PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1789189-1	1991	Incorporation of 14C-uridine into UTP and CTP and fluxes of label through these nucleotide pools to RNA and DNA were greater in MOLT-3 cells compared to T-lymphocytes.	Cytidine Triphosphate	42-45	transmembrane protein 132D	Homo sapiens	128-132
1789189-3	1991	Turnover of UTP and CTP however, retained the profile of exponentially growing MOLT-3 cells, implicating the characteristically higher conversion of UTP to CTP is independent of the MOLT-3 cells proliferative capacities.	Cytidine Triphosphate	20-23	transmembrane protein 132D	Homo sapiens	79-83
2049873-14	1991	Competition experiments with GTP gamma S, ATP, GTP, CTP, and uridine triphosphate (UTP) indicated that the phosphate donor site of p36 kinase is relatively non-specific.	Cytidine Triphosphate	52-55	annexin A2	Homo sapiens	131-134
2030604-2	1991	Murine leukemia cells resistant to cytosine arabinoside (ara-C) due to a deletion of deoxycytidine kinase are collaterally sensitive to DAUrd, which inhibits the de novo production of CTP and hence results in dCTP depletion.	Cytidine Triphosphate	184-187	deoxycytidine kinase	Mus musculus	85-105
1986259-4	1991	The APRT-deficient subclones were found to have significantly decreased levels of dATP and dTTP nucleotides and decreased levels of all four ribonucleoside triphosphates (ATP, GTP, CTP and UTP) relative to wild-type cells.	Cytidine Triphosphate	181-184	adenine phosphoribosyl transferase	Mus musculus	4-8
2154953-3	1990	The yield of [3H]PAF could be dramatically increased by pretreating the cells with either oleic acid, an activator of CTP:phosphocholine cytidylyltransferase, or phenylmethylsulfonyl fluoride, an inhibitor of PAF acetylhydrolase.	Cytidine Triphosphate	118-121	PCNA clamp associated factor	Homo sapiens	17-20
2111815-4	1990	Ternary complex formation between eIF-2, GTP, and Met-tRNAf is inhibited effectively by ATP, but not by CTP or UTP.	Cytidine Triphosphate	104-107	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	34-39
2111815-8	1990	Specific complex formation between ATP and eIF-2 is shown 1) by effective retention of Met-tRNAf- and mRNA-binding activities on ATP-agarose and by the ability of free ATP, but not GTP, CTP, or UTP, to effect elution of eIF-2 from this substrate; 2) by eIF-2-dependent retention of [alpha-32P]ATP or dATP on nitrocellulose filters and its inhibition by excess ATP, but not by GTP, CTP, or UTP.	Cytidine Triphosphate	186-189	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	43-48
2111815-8	1990	Specific complex formation between ATP and eIF-2 is shown 1) by effective retention of Met-tRNAf- and mRNA-binding activities on ATP-agarose and by the ability of free ATP, but not GTP, CTP, or UTP, to effect elution of eIF-2 from this substrate; 2) by eIF-2-dependent retention of [alpha-32P]ATP or dATP on nitrocellulose filters and its inhibition by excess ATP, but not by GTP, CTP, or UTP.	Cytidine Triphosphate	381-384	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	43-48
1460049-13	1992	With dA3, dA1, RT, and potassium ions, CTP reduction shows absolute requirements for S-adenosylmethionine, NADPH (with NADH as a less active substitute), dithiothreitol, and magnesium ions, and is strongly stimulated by ATP, probably acting as an allosteric effector.	Cytidine Triphosphate	39-42	A3	Drosophila melanogaster	5-8
2104881-4	1990	Nuclei from the nonproliferating cells (+/- IL-3) showed essentially no incorporation of [3H]thymidine during a 16-h incubation with a mixture of unlabeled GTP, ATP, UTP, CTP, dGTP, dATP, dCTP, and [3H]dTTP.	Cytidine Triphosphate	171-174	interleukin 3	Mus musculus	44-48
28508461-5	2018	RESULTS: The CC and TC genotypes of FOXP3 rs2280883 were associated with a significantly higher risk of connective tissue disease-associated ILD (CTP-ILD) than the TT genotype (P = .006).	Cytidine Triphosphate	146-149	forkhead box P3	Homo sapiens	36-41
28508461-9	2018	CONCLUSION: FOXP3 polymorphisms may be important markers to determine susceptibility to IIP or CTP-ILD in Chinese population.	Cytidine Triphosphate	95-98	forkhead box P3	Homo sapiens	12-17
1460049-13	1992	With dA3, dA1, RT, and potassium ions, CTP reduction shows absolute requirements for S-adenosylmethionine, NADPH (with NADH as a less active substitute), dithiothreitol, and magnesium ions, and is strongly stimulated by ATP, probably acting as an allosteric effector.	Cytidine Triphosphate	39-42	anon-A1	Drosophila melanogaster	10-13
34705862-5	2021	We performed an in-depth characterization of CMPK2 expression, a nucleoside monophosphate kinase that supplies intracellular UTP/CTP for nucleic acid synthesis in response to type I IFN signaling in macrophages.	Cytidine Triphosphate	129-132	cytidine/uridine monophosphate kinase 2	Homo sapiens	45-50
34970928-9	2021	CONCLUSION: The ABC/2 method may be a feasible alternative to RAPID for estimation of target mismatch parameters on CTP in patients with AIS.	Cytidine Triphosphate	116-119	ATP binding cassette subfamily A member 2	Homo sapiens	16-21
34289079-4	2021	Here, we show a mathematical modeling-guided approach to 3"-sialyllactose (3SL) synthesis from N-acetyl-D-neuraminic acid (Neu5Ac) and lactose in the presence of CTP, via the reactions of CMP-Neu5Ac synthetase and alpha2,3-sialyltransferase.	Cytidine Triphosphate	162-165	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	188-209
34612033-6	2021	To overcome the cytidine triphosphate (CTP) cross-inhibition of AGE and NAL, only a low CTP concentration was applied and continuously conveyed through the device.	Cytidine Triphosphate	16-37	renin binding protein	Homo sapiens	64-67
34786174-10	2021	Mean zonulin levels were significantly higher in patients with CTP-B class than CTP-A class (4.2 +- 2.4 ng/dL vs 3.5 +- 0.9 ng/dL, P = 0.038), with than without ascites (P = 0.006), and with than without history of encephalopathy (P = 0.011).	Cytidine Triphosphate	63-66	haptoglobin	Homo sapiens	5-12
34612033-6	2021	To overcome the cytidine triphosphate (CTP) cross-inhibition of AGE and NAL, only a low CTP concentration was applied and continuously conveyed through the device.	Cytidine Triphosphate	16-37	N-acetylneuraminate pyruvate lyase	Homo sapiens	72-75
34612033-6	2021	To overcome the cytidine triphosphate (CTP) cross-inhibition of AGE and NAL, only a low CTP concentration was applied and continuously conveyed through the device.	Cytidine Triphosphate	39-42	renin binding protein	Homo sapiens	64-67
34612033-6	2021	To overcome the cytidine triphosphate (CTP) cross-inhibition of AGE and NAL, only a low CTP concentration was applied and continuously conveyed through the device.	Cytidine Triphosphate	39-42	N-acetylneuraminate pyruvate lyase	Homo sapiens	72-75
34612033-6	2021	To overcome the cytidine triphosphate (CTP) cross-inhibition of AGE and NAL, only a low CTP concentration was applied and continuously conveyed through the device.	Cytidine Triphosphate	88-91	renin binding protein	Homo sapiens	64-67
34582526-6	2021	CTP-IAGIP further induced IL-10 production in the inflamed colonic tissues; however, the levels of IL-10 were not affected in the normal colonic tissue or colonic tissue in which inflammation had subsided.	Cytidine Triphosphate	0-3	interleukin 10	Rattus norvegicus	26-31
34255834-8	2021	By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP.	Cytidine Triphosphate	276-279	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	89-132
34255834-8	2021	By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP.	Cytidine Triphosphate	276-279	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	134-139
34255834-8	2021	By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP.	Cytidine Triphosphate	276-279	cut-like homeobox 1	Mus musculus	211-214
34255834-8	2021	By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP.	Cytidine Triphosphate	276-279	chemokine (C-X-C motif) ligand 1	Mus musculus	215-218
34583994-2	2021	CTPS1 expression is up-regulated in activated lymphocytes to expand CTP pools (E. Martin et al), (Nature) (510), (288-292) ((2014)), satisfying increased demand for nucleic acid and lipid synthesis (L. D. Fairbanks, M. Bofill, K. Ruckemann, H. A. Simmonds), (J. Biol.	Cytidine Triphosphate	68-71	CTP synthase 1	Homo sapiens	0-5
34583994-5	2021	Demand for CTP in other tissues is met by the CTPS2 isoform and nucleoside salvage pathways (E. Martin et al), (Nature) (510), (288-292) ((2014)).	Cytidine Triphosphate	11-14	CTP synthase 2	Homo sapiens	46-51
34583994-8	2021	CTPS1 is less sensitive to CTP feedback inhibition, consistent with its role in increasing CTP levels in proliferation.	Cytidine Triphosphate	27-30	CTP synthase 1	Homo sapiens	0-5
34583994-8	2021	CTPS1 is less sensitive to CTP feedback inhibition, consistent with its role in increasing CTP levels in proliferation.	Cytidine Triphosphate	91-94	CTP synthase 1	Homo sapiens	0-5
34583994-10	2021	Cryo-electron microscopy (cryo-EM) structures reveal these inhibitors mimic CTP binding in one inhibitory site, where a single amino acid substitution explains selectivity for CTPS1.	Cytidine Triphosphate	76-79	CTP synthase 1	Homo sapiens	176-181
34381216-4	2021	Biochemical assays show that the RdRp uses the active form of molnupiravir, beta-D-N4-hydroxycytidine (NHC) triphosphate, as a substrate instead of cytidine triphosphate or uridine triphosphate.	Cytidine Triphosphate	148-169	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	33-37
34281398-3	2021	Since CTP is a critical precursor for DNA, RNA, and phospholipid synthesis, this observation raises the question of whether the isozyme CTPS2 or cytidine salvage pathways help meet CTP demand in EBV-infected B cells.	Cytidine Triphosphate	6-9	CTP synthase 2	Homo sapiens	136-141
34129847-1	2021	Cytidine triphosphate synthase (CTPS) catalyzes the rate-limiting step of de novo CTP biosynthesis.	Cytidine Triphosphate	82-85	CTP synthase 1a	Danio rerio	0-30
34129847-1	2021	Cytidine triphosphate synthase (CTPS) catalyzes the rate-limiting step of de novo CTP biosynthesis.	Cytidine Triphosphate	82-85	CTP synthase 1a	Danio rerio	32-36
34977618-9	2021	FACS analysis revealed high positivity rates (>95%) of CTP-specific surface epitopes (CD105, CD90, and CD73) and low positivity rates (<1.3%) of negative markers (CD45, CD31).	Cytidine Triphosphate	55-58	Thy-1 cell surface antigen	Homo sapiens	93-97
34977618-9	2021	FACS analysis revealed high positivity rates (>95%) of CTP-specific surface epitopes (CD105, CD90, and CD73) and low positivity rates (<1.3%) of negative markers (CD45, CD31).	Cytidine Triphosphate	55-58	5'-nucleotidase ecto	Homo sapiens	103-107
34399762-7	2021	In terms of anti-tumor mechanism, CTP/CDDP reduced CDDP efflux and inhibited epithelial-mesenchymal transition (EMT) process of tumor by down-regulating hypoxia-inducible factor-1alpha (HIF-1alpha), glutathione (GSH), multidrug resistance-associated protein 2 (MRP2) and matrix metalloproteinase 9 (MMP9) expression, thus reversing drug resistance and metastasis of hypoxic tumor cells.	Cytidine Triphosphate	34-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-184
34399762-7	2021	In terms of anti-tumor mechanism, CTP/CDDP reduced CDDP efflux and inhibited epithelial-mesenchymal transition (EMT) process of tumor by down-regulating hypoxia-inducible factor-1alpha (HIF-1alpha), glutathione (GSH), multidrug resistance-associated protein 2 (MRP2) and matrix metalloproteinase 9 (MMP9) expression, thus reversing drug resistance and metastasis of hypoxic tumor cells.	Cytidine Triphosphate	34-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	186-196
34399762-7	2021	In terms of anti-tumor mechanism, CTP/CDDP reduced CDDP efflux and inhibited epithelial-mesenchymal transition (EMT) process of tumor by down-regulating hypoxia-inducible factor-1alpha (HIF-1alpha), glutathione (GSH), multidrug resistance-associated protein 2 (MRP2) and matrix metalloproteinase 9 (MMP9) expression, thus reversing drug resistance and metastasis of hypoxic tumor cells.	Cytidine Triphosphate	34-37	ATP binding cassette subfamily C member 2	Homo sapiens	218-259
34399762-7	2021	In terms of anti-tumor mechanism, CTP/CDDP reduced CDDP efflux and inhibited epithelial-mesenchymal transition (EMT) process of tumor by down-regulating hypoxia-inducible factor-1alpha (HIF-1alpha), glutathione (GSH), multidrug resistance-associated protein 2 (MRP2) and matrix metalloproteinase 9 (MMP9) expression, thus reversing drug resistance and metastasis of hypoxic tumor cells.	Cytidine Triphosphate	34-37	ATP binding cassette subfamily C member 2	Homo sapiens	261-265
34399762-7	2021	In terms of anti-tumor mechanism, CTP/CDDP reduced CDDP efflux and inhibited epithelial-mesenchymal transition (EMT) process of tumor by down-regulating hypoxia-inducible factor-1alpha (HIF-1alpha), glutathione (GSH), multidrug resistance-associated protein 2 (MRP2) and matrix metalloproteinase 9 (MMP9) expression, thus reversing drug resistance and metastasis of hypoxic tumor cells.	Cytidine Triphosphate	34-37	matrix metallopeptidase 9	Homo sapiens	271-297
34399762-7	2021	In terms of anti-tumor mechanism, CTP/CDDP reduced CDDP efflux and inhibited epithelial-mesenchymal transition (EMT) process of tumor by down-regulating hypoxia-inducible factor-1alpha (HIF-1alpha), glutathione (GSH), multidrug resistance-associated protein 2 (MRP2) and matrix metalloproteinase 9 (MMP9) expression, thus reversing drug resistance and metastasis of hypoxic tumor cells.	Cytidine Triphosphate	34-37	matrix metallopeptidase 9	Homo sapiens	299-303
34301892-1	2021	Cytidine triphosphate synthase (CTPS), which comprises an ammonia ligase domain and a glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis.	Cytidine Triphosphate	157-160	CTP synthase	Drosophila melanogaster	0-30
34132576-18	2021	Inhibition of ATPase activity of betaC1 in the presence of an excess concentration of cold ATP, GTP, CTP or UTP suggested that the purified betaC1 can also hydrolyze other cellular NTPs besides ATP in vitro.	Cytidine Triphosphate	101-104	adenylate cyclase 1	Homo sapiens	33-39
34132576-18	2021	Inhibition of ATPase activity of betaC1 in the presence of an excess concentration of cold ATP, GTP, CTP or UTP suggested that the purified betaC1 can also hydrolyze other cellular NTPs besides ATP in vitro.	Cytidine Triphosphate	101-104	adenylate cyclase 1	Homo sapiens	140-146
34301892-1	2021	Cytidine triphosphate synthase (CTPS), which comprises an ammonia ligase domain and a glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis.	Cytidine Triphosphate	157-160	CTP synthase	Drosophila melanogaster	32-36
34301892-10	2021	Our findings not only delineate the structure of CTPS in the presence of all substrates but also complete our understanding of the underlying mechanisms of the allosteric regulation and CTP synthesis.	Cytidine Triphosphate	186-189	CTP synthase	Drosophila melanogaster	49-53
35007755-1	2022	Cytidine triphosphate:phosphocholine cytidylyltransferase-alpha (CTalpha) is the rate limiting enzyme in the pathway for de novo phosphatidylcholine (PC) synthesis.	Cytidine Triphosphate	0-21	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	65-72
35427600-1	2022	CTP synthase (CTPS), the enzyme responsible for the last step of de novo synthesis of CTP, forms filamentous structures termed cytoophidia in all three domains of life.	Cytidine Triphosphate	86-89	CTP synthase	Drosophila melanogaster	0-12
35427600-1	2022	CTP synthase (CTPS), the enzyme responsible for the last step of de novo synthesis of CTP, forms filamentous structures termed cytoophidia in all three domains of life.	Cytidine Triphosphate	86-89	CTP synthase	Drosophila melanogaster	14-18
35633731-2	2022	Cytidine/uridine monophosphate kinase 2 (CMPK2) gene has been identified as an ISG in human and fish, and is also known as a rate-limiting enzyme in mitochondria to maintain intracellular UTP/CTP levels, which is necessary for de novo mitochondrial DNA synthesis.	Cytidine Triphosphate	192-195	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-39
35633731-2	2022	Cytidine/uridine monophosphate kinase 2 (CMPK2) gene has been identified as an ISG in human and fish, and is also known as a rate-limiting enzyme in mitochondria to maintain intracellular UTP/CTP levels, which is necessary for de novo mitochondrial DNA synthesis.	Cytidine Triphosphate	192-195	cytidine/uridine monophosphate kinase 2	Homo sapiens	41-46
35574050-5	2023	Further, CTP-MSCs inhibited extracellular matrix degradation in interleukin-1beta-induced chondrocytes.	Cytidine Triphosphate	9-12	interleukin 1 beta	Mus musculus	64-81
35509869-12	2022	In patients with epidermal growth factor receptor (EGFR) amplification tumors (15.7%), PFS was improved with CTP compared with TP treatment (HR = 0.11; 95% CI: 0.01-0.98; p = 0.018).	Cytidine Triphosphate	109-112	epidermal growth factor receptor	Homo sapiens	17-49
35509869-12	2022	In patients with epidermal growth factor receptor (EGFR) amplification tumors (15.7%), PFS was improved with CTP compared with TP treatment (HR = 0.11; 95% CI: 0.01-0.98; p = 0.018).	Cytidine Triphosphate	109-112	epidermal growth factor receptor	Homo sapiens	51-55
35218663-11	2022	CONCLUSIONS: CTP was able to detect irreversible ischaemic core, guide critical decisions in preoperative patients and aid in determining the blood pressure augmentation for postoperative management focusing on residual brain ischaemia.	Cytidine Triphosphate	13-16	activation induced cytidine deaminase	Homo sapiens	119-122
34286695-0	2021	CTP and parS coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning.	Cytidine Triphosphate	0-3	dynein axonemal heavy chain 8	Homo sapiens	65-71
34156827-2	2021	We recently demonstrated that human viperin (HsVip) catalyzes the conversion of CTP to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP or ddh-synthase), which acts as a chain terminator for virally encoded RNA-dependent RNA polymerases from several flaviviruses.	Cytidine Triphosphate	80-83	radical S-adenosyl methionine domain containing 2	Homo sapiens	36-43
34156827-7	2021	Furthermore, we define the unique chemical and physical determinants supporting ddh-synthase activity and nucleotide selectivity, including the crystallographic characterization of a fungal viperin-like enzyme that utilizes UTP as a substrate and a cnidaria viperin-like enzyme that utilizes CTP as a substrate.	Cytidine Triphosphate	292-295	radical S-adenosyl methionine domain containing 2	Homo sapiens	258-265
34209567-5	2021	DNA microarray and RT-qPCR analyses showed that CTP treatment recovered the downregulated expression of several genes, including the interleukin-3 receptor subunit alpha (IL3RA), which were suppressed by reactive oxygen species (ROS) treatment in HAECs.	Cytidine Triphosphate	48-51	interleukin 3 receptor subunit alpha	Homo sapiens	133-169
34209567-5	2021	DNA microarray and RT-qPCR analyses showed that CTP treatment recovered the downregulated expression of several genes, including the interleukin-3 receptor subunit alpha (IL3RA), which were suppressed by reactive oxygen species (ROS) treatment in HAECs.	Cytidine Triphosphate	48-51	interleukin 3 receptor subunit alpha	Homo sapiens	171-176
35227600-11	2022	G-CSF plus GH and G-CSF plus EPO had advantages in terms of CTP scores.	Cytidine Triphosphate	60-63	colony stimulating factor 3	Homo sapiens	18-23
35625575-1	2022	Cytidine-5"-triphosphate (CTP) synthase (CTPS) is the class I glutamine-dependent amidotransferase (GAT) that catalyzes the last step in the de novo biosynthesis of CTP.	Cytidine Triphosphate	165-168	CTP synthase	Drosophila melanogaster	0-39
35625575-1	2022	Cytidine-5"-triphosphate (CTP) synthase (CTPS) is the class I glutamine-dependent amidotransferase (GAT) that catalyzes the last step in the de novo biosynthesis of CTP.	Cytidine Triphosphate	165-168	GABA transporter	Drosophila melanogaster	62-98
35625575-1	2022	Cytidine-5"-triphosphate (CTP) synthase (CTPS) is the class I glutamine-dependent amidotransferase (GAT) that catalyzes the last step in the de novo biosynthesis of CTP.	Cytidine Triphosphate	165-168	GABA transporter	Drosophila melanogaster	100-103
35625575-2	2022	Glutamine hydrolysis is catalyzed in the GAT domain and the liberated ammonia is transferred via an intramolecular tunnel to the synthase domain where the ATP-dependent amination of UTP occurs to form CTP.	Cytidine Triphosphate	201-204	GABA transporter	Drosophila melanogaster	41-44
35566067-7	2022	The CTP supplement increased the expression of IGF-1, PI3K/AKT, and mTOR, whereas the CP supplement increased the expression of IGF-1 and AMPK in the gastrocnemius of aging mice.	Cytidine Triphosphate	4-7	insulin-like growth factor 1	Mus musculus	47-52
35566067-7	2022	The CTP supplement increased the expression of IGF-1, PI3K/AKT, and mTOR, whereas the CP supplement increased the expression of IGF-1 and AMPK in the gastrocnemius of aging mice.	Cytidine Triphosphate	4-7	thymoma viral proto-oncogene 1	Mus musculus	59-62
35566067-7	2022	The CTP supplement increased the expression of IGF-1, PI3K/AKT, and mTOR, whereas the CP supplement increased the expression of IGF-1 and AMPK in the gastrocnemius of aging mice.	Cytidine Triphosphate	4-7	mechanistic target of rapamycin kinase	Mus musculus	68-72
35239666-6	2022	Disruption of the inducible CTP synthase under DON exposure hyper-activates the Mec1-Rad53 DNA damage response (DDR) pathway, which prevents chromosome breakage.	Cytidine Triphosphate	28-31	protein kinase MEC1	Saccharomyces cerevisiae S288C	80-84
35239666-6	2022	Disruption of the inducible CTP synthase under DON exposure hyper-activates the Mec1-Rad53 DNA damage response (DDR) pathway, which prevents chromosome breakage.	Cytidine Triphosphate	28-31	serine/threonine/tyrosine protein kinase RAD53	Saccharomyces cerevisiae S288C	85-90
35154622-4	2022	From 2017 to 2020, 124 CS patients who underwent carotid endarterectomy (CEA) with both preoperative CTP and digital substruction angiography (DSA) images were enrolled.	Cytidine Triphosphate	101-104	citrate synthase	Homo sapiens	23-25
35359496-3	2022	Interestingly, even though the STC(D/Y) motif in AIP-I/IV is a member of the SX1CX2 motif family, it maintains the CTP form.	Cytidine Triphosphate	115-118	stanniocalcin 1	Homo sapiens	31-34
2482285-7	1989	In the Western blot using anti-hCGbeta or anti-hCGbeta-CTP under reducing conditions, the urine presented a new band (CTP") with Mr 23,000 in addition to the beta-subunit, while the serum revealed a single band of the beta-subunit with or without a reducing reagent.	Cytidine Triphosphate	55-58	chorionic gonadotropin subunit beta 3	Homo sapiens	47-54
2482285-7	1989	In the Western blot using anti-hCGbeta or anti-hCGbeta-CTP under reducing conditions, the urine presented a new band (CTP") with Mr 23,000 in addition to the beta-subunit, while the serum revealed a single band of the beta-subunit with or without a reducing reagent.	Cytidine Triphosphate	118-121	chorionic gonadotropin subunit beta 3	Homo sapiens	31-38
2482285-7	1989	In the Western blot using anti-hCGbeta or anti-hCGbeta-CTP under reducing conditions, the urine presented a new band (CTP") with Mr 23,000 in addition to the beta-subunit, while the serum revealed a single band of the beta-subunit with or without a reducing reagent.	Cytidine Triphosphate	118-121	chorionic gonadotropin subunit beta 3	Homo sapiens	47-54
2552440-4	1989	ATPase (dATPase) is specific for adenine nucleotides; ATP and dATP, but not CTP, UTP, or GTP, are hydrolyzed.	Cytidine Triphosphate	76-79	Vacuolar H[+] ATPase 14kD subunit 1	Drosophila melanogaster	0-6
2552440-4	1989	ATPase (dATPase) is specific for adenine nucleotides; ATP and dATP, but not CTP, UTP, or GTP, are hydrolyzed.	Cytidine Triphosphate	76-79	Vacuolar H[+] ATPase 14kD subunit 1	Drosophila melanogaster	8-15
2713347-1	1989	Transient kinetic data of the hydrolysis of several nucleotides (TTP, CTP, UTP, GTP) by cardiac myosin subfragment 1 (S1) were analyzed to obtain values for the equilibrium constant for nucleotide binding and rate constants for the S1-nucleotide isomerization and the subsequent nucleotide hydrolysis as well as the magnitudes of the relative fluorescence enhancements of the myosin that occur upon isomerization and hydrolysis.	Cytidine Triphosphate	70-73	myosin heavy chain 14	Homo sapiens	96-102
2452075-16	1988	Since the sialylated peptide beta 115-141 binds poorly to it, this antiserum resembles the carbohydrate-oblivious anti-beta CTP; both require the COOH-terminal amino acids of hCG beta.	Cytidine Triphosphate	124-127	chorionic gonadotropin subunit beta 3	Homo sapiens	175-183
2906879-1	1988	In the present study the opioid receptor antagonist properties of the conformationally constrained cyclic octapeptide D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP), which is derived from somatostatin, were investigated, using in vitro functional paradigms of central mu-, delta- and kappa-opioid receptors.	Cytidine Triphosphate	159-162	opioid receptor kappa 1	Homo sapiens	272-305
3141077-6	1988	The K 1/2 for GTP activation of papilloma ODC was approximately 7 x 10(-9) M. When a series of nucleotides was tested, only GTP, the non-hydrolysable analog GTP gamma S, dGTP and GDP were capable of significant activation at 1 microM, while other derivatives including GMP, ATP and CTP were less effective.	Cytidine Triphosphate	282-285	ornithine decarboxylase, structural 1	Mus musculus	42-45
2457581-17	1988	Both the ecto-ATPase and the (Ca2+-Mg2+)-ATPase have broad nucleotide-hydrolyzing activity, i.e. they both hydrolyze ATP, GTP, UTP, CTP, ADP, and GDP to a similar extent.	Cytidine Triphosphate	132-135	CEA cell adhesion molecule 1	Rattus norvegicus	9-20
2454807-1	1988	When human chorionic gonadotropin (hCG) was subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions with dithiothreitol (DTT), a smaller weight material (CTP"), in addition to the beta-subunit, could be detected by Western blot analysis using antiserum for hCG beta-carboxy-terminal peptide (CTP).	Cytidine Triphosphate	195-198	chorionic gonadotropin subunit beta 5	Homo sapiens	11-39
2454807-1	1988	When human chorionic gonadotropin (hCG) was subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions with dithiothreitol (DTT), a smaller weight material (CTP"), in addition to the beta-subunit, could be detected by Western blot analysis using antiserum for hCG beta-carboxy-terminal peptide (CTP).	Cytidine Triphosphate	333-336	chorionic gonadotropin subunit beta 5	Homo sapiens	11-39
3049549-5	1988	The effectiveness of NTPs in promoting LexA cleavage by RecA1202 and RecA1211 proteins decreased in roughly the following order: dATP greater than ATP greater than UTP greater than ATP-gamma S greater than dCTP greater than CTP greater than dGTP greater than GTP greater than TTP.	Cytidine Triphosphate	207-210	DNA repair system	Escherichia coli	39-43
3367156-8	1988	Since CTP: phosphocholine cytidyltransferase is inactivated by phosphorylation and since there is independent evidence for hyperphosphorylation of tau and MAP-2 proteins in AD brain, enhanced protein kinase activity could be a common factor.	Cytidine Triphosphate	6-9	microtubule associated protein 2	Homo sapiens	155-160
2893798-4	1988	The limiting step in phosphatidylcholine biosynthesis was the formation of CDP-choline catalyzed by CTP:choline-phosphate cytidylyltransferase (EC 2.7.7.15) as monitored by the decrease in phosphocholine labeling following phospholipase C treatment of cells prelabeled with [3H]choline.	Cytidine Triphosphate	100-103	cut like homeobox 1	Homo sapiens	75-78
2834473-5	1988	Western blotting using anti-hCG beta-carboxy-terminal peptides (CTP) revealed a single band corresponding to hCG beta.	Cytidine Triphosphate	64-67	chorionic gonadotropin subunit beta 3	Homo sapiens	28-36
2834473-5	1988	Western blotting using anti-hCG beta-carboxy-terminal peptides (CTP) revealed a single band corresponding to hCG beta.	Cytidine Triphosphate	64-67	chorionic gonadotropin subunit beta 3	Homo sapiens	109-117
3467314-7	1986	The papilloma OrnDCases, but not epidermal OrnDCase, were activated by GTP and to a lesser extent by CTP.	Cytidine Triphosphate	101-104	ornithine decarboxylase, structural 1	Mus musculus	14-22
2966145-5	1987	The purified ATPase hydrolyzed ATP, GTP, ITP, and CTP but not UTP, ADP, AMP, or p-nitrophenylphosphate.	Cytidine Triphosphate	50-53	ATZ20_RS04105	Sulfolobus acidocaldarius	13-19
3333197-2	1987	A 28-mer oligonucleotide probe complementary to a distinctive region of NPY mRNA was 3"-end labeled with [35S]-deoxycytosine triphosphate ([35S]-dCTP) by using terminal transferase and was hybridized to fixed sections of rat and mouse brain.	Cytidine Triphosphate	111-137	neuropeptide Y	Rattus norvegicus	72-75
3782420-1	1986	We developed a highly sensitive and specific assay for hCG using monoclonal antibodies (Mabs) directed against a 37-amino acid synthetic polypeptide analogous to the carboxyl-terminus (CTP) of beta hCG.	Cytidine Triphosphate	185-188	chorionic gonadotropin subunit beta 5	Homo sapiens	55-58
3782420-1	1986	We developed a highly sensitive and specific assay for hCG using monoclonal antibodies (Mabs) directed against a 37-amino acid synthetic polypeptide analogous to the carboxyl-terminus (CTP) of beta hCG.	Cytidine Triphosphate	185-188	chorionic gonadotropin subunit beta 5	Homo sapiens	198-201
3782420-5	1986	Serum levels of hCG or hCG-like material with CTP structure were measured in 229 healthy blood donors; 1.1% of healthy men and 4.6% of nonpregnant women younger than 50 yr had serum values varying between 0.05 and 0.23 ng/ml.	Cytidine Triphosphate	46-49	chorionic gonadotropin subunit beta 5	Homo sapiens	16-19
3782420-5	1986	Serum levels of hCG or hCG-like material with CTP structure were measured in 229 healthy blood donors; 1.1% of healthy men and 4.6% of nonpregnant women younger than 50 yr had serum values varying between 0.05 and 0.23 ng/ml.	Cytidine Triphosphate	46-49	chorionic gonadotropin subunit beta 5	Homo sapiens	23-26
2840195-2	1988	Data show the presence of a myokinase-type enzyme activity (CTP:CMP phosphotransferase) which catalyzes the reaction: 2CDP in equilibrium CMP + CTP.	Cytidine Triphosphate	60-63	cut-like homeobox 1	Mus musculus	119-122
2840195-2	1988	Data show the presence of a myokinase-type enzyme activity (CTP:CMP phosphotransferase) which catalyzes the reaction: 2CDP in equilibrium CMP + CTP.	Cytidine Triphosphate	144-147	cut-like homeobox 1	Mus musculus	119-122
3115930-8	1987	All five choriocarcinoma hCG samples were much more susceptible than standard hCG to cleavage of CTP" by DTT.	Cytidine Triphosphate	97-100	chorionic gonadotropin subunit beta 5	Homo sapiens	25-28
3115930-8	1987	All five choriocarcinoma hCG samples were much more susceptible than standard hCG to cleavage of CTP" by DTT.	Cytidine Triphosphate	97-100	chorionic gonadotropin subunit beta 5	Homo sapiens	78-81
3665991-13	1987	Thus, 5"-GMP or 5"-GDP strongly enhanced the antitumor activity of FUra, and the potentiation resulted from the inhibition of RNA synthesis caused by reduction of the CTP and UTP pool sizes and increased incorporation of FUra into RNA.	Cytidine Triphosphate	167-170	5'-nucleotidase, cytosolic II	Homo sapiens	9-12
3032270-4	1987	Pulse-chase studies indicate that CTP:cholinephosphate cytidylyltransferase might be subject to hormonal regulation by vasopressin.	Cytidine Triphosphate	34-37	arginine vasopressin	Rattus norvegicus	119-130
3645545-8	1987	TRV RNA2 can be adenylated with CTP, ATP; tRNA nucleotidyl transferase and ATP.	Cytidine Triphosphate	32-35	tRNA-Val (anticodon AAC) 1-4	Homo sapiens	0-3
3539181-4	1986	Similar competition studies also showed that nearly all of the other nucleotide triphosphates also bind to recA protein, with the affinity decreasing in the following order: UTP greater than GTP approximately equal to dCTP greater than dGTP greater than CTP.	Cytidine Triphosphate	219-222	RAD51 recombinase	Homo sapiens	107-111
3015191-4	1986	CTP inhibited the activity of hexokinase in a competitive manner for ATP (Mg-ATP2-) with a Ki of 4 mmol/l.	Cytidine Triphosphate	0-3	hexokinase 1	Homo sapiens	30-40
3459463-8	1986	These results indicate that the reduction in CTP levels leads to rapid inhibition of DNA synthesis and reduction in c-myc mRNA levels which precede the appearance of differentiated cells.	Cytidine Triphosphate	45-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	116-121
2821233-10	1987	There is an absolute requirement for adenosine 5"-triphosphate (ATP) for the secretion of lysozyme, but beta-glucuronidase secretion can be partly supported by other nucleoside triphosphates in the order guanosine 5"-triphosphate (GTP) greater than uridine 5"-triphosphate (UTP) = xanthosine 5"-triphosphate (XTP) greater than cytidine 5"-triphosphate (CTP).	Cytidine Triphosphate	327-351	glucuronidase beta	Homo sapiens	104-122
2821233-10	1987	There is an absolute requirement for adenosine 5"-triphosphate (ATP) for the secretion of lysozyme, but beta-glucuronidase secretion can be partly supported by other nucleoside triphosphates in the order guanosine 5"-triphosphate (GTP) greater than uridine 5"-triphosphate (UTP) = xanthosine 5"-triphosphate (XTP) greater than cytidine 5"-triphosphate (CTP).	Cytidine Triphosphate	353-356	glucuronidase beta	Homo sapiens	104-122
2418956-3	1986	CTP-directed RIA recognized a peak of hCG beta-like immunoreactive material that eluted in the same position as standard hCG beta.	Cytidine Triphosphate	0-3	chorionic gonadotropin subunit beta 3	Homo sapiens	38-46
2418956-3	1986	CTP-directed RIA recognized a peak of hCG beta-like immunoreactive material that eluted in the same position as standard hCG beta.	Cytidine Triphosphate	0-3	chorionic gonadotropin subunit beta 3	Homo sapiens	121-129
2426095-2	1986	Infusions of hCG beta, as-hCG, or intact hCG resulted in accumulation in the kidney of a large quantity of small mol wt peptides lacking the immunological determinants of the carboxy-terminal peptide (CTP) of the beta-subunit.	Cytidine Triphosphate	201-204	chorionic gonadotropin subunit beta 3	Homo sapiens	13-21
2426095-2	1986	Infusions of hCG beta, as-hCG, or intact hCG resulted in accumulation in the kidney of a large quantity of small mol wt peptides lacking the immunological determinants of the carboxy-terminal peptide (CTP) of the beta-subunit.	Cytidine Triphosphate	201-204	chorionic gonadotropin subunit beta 5	Homo sapiens	13-16
2426095-2	1986	Infusions of hCG beta, as-hCG, or intact hCG resulted in accumulation in the kidney of a large quantity of small mol wt peptides lacking the immunological determinants of the carboxy-terminal peptide (CTP) of the beta-subunit.	Cytidine Triphosphate	201-204	chorionic gonadotropin subunit beta 5	Homo sapiens	26-29
3525156-9	1986	In the presence of CTP and vanadate (phosphatase inhibitors) insulin-stimulatable tyrosine-specific phosphorylation of exogenous substrates was demonstrated with chicken liver and brain receptors.	Cytidine Triphosphate	19-22	insulin	Gallus gallus	61-68
4091816-2	1985	The kinetics of assembly of MAP2-tubulin microtubule protein were examined as a function of the GTP concentration in order to test the hypothesis that CTP-induced assembly results from the generation of GTP by nucleoside diphosphate kinase.	Cytidine Triphosphate	151-154	microtubule associated protein 2	Homo sapiens	28-32
3877250-10	1985	High energy phosphate compounds (ATP, ADP, CTP, and others) displaced mitochondria-bound hexokinase, which increased the cytosolic form by 2-fold in the glioma lines, but fibroblast hexokinase distribution was unaffected.	Cytidine Triphosphate	43-46	hexokinase 1	Homo sapiens	89-99
2991218-9	1985	Endogenous myosin light chain kinase is not active in solutions containing CTP and dephosphorylation of myosin light chains occurs in CTP solutions both in the presence and absence of Ca2+.	Cytidine Triphosphate	134-137	myosin, heavy chain 15	Gallus gallus	11-17
2991218-9	1985	Endogenous myosin light chain kinase is not active in solutions containing CTP and dephosphorylation of myosin light chains occurs in CTP solutions both in the presence and absence of Ca2+.	Cytidine Triphosphate	134-137	myosin, heavy chain 15	Gallus gallus	104-110
3971913-12	1985	In addition, other nucleoside triphosphates (CTP, GTP, and UTP) were also effective in inducing the 8S to 4S transformation of the unoccupied and the steroid-bound PR.	Cytidine Triphosphate	45-48	progesterone receptor	Gallus gallus	164-166
2982418-7	1985	A marked increase in CTP: phosphorylcholine cytidylyltransferase activity was found after treatment of the cultures with phospholipase C.	Cytidine Triphosphate	21-24	LOC100009319	Oryctolagus cuniculus	121-136
6230223-8	1984	Incubation with GTP, ITP, CTP, TTP, and UTP resulted in augmentation of hormone release duplicating that seen with ATP.	Cytidine Triphosphate	26-29	ATPase phospholipid transporting 8A2	Homo sapiens	115-118
6289944-4	1982	Glucose-6-phosphate dehydrogenase (G6PD) activity in hemolysates from control erythrocytes was inhibited 43% by 5.5 mM cytidine 5"-triphosphate (CTP) and 50% by 5.5 mM in uridine 5"-triphosphate (UTP) at pH 7.1.	Cytidine Triphosphate	119-143	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
6098441-5	1984	The apparent Km of the enzyme for dUTP and dTTP was approximately 20 mumol/l while the apparent Km for dATP, ATP, dCTP, CTP and UTP was in the range of 65-80 mumol/l.	Cytidine Triphosphate	115-118	ttp	Drosophila melanogaster	43-47
6195275-1	1983	A radioimmunoassay (CTP-RIA) for urinary human chorionic gonadotropin (hCG) with the use of an antiserum to be carboxyl-terminal peptide of hCG beta subunit was employed to detect hCG production in patients with gestational trophoblastic disease.	Cytidine Triphosphate	20-23	hypertrichosis 2 (generalised, congenital)	Homo sapiens	71-74
6195275-1	1983	A radioimmunoassay (CTP-RIA) for urinary human chorionic gonadotropin (hCG) with the use of an antiserum to be carboxyl-terminal peptide of hCG beta subunit was employed to detect hCG production in patients with gestational trophoblastic disease.	Cytidine Triphosphate	20-23	hypertrichosis 2 (generalised, congenital)	Homo sapiens	140-143
6195275-1	1983	A radioimmunoassay (CTP-RIA) for urinary human chorionic gonadotropin (hCG) with the use of an antiserum to be carboxyl-terminal peptide of hCG beta subunit was employed to detect hCG production in patients with gestational trophoblastic disease.	Cytidine Triphosphate	20-23	hypertrichosis 2 (generalised, congenital)	Homo sapiens	140-143
6195275-10	1983	This specific and sensitive CTP-RIA method for the detection of hCG production was found to improve the ability to diagnose persistent or recurrent trophoblastic disease.	Cytidine Triphosphate	28-31	hypertrichosis 2 (generalised, congenital)	Homo sapiens	64-67
6185587-4	1983	The same cross-reactivity was observed with CTP 34 B4 (murine x human) somatic hybrid cells, which express class I molecules constituted of human HLA heavy chains and murine beta 2-m.	Cytidine Triphosphate	44-47	beta-2 microglobulin	Mus musculus	174-182
6289944-4	1982	Glucose-6-phosphate dehydrogenase (G6PD) activity in hemolysates from control erythrocytes was inhibited 43% by 5.5 mM cytidine 5"-triphosphate (CTP) and 50% by 5.5 mM in uridine 5"-triphosphate (UTP) at pH 7.1.	Cytidine Triphosphate	119-143	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
6289944-4	1982	Glucose-6-phosphate dehydrogenase (G6PD) activity in hemolysates from control erythrocytes was inhibited 43% by 5.5 mM cytidine 5"-triphosphate (CTP) and 50% by 5.5 mM in uridine 5"-triphosphate (UTP) at pH 7.1.	Cytidine Triphosphate	145-148	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
6289944-4	1982	Glucose-6-phosphate dehydrogenase (G6PD) activity in hemolysates from control erythrocytes was inhibited 43% by 5.5 mM cytidine 5"-triphosphate (CTP) and 50% by 5.5 mM in uridine 5"-triphosphate (UTP) at pH 7.1.	Cytidine Triphosphate	145-148	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
6795597-1	1981	A cell-free system for the expression of the beta-galactosidase gene was employed to study the effects of the UTP and CTP analogs: s2UTP, s2CTP, f5UTP and rTTP on transcription-translation.	Cytidine Triphosphate	118-121	galactosidase beta 1	Homo sapiens	45-63
6890814-9	1982	Significantly lower levels of GTP + GDP and CTP in 6TG-resistant cells than in parent cells 4 hr after the administration of MTX to tumor-bearing mice may be related to the increased MTX sensitivity of these cells.	Cytidine Triphosphate	44-47	metaxin 1	Mus musculus	125-128
6890814-9	1982	Significantly lower levels of GTP + GDP and CTP in 6TG-resistant cells than in parent cells 4 hr after the administration of MTX to tumor-bearing mice may be related to the increased MTX sensitivity of these cells.	Cytidine Triphosphate	44-47	metaxin 1	Mus musculus	183-186
7426668-5	1980	Although it has been reported that the only effective nucleotide as the phosphoryl donor for hexokinase from various origin in ATP, and that ADP, a reaction product, inhibits the enzyme, hexokinase D from the rainbow-trout liver was found to be able to form glucose 6-phosphate (Glc-6-P) from glucose and various nucleotides such as ATP, ADP, CTP, GTP, UTP and UDP.	Cytidine Triphosphate	343-346	hexokinase 1	Homo sapiens	187-197
6759088-0	1982	[Modification of the catalytic center of Escherichia coli ATP(CTP): tRNA-nucleotidyltransferase by adenosine and cytidine triphosphate derivatives with a reactive group in the triphosphate fragment].	Cytidine Triphosphate	113-134	ATPase	Escherichia coli	58-66
6458284-1	1981	Ecto-ATPase in rat cauda-epididymal intact spermatozoa has a high degree of substrate specificity for the hydrolysis of ATP and dATP rather than of ADP, AMP, GTP, dGTP, CTP, dCTP, TTP and UTP.	Cytidine Triphosphate	169-172	CEA cell adhesion molecule 1	Rattus norvegicus	0-11
6245437-5	1980	The accumulation of UTP and CTP as the results of chronic lead exposure may be explained on the basis of inhibited P5N coupled with the presence of an active nucleoside diphosphokinase.	Cytidine Triphosphate	28-31	cytosolic 5'-nucleotidase 3A	Oryctolagus cuniculus	115-118
65180-8	1977	By use of the ATPase inhibitors DCCD and DPA, or by replacing ATP with GTP, ITP and CTP, a correlation between the ATPase activity and the rate of ATP-dependent membrane energization, as measured by fluorescence quenching, was obtained.	Cytidine Triphosphate	84-87	ATPase	Escherichia coli	115-121
6261809-4	1981	The purified enzyme hydrolyzes triphosphonucleosides (ATP, CTP, GTP, UTP) and diphosphonucleosides (ADP and to a lesser extent CDP, UDP, IDP) and presents pH optima of 6 for ATP and 7 for ADP.	Cytidine Triphosphate	59-62	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	137-140
81070-2	1978	We have measured the rate of transcription of the alpha2u-globulin gene using a nuclear cell-free transcriptional system with mercurated CTP as substrate for the endogenous RNA polymerases.	Cytidine Triphosphate	137-140	alpha2u globulin	Rattus norvegicus	50-66
199433-8	1977	CTP and ethanolaminephosphate partially inhibited the ethanolamine kinase, but not the choline kinase.	Cytidine Triphosphate	0-3	choline kinase alpha	Rattus norvegicus	54-73
6244157-7	1980	ATP and MgATP (dATP was not tested) bind to the enzyme with dissociation constants of 0.122 and 0.132 mM respectively, while AMP (dAMP was not tested), UTP, CTP, ITP and GTP binding could not be detected by the dialysis equilibrium technique used.	Cytidine Triphosphate	157-160	ATPase phospholipid transporting 8A2	Homo sapiens	0-3
551178-4	1979	The anti-45-CTP recognized native hCG and was devoid of cross-reaction with hLH.	Cytidine Triphosphate	12-15	chorionic gonadotropin subunit beta 5	Homo sapiens	34-37
388429-5	1979	The triphosphate conformations are similar, whereas the terminal phosphate of CDP occupies the site of the gamma-phosphate of CTP, thus implying a protein-nucleotide interaction at this site.	Cytidine Triphosphate	126-129	cut like homeobox 1	Homo sapiens	78-81
34614-7	1979	Tryptic digestion is also retarded by some of the feedback inhibitors of glutamine synthetase including CTP, L-alanine, L-serine, L-histidine, and glucosamine 6-phosphate.	Cytidine Triphosphate	104-107	AT695_RS11110	Staphylococcus aureus	73-93
688069-4	1978	The amount of CTP in an extract was estimated by the conversion of [3H]phosphocholine to 3H-labelled CDP-choline.	Cytidine Triphosphate	14-17	cut-like homeobox 1	Rattus norvegicus	101-104
688069-5	1978	Similarly, the concentration of phosphocholine was estimated by the formation of 3H-labelled CDP-choline from 3H-labelled CTP.	Cytidine Triphosphate	122-125	cut-like homeobox 1	Rattus norvegicus	93-96
688069-6	1978	The conversion of CTP and phosphocholine to CDP-choline was 90% when inorganic pyrophosphatase was added to the incubations.	Cytidine Triphosphate	18-21	cut-like homeobox 1	Rattus norvegicus	44-47
688069-7	1978	The formation of CDP-choline was linear between 1 and 10 nmol of CTP or phosphocholine.	Cytidine Triphosphate	65-68	cut-like homeobox 1	Rattus norvegicus	17-20
209024-1	1978	The reaction catalyzed by CTP:phosphocholine cytidylyltransferase in the reverse direction, i.e. the formation of CTP and phosphocholine from CDP-choline and pyrophosphate, is slightly faster than the reaction in the forward direction.	Cytidine Triphosphate	26-29	cut-like homeobox 1	Rattus norvegicus	142-145
21171-4	1977	It was shown that n-alkanes stimulated one of three enzymic steps of lecithin biosynthesis from choline; that is, the formulation of CDP-choline catalyzed by CTP: cholinephosphate cytidyltransferase [EC 2.7.7.15], an enzyme on the microsomal membrane.	Cytidine Triphosphate	158-161	cut-like homeobox 1	Rattus norvegicus	133-136
188465-8	1976	The Km values of ATP and CTP for the Herpes simplex virus Type I enzyme were 30 and 70 muM respectively; whereas those for the Herpes simplex virus Typr II enzyme were 140 and 450 muM.	Cytidine Triphosphate	25-28	latexin	Homo sapiens	87-90
833121-8	1977	The other terminal transferase was present in two chromatographic forms, required an RNA primer, and used UTP and/or CTP as particularly efficient substrates.	Cytidine Triphosphate	117-120	DNA nucleotidylexotransferase	Homo sapiens	10-30
188465-8	1976	The Km values of ATP and CTP for the Herpes simplex virus Type I enzyme were 30 and 70 muM respectively; whereas those for the Herpes simplex virus Typr II enzyme were 140 and 450 muM.	Cytidine Triphosphate	25-28	latexin	Homo sapiens	180-183
1263770-2	1976	The formation of CDP-diglyceride from radioactive phosphatidate showed an absolute requirement for CTP and MgCl2.	Cytidine Triphosphate	99-102	cut-like homeobox 1	Rattus norvegicus	17-20
1263770-3	1976	The newly formed [14C] CDP-diglyceride was characterized by thin layer chromatography (TLC), isotopic labeling from radioactive CTP, and its ability to serve as substrate for the microsomal enzyme, CDP-diglyceride: inositol phosphatidyltransferase.	Cytidine Triphosphate	128-131	cut-like homeobox 1	Rattus norvegicus	23-26
1263770-8	1976	Therefore, under the conditions of study, the microsomal CTP: phosphatidate cytidylyltransferase produces mainly monoenoic and dienoic species of CDP-diglyceride and shows little specificity towards different molecular species of phosphatidic acids.	Cytidine Triphosphate	57-60	cut-like homeobox 1	Rattus norvegicus	146-149
4204-0	1976	Studies on the formation by rat brain preparations of CDP-diglyceride from CTP and phosphatidic acids of varying fatty acid compositions.	Cytidine Triphosphate	75-78	cut-like homeobox 1	Rattus norvegicus	54-57
4204-1	1976	The enzyme, CTP:phosphatidate cytidylyltransferase (EC2.7.7.41) which catalyses formation of CDP-diglyceride from CTP and phosphatidic acid has been studied in rat brain preparations and other tissues.	Cytidine Triphosphate	12-15	cut-like homeobox 1	Rattus norvegicus	93-96
4204-1	1976	The enzyme, CTP:phosphatidate cytidylyltransferase (EC2.7.7.41) which catalyses formation of CDP-diglyceride from CTP and phosphatidic acid has been studied in rat brain preparations and other tissues.	Cytidine Triphosphate	114-117	cut-like homeobox 1	Rattus norvegicus	93-96
16659381-4	1975	Under red light, striking photoactivation of NAD kinase was obtained with ATP and subsequently CTP.In the presence of exogenous Mg(2+), which is required for NAD kinase activity, alpha-nitroso-beta-naphthol, cyanide, and dimethylglyoxime, strongly inhibited the activation by red light without affecting the level of NAD kinase in the dark.Of the divalent cations tested with the KCN-treated phytochrome preparation, only Co(2+) was effective for photoactivation of NAD kinase.	Cytidine Triphosphate	95-98	NAD kinase	Homo sapiens	45-55
239391-1	1975	The interaction of Mg2+ with nucleoside triphosphates: ATP, GTP, CTP and UTP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution.	Cytidine Triphosphate	65-68	mucin 7, secreted	Homo sapiens	19-22
33993494-3	2021	Here we characterize one fc2 suppressor mutation and map it to CYTIDINE TRIPHOSPHATE SYNTHASE TWO (CTPS2), which encodes one of five enzymes in Arabidopsis necessary for de novo cytoplasmic CTP (and dCTP) synthesis.	Cytidine Triphosphate	99-102	ferrochelatase 2	Arabidopsis thaliana	25-28
4279584-0	1974	Participation of cytidine triphosphate in sodium-dependent phosphorylation, transphosphorylation, and hydrolysis: evidence for two hydrolytic sites in sodium ion-plus potassium ion-dependent adenosine triphosphatase.	Cytidine Triphosphate	17-38	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	191-215
238177-3	1975	Phosphorylcholine cytidyltransferase, the enzyme which catalyzes the transfer of phosphorylcholine to cytidine 5"-triphosphate to form CDP-choline, was studied for the first time in human neonatal lung.	Cytidine Triphosphate	102-126	cut like homeobox 1	Homo sapiens	135-138
238177-6	1975	The Km of CTP was 2.0 times 10- minus 3 M, and the Km of phosphorylcholine was 0.25 times 10- minus 3 M. The true Vmax was 10 nmol CDP-choline/mg protein/10 min.	Cytidine Triphosphate	10-13	cut like homeobox 1	Homo sapiens	131-134
4376013-0	1974	CDP-choline reversal of the CMP and CTP inhibition of phosphatidic acid synthesis by rat brain preparations.	Cytidine Triphosphate	36-39	cut-like homeobox 1	Rattus norvegicus	0-3
34022203-2	2021	The rate-limiting enzymes of de novo CTP and GTP synthesis, cytidine triphosphate synthase (CTPS) and inosine monophosphate dehydrogenase (IMPDH), are the most characterized cytoophidium-forming enzymes in mammalian models.	Cytidine Triphosphate	37-40	CTP synthase 1	Homo sapiens	60-90
34022203-2	2021	The rate-limiting enzymes of de novo CTP and GTP synthesis, cytidine triphosphate synthase (CTPS) and inosine monophosphate dehydrogenase (IMPDH), are the most characterized cytoophidium-forming enzymes in mammalian models.	Cytidine Triphosphate	37-40	CTP synthase 1	Homo sapiens	92-96
32919974-8	2021	Liver-related clinical presentation (ascites, esophageal varices and encephalopathy) and laboratory values (EGFR, serum albumin and bilirubin, platelet count) significantly worsened across the CTP-classes(p=.001).	Cytidine Triphosphate	193-196	epidermal growth factor receptor	Homo sapiens	108-112
34056415-11	2021	The C-terminal truncated DDX3X investigated here hydrolyzes only cytidine triphosphate (CTP) in the absence of RNA and CTP, adenosine triphosphate (ATP), and deoxyribose adenosine triphosphate (dATP) in the presence of RNA.	Cytidine Triphosphate	65-86	DEAD-box helicase 3 X-linked	Homo sapiens	25-30
34056415-11	2021	The C-terminal truncated DDX3X investigated here hydrolyzes only cytidine triphosphate (CTP) in the absence of RNA and CTP, adenosine triphosphate (ATP), and deoxyribose adenosine triphosphate (dATP) in the presence of RNA.	Cytidine Triphosphate	88-91	DEAD-box helicase 3 X-linked	Homo sapiens	25-30
34056415-11	2021	The C-terminal truncated DDX3X investigated here hydrolyzes only cytidine triphosphate (CTP) in the absence of RNA and CTP, adenosine triphosphate (ATP), and deoxyribose adenosine triphosphate (dATP) in the presence of RNA.	Cytidine Triphosphate	119-122	DEAD-box helicase 3 X-linked	Homo sapiens	25-30
32919974-8	2021	Liver-related clinical presentation (ascites, esophageal varices and encephalopathy) and laboratory values (EGFR, serum albumin and bilirubin, platelet count) significantly worsened across the CTP-classes(p=.001).	Cytidine Triphosphate	193-196	albumin	Homo sapiens	114-127
33517146-7	2021	While a 12-residue region of the CTP binds strongly to anionic bilayers containing phosphatidylserine lipids, the CTP termini fray from the membrane allowing for accommodation of the RIT1 globular domain at the membrane-water interface.	Cytidine Triphosphate	33-36	Ras like without CAAX 1	Homo sapiens	183-187
33517146-7	2021	While a 12-residue region of the CTP binds strongly to anionic bilayers containing phosphatidylserine lipids, the CTP termini fray from the membrane allowing for accommodation of the RIT1 globular domain at the membrane-water interface.	Cytidine Triphosphate	114-117	Ras like without CAAX 1	Homo sapiens	183-187
33598470-10	2021	For CTP values, we found significant positive associations with IP-10 (q-value = 0.010), IL-6 (q-value = 0.010), IL-1RA (q-value = 0.033), and sICAM-1 (q-value = 0.010).	Cytidine Triphosphate	4-7	C-X-C motif chemokine ligand 10	Homo sapiens	64-69
32691476-0	2021	CTP-CM enhances osteogenic differentiation of hPDLSCs via NF-kappaB pathway.	Cytidine Triphosphate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	58-67
32691476-10	2021	Mechanistically, CTP-CM leads to activation of NF-kappaB signaling pathway.	Cytidine Triphosphate	17-20	nuclear factor kappa B subunit 1	Homo sapiens	47-56
32691476-12	2021	CONCLUSION: CTP-CM can promote the osteogenic differentiation of hPDLSCs via activating NF-kappaB pathway.	Cytidine Triphosphate	12-15	nuclear factor kappa B subunit 1	Homo sapiens	88-97
33212176-16	2021	Then qRT-PCR analysis found that CTP could significantly up-regulate the expression of VEGFA and vWF.	Cytidine Triphosphate	33-36	vascular endothelial growth factor Aa	Danio rerio	87-92
33212176-16	2021	Then qRT-PCR analysis found that CTP could significantly up-regulate the expression of VEGFA and vWF.	Cytidine Triphosphate	33-36	von Willebrand factor	Danio rerio	97-100
33212176-19	2021	After processing, hemostatic activity of CTP has been enhanced by up-regulating the expression of VEGFA and vWF.	Cytidine Triphosphate	41-44	vascular endothelial growth factor Aa	Danio rerio	98-103
33212176-19	2021	After processing, hemostatic activity of CTP has been enhanced by up-regulating the expression of VEGFA and vWF.	Cytidine Triphosphate	41-44	von Willebrand factor	Danio rerio	108-111
33576499-5	2021	CTP synthetase (CTPS) which is the rate-limiting enzyme in the CTP de novo biosynthesis, is essential for nucleic acid synthesis and cellular energy metabolism, and often appears as cytoophidium in many cell types.	Cytidine Triphosphate	0-3	CTP synthase 1	Homo sapiens	16-20
33564769-3	2021	We report here that SARS-CoV-2 exploits cellular CTP synthetase 1 (CTPS1) to promote CTP synthesis and suppress interferon (IFN) induction.	Cytidine Triphosphate	49-52	CTP synthase 1	Homo sapiens	67-72
33564769-3	2021	We report here that SARS-CoV-2 exploits cellular CTP synthetase 1 (CTPS1) to promote CTP synthesis and suppress interferon (IFN) induction.	Cytidine Triphosphate	49-52	interferon alpha 1	Homo sapiens	112-128
33564769-7	2021	Functionally, ORF7b and ORF8 activate CTPS1 to promote de novo CTP synthesis while shutting down IFN induction.	Cytidine Triphosphate	38-41	ORF7b	Severe acute respiratory syndrome coronavirus 2	14-19
33564769-7	2021	Functionally, ORF7b and ORF8 activate CTPS1 to promote de novo CTP synthesis while shutting down IFN induction.	Cytidine Triphosphate	38-41	ORF8 protein	Severe acute respiratory syndrome coronavirus 2	24-28
33564769-7	2021	Functionally, ORF7b and ORF8 activate CTPS1 to promote de novo CTP synthesis while shutting down IFN induction.	Cytidine Triphosphate	38-41	interferon alpha 1	Homo sapiens	97-100
33564769-8	2021	De novo synthesis of small-molecule inhibitors of CTPS1 enabled CTP depletion and IFN induction in SARS-CoV-2 infection, thus impeding SARS-CoV-2 replication.	Cytidine Triphosphate	50-53	interferon alpha 1	Homo sapiens	82-85
33598470-10	2021	For CTP values, we found significant positive associations with IP-10 (q-value = 0.010), IL-6 (q-value = 0.010), IL-1RA (q-value = 0.033), and sICAM-1 (q-value = 0.010).	Cytidine Triphosphate	4-7	interleukin 6	Homo sapiens	89-93
33598470-10	2021	For CTP values, we found significant positive associations with IP-10 (q-value = 0.010), IL-6 (q-value = 0.010), IL-1RA (q-value = 0.033), and sICAM-1 (q-value = 0.010).	Cytidine Triphosphate	4-7	interleukin 1 receptor antagonist	Homo sapiens	113-119
33317256-9	2021	ALC patients had higher CTP (10.6+-2.0 vs. 9.0+-2.3) and MELD scores (21.49+-8.47 vs. 16.85+-7.79) and higher mortality (42.3% vs 27.3%,p<0.001) compared to non-ALC.	Cytidine Triphosphate	24-27	allantoicase	Homo sapiens	0-3
33383878-10	2020	Conclusion: Data in this study indicated that the changes of epigenetic molecules including DNMT1, DNMT3a, DNMT3b, HDAC1, and let-7a occurred at the early stages of BEAS-2B cell malignant transformation after CTPE exposure, which provided critical information for screening early biomarkers of CTP-associated occupational lung cancer.	Cytidine Triphosphate	209-212	DNA methyltransferase 1	Homo sapiens	92-97
32156537-7	2020	CTP effectively regulated the levels of hematopoiesis-related cytokines, such as granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), interleukin 2, and interferons-gamma, and enhanced the expression of hematopoiesis-related proteins in both primary bone marrow cells and mice with hematopoietic dysfunction.	Cytidine Triphosphate	0-3	colony stimulating factor 3 (granulocyte)	Mus musculus	81-118
33329332-6	2020	For posterior fossa strokes, comprehensive CTP analysis had an AUC of 0.68 vs. 0.62 for automated core-penumbra maps and 0.55 for NCCT.	Cytidine Triphosphate	43-46	solute carrier family 12 member 3	Homo sapiens	130-134
33108121-5	2020	This unique role explains why evolution has led to the early emergence in animals of an antiviral immunity enzyme, viperin, that synthesizes a toxic analogue of CTP.	Cytidine Triphosphate	161-164	radical S-adenosyl methionine domain containing 2	Homo sapiens	115-122
32603630-4	2020	Most recently, however, viperin was demonstrated to catalyze the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously unknown ribonucleotide.	Cytidine Triphosphate	79-100	radical S-adenosyl methionine domain containing 2	Homo sapiens	24-31
32603630-4	2020	Most recently, however, viperin was demonstrated to catalyze the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously unknown ribonucleotide.	Cytidine Triphosphate	102-105	radical S-adenosyl methionine domain containing 2	Homo sapiens	24-31
32984091-3	2020	Serum insulin-like growth factor-1 (IGF-1)-CTP has been proposed to improve CTP prognostic accuracy.	Cytidine Triphosphate	43-46	insulin like growth factor 1	Homo sapiens	6-34
32984091-3	2020	Serum insulin-like growth factor-1 (IGF-1)-CTP has been proposed to improve CTP prognostic accuracy.	Cytidine Triphosphate	43-46	insulin like growth factor 1	Homo sapiens	36-41
32984091-3	2020	Serum insulin-like growth factor-1 (IGF-1)-CTP has been proposed to improve CTP prognostic accuracy.	Cytidine Triphosphate	76-79	insulin like growth factor 1	Homo sapiens	6-34
32984091-3	2020	Serum insulin-like growth factor-1 (IGF-1)-CTP has been proposed to improve CTP prognostic accuracy.	Cytidine Triphosphate	76-79	insulin like growth factor 1	Homo sapiens	36-41
33040516-4	2020	CTP, the shortest isoform of cochlin encoded by the COCH gene, has been proven to be a perilymph-specific protein which is not expressed in blood, cerebrospinal fluid and saliva but is highly expressed in lymphatic fluid of the inner ear and is used as a diagnostic biochemical marker for perilymph fistula.	Cytidine Triphosphate	0-3	cochlin	Homo sapiens	29-36
33040516-4	2020	CTP, the shortest isoform of cochlin encoded by the COCH gene, has been proven to be a perilymph-specific protein which is not expressed in blood, cerebrospinal fluid and saliva but is highly expressed in lymphatic fluid of the inner ear and is used as a diagnostic biochemical marker for perilymph fistula.	Cytidine Triphosphate	0-3	cochlin	Homo sapiens	52-56
32874736-14	2020	Conclusion: CTP in the vasospastic period may be an indication for ET and predict the effectiveness of ET for CV to improve clinical outcomes.	Cytidine Triphosphate	12-15	major facilitator superfamily domain containing 11	Homo sapiens	67-69
32874736-14	2020	Conclusion: CTP in the vasospastic period may be an indication for ET and predict the effectiveness of ET for CV to improve clinical outcomes.	Cytidine Triphosphate	12-15	major facilitator superfamily domain containing 11	Homo sapiens	103-105
32156537-7	2020	CTP effectively regulated the levels of hematopoiesis-related cytokines, such as granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), interleukin 2, and interferons-gamma, and enhanced the expression of hematopoiesis-related proteins in both primary bone marrow cells and mice with hematopoietic dysfunction.	Cytidine Triphosphate	0-3	colony stimulating factor 3 (granulocyte)	Mus musculus	120-125
32156537-7	2020	CTP effectively regulated the levels of hematopoiesis-related cytokines, such as granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), interleukin 2, and interferons-gamma, and enhanced the expression of hematopoiesis-related proteins in both primary bone marrow cells and mice with hematopoietic dysfunction.	Cytidine Triphosphate	0-3	colony stimulating factor 1 (macrophage)	Mus musculus	128-164
32156537-7	2020	CTP effectively regulated the levels of hematopoiesis-related cytokines, such as granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), interleukin 2, and interferons-gamma, and enhanced the expression of hematopoiesis-related proteins in both primary bone marrow cells and mice with hematopoietic dysfunction.	Cytidine Triphosphate	0-3	colony stimulating factor 1 (macrophage)	Mus musculus	166-171
32156537-7	2020	CTP effectively regulated the levels of hematopoiesis-related cytokines, such as granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), interleukin 2, and interferons-gamma, and enhanced the expression of hematopoiesis-related proteins in both primary bone marrow cells and mice with hematopoietic dysfunction.	Cytidine Triphosphate	0-3	interleukin 2	Mus musculus	174-187
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	83-104	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71
32592107-12	2020	Future in vivo studies of the nuclear role of JPH2-CTP may reveal a causal association with adverse remodeling during HF and establish CTP as a therapeutic target.	Cytidine Triphosphate	51-54	junctophilin 2	Rattus norvegicus	46-50
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	106-109	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	152-155	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71
32061099-2	2020	Recently, it has been reported that the radical-SAM activity of viperin transforms cytidine triphosphate (CTP) to its analogue 3"-deoxy-3",4"-didehydro-CTP (ddhCTP).	Cytidine Triphosphate	152-155	radical S-adenosyl methionine domain containing 2	Homo sapiens	64-71
31720820-10	2020	CONCLUSIONS: rTPA in WUS patients selected with CT and/or CTP resulted in reduced ischemic infarct volume on follow-up CT and better functional outcome without increment of intracranial hemorrhages and in-hospital mortality.	Cytidine Triphosphate	58-61	plasminogen activator, tissue type	Rattus norvegicus	13-17
32202359-3	2020	Results showed that the calcined tooth powder (CTP) and silver nanoparticles (AgNPs) additives could induce the PDLSCs into odontogenesis differentiation; besides, the immunofluorescence staining identified that the high dosage calcined tooth powder (400 mug/mL) significantly facilitated the odontogenesis associated with BMP4 expression.	Cytidine Triphosphate	47-50	bone morphogenetic protein 4	Canis lupus familiaris	323-327
32268567-9	2020	Oral administration of GOS and CTP significantly lowered the tissue cytokine (interleukin-6 and -12, and tumor necrosis factor-alpha) levels.	Cytidine Triphosphate	31-34	interleukin 6	Mus musculus	78-99
32268567-9	2020	Oral administration of GOS and CTP significantly lowered the tissue cytokine (interleukin-6 and -12, and tumor necrosis factor-alpha) levels.	Cytidine Triphosphate	31-34	tumor necrosis factor	Mus musculus	105-132
32232843-2	2020	Recently, it was found that RSAD2 catalyses transformation of cytidine triphosphate (CTP) to its analogue 3 -deoxy-3 ,4 -didehydro-CTP (ddhCTP).	Cytidine Triphosphate	62-83	radical S-adenosyl methionine domain containing 2	Homo sapiens	28-33
32232843-2	2020	Recently, it was found that RSAD2 catalyses transformation of cytidine triphosphate (CTP) to its analogue 3 -deoxy-3 ,4 -didehydro-CTP (ddhCTP).	Cytidine Triphosphate	85-88	radical S-adenosyl methionine domain containing 2	Homo sapiens	28-33
31954130-3	2020	DCTPP1 also exhibits an additional "house cleaning" function as it has been shown to be highly active against modified cytidine triphosphates, such as 5-methyl-dCTP, which, if incorrectly incorporated into DNA can introduce undesirable epigenetic marking.	Cytidine Triphosphate	119-141	dCTP pyrophosphatase 1	Homo sapiens	0-6
31917549-1	2020	Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3"-deoxy-3",4"-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains.	Cytidine Triphosphate	101-122	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
31917549-1	2020	Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3"-deoxy-3",4"-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains.	Cytidine Triphosphate	124-127	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
31917549-2	2020	Here, we describe crystal structures of viperin bound to a SAM analogue and CTP or uridine triphosphate (UTP) and report kinetic parameters for viperin-catalyzed reactions with CTP or UTP as substrates.	Cytidine Triphosphate	76-79	radical S-adenosyl methionine domain containing 2	Homo sapiens	40-47
31917549-2	2020	Here, we describe crystal structures of viperin bound to a SAM analogue and CTP or uridine triphosphate (UTP) and report kinetic parameters for viperin-catalyzed reactions with CTP or UTP as substrates.	Cytidine Triphosphate	177-180	radical S-adenosyl methionine domain containing 2	Homo sapiens	40-47
31917549-2	2020	Here, we describe crystal structures of viperin bound to a SAM analogue and CTP or uridine triphosphate (UTP) and report kinetic parameters for viperin-catalyzed reactions with CTP or UTP as substrates.	Cytidine Triphosphate	177-180	radical S-adenosyl methionine domain containing 2	Homo sapiens	144-151
31917549-3	2020	Viperin orients the C4" hydrogen atom of CTP and UTP similarly for abstraction by a 5"-deoxyadenosyl radical, but the uracil moiety introduces unfavorable interactions that prevent tight binding of UTP.	Cytidine Triphosphate	41-44	radical S-adenosyl methionine domain containing 2	Homo sapiens	0-7
30985989-2	2019	Based on the results of high-throughput screening of a library of bioactive compounds and neurotransmitters, we report here that the four nucleoside triphosphates ATP, GTP, CTP and UTP inhibit the SH2 domain of the tumor-related transcription factor STAT5b.	Cytidine Triphosphate	173-176	signal transducer and activator of transcription 5B	Homo sapiens	250-256
32727257-9	2020	In HL-60-R, the triple combination retinoic acid, DMSO and DAC increased all NTPs almost 2-fold in contrast to HL60-S. Uridine increased UTP (1.4-fold), CTP (2-fold) and dCTP (1.4.-fold) pools in both cell lines, but thymidine increased only dTTP pools (4- to 7-fold), with a depletion of dCTP.	Cytidine Triphosphate	153-156	arylacetamide deacetylase	Homo sapiens	59-62
32422636-9	2020	In correlation analysis, there were inverse correlation between mean cTp-e interval and CD4 count and Tp-e/QTc ratios and CD4 count (r = - 0.407, p <0.001, r = - 0.416, p <0.001, respectively).	Cytidine Triphosphate	69-72	CD4 molecule	Homo sapiens	88-91
31524312-1	2019	Cytidine 5"-triphosphate synthetase (CTPS) is known to be a central enzyme in the de novo synthesis of CTP.	Cytidine Triphosphate	37-40	CTP synthase 1	Homo sapiens	0-35
31125665-1	2019	Cytidine/uridine monophosphate kinase 2 (CMPK2) is known as a nucleoside monophosphate kinase in mitochondria to maintains intracellular UTP/CTP, and could be induced by immunostimulants LPS and Poly (I:C) in mammals, suggesting its potential antiviral and antibacterial role.	Cytidine Triphosphate	141-144	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-39
31125665-1	2019	Cytidine/uridine monophosphate kinase 2 (CMPK2) is known as a nucleoside monophosphate kinase in mitochondria to maintains intracellular UTP/CTP, and could be induced by immunostimulants LPS and Poly (I:C) in mammals, suggesting its potential antiviral and antibacterial role.	Cytidine Triphosphate	141-144	cytidine/uridine monophosphate kinase 2	Homo sapiens	41-46
30676677-8	2019	Furthermore, we demonstrated that hCG supplementation had no negative effects in embryo cryosurvival and development, showing similar survival rate at birth than FSH-CTP alone group.	Cytidine Triphosphate	166-169	chorionic gonadotropin subunit beta 5	Homo sapiens	34-37
31347545-12	2019	Compared to those without RLS, patient with RLS had a lower MELD score (9 [6-25] versus 11 [6-41], P = 0.04), and a comparable distribution of CTP classes and frequency of decompensated liver disease.	Cytidine Triphosphate	143-146	RLS1	Homo sapiens	44-47
31165204-8	2019	PLAC1 may be regarded as a potential CTP antigen for targeted cancer immunotherapy based on the available data on its promoting function in cancer development and also its expression in cancers of different histological origin.	Cytidine Triphosphate	37-40	placenta enriched 1	Homo sapiens	0-5
30280591-7	2019	In our case, a prolonged phase of SEP amplitude instability during vasospasm in SAH correlated with a phase of ischemic penumbra, as demonstrated by CTP.	Cytidine Triphosphate	149-152	plexin B1	Homo sapiens	34-37
30872404-7	2019	We show that IRAK1 and TRAF6 increase viperin activity ~10-fold to efficiently catalyze the radical-mediated dehydration of CTP to ddhCTP.	Cytidine Triphosphate	124-127	interleukin 1 receptor associated kinase 1	Homo sapiens	13-18
30872404-7	2019	We show that IRAK1 and TRAF6 increase viperin activity ~10-fold to efficiently catalyze the radical-mediated dehydration of CTP to ddhCTP.	Cytidine Triphosphate	124-127	TNF receptor associated factor 6	Homo sapiens	23-28
30872404-7	2019	We show that IRAK1 and TRAF6 increase viperin activity ~10-fold to efficiently catalyze the radical-mediated dehydration of CTP to ddhCTP.	Cytidine Triphosphate	124-127	radical S-adenosyl methionine domain containing 2	Homo sapiens	38-45
31015840-3	2019	First, ALP activity assay determined that 200 mug/mL was the optimal concentration of CTP-CM for the following experiments.	Cytidine Triphosphate	86-89	ATHS	Homo sapiens	7-10
30768932-1	2019	CTP synthase (CTPsyn) is a metabolic enzyme essential for the de novo synthesis of CTP the nucleotide.	Cytidine Triphosphate	0-3	CTP synthase	Drosophila melanogaster	14-20
31015833-11	2019	In conclusion, our findings support CTP as the optimum neoadjuvant regimen for HER2-positive breast cancer, with the best pCR and acceptable toxicity compared with CT. MP provides a therapeutic option for patients with poor performance status.	Cytidine Triphosphate	36-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
30824840-4	2019	Patients with CTP class A had a significantly lower proportion of detectable IL-4 or IL-6, but a higher proportion of detectable IL-22 than patients with CTP class B/C.	Cytidine Triphosphate	14-17	interleukin 4	Homo sapiens	77-81
30824840-4	2019	Patients with CTP class A had a significantly lower proportion of detectable IL-4 or IL-6, but a higher proportion of detectable IL-22 than patients with CTP class B/C.	Cytidine Triphosphate	14-17	interleukin 6	Homo sapiens	85-89
30824840-4	2019	Patients with CTP class A had a significantly lower proportion of detectable IL-4 or IL-6, but a higher proportion of detectable IL-22 than patients with CTP class B/C.	Cytidine Triphosphate	14-17	interleukin 22	Homo sapiens	129-134
30653991-4	2019	Our enzymatic assays suggest that Cab2 could utilize both ATP and CTP to activate PPA in vitro.	Cytidine Triphosphate	66-69	phosphopantothenate--cysteine ligase CAB2	Saccharomyces cerevisiae S288C	34-38
30462540-6	2019	Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis.	Cytidine Triphosphate	24-27	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-73
30462540-6	2019	Decreased expression of CTP: phosphocholine cytidylyltransferase (CCTbeta), a rate-limiting enzyme for phosphatidylcholine (PC) synthesis, is similarly able to inhibit MCE and PC synthesis; however, the decreased GDE5 expression resulted in accumulation of intracellular GPC but did not affect PC synthesis.	Cytidine Triphosphate	24-27	glycerophosphocholine phosphodiesterase 1	Homo sapiens	213-217
30857853-1	2019	CTP synthase (CTPS), the rate-limiting enzyme in de novo CTP biosynthesis, has been demonstrated to assemble into evolutionarily conserved filamentous structures, termed cytoophidia, in Drosophila, bacteria, yeast and mammalian cells.	Cytidine Triphosphate	0-3	CTP synthase	Drosophila melanogaster	14-18
30949314-10	2019	Child Turcotte Pugh (CTP) Class (A 9/55, B 15/68, C 17/34; p 0.043) and alcohol as etiology for liver dysfunction (p 0.03) were significantly associated with RLS.	Cytidine Triphosphate	21-24	RLS1	Homo sapiens	158-161
30537333-9	2019	Regression modelling of duration of lag phase and doubling time by cell marker suggests the presence of CD90 and CD105 in CTP subpopulations with different proliferative capabilities.	Cytidine Triphosphate	122-125	Thy-1 cell surface antigen	Homo sapiens	104-108
30661271-11	2019	Further, CTP-EGF treatment led to increased expression of HAS3 enzyme and subsequently boosted hyaluronic acid synthesis.	Cytidine Triphosphate	9-12	hyaluronan synthase 3	Homo sapiens	58-62
30653991-5	2019	The results of isothermal titration calorimetry indicate that PPA, CTP, and ATP could bind to Cab2 individually, with PPA having the highest binding affinity.	Cytidine Triphosphate	67-70	phosphopantothenate--cysteine ligase CAB2	Saccharomyces cerevisiae S288C	94-98
30374460-4	2018	Patients with no increase in CTP score had lower pretreatment plasma HGF level (p = 0.015).	Cytidine Triphosphate	29-32	hepatocyte growth factor	Homo sapiens	69-72
30419181-11	2018	Furthermore, evaluation of these CTP subsets in BM revealed that CD271+CD56+ cells were localized in the bone-lining regions whereas CD271+CD56- cells were found in the perivascular regions.	Cytidine Triphosphate	33-36	nerve growth factor receptor	Homo sapiens	65-70
30419181-11	2018	Furthermore, evaluation of these CTP subsets in BM revealed that CD271+CD56+ cells were localized in the bone-lining regions whereas CD271+CD56- cells were found in the perivascular regions.	Cytidine Triphosphate	33-36	neural cell adhesion molecule 1	Homo sapiens	71-75
30322618-9	2018	Our results showed that CTP upregulated collagen genes via the p38 mitogen-activated protein kinase (MAPK)/SKN-1 pathway.	Cytidine Triphosphate	24-27	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	107-112
30322618-10	2018	Moreover, CTP extended lifespan and delayed aging through p38 MAPK/SKN-1 pathway.	Cytidine Triphosphate	10-13	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	67-72
30236599-5	2018	CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARalpha), and peroxisome proliferator-activated receptor gamma (PPARgamma).	Cytidine Triphosphate	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	153-157
30236599-5	2018	CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARalpha), and peroxisome proliferator-activated receptor gamma (PPARgamma).	Cytidine Triphosphate	0-3	peroxisome proliferator activated receptor alpha	Mus musculus	160-208
30236599-5	2018	CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARalpha), and peroxisome proliferator-activated receptor gamma (PPARgamma).	Cytidine Triphosphate	0-3	peroxisome proliferator activated receptor alpha	Mus musculus	210-219
30236599-5	2018	CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARalpha), and peroxisome proliferator-activated receptor gamma (PPARgamma).	Cytidine Triphosphate	0-3	peroxisome proliferator activated receptor gamma	Mus musculus	226-274
30236599-5	2018	CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARalpha), and peroxisome proliferator-activated receptor gamma (PPARgamma).	Cytidine Triphosphate	0-3	peroxisome proliferator activated receptor gamma	Mus musculus	276-285
30236599-6	2018	In conclusion, results suggested that CTP protected against D-GalN/LPS -induced acute liver injury by up-regulation of Nrf2, PPARalpha, and PPARgamma.	Cytidine Triphosphate	38-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
30236599-6	2018	In conclusion, results suggested that CTP protected against D-GalN/LPS -induced acute liver injury by up-regulation of Nrf2, PPARalpha, and PPARgamma.	Cytidine Triphosphate	38-41	peroxisome proliferator activated receptor alpha	Mus musculus	125-134
30236599-6	2018	In conclusion, results suggested that CTP protected against D-GalN/LPS -induced acute liver injury by up-regulation of Nrf2, PPARalpha, and PPARgamma.	Cytidine Triphosphate	38-41	peroxisome proliferator activated receptor gamma	Mus musculus	140-149
30250037-3	2018	Herein, we provide experimental and computational evidence of structurally characterized square planar eta2-Ni(0)-thiophene species and their relevance to the mechanism of CTP.	Cytidine Triphosphate	172-175	DNA polymerase iota	Homo sapiens	103-107
30441852-10	2018	TriCEPs experiments revealed five candidate binding partners for CTP, with Kcnh5 being felt to be the most likely candidate as it showed a trend towards being competed out by siRNA knockdown.	Cytidine Triphosphate	65-68	potassium voltage-gated channel subfamily H member 5	Homo sapiens	75-80
30236599-5	2018	CTP also increased levels of glutathione in D-GalN/LPS -induced acute liver injury mice by up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor alpha (PPARalpha), and peroxisome proliferator-activated receptor gamma (PPARgamma).	Cytidine Triphosphate	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-151
30285320-1	2018	CTP synthase (CTPS) and IMP dehydrogenase (IMPDH) catalyse the rate-limiting steps of de novo CTP and guanosine nucleotide biosynthesis, respectively, and form filament assemblies in response to inhibitors.	Cytidine Triphosphate	0-3	CTP synthase 1	Homo sapiens	14-18
30250037-4	2018	These results confirm the viability of C,C-eta2 bound intermediates in CTP of thiophenes, providing an electronic rationale for the stability of such species, and thus that such processes can proceed as living polymerizations.	Cytidine Triphosphate	71-74	DNA polymerase iota	Homo sapiens	43-47
29072835-4	2018	Further work has revealed that MMV008138 targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, which converts MEP and cytidine triphosphate (CTP) to cytidinediphosphate methylerythritol (CDP-ME) and pyrophosphate.	Cytidine Triphosphate	168-189	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	119-123
29577605-14	2018	When both FVIII and PC levels were normalized, the ETP decreased from 929 nm min to 340 nm min (CTP-A), 1122 nm min to 506 nm min (CTP-B), and 1226 nm min to 586 nm min (CTP-C), becoming similar to control levels.	Cytidine Triphosphate	96-99	coagulation factor VIII	Homo sapiens	10-15
29727439-10	2018	In the non-brain-dead group, CTP results revealed CBF 2.37-37.59 mL/100 g/min and CBV 0.73-2.34 mL/100 g. The difference between values of CBF and CBV in the brain-dead and non-brain-dead groups was statistically significant (p=0.002 for CBF and p=0.001 for CBV).	Cytidine Triphosphate	29-32	CCAAT enhancer binding protein zeta	Homo sapiens	50-55
29987902-8	2018	We found that ENTPD8 had a gene-metabolite association with cytidine in the CTP dephosphorylation pathway.	Cytidine Triphosphate	76-79	ectonucleoside triphosphate diphosphohydrolase 8	Homo sapiens	14-20
29987902-10	2018	ENTPD8 was downregulated in PCT, causing a reduction in cytidine formation and hence weakened CTP dephosphorylation in pyrimidine metabolism.	Cytidine Triphosphate	94-97	ectonucleoside triphosphate diphosphohydrolase 8	Homo sapiens	0-6
30060630-12	2018	CTP treatment also downregulated the expression of PPAR-gamma and C/EBP-alpha, adipogenic differentiation markers in hASCs, compared to the adipogenic differentiation group.	Cytidine Triphosphate	0-3	peroxisome proliferator activated receptor gamma	Homo sapiens	51-61
30060630-12	2018	CTP treatment also downregulated the expression of PPAR-gamma and C/EBP-alpha, adipogenic differentiation markers in hASCs, compared to the adipogenic differentiation group.	Cytidine Triphosphate	0-3	CCAAT enhancer binding protein alpha	Homo sapiens	66-77
30060630-13	2018	The expression of FAS and SREBP-1 decreased in the CTP group, along with the fluorescent intensity (amount) of ROS.	Cytidine Triphosphate	51-54	sterol regulatory element binding transcription factor 1	Homo sapiens	26-33
30060630-15	2018	Meanwhile, in both the NHDC and CTP groups, Nrf2 expression was restored to the level of the control group.	Cytidine Triphosphate	32-35	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
30060630-16	2018	Moreover, the expression of HO-1 and NQO-1 increased significantly in the CTP group.	Cytidine Triphosphate	74-77	heme oxygenase 1	Homo sapiens	28-32
30060630-16	2018	Moreover, the expression of HO-1 and NQO-1 increased significantly in the CTP group.	Cytidine Triphosphate	74-77	NAD(P)H quinone dehydrogenase 1	Homo sapiens	37-42
30060630-17	2018	Taken together, these results suggest that CTP treatment suppresses the adipogenic differentiation of hASCs by decreasing intracellular ROS, possibly through activation of the Nrf2 cytoprotective pathway.	Cytidine Triphosphate	43-46	NFE2 like bZIP transcription factor 2	Homo sapiens	176-180
30060630-18	2018	Thus, the use of bioactive substances such as CTP, which activates Nrf2 to reduce the cellular level of ROS and inhibit the adipogenic differentiation of hASCs, could be a new strategy for overcoming obesity.	Cytidine Triphosphate	46-49	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
30018106-4	2018	One bacterial CTP is the CtpA protease of Pseudomonas aeruginosa, which is required for type III secretion system (T3SS) function and for virulence in a mouse model of acute pneumonia.	Cytidine Triphosphate	14-17	CTPP	Homo sapiens	25-29
30018106-13	2018	Pseudomonas aeruginosa is an important human pathogen in which one CTP, known as CtpA, is required for type III secretion system function and for virulence.	Cytidine Triphosphate	67-70	CTPP	Homo sapiens	81-85
29240251-13	2018	The pathological changes affect CTP-Cs in Csp and Cdp cartilage zones differently.	Cytidine Triphosphate	32-35	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	42-45
29240251-13	2018	The pathological changes affect CTP-Cs in Csp and Cdp cartilage zones differently.	Cytidine Triphosphate	32-35	cut like homeobox 1	Homo sapiens	50-53
29925952-4	2018	Here we demonstrate that viperin catalyses the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously undescribed biologically relevant molecule, via a SAM-dependent radical mechanism.	Cytidine Triphosphate	61-82	radical S-adenosyl methionine domain containing 2	Homo sapiens	25-32
29925952-4	2018	Here we demonstrate that viperin catalyses the conversion of cytidine triphosphate (CTP) to 3"-deoxy-3",4"-didehydro-CTP (ddhCTP), a previously undescribed biologically relevant molecule, via a SAM-dependent radical mechanism.	Cytidine Triphosphate	84-87	radical S-adenosyl methionine domain containing 2	Homo sapiens	25-32
29072835-4	2018	Further work has revealed that MMV008138 targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, which converts MEP and cytidine triphosphate (CTP) to cytidinediphosphate methylerythritol (CDP-ME) and pyrophosphate.	Cytidine Triphosphate	191-194	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	119-123
28975414-1	2018	De novo synthesis of the nucleotide CTP is catalyzed by the essential pyrimidine biosynthesis enzyme CTP synthase (CTPs), which forms large-scale filamentous structures consisting of CTPs termed cytoophidia in prokaryotes and in eukaryotes.	Cytidine Triphosphate	36-39	CTP synthase 1	Homo sapiens	101-113
29621543-4	2018	Exosomes expressing cardiac-targeting peptide (CTP)-Lamp2b on the exosomal membrane (CTP-Exo) were generated by introducing vectors encoding CTP-Lamp2b into HEK 293 cells.	Cytidine Triphosphate	47-50	5'-3' exoribonuclease 1	Mus musculus	0-3
29621543-4	2018	Exosomes expressing cardiac-targeting peptide (CTP)-Lamp2b on the exosomal membrane (CTP-Exo) were generated by introducing vectors encoding CTP-Lamp2b into HEK 293 cells.	Cytidine Triphosphate	85-88	5'-3' exoribonuclease 1	Mus musculus	0-3
29621543-7	2018	The in vitro and in vivo uptake of CTL-Exo and CTP-Exo was evaluated in cell lines and mice.	Cytidine Triphosphate	47-50	5'-3' exoribonuclease 1	Mus musculus	51-54
29621543-10	2018	Cell viability was maintained at almost 100% with different dosages of both CTL-Exo and CTP-Exo.	Cytidine Triphosphate	88-91	5'-3' exoribonuclease 1	Mus musculus	92-95
29621543-11	2018	Moreover, compared with CTL-Exo, the in vivo delivery of exosomes to the hearts of mice was increased by 15% with CTP-Exo (P = 0.035).	Cytidine Triphosphate	114-117	5'-3' exoribonuclease 1	Mus musculus	118-121
29621543-14	2018	These results suggested that CTP-Exo might be used as a therapeutic tool for heart disease.	Cytidine Triphosphate	29-32	5'-3' exoribonuclease 1	Mus musculus	33-36
29178478-4	2018	In this pathway, choline is converted to phosphocholine by choline kinase, phosphocholine is metabolized to CDP-choline by the rate-determining enzyme for this pathway, CTP:phosphocholine cytidylyltransferase, and cholinephosphotransferase condenses CDP-choline with diacylglycerol to produce PC.	Cytidine Triphosphate	169-172	cut like homeobox 1	Homo sapiens	108-111
29178478-4	2018	In this pathway, choline is converted to phosphocholine by choline kinase, phosphocholine is metabolized to CDP-choline by the rate-determining enzyme for this pathway, CTP:phosphocholine cytidylyltransferase, and cholinephosphotransferase condenses CDP-choline with diacylglycerol to produce PC.	Cytidine Triphosphate	169-172	cut like homeobox 1	Homo sapiens	250-253
29552149-2	2018	In order to investigate the function of the anti-oxidative signaling pathway regulated by NF-E2-related factor 2 (Nrf2) during cancer development, BEAS-2B cells were cultured with CTP extract for 30 passages.	Cytidine Triphosphate	180-183	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
29552149-4	2018	The expression levels of Nrf2 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were promoted throughout the CTP exposure culture, and there was a positive linear correlation between the expression levels of Nrf2 and NQO1.	Cytidine Triphosphate	103-106	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
29552149-4	2018	The expression levels of Nrf2 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were promoted throughout the CTP exposure culture, and there was a positive linear correlation between the expression levels of Nrf2 and NQO1.	Cytidine Triphosphate	103-106	NAD(P)H quinone dehydrogenase 1	Homo sapiens	34-66
29552149-4	2018	The expression levels of Nrf2 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were promoted throughout the CTP exposure culture, and there was a positive linear correlation between the expression levels of Nrf2 and NQO1.	Cytidine Triphosphate	103-106	NAD(P)H quinone dehydrogenase 1	Homo sapiens	68-72
29552149-4	2018	The expression levels of Nrf2 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were promoted throughout the CTP exposure culture, and there was a positive linear correlation between the expression levels of Nrf2 and NQO1.	Cytidine Triphosphate	103-106	NFE2 like bZIP transcription factor 2	Homo sapiens	202-206
29552149-4	2018	The expression levels of Nrf2 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were promoted throughout the CTP exposure culture, and there was a positive linear correlation between the expression levels of Nrf2 and NQO1.	Cytidine Triphosphate	103-106	NAD(P)H quinone dehydrogenase 1	Homo sapiens	211-215
29552149-8	2018	Thus, Nrf2 was associated with the malignant transformation of BEAS-2B cells exposed to CTP and may be a potential therapeutic target.	Cytidine Triphosphate	88-91	NFE2 like bZIP transcription factor 2	Homo sapiens	6-10
28600481-8	2018	Relative CTP parameters were as follows: rCBF, 0.62 (0.81); rCBV, 0.83 (0.87); and rMTT, 1.61 (0.73).	Cytidine Triphosphate	9-12	CCAAT/enhancer binding protein zeta	Rattus norvegicus	41-45
29427663-2	2018	Activation of naive CD4 T cells with synthetic intracellular agonists dTAT-WKYMVm and CTP-WKYMVm for FPR members stimulated CD4 T cell migration via pertussis toxin-sensitive manner.	Cytidine Triphosphate	86-89	CD4 molecule	Homo sapiens	20-23
29427663-2	2018	Activation of naive CD4 T cells with synthetic intracellular agonists dTAT-WKYMVm and CTP-WKYMVm for FPR members stimulated CD4 T cell migration via pertussis toxin-sensitive manner.	Cytidine Triphosphate	86-89	CD4 molecule	Homo sapiens	124-127
29340620-4	2018	We have previously verified that fusion protein CTP-HBcAg18-27-Tapasin could facilitate the maturation of bone marrow derived dendritic cells and enhance specific CTLs responses in vitro, which might be associated with the activation of JAK/STAT signaling pathway.	Cytidine Triphosphate	48-51	TAP binding protein	Homo sapiens	63-70
29340620-5	2018	To further explore whether JAK/STAT signaling pathway participated in specific immune responses mediated by CTP-HBcAg18-27-Tapasin, we suppressed the JAK/STAT pathway with pharmacological inhibitor (AG490) in vivo.	Cytidine Triphosphate	108-111	TAP binding protein	Homo sapiens	123-130
29340620-11	2018	These results demonstrate that the JAK/STAT signaling pathway participates in Th1-oriented immune response induced by CTP-HBcAg18-27-Tapasin and this might provide a theoretical basis for HBV immunotherapy.	Cytidine Triphosphate	118-121	negative elongation factor complex member C/D	Homo sapiens	78-81
29340620-11	2018	These results demonstrate that the JAK/STAT signaling pathway participates in Th1-oriented immune response induced by CTP-HBcAg18-27-Tapasin and this might provide a theoretical basis for HBV immunotherapy.	Cytidine Triphosphate	118-121	TAP binding protein	Homo sapiens	133-140
28975414-1	2018	De novo synthesis of the nucleotide CTP is catalyzed by the essential pyrimidine biosynthesis enzyme CTP synthase (CTPs), which forms large-scale filamentous structures consisting of CTPs termed cytoophidia in prokaryotes and in eukaryotes.	Cytidine Triphosphate	36-39	CTP synthase 1	Homo sapiens	115-119
28975414-1	2018	De novo synthesis of the nucleotide CTP is catalyzed by the essential pyrimidine biosynthesis enzyme CTP synthase (CTPs), which forms large-scale filamentous structures consisting of CTPs termed cytoophidia in prokaryotes and in eukaryotes.	Cytidine Triphosphate	36-39	CTP synthase 1	Homo sapiens	183-187
28655658-3	2017	For this purpose, a breast cancer-specific cell targeting peptide (CTP) was incorporated into our leading peptide-based gene delivery system (to generate DEN-K(GALA)-TAT-K(STR)-CTP) to improve its cell-specific internalization, and investigated in combination with a formulation approach (DOPE/1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)).	Cytidine Triphosphate	67-70	galactosidase alpha	Homo sapiens	160-164
28840583-8	2017	Child-Turcotte-Pugh (CTP) and Model for End-Stage Liver Disease (MELD), disease severity scores improved in patients treated with G-CSF, with significant difference only for the CTP score at 90 days follow-up.	Cytidine Triphosphate	21-24	colony stimulating factor 3	Homo sapiens	130-135
28840583-8	2017	Child-Turcotte-Pugh (CTP) and Model for End-Stage Liver Disease (MELD), disease severity scores improved in patients treated with G-CSF, with significant difference only for the CTP score at 90 days follow-up.	Cytidine Triphosphate	178-181	colony stimulating factor 3	Homo sapiens	130-135
29467716-5	2018	Acute infarct core volume on CTP was the strongest univariate predictor of patient outcome (mRS 0-2, R2 0.497, p &lt; 0.001), followed by collateral grade (mRS 0-2, R2 0.281, p &lt; 0.001).	Cytidine Triphosphate	29-32	sterile alpha motif domain containing 11	Mus musculus	92-95
29017796-10	2017	RESULTS: In human keratinocytes, TARC and TSLP mRNA and protein levels were inhibited significantly by CTP treatment under AD-like inflammation.	Cytidine Triphosphate	103-106	C-C motif chemokine ligand 17	Homo sapiens	33-37
29017796-10	2017	RESULTS: In human keratinocytes, TARC and TSLP mRNA and protein levels were inhibited significantly by CTP treatment under AD-like inflammation.	Cytidine Triphosphate	103-106	thymic stromal lymphopoietin	Homo sapiens	42-46
29017796-12	2017	STAT1 phosphorylation was significantly decreased by CTP in a dose-dependent manner.	Cytidine Triphosphate	53-56	signal transducer and activator of transcription 1	Homo sapiens	0-5
29017796-15	2017	A significant reduction in the serum TARC level was observed only in the CTP group at week 12.	Cytidine Triphosphate	73-76	C-C motif chemokine ligand 17	Homo sapiens	37-41
28655658-10	2017	Herein, we developed a well-defined, multifunctional and cell-specific lipidic peptide DEN-K(GALA)-TAT-K(STR)-CTP as a breast cancer cell targeted gene delivery vector.	Cytidine Triphosphate	110-113	galactosidase alpha	Homo sapiens	93-97
28922439-9	2017	Serum IL-22 also correlated with MELD score (rs=0.32, p=0.007) and CTP score (rs=0.28, p=0.02).	Cytidine Triphosphate	67-70	interleukin 22	Homo sapiens	6-11
28237366-9	2017	In the analysis of absolute CTP parameters, CBF and MTT had areas under the curve (AUC) &gt;0.75 and the optimal threshold value was 40.4mL/100g/min and 3.78seconds, respectively.	Cytidine Triphosphate	28-31	CCAAT enhancer binding protein zeta	Homo sapiens	44-47
28217959-2	2017	In a recent study of 16 CTP-negative scleroderma patients with coincident cancer, 25% of the patients were found to have autoantibodies to RNPC-3, a member of the minor spliceosome complex.	Cytidine Triphosphate	24-27	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	139-145
28839517-3	2017	Receiver operating characteristic (ROC) curves were constructed to find an optimal cholinesterase level predicting ascites, Child Turcotte Pugh (CTP) score &gt;= 10, model for end stage liver disease (MELD) score &gt;= 15, baseline-event-anticipation (BEA) score for hepatitis D &gt;= 5 and the aspartate transaminase to Platelet Ratio Index (APRI) &gt;= 1.5.	Cytidine Triphosphate	145-148	butyrylcholinesterase	Homo sapiens	83-97
28839517-10	2017	CONCLUSION: Serum cholinesterase demonstrates promising correlations with serum albumin, INR and CTP, MELD, BEA and APRI scores and is predictive of liver reserves in hepatitis D cirrhosis.	Cytidine Triphosphate	97-100	butyrylcholinesterase	Homo sapiens	18-32
28676225-1	2017	Cytidine triphosphate synthase 1 (CTPS1) is an enzyme expressed in activated lymphocytes that catalyzes the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) with ATP-dependent amination, using either L-glutamine or ammonia as the nitrogen source.	Cytidine Triphosphate	152-173	CTP synthase 1	Homo sapiens	0-32
28676225-1	2017	Cytidine triphosphate synthase 1 (CTPS1) is an enzyme expressed in activated lymphocytes that catalyzes the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) with ATP-dependent amination, using either L-glutamine or ammonia as the nitrogen source.	Cytidine Triphosphate	152-173	CTP synthase 1	Homo sapiens	34-39
28676225-1	2017	Cytidine triphosphate synthase 1 (CTPS1) is an enzyme expressed in activated lymphocytes that catalyzes the conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) with ATP-dependent amination, using either L-glutamine or ammonia as the nitrogen source.	Cytidine Triphosphate	34-37	CTP synthase 1	Homo sapiens	0-32
28676225-2	2017	Since CTP plays an important role in DNA/RNA synthesis, phospholipid synthesis, and protein sialyation, CTPS1-inhibition is expected to control lymphocyte proliferation and size expansion in inflammatory diseases.	Cytidine Triphosphate	6-9	CTP synthase 1	Homo sapiens	104-109
27957644-2	2017	The aim of our study was to compare the BST with the fluoroscopically guided technique (FGT), with specific regard to catheter tip position (CTP).	Cytidine Triphosphate	141-144	TOR signaling pathway regulator	Homo sapiens	127-130
28217959-8	2017	Twelve patients (3.8% of the overall group or 12.2% of CTP-negative patients) were positive for anti-RNPC-3.	Cytidine Triphosphate	55-58	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	101-107
28332633-3	2017	Here, we present the crystal structure of zebrafish P2X4 in complex with a weak affinity agonist, CTP, together with structure-based electrophysiological and spectroscopic analyses.	Cytidine Triphosphate	98-101	purinergic receptor P2X, ligand-gated ion channel, 4a	Danio rerio	52-56
28342900-2	2017	The CTP-generating enzyme CTP synthase forms long filamentous structures termed cytoophidia in bacteria, yeast, fruit flies and human cells independent of its catalytic activity.	Cytidine Triphosphate	4-7	CTP synthase	Drosophila melanogaster	26-38
28614928-7	2017	Significant positive correlations were found between high or median CTP exposure and the urine concentration of 1-OH-Nap 2-OH-Nap 1-OH-Pyr in exposure groups (P&lt;0.05) .	Cytidine Triphosphate	68-71	napsin B aspartic peptidase, pseudogene	Homo sapiens	117-122
28614928-7	2017	Significant positive correlations were found between high or median CTP exposure and the urine concentration of 1-OH-Nap 2-OH-Nap 1-OH-Pyr in exposure groups (P&lt;0.05) .	Cytidine Triphosphate	68-71	nucleosome assembly protein 1 like 1	Homo sapiens	126-131
28396038-10	2017	Multivariable linear regression analysis showed that CC (vs. known aetiology, Beta = -0.144, p=0.018), platelet count (Beta = 0.398, p &lt; 0.001) and CTP score (Beta = -0.133, p=0.022) were associated with log-LAL activity.	Cytidine Triphosphate	151-154	lipase A, lysosomal acid type	Homo sapiens	211-214
27575455-6	2017	This effect was reduced by overexpression of the yeast CCA1 gene encoding ATP(CTP):tRNA nucleotidyltransferase.	Cytidine Triphosphate	78-81	tRNA adenylyltransferase	Saccharomyces cerevisiae S288C	55-59
28455894-9	2017	RESULTS: It was only after twelve years that there was a significant beneficial improvement in the mean GAF score in the CTP group (p = 0.036), which was comparable with the results obtained by Watt and Shepherd for the course of the illness in favorable remission cases (p = 0.038).	Cytidine Triphosphate	121-124	fibroblast growth factor 9	Homo sapiens	104-107
27932411-2	2017	C-terminal peptide (CTP)-modified growth hormone (MOD-4023) is being developed as a once-weekly dosing regimen in patients with GH deficiency (GHD).	Cytidine Triphosphate	20-23	growth hormone 1	Homo sapiens	34-48
28107416-1	2017	BACKGROUND: Recently, a modified insulin-like growth factor-1 (IGF)-Child-Turcotte-Pugh (CTP) classification was proposed to improve the original CTP classification.	Cytidine Triphosphate	89-92	insulin like growth factor 1	Homo sapiens	33-61
26847330-1	2016	BACKGROUND: Combining non-contrast CT (NCCT), CT angiography (CTA), and CT perfusion (CTP) imaging (referred to as a CT stroke study, CTSS) provides a rapid evaluation of the cerebrovascular axis during acute ischemic stroke.	Cytidine Triphosphate	86-89	cathepsin S	Homo sapiens	134-138
27834677-1	2016	In the yeast Saccharomyces cerevisiae, Dgk1 diacylglycerol (DAG) kinase catalyzes the CTP-dependent phosphorylation of DAG to form phosphatidic acid (PA).	Cytidine Triphosphate	86-89	diacylglycerol kinase	Saccharomyces cerevisiae S288C	39-43
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Cytidine Triphosphate	53-56	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	94-97
27825122-5	2016	The knockdown of CLIC1 in A2780 cell line downregulated expression of CTPS1, leading to the decrease of CTP and an arrest of cell cycle G1 phase, which results into a slower proliferation.	Cytidine Triphosphate	70-73	chloride intracellular channel 1	Homo sapiens	17-22
27186678-0	2016	Biological characteristics of renal cancer cells after CTP-mediated cancer suppressor gene NPRL2 protein treatment.	Cytidine Triphosphate	55-58	NPR2 like, GATOR1 complex subunit	Homo sapiens	91-96
27186678-5	2016	In this article, CTP was used to directly mediate NPRL2 protein into the renal cancer cell line 786-O, then cell proliferation was detected by the CCK-8 method, cell cycle and apoptosis were detected by flow cytometry, cell invasion and migration ability were detected by the Transwell assay.	Cytidine Triphosphate	17-20	NPR2 like, GATOR1 complex subunit	Homo sapiens	50-55
27186678-7	2016	The result showed that CTP successfully mediated NPRL2 protein into renal cancer cells and the growth of cells was significantly inhibited.	Cytidine Triphosphate	23-26	NPR2 like, GATOR1 complex subunit	Homo sapiens	49-54
27905560-6	2016	Neutrophils were isolated from peripheral blood and cell surface markers were measured by flow cytometry.EMR2 expression levels correlated with CTP scores and increased further in patients with infections.	Cytidine Triphosphate	144-147	adhesion G protein-coupled receptor E2	Homo sapiens	105-109
27905560-11	2016	In conclusion, EMR2 expression levels correlated with CTP scores and increased further in cirrhotic patients with infections.	Cytidine Triphosphate	54-57	adhesion G protein-coupled receptor E2	Homo sapiens	15-19
27443959-2	2016	The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC).	Cytidine Triphosphate	53-56	cut-like homeobox 1	Rattus norvegicus	183-186
27443959-4	2016	The goal of this research was to develop a CCT enzyme assay that employed separation of non-radioactive CDP-choline from CTP.	Cytidine Triphosphate	121-124	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	43-46
27443959-8	2016	The HPLC method was applied to glycerol 3-phosphate cytidylyltransferase (GCT) and CTP:2-C-methyl-D-erythritol-4-phosphate cytidylyltransferase synthetase (CMS), members of the cytidylyltransferase family that produce CDP-glycerol and CDP-methylerythritol, respectively.	Cytidine Triphosphate	83-86	cut-like homeobox 1	Rattus norvegicus	218-221
27443959-8	2016	The HPLC method was applied to glycerol 3-phosphate cytidylyltransferase (GCT) and CTP:2-C-methyl-D-erythritol-4-phosphate cytidylyltransferase synthetase (CMS), members of the cytidylyltransferase family that produce CDP-glycerol and CDP-methylerythritol, respectively.	Cytidine Triphosphate	83-86	cut-like homeobox 1	Rattus norvegicus	235-238
27351282-5	2016	DCs pulsed with CTP-FoxM1 could induce specific CTLs.	Cytidine Triphosphate	16-19	forkhead box M1	Mus musculus	20-25
27351282-6	2016	More importantly, the immunity induced by DCs loaded with CTP-FoxM1 could significantly inhibit tumor growth and metastasis in HCC-bearing mice, which was more potent than that induced by DCs loaded with FoxM1 or CTP, alone.	Cytidine Triphosphate	58-61	forkhead box M1	Mus musculus	62-67
27351282-6	2016	More importantly, the immunity induced by DCs loaded with CTP-FoxM1 could significantly inhibit tumor growth and metastasis in HCC-bearing mice, which was more potent than that induced by DCs loaded with FoxM1 or CTP, alone.	Cytidine Triphosphate	58-61	forkhead box M1	Mus musculus	204-209
27351282-6	2016	More importantly, the immunity induced by DCs loaded with CTP-FoxM1 could significantly inhibit tumor growth and metastasis in HCC-bearing mice, which was more potent than that induced by DCs loaded with FoxM1 or CTP, alone.	Cytidine Triphosphate	213-216	forkhead box M1	Mus musculus	62-67
27351282-7	2016	Our results indicate that DCs pulsed with CTP-FoxM1 might be a promising vaccine candidate for HCC therapy and provide new insight into the design of DC-based immunotherapy.	Cytidine Triphosphate	42-45	forkhead box M1	Mus musculus	46-51
27427704-2	2016	Chitosan-mediated AuNFs exhibited the distinct SERS signals of 2-chlorothiophenol (CTP) due to the presence of many interstitial gaps (so called hot spots) on the surface.	Cytidine Triphosphate	83-86	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	47-51
27427704-4	2016	The resulting core-shell particles, i.e., CTP-adsorbed AuNFs with silica coating, exhibited the distinct SERS signals of CTP embedded within silica layer, warranting the effectiveness of this chemical strategy for spectroscopic labeling of Raman probes.	Cytidine Triphosphate	42-45	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	105-109
27427704-4	2016	The resulting core-shell particles, i.e., CTP-adsorbed AuNFs with silica coating, exhibited the distinct SERS signals of CTP embedded within silica layer, warranting the effectiveness of this chemical strategy for spectroscopic labeling of Raman probes.	Cytidine Triphosphate	121-124	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	105-109
26830094-5	2016	CONCLUSION: A long-acting endostatin can be produced using CTP technology.	Cytidine Triphosphate	59-62	collagen type XVIII alpha 1 chain	Homo sapiens	26-36
26986626-6	2016	The CCTs from CTP (CT-CCT) were defined as the differences in TTP from the corresponding arterial ROIs and the SSS.	Cytidine Triphosphate	14-17	CCT	Homo sapiens	4-7
26552690-1	2016	CDP-DAG is a liponucleotide formed by the condensation of CTP with the phospholipid phosphatidic acid in a reaction catalyzed by CDP-DAG synthase (CDS).	Cytidine Triphosphate	58-61	cut like homeobox 1	Homo sapiens	0-3
26806490-3	2016	In this work, we have used a strategy based on the fusion of the carboxyl-terminal peptide (CTP) of human chorionic gonadotropin (hCG) beta-subunit, bearing four O-linked oligosaccharide recognition sites, to each or both N- and C-terminal ends of rhIFN-alpha2b.	Cytidine Triphosphate	92-95	chorionic gonadotropin subunit beta 5	Homo sapiens	130-133
26713839-0	2016	In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone.	Cytidine Triphosphate	91-94	growth hormone 1	Homo sapiens	111-125
26713839-1	2016	MOD-4023 is a novel long-acting version of human growth hormone (hGH), containing the carboxy-terminal peptide (CTP) of human chorionic gonadotropin (hCG).	Cytidine Triphosphate	112-115	growth hormone 1	Homo sapiens	49-63
26713839-1	2016	MOD-4023 is a novel long-acting version of human growth hormone (hGH), containing the carboxy-terminal peptide (CTP) of human chorionic gonadotropin (hCG).	Cytidine Triphosphate	112-115	chorionic gonadotropin subunit beta 5	Homo sapiens	126-154
26723988-11	2016	CONCLUSION: All three CTP modes had adequate sensitivity but very high specificity, and among the three CTP modes, CBF had the best diagnostic characteristics.	Cytidine Triphosphate	104-107	CCAAT enhancer binding protein zeta	Homo sapiens	115-118
26507856-1	2016	NBDB database describes protein motifs, elementary functional loops (EFLs) that are involved in binding of nucleotide-containing ligands and other biologically relevant cofactors/coenzymes, including ATP, AMP, ATP, GMP, GDP, GTP, CTP, PAP, PPS, FMN, FAD(H), NAD(H), NADP, cAMP, cGMP, c-di-AMP and c-di-GMP, ThPP, THD, F-420, ACO, CoA, PLP and SAM.	Cytidine Triphosphate	230-233	proteolipid protein 1	Homo sapiens	335-338
26873085-8	2016	A significant positive correlation of transferrin saturation with Child-Turcotte-Pugh (CTP) score (r = 0.705, p &lt; 0.001) and model for end-stage liver disease (MELD) score (r = 0.668, p &lt; 0.001) was found.	Cytidine Triphosphate	87-90	transferrin	Homo sapiens	38-49
26873085-9	2016	Transferrin saturation was also independently associated with high CTP and MELD score on multivariate analysis.	Cytidine Triphosphate	67-70	transferrin	Homo sapiens	0-11
26552690-1	2016	CDP-DAG is a liponucleotide formed by the condensation of CTP with the phospholipid phosphatidic acid in a reaction catalyzed by CDP-DAG synthase (CDS).	Cytidine Triphosphate	58-61	TAM41 mitochondrial translocator assembly and maintenance homolog	Homo sapiens	129-145
26552690-1	2016	CDP-DAG is a liponucleotide formed by the condensation of CTP with the phospholipid phosphatidic acid in a reaction catalyzed by CDP-DAG synthase (CDS).	Cytidine Triphosphate	58-61	TAM41 mitochondrial translocator assembly and maintenance homolog	Homo sapiens	147-150
25707436-8	2015	The most potent Fab fragment (2A4(GTP)) showed over 100-fold GTP-specificity over GDP, ATP, or CTP and was used to develop a heterogeneous time-resolved luminescence based assay for the monitoring of GTP concentration.	Cytidine Triphosphate	95-98	FA complementation group B	Homo sapiens	16-19
26334382-9	2015	In high risk/known CAD patients with CAC 1-399, diagnostic performance for CTA-CTP (77) was superior to CTP (71, p=0.037) alone.	Cytidine Triphosphate	79-82	transmembrane protein 54	Homo sapiens	37-42
26630542-13	2015	As characteristic of NDK"s NTP substrate non-specificity, it used CTP, TTP, and UTP also to convert GDP to GTP, to trigger FtsZ polymerisation.	Cytidine Triphosphate	66-69	cytidine/uridine monophosphate kinase 2	Homo sapiens	21-24
26630542-16	2015	CONCLUSION: Irrespective of the bacterial species, NDK interacts with FtsZ in vitro and ex vivo and, through the synthesis of GTP from FtsZ-bound GDP and/or free GDP, and ATP (CTP/TTP/UTP), triggers FtsZ polymerisation.	Cytidine Triphosphate	176-179	cytidine/uridine monophosphate kinase 2	Homo sapiens	51-54
27215023-3	2015	This study aimed to determine the possible neural path- ways of CTP and whether serum leptin level and the leptin receptor (OB-Rb) in the hind brain are involved following CTP formation.	Cytidine Triphosphate	172-175	leptin receptor	Rattus norvegicus	107-122
27215023-8	2015	In addition, we found OB-Rb mRNA expression in PBN of CTP group rats was higher than that of control group (0.95 +- 0.055 vs 0.57 +- 0.034, P &lt; 0.05), while there was no significant difference of OB-Rb mRNA expression in NST between the two groups.	Cytidine Triphosphate	54-57	sulfotransferase family 4A, member 1	Rattus norvegicus	224-227
27215023-9	2015	CONCLUSION: Nuclei AH, BLA, NST, VMH, PBN and CeA participate in the formation of CTP.	Cytidine Triphosphate	82-85	sulfotransferase family 4A, member 1	Rattus norvegicus	28-31
27215023-9	2015	CONCLUSION: Nuclei AH, BLA, NST, VMH, PBN and CeA participate in the formation of CTP.	Cytidine Triphosphate	82-85	carcinoembryonic antigen gene family 4	Rattus norvegicus	46-49
26243227-7	2015	RESULTS: In 4369 scans from 507 patients, CTP was more strongly correlated with RC-ABC (r(2)=0.93) than with site-ABC (r(2)=0.87).	Cytidine Triphosphate	42-45	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	83-86
26243227-11	2015	RC-ABC had moderate accuracy for detecting &gt;=5 mL change in CTP volume between consecutive scans (sensitivity, 0.76; specificity, 0.86) and was more accurate with smaller ICH, thalamic hemorrhage, and homogeneous clots.	Cytidine Triphosphate	63-66	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	3-6
26098859-2	2015	Recently, we reported that integrating plasma insulin-like growth factor-1 (IGF-1) level into the CTP score was associated with better patient risk stratification in two U.S. independent cohorts.	Cytidine Triphosphate	98-101	insulin like growth factor 1	Homo sapiens	46-74
26098859-2	2015	Recently, we reported that integrating plasma insulin-like growth factor-1 (IGF-1) level into the CTP score was associated with better patient risk stratification in two U.S. independent cohorts.	Cytidine Triphosphate	98-101	insulin like growth factor 1	Homo sapiens	76-81
25817622-8	2015	RESULTS: Of 4 CTP parameters evaluated, statistically significant correlations were observed between time to peak (TTP) by CTP and CVRC (P &lt; .0001, r = -.7228) calculated from XeCT.	Cytidine Triphosphate	14-17	ZFP36 ring finger protein	Homo sapiens	115-118
25817622-8	2015	RESULTS: Of 4 CTP parameters evaluated, statistically significant correlations were observed between time to peak (TTP) by CTP and CVRC (P &lt; .0001, r = -.7228) calculated from XeCT.	Cytidine Triphosphate	123-126	ZFP36 ring finger protein	Homo sapiens	115-118
25817622-11	2015	CONCLUSIONS: TTP calculated from CTP data correlated well with the CVRC calculated from XeCT data.	Cytidine Triphosphate	33-36	ZFP36 ring finger protein	Homo sapiens	13-16
25817622-12	2015	These results suggest that TTP calculated from CTP could be used to estimate CVRC in patients with occlusive cardiovascular disease.	Cytidine Triphosphate	47-50	ZFP36 ring finger protein	Homo sapiens	27-30
26222701-8	2015	Thrombin generation assessed CTP-related thrombogenicity.	Cytidine Triphosphate	29-32	coagulation factor II, thrombin	Homo sapiens	0-8
26303200-5	2015	First, we find that an elevated intracellular CTP concentration or treatment with 3"-deazauridine, a CTPS inhibitor, promotes IMPDH cytoophidium formation and increases the intracellular GTP pool size.	Cytidine Triphosphate	46-49	CTP synthase 1	Homo sapiens	101-105
26183802-9	2015	A multivariate model showed that nontumor variables (patient"s age, Child-Turcotte-Pugh [CTP] class, and alternative therapies) had the potential to shift the AFP model threshold of LT cost-ineffectiveness from 3 to 7.	Cytidine Triphosphate	89-92	alpha fetoprotein	Homo sapiens	159-162
25307895-4	2015	The Alberta Stroke Program Early Computed Tomography Scoring (ASPECTS) was used to assess the time-to-peak (TTP) parameter of Computer tomography perfusion (CTP).	Cytidine Triphosphate	157-160	ZFP36 ring finger protein	Homo sapiens	108-111
25943764-5	2015	However, human liver microsomes cleared CTP-347 faster than paroxetine as a result of decreased inactivation of CYP2D6.	Cytidine Triphosphate	40-43	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	112-118
25943764-7	2015	These alterations in the metabolism profile resulted in significantly reduced drug-drug interactions between CTP-347 and two other CYP2D6-metabolized drugs: tamoxifen (in vitro) and dextromethorphan (in humans).	Cytidine Triphosphate	109-112	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	131-137
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	47-68	CTP synthase 1	Homo sapiens	202-232
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	47-68	CTP synthase 1	Homo sapiens	234-238
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	47-68	inosine monophosphate dehydrogenase 2	Homo sapiens	244-284
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	47-68	inosine monophosphate dehydrogenase 2	Homo sapiens	286-292
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	70-73	CTP synthase 1	Homo sapiens	202-232
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	70-73	CTP synthase 1	Homo sapiens	234-238
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	70-73	inosine monophosphate dehydrogenase 2	Homo sapiens	244-284
26165495-1	2015	Inhibition of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) biosynthetic pathways induces cells to assemble rod/ring (RR) structures, also named cytoophidia, which consist of the enzymes cytidine triphosphate synthase (CTPS) and inosine-5"-monophosphate dehydrogenase 2 (IMPDH2).	Cytidine Triphosphate	70-73	inosine monophosphate dehydrogenase 2	Homo sapiens	286-292
25775471-7	2015	Furthermore, CTP patients with cardiovascular involvement were significantly older, had higher systolic and diastolic pressures, C-reactive protein, glucose, and uric acid, higher rates of diabetes, hypertension, and use of moderate- to high-dose glucocorticoids, and longer disease duration compared to patients without involvement (all p &lt; 0.05).	Cytidine Triphosphate	13-16	C-reactive protein	Homo sapiens	129-147
25452893-2	2014	Methods Retrospective review was performed of STA-MCA bypass patients with steno-occlusive disease with CTP before and after surgery.	Cytidine Triphosphate	104-107	GCY	Homo sapiens	46-49
25452893-8	2014	Conclusions Blood flow augmentation after STA-MCA bypass may best be assessed by CTP using baseline MTT or TTP and ratios of MTT, TTP, or CBF to the contralateral hemisphere.	Cytidine Triphosphate	81-84	GCY	Homo sapiens	42-45
24832487-5	2014	This growth suppression was observed even if the Kennedy pathway was inactivated by the repression of PCT1 encoding CTP:phosphocholine cytidylyltransferase, suggesting that PC synthesized in the mitochondria is distributed to other organelles without going through the salvage pathway.	Cytidine Triphosphate	116-119	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	102-106
25146485-5	2014	A previous report suggested that the cTP cleavage site of CGS is located upstream of the MTO1 region.	Cytidine Triphosphate	37-40	Pyridoxal phosphate (PLP)-dependent transferases superfamily protein	Arabidopsis thaliana	89-93
24802409-3	2014	The catalytic reaction of hECT obeyed Michaelis-Menten kinetics with respect to both CTP and phosphoethanolamine.	Cytidine Triphosphate	85-88	ECT	Homo sapiens	26-30
25134433-4	2014	METHODS: NF-kappaB reporter cells were established and treated with 5-fluorouracil (5-FU, DNA/RNA damaging), oxaliplatin (DNA damaging), camptothecin (CTP, topoisomerase inhibitor), phleomycin (radiomimetic), or erlotinib (EGFR inhibitor).	Cytidine Triphosphate	151-154	nuclear factor kappa B subunit 1	Homo sapiens	9-18
24477477-1	2014	Rods and rings (RR) are protein assemblies composed of cytidine triphosphate synthetase type 1 (CTPS1) and inosine monophosphate dehydrogenase type 2 (IMPDH2), key enzymes in CTP and GTP biosynthesis.	Cytidine Triphosphate	96-99	CTP synthase 1	Homo sapiens	55-94
24870241-3	2014	CTP originates from two sources: a salvage pathway and a de novo synthesis pathway that depends on two enzymes, the CTP synthases (or synthetases) 1 and 2 (CTPS1 with CTPS2); the respective roles of these two enzymes are not known.	Cytidine Triphosphate	0-3	CTP synthase 1	Homo sapiens	156-161
24870241-3	2014	CTP originates from two sources: a salvage pathway and a de novo synthesis pathway that depends on two enzymes, the CTP synthases (or synthetases) 1 and 2 (CTPS1 with CTPS2); the respective roles of these two enzymes are not known.	Cytidine Triphosphate	0-3	CTP synthase 2	Homo sapiens	167-172
24870241-8	2014	Normal T-cell proliferation was restored in CTPS1-deficient cells by expressing wild-type CTPS1 or by addition of exogenous CTP or its nucleoside precursor, cytidine.	Cytidine Triphosphate	44-47	CTP synthase 1	Homo sapiens	90-95
24906132-7	2014	Patients with CTP class 0 had a higher serum sodium level, lower serum creatinine, alanine aminotransferase, alpha-fetoprotein levels, shorter prothrombin time, better general well-being, smaller tumor burden with more solitary nodules, lower rates of vascular invasion, ascites formation, hepatic encephalopathy, more frequently treated with curative interventions and better Barcelona Clinic Liver Cancer (BCLC) stages (all p&lt;0.001).	Cytidine Triphosphate	14-17	glutamic--pyruvic transaminase	Homo sapiens	83-107
24906132-7	2014	Patients with CTP class 0 had a higher serum sodium level, lower serum creatinine, alanine aminotransferase, alpha-fetoprotein levels, shorter prothrombin time, better general well-being, smaller tumor burden with more solitary nodules, lower rates of vascular invasion, ascites formation, hepatic encephalopathy, more frequently treated with curative interventions and better Barcelona Clinic Liver Cancer (BCLC) stages (all p&lt;0.001).	Cytidine Triphosphate	14-17	alpha fetoprotein	Homo sapiens	109-126
24674841-7	2014	There were negative correlations between Tbeta4 levels and CTP scores (P&lt;0.001), MELD scores (P&lt;0.001).	Cytidine Triphosphate	59-62	thymosin beta 4 X-linked	Homo sapiens	41-47
24815863-3	2014	We hypothesized that plasma insulin-like growth factor 1 (IGF-1) is a valid surrogate for hepatic reserve to replace the subjective parameters in CTP score to improve its prognostic accuracy.	Cytidine Triphosphate	146-149	insulin like growth factor 1	Homo sapiens	28-56
24815863-3	2014	We hypothesized that plasma insulin-like growth factor 1 (IGF-1) is a valid surrogate for hepatic reserve to replace the subjective parameters in CTP score to improve its prognostic accuracy.	Cytidine Triphosphate	146-149	insulin like growth factor 1	Homo sapiens	58-63
24288211-4	2014	Among the numerous metabolites analyzed, stable reduction in the intracellular level of ATP, GTP, CTP, or UTP was observed, indicating a profound role of CCN2 in energy metabolism.	Cytidine Triphosphate	98-101	cellular communication network factor 2	Mus musculus	154-158
24614195-4	2014	In the present study, we evaluated specific immune responses of CTP-HBcAg(18-27)-Tapasin fusion protein in HLA-A2 transgenic mice (H-2K(b)) and anti-viral ability in HBV transgenic mice, and explored the mechanisms probably involved in.	Cytidine Triphosphate	64-67	TAP binding protein	Mus musculus	81-88
24614195-4	2014	In the present study, we evaluated specific immune responses of CTP-HBcAg(18-27)-Tapasin fusion protein in HLA-A2 transgenic mice (H-2K(b)) and anti-viral ability in HBV transgenic mice, and explored the mechanisms probably involved in.	Cytidine Triphosphate	64-67	histocompatibility 2, K1, K region	Mus musculus	131-138
24694764-0	2014	CTP infarct core may predict poor outcome in stroke patients treated with IV t-PA.	Cytidine Triphosphate	0-3	plasminogen activator, tissue type	Homo sapiens	77-81
24614195-5	2014	The studies showed that CTP-HBcAg(18-27)-Tapasin not only increased production of cytokine IFN-gamma and interleukin-2 (IL-2), compared with CTP-HBcAg(18-27), HBcAg(18-27)-Tapasin, and PBS, but also significantly induced the higher percentages of IFN-gamma+CD8(+) T cells and specific CTL responses in HLA-A2 transgenic mice.	Cytidine Triphosphate	24-27	TAP binding protein	Mus musculus	41-48
24614195-5	2014	The studies showed that CTP-HBcAg(18-27)-Tapasin not only increased production of cytokine IFN-gamma and interleukin-2 (IL-2), compared with CTP-HBcAg(18-27), HBcAg(18-27)-Tapasin, and PBS, but also significantly induced the higher percentages of IFN-gamma+CD8(+) T cells and specific CTL responses in HLA-A2 transgenic mice.	Cytidine Triphosphate	24-27	interferon gamma	Mus musculus	91-100
24614195-5	2014	The studies showed that CTP-HBcAg(18-27)-Tapasin not only increased production of cytokine IFN-gamma and interleukin-2 (IL-2), compared with CTP-HBcAg(18-27), HBcAg(18-27)-Tapasin, and PBS, but also significantly induced the higher percentages of IFN-gamma+CD8(+) T cells and specific CTL responses in HLA-A2 transgenic mice.	Cytidine Triphosphate	24-27	interleukin 2	Mus musculus	105-118
24614195-5	2014	The studies showed that CTP-HBcAg(18-27)-Tapasin not only increased production of cytokine IFN-gamma and interleukin-2 (IL-2), compared with CTP-HBcAg(18-27), HBcAg(18-27)-Tapasin, and PBS, but also significantly induced the higher percentages of IFN-gamma+CD8(+) T cells and specific CTL responses in HLA-A2 transgenic mice.	Cytidine Triphosphate	24-27	interleukin 2	Mus musculus	120-124
24614195-5	2014	The studies showed that CTP-HBcAg(18-27)-Tapasin not only increased production of cytokine IFN-gamma and interleukin-2 (IL-2), compared with CTP-HBcAg(18-27), HBcAg(18-27)-Tapasin, and PBS, but also significantly induced the higher percentages of IFN-gamma+CD8(+) T cells and specific CTL responses in HLA-A2 transgenic mice.	Cytidine Triphosphate	24-27	TAP binding protein	Mus musculus	172-179
24614195-7	2014	In addition, CTP-HBcAg(18-27)-Tapasin could upregulate the expression of JAK2, Tyk2, STAT1, and STAT4 in T lymphocytes in HLA-A2 transgenic mice splenocytes.	Cytidine Triphosphate	13-16	tyrosine kinase 2	Mus musculus	79-83
24614195-5	2014	The studies showed that CTP-HBcAg(18-27)-Tapasin not only increased production of cytokine IFN-gamma and interleukin-2 (IL-2), compared with CTP-HBcAg(18-27), HBcAg(18-27)-Tapasin, and PBS, but also significantly induced the higher percentages of IFN-gamma+CD8(+) T cells and specific CTL responses in HLA-A2 transgenic mice.	Cytidine Triphosphate	24-27	interferon gamma	Mus musculus	247-256
24614195-7	2014	In addition, CTP-HBcAg(18-27)-Tapasin could upregulate the expression of JAK2, Tyk2, STAT1, and STAT4 in T lymphocytes in HLA-A2 transgenic mice splenocytes.	Cytidine Triphosphate	13-16	signal transducer and activator of transcription 1	Mus musculus	85-90
24614195-7	2014	In addition, CTP-HBcAg(18-27)-Tapasin could upregulate the expression of JAK2, Tyk2, STAT1, and STAT4 in T lymphocytes in HLA-A2 transgenic mice splenocytes.	Cytidine Triphosphate	13-16	TAP binding protein	Mus musculus	30-37
24535102-3	2014	Previous studies by our group showed that the expressed and purified fusion protein of cytoplasmic transduction peptide (CTP) and HBV core antigen 18-27 (HBcAg18-27)-tapasin was able to enter the cytoplasm of bone marrow-derived dendritic cells (BMDCs), promoting the maturation of BMDCs and efficiently enhancing T cell immune responses in vitro.	Cytidine Triphosphate	121-124	TAP binding protein	Homo sapiens	166-173
24614195-7	2014	In addition, CTP-HBcAg(18-27)-Tapasin could upregulate the expression of JAK2, Tyk2, STAT1, and STAT4 in T lymphocytes in HLA-A2 transgenic mice splenocytes.	Cytidine Triphosphate	13-16	signal transducer and activator of transcription 4	Mus musculus	96-101
24614195-9	2014	In conclusion, CTP-HBcAg(18-27)-Tapasin fusion protein could enhance not only the percentages of CTLs but also induce robust specific CTL activity and inhibits hepatitis B virus replication in vivo, which was associated with activation of the JAK/STAT signaling pathway.	Cytidine Triphosphate	15-18	TAP binding protein	Mus musculus	32-39
24614195-9	2014	In conclusion, CTP-HBcAg(18-27)-Tapasin fusion protein could enhance not only the percentages of CTLs but also induce robust specific CTL activity and inhibits hepatitis B virus replication in vivo, which was associated with activation of the JAK/STAT signaling pathway.	Cytidine Triphosphate	15-18	Janus kinase 1	Homo sapiens	243-246
24614195-9	2014	In conclusion, CTP-HBcAg(18-27)-Tapasin fusion protein could enhance not only the percentages of CTLs but also induce robust specific CTL activity and inhibits hepatitis B virus replication in vivo, which was associated with activation of the JAK/STAT signaling pathway.	Cytidine Triphosphate	15-18	signal transducer and activator of transcription 1	Mus musculus	247-251
24614195-7	2014	In addition, CTP-HBcAg(18-27)-Tapasin could upregulate the expression of JAK2, Tyk2, STAT1, and STAT4 in T lymphocytes in HLA-A2 transgenic mice splenocytes.	Cytidine Triphosphate	13-16	Janus kinase 2	Mus musculus	73-77
24535102-4	2014	In the present study, HBcAg-specific immune responses induced by CTP-HBcAg18-27-tapasin in HBV were assessed in transgenic mice, and SOCS1 and SOCS3 were identified as negative regulators of this response.	Cytidine Triphosphate	65-68	TAP binding protein	Homo sapiens	80-87
24535102-7	2014	The results demonstrated that CTP-HBcAg18-27-tapasin significantly increased the Th1/Th2 cytokine ratio in HBV transgenic mice.	Cytidine Triphosphate	30-33	TAP binding protein	Homo sapiens	45-52
24535102-7	2014	The results demonstrated that CTP-HBcAg18-27-tapasin significantly increased the Th1/Th2 cytokine ratio in HBV transgenic mice.	Cytidine Triphosphate	30-33	negative elongation factor complex member C/D	Homo sapiens	81-84
24535102-8	2014	CTP-HBcAg18-27-tapasin immunization more efficiently suppressed the expression of serum hepatitis B surface antigen (HBsAg), HBV DNA as well as liver HBsAg and HBcAg in HBV transgenic mice.	Cytidine Triphosphate	0-3	TAP binding protein	Homo sapiens	15-22
24535102-9	2014	Furthermore, CTP-HBcAg18-27-tapasin promotes T-bet but reduces GATA-3 expression.	Cytidine Triphosphate	13-16	TAP binding protein	Homo sapiens	28-35
24569815-8	2014	Specifically, higher rates of recombinant tissue-type plasminogen activator were observed in CTA (10.2%) and CTP (11.4%) compared with those with CT head alone (3.8%; P&lt;0.0001).	Cytidine Triphosphate	109-112	plasminogen activator, tissue type	Homo sapiens	42-75
24239648-3	2014	Although CTP-like sequences are encrypted in the LHbeta genes of several mammals, the CGbeta subunit developed only in primates and equids.	Cytidine Triphosphate	9-12	luteinizing hormone subunit beta	Homo sapiens	49-55
24491568-1	2014	A yeast strain, in which endogenous phosphatidylcholine (PC) synthesis is controllable, was constructed by the replacement of the promoter of PCT1, encoding CTP:phosphocholine cytidylyltransferase, with GAL1 promoter in a double deletion mutant of PEM1 and PEM2, encoding phosphatidylethanolamine methyltransferase and phospholipid methyltransferase, respectively.	Cytidine Triphosphate	157-160	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	142-146
24693311-0	2014	The Fusion Protein of CTP-HBcAg18-27-Tapasin Mediates the Apoptosis of CD8(+)T Cells and CD8(+) T Cell Response in HLA-A2 Transgenic Mice.	Cytidine Triphosphate	22-25	TAP binding protein	Mus musculus	37-44
24693311-4	2014	OBJECTIVES: In the present study, we evaluated specific CTL response and the level of apoptosis of CD8+ T cells induced by CTP-HBcAg18-27-Tapasin in HLA-A2 transgenic mice (H-2Kb).	Cytidine Triphosphate	123-126	TAP binding protein	Mus musculus	138-145
24693311-10	2014	Moreover, the expression of PI3K, P-Akt, and P-mTOR was significantly upregulated in CTP-HBcAg18-27-Tapasin group compared with control groups.	Cytidine Triphosphate	85-88	thymoma viral proto-oncogene 1	Mus musculus	36-39
24693311-10	2014	Moreover, the expression of PI3K, P-Akt, and P-mTOR was significantly upregulated in CTP-HBcAg18-27-Tapasin group compared with control groups.	Cytidine Triphosphate	85-88	mechanistic target of rapamycin kinase	Homo sapiens	47-51
24693311-10	2014	Moreover, the expression of PI3K, P-Akt, and P-mTOR was significantly upregulated in CTP-HBcAg18-27-Tapasin group compared with control groups.	Cytidine Triphosphate	85-88	TAP binding protein	Mus musculus	100-107
24693311-11	2014	CONCLUSIONS: In conclusion, CTP-HBcAg18-27-Tapasin could reduce apoptosis of CD8(+) T cells, increase the percentages of IFN-gamma(+) CD8alpha(+) T cells, and elicit cell-mediated immunity in HLA-A2 transgenic mice; these processes were associated with activation of the PI3K/Akt signaling pathway.	Cytidine Triphosphate	28-31	TAP binding protein	Mus musculus	43-50
24693311-11	2014	CONCLUSIONS: In conclusion, CTP-HBcAg18-27-Tapasin could reduce apoptosis of CD8(+) T cells, increase the percentages of IFN-gamma(+) CD8alpha(+) T cells, and elicit cell-mediated immunity in HLA-A2 transgenic mice; these processes were associated with activation of the PI3K/Akt signaling pathway.	Cytidine Triphosphate	28-31	interferon gamma	Mus musculus	121-130
24693311-11	2014	CONCLUSIONS: In conclusion, CTP-HBcAg18-27-Tapasin could reduce apoptosis of CD8(+) T cells, increase the percentages of IFN-gamma(+) CD8alpha(+) T cells, and elicit cell-mediated immunity in HLA-A2 transgenic mice; these processes were associated with activation of the PI3K/Akt signaling pathway.	Cytidine Triphosphate	28-31	CD8 antigen, alpha chain	Mus musculus	134-142
24693311-11	2014	CONCLUSIONS: In conclusion, CTP-HBcAg18-27-Tapasin could reduce apoptosis of CD8(+) T cells, increase the percentages of IFN-gamma(+) CD8alpha(+) T cells, and elicit cell-mediated immunity in HLA-A2 transgenic mice; these processes were associated with activation of the PI3K/Akt signaling pathway.	Cytidine Triphosphate	28-31	thymoma viral proto-oncogene 1	Mus musculus	276-279
24239648-4	2014	To study this restriction in evolution, we examined whether the cryptic CTP decoded from the bovine LHbeta gene (boCTP) possesses key characteristics of the human (h) CGbeta-CTP.	Cytidine Triphosphate	72-75	lutropin subunit beta	Bos taurus	100-106
24239648-4	2014	To study this restriction in evolution, we examined whether the cryptic CTP decoded from the bovine LHbeta gene (boCTP) possesses key characteristics of the human (h) CGbeta-CTP.	Cytidine Triphosphate	115-118	lutropin subunit beta	Bos taurus	100-106
25050333-2	2014	METHODS: Between May 2010 and April 2012, 30 patients with head and neck SCC underwent preoperative DWI and CTP.	Cytidine Triphosphate	108-111	serpin family B member 3	Homo sapiens	73-76
24336747-3	2014	Interestingly, similar mitotic and developmental defects were observed upon knockdown of the DYNLL/LC8-type dynein light chain Cutup (Ctp), and dASCIZ loss-of-function phenotypes could be suppressed by ectopic Ctp expression.	Cytidine Triphosphate	134-137	cut up	Drosophila melanogaster	99-102
24336747-3	2014	Interestingly, similar mitotic and developmental defects were observed upon knockdown of the DYNLL/LC8-type dynein light chain Cutup (Ctp), and dASCIZ loss-of-function phenotypes could be suppressed by ectopic Ctp expression.	Cytidine Triphosphate	210-213	cut up	Drosophila melanogaster	99-102
24336747-3	2014	Interestingly, similar mitotic and developmental defects were observed upon knockdown of the DYNLL/LC8-type dynein light chain Cutup (Ctp), and dASCIZ loss-of-function phenotypes could be suppressed by ectopic Ctp expression.	Cytidine Triphosphate	210-213	ASCIZ zinc finger protein	Drosophila melanogaster	144-150
24336747-4	2014	Consistent with a genetic function of dASCIZ upstream of Ctp, we show that loss of dASCIZ led to reduced endogenous Ctp mRNA and protein levels and dramatically reduced Ctp-LacZ reporter gene activity in vivo, indicating that dASCIZ regulates development and mitosis as a Ctp transcription factor.	Cytidine Triphosphate	57-60	ASCIZ zinc finger protein	Drosophila melanogaster	38-44
24336747-4	2014	Consistent with a genetic function of dASCIZ upstream of Ctp, we show that loss of dASCIZ led to reduced endogenous Ctp mRNA and protein levels and dramatically reduced Ctp-LacZ reporter gene activity in vivo, indicating that dASCIZ regulates development and mitosis as a Ctp transcription factor.	Cytidine Triphosphate	57-60	ASCIZ zinc finger protein	Drosophila melanogaster	83-89
24336747-4	2014	Consistent with a genetic function of dASCIZ upstream of Ctp, we show that loss of dASCIZ led to reduced endogenous Ctp mRNA and protein levels and dramatically reduced Ctp-LacZ reporter gene activity in vivo, indicating that dASCIZ regulates development and mitosis as a Ctp transcription factor.	Cytidine Triphosphate	57-60	ASCIZ zinc finger protein	Drosophila melanogaster	83-89
24336747-4	2014	Consistent with a genetic function of dASCIZ upstream of Ctp, we show that loss of dASCIZ led to reduced endogenous Ctp mRNA and protein levels and dramatically reduced Ctp-LacZ reporter gene activity in vivo, indicating that dASCIZ regulates development and mitosis as a Ctp transcription factor.	Cytidine Triphosphate	116-119	ASCIZ zinc finger protein	Drosophila melanogaster	38-44
24336747-4	2014	Consistent with a genetic function of dASCIZ upstream of Ctp, we show that loss of dASCIZ led to reduced endogenous Ctp mRNA and protein levels and dramatically reduced Ctp-LacZ reporter gene activity in vivo, indicating that dASCIZ regulates development and mitosis as a Ctp transcription factor.	Cytidine Triphosphate	116-119	ASCIZ zinc finger protein	Drosophila melanogaster	83-89
24336747-4	2014	Consistent with a genetic function of dASCIZ upstream of Ctp, we show that loss of dASCIZ led to reduced endogenous Ctp mRNA and protein levels and dramatically reduced Ctp-LacZ reporter gene activity in vivo, indicating that dASCIZ regulates development and mitosis as a Ctp transcription factor.	Cytidine Triphosphate	116-119	ASCIZ zinc finger protein	Drosophila melanogaster	83-89
24535102-9	2014	Furthermore, CTP-HBcAg18-27-tapasin promotes T-bet but reduces GATA-3 expression.	Cytidine Triphosphate	13-16	T-box transcription factor 21	Homo sapiens	45-50
24535102-9	2014	Furthermore, CTP-HBcAg18-27-tapasin promotes T-bet but reduces GATA-3 expression.	Cytidine Triphosphate	13-16	GATA binding protein 3	Homo sapiens	63-69
24535102-10	2014	In addition, the expression of SOCS1 and SOCS3 was significantly downregulated in the CTP-HBcAg18-27-tapasin group compared with the control groups.	Cytidine Triphosphate	86-89	suppressor of cytokine signaling 1	Homo sapiens	31-36
24535102-10	2014	In addition, the expression of SOCS1 and SOCS3 was significantly downregulated in the CTP-HBcAg18-27-tapasin group compared with the control groups.	Cytidine Triphosphate	86-89	suppressor of cytokine signaling 3	Homo sapiens	41-46
24535102-10	2014	In addition, the expression of SOCS1 and SOCS3 was significantly downregulated in the CTP-HBcAg18-27-tapasin group compared with the control groups.	Cytidine Triphosphate	86-89	TAP binding protein	Homo sapiens	101-108
24535102-11	2014	In conclusion, the present study demonstrated that CTP-HBcAg18-27-tapasin enhanced the Th1/Th2 cytokine ratio and antiviral immunity by suppressing SOCS1/3 in HBV transgenic mice.	Cytidine Triphosphate	51-54	TAP binding protein	Homo sapiens	66-73
24535102-11	2014	In conclusion, the present study demonstrated that CTP-HBcAg18-27-tapasin enhanced the Th1/Th2 cytokine ratio and antiviral immunity by suppressing SOCS1/3 in HBV transgenic mice.	Cytidine Triphosphate	51-54	negative elongation factor complex member C/D	Homo sapiens	87-90
24535102-11	2014	In conclusion, the present study demonstrated that CTP-HBcAg18-27-tapasin enhanced the Th1/Th2 cytokine ratio and antiviral immunity by suppressing SOCS1/3 in HBV transgenic mice.	Cytidine Triphosphate	51-54	suppressor of cytokine signaling 1	Homo sapiens	148-153
23826759-15	2014	CONCLUSION: Perfusion deficits are found in TIA patients using whole brain CTP and associated with components of the ABCD2 score.	Cytidine Triphosphate	75-78	ATP binding cassette subfamily D member 2	Homo sapiens	117-122
24091918-8	2014	These results suggested that CTP-OD1 and CTP-OD2 may be an attractive therapeutic option to inhibit the activation of Bcr-Abl kinase in CML.	Cytidine Triphosphate	29-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	118-125
24411169-2	2014	Cytoplasmic structures in mammalian cells, provisionally described as rods and rings (RR), were identified by human autoantibodies and recently shown to include two key enzymes of the CTP/GTP biosynthetic pathways, cytidine triphosphate synthetase (CTPS) and inosine monophosphate dehydrogenase (IMPDH).	Cytidine Triphosphate	184-187	CTP synthase 1	Homo sapiens	215-247
24091918-8	2014	These results suggested that CTP-OD1 and CTP-OD2 may be an attractive therapeutic option to inhibit the activation of Bcr-Abl kinase in CML.	Cytidine Triphosphate	41-44	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	118-125
24136823-2	2013	The N-terminal nuclear localization signal (NLS) in CTP:phosphocholine cytidylyltransferase (CCT)alpha is removed during apoptosis but the caspase(s) involved and the contribution to suppression of the CDP-choline pathway is unresolved.	Cytidine Triphosphate	52-55	phosphate cytidylyltransferase 1A, choline	Homo sapiens	93-102
24721239-8	2014	In addition, both immunizations of CTP-HBcAg18-27-Tapasin led to significant decreases in serum HBsAg and HBV DNA levels compared to those in the CTP-HBcAg18-27 group.	Cytidine Triphosphate	35-38	TAP binding protein	Homo sapiens	50-57
24721239-8	2014	In addition, both immunizations of CTP-HBcAg18-27-Tapasin led to significant decreases in serum HBsAg and HBV DNA levels compared to those in the CTP-HBcAg18-27 group.	Cytidine Triphosphate	146-149	TAP binding protein	Homo sapiens	50-57
24008161-11	2013	CONCLUSIONS: Our study uncovered a fundamental difference in CTP biosynthesis between SMCs and ECs during vascular remodeling, which provided a novel strategy by using cyclopentenyl cytosine or other CTPS1 inhibitors to selectively block SMC proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury.	Cytidine Triphosphate	61-64	CTP synthase 1	Rattus norvegicus	200-205
23970552-1	2013	In the yeast Saccharomyces cerevisiae, the DGK1-encoded diacylglycerol kinase catalyzes the CTP-dependent phosphorylation of diacylglycerol to form phosphatidate.	Cytidine Triphosphate	92-95	diacylglycerol kinase	Saccharomyces cerevisiae S288C	43-47
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	Cytidine Triphosphate	171-195	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	106-132
23872271-2	2013	In Arabidopsis, pect1-4 mutants exhibit reduced cellular phosphatidylethanolamine levels owing to reduced CTP:phosphorylethanolamine cytidylyltransferase (PECT; EC 2.7.7.14) activity.	Cytidine Triphosphate	106-109	phosphorylethanolamine cytidylyltransferase 1	Arabidopsis thaliana	16-21
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	Cytidine Triphosphate	171-195	mucin 1, cell surface associated	Homo sapiens	320-324
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	Cytidine Triphosphate	171-195	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	368-371
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	Cytidine Triphosphate	171-195	mucin 1, cell surface associated	Homo sapiens	372-376
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	Cytidine Triphosphate	197-200	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	106-132
23623749-2	2013	A prevailing view is that only one CDP-DAG synthase named Cds1 is present in both the endoplasmic reticulum (ER) and mitochondrial inner membrane (IM) and mediates generation of CDP-DAG from phosphatidic acid (PA) and CTP.	Cytidine Triphosphate	218-221	phosphatidate cytidylyltransferase	Saccharomyces cerevisiae S288C	58-62
23370473-11	2013	CONCLUSIONS: A significant correlation exists between CTP measures and EGFR overexpression in head and neck squamous cell carcinomas, suggesting an association between certain imaging findings and molecular biomarkers.	Cytidine Triphosphate	54-57	epidermal growth factor receptor	Homo sapiens	71-75
24471092-6	2012	Moreover, oral administration of CTP prevented UVB-induced MMP-3 and -13 activities as well as MMP-2 and -9 expressions.	Cytidine Triphosphate	33-36	matrix metallopeptidase 3	Mus musculus	59-72
23433227-10	2013	Immunohistochemically, both Ctp-treated and Ctp/HA-treated groups had significantly increased type II collagen-positive chondrocytes at the fifth week after the surgery, although the numbers of matrix metalloproteinase-13-positive chondrocytes were not affected.	Cytidine Triphosphate	28-31	collagenase 3	Oryctolagus cuniculus	194-221
23433227-10	2013	Immunohistochemically, both Ctp-treated and Ctp/HA-treated groups had significantly increased type II collagen-positive chondrocytes at the fifth week after the surgery, although the numbers of matrix metalloproteinase-13-positive chondrocytes were not affected.	Cytidine Triphosphate	44-47	collagenase 3	Oryctolagus cuniculus	194-221
23637697-14	2013	CONCLUSIONS: Initial "TTP map-defect" of CTP could accurately predict HT risk including PH2 risk and identify low-risk patients even in the delayed period.	Cytidine Triphosphate	41-44	polyhomeotic homolog 2	Homo sapiens	88-91
23643075-3	2013	The mice of 4 groups were intramuscularly injected with the fusion protein CTP-HBcAg18-27;-Tapasin, CTP-HBcAg18-27;, HBcAg18-27;-Tapasin (50 mug) and normal saline, respectively.	Cytidine Triphosphate	75-78	TAP binding protein	Mus musculus	91-98
23643075-6	2013	RESULTS: CTP-HBcAg18-27;-Tapasin not only induced significantly T lymphocyte proliferation, but also increased the production of cytokines (IFN-gamma, IL-2) compared with CTP-HBcAg18-27; or HBcAg18-27;-Tapasin alone or normal saline.	Cytidine Triphosphate	9-12	TAP binding protein	Mus musculus	25-32
23643075-6	2013	RESULTS: CTP-HBcAg18-27;-Tapasin not only induced significantly T lymphocyte proliferation, but also increased the production of cytokines (IFN-gamma, IL-2) compared with CTP-HBcAg18-27; or HBcAg18-27;-Tapasin alone or normal saline.	Cytidine Triphosphate	9-12	interferon gamma	Mus musculus	140-149
23643075-6	2013	RESULTS: CTP-HBcAg18-27;-Tapasin not only induced significantly T lymphocyte proliferation, but also increased the production of cytokines (IFN-gamma, IL-2) compared with CTP-HBcAg18-27; or HBcAg18-27;-Tapasin alone or normal saline.	Cytidine Triphosphate	9-12	interleukin 2	Mus musculus	151-155
23643075-6	2013	RESULTS: CTP-HBcAg18-27;-Tapasin not only induced significantly T lymphocyte proliferation, but also increased the production of cytokines (IFN-gamma, IL-2) compared with CTP-HBcAg18-27; or HBcAg18-27;-Tapasin alone or normal saline.	Cytidine Triphosphate	9-12	TAP binding protein	Mus musculus	202-209
23643075-7	2013	Moreover, CTP-HBcAg18-27;-Tapasin fusion protein increased significantly the percentages of IFN-gamma(+);CD8(+); T cells.	Cytidine Triphosphate	10-13	TAP binding protein	Mus musculus	26-33
23643075-7	2013	Moreover, CTP-HBcAg18-27;-Tapasin fusion protein increased significantly the percentages of IFN-gamma(+);CD8(+); T cells.	Cytidine Triphosphate	10-13	interferon gamma	Mus musculus	92-101
22859289-21	2013	Quantitative CTP revealed significantly reduced CBF and prolonged MTT for DCI, permanent neurologic deficits, and infarction.	Cytidine Triphosphate	13-16	CCAAT enhancer binding protein zeta	Homo sapiens	48-51
23404087-4	2013	Scores were allocated to the time-to-peak (TTP) parameter of CTP using the Alberta stroke program early computed tomography scoring (ASPECTS) scale.	Cytidine Triphosphate	61-64	ZFP36 ring finger protein	Homo sapiens	43-46
23433161-5	2013	RESULTS: The activity of caspase-1 in 1 and 3 microg/ml CTP groups were (9.29 +- 0.30) and (8.67 +- 0.59) micromol/ml respectively which were both significantly increased compared to that (7.42 +- 0.59) micromol/ml in the control group (P &lt; 0.05) after 8 h exposure, but there was no significant difference in the activity of LDH and levels of IL-1beta in the cell culture media among the CTP and control groups.	Cytidine Triphosphate	56-59	caspase 1	Homo sapiens	25-34
23433161-5	2013	RESULTS: The activity of caspase-1 in 1 and 3 microg/ml CTP groups were (9.29 +- 0.30) and (8.67 +- 0.59) micromol/ml respectively which were both significantly increased compared to that (7.42 +- 0.59) micromol/ml in the control group (P &lt; 0.05) after 8 h exposure, but there was no significant difference in the activity of LDH and levels of IL-1beta in the cell culture media among the CTP and control groups.	Cytidine Triphosphate	56-59	interleukin 1 beta	Homo sapiens	347-355
23433161-5	2013	RESULTS: The activity of caspase-1 in 1 and 3 microg/ml CTP groups were (9.29 +- 0.30) and (8.67 +- 0.59) micromol/ml respectively which were both significantly increased compared to that (7.42 +- 0.59) micromol/ml in the control group (P &lt; 0.05) after 8 h exposure, but there was no significant difference in the activity of LDH and levels of IL-1beta in the cell culture media among the CTP and control groups.	Cytidine Triphosphate	392-395	caspase 1	Homo sapiens	25-34
23433161-7	2013	CONCLUSION: CTP treatment induced early increase in caspase-1 activity followed by the increase in LDH activity and IL-1 levels, indicative of pyroptosis in human bronchial epithelial cells.	Cytidine Triphosphate	12-15	caspase 1	Homo sapiens	52-61
23433161-7	2013	CONCLUSION: CTP treatment induced early increase in caspase-1 activity followed by the increase in LDH activity and IL-1 levels, indicative of pyroptosis in human bronchial epithelial cells.	Cytidine Triphosphate	12-15	interleukin 1 beta	Homo sapiens	116-120
24471092-6	2012	Moreover, oral administration of CTP prevented UVB-induced MMP-3 and -13 activities as well as MMP-2 and -9 expressions.	Cytidine Triphosphate	33-36	matrix metallopeptidase 2	Mus musculus	95-107
22285573-7	2012	The Km (muM) values were 22.13+-1.11 (ATP), 21.94+-3.88 (CTP), 21.27+-1.23 (GTP), and 9.91+-0.30 (UTP), indicating low substrate affinity.	Cytidine Triphosphate	57-60	latexin	Homo sapiens	8-11
22842000-4	2012	The murine and human P2X3 receptors were heterologously expressed in cells of the CHO line, and nucleotide-gated currents were stimulated by CTP and ATP, respectively.	Cytidine Triphosphate	141-144	purinergic receptor P2X 3	Homo sapiens	21-25
22842000-6	2012	When subthreshold CTP or ATP was added to the bath to exert the high-affinity desensitization of P2X3 receptors, both spider toxins strongly enhanced the desensitizing action of the ambient nucleotides.	Cytidine Triphosphate	18-21	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	97-101
22842000-7	2012	At the concentration of 50nM, PT1 and PT2 elicited 3-4-fold decrease in the IC(50) dose of ambient CTP or ATP.	Cytidine Triphosphate	99-102	zinc finger protein 77	Homo sapiens	30-33
22428658-7	2012	NEMO binding domain peptide (NBD, TALDWSWLQTE) fused with a cell permeable peptide CTP (YGRRARRRARR), CTP-NBD, was most potent in inhibiting NFkappaB activity in cells.	Cytidine Triphosphate	83-86	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Rattus norvegicus	0-4
22428658-7	2012	NEMO binding domain peptide (NBD, TALDWSWLQTE) fused with a cell permeable peptide CTP (YGRRARRRARR), CTP-NBD, was most potent in inhibiting NFkappaB activity in cells.	Cytidine Triphosphate	102-105	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Rattus norvegicus	0-4
22428658-8	2012	Colon-targeted CTP-NBD, but not colon-targeted NBD and CTP-NBD in an enteric capsule, ameliorated the colonic injury, which was in parallel with decrease in MPO activity and the levels of inflammatory mediators.	Cytidine Triphosphate	15-18	myeloperoxidase	Rattus norvegicus	157-160
23074967-2	2012	Cytidine triphosphate (CTP):phosphocholine cytidylyltransferase alpha (CTalpha) regulates the primary pathway of PC biosynthesis in the liver.	Cytidine Triphosphate	0-21	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	71-78
23074967-2	2012	Cytidine triphosphate (CTP):phosphocholine cytidylyltransferase alpha (CTalpha) regulates the primary pathway of PC biosynthesis in the liver.	Cytidine Triphosphate	23-26	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	71-78
22410290-13	2012	Quantitative PCR analysis and immunohistochemical study revealed that CTP abolished the increased NGF and decreased Sema3A levels induced by acetone treatment.	Cytidine Triphosphate	70-73	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	116-122
22804928-5	2012	The ELISA assay was utilized to measure the levels of TNF-alpha in the supernatant of CTP group and co-culture group.	Cytidine Triphosphate	86-89	tumor necrosis factor	Homo sapiens	54-63
22799021-6	2012	For examples, attachment of the C-terminal peptide (CTP) of the human chorionic gonadotropin beta subunit or a sequence containing potential glycosylation sites to either subunit of FSH, creation of a single chain containing the alpha and beta subunits of FSH combined with CTP or N-linked glycosylation signal sequence as a linker, or fusion of the Fc domain of IgGi to FSH.	Cytidine Triphosphate	52-55	chorionic gonadotropin subunit beta 5	Homo sapiens	70-105
22119930-7	2012	Treatment with G-CSF also reduced CTP scores in group A by a median of 33.3% compared with an increase of 7.1% in group B (P = .001), along with MELD (median reduction of 15.3% compared with an increase of 11.7% in group B; P = .008) and SOFA scores (median reduction of 50% compared with an increase of 50% in group B; P = .001).	Cytidine Triphosphate	34-37	colony stimulating factor 3	Homo sapiens	15-20
22119930-10	2012	CONCLUSIONS: G-CSF therapy more than doubles the percentage of patients with ACLF who survive for 2 months; it also significantly reduces CTP, MELD, and SOFA scores and prevents the development of sepsis, hepatorenal syndrome, and hepatic encephalopathy.	Cytidine Triphosphate	138-141	colony stimulating factor 3	Homo sapiens	13-18
22116619-5	2012	METHODS AND RESULTS: We generated a myocardial specific Pitx2 knockout model (cTP mice).	Cytidine Triphosphate	78-81	paired-like homeodomain transcription factor 2	Mus musculus	56-61
22116619-6	2012	cTP embryos present several features of Pitx2 null, including right atrial isomerism with bilateral SANs and symmetric atrial entrance of the systemic veins.	Cytidine Triphosphate	0-3	paired-like homeodomain transcription factor 2	Mus musculus	40-45
22122229-5	2012	As opposed to GTP, ITP, XTP and ATP, the pyrimidine nucleotides UTP and CTP were found to be sGC substrates in the presence of Mn(2+).	Cytidine Triphosphate	72-75	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	93-96
21893514-0	2011	Characterization of Arabidopsis CTP:3-deoxy-D-manno-2-octulosonate cytidylyltransferase (CMP-KDO synthetase), the enzyme that activates KDO during rhamnogalacturonan II biosynthesis.	Cytidine Triphosphate	32-35	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	89-107
22146502-1	2011	BACKGROUND: Quantitative myocardial CT perfusion (CTP) is susceptible to beam-hardening (BH) artifact from conventional single-energy (kVp) CT (SECT) scanning, which can mimic perfusion deficits.	Cytidine Triphosphate	50-53	SECT	Sus scrofa	144-148
21893514-4	2011	Here, we characterized Arabidopsis CTP:KDO cytidylyltransferase (CMP-KDO synthetase; CKS), the enzyme activating KDO as a nucleotide sugar prior to its incorporation into RG-II.	Cytidine Triphosphate	35-38	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	65-83
21893514-4	2011	Here, we characterized Arabidopsis CTP:KDO cytidylyltransferase (CMP-KDO synthetase; CKS), the enzyme activating KDO as a nucleotide sugar prior to its incorporation into RG-II.	Cytidine Triphosphate	35-38	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	85-88
21084896-2	2010	We investigated the reliability of CTP cerebral blood flow (CTP-CBF) with 320-detector row CT by comparing findings with O-positron emission tomography (PET-CBF).	Cytidine Triphosphate	35-38	CCAAT enhancer binding protein zeta	Homo sapiens	64-67
21920316-2	2011	Here, we identified a protein complex composed of the tumor suppressor anastral spindle 2 (Ana2), a dynein light-chain protein Cut up (Ctp), and Mushroom body defect (Mud), which regulates mitotic spindle orientation.	Cytidine Triphosphate	135-138	anastral spindle 2	Drosophila melanogaster	91-95
21920316-4	2011	The centriolar protein Ana2 anchors Ctp to centrioles during ACD.	Cytidine Triphosphate	36-39	anastral spindle 2	Drosophila melanogaster	23-27
21410410-7	2011	hCG isoform analysis in the urine sample revealed that approximately 87.5% of the immunoreactive hCG lacked the beta-subunit C-terminal peptide (CTP).	Cytidine Triphosphate	145-148	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
21410410-7	2011	hCG isoform analysis in the urine sample revealed that approximately 87.5% of the immunoreactive hCG lacked the beta-subunit C-terminal peptide (CTP).	Cytidine Triphosphate	145-148	chorionic gonadotropin subunit beta 5	Homo sapiens	97-100
21410410-9	2011	The majority of the total hCG contained a degraded form of beta-subunit that lacks the CTP.	Cytidine Triphosphate	87-90	chorionic gonadotropin subunit beta 5	Homo sapiens	26-29
21444658-7	2011	Mutant cycle analyses showed that the modulation effects of ATP and cytidine triphosphate on wild-type CLC-1 and the V634F mutant were nonadditive, suggesting that the side chain of amino acid at position 634 interacts with the base moiety of the nucleotide.	Cytidine Triphosphate	68-89	chloride voltage-gated channel 1	Homo sapiens	103-108
20734243-5	2010	RESULTS: Successful use of CTP to aid in decision to proceed with neurointervention in acute basilar artery occlusion and confirm its resolution after mechanical clot retrieval.	Cytidine Triphosphate	27-30	activation induced cytidine deaminase	Homo sapiens	34-37
20933549-9	2010	The kinetic properties of the enzyme with respect to UTP, GTP, and CTP suggested that glycerokinase exhibited negative cooperativity as double reciprocal plots showed a biphasic response to increasing nucleoside triphosphate concentrations.	Cytidine Triphosphate	67-70	glycerol kinase	Homo sapiens	86-99
21084896-2	2010	We investigated the reliability of CTP cerebral blood flow (CTP-CBF) with 320-detector row CT by comparing findings with O-positron emission tomography (PET-CBF).	Cytidine Triphosphate	60-63	CCAAT enhancer binding protein zeta	Homo sapiens	64-67
21084896-5	2010	RESULTS: Although mean CTP-CBF values were approximately 30% lower than mean PET-CBF values, the mean ischemic-to-nonischemic CBF ratios of CTP and PET were almost identical (P = 0.804).	Cytidine Triphosphate	23-26	CCAAT enhancer binding protein zeta	Homo sapiens	27-30
21084896-6	2010	Regression analysis showed a significant correlation between CTP-CBF and PET-CBF values for each patient (r = 0.52-0.85, P &lt; 0.001).	Cytidine Triphosphate	61-64	CCAAT enhancer binding protein zeta	Homo sapiens	65-68
21084896-6	2010	Regression analysis showed a significant correlation between CTP-CBF and PET-CBF values for each patient (r = 0.52-0.85, P &lt; 0.001).	Cytidine Triphosphate	61-64	CCAAT enhancer binding protein zeta	Homo sapiens	77-80
20569198-10	2010	In this new state, adenosine nucleotide binding is competed for by other nucleotides (CTP, GTP and AMP-PNP), although ATP and ADP, but not the other nucleotides, partially stabilize the protein against spontaneous loss of aconitase activity when incubated at 37 degrees C. A mutant IRP-1(C437S) lacking aconitase activity shows only one ATP-binding site and lacks co-operativity.	Cytidine Triphosphate	86-89	aconitase 1	Homo sapiens	282-287
20739275-3	2010	Kinetic analysis demonstrated that both hCTPS1 and hCTPS2 were maximally active at physiological concentrations of ATP, GTP, and glutamine, whereas the K(m) and IC(50) values for the substrate UTP and the product CTP, respectively, were close to their physiological concentrations, indicating that the intracellular concentrations of UTP and CTP may precisely regulate hCTPS activity.	Cytidine Triphosphate	41-44	CTP synthase 2	Homo sapiens	51-57
19683078-3	2009	Detailed kinetic studies found that this PPCS follows a similar Bi Uni Uni Bi Ping Pong mechanism as previously described for the E. faecalis PPCS, except that the human enzyme can use both ATP and CTP with similar affinity.	Cytidine Triphosphate	198-201	phosphopantothenoylcysteine synthetase	Homo sapiens	41-45
20510246-7	2010	DHX9 lacks base-selective contacts and forms an unspecific but important stacking interaction with the base of the bound nucleotide, and our biochemical analysis confirms that the protein can hydrolyze ATP, guanosine 5"-triphosphate, cytidine 5"-triphosphate, and uridine 5"-triphosphate.	Cytidine Triphosphate	234-258	DExH-box helicase 9	Homo sapiens	0-4
20416172-7	2010	The sRANKL/OPG ratio was closely related to levels of TRAP-5b (r=0.512, p&lt;0.05) and CTP-I (r=0.481, p&lt;0.05) in MM patients.	Cytidine Triphosphate	87-90	TNF receptor superfamily member 11b	Homo sapiens	11-14
20518344-4	2010	HeLa cells pretreated with CTP-SOD showed a significantly improved survival against the pyrogallol-induced oxidative stress, suggesting CTP-SOD could cross the cell membrane more efficiently and protect cells from oxidative stress.	Cytidine Triphosphate	27-30	superoxide dismutase 1	Homo sapiens	31-34
20518344-4	2010	HeLa cells pretreated with CTP-SOD showed a significantly improved survival against the pyrogallol-induced oxidative stress, suggesting CTP-SOD could cross the cell membrane more efficiently and protect cells from oxidative stress.	Cytidine Triphosphate	27-30	superoxide dismutase 1	Homo sapiens	140-143
20518344-4	2010	HeLa cells pretreated with CTP-SOD showed a significantly improved survival against the pyrogallol-induced oxidative stress, suggesting CTP-SOD could cross the cell membrane more efficiently and protect cells from oxidative stress.	Cytidine Triphosphate	136-139	superoxide dismutase 1	Homo sapiens	31-34
20518344-4	2010	HeLa cells pretreated with CTP-SOD showed a significantly improved survival against the pyrogallol-induced oxidative stress, suggesting CTP-SOD could cross the cell membrane more efficiently and protect cells from oxidative stress.	Cytidine Triphosphate	136-139	superoxide dismutase 1	Homo sapiens	140-143
20304153-11	2010	In period 2, the ROC curve for CTP was 0.680 and for MELD, 0.718 (P = .4).	Cytidine Triphosphate	31-34	period circadian regulator 2	Homo sapiens	3-11
19683078-3	2009	Detailed kinetic studies found that this PPCS follows a similar Bi Uni Uni Bi Ping Pong mechanism as previously described for the E. faecalis PPCS, except that the human enzyme can use both ATP and CTP with similar affinity.	Cytidine Triphosphate	198-201	phosphopantothenoylcysteine synthetase	Homo sapiens	142-146
19683078-4	2009	One significant difference for human PPCS catalysis with respect to ATP and CTP is that the enzyme shows cooperative binding of ATP, measured as a Hill constant of 1.7.	Cytidine Triphosphate	76-79	phosphopantothenoylcysteine synthetase	Homo sapiens	37-41
19683078-5	2009	PPCS catalysis under CTP conditions displayed Michaelis constants of 265 microM, 57 microM, and 16 microM for CTP, PPA, and cysteine, respectively, with a kcat of 0.53+/-0.01 s(-1) for the reaction.	Cytidine Triphosphate	21-24	phosphopantothenoylcysteine synthetase	Homo sapiens	0-4
19683078-5	2009	PPCS catalysis under CTP conditions displayed Michaelis constants of 265 microM, 57 microM, and 16 microM for CTP, PPA, and cysteine, respectively, with a kcat of 0.53+/-0.01 s(-1) for the reaction.	Cytidine Triphosphate	110-113	phosphopantothenoylcysteine synthetase	Homo sapiens	0-4
19683078-7	2009	Oxygen transfer studies found that 18O from [carboxyl-18O] phosphopantothenate is incorporated into the AMP or CMP produced during PPCS catalysis, consistent with the formation of a phosphopantothenoyl cytidylate or phosphopantothenoyl adenylate intermediate, supporting similar catalytic mechanisms under both CTP and ATP conditions.	Cytidine Triphosphate	311-314	phosphopantothenoylcysteine synthetase	Homo sapiens	131-135
19357031-7	2009	Then, CTP parameters were determined whether they were correlated with MVD and VEGF using Pearsonos correlation coefficient.	Cytidine Triphosphate	6-9	vascular endothelial growth factor A	Oryctolagus cuniculus	79-83
19783652-2	2009	The CCT-catalyzed transfer of a cytidylyl group from CTP to phosphocholine to form CDP-choline is regulated by a membrane lipid-dependent mechanism imparted by its C-terminal membrane binding domain.	Cytidine Triphosphate	53-56	cut like homeobox 1	Homo sapiens	83-86
19667100-2	2009	The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway.	Cytidine Triphosphate	43-46	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	22-26
19667100-2	2009	The A. thaliana genes CCT1 and CCT2 encode CTP:phosphorylcholine cytidylyltransferases (CCTs; EC 2.7.7.15), which regulate PC biosynthesis via the CDP-choline pathway.	Cytidine Triphosphate	43-46	phosphorylcholine cytidylyltransferase2	Arabidopsis thaliana	31-35
19374912-2	2009	Lui, C. Vandenboom &amp; E. Chedid (2008), The complex trial protocol (CTP): a new, countermeasure-resistant, accurate P300-based method for detection of concealed information.	Cytidine Triphosphate	71-74	E1A binding protein p300	Homo sapiens	119-123
19902973-1	2009	Bacterial phosphopantothenolycysteine synthetase (PPCS) catalyzes the formation of phosphopantothenoylcysteine (PPC) from (R)-phosphopantothenate, l-cysteine, and cytidine-5"-triphosphate (CTP) and has been shown to be essential for growth and survival.	Cytidine Triphosphate	163-187	phosphopantothenoylcysteine synthetase	Homo sapiens	50-54
19902973-1	2009	Bacterial phosphopantothenolycysteine synthetase (PPCS) catalyzes the formation of phosphopantothenoylcysteine (PPC) from (R)-phosphopantothenate, l-cysteine, and cytidine-5"-triphosphate (CTP) and has been shown to be essential for growth and survival.	Cytidine Triphosphate	189-192	phosphopantothenoylcysteine synthetase	Homo sapiens	50-54
19804726-2	2009	To understand the myosin-ATP interaction and in particular, the interactions with the base, we have used molecular dynamics simulations to model the interactions of myosin with ATP, CTP, UTP, aza-ATP, ITP, and GTP (in decreasing order of effectiveness as a substrate for the generation of motility) docked at the active site.	Cytidine Triphosphate	182-185	myosin heavy chain 14	Homo sapiens	165-171
19007959-3	2009	Following phosphatase treatment, the dinucleotides GpC and ApC in a 4:1 ratio were identified by nearest neighbor analysis in which (32)P was transferred from [alpha-(32)P]CTP to initiating purine nucleotides.	Cytidine Triphosphate	172-175	APC regulator of WNT signaling pathway	Homo sapiens	59-62
19141610-4	2009	Pct1 converts phosphocholine and CTP to CDP-choline and pyrophosphate.	Cytidine Triphosphate	33-36	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	0-4
19109895-5	2008	DHX29 binds 40S subunits and hydrolyzes ATP, GTP, UTP, and CTP.	Cytidine Triphosphate	59-62	DExH-box helicase 29	Homo sapiens	0-5
18439916-3	2008	The URA7 and URA8 genes encode CTP synthetase in S. cerevisiae, and the URA7 gene is responsible for the majority of CTP synthesized in vivo.	Cytidine Triphosphate	31-34	CTP synthase URA7	Saccharomyces cerevisiae S288C	4-8
18922025-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC).	Cytidine Triphosphate	93-117	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-39
18922025-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC).	Cytidine Triphosphate	93-117	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
18922025-1	2008	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC).	Cytidine Triphosphate	0-3	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
18922025-6	2008	CCT1 exhibited a V max of 23904 nmol of CDP-choline min (-1) mg (-1) and apparent K m values for phosphocholine and CTP of 2.29 and 1.21 mM, respectively, in the presence of 20 muM PC/oleate vesicles.	Cytidine Triphosphate	116-119	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-4
18823418-0	2008	The Complex Trial Protocol (CTP): a new, countermeasure-resistant, accurate, P300-based method for detection of concealed information.	Cytidine Triphosphate	28-31	E1A binding protein p300	Homo sapiens	77-81
18976223-3	2008	The NTPase follows Michaelis-Menten kinetics in the range of investigated substrate concentrations, the apparent K(m) values for UTP, ITP, GTP, CTP, CDP, and ATP being 86, 25, 41, 150, 500, and 260 microM, respectively.	Cytidine Triphosphate	144-147	cancer-related nucleoside-triphosphatase homolog	Bos taurus	4-10
18439916-3	2008	The URA7 and URA8 genes encode CTP synthetase in S. cerevisiae, and the URA7 gene is responsible for the majority of CTP synthesized in vivo.	Cytidine Triphosphate	31-34	CTP synthase URA8	Saccharomyces cerevisiae S288C	13-17
18439916-6	2008	The URA7-encoded enzyme is phosphorylated by protein kinases A and C, and these phosphorylations stimulate CTP synthetase activity and increase cellular CTP levels and the utilization of the Kennedy pathway.	Cytidine Triphosphate	107-110	CTP synthase URA7	Saccharomyces cerevisiae S288C	4-8
18565758-9	2008	CAD of the RNase S-CDP and CTP complexes dissociates the S-peptide from the remaining S-protein/nucleotide complex; further dissociation of the S-protein/nucleotide complex fragments a covalent phosphate bond of the nucleotide with subsequent release of CMP.	Cytidine Triphosphate	27-30	vitronectin	Homo sapiens	86-95
18521893-10	2008	Most notable was that the CTP contained specialized muscle fibers expressing some unusual MHC isoforms (i.e., slow-tonic, alpha-cardiac, neonatal, and embryonic).	Cytidine Triphosphate	26-29	major histocompatibility complex, class I, C	Homo sapiens	90-93
18565758-9	2008	CAD of the RNase S-CDP and CTP complexes dissociates the S-peptide from the remaining S-protein/nucleotide complex; further dissociation of the S-protein/nucleotide complex fragments a covalent phosphate bond of the nucleotide with subsequent release of CMP.	Cytidine Triphosphate	27-30	vitronectin	Homo sapiens	144-153
18565758-10	2008	Despite a solution binding constant favoring the S-protein/S-peptide complex, CDP/CTP remains electrostatically bound to the S-protein in the gas-phase dissociation experiment.	Cytidine Triphosphate	82-85	vitronectin	Homo sapiens	125-134
18477471-0	2008	Crystal structure of Sulfolobus acidocaldarius aspartate carbamoyltransferase in complex with its allosteric activator CTP.	Cytidine Triphosphate	119-122	ATZ20_RS01680	Sulfolobus acidocaldarius	47-77
18477471-3	2008	The ATCase from the thermoacidophilic archaeon Sulfolobus acidocaldarius, for example, is strongly activated by its metabolic pathway"s end product CTP, in contrast with Escherichia coli ATCase which is inhibited by CTP.	Cytidine Triphosphate	148-151	ATZ20_RS01680	Sulfolobus acidocaldarius	4-10
18477471-3	2008	The ATCase from the thermoacidophilic archaeon Sulfolobus acidocaldarius, for example, is strongly activated by its metabolic pathway"s end product CTP, in contrast with Escherichia coli ATCase which is inhibited by CTP.	Cytidine Triphosphate	148-151	ATZ20_RS01680	Sulfolobus acidocaldarius	187-193
18477471-3	2008	The ATCase from the thermoacidophilic archaeon Sulfolobus acidocaldarius, for example, is strongly activated by its metabolic pathway"s end product CTP, in contrast with Escherichia coli ATCase which is inhibited by CTP.	Cytidine Triphosphate	216-219	ATZ20_RS01680	Sulfolobus acidocaldarius	4-10
18477471-3	2008	The ATCase from the thermoacidophilic archaeon Sulfolobus acidocaldarius, for example, is strongly activated by its metabolic pathway"s end product CTP, in contrast with Escherichia coli ATCase which is inhibited by CTP.	Cytidine Triphosphate	216-219	ATZ20_RS01680	Sulfolobus acidocaldarius	187-193
18324728-6	2008	Furthermore, the sensitivity and specificity of this readily accessible procedure was assessed by monitoring the in-gel activity of NDPK using different concentrations of GTP and CTP as well as deoxynucleoside triphosphates.	Cytidine Triphosphate	179-182	cytidine/uridine monophosphate kinase 2	Homo sapiens	132-136
18458075-4	2008	We show that Dgk1p is a unique diacylglycerol kinase that uses CTP, instead of ATP, to generate phosphatidate.	Cytidine Triphosphate	63-66	diacylglycerol kinase	Saccharomyces cerevisiae S288C	13-18
18458076-7	2008	The DGK1-encoded enzyme had a pH optimum at 7.0-7.5, required Ca(2+) or Mg(2+) ions for activity, was potently inhibited by N-ethylmaleimide, and was labile at temperatures above 40 degrees C. The enzyme exhibited positive cooperative (Hill number = 2.5) kinetics with respect to diacylglycerol (apparent K(m) = 6.5 mol %) and saturation kinetics with respect to CTP (apparent K(m) = 0.3 mm).	Cytidine Triphosphate	363-366	diacylglycerol kinase	Saccharomyces cerevisiae S288C	4-8
18215061-1	2008	Cytidine-5"-triphosphate synthase (CTPS) catalyzes the formation of cytidine triphosphate (CTP) from glutamine, uridine 5"-triphosphate (UTP), and adenosine 5"-triphosphate (ATP).	Cytidine Triphosphate	68-89	CTP synthase 1	Homo sapiens	0-33
18215061-1	2008	Cytidine-5"-triphosphate synthase (CTPS) catalyzes the formation of cytidine triphosphate (CTP) from glutamine, uridine 5"-triphosphate (UTP), and adenosine 5"-triphosphate (ATP).	Cytidine Triphosphate	68-89	CTP synthase 1	Homo sapiens	35-39
18215061-1	2008	Cytidine-5"-triphosphate synthase (CTPS) catalyzes the formation of cytidine triphosphate (CTP) from glutamine, uridine 5"-triphosphate (UTP), and adenosine 5"-triphosphate (ATP).	Cytidine Triphosphate	35-38	CTP synthase 1	Homo sapiens	0-33
17959832-1	2008	The nucleoplasmic reticulum (NR), a nuclear membrane network implicated in signaling and transport, is formed by the biosynthetic and membrane curvature-inducing properties of the rate-limiting enzyme in phosphatidylcholine synthesis, CTP:phosphocholine cytidylyltransferase (CCT) alpha.	Cytidine Triphosphate	235-238	phosphate cytidylyltransferase 1A, choline	Homo sapiens	276-286
17704167-6	2007	Values in the region of 50-110 A(2) are estimated for the effective cross-sectional shape changes on the insertion and conductance transitions of alamethicin, and on the activation of CTP:phosphocholine cytidylyltransferase or rhodopsin in lipid membranes.	Cytidine Triphosphate	184-187	rhodopsin	Homo sapiens	227-236
17804406-0	2007	Calmodulin binds and stabilizes the regulatory enzyme, CTP: phosphocholine cytidylyltransferase.	Cytidine Triphosphate	55-58	calmodulin 1	Homo sapiens	0-10
18047786-4	2007	MEP cytidyltransferase (IspD), the third-step enzyme of the pathway, catalyzes MEP and CTP to form 4-diphosphocytidyl-2-C-methylerythritol (CDP-ME) and PPi.	Cytidine Triphosphate	87-90	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	Mycobacterium tuberculosis H37Rv	24-28
17764847-5	2007	Among guanine, cytosine and their related nucleotides, only triphosphate nucleotides (CTP and GTP) exhibited potent UGT inhibition, although the effect of GTP was weak.	Cytidine Triphosphate	86-89	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	116-119
17641000-7	2007	However, both in vivo potency and half-life of EPO-CTP were significantly enhanced.	Cytidine Triphosphate	51-54	erythropoietin	Homo sapiens	47-50
17005674-6	2006	Furthermore, Delta97nsP4 is unable to transfer other nucleotides (UTP, CTP, GTP, and dATP) to the acceptor RNA in the absence or presence of other nucleotides.	Cytidine Triphosphate	71-74	solute carrier family 10 member 4	Homo sapiens	13-24
17056809-2	2006	In rats, dietary CDP-choline is rapidly metabolized into cytidine and choline; the cytidine is then readily converted to uridine, which enters the brain and, via conversion to UTP and CTP, increases brain levels of membrane phosphatides.	Cytidine Triphosphate	184-187	cut-like homeobox 1	Rattus norvegicus	17-20
16923818-0	2006	Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site.	Cytidine Triphosphate	106-109	dolichol kinase	Homo sapiens	6-21
16923818-1	2006	Dolichol kinase (DK) catalyzes the CTP-dependent phosphorylation of dolichol in the biosynthesis de novo and possibly the recycling of dolichyl monophosphate in yeast and mammals.	Cytidine Triphosphate	35-38	dolichol kinase	Saccharomyces cerevisiae S288C	0-15
16923818-1	2006	Dolichol kinase (DK) catalyzes the CTP-dependent phosphorylation of dolichol in the biosynthesis de novo and possibly the recycling of dolichyl monophosphate in yeast and mammals.	Cytidine Triphosphate	35-38	dolichol kinase	Saccharomyces cerevisiae S288C	17-19
17574211-3	2007	STD NMR experiments of the protein-enriched Sepharose matrix in the presence of a binding ligand (cytidine 5"-triphosphate, CTP) and a non-binding ligand (alpha/beta-glucose) clearly show that CTP binds to the immobilised enzyme, whereas glucose has no affinity.	Cytidine Triphosphate	98-122	solute carrier family 25 member 1	Homo sapiens	193-196
17691910-4	2007	CPEC-TP is a non competitive inhibitor of cytidine-5"-triphosphate synthetase (CTP-synthetase), an important enzyme in the formation of CTP.	Cytidine Triphosphate	79-82	CTP synthase 1	Homo sapiens	42-77
17483456-5	2007	We demonstrate that purified cryopyrin binds ATP, dATP, and ATP-agarose, but not CTP, GTP, or UTP, and exhibits ATPase activity.	Cytidine Triphosphate	81-84	NLR family pyrin domain containing 3	Homo sapiens	29-38
17092639-2	2007	CGbeta genes from the human being and horse have evolved from ancestral luteinizing hormone (LH) beta genes by different pathways that involve deletions that change the reading frames and yield a CTP.	Cytidine Triphosphate	196-199	chorionic gonadotropin subunit beta 3	Homo sapiens	0-6
17092639-3	2007	Here we further review our previous analysis, aimed at determining whether LHbeta genes in non-primate, non-equid species inherently possess DNA sequences that encode CTP-like domains.	Cytidine Triphosphate	167-170	luteinizing hormone subunit beta	Homo sapiens	75-81
17092639-4	2007	In multiple mammalian species, simple frame-shift mutations using either the human or equine CGbeta gene as a model can be used to construct LHbeta analogs with putative CTP domains.	Cytidine Triphosphate	170-173	chorionic gonadotropin subunit beta 3	Homo sapiens	93-99
17092639-4	2007	In multiple mammalian species, simple frame-shift mutations using either the human or equine CGbeta gene as a model can be used to construct LHbeta analogs with putative CTP domains.	Cytidine Triphosphate	170-173	lutropin/choriogonadotropin subunit beta	Equus caballus	141-147
17092639-5	2007	Furthermore, DNA sequences from mammalian LHbeta genes can be aligned to maximize similarity with CGbeta genes in order to devise more refined strategies for construction of CTP-bearing LHbeta analogs as exemplified in the bovine case.	Cytidine Triphosphate	174-177	luteinizing hormone subunit beta	Homo sapiens	42-48
17092639-5	2007	Furthermore, DNA sequences from mammalian LHbeta genes can be aligned to maximize similarity with CGbeta genes in order to devise more refined strategies for construction of CTP-bearing LHbeta analogs as exemplified in the bovine case.	Cytidine Triphosphate	174-177	chorionic gonadotropin subunit beta 3	Homo sapiens	98-104
17092639-5	2007	Furthermore, DNA sequences from mammalian LHbeta genes can be aligned to maximize similarity with CGbeta genes in order to devise more refined strategies for construction of CTP-bearing LHbeta analogs as exemplified in the bovine case.	Cytidine Triphosphate	174-177	luteinizing hormone subunit beta	Homo sapiens	186-192
17092639-6	2007	Thus, mammalian LHbeta genes have DNA sequences that can be potentially expressed in order to construct CTP-bearing glycoprotein hormone analogs.	Cytidine Triphosphate	104-107	luteinizing hormone subunit beta	Homo sapiens	16-22
17158078-7	2007	Of interest, dolphin LHbeta lacks carboxyl-terminal-peptides (CTP).	Cytidine Triphosphate	62-65	LHB	Tursiops truncatus	21-27
16868337-3	2006	Herein, we observed that PA103 reduced alveolar PtdCho levels, resulting in impaired lung biophysical activity, an effect partly attributed to caspase-dependent cleavage of the key PtdCho biosynthetic enzyme, CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha).	Cytidine Triphosphate	209-212	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	256-264
16527410-6	2006	CGbeta subunit is distinguished among the beta subunits because of the presence of a carboxyl-terminal peptide (CTP) bearing four O-linked oligosaccharide chains.	Cytidine Triphosphate	112-115	chorionic gonadotropin subunit beta 3	Homo sapiens	0-6
16644100-3	2006	Although the CGbeta subunit containing the CTP domain is expressed only in primates and equids, a CTP-like sequence exists in the untranslated region of the LHbeta gene of several mammalian species, including the bovine species.	Cytidine Triphosphate	43-46	chorionic gonadotropin subunit beta 3	Homo sapiens	13-19
16644100-3	2006	Although the CGbeta subunit containing the CTP domain is expressed only in primates and equids, a CTP-like sequence exists in the untranslated region of the LHbeta gene of several mammalian species, including the bovine species.	Cytidine Triphosphate	98-101	luteinizing hormone subunit beta	Homo sapiens	157-163
16644100-4	2006	The CTP encrypted in the bovine LHbeta DNA (designated as "boCTP") and the CTP derived from the human CGbeta subunit (denoted as "huCTP") served as a linker sequence in the design of bovine single-chain luteinizing hormone (LH) analogs.	Cytidine Triphosphate	4-7	lutropin subunit beta	Bos taurus	32-38
16644100-14	2006	Thus, an effective strategy to produce bioactive single-chain LH analogs in non-primate, non-equid species would be the mutatation of the LHbeta genes with the aim of expressing the cryptic CTP sequence as a spacer derived from the DNA of the same organism.	Cytidine Triphosphate	190-193	lutropin subunit beta	Bos taurus	138-144
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	4-7	diablo IAP-binding mitochondrial protein	Homo sapiens	19-23
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	4-7	diablo IAP-binding mitochondrial protein	Homo sapiens	24-30
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	4-7	diablo IAP-binding mitochondrial protein	Homo sapiens	40-44
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	4-7	diablo IAP-binding mitochondrial protein	Homo sapiens	40-44
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	4-7	X-linked inhibitor of apoptosis	Homo sapiens	156-160
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	45-48	diablo IAP-binding mitochondrial protein	Homo sapiens	19-23
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	45-48	diablo IAP-binding mitochondrial protein	Homo sapiens	24-30
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	45-48	diablo IAP-binding mitochondrial protein	Homo sapiens	40-44
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	45-48	diablo IAP-binding mitochondrial protein	Homo sapiens	40-44
16466653-6	2006	The CTP-conjugated Smac/DIABLO peptide (Smac-CTP) was also shown to be much more efficient than Smac-PTD in the blockage of the antiapoptotic properties of XIAP, suggesting that cytoplasmic functional molecules can be more efficiently targeted by CTP-mediated delivery.	Cytidine Triphosphate	45-48	X-linked inhibitor of apoptosis	Homo sapiens	156-160
16636974-2	2006	In tethered human (h) gonadotropins, the carboxyl terminal peptide (CTP) of the choriogonadotropin (CG) beta subunit serves as an effective linker to enhance the secretion of the analogs compared to variants lacking the CTP.	Cytidine Triphosphate	68-71	chorionic gonadotropin subunit beta 3	Homo sapiens	80-108
16533898-6	2006	Furthermore, nearly all Mg-nucleotides were able to inhibit TRPM7 activity to varying degrees with the following rank in potency: ATP &gt; TTP &gt; CTP &gt; or = GTP &gt; or = UTP &gt; ITP approximately free Mg(2+) alone.	Cytidine Triphosphate	148-151	transient receptor potential cation channel subfamily M member 7	Homo sapiens	60-65
16636974-5	2006	This cryptic CTP (designated boCTP) was incorporated into the bovine LHbeta reading frame by deletion frame-shift mutations analogous to these that presumably occurred in primates and equids.	Cytidine Triphosphate	13-16	lutropin subunit beta	Bos taurus	69-75
16636974-11	2006	Thus, the hCGbeta CTP maintains pro-secretory determinants without inhibiting receptor activation when applied as a linker in tethered bovine LH, implying that these CTP features are preserved when the domain is incorporated into non-primate single chain analogs.	Cytidine Triphosphate	18-21	chorionic gonadotropin subunit beta 3	Homo sapiens	10-17
16636974-11	2006	Thus, the hCGbeta CTP maintains pro-secretory determinants without inhibiting receptor activation when applied as a linker in tethered bovine LH, implying that these CTP features are preserved when the domain is incorporated into non-primate single chain analogs.	Cytidine Triphosphate	166-169	chorionic gonadotropin subunit beta 3	Homo sapiens	10-17
16336632-3	2006	There are abnormalities in GTP, UTP and CTP concentrations in HPRT-deficient cells.	Cytidine Triphosphate	40-43	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	62-66
16179339-1	2005	In this work we showed that the human CTP synthetase genes, CTPS1 and CTPS2, were functional in Saccharomyces cerevisiae and complemented the lethal phenotype of the ura7Delta ura8Delta mutant lacking CTP synthetase activity.	Cytidine Triphosphate	38-41	CTP synthase 1	Homo sapiens	60-65
16179339-1	2005	In this work we showed that the human CTP synthetase genes, CTPS1 and CTPS2, were functional in Saccharomyces cerevisiae and complemented the lethal phenotype of the ura7Delta ura8Delta mutant lacking CTP synthetase activity.	Cytidine Triphosphate	38-41	CTP synthase 2	Homo sapiens	70-75
16179339-2	2005	The expression of the CTPS1- and CTPS2-encoded human CTP synthetase enzymes in the ura7Delta ura8Delta mutant was shown by immunoblot analysis of CTP synthetase proteins, the measurement of CTP synthetase activity, and the synthesis of CTP in vivo.	Cytidine Triphosphate	22-25	CTP synthase 2	Homo sapiens	33-38
16153613-5	2005	CDP-choline liposomes deliver the agent intact to the brain, circumventing the rate-limiting, cytidine triphosphate:phosphocholine cytidylyltransferase in phosphatidylcholine synthesis.	Cytidine Triphosphate	94-115	cut-like homeobox 1	Rattus norvegicus	0-3
15713672-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) is a multi-domain enzyme that regulates phosphatidylcholine synthesis.	Cytidine Triphosphate	0-3	CCT	Homo sapiens	41-44
15829484-0	2005	Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver.	Cytidine Triphosphate	47-50	stearoyl-Coenzyme A desaturase 1	Mus musculus	0-25
15829484-4	2005	The content of phosphatidylcholine (PC) was increased by 40% and the activities of CTP:choline cytidylyltransferase (CCT), the rate-limiting enzyme in de novo PC synthesis, and choline phosphotransferase were increased by 64 and 53%, respectively, in liver of Scd1-/- mice.	Cytidine Triphosphate	83-86	stearoyl-Coenzyme A desaturase 1	Mus musculus	260-264
15982005-1	2005	CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the rate-limiting step in phosphatidylcholine (PC) synthesis, and its activity is regulated by reversible association with membranes, mediated by an amphipathic helical domain M. Here we describe a new feature of the CCTalpha isoform, vesicle tethering.	Cytidine Triphosphate	0-3	phosphate cytidylyltransferase 1A, choline	Homo sapiens	273-281
15788406-0	2005	Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase.	Cytidine Triphosphate	88-91	mitogen-activated protein kinase 1	Homo sapiens	53-56
16055952-2	2005	PC synthesis is controlled by cellular levels of its precursor, cytidine-5"-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine.	Cytidine Triphosphate	134-155	cut-like homeobox 1	Rattus norvegicus	97-100
16011249-7	2005	We found that CTP quadrigeminum had similar secondary structure with hCGbeta, but the speciality of antigen better than that of the latter.	Cytidine Triphosphate	14-17	chorionic gonadotropin subunit beta 3	Homo sapiens	69-76
15752360-9	2005	The data indicate that UPRTase undergoes a transition from a weakly active or inactive T-state, favored by binding of UMP and CTP, to an active R-state, favored by binding of GTP and PRPP.	Cytidine Triphosphate	126-129	DNA-directed RNA polymerase subunit A''	Saccharolobus solfataricus	23-30
15723833-2	2005	The peptide extension (denoted as CTP) is rich in mucin-type O-glycans and confers new hormonal properties on CG relative to the LH.	Cytidine Triphosphate	34-37	LOC100508689	Homo sapiens	50-55
15723833-4	2005	Bioinformatics identified a CTP-like sequence that is encrypted in the LHbeta gene of several mammalian species but not in birds, amphibians, or fish.	Cytidine Triphosphate	28-31	luteinizing hormone subunit beta	Homo sapiens	71-77
15723833-8	2005	This deficiency was further confirmed when the boCTP domain was substituted for the natural CTP in the human CGbeta subunit.	Cytidine Triphosphate	49-52	chorionic gonadotropin subunit beta 3	Homo sapiens	109-115
15723833-12	2005	We propose that in primates and equids, further natural mutations in the progenitor LHbeta gene resulted in the efficient O-glycosylation of the CTP, thus favoring the retention of an elongated reading frame.	Cytidine Triphosphate	145-148	luteinizing hormone subunit beta	Homo sapiens	84-90
15752360-0	2005	Allosteric properties of the GTP activated and CTP inhibited uracil phosphoribosyltransferase from the thermoacidophilic archaeon Sulfolobus solfataricus.	Cytidine Triphosphate	47-50	DNA-directed RNA polymerase subunit A''	Saccharolobus solfataricus	61-93
15590684-6	2005	Tgs1 also methylates the cap analog m(7)GpppA but is unreactive with GTP, GDP, GpppA, m2,2,7GTP, m2,2,7GDP, ATP, CTP, UTP, and ITP.	Cytidine Triphosphate	113-116	RNA methyltransferase	Saccharomyces cerevisiae S288C	0-4
16055952-2	2005	PC synthesis is controlled by cellular levels of its precursor, cytidine-5"-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine.	Cytidine Triphosphate	157-160	cut-like homeobox 1	Rattus norvegicus	97-100
15561837-7	2004	The intracellular half-lives of radiolabeled NHC-triphosphate and of CTP and UTP derived from NHC incubation in Huh-7 cells were calculated to be 3.0 +/- 1.3, 10.4 +/- 3.3, and 13.2 +/- 3.5 h (means +/- standard deviations), respectively.	Cytidine Triphosphate	69-72	high mobility group nucleosomal binding domain 4	Homo sapiens	94-97
15296735-1	2004	CTP synthetase (CTPs) catalyzes the last step in CTP biosynthesis, in which ammonia generated at the glutaminase domain reacts with the ATP-phosphorylated UTP at the synthetase domain to give CTP.	Cytidine Triphosphate	16-19	CTP synthase	Thermus thermophilus HB8	0-14
15296735-1	2004	CTP synthetase (CTPs) catalyzes the last step in CTP biosynthesis, in which ammonia generated at the glutaminase domain reacts with the ATP-phosphorylated UTP at the synthetase domain to give CTP.	Cytidine Triphosphate	0-3	CTP synthase	Thermus thermophilus HB8	16-20
15579793-8	2004	Overall per treatment group, serum E2 and inhibin B concentrations significantly increased only in the two highest FSH-CTP dose groups, reaching peak concentrations at d 3 in the 30-microg group and at d 5 in the 60-microg group.	Cytidine Triphosphate	119-122	cystatin 12, pseudogene	Homo sapiens	35-51
15385935-7	2004	These results suggest that endogenous activity of p38 MAP kinases may be required for committing K562 cells to cell cycle arrest and erythroid differentiation under conditions of CTP depletion.	Cytidine Triphosphate	179-182	mitogen-activated protein kinase 14	Homo sapiens	50-53
15738865-7	2004	RESULTS: Pancytokeratin AE1-AE3 is expressed mainly in CTP (82.5%).	Cytidine Triphosphate	55-58	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	24-27
15738865-7	2004	RESULTS: Pancytokeratin AE1-AE3 is expressed mainly in CTP (82.5%).	Cytidine Triphosphate	55-58	solute carrier family 4 member 3	Homo sapiens	28-31
15738865-9	2004	Vimentin is rather specific of CCC (54.5%) and CTP (85%) whereas it is negative in ONCO and CCHRO.	Cytidine Triphosphate	47-50	vimentin	Homo sapiens	0-8
15738865-10	2004	CD10 is expressed in the majority of CCC (86.5%) and in some of CTP and CCHRO 65 and 39% respectively.	Cytidine Triphosphate	64-67	membrane metalloendopeptidase	Homo sapiens	0-4
15738865-11	2004	CK7 is rather specific of CTP and CCHRO with 79 and 81.5% of positivity rate.	Cytidine Triphosphate	26-29	keratin 7	Homo sapiens	0-3
15198669-5	2004	The activities of CTP : phosphocholine cytidylyltransferase (CCT) and phosphatidylserine synthase were also reduced in brain tissue from Hexb-/- mice, probably because of post-translational modification as no changes were observed in levels of enzyme expression.	Cytidine Triphosphate	18-21	hexosaminidase B	Mus musculus	137-141
15238222-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline.	Cytidine Triphosphate	147-171	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	0-39
15238222-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline.	Cytidine Triphosphate	147-171	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
15238222-1	2004	CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline.	Cytidine Triphosphate	0-3	Phosphocholine cytidylyltransferase 1	Drosophila melanogaster	41-44
15165483-10	2004	The G5M1 MAb reacts only with hCGbeta, hCGbeta-CTP and intact hCG with no detectable cross-reaction with hCGalpha or any of the other glycoprotein hormones.	Cytidine Triphosphate	47-50	chorionic gonadotropin subunit beta 3	Homo sapiens	39-46
15257380-7	2004	Perfusion CT (CTP) can show brain perfusion, allowing one to distinguish between reversible and irreversible damage in an ischemic area.	Cytidine Triphosphate	14-17	solute carrier family 25 member 1	Homo sapiens	10-12
15079868-2	2004	CDP-choline is synthesized by CTP:phosphocholine cytidylyltransferase (CCT), the key rate-limiting enzyme in PtdCho synthesis.	Cytidine Triphosphate	30-33	cut like homeobox 1	Homo sapiens	0-3
15182186-3	2004	We observed that the k(cat) of peptide cleavage decreases with the reduction in the nucleotide binding affinity of Lon in the following order: ATP &gt; CTP &gt; GTP approximately UTP.	Cytidine Triphosphate	152-155	putative ATP-dependent Lon protease	Escherichia coli	115-118
15182186-7	2004	Both adenine-containing nucleotides and CTP protect a 67 kDa fragment of Lon from tryptic digestion.	Cytidine Triphosphate	40-43	putative ATP-dependent Lon protease	Escherichia coli	73-76
15126522-7	2004	The total number of follicles at least 11 mm at stimulation d 8 and at the day of hCG administration tended to increase with dose of FSH-CTP, although a significant dose-response relationship was revealed only for the number of follicles at least 15 mm on the day of hCG (P = 0.03).	Cytidine Triphosphate	137-140	hypertrichosis 2 (generalised, congenital)	Homo sapiens	82-85
15126522-7	2004	The total number of follicles at least 11 mm at stimulation d 8 and at the day of hCG administration tended to increase with dose of FSH-CTP, although a significant dose-response relationship was revealed only for the number of follicles at least 15 mm on the day of hCG (P = 0.03).	Cytidine Triphosphate	137-140	hypertrichosis 2 (generalised, congenital)	Homo sapiens	267-270
14697519-1	2004	CTP: ethanolaminephosphate cytidylyltransferase (Pcyt2) is an important regulatory enzyme in phosphatidylethanolamine and plasmalogen biosynthesis.	Cytidine Triphosphate	0-3	phosphate cytidylyltransferase 2, ethanolamine	Homo sapiens	49-54
14733925-5	2004	We identified a novel short 16kDa isoform in human perilymph and a 18-23kDa isoform in cow perilymph, named Cochlin-tomoprotein (CTP), corresponding to the N-terminus of full-length Cochlin (p63s) and the LCCL domain.	Cytidine Triphosphate	129-132	cochlin	Bos taurus	108-115
14733925-7	2004	The pathogenesis of DFNA9 is not fully clarified as yet, and this novel perilymph-associated CTP isoform might provide mechanistic clues to how mutations in the COCH gene damage the inner ear function.	Cytidine Triphosphate	93-96	cochlin	Bos taurus	161-165
14529283-4	2003	Consistent with the enzyme expressed in mammalian cells, this recombinant NTPDase6 efficiently hydrolyzes GDP, IDP, and UDP (specific activity of approximately 50000 micromol mg(-1) h(-1)), with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP.	Cytidine Triphosphate	231-234	ectonucleoside triphosphate diphosphohydrolase 6	Homo sapiens	74-82
12829450-2	2004	In comparative analysis, we investigated the promoter strength of the CTP:phosphocholine cytidylyltransferase promoter (CCT alpha) with other commonly used promoters, which were all cloned into a similar background vector (PGL3 basic).	Cytidine Triphosphate	70-73	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	120-129
14644392-8	2003	Pre-treatment of J774 foam cells with CTP-cAMP upregulates hormone sensitive lipase (HSL) and further upregulates ATP binding cassette A1 (ABCA1).	Cytidine Triphosphate	38-41	lipase, hormone sensitive	Mus musculus	59-83
14644392-8	2003	Pre-treatment of J774 foam cells with CTP-cAMP upregulates hormone sensitive lipase (HSL) and further upregulates ATP binding cassette A1 (ABCA1).	Cytidine Triphosphate	38-41	lipase, hormone sensitive	Mus musculus	85-88
14644392-8	2003	Pre-treatment of J774 foam cells with CTP-cAMP upregulates hormone sensitive lipase (HSL) and further upregulates ATP binding cassette A1 (ABCA1).	Cytidine Triphosphate	38-41	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	139-144
14529283-4	2003	Consistent with the enzyme expressed in mammalian cells, this recombinant NTPDase6 efficiently hydrolyzes GDP, IDP, and UDP (specific activity of approximately 50000 micromol mg(-1) h(-1)), with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP.	Cytidine Triphosphate	231-234	cut like homeobox 1	Homo sapiens	216-219
12670958-1	2003	The Saccharomyces cerevisiae URA7-encoded CTP synthetase is phosphorylated and stimulated by protein kinase C. We examined the hypothesis that Ser36, Ser330, Ser354, and Ser454, contained in a protein kinase C sequence motif in CTP synthetase, were target sites for the kinase.	Cytidine Triphosphate	42-45	CTP synthase URA7	Saccharomyces cerevisiae S288C	29-33
12910721-11	2003	CTP can reduce P53 protein expression and nerve cell apoptosis, and it can improve motor function.	Cytidine Triphosphate	0-3	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	15-18
12747802-7	2003	Nucleotides inhibited the binding of Bz-[alpha-(32)P]ATP to VCP with the following efficiency: BzATP&gt;ATP&gt;ADP&gt;&gt;adenosine 5"-[beta,gamma-imido]triphosphate&gt;or=adenosine 5"-[beta,gamma-methylene]triphosphate, whereas AMP, GTP and CTP were ineffective.	Cytidine Triphosphate	242-245	valosin containing protein	Homo sapiens	60-63
12885439-5	2003	The rank order of inhibitory potency of endogenous purines on TNF-alpha release was: ATP&gt;ADP&gt;&gt;UTP&gt;UDP&gt;CTP.	Cytidine Triphosphate	117-120	tumor necrosis factor	Rattus norvegicus	62-71
12670958-3	2003	Ser --&gt; Ala (S36A, S330A, S354A, and S454A) mutations in CTP synthetase were constructed by site-directed mutagenesis and expressed normally in a ura7 ura8 double mutant that lacks CTP synthetase activity.	Cytidine Triphosphate	60-63	CTP synthase URA7	Saccharomyces cerevisiae S288C	149-153
12694191-1	2003	UMP-CMP kinase catalyses an important step in the phosphorylation of UTP, CTP and dCTP.	Cytidine Triphosphate	74-77	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-14
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Cytidine Triphosphate	151-175	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	0-45
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Cytidine Triphosphate	151-175	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	47-55
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Cytidine Triphosphate	151-175	cut-like homeobox 1	Rattus norvegicus	185-188
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Cytidine Triphosphate	0-3	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	47-55
12718547-1	2003	CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine.	Cytidine Triphosphate	0-3	cut-like homeobox 1	Rattus norvegicus	185-188
12200438-2	2002	In this study, we have used both nutritional deprivation as well as a conditional temperature sensitive allele of PCT1 (CTP:phosphocholine cytidylyltransferase) coupled with an inactivated phosphatidylethanolamine methylation pathway to determine how cells respond to inactivation of phosphatidylcholine synthesis.	Cytidine Triphosphate	120-123	choline-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	114-118
12213829-2	2002	Ntp and Ctp, synthetic peptides based on the N- and C-terminal sequences of K(IR)6.0, respectively, were used to probe gating of K(IR)6.0/SUR K(ATP) channels.	Cytidine Triphosphate	8-11	ATP binding cassette subfamily C member 8	Homo sapiens	138-141
12620118-9	2003	four wheel drive (fwd) encodes a phosphatidylinositol-4-kinase (PI 4-kinase) and CTP:phosphocholine cytidylyltransferase-l (Cctl) encodes the rate-limiting enzyme in phosphatidylcholine synthesis.	Cytidine Triphosphate	81-84	four wheel drive	Drosophila melanogaster	18-21
12461134-1	2002	We cloned the gene and a cDNA for a second CTP: phosphorylcholine cytidylyltransferase (CCT, EC 2.7.7.15) annotated in chromosome 4 by the Arabidopsis genome project, and designated the gene AtCCT2 to discriminate it from the isogene AtCCT1 in chromosome 2.	Cytidine Triphosphate	43-46	phosphorylcholine cytidylyltransferase2	Arabidopsis thaliana	191-197
12461134-1	2002	We cloned the gene and a cDNA for a second CTP: phosphorylcholine cytidylyltransferase (CCT, EC 2.7.7.15) annotated in chromosome 4 by the Arabidopsis genome project, and designated the gene AtCCT2 to discriminate it from the isogene AtCCT1 in chromosome 2.	Cytidine Triphosphate	43-46	phosphorylcholine cytidylyltransferase	Arabidopsis thaliana	234-240
12213788-0	2002	Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae.	Cytidine Triphosphate	242-245	dolichol kinase	Homo sapiens	139-144
12242028-2	2002	This carboxy terminal peptide (CTP) influences the intracellular behavior of the subunit and is important for maintaining the biological half-life of hCG.	Cytidine Triphosphate	31-34	chorionic gonadotropin subunit beta 5	Homo sapiens	150-153
12100999-0	2002	CTP:phosphocholine cytidylyltransferase and protein kinase C recognize different physical features of membranes: differential responses to an oxidized phosphatidylcholine.	Cytidine Triphosphate	0-3	proline rich transmembrane protein 2	Homo sapiens	44-60
12575328-1	2002	OBJECTIVE: To investigate the effect of vasoactive intestinal peptide(VIP) on the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants and its mechanisms.	Cytidine Triphosphate	93-96	vasoactive intestinal peptide	Rattus norvegicus	70-73
12575328-2	2002	METHODS: The CDP-[M-14 C] choline content reflecting the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants was measured with liquid scintillation.	Cytidine Triphosphate	68-71	cut-like homeobox 1	Rattus norvegicus	13-16
12575328-4	2002	VIP increased the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants in a dose-dependence manner and in a time-dependence fashion; 2.	Cytidine Triphosphate	29-32	vasoactive intestinal peptide	Rattus norvegicus	0-3
12575328-5	2002	The effect of 3 x 10(-7) mol.L-1 VIP on the microsomal CTP: phosphorylcholine cytidylyltransferase activity of cultured lung explants was inhibited by H-7, a protein kinase C(PKC) inhibitor and W-7, a calmodulin antagonist respectively.	Cytidine Triphosphate	55-58	vasoactive intestinal peptide	Rattus norvegicus	33-36
11787058-5	2002	The ATP-induced stimulation of 11beta-HSD2 activity is adenine nucleotide specific in that a similar stimulation was observed with ADP and AMP but not with CTP, GTP, or UTP.	Cytidine Triphosphate	156-159	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	31-42
11931693-7	2002	(3) Hexadecylphosphocholine as well as some ions like Zn2+ and PO3-4 could inhibit the activity of CCTbeta, dCTP was another adaptive substrate of CCTbeta besides CTP.	Cytidine Triphosphate	109-112	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	99-106
11931693-7	2002	(3) Hexadecylphosphocholine as well as some ions like Zn2+ and PO3-4 could inhibit the activity of CCTbeta, dCTP was another adaptive substrate of CCTbeta besides CTP.	Cytidine Triphosphate	109-112	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	147-154
11912132-8	2002	UMP/CMPK used all of the nucleoside triphosphates as phosphate donors, with ATP and dATP being the best donors and CTP being the poorest.	Cytidine Triphosphate	115-118	cytidine/uridine monophosphate kinase 1	Homo sapiens	0-3
11912132-8	2002	UMP/CMPK used all of the nucleoside triphosphates as phosphate donors, with ATP and dATP being the best donors and CTP being the poorest.	Cytidine Triphosphate	115-118	cytidine/uridine monophosphate kinase 1	Homo sapiens	4-8
12403954-7	2002	We sought to assess whether CTP can identify rCBF abnormalities in acute ICH in 5 patients with ICH who underwent CTP within 24 h of symptom onset.	Cytidine Triphosphate	28-31	CCAAT/enhancer binding protein zeta	Rattus norvegicus	45-49
12403954-15	2002	We conclude that CTP identifies a rim of reduced rCBF in ICH.	Cytidine Triphosphate	17-20	CCAAT/enhancer binding protein zeta	Rattus norvegicus	49-53
12199098-8	2002	For Mg2+, ATP-dependent Ca2+ transport in the uterus myocytes mitocondria a high substrate specificity is a characteristic phenomenon in elation to ATP: GTP, CTP and UTP practically fail to provide for Ca accumulation process.	Cytidine Triphosphate	158-161	mucin 7, secreted	Homo sapiens	4-7
11425472-3	2001	UTR1p specifically phosphorylated NAD in the presence of ATP, dATP, or CTP as phosphoryl donors, and was most active at pH 8.0, 30 degrees C. Km values of UTR1p for NAD and ATP were determined to be 0.50 mM and 0.60 mM, respectively.	Cytidine Triphosphate	71-74	NADH/NAD(+) kinase	Saccharomyces cerevisiae S288C	0-5
11404253-0	2001	CTP:phosphocholine cytidylyltransferase inhibition by ceramide via PKC-alpha, p38 MAPK, cPLA2, and 5-lipoxygenase.	Cytidine Triphosphate	0-3	protein kinase C alpha	Homo sapiens	67-76
11404253-0	2001	CTP:phosphocholine cytidylyltransferase inhibition by ceramide via PKC-alpha, p38 MAPK, cPLA2, and 5-lipoxygenase.	Cytidine Triphosphate	0-3	phospholipase A2 group IVA	Homo sapiens	88-93
11404253-0	2001	CTP:phosphocholine cytidylyltransferase inhibition by ceramide via PKC-alpha, p38 MAPK, cPLA2, and 5-lipoxygenase.	Cytidine Triphosphate	0-3	arachidonate 5-lipoxygenase	Homo sapiens	99-113
11404253-2	2001	Am J Physiol Lung Cell Mol Physiol 281: L98-L107, 2001), we demonstrated that tumor necrosis factor (TNF)-alpha inhibited the activity of CTP:phosphocholine cytidylyltransferase (CT), the rate-limiting enzyme in the de novo synthesis of phosphatidylcholine (PC), and that its actions were likely exerted through a metabolite of sphingomyelin.	Cytidine Triphosphate	138-141	tumor necrosis factor	Homo sapiens	78-111
11425472-3	2001	UTR1p specifically phosphorylated NAD in the presence of ATP, dATP, or CTP as phosphoryl donors, and was most active at pH 8.0, 30 degrees C. Km values of UTR1p for NAD and ATP were determined to be 0.50 mM and 0.60 mM, respectively.	Cytidine Triphosphate	71-74	NADH/NAD(+) kinase	Saccharomyces cerevisiae S288C	155-160
12211782-1	2001	In a move to establish measurable, objective criteria for cadaveric liver allocation, the United Network for Organ Sharing OPTN will implement the Model for End Stage Liver Disease (MELD) system in early 2002 as a replacement for the current Child-Turcotte-Pugh (CTP)-based Status 2A, 2B, and 3 categories for patients waiting for a cadaver donor liver transplant.	Cytidine Triphosphate	263-266	optineurin	Homo sapiens	123-127
11337067-4	2001	Arabidopsis FRK1 and FRK2 were capable of employing GTP, CTP, UTP and TTP as phosphate donors, although with a significantly lower efficiency than ATP.	Cytidine Triphosphate	57-60	FLG22-induced receptor-like kinase 1	Arabidopsis thaliana	12-16
11357063-13	2001	We conclude that, with respect to gene copy number, coding sequence and pituitary mRNA size, the gpLH/CGbeta gene locus reflects the CTP-less consensus mammalian LHbeta condition.	Cytidine Triphosphate	133-136	luteinizing hormone subunit beta	Homo sapiens	162-168
11278936-6	2001	The subcellular localization and enzymatic activity of LALP1 indicated that LALP1 is indeed an endo-apyrase with substrate preference for nucleoside triphosphates UTP, GTP, and CTP.	Cytidine Triphosphate	177-180	ectonucleoside triphosphate diphosphohydrolase 7	Homo sapiens	55-60
11278936-6	2001	The subcellular localization and enzymatic activity of LALP1 indicated that LALP1 is indeed an endo-apyrase with substrate preference for nucleoside triphosphates UTP, GTP, and CTP.	Cytidine Triphosphate	177-180	ectonucleoside triphosphate diphosphohydrolase 7	Homo sapiens	76-81
11259526-6	2001	The (m)P2Y(4) receptor was potently, but not selectively, activated by UTP (UTP &gt; or = ATP &gt;ITP &gt; GTP &gt; CTP), and it was not activated by UDP or ADP.	Cytidine Triphosphate	116-119	pyrimidinergic receptor P2Y, G-protein coupled, 4	Mus musculus	7-22
11018759-2	2000	Like the hCG beta, the equine eLH and eCG beta subunits, also possess a C-terminal extension (CTP).	Cytidine Triphosphate	94-97	chorionic gonadotropin subunit beta 3	Homo sapiens	9-17
11036089-4	2000	In situ hybridization was carried out using a [(35)S]-CTP-labeled CSD RNA probe.	Cytidine Triphosphate	54-57	cysteine sulfinic acid decarboxylase	Rattus norvegicus	66-69
10738128-4	2000	The CTP synthetase activity in ANLL cells (5.1+/-2.3 nmol CTP/mg/h) was significantly higher compared with granulocytes of healthy controls (0.6+/-0.4 nmol CTP/mg/h, P=0.0002), but was not different from the CTP synthetase activity in non-malignant CD34+ bone marrow cells (5.	Cytidine Triphosphate	4-7	CD34 molecule	Homo sapiens	249-253
10973058-1	2000	Phosphatidylcholine (PC) synthesis in animal cells is generally controlled by cytidine 5"-triphosphate (CTP):phosphocholine cytidylyltransferase (CCT).	Cytidine Triphosphate	78-102	CCT	Homo sapiens	146-149
10858452-9	2000	Comparison of the enzymatic properties of the splice variants revealed a broader substrate specificity for hLALP70v with CTP, UDP, CDP, GTP, and GDP as preferred substrates, while hLALP70 utilized UTP and TTP preferentially.	Cytidine Triphosphate	121-124	ectonucleoside triphosphate diphosphohydrolase 4	Homo sapiens	107-114
10873749-10	2000	We suggest that these three amino acid changes in nsP4 alter the geometry of the NTP binding pocket so as to increase the affinity of the enzyme for CTP and UTP.	Cytidine Triphosphate	149-152	serine protease 57	Homo sapiens	50-54
10614624-5	2000	Herein, we report the construction of a new single chain hCG analog (YhCG3) in which the C-terminus of the alpha-subunit is fused to the N-terminus of hCGbeta via a CTP (N-alpha-CTP-beta-C).	Cytidine Triphosphate	165-168	chorionic gonadotropin subunit beta 3	Homo sapiens	151-158
10666123-15	2000	Fourth, HGF inhibits the rate-limiting enzyme in de novo phosphatidylcholine synthesis, CTP:choline-phosphate cytidylyltransferase (EC 2.7.7.15).	Cytidine Triphosphate	88-91	hepatocyte growth factor	Homo sapiens	8-11
10388478-8	1999	Western blot analysis of the same samples using cTnI NTP- and CTP-specific antibodies demonstrated preferential degradation of the CTP of cTnI.	Cytidine Triphosphate	62-65	troponin I3, cardiac type	Homo sapiens	138-142
11270954-7	2000	CONCLUSION: High CTP activity in cardiovascular patients may be explained by chymase and cathepsin G release into blood flow indicating activation of alternative to ACE pathway of angiotensin II production or the presence of the inflammatory process.	Cytidine Triphosphate	17-20	cathepsin G	Homo sapiens	89-100
11270954-7	2000	CONCLUSION: High CTP activity in cardiovascular patients may be explained by chymase and cathepsin G release into blood flow indicating activation of alternative to ACE pathway of angiotensin II production or the presence of the inflammatory process.	Cytidine Triphosphate	17-20	angiotensin I converting enzyme	Homo sapiens	165-168
11270954-7	2000	CONCLUSION: High CTP activity in cardiovascular patients may be explained by chymase and cathepsin G release into blood flow indicating activation of alternative to ACE pathway of angiotensin II production or the presence of the inflammatory process.	Cytidine Triphosphate	17-20	angiotensinogen	Homo sapiens	180-194
10409709-4	1999	The activity was equally high toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate, but there was no activity toward GMP, indicating that the Ynd1 protein belongs to the apyrase family.	Cytidine Triphosphate	105-108	apyrase	Saccharomyces cerevisiae S288C	195-199
10388478-8	1999	Western blot analysis of the same samples using cTnI NTP- and CTP-specific antibodies demonstrated preferential degradation of the CTP of cTnI.	Cytidine Triphosphate	131-134	troponin I3, cardiac type	Homo sapiens	48-52
12687122-2	1999	I have detected hitherto unreported identity of HCG-beta sequence with tetrapeptides of PECAM-1, galactosyl transferase-associated protein kinase, insulin receptor-related receptor and carboxypeptidase E. A predicted potential epitope of C-terminal peptide (CTP) of HCG-beta was identical to a tetrapeptide stretch of MCSF-1.	Cytidine Triphosphate	258-261	chorionic gonadotropin subunit beta 3	Homo sapiens	48-56
10388478-8	1999	Western blot analysis of the same samples using cTnI NTP- and CTP-specific antibodies demonstrated preferential degradation of the CTP of cTnI.	Cytidine Triphosphate	131-134	troponin I3, cardiac type	Homo sapiens	138-142
12687122-2	1999	I have detected hitherto unreported identity of HCG-beta sequence with tetrapeptides of PECAM-1, galactosyl transferase-associated protein kinase, insulin receptor-related receptor and carboxypeptidase E. A predicted potential epitope of C-terminal peptide (CTP) of HCG-beta was identical to a tetrapeptide stretch of MCSF-1.	Cytidine Triphosphate	258-261	platelet and endothelial cell adhesion molecule 1	Homo sapiens	88-95
9854020-8	1999	PEMT activity decreased, the levels of PEMT2 mRNA decreased and there was an increase in the activity of CTP:phosphocholine cytidylyltransferase, a key regulatory enzyme in the CDP-choline pathway of phosphatidylcholine biosynthesis.	Cytidine Triphosphate	105-108	phosphatidylethanolamine N-methyltransferase	Homo sapiens	0-4
10207180-2	1999	CMP-neuNAc synthetase catalyzes the formation of this substrate, CMP-neuNAc, from CTP and neuNAc.	Cytidine Triphosphate	82-85	cytidine monophosphate N-acetylneuraminic acid synthetase	Bos taurus	0-21
10224101-1	1999	To probe the mechanism of lipid activation of CTP:phosphocholine cytidylyltransferase (CCTalpha), we have characterized a catalytic fragment of the enzyme that lacks the membrane-binding segment.	Cytidine Triphosphate	46-49	choline-phosphate cytidylyltransferase A	Cricetulus griseus	87-95
11939039-5	1998	It indicates that CTP and COV can cause the p21 protein level increase in the occupational population.	Cytidine Triphosphate	18-21	H3 histone pseudogene 16	Homo sapiens	44-47
10548880-4	1999	The CG beta subunit contains a carboxy-terminal extension (CTP) with four serine O-linked oligosaccharides, which is important for the long half-life of hCG.	Cytidine Triphosphate	59-62	chorionic gonadotropin subunit beta 3	Homo sapiens	4-11
10548880-4	1999	The CG beta subunit contains a carboxy-terminal extension (CTP) with four serine O-linked oligosaccharides, which is important for the long half-life of hCG.	Cytidine Triphosphate	59-62	chorionic gonadotropin subunit beta 5	Homo sapiens	153-156
10548880-6	1999	Fusing CTP to the FSH beta coding sequence increased the in vivo potency of the resulting FSH dimer over three-fold.	Cytidine Triphosphate	7-10	follicle stimulating hormone subunit beta	Homo sapiens	18-26
9799561-0	1998	Uridine kinase: altered enzyme with decreased affinities for uridine and CTP.	Cytidine Triphosphate	73-76	uridine-cytidine kinase 2	Homo sapiens	0-14
9799561-7	1998	Mouse uridine kinase is normally an active tetramer that will dissociate to inactive monomers in response to CTP.	Cytidine Triphosphate	109-112	uridine-cytidine kinase 2	Homo sapiens	6-20
9748300-8	1998	Moreover, geranylgeraniol and farnesol induced a rapid inhibition of phosphatidylcholine biosynthesis at the last step of the CDP-choline pathway controlled by choline phosphotransferase and not at the level of CTP:phosphocholine cytidylyltransferase, the key enzyme of the pathway.	Cytidine Triphosphate	211-214	cut like homeobox 1	Homo sapiens	126-129
9611231-4	1998	Hydrolysis of dATP or ATP, and to a lesser extent hydrolysis of dCTP or CTP, supports WRN-catalyzed strand-displacement.	Cytidine Triphosphate	65-68	WRN RecQ like helicase	Homo sapiens	86-89
9827660-7	1998	As a next step, we developed a technique for TRH mRNA in situ hybridization using a [35S] CTP-labeled TRH cRNA antisense probe in formalin-fixed paraffin-embedded sections.	Cytidine Triphosphate	90-93	thyrotropin releasing hormone	Homo sapiens	45-48
9731198-3	1998	In the ED2 and Y8 cells that did not express p53 protein, the pools of UTP, CTP, ATP, and GTP were markedly decreased.	Cytidine Triphosphate	76-79	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	Mus musculus	7-10
9668079-2	1998	Amino acid residue Glu161 in the URA7-encoded and URA8-encoded CTP synthetases was identified as being involved in the regulation of these enzymes by CTP product inhibition.	Cytidine Triphosphate	63-66	CTP synthase URA7	Saccharomyces cerevisiae S288C	33-37
9668079-2	1998	Amino acid residue Glu161 in the URA7-encoded and URA8-encoded CTP synthetases was identified as being involved in the regulation of these enzymes by CTP product inhibition.	Cytidine Triphosphate	63-66	CTP synthase URA8	Saccharomyces cerevisiae S288C	50-54
9668079-4	1998	The E161K mutant URA7-encoded and URA8-encoded CTP synthetases were less sensitive to CTP product inhibition with inhibitor constants for CTP of 8.4- and 5-fold greater, respectively, than those of their wild-type counterparts.	Cytidine Triphosphate	47-50	CTP synthase URA7	Saccharomyces cerevisiae S288C	17-21
9668079-4	1998	The E161K mutant URA7-encoded and URA8-encoded CTP synthetases were less sensitive to CTP product inhibition with inhibitor constants for CTP of 8.4- and 5-fold greater, respectively, than those of their wild-type counterparts.	Cytidine Triphosphate	47-50	CTP synthase URA8	Saccharomyces cerevisiae S288C	34-38
9668079-4	1998	The E161K mutant URA7-encoded and URA8-encoded CTP synthetases were less sensitive to CTP product inhibition with inhibitor constants for CTP of 8.4- and 5-fold greater, respectively, than those of their wild-type counterparts.	Cytidine Triphosphate	86-89	CTP synthase URA7	Saccharomyces cerevisiae S288C	17-21
9668079-4	1998	The E161K mutant URA7-encoded and URA8-encoded CTP synthetases were less sensitive to CTP product inhibition with inhibitor constants for CTP of 8.4- and 5-fold greater, respectively, than those of their wild-type counterparts.	Cytidine Triphosphate	86-89	CTP synthase URA8	Saccharomyces cerevisiae S288C	34-38
9827660-7	1998	As a next step, we developed a technique for TRH mRNA in situ hybridization using a [35S] CTP-labeled TRH cRNA antisense probe in formalin-fixed paraffin-embedded sections.	Cytidine Triphosphate	90-93	thyrotropin releasing hormone	Homo sapiens	102-105
9266842-3	1997	On the other hand, with ATP analogues of CTP and ITP, sliding movements of cleaved actin and particularly intact actin were inhibited by native tropomyosin, indicating that native tropomyosin augmented specificity of the myosin substrate of NTP.	Cytidine Triphosphate	41-44	myosin heavy chain 14	Homo sapiens	149-155
9345289-1	1997	CDP-diacylglycerol synthase, also known as CTP: phosphatidic acid cytidylyltransferase (EC 2.7.7.41), is thought to be the rate-limiting enzyme in the synthesis of the inositol phospholipids, phosphatidylglycerol and cardiolipin.	Cytidine Triphosphate	43-46	TAM41 mitochondrial translocator assembly and maintenance homolog	Homo sapiens	0-27
9547267-2	1998	The 5"-triphosphate of this analogue is readily incorporated by T3, T7 and SP6 RNA polymerases into RNA transcripts, being best incorporated in place of UTP, but also in place of CTP.	Cytidine Triphosphate	179-182	Sp6 transcription factor	Homo sapiens	75-78
9484671-10	1998	Antibodies raised in women to the beta-subunit of hCG had equilibrium constants higher by one to two orders of magnitude than those of the anti-CTP antibodies.	Cytidine Triphosphate	144-147	chorionic gonadotropin subunit beta 5	Homo sapiens	50-53
9257926-13	1997	The potency order for agonists of P2X2 receptors was: ATP&gt; 2-MeS-ATP ATPgammaS&gt; ATPalphaS&gt; &gt;CTP &gt;BzATP, while other nucleotides were inactive.	Cytidine Triphosphate	104-107	purinergic receptor P2X, ligand gated ion channel, 2 L homeolog	Xenopus laevis	34-38
9201693-6	1997	In McA-11 and McA-17 cells, overexpressing calreticulin, glucocorticoid-sensitive expression of the TAT gene was significantly inhibited, however, the CTP-cAMP-dependent expression of the TAT gene was not affected.	Cytidine Triphosphate	151-154	calreticulin	Rattus norvegicus	43-55
9201693-6	1997	In McA-11 and McA-17 cells, overexpressing calreticulin, glucocorticoid-sensitive expression of the TAT gene was significantly inhibited, however, the CTP-cAMP-dependent expression of the TAT gene was not affected.	Cytidine Triphosphate	151-154	tyrosine aminotransferase	Rattus norvegicus	100-103
9115637-2	1997	CDP-diacylglycerol synthase (CDS) or CTP:phosphatidate cytidylyltransferase (EC 2.7.7.41) catalyzes the conversion of PA to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	Cytidine Triphosphate	37-40	TAM41 mitochondrial translocator assembly and maintenance homolog	Homo sapiens	0-27
9139711-4	1997	Recombinant XlP2Y responds equally to all five naturally occurring nucleoside triphosphates (ATP, UTP, CTP, GTP, and ITP), which elicit a biphasic Ca2+-dependent Cl- current (ICl,Ca) where the second phase persists for up to 60 min.	Cytidine Triphosphate	103-106	pyrimidinergic receptor P2Y, G-protein coupled, 4 L homeolog	Xenopus laevis	12-17
9139692-5	1997	T7 primase extends the dinucleotide AC and trinucleotide ACC to ACCC in the presence of CTP and an appropriate template, whereas other dinucleotides are extended less efficiently; the deoxyribodinucleotide dAC is not extended.	Cytidine Triphosphate	88-91	dachshund	Drosophila melanogaster	36-38
9139692-5	1997	T7 primase extends the dinucleotide AC and trinucleotide ACC to ACCC in the presence of CTP and an appropriate template, whereas other dinucleotides are extended less efficiently; the deoxyribodinucleotide dAC is not extended.	Cytidine Triphosphate	88-91	dachshund	Drosophila melanogaster	206-209
9115637-2	1997	CDP-diacylglycerol synthase (CDS) or CTP:phosphatidate cytidylyltransferase (EC 2.7.7.41) catalyzes the conversion of PA to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.	Cytidine Triphosphate	37-40	TAM41 mitochondrial translocator assembly and maintenance homolog	Homo sapiens	29-32
8961276-1	1996	One of the major structural differences between the LH beta and CG beta subunits is the carboxy-terminal region: beyond amino acid 114, LH beta has a hydrophobic heptapeptide stretch, while CG beta contains a 31-amino acid hydrophilic carboxy-terminal peptide (CTP) that is O-glycosylated.	Cytidine Triphosphate	261-264	luteinizing hormone subunit beta	Homo sapiens	52-59
9027345-7	1996	(The CTP sequence is the last 28 amino acids of the CG beta sequence and contains four serine-linked oligosaccharides).	Cytidine Triphosphate	5-8	chorionic gonadotropin subunit beta 3	Homo sapiens	52-59
9016352-8	1997	The human P2X4 receptor displays a very similar agonist potency profile to that of rat P2X4 (ATP &gt; &gt; 2-methylthio-ATP &gt; or = CTP &gt; alpha, beta-methylene-ATP &gt; dATP) but has a notably higher sensitivity for the antagonists suramin, pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, and bromphenol blue.	Cytidine Triphosphate	134-137	purinergic receptor P2X 4	Rattus norvegicus	10-14
9016352-8	1997	The human P2X4 receptor displays a very similar agonist potency profile to that of rat P2X4 (ATP &gt; &gt; 2-methylthio-ATP &gt; or = CTP &gt; alpha, beta-methylene-ATP &gt; dATP) but has a notably higher sensitivity for the antagonists suramin, pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, and bromphenol blue.	Cytidine Triphosphate	134-137	purinergic receptor P2X 4	Rattus norvegicus	87-91
8961276-7	1996	Fusion of this heptapeptide to CG beta 114, i.e. CG beta lacking the CTP, decreased the amount of secreted subunit 2-fold compared with wild type human CG beta.	Cytidine Triphosphate	69-72	chorionic gonadotropin subunit beta 3	Homo sapiens	31-38
8961276-7	1996	Fusion of this heptapeptide to CG beta 114, i.e. CG beta lacking the CTP, decreased the amount of secreted subunit 2-fold compared with wild type human CG beta.	Cytidine Triphosphate	69-72	chorionic gonadotropin subunit beta 3	Homo sapiens	49-56
8961276-7	1996	Fusion of this heptapeptide to CG beta 114, i.e. CG beta lacking the CTP, decreased the amount of secreted subunit 2-fold compared with wild type human CG beta.	Cytidine Triphosphate	69-72	chorionic gonadotropin subunit beta 3	Homo sapiens	49-56
8982874-0	1996	Isolation and characterization of ECT1 gene encoding CTP: phosphoethanolamine cytidylyltransferase of Saccharomyces cerevisiae.	Cytidine Triphosphate	53-56	ethanolamine-phosphate cytidylyltransferase	Saccharomyces cerevisiae S288C	34-38
8725976-12	1996	However, at 24 months the patients in CTP were more likely to achieve LDL goal levels (65% vs 44%, p &lt; .005), and also achieved greater reductions in LDL-C 27% +/- 2% vs 14% +/- 2% at 24 months, p &lt; .001).	Cytidine Triphosphate	38-41	component of oligomeric golgi complex 2	Homo sapiens	153-158
8626655-1	1996	In this work we examined the regulation of CTP synthetase activity by S. cerevisiae protein kinase C (Pkc1p) phosphorylation.	Cytidine Triphosphate	43-46	protein kinase C	Saccharomyces cerevisiae S288C	102-107
8725976-13	1996	Program costs per unit (mmol/L) reduction in the LDL-C, a measure of cost-effectiveness, was significantly lower for CTP ($758 +/- $58 vs $1,058 +/- $70, p = .002).	Cytidine Triphosphate	117-120	component of oligomeric golgi complex 2	Homo sapiens	49-54
8568673-10	1995	Of other nucleotides tested, only CTP consistently activated BKCa channel activity.	Cytidine Triphosphate	34-37	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	61-65
7487072-8	1995	ATP is the preferred substrate for the NTPase; GTP is also utilized; however, UTP is a very poor substrate and CTP is not utilized.	Cytidine Triphosphate	111-114	inosine triphosphatase	Homo sapiens	39-45
8651941-10	1996	At 1 and 10 muM of deoxycytidine the effects of CTP on dCK activity in A2780, C26-10 and WiDr cells were less pronounced.	Cytidine Triphosphate	48-51	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	55-58
8617732-1	1996	CCA1 codes for mitochondrial, cytosolic, and nuclear ATP(CTP):tRNA nucleotidyltransferase.	Cytidine Triphosphate	57-60	tRNA adenylyltransferase	Saccharomyces cerevisiae S288C	0-4
7559626-1	1995	The URA7- and URA8-encoded CTP synthetases (EC 6.3.4.2, UTP:ammonia ligase (ADP-forming) are functionally overlapping enzymes responsible for the biosynthesis of CTP in the yeast Saccharomyces cerevisiae.	Cytidine Triphosphate	27-30	CTP synthase URA7	Saccharomyces cerevisiae S288C	4-8
7559626-1	1995	The URA7- and URA8-encoded CTP synthetases (EC 6.3.4.2, UTP:ammonia ligase (ADP-forming) are functionally overlapping enzymes responsible for the biosynthesis of CTP in the yeast Saccharomyces cerevisiae.	Cytidine Triphosphate	27-30	CTP synthase URA8	Saccharomyces cerevisiae S288C	14-18
7559626-1	1995	The URA7- and URA8-encoded CTP synthetases (EC 6.3.4.2, UTP:ammonia ligase (ADP-forming) are functionally overlapping enzymes responsible for the biosynthesis of CTP in the yeast Saccharomyces cerevisiae.	Cytidine Triphosphate	162-165	CTP synthase URA7	Saccharomyces cerevisiae S288C	4-8
7559626-1	1995	The URA7- and URA8-encoded CTP synthetases (EC 6.3.4.2, UTP:ammonia ligase (ADP-forming) are functionally overlapping enzymes responsible for the biosynthesis of CTP in the yeast Saccharomyces cerevisiae.	Cytidine Triphosphate	162-165	CTP synthase URA8	Saccharomyces cerevisiae S288C	14-18
7559626-9	1995	CTP potently inhibited (IC50 = 85 microM) URA8-encoded CTP synthetase activity and, in addition, caused the dependence of activity toward UTP to become cooperative.	Cytidine Triphosphate	0-3	CTP synthase URA8	Saccharomyces cerevisiae S288C	42-46
7559626-10	1995	The URA8-encoded CTP synthetase and the previously purified URA7-encoded CTP synthetase differed significantly with respect to several biochemical properties including turnover number, pH optimum, substrate dependences, and sensitivity to inhibition by CTP.	Cytidine Triphosphate	17-20	CTP synthase URA8	Saccharomyces cerevisiae S288C	4-8
7481839-5	1995	In contrast, a CHO mutant deficient in deoxycytidine kinase, and thus unable to accumulate dFdCTP, maintained its CTP pools under identical conditions, suggesting that the CTP pool depletion was dependent on dFdC phosphorylation.	Cytidine Triphosphate	114-117	deoxycytidine kinase	Cricetulus griseus	39-59
7530051-7	1995	The splicing activity of CYT-18 was unaffected by aminoacylation substrates at concentrations used in aminoacylation reactions, whereas the TyrRS activity was inhibited by physiological concentrations of the splicing cofactor GTP, as well as CTP or UTP, or by low concentrations of a group I intron RNA.	Cytidine Triphosphate	242-245	tyrosyl-tRNA synthetase 2	Homo sapiens	140-145
7797479-2	1995	Using pure CTP by synthetase as a substrate, protein kinase C activity was dose- and time-dependent and required calcium, diacylglycerol, and phosphatidylserine for full activation.	Cytidine Triphosphate	11-14	protein kinase C	Saccharomyces cerevisiae S288C	45-61
7797479-4	1995	Protein kinase C phosphorylated CTP synthetase on serine and threonine residues in vitro whereas the enzyme was primarily phosphorylated on serine residues in vivo.	Cytidine Triphosphate	32-35	protein kinase C	Saccharomyces cerevisiae S288C	0-16
7539107-1	1995	The hCG beta-subunit contains a carboxy-terminal extension bearing four serine-linked oligosaccharides [carboxy-terminal peptide (CTP)], which is important for maintaining its longer half-life compared with the other glycoprotein hormones.	Cytidine Triphosphate	130-133	chorionic gonadotropin subunit beta 3	Homo sapiens	4-12
7798951-3	1995	The maximal rise in cyclic GMP level achieved was highest for ATP and decreased in the following order: ATP = adenosine 5"(gamma-thio)triphosphate &gt; UTP = 2-methylthio-ATP &gt; ADP much greater than CTP, AMP, alpha,beta-methylene-ATP, 2"- and 3"-O-(4-benzoylbenzoyl)ATP.	Cytidine Triphosphate	202-205	5'-nucleotidase, cytosolic II	Mus musculus	27-30
7767883-4	1994	We show that Ca2+ can initiate contractions supported by cytidine triphosphate (CTP) and that these contractions are inhibited by calmodulin antagonists, suggesting a Ca(2+)-calmodulin dependence of force distinct from that for MLC phosphorylation.	Cytidine Triphosphate	57-78	calmodulin 1	Homo sapiens	174-184
7633194-3	1994	A carboxyl terminal peptide beta-hCG (CTP-beta-hCG) assay with a sensitivity of 0.2 mIU/mL was used to measure serum levels.	Cytidine Triphosphate	38-41	chorionic gonadotropin subunit beta 5	Homo sapiens	47-50
7767883-4	1994	We show that Ca2+ can initiate contractions supported by cytidine triphosphate (CTP) and that these contractions are inhibited by calmodulin antagonists, suggesting a Ca(2+)-calmodulin dependence of force distinct from that for MLC phosphorylation.	Cytidine Triphosphate	80-83	calmodulin 1	Homo sapiens	174-184
7748951-3	1994	The product of the MOD5 gene is isopentenyl pyrophosphate: tRNA isopentenyl transferase and the product of the CCA1 gene is ATP (CTP): tRNA nucleotidyltransferase.	Cytidine Triphosphate	129-132	tRNA dimethylallyltransferase	Saccharomyces cerevisiae S288C	19-23
7926053-1	1994	The effect of insulin and epidermal growth factor on the phosphorylation of CTP:phosphocholine cytidylyltransferase (EC 2.7.7.15) was investigated in HeLa cells.	Cytidine Triphosphate	76-79	insulin	Homo sapiens	14-21
7926053-1	1994	The effect of insulin and epidermal growth factor on the phosphorylation of CTP:phosphocholine cytidylyltransferase (EC 2.7.7.15) was investigated in HeLa cells.	Cytidine Triphosphate	76-79	epidermal growth factor	Homo sapiens	26-49
8044894-11	1994	After a 3-h treatment, CTP: cholinephosphate cytidylyltransferase (CYT) in both the cytosolic and microsomal fractions was inhibited by approximately 20 per cent, while choline kinase (CK) and choline phosphotransferase (CPT) remain relatively unchanged.	Cytidine Triphosphate	23-26	choline phosphotransferase 1	Homo sapiens	193-219
8044894-11	1994	After a 3-h treatment, CTP: cholinephosphate cytidylyltransferase (CYT) in both the cytosolic and microsomal fractions was inhibited by approximately 20 per cent, while choline kinase (CK) and choline phosphotransferase (CPT) remain relatively unchanged.	Cytidine Triphosphate	23-26	choline phosphotransferase 1	Homo sapiens	221-224
7969099-6	1994	Of the radioinert nucleotides (ATP, GTP, UTP or CTP) tested, only ATP successfully competed with [gamma-32P]ATP demonstrating a nucleotide specific requirement for the phosphorylation of GR.	Cytidine Triphosphate	48-51	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	187-189
7509735-7	1994	Competition experiments using combinations of monoclonal antibodies and rabbit anti-beta CTP antiserum demonstrated that two epitopes exist within the beta-(115-145) region of hCG, one of which depends on the presence of carbohydrate.	Cytidine Triphosphate	89-92	chorionic gonadotropin subunit beta 5	Homo sapiens	176-179
7866292-13	1994	It is proposed that the effects of dietary lipid manipulation upon CTP I activity and sensitivity to inhibition by malonyl CoA are due to alterations in the fatty acid composition of the phospholipids in the mitochondrial membrane where CPT I resides.	Cytidine Triphosphate	67-70	carnitine palmitoyltransferase 1B	Rattus norvegicus	237-242
8121398-3	1994	The present paper describes the selection of synthetic lethal mutants in the CTP biosynthetic pathway that led us to clone a second gene, named URA8, which also encodes a CTP synthetase.	Cytidine Triphosphate	77-80	CTP synthase URA8	Saccharomyces cerevisiae S288C	144-148
8121398-6	1994	Based on the codon bias values for the two genes and the intracellular concentrations of CTP in strains deleted for one of the two genes, relative to the wild-type level, URA7 appears to be the major gene for CTP biosynthesis.	Cytidine Triphosphate	89-92	CTP synthase URA7	Saccharomyces cerevisiae S288C	171-175
8121398-6	1994	Based on the codon bias values for the two genes and the intracellular concentrations of CTP in strains deleted for one of the two genes, relative to the wild-type level, URA7 appears to be the major gene for CTP biosynthesis.	Cytidine Triphosphate	209-212	CTP synthase URA7	Saccharomyces cerevisiae S288C	171-175
7748951-3	1994	The product of the MOD5 gene is isopentenyl pyrophosphate: tRNA isopentenyl transferase and the product of the CCA1 gene is ATP (CTP): tRNA nucleotidyltransferase.	Cytidine Triphosphate	129-132	tRNA adenylyltransferase	Saccharomyces cerevisiae S288C	111-115
8231655-4	1993	PC synthesis was increased, as evidenced by increased incorporation of [3H]choline into PC and an increased activity of cytidinetriphosphate (CTP): phosphocholine cytidylyltransferase.	Cytidine Triphosphate	120-140	procollagen C-endopeptidase enhancer	Rattus norvegicus	0-2
8181450-0	1994	Epidermal growth factor is a positive in vivo regulator of CTP:cholinephosphate cytidylyltransferase.	Cytidine Triphosphate	59-62	epidermal growth factor like 1	Rattus norvegicus	0-23
8231655-4	1993	PC synthesis was increased, as evidenced by increased incorporation of [3H]choline into PC and an increased activity of cytidinetriphosphate (CTP): phosphocholine cytidylyltransferase.	Cytidine Triphosphate	142-145	procollagen C-endopeptidase enhancer	Rattus norvegicus	0-2
8392813-3	1993	The developmental profile of the enzymes of the CDP-choline pathway suggests that CTP:choline-phosphate cytidylyltransferase catalyses a rate regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells.	Cytidine Triphosphate	82-85	cut-like homeobox 1	Rattus norvegicus	48-51
8380408-3	1993	Helicase activity is coupled to the hydrolysis of ATP or dATP and to a lesser extent to CTP, dCTP, or UTP.	Cytidine Triphosphate	88-91	helicase for meiosis 1	Homo sapiens	0-8
8503153-3	1993	Genomic APRT genes were amplified and labeled simultaneously with [alpha-32P]dCTP (cytidine triphosphate) by PCR.	Cytidine Triphosphate	83-104	adenine phosphoribosyltransferase	Homo sapiens	8-12
1659321-6	1991	Substrate specificity studies show that the relative activity of nucleoside diphosphates (NDP) as phosphate acceptors is in the order of dTDP greater than CDP greater than UDP greater than dUDP greater than GDP greater than or equal to dGDP greater than dCDP greater than dADP greater than ADP; and the relative activity of triphosphate donors is in the order of UTP greater than dTTP greater than CTP greater than dCTP greater than dATP greater than ATP greater than or equal to dGTP greater than GTP.	Cytidine Triphosphate	398-401	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	137-141
1460050-1	1992	The anaerobic ribonucleoside triphosphate reductase from Escherichia coli reduces CTP to dCTP in the presence of a second protein, named dA1, and a Chelex-treated boiled extract of the bacteria, named RT.	Cytidine Triphosphate	82-85	anon-A1	Drosophila melanogaster	137-140
1447319-10	1992	Analysis of the CDP-choline pathway of PC synthesis indicated that the regulatory enzyme, CTP:phosphorylcholine cytidylyltransferase, was stimulated about twofold by PDBu in cells having normal membrane, but not in PE-deficient cells.	Cytidine Triphosphate	90-93	cut-like homeobox 1	Rattus norvegicus	16-19
1608935-1	1992	CTP (ATP) binding to the T or R state causes reorientation of several key residues and results in a decrease (increase) in the size of the nucleotide binding site and a related decrease (increase) in the extension of the outer parts of the dimer of the regulatory chains, R1 and R6.	Cytidine Triphosphate	0-3	CD1b molecule	Homo sapiens	272-281
1379674-7	1992	There is, however, little amino acid homology shown between the CTP of human or equine CG beta subunit.	Cytidine Triphosphate	64-67	chorionic gonadotropin subunit beta 3	Homo sapiens	87-94
1577759-8	1992	The enzyme also converts N-glycolylneuraminic acid to its corresponding CMP-sialic acid (Km, 2.6 mM), whereas CMP-NeuAc, high CTP concentrations, and other nucleotides (CDP, CMP, ATP, UTP, GTP, and TTP) inhibited the enzyme to different extents.	Cytidine Triphosphate	126-129	alpha tocopherol transfer protein	Rattus norvegicus	198-201
1433372-6	1992	By calculating the percent of TK activity in the presence of adenosine triphosphate (ATP) or cytidine triphosphate (CTP), we estimated the relative contributions of TK isozymes TK1 and TK2 to total TK activity.	Cytidine Triphosphate	93-114	thymidine kinase 2	Homo sapiens	30-32
1433372-6	1992	By calculating the percent of TK activity in the presence of adenosine triphosphate (ATP) or cytidine triphosphate (CTP), we estimated the relative contributions of TK isozymes TK1 and TK2 to total TK activity.	Cytidine Triphosphate	116-119	thymidine kinase 2	Homo sapiens	30-32
1433372-8	1992	Calculations of the percent of TK activity in the presence of ATP or CTP showed that this elevation was due to increased TK1 isozyme levels.	Cytidine Triphosphate	69-72	thymidine kinase 2	Homo sapiens	31-33
1433372-8	1992	Calculations of the percent of TK activity in the presence of ATP or CTP showed that this elevation was due to increased TK1 isozyme levels.	Cytidine Triphosphate	69-72	thymidine kinase 1	Homo sapiens	121-124
1433372-10	1992	ER- patients with recurrence had significantly (P &lt; .001) elevated total tumor TK levels compared with levels in those who did not have recurrence, and calculation of percent of TK activity with ATP or CTP indicated elevated TK1 levels.	Cytidine Triphosphate	205-208	thymidine kinase 2	Homo sapiens	181-183
1433372-10	1992	ER- patients with recurrence had significantly (P &lt; .001) elevated total tumor TK levels compared with levels in those who did not have recurrence, and calculation of percent of TK activity with ATP or CTP indicated elevated TK1 levels.	Cytidine Triphosphate	205-208	thymidine kinase 1	Homo sapiens	228-231
1379674-1	1992	Equine (e) CG and LH beta-subunits have identical amino acid sequences, including an extended carboxyl-terminal peptide (CTP).	Cytidine Triphosphate	121-124	lutropin/choriogonadotropin subunit beta	Equus caballus	18-25
1379674-6	1992	The eLH/CG beta gene spans less than 1.2 kilobase-pairs and has three exons that translate a CTP-containing polypeptide identical in sequence to that previously reported for the mature equine protein.	Cytidine Triphosphate	93-96	chorionic gonadotropin subunit beta 3	Homo sapiens	8-15
1548980-2	1992	This enzyme specifically cleaves big endothelin-1 (big ET-1) at the proper site, between Trp21 and Val22, with maximum activity at pH 7.5 and with a Km of roughly 3 microM, to produce endothelin-1 (ET-1) and C-terminal peptide (CTP).	Cytidine Triphosphate	228-231	endothelin 1	Bos taurus	37-49
1548980-2	1992	This enzyme specifically cleaves big endothelin-1 (big ET-1) at the proper site, between Trp21 and Val22, with maximum activity at pH 7.5 and with a Km of roughly 3 microM, to produce endothelin-1 (ET-1) and C-terminal peptide (CTP).	Cytidine Triphosphate	228-231	endothelin 1	Bos taurus	55-59
1548980-2	1992	This enzyme specifically cleaves big endothelin-1 (big ET-1) at the proper site, between Trp21 and Val22, with maximum activity at pH 7.5 and with a Km of roughly 3 microM, to produce endothelin-1 (ET-1) and C-terminal peptide (CTP).	Cytidine Triphosphate	228-231	endothelin 1	Bos taurus	184-196
1548980-2	1992	This enzyme specifically cleaves big endothelin-1 (big ET-1) at the proper site, between Trp21 and Val22, with maximum activity at pH 7.5 and with a Km of roughly 3 microM, to produce endothelin-1 (ET-1) and C-terminal peptide (CTP).	Cytidine Triphosphate	228-231	endothelin 1	Bos taurus	198-202
1753946-1	1991	The URA7 gene of Saccharomyces cerevisiae encodes CTP synthetase (EC 6.3.4.2) which catalyses the conversion of uridine 5"-triphosphate to cytidine 5"-triphosphate, the last step of the pyrimidine biosynthetic pathway.	Cytidine Triphosphate	139-163	CTP synthase URA7	Saccharomyces cerevisiae S288C	4-8
1753946-4	1991	Gene disruption shows that URA7 is not an essential gene: the level of the intracellular CTP pool is roughly the same in the deleted and the wild-type strains, suggesting that an alternative pathway for CTP synthesis exists in yeast.	Cytidine Triphosphate	89-92	CTP synthase URA7	Saccharomyces cerevisiae S288C	27-31
1753946-4	1991	Gene disruption shows that URA7 is not an essential gene: the level of the intracellular CTP pool is roughly the same in the deleted and the wild-type strains, suggesting that an alternative pathway for CTP synthesis exists in yeast.	Cytidine Triphosphate	203-206	CTP synthase URA7	Saccharomyces cerevisiae S288C	27-31
1676683-6	1991	CTP has a TGase-inhibitory potency equivalent to that of ATP, whereas GTP and UTP possess about 50% of the inhibitory activity of ATP.	Cytidine Triphosphate	0-3	transglutaminase 1	Homo sapiens	10-15
1657910-1	1991	Intracellular distribution and characteristics of CTP:ethanolaminephosphate cytidylyltransferase.	Cytidine Triphosphate	50-53	ethanolamine-phosphate cytidylyltransferase	Ricinus communis	54-96
1657910-2	1991	The intracellular distribution and catalytic properties of CTP: ethanolaminephosphate cytidylyltransferase from endosperm of castor bean (Ricinus communis L. var.	Cytidine Triphosphate	59-62	ethanolamine-phosphate cytidylyltransferase	Ricinus communis	64-106
1838790-3	1991	The enzyme hydrolyzed ATP with a Km of 0.34 mM for Ca2+ ATPase and 0.48 mM for Mg2+ ATPase; various nucleoside triphosphate such as ITP, CTP, GTP, and UTP were also hydrolyzed.	Cytidine Triphosphate	137-140	carbonic anhydrase 2	Rattus norvegicus	51-62
1888777-2	1991	CDP-DAG is itself synthesized from phosphatidic acid and CTP.	Cytidine Triphosphate	57-60	cut-like homeobox 1	Rattus norvegicus	0-3
1829325-8	1991	Mg(2+)-induced contractions could be supported by CTP, which is a substrate for the actin-activated myosin adenosinetriphosphatase but not the MLC kinase.	Cytidine Triphosphate	50-53	myosin light chain 1	Sus scrofa	143-146
11536487-5	1991	The cyanamide-mediated production of CDP-ethanolamine was carried out by reacting a mixture of ethanolamine phosphate and CTP for 24 h at 70 degrees C.  The separation and identification of the reaction products was carried out by paper chromatography, thin-layer chromatography, high performance thin-layer chromatography, high performance liquid chromatography, both normal and reverse-phase, UV spectroscopy, enzymatic assays, and acid hydrolysis.	Cytidine Triphosphate	122-125	cut like homeobox 1	Homo sapiens	37-40