2020 Rational design, synthesis and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32031197-0 2020 Acetylcholinesterase-catalyzed silver deposition for ultrasensitive electrochemical biosensing of organophosphorus pesticides. Organophosphates 98-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32031197-1 2020 Herein, an electrochemical biosensing platform with acetylcholinesterase (AChE)-catalyzed silver deposition was developed for the ultrasensitive detection of organophosphorus pesticides (OPs). Organophosphates 158-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 32031197-1 2020 Herein, an electrochemical biosensing platform with acetylcholinesterase (AChE)-catalyzed silver deposition was developed for the ultrasensitive detection of organophosphorus pesticides (OPs). Organophosphates 158-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 31863869-3 2020 A related enzyme, butyrylcholinesterase (BChE), may act in the CNS as a co-regulator in terminating nerve impulses and is a natural plasma scavenger upon exposure to organophosphate (OP) nerve agents that irreversibly inhibit both enzymes. Organophosphates 166-181 butyrylcholinesterase Homo sapiens 18-39 31863869-3 2020 A related enzyme, butyrylcholinesterase (BChE), may act in the CNS as a co-regulator in terminating nerve impulses and is a natural plasma scavenger upon exposure to organophosphate (OP) nerve agents that irreversibly inhibit both enzymes. Organophosphates 166-181 butyrylcholinesterase Homo sapiens 41-45 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 31092058-4 2020 One of these patients had reduced levels of butyrylcholinesterase after a flight suggesting exposure to organophosphate compounds had occurred. Organophosphates 104-119 butyrylcholinesterase Homo sapiens 44-65 31791835-1 2020 Pellets with an immobilized enzyme (acetyl- or butyrylcholinesterase) are the up-to-date type of carriers used for the detection of nerve agents (soman, sarin, tabun, VX, Novichok) and other cholinesterase inhibitors such as organophosphate and carbamate insecticides (parathion, malathion). Organophosphates 225-240 butyrylcholinesterase Homo sapiens 54-68 31092058-5 2020 All three were found to have elevated neuronal and glial auto-antibodies, biomarkers of central nervous system injury, and all three had genetic polymorphisms of paraoxonase (PON-1) and two of cytochrome P450, leading to a reduced ability to metabolize organophosphate compound (OPs).Discussion: A similar constellation of symptoms has been described in other studies of aircrew, although objective evidence of exposure is lacking in most of these studies. Organophosphates 253-268 paraoxonase 1 Homo sapiens 175-180 31092058-5 2020 All three were found to have elevated neuronal and glial auto-antibodies, biomarkers of central nervous system injury, and all three had genetic polymorphisms of paraoxonase (PON-1) and two of cytochrome P450, leading to a reduced ability to metabolize organophosphate compound (OPs).Discussion: A similar constellation of symptoms has been described in other studies of aircrew, although objective evidence of exposure is lacking in most of these studies. Organophosphates 253-268 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 193-208 31532269-0 2020 Validation and kinetic of enzymatic method for the detection of organophosphate insecticides based on cholinesterase inhibition. Organophosphates 64-79 butyrylcholinesterase Homo sapiens 102-116 32113603-3 2020 Although this potent cholinesterase inhibitor was first reported in the 1970s and connected with animal poisonings, the lack of chemical standards and identified biosynthetic genes together with limited diagnostics and acute reactivity of this naturally-occurring organophosphate have limited our understanding of its environmental breadth and human health implications. Organophosphates 264-279 butyrylcholinesterase Homo sapiens 21-35 31973869-0 2020 In vitro interaction of organophosphate metabolites with bovine serum albumin: A comparative 1H NMR, fluorescence and molecular docking analysis. Organophosphates 24-39 albumin Homo sapiens 64-77 31973869-2 2020 Here, considering bovine serum albumin (BSA) as a model protein, we have examined its interaction with two selected organophosphate metabolites, 3,5,6-trichloro-2-pyridinol (TCPy) and paraoxon methyl (PM). Organophosphates 116-131 albumin Homo sapiens 25-38 31973869-10 2020 The result provides key insights into the direct interaction of the organophosphate metabolites with a biologically important carrier protein, serum albumin. Organophosphates 68-83 albumin Homo sapiens 143-156 31857189-1 2020 V-type agents are highly toxic organophosphorus nerve agents that inhibit acetylcholinesterase in the nervous system, causing a series of poison symptoms. Organophosphates 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 31675511-1 2020 New uncharged conjugates of 6-methyluracil derivatives with imidazole-2-aldoxime and 1,2,4-triazole-3-hydroxamic acid units were synthesized and studied as reactivators of organophosphate-inhibited cholinesterase. Organophosphates 172-187 butyrylcholinesterase Homo sapiens 198-212 31677527-1 2020 Acetylcholinesterase (AChE) has been widely applied on the enzyme inhibition-based detection of organophosphate pesticides (OPs). Organophosphates 96-111 Acetylcholine esterase Drosophila melanogaster 22-26 31628910-3 2020 In this study the stoichiometric nature of the protection afforded by human butyrylcholinesterase against organophosphorus nerve agents was investigated in guinea pigs. Organophosphates 106-122 butyrylcholinesterase Homo sapiens 76-97 31706600-5 2020 When children are exposed to cigarette smoke, bisphenol A (BPA), or organophosphate pesticides, MAOA activity is inhibited. Organophosphates 68-83 monoamine oxidase A Homo sapiens 96-100 31707227-3 2020 This study showed that IL-23 Aptamer could reduce the clinical development of brain inflammation induced by Parathion, as an important organophosphate toxin. Organophosphates 135-150 interleukin 23, alpha subunit p19 Mus musculus 23-28 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Organophosphates 32-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Organophosphates 32-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31979959-0 2020 Pseudocholinesterase Levels as a Prognostic Marker in Organophosphorous Compound Poisoning. Organophosphates 54-71 butyrylcholinesterase Homo sapiens 0-20 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Organophosphates 13-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 33442173-11 2020 Conclusion: Organophosphate pesticide exposure lowered erythrocyte AChE activity and increased oxidative stress. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 31703066-5 2019 The results show that OPs penetrated the model blood brain barrier (BBB) and inhibited AChE activity. Organophosphates 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 31158460-2 2020 The goal was reactivation of inhibited brain acetylcholinesterase to attenuate the organophosphate-induced hypercholinergic activity that results in glutamate-mediated excitotoxicity and neuropathology. Organophosphates 83-98 acetylcholinesterase Rattus norvegicus 45-65 31816846-1 2019 Spanning three decades in research, Paraoxonases (PON1) carried potential of dealing with neurotoxicity of organophosphates entering the circulation and preventing cholinergic crisis. Organophosphates 107-123 paraoxonase 1 Homo sapiens 50-54 31642715-3 2019 Inhibition of cholinesterase, primarily butyrylcholinesterase is a good indicator of occupational exposure to organophosphates and carbamates.Objective: This case-control study aims to study the risks associated with pesticide exposure among farmers and agricultural workers in the Souss Massa region by analyzing variations in the response of a pesticides exposure biomarker: Serum Cholinesterase Activity (butyrylcholinesterase (BChE)).Materials and methods: This was a prospective study conducted on 133 participants (71 farmers and 62 non-farmers). Organophosphates 110-126 butyrylcholinesterase Homo sapiens 14-28 31642715-3 2019 Inhibition of cholinesterase, primarily butyrylcholinesterase is a good indicator of occupational exposure to organophosphates and carbamates.Objective: This case-control study aims to study the risks associated with pesticide exposure among farmers and agricultural workers in the Souss Massa region by analyzing variations in the response of a pesticides exposure biomarker: Serum Cholinesterase Activity (butyrylcholinesterase (BChE)).Materials and methods: This was a prospective study conducted on 133 participants (71 farmers and 62 non-farmers). Organophosphates 110-126 butyrylcholinesterase Homo sapiens 40-61 31642715-9 2019 A proportion (11.3%) of farmers also reported that empty container waste is spilled on the farm.Conclusions: The decrease in BChE indicates a serious public health problem among farmers who use organophosphate pesticides. Organophosphates 194-209 butyrylcholinesterase Homo sapiens 125-129 31765413-0 2019 Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning. Organophosphates 83-98 butyrylcholinesterase Homo sapiens 52-73 31765413-7 2019 Sustained expression of hBChE provided dose-dependent protection against VX in male and female mice despite detectable antibodies to hBChE in some mice, thereby demonstrating that expression of hBChE in vivo in mouse muscle is an effective prophylactic against organophosphate poisoning. Organophosphates 261-276 butyrylcholinesterase Homo sapiens 24-29 31243662-1 2019 Paraoxonase 1 (PON1) is an A-esterase calcium-dependent enzyme that is associated with high-density lipoprotein (HDL) and capable of hydrolyzing a wide variety of substrates, including organophosphate (OP) pesticides. Organophosphates 185-200 paraoxonase 1 Homo sapiens 0-13 31408696-1 2019 Eye exposure to organophosphate (OP) chemical warfare irreversible acetylcholinesterase inhibitors, results in long-term miosis and impaired visual function. Organophosphates 16-31 acetylcholinesterase Rattus norvegicus 67-87 31556693-0 2019 Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase. Organophosphates 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 31556693-1 2019 Aim: Organophosphorus compounds are irreversible inhibitors of acetylcholinesterase. Organophosphates 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 31315019-4 2019 The hydrophobicity of organophosphate pesticides is correlated significantly to TSPO binding affinity, mitochondrial membrane potential reduction in HepG2 cells, and developmental toxicity in Caenorhabditis elegans and Danio rerio (p < 0.05). Organophosphates 22-37 translocator protein Homo sapiens 80-84 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Organophosphates 25-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Organophosphates 25-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 76-97 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 99-103 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 18-21 butyrylcholinesterase Homo sapiens 76-97 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 18-21 butyrylcholinesterase Homo sapiens 99-103 31082780-3 2019 Total organophosphate pesticides concentrations ranged from 0.12 to 65.09 ng L-1 in water (as the sum of the water dissolved phase and suspended particulate matter) and from 1.19 to 23.17 ng g-1 in sediment samples. Organophosphates 6-21 immunoglobulin kappa variable 1-16 Homo sapiens 77-80 31152871-1 2019 BACKGROUND: The most commonly used insecticides and pesticides worldwide are organophosphate compounds, chemicals that irreversibly inhibit the cholinesterase enzyme. Organophosphates 77-92 butyrylcholinesterase Rattus norvegicus 144-158 31100277-1 2019 Since the development in the 1950"s of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved congeneric pyridinium aldoximes. Organophosphates 89-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 30981910-1 2019 Acetylcholinesterase (AChE) plays an important role in the therapy of Alzheimer"s disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. Organophosphates 133-149 acetylcholinesterase Danio rerio 0-20 30981910-1 2019 Acetylcholinesterase (AChE) plays an important role in the therapy of Alzheimer"s disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. Organophosphates 133-149 acetylcholinesterase Danio rerio 22-26 31243662-1 2019 Paraoxonase 1 (PON1) is an A-esterase calcium-dependent enzyme that is associated with high-density lipoprotein (HDL) and capable of hydrolyzing a wide variety of substrates, including organophosphate (OP) pesticides. Organophosphates 185-200 paraoxonase 1 Homo sapiens 15-19 31374903-0 2019 A Re-Evaluation of Olive Fruit Fly Organophosphate-Resistant Ace Alleles in Iberia, and Field-Testing Population Effects after in-Practice Dimethoate Use. Organophosphates 35-50 acetylcholinesterase Bactrocera oleae 61-64 31363918-7 2019 If organophosphates are present, the activity of AChE becomes increasingly blocked, and this leads to a less expressed IFE and an increasing recovery of fluorescence. Organophosphates 3-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 31202795-2 2019 Cholinesterase inhibitor pesticides (e.g. organophosphates) appear to increase depression and anxiety symptoms in the few existing animal and human studies. Organophosphates 42-58 butyrylcholinesterase Homo sapiens 0-14 31009643-4 2019 QM/MM modeling performed for the reaction of wild-type BChE and double mutant with echothiophate showed high reactivity of the mutant towards the organophosphate. Organophosphates 146-161 butyrylcholinesterase Homo sapiens 55-59 30927662-1 2019 Tris(1,3-dichloropropyl) phosphate (TDCPP, CAS 13674-87-8) is one of the most commonly used organophosphate flame retardants (OPFRs) in cars, residential furniture and other products containing polyurethane foam to meet the required flammability standards. Organophosphates 92-107 BCAR1 scaffold protein, Cas family member Homo sapiens 43-46 31121152-2 2019 The novel prophylactic agent 7-methoxytacrine-4-pyridinealdoxime is a hybrid compound formerly designed to keep acetylcholinesterase resistant to organophosphates by reactivating it in case of intoxication by such inhibitors. Organophosphates 146-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 30831354-0 2019 A sensitive amperometric AChE-biosensor for organophosphate pesticides detection based on conjugated polymer and Ag-rGO-NH2 nanocomposite. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 31109643-1 2019 BACKGROUND: Paraoxonase 1 (PON1) is an antiatherogenic and organophosphate hydrolyzer enzyme. Organophosphates 59-74 paraoxonase 1 Homo sapiens 27-31 30890431-1 2019 Diazinon (DZN) is an organophosphate pesticide characterized by inhibiting the enzyme acetylcholinesterase (AChE) (E.C. Organophosphates 21-36 acetylcholinesterase Oreochromis niloticus 86-106 30890431-1 2019 Diazinon (DZN) is an organophosphate pesticide characterized by inhibiting the enzyme acetylcholinesterase (AChE) (E.C. Organophosphates 21-36 acetylcholinesterase Oreochromis niloticus 108-112 30978400-1 2019 Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Organophosphates 46-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 31109643-1 2019 BACKGROUND: Paraoxonase 1 (PON1) is an antiatherogenic and organophosphate hydrolyzer enzyme. Organophosphates 59-74 paraoxonase 1 Homo sapiens 12-25 30993792-1 2019 Serving a critical role in neurotransmission, human acetylcholinesterase (hAChE) is the target of organophosphate nerve agents. Organophosphates 98-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-79 30978400-1 2019 Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Organophosphates 46-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 30639397-5 2019 Our present study revealed that in the cAMP-induced differentiation of C6 cells, an AChR antagonist alleviated the expression of glia fibrillary acidic protein (GFAP) that had been suppressed by dichlorvos (DDVP), an organophosphate and an AChE inhibitor. Organophosphates 217-232 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 84-88 30926319-1 2019 Human butyrylcholinesterase (BChE) is a well-characterized bioscavenger with significant potential as a prophylactic or post-exposure treatment for organophosphate poisoning. Organophosphates 148-163 butyrylcholinesterase Homo sapiens 29-33 30771950-0 2019 Mass spectrometry based proteomic approach for the screening of butyrylcholinesterase adduct formation with organophosphates. Organophosphates 108-124 butyrylcholinesterase Homo sapiens 64-85 30771950-1 2019 Organophosphates" toxic effect causes covalent binding to serine-198 in the active site of human plasma butyrylcholinesterase (BChE) with loss of enzymatic function (covalent inhibition). Organophosphates 0-16 butyrylcholinesterase Homo sapiens 104-125 30771950-1 2019 Organophosphates" toxic effect causes covalent binding to serine-198 in the active site of human plasma butyrylcholinesterase (BChE) with loss of enzymatic function (covalent inhibition). Organophosphates 0-16 butyrylcholinesterase Homo sapiens 127-131 30714192-3 2019 Plant protection products such as neonicotinoids, pyrethroids, and organophosphates alter the transcriptional expression of vitellogenin. Organophosphates 67-83 vitellogenin Apis mellifera 124-136 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 32254993-1 2019 Colorimetric detection of acetylcholinesterase (AChE) and its inhibitor organophosphates (OPs) is attractive for its convenience, but the addition of exogenous catalyst to produce a chromogenic agent may result in complexity and interference. Organophosphates 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 32254993-1 2019 Colorimetric detection of acetylcholinesterase (AChE) and its inhibitor organophosphates (OPs) is attractive for its convenience, but the addition of exogenous catalyst to produce a chromogenic agent may result in complexity and interference. Organophosphates 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 30639397-5 2019 Our present study revealed that in the cAMP-induced differentiation of C6 cells, an AChR antagonist alleviated the expression of glia fibrillary acidic protein (GFAP) that had been suppressed by dichlorvos (DDVP), an organophosphate and an AChE inhibitor. Organophosphates 217-232 glial fibrillary acidic protein Rattus norvegicus 161-165 30975138-2 2019 Organophosphate pesticides (OP) can act as thyroid disruptors and genetic polymorphisms for paraoxonase 1 (PON1), an enzyme that detoxifies OP, could be involved in individual"s susceptibility to them. Organophosphates 0-15 paraoxonase 1 Homo sapiens 92-105 30995784-8 2019 Both organophosphates decreased cholinesterase activities from 10 to 180 min post-injection with the same degree of inhibition of total cholinesterase within an onset at the same times after injection. Organophosphates 5-21 butyrylcholinesterase Rattus norvegicus 32-46 30995784-8 2019 Both organophosphates decreased cholinesterase activities from 10 to 180 min post-injection with the same degree of inhibition of total cholinesterase within an onset at the same times after injection. Organophosphates 5-21 butyrylcholinesterase Rattus norvegicus 136-150 30975138-2 2019 Organophosphate pesticides (OP) can act as thyroid disruptors and genetic polymorphisms for paraoxonase 1 (PON1), an enzyme that detoxifies OP, could be involved in individual"s susceptibility to them. Organophosphates 0-15 paraoxonase 1 Homo sapiens 107-111 30944532-5 2019 However, the brain tissue AChE activity level in wild birds exposed to organophosphate (OP) pesticide was 48.0%-96.3% of that in the normal birds. Organophosphates 71-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30972027-3 2019 MVs contain high activity of tissue non-specific alkaline phosphatase (TNSALP), which hydrolyzes phosphoric esters such as pyrophosphates (PPi) to produce inorganic orthophosphates (Pi). Organophosphates 97-114 alkaline phosphatase, biomineralization associated Homo sapiens 29-69 30972027-3 2019 MVs contain high activity of tissue non-specific alkaline phosphatase (TNSALP), which hydrolyzes phosphoric esters such as pyrophosphates (PPi) to produce inorganic orthophosphates (Pi). Organophosphates 97-114 alkaline phosphatase, biomineralization associated Homo sapiens 71-77 30682622-14 2019 Finally, our results imply the role of Gstr1 in metabolism of xenobiotics and protection of fish against deleterious environmental contaminants such as organophosphate insecticides and pharmaceuticals. Organophosphates 152-167 glutathione S-transferase rho Danio rerio 39-44 30499084-0 2019 A low GLP-1 response among patients treated for acute organophosphate and carbamate poisoning: a comparative cross-sectional study from an agrarian region of Sri Lanka. Organophosphates 54-69 glucagon like peptide 1 receptor Homo sapiens 6-11 29322868-0 2019 In silico approaches to evaluate the molecular properties of organophosphate compounds to inhibit acetylcholinesterase activity in housefly. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 30515700-0 2019 Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. Organophosphates 50-65 coagulation factor II Mus musculus 0-8 30499458-0 2019 Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides. Organophosphates 107-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 30499458-2 2019 Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. Organophosphates 241-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 30499458-2 2019 Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. Organophosphates 241-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 30499084-8 2019 The findings of the study allude towards attenuation of GLP-1 response amongst patients after acute organophosphate and carbamate poisoning. Organophosphates 100-115 glucagon like peptide 1 receptor Homo sapiens 56-61 30218924-5 2018 The PtPd@NCS nanocomposites were used as an electrode material to prepare acetylcholinesterase (AChE) biosensors for detecting organophosphate pesticides. Organophosphates 127-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30027640-11 2019 These studies indicate that K-27 can be considered a very promising broad-spectrum prophylactic agent in case of imminent organophosphate exposure, which may be related to its AChE reactivating activity rather than its AChE inhibition. Organophosphates 122-137 keratin 27 Homo sapiens 28-32 30458229-1 2019 Acute organophosphate (OP) poisoning induces well-known signs of toxicosis related to acetylcholinesterase (AChE) inhibition. Organophosphates 6-21 acetylcholinesterase Rattus norvegicus 86-106 30458229-1 2019 Acute organophosphate (OP) poisoning induces well-known signs of toxicosis related to acetylcholinesterase (AChE) inhibition. Organophosphates 6-21 acetylcholinesterase Rattus norvegicus 108-112 30538207-2 2018 Of practical importance, BChE is a promising therapeutic candidate for intoxication by organophosphate nerve agents and insecticides, and for detoxification of addictive substances. Organophosphates 87-102 butyrylcholinesterase Homo sapiens 25-29 30359673-0 2019 Paraoxonase-1 genetic polymorphisms in organophosphate metabolism. Organophosphates 39-54 paraoxonase 1 Homo sapiens 0-13 30462502-1 2018 Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human acetylcholinesterase (hAChE) was observed to be stereospecific. Organophosphates 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 30462502-1 2018 Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human acetylcholinesterase (hAChE) was observed to be stereospecific. Organophosphates 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 30218924-5 2018 The PtPd@NCS nanocomposites were used as an electrode material to prepare acetylcholinesterase (AChE) biosensors for detecting organophosphate pesticides. Organophosphates 127-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 30218924-8 2018 The AChE biosensor was also applied in real samples for detecting organophosphate pesticides and exhibited acceptable recovery. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30496567-1 2018 The nerve agents are extremely toxic organophosphates which lead to massive inhibition of acetylcholinesterase (AChE) in both the central and peripheral nervous systems. Organophosphates 37-53 acetylcholinesterase Rattus norvegicus 90-110 30563111-2 2018 Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Organophosphates 162-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 30265992-0 2018 Design, synthesis and evaluation of new classes of nonquaternary reactivators for acetylcholinesterase inhibited by organophosphates. Organophosphates 116-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 30172926-0 2018 PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure. Organophosphates 82-97 paraoxonase 1 Homo sapiens 0-4 30172926-1 2018 PON1 is a multifunctional enzyme involved in oxidative stress and detoxification of some organophosphate (OP) pesticides. Organophosphates 89-104 paraoxonase 1 Homo sapiens 0-4 30172521-2 2018 Dichlorvos (DDVP), as one of typical organophosphate pesticide, could be hydrolyzed by ALP. Organophosphates 37-52 alkaline phosphatase, placental Homo sapiens 87-90 30291936-0 2018 The organophosphate pesticide methamidophos opens the blood-testis barrier and covalently binds to ZO-2 in mice. Organophosphates 4-19 tight junction protein 2 Mus musculus 99-103 30368112-1 2018 Acetylcholinesterase-1 (AChE1) is a vital enzyme involved in neurotransmission and represents an attractive insecticide-target for organophosphates and carbamates in Plutella xylostella (Linneaus), an important pest of cruciferous crops worldwide. Organophosphates 131-147 acetylcholinesterase-like Plutella xylostella 0-22 30368112-1 2018 Acetylcholinesterase-1 (AChE1) is a vital enzyme involved in neurotransmission and represents an attractive insecticide-target for organophosphates and carbamates in Plutella xylostella (Linneaus), an important pest of cruciferous crops worldwide. Organophosphates 131-147 acetylcholinesterase-like Plutella xylostella 24-29 30424813-1 2018 BACKGROUND: Acute cholinesterase inhibitor (CI) poisoning, including organophosphate and carbamate poisoning, is a crucial problem in developing countries. Organophosphates 69-84 butyrylcholinesterase Homo sapiens 18-32 32254700-0 2018 Light-driven self-powered biosensor for ultrasensitive organophosphate pesticide detection via integration of the conjugated polymer-sensitized CdS and enzyme inhibition strategy. Organophosphates 55-70 CDP-diacylglycerol synthase 1 Homo sapiens 144-147 30443011-1 2018 Previously, we found an unclassified glutathione S-transferase 2 (bmGSTu2) in the silkworm Bombyx mori that conjugates glutathione to 1-chloro-2,4-dinitrobenzene and also metabolises diazinon, an organophosphate insecticide. Organophosphates 196-211 glutathione S-transferase sigma 1 Bombyx mori 37-64 30443011-1 2018 Previously, we found an unclassified glutathione S-transferase 2 (bmGSTu2) in the silkworm Bombyx mori that conjugates glutathione to 1-chloro-2,4-dinitrobenzene and also metabolises diazinon, an organophosphate insecticide. Organophosphates 196-211 GSTu2 Bombyx mori 66-73 30443011-5 2018 bmGSTu2 gene disruption resulted in a decrease in median lethal dose values to an organophosphate insecticide and a decrease in acetylcholine levels in silkworms. Organophosphates 82-97 GSTu2 Bombyx mori 0-7 30443011-6 2018 Taken together, these results indicate that bmGSTu2 could metabolise an organophosphate insecticide. Organophosphates 72-87 GSTu2 Bombyx mori 44-51 30443011-7 2018 Thus, this study provides insights into the physiological role of bmGSTu2 in silkworms, detoxification of organophosphate insecticides, and drug targets for the development of a novel insecticide. Organophosphates 106-121 GSTu2 Bombyx mori 66-73 28497326-1 2018 Cholinesterase inhibitor pesticides, mainly organophosphates and carbamates, are commonly used in Egypt. Organophosphates 44-60 butyrylcholinesterase Homo sapiens 0-14 30345360-1 2018 Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. Organophosphates 0-15 acetylcholinesterase Rattus norvegicus 41-61 30345360-1 2018 Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. Organophosphates 0-15 acetylcholinesterase Rattus norvegicus 63-67 30713772-2 2018 Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Organophosphates 98-113 butyrylcholinesterase Mus musculus 37-58 30192517-7 2018 It is also versatile for the detection of other organophosphate or carbamate pesticides, which have the inhibition ability toward AChE. Organophosphates 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 30713772-3 2018 Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. Organophosphates 117-132 butyrylcholinesterase Mus musculus 76-97 30713772-3 2018 Here, we present the results of a study on the effectiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. Organophosphates 117-132 butyrylcholinesterase Mus musculus 99-103 29301411-2 2018 In this research, the interaction of diazinon, as a toxic organophosphate, with HSA was investigated. Organophosphates 58-73 albumin Homo sapiens 80-83 29730553-0 2018 Exploration of solvent responsive Cr3+-Schiff base conjugates formonitoring Cr3+ ions and organophosphates: Fabrication of spot-testingdevices. Organophosphates 90-106 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 34-37 29859868-0 2018 Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events. Organophosphates 0-15 signal transducer and activator of transcription 1 Homo sapiens 47-52 30144465-9 2018 The purpose of this review is thus to: 1) describe the important uses of organophosphate (OP)-based compounds worldwide, 2) provide an overview of the various risks and toxicology associated with OP exposure, particularly long-term neurologic and psychiatric symptoms, 3) discuss mechanisms of OP toxicity beyond cholinesterase inhibition, 4) review potential therapeutic strategies to reverse the acute toxicity and long term deleterious effects of OPs. Organophosphates 73-88 butyrylcholinesterase Homo sapiens 313-327 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30200437-3 2018 The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse. Organophosphates 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 29730553-6 2018 Besides, the SB Cr3+ conjugates are also able to quantify organophosphate neurotoxins; i.e. diethyl chlorophosphate (with LOD 4.1 nM) and diethyl cyanophosphonate (with LOD 3.3 nM) from aqueous solutions. Organophosphates 58-73 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 16-19 29730553-8 2018 Hence, the conjugation of Schiff base and Cr3+ ions can be explored for the recognition, quantification and extraction of Cr3+ ions and detection of organophosphates. Organophosphates 149-165 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 42-45 29754326-12 2018 These results suggest that GmHAD1, an acid phosphatase gene, improved the utilization of organic phosphate by soybean and Arabidopsis plants. Organophosphates 89-106 LOC547457 Glycine max 38-54 29516527-1 2018 Despite the main mechanism of organophosphate (OP) toxicity through inhibition of acetylcholinesterase (AChE) being well known over the years, some chronic adverse health effects indicate the involvement of additional pathways. Organophosphates 30-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 29516527-1 2018 Despite the main mechanism of organophosphate (OP) toxicity through inhibition of acetylcholinesterase (AChE) being well known over the years, some chronic adverse health effects indicate the involvement of additional pathways. Organophosphates 30-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 29892419-1 2018 Cholinesterase activity (ChA), the effective biomarker for organophosphate pesticide exposure, is possibly affected by single nucleotide polymorphisms (SNPs) in cell-cycle-related genes. Organophosphates 59-74 butyrylcholinesterase Homo sapiens 0-14 29848955-1 2018 Cholinesterase inhibitors are widely used as pesticides in agriculture, but also form a group of organophosphates known as nerve chemical warfare agents. Organophosphates 97-113 butyrylcholinesterase Homo sapiens 0-14 29230717-0 2018 Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis. Organophosphates 65-80 peptidylglycine alpha-amidating monooxygenase Homo sapiens 50-53 29736246-0 2018 Effects of magnesium chloride on in vitro cholinesterase and ATPase poisoning by organophosphate (chlorpyrifos). Organophosphates 81-96 dynein axonemal heavy chain 8 Homo sapiens 61-67 28887667-0 2018 APE1 modulates cellular responses to organophosphate pesticide-induced oxidative damage in non-small cell lung carcinoma A549 cells. Organophosphates 37-52 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 0-4 29881411-4 2018 We investigated the effect of Diazinon (DZN), an organophosphate, on StAR mRNA expression by Sybergreen Real Time-PCR in a time-dependent manner in luteal phase. Organophosphates 49-64 steroidogenic acute regulatory protein Rattus norvegicus 69-73 29404699-2 2018 One of the proteins constituting HDL particles is paraoxonase-1 (PON1), an enzyme able to hydrolyze aryl esters, lactones, and organophosphates. Organophosphates 127-143 paraoxonase 1 Homo sapiens 50-63 29404699-2 2018 One of the proteins constituting HDL particles is paraoxonase-1 (PON1), an enzyme able to hydrolyze aryl esters, lactones, and organophosphates. Organophosphates 127-143 paraoxonase 1 Homo sapiens 65-69 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Organophosphates 135-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Organophosphates 135-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Organophosphates 135-150 butyrylcholinesterase Homo sapiens 61-82 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Organophosphates 135-150 butyrylcholinesterase Homo sapiens 84-88 29299760-0 2018 Correction to: Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis. Organophosphates 80-95 peptidylglycine alpha-amidating monooxygenase Homo sapiens 65-68 29258877-1 2018 Organophosphate pesticide diazinon is a specific inhibitor of acetylcholinesterase (AChE), which is a common neurotoxicity biomarker in environmental studies. Organophosphates 0-15 acetylcholinesterase 2 Apis mellifera 84-88 29112739-0 2018 Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERalpha. Organophosphates 0-15 estrogen receptor 1 (alpha) Mus musculus 147-154 28930602-2 2018 Organophosphate (OP) acaricides target acetylcholinesterase (AChE) critical to tick central nervous system function. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 29243208-1 2018 The inhibition of cholinesterase (ChE) activity has been used as a biomarker of exposure to organophosphate and carbamate insecticides. Organophosphates 92-107 cholinesterase Chelonia mydas 18-32 29243208-1 2018 The inhibition of cholinesterase (ChE) activity has been used as a biomarker of exposure to organophosphate and carbamate insecticides. Organophosphates 92-107 cholinesterase Chelonia mydas 34-37 29895246-9 2018 Gender differences in the pharmacological effects result in higher sensitivity to the toxic effects of organophosphate cholinesterase inhibitors in males. Organophosphates 103-118 butyrylcholinesterase Homo sapiens 119-133 29272792-0 2018 In-silico and in-vitro evaluation of human acetylcholinesterase inhibition by organophosphates. Organophosphates 78-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-192 29434782-8 2018 The results showed that the expression of OX62, MHC-II and CD86 in bone marrow DCs is enhanced and the cellular immune function is enhanced after organophosphate poisoning. Organophosphates 146-161 CD86 molecule Rattus norvegicus 59-63 29026987-4 2018 AChE is a physiological marker of organophosphate/carbamate pesticide exposures that may take up to 3 months to normalize after its inhibition. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 28927721-4 2018 Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, diphenyl ethers, organochlorines, and organophosphates. Organophosphates 236-252 nuclear receptor subfamily 1 group I member 3 Homo sapiens 23-26 28930602-2 2018 Organophosphate (OP) acaricides target acetylcholinesterase (AChE) critical to tick central nervous system function. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 28929747-1 2017 Carboxylesterase (CBE)-mediated metabolic resistance to organophosphate and carbamate insecticides is a major problem for the control of insect disease vectors, such as the mosquito. Organophosphates 56-71 esterase 6 Culex quinquefasciatus 0-16 29362639-2 2017 MATERIAL AND METHODS: In a group of 35 acute poisoned patients by organophosphate compounds has led to inhibition of AchE. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 28929747-1 2017 Carboxylesterase (CBE)-mediated metabolic resistance to organophosphate and carbamate insecticides is a major problem for the control of insect disease vectors, such as the mosquito. Organophosphates 56-71 esterase 6 Culex quinquefasciatus 18-21 28929747-5 2017 Lysine methylation was used to obtain the crystal structure of Cqestbeta21, which adopts a canonical alpha/beta-hydrolase fold that has high similarity to the target of organophosphate and carbamate insecticides, acetylcholinesterase. Organophosphates 169-184 acetylcholinesterase Culex quinquefasciatus 213-233 28991135-5 2017 CONCLUSION: The negative outcomes described above suggest that exposure to organophosphates or other agents normally detoxified by PON1 and BuChE may not have contributed significantly to neurologic components of Gulf War Illness. Organophosphates 75-91 paraoxonase 1 Homo sapiens 131-135 28665493-1 2017 Paraoxonase-1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Organophosphates 27-42 paraoxonase 1 Homo sapiens 0-13 28665493-1 2017 Paraoxonase-1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Organophosphates 27-42 paraoxonase 1 Homo sapiens 15-19 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Organophosphates 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Organophosphates 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Organophosphates 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Organophosphates 160-175 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 357-361 28845507-7 2017 Cholinesterase inhibiting insecticides (organophosphates and N-methylcarbamates), triazole fungicides, triazine herbicides, and pyrethroid insecticides are overrepresented in the synergistic mixtures identified so far. Organophosphates 40-56 butyrylcholinesterase Homo sapiens 0-14 28843102-5 2017 In the group exposed to organophosphates, the activity of acetylcholinesterase, butyrylcholinesterase and total cholinesterase was lower by 63.8%, 12.8%, and 14.8%, respectively, and 92.6% of the group had dialkyl phosphates present in their urine. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 28843102-5 2017 In the group exposed to organophosphates, the activity of acetylcholinesterase, butyrylcholinesterase and total cholinesterase was lower by 63.8%, 12.8%, and 14.8%, respectively, and 92.6% of the group had dialkyl phosphates present in their urine. Organophosphates 24-40 butyrylcholinesterase Homo sapiens 80-126 28991135-5 2017 CONCLUSION: The negative outcomes described above suggest that exposure to organophosphates or other agents normally detoxified by PON1 and BuChE may not have contributed significantly to neurologic components of Gulf War Illness. Organophosphates 75-91 butyrylcholinesterase Homo sapiens 140-145 28601397-1 2017 Activation of PI3K/Akt signaling, leading to upregulation of nitric oxide synthase II (NOS II)/peroxynitrite cascade in the rostral ventrolateral medulla (RVLM), the brain stem site that maintains blood pressure and sympathetic vasomotor tone, underpins cardiovascular depression induced by the organophosphate pesticide mevinphos. Organophosphates 295-310 AKT serine/threonine kinase 1 Rattus norvegicus 19-22 28820005-1 2017 Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity. Organophosphates 39-54 fatty-acid amide hydrolase-like Rattus norvegicus 134-138 28820005-1 2017 Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity. Organophosphates 39-54 monoglyceride lipase Rattus norvegicus 208-231 28820005-1 2017 Repeated developmental exposure to the organophosphate (OP) insecticide chlorpyrifos (CPF) inhibits brain fatty acid amide hydrolase (FAAH) activity at low levels, whereas at higher levels, it inhibits brain monoacylglycerol lipase (MAGL) activity. Organophosphates 39-54 monoglyceride lipase Rattus norvegicus 233-237 28787189-5 2017 Computerized-assisted semen analysis (CASA) was performed, and the enzyme activity was measured based on the ability of ATPase to release organic phosphate from ATP as a substrate. Organophosphates 138-155 dynein axonemal heavy chain 8 Homo sapiens 120-126 28595929-0 2017 Solvent-dependent binding interactions of the organophosphate pesticide, chlorpyrifos (CPF), and its metabolite, 3,5,6-trichloro-2-pyridinol (TCPy), with Bovine Serum Albumin (BSA): A comparative fluorescence quenching analysis. Organophosphates 46-61 albumin Homo sapiens 161-174 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 28465191-10 2017 The presented results might be useful in routine clinical practice where the monitoring of blood AChE and plasma BChE activity is crucial for prognosis and diagnosis of organophosphate poisoning, in occupational medicine and in relevant mass casualty scenarios. Organophosphates 169-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 28465191-10 2017 The presented results might be useful in routine clinical practice where the monitoring of blood AChE and plasma BChE activity is crucial for prognosis and diagnosis of organophosphate poisoning, in occupational medicine and in relevant mass casualty scenarios. Organophosphates 169-184 butyrylcholinesterase Homo sapiens 113-117 28161867-1 2017 Human paraoxonase 1 (h-PON1) is a ~45-kDa serum enzyme that can hydrolyze a variety of substrates, including organophosphate (OP) compounds. Organophosphates 109-124 paraoxonase 1 Homo sapiens 6-19 28161867-1 2017 Human paraoxonase 1 (h-PON1) is a ~45-kDa serum enzyme that can hydrolyze a variety of substrates, including organophosphate (OP) compounds. Organophosphates 109-124 paraoxonase 1 Homo sapiens 23-27 28894590-0 2017 TRPA1 channel mediates organophosphate-induced delayed neuropathy. Organophosphates 23-38 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5 28718803-0 2017 Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates. Organophosphates 75-91 albumin Homo sapiens 0-13 29225470-0 2017 Plasma Cholinesterase Levels of Nepalese Farmers Following Exposure to Organophosphate Pesticides. Organophosphates 71-86 butyrylcholinesterase Homo sapiens 7-21 29225470-2 2017 Thus, the aim of this study was to compare plasma cholinesterase (PChE) enzyme activity before and after exposure to organophosphate pesticides in a real-life setting. Organophosphates 117-132 butyrylcholinesterase Homo sapiens 50-64 27262357-0 2017 Cell cycle activation in p21 dependent pathway: An alternative mechanism of organophosphate induced dopaminergic neurodegeneration. Organophosphates 76-91 KRAS proto-oncogene, GTPase Rattus norvegicus 25-28 28467056-0 2017 Easy-Preparable Butyrylcholinesterase/Microgel Construct for Facilitated Organophosphate Biosensing. Organophosphates 73-88 butyrylcholinesterase Homo sapiens 16-37 27125569-1 2017 Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream. Organophosphates 126-142 butyrylcholinesterase Homo sapiens 0-22 28369648-3 2017 Cytochrome P450 enzymes are expressed at a relatively high level in astrocytes and may play a critical role in the biotransformation of endogenous or exogenous compounds, including chlorpyrifos, an organophosphate insecticide that affects the central nervous system. Organophosphates 198-213 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 28206686-1 2017 Neuropathy target esterase (NTE) or patatin-like phospholipase domain containing 6 (PNPLA6) was first linked with a neuropathy occurring after organophosphate poisoning and was later also found to cause complex syndromes when mutated, which can include mental retardation, spastic paraplegia, ataxia, and blindness. Organophosphates 143-158 patatin like phospholipase domain containing 6 Homo sapiens 0-26 28206686-1 2017 Neuropathy target esterase (NTE) or patatin-like phospholipase domain containing 6 (PNPLA6) was first linked with a neuropathy occurring after organophosphate poisoning and was later also found to cause complex syndromes when mutated, which can include mental retardation, spastic paraplegia, ataxia, and blindness. Organophosphates 143-158 patatin like phospholipase domain containing 6 Homo sapiens 28-31 28206686-1 2017 Neuropathy target esterase (NTE) or patatin-like phospholipase domain containing 6 (PNPLA6) was first linked with a neuropathy occurring after organophosphate poisoning and was later also found to cause complex syndromes when mutated, which can include mental retardation, spastic paraplegia, ataxia, and blindness. Organophosphates 143-158 patatin like phospholipase domain containing 6 Homo sapiens 84-90 27125569-1 2017 Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream. Organophosphates 126-142 butyrylcholinesterase Homo sapiens 24-28 27125569-1 2017 Butyryl cholinesterase (BChE) has been seen as a key enzyme in the search for new strategies in the treatment of poisoning by organophosphates (OPs), since human BChE (HssBChE), complexed with the appropriate oxime, can be a suitable scavenger and deactivator for OPs in the blood stream. Organophosphates 126-142 butyrylcholinesterase Homo sapiens 162-166 27967267-5 2017 Areas covered: This article covers recent advances in the development of acetylcholinesterase modulators, including both inhibitors of acetylcholinesterase for the efforts in development of new chemical entities for treatment of AD, as well as re-activators for resurrection of organophosphate bound acetylcholinesterase. Organophosphates 278-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 28188819-1 2017 BACKGROUND: Exposures to cholinesterase inhibitor pesticides (e.g. organophosphates) have been associated with children"s neurobehavioral alterations, including attention deficit and impulsivity. Organophosphates 67-83 butyrylcholinesterase Homo sapiens 25-39 28235599-1 2017 Organophosphate pesticides elicit developmental neurotoxicity through mechanisms over and above their shared property as cholinesterase inhibitors. Organophosphates 0-15 butyrylcholinesterase Rattus norvegicus 121-135 28300621-1 2017 We hypothesized that expression of mutant Huntingtin (HTT) would modulate the neurotoxicity of the commonly used organophosphate insecticide, chlorpyrifos (CPF), revealing cellular mechanisms underlying neurodegeneration. Organophosphates 113-128 huntingtin Mus musculus 42-52 28300621-1 2017 We hypothesized that expression of mutant Huntingtin (HTT) would modulate the neurotoxicity of the commonly used organophosphate insecticide, chlorpyrifos (CPF), revealing cellular mechanisms underlying neurodegeneration. Organophosphates 113-128 huntingtin Mus musculus 54-57 28061415-0 2017 An enantiomer-based virtual screening approach: Discovery of chiral organophosphates as acetyl cholinesterase inhibitors. Organophosphates 68-84 butyrylcholinesterase Homo sapiens 95-109 27967267-9 2017 New small molecule reactivators of organophosphate-inhibited AChE have also been disclosed, which focused on the design of neutral ligands with improved pharmaceutical properties and blood-brain barrier (BBB) penetration. Organophosphates 35-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 27939611-1 2017 Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to irreversible inhibition of neuropathy target esterase (NTE) and impairment of neurite outgrowth. Organophosphates 83-98 patatin like phospholipase domain containing 6 Homo sapiens 182-208 27288108-3 2017 The ortho-isomer, ToCP and its metabolite CBDP are also known to affect neuropathy target esterase (NTE) leading to organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 116-131 patatin like phospholipase domain containing 6 Homo sapiens 72-98 27288108-3 2017 The ortho-isomer, ToCP and its metabolite CBDP are also known to affect neuropathy target esterase (NTE) leading to organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 116-131 patatin like phospholipase domain containing 6 Homo sapiens 100-103 28174098-2 2017 Recent literature has reported that human bone marrow-derived MSCs express active acetylcholinesterase (AChE) and that disruption of AChE activity by organophosphate (OP) chemicals decreases the ability of MSCs to differentiate into osteoblasts. Organophosphates 150-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 27939611-1 2017 Some organophosphorus compounds (OPs) induce a neurodegenerative disorder known as organophosphate-induced delayed neuropathy (OPIDN), which is related to irreversible inhibition of neuropathy target esterase (NTE) and impairment of neurite outgrowth. Organophosphates 83-98 patatin like phospholipase domain containing 6 Homo sapiens 210-213 27769869-1 2016 Organophosphates affect brain function through a variety of mechanisms beyond their shared role as cholinesterase inhibitors. Organophosphates 0-16 butyrylcholinesterase Rattus norvegicus 99-113 29430251-1 2017 Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, hydrolyzes several organophosphate pesticides and oxidized lipids. Organophosphates 99-114 paraoxonase 1 Homo sapiens 0-13 29430251-1 2017 Paraoxonase 1 (PON1), a high-density lipoprotein-associated antioxidant enzyme, hydrolyzes several organophosphate pesticides and oxidized lipids. Organophosphates 99-114 paraoxonase 1 Homo sapiens 15-19 28646835-4 2017 Objective: This study aims to determine the association between blood cholinesterase activity and organophosphate pesticide residues on chili farmer"s hands and their adverse health effects. Organophosphates 98-113 butyrylcholinesterase Homo sapiens 70-84 27582056-1 2016 Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many failures in living organism and ultimately in death. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 27582056-1 2016 Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many failures in living organism and ultimately in death. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 26948828-0 2017 Downregulation of human paraoxonase 1 (PON1) by organophosphate pesticides in HepG2 cells. Organophosphates 48-63 paraoxonase 1 Homo sapiens 24-37 26948828-0 2017 Downregulation of human paraoxonase 1 (PON1) by organophosphate pesticides in HepG2 cells. Organophosphates 48-63 paraoxonase 1 Homo sapiens 39-43 28026940-1 2017 Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and carbonates. Organophosphates 125-141 paraoxonase 1 Homo sapiens 21-25 27799040-1 2017 BACKGROUND: Reversible cholinesterase inhibitors, when given prophylactically before exposure to organophosphates, are able to decrease organophosphate-induced mortality. Organophosphates 97-113 butyrylcholinesterase Rattus norvegicus 23-37 27799040-1 2017 BACKGROUND: Reversible cholinesterase inhibitors, when given prophylactically before exposure to organophosphates, are able to decrease organophosphate-induced mortality. Organophosphates 97-112 butyrylcholinesterase Rattus norvegicus 23-37 27799040-9 2017 CONCLUSION: These data indicate that K-27 can be considered a very efficacious prophylactic agent for organophosphate exposure. Organophosphates 102-117 keratin 27 Rattus norvegicus 37-41 27693445-1 2016 Pre-treatment with reversible acetylcholinesterase (AChE) inhibitors is an effective strategy for reducing lethality following organophosphate nerve agent exposure. Organophosphates 127-142 ACE-1 Oryctolagus cuniculus 30-50 27693445-1 2016 Pre-treatment with reversible acetylcholinesterase (AChE) inhibitors is an effective strategy for reducing lethality following organophosphate nerve agent exposure. Organophosphates 127-142 ACE-1 Oryctolagus cuniculus 52-56 27387540-1 2016 Pyridinium oximes are strong nucleophiles and many are effective reactivators of organophosphate-inhibited cholinesterase (ChE). Organophosphates 81-96 butyrylcholinesterase Rattus norvegicus 107-121 27129421-1 2016 The antidotal treatment of organophosphates (OP) nerve agents (NA) poisoning is based on anticholinergics (e.g. atropine) combined with oxime reactivators (e.g. 2PAM) of acetylcholinesterase (AChE). Organophosphates 27-43 acetylcholinesterase Rattus norvegicus 170-190 27387540-1 2016 Pyridinium oximes are strong nucleophiles and many are effective reactivators of organophosphate-inhibited cholinesterase (ChE). Organophosphates 81-96 butyrylcholinesterase Rattus norvegicus 123-126 27129421-1 2016 The antidotal treatment of organophosphates (OP) nerve agents (NA) poisoning is based on anticholinergics (e.g. atropine) combined with oxime reactivators (e.g. 2PAM) of acetylcholinesterase (AChE). Organophosphates 27-43 acetylcholinesterase Rattus norvegicus 192-196 27604478-4 2016 Moreover, the binding of HupNIR2 is affected when AChE is inhibited with toxic molecules such as organophosphates. Organophosphates 97-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 27551891-1 2016 The organophosphate O-(2-fluoroethyl)-O-(p-nitrophenyl) methyphosphonate 1 is the first-in-class, fluorine-18 radiolabeled organophosphate inhibitor ([18F]1) of acetylcholinesterase (AChE). Organophosphates 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 27551891-1 2016 The organophosphate O-(2-fluoroethyl)-O-(p-nitrophenyl) methyphosphonate 1 is the first-in-class, fluorine-18 radiolabeled organophosphate inhibitor ([18F]1) of acetylcholinesterase (AChE). Organophosphates 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 27062889-3 2016 Discovered first as an esterase that hydrolyze organophosphates, human paraoxonase-1 is bound to high-density lipoprotein and inhibits the oxidation of lipoproteins and reduces the degree of inflammation, hence it is considered to act against atherosclerosis. Organophosphates 47-63 paraoxonase 1 Homo sapiens 71-84 27289207-1 2016 Chlorpyrifos-methyl (CLP-m) is a widely used organophosphate insecticide that can accumulate in soil and become toxic to humans. Organophosphates 45-60 calmodulin like 3 Homo sapiens 21-24 27402326-1 2016 The main mechanism of toxicity of organophosphate (OP) and carbamate (CB) insecticides is their irreversible binding and inhibition of acetylcholinestrase (AChE), encoded by ace1 (acetylcholinestrase gene 1), leading to eventual death of insects. Organophosphates 34-49 acetylcholinesterase type 1 Bombyx mori 174-178 25982292-1 2016 Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. Organophosphates 145-161 paraoxonase 1 Homo sapiens 12-25 26937779-5 2016 Stability behavior for organophosphates agreed with the proposed reaction mechanism responsible for acetylcholinesterase inhibition. Organophosphates 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 27371941-0 2016 Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 27131877-0 2016 Refolded Recombinant Human Paraoxonase 1 Variant Exhibits Prophylactic Activity Against Organophosphate Poisoning. Organophosphates 88-103 paraoxonase 1 Homo sapiens 27-40 27191504-1 2016 Irreversible inhibition of the essential nervous system enzyme acetylcholinesterase by organophosphate nerve agents and pesticides may quickly lead to death. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 27191504-3 2016 The current lack of published structural data specific to human acetylcholinesterase organophosphate-inhibited and oxime-bound states hinders development of effective medical treatments. Organophosphates 85-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 27191504-4 2016 We have solved structures of human acetylcholinesterase in different states in complex with the organophosphate insecticide, paraoxon, and oximes. Organophosphates 96-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27191504-6 2016 This appears characteristic of acetylcholinesterase inhibition by organophosphate insecticides but not nerve agents. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 27260432-0 2016 A sensitive acetylcholinesterase biosensor based on gold nanorods modified electrode for detection of organophosphate pesticide. Organophosphates 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 27260432-1 2016 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on gold nanorods (AuNRs), was developed for the detection of organophosphate pesticide. Organophosphates 131-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 27260432-1 2016 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on gold nanorods (AuNRs), was developed for the detection of organophosphate pesticide. Organophosphates 131-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 27260432-3 2016 The AChE/AuNRs/GCE biosensor was fabricated on basis of the inhibition of AChE activity by organophosphate pesticide. Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 27260432-3 2016 The AChE/AuNRs/GCE biosensor was fabricated on basis of the inhibition of AChE activity by organophosphate pesticide. Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 27371941-1 2016 Acetylcholinesterase (AChE; EC 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (OP) pesticide intoxication. Organophosphates 155-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27371941-1 2016 Acetylcholinesterase (AChE; EC 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (OP) pesticide intoxication. Organophosphates 155-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27087156-5 2016 Human serum PON1 can break down organophosphate before binding to ChE. Organophosphates 32-47 paraoxonase 1 Homo sapiens 12-16 25982292-1 2016 Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. Organophosphates 145-161 paraoxonase 1 Homo sapiens 27-31 27177985-1 2016 As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE), the majority of studies on these have been directed towards their synthesis and testing. Organophosphates 59-74 acetylcholinesterase Rattus norvegicus 90-110 27440377-3 2016 The enzyme (bmGSTu2) conjugates glutathione to 1-chloro-2,4-dinitrobenzene, as well as metabolizing diazinon, one of the organophosphate insecticides. Organophosphates 121-136 GSTu2 Bombyx mori 12-19 28265445-1 2016 BACKGROUND: Paraoxonase-1, an organophosphorous-hydrolyzing enzyme, was shown to provide protection against organophosphates poisoning in vivo. Organophosphates 108-124 paraoxonase 1 Rattus norvegicus 12-25 27648190-1 2016 INTRODUCTION: Malathion is one of organophosphate poisons (OPPs) that inhibit cholinesterase activity and induce oxidative stress in target organs, such as the reproductive system. Organophosphates 34-49 butyrylcholinesterase Rattus norvegicus 78-92 27065443-4 2016 Contaminant discharges of organophosphate pesticides into the sea were calculated in about 545.36kgyear(-1) showing that this river should be consider as one of the main contribution sources of organophosphate pesticides to the Tyrrhenian Sea. Organophosphates 26-41 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 62-65 27065443-4 2016 Contaminant discharges of organophosphate pesticides into the sea were calculated in about 545.36kgyear(-1) showing that this river should be consider as one of the main contribution sources of organophosphate pesticides to the Tyrrhenian Sea. Organophosphates 194-209 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 62-65 27396356-1 2016 BACKGROUND: Current therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase. Organophosphates 34-49 peptidylglycine alpha-amidating monooxygenase Canis lupus familiaris 117-120 27396356-1 2016 BACKGROUND: Current therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase. Organophosphates 34-49 acetylcholinesterase Canis lupus familiaris 150-170 27177985-1 2016 As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE), the majority of studies on these have been directed towards their synthesis and testing. Organophosphates 59-74 acetylcholinesterase Rattus norvegicus 112-116 27153507-1 2016 Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood-brain barrier and therefore cannot restore brain ChE activity in vivo. Organophosphates 31-46 butyrylcholinesterase Rattus norvegicus 57-71 27364165-2 2016 Prior studies from our laboratory and others have demonstrated that the combinatorial effect of two factors-reduced expression of reelin protein and prenatal exposure to the organophosphate pesticide chlorpyrifos oxon-gives rise to acute biochemical effects and to morphological and behavioral phenotypes in adolescent and young adult mice. Organophosphates 174-189 reelin Mus musculus 130-136 28959576-1 2016 Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetylcholinesterase enzyme (AChE). Organophosphates 21-36 acetylcholinesterase Rattus norvegicus 99-126 28959576-1 2016 Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetylcholinesterase enzyme (AChE). Organophosphates 21-36 acetylcholinesterase Rattus norvegicus 128-132 27153507-1 2016 Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood-brain barrier and therefore cannot restore brain ChE activity in vivo. Organophosphates 31-46 butyrylcholinesterase Rattus norvegicus 73-76 27101948-0 2016 Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase. Organophosphates 57-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 27101948-1 2016 Organophosphate (OP)-based pesticides and nerve agents are highly toxic compounds which interrupt the catalytic mechanism of acetylcholinesterase (AChE) by phosphorylating the hydroxyl moiety of serine residue. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 27101948-1 2016 Organophosphate (OP)-based pesticides and nerve agents are highly toxic compounds which interrupt the catalytic mechanism of acetylcholinesterase (AChE) by phosphorylating the hydroxyl moiety of serine residue. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 27063423-1 2016 Butyrylcholinesterase (BChE) is the most promising bioscavenger candidate to treat or prevent organophosphate (OP) poisoning. Organophosphates 94-109 butyrylcholinesterase Homo sapiens 0-21 27063423-1 2016 Butyrylcholinesterase (BChE) is the most promising bioscavenger candidate to treat or prevent organophosphate (OP) poisoning. Organophosphates 94-109 butyrylcholinesterase Homo sapiens 23-27 27079411-4 2016 We present a clinical case with hyperglycemic ketoacidosis due to the contact with organophosphate; we had to use a continuous infusion of insulin to control the metabolic disorder without repercussions after the girl came home. Organophosphates 83-98 insulin Homo sapiens 139-146 27012934-2 2016 To study the interactions of a biologic in the lung, we chose butyrylcholinesterase (BuChE) as our model enzyme, which has application for use as a bioscavenger protecting against organophosphate exposure or for use with pseudocholinesterase deficient patients. Organophosphates 180-195 butyrylcholinesterase Homo sapiens 62-83 26894816-0 2016 Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka. Organophosphates 49-64 sorcin Homo sapiens 95-98 27018022-5 2016 However, given the transcriptional changes that occur in nervous system genes in response to OPFRs and CPF, as well as the altered enzyme activity of AChE and its mRNA level, the underlying mechanisms for neurotoxicity among these organophosphate chemicals might be varied. Organophosphates 231-246 acetylcholinesterase Danio rerio 150-154 30090408-3 2016 Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication. Organophosphates 108-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 27212759-3 2016 Fresh frozen plasma [FFP] a source of serum cholinesterase act as bio-scavenger to neutralise organophosphate toxins to improve the patients out come. Organophosphates 94-109 butyrylcholinesterase Homo sapiens 44-58 26953358-1 2016 We developed a new magnetic nanoparticle sandwich-like immunoassay using protein cage nanoparticles (PCN) for signal amplification together with graphite furnace atomic absorption spectrometry (GFAAS) for the quantification of an organophosphorylated acetylcholinesterase adduct (OP-AChE), the biomarker of exposure to organophosphate pesticides (OPs) and nerve agents. Organophosphates 319-334 pericentrin Homo sapiens 101-104 26747974-2 2016 Both oximes are very potent reactivators of organophosphate-inhibited AChE. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 27055524-0 2016 A mechanism-based 3D-QSAR approach for classification and prediction of acetylcholinesterase inhibitory potency of organophosphate and carbamate analogs. Organophosphates 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 25943120-0 2016 Measurement of cholinesterase enzyme activity before and after exposure to organophosphate pesticides in farmers of a suburb region of Mazandaran, a northern province of Iran. Organophosphates 75-90 butyrylcholinesterase Homo sapiens 15-29 26723569-5 2016 OBJECTIVE: to investigate a possible association between genetic polymorphisms of PON1 Q192R, and CYP2D6 G1934A as well as PON1 and pseudo-cholinesterase (PChE) enzyme activity levels and chronic organophosphate exposed patients, and hence, susceptibility for organophosphorus chronic poisoning. Organophosphates 196-211 paraoxonase 1 Homo sapiens 82-86 26723569-14 2016 CONCLUSION: PON1 192RR genotype and CYP2D6 1934A allele were found to be related to the susceptibility to organophosphate chronic toxicity in Egyptians. Organophosphates 106-121 paraoxonase 1 Homo sapiens 12-16 26723569-14 2016 CONCLUSION: PON1 192RR genotype and CYP2D6 1934A allele were found to be related to the susceptibility to organophosphate chronic toxicity in Egyptians. Organophosphates 106-121 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 36-42 26210933-0 2016 Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 26895825-6 2016 Evolved strains acquired a few additional genetic changes besides the trkH, kdpD and arcA mutations, which might increase the scavenging of organophosphates (phnE (+), lapB, and rseP) and the resistance to oxidative (rsxC) and acetic acid stresses (e14(-)/icd (+)). Organophosphates 140-156 arginine deiminase Escherichia coli 85-89 26895825-8 2016 The spread of these mutant strains might give the ancestral strain time to accumulate up to five genetic changes (phnE (+) arcA rsxC crfC e14(-)/icd (+)), which allowed growth on glucose and organophosphates, and provided a long-term survival. Organophosphates 191-207 arginine deiminase Escherichia coli 123-127 26790371-2 2016 This family includes acethylcholinesterase (AChE), carboxylesterase (CES) and butyrylcholinesterase (BChE), which are important targets of organophosphate insecticide (OP) toxicity. Organophosphates 139-154 butyrylcholinesterase Homo sapiens 78-99 26790371-2 2016 This family includes acethylcholinesterase (AChE), carboxylesterase (CES) and butyrylcholinesterase (BChE), which are important targets of organophosphate insecticide (OP) toxicity. Organophosphates 139-154 butyrylcholinesterase Homo sapiens 101-105 26879855-1 2016 Paraoxonase (PON) is a key enzyme in metabolism of living organisms and decreased activity of PON1 was acknowledged as a risk for atherosclerosis and organophosphate toxicity. Organophosphates 150-165 paraoxonase 1 Homo sapiens 0-11 26879855-1 2016 Paraoxonase (PON) is a key enzyme in metabolism of living organisms and decreased activity of PON1 was acknowledged as a risk for atherosclerosis and organophosphate toxicity. Organophosphates 150-165 paraoxonase 1 Homo sapiens 13-16 26879855-1 2016 Paraoxonase (PON) is a key enzyme in metabolism of living organisms and decreased activity of PON1 was acknowledged as a risk for atherosclerosis and organophosphate toxicity. Organophosphates 150-165 paraoxonase 1 Homo sapiens 94-98 26957210-13 2016 At present there are several countries reliant on organophosphates and carbamates for IRS, and increasing incipient resistance is a serious threat that could result in IRS no longer being viable. Organophosphates 50-66 isoleucyl-tRNA synthetase 1 Homo sapiens 86-89 26414738-10 2016 The inhibition of CbE and BChE activities corroborated that these enzymes are fulfilling their role as bioscavengers for organophosphate pesticides, decreasing its concentration and thus protecting AChE activity against inhibition by chlorpyrifos. Organophosphates 121-136 cholinesterase Coturnix japonica 26-30 26549836-0 2016 Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers. Organophosphates 47-62 paraoxonase 1 Homo sapiens 11-24 28959540-1 2016 Organophosphates (OPs) are cholinesterase inhibitors that lead to a characteristic toxidrome of hypersecretion, miosis, dyspnea, respiratory insufficiency, convulsions and, without proper and early antidotal treatment, death. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 27-41 28959540-1 2016 Organophosphates (OPs) are cholinesterase inhibitors that lead to a characteristic toxidrome of hypersecretion, miosis, dyspnea, respiratory insufficiency, convulsions and, without proper and early antidotal treatment, death. Organophosphates 18-21 butyrylcholinesterase Homo sapiens 27-41 26549836-1 2016 OBJECTIVES: Paraoxonase 1 (PON1) in serum detoxifies organophosphate (OP) insecticides by hydrolysis. Organophosphates 53-68 paraoxonase 1 Homo sapiens 12-25 26549836-1 2016 OBJECTIVES: Paraoxonase 1 (PON1) in serum detoxifies organophosphate (OP) insecticides by hydrolysis. Organophosphates 53-68 paraoxonase 1 Homo sapiens 27-31 26434531-2 2015 PON1 acts as an antioxidant preventing lipid oxidation and detoxifies a wide range of substrates, including organophosphate compounds. Organophosphates 108-123 paraoxonase 1 Homo sapiens 0-4 26459445-2 2015 Paper-based platforms, including point-of-care devices and 96-well plates, provided semi-quantitative information regarding the concentration of AchE (a biomarker for organophosphate poisoning). Organophosphates 167-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 26318115-2 2015 Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. Organophosphates 172-188 paraoxonase 1 Homo sapiens 0-13 23625910-0 2015 Effect of paraoxonase 1 192 Q/R polymorphism on paraoxonase and acetylcholinesterase enzyme activities in a Turkish population exposed to organophosphate. Organophosphates 138-153 paraoxonase 1 Homo sapiens 10-23 23625910-0 2015 Effect of paraoxonase 1 192 Q/R polymorphism on paraoxonase and acetylcholinesterase enzyme activities in a Turkish population exposed to organophosphate. Organophosphates 138-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 26239905-0 2015 A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning. Organophosphates 166-181 butyrylcholinesterase Homo sapiens 90-111 26318115-2 2015 Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. Organophosphates 172-188 paraoxonase 1 Homo sapiens 15-19 26318115-2 2015 Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. Organophosphates 172-188 butyrylcholinesterase Homo sapiens 22-43 26318115-2 2015 Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. Organophosphates 172-188 butyrylcholinesterase Homo sapiens 45-49 26318115-2 2015 Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. Organophosphates 172-188 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-70 26318115-9 2015 The adverse genotype combination (unusual BCHE variants, PON1 55MM/-108TT and null genotype for both GSTM1 and GSTT1) potentially conferring a greater genetic risk from exposure to organophosphates was observed in 0.2% of our study population. Organophosphates 181-197 butyrylcholinesterase Homo sapiens 42-46 26318115-9 2015 The adverse genotype combination (unusual BCHE variants, PON1 55MM/-108TT and null genotype for both GSTM1 and GSTT1) potentially conferring a greater genetic risk from exposure to organophosphates was observed in 0.2% of our study population. Organophosphates 181-197 paraoxonase 1 Homo sapiens 57-61 26318115-9 2015 The adverse genotype combination (unusual BCHE variants, PON1 55MM/-108TT and null genotype for both GSTM1 and GSTT1) potentially conferring a greater genetic risk from exposure to organophosphates was observed in 0.2% of our study population. Organophosphates 181-197 glutathione S-transferase mu 1 Homo sapiens 101-106 26318115-9 2015 The adverse genotype combination (unusual BCHE variants, PON1 55MM/-108TT and null genotype for both GSTM1 and GSTT1) potentially conferring a greater genetic risk from exposure to organophosphates was observed in 0.2% of our study population. Organophosphates 181-197 glutathione S-transferase theta 1 Homo sapiens 111-116 26520174-3 2015 The non-target toxicity and resistance problem of organophosphate and carbamate have become of growing concern, which may be due to the fact that they target the ubiquitous catalytic serine residue of acetylcholinesterase (AChE) in mammals, birds, and beneficial insects. Organophosphates 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 26452809-2 2015 Paper-based platforms, including point-of-care devices and 96-well plates, provided semi-quantitative information regarding the concentration of AchE (a biomarker for organophosphate poisoning). Organophosphates 167-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 25491602-0 2015 Geographical distribution and frequencies of organophosphate-resistant Ace alleles and morphometric variations in olive fruit fly populations. Organophosphates 45-60 acetylcholinesterase Bactrocera oleae 71-74 26350723-0 2015 Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. Organophosphates 88-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 26078409-1 2015 The current standard of care for treatment of organophosphate (OP) poisoning includes pretreatment with the weak reversible acetylcholinesterase (AChE) inhibitor pyridostigmine bromide. Organophosphates 46-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 26286433-0 2015 Rational design of paraoxonase 1 (PON1) for the efficient hydrolysis of organophosphates. Organophosphates 72-88 paraoxonase 1 Homo sapiens 19-32 26286433-0 2015 Rational design of paraoxonase 1 (PON1) for the efficient hydrolysis of organophosphates. Organophosphates 72-88 paraoxonase 1 Homo sapiens 34-38 26286433-1 2015 A rational design of paraoxonase 1 based on molecular docking discovered H115W/T332S and I74F/H115W/T332S mutants exhibited a 40-fold increase in catalytic efficiency (kcat/Km) toward the hydrolysis of two toxic and popular organophosphates (diethyl-paraoxon and dimethyl-paraoxon). Organophosphates 224-240 paraoxonase 1 Homo sapiens 21-34 26078409-1 2015 The current standard of care for treatment of organophosphate (OP) poisoning includes pretreatment with the weak reversible acetylcholinesterase (AChE) inhibitor pyridostigmine bromide. Organophosphates 46-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26370177-1 2015 We demonstrate the role of molecular switching of TrkA/p75(NTR) signaling cascade in organophosphate pesticide-Monocrotophos (MCP) induced neurotoxicity in stem cell derived cholinergic neurons and in rat brain. Organophosphates 85-100 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 50-54 25758980-1 2015 Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25758980-1 2015 Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26370177-1 2015 We demonstrate the role of molecular switching of TrkA/p75(NTR) signaling cascade in organophosphate pesticide-Monocrotophos (MCP) induced neurotoxicity in stem cell derived cholinergic neurons and in rat brain. Organophosphates 85-100 nerve growth factor receptor Rattus norvegicus 55-58 25983063-4 2015 In the current study we used zebrafish larvae in order to determine the effects of two of the most widely used organophosphates, chlorpyrifos and malathion, on zebrafish behavior and AChE activity. Organophosphates 111-127 acetylcholinesterase Danio rerio 183-187 26121420-0 2015 Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Organophosphates 68-83 acetylcholinesterase Mus musculus 0-20 26121420-0 2015 Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Organophosphates 68-83 acetylcholinesterase Mus musculus 40-44 26121420-1 2015 Acetylcholinesterase (AChE) is the physiological target of organophosphate nerve agent compounds. Organophosphates 59-74 acetylcholinesterase Mus musculus 0-20 26121420-1 2015 Acetylcholinesterase (AChE) is the physiological target of organophosphate nerve agent compounds. Organophosphates 59-74 acetylcholinesterase Mus musculus 22-26 26121420-6 2015 Thus, this novel fusion product retained its binding affinity toward BW284c5 and propidium, and its bioscavenging reactivity toward the organophosphate-AChE inhibitors sarin and VX. Organophosphates 136-151 acetylcholinesterase Mus musculus 152-156 26121420-8 2015 Owing to its optimized pharmacokinetic performance, high reactivity toward nerve agents, and ease of production, AChE-Fc emerges as a promising next-generation organophosphate bioscavenger. Organophosphates 160-175 acetylcholinesterase Mus musculus 113-117 26535739-1 2015 INTRODUCTION: The determination of cholinesterase (ChE) activity has been commonly applied in the biomonitoring of exposure to organophosphate and carbamate pesticides. Organophosphates 127-142 butyrylcholinesterase Homo sapiens 35-49 26535739-1 2015 INTRODUCTION: The determination of cholinesterase (ChE) activity has been commonly applied in the biomonitoring of exposure to organophosphate and carbamate pesticides. Organophosphates 127-142 butyrylcholinesterase Homo sapiens 51-54 26075493-6 2015 We further evaluated the ability of other organophosphate pesticides including chorpyrifos-methyl, diazinon, parathion-methyl, and azinophos-methyl to inactivate CYP2B6. Organophosphates 42-57 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 162-168 26075493-7 2015 These organophosphate pesticides were also potent MBIs of CYP2B6 characterized by similar kinact and KI values. Organophosphates 6-21 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 58-64 26075493-13 2015 These results indicate that CPS and other organophosphate pesticides are potent MBIs of CYP2B6 which may have implications for the toxicity of these pesticides as well as the potential for pesticide-drug interactions. Organophosphates 42-57 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 88-94 25407587-1 2015 Nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. Organophosphates 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 25407587-1 2015 Nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. Organophosphates 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 25407587-2 2015 The inhibition of AChE by an organophosphate can be reversed by a nucleophilic agent able to dephosphorylate a serine residue in the active site of AChE. Organophosphates 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 25407587-2 2015 The inhibition of AChE by an organophosphate can be reversed by a nucleophilic agent able to dephosphorylate a serine residue in the active site of AChE. Organophosphates 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 26243006-5 2015 Regular monitoring of erythrocyte AChE will enable farmers to identify potential exposure to organophosphate insecticides and take action to reduce exposures and improve their health and safety practices. Organophosphates 93-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 26103614-6 2015 SUMMARY: The therapeutic potential of PON1 should be recognized in preventing atherosclerosis and combating infection and organophosphate toxicity. Organophosphates 122-137 paraoxonase 1 Homo sapiens 38-42 25952704-3 2015 The organophosphate (OP) coumaphos targets acetylcholinesterase (AChE) and is the approved acaricide for eradicating cattle fever tick outbreaks. Organophosphates 4-19 acetylcholinesterase Bos taurus 65-69 25712411-0 2015 Variable response of cholinesterase activities following human exposure to different types of organophosphates. Organophosphates 94-110 butyrylcholinesterase Homo sapiens 21-35 26222853-1 2015 Acute anticholinesterase pesticide (organophosphate and carbamate) poisoning (ACPP) often produces severe complications, and sometimes death. Organophosphates 36-51 acid phosphatase 3 Homo sapiens 78-82 25660508-1 2015 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (i.e., total AChE) in human blood are biomarkers for theranostic monitoring of organophosphate neurotoxin-poisoned patients. Organophosphates 151-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26053868-1 2015 Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation of acetylcholine in the body. Organophosphates 0-15 acetylcholinesterase Mus musculus 178-198 26053868-1 2015 Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation of acetylcholine in the body. Organophosphates 0-15 acetylcholinesterase Mus musculus 200-204 26053868-1 2015 Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation of acetylcholine in the body. Organophosphates 46-62 acetylcholinesterase Mus musculus 178-198 26053868-1 2015 Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation of acetylcholine in the body. Organophosphates 46-62 acetylcholinesterase Mus musculus 200-204 26053868-4 2015 Through in vitro studies, we demonstrated that the biomimetic nanoparticles retain the enzymatic activity of membrane-bound AChE and are able to bind to a model organophosphate, dichlorvos, precluding its inhibitory effect on other enzymatic substrates. Organophosphates 161-176 acetylcholinesterase Mus musculus 124-128 26053868-5 2015 In a mouse model of organophosphate poisoning, the nanoparticles were shown to improve the AChE activity in the blood and markedly improved the survival of dichlorvos-challenged mice. Organophosphates 20-35 acetylcholinesterase Mus musculus 91-95 25660508-1 2015 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (i.e., total AChE) in human blood are biomarkers for theranostic monitoring of organophosphate neurotoxin-poisoned patients. Organophosphates 151-166 butyrylcholinesterase Homo sapiens 55-59 25660508-1 2015 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (i.e., total AChE) in human blood are biomarkers for theranostic monitoring of organophosphate neurotoxin-poisoned patients. Organophosphates 151-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 25701203-2 2015 Here we evaluated the zebrafish as a potential pharmacological model for screening novel oxime antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE). Organophosphates 108-123 acetylcholinesterase Danio rerio 161-165 25937383-1 2015 Organophosphate pesticides cause irreversible inhibition of AChE which leads to neuronal overstimulation and death. Organophosphates 0-15 acetylcholinesterase Danio rerio 60-64 26043064-1 2015 A series of 278 organophosphate compounds acting as acetylcholinesterase inhibitors has been studied. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 25835984-2 2015 Oxime antidotes commonly used to reactivate organophosphate inhibited AChE are ineffective against soman, while the efficacy of the recommended nerve agent bioscavenger butyrylcholinesterase is limited by strictly stoichiometric scavenging. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25809994-2 2015 Phenyl acetate and organophosphates are usually employed as substrates for serum PON1 activity assay. Organophosphates 19-35 paraoxonase 1 Homo sapiens 81-85 25082528-1 2015 Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM). Organophosphates 214-230 acetylcholinesterase Rattus norvegicus 107-127 25082528-1 2015 Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM). Organophosphates 214-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 25867687-1 2015 The allelic distribution at Paraoxonase 1 (PON1) Q192R polymorphism determines differential sensitivity towards certain organophosphate pesticides. Organophosphates 120-135 paraoxonase 1 Homo sapiens 28-41 25867687-1 2015 The allelic distribution at Paraoxonase 1 (PON1) Q192R polymorphism determines differential sensitivity towards certain organophosphate pesticides. Organophosphates 120-135 paraoxonase 1 Homo sapiens 43-47 25949814-2 2015 Organophosphate poisoning (OP) results in various poisoning symptoms due to its strong inhibitory effect on cholinesterase. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 108-122 25949814-5 2015 After she quarreled with her husband and drank 100 ml of malathion, a parasympathomimetic organophosphate that binds irreversibly to cholinesterase, she was transported to our hospital in an ambulance. Organophosphates 90-105 butyrylcholinesterase Homo sapiens 133-147 25186309-0 2015 Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl. Organophosphates 70-86 butyrylcholinesterase Rattus norvegicus 11-25 26334819-4 2015 Organophosphate resistance in mosquito is dependent on alteration in acetylcholinesterase (Ace) gene. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 26334819-4 2015 Organophosphate resistance in mosquito is dependent on alteration in acetylcholinesterase (Ace) gene. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-94 25881174-5 2015 This study aims to assess a novel biomarker that could reflect neuropsychological deterioration associated with long-term exposure to organophosphate pesticides via the enzyme acylpeptide-hydrolase (ACPH), which has been recently identified as a direct target of action for some organophosphate compounds. Organophosphates 134-149 acylaminoacyl-peptide hydrolase Homo sapiens 176-197 25796143-6 2015 Therefore, as a specific biomarker for organophosphate, carbamate pesticides and pyrethroids, the degree of the AChE inhibition with in vivo conditions is a good tool in continuous monitoring of insecticides, which may induce the nerve conduction disorders. Organophosphates 39-54 acetylcholinesterase Oryzias latipes 112-116 25880399-0 2015 Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. Organophosphates 68-83 neuregulin 1 Rattus norvegicus 0-12 25880399-2 2015 We recently demonstrated that NRG-1 blocked delayed neuronal death in rats intoxicated with the organophosphate (OP) neurotoxin diisopropylflurophosphate (DFP). Organophosphates 96-111 neuregulin 1 Rattus norvegicus 30-35 25635583-3 2015 RECENT FINDINGS: The broad PON1 variability in humans, partly due to differences in genetics and age, can confer differential susceptibility because this enzyme can detoxify organophosphate pesticides and has antioxidant properties. Organophosphates 174-189 paraoxonase 1 Homo sapiens 27-31 25732547-3 2015 We show here that resistance to chlorpyrifos, an organophosphate (OP), in Chinese populations of the diamondback moth, Plutella xylostella, is conferred by two mutations of ace1 - the gene encoding the acetylcholinesterase enzyme targeted by OPs - affecting the amino acid sequence of the corresponding protein. Organophosphates 49-64 acetylcholinesterase-like Plutella xylostella 173-177 24912784-0 2015 Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. Organophosphates 77-92 butyrylcholinesterase Homo sapiens 109-130 26417364-0 2015 Paper-based acetylcholinesterase inhibition assay combining a wet system for organophosphate and carbamate pesticides detection. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Organophosphates 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Organophosphates 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 25881174-5 2015 This study aims to assess a novel biomarker that could reflect neuropsychological deterioration associated with long-term exposure to organophosphate pesticides via the enzyme acylpeptide-hydrolase (ACPH), which has been recently identified as a direct target of action for some organophosphate compounds. Organophosphates 134-149 acylaminoacyl-peptide hydrolase Homo sapiens 199-203 25881174-5 2015 This study aims to assess a novel biomarker that could reflect neuropsychological deterioration associated with long-term exposure to organophosphate pesticides via the enzyme acylpeptide-hydrolase (ACPH), which has been recently identified as a direct target of action for some organophosphate compounds. Organophosphates 279-294 acylaminoacyl-peptide hydrolase Homo sapiens 176-197 25881174-5 2015 This study aims to assess a novel biomarker that could reflect neuropsychological deterioration associated with long-term exposure to organophosphate pesticides via the enzyme acylpeptide-hydrolase (ACPH), which has been recently identified as a direct target of action for some organophosphate compounds. Organophosphates 279-294 acylaminoacyl-peptide hydrolase Homo sapiens 199-203 24705954-1 2014 Paraoxonase-1 (PON1) and butyrylcholinesterase (BCHE) are natural bioscavengers of organophosphate acetylcholinesterase inhibitors in the human body, which can determine individual sensitivity to organophosphate toxicity. Organophosphates 83-98 butyrylcholinesterase Homo sapiens 48-52 25510514-0 2015 Affinities of organophosphate flame retardants to tumor suppressor gene p53: an integrated in vitro and in silico study. Organophosphates 14-29 tumor protein p53 Homo sapiens 72-75 25574898-2 2015 PNPLA6 encodes the patatin-like phospholipase domain containing protein 6, also known as neuropathy target esterase (NTE), which is the target of toxic organophosphates that induce human paralysis due to severe axonopathy of large neurons. Organophosphates 152-168 patatin like phospholipase domain containing 6 Homo sapiens 0-6 25574898-2 2015 PNPLA6 encodes the patatin-like phospholipase domain containing protein 6, also known as neuropathy target esterase (NTE), which is the target of toxic organophosphates that induce human paralysis due to severe axonopathy of large neurons. Organophosphates 152-168 patatin like phospholipase domain containing 6 Homo sapiens 19-73 25574898-2 2015 PNPLA6 encodes the patatin-like phospholipase domain containing protein 6, also known as neuropathy target esterase (NTE), which is the target of toxic organophosphates that induce human paralysis due to severe axonopathy of large neurons. Organophosphates 152-168 patatin like phospholipase domain containing 6 Homo sapiens 89-115 25574898-2 2015 PNPLA6 encodes the patatin-like phospholipase domain containing protein 6, also known as neuropathy target esterase (NTE), which is the target of toxic organophosphates that induce human paralysis due to severe axonopathy of large neurons. Organophosphates 152-168 patatin like phospholipase domain containing 6 Homo sapiens 117-120 26460372-2 2015 The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system. Organophosphates 24-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 25304213-0 2015 Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates. Organophosphates 89-105 paraoxonase 1 Homo sapiens 43-56 25304213-0 2015 Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates. Organophosphates 89-105 paraoxonase 1 Homo sapiens 58-62 25304213-2 2015 PON1 hydrolyzes some organophosphates (OPs), including some nerve agents, through nucleophilic attack of hydroxide ion (from water) in the active site. Organophosphates 21-37 paraoxonase 1 Homo sapiens 0-4 25304213-2 2015 PON1 hydrolyzes some organophosphates (OPs), including some nerve agents, through nucleophilic attack of hydroxide ion (from water) in the active site. Organophosphates 39-42 paraoxonase 1 Homo sapiens 0-4 25333763-0 2014 Determination and prediction of the binding interaction between organophosphate flame retardants and p53. Organophosphates 64-79 tumor protein p53 Danio rerio 101-104 25270985-3 2014 AtPAP12 and AtPAP26 were previously isolated from the culture medium of -Pi cell cultures, and shown to be secreted by roots of Arabidopsis seedlings to facilitate Pi scavenging from soil-localized organophosphates. Organophosphates 198-214 purple acid phosphatase 12 Arabidopsis thaliana 0-7 25270985-3 2014 AtPAP12 and AtPAP26 were previously isolated from the culture medium of -Pi cell cultures, and shown to be secreted by roots of Arabidopsis seedlings to facilitate Pi scavenging from soil-localized organophosphates. Organophosphates 198-214 purple acid phosphatase 26 Arabidopsis thaliana 12-19 25581956-6 2014 A correlation between the amount of ingested organophosphates/carbamates (OPs/CMs) and low cholinesterase activity on admission was found. Organophosphates 45-61 butyrylcholinesterase Homo sapiens 91-105 24705954-1 2014 Paraoxonase-1 (PON1) and butyrylcholinesterase (BCHE) are natural bioscavengers of organophosphate acetylcholinesterase inhibitors in the human body, which can determine individual sensitivity to organophosphate toxicity. Organophosphates 83-98 paraoxonase 1 Homo sapiens 0-13 24705954-1 2014 Paraoxonase-1 (PON1) and butyrylcholinesterase (BCHE) are natural bioscavengers of organophosphate acetylcholinesterase inhibitors in the human body, which can determine individual sensitivity to organophosphate toxicity. Organophosphates 83-98 paraoxonase 1 Homo sapiens 15-19 24705954-1 2014 Paraoxonase-1 (PON1) and butyrylcholinesterase (BCHE) are natural bioscavengers of organophosphate acetylcholinesterase inhibitors in the human body, which can determine individual sensitivity to organophosphate toxicity. Organophosphates 83-98 butyrylcholinesterase Homo sapiens 25-46 25291712-3 2015 Pyridinium aldoximes have antidotal effects against poisoning with cholinesterase inhibitors, a frequent problem affecting people working with organophosphate-based insecticides and pesticides. Organophosphates 143-158 butyrylcholinesterase Homo sapiens 67-81 26165279-1 2015 A microdevice for coulometric detection of organophosphate pesticides (OPs) was fabricated based on the measurement of the inhibition of an enzyme, acetylcholinesterase (AChE), by OPs. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 26165279-1 2015 A microdevice for coulometric detection of organophosphate pesticides (OPs) was fabricated based on the measurement of the inhibition of an enzyme, acetylcholinesterase (AChE), by OPs. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 25062436-11 2014 FM550 and its organophosphate components increased human PPARgamma1 transcriptional activity in a Cos7 reporter assay and induced lipid accumulation and perilipin protein expression in BMS2 cells. Organophosphates 14-29 perilipin 1 Homo sapiens 153-162 24680925-3 2014 There is now sufficient evidence to suggest that AChE has a neurotrophic function that may be altered by organophosphate (OP) exposure, resulting in defects of neuronal growth and development, though the clarification of the mechanisms involved require further in vitro investigation. Organophosphates 105-120 acetylcholinesterase Mus musculus 49-53 25190468-1 2014 The search of proficient oximes as reactivators of irreversibly inhibited-AChE by organophosphate poisoning necessitates an appropriate assessment of their physicochemical properties and reactivation kinetics. Organophosphates 82-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 23418070-2 2014 Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon degeneration. Organophosphates 91-107 patatin like phospholipase domain containing 6 Homo sapiens 0-26 23418070-2 2014 Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon degeneration. Organophosphates 91-107 patatin like phospholipase domain containing 6 Homo sapiens 28-31 23418070-2 2014 Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon degeneration. Organophosphates 109-112 patatin like phospholipase domain containing 6 Homo sapiens 0-26 23418070-2 2014 Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon degeneration. Organophosphates 109-112 patatin like phospholipase domain containing 6 Homo sapiens 28-31 26309287-1 2014 Wild Mediterranean fruit fly specimens collected from various regions worldwide were screened for the glycine to alanine (Gly->Ala) point mutation (G328A) in the acetylcholinesterase enzyme, presumably causing resistance to organophosphates. Organophosphates 227-243 acetylcholinesterase-like Ceratitis capitata 165-185 24865421-6 2014 RESULTS: RBC AChE activity levels at presentation and at 24 h of presentation had a negative correlation with duration of mechanical ventilation in subjects who ingested dimethyl organophosphate, but this correlation was not observed for those who had ingested diethyl or unclassified organophosphate. Organophosphates 179-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 24875908-1 2014 The interaction mechanisms of catalase (CAT) with pesticides (including organophosphates: disulfoton, isofenphos-methyl, malathion, isocarbophos, dimethoate, dipterex, methamidophos and acephate; carbamates: carbaryl and methomyl; pyrethroids: fenvalerate and deltamethrin) were first investigated by flow injection (FI) chemiluminescence (CL) analysis and molecular docking. Organophosphates 72-88 catalase Homo sapiens 40-43 24903163-3 2014 PON1 was first discovered as an enzyme to hydrolyze the organophosphate pesticide paraoxon, an activity that both PON2 and PON3 lack. Organophosphates 56-71 paraoxonase 1 Homo sapiens 0-4 24903163-3 2014 PON1 was first discovered as an enzyme to hydrolyze the organophosphate pesticide paraoxon, an activity that both PON2 and PON3 lack. Organophosphates 56-71 paraoxonase 2 Homo sapiens 114-118 24903163-3 2014 PON1 was first discovered as an enzyme to hydrolyze the organophosphate pesticide paraoxon, an activity that both PON2 and PON3 lack. Organophosphates 56-71 paraoxonase 3 Homo sapiens 123-127 24528675-5 2014 On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT). Organophosphates 63-79 purple acid phosphatase 10 Arabidopsis thaliana 130-137 23908134-0 2014 Detection and geographical distribution of the organophosphate resistance-associated Delta3Q ace mutation in the olive fruit fly, Bactrocera oleae (Rossi). Organophosphates 47-62 acetylcholinesterase Bactrocera oleae 93-96 24184599-1 2014 A new, highly sensitive and selective ECL assay biosensor based on target induced signal on has been developed for the detection of organophosphate pesticides (OPs), whereby the smart integration of graphene nanosheets (GNs), CdTe quantum dots (CdTe QDs), and acetylcholinesterase (AChE) enzymatic reaction yields a biofunctional AChE-GNs-QDs hybrid as cathodic ECL emitters for OPs sensing. Organophosphates 132-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-280 24184599-1 2014 A new, highly sensitive and selective ECL assay biosensor based on target induced signal on has been developed for the detection of organophosphate pesticides (OPs), whereby the smart integration of graphene nanosheets (GNs), CdTe quantum dots (CdTe QDs), and acetylcholinesterase (AChE) enzymatic reaction yields a biofunctional AChE-GNs-QDs hybrid as cathodic ECL emitters for OPs sensing. Organophosphates 132-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 282-286 24184599-1 2014 A new, highly sensitive and selective ECL assay biosensor based on target induced signal on has been developed for the detection of organophosphate pesticides (OPs), whereby the smart integration of graphene nanosheets (GNs), CdTe quantum dots (CdTe QDs), and acetylcholinesterase (AChE) enzymatic reaction yields a biofunctional AChE-GNs-QDs hybrid as cathodic ECL emitters for OPs sensing. Organophosphates 132-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 330-334 24716794-1 2014 Radiosynthesis of a fluorine-18 labeled organophosphate (OP) inhibitor of acetylcholinesterase (AChE) and subsequent positron emission tomography (PET) imaging using the tracer in the rat central nervous system are reported. Organophosphates 40-55 acetylcholinesterase Rattus norvegicus 74-94 24716794-1 2014 Radiosynthesis of a fluorine-18 labeled organophosphate (OP) inhibitor of acetylcholinesterase (AChE) and subsequent positron emission tomography (PET) imaging using the tracer in the rat central nervous system are reported. Organophosphates 40-55 acetylcholinesterase Rattus norvegicus 96-100 24902043-1 2014 Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for stoichiometric binding and/or catalytic hydrolysis of organophosphates. Organophosphates 148-164 butyrylcholinesterase Homo sapiens 29-34 24648156-7 2014 The results of the present study also indicate that the use of efficient methods for extracting these enzymes, their kinetic characterization, and determination of sensitivity differences between AChE and BChE to organophosphate compounds are essential for the determination of accurate ChE activity levels for environmental monitoring programs. Organophosphates 213-228 acetylcholinesterase Oreochromis niloticus 196-200 24648156-7 2014 The results of the present study also indicate that the use of efficient methods for extracting these enzymes, their kinetic characterization, and determination of sensitivity differences between AChE and BChE to organophosphate compounds are essential for the determination of accurate ChE activity levels for environmental monitoring programs. Organophosphates 213-228 LOW QUALITY PROTEIN: cholinesterase Oreochromis niloticus 205-209 24666514-1 2014 Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in vascular disease, as well as its use as biomarker of diseases involving oxidative stress, inflammation and liver diseases.This review provides an update about the current knowledge in the field of the analytical procedures that are used for PON1 measurements. Organophosphates 98-113 paraoxonase 1 Homo sapiens 0-13 24666514-1 2014 Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in vascular disease, as well as its use as biomarker of diseases involving oxidative stress, inflammation and liver diseases.This review provides an update about the current knowledge in the field of the analytical procedures that are used for PON1 measurements. Organophosphates 98-113 paraoxonase 1 Homo sapiens 15-19 24598740-3 2014 The previously designed organophosphate-metabolizing reactibody A17 has been re-engineered by replacing its constant kappa light chain by the lambda chain (A17lambda), and the X-ray structure of A17lambda has been determined at 1.95 A resolution. Organophosphates 24-39 immunoglobulin kappa variable 2-30 Homo sapiens 64-67 24528675-5 2014 On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT). Organophosphates 63-79 purple acid phosphatase 12 Arabidopsis thaliana 182-189 24528675-5 2014 On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT). Organophosphates 63-79 purple acid phosphatase 26 Arabidopsis thaliana 233-240 24225313-6 2014 PON1 is also a key detoxifier of organophosphates and organophosphate exposure has been linked to the development of neurological disorders in which acetylcholine plays a significant role. Organophosphates 33-49 paraoxonase 1 Homo sapiens 0-4 24361246-1 2014 Diverse serine hydrolases including endocannabinoid metabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have been suggested as secondary targets for organophosphate (OP) agents to exert adverse toxic effects such as lipid homeostasis disruption. Organophosphates 187-202 fatty acid amide hydrolase Mus musculus 84-99 24225313-6 2014 PON1 is also a key detoxifier of organophosphates and organophosphate exposure has been linked to the development of neurological disorders in which acetylcholine plays a significant role. Organophosphates 33-48 paraoxonase 1 Homo sapiens 0-4 24225313-8 2014 However, many studies suggest that the MM55 PON1 genotype is associated with a higher risk for Parkinson"s disease in individuals exposed to organophosphates. Organophosphates 141-157 paraoxonase 1 Homo sapiens 44-48 24345352-0 2014 Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study. Organophosphates 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24345352-1 2014 Reactivation of organophosphate (OP) inhibited acetylcholinesterase (AChE) by oximes is inadequate against various OP nerve agents known till date owing to their diverse structural features. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 24558370-0 2014 Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration. Organophosphates 0-15 Protein kinase, cAMP-dependent, catalytic subunit 2 Drosophila melanogaster 39-42 24041663-0 2014 Amperometric biosensing of organophosphate and organocarbamate pesticides utilizing polypyrrole entrapped acetylcholinesterase electrode. Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 24041663-1 2014 The work presented here describes a novel, easy and low-cost method of fabrication of a highly sensitive acetylcholinesterase biosensor and its application to detect organophosphate and organocarbamate pesticides. Organophosphates 166-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 24361246-1 2014 Diverse serine hydrolases including endocannabinoid metabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have been suggested as secondary targets for organophosphate (OP) agents to exert adverse toxic effects such as lipid homeostasis disruption. Organophosphates 187-202 fatty acid amide hydrolase Mus musculus 101-105 24361246-1 2014 Diverse serine hydrolases including endocannabinoid metabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have been suggested as secondary targets for organophosphate (OP) agents to exert adverse toxic effects such as lipid homeostasis disruption. Organophosphates 187-202 monoglyceride lipase Mus musculus 111-134 24361246-1 2014 Diverse serine hydrolases including endocannabinoid metabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have been suggested as secondary targets for organophosphate (OP) agents to exert adverse toxic effects such as lipid homeostasis disruption. Organophosphates 187-202 monoglyceride lipase Mus musculus 136-140 24223422-1 2014 This paper describes the molecular modeling design, synthesis and characterization of a new bio-inspired hexapeptide of acetylcholinesterase enzyme and its interaction with the organophosphate pesticide dichlorvos monitored by UV-Vis spectroscopy and mass spectrometry. Organophosphates 177-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 24326413-1 2014 Paraoxonase (PON1) is one of the major players in the detoxification of organophosphates (OPs). Organophosphates 72-88 paraoxonase 1 Homo sapiens 13-17 24326413-1 2014 Paraoxonase (PON1) is one of the major players in the detoxification of organophosphates (OPs). Organophosphates 90-93 paraoxonase 1 Homo sapiens 13-17 24864243-1 2014 Organophosphate compounds can bind to carboxylesterase, which may lower the concentration of organophosphate pesticides at the target site enzyme, cholinesterase. Organophosphates 0-15 butyrylcholinesterase Gallus gallus 147-161 25038995-1 2014 Serum paraoxonase 1 (PON1) has been shown to act as an important guardian against cellular damage from oxidized lipids in low-density lipoprotein (LDL), plasma membrane, against toxic agents such as pesticide residues including organophosphates and against bacterial endotoxin. Organophosphates 228-244 paraoxonase 1 Homo sapiens 21-25 24864243-1 2014 Organophosphate compounds can bind to carboxylesterase, which may lower the concentration of organophosphate pesticides at the target site enzyme, cholinesterase. Organophosphates 93-108 butyrylcholinesterase Gallus gallus 147-161 24291005-1 2014 Organophosphates (OPs) affect behavior by inhibiting acetylcholinesterase (AChE). Organophosphates 18-21 acetylcholinesterase Rattus norvegicus 53-73 25484901-0 2014 Bioactive paper sensor based on the acetylcholinesterase for the rapid detection of organophosphate and carbamate pesticides. Organophosphates 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Organophosphates 126-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Organophosphates 126-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 24417530-3 2014 The results of micronuclei assay and comet assay showed that the reduced blood cholinesterase level from organophosphate pesticide exposure is significantly associated with an increase in chromosome breakage and DNA strand breaks. Organophosphates 105-120 butyrylcholinesterase Homo sapiens 79-93 24534502-3 2014 The organophosphate insecticide chlorpyrifos has been reported to bind with human and bovine serum albumin. Organophosphates 4-19 albumin Homo sapiens 93-106 24220541-2 2014 Our recent work has found that tri-ortho-cresyl phosphate (TOCP), a neuropathic organophosphate (OP), decreased the level of beclin 1 (a key molecule in the process of autophagy) in hen nerve tissues (Song et al., 2012). Organophosphates 80-95 beclin 1 Gallus gallus 125-133 24291005-0 2014 Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression. Organophosphates 69-84 acetylcholinesterase Rattus norvegicus 111-115 24291005-1 2014 Organophosphates (OPs) affect behavior by inhibiting acetylcholinesterase (AChE). Organophosphates 18-21 acetylcholinesterase Rattus norvegicus 75-79 24291005-1 2014 Organophosphates (OPs) affect behavior by inhibiting acetylcholinesterase (AChE). Organophosphates 0-16 acetylcholinesterase Rattus norvegicus 53-73 24291005-1 2014 Organophosphates (OPs) affect behavior by inhibiting acetylcholinesterase (AChE). Organophosphates 0-16 acetylcholinesterase Rattus norvegicus 75-79 24380243-1 2013 Irwin B. Wilson, working in the laboratory of David Nachmansohn at Columbia, demonstrated the ability of hydroxylamine to reactivate cholinesterase inhibited by organophosphates. Organophosphates 161-177 butyrylcholinesterase Homo sapiens 133-147 24249815-1 2013 BACKGROUND: Organophosphate exposures can affect children"s neurodevelopment, possibly due to neurotoxicity induced by acetylcholinesterase (AChE) inhibition, and may affect boys more than girls. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 24249815-1 2013 BACKGROUND: Organophosphate exposures can affect children"s neurodevelopment, possibly due to neurotoxicity induced by acetylcholinesterase (AChE) inhibition, and may affect boys more than girls. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 25536737-1 2014 AIM: To evaluate the usefulness of plasma glucose and serum cholinesterase levels as predictors of organophosphate-induced intermediate syndrome. Organophosphates 99-114 butyrylcholinesterase Homo sapiens 60-74 25536737-11 2014 CONCLUSION: Initial serum cholinesterase and glucose levels measured in the emergency department may be a useful marker in predicting organophosphate-induced intermediate syndrome. Organophosphates 134-149 butyrylcholinesterase Homo sapiens 26-40 24209986-0 2013 [Interest of the cholinesterase assay during organophosphate poisonings]. Organophosphates 45-60 butyrylcholinesterase Homo sapiens 17-31 24246657-0 2013 [Measurement of cholinesterase activity in poisoning with an organophosphate compound: the clinical approach remains essential]. Organophosphates 61-76 butyrylcholinesterase Homo sapiens 16-30 23576326-3 2013 This study aimed to evaluate the susceptibility status of C. quinquefasciatus to temephos, using bioassays, and to investigate its putative resistance mechanisms through biochemical assays and screening of the G119S mutation in the acetylcholinesterase gene, which is associated with organophosphate resistance, carried out by PCR and sequencing. Organophosphates 284-299 acetylcholinesterase Culex quinquefasciatus 232-252 24123308-3 2013 H-PON1 is a strong candidate for the development of catalytic bioscavenger for organophosphate poisoning in humans. Organophosphates 79-94 paraoxonase 1 Homo sapiens 2-6 24123308-9 2013 7, 120) identified amino acid substitutions that significantly increased the activity of chimeric-PON1 variant (4E9) against some organophosphate nerve agents. Organophosphates 130-145 paraoxonase 1 Homo sapiens 98-102 23602893-0 2013 Functional paraoxonase 1 variants modify the risk of Parkinson"s disease due to organophosphate exposure. Organophosphates 80-95 paraoxonase 1 Homo sapiens 11-24 24450247-0 2013 Residues of organophosphate pesticides used in vegetable cultivation in ambient air, surface water and soil in Bueng Niam Subdistrict, Khon Kaen, Thailand. Organophosphates 12-27 transforming growth factor beta regulator 1 Homo sapiens 117-121 24040835-2 2013 AChE is inactivated by organophosphates (OPs) in chemical warfare nerve agents. Organophosphates 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24040835-2 2013 AChE is inactivated by organophosphates (OPs) in chemical warfare nerve agents. Organophosphates 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23424211-0 2013 The role of serum cholinesterase activity and S100B protein in the evaluation of organophosphate poisoning. Organophosphates 81-96 S100 calcium binding protein B Homo sapiens 46-51 23424211-1 2013 The aim of this study was to investigate the role of serum cholinesterase (SChE) activity and S100B protein in the evaluation of patients with acute organophosphate (OP) poisoning. Organophosphates 149-164 S100 calcium binding protein B Homo sapiens 94-99 24039837-1 2013 Acetylcholinesterase (AChE) is commonly used for the detection of organophosphate (OP) and carbamate (CB) insecticides. Organophosphates 66-81 Acetylcholine esterase Drosophila melanogaster 0-20 23735753-3 2013 Here, we report neuroprotective properties for bradykinin against organophosphate poisoning using acute hippocampal slices as an in vitro model. Organophosphates 66-81 kininogen 1 Homo sapiens 47-57 23735753-9 2013 On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin. Organophosphates 88-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23894162-1 2013 BACKGROUND: Paraoxonase 1 (PON1), an esterase that hydrolyzes toxic organophosphates and has antioxidative and antiatherogenic properties, contains a common polymorphism at position 192: glutamine (Q) or arginine (R). Organophosphates 68-84 paraoxonase 1 Homo sapiens 12-25 23894162-1 2013 BACKGROUND: Paraoxonase 1 (PON1), an esterase that hydrolyzes toxic organophosphates and has antioxidative and antiatherogenic properties, contains a common polymorphism at position 192: glutamine (Q) or arginine (R). Organophosphates 68-84 paraoxonase 1 Homo sapiens 27-31 23631528-1 2013 Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon. Organophosphates 213-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 22994801-5 2013 The synthesized compounds 6-12 showed inhibitory effects on paraoxonase-1 (PON1) which is an organophosphate (OP) hydrolyser and an antioxidant bioscavenger enzyme. Organophosphates 93-108 paraoxonase 1 Homo sapiens 60-73 22994801-5 2013 The synthesized compounds 6-12 showed inhibitory effects on paraoxonase-1 (PON1) which is an organophosphate (OP) hydrolyser and an antioxidant bioscavenger enzyme. Organophosphates 93-108 paraoxonase 1 Homo sapiens 75-79 23885349-1 2013 A nanoparticle-based fluorescence immunochromatographic test strip (FITS) coupled with a hand-held detector for highly selective and sensitive detection of phosphorylated acetylcholinesterase (AChE), an exposure biomarker of organophosphate (OP) pesticides and nerve agents, is reported. Organophosphates 225-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 23885349-1 2013 A nanoparticle-based fluorescence immunochromatographic test strip (FITS) coupled with a hand-held detector for highly selective and sensitive detection of phosphorylated acetylcholinesterase (AChE), an exposure biomarker of organophosphate (OP) pesticides and nerve agents, is reported. Organophosphates 225-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 23959117-2 2013 Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23959117-2 2013 Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23917882-2 2013 Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE), critical detoxification enzymes in the blood and in the central nervous system (CNS). Organophosphates 17-33 butyrylcholinesterase Homo sapiens 115-136 23917882-2 2013 Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE), critical detoxification enzymes in the blood and in the central nervous system (CNS). Organophosphates 17-33 butyrylcholinesterase Homo sapiens 138-142 24052154-0 2013 Partial protection from organophosphate-induced cholinesterase inhibition by metyrapone treatment. Organophosphates 24-39 butyrylcholinesterase Rattus norvegicus 48-62 23590812-0 2013 Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients. Organophosphates 78-93 butyrylcholinesterase Homo sapiens 45-59 23602893-1 2013 BACKGROUND: We previously demonstrated that carriers of the "slower metabolizer" MM genotype of paraoxonase (PON1) who were also exposed to ambient organophosphate (OP) pesticides at their residences were at increased risk of developing Parkinson"s disease (PD). Organophosphates 148-163 paraoxonase 1 Homo sapiens 109-113 23566658-2 2013 Toxicity of organophosphates is due to inhibition cholinesterase activity and prolonging the effects of acetylcholine in the receptor site. Organophosphates 12-28 butyrylcholinesterase Homo sapiens 50-64 22960624-1 2013 Organophosphates (OP) inhibit acetylcholinesterase (AChE, EC 3.1.1.7), both in peripheral tissues and central nervous system (CNS), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ACh). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 22884923-0 2013 Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Organophosphates 67-82 paraoxonase 1 Homo sapiens 0-13 22884923-0 2013 Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Organophosphates 67-82 paraoxonase 1 Homo sapiens 15-19 23416173-6 2013 For example, organophosphates, which inhibit acetylcholinesterase as do the drugs used in treating AD symptoms, have also been shown to lead to microtubule derangements and tau hyperphosphorylation, a hallmark of AD. Organophosphates 13-29 microtubule associated protein tau Homo sapiens 173-176 23590198-0 2013 PON1 Q192R and L55M polymorphisms and organophosphate toxicity risk: a meta-analysis. Organophosphates 38-53 paraoxonase 1 Homo sapiens 0-4 23590198-1 2013 Serum paraoxonase (PON1) is an esterase that is involved in the detoxification of organophosphate insecticides. Organophosphates 82-97 paraoxonase 1 Homo sapiens 19-23 23590198-2 2013 Emerging lines of evidence have shown that functional polymorphisms in the PON1 gene might play a critical role in increasing susceptibility to organophosphate toxicity, but individually published studies showed inconclusive results. Organophosphates 144-159 paraoxonase 1 Homo sapiens 75-79 23590198-3 2013 This meta-analysis aimed to derive a more precise estimation of the associations between the PON1 polymorphisms and organophosphate toxicity risk. Organophosphates 116-131 paraoxonase 1 Homo sapiens 93-97 23590198-5 2013 The meta-analysis results showed that the PON1 192Q and 55L polymorphisms may increase the risk of organophosphate toxicity. Organophosphates 99-114 paraoxonase 1 Homo sapiens 42-46 23590198-6 2013 Further subgroup analyses by ethnicity showed significant associations of the PON1 192Q and 55L polymorphisms with increased risk of organophosphate toxicity among the Caucasian populations. Organophosphates 133-148 paraoxonase 1 Homo sapiens 78-82 23590198-8 2013 In conclusion, the current meta-analysis indicates that the PON1 192Q and 55LM polymorphisms may increase the risk of organophosphate toxicity, especially among the Caucasian populations. Organophosphates 118-133 paraoxonase 1 Homo sapiens 60-64 23123249-1 2013 A critical need for combating the effects of organophosphate (OP) anticholinesterases, such as nerve agents, is the current lack of an effective oxime reactivator which can penetrate the blood-brain barrier (BBB), and therefore reactivate inhibited acetylcholinesterase (AChE) in the brain. Organophosphates 45-60 acetylcholinesterase Rattus norvegicus 249-269 23123249-1 2013 A critical need for combating the effects of organophosphate (OP) anticholinesterases, such as nerve agents, is the current lack of an effective oxime reactivator which can penetrate the blood-brain barrier (BBB), and therefore reactivate inhibited acetylcholinesterase (AChE) in the brain. Organophosphates 45-60 acetylcholinesterase Rattus norvegicus 271-275 23658746-3 2013 A few studies in adults and adolescents suggest a link between obesity and paraoxonase 1 (PON1), a multifunctional enzyme that can metabolize organophosphate pesticides and also has antioxidant properties. Organophosphates 142-157 paraoxonase 1 Homo sapiens 75-88 23658746-3 2013 A few studies in adults and adolescents suggest a link between obesity and paraoxonase 1 (PON1), a multifunctional enzyme that can metabolize organophosphate pesticides and also has antioxidant properties. Organophosphates 142-157 paraoxonase 1 Homo sapiens 90-94 23453838-1 2013 Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Organophosphates 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 23453838-1 2013 Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Organophosphates 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 23453838-1 2013 Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Organophosphates 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 23044488-1 2013 Human serum butyrylcholinesterase (HuBChE) is currently the most suitable bioscavenger for the prophylaxis of highly toxic organophosphate (OP) nerve agents. Organophosphates 123-138 butyrylcholinesterase Homo sapiens 12-33 23379291-4 2013 Organophosphates comprise a class of insecticides used for sand fly control, which act through the inhibition of acetylcholinesterase (AChE) in the central nervous system. Organophosphates 0-16 Acetylcholine esterase Drosophila melanogaster 113-133 23178380-1 2013 Butyrylcholinesterase (BChE) is the leading pretreatment candidate against exposure to organophosphates (OPs), which pose an ever increasing public and military health. Organophosphates 87-103 butyrylcholinesterase Homo sapiens 0-21 23178380-1 2013 Butyrylcholinesterase (BChE) is the leading pretreatment candidate against exposure to organophosphates (OPs), which pose an ever increasing public and military health. Organophosphates 87-103 butyrylcholinesterase Homo sapiens 23-27 23178380-1 2013 Butyrylcholinesterase (BChE) is the leading pretreatment candidate against exposure to organophosphates (OPs), which pose an ever increasing public and military health. Organophosphates 105-108 butyrylcholinesterase Homo sapiens 0-21 23178380-1 2013 Butyrylcholinesterase (BChE) is the leading pretreatment candidate against exposure to organophosphates (OPs), which pose an ever increasing public and military health. Organophosphates 105-108 butyrylcholinesterase Homo sapiens 23-27 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23216060-1 2013 In the present paper we show a comprehensive in vitro, ex vivo and in vivo study on hydrolytic detoxification of nerve agent and pesticide OPs (organophosphates) catalysed by purified hBChE (human butyrylcholinesterase) in combination with novel non-pyridinium oxime reactivators. Organophosphates 139-142 butyrylcholinesterase Homo sapiens 184-189 23216060-1 2013 In the present paper we show a comprehensive in vitro, ex vivo and in vivo study on hydrolytic detoxification of nerve agent and pesticide OPs (organophosphates) catalysed by purified hBChE (human butyrylcholinesterase) in combination with novel non-pyridinium oxime reactivators. Organophosphates 144-160 butyrylcholinesterase Homo sapiens 184-189 23410111-1 2013 Organophosphate nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 23410111-1 2013 Organophosphate nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 23379291-4 2013 Organophosphates comprise a class of insecticides used for sand fly control, which act through the inhibition of acetylcholinesterase (AChE) in the central nervous system. Organophosphates 0-16 Acetylcholine esterase Drosophila melanogaster 135-139 23379291-5 2013 Point mutations producing an altered, insensitive AChE are a major mechanism of organophosphate resistance in insects and preliminary evidence for organophosphate-insensitive AChE has been reported in sand flies. Organophosphates 80-95 Acetylcholine esterase Drosophila melanogaster 50-54 23936791-3 2013 As a specific molecular target of organophosphate and carbamate pesticides, acetylcholinesterase activity and its inhibition has been early recognized to be a human biological marker of pesticide poisoning. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 22990135-0 2013 Quantitative structure-activity relationships for organophosphates binding to acetylcholinesterase. Organophosphates 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 22990135-1 2013 Organophosphates are a group of pesticides and chemical warfare nerve agents that inhibit acetylcholinesterase, the enzyme responsible for hydrolysis of the excitatory neurotransmitter acetylcholine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 22990135-16 2013 The results suggest that this QSAR model can be used in physiologically based pharmacokinetic/pharmacodynamic models of organophosphate toxicity to determine the rate of acetylcholinesterase inhibition. Organophosphates 120-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 22868055-0 2013 Biosensor based on acetylcholinesterase immobilized onto layered double hydroxides for flow injection/amperometric detection of organophosphate pesticides. Organophosphates 128-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 22897592-0 2013 Pkb/Akt1 mediates Wnt/GSK3beta/beta-catenin signaling-induced apoptosis in human cord blood stem cells exposed to organophosphate pesticide monocrotophos. Organophosphates 114-129 protein tyrosine kinase 2 beta Homo sapiens 0-3 22897592-0 2013 Pkb/Akt1 mediates Wnt/GSK3beta/beta-catenin signaling-induced apoptosis in human cord blood stem cells exposed to organophosphate pesticide monocrotophos. Organophosphates 114-129 AKT serine/threonine kinase 1 Homo sapiens 4-8 22897592-0 2013 Pkb/Akt1 mediates Wnt/GSK3beta/beta-catenin signaling-induced apoptosis in human cord blood stem cells exposed to organophosphate pesticide monocrotophos. Organophosphates 114-129 glycogen synthase kinase 3 beta Homo sapiens 22-30 22897592-0 2013 Pkb/Akt1 mediates Wnt/GSK3beta/beta-catenin signaling-induced apoptosis in human cord blood stem cells exposed to organophosphate pesticide monocrotophos. Organophosphates 114-129 catenin beta 1 Homo sapiens 31-43 24163803-2 2013 Organophosphate (OP) and carbamate group of pesticides can inhibit acetylcholinesterase; on the other hand, paraoxonase1 can detoxify organophosphate poisoning by hydrolyzing organophosphate metabolites. Organophosphates 134-149 paraoxonase 1 Homo sapiens 108-120 24163803-2 2013 Organophosphate (OP) and carbamate group of pesticides can inhibit acetylcholinesterase; on the other hand, paraoxonase1 can detoxify organophosphate poisoning by hydrolyzing organophosphate metabolites. Organophosphates 175-190 paraoxonase 1 Homo sapiens 108-120 24163803-6 2013 CONCLUSION: Our results suggest that subjects with higher paraoxonase1 activity may have a better chance of detoxifying the lethal effect of acute organophosphate poisoning. Organophosphates 147-162 paraoxonase 1 Homo sapiens 58-70 23936791-4 2013 Measurement of AChE inhibition has been increasingly used in the last two decades as a biomarker of effect on nervous system following exposure to organophosphate and carbamate pesticides in occupational and environmental medicine. Organophosphates 147-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 23170819-0 2013 The difference in C-reactive protein value between initial and 24 hours follow-up (D-CRP) data as a predictor of mortality in organophosphate poisoned patients. Organophosphates 126-141 C-reactive protein Homo sapiens 18-36 23170819-2 2013 The aim of this study was to evaluate the relationship between the serum C-reactive protein activity and clinical outcome in acute organophosphate-poisoned patients. Organophosphates 131-146 C-reactive protein Homo sapiens 73-91 23170819-11 2013 However, the difference in C-reactive protein value between initial and follow-up after 24 hours (D-CRP) was associated with mortality in the total population of patients with acute organophosphate poisoning. Organophosphates 182-197 C-reactive protein Homo sapiens 27-45 23531217-1 2013 K203 is an experimental bis-pyridinium mono-aldoxime type cholinesterase reactivator of potential use in organophosphate/ organophosphonate poisoning. Organophosphates 105-120 butyrylcholinesterase Rattus norvegicus 58-72 24148993-3 2013 Natural anti-AChE includes carbamates, glycoalkaloids, anatoxins derived from green algae; synthetic anti-AChE includes highly poisonous organophosphates used as nerve gases and insecticides. Organophosphates 137-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 21717485-1 2013 K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-propane dibromide] is a promising new reactivator of organophosphate- or organophosphonate-inhibited acetylcholinesterase (AChE) with low acute toxicity and broad spectrum efficacy. Organophosphates 120-135 acetylcholinesterase Rattus norvegicus 168-188 21717485-1 2013 K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-propane dibromide] is a promising new reactivator of organophosphate- or organophosphonate-inhibited acetylcholinesterase (AChE) with low acute toxicity and broad spectrum efficacy. Organophosphates 120-135 acetylcholinesterase Rattus norvegicus 190-194 24362097-2 2013 Treatment after exposure to organophosphates involves the use of parasympatolytics, acetylcholinesterase (AChE) reactivators/modulators and anticonvulsive drugs. Organophosphates 28-44 acetylcholinesterase (Yt blood group) Sus scrofa 84-104 24362097-2 2013 Treatment after exposure to organophosphates involves the use of parasympatolytics, acetylcholinesterase (AChE) reactivators/modulators and anticonvulsive drugs. Organophosphates 28-44 acetylcholinesterase (Yt blood group) Sus scrofa 106-110 23946555-1 2012 We designed, synthesized and screened a library of analogs of the organophosphate pesticide metabolite paraoxon against a recombinant variant of human serum paraoxonase-1. Organophosphates 66-81 paraoxonase 1 Homo sapiens 157-170 23536865-0 2013 Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase. Organophosphates 50-65 butyrylcholinesterase Homo sapiens 89-110 23244429-0 2012 Acetylcholinesterase inhibitors as pretreatment before acute exposure to organophosphates: assessment using methyl-paraoxon. Organophosphates 73-89 acetylcholinesterase Rattus norvegicus 0-20 23393758-1 2012 Insecticide resistance to organophosphates and carbamates can be the result of changes in acetylcholinesterase activity conferred by the ACE-1 mutation. Organophosphates 26-42 acetylcholinesterase Culex quinquefasciatus 90-110 22956723-1 2012 Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for the catalytic hydrolysis or stoichiometric binding of organophosphates (OPs). Organophosphates 148-164 butyrylcholinesterase Homo sapiens 29-34 23013366-4 2012 Moreover, organophosphate poisoning is frequently diagnosed via a cholinesterase activity assay. Organophosphates 10-25 butyrylcholinesterase Homo sapiens 66-80 22971832-1 2012 Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. Organophosphates 145-161 paraoxonase 1 Homo sapiens 12-25 23184105-5 2012 Organophosphate and carbamate poisoning are perhaps the most widely known acute poisoning syndromes, can be diagnosed by depressed red blood cell cholinesterase levels, and have available antidotal therapy. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 146-160 22971832-1 2012 Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. Organophosphates 145-161 paraoxonase 1 Homo sapiens 27-31 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 97-118 22760442-1 2012 Exposure to organophosphate and carbamate pesticides can lead to neurotoxic effects through inhibition of cholinesterase enzymes. Organophosphates 12-27 butyrylcholinesterase Homo sapiens 106-120 22760442-2 2012 The paraoxonase (PON1) enzyme can detoxify oxon derivatives of some organophosphates. Organophosphates 68-84 paraoxonase 1 Homo sapiens 17-21 22760442-3 2012 Lower PON1, acetylcholinesterase, and butyrylcholinesterase activities have been reported in newborns relative to adults, suggesting increased susceptibility to organophosphate exposure in young children. Organophosphates 161-176 paraoxonase 1 Homo sapiens 6-10 22781438-1 2012 Human exposure to preformed dialkylphosphates (DAPs) in food or the environment may affect the reliability of DAP urinary metabolites as biomarkers of organophosphate (OP) pesticide exposure. Organophosphates 151-166 death associated protein Homo sapiens 47-50 23256657-5 2012 Such an appropriate system for the detection of carbamates and highly toxic organophosphates is detection tubes with microcrystalline cellulose pellets containing immobilized acetylcholinesterase, by which analyzed air is sucked through. Organophosphates 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 23256999-1 2012 OBJECTIVE: To study the changes in the levels of autophagy-related proteins, Atg1, Atg5, and Beclin1, in organophosphate-induced delayed neuropathy (OPIDN) caused by tri-ortho-cresyl phosphate (TOCP), and to investigate the molecular pathogenic mechanism of OPIDN. Organophosphates 105-120 autophagy related 5 Gallus gallus 83-87 23256999-1 2012 OBJECTIVE: To study the changes in the levels of autophagy-related proteins, Atg1, Atg5, and Beclin1, in organophosphate-induced delayed neuropathy (OPIDN) caused by tri-ortho-cresyl phosphate (TOCP), and to investigate the molecular pathogenic mechanism of OPIDN. Organophosphates 105-120 beclin 1 Gallus gallus 93-100 22901080-2 2012 PON1 also hydrolyzes organophosphates, protecting the nervous system from those neurotoxic compounds. Organophosphates 21-37 paraoxonase 1 Homo sapiens 0-4 22608349-2 2012 Acetylcholinesterase (AChE), an enzyme that hydrolyses acetylcholine (ACh) at cholinergic synapses, is a target for pesticides and its inhibition by organophosphates leads to paralysis and death of arthropods. Organophosphates 149-165 acetylcholinesterase Rattus norvegicus 0-20 22608349-2 2012 Acetylcholinesterase (AChE), an enzyme that hydrolyses acetylcholine (ACh) at cholinergic synapses, is a target for pesticides and its inhibition by organophosphates leads to paralysis and death of arthropods. Organophosphates 149-165 acetylcholinesterase Rattus norvegicus 22-26 21985443-1 2012 Serum paraoxonase 1 (EC 3.1.8.1, PON1), a calcium-associated enzyme, has an ability to hydrolyze organophosphate compounds. Organophosphates 97-112 paraoxonase 1 Bos taurus 6-19 21985443-1 2012 Serum paraoxonase 1 (EC 3.1.8.1, PON1), a calcium-associated enzyme, has an ability to hydrolyze organophosphate compounds. Organophosphates 97-112 paraoxonase 1 Bos taurus 33-37 23136724-6 2012 Some fifty years later Wilson, working in the laboratory of Nachmansohn, demonstrated the ability of hydroxylamine to reactivate cholinesterase inhibited by organophosphates. Organophosphates 157-173 butyrylcholinesterase Homo sapiens 129-143 22578704-1 2012 Organophosphates (OPs) inhibit the enzyme cholinesterase and cause accumulation of acetylcholine, and are known to cause seizures and status epilepticus (SE) in humans. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 42-56 22578704-1 2012 Organophosphates (OPs) inhibit the enzyme cholinesterase and cause accumulation of acetylcholine, and are known to cause seizures and status epilepticus (SE) in humans. Organophosphates 18-21 butyrylcholinesterase Homo sapiens 42-56 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 120-124 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 18-21 butyrylcholinesterase Homo sapiens 97-118 23293463-0 2012 A retrospective analysis of serial measurement of serum cholinesterase in acute poisoning with organophosphate compounds. Organophosphates 95-110 butyrylcholinesterase Homo sapiens 56-70 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 18-21 butyrylcholinesterase Homo sapiens 120-124 23293463-1 2012 OBJECTIVES: Retrospective analysis of the utility of serial measurements of serum acetylcholinesterase (AChE) in predicting the duration of stay in the intensive care unit (ICU), duration of mechanical ventilation (MV) and outcome of the patient from MV in organophosphate (OP) compound poisoning patients. Organophosphates 257-272 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 22503708-0 2012 NTE and non-NTE esterases in brain membrane: kinetic characterization with organophosphates. Organophosphates 75-91 patatin like phospholipase domain containing 6 Gallus gallus 0-3 22513003-5 2012 The GR-CS/GCE was used to detect organophosphate pesticides (OPs), using methyl parathion (MP) as a model analyte. Organophosphates 33-48 aminomethyltransferase Homo sapiens 10-13 22683313-7 2012 Significant associations between organophosphate pesticide levels in blood and metabolite levels in urine were limited to models adjusting for PON1 levels. Organophosphates 33-48 paraoxonase 1 Homo sapiens 143-147 22683313-10 2012 However, compared to their mothers, newborns have much lower quantities of the detoxifying PON1 enzyme suggesting that infants may be especially vulnerable to organophosphate pesticide exposures. Organophosphates 159-174 paraoxonase 1 Homo sapiens 91-95 22704918-2 2012 The arylesterase paraoxonase 1 (PON1) is mainly expressed in the liver and hydrolyzes organophosphates such as pesticides. Organophosphates 86-102 paraoxonase 1 Homo sapiens 17-30 22704918-2 2012 The arylesterase paraoxonase 1 (PON1) is mainly expressed in the liver and hydrolyzes organophosphates such as pesticides. Organophosphates 86-102 paraoxonase 1 Homo sapiens 32-36 22503708-0 2012 NTE and non-NTE esterases in brain membrane: kinetic characterization with organophosphates. Organophosphates 75-91 patatin like phospholipase domain containing 6 Gallus gallus 12-15 22651251-1 2012 Organophosphates are some of the most acutely toxic compounds synthesized on an industrial scale, and organophosphorus hydrolase (OPH) has the ability to hydrolyze and inactivate a number of these chemicals. Organophosphates 0-16 acylaminoacyl-peptide hydrolase Homo sapiens 130-133 22583949-0 2012 Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury. Organophosphates 50-65 neuregulin 1 Rattus norvegicus 0-12 22651251-4 2012 Silk fibroin entrapment of OPH also allowed for its dispersal into a polyurethane-based coating that retained organophosphate hydrolysis activity after formulation, application and drying. Organophosphates 110-125 acylaminoacyl-peptide hydrolase Homo sapiens 27-30 22649796-0 2012 Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships. Organophosphates 71-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 22624144-1 2012 This work reports a sensitive amperometric biosensor for organophosphate pesticides (OPs) fabricated by modifying a glassy carbon electrode with acetylcholinesterase (AChE) immobilized on ionic liquid-functionalized graphene (IL-G). Organophosphates 57-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 22624144-1 2012 This work reports a sensitive amperometric biosensor for organophosphate pesticides (OPs) fabricated by modifying a glassy carbon electrode with acetylcholinesterase (AChE) immobilized on ionic liquid-functionalized graphene (IL-G). Organophosphates 57-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 22498093-1 2012 Organophosphate (OP)-induced brain damage is defined as progressive damage to the brain, resulting from the cholinergic neuronal excitotoxicity and dysfunction induced by OP-induced irreversible AChE inhibition. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 22381367-1 2012 Two microplate spectroscopic methods for determination of organophosphates, based on inhibition of acetylcholinesterase (AChE) activity, were further improved and evaluated for determination of the chemical weapon agent Russian VX (RVX) in aqueous solutions. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 22381367-1 2012 Two microplate spectroscopic methods for determination of organophosphates, based on inhibition of acetylcholinesterase (AChE) activity, were further improved and evaluated for determination of the chemical weapon agent Russian VX (RVX) in aqueous solutions. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 22414384-1 2012 Paraoxonase-1 (PON1) is a native enzyme that is synthesized in the liver and is capable of hydrolyzing organophosphates (OPs). Organophosphates 103-119 paraoxonase 1 Homo sapiens 0-13 22306305-0 2012 Cytotoxic and necrotic responses in human amniotic epithelial (WISH) cells exposed to organophosphate insecticide phorate. Organophosphates 86-101 NCK interacting protein with SH3 domain Homo sapiens 63-67 22414384-1 2012 Paraoxonase-1 (PON1) is a native enzyme that is synthesized in the liver and is capable of hydrolyzing organophosphates (OPs). Organophosphates 103-119 paraoxonase 1 Homo sapiens 15-19 22414384-1 2012 Paraoxonase-1 (PON1) is a native enzyme that is synthesized in the liver and is capable of hydrolyzing organophosphates (OPs). Organophosphates 121-124 paraoxonase 1 Homo sapiens 0-13 22414384-1 2012 Paraoxonase-1 (PON1) is a native enzyme that is synthesized in the liver and is capable of hydrolyzing organophosphates (OPs). Organophosphates 121-124 paraoxonase 1 Homo sapiens 15-19 22316628-1 2012 Chlorpyrifos (CPF) is a widely used organophosphate insecticide which could bind with human serum albumin (HSA) and bovine serum albumin (BSA). Organophosphates 36-51 albumin Homo sapiens 92-105 21739279-0 2012 Organophosphate pesticide environmental exposure: analysis of salivary cholinesterase and carboxilesterase activities in preschool children and their mothers. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 71-85 21739279-1 2012 A pilot study was conducted to evaluate the usefulness of salivary cholinesterase and carboxylesterase as biomarkers of exposure to environmental organophosphate pesticides. Organophosphates 146-161 butyrylcholinesterase Homo sapiens 67-81 22301377-0 2012 Crossroads in the evaluation of paraoxonase 1 for protection against nerve agent and organophosphate toxicity. Organophosphates 85-100 paraoxonase 1 Homo sapiens 32-45 22301377-3 2012 Hydrolysis of various organophosphates (OPs) and chemical warfare nerve agents (CWNAs) by PON1 has been demonstrated in both in vitro and in vivo experiments. Organophosphates 22-38 paraoxonase 1 Homo sapiens 90-94 22301377-3 2012 Hydrolysis of various organophosphates (OPs) and chemical warfare nerve agents (CWNAs) by PON1 has been demonstrated in both in vitro and in vivo experiments. Organophosphates 40-43 paraoxonase 1 Homo sapiens 90-94 22444575-2 2012 The inhibition of butyrylcholinesterase (BChE) activity by paraoxon is due to the formation of phosphorylated BChE adduct, and the detection of the phosphorylated BChE adduct in human plasma can serve as an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 229-244 butyrylcholinesterase Homo sapiens 18-39 22444575-2 2012 The inhibition of butyrylcholinesterase (BChE) activity by paraoxon is due to the formation of phosphorylated BChE adduct, and the detection of the phosphorylated BChE adduct in human plasma can serve as an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 229-244 butyrylcholinesterase Homo sapiens 41-45 22444575-2 2012 The inhibition of butyrylcholinesterase (BChE) activity by paraoxon is due to the formation of phosphorylated BChE adduct, and the detection of the phosphorylated BChE adduct in human plasma can serve as an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 229-244 butyrylcholinesterase Homo sapiens 110-114 22444575-2 2012 The inhibition of butyrylcholinesterase (BChE) activity by paraoxon is due to the formation of phosphorylated BChE adduct, and the detection of the phosphorylated BChE adduct in human plasma can serve as an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 229-244 butyrylcholinesterase Homo sapiens 110-114 22444575-8 2012 Thus, immunoaffinity purification combined with LC-MS represents a viable approach for the detection and quantification of phosphorylated BChE as an exposure biomarker of organophosphates and nerve agents. Organophosphates 171-187 butyrylcholinesterase Homo sapiens 138-142 22343626-1 2012 We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Organophosphates 227-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 22316628-1 2012 Chlorpyrifos (CPF) is a widely used organophosphate insecticide which could bind with human serum albumin (HSA) and bovine serum albumin (BSA). Organophosphates 36-51 albumin Homo sapiens 123-136 22230262-0 2012 Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 22310298-6 2012 While PXR was predominantly activated by pyrethroids, CAR was, in addition to pyrethroids, well activated by organophosphates and several carbamates. Organophosphates 109-125 nuclear receptor subfamily 1 group I member 3 Homo sapiens 54-57 22310298-9 2012 CYP2B6 was induced fairly equally by organophosphate, carbamate and pyrethroid compounds. Organophosphates 37-52 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-6 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Organophosphates 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Organophosphates 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21867409-4 2012 Each PON member has high catalytic activity toward corresponding artificial organophosphate, and all exhibit activities to lactones. Organophosphates 76-91 paraoxonase 1 Homo sapiens 5-8 22464501-3 2012 Reduced serum pseudocholinesterase supports a diagnosis of organophosphate toxicity, but there is no similar laboratory test for amitraz poisoning. Organophosphates 59-74 butyrylcholinesterase Homo sapiens 14-34 22160885-5 2012 Plasma cholinesterase activity was higher in animals receiving enzyme and oxime before the organophosphates than in the oxime-only pretreated groups. Organophosphates 91-107 butyrylcholinesterase Homo sapiens 7-21 22285544-2 2012 Organophosphates inhibit acetylcholinesterase and neurotoxicity is primarily a result of acetylcholine induced hyperactivation in different regions of the brain. Organophosphates 0-16 acetylcholinesterase Rattus norvegicus 25-45 22125290-1 2012 OBJECTIVES: Oximes such as pralidoxime (2-PAM) are essential antidotes for life-threatening organophosphate poisoning. Organophosphates 92-107 peptidylglycine alpha-amidating monooxygenase Homo sapiens 42-45 21922192-1 2012 Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly. Organophosphates 23-38 acetylcholinesterase Mus musculus 58-78 21998030-0 2012 Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 22285544-4 2012 Determining the severity of acetylcholinesterase inhibition that induces oxidative damage may help in developing strategies that protect the brain from organophosphate induced toxicity. Organophosphates 152-167 acetylcholinesterase Rattus norvegicus 28-48 22285544-5 2012 AIM: To determine the level of acetylcholinesterase inhibition that induces oxidative stress in the brain following organophosphate pesticide poisoning. Organophosphates 116-131 acetylcholinesterase Rattus norvegicus 31-51 22083726-10 2012 Furthermore, Cyp2b-KD mice are sensitive to parathion, an organophosphate insecticide primarily metabolized by Cyp2b enzymes, when compared with WT mice. Organophosphates 58-73 cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus 13-18 21872994-5 2012 These data will enable rapid identification and assay for mutations that reduce AChE sensitivity to organophosphate (OP) pesticides, potentially aiding resistance management efforts to prevent fixation of the mutations in pest populations. Organophosphates 100-115 acetylcholinesterase Stomoxys calcitrans 80-84 22306579-3 2012 Using this method, we engineered a zinc-containing mouse adenosine deaminase to catalyze the hydrolysis of a model organophosphate with a catalytic efficiency (k(cat)/K(m)) of ~10(4) M(-1) s(-1) after directed evolution. Organophosphates 115-130 adenosine deaminase Mus musculus 57-76 22193970-1 2012 Human paraoxonase 1 (huPON1) is a calcium-dependent esterase responsible for hydrolysis of a wide variety of substrates including organophosphates, esters, lactones, and paraoxon. Organophosphates 130-146 paraoxonase 1 Homo sapiens 6-19 22177963-1 2012 Acute organophosphate (OP) intoxication is important because of its high morbidity and mortality and occurrence of muscular paralysis associated by inhibition of acetylcholinesterase (AChE) activity at the neuromuscular junction. Organophosphates 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 22177963-1 2012 Acute organophosphate (OP) intoxication is important because of its high morbidity and mortality and occurrence of muscular paralysis associated by inhibition of acetylcholinesterase (AChE) activity at the neuromuscular junction. Organophosphates 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 22476468-4 2012 Previously, we showed that overexpression of Arabidopsis purple acid phosphatase 10 (AtPAP10) improved the growth of plants on Pi-deficient medium (P- medium) supplemented with the organophosphate compound ADP; in contrast, the growth of atpap10 mutant lines was reduced on the same medium. Organophosphates 181-196 purple acid phosphatase 10 Arabidopsis thaliana 57-83 22476468-4 2012 Previously, we showed that overexpression of Arabidopsis purple acid phosphatase 10 (AtPAP10) improved the growth of plants on Pi-deficient medium (P- medium) supplemented with the organophosphate compound ADP; in contrast, the growth of atpap10 mutant lines was reduced on the same medium. Organophosphates 181-196 purple acid phosphatase 10 Arabidopsis thaliana 85-92 22476468-6 2012 The results showed that AtPAP10 could utilize rhizosphere organophosphates other than ADP for plant growth but with different utilization efficiencies. Organophosphates 58-74 purple acid phosphatase 10 Arabidopsis thaliana 24-31 22120822-1 2012 Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. Organophosphates 115-131 peptidase D Homo sapiens 6-15 22120822-1 2012 Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. Organophosphates 115-131 peptidase D Homo sapiens 17-21 22273496-6 2012 Exposure to organophosphates significantly reduced AChE activity across season, but was not sufficient enough to claim clinical symptoms whereas exposure to the pyrethroid insecticides and fungicides were sufficient enough to claim acute symptoms of poisoning. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 22120822-2 2012 To develop PROL as a catalytic bioscavenger, we evaluated the in vitro hydrolysis efficiency of purified recombinant human PROL against organophosphates and nerve agents. Organophosphates 136-152 peptidase D Homo sapiens 123-127 22148672-4 2012 On the other hand, the hydrolysis of ATCl is inhibited in the presence of ACh or organophosphate pesticides (OPs, a AChE inhibitor), which will decrease the catalytic growth of Au NPs and, as a result, reduce the orientational response of LCs. Organophosphates 81-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 23030612-7 2012 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans. Organophosphates 218-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23001316-1 2012 BACKGROUND: Paraoxonase 1 (PON1) is important in organophosphates and xenobiotic metabolism and as an antioxidant bio-scavenger. Organophosphates 49-65 paraoxonase 1 Homo sapiens 12-25 23001316-1 2012 BACKGROUND: Paraoxonase 1 (PON1) is important in organophosphates and xenobiotic metabolism and as an antioxidant bio-scavenger. Organophosphates 49-65 paraoxonase 1 Homo sapiens 27-31 21989207-1 2011 AIMS: Due to pralidoxime chloride"s (2-PAM) positive charge, it"s penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor. Organophosphates 136-151 acetylcholinesterase Cavia porcellus 196-216 23277710-0 2012 Regeneration of Red Cell Cholinesterase Activity Following Pralidoxime (2-PAM) Infusion in First 24 h in Organophosphate Poisoned Patients. Organophosphates 105-120 butyrylcholinesterase Homo sapiens 25-39 23277710-0 2012 Regeneration of Red Cell Cholinesterase Activity Following Pralidoxime (2-PAM) Infusion in First 24 h in Organophosphate Poisoned Patients. Organophosphates 105-120 peptidylglycine alpha-amidating monooxygenase Homo sapiens 74-77 21972196-3 2012 Findings presented here indicate that red blood cell acetylcholinesterase is similarly protected by pyridostigmine bromide from the action of diisopropyl fluorophosphate and several organophosphate pesticides including chlorpyrifos-oxon, diazinon-oxon, and paraoxon, but not malaoxon, using the bovine red blood cell as a subject. Organophosphates 182-197 acetylcholinesterase Bos taurus 53-73 23373324-1 2012 BACKGROUND: Toxicity of organophosphate insecticides is mainly due to the inhibition of acetylcholinesterase (AChE). Organophosphates 24-39 acetylcholinesterase Rattus norvegicus 88-108 23373324-1 2012 BACKGROUND: Toxicity of organophosphate insecticides is mainly due to the inhibition of acetylcholinesterase (AChE). Organophosphates 24-39 acetylcholinesterase Rattus norvegicus 110-114 20947215-1 2012 Paraoxonase-1 (PON1) is a serum arylsulfatase that metabolizes organophosphate pesticides and protects low-density lipoprotein from oxidation. Organophosphates 63-78 paraoxonase 1 Homo sapiens 0-13 20947215-1 2012 Paraoxonase-1 (PON1) is a serum arylsulfatase that metabolizes organophosphate pesticides and protects low-density lipoprotein from oxidation. Organophosphates 63-78 paraoxonase 1 Homo sapiens 15-19 21989207-13 2011 SIGNIFICANCE: The present study shows that pro-2-PAM was rapidly oxidized by riboflavin to 2-PAM, which reactivated organophosphate (OP)-inhibited AChE. Organophosphates 116-131 peptidyl-glycine alpha-amidating monooxygenase Cavia porcellus 49-52 21989207-13 2011 SIGNIFICANCE: The present study shows that pro-2-PAM was rapidly oxidized by riboflavin to 2-PAM, which reactivated organophosphate (OP)-inhibited AChE. Organophosphates 116-131 peptidyl-glycine alpha-amidating monooxygenase Cavia porcellus 93-96 21989207-13 2011 SIGNIFICANCE: The present study shows that pro-2-PAM was rapidly oxidized by riboflavin to 2-PAM, which reactivated organophosphate (OP)-inhibited AChE. Organophosphates 116-131 acetylcholinesterase Cavia porcellus 147-151 22202465-5 2011 Plasma and brain cholinesterase activities were measured by electrometry after in vivo and in vitro exposure to organophosphates. Organophosphates 112-128 butyrylcholinesterase Homo sapiens 17-31 21937214-1 2011 This paper reports site-specific affinity immobilization of (His)6-tagged acetylcholinesterase (AChE) onto Ni/NiO nanoparticles for the development of an electrochemical screen-printed biosensor for the detection of organophosphate pesticides. Organophosphates 216-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 21937214-1 2011 This paper reports site-specific affinity immobilization of (His)6-tagged acetylcholinesterase (AChE) onto Ni/NiO nanoparticles for the development of an electrochemical screen-printed biosensor for the detection of organophosphate pesticides. Organophosphates 216-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 22129396-1 2011 Acetylcholinesterase (AChE), encoded by the Ace gene, is the primary target of organophosphates (OPs) and carbamates (CBs) in insects. Organophosphates 79-95 neuroligin-4, Y-linked Musca domestica 0-20 22844387-3 2011 Enzymatic activities of SMP30 include aldonolactone and organophosphate hydrolysis. Organophosphates 56-71 regucalcin Homo sapiens 24-29 22129396-1 2011 Acetylcholinesterase (AChE), encoded by the Ace gene, is the primary target of organophosphates (OPs) and carbamates (CBs) in insects. Organophosphates 79-95 LOW QUALITY PROTEIN: angiotensin-converting enzyme Meleagris gallopavo 0-3 21571001-1 2011 Dichlorvos (DDVP) causes neurotoxicity primarily by inhibiting cholinesterase (ChE) which is the characteristic feature of organophosphate pesticides. Organophosphates 123-138 butyrylcholinesterase Rattus norvegicus 63-77 21571001-1 2011 Dichlorvos (DDVP) causes neurotoxicity primarily by inhibiting cholinesterase (ChE) which is the characteristic feature of organophosphate pesticides. Organophosphates 123-138 butyrylcholinesterase Rattus norvegicus 79-82 21907274-0 2011 Organophosphate pesticides increase the expression of alpha glutathione S-transferase in HepG2 cells. Organophosphates 0-15 glutathione S-transferase kappa 1 Homo sapiens 60-85 21968025-7 2011 Our results provide some of the first evidence for a mechanistic relationship between developmental organophosphate exposure and the genes known to confer PD risk in humans; but they also point to disparities between different organophosphates that reinforce the concept that their neurotoxic actions do not rest solely on their shared property as cholinesterase inhibitors. Organophosphates 100-115 butyrylcholinesterase Homo sapiens 348-362 21983245-0 2011 Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study. Organophosphates 108-123 butyrylcholinesterase Homo sapiens 73-94 21983245-1 2011 Organophosphate (OP) compounds exert inhibition on cholinesterase (ChE) activity by irreversibly binding to the catalytic site of the enzyme. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 51-65 21983245-1 2011 Organophosphate (OP) compounds exert inhibition on cholinesterase (ChE) activity by irreversibly binding to the catalytic site of the enzyme. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 67-70 21381051-5 2011 ToxCast assay endpoints related to acetylcholinesterase (AChE) inhibition had low sensitivity for detecting organophosphate pesticides but good sensitivity for detecting N-methyl carbamates. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 22077242-2 2011 The cholinergic toxidrome, resulting from cholinesterase inhibition, is the clinically relevant endpoint in organophosphate poisoning. Organophosphates 108-123 butyrylcholinesterase Homo sapiens 42-56 21930118-0 2011 Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 21945623-1 2011 Several organophosphate triesters are widely used as flame retardants and can be metabolized to dibutyl (DBP), diphenyl (DPhP), di(2-ethylhexyl) (DEHP) and di(1,3-dichloro-2-propyl) (or bis(1,3-dichloro-2-propyl); DDCPP) phosphoric acid, respectively. Organophosphates 8-23 D-box binding PAR bZIP transcription factor Rattus norvegicus 105-108 21478292-0 2011 Benefits of butyrylcholinesterase reactivability testing in organophosphate poisoning. Organophosphates 60-75 butyrylcholinesterase Homo sapiens 12-33 21381051-5 2011 ToxCast assay endpoints related to acetylcholinesterase (AChE) inhibition had low sensitivity for detecting organophosphate pesticides but good sensitivity for detecting N-methyl carbamates. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 22028673-8 2011 Remarkably, the truncated allele of CHKov1 has previously been found to confer resistance to organophosphate insecticides. Organophosphates 93-108 CHK domain ov1 Drosophila melanogaster 36-42 22086792-1 2011 BACKGROUND: Inhibition studies on PON1 as an organophosphate-hydrolyzing and atheroprotective enzyme could be useful in elucidating the function of PON1. Organophosphates 45-60 paraoxonase 1 Homo sapiens 34-38 22086792-1 2011 BACKGROUND: Inhibition studies on PON1 as an organophosphate-hydrolyzing and atheroprotective enzyme could be useful in elucidating the function of PON1. Organophosphates 45-60 paraoxonase 1 Homo sapiens 148-152 21802514-1 2011 Human butyrylcholinesterase (BChE) can scavenge and thereby provide protection against various toxic esters, including organophosphate-based chemical warfare agents and the recreational drug cocaine. Organophosphates 119-134 butyrylcholinesterase Homo sapiens 6-27 21802514-1 2011 Human butyrylcholinesterase (BChE) can scavenge and thereby provide protection against various toxic esters, including organophosphate-based chemical warfare agents and the recreational drug cocaine. Organophosphates 119-134 butyrylcholinesterase Homo sapiens 29-33 21864557-0 2011 Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases. Organophosphates 32-47 paraoxonase 1 Homo sapiens 8-21 21864557-0 2011 Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases. Organophosphates 32-47 paraoxonase 1 Homo sapiens 23-27 21864557-3 2011 Environmental poisoning by organophosphate compounds has been the main driving force of previous research on PON1 enzymes. Organophosphates 27-42 paraoxonase 1 Homo sapiens 109-113 21668653-1 2011 Protection of the enzyme acetylcholinesterase (AChE) from the toxic effects of organophosphate insecticides and chemical warfare agents (OPs) may be provided by inhibitors that bind at the peripheral binding site (P-site) near the mouth of the active-site gorge. Organophosphates 79-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 21668653-1 2011 Protection of the enzyme acetylcholinesterase (AChE) from the toxic effects of organophosphate insecticides and chemical warfare agents (OPs) may be provided by inhibitors that bind at the peripheral binding site (P-site) near the mouth of the active-site gorge. Organophosphates 79-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 21786069-7 2011 We will then discuss the enzyme PON-1 and its potential role in organophosphate insecticide metabolism and toxicity. Organophosphates 64-79 paraoxonase 1 Homo sapiens 32-37 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 21752626-0 2011 Controlled immobilization of acetylcholinesterase on improved hydrophobic gold nanoparticle/Prussian blue modified surface for ultra-trace organophosphate pesticide detection. Organophosphates 139-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 22058655-1 2011 Plasma and brain cholinesterase activities were determined in three wild bird species to assess their exposure to organophosphate and carbamate insecticides which are used in agriculture and public health. Organophosphates 114-129 cholinesterase Columba livia 17-31 22058655-6 2011 The technique of in vitro cholinesterase inhibition for 10 minutes by the organophosphate insecticides dichlorvos, malathion and monocrotophos (0.5 and 1.0 microM) and the carbamate insecticide carbaryl (5 and10 microM) in the enzyme reaction mixtures showed significant inhibition of plasma and whole brain cholinesterase activities to various extents. Organophosphates 74-89 cholinesterase Columba livia 26-40 21975240-3 2011 The enzyme paraoxonase-1 (PON1), part of high density lipoprotein (HDL), had been studied only for its ability to hydrolyze organophosphate derivatives. Organophosphates 124-139 paraoxonase 1 Homo sapiens 11-24 21730071-0 2011 Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. Organophosphates 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 99-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 99-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 21507778-2 2011 Paraoxonase 1 (PON1) is a key enzyme in the metabolism of organophosphates. Organophosphates 58-74 paraoxonase 1 Homo sapiens 0-13 21507778-2 2011 Paraoxonase 1 (PON1) is a key enzyme in the metabolism of organophosphates. Organophosphates 58-74 paraoxonase 1 Homo sapiens 15-19 21975240-3 2011 The enzyme paraoxonase-1 (PON1), part of high density lipoprotein (HDL), had been studied only for its ability to hydrolyze organophosphate derivatives. Organophosphates 124-139 paraoxonase 1 Homo sapiens 26-30 21747136-9 2011 Acetylcholinesterase is inhibited by the nerve gas sarin and by organophosphate pesticides. Organophosphates 64-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21493754-10 2011 Protein expression of ACHE nonsynonymous variant D134H (SNP6) is impaired: this variant shows compromised stability and altered rates of organophosphate inhibition and oxime-assisted reactivation. Organophosphates 137-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). Organophosphates 140-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 21679767-1 2011 Age-related differences in the acute neurotoxicity of cholinesterase (ChE)-inhibiting pesticides have been well-studied for a few organophosphates, but not for many others. Organophosphates 130-146 butyrylcholinesterase Rattus norvegicus 54-68 21679767-1 2011 Age-related differences in the acute neurotoxicity of cholinesterase (ChE)-inhibiting pesticides have been well-studied for a few organophosphates, but not for many others. Organophosphates 130-146 butyrylcholinesterase Rattus norvegicus 70-73 21514816-0 2011 Oxidative desorption of thiocholine assembled on core-shell Fe3O4/AuNPs magnetic nanocomposites for highly sensitive determination of acetylcholinesterase activity: an exposure biomarker of organophosphates. Organophosphates 190-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 103-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 103-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 121-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 121-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21676238-5 2011 Decontamination of the patient"s skin and the removal of the patient"s clothes are mandatory in order to avoid recontamination of the patient as well as the surrounding healthcare personnel.Plasma pseudocholinesterase analysis is a cheap and an easy indicator for organophosphate insecticides intoxications and could be used for diagnosis and treatment monitoring. Organophosphates 264-279 butyrylcholinesterase Homo sapiens 197-217 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 40-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 40-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 21601034-4 2011 Based on the inhibition of OPs on the enzymatic activity of the immobilized AChE, and used carbaryl as the model compound, the resulting biosensor exhibits excellent performance for OPs detection including good reproducibility, acceptable stability, and a reliable linear relationship between the inhibition and log[carbaryl] from 2 ng mL-1 up to 2 mug mL-1 with a detection limit of 0.7 ng mL-1,which provides a new promising tool for analysis of enzyme inhibitors. Organophosphates 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 21382014-0 2011 The crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate inactivation. Organophosphates 161-176 AKO65_RS09910 Bacillus pumilus 77-85 21382471-0 2011 In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates. Organophosphates 73-89 paraoxonase 1 Homo sapiens 21-34 21419823-0 2011 Lipid peroxidation, oxidative stress and acetylcholinesterase in rat brain exposed to organophosphate and pyrethroid insecticides. Organophosphates 86-101 acetylcholinesterase Rattus norvegicus 41-61 21382471-1 2011 Paraoxonase 1 (PON1) has been described as a potential catalytic bioscavenger due to its ability to hydrolyze organophosphate (OP) insecticides and nerve agents. Organophosphates 110-125 paraoxonase 1 Homo sapiens 0-13 21382471-1 2011 Paraoxonase 1 (PON1) has been described as a potential catalytic bioscavenger due to its ability to hydrolyze organophosphate (OP) insecticides and nerve agents. Organophosphates 110-125 paraoxonase 1 Homo sapiens 15-19 21575287-1 2011 INTRODUCTION: Acetylcholinesterase inhibition by organophosphorus pesticides or organophosphate nerve agents can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. Organophosphates 80-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 21481580-1 2011 A new sandwich-like electrochemical immunosensor has been developed for quantification of organophosphorylated acetylcholinesterase (OP-AChE), an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 168-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 21481580-1 2011 A new sandwich-like electrochemical immunosensor has been developed for quantification of organophosphorylated acetylcholinesterase (OP-AChE), an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 168-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 21310461-3 2011 The organophosphate pesticide propetamphos (PPT) has been found exceeding regulatory limits (100 ng L(-1)) in rivers. Organophosphates 4-19 tachykinin precursor 1 Homo sapiens 44-47 21504805-1 2011 A sandwich enzyme-linked immunosorbent assay (sELISA) has been developed for detection of organophosphorylated butyrylcholinesterase (OP-BChE), a potential biomarker for human exposure to organophosphate insecticides and nerve agents. Organophosphates 188-203 butyrylcholinesterase Homo sapiens 111-141 21238577-0 2011 The kinetic study of the inhibition of human cholinesterases by demeton-S-methyl shows that cholinesterase-based titration methods are not suitable for this organophosphate. Organophosphates 157-172 butyrylcholinesterase Homo sapiens 45-59 21291901-0 2011 Paraoxonase-1 genetic polymorphisms and susceptibility to DNA damage in workers occupationally exposed to organophosphate pesticides. Organophosphates 106-121 paraoxonase 1 Homo sapiens 0-13 21291901-1 2011 Human paraoxonase 1 (PON1) is a lipoprotein-associated enzyme involved in the detoxification of organophosphate pesticides (OPs) by hydrolyzing the bioactive oxons. Organophosphates 96-111 paraoxonase 1 Homo sapiens 6-19 21291901-1 2011 Human paraoxonase 1 (PON1) is a lipoprotein-associated enzyme involved in the detoxification of organophosphate pesticides (OPs) by hydrolyzing the bioactive oxons. Organophosphates 96-111 paraoxonase 1 Homo sapiens 21-25 20581384-1 2011 OBJECTIVES: To provide toxicokinetic and clinical evidence of the hydrolytic effect of paraoxonase-1 (PON1) on acute organophosphate poisoning in rats. Organophosphates 117-132 paraoxonase 1 Rattus norvegicus 87-100 20581384-1 2011 OBJECTIVES: To provide toxicokinetic and clinical evidence of the hydrolytic effect of paraoxonase-1 (PON1) on acute organophosphate poisoning in rats. Organophosphates 117-132 paraoxonase 1 Rattus norvegicus 102-106 21448269-2 2011 Among them, the insensitive acetylcholinesterase (ace-1(R) allele) is widespread worldwide and confers cross-resistance to organophosphates and carbamates. Organophosphates 123-139 acetylcholinesterase Culex quinquefasciatus 28-48 20946535-6 2011 CONCLUSION: Extensive preclinical safety and pharmacokinetic testing confirmed that this hBChE preparation can be used for further efficacy testing as a bioscavenger for toxic organophosphate compounds in appropriate animal models and ultimately in humans. Organophosphates 176-191 butyrylcholinesterase Homo sapiens 89-94 21237238-1 2011 A variety of chemicals, such as organophosphate (OP) and carbamate pesticides, nerve agents, and industrial chemicals, inhibit acetylcholinesterase (AChE) leading to overstimulation of the cholinergic nervous system. Organophosphates 32-47 acetylcholinesterase Rattus norvegicus 127-147 21219877-1 2011 Human paraoxonase 1 (PON1) has been portrayed as a catalytic bioscavenger which can hydrolyze large amounts of chemical warfare nerve agents (CWNAs) and organophosphate (OP) pesticides compared to the stoichiometric bioscavengers such as butyrylcholinesterase. Organophosphates 153-168 paraoxonase 1 Homo sapiens 6-19 21219877-1 2011 Human paraoxonase 1 (PON1) has been portrayed as a catalytic bioscavenger which can hydrolyze large amounts of chemical warfare nerve agents (CWNAs) and organophosphate (OP) pesticides compared to the stoichiometric bioscavengers such as butyrylcholinesterase. Organophosphates 153-168 paraoxonase 1 Homo sapiens 21-25 21237238-1 2011 A variety of chemicals, such as organophosphate (OP) and carbamate pesticides, nerve agents, and industrial chemicals, inhibit acetylcholinesterase (AChE) leading to overstimulation of the cholinergic nervous system. Organophosphates 32-47 acetylcholinesterase Rattus norvegicus 149-153 20888407-1 2011 Although organophosphate (OP)-induced acetylcholinesterase (AChE) inhibition is the critical mechanism causing toxicities that follow exposure, other biochemical events, including oxidative stress, have been reported to contribute to OP toxicity. Organophosphates 9-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 21388916-0 2011 Frequencies of organophosphate resistance-associated mutations in the acetylcholinesterase gene of field collected olive fly (Bactrocera oleae) populations under different insecticide regimes. Organophosphates 15-30 acetylcholinesterase Bactrocera oleae 70-90 21388916-1 2011 In the present study, the frequencies of three organophosphate (OP) resistance-associated mutations in acetylcholinesterase gene of Bactrocera oleae (BoAce) populations collected from 8 different important olivegrowing areas in the west part of Turkey were determined. Organophosphates 47-62 acetylcholinesterase Bactrocera oleae 103-123 20839225-1 2011 Paraoxonase 1 (PON1) prevents oxidation of low-density lipoproteins and inactivates toxic oxon derivatives of organophosphate pesticides (OPs). Organophosphates 110-125 paraoxonase 1 Homo sapiens 0-13 20839225-1 2011 Paraoxonase 1 (PON1) prevents oxidation of low-density lipoproteins and inactivates toxic oxon derivatives of organophosphate pesticides (OPs). Organophosphates 110-125 paraoxonase 1 Homo sapiens 15-19 21112395-0 2011 Altered GPI modification of insect AChE improves tolerance to organophosphate insecticides. Organophosphates 62-77 acetylcholinesterase Bactrocera oleae 35-39 21366969-1 2011 This study has investigated the effect of two highly toxic pesticides, monocrotophos (organophosphate) and endosulphan (organochlorine), on the inducibility of two major heat shock proteins, the HSP60 and HSP70, essential for cell survival, in the house fly Musca domestica. Organophosphates 86-101 heat shock 70 kDa protein cognate 4 Musca domestica 205-210 20963445-10 2011 The AChE enzyme obtained by this method could be used to detect the organophosphate and carbamate insecticide residues in fruits and vegetables, a characteristic of great potential research and industrial application. Organophosphates 68-83 neuroligin-4, Y-linked Musca domestica 4-8 20921272-10 2011 The interaction between handling diazinon concentrate and PON1 genotype supports the conclusion that organophosphates may cause DF. Organophosphates 101-117 serum paraoxonase/arylesterase 1 Ovis aries 58-62 21064131-1 2011 This study is aimed at understanding the hydrolysis mechanism of organophosphate (OP) compounds by G117H-BChE. Organophosphates 65-80 butyrylcholinesterase Homo sapiens 105-109 20803562-4 2011 The HIRMAb part of the fusion protein enables brain penetration of the PON1, which was considered important, because organophosphate toxicity causes death via a central nervous system site of action. Organophosphates 117-132 paraoxonase 1 Homo sapiens 71-75 20934178-2 2011 By far the most-studied member is PON1, a high-density lipoprotein-associated esterase/lactonase, also endowed with the capacity to hydrolyze organophosphates, but all the three proteins prevent oxidative stress and fight inflammation. Organophosphates 142-158 paraoxonase 1 Homo sapiens 34-38 21123122-1 2011 Human serum paraoxonase 1 (PON1) is a HDL-associated enzyme that catalyzes the hydrolysis of a variety of aromatic carboxylic acid esters and several organophosphates. Organophosphates 150-166 paraoxonase 1 Homo sapiens 12-25 21673941-0 2011 In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Organophosphates 247-262 butyrylcholinesterase Homo sapiens 71-85 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Organophosphates 247-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21123122-1 2011 Human serum paraoxonase 1 (PON1) is a HDL-associated enzyme that catalyzes the hydrolysis of a variety of aromatic carboxylic acid esters and several organophosphates. Organophosphates 150-166 paraoxonase 1 Homo sapiens 27-31 20967607-5 2011 LE-PCR is illustrated for polymorphisms in human paraoxonase 1 (PON1) that have been shown to affect transcriptional activity and substrate specificity in the detoxification of organophosphates. Organophosphates 177-193 paraoxonase 1 Homo sapiens 49-62 21748880-1 2011 BACKGROUND: Toxicity of organophosphate insecticides is mainly due to the inhibition of acetylcholinesterase (AChE). Organophosphates 24-39 acetylcholinesterase Rattus norvegicus 88-108 21748880-1 2011 BACKGROUND: Toxicity of organophosphate insecticides is mainly due to the inhibition of acetylcholinesterase (AChE). Organophosphates 24-39 acetylcholinesterase Rattus norvegicus 110-114 20967607-5 2011 LE-PCR is illustrated for polymorphisms in human paraoxonase 1 (PON1) that have been shown to affect transcriptional activity and substrate specificity in the detoxification of organophosphates. Organophosphates 177-193 paraoxonase 1 Homo sapiens 64-68 21432054-3 2011 Because of its physiological role, Ache has long been considered a highly specific biomarker for organisms exposed to anticholinesterasic agents, primarily agro-chemicals (organophosphate and carbamate pesticides). Organophosphates 172-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 21712782-2 2011 Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents). Organophosphates 83-99 acetylcholinesterase (Yt blood group) Sus scrofa 35-39 22145061-6 2011 Plasma cholinesterase activity in blood specimens obtained from farm workers was measured using spectrophotometry to establish levels of poisoning by organophosphate and/or carbamates. Organophosphates 150-165 butyrylcholinesterase Homo sapiens 7-21 22145061-9 2011 RESULTS: The prevalence of organophosphate poisoning, indicated by cholinesterase activity of 75% or less, was 24.1%. Organophosphates 27-42 butyrylcholinesterase Homo sapiens 67-81 21432054-26 2011 The potential for ChE inhibition to be applied as an effective parameter of toxicity to detect for the environmental presence of compounds other than the organo-phosphate and carbamate pesticides, and the limitations associated therewith. Organophosphates 154-170 butyrylcholinesterase Homo sapiens 18-21 21111146-6 2010 Determination of organophosphate pesticide was conducted by measuring their inhibition of BuChE with successful assaying of malathion in insecticide samples with high accuracy and precision. Organophosphates 17-32 butyrylcholinesterase Homo sapiens 90-95 20488557-1 2010 The PON1 gene, previously found associated with autism spectrum disorders (ASDs), encodes a serum protein responsible for the detoxification of organophosphates (OPs) and able to exert several enzymatic activities. Organophosphates 144-160 paraoxonase 1 Homo sapiens 4-8 20488557-1 2010 The PON1 gene, previously found associated with autism spectrum disorders (ASDs), encodes a serum protein responsible for the detoxification of organophosphates (OPs) and able to exert several enzymatic activities. Organophosphates 162-165 paraoxonase 1 Homo sapiens 4-8 20122908-1 2010 Serum paraoxonase (PON1) is well recognized for its ability to hydrolyze arylesters, toxic oxon metabolites of organophosphate insecticides and nerve agents. Organophosphates 111-126 paraoxonase 1 Homo sapiens 19-23 21040699-1 2010 Paraoxonase 1 (PON1) has been described as an efficient catalytic bioscavenger due to its ability to hydrolyze organophosphates (OPs) and chemical warfare nerve agents (CWNAs). Organophosphates 111-127 paraoxonase 1 Homo sapiens 0-13 21040699-1 2010 Paraoxonase 1 (PON1) has been described as an efficient catalytic bioscavenger due to its ability to hydrolyze organophosphates (OPs) and chemical warfare nerve agents (CWNAs). Organophosphates 111-127 paraoxonase 1 Homo sapiens 15-19 21126941-1 2010 BACKGROUND: Paraoxonase 1 (PON1) detoxifies oxon derivatives of some organophosphate (OP) pesticides, and its genetic polymorphisms influence enzyme activity and quantity. Organophosphates 69-84 paraoxonase 1 Homo sapiens 12-25 21126941-1 2010 BACKGROUND: Paraoxonase 1 (PON1) detoxifies oxon derivatives of some organophosphate (OP) pesticides, and its genetic polymorphisms influence enzyme activity and quantity. Organophosphates 69-84 paraoxonase 1 Homo sapiens 27-31 21031563-3 2010 Paraoxonase 1 (PON1) is the responsible enzyme for deactivation of organophosphates (OP) in the central nervous system. Organophosphates 67-83 paraoxonase 1 Homo sapiens 0-13 21031563-3 2010 Paraoxonase 1 (PON1) is the responsible enzyme for deactivation of organophosphates (OP) in the central nervous system. Organophosphates 67-83 paraoxonase 1 Homo sapiens 15-19 20529763-1 2010 BACKGROUND: Organophosphate pesticides act as cholinesterase inhibitors. Organophosphates 12-27 butyrylcholinesterase Homo sapiens 46-60 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 0-16 butyrylcholinesterase Homo sapiens 142-146 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 18-21 butyrylcholinesterase Homo sapiens 142-146 21126941-0 2010 PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Organophosphates 73-88 paraoxonase 1 Homo sapiens 0-4 21118365-1 2010 Plasma paraoxonase (PON) is an enzyme that hydrolyzes organic phosphate and aromatic carboxylic acid esters. Organophosphates 54-71 paraoxonase 1 Homo sapiens 7-18 21118365-1 2010 Plasma paraoxonase (PON) is an enzyme that hydrolyzes organic phosphate and aromatic carboxylic acid esters. Organophosphates 54-71 paraoxonase 1 Homo sapiens 20-23 20691716-0 2010 Interaction between organophosphate pesticide exposure and PON1 activity on thyroid function. Organophosphates 20-35 paraoxonase 1 Homo sapiens 59-63 20691716-3 2010 Moreover, the paraoxonase-1 enzyme (PON1) plays an important role in the toxicity of some organophosphate pesticides, with low PON1 activity being associated with higher pesticide sensitivity. Organophosphates 90-105 paraoxonase 1 Homo sapiens 14-27 20691716-3 2010 Moreover, the paraoxonase-1 enzyme (PON1) plays an important role in the toxicity of some organophosphate pesticides, with low PON1 activity being associated with higher pesticide sensitivity. Organophosphates 90-105 paraoxonase 1 Homo sapiens 36-40 20691716-3 2010 Moreover, the paraoxonase-1 enzyme (PON1) plays an important role in the toxicity of some organophosphate pesticides, with low PON1 activity being associated with higher pesticide sensitivity. Organophosphates 90-105 paraoxonase 1 Homo sapiens 127-131 20691716-12 2010 These results suggest a stronger association between organophosphate pesticides and thyroid function in individuals with lower PON1 activity. Organophosphates 53-68 paraoxonase 1 Homo sapiens 127-131 20545876-11 2010 We hypothesize that AtPAP12 and AtPAP26 facilitate Pi scavenging from soil-localized organophosphates during nutritional Pi deprivation. Organophosphates 85-101 purple acid phosphatase 12 Arabidopsis thaliana 20-27 20545876-11 2010 We hypothesize that AtPAP12 and AtPAP26 facilitate Pi scavenging from soil-localized organophosphates during nutritional Pi deprivation. Organophosphates 85-101 purple acid phosphatase 26 Arabidopsis thaliana 32-39 20670621-3 2010 Since paraoxonase enzyme (PON) is a bioscavenger against both atherosclerosis and organophosphate toxicity, studies on paraoxonase enzyme (PON) occupy an important place in the scientific world. Organophosphates 82-97 paraoxonase 1 Homo sapiens 26-29 20701988-1 2010 Organophosphate pesticides (OPs) are environmental toxicants known to inhibit the catalytic activity of acetylcholinesterase (AChE) resulting in hypercholinergic toxicity symptoms. Organophosphates 0-15 acetylcholinesterase Danio rerio 104-124 20701988-1 2010 Organophosphate pesticides (OPs) are environmental toxicants known to inhibit the catalytic activity of acetylcholinesterase (AChE) resulting in hypercholinergic toxicity symptoms. Organophosphates 0-15 acetylcholinesterase Danio rerio 126-130 20303930-1 2010 Fluorogenic organophosphate inhibitors of acetylcholinesterase (AChE) homologous in structure to nerve agents provide useful probes for high throughput screening of mammalian paraoxonase (PON1) libraries generated by directed evolution of an engineered PON1 variant with wild-type like specificity (rePON1). Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 20303930-1 2010 Fluorogenic organophosphate inhibitors of acetylcholinesterase (AChE) homologous in structure to nerve agents provide useful probes for high throughput screening of mammalian paraoxonase (PON1) libraries generated by directed evolution of an engineered PON1 variant with wild-type like specificity (rePON1). Organophosphates 12-27 paraoxonase 1 Homo sapiens 188-192 20303930-1 2010 Fluorogenic organophosphate inhibitors of acetylcholinesterase (AChE) homologous in structure to nerve agents provide useful probes for high throughput screening of mammalian paraoxonase (PON1) libraries generated by directed evolution of an engineered PON1 variant with wild-type like specificity (rePON1). Organophosphates 12-27 paraoxonase 1 Homo sapiens 253-257 20338155-10 2010 In the light of these findings AChE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. Organophosphates 110-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 20138030-3 2010 The powerful toxicity of organophosphate poisons is attributed primarily to their potent inhibition of acetylcholinesterase. Organophosphates 25-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 20138030-5 2010 Many organophosphates and carbamates serve as potent insecticides, by selectively inhibiting insect acetylcholinesterase. Organophosphates 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 20144889-2 2010 Organophosphate (OP) chemical warfare agents such as GD exert their toxic effects by inhibiting acetylcholinesterase (AChE) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). Organophosphates 0-15 acetylcholinesterase Callithrix jacchus 96-116 20144889-2 2010 Organophosphate (OP) chemical warfare agents such as GD exert their toxic effects by inhibiting acetylcholinesterase (AChE) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). Organophosphates 0-15 acetylcholinesterase Callithrix jacchus 118-122 20663095-1 2010 BACKGROUND AND OBJECTIVE: Organophosphates and carbamates are potent cholinesterase inhibitors that are widely used as insecticides in agriculture. Organophosphates 26-42 butyrylcholinesterase Homo sapiens 69-83 21133088-0 2010 Detection of organophosphate pesticide using polyaniline and carbon nanotubes composite based on acetylcholinesterase inhibition. Organophosphates 13-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 21133088-1 2010 Acetylcholinesterase (AChE) activity may be useful biomarker for detecting of organophosphate pesticides (OP). Organophosphates 78-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21133088-1 2010 Acetylcholinesterase (AChE) activity may be useful biomarker for detecting of organophosphate pesticides (OP). Organophosphates 78-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21133092-4 2010 The immobilized acetylcholinesterase (AChE), as a model, showed excellent activity to its substrate and provided a quantitative measurement of organophosphate pesticide. Organophosphates 143-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 21133092-4 2010 The immobilized acetylcholinesterase (AChE), as a model, showed excellent activity to its substrate and provided a quantitative measurement of organophosphate pesticide. Organophosphates 143-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 20600679-1 2010 The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress. Organophosphates 35-51 butyrylcholinesterase Rattus norvegicus 108-122 20472422-0 2010 Acetylcholinesterase biosensor design based on carbon nanotube-encapsulated polypyrrole and polyaniline copolymer for amperometric detection of organophosphates. Organophosphates 144-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20498005-1 2010 Organophosphate (OP) compounds are among the most lethal chemical weapons ever developed and are irreversible inhibitors of acetylcholinesterase. Organophosphates 0-15 acetylcholinesterase Rattus norvegicus 124-144 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 187-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 187-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 205-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 205-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 19819864-0 2010 Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Organophosphates 67-82 butyrylcholinesterase Homo sapiens 35-49 20582942-1 2010 Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Organophosphates 126-142 paraoxonase 1 Homo sapiens 28-39 20582942-1 2010 Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Organophosphates 126-142 paraoxonase 1 Homo sapiens 47-51 20582942-1 2010 Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Organophosphates 126-142 paraoxonase 2 Homo sapiens 53-57 20582942-1 2010 Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Organophosphates 126-142 paraoxonase 3 Homo sapiens 63-67 21235118-0 2010 New original in vitro method to assess cholinesterase reactivity in organophosphate poisoning. Organophosphates 68-83 butyrylcholinesterase Homo sapiens 39-53 21235118-1 2010 Assessment of organophosphate poisoning could benefit from a safe, non-expensive, easy to perform, quick (< 1 hour) test, which evaluates the level of cholinesterase activity "in vitro" regarding to the capability of oximes to reactivate OF-blocked cholinesterase. Organophosphates 14-29 butyrylcholinesterase Homo sapiens 154-168 21235118-1 2010 Assessment of organophosphate poisoning could benefit from a safe, non-expensive, easy to perform, quick (< 1 hour) test, which evaluates the level of cholinesterase activity "in vitro" regarding to the capability of oximes to reactivate OF-blocked cholinesterase. Organophosphates 14-29 butyrylcholinesterase Homo sapiens 252-266 19899158-0 2010 Enantioselective interaction with acetylcholinesterase of an organophosphate insecticide fenamiphos. Organophosphates 61-76 acetylcholinesterase Rattus norvegicus 34-54 20510879-1 2010 PON1 is a high density lipoprotein-associated enzyme that plays an important role in organophosphate detoxification and prevention of atherosclerosis. Organophosphates 85-100 paraoxonase 1 Homo sapiens 0-4 20929049-2 2010 Poisoning includes acute cholinergic crisis as a result of AChE inhibition, intermediate syndrome (IMS) due to neuromuscular necrosis and organophosphate-induced delayed neuropathy (OPIDN) due to inhibition of neuropathy target esterase (NTE). Organophosphates 138-153 patatin like phospholipase domain containing 6 Homo sapiens 210-236 20929049-2 2010 Poisoning includes acute cholinergic crisis as a result of AChE inhibition, intermediate syndrome (IMS) due to neuromuscular necrosis and organophosphate-induced delayed neuropathy (OPIDN) due to inhibition of neuropathy target esterase (NTE). Organophosphates 138-153 patatin like phospholipase domain containing 6 Homo sapiens 238-241 19819864-1 2010 OBJECTIVE: To identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides. Organophosphates 139-154 butyrylcholinesterase Homo sapiens 56-70 20045427-1 2010 The paraoxonase 1 (PON1) enzyme prevents low-density lipoprotein oxidation and also detoxifies the oxon derivatives of certain neurotoxic organophosphate (OP) pesticides. Organophosphates 138-153 paraoxonase 1 Homo sapiens 4-17 20188121-0 2010 Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase. Organophosphates 0-16 patatin-like phospholipase domain containing 6 Mus musculus 84-110 20096260-1 2010 Paraoxonase 1 (PON1) is a high-density lipoprotein-associated enzyme that plays an important role in organophosphate detoxification and prevention of atherosclerosis. Organophosphates 101-116 paraoxonase 1 Homo sapiens 0-13 20096260-1 2010 Paraoxonase 1 (PON1) is a high-density lipoprotein-associated enzyme that plays an important role in organophosphate detoxification and prevention of atherosclerosis. Organophosphates 101-116 paraoxonase 1 Homo sapiens 15-19 20188972-6 2010 Presence of an organophosphate pesticide or a nerve agent results in irreversible inhibition of acetylcholinesterase intercepted on the dipstick. Organophosphates 15-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 20045427-1 2010 The paraoxonase 1 (PON1) enzyme prevents low-density lipoprotein oxidation and also detoxifies the oxon derivatives of certain neurotoxic organophosphate (OP) pesticides. Organophosphates 138-153 paraoxonase 1 Homo sapiens 19-23 20380320-0 2010 [Is PAM an effective antidote for organophosphate poisoning? Organophosphates 34-49 peptidylglycine alpha-amidating monooxygenase Homo sapiens 4-7 20002213-0 2010 Extensive gene duplication of acetylcholinesterase associated with organophosphate resistance in the two-spotted spider mite. Organophosphates 67-82 acetylcholinesterase-like Tetranychus urticae 30-50 20113735-3 2010 The biosensor detected paraoxon in the range 0.035-1.38 ppm and can be used to detect other AChE inhibiting organophosphate pesticides. Organophosphates 108-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20058292-1 2010 Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20058292-1 2010 Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19894225-0 2010 Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates. Organophosphates 116-132 acetylcholinesterase-like Tetranychus urticae 0-20 19161234-3 2010 Thus, the interaction of these chemicals with other AChE inhibitors, namely, organophosphate and carbamate insecticides, is of interest. Organophosphates 77-92 Acetylcholine esterase Drosophila melanogaster 52-56 19894225-1 2010 BACKGROUND: In Tetranychus urticae Koch, acetylcholinesterase insensitivity is often involved in organophosphate (OP) and carbamate (CARB) resistance. Organophosphates 97-112 acetylcholinesterase-like Tetranychus urticae 41-61 20221879-1 2010 Several lines of evidence indicate that serum paraoxonase 1 (PON1) acts as an important guardian against cellular damage from oxidized lipids in plasma membrane, in low-density lipoprotein (LDL), against bacterial endotoxin and against toxic agents such as pesticide residues including organophosphates. Organophosphates 286-302 paraoxonase 1 Homo sapiens 46-59 20221870-0 2010 The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Organophosphates 37-52 paraoxonase 1 Mus musculus 79-92 20221879-1 2010 Several lines of evidence indicate that serum paraoxonase 1 (PON1) acts as an important guardian against cellular damage from oxidized lipids in plasma membrane, in low-density lipoprotein (LDL), against bacterial endotoxin and against toxic agents such as pesticide residues including organophosphates. Organophosphates 286-302 paraoxonase 1 Homo sapiens 61-65 19728005-1 2009 The toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Organophosphates 20-36 acetylcholinesterase Rattus norvegicus 81-101 20890554-2 2010 OBJECTIVE: The acetylcholinesterase activity was determined in study participants with a history of organophosphate and carbamate exposure and the most commonly used pesticides were identified in each study area. Organophosphates 100-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 20535264-1 2010 Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. Organophosphates 86-102 paraoxonase 1 Homo sapiens 0-11 20535264-1 2010 Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. Organophosphates 86-102 paraoxonase 1 Homo sapiens 13-16 20641589-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Organophosphates 117-132 butyrylcholinesterase Homo sapiens 25-29 20641589-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Organophosphates 117-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20641640-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Organophosphates 117-132 butyrylcholinesterase Homo sapiens 25-29 20641640-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Organophosphates 117-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 19333137-2 2009 Based on a clinically relevant animal model that used the organophosphate pesticide mevinphos (Mev) as the experimental insult, we reported previously that heat shock protein 70 (HSP70) in RVLM plays a prolife role by ameliorating circulatory depression during brain stem death. Organophosphates 58-73 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 156-177 19333137-2 2009 Based on a clinically relevant animal model that used the organophosphate pesticide mevinphos (Mev) as the experimental insult, we reported previously that heat shock protein 70 (HSP70) in RVLM plays a prolife role by ameliorating circulatory depression during brain stem death. Organophosphates 58-73 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 179-184 19931747-0 2009 Prognostic value of serial serum cholinesterase activities in organophosphate poisoned patients. Organophosphates 62-77 butyrylcholinesterase Homo sapiens 33-47 19730977-11 2009 Activity of cholinesterase enzymes in blood can be utilized as a biomarker for the effect of organophosphates; of the 232 blood cholinesterase results, 94 (40%) were abnormal. Organophosphates 93-109 butyrylcholinesterase Homo sapiens 12-26 19730977-11 2009 Activity of cholinesterase enzymes in blood can be utilized as a biomarker for the effect of organophosphates; of the 232 blood cholinesterase results, 94 (40%) were abnormal. Organophosphates 93-109 butyrylcholinesterase Homo sapiens 128-142 19783488-2 2009 The methodology was based on the analysis of tryptic peptides resulting from inhibited butyrylcholinesterase (BChE) after exposure to pesticides including organophosphates (OPs) and carbamates (CBs). Organophosphates 155-171 butyrylcholinesterase Equus caballus 110-114 19783488-2 2009 The methodology was based on the analysis of tryptic peptides resulting from inhibited butyrylcholinesterase (BChE) after exposure to pesticides including organophosphates (OPs) and carbamates (CBs). Organophosphates 173-176 butyrylcholinesterase Equus caballus 110-114 20147000-2 2010 Eight farmers had 30% to 50% baseline AChE activity, which suggests chronic organophosphate insecticide poisoning. Organophosphates 76-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 19907334-3 2010 METHODS: We examined associations between Parkinson disease and the organophosphates diazinon, chlorpyrifos, and parathion, and the influence of a functional polymorphism at position 55 in the coding region of the PON1 gene (PON1-55). Organophosphates 68-84 paraoxonase 1 Homo sapiens 214-218 19907334-7 2010 RESULTS: Carriers of the variant MM PON1-55 genotype exposed to organophosphates exhibited a greater than 2-fold increase in Parkinson disease risk compared with persons who had the wildtype or heterozygous genotype and no exposure (for diazinon, odds ratio = 2.2 [95% confidence interval = 1.1-4.5]; for chlorpyrifos, 2.6 [1.3-5.4]). Organophosphates 64-80 paraoxonase 1 Homo sapiens 36-40 19907334-10 2010 CONCLUSION: The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering susceptibility factors when studying environmental exposures in Parkinson disease. Organophosphates 89-105 paraoxonase 1 Homo sapiens 51-55 19907334-10 2010 CONCLUSION: The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering susceptibility factors when studying environmental exposures in Parkinson disease. Organophosphates 89-105 paraoxonase 1 Homo sapiens 121-125 21324267-8 2010 We conclude that donepezil protects the brain against diisopropylfluorophosphate-induced effects and that Syt4 mRNA upregulation may serve as a novel marker for organophosphate-induced seizures. Organophosphates 161-176 synaptotagmin 4 Rattus norvegicus 106-110 20426971-0 2010 [Changes of pathologic feature and microtubulin associated protein 2 in nervous system of hens with organophosphate-induced delayed neuropathy induced by 2,4,6-trimethylbenzoyl phenylphosphonate]. Organophosphates 100-115 microtubule associated protein 2 Gallus gallus 35-68 20426971-1 2010 OBJECTIVE: To develop the organophosphate-induced delayed neuropathy (OPIDN) hen model with 2,4,6-trimethylbenzoyl phenylphosphonate (TOCP), and observe the change of pathology and investigate the alterations of microtubulin associated protein 2 (MAP2). Organophosphates 26-41 microtubule associated protein 2 Gallus gallus 212-245 20426971-1 2010 OBJECTIVE: To develop the organophosphate-induced delayed neuropathy (OPIDN) hen model with 2,4,6-trimethylbenzoyl phenylphosphonate (TOCP), and observe the change of pathology and investigate the alterations of microtubulin associated protein 2 (MAP2). Organophosphates 26-41 microtubule associated protein 2 Gallus gallus 247-251 19735718-1 2009 The main aim of this study was to determine whether sub-lethal concentrations of the organophosphate compound phenyl saligenin phosphate (PSP) could disrupt the activity of the Ca(2+)-activated enzyme tissue transglutaminase (TGase 2) from cultured cell lines of neuronal (N2a) and hepatic (HepG2) origin. Organophosphates 85-100 transglutaminase 2 Homo sapiens 226-233 19735718-7 2009 We suggest that TGase 2 represents a potential target of organophosphate toxicity and that its response may vary in different cellular environments, possibly affected by its expression pattern. Organophosphates 57-72 transglutaminase 2 Homo sapiens 16-23 19922610-1 2009 BACKGROUND: Serum paraoxonase (PON1) is a high density lipoprotein (HDL)-associated enzyme involved in organophosphate (OP) degradation and prevention of atherosclerosis. Organophosphates 103-118 paraoxonase 1 Homo sapiens 31-35 19565307-2 2009 Inhibitors of acetylcholinesterase (AChE) are used in the treatment of myasthenia gravis, Alzheimer"s disease, and in the prophylaxis of poisoning with organophosphates. Organophosphates 152-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19565307-2 2009 Inhibitors of acetylcholinesterase (AChE) are used in the treatment of myasthenia gravis, Alzheimer"s disease, and in the prophylaxis of poisoning with organophosphates. Organophosphates 152-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 19728005-1 2009 The toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Organophosphates 20-36 acetylcholinesterase Rattus norvegicus 103-107 19651761-1 2009 BACKGROUND: The human paraoxonase (PON1) protein detoxifies certain organophosphates, and the PON1 Q192R polymorphism (rs662) affects PON1 activity. Organophosphates 68-84 paraoxonase 1 Homo sapiens 35-39 19646734-2 2009 Paraoxonase (PON1) detoxifies organophosphates by cleavage of active oxons. Organophosphates 30-46 paraoxonase 1 Homo sapiens 13-17 19481427-2 2009 Organophosphate hydrolase (OPH), an enzyme that catalytically hydrolyzes organophosphates, was used as a model enzyme to demonstrate the utility of lysozyme-mediated silica formation for enzyme stabilization. Organophosphates 73-89 acylaminoacyl-peptide hydrolase Homo sapiens 0-25 19481427-2 2009 Organophosphate hydrolase (OPH), an enzyme that catalytically hydrolyzes organophosphates, was used as a model enzyme to demonstrate the utility of lysozyme-mediated silica formation for enzyme stabilization. Organophosphates 73-89 acylaminoacyl-peptide hydrolase Homo sapiens 27-30 19481427-2 2009 Organophosphate hydrolase (OPH), an enzyme that catalytically hydrolyzes organophosphates, was used as a model enzyme to demonstrate the utility of lysozyme-mediated silica formation for enzyme stabilization. Organophosphates 73-89 lysozyme Homo sapiens 148-156 19481427-5 2009 OPH conjugated to a pH-responsive fluorophore was encapsulated in silica and patterned to a waveguide surface to demonstrate the immobilization strategy for the development of an organophosphate array biodetector. Organophosphates 179-194 acylaminoacyl-peptide hydrolase Homo sapiens 0-3 19942738-2 2009 Of these, PON1 in addition has an efficient esterase activity and can hydrolyze organophosphates. Organophosphates 80-96 paraoxonase 1 Homo sapiens 10-14 19651761-1 2009 BACKGROUND: The human paraoxonase (PON1) protein detoxifies certain organophosphates, and the PON1 Q192R polymorphism (rs662) affects PON1 activity. Organophosphates 68-84 paraoxonase 1 Homo sapiens 94-98 19651761-1 2009 BACKGROUND: The human paraoxonase (PON1) protein detoxifies certain organophosphates, and the PON1 Q192R polymorphism (rs662) affects PON1 activity. Organophosphates 68-84 paraoxonase 1 Homo sapiens 94-98 19750105-0 2009 Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Organophosphates 81-96 butyrylcholinesterase Homo sapiens 6-20 19263097-1 2009 Acetylcholinesterase (AChE) and its mutation recently emerged as a significant research area, due to its resistance against organophosphate and carbamate insecticides. Organophosphates 124-139 Acetylcholine esterase Drosophila melanogaster 0-20 19263097-1 2009 Acetylcholinesterase (AChE) and its mutation recently emerged as a significant research area, due to its resistance against organophosphate and carbamate insecticides. Organophosphates 124-139 Acetylcholine esterase Drosophila melanogaster 22-26 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Organophosphates 118-133 peptidylglycine alpha-amidating monooxygenase Homo sapiens 51-54 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 19778163-5 2009 We measured the AChE activity in blood and related it to clinical features of organophosphate poisoning. Organophosphates 78-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19764241-0 2009 Selective detection of hypertoxic organophosphates pesticides via PDMS composite based acetylcholinesterase-inhibition biosensor. Organophosphates 34-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. Organophosphates 68-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 19759306-2 2009 Mutation of the NTE gene or poisoning by neuropathic organophosphates--chemical inhibitors of NTE--causes distal degeneration of long spinal axons in humans. Organophosphates 53-69 patatin like phospholipase domain containing 6 Homo sapiens 16-19 19759306-2 2009 Mutation of the NTE gene or poisoning by neuropathic organophosphates--chemical inhibitors of NTE--causes distal degeneration of long spinal axons in humans. Organophosphates 53-69 patatin like phospholipase domain containing 6 Homo sapiens 94-97 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. Organophosphates 68-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 19764241-4 2009 The hydrophobic surface based PDMS-PDDAN AuNPs/choline oxidase (ChO)/AChE biosensor (biosensor-1) shows excellent stability and unique selectivity to hypertoxic organophosphate. Organophosphates 161-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 19750105-0 2009 Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Organophosphates 81-96 paraoxonase 1 Homo sapiens 62-66 19750105-1 2009 BACKGROUND: Animal studies have demonstrated that low paraoxonase-1 (PON1) status (i.e., low catalytic efficiency and/or low plasma PON1 activity) is associated with neurotoxic effects after exposure to several organophosphate (OP) insecticides. Organophosphates 211-226 paraoxonase 1 Homo sapiens 54-67 19750105-1 2009 BACKGROUND: Animal studies have demonstrated that low paraoxonase-1 (PON1) status (i.e., low catalytic efficiency and/or low plasma PON1 activity) is associated with neurotoxic effects after exposure to several organophosphate (OP) insecticides. Organophosphates 211-226 paraoxonase 1 Homo sapiens 69-73 19577563-1 2009 Paraoxonase 1 (PON1) is an antiatherogenic enzyme which is also an organophosphate hydrolyzer. Organophosphates 67-82 paraoxonase 1 Homo sapiens 15-19 18998164-0 2009 Clinical findings and cholinesterase levels in children of organophosphates and carbamates poisoning. Organophosphates 59-75 butyrylcholinesterase Homo sapiens 22-36 19577563-1 2009 Paraoxonase 1 (PON1) is an antiatherogenic enzyme which is also an organophosphate hydrolyzer. Organophosphates 67-82 paraoxonase 1 Homo sapiens 0-13 19672401-2 2009 Paraoxonase-1 (PON1), an enzyme associated with high-density lipoprotein particles, participates both in the hydrolysis of oxidized lipids (thus protecting against atherosclerosis) and in the hydrolysis of organophosphates. Organophosphates 206-222 paraoxonase 1 Homo sapiens 0-13 19672401-2 2009 Paraoxonase-1 (PON1), an enzyme associated with high-density lipoprotein particles, participates both in the hydrolysis of oxidized lipids (thus protecting against atherosclerosis) and in the hydrolysis of organophosphates. Organophosphates 206-222 paraoxonase 1 Homo sapiens 15-19 18998164-1 2009 INTRODUCTION: Exposure to organophosphate and carbamate insecticides inhibits cholinesterase activity and interferes with synaptic transmission both centrally and peripherally at muscarinic receptors and nicotinic receptors. Organophosphates 26-41 butyrylcholinesterase Homo sapiens 78-92 18998164-2 2009 The study reported the usefulness of plasma cholinesterase ChE activity assays for diagnosis and the management of organophosphate and carbamate toxicity in children. Organophosphates 115-130 butyrylcholinesterase Homo sapiens 44-58 19446239-0 2009 Relationship between human paraoxonase-1 activity and PON1 polymorphisms in Mexican workers exposed to organophosphate pesticides. Organophosphates 103-118 paraoxonase 1 Homo sapiens 27-40 19446239-0 2009 Relationship between human paraoxonase-1 activity and PON1 polymorphisms in Mexican workers exposed to organophosphate pesticides. Organophosphates 103-118 paraoxonase 1 Homo sapiens 54-58 19446239-1 2009 Paraoxonase-1 (PON1) is a serum enzyme which catalyzes the hydrolysis of organophosphate pesticides. Organophosphates 73-88 paraoxonase 1 Homo sapiens 0-13 19446239-1 2009 Paraoxonase-1 (PON1) is a serum enzyme which catalyzes the hydrolysis of organophosphate pesticides. Organophosphates 73-88 paraoxonase 1 Homo sapiens 15-19 19497409-5 2009 The inhibition and subsequent aging of neuropathy target esterase (NTE) by organophosphate has been proposed to be the initiating event in OPIDN. Organophosphates 75-90 patatin like phospholipase domain containing 6 Homo sapiens 39-65 19497409-5 2009 The inhibition and subsequent aging of neuropathy target esterase (NTE) by organophosphate has been proposed to be the initiating event in OPIDN. Organophosphates 75-90 patatin like phospholipase domain containing 6 Homo sapiens 67-70 19586353-6 2009 We have also tested reactivation of butyrylcholinesterase with the aim to recommend an efficient reactivator, able to perform a "pseudo catalytic" bioscavenger with butyrylcholinesterase, which is developed as new antidote of organophosphate poisonings. Organophosphates 226-241 butyrylcholinesterase Homo sapiens 36-57 19492815-2 2009 As an example, the detection of acetylcholinesterase (AChE) inhibitors such as neurotoxins and organophosphates has implications for neuroscience, drug assessment, pharmaceutical development, and environmental monitoring. Organophosphates 95-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 19492815-2 2009 As an example, the detection of acetylcholinesterase (AChE) inhibitors such as neurotoxins and organophosphates has implications for neuroscience, drug assessment, pharmaceutical development, and environmental monitoring. Organophosphates 95-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 19586353-6 2009 We have also tested reactivation of butyrylcholinesterase with the aim to recommend an efficient reactivator, able to perform a "pseudo catalytic" bioscavenger with butyrylcholinesterase, which is developed as new antidote of organophosphate poisonings. Organophosphates 226-241 butyrylcholinesterase Homo sapiens 165-186 19245810-1 2009 Plasma butyrylcholinesterase (BChE) hydrolyzes ester-containing compounds such as succinylcholine, as well as acting as a scavenger against neurotoxic organophosphates (OPs). Organophosphates 151-167 butyrylcholinesterase Rattus norvegicus 7-28 19368529-1 2009 hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). Organophosphates 63-66 butyrylcholinesterase Homo sapiens 0-5 19368529-1 2009 hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). Organophosphates 63-66 butyrylcholinesterase Homo sapiens 1-5 19368529-1 2009 hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). Organophosphates 63-66 butyrylcholinesterase Homo sapiens 19-40 19368529-1 2009 hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). Organophosphates 68-84 butyrylcholinesterase Homo sapiens 0-5 19368529-1 2009 hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). Organophosphates 68-84 butyrylcholinesterase Homo sapiens 1-5 19368529-1 2009 hBChE [human BChE (butyrylcholinesterase)] naturally scavenges OPs (organophosphates). Organophosphates 68-84 butyrylcholinesterase Homo sapiens 19-40 19424713-0 2009 Cholinesterase activity, pesticide exposure and health impact in a population exposed to organophosphates. Organophosphates 89-105 butyrylcholinesterase Homo sapiens 0-14 19245810-1 2009 Plasma butyrylcholinesterase (BChE) hydrolyzes ester-containing compounds such as succinylcholine, as well as acting as a scavenger against neurotoxic organophosphates (OPs). Organophosphates 169-172 butyrylcholinesterase Rattus norvegicus 7-28 19456290-2 2009 Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. Organophosphates 94-110 butyrylcholinesterase Homo sapiens 58-72 19428953-0 2009 Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis. Organophosphates 99-114 butyrylcholinesterase Homo sapiens 21-42 19349639-2 2009 In sensitive species, organophosphate (OP)-induced delayed neurotoxicity is initiated when NTE is inhibited by > 70% and then aged. Organophosphates 22-37 patatin-like phospholipase domain containing 6 Mus musculus 91-94 19225687-11 2009 Among the workers who had used organophosphates over the ten-day period preceding the examination, 2.9% presented two or more symptoms relating to pesticides and a 20% reduction in cholinesterase. Organophosphates 31-47 butyrylcholinesterase Homo sapiens 181-195 19393187-1 2009 Neuropathy target esterase (NTE) was proposed as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN) and adult hens are the animal model of OPIDN. Organophosphates 90-105 patatin like phospholipase domain containing 6 Gallus gallus 0-26 19393187-1 2009 Neuropathy target esterase (NTE) was proposed as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN) and adult hens are the animal model of OPIDN. Organophosphates 90-105 patatin like phospholipase domain containing 6 Gallus gallus 28-31 19440498-8 2009 CONCLUSIONS: Our results point to underlying mechanisms by which different organophosphates produce disparate neurotoxic outcomes despite their shared property as cholinesterase inhibitors. Organophosphates 75-91 butyrylcholinesterase Rattus norvegicus 163-177 19428926-1 2009 Recently, a dynamically working in vitro model with real-time determination of membrane-bound human acetylcholinesterase (AChE) activity was shown to be a versatile model to investigate oxime-induced reactivation kinetics of organophosphate- (OP) inhibited enzyme. Organophosphates 225-240 acetylcholinesterase Cavia porcellus 100-120 19428926-1 2009 Recently, a dynamically working in vitro model with real-time determination of membrane-bound human acetylcholinesterase (AChE) activity was shown to be a versatile model to investigate oxime-induced reactivation kinetics of organophosphate- (OP) inhibited enzyme. Organophosphates 225-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19135350-0 2009 EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Organophosphates 76-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 19122189-0 2009 Salivary acetylcholinesterase as a biomarker for organophosphate exposure. Organophosphates 49-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 19135476-0 2009 Distribution of PON1 polymorphisms PON1Q192R and PON1L55M among Chinese, Malay and Indian males in Singapore and possible susceptibility to organophosphate exposure. Organophosphates 140-155 paraoxonase 1 Homo sapiens 16-20 19159775-1 2009 This work shows the possibility of combining the high sensitivity of genetically-modified Drosophila melanogaster acetylcholinesterase (B394) with the ability of phosphotriesterase (PTE) to hydrolyse organophosphate compounds, in the aim of developing a biosensor selective to two insecticides of interest: chlorpyrifos and chlorfenvinfos. Organophosphates 200-215 Acetylcholine esterase Drosophila melanogaster 114-134 19367692-1 2009 INTRODUCTION: Exposure to irreversible cholinesterase (ChE)-inhibiting compounds, such as organophosphates may produce neuromuscular dysfunction. Organophosphates 90-106 butyrylcholinesterase Rattus norvegicus 39-53 19367692-1 2009 INTRODUCTION: Exposure to irreversible cholinesterase (ChE)-inhibiting compounds, such as organophosphates may produce neuromuscular dysfunction. Organophosphates 90-106 butyrylcholinesterase Rattus norvegicus 55-58 19130375-2 2009 This paper reports the construction of the gold/mercaptobenzothiazole/polyaniline/acetylcholinesterase/polyvinylacetate (Au/ MBT/PANI/AChE/PVAc) thick-film biosensor for the determination of certain organophosphate pesticide solutions in selected aqueous organic solvent solutions. Organophosphates 199-214 proteinase 3 Homo sapiens 70-128 19059269-1 2009 AIMS: Neuropathy target esterase (NTE) was proposed as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN) in humans and some sensitive animals. Organophosphates 96-111 patatin like phospholipase domain containing 6 Homo sapiens 6-32 18950608-1 2009 Oximes are compounds generally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 100-116 acetylcholinesterase Mus musculus 51-71 18950608-1 2009 Oximes are compounds generally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 100-116 acetylcholinesterase Mus musculus 73-77 18950608-1 2009 Oximes are compounds generally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 118-121 acetylcholinesterase Mus musculus 51-71 18950608-1 2009 Oximes are compounds generally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 118-121 acetylcholinesterase Mus musculus 73-77 19059269-1 2009 AIMS: Neuropathy target esterase (NTE) was proposed as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN) in humans and some sensitive animals. Organophosphates 96-111 patatin like phospholipase domain containing 6 Homo sapiens 34-37 19062296-4 2009 Several different scaffolds capable of inhibiting carboxylesterases have been reported, including organophosphates, carbamates, trifluoromethyl ketone-containing structures (TFKs), and aromatic ethane-1,2-diones. Organophosphates 98-114 carboxylesterase 1 Homo sapiens 50-67 19689278-1 2009 Prophylactic approaches against intoxication with organophosphates (OP)/nerve agents can be based on following principles: keeping acetylcholinesterase (AChE), the key enzyme for toxic action of OP/nerve agents, intact (protection of cholinesterases) is a basic requirement for effective prophylaxis. Organophosphates 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 19519385-8 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans. Organophosphates 223-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19689278-1 2009 Prophylactic approaches against intoxication with organophosphates (OP)/nerve agents can be based on following principles: keeping acetylcholinesterase (AChE), the key enzyme for toxic action of OP/nerve agents, intact (protection of cholinesterases) is a basic requirement for effective prophylaxis. Organophosphates 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 20183530-1 2009 Paraoxonase-1 (PON1) is a serum esterase that hydrolyzes the activated oxon form of several organophosphates. Organophosphates 92-108 paraoxonase 1 Homo sapiens 0-13 19145051-2 2009 Organophosphate compounds cause poisoning, inhibiting acetylcholinesterase at the cholinergic synapses. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 19851039-1 2009 OBJECTIVE: The impact of long term exposure to cholinesterase (ChE)-inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated. Organophosphates 79-94 butyrylcholinesterase Homo sapiens 47-61 19851039-1 2009 OBJECTIVE: The impact of long term exposure to cholinesterase (ChE)-inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated. Organophosphates 79-94 butyrylcholinesterase Homo sapiens 63-66 20183530-1 2009 Paraoxonase-1 (PON1) is a serum esterase that hydrolyzes the activated oxon form of several organophosphates. Organophosphates 92-108 paraoxonase 1 Homo sapiens 15-19 20183530-2 2009 The central role of PON1 in detoxification of organophosphate (OP) pesticides was demonstrated in knockout mouse studies, suggesting that human variability in PON1 needs to be considered in health risk assessments involving exposure to these pesticides. Organophosphates 46-61 paraoxonase 1 Mus musculus 20-24 20183530-2 2009 The central role of PON1 in detoxification of organophosphate (OP) pesticides was demonstrated in knockout mouse studies, suggesting that human variability in PON1 needs to be considered in health risk assessments involving exposure to these pesticides. Organophosphates 46-61 paraoxonase 1 Homo sapiens 159-163 19194505-1 2009 Aphids, among the most destructive insects to world agriculture, are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE). Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 18773955-1 2009 Neonatal exposures to organophosphates that are not acutely symptomatic or that produce little or no cholinesterase inhibition can nevertheless compromise the development and later function of critical neural pathways, including serotonin (5HT) systems that regulate emotional behaviors. Organophosphates 22-38 butyrylcholinesterase Rattus norvegicus 101-115 19194505-1 2009 Aphids, among the most destructive insects to world agriculture, are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE). Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 19434854-1 2008 Paraoxonase (PON)-1 is the most potent human protein with organophosphatase activity against organophosphate (OP) toxins. Organophosphates 93-108 paraoxonase 1 Homo sapiens 0-19 22346715-0 2009 Variation of cholinesterase-based biosensor sensitivity to inhibition by organophosphate due to ionizing radiation. Organophosphates 73-88 butyrylcholinesterase Homo sapiens 13-27 18555561-0 2008 A clinical decision aid for triage of children younger than 5 years and with organophosphate or carbamate insecticide exposure in developing countries. Organophosphates 77-92 activation induced cytidine deaminase Homo sapiens 20-23 20161844-1 2008 PON1 has been demonstrated to be the serum enzyme responsible for detoxifying organophosphate chemical weapons and plays a protective role against atherosclerosis. Organophosphates 78-93 paraoxonase 1 Homo sapiens 0-4 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18855408-1 2008 A new magnetic electrochemical immunoassay has been developed as a tool for biomonitoring exposures to organophosphate (OP) compounds, e.g., insecticides and chemical nerve agents, by directly detecting organophosphorylated acetylcholinesterase (OP-AChE). Organophosphates 103-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-244 18855408-1 2008 A new magnetic electrochemical immunoassay has been developed as a tool for biomonitoring exposures to organophosphate (OP) compounds, e.g., insecticides and chemical nerve agents, by directly detecting organophosphorylated acetylcholinesterase (OP-AChE). Organophosphates 103-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 18762277-4 2008 CES1 is inhibited by oxons, the bioactive metabolites of organophosphate (OP) pesticides. Organophosphates 57-72 carboxylesterase 1 Homo sapiens 0-4 18755237-2 2008 We hypothesized that the homeostasis of lysophosphatidylcholine (LPC) and/or phosphatidylcholine (PC) in nervous tissues might be disrupted after exposure to the organophosphates (OP) which participates in the progression of OPIDN because new clues to possible mechanisms of OPIDN have recently been discovered that NTE acts as lysophospholipase (LysoPLA) in mice and phospholipase B (PLB) in cultured mammalian cells. Organophosphates 162-178 patatin-like phospholipase domain containing 6 Mus musculus 316-319 18755237-2 2008 We hypothesized that the homeostasis of lysophosphatidylcholine (LPC) and/or phosphatidylcholine (PC) in nervous tissues might be disrupted after exposure to the organophosphates (OP) which participates in the progression of OPIDN because new clues to possible mechanisms of OPIDN have recently been discovered that NTE acts as lysophospholipase (LysoPLA) in mice and phospholipase B (PLB) in cultured mammalian cells. Organophosphates 162-178 phospholipase B1 Mus musculus 368-383 18504554-1 2008 Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 110-126 acetylcholinesterase Mus musculus 61-81 18504554-1 2008 Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 110-126 acetylcholinesterase Mus musculus 83-87 18504554-1 2008 Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 128-131 acetylcholinesterase Mus musculus 61-81 18504554-1 2008 Oximes are a class of compounds normally used to reverse the acetylcholinesterase (AChE) inhibition caused by organophosphates (OPs). Organophosphates 128-131 acetylcholinesterase Mus musculus 83-87 18931667-3 2008 An optimized GFP variant fused to PON1 reported levels of soluble, functional enzyme, enabling selection by flow cytometry and identification of enzyme variants exhibiting improved specific and total activities toward several substrates, including toxic organophosphates. Organophosphates 254-270 paraoxonase 1 Homo sapiens 34-38 18804659-0 2008 Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. Organophosphates 52-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 18804659-2 2008 Detection of organophosphates is frequently based on following acetylcholinesterase (AChE) inhibition. Organophosphates 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 18804659-2 2008 Detection of organophosphates is frequently based on following acetylcholinesterase (AChE) inhibition. Organophosphates 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 18941570-1 2008 BACKGROUND: Organophosphates elicit developmental neurotoxicity through multiple mechanisms other than their shared property as cholinesterase inhibitors. Organophosphates 12-28 butyrylcholinesterase Rattus norvegicus 128-142 18514178-0 2008 Increased organophosphate scavenging in a butyrylcholinesterase mutant. Organophosphates 10-25 butyrylcholinesterase Homo sapiens 42-63 18486120-1 2008 Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates. Organophosphates 97-113 butyrylcholinesterase Mus musculus 0-21 18602477-1 2008 Human serum butyrylcholinesterase (Hu BChE) is the most viable candidate for the prophylactic treatment of organophosphate poisoning. Organophosphates 107-122 butyrylcholinesterase Homo sapiens 12-33 18602477-1 2008 Human serum butyrylcholinesterase (Hu BChE) is the most viable candidate for the prophylactic treatment of organophosphate poisoning. Organophosphates 107-122 butyrylcholinesterase Homo sapiens 38-42 18514176-6 2008 Thus, these new strains with the ability to secret R-DmAChE in the medium could be used for production of R-DmAChE to decrease the cost of the enzyme expense for rapid detection of organophosphate and carbamate insecticide residues. Organophosphates 181-196 Acetylcholine esterase Drosophila melanogaster 53-59 18514176-6 2008 Thus, these new strains with the ability to secret R-DmAChE in the medium could be used for production of R-DmAChE to decrease the cost of the enzyme expense for rapid detection of organophosphate and carbamate insecticide residues. Organophosphates 181-196 Acetylcholine esterase Drosophila melanogaster 108-114 18486120-1 2008 Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates. Organophosphates 97-113 butyrylcholinesterase Mus musculus 23-27 18586231-0 2008 Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase. Organophosphates 74-89 butyrylcholinesterase Homo sapiens 105-126 18501341-1 2008 One of the therapeutic approaches to organophosphate poisoning is to reactivate AChE with site-directed nucleophiles such as oximes. Organophosphates 37-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 18579126-2 2008 The action of toxic organophosphates such as nerve agents is based on AChE inhibition. Organophosphates 20-36 acetylcholinesterase Rattus norvegicus 70-74 18597747-1 2008 Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a pretreatment drug for organophosphate (OP) poisoning in humans. Organophosphates 111-126 butyrylcholinesterase Homo sapiens 12-33 18597747-1 2008 Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a pretreatment drug for organophosphate (OP) poisoning in humans. Organophosphates 111-126 butyrylcholinesterase Homo sapiens 38-42 18674756-1 2008 Human serum butyrylcholinesterase (Hu BChE) was demonstrated previously to be an effective prophylaxis that can protect animals from organophosphate nerve agents. Organophosphates 133-148 cholinesterase Macaca fascicularis 12-33 18707125-0 2008 Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase. Organophosphates 56-71 S-formylglutathione hydrolase Saccharomyces cerevisiae S288C 130-159 18674756-1 2008 Human serum butyrylcholinesterase (Hu BChE) was demonstrated previously to be an effective prophylaxis that can protect animals from organophosphate nerve agents. Organophosphates 133-148 cholinesterase Macaca fascicularis 38-42 18468882-0 2008 Development of a bifunctional sensor using haptenized acetylcholinesterase and application for the detection of cocaine and organophosphates. Organophosphates 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18711144-0 2008 Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning. Organophosphates 101-116 paraoxonase 1 Homo sapiens 29-42 18796381-0 2008 Acute toxicity and cholinesterase inhibition in chicks dosed orally with organophosphate insecticides. Organophosphates 73-88 butyrylcholinesterase Homo sapiens 19-33 18796381-9 2008 These data suggest that organophosphate insecticides administered orally at LD50 doses induce clinical signs of cholinergic poisoning and concurrently reduce brain and plasma cholinesterase activities in chicks. Organophosphates 24-39 butyrylcholinesterase Homo sapiens 175-189 18704198-7 2008 PON1 transgenic flies expressed enzymatically active PON1 and thereby exhibited arylesterase activity and resistance to organophosphate toxicity. Organophosphates 120-135 paraoxonase 1 Homo sapiens 0-4 18676153-1 2008 Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21791372-1 2008 Chronic and acute exposure to organophosphate pesticides or related nerve agents may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 175-195 21791372-1 2008 Chronic and acute exposure to organophosphate pesticides or related nerve agents may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 197-201 18704198-7 2008 PON1 transgenic flies expressed enzymatically active PON1 and thereby exhibited arylesterase activity and resistance to organophosphate toxicity. Organophosphates 120-135 paraoxonase 1 Homo sapiens 53-57 18625401-0 2008 A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organophosphate resistance. Organophosphates 91-106 acetylcholinesterase Bactrocera oleae 34-54 18572410-3 2008 PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one. Organophosphates 16-32 paraoxonase 1 Homo sapiens 0-4 18716378-0 2008 Interethnic variability of plasma paraoxonase (PON1) activity towards organophosphates and PON1 polymorphisms among Asian populations--a short review. Organophosphates 70-86 paraoxonase 1 Homo sapiens 47-51 18625401-1 2008 Organophosphate resistance in the olive fly was previously shown to associate with two point mutations in the ace gene. Organophosphates 0-15 acetylcholinesterase Bactrocera oleae 110-113 18577432-1 2008 Serum paraoxonase-1 (PON1) is an esterase associated with high-density lipoproteins in plasma and is involved in the detoxification of organophosphates (OP). Organophosphates 135-151 paraoxonase 1 Rattus norvegicus 21-25 18423506-2 2008 The current report utilized the peripheral anionic site specific fluorogenic probe thioflavin t to determine if the organophosphates chlorpyrifos oxon and dichlorvos bind to the peripheral anionic site of human recombinant acetylcholinesterase, since certain organophosphates display concentration-dependent kinetics when inhibiting this enzyme. Organophosphates 116-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-243 18423506-2 2008 The current report utilized the peripheral anionic site specific fluorogenic probe thioflavin t to determine if the organophosphates chlorpyrifos oxon and dichlorvos bind to the peripheral anionic site of human recombinant acetylcholinesterase, since certain organophosphates display concentration-dependent kinetics when inhibiting this enzyme. Organophosphates 259-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-243 18564794-3 2008 The morbidity and mortality with organophosphate poisoning is relatively high despite the use of atropine as specific antidotal therapy and oximes to reactivate acetylcholinesterase. Organophosphates 33-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 18630983-0 2008 The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka. Organophosphates 54-69 sorcin Homo sapiens 113-116 18472339-2 2008 Sequencing of the amplification products revealed that 8/12 of the diazinon-resistant horn flies contained a point mutation previously associated with resistance to organophosphates in house flies and Drosophila, strongly suggesting that this cDNA encodes the AChE that is the target site for organophosphate (OP) pesticide. Organophosphates 165-181 Acetylcholine esterase Drosophila melanogaster 260-264 18472339-2 2008 Sequencing of the amplification products revealed that 8/12 of the diazinon-resistant horn flies contained a point mutation previously associated with resistance to organophosphates in house flies and Drosophila, strongly suggesting that this cDNA encodes the AChE that is the target site for organophosphate (OP) pesticide. Organophosphates 165-180 Acetylcholine esterase Drosophila melanogaster 260-264 18157496-0 2008 Plasma cholinesterase levels and health symptoms in peruvian farm workers exposed to organophosphate pesticides. Organophosphates 85-100 butyrylcholinesterase Homo sapiens 7-21 18502319-9 2008 Effects in PC12 cells mirrored many of those for members of the fgf, ntf and wnt families, as well as the receptors for the ntfs, especially during early differentiation, the stage known to be most susceptible to disruption by organophosphates. Organophosphates 227-243 Wnt family member 2 Rattus norvegicus 77-80 21783883-1 2008 Chronic and acute exposure to organophosphate pesticides may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 151-171 21783883-1 2008 Chronic and acute exposure to organophosphate pesticides may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 173-177 18564794-6 2008 Adjunct and alternative therapies included treatments to reduce poison absorption by topical application of creams, enhance toxin elimination by haemoperfusion or bioremediation and neutralise the poison by scavenging free organophosphate with cholinesterase-rich human plasma. Organophosphates 223-238 butyrylcholinesterase Homo sapiens 244-258 18661050-1 2008 The neuropathy target esterase is a membrane-bound enzyme linked to organophosphate-induced distal neuropathy. Organophosphates 68-83 patatin like phospholipase domain containing 6 Gallus gallus 4-30 18505017-0 2008 Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 124-139 butyrylcholinesterase Rattus norvegicus 67-81 18505017-9 2008 The dynamics of the ChE enzyme activity in saliva with organophosphate pesticides was further studied using this sensor. Organophosphates 55-70 butyrylcholinesterase Rattus norvegicus 20-23 18355640-5 2008 This pattern differed substantially from that seen in earlier work with another organophosphate, chlorpyrifos, which at pharmacodynamically similar doses spanning the threshold for cholinesterase inhibition, evoked a much more substantial, global upregulation of 5HT receptor expression; with chlorpyrifos, effects on receptors were seen in females, albeit to a lesser extent than in males, and were also regionally distinct. Organophosphates 80-95 butyrylcholinesterase Rattus norvegicus 181-195 18191825-1 2008 Neuropathy target esterase (NTE) was proposed as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN) in human and some sensitive animals. Organophosphates 90-105 patatin like phospholipase domain containing 6 Homo sapiens 0-26 18347314-0 2008 Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS. Organophosphates 21-36 paraoxonase 1 Homo sapiens 0-13 18347314-0 2008 Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS. Organophosphates 21-36 paraoxonase 1 Homo sapiens 15-19 18191825-1 2008 Neuropathy target esterase (NTE) was proposed as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN) in human and some sensitive animals. Organophosphates 90-105 patatin like phospholipase domain containing 6 Homo sapiens 28-31 18335101-9 2008 The patterns seen here differ substantially from those seen in earlier work with chlorpyrifos, reinforcing the concept that the various organophosphates have fundamentally different effects on the developmental trajectories of specific neurotransmitter systems, unrelated to their shared action as cholinesterase inhibitors. Organophosphates 136-152 butyrylcholinesterase Rattus norvegicus 298-312 18207076-0 2008 Alterations of the acetylcholinesterase enzyme in the oriental fruit fly Bactrocera dorsalis are correlated with resistance to the organophosphate insecticide fenitrothion. Organophosphates 131-146 LOW QUALITY PROTEIN: acetylcholinesterase Bactrocera dorsalis 19-39 18207076-1 2008 Alterations of the structure and activity of the enzyme acetylcholinesterase (AChE) leading to resistance to organophosphate insecticides have been examined in the oriental fruit fly, Bactrocera dorsalis (Hendel), an economic pest of great economic importance in the Asia-Pacific region. Organophosphates 109-124 LOW QUALITY PROTEIN: acetylcholinesterase Bactrocera dorsalis 56-76 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Organophosphates 138-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Organophosphates 138-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 18942695-0 2008 Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 131-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 18324340-1 2008 This study aimed to evaluate the antidotal potency of tenocyclidine (TCP) that probably might protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. Organophosphates 145-160 acetylcholinesterase Rattus norvegicus 102-122 18324340-1 2008 This study aimed to evaluate the antidotal potency of tenocyclidine (TCP) that probably might protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. Organophosphates 145-160 acetylcholinesterase Rattus norvegicus 124-128 18942695-1 2008 A nanoparticle-based electrochemical immunosensor has been developed for the detection of phosphorylated acetylcholinesterase (AChE), which is a potential biomarker of exposure to organophosphate (OP) pesticides and chemical warfare nerve agents. Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 18942695-1 2008 A nanoparticle-based electrochemical immunosensor has been developed for the detection of phosphorylated acetylcholinesterase (AChE), which is a potential biomarker of exposure to organophosphate (OP) pesticides and chemical warfare nerve agents. Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 18220560-0 2007 Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents. Organophosphates 80-96 butyrylcholinesterase Homo sapiens 0-14 18167037-9 2008 CONCLUSION: Organophosphate poisoning can cause myocardial injury as determined by measurement of I cTnI levels. Organophosphates 12-27 troponin I3, cardiac type Rattus norvegicus 100-104 18393843-10 2008 Oximes, by reactivating acetylcholinesterase, are important adjunct therapeutics in organophosphate poisoning. Organophosphates 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 18642608-6 2008 PON1 is an enzyme with multiple activities, including detoxification of organophosphates. Organophosphates 72-88 paraoxonase 1 Homo sapiens 0-4 18203274-3 2008 hBChE is primarily involved in neuronal transmission and is a potential bioscavenger of toxic organophosphates to protect acetylcholinesterase. Organophosphates 94-110 butyrylcholinesterase Homo sapiens 0-5 18220560-1 2007 Understanding the mechanism of action of organophosphates (OP)/nerve agents -- irreversible acetylcholinesterase (AChE, EC 3.1.1.7) inhibition at the cholinergic synapses followed by metabolic dysbalance of the organism -- two therapeutic principles for antidotal treatment are derived. Organophosphates 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 18049927-0 2007 Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. Organophosphates 37-52 acylaminoacyl-peptide hydrolase Homo sapiens 141-162 18049927-1 2007 Organophosphate pesticides have been classically described as inhibitors of acetylcholinesterase (AChE) activity in insects and invertebrates. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 18049927-1 2007 Organophosphate pesticides have been classically described as inhibitors of acetylcholinesterase (AChE) activity in insects and invertebrates. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 18049927-3 2007 The enzyme acylpeptide hydrolase was identified as a new target for organophosphate pesticides. Organophosphates 68-83 acylaminoacyl-peptide hydrolase Homo sapiens 11-32 18049927-4 2007 This enzyme is more sensitive than AChE to some organophosphates (OP), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to Alzheimer"s disease. Organophosphates 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17702992-3 2007 However, more recent studies have suggested that the interactions of certain anticholinesterase organophosphates with acetylcholinesterase are more complex than previously thought since their inhibitory capacity has been noted to change as a function of inhibitor concentration. Organophosphates 96-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 17698511-0 2007 Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry. Organophosphates 19-34 butyrylcholinesterase Homo sapiens 51-72 17880043-0 2007 Organophosphate insecticides and acaricides antagonise bifenazate toxicity through esterase inhibition in Tetranychus urticae. Organophosphates 0-15 acetylcholinesterase-like Tetranychus urticae 83-91 17880043-4 2007 RESULTS: Esterase activity determined in vivo after pre-exposure of mites with organophosphates and carbamates revealed--depending on the compound--varying esterase inhibition nicely correlated with the ability of the individual compound to antagonise bifenazate action on mites. Organophosphates 79-95 acetylcholinesterase-like Tetranychus urticae 9-17 17880043-4 2007 RESULTS: Esterase activity determined in vivo after pre-exposure of mites with organophosphates and carbamates revealed--depending on the compound--varying esterase inhibition nicely correlated with the ability of the individual compound to antagonise bifenazate action on mites. Organophosphates 79-95 acetylcholinesterase-like Tetranychus urticae 156-164 17764957-1 2007 Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17370251-0 2007 Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 17924614-1 2007 Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17913405-1 2007 Neuropathy target esterase (NTE) is recognized as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 91-106 patatin like phospholipase domain containing 6 Gallus gallus 0-26 17913405-1 2007 Neuropathy target esterase (NTE) is recognized as the initial target during the process of organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 91-106 patatin like phospholipase domain containing 6 Gallus gallus 28-31 17698511-4 2007 However, some recent studies have indicated that organophosphate-inhibited butyrylcholinesterase (BChE) may age through an alternative pathway. Organophosphates 49-64 butyrylcholinesterase Homo sapiens 75-96 17698511-4 2007 However, some recent studies have indicated that organophosphate-inhibited butyrylcholinesterase (BChE) may age through an alternative pathway. Organophosphates 49-64 butyrylcholinesterase Homo sapiens 98-102 17582755-5 2007 The resulting sensor system detects organophosphates based on either enzyme inhibition (of BuChE) or substrate hydrolysis (by OPH). Organophosphates 36-52 acylaminoacyl-peptide hydrolase Homo sapiens 126-129 17265425-14 2007 The results indicate that brain penetration of 2-PAM is poor and that organophosphates only have a modest effect on 2-PAM BBB penetration. Organophosphates 70-86 peptidylglycine alpha-amidating monooxygenase Rattus norvegicus 118-121 17640809-1 2007 We examined a hypothesis that reactive oxygen species (ROS) generated by organophosphate compound dichlorvos modulates Hsp70 expression and anti-oxidant defense enzymes and acts as a signaling molecule for apoptosis in the exposed organism. Organophosphates 73-88 Heat-shock-protein-70Ab Drosophila melanogaster 119-124 19858641-1 2007 BACKGROUND/AIMS: Paraoxon, an organophosphate metabolite of the insecticide parathion inhibits the enzyme, acetylcholinesterase (Achase). Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 107-127 19858641-1 2007 BACKGROUND/AIMS: Paraoxon, an organophosphate metabolite of the insecticide parathion inhibits the enzyme, acetylcholinesterase (Achase). Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 129-135 17913689-6 2007 Second, through a novel chemistry, termed freeze-frame, click chemistry, we have used organophosphate conjugates of acetylcholinesterase as templates for the synthesis of novel nucleophilic reactivating agents. Organophosphates 86-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 17913689-8 2007 When linked at certain locations in the molecule, the attached fluorophore is sensitive to organophosphate conjugation with acetylcholinesterase, and thus the very target of insecticide or nerve agent action becomes a detection molecule for organophosphate exposure. Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 17913689-8 2007 When linked at certain locations in the molecule, the attached fluorophore is sensitive to organophosphate conjugation with acetylcholinesterase, and thus the very target of insecticide or nerve agent action becomes a detection molecule for organophosphate exposure. Organophosphates 241-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 17475919-3 2007 Inherent AChE-R overproduction under organophosphate intoxication confers both short-term protection (as a bioscavenger) and long-term neuromuscular damages (as a regulator). Organophosphates 37-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 17475919-5 2007 AChE-R(ER) purified to homogeneity showed indistinguishable biochemical properties, with IC50 = 10(-7) M for the organophosphate paraoxon, similar to mammalian cell culture-derived AChE. Organophosphates 113-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17475919-7 2007 By 10 days postexposure, AChE-R prophylaxis markedly limited postexposure increases in plasma murine AChE-R levels while minimizing the organophosphate-induced neuromuscular junction dismorphology. Organophosphates 136-151 acetylcholinesterase Mus musculus 25-29 17475919-8 2007 Our findings present plant-produced AChE-R(ER) as a bimodal agent, conferring both short- and long-term protection from organophosphate intoxication. Organophosphates 120-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 17703881-1 2007 In mice, lysophosphatidylcholine (LPC) was found to be a physiological substrate of neuropathy target esterase, which is also bound by organophosphates that cause a delayed neuropathy in human and some animals. Organophosphates 135-151 patatin-like phospholipase domain containing 6 Mus musculus 84-110 17660298-0 2007 Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Organophosphates 91-106 butyrylcholinesterase Homo sapiens 18-39 17651311-1 2007 Human serum paraoxonase (PON1) is a high-density lipoprotein-associated esterase that protects against organophosphate neurotoxicity, and is proposed to play a role in lipid metabolism and the onset of cardiovascular disease. Organophosphates 103-118 paraoxonase 1 Homo sapiens 25-29 17532308-0 2007 Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects. Organophosphates 83-99 paraoxonase 1 Homo sapiens 0-11 17532308-0 2007 Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects. Organophosphates 83-99 paraoxonase 1 Homo sapiens 13-17 17467020-0 2007 Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase. Organophosphates 44-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 17504354-0 2007 Is there a relationship between the blood cholinesterase and QTc interval in the patients with acute organophosphate poisoning? Organophosphates 101-116 butyrylcholinesterase Homo sapiens 42-56 17504354-1 2007 Organophosphates cause poisoning as a result of the excessive accumulation of acetylcholine at the cholinergic synapses due to inhibition of acetylcholinesterase (ChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 17558807-1 2007 Paraoxonase (PON1) is a serum enzyme that plays an important role in prevention of atherosclerosis and also protects against organophosphate-induced neurotoxicity. Organophosphates 125-140 paraoxonase 1 Homo sapiens 13-17 18085124-3 2007 Organophosphate compounds inhibit acetylcholinesterase resulting in acute toxicity. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 17382909-9 2007 These results in conjunction with previous data with organophosphates and organophosphonates emphasizes the necessity for kinetic studies as basis for future work on structural analysis with human AChE and for the development of effective broad-spectrum oximes. Organophosphates 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 17222583-10 2007 These results suggest that the R-DmAChE can be useful for detection of organophosphate and carbamate insecticide residues. Organophosphates 71-86 Acetylcholine esterase Drosophila melanogaster 33-39 17571671-10 2007 In the German Bight, the river Elbe is the dominating source for the more hydrophilic compounds, such as chlorinated organophosphate flame retardants, which are diluted only into the North Sea. Organophosphates 117-132 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 189-192 17448118-0 2007 Effect of interleukin-10 on tissue damage caused by organophosphate poisoning. Organophosphates 52-67 interleukin 10 Rattus norvegicus 10-24 17452286-1 2007 Organophosphates affect mammalian brain development through a variety of mechanisms beyond their shared property of cholinesterase inhibition. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 116-130 17407327-6 2007 In addition, structural features of the hCE1 active site indicate that the enzyme may be resistant to dead-end organophosphate aging reactions that permanently inactivate other serine hydrolases. Organophosphates 111-126 carboxylesterase 1 Homo sapiens 40-44 17448118-3 2007 We tested whether interleukin-10, a cytoprotective agent, could prevent or diminish pathological signs of tissue damages caused by organophosphate poisoning. Organophosphates 131-146 interleukin 10 Rattus norvegicus 18-32 21957348-1 2007 BACKGROUND: Paraoxonase (PON1) can hydrolyze organophosphate pesticides (OP) and has a key role in the susceptibility of human in OP toxicity. Organophosphates 45-60 paraoxonase 1 Homo sapiens 12-23 21957348-1 2007 BACKGROUND: Paraoxonase (PON1) can hydrolyze organophosphate pesticides (OP) and has a key role in the susceptibility of human in OP toxicity. Organophosphates 45-60 paraoxonase 1 Homo sapiens 25-29 17046138-1 2007 Selected mutagenesis of acetylcholinesterase (AChE; EC 3.1.1.7) may enable one to develop more effective scavenging agents in which AChE itself, in combination with an oxime, will complete a catalytic cycle of hydrolysis of the organophosphate by rapid conjugation followed by enhanced nucleophile-mediated hydrolysis of the phosphonyl enzyme conjugate. Organophosphates 228-243 acetylcholinesterase Mus musculus 24-44 17504181-3 2007 Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function. Organophosphates 33-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 17504181-3 2007 Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function. Organophosphates 33-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 17335779-0 2007 Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates. Organophosphates 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17335779-5 2007 Considering the large size of the human skin with 1.8m(2) surface area with its calcium gradient in the 10(-3)M range, our results implicate calcium-activated BuchE as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue. Organophosphates 235-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 17204329-3 2007 The enzyme paraoxonase 1 (PON1) detoxifies organophosphates and the efficacy of this enzyme varies with polymorphisms in the PON1 gene. Organophosphates 43-59 paraoxonase 1 Homo sapiens 11-24 17204329-3 2007 The enzyme paraoxonase 1 (PON1) detoxifies organophosphates and the efficacy of this enzyme varies with polymorphisms in the PON1 gene. Organophosphates 43-59 paraoxonase 1 Homo sapiens 26-30 17204329-3 2007 The enzyme paraoxonase 1 (PON1) detoxifies organophosphates and the efficacy of this enzyme varies with polymorphisms in the PON1 gene. Organophosphates 43-59 paraoxonase 1 Homo sapiens 125-129 17204329-11 2007 In conclusion, some PON1 promoter polymorphisms may predispose to SALS, possibly by making motor neurons more susceptible to organophosphate-containing toxins. Organophosphates 125-140 paraoxonase 1 Homo sapiens 20-24 17030394-2 2007 Organophosphate compounds produce excessive cholinergic overstimulation in the CNS via blocking acetylcholinesterase activity. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 17196318-4 2007 Accordingly, "Oxime-assisted Catalysis" by AChE provides a potential means for catalyzing the hydrolysis of organophosphates in plasma prior to their reaching the cellular target site. Organophosphates 108-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 17046138-1 2007 Selected mutagenesis of acetylcholinesterase (AChE; EC 3.1.1.7) may enable one to develop more effective scavenging agents in which AChE itself, in combination with an oxime, will complete a catalytic cycle of hydrolysis of the organophosphate by rapid conjugation followed by enhanced nucleophile-mediated hydrolysis of the phosphonyl enzyme conjugate. Organophosphates 228-243 acetylcholinesterase Mus musculus 46-50 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 279-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 279-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 17196318-6 2007 Finally, substituted AChE molecules can be conjugated to fluorophores giving rise to shifts in emission spectra for detection of dispersed organophosphates. Organophosphates 139-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 17046138-1 2007 Selected mutagenesis of acetylcholinesterase (AChE; EC 3.1.1.7) may enable one to develop more effective scavenging agents in which AChE itself, in combination with an oxime, will complete a catalytic cycle of hydrolysis of the organophosphate by rapid conjugation followed by enhanced nucleophile-mediated hydrolysis of the phosphonyl enzyme conjugate. Organophosphates 228-243 acetylcholinesterase Mus musculus 132-136 17223355-1 2007 A novel, proteomics based method was developed for the detection, quantification, and categorization of serum butyrylcholinesterase (BChE) inhibitors, including organophosphates (OPs) and carbamates (CBs). Organophosphates 179-182 butyrylcholinesterase Homo sapiens 110-131 17460182-1 2007 Paraoxonase1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme capable of hydrolyzing diverse substrates from organophosphate (OP) toxins to oxidized phospholipids. Organophosphates 121-136 paraoxonase 1 Homo sapiens 0-12 17460182-1 2007 Paraoxonase1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme capable of hydrolyzing diverse substrates from organophosphate (OP) toxins to oxidized phospholipids. Organophosphates 121-136 paraoxonase 1 Homo sapiens 14-18 17615108-1 2007 Organophosphates (OPs) that inhibit neuropathy target esterase (NTE) with subsequent ageing can produce OP-induced delayed neuropathy (OPIDN). Organophosphates 0-16 patatin like phospholipase domain containing 6 Homo sapiens 36-62 17615108-1 2007 Organophosphates (OPs) that inhibit neuropathy target esterase (NTE) with subsequent ageing can produce OP-induced delayed neuropathy (OPIDN). Organophosphates 0-16 patatin like phospholipase domain containing 6 Homo sapiens 64-67 17615108-1 2007 Organophosphates (OPs) that inhibit neuropathy target esterase (NTE) with subsequent ageing can produce OP-induced delayed neuropathy (OPIDN). Organophosphates 18-21 patatin like phospholipase domain containing 6 Homo sapiens 36-62 17615108-1 2007 Organophosphates (OPs) that inhibit neuropathy target esterase (NTE) with subsequent ageing can produce OP-induced delayed neuropathy (OPIDN). Organophosphates 18-21 patatin like phospholipase domain containing 6 Homo sapiens 64-67 17223355-0 2007 Development of a MALDI-TOF-MS method to identify and quantify butyrylcholinesterase inhibition resulting from exposure to organophosphate and carbamate pesticides. Organophosphates 122-137 butyrylcholinesterase Homo sapiens 62-83 17223355-1 2007 A novel, proteomics based method was developed for the detection, quantification, and categorization of serum butyrylcholinesterase (BChE) inhibitors, including organophosphates (OPs) and carbamates (CBs). Organophosphates 161-177 butyrylcholinesterase Homo sapiens 110-131 17590134-1 2007 Acute organophosphate poisoning leads to a cholinergic crisis secondary to an acetylcholine rise, developed by an acetylcholinesterase inhibition. Organophosphates 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 17381678-0 2007 Application of an electrometric method for measurement of blood cholinesterase activities in sheep, goats and cattle treated with organophosphate insecticides. Organophosphates 130-145 butyrylcholinesterase Bos taurus 64-78 17381678-1 2007 A modified electrometric cholinesterase method has been described for use in ruminants exposed to organophosphate insecticides. Organophosphates 98-113 butyrylcholinesterase Bos taurus 25-39 17381678-2 2007 The method was used to measure cholinesterase activities in the plasma and erythrocytes of sheep, goats and cattle treated with organophosphate insecticides under field conditions. Organophosphates 128-143 cholinesterase Ovis aries 31-45 17381678-7 2007 The results suggest that the described electrometric method could be efficiently used for detecting cholinesterase inhibition in ruminants exposed to organophosphate insecticides. Organophosphates 150-165 butyrylcholinesterase Bos taurus 100-114 17452951-2 2007 Organophosphates inhibit cholinesterase activity at the neuromuscular junction and cause extensive muscle paralysis, particularly for respiratory function. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 25-39 17141929-1 2007 Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide. Organophosphates 187-202 acetylcholinesterase Canis lupus familiaris 82-102 17141929-1 2007 Two studies were performed to find out whether exposure limits that protect brain acetylcholinesterase (AChE) will protect peripheral tissue AChE after exposure to chlorpyrifos (CPF), an organophosphate insecticide. Organophosphates 187-202 acetylcholinesterase Canis lupus familiaris 104-108 17454383-0 2007 Acetylcholinesterase-polyaniline biosensor investigation of organophosphate pesticides in selected organic solvents. Organophosphates 60-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17536765-1 2007 Birds of prey that are poisoned by cholinesterase inhibitors (e.g. organophosphate and carbamate insecticides) are often cared for at animal shelters, rehabilitation centres and wildlife diagnostic facilities. Organophosphates 67-82 butyrylcholinesterase Homo sapiens 35-49 17536768-0 2007 GST CYP and PON1 polymorphisms in farmers attributing ill health to organophosphate-containing sheep dip. Organophosphates 68-83 serum paraoxonase/arylesterase 1 Ovis aries 12-16 17536768-1 2007 Previously we reported that in sheep dippers exposed to organophosphates the frequency of paraoxonase (PON1) polymorphisms differed between those with or without self-reported ill health. Organophosphates 56-72 serum paraoxonase/arylesterase 1 Ovis aries 103-107 17366821-10 2007 CONCLUSIONS: Our results indicate that nonenzymatic functions of AChE variants may participate in and be predictive of the relative developmental neurotoxicity of organophosphates, and that the various organophosphates differ in the degree to which they activate this mechanism. Organophosphates 163-179 acetylcholinesterase Rattus norvegicus 65-69 18072155-1 2007 INTRODUCTION: The measurement of blood cholinesterase activity is a useful tool for monitoring exposure to organophosphate and carbamate insecticides. Organophosphates 107-122 butyrylcholinesterase Homo sapiens 39-53 18072155-17 2007 Using the modified electrometric method, various percentages of cholinesterase inhibitions in the plasma, erythrocytes, and whole blood were detected after in vitro addition of the organophosphate insecticides (chlorpyrifos and methidathion) and the carbamate insecticide (carbaryl) to the reaction mixtures. Organophosphates 181-196 butyrylcholinesterase Homo sapiens 64-78 17207828-3 2007 Given the biochemical and toxicological characteristics of these compounds, the hypothesis was made that the target of promotion is a phenyl valerate (PV) esterase similar to neuropathy target esterase (NTE), the target of organophosphate induced delayed polyneuropathy. Organophosphates 223-238 patatin like phospholipase domain containing 6 Homo sapiens 175-201 17207828-3 2007 Given the biochemical and toxicological characteristics of these compounds, the hypothesis was made that the target of promotion is a phenyl valerate (PV) esterase similar to neuropathy target esterase (NTE), the target of organophosphate induced delayed polyneuropathy. Organophosphates 223-238 patatin like phospholipase domain containing 6 Homo sapiens 203-206 17254622-1 2007 Cholinesterase inhibiting compounds such as carbamates and organophosphate insecticides have been widely used in agriculture since the ban on organochlorines in the 1970s. Organophosphates 59-74 cholinesterase Columba livia 0-14 17254622-2 2007 Carbofuran, a carbamate, and diazinon, an organophosphate, are among the most commonly implicated cholinesterase inhibitors in episodes of accidental avian toxicity and mortality. Organophosphates 42-57 cholinesterase Columba livia 98-112 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. Organophosphates 123-138 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 51-84 17253727-1 2007 Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. Organophosphates 123-138 flavin containing dimethylaniline monoxygenase 1 Homo sapiens 86-90 17454568-1 2007 Organophosphate (OP) and carbamate (CB) insecticides inhibit cholinesterase (ChE) activity and induce acute hypothermia in adult rats. Organophosphates 0-15 butyrylcholinesterase Rattus norvegicus 61-75 17454568-1 2007 Organophosphate (OP) and carbamate (CB) insecticides inhibit cholinesterase (ChE) activity and induce acute hypothermia in adult rats. Organophosphates 0-15 butyrylcholinesterase Rattus norvegicus 77-80 17141935-4 2007 Organophosphates block acetylcholinesterase activity, thereby inducing excessive cholinergic overstimulation in the central nervous system. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 17366821-0 2007 Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. Organophosphates 101-117 acetylcholinesterase Rattus norvegicus 26-46 17366821-1 2007 BACKGROUND: Organophosphate pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (AChE) enzymatic activity and resultant cholinergic hyperstimulation. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 17366821-1 2007 BACKGROUND: Organophosphate pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (AChE) enzymatic activity and resultant cholinergic hyperstimulation. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 17366821-10 2007 CONCLUSIONS: Our results indicate that nonenzymatic functions of AChE variants may participate in and be predictive of the relative developmental neurotoxicity of organophosphates, and that the various organophosphates differ in the degree to which they activate this mechanism. Organophosphates 202-218 acetylcholinesterase Rattus norvegicus 65-69 17098105-0 2006 Prognostic value of human erythrocyte acetyl cholinesterase in acute organophosphate poisoning. Organophosphates 69-84 butyrylcholinesterase Homo sapiens 45-59 18165198-1 2007 OBJECTIVES: The determination of cholinesterase activity has been commonly applied in the biomonitoring of exposure to organophosphates and carbamates and in the diagnosis of poisoning with anticholinesterase compounds. Organophosphates 119-135 butyrylcholinesterase Homo sapiens 33-47 16978909-1 2007 Neuropathy target esterase (NTE) was identified as the primary target of organophosphate compounds that cause a delayed neuropathy with degeneration of nerve axons. Organophosphates 73-88 patatin like phospholipase domain containing 6 Homo sapiens 0-26 16978909-1 2007 Neuropathy target esterase (NTE) was identified as the primary target of organophosphate compounds that cause a delayed neuropathy with degeneration of nerve axons. Organophosphates 73-88 patatin like phospholipase domain containing 6 Homo sapiens 28-31 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 17098105-1 2006 Acute organophosphate poisoning (OPP) such as dichlorvos may be monitored by the measurement of the erythrocyte acetyl cholinesterase (EAChE) and the serum cholinesterase (SChE) activities. Organophosphates 6-21 butyrylcholinesterase Homo sapiens 119-133 17098105-1 2006 Acute organophosphate poisoning (OPP) such as dichlorvos may be monitored by the measurement of the erythrocyte acetyl cholinesterase (EAChE) and the serum cholinesterase (SChE) activities. Organophosphates 6-21 butyrylcholinesterase Homo sapiens 156-170 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). Organophosphates 114-129 peptidylglycine alpha-amidating monooxygenase Homo sapiens 22-25 16563370-0 2006 The impact of aerial application of organophosphates on the cholinesterase levels of rural residents in the Vaalharts district, Northern Cape Province, South Africa. Organophosphates 36-52 butyrylcholinesterase Homo sapiens 60-74 16563370-1 2006 A cluster of Guillaine-Barre syndrome cases in the Vaalharts region, South Africa prompted an investigation of the impact of aerial organophosphate spraying on cholinesterase levels of residents in the region. Organophosphates 132-147 butyrylcholinesterase Homo sapiens 160-174 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16897762-1 2006 Carbamates are reversible inhibitors of acetylcholinesterase, and some also inhibit neuropathy target esterase (NTE), the target in organophosphate-induced delayed polyneuropathy. Organophosphates 132-147 patatin like phospholipase domain containing 6 Homo sapiens 84-110 16890390-0 2006 The use of serial measurement of plasma cholinesterase in the management of acute poisoning with organophosphates and carbamates. Organophosphates 97-113 butyrylcholinesterase Homo sapiens 40-54 17040217-1 2006 Weak and reversible inhibitors of cholinesterase, when co-administered in large doses, can act in a protective manner against more potent inhibitors such as organophosphates. Organophosphates 157-173 butyrylcholinesterase Rattus norvegicus 34-48 17035140-0 2006 Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Organophosphates 0-15 butyrylcholinesterase Rattus norvegicus 173-187 16897762-1 2006 Carbamates are reversible inhibitors of acetylcholinesterase, and some also inhibit neuropathy target esterase (NTE), the target in organophosphate-induced delayed polyneuropathy. Organophosphates 132-147 patatin like phospholipase domain containing 6 Homo sapiens 112-115 16807370-1 2006 Organophosphate pesticides (OPs), known inhibitors of acetylcholinesterase (AChE), are used extensively throughout the world. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 16970345-0 2006 Verification of exposure to organophosphates: Generic mass spectrometric method for detection of human butyrylcholinesterase adducts. Organophosphates 28-44 butyrylcholinesterase Homo sapiens 103-124 16970345-1 2006 We present a generic mass spectrometric method to verify exposure to organophosphates, based on the chemical conversion of the phosphylated peptides obtained after pepsin digestion of human butyrylcholinesterase (HuBuChE) to a common precursor peptide. Organophosphates 69-85 butyrylcholinesterase Homo sapiens 190-211 16801396-0 2006 Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 16801396-1 2006 Comparative protection studies in mice demonstrate that on a molar basis, recombinant human acetylcholinesterase (rHuAChE) confers higher levels of protection than native human butyrylcholinesterase (HuBChE) against organophosphate (OP) compound intoxication. Organophosphates 216-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 16331452-3 2006 PON1 hydrolyzes various organophosphates, including insecticides and nerve gases. Organophosphates 24-40 paraoxonase 1 Homo sapiens 0-4 16807370-1 2006 Organophosphate pesticides (OPs), known inhibitors of acetylcholinesterase (AChE), are used extensively throughout the world. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 16833148-0 2006 A comparison of the effects of single and repeated exposure to an organophosphate insecticide on acetylcholinesterase activity in mammals. Organophosphates 66-81 acetylcholinesterase Mus musculus 97-117 16863614-3 2006 It is also a potent cholinesterase inhibitor and an arylesterase, combating organophosphate poisoning and metabolization of environmental neurotoxins which might be responsible for neurodegeneration with aging. Organophosphates 76-91 butyrylcholinesterase Homo sapiens 20-34 16835048-2 2006 Plasma paraoxonase 1 (PON1) plays an important role in detoxification of various organophosphates. Organophosphates 81-97 paraoxonase 1 Homo sapiens 7-20 16835048-2 2006 Plasma paraoxonase 1 (PON1) plays an important role in detoxification of various organophosphates. Organophosphates 81-97 paraoxonase 1 Homo sapiens 22-26 16835048-11 2006 Most of the newborn children and some pregnant women in this Latino cohort may have elevated susceptibility to organophosphate toxicity because of their PON1192 genotype and low PON1 plasma levels. Organophosphates 111-126 paraoxonase 1 Homo sapiens 153-157 16835025-0 2006 Geographical distribution and evolutionary history of organophosphate-resistant Ace alleles in the olive fly (Bactrocera oleae). Organophosphates 54-69 acetylcholinesterase Bactrocera oleae 80-83 16872049-3 2006 Treatment of erythrocytes with organophosphates resulted in decreased erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, whereas activities of glutathione-s-transferase (GST) and glutathione reductase (GR) were increased. Organophosphates 31-47 glucose-6-phosphate dehydrogenase Rattus norvegicus 82-115 16872049-3 2006 Treatment of erythrocytes with organophosphates resulted in decreased erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, whereas activities of glutathione-s-transferase (GST) and glutathione reductase (GR) were increased. Organophosphates 31-47 glucose-6-phosphate dehydrogenase Rattus norvegicus 117-123 16872049-3 2006 Treatment of erythrocytes with organophosphates resulted in decreased erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, whereas activities of glutathione-s-transferase (GST) and glutathione reductase (GR) were increased. Organophosphates 31-47 glutathione-disulfide reductase Rattus norvegicus 193-214 16835025-1 2006 Acetylcholinesterase (Ace) is the molecular target of organophosphate (OP) insecticides, and two mutations that confer different levels of OP insensitivity have previously been identified in the olive fly, Bactrocera oleae. Organophosphates 54-69 acetylcholinesterase Bactrocera oleae 0-20 16872049-3 2006 Treatment of erythrocytes with organophosphates resulted in decreased erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity, whereas activities of glutathione-s-transferase (GST) and glutathione reductase (GR) were increased. Organophosphates 31-47 glutathione-disulfide reductase Rattus norvegicus 216-218 16835025-1 2006 Acetylcholinesterase (Ace) is the molecular target of organophosphate (OP) insecticides, and two mutations that confer different levels of OP insensitivity have previously been identified in the olive fly, Bactrocera oleae. Organophosphates 54-69 acetylcholinesterase Bactrocera oleae 0-3 16835025-5 2006 We hypothesize that the major force that shaped the current distribution of resistant and non-resistant acetylcholinesterase alleles is natural selection, likely responsible for the high frequency of insensitive alleles in areas where organophosphates have been used extensively. Organophosphates 235-251 acetylcholinesterase Bactrocera oleae 104-124 16850858-1 2006 Acute organophosphate poisoning (OP) shows several severe clinical symptoms due to its strong blocking effect on cholinesterase. Organophosphates 6-21 butyrylcholinesterase Homo sapiens 113-127 16464473-2 2006 Neuropathic organophosphates react covalently with the active site serine residue of NTE, causing degeneration of long axons in spinal cord and peripheral nerves which becomes clinically evident 1-3 weeks after exposure to OPs, hence termed as organophosphate induced delayed neuropathy. Organophosphates 12-28 patatin-like phospholipase domain containing 6 Rattus norvegicus 85-88 16464473-2 2006 Neuropathic organophosphates react covalently with the active site serine residue of NTE, causing degeneration of long axons in spinal cord and peripheral nerves which becomes clinically evident 1-3 weeks after exposure to OPs, hence termed as organophosphate induced delayed neuropathy. Organophosphates 12-27 patatin-like phospholipase domain containing 6 Rattus norvegicus 85-88 21432383-4 2006 Cholinesterase enzymes have been detected in animal ocular tissue, with evidence of organophosphate-induced inhibition. Organophosphates 84-99 butyrylcholinesterase Homo sapiens 0-14 16630337-6 2006 The risk of experiencing symptoms and the serum cholinesterase activity were influenced by whether or not organophosphates were used and the number of times sprayed. Organophosphates 106-122 butyrylcholinesterase Homo sapiens 48-62 16595195-1 2006 Human plasma paraoxonase (PON1) is calcium-dependent enzyme that hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties. Organophosphates 94-110 paraoxonase 1 Homo sapiens 26-30 16686937-1 2006 BACKGROUND: Acetylcholinesterase is irreversibly inhibited by organophosphate and carbamate insecticides allowing its use in biosensors for detection of these insecticides. Organophosphates 62-77 Acetylcholine esterase Drosophila melanogaster 12-32 16499876-7 2006 The observed early changes were concomitant with almost complete inhibition of the activity of neuropathy target esterase (NTE), one of the proposed early molecular targets in organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 176-191 patatin-like phospholipase domain containing 6 Mus musculus 95-121 16499876-7 2006 The observed early changes were concomitant with almost complete inhibition of the activity of neuropathy target esterase (NTE), one of the proposed early molecular targets in organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 176-191 patatin-like phospholipase domain containing 6 Mus musculus 123-126 16403852-2 2006 However, more recently certain kinetic complexities in the inhibition of acetylcholinesterase by organophosphates such as paraoxon (O,O-diethyl O-(p-nitrophenyl) phosphate) and chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) have raised questions regarding the adequacy of the kinetic scheme on which k(i) is based. Organophosphates 97-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 16309859-1 2006 Neuropathy target esterase (NTE) reacts with those organophosphates, which cause paralysis with swelling and degeneration of distal parts of long nerves in the legs and spinal cord. Organophosphates 51-67 patatin-like phospholipase domain containing 6 Mus musculus 0-26 16309859-1 2006 Neuropathy target esterase (NTE) reacts with those organophosphates, which cause paralysis with swelling and degeneration of distal parts of long nerves in the legs and spinal cord. Organophosphates 51-67 patatin-like phospholipase domain containing 6 Mus musculus 28-31 16309859-8 2006 In the nervous system of susceptible vertebrates, neuropathic organophosphates will cause a transient loss of NTE activity, putatively disrupting membrane phospholipid homeostasis and ER functions including axonal transport and glial-axonal interaction: the distal parts of long axons will be particularly vulnerable to loss of these support functions. Organophosphates 62-78 patatin-like phospholipase domain containing 6 Mus musculus 110-113 16733813-7 2006 Some of those genes (GFAP, NF-H, CaMKIIa, Calm, and MBP) have been shown by other laboratories and ours, to be involved in the pathogenesis of sarin-induced pathology and organophosphate-induced delayed neurotoxicity (OPIDN). Organophosphates 171-186 glial fibrillary acidic protein Rattus norvegicus 21-25 16423902-3 2006 Serum PON1 activity may also be important in avoidance of organophosphate toxicity in industry. Organophosphates 58-73 paraoxonase 1 Homo sapiens 6-10 16733813-7 2006 Some of those genes (GFAP, NF-H, CaMKIIa, Calm, and MBP) have been shown by other laboratories and ours, to be involved in the pathogenesis of sarin-induced pathology and organophosphate-induced delayed neurotoxicity (OPIDN). Organophosphates 171-186 neurofilament heavy chain Rattus norvegicus 27-31 16733813-7 2006 Some of those genes (GFAP, NF-H, CaMKIIa, Calm, and MBP) have been shown by other laboratories and ours, to be involved in the pathogenesis of sarin-induced pathology and organophosphate-induced delayed neurotoxicity (OPIDN). Organophosphates 171-186 calcium/calmodulin-dependent protein kinase II alpha Rattus norvegicus 33-40 16221533-0 2006 Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein. Organophosphates 10-25 ATP binding cassette subfamily B member 1 Homo sapiens 86-100 16495777-0 2006 PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity. Organophosphates 65-80 paraoxonase 1 Homo sapiens 0-4 16758984-1 2006 Current research activity in characteristic of biosensors associated with cholinesterase (ChE) for detection of organophosphate and carbamate pesticide residues is summarized. Organophosphates 112-127 butyrylcholinesterase Homo sapiens 74-88 16758984-1 2006 Current research activity in characteristic of biosensors associated with cholinesterase (ChE) for detection of organophosphate and carbamate pesticide residues is summarized. Organophosphates 112-127 butyrylcholinesterase Homo sapiens 90-93 16269825-1 2006 Paraoxonase-1 (PON1), an enzyme that metabolizes organophosphate insecticides, is secreted by the liver and transported in the blood complexed to HDL. Organophosphates 49-64 paraoxonase 1 Homo sapiens 0-13 16448058-1 2006 A highly sensitive flow injection amperometric biosensor for organophosphate pesticides and nerve agents based on self-assembled acetylcholinesterase (AChE) on a carbon nanotube (CNT)-modified glassy carbon (GC) electrode is described. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 16448058-7 2006 The developed PDDA/AChE/PDDA/CNT/GC biosensor integrated into a flow injection system was used to monitor organophosphate pesticides and nerve agents, such as paraoxon. Organophosphates 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 16269825-1 2006 Paraoxonase-1 (PON1), an enzyme that metabolizes organophosphate insecticides, is secreted by the liver and transported in the blood complexed to HDL. Organophosphates 49-64 paraoxonase 1 Homo sapiens 15-19 16517986-0 2006 The story of PON1: how an organophosphate-hydrolysing enzyme is becoming a player in cardiovascular medicine. Organophosphates 26-41 paraoxonase 1 Homo sapiens 13-17 16517986-2 2006 Initially, PON1 was identified as an enzyme capable of hydrolysing organophosphate compounds, but there is a growing body of evidence that PON1 plays a role in lipid metabolism and the onset of cardiovascular disease. Organophosphates 67-82 paraoxonase 1 Homo sapiens 11-15 16290160-1 2006 A method to identify and sequence recombinant mouse acetylcholinesterase (rMoAChE) including the native and organophosphate-modified active-site peptides was developed using capillary liquid chromatography with electrospray ionization, quadrupole/time-of-flight mass spectrometry. Organophosphates 108-123 acetylcholinesterase Mus musculus 52-72 16373816-4 2006 Emergency physicians should strongly consider cholinesterase inhibitor (rivastigmine, galantamine, and tacrine) ingestion in patients who present with short and temporary organophosphate-like toxidromes. Organophosphates 171-186 butyrylcholinesterase Homo sapiens 46-60 16289123-3 2005 In the brains of naive, un-stressed rats, the irreversible organophosphate antiChE, diisopropylfluorophosphonate (DFP) induced post-treatment accumulation of catalytically active G1 monomers of acetylcholinesterase (AChE). Organophosphates 59-74 acetylcholinesterase Rattus norvegicus 194-214 17192653-1 2006 The progressive inhibition of acetylcholinesterase (AChE [EC 3.1.1.7]) by organophosphates (OPs), such as the nerve agents tabun and soman, is due to phosphorylation of the active center serine characterized by the formation of conjugates and inactivation of this essential enzyme involved in neurotransmission. Organophosphates 74-90 acetylcholinesterase Mus musculus 30-50 17192653-1 2006 The progressive inhibition of acetylcholinesterase (AChE [EC 3.1.1.7]) by organophosphates (OPs), such as the nerve agents tabun and soman, is due to phosphorylation of the active center serine characterized by the formation of conjugates and inactivation of this essential enzyme involved in neurotransmission. Organophosphates 74-90 acetylcholinesterase Mus musculus 52-56 17192653-1 2006 The progressive inhibition of acetylcholinesterase (AChE [EC 3.1.1.7]) by organophosphates (OPs), such as the nerve agents tabun and soman, is due to phosphorylation of the active center serine characterized by the formation of conjugates and inactivation of this essential enzyme involved in neurotransmission. Organophosphates 92-95 acetylcholinesterase Mus musculus 30-50 17192653-1 2006 The progressive inhibition of acetylcholinesterase (AChE [EC 3.1.1.7]) by organophosphates (OPs), such as the nerve agents tabun and soman, is due to phosphorylation of the active center serine characterized by the formation of conjugates and inactivation of this essential enzyme involved in neurotransmission. Organophosphates 92-95 acetylcholinesterase Mus musculus 52-56 16256090-3 2005 Exposure to organophosphate (OP) chemical warfare agents (CWAs), pesticides, anesthetics, and a variety of drugs such as cocaine, as well as some neurodegenerative and liver disease states, selectively reduces AChE or BChE activity. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 16256090-3 2005 Exposure to organophosphate (OP) chemical warfare agents (CWAs), pesticides, anesthetics, and a variety of drugs such as cocaine, as well as some neurodegenerative and liver disease states, selectively reduces AChE or BChE activity. Organophosphates 12-27 butyrylcholinesterase Homo sapiens 218-222 18603880-1 2006 A case of organophosphate (OP) poisoning who recovered after requiring almost 1000 mg of atropine, 10 gm of PAM and ventilatory support for 7 days is presented here. Organophosphates 10-25 peptidylglycine alpha-amidating monooxygenase Homo sapiens 108-111 17125036-0 2006 [Possible consequences of acetylcholinesterase inhibition in organophosphate poisoning. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 16257396-1 2005 Organophosphate (OP) compounds exert inhibition on cholinesterase (ChE) activity by irreversibly binding to the catalytic site of the enzymes. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 51-65 16257396-1 2005 Organophosphate (OP) compounds exert inhibition on cholinesterase (ChE) activity by irreversibly binding to the catalytic site of the enzymes. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 67-70 16289123-3 2005 In the brains of naive, un-stressed rats, the irreversible organophosphate antiChE, diisopropylfluorophosphonate (DFP) induced post-treatment accumulation of catalytically active G1 monomers of acetylcholinesterase (AChE). Organophosphates 59-74 acetylcholinesterase Rattus norvegicus 216-220 16601802-2 2005 It differs from other highly toxic organophosphates by its chemical structure and by the fact that tabun-inhibited acetylcholinesterase is extraordinarily difficult to reactivate. Organophosphates 35-51 acetylcholinesterase Rattus norvegicus 115-135 16429504-1 2005 We investigated whether transcriptional inducers could enhance the expression of acetylcholinesterase (AChE) in cell lines to achieve protection against organophosphate (OP) poisoning. Organophosphates 153-168 acetylcholinesterase Mus musculus 103-107 16429574-1 2005 Several studies demonstrated that pretreatment with reversible acetylcholinesterase (AChE) inhibitor, such as (pyridostigmine) PYR, improved the survival of animals intoxicated by organophosphate nerve agents (OP). Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 16429574-1 2005 Several studies demonstrated that pretreatment with reversible acetylcholinesterase (AChE) inhibitor, such as (pyridostigmine) PYR, improved the survival of animals intoxicated by organophosphate nerve agents (OP). Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 16189388-0 2005 Pseudocholinesterase activity in organophosphate poisoning after storage of unseparated blood samples at room temperature for 3 weeks. Organophosphates 33-48 butyrylcholinesterase Homo sapiens 0-20 15922524-1 2005 Changes in erythrocyte delta-aminolevulinic acid dehydratase (ALA-D) have been reported after exposure to different pesticides, including organophosphates and paraquat. Organophosphates 138-154 aminolevulinate dehydratase Homo sapiens 23-60 15922524-1 2005 Changes in erythrocyte delta-aminolevulinic acid dehydratase (ALA-D) have been reported after exposure to different pesticides, including organophosphates and paraquat. Organophosphates 138-154 aminolevulinate dehydratase Homo sapiens 62-67 16149071-9 2005 These studies indicate that transcriptional inducers such as TSA up-regulate AChE, which then can bioscavenge any organophosphates present, thereby protecting the cells from OP-induced cytotoxicity. Organophosphates 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 16040183-1 2005 Toxicity of organophosphates (OP) is caused by inhibition of acetylcholinesterase (AChE), resulting in accumulation of acetylcholine. Organophosphates 12-28 acetylcholinesterase Mus musculus 61-81 16040183-1 2005 Toxicity of organophosphates (OP) is caused by inhibition of acetylcholinesterase (AChE), resulting in accumulation of acetylcholine. Organophosphates 12-28 acetylcholinesterase Mus musculus 83-87 16001972-0 2005 The readthrough variant of acetylcholinesterase remains very minor after heat shock, organophosphate inhibition and stress, in cell culture and in vivo. Organophosphates 85-100 acetylcholinesterase Mus musculus 27-47 16137924-1 2005 Certain organophosphates react with the active site serine residue of neuropathy target esterase (NTE) and cause axonal degeneration and paralysis. Organophosphates 8-24 patatin like phospholipase domain containing 6 Homo sapiens 98-101 16049284-9 2005 Upregulation of neuropathy target esterase and eukaryotic translation initiation factor 4G1 may suggest links with organophosphate exposure and virus infection, respectively. Organophosphates 115-130 patatin like phospholipase domain containing 6 Homo sapiens 16-42 16156589-7 2005 The frequency of GST-R in selected laboratory strains and field population correlated with the frequency of house flies surviving the organophosphate azamethiphos either topically applied or by ingestion. Organophosphates 134-149 glutathione S-transferase Musca domestica 17-20 16023296-0 2005 Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinesterase. Organophosphates 20-35 Heat-shock-protein-70Ab Drosophila melanogaster 96-101 16023296-0 2005 Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinesterase. Organophosphates 20-35 Heat-shock-protein-70Ab Drosophila melanogaster 122-127 16023296-0 2005 Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinesterase. Organophosphates 20-35 Acetylcholine esterase Drosophila melanogaster 168-188 16001972-4 2005 To generalize this observation, we attempted to quantify AChE(R) and AChE(T) after organophosphate intoxication in the mouse brain and compared the observed effects with those of stress induced by swimming or immobilization; we also analyzed the effects of heat shock and AChE inhibition on neuroblastoma cells. Organophosphates 83-98 acetylcholinesterase Mus musculus 57-61 16005131-0 2005 Effect of interleukin-10 on pancreatic damage caused by organophosphate poisoning. Organophosphates 56-71 interleukin 10 Rattus norvegicus 10-24 16005131-3 2005 We tested whether interleukin-10, a cytoprotective agent, could prevent or diminish pathological signs of acute pancreatitis caused by organophosphate poisoning. Organophosphates 135-150 interleukin 10 Rattus norvegicus 18-32 16005131-12 2005 Interleukin-10 should be considered for larger studies in other animal models to confirm its ability to decrease pancreatic damage after organophosphate poisoning treatment with interleukin-10. Organophosphates 137-152 interleukin 10 Rattus norvegicus 0-14 16005131-12 2005 Interleukin-10 should be considered for larger studies in other animal models to confirm its ability to decrease pancreatic damage after organophosphate poisoning treatment with interleukin-10. Organophosphates 137-152 interleukin 10 Rattus norvegicus 178-192 15888665-0 2005 Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Organophosphates 80-95 acylpeptide hydrolase Mus musculus 6-27 15772423-7 2005 Organophosphates are hydrolyzed almost exclusively by PON1, whereas bulky drug substrates such as lovastatin and spironolactone are hydrolyzed only by PON3. Organophosphates 0-16 paraoxonase 1 Homo sapiens 54-58 15863258-11 2005 The functional changes of nAChR at NMJ might play an important role in the paralysis of skeletal muscle following acute organophosphates (OPs) poisoning. Organophosphates 120-136 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 26-31 15863258-11 2005 The functional changes of nAChR at NMJ might play an important role in the paralysis of skeletal muscle following acute organophosphates (OPs) poisoning. Organophosphates 138-141 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 26-31 16335577-2 2005 Organophosphate insecticides inhibit cholinesterase (ChE) enzymatic activity, thereby eliciting cholinergic signs and symptoms. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 37-51 16335577-2 2005 Organophosphate insecticides inhibit cholinesterase (ChE) enzymatic activity, thereby eliciting cholinergic signs and symptoms. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 53-56 15982977-1 2005 BACKGROUND: Serum paraoxonase (PON1) provides protection against organophosphate induced toxicity. Organophosphates 65-80 serum paraoxonase/arylesterase 1 Ovis aries 31-35 21783509-7 2005 Paradoxically, the short-acting cholinesterase inhibitor pyridostigmine, an important therapeutic agent in the treatment of myasthenia gravis, was used during the Persian Gulf War to prevent the long-term clinical consequences of possible organophosphate nerve agent exposure. Organophosphates 239-254 butyrylcholinesterase Homo sapiens 32-46 16119193-2 2005 Owing to the fact that there exists no universal "broad-spectrum" reactivator of organophosphates-inhibited AChE, many laboratories have synthesized new AChE reactivators. Organophosphates 81-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 15823557-3 2005 In vitro, inhibition of NTE activity by organophosphates is correlated with inhibition of neurite initiation and reduction of neurite length, supporting the hypothesis that organophosphate-induced neurological disorders are caused by inhibition of NTE activity. Organophosphates 40-56 patatin-like phospholipase domain containing 6 Mus musculus 24-27 15823557-3 2005 In vitro, inhibition of NTE activity by organophosphates is correlated with inhibition of neurite initiation and reduction of neurite length, supporting the hypothesis that organophosphate-induced neurological disorders are caused by inhibition of NTE activity. Organophosphates 40-55 patatin-like phospholipase domain containing 6 Mus musculus 24-27 15951267-6 2005 In routine the measurement of acetylcholinesterase activity is more useful for the biological follow-up of subjects exposed to organophosphate phytosanitary compounds. Organophosphates 127-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21783514-1 2005 The organophosphate pesticides exhibit their action by inhibiting acetylcholinesterase (AChE) enzyme in central and peripheral nervous system. Organophosphates 4-19 acetylcholinesterase Rattus norvegicus 66-86 21783514-1 2005 The organophosphate pesticides exhibit their action by inhibiting acetylcholinesterase (AChE) enzyme in central and peripheral nervous system. Organophosphates 4-19 acetylcholinesterase Rattus norvegicus 88-92 21783515-1 2005 Biological monitoring of workers exposed to organophosphates consists mainly of measuring serum or erythrocyte cholinesterase activity. Organophosphates 44-60 butyrylcholinesterase Homo sapiens 111-125 15741058-0 2005 Sonochemically fabricated acetylcholinesterase micro-electrode arrays within a flow injection analyser for the determination of organophosphate pesticides. Organophosphates 128-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 16010971-9 2005 The result suggested that organophosphates may inhibit neural differentiation by initially acting on other targets other than NTE. Organophosphates 26-42 patatin like phospholipase domain containing 6 Homo sapiens 126-129 15767733-2 2005 They share the capacity to inhibit cholinesterase enzymes with organophosphates and therefore share similar symptomatology during acute and chronic exposures. Organophosphates 63-79 butyrylcholinesterase Homo sapiens 35-49 16105444-1 2005 OBJECTIVE: To study the relationship between the polymorphism of butyrylcholinesterase (BChE, EC 3.1.1.8) and paraoxonase (PonE, EC 3.1.8.1), and the individuals" genetic susceptibility to organophosphates pesticides (OPs) exposure. Organophosphates 189-205 butyrylcholinesterase Homo sapiens 65-86 16105444-1 2005 OBJECTIVE: To study the relationship between the polymorphism of butyrylcholinesterase (BChE, EC 3.1.1.8) and paraoxonase (PonE, EC 3.1.8.1), and the individuals" genetic susceptibility to organophosphates pesticides (OPs) exposure. Organophosphates 189-205 butyrylcholinesterase Homo sapiens 88-92 15707963-1 2005 Paraoxonase (Q isoenzyme, PON1) can effectively hydrolyze chlorpyrifos-oxon (CPO), soman, sarin, and other organophosphates. Organophosphates 107-123 paraoxonase 1 Mus musculus 26-30 15772346-3 2005 NTE reacts with organophosphate compounds that cause a paralyzing axonal degeneration in humans and has been shown to degrade endoplasmic reticulum-associated phosphatidylcholine (PtdCho) in cultured mammalian cells. Organophosphates 16-31 patatin like phospholipase domain containing 6 Homo sapiens 0-3 15762562-0 2005 Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15659565-0 2005 Neuroanatomical targets of the organophosphate chlorpyrifos by c-fos immunolabeling. Organophosphates 31-46 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 63-68 16036766-3 2005 The authors have previously shown that metoclopramide has a cholinesterase protective effect against inhibition by organophosphates (OPs). Organophosphates 115-131 butyrylcholinesterase Homo sapiens 60-74 16020401-1 2005 Organophosphate compounds act by irreversible inhibition of cholinesterase. Organophosphates 0-15 butyrylcholinesterase Rattus norvegicus 60-74 15767359-1 2005 Paraoxonase 1 (PON1) is an enzyme with multiple activities, including detoxification of organophosphates. Organophosphates 88-104 paraoxonase 1 Homo sapiens 0-13 15767359-1 2005 Paraoxonase 1 (PON1) is an enzyme with multiple activities, including detoxification of organophosphates. Organophosphates 88-104 paraoxonase 1 Homo sapiens 15-19 16036766-3 2005 The authors have previously shown that metoclopramide has a cholinesterase protective effect against inhibition by organophosphates (OPs). Organophosphates 133-136 butyrylcholinesterase Homo sapiens 60-74 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 paraoxonase 1 Homo sapiens 35-39 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 paraoxonase 1 Homo sapiens 196-200 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 paraoxonase 1 Homo sapiens 196-200 15734277-1 2005 Cholinesterase inhibitors, such as carbamates and organophosphates (OPs), are widely used as insecticides and pesticides and may be stored as biological weapons. Organophosphates 50-66 butyrylcholinesterase Homo sapiens 0-14 15734277-1 2005 Cholinesterase inhibitors, such as carbamates and organophosphates (OPs), are widely used as insecticides and pesticides and may be stored as biological weapons. Organophosphates 68-71 butyrylcholinesterase Homo sapiens 0-14 15727282-7 2005 Administration of exogenous plasma cholinesterase also has been shown to be effective in antagonizing mivacurium-induced neuromuscular block, cocaine toxicity, and organophosphate poisoning. Organophosphates 164-179 butyrylcholinesterase Homo sapiens 35-49 15670573-6 2005 As PON1 plays a protective role in organophosphate toxicity, and, because of its antioxidant capacity, in cardiovascular disease, a better understanding of how PON1 can be modulated by environmental factors has potential toxicological and clinical consequences. Organophosphates 35-50 paraoxonase 1 Homo sapiens 3-7 15673862-1 2005 Weak and reversible inhibitors of cholinesterase(s), when coadministered in excess with a more potent inhibitor such as organophosphates, can act in a protective manner. Organophosphates 120-136 butyrylcholinesterase Rattus norvegicus 34-48 15669039-1 2005 Weak and reversible inhibitors of cholinesterase, when coadministred in excess with a more potent inhibitor such as organophosphates, can act in a protective manner. Organophosphates 116-132 butyrylcholinesterase Rattus norvegicus 34-48 16537316-1 2005 INTRODUCTION: Measuring cholinesterase(ChE) enzyme levels in red blood cells (RBC) and plasma has become a useful tool in the early detection of organophosphate and carbamate poisoning in insecticide handlers. Organophosphates 145-160 butyrylcholinesterase Homo sapiens 24-38 15653099-0 2005 Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Organophosphates 87-102 paraoxonase 1 Homo sapiens 28-32 15669026-3 2005 We have shown that MCP has a cholinesterase protective effect against inhibition by organophosphates. Organophosphates 84-100 butyrylcholinesterase Homo sapiens 29-43 15548381-7 2004 The abilities of organochlorine (OC), organophosphate (OP) and pyrethroid pesticides (PY) to activate hPXR were also assessed and found to be consistent with the abilities of these compounds to induce CYP3A4 and CYP2B6 in primary culture of human hepatocytes. Organophosphates 38-53 nuclear receptor subfamily 1 group I member 2 Homo sapiens 102-106 16190146-4 2005 Butyrylcholinesterase and paraoxonase (PON1) enzyme variants associated with altered activity and acute organophosphate toxicity are strong candidate susceptibility factors for pesticides and NHL, but others may be identified as knowledge of pesticide metabolism and relevant polymorphisms improves. Organophosphates 104-119 paraoxonase 1 Homo sapiens 39-43 15498514-10 2004 HLo 7 was most potent with phosphonylated AChE and obidoxime with AChE inhibited by organophosphates and phosphoramidates. Organophosphates 84-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 15556357-0 2004 Acetylcholinesterase-based biosensor electrodes for organophosphate pesticide detection. Organophosphates 52-67 Acetylcholine esterase Drosophila melanogaster 0-20 15458977-1 2004 OBJECTIVE: The human paraoxonase-1 (PON-1) is a high-density lipoprotein-associated enzyme, mainly secreted by the liver, that displays protective properties toward cardiovascular disease and organophosphate intoxication. Organophosphates 192-207 paraoxonase 1 Homo sapiens 21-34 15556357-9 2004 The detection limit of the biosensors produced by non-covalent immobilization of acetylcholinesterase onto polyethyleneimine modified carbon electrodes was found to be about 10(-10) M for the organophosphate pesticide dichlorvos. Organophosphates 192-207 Acetylcholine esterase Drosophila melanogaster 81-101 15458977-1 2004 OBJECTIVE: The human paraoxonase-1 (PON-1) is a high-density lipoprotein-associated enzyme, mainly secreted by the liver, that displays protective properties toward cardiovascular disease and organophosphate intoxication. Organophosphates 192-207 paraoxonase 1 Homo sapiens 36-41 15522601-1 2004 An amperometric silica sol-gel film immobilized biosensor doped with acetylcholinesterase was fabricated in the laboratory finding application in organophosphate detection based on enzyme inhibition. Organophosphates 146-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 15342957-1 2004 Chronic and acute exposure to organophosphate (OP) pesticides may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 156-176 15342957-1 2004 Chronic and acute exposure to organophosphate (OP) pesticides may lead to persistent neurological and neurobehavioral effects, which cannot be explained by acetylcholinesterase (AChE) inhibition alone. Organophosphates 30-45 acetylcholinesterase Rattus norvegicus 178-182 15591769-3 2004 The brain stem locus coeruleus (LC) could be a mediator of organophosphate insecticide-induced behavioral toxicities since it contains high levels of acetylcholinesterase and is involved in the regulation of the sleep-wake cycle, attention, arousal, memory, and pathological processes, including anxiety and depression. Organophosphates 59-74 acetylcholinesterase Rattus norvegicus 150-170 15591771-7 2004 These results suggest that HSP70 induced in the RVLM during Mev intoxication provides neuroprotection against the organophosphate poison via prevention of cardiovascular depression. Organophosphates 114-129 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 27-32 16268118-4 2004 Results of this study show that erythrocyte AChE inhibition provides a good biomarker of exposure to organophosphate pesticides in field studies with human populations. Organophosphates 101-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 15476966-13 2004 Work is continuing to clone specific acetylcholinesterase (AChE) and carboxylesterase genes that appear to be involved in resistance to organophosphates. Organophosphates 136-152 acetylcholinesterase Bos taurus 59-63 15294802-2 2004 However, chlorpyrifos is hydrolyzed almost 1,000-fold slower than the preferred substrate, paraoxon, by organophosphorus hydrolase (OPH), an enzyme that can degrade a broad range of organophosphate pesticides. Organophosphates 182-197 acylaminoacyl-peptide hydrolase Homo sapiens 104-130 15294802-2 2004 However, chlorpyrifos is hydrolyzed almost 1,000-fold slower than the preferred substrate, paraoxon, by organophosphorus hydrolase (OPH), an enzyme that can degrade a broad range of organophosphate pesticides. Organophosphates 182-197 acylaminoacyl-peptide hydrolase Homo sapiens 132-135 15294802-7 2004 Considering that wild-type OPH hydrolyzes paraoxon at a rate close to the diffusion control limit, the 39-fold improvement in hydrolysis of paraoxon by B3561 suggests that this variant is one of the most efficient enzymes available to attack a wide spectrum of organophosphate nerve agents. Organophosphates 261-276 acylaminoacyl-peptide hydrolase Homo sapiens 27-30 15727399-9 2004 ACTH, cortisol, PRL, FT3, FT4, FSH, and PRG levels are affected by acute organophosphate poisoning. Organophosphates 73-88 proopiomelanocortin Homo sapiens 0-4 15727399-9 2004 ACTH, cortisol, PRL, FT3, FT4, FSH, and PRG levels are affected by acute organophosphate poisoning. Organophosphates 73-88 prolactin Homo sapiens 16-19 15294458-6 2004 We have here demonstrated that the thioether-containing organophosphate insecticides, phorate and disulfoton, are substrates for expressed human FMO2.1 with Km of 57 and 32 microM, respectively. Organophosphates 56-71 flavin containing dimethylaniline monoxygenase 2 Homo sapiens 145-149 15311856-0 2004 The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning. Organophosphates 79-94 butyrylcholinesterase Homo sapiens 39-53 15205026-1 2004 Previous reports in animals considered beta-glucuronidase activity as a novel biomarker of anticholinesterase (organophosphates and carbamates) pesticides exposure. Organophosphates 111-127 glucuronidase beta Homo sapiens 39-57 15207378-4 2004 The combination of differential metabolism of chiral organophosphorus (OP) pesticides and opposing stereoselectivity of inhibition of neuropathy target esterase (NTE) and acetylcholinesterase (AChE) can affect the value of the hen test, performed to OECD guidelines, in predicting the potential to cause organophosphate-induced delayed polyneuropathy (OPIDP) in humans. Organophosphates 304-319 patatin like phospholipase domain containing 6 Homo sapiens 134-160 15207378-4 2004 The combination of differential metabolism of chiral organophosphorus (OP) pesticides and opposing stereoselectivity of inhibition of neuropathy target esterase (NTE) and acetylcholinesterase (AChE) can affect the value of the hen test, performed to OECD guidelines, in predicting the potential to cause organophosphate-induced delayed polyneuropathy (OPIDP) in humans. Organophosphates 304-319 patatin like phospholipase domain containing 6 Homo sapiens 162-165 15207378-4 2004 The combination of differential metabolism of chiral organophosphorus (OP) pesticides and opposing stereoselectivity of inhibition of neuropathy target esterase (NTE) and acetylcholinesterase (AChE) can affect the value of the hen test, performed to OECD guidelines, in predicting the potential to cause organophosphate-induced delayed polyneuropathy (OPIDP) in humans. Organophosphates 304-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 15238287-9 2004 These associations with gestational age may be biologically plausible given that organophosphate pesticides depress cholinesterase and acetylcholine stimulates contraction of the uterus. Organophosphates 81-96 butyrylcholinesterase Homo sapiens 116-130 15311856-4 2004 PATIENT: A patient with organophosphate poisoning whose cholinesterase levels continuously decline and then increase up to a normal level after plasmapheresis is performed for his sepsis. Organophosphates 24-39 butyrylcholinesterase Homo sapiens 56-70 15004030-1 2004 Addition of an organophosphate source to UMR osteoblastic cultures activates a mineralization program in which BSP localizes to extracellular matrix sites where hydroxyapatite crystals are subsequently nucleated. Organophosphates 15-30 integrin binding sialoprotein Homo sapiens 111-114 15004030-5 2004 After organophosphate addition, BSP accumulates within these BAG-75-containing BMF precursors, with hydroxyapatite crystal nucleation occurring subsequently. Organophosphates 6-21 integrin binding sialoprotein Homo sapiens 32-35 15044461-2 2004 Here we present evidence that in both yeast and mammalian cells this deacylation is catalyzed by neuropathy target esterase (NTE), a protein originally identified by its reaction with organophosphates, which cause nerve axon degeneration. Organophosphates 184-200 patatin like phospholipase domain containing 6 Homo sapiens 97-123 15044461-2 2004 Here we present evidence that in both yeast and mammalian cells this deacylation is catalyzed by neuropathy target esterase (NTE), a protein originally identified by its reaction with organophosphates, which cause nerve axon degeneration. Organophosphates 184-200 patatin like phospholipase domain containing 6 Homo sapiens 125-128 15044461-6 2004 In [(14)C]choline labeling experiments with cultured mammalian cell lines, production of [(14)C]GroPCho was enhanced by overexpression of catalytically active NTE and was diminished by reduction of endogenous NTE activity mediated either by RNA interference or organophosphate treatment. Organophosphates 261-276 patatin like phospholipase domain containing 6 Homo sapiens 159-162 15044461-6 2004 In [(14)C]choline labeling experiments with cultured mammalian cell lines, production of [(14)C]GroPCho was enhanced by overexpression of catalytically active NTE and was diminished by reduction of endogenous NTE activity mediated either by RNA interference or organophosphate treatment. Organophosphates 261-276 patatin like phospholipase domain containing 6 Homo sapiens 209-212 15257517-3 2004 Organophosphates bind and inhibit cholinesterase enzymes. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 34-48 14985944-0 2004 Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase. Organophosphates 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 14985944-1 2004 The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme. Organophosphates 20-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 14985944-1 2004 The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme. Organophosphates 20-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 15081274-8 2004 This estimate in the rat, based on a limited data set of three organophosphates and a single carbamate, probably represents the minimum difference in the neurotoxicity of an untested cholinesterase-inhibiting pesticide that should be expected between the human neonate and adult. Organophosphates 63-79 butyrylcholinesterase Rattus norvegicus 183-197 15121994-4 2004 Children exposed to organophosphate insecticides and other pseudocholinesterase inhibitors may be at risk for cyclopentolate toxicity. Organophosphates 20-35 butyrylcholinesterase Homo sapiens 59-79 15051870-1 2004 Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by axonal degeneration. Organophosphates 121-138 patatin like phospholipase domain containing 6 Homo sapiens 0-26 15051870-1 2004 Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by axonal degeneration. Organophosphates 121-138 patatin like phospholipase domain containing 6 Homo sapiens 28-31 21782705-12 2004 In conclusion, immobilized butyrylcholinesterase (BChE) may be useful in scavenging and detoxifying organophosphate compounds both for medical protection and decontamination procedures. Organophosphates 100-115 butyrylcholinesterase Homo sapiens 27-48 20705007-5 2004 PON1, which is by far the most investigated member of this family, also catalyzes, albeit at much lower rates, the hydrolysis and thereby inactivation of various organophosphates (OPs), including the nerve agents sarin and soman. Organophosphates 162-178 paraoxonase 1 Mus musculus 0-4 20705007-5 2004 PON1, which is by far the most investigated member of this family, also catalyzes, albeit at much lower rates, the hydrolysis and thereby inactivation of various organophosphates (OPs), including the nerve agents sarin and soman. Organophosphates 180-183 paraoxonase 1 Mus musculus 0-4 21782705-12 2004 In conclusion, immobilized butyrylcholinesterase (BChE) may be useful in scavenging and detoxifying organophosphate compounds both for medical protection and decontamination procedures. Organophosphates 100-115 butyrylcholinesterase Homo sapiens 50-54 15018651-1 2004 BACKGROUND: Organophosphate and carbamate insecticides irreversibly inhibit acetylcholinesterase causing death of insects. Organophosphates 12-27 Acetylcholine esterase Drosophila melanogaster 76-96 14691213-1 2004 Chlorpyrifos, an acetylcholinesterase (AChE) inhibitor, is a widely used organophosphate pesticide. Organophosphates 73-88 acetylcholinesterase Rattus norvegicus 17-37 14691213-1 2004 Chlorpyrifos, an acetylcholinesterase (AChE) inhibitor, is a widely used organophosphate pesticide. Organophosphates 73-88 acetylcholinesterase Rattus norvegicus 39-43 15018650-4 2004 RESULTS: To obtain information on the origin of the fitness of resistant alleles, we studied Drosophila melanogaster acetylcholinesterase, the target of organophosphate and carbamate insecticides. Organophosphates 153-168 Acetylcholine esterase Drosophila melanogaster 117-137 15041023-1 2004 Two acetylcholinesterase genes, Ace1 and Ace2, have been fully cloned and sequenced from both organophosphate-resistant and susceptible clones of cotton aphid. Organophosphates 94-109 Acetylcholine esterase Drosophila melanogaster 4-24 15041023-1 2004 Two acetylcholinesterase genes, Ace1 and Ace2, have been fully cloned and sequenced from both organophosphate-resistant and susceptible clones of cotton aphid. Organophosphates 94-109 ACE1 Drosophila melanogaster 32-36 15041023-1 2004 Two acetylcholinesterase genes, Ace1 and Ace2, have been fully cloned and sequenced from both organophosphate-resistant and susceptible clones of cotton aphid. Organophosphates 94-109 Acetylcholine esterase Drosophila melanogaster 41-45 15052610-3 2004 Metoclopramide may have a cholinesterase protective effect against inhibition by organophosphates. Organophosphates 81-97 butyrylcholinesterase Homo sapiens 26-40 15052610-11 2004 The protective effect of MCP on cholinesterase could be of practical relevance in the treatment of organophosphate poisoning. Organophosphates 99-114 butyrylcholinesterase Homo sapiens 32-46 14992203-1 2004 The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be administered to humans to protect them from the lethal effects of organophosphate nerve agents. Organophosphates 160-176 butyrylcholinesterase Homo sapiens 101-122 14503920-3 2004 108, 736-739] in patients with chronic fatigue syndrome (CFS) are also present in those with Gulf War syndrome (GWS) and agricultural workers exposed to organophosphate pesticides, where cholinesterase inhibition is specifically implicated. Organophosphates 153-168 butyrylcholinesterase Homo sapiens 187-201 14749382-2 2004 Neuropathy target esterase (NTE), the vertebrate homologue of SWS, reacts with organophosphates which initiate a syndrome of axonal degeneration. Organophosphates 79-95 patatin-like phospholipase domain containing 6 Mus musculus 0-26 14749382-2 2004 Neuropathy target esterase (NTE), the vertebrate homologue of SWS, reacts with organophosphates which initiate a syndrome of axonal degeneration. Organophosphates 79-95 patatin-like phospholipase domain containing 6 Mus musculus 28-31 14992203-1 2004 The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be administered to humans to protect them from the lethal effects of organophosphate nerve agents. Organophosphates 160-176 butyrylcholinesterase Homo sapiens 309-330 14992203-1 2004 The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be administered to humans to protect them from the lethal effects of organophosphate nerve agents. Organophosphates 412-427 butyrylcholinesterase Homo sapiens 101-122 14992203-1 2004 The highlighted article in this issue (Ashani and Pistinner, "Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates toxicity: A Mathematically Based Toxicokinetic Model") is an innovative approach to modeling the amount of protective enzyme, human butyrylcholinesterase, that could be administered to humans to protect them from the lethal effects of organophosphate nerve agents. Organophosphates 412-427 butyrylcholinesterase Homo sapiens 309-330 15461241-1 2004 BACKGROUND: Approximately 35% of patients acutely poisoned with organophosphates (OP) in developing countries like Sri Lanka require intensive care and mechanical ventilation. Organophosphates 64-80 sorcin Homo sapiens 115-118 15508279-1 2004 Enzyme electrodes for the determination of organophosphate pesticides were developed by using acetylcholinesterase (AChE) in combination with a pH electrode. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 15508279-1 2004 Enzyme electrodes for the determination of organophosphate pesticides were developed by using acetylcholinesterase (AChE) in combination with a pH electrode. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 15462154-0 2004 The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning. Organophosphates 90-105 butyrylcholinesterase Homo sapiens 38-52 14635269-2 2003 In addition, MCP is a reversible inhibitor of cholinesterases from the human central nervous system and blood, and may have a red blood cell (RBC) acetylcholinesterase (AChE) protective effect against inhibition by organophosphates. Organophosphates 215-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 14686479-4 2003 PON1 activity towards paraoxon was nonsignificantly decreased (up to 53.5%) in the sprayers subgroup exposed to organophosphates (n = 41) compared with nonsprayers acting as controls (n = 39). Organophosphates 112-128 paraoxonase 1 Homo sapiens 0-4 14686479-6 2003 Among the environmental factors that significantly predicted lower rates of PON1 activity towards paraoxon are, interestingly, the exposure to organophosphates and current smoking. Organophosphates 143-159 paraoxonase 1 Homo sapiens 76-80 14686479-8 2003 This study suggests that chronic exposure to pesticides might decrease PON1 activity and pinpoints the potential usefulness of monitoring PON1 activity in occupational settings where exposure to organophosphates occurs. Organophosphates 195-211 paraoxonase 1 Homo sapiens 138-142 15639788-0 2004 Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes. Organophosphates 16-31 acetylcholinesterase Rattus norvegicus 42-62 14551701-3 2003 However, emerging evidence from biochemical and genetic experiments is providing clues about the role(s) of the products of these genes, which indicates that PON(s) acts as important guardians against cellular damage from toxic agents, such as organophosphates, oxidized lipids in the plasma low-density lipoproteins. Organophosphates 244-260 paraoxonase 1 Homo sapiens 158-161 14626722-0 2003 The clinical and electrophysiological features of a delayed polyneuropathy developing subsequently after acute organophosphate poisoning and it"s correlation with the serum acetylcholinesterase. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 12851386-2 2003 AChE is inactivated by organophosphates as they pass through the P-site and phosphorylate the catalytic serine in the A-site. Organophosphates 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12893843-2 2003 Extensive in vitro tests of these oximes with acetylcholinesterase inhibited by two different organophosphate agents, echothiophate and diisopropylfluorophosphate, revealed one compound with particularly good reactivation kinetics and affinity for phosphorylated acetylcholinesterase (AChE). Organophosphates 94-109 acetylcholinesterase Rattus norvegicus 46-66 14511322-2 2003 Inactivation of acetylcholinesterase (AChE) by organophosphates produces respiratory failure but AChE knockout mice survive to adulthood. Organophosphates 47-63 acetylcholinesterase Mus musculus 16-36 12974645-1 2003 A sensitive matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry procedure has been established for the detection and quantitation of acetylcholinesterase (AChE) inhibition by organophosphate (OP) compounds. Organophosphates 212-227 acetylcholinesterase Mus musculus 170-190 12974645-1 2003 A sensitive matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry procedure has been established for the detection and quantitation of acetylcholinesterase (AChE) inhibition by organophosphate (OP) compounds. Organophosphates 212-227 acetylcholinesterase Mus musculus 192-196 14677367-1 2003 This paper describes bioanalytical methods and biosensors which rely on cholinesterase (ChE) inhibition and can be used to detect and test the toxicity of organophosphate (OP) and carbamate pesticides. Organophosphates 155-170 butyrylcholinesterase Rattus norvegicus 72-86 14677367-1 2003 This paper describes bioanalytical methods and biosensors which rely on cholinesterase (ChE) inhibition and can be used to detect and test the toxicity of organophosphate (OP) and carbamate pesticides. Organophosphates 155-170 butyrylcholinesterase Rattus norvegicus 88-91 14511322-2 2003 Inactivation of acetylcholinesterase (AChE) by organophosphates produces respiratory failure but AChE knockout mice survive to adulthood. Organophosphates 47-63 acetylcholinesterase Mus musculus 38-42 12879443-2 2003 This syndrome of nerve axon degeneration is initiated by organophosphates which react with neuropathy target esterase (NTE). Organophosphates 57-73 patatin-like phospholipase domain containing 6 Mus musculus 91-117 12879443-2 2003 This syndrome of nerve axon degeneration is initiated by organophosphates which react with neuropathy target esterase (NTE). Organophosphates 57-73 patatin-like phospholipase domain containing 6 Mus musculus 119-122 14653904-7 2003 Organophosphates inhibit the activity of both the cholinesterase (ChE) enzymes-red blood cell (RBC) ChE and serum ChE-resulting in the cholinergic features of organophosphate toxicity. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 50-64 14653904-7 2003 Organophosphates inhibit the activity of both the cholinesterase (ChE) enzymes-red blood cell (RBC) ChE and serum ChE-resulting in the cholinergic features of organophosphate toxicity. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 66-69 14653904-7 2003 Organophosphates inhibit the activity of both the cholinesterase (ChE) enzymes-red blood cell (RBC) ChE and serum ChE-resulting in the cholinergic features of organophosphate toxicity. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 100-103 14653904-7 2003 Organophosphates inhibit the activity of both the cholinesterase (ChE) enzymes-red blood cell (RBC) ChE and serum ChE-resulting in the cholinergic features of organophosphate toxicity. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 100-103 14653904-7 2003 Organophosphates inhibit the activity of both the cholinesterase (ChE) enzymes-red blood cell (RBC) ChE and serum ChE-resulting in the cholinergic features of organophosphate toxicity. Organophosphates 159-174 butyrylcholinesterase Homo sapiens 50-64 14653904-7 2003 Organophosphates inhibit the activity of both the cholinesterase (ChE) enzymes-red blood cell (RBC) ChE and serum ChE-resulting in the cholinergic features of organophosphate toxicity. Organophosphates 159-174 butyrylcholinesterase Homo sapiens 66-69 14653904-8 2003 A 50% reduction in serum ChE activity from the baseline is an indication of acute organophosphate toxicity. Organophosphates 82-97 butyrylcholinesterase Homo sapiens 25-28 14653904-9 2003 The RBC ChE activity, which is less rapidly depressed than the serum ChE activity, is a measure of chronic exposure to organophosphates. Organophosphates 119-135 butyrylcholinesterase Homo sapiens 8-11 14653904-9 2003 The RBC ChE activity, which is less rapidly depressed than the serum ChE activity, is a measure of chronic exposure to organophosphates. Organophosphates 119-135 butyrylcholinesterase Homo sapiens 69-72 14527200-1 2003 The physiological role of human paraoxonase (PON), a serum enzyme that hydrolyzes organophosphate insecticides and nerve agents, is not clear. Organophosphates 82-97 paraoxonase 1 Homo sapiens 32-43 12907237-0 2003 Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase. Organophosphates 70-85 acetylcholinesterase Mus musculus 96-116 12907237-7 2003 Results indicate that the HI-6 molecule may assume two different orientations in the reactivation of AChE inhibited by organophosphate and Sp methylphosphonates. Organophosphates 119-134 acetylcholinesterase Mus musculus 101-105 14979094-1 2003 The role of the polymorphic cytochrome P450 (CYP) 2D6 isoform in catalysing the oxidative biotransformation of the organophosphate pesticide chlorpyriphos and the carbamate aldicarb into structures that inhibit cholinesterase and induce genotoxicity has been investigated in microsomal fraction, using quinine as a specific chemical inhibitor of CYP 2D6. Organophosphates 115-130 butyrylcholinesterase Rattus norvegicus 211-225 12837382-1 2003 To improve the potency of 2-pralidoxime (2-PAM) for treating organophosphate poisoning, we dimerized 2-PAM and its analogs according to Wilson"s pioneering work and the 3D structure of human acetylcholinesterase (hAChE) inactivated by isoflurophate. Organophosphates 61-76 peptidylglycine alpha-amidating monooxygenase Homo sapiens 43-46 14748471-11 2003 INTERPRETATION & CONCLUSION: In acute organophosphate poisoning, severe and prolonged acetylcholinesterase inhibition is associated with oxidative stress, detected in erythrocyte membranes, that occurs early in the course of poisoning and may contribute to the development and severity of intermediate syndrome. Organophosphates 42-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 12928148-1 2003 PON1 (paraoxonase-1) detoxifies organophosphates by cleavage of active oxons before they have a chance to inhibit cholinesterases. Organophosphates 32-48 paraoxonase 1 Homo sapiens 0-4 12928148-1 2003 PON1 (paraoxonase-1) detoxifies organophosphates by cleavage of active oxons before they have a chance to inhibit cholinesterases. Organophosphates 32-48 paraoxonase 1 Homo sapiens 6-19 12928148-8 2003 Compared with adults, neonates had lower PON1 activity, implying reduced capacity to detoxify organophosphates. Organophosphates 94-110 paraoxonase 1 Homo sapiens 41-45 12855907-1 2003 Serum paraoxonase (PON1) is responsible for the metabolism of organophosphates in serum, and PON1 activity is a major determinant of their toxicity in humans. Organophosphates 62-78 paraoxonase 1 Homo sapiens 19-23 12818696-2 2003 One possible therapeutic approach would be to employ adenosine A(1) receptor agonists, which have already been shown to have protective effects against organophosphate poisoning. Organophosphates 152-167 adenosine receptor A1 Cavia porcellus 53-76 12818696-3 2003 Using an in vitro model of organophosphate-induced seizures, we have investigated the ability of several adenosine A(1) receptor agonists to inhibit epileptiform activity induced by the organophosphate sarin, in the CA1 stratum pyramidale of the guinea pig hippocampal slice. Organophosphates 186-201 adenosine receptor A1 Cavia porcellus 105-128 12818696-6 2003 These data suggest that partial adenosine A(1) receptor agonists, which have fewer cardiovascular effects, should be further evaluated in vivo as potential treatments for organophosphate poisoning. Organophosphates 171-186 adenosine receptor A1 Cavia porcellus 32-55 14527200-1 2003 The physiological role of human paraoxonase (PON), a serum enzyme that hydrolyzes organophosphate insecticides and nerve agents, is not clear. Organophosphates 82-97 paraoxonase 1 Homo sapiens 45-48 12505439-1 2003 Toxicity of organophosphates stems mainly from the accumulation of acetylcholine due to inhibition of acetylcholinesterase (AChE). Organophosphates 12-28 acetylcholinesterase Rattus norvegicus 102-122 12679808-2 2003 Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun. Organophosphates 144-159 carboxylesterase 1 Homo sapiens 6-24 12679808-2 2003 Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun. Organophosphates 144-159 carboxylesterase 1 Homo sapiens 26-30 12724622-1 2003 Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL. Organophosphates 110-125 paraoxonase 1 Homo sapiens 13-17 12676613-0 2003 Interaction of organophosphate pesticides and related compounds with the androgen receptor. Organophosphates 15-30 androgen receptor Homo sapiens 73-90 12676613-2 2003 We previously demonstrated AR antagonist activity of the organophosphate (OP) pesticide fenitrothion. Organophosphates 57-72 androgen receptor Homo sapiens 27-29 12640454-0 2003 Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. Organophosphates 49-64 patatin-like phospholipase domain containing 6 Mus musculus 8-34 12505439-1 2003 Toxicity of organophosphates stems mainly from the accumulation of acetylcholine due to inhibition of acetylcholinesterase (AChE). Organophosphates 12-28 acetylcholinesterase Rattus norvegicus 124-128 12566597-3 2003 PON-1 is also an arylesterase that hydrolyzes paraoxon, an active toxic metabolite of parathion, thus providing protection against organophosphate poisoning and metabolization of environmental neurotoxins that might be responsible for neurodegeneration with aging. Organophosphates 131-146 paraoxonase 1 Homo sapiens 0-5 12618125-9 2003 This mechanism may explain central side effects previously attributed to this drug as well as the potency of AChE inhibitors, including nerve-gas agents and organophosphate pesticides, in the initiation of cortical synchronization, epileptic discharge, and excitotoxic damage. Organophosphates 157-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 12563177-1 2003 OBJECTIVES: Human serum paraoxonase (PON1) hydrolyses organophosphate pesticides (OPs) entering the blood circulation and tissue fluid thus limiting toxicity. Organophosphates 54-69 serum paraoxonase/arylesterase 1 Ovis aries 37-41 12563177-11 2003 CONCLUSIONS: The farmers reporting chronic ill health due to organophosphate exposure have a higher proportion of the PON1-192R polymorphism associated with lower rates of diazoxon hydrolysis and lower rates of diazoxon hydrolysis than the controls and that their ill health may be explained by a lower ability to detoxify diazoxon. Organophosphates 61-76 serum paraoxonase/arylesterase 1 Ovis aries 118-122 12519632-0 2003 Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Organophosphates 57-72 paraoxonase 1 Mus musculus 13-18 12693837-1 2003 Deliberate self-harm by ingestion of organophosphate insecticides is a common health problem in Sri Lanka. Organophosphates 37-52 sorcin Homo sapiens 96-99 12583695-1 2003 Early treatment of organophosphate (OP) poisoning with oximes results in reactivation of acetylcholinesterase and patient recovery. Organophosphates 19-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 12480756-1 2002 An esterase, paraoxonase 1 (PON1), protects against organophosphate neurotoxicity and decreases lipoprotein oxidation. Organophosphates 52-67 paraoxonase 1 Homo sapiens 13-26 12645966-0 2003 Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. Organophosphates 85-101 paraoxonase 1 Homo sapiens 17-28 12645966-0 2003 Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. Organophosphates 85-101 paraoxonase 1 Homo sapiens 30-34 12478623-8 2003 Generally, the brain stem was highly sensitive to organophosphate-induced inhibition of AChE activity and [(3)H]QNB binding. Organophosphates 50-65 acetylcholinesterase Rattus norvegicus 88-92 12638169-5 2003 Although neurotoxic esterase (NTE) inhibition might be related to the onset of organophosphate-induced delayed neurotoxicity (OPIDN), the precise mode of action is not yet clear. Organophosphates 79-94 patatin like phospholipase domain containing 6 Homo sapiens 9-28 12638169-5 2003 Although neurotoxic esterase (NTE) inhibition might be related to the onset of organophosphate-induced delayed neurotoxicity (OPIDN), the precise mode of action is not yet clear. Organophosphates 79-94 patatin like phospholipase domain containing 6 Homo sapiens 30-33 12480756-1 2002 An esterase, paraoxonase 1 (PON1), protects against organophosphate neurotoxicity and decreases lipoprotein oxidation. Organophosphates 52-67 paraoxonase 1 Homo sapiens 28-32 12396499-1 2002 Acetylcholinesterase (AChE) is the target of two major insecticide families, organophosphates (OPs) and carbamates. Organophosphates 77-93 Acetylcholine esterase Drosophila melanogaster 0-20 12396499-1 2002 Acetylcholinesterase (AChE) is the target of two major insecticide families, organophosphates (OPs) and carbamates. Organophosphates 77-93 Acetylcholine esterase Drosophila melanogaster 22-26 12396499-1 2002 Acetylcholinesterase (AChE) is the target of two major insecticide families, organophosphates (OPs) and carbamates. Organophosphates 95-98 Acetylcholine esterase Drosophila melanogaster 0-20 12396499-1 2002 Acetylcholinesterase (AChE) is the target of two major insecticide families, organophosphates (OPs) and carbamates. Organophosphates 95-98 Acetylcholine esterase Drosophila melanogaster 22-26 12190811-1 2002 Organophosphates (OP) are irreversibly bound to cholinesterase, causing deactivation of acetylcholinesterase. Organophosphates 0-16 butyrylcholinesterase Homo sapiens 48-108 12242675-1 2002 The activities of cholinesterase (ChE) and glutathione S-transferase (GST) enzymes were assessed in the wolf spider (Lycosa hilaris) as biomarkers of organophosphate contamination in agricultural ecosystems. Organophosphates 150-165 glutathione S-transferase kappa 1 Homo sapiens 70-73 12242675-9 2002 Inhibition of ChE activity after a single application of Basudin indicate the potential use of this enzyme in wolf spiders as a biomarker for evaluating organophosphate contamination. Organophosphates 153-168 butyrylcholinesterase Homo sapiens 14-17 12149129-1 2002 BACKGROUND: Acetylcholinesterase is irreversibly inhibited by organophosphate and carbamate insecticides allowing its use for residue detection with biosensors. Organophosphates 62-77 Acetylcholine esterase Drosophila melanogaster 12-32 12144698-1 2002 A 2.2-kb full length cDNA containing an ORF encoding a putative acetylcholinesterase (AChE) precursor of 673 amino acid residues was obtained by a combined degenerate PCR and RACE strategy from an organophosphate-susceptible Bactrocera oleae strain. Organophosphates 197-212 acetylcholinesterase Bactrocera oleae 64-84 12144698-1 2002 A 2.2-kb full length cDNA containing an ORF encoding a putative acetylcholinesterase (AChE) precursor of 673 amino acid residues was obtained by a combined degenerate PCR and RACE strategy from an organophosphate-susceptible Bactrocera oleae strain. Organophosphates 197-212 acetylcholinesterase Bactrocera oleae 86-90 12242610-0 2002 Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Organophosphates 95-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 12242610-1 2002 Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Organophosphates 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 12210872-1 2002 Paraoxonase1 (PON1) is an arylesterase mainly expressed in the liver that hydrolyzes organophosphates such as pesticides, reported risk factors for Parkinson"s disease (PD), and other neurotoxins. Organophosphates 85-101 paraoxonase 1 Homo sapiens 0-12 12201064-2 2002 The results showed that positive Fn staining could only be observed in groups of myocardial infarction and myocarditis, but could not be found in groups of mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion, and organophosphate poisoning. Organophosphates 234-249 fibronectin 1 Homo sapiens 33-35 12210872-1 2002 Paraoxonase1 (PON1) is an arylesterase mainly expressed in the liver that hydrolyzes organophosphates such as pesticides, reported risk factors for Parkinson"s disease (PD), and other neurotoxins. Organophosphates 85-101 paraoxonase 1 Homo sapiens 14-18 12046961-8 2002 The considerable variability of the brain cholinesterase activities in avian and mammalian species illustrates the need for reliable normal values for individual species to improve ability to monitor environmental exposure or to confirm acute poisonings associated with organophosphate or carbamate insecticides. Organophosphates 270-285 butyrylcholinesterase Homo sapiens 42-56 11927584-1 2002 A neuronal membrane protein, neuropathy target esterase (NTE), reacts with those organophosphates that initiate a syndrome of axonal degeneration. Organophosphates 81-97 patatin like phospholipase domain containing 6 Homo sapiens 29-55 11927584-1 2002 A neuronal membrane protein, neuropathy target esterase (NTE), reacts with those organophosphates that initiate a syndrome of axonal degeneration. Organophosphates 81-97 patatin like phospholipase domain containing 6 Homo sapiens 57-60 12024798-8 2002 Other experiments determined multiple dose levels in chickens for sarin and DFP that inhibited > 80% of NTE, considered a threshold for triggering organophosphate-induced delayed neuropathy. Organophosphates 150-165 patatin like phospholipase domain containing 6 Gallus gallus 107-110 12074828-1 2002 OBJECTIVES: The common K variant of butyrylcholinesterase (BChE-K), an enzyme which metabolizes acetylcholine and organophosphates, has been associated with Alzheimer"s disease, especially in the presence of the apolipoprotein E epsilon 4 allele (APOE-epsilon 4). Organophosphates 114-130 apolipoprotein E Homo sapiens 212-238 12074828-3 2002 Paraoxonase 1 (PON1), located within HDL, is an enzyme which also metabolizes organophosphates and may be antiatherogenic. Organophosphates 78-94 paraoxonase 1 Homo sapiens 0-13 12074828-3 2002 Paraoxonase 1 (PON1), located within HDL, is an enzyme which also metabolizes organophosphates and may be antiatherogenic. Organophosphates 78-94 paraoxonase 1 Homo sapiens 15-19 12059071-1 2002 Human paraoxonase (PON1) is a calcium-dependent esterase exclusively bound to apolipoprotein A-I and clusterin, containing high-density lipoprotein (HDL) particles that hydrolyzes organophosphates and aryl esters. Organophosphates 180-196 paraoxonase 1 Homo sapiens 19-23 12141395-1 2002 Recently, interindividual variations in serum paraoxonase (PON1) activity and the differences in its metabolic activity towards different organophosphates (OPs) caused by the coding region polymorphisms L55M and Q192R have been found to be important risk factors in susceptibility to OP poisoning. Organophosphates 138-154 paraoxonase 1 Homo sapiens 59-63 12059071-1 2002 Human paraoxonase (PON1) is a calcium-dependent esterase exclusively bound to apolipoprotein A-I and clusterin, containing high-density lipoprotein (HDL) particles that hydrolyzes organophosphates and aryl esters. Organophosphates 180-196 apolipoprotein A1 Homo sapiens 78-96 11888590-1 2002 Human serum paraoxonase (PON1) hydrolyses diazinonoxon, the active metabolite of diazinon, which is an organophosphate used in sheep dip. Organophosphates 103-118 serum paraoxonase/arylesterase 1 Ovis aries 25-29 11886776-6 2002 The kinetic characteristics of acetylcholinesterase, the target enzyme of organophosphates and carbamates, revealed that acetylcholinesterase in RLAB was less sensitive to inhibition by paraoxon and methomyl in comparison with SAMB. Organophosphates 74-90 acetylcholinesterase-like Tetranychus urticae 31-51 11886776-6 2002 The kinetic characteristics of acetylcholinesterase, the target enzyme of organophosphates and carbamates, revealed that acetylcholinesterase in RLAB was less sensitive to inhibition by paraoxon and methomyl in comparison with SAMB. Organophosphates 74-90 acetylcholinesterase-like Tetranychus urticae 121-141 11815411-5 2002 Paraoxonase 1 is a critical enzyme for inactivating neurotoxic intermediates in the metabolism of organophosphates. Organophosphates 98-114 paraoxonase 1 Homo sapiens 0-13 12201035-1 2002 A number of reports indicate that exposure to organophosphates (OPs), inhibitors of acetylcholinesterase (AChE), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. Organophosphates 46-62 acetylcholinesterase Rattus norvegicus 84-104 12201035-1 2002 A number of reports indicate that exposure to organophosphates (OPs), inhibitors of acetylcholinesterase (AChE), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. Organophosphates 46-62 acetylcholinesterase Rattus norvegicus 106-110 12201035-1 2002 A number of reports indicate that exposure to organophosphates (OPs), inhibitors of acetylcholinesterase (AChE), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. Organophosphates 64-67 acetylcholinesterase Rattus norvegicus 84-104 12201035-1 2002 A number of reports indicate that exposure to organophosphates (OPs), inhibitors of acetylcholinesterase (AChE), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. Organophosphates 64-67 acetylcholinesterase Rattus norvegicus 106-110 11846640-4 2002 Most nonoccupational illnesses resulting from entry into areas treated with chlorpyrifos likely stem from odor, rather than the ability of the organophosphate to inhibit AChE. Organophosphates 143-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 11852665-10 2002 All, including Tabun, Sarin, Soman, and VX, are organophosphates that inactivate acetylcholinesterase. Organophosphates 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 12507060-0 2002 Serum acetylcholinesterase and prognosis of acute organophosphate poisoning. Organophosphates 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 12507060-1 2002 OBJECTIVE: The aim of this study is to investigate the prognostic value of serum acetylcholinesterase levels and their relationship with neurological syndromes (Type 1 syndrome, intermediate syndrome, and delayed polyneuropathy) in acute organophosphate poisoning. Organophosphates 238-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 12507060-10 2002 CONCLUSION: In the acute phase of organophosphate poisoning, low serum acetylcholinesterase (> 50% of minimum normal value) supports the diagnosis of organophosphate poisoning but it does not show a significant relationship to the severity of poisoning (NS). Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 12507060-10 2002 CONCLUSION: In the acute phase of organophosphate poisoning, low serum acetylcholinesterase (> 50% of minimum normal value) supports the diagnosis of organophosphate poisoning but it does not show a significant relationship to the severity of poisoning (NS). Organophosphates 153-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 12507060-11 2002 The serum acetylcholinesterase activity may be a useful parameter in following the acute prognosis of organophosphate poisoning. Organophosphates 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 11842237-1 2002 To detect traces of insecticides in the environment using biosensors, we engineered Drosophila acetylcholinesterase (AChE) to increase its sensitivity and its rate of phosphorylation or carbamoylation by organophosphates or carbamates. Organophosphates 204-220 Acetylcholine esterase Drosophila melanogaster 95-115 11842237-1 2002 To detect traces of insecticides in the environment using biosensors, we engineered Drosophila acetylcholinesterase (AChE) to increase its sensitivity and its rate of phosphorylation or carbamoylation by organophosphates or carbamates. Organophosphates 204-220 Acetylcholine esterase Drosophila melanogaster 117-121 11920913-3 2001 Success has been achieved in endowing BChE with the ability to hydrolyze organophosphates. Organophosphates 73-89 butyrylcholinesterase Homo sapiens 38-42 11718958-2 2001 Lymphocyte neuropathy target esterase (NTE) is thought to have potential as a predictor of organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 91-106 patatin like phospholipase domain containing 6 Homo sapiens 11-37 11718958-2 2001 Lymphocyte neuropathy target esterase (NTE) is thought to have potential as a predictor of organophosphate-induced delayed neuropathy (OPIDN). Organophosphates 91-106 patatin like phospholipase domain containing 6 Homo sapiens 39-42 11920914-5 2001 These observations suggest that peripheral site ligands are capable of allosterically affecting the conformation of residues in the choline binding site of AChE, thus optimizing the position of the leaving group of uncharged organophosphates during the inhibition reaction. Organophosphates 225-241 acetylcholinesterase Mus musculus 156-160 11743808-0 2001 Use of cholinesterase activity in monitoring organophosphate pesticide exposure of cattle produced in tropical areas. Organophosphates 45-60 butyrylcholinesterase Bos taurus 7-21 11743808-1 2001 The use of cholinesterase activity as a biochemical method for monitoring organophosphate pesticide exposure in cattle is described herein. Organophosphates 74-89 butyrylcholinesterase Bos taurus 11-25 11920914-0 2001 Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates. Organophosphates 81-97 acetylcholinesterase Mus musculus 49-69 11602663-1 2001 The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 3.1.1.7) was examined in AChE knockout mice. Organophosphates 21-36 acetylcholinesterase Mus musculus 111-115 11598781-1 2001 Expression of hsp70 in the third-instar larval tissues of transgenic Drosophila melanogaster (hsp70-lacZ) following dietary exposure to organophosphate insecticide chlorpyrifos for various time intervals was investigated. Organophosphates 136-151 Heat-shock-protein-70Ab Drosophila melanogaster 14-19 11846996-4 2001 This study also demonstrated that dimethoate could rapidly induce the expression of c-fos, with a maximal effect at about 40 min, and c-fos might act as a transcriptional factor in regulating the expression of nAChR in the primary skeletal muscle cell culture following organophosphate exposure. Organophosphates 270-285 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 84-89 11563981-1 2001 Acetylcholinesterase (AChE) insensitive to organophosphate and carbamate insecticides has been identified as a major resistance mechanism in numerous arthropod species. Organophosphates 43-58 neuroligin-4, Y-linked Musca domestica 22-26 11846996-4 2001 This study also demonstrated that dimethoate could rapidly induce the expression of c-fos, with a maximal effect at about 40 min, and c-fos might act as a transcriptional factor in regulating the expression of nAChR in the primary skeletal muscle cell culture following organophosphate exposure. Organophosphates 270-285 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 134-139 11846996-4 2001 This study also demonstrated that dimethoate could rapidly induce the expression of c-fos, with a maximal effect at about 40 min, and c-fos might act as a transcriptional factor in regulating the expression of nAChR in the primary skeletal muscle cell culture following organophosphate exposure. Organophosphates 270-285 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 210-215 11677268-0 2001 The catalytic domain of human neuropathy target esterase mediates an organophosphate-sensitive ionic conductance across liposome membranes. Organophosphates 69-84 patatin like phospholipase domain containing 6 Homo sapiens 30-56 11783861-6 2001 Screening showed 20-69% of 582 Hmong adults with risky or unsafe levels of cholinesterase inhibition, an indicator of exposure to organophosphate and carbamate pesticides. Organophosphates 130-145 butyrylcholinesterase Homo sapiens 75-89 11677268-1 2001 In humans and other vertebrates, reaction of organophosphates with a neuronal membrane protein, neuropathy target esterase (NTE), initiates events which culminate in axonal degeneration. Organophosphates 45-61 patatin like phospholipase domain containing 6 Homo sapiens 96-122 11677268-1 2001 In humans and other vertebrates, reaction of organophosphates with a neuronal membrane protein, neuropathy target esterase (NTE), initiates events which culminate in axonal degeneration. Organophosphates 45-61 patatin like phospholipase domain containing 6 Homo sapiens 124-127 11677268-9 2001 Future work may establish whether NTE itself mediates an organophosphate-sensitive ion flux across intracellular membranes within intact cells. Organophosphates 57-72 patatin like phospholipase domain containing 6 Homo sapiens 34-37 11511334-1 2001 INTRODUCTION: Organophosphate (OP) insecticides inhibit both cholinesterase and pseudo-cholinesterase activities. Organophosphates 14-29 butyrylcholinesterase Homo sapiens 61-75 11544037-0 2001 Amperometric microbial biosensor for direct determination of organophosphate pesticides using recombinant microorganism with surface expressed organophosphorus hydrolase. Organophosphates 61-76 acylaminoacyl-peptide hydrolase Homo sapiens 143-169 11511334-1 2001 INTRODUCTION: Organophosphate (OP) insecticides inhibit both cholinesterase and pseudo-cholinesterase activities. Organophosphates 14-29 butyrylcholinesterase Homo sapiens 80-101 11577800-0 2001 Acetylcholinesterase inhibition and the extrapyramidal syndrome: a review of the neurotoxicity of organophosphate. Organophosphates 98-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12018584-0 2001 Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Organophosphates 89-104 monoamine oxidase A Rattus norvegicus 57-60 12018584-1 2001 Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. Organophosphates 0-15 monoamine oxidase A Rattus norvegicus 116-121 12018584-1 2001 Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. Organophosphates 0-15 monoamine oxidase B Rattus norvegicus 126-131 12018584-3 2001 MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO. Organophosphates 45-61 monoamine oxidase B Rattus norvegicus 0-5 12018584-3 2001 MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO. Organophosphates 45-61 monoamine oxidase A Rattus norvegicus 0-3 11577800-2 2001 Acute cholinergic crisis caused by the inhibition of synaptic acetylcholinesterase is the major manifestation of organophosphate poisoning and may cause death within minutes. Organophosphates 113-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 11548114-1 2001 The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain. Organophosphates 91-106 butyrylcholinesterase Rattus norvegicus 201-215 11452140-1 2001 Certain esterase inhibitors protect from organophosphate-induced delayed polyneuropathy (OPIDP) when given before a neuropathic organophosphate by inhibiting neuropathy target esterase (NTE). Organophosphates 41-56 patatin-like phospholipase domain containing 6 Rattus norvegicus 158-184 11452140-1 2001 Certain esterase inhibitors protect from organophosphate-induced delayed polyneuropathy (OPIDP) when given before a neuropathic organophosphate by inhibiting neuropathy target esterase (NTE). Organophosphates 41-56 patatin-like phospholipase domain containing 6 Rattus norvegicus 186-189 11548114-1 2001 The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain. Organophosphates 91-106 butyrylcholinesterase Rattus norvegicus 217-220 11548114-1 2001 The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain. Organophosphates 91-106 acetylcholinesterase Rattus norvegicus 292-312 11548114-1 2001 The purpose of the present study was to determine the effect of two different doses of the organophosphate insecticide O,O"-diethyl-O-3,5,6-trichloro-2-pyridylphosphorothionate [chlorpyrifos (CPF)], a cholinesterase (ChE) inhibitor, in the plus-maze test of anxiety in the rat, as well as on acetylcholinesterase (AChE) activity in the brain. Organophosphates 91-106 acetylcholinesterase Rattus norvegicus 314-318 11453739-1 2001 Understanding reaction pathways of phosphylation, reactivation, and "aging" of AChE with toxic organophosphate compounds is both a biochemical and a pharmacological challenge. Organophosphates 95-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 11453739-7 2001 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. Organophosphates 155-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 11530837-1 2001 Parasuicide by ingestion of organophosphate (OP) insecticides is common in Sri Lanka, but the use of the parateral route to self administer the poison is extremely rare. Organophosphates 28-43 sorcin Homo sapiens 75-78 11266077-1 2001 Serum paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect low-density lipoprotein (LDL) against oxidation. Organophosphates 112-128 serum paraoxonase/arylesterase 1 Oryctolagus cuniculus 0-17 11432431-6 2001 The most appropriate dosage regimen for 2-PAM in the treatment of organophosphate toxicity in buffaloes would be 25 mg/kg followed by 22 mg/kg at 8 h intervals. Organophosphates 66-81 peptidylglycine alpha-amidating monooxygenase Bos taurus 42-45 11334332-1 2001 Obidoxime is an antidote approved for reactivation of inhibited acetylcholinesterase in organophosphate poisoning. Organophosphates 88-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11248451-3 2001 Poisoning with organophosphate pesticides and arsenic (ingestion) showed a second grade SP-A score. Organophosphates 15-30 surfactant protein A2 Homo sapiens 88-92 11223004-1 2001 Organophosphates (OPs) inhibit acetylcholinesterase (AChE) activity causing cholinergic stimulation in the central nervous system (CNS). Organophosphates 0-16 acetylcholinesterase Rattus norvegicus 31-51 11223004-1 2001 Organophosphates (OPs) inhibit acetylcholinesterase (AChE) activity causing cholinergic stimulation in the central nervous system (CNS). Organophosphates 0-16 acetylcholinesterase Rattus norvegicus 53-57 11223004-1 2001 Organophosphates (OPs) inhibit acetylcholinesterase (AChE) activity causing cholinergic stimulation in the central nervous system (CNS). Organophosphates 18-21 acetylcholinesterase Rattus norvegicus 31-51 11223004-1 2001 Organophosphates (OPs) inhibit acetylcholinesterase (AChE) activity causing cholinergic stimulation in the central nervous system (CNS). Organophosphates 18-21 acetylcholinesterase Rattus norvegicus 53-57 11239953-1 2001 Two up-to-date known paraoxonase 1 (PON1) polymorphisms (Gln--Arg 191 and Leu--Met 54) affect the hydrolysis of toxic oxons and might intensify effects of pollutants, organophosphates and other environmental chemicals in development of Parkinson"s disease (PD). Organophosphates 167-183 paraoxonase 1 Homo sapiens 21-34 11239953-1 2001 Two up-to-date known paraoxonase 1 (PON1) polymorphisms (Gln--Arg 191 and Leu--Met 54) affect the hydrolysis of toxic oxons and might intensify effects of pollutants, organophosphates and other environmental chemicals in development of Parkinson"s disease (PD). Organophosphates 167-183 paraoxonase 1 Homo sapiens 36-40 11399807-0 2001 Re: androgen receptor antagonism by the organophosphate insecticide fenitrothion. Organophosphates 40-55 androgen receptor Homo sapiens 4-21 11353139-1 2001 Diazinon, an organophosphate pesticide, becomes biotransformed to a more potent oxon metabolite that inhibits acetylcholinesterase (AChE). Organophosphates 13-28 acetylcholinesterase Oryzias latipes 132-136 11350209-1 2001 The specific hydrolytic activity of PON1 paraoxonase/arylesterase enzymes in liver and blood provides a natural barrier against the entry of organophosphate toxins into the central and peripheral nervous systems. Organophosphates 141-156 paraoxonase 1 Mus musculus 36-40 11350209-2 2001 Inherited differences in PON1 enzyme concentrations may determine levels of susceptibility to organophosphate injury in humans. Organophosphates 94-109 paraoxonase 1 Homo sapiens 25-29 11350209-6 2001 These findings indicate that boosting serum levels of PON1 enzymes by a gene delivery vector raises the threshold for organophosphate toxicity by hydrolytic destruction before the chemical can enter the brain. Organophosphates 118-133 paraoxonase 1 Mus musculus 54-58 11393267-0 2001 Neuroparalysis and oxime efficacy in organophosphate poisoning: a study of butyrylcholinesterase. Organophosphates 37-52 butyrylcholinesterase Homo sapiens 75-96 11393267-5 2001 Reactivation potentials of BuChE (the difference between oxime-reactivated and -unreactivated enzyme activity) declined significantly with time after organophosphate ingestion. Organophosphates 150-165 butyrylcholinesterase Homo sapiens 27-32 11266077-1 2001 Serum paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect low-density lipoprotein (LDL) against oxidation. Organophosphates 112-128 serum paraoxonase/arylesterase 1 Oryctolagus cuniculus 19-23 11222873-0 2001 Androgen receptor antagonism by the organophosphate insecticide fenitrothion. Organophosphates 36-51 androgen receptor Homo sapiens 0-17 11222865-0 2001 Organophosphate antagonism of the androgen receptor. Organophosphates 0-15 androgen receptor Homo sapiens 34-51 11218047-1 2001 Both organophosphate (OP) and carbamate pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (AChE) and subsequent excess of acetylcholine (ACh). Organophosphates 5-20 acetylcholinesterase Mus musculus 123-143 11158237-9 2001 Since TO:CP is the most neuropathic of the isomers of TCP in vivo, differentiating N2a cells provide a useful cellular system for mechanistic studies of the neurodegenerative effects of this organophosphate. Organophosphates 191-206 secretoglobin, family 1B, member 27 Mus musculus 54-57 11205075-3 2001 These clinical manifestations occur from liposoluble organophosphates or metabolites with long-lasting half time, causeing delayed inhibition of acetylcholinesterase and subsequent burn out of the neuromuscular junction from acetylcholine overstimulation. Organophosphates 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 11218047-1 2001 Both organophosphate (OP) and carbamate pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (AChE) and subsequent excess of acetylcholine (ACh). Organophosphates 5-20 acetylcholinesterase Mus musculus 145-149 10996660-5 2000 The available data indicate that experimental data for most organophosphates evaluated are limited; most organophosphates are equally potent RBC AChE inhibitors in different mammalian species; NOELs from repeated exposure studies of variable duration are usually equivalent; and, no particular grouping based on organophosphate structure is consistently more potent than another. Organophosphates 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 11163034-0 2001 Novel test and its automation for the determination of erythrocyte acetylcholinesterase and its application to organophosphate exposure. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 11163034-6 2001 Acetylcholinesterase values were in the range of 0-14 UgHb(-1) in cases of organophosphate poisoning, in contrast with normal controls, who had AChE values of 24.4--37.9 UgHb(-1). Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11527224-6 2001 The clinical diagnosis of organophosphate poisoning was confirmed by reduced levels of erythrocytes and plasma cholinesterase and the presence of methamidophos in the vegetable leftovers. Organophosphates 26-41 butyrylcholinesterase Homo sapiens 111-125 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Organophosphates 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Organophosphates 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 11053548-0 2000 Interactions of the organophosphates paraoxon and methyl paraoxon with mouse brain acetylcholinesterase. Organophosphates 20-36 acetylcholinesterase Mus musculus 83-103 11053548-2 2000 The bimolecular inhibition rate constant k(i) has been used for decades to describe the inhibitory capacity of organophosphates toward acetylcholinesterase. Organophosphates 111-127 acetylcholinesterase Mus musculus 135-155 11053548-6 2000 These data suggested that the current understanding of how these organophosphates interact with acetylcholinesterase is incomplete. Organophosphates 65-81 acetylcholinesterase Mus musculus 96-116 11339619-1 2001 OBJECTIVE: The aim of the study was to find whether continuous pralidoxime (2-PAM) infusion along with aggressive atropinisation improves the outcome in patients with severe organophosphate poisoning who require assisted ventilation. Organophosphates 174-189 peptidylglycine alpha-amidating monooxygenase Homo sapiens 78-81 11696925-0 2001 QSAR for the organophosphate-induced inhibition and "aging" of the enzyme neuropathy target esterase (NTE). Organophosphates 13-28 patatin like phospholipase domain containing 6 Homo sapiens 74-100 11696925-0 2001 QSAR for the organophosphate-induced inhibition and "aging" of the enzyme neuropathy target esterase (NTE). Organophosphates 13-28 patatin like phospholipase domain containing 6 Homo sapiens 102-105 11023690-7 2000 This compound, besides inhibiting the target of organophosphates, AChE, also inhibited different ATPases, suggesting both synaptic transmission and nerve conduction were affected. Organophosphates 48-64 acetylcholinesterase Rattus norvegicus 66-70 10964798-4 2000 We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein. Organophosphates 73-88 steroidogenic acute regulatory protein Mus musculus 193-223 10964798-4 2000 We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein. Organophosphates 73-88 steroidogenic acute regulatory protein Mus musculus 225-229 12935443-5 2000 These results indicate that administration of organophosphate can decrease AChE and nAChR expression in the neuromuscular junction, and are suggestive of multiple mechanisms of down-regulation of both AChE and nAChR, some of which might involve alterations at the transcriptional level. Organophosphates 46-61 acetylcholinesterase Rattus norvegicus 75-79 12935443-5 2000 These results indicate that administration of organophosphate can decrease AChE and nAChR expression in the neuromuscular junction, and are suggestive of multiple mechanisms of down-regulation of both AChE and nAChR, some of which might involve alterations at the transcriptional level. Organophosphates 46-61 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 84-89 12935443-5 2000 These results indicate that administration of organophosphate can decrease AChE and nAChR expression in the neuromuscular junction, and are suggestive of multiple mechanisms of down-regulation of both AChE and nAChR, some of which might involve alterations at the transcriptional level. Organophosphates 46-61 acetylcholinesterase Rattus norvegicus 201-205 12935443-5 2000 These results indicate that administration of organophosphate can decrease AChE and nAChR expression in the neuromuscular junction, and are suggestive of multiple mechanisms of down-regulation of both AChE and nAChR, some of which might involve alterations at the transcriptional level. Organophosphates 46-61 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 210-215 12935443-8 2000 Although the functions of either of these enolases are not completely established, up-regulation of NSE mRNA may be a marker for the nervous system abnormality following organophosphate exposure. Organophosphates 170-185 enolase 2 Rattus norvegicus 100-103 10898114-12 2000 PON1 status, which includes PON1 level as well as PON1192 genotype, may be a better predictor for cardiovascular disease or organophosphate susceptibility than PON1 genotype alone. Organophosphates 124-139 paraoxonase 1 Homo sapiens 0-4 10928685-1 2000 Organophosphate and carbamate ester insecticides, main causes of pesticide poisoning, inhibit cholinesterase (ChE) enzymes. Organophosphates 0-15 butyrylcholinesterase Canis lupus familiaris 94-108 10928685-1 2000 Organophosphate and carbamate ester insecticides, main causes of pesticide poisoning, inhibit cholinesterase (ChE) enzymes. Organophosphates 0-15 butyrylcholinesterase Canis lupus familiaris 110-113 10869180-13 2000 This inhibitory effect, measured by the relative decrease in the first-order phosphorylation rate constant k(OP) for the neutral organophosphate 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC) that resulted from fasciculin binding, decreased from 0.002 in wild-type human AChE to 0.24 in the D74G mutant. Organophosphates 129-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 280-284 10869390-0 2000 Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase. Organophosphates 54-69 acetylcholinesterase Mus musculus 100-120 11286337-0 2000 Improved multianalyte detection of organophosphates and carbamates with disposable multielectrode biosensors using recombinant mutants of Drosophila acetylcholinesterase and artificial neural networks. Organophosphates 35-51 Acetylcholine esterase Drosophila melanogaster 149-169 10677395-1 2000 Human serum paraoxonase 1 (PON1) is located on high-density lipoprotein and has been implicated in the detoxification of organophosphates, and possibly in the prevention of lipid peroxidation of low-density lipoprotein. Organophosphates 121-137 paraoxonase 1 Homo sapiens 12-25 10801325-1 2000 Organophosphates inactivate acetylcholinesterase by reacting covalently with the active center serine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10720708-3 2000 The target of promotion is unknown but there are indications that it might be similar and/or linked to neuropathy target esterase (NTE), which is the molecular target of organophosphate-induced delayed polyneuropathy (OPIDP). Organophosphates 170-185 patatin like phospholipase domain containing 6 Homo sapiens 103-129 10720708-3 2000 The target of promotion is unknown but there are indications that it might be similar and/or linked to neuropathy target esterase (NTE), which is the molecular target of organophosphate-induced delayed polyneuropathy (OPIDP). Organophosphates 170-185 patatin like phospholipase domain containing 6 Homo sapiens 131-134 10817663-1 2000 The reactivation of organophosphate-inhibited acetylcholinesterase (AChE) by oximes inevitably results in the formation of highly reactive phosphoryloximes (POX), which are able to re-inhibit the enzyme. Organophosphates 20-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 10677395-1 2000 Human serum paraoxonase 1 (PON1) is located on high-density lipoprotein and has been implicated in the detoxification of organophosphates, and possibly in the prevention of lipid peroxidation of low-density lipoprotein. Organophosphates 121-137 paraoxonase 1 Homo sapiens 27-31 10810102-7 2000 Symptoms reported during the high exposure period, were initially clustered in broader symptom categories from reference literature on health effects of pesticides that inhibit cholinesterase (organophosphate and carbamate). Organophosphates 193-208 butyrylcholinesterase Homo sapiens 177-191 10641290-2 1999 Biosensors for organophosphates in solution may be constructed by monitoring the activity of acetylcholinesterase (AChE) or organophosphate hydrolase (OPH) immobilized to a variety of microsensor platforms. Organophosphates 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 10640712-1 2000 The Drosophila neurodegeneration gene swiss-cheese encodes a neuronal protein apparently involved in glia-neuron interaction and is homologous to human NTE, the molecular target of organophosphate-induced neuropathy. Organophosphates 181-196 patatin like phospholipase domain containing 6 Homo sapiens 152-155 10641290-2 1999 Biosensors for organophosphates in solution may be constructed by monitoring the activity of acetylcholinesterase (AChE) or organophosphate hydrolase (OPH) immobilized to a variety of microsensor platforms. Organophosphates 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 10433700-1 1999 Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) is a key objective in the treatment of OP poisoning. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 10511255-8 1999 Biomarkers of renal effects of cadmium, lead effects on haemoglobin synthesis and organophosphate effects on cholinesterase activities have been well validated and are widely used in routine monitoring activities. Organophosphates 82-97 butyrylcholinesterase Homo sapiens 109-123 10448123-0 1999 Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: toxicological relevance of cholinesterase-independent actions. Organophosphates 26-41 butyrylcholinesterase Homo sapiens 148-162 10529460-1 1999 Determination of erythrocyte acetylcholinesterase (AChE) activity is the appropriate tool for the diagnosis of organophosphate exposure and intoxication. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 10529460-1 1999 Determination of erythrocyte acetylcholinesterase (AChE) activity is the appropriate tool for the diagnosis of organophosphate exposure and intoxication. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 10529460-9 1999 This modified approach provides a simple way for sensitive and precise determination of AChE activity in whole blood in the presence of organophosphates even with low-tech equipment. Organophosphates 136-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 10470002-1 1999 BACKGROUND: Serum paraoxonase has been associated with the metabolism of organophosphate pesticides in humans. Organophosphates 73-88 paraoxonase 1 Homo sapiens 18-29 10433700-1 1999 Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) is a key objective in the treatment of OP poisoning. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 10421474-1 1999 In recent years several lines of evidence have indicated that serum paraoxonase (PON1), and perhaps other mammalian paraoxonases, act as important guardians against cellular damage from toxic agents, such as organophosphates, oxidized lipids in the plasma low density lipoproteins (LDL), and against bacterial endotoxins. Organophosphates 208-224 paraoxonase 1 Homo sapiens 81-85 10421452-0 1999 Organophosphate inhibition of human heart muscle cholinesterase isoenzymes. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 49-63 10447555-1 1999 Neuropathy target esterase (NTE), the putative target enzyme for organophosphate induced delayed polyneuropathy (OPIDP), can be measured in lymphocytes but has rarely been assessed in acute human poisoning. Organophosphates 65-80 patatin like phospholipase domain containing 6 Homo sapiens 0-26 10447555-1 1999 Neuropathy target esterase (NTE), the putative target enzyme for organophosphate induced delayed polyneuropathy (OPIDP), can be measured in lymphocytes but has rarely been assessed in acute human poisoning. Organophosphates 65-80 patatin like phospholipase domain containing 6 Homo sapiens 28-31 10373401-1 1999 Human serum paraoxonase 1 (PON1) catalyzes the hydrolysis of certain organophosphate pesticides and nerve gases and so may alter significantly an individual"s susceptibility to the toxicity of these chemicals. Organophosphates 69-84 paraoxonase 1 Homo sapiens 12-25 10373401-1 1999 Human serum paraoxonase 1 (PON1) catalyzes the hydrolysis of certain organophosphate pesticides and nerve gases and so may alter significantly an individual"s susceptibility to the toxicity of these chemicals. Organophosphates 69-84 paraoxonase 1 Homo sapiens 27-31 10442677-4 1999 For example, the PON1 gene product is serum paraoxonase, which is expressed mainly in the liver and which hydrolyzes organophosphates. Organophosphates 117-133 paraoxonase 1 Homo sapiens 17-21 10421442-8 1999 Organophosphates equilibrate with AChE prior to phosphorylating the active site serine residue, and as predicted propidium had little effect on the phosphorylation rate constants for the fluorogenic organophosphate ethylmethyl-phosphonylcoumarin (EMPC). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 10421490-1 1999 Covalent modification of NTE, a neuronal protein with serine esterase activity, by certain organophosphates (OP) initiates degeneration of long axons in the peripheral and central nervous system. Organophosphates 91-107 patatin like phospholipase domain containing 6 Homo sapiens 25-28 10421490-6 1999 The integrity of NTE would be severely compromised by the presence of a negatively-charged organophosphate moiety at this site. Organophosphates 91-106 patatin like phospholipase domain containing 6 Homo sapiens 17-20 10421494-0 1999 A stable preparation of hen brain neuropathy target esterase for rapid biochemical assessment of neurotoxic potential of organophosphates. Organophosphates 121-137 patatin like phospholipase domain containing 6 Homo sapiens 34-60 10421494-1 1999 Neuropathy target esterase (NTE) is a molecular target for organophosphate-induced delayed neurotoxicity (OPIDN). Organophosphates 59-74 patatin like phospholipase domain containing 6 Homo sapiens 0-26 10421494-1 1999 Neuropathy target esterase (NTE) is a molecular target for organophosphate-induced delayed neurotoxicity (OPIDN). Organophosphates 59-74 patatin like phospholipase domain containing 6 Homo sapiens 28-31 10421494-2 1999 This enzyme has proved to be an excellent tool for the assessment of neuropathic potential of organophosphates (OP), in particular by comparison of an OP inhibitory activity in vitro against NTE and acetylcholinesterase. Organophosphates 94-110 patatin like phospholipase domain containing 6 Homo sapiens 191-194 10421471-5 1999 Slices were exposed to either organophosphate or cabamate anti-ChEs, both of which induced within 10 min excessive overexpression of the mRNA encoding the immediate early response transcription factor c-Fos. Organophosphates 30-45 FBJ osteosarcoma oncogene Mus musculus 201-206 10421473-5 1999 Organophosphates being long-acting active site inhibitors of AChE were chosen for this study. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 10421494-2 1999 This enzyme has proved to be an excellent tool for the assessment of neuropathic potential of organophosphates (OP), in particular by comparison of an OP inhibitory activity in vitro against NTE and acetylcholinesterase. Organophosphates 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 10421495-1 1999 Neuropathy target esterase (NTE) was shown to be an excellent biochemical marker for screening of organophosphates (OPs) with respect to their ability to result in organophosphate induced delayed neurotoxicity (OPIDN). Organophosphates 98-114 patatin like phospholipase domain containing 6 Homo sapiens 0-26 10421495-1 1999 Neuropathy target esterase (NTE) was shown to be an excellent biochemical marker for screening of organophosphates (OPs) with respect to their ability to result in organophosphate induced delayed neurotoxicity (OPIDN). Organophosphates 98-114 patatin like phospholipase domain containing 6 Homo sapiens 28-31 10421495-1 1999 Neuropathy target esterase (NTE) was shown to be an excellent biochemical marker for screening of organophosphates (OPs) with respect to their ability to result in organophosphate induced delayed neurotoxicity (OPIDN). Organophosphates 116-119 patatin like phospholipase domain containing 6 Homo sapiens 0-26 10421495-1 1999 Neuropathy target esterase (NTE) was shown to be an excellent biochemical marker for screening of organophosphates (OPs) with respect to their ability to result in organophosphate induced delayed neurotoxicity (OPIDN). Organophosphates 116-119 patatin like phospholipase domain containing 6 Homo sapiens 28-31 10421495-1 1999 Neuropathy target esterase (NTE) was shown to be an excellent biochemical marker for screening of organophosphates (OPs) with respect to their ability to result in organophosphate induced delayed neurotoxicity (OPIDN). Organophosphates 98-113 patatin like phospholipase domain containing 6 Homo sapiens 0-26 10421495-1 1999 Neuropathy target esterase (NTE) was shown to be an excellent biochemical marker for screening of organophosphates (OPs) with respect to their ability to result in organophosphate induced delayed neurotoxicity (OPIDN). Organophosphates 98-113 patatin like phospholipase domain containing 6 Homo sapiens 28-31 10421475-1 1999 Serum paraoxonase (PON1) hydrolyses organophosphate (OP) insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. Organophosphates 36-51 paraoxonase 1 Homo sapiens 19-23 10421496-0 1999 Kinetic parameters of cholinesterase interactions with organophosphates: retrieval and comparison tools available through ESTHER database: ESTerases, alpha/beta Hydrolase Enzymes and Relatives. Organophosphates 55-71 butyrylcholinesterase Homo sapiens 22-36 10421475-3 1999 The 192 polymorphism is the major determinant of the PON1 activity polymorphism towards organophosphates. Organophosphates 88-104 paraoxonase 1 Homo sapiens 53-57 10421497-0 1999 Estimation of inhibitory organophosphates with purified pig liver carboxylesterase. Organophosphates 25-41 LOC100737013 Sus scrofa 60-82 10421497-1 1999 Organophosphates that inhibit acetylcholinesterase normally also inhibit pig liver carboxylesterase irreversibly. Organophosphates 0-16 LOC100737013 Sus scrofa 77-99 10421480-0 1999 The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Organophosphates 54-70 paraoxonase 1 Homo sapiens 12-23 10421480-0 1999 The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Organophosphates 54-70 paraoxonase 1 Homo sapiens 25-29 10421480-4 1999 Our experiments with a mouse model system have convincingly shown that PON1 plays a major role in the detoxication of organophosphate (OP) compounds processed through the P450/PON1 pathway. Organophosphates 118-133 paraoxonase 1 Mus musculus 71-75 10421480-4 1999 Our experiments with a mouse model system have convincingly shown that PON1 plays a major role in the detoxication of organophosphate (OP) compounds processed through the P450/PON1 pathway. Organophosphates 118-133 paraoxonase 1 Mus musculus 176-180 10421484-4 1999 The ChE-sponges, which can be molded to any form, can effectively be used to remove and decontaminate organophosphates (OPs) from surfaces, biological (skin or wounds) or otherwise (clothing or sensitive medical equipment), or the environment. Organophosphates 102-118 butyrylcholinesterase Homo sapiens 4-7 10421484-4 1999 The ChE-sponges, which can be molded to any form, can effectively be used to remove and decontaminate organophosphates (OPs) from surfaces, biological (skin or wounds) or otherwise (clothing or sensitive medical equipment), or the environment. Organophosphates 120-123 butyrylcholinesterase Homo sapiens 4-7 10230391-1 1999 This document presents a revised framework for conducting worker and dietary risk assessments for less-than-lifetime exposures to organophosphate or carbamate pesticides based on red blood cell (RBC) or brain acetylcholinesterase (AChE) inhibition or the presence of clinical signs and symptoms. Organophosphates 130-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 10887566-1 1999 Resistance of Culex quinquefasciatus from Miranda, Venezuela to the organophosphate insecticides malathion and chlorpirifos was higher than 30x whereas resistance to pyrethroids metylpirimifos, fention, cipametrine, deltametrine, permetrine and lambdacyalotrine and to organochlorate DDT was lower than 4x. Organophosphates 68-83 interaptin Culex quinquefasciatus 42-49 9763535-1 1998 These PON allozymes hydrolyze organophosphates and aromatic esters, and both also protect LDL from copper ion-induced oxidation. Organophosphates 30-46 paraoxonase 1 Homo sapiens 6-9 10085081-4 1999 Kinetic rate constants were determined for the phosphorylation of AChE by two fluorogenic organophosphates, 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide (DEPQ) and 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC), by monitoring release of the fluorescent leaving group. Organophosphates 90-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 10085081-7 1999 Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates. Organophosphates 113-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 10085081-7 1999 Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates. Organophosphates 113-129 serine peptidase inhibitor, Kunitz type 2 Homo sapiens 76-79 10085081-7 1999 Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates. Organophosphates 113-129 serine peptidase inhibitor, Kunitz type 2 Homo sapiens 80-83 9930975-9 1999 The inactivation of acetylcholinesterase with the same series of organophosphate nerve agents was also measured. Organophosphates 65-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 11233155-8 1999 Whereas antioxidants can prevent the formation of Ox-LDL, human serum paraoxonase (PON 1), an HDL-associated esterase that hydrolyzes organophosphates, can eliminate oxidized LDL (by hydrolysis of its lipid peroxides), which is formed when antioxidant protection is not sufficient. Organophosphates 134-150 paraoxonase 1 Mus musculus 83-88 10022255-3 1998 Our findings reveal exceptionally high resistance of Xenopus AChE to carbamate, organophosphate and quaternary anticholinesterases. Organophosphates 80-95 acetylcholinesterase (Cartwright blood group) L homeolog Xenopus laevis 61-65 11939005-3 1999 These results indicated that c-fos might act as transcription factor and regulate other gene expression during the early period of organophosphate intoxication. Organophosphates 131-146 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 29-34 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Organophosphates 174-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 9863768-0 1998 Effect of organophosphate administration on the expression of pro-opiomelanocortin-derived peptides in motoneurones. Organophosphates 10-25 pro-opiomelanocortin-alpha Mus musculus 62-82 9863768-6 1998 It reached a peak at 24 h but had returned to normal by 48 h. The results indicate that organophosphates can increase the expression of POMC-derived peptides in motoneurones whether the compounds cross the blood-brain barrier freely or not. Organophosphates 88-104 pro-opiomelanocortin-alpha Mus musculus 136-140 9863774-0 1998 Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). Organophosphates 0-15 acetylcholinesterase Oryzias latipes 24-44 9863774-2 1998 Since organophosphates (OPs) inhibit acetylcholinesterase (AChE), the present study examined the effects of diazinon on the embryonic nervous system of a model teleost, medaka, Oryzias latipes. Organophosphates 6-22 acetylcholinesterase Oryzias latipes 59-63 9863774-2 1998 Since organophosphates (OPs) inhibit acetylcholinesterase (AChE), the present study examined the effects of diazinon on the embryonic nervous system of a model teleost, medaka, Oryzias latipes. Organophosphates 24-27 acetylcholinesterase Oryzias latipes 37-57 9863774-2 1998 Since organophosphates (OPs) inhibit acetylcholinesterase (AChE), the present study examined the effects of diazinon on the embryonic nervous system of a model teleost, medaka, Oryzias latipes. Organophosphates 24-27 acetylcholinesterase Oryzias latipes 59-63 9891917-8 1998 Statistically significant inhibition of at least two of the three cholinesterase enzymes (PChe, RChe, or BChe) was observed on gestation day 16, 24 h following exposure, with all of the organophosphates tested. Organophosphates 186-202 butyrylcholinesterase Rattus norvegicus 66-80 9891917-8 1998 Statistically significant inhibition of at least two of the three cholinesterase enzymes (PChe, RChe, or BChe) was observed on gestation day 16, 24 h following exposure, with all of the organophosphates tested. Organophosphates 186-202 butyrylcholinesterase Rattus norvegicus 105-109 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-59 butyrylcholinesterase Rattus norvegicus 95-109 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-59 butyrylcholinesterase Rattus norvegicus 198-212 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-59 butyrylcholinesterase Rattus norvegicus 198-212 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-59 butyrylcholinesterase Rattus norvegicus 339-343 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-59 butyrylcholinesterase Rattus norvegicus 198-212 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-58 butyrylcholinesterase Rattus norvegicus 95-109 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-58 butyrylcholinesterase Rattus norvegicus 198-212 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-58 butyrylcholinesterase Rattus norvegicus 198-212 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-58 butyrylcholinesterase Rattus norvegicus 339-343 9891917-12 1998 These results demonstrate that for the six organophosphates tested: (1) inhibition of maternal cholinesterase activity was the most sensitive indicator of organophosphate exposure; (2) the level of cholinesterase inhibition associated with clinical findings was always greater than 20%; and (3) no effect on fetal cholinesterase activity (BChe) was observed, even at dose levels that continued to demonstrate significant inhibition of maternal cholinesterase activity. Organophosphates 43-58 butyrylcholinesterase Rattus norvegicus 198-212 9703197-4 1998 PON1 hydrolyzes organophosphate (OP) insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. Organophosphates 16-31 paraoxonase 1 Homo sapiens 0-4 9587020-8 1998 The reactivation of human AChE by oximes was dependent on the organophosphate used. Organophosphates 62-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9707642-2 1998 Mutations that eliminate Prf show a loss of both Pto resistance and sensitivity to the organophosphate insecticide fenthion, suggesting that Prf controls both phenotypes. Organophosphates 87-102 putative late blight resistance protein homolog R1A-4 Solanum lycopersicum 25-28 9707642-2 1998 Mutations that eliminate Prf show a loss of both Pto resistance and sensitivity to the organophosphate insecticide fenthion, suggesting that Prf controls both phenotypes. Organophosphates 87-102 putative late blight resistance protein homolog R1A-4 Solanum lycopersicum 141-144 9712341-1 1998 Human serum paraoxonase (PON1) is located on high density lipoprotein and has been implicated in the detoxification of organophosphates and possibly in the prevention of low density lipoprotein lipid peroxidation. Organophosphates 119-135 paraoxonase 1 Homo sapiens 25-29 9712341-9 1998 Low serum PON1 activity in NIDDM may be related to an increased tendency to lipid peroxidation and may also increase susceptibility to toxicity from organophosphate exposure. Organophosphates 149-164 paraoxonase 1 Homo sapiens 10-14 9739487-1 1998 Paraoxonase (PON1) hydrolyses organophosphate insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. Organophosphates 30-45 paraoxonase 1 Homo sapiens 0-11 9739487-1 1998 Paraoxonase (PON1) hydrolyses organophosphate insecticides and nerve gases and is responsible for determining the selective toxicity of these compounds in mammals. Organophosphates 30-45 paraoxonase 1 Homo sapiens 13-17 9739487-3 1998 The 192 polymorphism is the major determinant of the PON1 activity polymorphism towards organophosphates. Organophosphates 88-104 paraoxonase 1 Homo sapiens 53-57 9631435-1 1998 Chronic (2 day) exposure of human neuroblastoma cells to the organophosphate pesticide phosmet induced a marked concentration-dependent increase in the levels of PrP present on the cell surface as assessed by biotin labelling and immunoprecipitation. Organophosphates 61-76 prion protein Homo sapiens 162-165 9685159-1 1998 Serum paraoxonase (PON1) is an esterase that is associated with high-density lipoproteins (HDLs) in the plasma; it is involved in the detoxification of organophosphate insecticides such as parathion and chlorpyrifos. Organophosphates 152-167 paraoxonase 1 Mus musculus 19-23 9547363-1 1998 Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes is the primary reason for their effectiveness in the treatment of OP poisoning. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 9597732-0 1998 Engineering sensitive acetylcholinesterase for detection of organophosphate and carbamate insecticides. Organophosphates 60-75 Acetylcholine esterase Drosophila melanogaster 22-42 9466418-2 1998 In this study we aimed to define the cellular distribution of neuropathy target esterase, the primary target protein for neuropathic organophosphates. Organophosphates 133-149 patatin like phospholipase domain containing 6 Gallus gallus 62-88 9624271-8 1998 RESULTS: Cumulative lifetime exposure as measured in kg organophosphate exposure, was significantly associated with erythrocyte cholinesterase concentrations (partial r2 = 5%; p < 0.01), controlled for a range of confounders. Organophosphates 56-71 butyrylcholinesterase Homo sapiens 128-142 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 9597732-3 1998 It appears that insect acetylcholinesterase is more susceptible to a broad range of organophosphates and carbamates insecticides than the other tested enzymes. Organophosphates 84-100 Acetylcholine esterase Drosophila melanogaster 23-43 9448738-1 1998 Reactivation of inhibited acetylcholinesterase (AChE) is essential for rapid recovery after organophosphate (OP) poisoning. Organophosphates 92-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 9427520-6 1997 In vivo suppression of the acetylcholine hydrolyzing activity of AChE and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. Organophosphates 207-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 9448738-1 1998 Reactivation of inhibited acetylcholinesterase (AChE) is essential for rapid recovery after organophosphate (OP) poisoning. Organophosphates 92-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 9570306-0 1998 Poverty, production, and health: inhibition of erythrocyte cholinesterase via occupational exposure to organophosphate insecticides in Chiapas, Mexico. Organophosphates 103-118 butyrylcholinesterase Homo sapiens 59-73 9570306-1 1998 Occupational exposure to organophosphate pesticides and its effects on the concentration of erythrocyte cholinesterase in the rural population of Chiapas, Mexico, are described. Organophosphates 25-40 butyrylcholinesterase Homo sapiens 104-118 9518173-2 1997 These organophosphates were separated on plates with three different developing systems within 6-18 min and detected by means of ultraviolet radiation and coloring reactions with 4-(4-nitrobenzyl)pyridine-tetraethylenepentamine reagent (NT reagent) or palladium chloride reagent (PdCl2 reagent). Organophosphates 6-22 phosducin like 2 Homo sapiens 280-285 9456080-2 1998 Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), which is the target for organophosphate induced delayed neuropathy, the target for promotion is unlikely to be NTE. Organophosphates 109-124 patatin like phospholipase domain containing 6 Gallus gallus 51-77 9456080-2 1998 Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), which is the target for organophosphate induced delayed neuropathy, the target for promotion is unlikely to be NTE. Organophosphates 109-124 patatin like phospholipase domain containing 6 Gallus gallus 79-82 10028411-1 1998 Recent data indicate that the neurotoxic effects of organophosphate compounds, including those of the nerve agents VX and sarin, are not solely due to irreversible cholinesterase inhibition. Organophosphates 52-67 butyrylcholinesterase Rattus norvegicus 164-178 9465262-3 1998 Our goal was to ascertain whether differences in AChe sensitivity to an organophosphate (i.e., IC50 values) are due to varying properties of the enzyme molecule (i.e., present assumption) or to extrinsic factors. Organophosphates 72-87 acetylcholinesterase Rattus norvegicus 49-53 9465262-5 1998 AChE IC50 values were determined by incubating tissue homogenates with chlorpyrifos-oxon (active metabolite of chlorpyrifos, a common organophosphate insecticide) for 30 min at 26 degrees C, and then measuring residual AChE activity. Organophosphates 134-149 acetylcholinesterase Rattus norvegicus 0-4 9374188-1 1997 Recent studies have suggested that anticholinesterases including organophosphates and carbamates act directly on the nicotinic acetylcholine receptor (AChR) channel. Organophosphates 65-81 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 117-149 9336338-1 1997 Chlorpyrifos (CPF) is a cholinesterase-inhibiting organophosphate pesticide used extensively to treat crops and domestic animals. Organophosphates 50-65 butyrylcholinesterase Rattus norvegicus 24-38 9374188-1 1997 Recent studies have suggested that anticholinesterases including organophosphates and carbamates act directly on the nicotinic acetylcholine receptor (AChR) channel. Organophosphates 65-81 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 151-155 9220490-1 1997 Cholinesterase inhibitors-the organophosphates and the carbamates-are the most acutely toxic and widely used insecticides. Organophosphates 30-46 butyrylcholinesterase Homo sapiens 0-14 9313934-2 1997 The hydrolysis of organophosphate pesticides (OP) and nerve gases by serum paraoxonase (PON1) is an important factor determining their toxicity to mammals including man. Organophosphates 18-33 paraoxonase 1 Homo sapiens 75-86 9313934-2 1997 The hydrolysis of organophosphate pesticides (OP) and nerve gases by serum paraoxonase (PON1) is an important factor determining their toxicity to mammals including man. Organophosphates 18-33 paraoxonase 1 Homo sapiens 88-92 9314086-1 1997 The plasma cholinesterase (PChE) and red cell acetyl cholinesterase (AChE) activities are indicators of exposure to organophosphates. Organophosphates 116-132 butyrylcholinesterase Homo sapiens 11-25 9314086-1 1997 The plasma cholinesterase (PChE) and red cell acetyl cholinesterase (AChE) activities are indicators of exposure to organophosphates. Organophosphates 116-132 butyrylcholinesterase Homo sapiens 53-67 9192209-1 1997 Organophosphate insecticides strongly inhibit both true cholinesterase and pseudocholinesterase activities. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 56-70 9192209-1 1997 Organophosphate insecticides strongly inhibit both true cholinesterase and pseudocholinesterase activities. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 75-95 9305588-3 1997 The target of promotion is unknown, but it is likely to be different from neuropathy target esterase (NTE), the target of OPIDP, NTE is a neural phenyl valerate (PV) esterase, operationally defined by selective inhibition with organophosphates. Organophosphates 227-243 patatin like phospholipase domain containing 6 Gallus gallus 74-100 9305588-3 1997 The target of promotion is unknown, but it is likely to be different from neuropathy target esterase (NTE), the target of OPIDP, NTE is a neural phenyl valerate (PV) esterase, operationally defined by selective inhibition with organophosphates. Organophosphates 227-243 patatin like phospholipase domain containing 6 Gallus gallus 102-105 9305588-3 1997 The target of promotion is unknown, but it is likely to be different from neuropathy target esterase (NTE), the target of OPIDP, NTE is a neural phenyl valerate (PV) esterase, operationally defined by selective inhibition with organophosphates. Organophosphates 227-243 patatin like phospholipase domain containing 6 Gallus gallus 129-132 9299188-1 1997 Organophosphate (OP) pesticides can bind to carboxylesterase (CaE), which may lower the concentration of OPs at the target site enzyme, acetylcholinesterase (ChE). Organophosphates 0-15 acetylcholinesterase Rattus norvegicus 136-156 18966870-1 1997 A fibre-optic based on immobilized acetylcholinesterase is described and its application in the detection of carbamate and organophosphate pesticides through enzyme inhibition measurements is discussed. Organophosphates 123-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 20654312-1 1997 Organophosphate-induced delayed polyneuropathy (OPIDP) has been tested mainly byin vivo methods in the chicken and by examination of the inhibition of neuropathy target esterase in their neuronal tissue. Organophosphates 0-15 patatin like phospholipase domain containing 6 Gallus gallus 151-177 9324407-0 1997 [The presynaptic mechanism of interaction of cholinesterase reactivator and muscarinic antagonists in the animal"s defence in organophosphate intoxication]. Organophosphates 126-141 butyrylcholinesterase Rattus norvegicus 45-59 9113024-1 1997 Pesticide exposures cause disorders varying from straightforward topical irritant reactions, such as those to synthetic pyrethroid insecticides, to complex systemic illness, such as that resulting from cholinesterase inhibition by organophosphate pesticides. Organophosphates 231-246 butyrylcholinesterase Homo sapiens 202-216 9339222-15 1997 We concluded that brain SPECT is a highly sensitive diagnostic method, together with clinical symptoms and plasma cholinesterase activity, for monitoring the clinical prognosis of organophosphate poisonings. Organophosphates 180-195 butyrylcholinesterase Homo sapiens 114-128 9039856-1 1997 The most economical blood test for the monitoring of workers who are exposed to organophosphate pesticides is serum cholinesterase; however, serum cholinesterase can be affected by conditions other than pesticide exposure. Organophosphates 80-95 butyrylcholinesterase Homo sapiens 116-130 9429779-1 1997 Acetylcholinesterase (AChE) is the target site for the organophosphates and carbamates in insects. Organophosphates 55-71 neuroligin-4, Y-linked Musca domestica 0-20 9429779-1 1997 Acetylcholinesterase (AChE) is the target site for the organophosphates and carbamates in insects. Organophosphates 55-71 neuroligin-4, Y-linked Musca domestica 22-26 9051410-2 1997 Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Organophosphates 40-56 acetylcholinesterase Mus musculus 149-169 9471495-0 1997 [Possible consequences of AChE inhibition in organophosphate poisoning. Organophosphates 45-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9076564-5 1996 Based on our results and on the correlation reported in the literature between AChE reduction and muscarinic receptor density, the hazardous implications of organophosphate environmental contamination on human and animal health are pointed out. Organophosphates 157-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 9040125-1 1997 Chronic, low-level exposure to cholinesterase inhibitor organophosphate (OP) insecticides or chemical warfare agents produces abnormalities in CNS acetylcholine (ACh) function, and in humans, may be associated with impaired cognitive function as well after withdrawal from such exposure. Organophosphates 56-71 butyrylcholinesterase Homo sapiens 31-45 8951236-0 1996 Synthesis and 31P chemical shift identification of tripeptide active site models that represent human serum acetylcholinesterase covalently modified at serine by certain organophosphates. Organophosphates 170-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 8727218-2 1996 NTE has been proposed as a predictive marker in organophosphate poisoning for the subsequent development of organophosphate-induced delayed neuropathy. Organophosphates 48-63 patatin like phospholipase domain containing 6 Homo sapiens 0-3 8948071-0 1996 Bee head acetylcholinesterase as an indicator of exposure to organophosphate and carbamate insecticides. Organophosphates 61-76 acetylcholinesterase Apis mellifera 9-29 8948071-1 1996 Insect acetylcholinesterase has received special attention following the discovery that inhibition of the enzyme is the mechanism of activity of the organophosphate and carbamate insecticides. Organophosphates 149-164 acetylcholinesterase Apis mellifera 7-27 8727219-11 1996 Erythrocyte ChE activity was suppressed by every organophosphate. Organophosphates 49-64 butyrylcholinesterase Rattus norvegicus 12-15 9119338-3 1996 Data on the effects of halogenated hydrocarbons on the kidney, the effects of organic solvents on the central nervous system, and the effects of organophosphates on cholinesterase, are the basis of this assumption. Organophosphates 145-161 butyrylcholinesterase Homo sapiens 165-179 8921348-2 1996 This study was undertaken to ascertain whether other sulfonyl fluorides promote diisopropyl fluorophosphate (DFP) neuropathy in hens and if they inhibit neuropathy target esterase (NTE), the target for organophosphate-induced delayed polyneuropathy. Organophosphates 202-217 patatin like phospholipase domain containing 6 Gallus gallus 153-179 8921348-2 1996 This study was undertaken to ascertain whether other sulfonyl fluorides promote diisopropyl fluorophosphate (DFP) neuropathy in hens and if they inhibit neuropathy target esterase (NTE), the target for organophosphate-induced delayed polyneuropathy. Organophosphates 202-217 patatin like phospholipase domain containing 6 Gallus gallus 181-184 8937189-10 1996 In conclusion, protein mass determination of serum CHE provides valuable information concerning the target value of the serum CHE activity for the treatment of patients with organophosphate insecticide poisoning as well as for investigating the specific activity of genetic variants of serum CHE. Organophosphates 174-189 butyrylcholinesterase Homo sapiens 51-54 8937189-10 1996 In conclusion, protein mass determination of serum CHE provides valuable information concerning the target value of the serum CHE activity for the treatment of patients with organophosphate insecticide poisoning as well as for investigating the specific activity of genetic variants of serum CHE. Organophosphates 174-189 butyrylcholinesterase Homo sapiens 126-129 8937189-10 1996 In conclusion, protein mass determination of serum CHE provides valuable information concerning the target value of the serum CHE activity for the treatment of patients with organophosphate insecticide poisoning as well as for investigating the specific activity of genetic variants of serum CHE. Organophosphates 174-189 butyrylcholinesterase Homo sapiens 126-129 8694861-1 1996 Acute exposure to acetylcholinesterase (AChE) inhibitors such as organophosphates and carbamates induces functional changes at the neuromuscular junctions, leading to fasciculations that ultimately cause muscle fiber necrosis. Organophosphates 65-81 acetylcholinesterase Rattus norvegicus 18-38 8694861-1 1996 Acute exposure to acetylcholinesterase (AChE) inhibitors such as organophosphates and carbamates induces functional changes at the neuromuscular junctions, leading to fasciculations that ultimately cause muscle fiber necrosis. Organophosphates 65-81 acetylcholinesterase Rattus norvegicus 40-44 9000302-2 1996 AntiChEs consist of the organophosphates (OP), which irreversibly inhibit the enzyme acetylcholinesterase (AChE), and the carbamates (CB), which reversibly inhibit AChE. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 9000302-2 1996 AntiChEs consist of the organophosphates (OP), which irreversibly inhibit the enzyme acetylcholinesterase (AChE), and the carbamates (CB), which reversibly inhibit AChE. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 8727219-12 1996 This experiment demonstrated a correlation between the organophosphate suppression of serum ChE activity and the concentration of serum ChE isoenzyme band 6. Organophosphates 55-70 butyrylcholinesterase Rattus norvegicus 92-95 8727219-12 1996 This experiment demonstrated a correlation between the organophosphate suppression of serum ChE activity and the concentration of serum ChE isoenzyme band 6. Organophosphates 55-70 butyrylcholinesterase Rattus norvegicus 136-139 8727218-2 1996 NTE has been proposed as a predictive marker in organophosphate poisoning for the subsequent development of organophosphate-induced delayed neuropathy. Organophosphates 108-123 patatin like phospholipase domain containing 6 Homo sapiens 0-3 8727219-0 1996 Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat. Organophosphates 20-35 butyrylcholinesterase Rattus norvegicus 58-72 7657613-8 1995 Analysis of the kinetics of acylation by organophosphates and conjugation by trifluoroacetophenones, along with deconstruction of the kinetic constants for carboxyl esters, suggests that AChE inhibition by fasciculin arises from reductions of both the commitment to catalysis and diffusional entry of substrate into the gorge. Organophosphates 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 8661009-1 1996 A physiological role for paraoxonase (PON1) is still uncertain, but it catalyzes the hydrolysis of toxic organophosphates. Organophosphates 105-121 paraoxonase 1 Homo sapiens 38-42 9005355-5 1996 With this case report, we would first like to emphasize that MNS can evolve within a very short time into a severe and life-threatening situation requiring intensive medical care, and secondly to illustrate the implications of organophosphate poisoning and the consequent cholinesterase blocking far the differential diagnosis of MNS. Organophosphates 227-242 butyrylcholinesterase Homo sapiens 272-286 8724787-7 1996 At (4-6).10(-7) M aminostigmine prevents by 50% the irreversible binding of cholinesterase by certain organophosphate inhibitors of cholinesterase when the latter are used at concentrations needed to inhibit the enzymatic activity by 85-90%. Organophosphates 102-117 butyrylcholinesterase Homo sapiens 76-90 8724787-7 1996 At (4-6).10(-7) M aminostigmine prevents by 50% the irreversible binding of cholinesterase by certain organophosphate inhibitors of cholinesterase when the latter are used at concentrations needed to inhibit the enzymatic activity by 85-90%. Organophosphates 102-117 butyrylcholinesterase Homo sapiens 132-146 8900595-7 1996 It also shows that the closest relative of alpha E1 amongst previously published esterase sequences is ESTB1, which confers organophosphate resistance in Culex mosquitoes. Organophosphates 124-139 alpha-Esterase-1 Drosophila melanogaster 43-51 8664964-4 1996 Absorption of organophosphate pesticide was estimated before, immediately after, and six weeks after dipping by measuring plasma cholinesterase, erythrocyte cholinesterase, and dialkylphosphate urinary metabolites of organophosphates. Organophosphates 14-29 cholinesterase Ovis aries 129-143 8867149-6 1996 Our results indicated that the in vivo AChE inhibition test is selective, being very sensitive to detect toxicity of the organophosphates tested. Organophosphates 121-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 8783813-5 1996 The oximes significantly, but not completely, reactivated organophosphate inhibited AChE. Organophosphates 58-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 8783813-9 1996 These data suggest that 2-PAM HI 6 and HLo 7 are less patent than obidoxime in reactivating human AChE inhibited by organophosphate pesticides. Organophosphates 116-131 peptidylglycine alpha-amidating monooxygenase Homo sapiens 26-29 8783813-9 1996 These data suggest that 2-PAM HI 6 and HLo 7 are less patent than obidoxime in reactivating human AChE inhibited by organophosphate pesticides. Organophosphates 116-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23902326-7 1996 In both species, serum and whole blood were more sensitive than brain for revealing organophosphate-induced ChE inhibition and serum was more sensitive than whole blood. Organophosphates 84-99 butyrylcholinesterase Mus musculus 108-111 7758210-1 1995 We propose a novel and simple assay for the real-time differentiation between carbamate and organophosphate inhibition of cholinesterase, based on our observations of the kinetic behavior of inhibited enzyme. Organophosphates 92-107 butyrylcholinesterase Homo sapiens 122-136 8537325-1 1995 Organophosphate compounds are known to cause a selective increase of beta-glucuronidase activity in rat serum. Organophosphates 0-15 glucuronidase, beta Rattus norvegicus 69-87 8537325-2 1995 Previous data suggested that increase of serum beta-glucuronidase activity was well correlated with decrease of that activity in rat liver microsomal fraction, thereby, suggesting a role of the microsomal enzyme in mediating the organophosphate effect. Organophosphates 229-244 glucuronidase, beta Rattus norvegicus 47-65 8537326-1 1995 Organophosphate compounds are known to cause the selective release of rat liver microsomal beta-glucuronidase into plasma. Organophosphates 0-15 glucuronidase, beta Rattus norvegicus 91-109 8537326-2 1995 To investigate the alterations of molecular forms and oligosaccharide moieties of liver beta-glucuronidase in organophosphate compound-administered rats, beta-glucuronidase was isolated from microsomal, Golgi, lysosomal, and serum fractions. Organophosphates 110-125 glucuronidase, beta Rattus norvegicus 88-106 8537326-8 1995 These results imply that microsomal beta-glucuronidase undergoes extensive modification of the oligosaccharide moieties by terminal glycosyltransferases at the trans Golgi when it is destined for secretion into serum in response to treatment with an organophosphate compound. Organophosphates 250-265 glucuronidase, beta Rattus norvegicus 36-54 7664482-3 1995 Cholinesterase measurements are still used to monitor exposure to organophosphate insecticides and their clinical application requires a good understanding of the inter and intra-individual variation, as well as some knowledge of the time sequence between exposure and measurement of the cholinesterase activity. Organophosphates 66-81 butyrylcholinesterase Homo sapiens 0-14 7599168-2 1995 Using electron paramagnetic resonance (EPR) with spin-labelled organophosphate specifically bound to the AChE active-site serine, we studied the effects of both ligands on the topography of the AChE active-site gorge. Organophosphates 63-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 7766682-0 1995 Raman spectroscopic study of conjugates of butyrylcholinesterase with organophosphates. Organophosphates 70-86 butyrylcholinesterase Homo sapiens 43-64 7766682-6 1995 Considerable differences have been observed between native, paraoxon inhibited and "aged" BuChE in aromatic ring vibrations, suggesting that the dealkylation of organophosphate conjugates modifies the environment or the interactions of aromatic amino-acid residues. Organophosphates 161-176 butyrylcholinesterase Homo sapiens 90-95 7643964-0 1995 Effects of the organophosphate insecticide, monocrotophos, on acetylcholinesterase activity in the nile tilapia fish (Oreochromis niloticus) brain. Organophosphates 15-30 acetylcholinesterase Oreochromis niloticus 62-82 7671443-2 1995 Organophosphates can cause acute toxicity, which follows inhibition of acetylcholinesterase (AChE), or delayed neuropathy, which follows inhibition of neuropathy target esterase (NTE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 7671443-2 1995 Organophosphates can cause acute toxicity, which follows inhibition of acetylcholinesterase (AChE), or delayed neuropathy, which follows inhibition of neuropathy target esterase (NTE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 7671443-2 1995 Organophosphates can cause acute toxicity, which follows inhibition of acetylcholinesterase (AChE), or delayed neuropathy, which follows inhibition of neuropathy target esterase (NTE). Organophosphates 0-16 patatin like phospholipase domain containing 6 Homo sapiens 151-177 7671443-2 1995 Organophosphates can cause acute toxicity, which follows inhibition of acetylcholinesterase (AChE), or delayed neuropathy, which follows inhibition of neuropathy target esterase (NTE). Organophosphates 0-16 patatin like phospholipase domain containing 6 Homo sapiens 179-182 7671443-6 1995 Organophosphates actively able to inhibit AChE in animal models inhibited AChE in neuroblastoma cells. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 7671443-6 1995 Organophosphates actively able to inhibit AChE in animal models inhibited AChE in neuroblastoma cells. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 7671443-8 1995 Inhibition of NTE in neuroblastoma cells could identify active organophosphates capable of causing delayed neuropathy in animal models and distinguish these organophosphates from those that do not cause delayed neuropathy in animal models. Organophosphates 63-79 patatin like phospholipase domain containing 6 Homo sapiens 14-17 7671443-8 1995 Inhibition of NTE in neuroblastoma cells could identify active organophosphates capable of causing delayed neuropathy in animal models and distinguish these organophosphates from those that do not cause delayed neuropathy in animal models. Organophosphates 157-173 patatin like phospholipase domain containing 6 Homo sapiens 14-17 8583650-5 1995 Thermal reactivation of cholinesterase activity was used to correctly predict carbamates in 22 incidents and organophosphates in 59 incidents. Organophosphates 109-125 butyrylcholinesterase Homo sapiens 24-38 7820884-13 1995 These studies suggest that CYP2B1 metabolizes DFP and may significantly contribute to the detoxification of this organophosphate in vivo. Organophosphates 113-128 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 27-33 7482556-1 1995 Assessing the neurotoxic potential of organophosphate and carbamate pesticides should be greatly facilitated by the knowledge that the mechanism of action of these insecticides is presumed to be the inhibition of cholinesterase, the enzyme which controls the levels of neurotransmitter, acetycholine. Organophosphates 38-53 butyrylcholinesterase Homo sapiens 213-227 7476018-0 1995 Successive organophosphate inhibition and oxime reactivation reveals distinct responses of recombinant human cholinesterase variants. Organophosphates 11-26 butyrylcholinesterase Homo sapiens 109-123 7476018-9 1995 Individuals carrying the "atypical" BuChE allele may hence be unresponsive to oxime reactivation therapy following organophosphate poisoning. Organophosphates 115-130 butyrylcholinesterase Homo sapiens 36-41 7852061-1 1994 OBJECTIVE: To study the clinical profile and cholinesterase levels of subjects of organophosphate and carbamate poisoning and to identify those subjects who would require ventilatory support. Organophosphates 82-97 butyrylcholinesterase Homo sapiens 45-59 8523492-1 1995 The intermediate syndrome of organophosphate poisoning arises in the time interval between the acute cholinergic crisis of fasciculations and muscle weakness and the delayed neuropathy attributed to inhibition of the neuropathy target esterase. Organophosphates 29-44 patatin like phospholipase domain containing 6 Homo sapiens 217-243 7867909-1 1994 The effect of phosphotriesterase (PTE) on cholinesterase (ChE) activities was studied with exposures to different organophosphates in mice. Organophosphates 114-130 butyrylcholinesterase Mus musculus 58-61 7867909-12 1994 The results indicate that PTE pretreatment given iv prevents the inhibition of ChE activities after certain organophosphates and it also hastens the recovery of activities after PO poisoning. Organophosphates 108-124 butyrylcholinesterase Mus musculus 79-82 7974486-1 1994 Organophosphate-induced delayed polyneuropathy (OPIDP) is thought to be initiated by a variety of neuropathy target esterase (NTE) inhibitors. Organophosphates 0-15 patatin like phospholipase domain containing 6 Gallus gallus 98-124 7974486-1 1994 Organophosphate-induced delayed polyneuropathy (OPIDP) is thought to be initiated by a variety of neuropathy target esterase (NTE) inhibitors. Organophosphates 0-15 patatin like phospholipase domain containing 6 Gallus gallus 126-129 7988206-0 1994 Prognostic value of serum cholinesterase in organophosphate poisoning. Organophosphates 44-59 butyrylcholinesterase Homo sapiens 26-40 7853361-1 1994 A light addressable potentiometric sensor was used to measure acetylcholinesterase (AChE) activity in order to evaluate the protective effects of quaternary compounds and NaF against enzyme phosphorylation and aging by two organophosphates. Organophosphates 223-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 7853361-1 1994 A light addressable potentiometric sensor was used to measure acetylcholinesterase (AChE) activity in order to evaluate the protective effects of quaternary compounds and NaF against enzyme phosphorylation and aging by two organophosphates. Organophosphates 223-239 C-X-C motif chemokine ligand 8 Homo sapiens 171-174 7853361-2 1994 The use of the immobilized AChE made possible the quick removal of reagents (i.e., organophosphate, 2-pralidoxime, and protectant), thereby permitting accurate determination of AChE activity before and after phosphorylation and aging. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 7845858-0 1994 Prolongation of the prothrombin time after organophosphate poisoning. Organophosphates 43-58 coagulation factor II, thrombin Homo sapiens 20-31 7845858-1 1994 Prolongation of the prothrombin time owing to a transient reduction in factor VII activity is described in a 14-month-old child with organophosphate poisoning. Organophosphates 133-148 coagulation factor II, thrombin Homo sapiens 20-31 8023345-6 1994 We conclude that in addition to AChE, voltage-gated Ca2+ channels and nicotinic receptors are possible sites of action of organophosphates in mammalian systems. Organophosphates 122-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 7978137-3 1994 The onset of a paralytic ileus coincided with a spontaneous increase in red cell cholinesterase levels and may be an early sign of recovery from organophosphate poisoning. Organophosphates 145-160 butyrylcholinesterase Homo sapiens 81-95 8016090-2 1994 One mechanism of resistance is the alteration of acetylcholinesterase (EC 3.1.1.7), the molecular target for organophosphates and carbamates. Organophosphates 109-125 Acetylcholine esterase Drosophila melanogaster 49-69 7937562-1 1994 2,3-Butanedione monoxime, also known as diacetyl monoxime, is a nucleophilic agent which dephosphorylates acetylcholinesterase poisoned with organophosphates. Organophosphates 141-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 8035429-2 1994 The anti-HIV-1 activity of 11 analogues which included carboxylic ester or phosphoric ester linkages of PFA or PAA to BCH-189 was determined in MT-4 cells. Organophosphates 75-91 chimerin 2 Homo sapiens 118-121 7991223-5 1994 This study assesses the occurrence of the necrotizing myopathy in rats in relation to the clinical course and the acetylcholinesterase (AChE) inhibition after poisoning with organophosphates representative for each of the major types of organophosphate-related neurotoxicity. Organophosphates 174-190 acetylcholinesterase Rattus norvegicus 114-134 7991223-5 1994 This study assesses the occurrence of the necrotizing myopathy in rats in relation to the clinical course and the acetylcholinesterase (AChE) inhibition after poisoning with organophosphates representative for each of the major types of organophosphate-related neurotoxicity. Organophosphates 174-190 acetylcholinesterase Rattus norvegicus 136-140 7991223-5 1994 This study assesses the occurrence of the necrotizing myopathy in rats in relation to the clinical course and the acetylcholinesterase (AChE) inhibition after poisoning with organophosphates representative for each of the major types of organophosphate-related neurotoxicity. Organophosphates 174-189 acetylcholinesterase Rattus norvegicus 114-134 7991223-5 1994 This study assesses the occurrence of the necrotizing myopathy in rats in relation to the clinical course and the acetylcholinesterase (AChE) inhibition after poisoning with organophosphates representative for each of the major types of organophosphate-related neurotoxicity. Organophosphates 174-189 acetylcholinesterase Rattus norvegicus 136-140 7991223-7 1994 The necrotizing myopathy begins shortly after the initial decline in AChE activity with all organophosphates studied. Organophosphates 92-108 acetylcholinesterase Rattus norvegicus 69-73 8023345-2 1994 However, subacute exposure of humans to organophosphates induces cognitive and emotional defects which might not solely be attributable to AChE inhibition. Organophosphates 40-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 8068758-10 1994 Therefore, blood from normal or organophosphate-treated horses can be used for cholinesterase evaluation for up to 1 week when stored at 5 C. Organophosphates 32-47 butyrylcholinesterase Equus caballus 79-93 8186246-6 1994 Such potent and synergistic inhibition of AChE suggest that TS or CS, alone and in combination with THA, may prove beneficial in the treatment of organophosphate poisoning and Alzheimer"s disease. Organophosphates 146-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 7935148-1 1994 Blood cholinesterase activity is an efficient indicator of exposure to organophosphate insecticides. Organophosphates 71-86 butyrylcholinesterase Homo sapiens 6-20 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). Organophosphates 189-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 7911348-7 1994 The pto mutants retain sensitivity to the organophosphate insecticide fenthion; this trait segregates with Pto in genetic crosses. Organophosphates 42-57 serine/threonine protein kinase Pto Solanum lycopersicum 4-7 8031294-1 1994 We identify an esterase isozyme in Drosophila melanogaster, EST 23, which shares biochemical, physiological, and genetic properties with esterase E3, which is involved in resistance to organophosphate insecticides in Lucilia cuprina. Organophosphates 185-200 alpha-Esterase-7 Drosophila melanogaster 60-66 8129072-1 1994 A semiquantitative tintometric field kit has been used in the developing world for almost 30 years to measure whole blood cholinesterase levels in persons exposed to organophosphate pesticides. Organophosphates 166-181 butyrylcholinesterase Homo sapiens 122-136 8264551-0 1993 Monoclonal antibody AE-2 modulates carbamate and organophosphate inhibition of fetal bovine serum acetylcholinesterase. Organophosphates 49-64 solute carrier family 4 member 2 Homo sapiens 20-24 8304979-1 1994 Pretreatment of rhesus monkeys with fetal bovine serum acetylcholinesterase (FBS AChE) provides complete protection against 5 LD50 of organophosphate (OP) without any signs of toxicity or performance decrements as measured by serial probe recognition tests or primate equilibrium platform performance (Maxwell et al., Toxicol Appl Pharmacol 115: 44-49, 1992; Wolfe et al., Toxicol Appl Pharmacol 117: 189-193, 1992). Organophosphates 134-149 acetylcholinesterase Mus musculus 55-75 8304979-1 1994 Pretreatment of rhesus monkeys with fetal bovine serum acetylcholinesterase (FBS AChE) provides complete protection against 5 LD50 of organophosphate (OP) without any signs of toxicity or performance decrements as measured by serial probe recognition tests or primate equilibrium platform performance (Maxwell et al., Toxicol Appl Pharmacol 115: 44-49, 1992; Wolfe et al., Toxicol Appl Pharmacol 117: 189-193, 1992). Organophosphates 134-149 acetylcholinesterase Macaca mulatta 81-85 7979963-9 1994 By comparison, a non-neurotoxic organophosphate, ecothiopate (0.5 mumol/kg), was a potent inhibitor of diaphragm acetylcholinesterase and produced a large increase in postjunctional jitter but ecothiopate did not inhibit brain neuropathy target esterase and had no effect on prejunctional jitter. Organophosphates 32-47 acetylcholinesterase Mus musculus 113-133 7979963-9 1994 By comparison, a non-neurotoxic organophosphate, ecothiopate (0.5 mumol/kg), was a potent inhibitor of diaphragm acetylcholinesterase and produced a large increase in postjunctional jitter but ecothiopate did not inhibit brain neuropathy target esterase and had no effect on prejunctional jitter. Organophosphates 32-47 patatin-like phospholipase domain containing 6 Mus musculus 227-253 7979963-10 1994 Doses were chosen so that the inhibition of diaphragm acetylcholinesterase by each of the two organophosphates was similar. Organophosphates 94-110 acetylcholinesterase Mus musculus 54-74 7708361-1 1994 This mini-review mainly describes a part of the pharmacological research carried out in our laboratory during the past decades, aimed at finding a therapy against intoxication by cholinesterase-inhibiting organophosphates, in particular against the nerve agent soman. Organophosphates 205-221 butyrylcholinesterase Homo sapiens 179-193 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Organophosphates 268-284 solute carrier family 4 member 2 Homo sapiens 26-30 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Organophosphates 268-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 8191502-4 1993 However, all known promoters are also inhibitors of neuropathy target esterase (NTE), the putative target of organophosphate neuropathy, but it has been shown that the target of promotion is unlikely to be NTE. Organophosphates 109-124 patatin like phospholipase domain containing 6 Homo sapiens 52-78 8107298-3 1993 We determined the activity and isoenzyme patterns of serum cholinesterase (ChE) obtained from 13 human patients who attempted suicide with various organophosphates, i.e. Fenitrothion, Malathion, Isoxathion, Pyridaphenthion and Trichlorfon, and studied on the changes in the activity and isoenzyme patterns of serum ChE after ingestion. Organophosphates 147-163 butyrylcholinesterase Homo sapiens 75-78 8107298-16 1993 These findings demonstrated the changes in the activity and isoenzyme pattern of serum ChE in patients poisoned with several organophosphates after PAM and HP-HD treatment. Organophosphates 125-141 butyrylcholinesterase Homo sapiens 87-90 8107298-3 1993 We determined the activity and isoenzyme patterns of serum cholinesterase (ChE) obtained from 13 human patients who attempted suicide with various organophosphates, i.e. Fenitrothion, Malathion, Isoxathion, Pyridaphenthion and Trichlorfon, and studied on the changes in the activity and isoenzyme patterns of serum ChE after ingestion. Organophosphates 147-163 butyrylcholinesterase Homo sapiens 59-73 8191502-4 1993 However, all known promoters are also inhibitors of neuropathy target esterase (NTE), the putative target of organophosphate neuropathy, but it has been shown that the target of promotion is unlikely to be NTE. Organophosphates 109-124 patatin like phospholipase domain containing 6 Homo sapiens 80-83 8343992-1 1993 Neuropathy target esterase (NTE) is a membrane-bound protein which has been proposed as the target site in nerve tissue for initiation of organophosphate induced delayed neuropathy (OPIDN). Organophosphates 138-153 patatin like phospholipase domain containing 6 Gallus gallus 0-26 8211998-3 1993 When neuropathic organophosphates modify more than 70% of NTE in this way, neuropathy develops 2 weeks later. Organophosphates 17-33 patatin like phospholipase domain containing 6 Homo sapiens 58-61 8343979-0 1993 Drosophila acetylcholinesterase: mechanisms of resistance to organophosphates. Organophosphates 61-77 Acetylcholine esterase Drosophila melanogaster 11-31 7693961-0 1993 Serum paraoxonase status: a major factor in determining resistance to organophosphates. Organophosphates 70-86 serum paraoxonase/arylesterase 1 Oryctolagus cuniculus 0-17 8215602-0 1993 Effect of exposure to organophosphate pesticides on serum cholinesterase levels. Organophosphates 22-37 butyrylcholinesterase Homo sapiens 58-72 8355009-0 1993 Cholinesterase activity in postmortem blood as a screening test for organophosphate/chemical weapon exposure. Organophosphates 68-83 butyrylcholinesterase Homo sapiens 0-14 8328984-2 1993 Butyrylcholinesterase purified from human plasma (HuBChE) was evaluated both in vitro and in vivo in mice and rats as a single prophylactic antidote against the lethal effects of highly toxic organophosphates (OP). Organophosphates 192-208 butyrylcholinesterase Homo sapiens 0-21 8344001-1 1993 To initiate delayed neuropathy (DN) in adult hens organophosphates and phosphonates must inhibit most neural NTE and the inhibited NTE must undergo an "aging" reaction. Organophosphates 50-66 patatin like phospholipase domain containing 6 Gallus gallus 109-112 8343979-4 1993 An overproduction of acetylcholinesterase outside the central nervous system also protects against organophosphate poisoning, that is, flies producing a soluble acetylcholinesterase, secreted in the haemolymph, are resistant to organophosphates. Organophosphates 99-114 Acetylcholine esterase Drosophila melanogaster 21-41 8343979-4 1993 An overproduction of acetylcholinesterase outside the central nervous system also protects against organophosphate poisoning, that is, flies producing a soluble acetylcholinesterase, secreted in the haemolymph, are resistant to organophosphates. Organophosphates 99-114 Acetylcholine esterase Drosophila melanogaster 161-181 8343992-1 1993 Neuropathy target esterase (NTE) is a membrane-bound protein which has been proposed as the target site in nerve tissue for initiation of organophosphate induced delayed neuropathy (OPIDN). Organophosphates 138-153 patatin like phospholipase domain containing 6 Gallus gallus 28-31 8343979-4 1993 An overproduction of acetylcholinesterase outside the central nervous system also protects against organophosphate poisoning, that is, flies producing a soluble acetylcholinesterase, secreted in the haemolymph, are resistant to organophosphates. Organophosphates 228-244 Acetylcholine esterase Drosophila melanogaster 21-41 8343979-4 1993 An overproduction of acetylcholinesterase outside the central nervous system also protects against organophosphate poisoning, that is, flies producing a soluble acetylcholinesterase, secreted in the haemolymph, are resistant to organophosphates. Organophosphates 228-244 Acetylcholine esterase Drosophila melanogaster 161-181 8343996-2 1993 It has been known for over twenty years that non-neuropathic inhibitors of NTE exist and can actually prevent OPIDN when given before a neuropathic organophosphate (OP). Organophosphates 148-163 patatin like phospholipase domain containing 6 Gallus gallus 75-78 8343986-7 1993 Use of acetylcholinesterase as a single pretreatment drug provided greater protection against both lethal and behavioral effects of potent organophosphates than current multicomponent drug treatments that prevent neither signs of toxicity nor behavioral deficits. Organophosphates 139-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 8343986-12 1993 Pretreatment of mice with fetal bovine serum acetylcholinesterase and HI-6 amplified the effectiveness of exogenous enzyme as a scavenger for organophosphate. Organophosphates 142-157 acetylcholinesterase Mus musculus 45-65 8343991-3 1993 Studies with many organophosphates, phosphinates and chiral phosphonates are entirely consistent with a 2-step process of initiation referred to as "NTE (70-80%) aging": about 70-80% of available nervous system NTE is first covalently phosphylated causing inhibition of esterase activity, and then the molecules of inhibited NTE undergo a covalent bond-cleavage leaving a negative charge in the region of the still-bound phosphorus. Organophosphates 18-34 patatin like phospholipase domain containing 6 Gallus gallus 149-152 8393746-1 1993 Neuropathy target esterase (NTE) was identified as the molecular target for organophosphate-induced delayed polyneuropathy several years ago but its physiological functions are still unknown. Organophosphates 76-91 patatin like phospholipase domain containing 6 Homo sapiens 0-26 8393746-1 1993 Neuropathy target esterase (NTE) was identified as the molecular target for organophosphate-induced delayed polyneuropathy several years ago but its physiological functions are still unknown. Organophosphates 76-91 patatin like phospholipase domain containing 6 Homo sapiens 28-31 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphates 4-20 patatin like phospholipase domain containing 6 Homo sapiens 132-158 8503347-5 1993 Organophosphate pesticides act as irreversible acetylcholinesterase inhibitors, while carbamate pesticides produce reversible effects. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 8349949-0 1993 Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl. Organophosphates 97-112 interleukin 2 Mus musculus 14-27 8349949-4 1993 In the present study, we examined the potential of 8 antiCHE insecticides (4 carbamates and 4 organophosphates) to inhibit IL2-dependent proliferation of mouse CTLL2 cells. Organophosphates 94-110 interleukin 2 Mus musculus 123-126 8115829-3 1993 Organophosphate intoxication in agricultural workers was also assessed by measuring concentrations of seric cholinesterase. Organophosphates 0-15 butyrylcholinesterase Homo sapiens 108-122 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphates 4-20 patatin like phospholipase domain containing 6 Homo sapiens 160-163 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphates 4-20 patatin like phospholipase domain containing 6 Homo sapiens 196-199 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphates 4-20 patatin like phospholipase domain containing 6 Homo sapiens 196-199 8470119-4 1993 Our initial results show statistically significant exposure-related decreases in either red cell (AChE) or plasma cholinesterase activity ((butyrl)cholinesterase; BuChE) occurred not only among pesticide appliers who use organophosphates, but also among appliers of the fumigant phosphine. Organophosphates 221-237 butyrylcholinesterase Homo sapiens 114-128 8470119-4 1993 Our initial results show statistically significant exposure-related decreases in either red cell (AChE) or plasma cholinesterase activity ((butyrl)cholinesterase; BuChE) occurred not only among pesticide appliers who use organophosphates, but also among appliers of the fumigant phosphine. Organophosphates 221-237 butyrylcholinesterase Homo sapiens 147-161 8435096-10 1993 The results demonstrate that reversible inhibition of AChE with suppression of acetylcholine synthesis into a single compound, CAB, enhances the protection against organophosphates. Organophosphates 164-180 acetylcholinesterase Cavia porcellus 54-58 8453476-2 1993 A massive and transitory increase in c-fos mRNA and Fos protein occurred in rats intoxicated by a single dose of soman (organophosphate compound and irreversible cholinesterase inhibitor) only in animals that had seizures. Organophosphates 120-135 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 37-42 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 128-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8250487-0 1993 [Aging of cholinesterase after inhibition by organophosphates]. Organophosphates 45-61 butyrylcholinesterase Homo sapiens 10-24 8481105-0 1993 Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate. Organophosphates 154-169 butyrylcholinesterase Homo sapiens 0-14 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 128-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 8098250-1 1993 The organophosphate cholinesterase inhibitor paraoxon is hydrolysed by serum paraoxonase/arylesterase. Organophosphates 4-19 butyrylcholinesterase Homo sapiens 20-34 7984815-0 1993 [A biochemical method for the determination of the altered acetylcholinesterase which confers resistance to organophosphate and carbamate insecticides in Culex quinquefasciatus Say, 1823]. Organophosphates 108-123 acetylcholinesterase Culex quinquefasciatus 59-79 8459784-1 1993 Risk assessment of the neurotoxicology of organophosphate (OP) pesticides calls for a thorough understanding of the relationship between tissue cholinesterase (ChE) activity and changes in behavioral and autonomic responses to OP treatment. Organophosphates 42-57 butyrylcholinesterase Rattus norvegicus 144-158 8459784-1 1993 Risk assessment of the neurotoxicology of organophosphate (OP) pesticides calls for a thorough understanding of the relationship between tissue cholinesterase (ChE) activity and changes in behavioral and autonomic responses to OP treatment. Organophosphates 42-57 butyrylcholinesterase Rattus norvegicus 160-163 7984815-1 1993 The application of a rapid technique to determine the frequency of the altered acetylcholinesterase gene which confers cross resistance to organophosphate and carbamate insecticides to mosquitoes, was tested. Organophosphates 139-154 acetylcholinesterase Culex quinquefasciatus 79-99 8493783-3 1993 Also, there have been no significant differences in efficacy and speed of reactivation of acetylcholinesterase inhibited by organophosphates when HI-6 is applied in the form of permanent intravenous infusion or repeated intramuscular injections. Organophosphates 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 1280867-1 1992 The capacity of an organophosphate to elicit the acute phase response (APR) was assessed by studying the effects of acute soman intoxication on two major processes which characterize inflammation, cytokine production in macrophages and the expression of acute phase protein (APP) genes in the liver. Organophosphates 19-34 amyloid beta precursor protein Rattus norvegicus 254-273 1438284-6 1992 The mutated enzyme was also inhibited well by the bulky, BtChoEase-selective organophosphate inhibitor (tetraisopropylpyrophosphoramide, iso-OMPA). Organophosphates 77-92 butyrylcholinesterase Homo sapiens 57-66 1445194-1 1992 A carboxylesterase (EC 3.1.1.1) involved in organophosphate insecticide resistance has been purified and characterized from the mosquito Culex quinquefasciatus. Organophosphates 44-59 esterase 6 Culex quinquefasciatus 2-18 1331918-0 1992 Organophosphate-induced alterations in muscarinic receptor binding and phosphoinositide hydrolysis in the human SK-N-SH cell line. Organophosphates 0-15 hedgehog acyltransferase Homo sapiens 112-116 1399773-0 1992 Characterizing biological variability in livestock blood cholinesterase activity for biomonitoring organophosphate nerve agent exposure. Organophosphates 99-114 cholinesterase Ovis aries 57-71 1417899-1 1992 During the development of behavioral tolerance to the organophosphate monocrotophos, the activities of AChE and BuChE and the content of ACh were affected in different brain areas of male albino rats. Organophosphates 54-69 acetylcholinesterase Rattus norvegicus 103-107 1637204-9 1992 The experimental results indicate that the nondestructive biomarker BChE can give an early qualitative and semi-quantitative warning of the toxic effects of organophosphate and carbamate insecticides in birds. Organophosphates 157-172 cholinesterase Coturnix japonica 68-72 1631892-4 1992 Both in vitro and in vivo titration of FBS AChE with soman produced a 1:1 stoichiometry between organophosphate-inhibited FBS AChE and the cumulative dose of the toxic stereoisomers of soman. Organophosphates 96-111 acetylcholinesterase Macaca mulatta 43-47 1502984-0 1992 [Dynamic changes in the organophosphate metabolites of the lenses affected by endotoxin and S-antigen induced uveitis]. Organophosphates 24-39 S-antigen visual arrestin Rattus norvegicus 92-101 1631892-4 1992 Both in vitro and in vivo titration of FBS AChE with soman produced a 1:1 stoichiometry between organophosphate-inhibited FBS AChE and the cumulative dose of the toxic stereoisomers of soman. Organophosphates 96-111 acetylcholinesterase Macaca mulatta 126-130 1631892-5 1992 Administration of FBS AChE protected monkeys against the lethal effects of up to 2.7 LD50 of soman and prevented any signs of organophosphate intoxication, e.g., excessive secretions, respiratory depression, muscle fasciculations, or convulsions. Organophosphates 126-141 acetylcholinesterase Macaca mulatta 22-26 1346558-1 1992 In the last decade, pyridostigmine, a quaternary carbamate that reversibly inhibits the enzyme acetylcholinesterase, was proposed for pretreatment of nerve gas (organophosphate) poisoning. Organophosphates 161-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 1375016-2 1992 The organophosphate poisoning was always indicated by a significant depression of serum and/or red blood cell cholinesterase activities. Organophosphates 4-19 butyrylcholinesterase Homo sapiens 110-124 1539077-1 1992 Pyridostigmine bromide (Pyr), a reversible cholinesterase inhibitor, is currently suggested to be the most effective pretreatment drug against intoxication with potent organophosphates (OP). Organophosphates 168-184 butyrylcholinesterase Rattus norvegicus 43-57 1324821-4 1992 Organophosphate-induced delayed neuropathy (OPIDN) arises 1-3 weeks after exposure to some OP compounds all capable of remarkably inhibiting a distinct esterase called neuropathy target esterase (NTE) during a critical time period. Organophosphates 0-15 patatin like phospholipase domain containing 6 Homo sapiens 168-194 1324821-4 1992 Organophosphate-induced delayed neuropathy (OPIDN) arises 1-3 weeks after exposure to some OP compounds all capable of remarkably inhibiting a distinct esterase called neuropathy target esterase (NTE) during a critical time period. Organophosphates 0-15 patatin like phospholipase domain containing 6 Homo sapiens 196-199 1482283-6 1992 HLo 7 was very efficient in reactivating acetylcholinesterase (AChE) blocked by organophosphates as long as ageing did not prevent dephosphylation. Organophosphates 80-96 acetylcholinesterase Mus musculus 41-61 1482283-6 1992 HLo 7 was very efficient in reactivating acetylcholinesterase (AChE) blocked by organophosphates as long as ageing did not prevent dephosphylation. Organophosphates 80-96 acetylcholinesterase Mus musculus 63-67 1552378-0 1992 Monitoring organophosphate insecticide-exposed workers for cholinesterase depression. Organophosphates 11-26 butyrylcholinesterase Homo sapiens 59-73 1552378-2 1992 A serious limitation to the diagnosis of mild organophosphate poisoning and to the preventive screening of organophosphate-exposed workers has been the large interindividual variability in erythrocyte cholinesterase. Organophosphates 107-122 butyrylcholinesterase Homo sapiens 201-215 1664331-1 1991 Experiments were performed to elucidate the mechanism of action by which the oxime HI-6 causes a recovery of neuromuscular function after oxime-resistant inhibition of acetylcholinesterase by the organophosphate S27. Organophosphates 196-211 acetylcholinesterase Rattus norvegicus 168-188 1410689-6 1992 Useful adjuncts to ChE measurements are oxime reactivation tests and assay of neuropathy target esterase, an enzyme associated with organophosphate-induced delayed neuropathy. Organophosphates 132-147 patatin like phospholipase domain containing 6 Homo sapiens 78-104 1375401-0 1992 Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures. Organophosphates 106-121 butyrylcholinesterase Rattus norvegicus 44-58 1755022-1 1991 This study examined the relationship between inhibition of cholinesterase activity (CA) and thermoregulatory response in the rat following exposure to the organophosphate (OP), diisopropyl fluorophosphate (DFP). Organophosphates 155-170 butyrylcholinesterase Rattus norvegicus 59-73 1757241-1 1991 Pyridostigmine bromide, a reversible inhibitor of acetylcholinesterase (AChE), is effectively used as a pre-treatment to organophosphate intoxication. Organophosphates 121-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 1885319-0 1991 Cholinesterase activity in domestic animals as a potential biomonitor for nerve agent and other organophosphate exposure. Organophosphates 96-111 butyrylcholinesterase Homo sapiens 0-14 1906943-5 1991 In general, organophosphates are more neurotoxic than carbamate compounds, as evidenced by higher degree of AChE inhibition by DFP and Metacid-50 as compared to eserine and carbaryl. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 1906943-6 1991 Assays were also done with psychotropic drugs by employing the procedure of in vitro AChE inhibition kinetics, and it was found that psychotropic drugs are less potent than organophosphate and carbamate compounds. Organophosphates 173-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 1906943-7 1991 Results indicate that pure and commercial organophosphates and carbamates and psychotropic drugs are all able to significantly alter the AChE activity. Organophosphates 42-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 2062307-2 1991 A cDNA lambda gt11 library was prepared from the organophosphate insecticide-resistant housefly strain Cornell-R--a variant that has elevated GST activity. Organophosphates 49-64 glutathione S-transferase Musca domestica 142-145 2052184-1 1991 We have successfully demonstrated that exogenously administered acetyl- or butyrylcholinesterase (AChE, BChE respectively) will sequester organophosphates (OPs) before they reach their physiological targets. Organophosphates 138-154 butyrylcholinesterase Homo sapiens 104-108 1920540-0 1991 Release of liver microsomal beta-glucuronidase from hepatocytes in vitro and in vivo by organophosphates and hepatotoxic agents. Organophosphates 88-104 glucuronidase beta Homo sapiens 28-46 1920540-4 1991 Dissociation of the egasyn-beta-glucuronidase complex in vivo by organophosphates was followed by massive and rapid secretion of microsomal beta-glucuronidase into plasma. Organophosphates 65-81 carboxylesterase 1 Homo sapiens 20-26 1647337-1 1991 Pyridostigmine has a protective effect against organophosphate poisoning when given in a dosage of 30 mg three times daily causing 20-40% cholinesterase inhibition. Organophosphates 47-62 butyrylcholinesterase Homo sapiens 138-152 1920540-4 1991 Dissociation of the egasyn-beta-glucuronidase complex in vivo by organophosphates was followed by massive and rapid secretion of microsomal beta-glucuronidase into plasma. Organophosphates 65-81 glucuronidase beta Homo sapiens 27-45 2247789-1 1990 Serum cholinesterase (CHE) activity falls dramatically with organophosphate poisoning. Organophosphates 60-75 butyrylcholinesterase Homo sapiens 6-20 1985645-2 1991 A markedly suppressed level of pseudocholinesterase and red blood cell cholinesterase with profuse salivation and sweating confirmed the diagnosis of organophosphate poisoning. Organophosphates 150-165 butyrylcholinesterase Homo sapiens 31-51 1985645-2 1991 A markedly suppressed level of pseudocholinesterase and red blood cell cholinesterase with profuse salivation and sweating confirmed the diagnosis of organophosphate poisoning. Organophosphates 150-165 butyrylcholinesterase Homo sapiens 37-51 2005669-1 1991 Although acetylcholinesterase is the target molecule of organophosphate poisoning, it is not always assayed in clinical evaluations which include only the determination of plasma or serum cholinesterase. Organophosphates 56-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 2005669-1 1991 Although acetylcholinesterase is the target molecule of organophosphate poisoning, it is not always assayed in clinical evaluations which include only the determination of plasma or serum cholinesterase. Organophosphates 56-71 butyrylcholinesterase Homo sapiens 15-29 2005669-9 1991 The determination of both cholinesterase and acetylcholinesterase assists the evaluation of individuals exposed to or poisoned by organophosphate, the differentiation of other conditions affecting cholinesterase and the recognition of genetically atypical cholinesterase. Organophosphates 130-145 butyrylcholinesterase Homo sapiens 26-40 2005669-9 1991 The determination of both cholinesterase and acetylcholinesterase assists the evaluation of individuals exposed to or poisoned by organophosphate, the differentiation of other conditions affecting cholinesterase and the recognition of genetically atypical cholinesterase. Organophosphates 130-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 2005669-9 1991 The determination of both cholinesterase and acetylcholinesterase assists the evaluation of individuals exposed to or poisoned by organophosphate, the differentiation of other conditions affecting cholinesterase and the recognition of genetically atypical cholinesterase. Organophosphates 130-145 butyrylcholinesterase Homo sapiens 51-65 2005669-9 1991 The determination of both cholinesterase and acetylcholinesterase assists the evaluation of individuals exposed to or poisoned by organophosphate, the differentiation of other conditions affecting cholinesterase and the recognition of genetically atypical cholinesterase. Organophosphates 130-145 butyrylcholinesterase Homo sapiens 51-65 1768852-1 1991 The present study was undertaken to evaluate the neurotoxic effects of the organophosphate, phosphamidon, on glutathione-S-transferase (GST) activity and concentration of sulphhydryl groups, and to study the possible protection against these effects by the simultaneous administration of the antioxidant, acetylhomocysteine thiolactone, commonly known as citiolone. Organophosphates 75-90 hematopoietic prostaglandin D synthase Rattus norvegicus 109-134 1768852-1 1991 The present study was undertaken to evaluate the neurotoxic effects of the organophosphate, phosphamidon, on glutathione-S-transferase (GST) activity and concentration of sulphhydryl groups, and to study the possible protection against these effects by the simultaneous administration of the antioxidant, acetylhomocysteine thiolactone, commonly known as citiolone. Organophosphates 75-90 hematopoietic prostaglandin D synthase Rattus norvegicus 136-139 1987659-0 1991 The synergism of atropine and the cholinesterase reactivator HI-6 in counteracting lethality by organophosphate intoxication in the rat. Organophosphates 96-111 butyrylcholinesterase Rattus norvegicus 34-48 2260984-1 1990 Neuropathy target esterase (NTE) is a membrane-bound carboxylesterase activity which is proposed as the target site in nerve tissue for initiation of organophosphate-induced delayed neuropathy. Organophosphates 150-165 patatin like phospholipase domain containing 6 Gallus gallus 0-26 2260984-1 1990 Neuropathy target esterase (NTE) is a membrane-bound carboxylesterase activity which is proposed as the target site in nerve tissue for initiation of organophosphate-induced delayed neuropathy. Organophosphates 150-165 patatin like phospholipase domain containing 6 Gallus gallus 28-31 2247789-1 1990 Serum cholinesterase (CHE) activity falls dramatically with organophosphate poisoning. Organophosphates 60-75 butyrylcholinesterase Homo sapiens 22-25 2247790-0 1990 Low serum cholinesterase levels in rural workers exposed to organophosphate pesticide sprays. Organophosphates 60-75 butyrylcholinesterase Homo sapiens 10-24 2242023-0 1990 Multiple molecular forms and lectin interactions of organophosphate-sensitive plasma and liver esterases during development of the chick. Organophosphates 52-67 galectin 3 Gallus gallus 29-35 2208120-5 1990 However, significantly elevated risks for leukemia of greater than or equal to 2.0 were seen for exposure to specific animal insecticides including the organophosphates crotoxyphos (OR 11.1), dichlorvos (OR 2.0), and famphur (OR 2.2) and the natural product pyrethrins (OR 3.7) and the chlorinated hydrocarbon methoxychlor (OR 2.2). Organophosphates 152-168 olfactory receptor family 5 subfamily H member 8 (gene/pseudogene) Homo sapiens 270-276 2096825-0 1990 [Formation of models of the interaction between organophosphate compound structure and their ability to inhibit cholinesterase]. Organophosphates 48-63 butyrylcholinesterase Homo sapiens 112-127 2256118-25 1990 The approach holds promise for predictive simulation of organophosphate-mediated AChE inhibition in humans. Organophosphates 56-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 2238437-4 1990 The organophosphate compound (OP) induced an initial reduction in the activity of NTE, TE and AchE which was reestablished 48 h later, except for brain TE which increased slowly during the latency period. Organophosphates 4-19 patatin like phospholipase domain containing 6 Gallus gallus 82-85 2258509-1 1990 Amplification of the esterase B1 gene of Culex quinquefasciatus Say results in high titers of an esterase enzyme that confers resistance to organophosphate insecticides. Organophosphates 140-155 esterase B1 Culex quinquefasciatus 21-32 2132992-5 1990 There was a significant increase in the amount of Cytochrome P450 in Cx quinquefasciatus lines selected with the pyrethroid permethrin or with the organophosphate pirimiphos-methyl, but no change in lines selected with five other organophosphates or propoxur, compared to the parental strain, which suggests that oxidases are involved in the P450 mediated resistance to both permethrin and pirimiphos-methyl. Organophosphates 147-162 probable cytochrome P450 313a4 Culex quinquefasciatus 50-65 2242183-2 1990 The endogenous accumulation of acetylcholine results--as in the acute pancreatitis caused by poisoning with organophosphates--in massive hyperemia and an increased secretory activity with leakage of saliva into the tissue, in an activation of the kallikrein-kinin system, the phospholipase A2, and, ultimately, in toxic tissue lesions caused by lysolecithin and the superoxide-radical anion. Organophosphates 108-124 phospholipase A2 group IB Homo sapiens 276-292 2400840-0 1990 In vitro inhibition of acetylcholinesterase from four marine species by organophosphates and carbamates. Organophosphates 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 2226766-0 1990 [The effect of a fluorocarbon emulsion--an enzyme inducer of the cytochrome P-450-dependent monooxygenase system of the liver--on the acute toxicity of CCl4 and on the efficacy of the prophylactic use of antidotes in organophosphate pesticide poisoning]. Organophosphates 217-232 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 65-81 2132992-5 1990 There was a significant increase in the amount of Cytochrome P450 in Cx quinquefasciatus lines selected with the pyrethroid permethrin or with the organophosphate pirimiphos-methyl, but no change in lines selected with five other organophosphates or propoxur, compared to the parental strain, which suggests that oxidases are involved in the P450 mediated resistance to both permethrin and pirimiphos-methyl. Organophosphates 230-246 probable cytochrome P450 313a4 Culex quinquefasciatus 50-65 2363176-8 1990 The kinetic data suggest that trout brain AChE not only possesses less steric tolerance, but also has a weaker nucleophile at the esteratic subsite, both of which may be important factors in conferring the observed insensitivity of trout to acute organophosphate intoxication. Organophosphates 247-262 acetylcholinesterase Rattus norvegicus 42-46 2395814-5 1990 In the doses used, both organophosphates inhibited acetylcholinesterase (AChE) activity significantly in the blood. Organophosphates 24-40 acetylcholinesterase Rattus norvegicus 51-71 2395814-5 1990 In the doses used, both organophosphates inhibited acetylcholinesterase (AChE) activity significantly in the blood. Organophosphates 24-40 acetylcholinesterase Rattus norvegicus 73-77 2339415-2 1990 Acetylcholinesterase is the target enzyme for organophosphate toxicity while aliesterases are alternative targets for organophosphate inhibition which could serve in a protective capacity during organophosphate intoxication. Organophosphates 46-61 acetylcholinesterase Rattus norvegicus 0-20 2339415-2 1990 Acetylcholinesterase is the target enzyme for organophosphate toxicity while aliesterases are alternative targets for organophosphate inhibition which could serve in a protective capacity during organophosphate intoxication. Organophosphates 118-133 acetylcholinesterase Rattus norvegicus 0-20 2339415-2 1990 Acetylcholinesterase is the target enzyme for organophosphate toxicity while aliesterases are alternative targets for organophosphate inhibition which could serve in a protective capacity during organophosphate intoxication. Organophosphates 118-133 acetylcholinesterase Rattus norvegicus 0-20 1690462-9 1990 Rats pretreated with paraoxonase exhibited less inhibition of cholinesterase than vehicle-treated controls following identical doses of paraoxon, particularly when the organophosphate was given iv or dermally. Organophosphates 168-183 paraoxonase 1 Homo sapiens 21-32 2093766-5 1990 However, when SeLax was crossed to strain Tem-R, which is resistant to organophosphates because of a highly active esterase B1, all possible recombinants occurred. Organophosphates 71-87 esterase B1 Culex quinquefasciatus 115-126 34786760-3 2021 Paraoxonase 1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Organophosphates 27-42 paraoxonase 1 Homo sapiens 0-13 2180130-0 1990 Organophosphates and delayed neuropathy--is NTE alive and well? Organophosphates 0-16 patatin like phospholipase domain containing 6 Homo sapiens 44-47 33031921-0 2020 A single dose of the organophosphate triazophos induces fear extinction deficits accompanied by hippocampal acetylcholinesterase inhibition. Organophosphates 21-36 acetylcholinesterase Rattus norvegicus 108-128 34627797-1 2022 BACKGROUND: Organophosphates are insecticides that inhibit the enzymatic activity of acetylcholinesterase (AChE). Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 34627797-1 2022 BACKGROUND: Organophosphates are insecticides that inhibit the enzymatic activity of acetylcholinesterase (AChE). Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 34627797-2 2022 Because of this, AChE is considered a physiological marker of organophosphate exposure in agricultural settings. Organophosphates 62-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 34627797-3 2022 However, limited research exists on the associations between urinary organophosphate metabolites and AChE activity in children. Organophosphates 69-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34627797-12 2022 CONCLUSIONS: Urinary organophosphate metabolites, including PNP, TCPy and MDA, particularly at concentrations above the 80th percentile, were associated with lower AChE activity among adolescents. Organophosphates 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 34952437-1 2022 Butyrylcholinesterase (BChE) is an important clinical diagnosing index for liver dysfunction and organophosphate toxicity. Organophosphates 97-112 butyrylcholinesterase Homo sapiens 0-21 34952437-1 2022 Butyrylcholinesterase (BChE) is an important clinical diagnosing index for liver dysfunction and organophosphate toxicity. Organophosphates 97-112 butyrylcholinesterase Homo sapiens 23-27 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 2332161-0 1990 Chromosomal organization of the amplified esterase B1 gene in organophosphate-resistant Culex pipiens quinquefasciatus Say (Diptera, Culicidae). Organophosphates 62-77 esterase B1 Culex quinquefasciatus 42-53 2340283-0 1990 Interaction of an organophosphate with a peripheral site on acetylcholinesterase. Organophosphates 18-33 acetylcholinesterase Mus musculus 60-80 2388534-1 1990 Physostigmine (PH), alone, and pyridostigmine (PY), in combination with atropine and 2-PAM, have been shown to protect animals against organophosphate poisoning. Organophosphates 135-150 peptidylglycine alpha-amidating monooxygenase Rattus norvegicus 87-90 33766630-2 2021 We previously reported that NRG1/ErbB signal is responsible for organophosphate (OP)-induced delayed neuropathy (OPIDN) in hens, a susceptive animal model to neuropathic organophosphorous compounds. Organophosphates 64-79 neuregulin 1 Gallus gallus 28-32 33766630-2 2021 We previously reported that NRG1/ErbB signal is responsible for organophosphate (OP)-induced delayed neuropathy (OPIDN) in hens, a susceptive animal model to neuropathic organophosphorous compounds. Organophosphates 64-79 epidermal growth factor receptor Mus musculus 33-37 18322397-1 2008 BACKGROUND: Paraoxonase 1 (PON1) functions to protect the cholinergic system against nerve gases and the organophosphate family of pesticides. Organophosphates 105-120 paraoxonase 1 Homo sapiens 12-25 18322397-1 2008 BACKGROUND: Paraoxonase 1 (PON1) functions to protect the cholinergic system against nerve gases and the organophosphate family of pesticides. Organophosphates 105-120 paraoxonase 1 Homo sapiens 27-31 34884060-0 2021 Colorimetric Detection of Organophosphate Pesticides Based on Acetylcholinesterase and Cysteamine Capped Gold Nanoparticles as Nanozyme. Organophosphates 26-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 34869921-2 2021 The drastic reduction in the sensitivity of insects to AChE-targeting insecticides like organophosphates and carbamates have increased the need for insecticides of natural origin. Organophosphates 88-104 Acetylcholine esterase Drosophila melanogaster 55-59 34786760-3 2021 Paraoxonase 1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Organophosphates 27-42 paraoxonase 1 Homo sapiens 15-19 34888010-2 2021 The main action of organophosphate focuses on acetylcholinesterase inhibition, and it therefore contributes to acute cholinergic crisis, intermediate syndrome and delayed neurotoxicity. Organophosphates 19-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 34558680-2 2022 Here, we describe synthesis, photochemical properties, and biochemical activities of two caged oxime compounds applied in the photocontrolled reactivation of the AChE inactivated by reactive organophosphate. Organophosphates 191-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 82-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 82-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 82-98 butyrylcholinesterase Homo sapiens 50-71 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 82-98 butyrylcholinesterase Homo sapiens 73-77 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 100-103 butyrylcholinesterase Homo sapiens 50-71 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 100-103 butyrylcholinesterase Homo sapiens 73-77 34303790-0 2021 Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components. Organophosphates 17-32 albumin Homo sapiens 77-84 34697648-1 2021 Butyrylcholinesterase (BChE) is an important indicator for clinical diagnosis of liver dysfunction, organophosphate toxicity, and poststroke dementia. Organophosphates 100-115 butyrylcholinesterase Homo sapiens 0-21 34697648-1 2021 Butyrylcholinesterase (BChE) is an important indicator for clinical diagnosis of liver dysfunction, organophosphate toxicity, and poststroke dementia. Organophosphates 100-115 butyrylcholinesterase Homo sapiens 23-27 34289071-0 2021 Bbc3 loss enhances survival and protein clearance in neurons exposed to the organophosphate pesticide chlorpyrifos. Organophosphates 76-91 BCL2 binding component 3 Mus musculus 0-4 34510883-0 2021 Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning. Organophosphates 97-112 butyrylcholinesterase Homo sapiens 54-68 34145064-1 2021 Inhibition of acetylcholinesterase (AChE) by certain organophosphates (OP) can be life-threatening and requires reactivating antidote accessibility to the peripheral and central nervous systems to reverse symptoms and enhance survival parameters. Organophosphates 53-69 acetylcholinesterase Mus musculus 14-34 34265256-1 2021 Current organophosphate (OP) toxicity research now considers potential non-cholinergic mechanisms for these compounds, since the inhibition of acetylcholinesterase (AChE) cannot completely explain all the adverse biological effects of OP. Organophosphates 8-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 34324828-0 2021 Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects. Organophosphates 32-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-28 34324828-5 2021 We also demonstrate the dissociation of organophosphate (OP)-conjugated dimers is reversed by structurally diverse oximes 2PAM, HI6 or RS194B, as demonstrated by SAXS of diethylphosphoryl-hAChE. Organophosphates 40-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-193 34510883-2 2021 We report a case of organophosphate poisoning in which continuous renal replacement therapy (CRRT) was applied with conventional indications and was found to increase plasma cholinesterase levels by hemodiafiltration. Organophosphates 20-35 butyrylcholinesterase Homo sapiens 174-188 34310952-0 2021 Modulation of the Sublingual Microenvironment and pH-Dependent Transport Pathways to Enhance Atropine Sulfate Permeability for the Treatment of Organophosphates Poisoning. Organophosphates 144-160 phenylalanine hydroxylase Homo sapiens 50-52 34145064-1 2021 Inhibition of acetylcholinesterase (AChE) by certain organophosphates (OP) can be life-threatening and requires reactivating antidote accessibility to the peripheral and central nervous systems to reverse symptoms and enhance survival parameters. Organophosphates 53-69 acetylcholinesterase Mus musculus 36-40 34256363-0 2021 A highly sensitive acetylcholinesterase electrochemical biosensor based on Au-Tb alloy nanospheres for determining organophosphate pesticides. Organophosphates 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 34453052-4 2021 Using a step-wise screening approach, we discover that the organophosphate insecticide chlorpyrifos suppresses UCP1 and mitochondrial respiration in BAT at concentrations as low as 1 pM. Organophosphates 59-74 uncoupling protein 1 Homo sapiens 111-115 34259569-4 2021 OBJECTIVES: In this study, we aimed to identify a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 (CHD8) and environmental exposure to an organophosphate pesticide (chlorpyrifos; CPF) in an iPSC-derived human three-dimensional (3D) brain model. Organophosphates 207-222 chromodomain helicase DNA binding protein 8 Homo sapiens 123-166 34322366-4 2021 Children with autism spectrum disorder and attention deficit hyperactivity disorders exhibit decreased or impaired PON1 gene activity which is needed by the body to metabolize and excrete neurotoxic organophosphate pesticides. Organophosphates 199-214 paraoxonase 1 Homo sapiens 115-119 34259569-4 2021 OBJECTIVES: In this study, we aimed to identify a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 (CHD8) and environmental exposure to an organophosphate pesticide (chlorpyrifos; CPF) in an iPSC-derived human three-dimensional (3D) brain model. Organophosphates 207-222 chromodomain helicase DNA binding protein 8 Homo sapiens 168-172 34308007-1 2021 The canonical mechanism of organophosphate (OP) neurotoxicity is the inhibition of acetylcholinesterase (AChE). Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34308007-1 2021 The canonical mechanism of organophosphate (OP) neurotoxicity is the inhibition of acetylcholinesterase (AChE). Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 35491047-0 2022 Acetylcholinesterase-capped mesoporous silica gated switches for selective detection of high-toxicity organophosphate compounds. Organophosphates 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34644031-4 2021 We have identified a complex of deep metabolic disorders and necrobiotic changes in the heart muscle and the level of cholinesterase activity inhibition in the cholinergic structures of the heart in the toxicogenic and somatogenic stages of fatal organophosphate poisoning. Organophosphates 247-262 butyrylcholinesterase Homo sapiens 118-132 35583269-1 2022 Tetraethyl pyrophosphate (TEPP) is an organophosphate pesticide that irreversibly inhibits acetylcholinesterase (AChE). Organophosphates 38-53 acetylcholinesterase Rattus norvegicus 91-111 35583269-1 2022 Tetraethyl pyrophosphate (TEPP) is an organophosphate pesticide that irreversibly inhibits acetylcholinesterase (AChE). Organophosphates 38-53 acetylcholinesterase Rattus norvegicus 113-117 34092762-0 2021 Serum High-sensitivity C-reactive Protein Level and Corrected QT Interval in Agricultural Workers in Myanmar Exposed to Chronic Occupational Organophosphate Pesticides. Organophosphates 141-156 C-reactive protein Homo sapiens 23-41 35623791-9 2022 When the bioactivity of AChE was inhibited by the organophosphate pesticides (chlorpyrifos as substrate), the reduced production of thiocholine resulted in a decline in photocurrent. Organophosphates 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 35522182-4 2022 This study aimed to determine if two polymorphisms of paraoxonase-1 (PON1), which is involved in the metabolism of several organophosphate (OP) pesticides, are predictors of susceptibility to DNA damage in agricultural workers and inhabitants of rural areas chronically exposed to pesticides. Organophosphates 123-138 paraoxonase 1 Homo sapiens 54-67 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Organophosphates 216-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Organophosphates 216-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 35522182-4 2022 This study aimed to determine if two polymorphisms of paraoxonase-1 (PON1), which is involved in the metabolism of several organophosphate (OP) pesticides, are predictors of susceptibility to DNA damage in agricultural workers and inhabitants of rural areas chronically exposed to pesticides. Organophosphates 123-138 paraoxonase 1 Homo sapiens 69-73 35306973-2 2022 Antioxidant paraoxonase enzyme (PON1) has a vital role in the elimination of potential carcinogenic organophosphate molecules. Organophosphates 100-115 paraoxonase 1 Homo sapiens 12-23 35358535-1 2022 Organophosphate (OP) chemicals include commonly used pesticides and chemical warfare agents, and mechanistically they are potent inhibitors of the cholinesterase (ChE) enzyme. Organophosphates 0-15 butyrylcholinesterase Rattus norvegicus 147-161 35358535-1 2022 Organophosphate (OP) chemicals include commonly used pesticides and chemical warfare agents, and mechanistically they are potent inhibitors of the cholinesterase (ChE) enzyme. Organophosphates 0-15 butyrylcholinesterase Rattus norvegicus 163-166 35051466-0 2022 Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells. Organophosphates 0-15 DNA damage inducible transcript 3 Homo sapiens 61-65 35051466-0 2022 Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells. Organophosphates 0-15 caspase 3 Homo sapiens 66-75 35051466-0 2022 Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells. Organophosphates 0-15 superoxide dismutase 1 Homo sapiens 98-102 35051466-0 2022 Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells. Organophosphates 0-15 tumor protein p53 Homo sapiens 103-106 35051466-0 2022 Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells. Organophosphates 0-15 mitogen-activated protein kinase kinase kinase 6 Homo sapiens 107-113 35051466-0 2022 Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells. Organophosphates 0-15 FKBP prolyl isomerase 5 Homo sapiens 114-119 35439576-3 2022 OPs induce neuropathy by either phosphorylating acetyl cholinesterase or neuropathy target esterase, or by binding specifically to nicotinic or muscarinic receptors of nervous system. Organophosphates 0-3 patatin like phospholipase domain containing 6 Homo sapiens 73-99 35320672-5 2022 The outcomes of this study allow us to extend the current understanding beyond organophosphate pesticides" acute toxicity of cholinesterase inhibition to the perturbation of metabolic pathways at dietary intake levels. Organophosphates 79-94 butyrylcholinesterase Homo sapiens 125-139 35448471-2 2022 PNPLA6/NTE was first identified as a key factor in Organophosphate-induced delayed neuropathy, a degenerative syndrome that occurs after exposure to organophosphates found in pesticides and nerve agents. Organophosphates 51-66 patatin like phospholipase domain containing 6 Homo sapiens 0-6 35448471-2 2022 PNPLA6/NTE was first identified as a key factor in Organophosphate-induced delayed neuropathy, a degenerative syndrome that occurs after exposure to organophosphates found in pesticides and nerve agents. Organophosphates 51-66 patatin like phospholipase domain containing 6 Homo sapiens 7-10 35448471-2 2022 PNPLA6/NTE was first identified as a key factor in Organophosphate-induced delayed neuropathy, a degenerative syndrome that occurs after exposure to organophosphates found in pesticides and nerve agents. Organophosphates 149-165 patatin like phospholipase domain containing 6 Homo sapiens 0-6 35448471-2 2022 PNPLA6/NTE was first identified as a key factor in Organophosphate-induced delayed neuropathy, a degenerative syndrome that occurs after exposure to organophosphates found in pesticides and nerve agents. Organophosphates 149-165 patatin like phospholipase domain containing 6 Homo sapiens 7-10 35189179-4 2022 Neurotoxic organophosphate compounds that inhibit AChE, also inhibit butyrylcholinesterase (BChE). Organophosphates 11-26 butyrylcholinesterase Homo sapiens 92-96 35355036-5 2022 The impact of nanoMIPs on the inhibited enzyme is also explored, with AChE activity recovering from 11% (following exposure to an organophosphate) to 73% (following the addition of nanoMIPs). Organophosphates 130-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 35408132-3 2022 It is worth mentioning that organophosphates and carbamates inhibit AChE. Organophosphates 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 35352918-2 2022 Patients symptoms, along with decrease in cholinesterase serum level, determines the possible diagnosis of organophosphate poisoning. Organophosphates 107-122 butyrylcholinesterase Homo sapiens 42-56 35306973-2 2022 Antioxidant paraoxonase enzyme (PON1) has a vital role in the elimination of potential carcinogenic organophosphate molecules. Organophosphates 100-115 paraoxonase 1 Homo sapiens 32-36 35049033-0 2022 Organophosphates modulate tissue transglutaminase activity in differentiated C6 neural cells. Organophosphates 0-16 transglutaminase 2 Homo sapiens 26-49