PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21353609-8	2011	Agps is a peroxisomal enzyme which catalyzes the formation of the ether bond during the synthesis of ether lipids.	ether lipids	101-113	alkylglycerone phosphate synthase	Mus musculus	0-4
10386321-2	1999	Milk fat contains a number of components, such as conjugated linoleic acid, sphingomyelin, butyric acid, ether lipids, beta-carotene, and vitamins A and D that have anticancer potential.	ether lipids	105-117	Weaning weight-maternal milk	Bos taurus	0-4
20714431-1	2010	Alkylglycerols (alkyl-Gro) are ether lipids abundant in the liver of some elasmobranch fish species such as ratfishes and some sharks.	ether lipids	31-43	chemokine (C-X-C motif) ligand 1	Mus musculus	22-25
19663381-5	2009	We have tested the cytotoxicity of the thio-ester pro anticancer ether lipids toward cancer cells, and the results showed that the cytotoxicity is indeed maintained upon sPLA(2) exposure.	ether lipids	65-77	phospholipase A2 group X	Homo sapiens	170-177
17472631-10	2007	The potential biomarkers for AOM-associated SRB, non-isoprenoidal ether lipids, increased below the SMTZ but this distribution reflected 16S rRNA gene sequences for JS1 and OP8 bacteria rather than those of SRB.	ether lipids	66-78	chaperonin containing TCP1 subunit 4	Homo sapiens	44-47
16279790-0	2005	Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue.	ether lipids	48-60	phospholipase A2 group IB	Homo sapiens	95-111
15027860-0	2004	Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs.	ether lipids	31-43	phospholipase A2 group IB	Homo sapiens	56-72
20036307-1	2011	Alkylglycerols (alkyl-Gro) are ether lipids abundant in shark liver oil (SLO), and oral SLO or alkyl-Gro mix from this source have several in vivo biological activities including stimulation of haematopoiesis an immunological defences, or anti-tumour and anti-metastasis activities in vivo.	ether lipids	31-43	chemokine (C-X-C motif) ligand 1	Mus musculus	22-25
19663381-2	2009	A drug delivery system based on the triggered release of therapeutics from sPLA(2)-sensitive liposomes constituted of pro anticancer ether lipids, which become cytotoxic upon sPLA(2)-catalyzed hydrolysis has previously been established.	ether lipids	133-145	phospholipase A2 group X	Homo sapiens	75-82
19663381-2	2009	A drug delivery system based on the triggered release of therapeutics from sPLA(2)-sensitive liposomes constituted of pro anticancer ether lipids, which become cytotoxic upon sPLA(2)-catalyzed hydrolysis has previously been established.	ether lipids	133-145	phospholipase A2 group X	Homo sapiens	175-182
10226541-8	1999	These results indicate that change of the localization of HSP27 may play an important role as a component of the signal transduction pathways affected by ether lipids.	ether lipids	154-166	heat shock protein family B (small) member 1	Homo sapiens	58-63
1446057-0	1992	Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo testing of ether lipids and their derivatives.	ether lipids	97-109	metallothionein 1I, pseudogene	Homo sapiens	50-63
8907240-3	1996	We have synthesized NBD-labeled ether lipids as substrates for measuring enzyme activities of the PAF cycle and of lysosomal phospholipase A2 (PLA2).	ether lipids	32-44	PCNA-associated factor	Bos taurus	98-101
8907240-3	1996	We have synthesized NBD-labeled ether lipids as substrates for measuring enzyme activities of the PAF cycle and of lysosomal phospholipase A2 (PLA2).	ether lipids	32-44	phospholipase A2 group XV	Bos taurus	115-141
1311590-0	1992	Modulation of ATPase activity by cholesterol and synthetic ether lipids in leukemic cells.	ether lipids	59-71	dynein axonemal heavy chain 8	Homo sapiens	14-20
1324692-7	1992	PAF antagonists (WEB 2086, CV 3988, triazolam, and SRI 63,441) blocked the action of the four ether lipids on platelets, while SRI 63,441 blocked the antineoplastic activity of the ether lipids on WEHI-3B and HL-60 cells.	ether lipids	94-106	patchy fur	Mus musculus	0-3
1324692-7	1992	PAF antagonists (WEB 2086, CV 3988, triazolam, and SRI 63,441) blocked the action of the four ether lipids on platelets, while SRI 63,441 blocked the antineoplastic activity of the ether lipids on WEHI-3B and HL-60 cells.	ether lipids	181-193	patchy fur	Mus musculus	0-3
1446057-4	1992	MT-1 and MT-3 proved to be sensitive to conventional cytostatic drugs used for treatment of mammary carcinomas; striking is their sensitivity to ether lipids.	ether lipids	145-157	metallothionein 1I, pseudogene	Homo sapiens	0-13
9029184-1	1997	We studied the cytotoxic effects of two ether lipids, a relatively new class of anticancer drugs, on multidrug-resistant (MDR1) leukemia cells of patients with acute leukemias who had failed induction treatment.	ether lipids	40-52	ATP binding cassette subfamily B member 1	Homo sapiens	122-126
7549919-1	1995	We reported that phospholipids of interleukin-2 (IL-2)-dependent murine cytotoxic T lymphocytes (CTL) contained high amounts of ether lipids (Biochem.	ether lipids	128-140	interleukin 2	Mus musculus	34-47
7549919-1	1995	We reported that phospholipids of interleukin-2 (IL-2)-dependent murine cytotoxic T lymphocytes (CTL) contained high amounts of ether lipids (Biochem.	ether lipids	128-140	interleukin 2	Mus musculus	49-53
8424826-0	1993	The role of intracellular free calcium mobilization in the mechanism of action of antitumour ether lipids SRI 62-834 and ET18-OMe.	ether lipids	93-105	sorcin	Homo sapiens	106-109
2614262-0	1989	Structures of minor ether lipids isolated from the aceticlastic methanogen, Methanothrix concilii GP6.	ether lipids	20-32	glycoprotein VI platelet	Homo sapiens	98-101
34667295-0	2021	Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids.	ether lipids	133-145	fatty acyl-CoA reductase 1	Homo sapiens	89-93
35573699-2	2022	However, by up to 20%, a significant proportion of this lipid class carries an ether-linked fatty alcohol side chain at the sn-1 position, generally referred to as ether lipids, which shape their specific physicochemical properties.	ether lipids	164-176	solute carrier family 38 member 3	Homo sapiens	124-128
35169201-8	2022	Finally, lipidomic analysis revealed that loss of Pxmp4 decreased hepatic levels of the alkyldiacylglycerol class of neutral ether lipids, particularly those containing polyunsaturated fatty acids.	ether lipids	125-137	peroxisomal membrane protein 4	Mus musculus	50-55
35537527-1	2022	Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids.	ether lipids	148-160	alkylglycerol monooxygenase	Mus musculus	48-75
35537527-1	2022	Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids.	ether lipids	148-160	alkylglycerol monooxygenase	Mus musculus	77-81
35014179-4	2022	Mechanistically, we show that the ER membrane-associated protein THEM6 regulates intracellular levels of ether lipids and is essential to trigger the induction of the ER stress response (UPR).	ether lipids	105-117	epiregulin	Homo sapiens	34-36
35014179-4	2022	Mechanistically, we show that the ER membrane-associated protein THEM6 regulates intracellular levels of ether lipids and is essential to trigger the induction of the ER stress response (UPR).	ether lipids	105-117	thioesterase superfamily member 6	Homo sapiens	65-70
35309067-1	2022	Ether lipids are a unique class of glycero- and glycerophospho-lipid that carry an ether or vinyl ether linked fatty alcohol at the sn-1 position of the glycerol backbone.	ether lipids	0-12	solute carrier family 38 member 3	Homo sapiens	132-136
32630389-7	2020	Ether lipids showed a prominent presence and accordingly, a decrease in glyceronephosphate O-acyltransferase (GNPAT) enzyme activity was found.	ether lipids	0-12	glyceronephosphate O-acyltransferase	Homo sapiens	72-108
2930525-4	1989	PKC inhibitors (e.g. polymyxin B and ether lipids) potently inhibited the PKC-enhanced D-PS fluorescence.	ether lipids	37-49	proline rich transmembrane protein 2	Homo sapiens	0-3
2930525-4	1989	PKC inhibitors (e.g. polymyxin B and ether lipids) potently inhibited the PKC-enhanced D-PS fluorescence.	ether lipids	37-49	proline rich transmembrane protein 2	Homo sapiens	74-77
2849926-0	1988	Inhibition of Na,K-ATPase and sodium pump by anticancer ether lipids and protein kinase C inhibitors ET-18-OCH3 and BM 41.440.	ether lipids	56-68	dynein axonemal heavy chain 8	Homo sapiens	19-25
3071807-4	1988	Formation of the 0-alkyl linkage between acyl-DHAP and the fatty alcohol in the initial step is catalyzed by alkyl-DHAP synthase; this reaction is unique to ether lipids.	ether lipids	157-169	alkylglycerone phosphate synthase	Homo sapiens	109-128
3444373-3	1987	In this report, we describe the first continuous assay for O-alkylglycerol monooxygenase (AGMO), the only enzyme known to cleave the O-alkyl bond in saturated ether lipids and ether phospholipids.	ether lipids	159-171	alkylglycerol monooxygenase	Rattus norvegicus	59-88
3444373-3	1987	In this report, we describe the first continuous assay for O-alkylglycerol monooxygenase (AGMO), the only enzyme known to cleave the O-alkyl bond in saturated ether lipids and ether phospholipids.	ether lipids	159-171	alkylglycerol monooxygenase	Rattus norvegicus	90-94
3444374-6	1987	Thirty-five different natural and synthetic ether lipids and their metabolites (including a thioether) were tested as substrates for AGMO.	ether lipids	44-56	alkylglycerol monooxygenase	Rattus norvegicus	133-137
3502166-0	1987	Differential effects of ether lipids on the activity and secretion of interleukin-1 and interleukin-2.	ether lipids	24-36	interleukin 1 alpha	Homo sapiens	70-83
3502166-0	1987	Differential effects of ether lipids on the activity and secretion of interleukin-1 and interleukin-2.	ether lipids	24-36	interleukin 2	Homo sapiens	88-101
33239752-0	2021	An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids.	ether lipids	118-130	fatty acyl-CoA reductase 1	Homo sapiens	74-78
32630389-7	2020	Ether lipids showed a prominent presence and accordingly, a decrease in glyceronephosphate O-acyltransferase (GNPAT) enzyme activity was found.	ether lipids	0-12	glyceronephosphate O-acyltransferase	Homo sapiens	110-115
24562909-8	2014	The Dictyostelium Dgat1, however, produces TAG, wax esters, and, most interestingly, also neutral ether lipids, which represent a significant constituent of lipid droplets.	ether lipids	98-110	diacylglycerol O-acyltransferase 1	Homo sapiens	18-23
32265321-1	2020	Ether lipids (ELs) are lipids characterized by the presence of either an ether linkage (alkyl lipids) or a vinyl ether linkage (i.e. plasmalogens [Pls]) at the sn1 position of the glycerol backbone and they are enriched in PUFAs at the sn2 position.	ether lipids	0-12	solute carrier family 38 member 3	Homo sapiens	160-163
32265321-1	2020	Ether lipids (ELs) are lipids characterized by the presence of either an ether linkage (alkyl lipids) or a vinyl ether linkage (i.e. plasmalogens [Pls]) at the sn1 position of the glycerol backbone and they are enriched in PUFAs at the sn2 position.	ether lipids	0-12	solute carrier family 38 member 5	Homo sapiens	236-239
25565205-8	2015	FAS knockdown in neutrophil-like HL-60 cells caused cell loss that was partially rescued by ether lipids.	ether lipids	92-104	fatty acid synthase	Mus musculus	0-3
30745342-1	2019	Fatty acyl-CoA reductase 1 (Far1) is a ubiquitously expressed peroxisomal membrane protein that generates the fatty alcohols required for the biosynthesis of ether lipids.	ether lipids	158-170	fatty acyl-CoA reductase 1	Homo sapiens	0-26
30745342-1	2019	Fatty acyl-CoA reductase 1 (Far1) is a ubiquitously expressed peroxisomal membrane protein that generates the fatty alcohols required for the biosynthesis of ether lipids.	ether lipids	158-170	fatty acyl-CoA reductase 1	Homo sapiens	28-32
22426352-5	2012	Mice deficient in the peroxisomal enzyme glyceronephosphate O-acyltransferase (GNPAT), essential for the synthesis of ether lipids, had significant alteration of the thymic maturation of iNKT cells and fewer iNKT cells in both thymus and peripheral organs, which confirmed the role of ether-bonded lipids as iNKT cell antigens.	ether lipids	118-130	glyceronephosphate O-acyltransferase	Mus musculus	79-84
23980144-3	2013	We show here that the metabolic enzyme alkylglyceronephosphate synthase (AGPS), a critical step in the synthesis of ether lipids, is up-regulated across multiple types of aggressive human cancer cells and primary tumors.	ether lipids	116-128	alkylglycerone phosphate synthase	Homo sapiens	73-77
23980144-5	2013	Taken together, our results reveal that AGPS, in addition to maintaining ether lipids, also controls cellular utilization of fatty acids, favoring the generation of signaling lipids necessary for promoting the aggressive features of cancer.	ether lipids	73-85	alkylglycerone phosphate synthase	Homo sapiens	40-44