PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16584175-2	2006	Several approaches were utilized to investigate how two physiological substrates, cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol, interact with CYP27A1.	5beta-cholestane-3alpha	98-121	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	158-165
12569201-8	2003	We demonstrate that 5beta-cholestane-3alpha,7alpha,12alpha-triol (triol), a cholesterol-derived CYP3A substrate, is a potent PXR agonist that effectively induces cyp3a expression in mice.	5beta-cholestane-3alpha	20-43	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	96-101
12569201-8	2003	We demonstrate that 5beta-cholestane-3alpha,7alpha,12alpha-triol (triol), a cholesterol-derived CYP3A substrate, is a potent PXR agonist that effectively induces cyp3a expression in mice.	5beta-cholestane-3alpha	20-43	nuclear receptor subfamily 1, group I, member 2	Mus musculus	125-128
12569201-8	2003	We demonstrate that 5beta-cholestane-3alpha,7alpha,12alpha-triol (triol), a cholesterol-derived CYP3A substrate, is a potent PXR agonist that effectively induces cyp3a expression in mice.	5beta-cholestane-3alpha	20-43	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	162-167
9931427-0	1999	Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes.	5beta-cholestane-3alpha	81-104	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-24
9931427-11	1999	A strong correlation was observed between formation of 25-hydroxylated 5beta-cholestane-3alpha,7alpha,12alpha-triol and CYP3A levels (r2=0.96).	5beta-cholestane-3alpha	71-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	120-125
9931427-15	1999	From these results, it can be concluded that CYP3A4 is the predominant enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha, 7alpha,12alpha-triol in human liver microsomes.	5beta-cholestane-3alpha	114-137	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51
29452159-7	2018	The requirement for CYP27A1 for their formation by mitochondria was confirmed by the inhibition of their synthesis by 5beta-cholestane-3alpha,7alpha,12alpha-triol, an intermediate in bile acid synthesis which serves as an efficient competitive substrate for CYP27A1.	5beta-cholestane-3alpha	118-141	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	20-27
762246-1	1979	Cholic acid biosynthesis is defective in individuals with cerebrotendinous xanthomatosis (CTX) and is associated with the excretion of 5beta-cholestane-3alpha,7alpha, 12alpha,25-tetrol, an intermediate in the 25-hydroxylation pathway of cholic acid in CTX.	5beta-cholestane-3alpha	135-158	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	252-255
762246-9	1979	Furthermore, an appreciable amount of (3)H label was present in the 5beta-cholestane-3alpha,7alpha, 12alpha,25-tetrol isolated from the bile of the subjects with CTX.	5beta-cholestane-3alpha	68-91	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	162-165
762246-11	1979	The rate of the 25-hydroxylation of 5beta-cholestane-3alpha,7alpha, 12alpha-triol in CTX patients was comparable to that in the controls.	5beta-cholestane-3alpha	36-59	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	85-88
762246-12	1979	Similarly, the transformation of 5beta-cholestane-3alpha,7alpha, 12alpha,24S,25-pentol to cholic acid, catalyzed by soluble enzymes, proceeded at approximately equal rates in CTX and in control individuals.	5beta-cholestane-3alpha	33-56	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	175-178
762246-13	1979	On the other hand, the rate of 5beta-cholestane-3alpha,7alpha, 12alpha,24S,25-pentol formation was about four times greater in the control subjects than in the CTX patients.The results of the in vivo as well as the in vitro experiments suggest that the site of the enzymatic defect in CTX is at the 24S-hydroxylation of 5beta-cholestane-3alpha,7alpha, 12alpha,25-tetrol.	5beta-cholestane-3alpha	31-54	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	160-163
950499-9	1976	Isocitrate- and NADPH-dependent 26-hydroxylation of exogenous 5beta-cholestane-3alpha,7alpha,12alpha-triol differed from that of exogenous cholesterol in response to Mg2+ and Ca2+.	5beta-cholestane-3alpha	62-85	mucin 7, secreted	Homo sapiens	166-169
950499-10	1976	26-Hydrocylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol was stimulated by Mg2+ in low concentrations but inhibited by Mg2+ and Ca2+ in high concentrations.	5beta-cholestane-3alpha	20-43	mucin 7, secreted	Homo sapiens	83-86
950499-10	1976	26-Hydrocylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol was stimulated by Mg2+ in low concentrations but inhibited by Mg2+ and Ca2+ in high concentrations.	5beta-cholestane-3alpha	20-43	mucin 7, secreted	Homo sapiens	127-130
4385432-4	1968	7alpha-Hydroxycholest-4-en-3-one was metabolized into 7alpha-12alpha-dihydroxycholest-4-en-3-one in the presence of microsomal fraction fortified with NADPH and into 5beta-cholestane-3alpha,7alpha-diol in the presence of 100,000 g supernatant fluid.	5beta-cholestane-3alpha	166-189	2,4-dienoyl-CoA reductase 1	Homo sapiens	151-156
29452159-7	2018	The requirement for CYP27A1 for their formation by mitochondria was confirmed by the inhibition of their synthesis by 5beta-cholestane-3alpha,7alpha,12alpha-triol, an intermediate in bile acid synthesis which serves as an efficient competitive substrate for CYP27A1.	5beta-cholestane-3alpha	118-141	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	258-265