PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33995104-0	2021	REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study.	D-methadone	0-8	brain derived neurotrophic factor	Homo sapiens	45-49
25012584-10	2015	Tonic block of Nav1.7 revealed a discrete stereo-selectivity with a higher potency for levomethadone than for dextromethadone.	D-methadone	110-125	sodium channel, voltage-gated, type IX, alpha	Mus musculus	15-21
24117196-9	2014	Dextromethadone and levomethadone induced discrete stereo-selective effects on Na(v)1.5 channels.	D-methadone	0-15	immunoglobulin lambda variable 2-18	Homo sapiens	79-87
31454827-0	2019	N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects.	D-methadone	41-52	CREB regulated transcription coactivator 1	Mus musculus	69-75
31454827-8	2019	D-methadone increased phospho-p70S6 kinase, a downstream target of mTORC1 in the mPFC, and intra-mPFC infusion of the selective mTORC1 inhibitor rapamycin blocked the antidepressant actions of d-methadone in the FUST and NSFT.	D-methadone	0-11	CREB regulated transcription coactivator 1	Mus musculus	67-73
31454827-8	2019	D-methadone increased phospho-p70S6 kinase, a downstream target of mTORC1 in the mPFC, and intra-mPFC infusion of the selective mTORC1 inhibitor rapamycin blocked the antidepressant actions of d-methadone in the FUST and NSFT.	D-methadone	193-204	CREB regulated transcription coactivator 1	Mus musculus	67-73
31454827-8	2019	D-methadone increased phospho-p70S6 kinase, a downstream target of mTORC1 in the mPFC, and intra-mPFC infusion of the selective mTORC1 inhibitor rapamycin blocked the antidepressant actions of d-methadone in the FUST and NSFT.	D-methadone	193-204	CREB regulated transcription coactivator 1	Mus musculus	128-134
31454827-9	2019	D-methadone administration also increased levels of the synaptic proteins, PSD95, GluA1, and Synapsin 1 and enhanced synaptic function in the mPFC.	D-methadone	0-11	discs large MAGUK scaffold protein 4	Homo sapiens	75-80
31454827-9	2019	D-methadone administration also increased levels of the synaptic proteins, PSD95, GluA1, and Synapsin 1 and enhanced synaptic function in the mPFC.	D-methadone	0-11	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	82-87
31454827-9	2019	D-methadone administration also increased levels of the synaptic proteins, PSD95, GluA1, and Synapsin 1 and enhanced synaptic function in the mPFC.	D-methadone	0-11	synapsin I	Homo sapiens	93-103
31454827-11	2019	These findings indicate that d-methadone induces rapid antidepressant actions through mTORC1-mediated synaptic plasticity in the mPFC similar to ketamine.	D-methadone	29-40	CREB regulated transcription coactivator 1	Mus musculus	86-92