PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2452210-3	1988	The addition of tannic acid to the staining procedure renders the elastin matrix extremely electron dense and easily located even at low scanning power.	Tannins	16-27	elastin	Mus musculus	66-73
2505942-0	1989	Inhibition of human placenta aldose reductase by tannic acid.	Tannins	49-60	aldo-keto reductase family 1 member B	Homo sapiens	29-45
2505942-1	1989	Tannic acid was found to be a highly potent inhibitor of human placenta aldose reductase.	Tannins	0-11	aldo-keto reductase family 1 member B	Homo sapiens	72-88
3492267-5	1987	Of the plant phenols studied tannic acid was found to be the most potent inhibitor of epidermal AHH activity.	Tannins	29-40	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	96-99
3231593-4	1988	The content of tannic acid in dried cooked beans was: 284.9 in white, 834.5 in red, 620.2 in the white:black mixture, 1,021 in Ipala black and 1,009 mg/100 g in the Jalpatagua black bean.	Tannins	15-26	brain expressed associated with NEDD4 1	Homo sapiens	43-47
3624155-6	1987	(b) Elastin, stainable with tannic acid, was noted electronmicroscopically in both endothelial and smooth muscle cells.	Tannins	28-39	elastin	Homo sapiens	4-11
3574755-0	1987	Ultrastructural demonstration of oxytocin and vasopressin release sites in the neural lobe and median eminence of the rat by tannic acid and immunogold methods.	Tannins	125-136	arginine vasopressin	Rattus norvegicus	46-57
3574755-3	1987	Release of the contents of these OXT and AVP NSG by exocytosis has been clearly demonstrated with the tannic acid-Ringer incubation method in axon terminals of the neural lobe and in varicose fibres with OXT and AVP NSG in the internal zone of the ME.	Tannins	102-113	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	33-36
3103715-2	1987	Tannic acid has been used in the present study as an electron-dense stain to follow the secretory process in thrombin-stimulated platelets.	Tannins	0-11	coagulation factor II, thrombin	Homo sapiens	109-117
3103715-4	1987	Examination of platelets fixed at short intervals after exposure to thrombin and incubated in solutions containing tannic acid revealed electron-dense deposits of osmium not apparent in resting platelets.	Tannins	115-126	coagulation factor II, thrombin	Homo sapiens	68-76
3492267-10	1987	Further in vivo studies showed that a single topical application of tannic acid, quercetin, and myricetin greatly diminished epidermal AHH (53-65%), ethoxycoumarin O-deethylase (30-68%), and ethoxyresorufin O-deethylase (66-97%) activities whereas anthraflavic acid was ineffective in this regard even when repeatedly applied.	Tannins	68-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	135-138
2432707-1	1986	A histological study of plastic semithin hippocampal sections after the treatment of myosin with tannic acid and detergent and then with subfragment-1 has shown the neuronal dendrites to be covered with dark spine-like thickenings.	Tannins	97-108	myosin heavy chain 14	Homo sapiens	85-91
3789751-5	1986	We found that a calmodulin antagonist, quercetin, anti-inflammatory agents and tannic acids were able to act as new anti-tumor promoters.	Tannins	79-91	calmodulin 2	Mus musculus	16-26
3999137-5	1985	It also indicates that in projection down the a axis, two molecules of myosin subfragment-1 lie almost directly on top of one another except for a translation of about 9 A along c. Small crystals were fixed and embedded in the presence of tannic acid, and thin sections were cut perpendicular to each of the three crystallographic axes.	Tannins	239-250	myosin heavy chain 14	Homo sapiens	71-77
3920681-0	1985	Inhibitory effects of tannic acid and benzophenone on soybean lipoxygenase and ram seminal vesicle cyclooxygenase.	Tannins	22-33	linoleate 9S-lipoxygenase-4	Glycine max	62-74
3920681-1	1985	Soybean lipoxygenase and cyclooxygenase from ram seminal vesicles were inhibited by tannic acid and the apparent ID50"s were 7.5 x 10(-7) M and 6 x 10(-6) M, respectively.	Tannins	84-95	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3920681-2	1985	The inhibition of lipoxygenase by tannic acid was noncompetitive.	Tannins	34-45	linoleate 9S-lipoxygenase-4	Glycine max	18-30
2580817-1	1985	A modification of the tannic acid-metal salt method was applied as an ultrastructural stain for elastin.	Tannins	22-33	elastin	Rattus norvegicus	96-103
4037374-2	1985	Fixation of glycosaminoglycans was performed by the use of acridine orange and elastin was identified by staining thin sections with tannic acid and uranyl acetate.	Tannins	133-144	elastin	Mus musculus	79-86
2412991-2	1985	The tannic acid-phosphomolybdic acid-Levanol (Supranol) Fast Cyanine 5RN (TP-L) procedure for staining muscle cells and blood platelets was used because, with this method, proteins of the myosin-fibrin group should be selectively stained.	Tannins	4-15	myosin heavy chain 14	Homo sapiens	188-194
2412991-7	1985	Myosin staining by the TP-L method depended on the pH of the tannic-acid solution used.	Tannins	61-72	myosin heavy chain 14	Homo sapiens	0-6
2580817-7	1985	Sequential treatments of osmicated specimens with tannic acid pH 7.0-9.0, and uranyl acetate, pH 4.1, enhanced the density of the elastin intensely, increased collagen staining moderately, but hardly increased the density of nuclei and microfibrils.	Tannins	50-61	elastin	Rattus norvegicus	130-137
2580817-8	1985	In elastase-digested osmicated specimens, all tannic acid (pH 7.0)-uranyl acetate-reactive elastin was selectively removed.	Tannins	46-57	elastin	Rattus norvegicus	91-98
617949-4	1977	The AChE inactivating effect of substances such as tannic acid and glutaraldehyde, among others, might be due to a non-specific damage of the RBC membrane.	Tannins	51-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
6384237-3	1984	In thin sections prepared with tannic acid, very thin filaments connected myosin filaments to actin filaments.	Tannins	31-42	myosin heavy chain 14	Homo sapiens	74-80
6229546-2	1984	The use of tannic acid stain and quick-freeze techniques revealed several thrombin-induced morphologic changes.	Tannins	11-22	coagulation factor II, thrombin	Homo sapiens	74-82
6185461-1	1982	Transmission electron micrographs of unactivated platelets, adenosine diphosphate-induced platelet aggregates and thrombin-induced platelet clots, prepared using a tannic acid fixative/stain, reveal characteristic lamellar bodies.	Tannins	164-175	coagulation factor II, thrombin	Homo sapiens	114-122
6170451-7	1981	Tannic acid fixation allowed the demonstration of filaments within the lamina rara interna, connecting the lamina densa with plasmalemma of preameloblasts.	Tannins	0-11	retinoic acid receptor, alpha	Mus musculus	78-82
6474594-0	1984	Trigonal catalase crystals: a new molecular packing assignment obtained from sections preserved with tannic acid.	Tannins	101-112	catalase	Homo sapiens	9-17
6842587-8	1983	Tannic acid alone was also found to serve as a suitable medium for preserving catalase crystals to a resolution of 3 X 7 A as judged by electron diffraction.	Tannins	0-11	catalase	Homo sapiens	78-86
6842587-9	1983	Overall, we demonstrate that projections obtained from thin sections of catalase crystals embedded in the presence of tannic acid can provide a reliable, negatively contrasted representation of the protein structure to 20 A resolution.	Tannins	118-129	catalase	Homo sapiens	72-80
448068-1	1979	Tannic acid-treated SRBC, incubated with increasing concentrations of C5 (Etan-C5) can be attached to C3 receptor-carrying (Raji) cells.	Tannins	0-11	complement C5	Homo sapiens	70-72
448068-1	1979	Tannic acid-treated SRBC, incubated with increasing concentrations of C5 (Etan-C5) can be attached to C3 receptor-carrying (Raji) cells.	Tannins	0-11	complement C5	Homo sapiens	74-81
457745-6	1979	Electron microscopy of thin sections of the MAP2-saturated microtubules fixed in the presence of tannic acid demonstrates a striking axial periodicity of 32 +/- 8 nm.	Tannins	97-108	microtubule associated protein 2	Bos taurus	44-48
399806-6	1979	(2) Elastin (El), which is the main constituent of the IEL, forms a wide, concentric, electron-lucent, tannic-acid-stainable zone.	Tannins	103-114	elastin	Homo sapiens	4-11
33128352-0	2020	Molecular docking-assisted screening reveals tannic acid as a natural protein disulphide isomerase inhibitor with antiplatelet and antithrombotic activities.	Tannins	45-56	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	70-98
1148400-2	1975	Normal red cells and ACHE-deficient red cells are separated in accordance with their density and then exposed to trypsin, cephalothin and tannic acid.	Tannins	138-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	21-25
14077018-0	1963	THE PRECIPITATION OF ERYTHROPOIETIN FROM URINE BY MEANS OF TANNIC ACID.	Tannins	59-70	erythropoietin	Homo sapiens	21-35
13528207-0	1958	[Comparative study of bis-diazotized benzidine and of tannic acid in the hemagglutination reactions obtained with insulin preparations and with the sera of diabetics treated with insulin].	Tannins	54-65	insulin	Homo sapiens	114-121
33937595-4	2021	TA was loaded into PMI hydrogel network to enhance the mechanical properties of TAP hydrogels through multiple non-covalent interactions (break strength: 0.28-0.64 MPa; elongation at break: 650-930%), which could resist the local stress and maintain the structural integrity of wound dressings during applications.	Tannins	0-2	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	80-83
33721632-6	2021	Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) showed boric acid/tannic acid binding for all concentrations at pH = 7 and 9, whereas binding at pH = 5.0 was observed only at 20 g L-1 tannic acid.	Tannins	98-109	ATR serine/threonine kinase	Homo sapiens	70-73
33721632-8	2021	ATR-FTIR results indicated tetrahedral coordination of boron upon complexation to tannic acid with a monodentate mechanism.	Tannins	82-93	ATR serine/threonine kinase	Homo sapiens	0-3
33620584-4	2021	Herein, we developed ferrous-supply nano-carrier for ART based on tannic acid (TA) and ferrous ion (Fe(II)) coated on the zeolitic imidazolate framework-8 (ZIF) with ART encapsulated (TA-Fe/ART@ZIF) via coordination-driven self-assembly.	Tannins	66-77	artemin	Homo sapiens	53-56
33620584-4	2021	Herein, we developed ferrous-supply nano-carrier for ART based on tannic acid (TA) and ferrous ion (Fe(II)) coated on the zeolitic imidazolate framework-8 (ZIF) with ART encapsulated (TA-Fe/ART@ZIF) via coordination-driven self-assembly.	Tannins	79-81	artemin	Homo sapiens	53-56
33620584-4	2021	Herein, we developed ferrous-supply nano-carrier for ART based on tannic acid (TA) and ferrous ion (Fe(II)) coated on the zeolitic imidazolate framework-8 (ZIF) with ART encapsulated (TA-Fe/ART@ZIF) via coordination-driven self-assembly.	Tannins	184-186	artemin	Homo sapiens	53-56
33442969-0	2021	Tannic Acid (TA)-Functionalized Magnetic Nanoparticles for EpCAM-Independent Circulating Tumor Cell (CTC) Isolation from Patients with Different Cancers.	Tannins	0-11	epithelial cell adhesion molecule	Homo sapiens	59-64
33442969-0	2021	Tannic Acid (TA)-Functionalized Magnetic Nanoparticles for EpCAM-Independent Circulating Tumor Cell (CTC) Isolation from Patients with Different Cancers.	Tannins	13-15	epithelial cell adhesion molecule	Homo sapiens	59-64
33205940-4	2020	The hydrophobic chemotherapeutic, rapamycin (RAP), is self-assembled into the pure drug nanocore, and the metal-organic framework (MOF) shell based on coordination between Mn2+ and tannic acid (TA) is coated on the surface to coload an autophagy-inhibiting DNAzyme.	Tannins	181-192	regulatory associated protein of MTOR, complex 1	Mus musculus	45-48
33205940-4	2020	The hydrophobic chemotherapeutic, rapamycin (RAP), is self-assembled into the pure drug nanocore, and the metal-organic framework (MOF) shell based on coordination between Mn2+ and tannic acid (TA) is coated on the surface to coload an autophagy-inhibiting DNAzyme.	Tannins	194-196	regulatory associated protein of MTOR, complex 1	Mus musculus	45-48
33128352-3	2020	Molecular docking using plant polyphenols from dietary sources with cardiovascular benefits revealed TA as the most potent binding molecule with PDI active centre.	Tannins	101-103	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	145-148
33128352-4	2020	Surface plasmon resonance demonstrated that TA bound PDI with high affinity.	Tannins	44-46	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	53-56
33128352-5	2020	Using Di-eosin-glutathione disulphide fluorescence assay and PDI assay kit, we showed that TA inhibited PDI activity.	Tannins	91-93	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	61-64
33128352-5	2020	Using Di-eosin-glutathione disulphide fluorescence assay and PDI assay kit, we showed that TA inhibited PDI activity.	Tannins	91-93	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	104-107
33128352-6	2020	In isolated platelets, TA inhibited platelet aggregation stimulated by either GPVI or ITAM pathway agonists.	Tannins	23-25	glycoprotein 6 (platelet)	Mus musculus	78-82
54195-5	1975	Actin filaments were not observed in spindles of unglycerinated cells or in cells fixed in glutaraldehyde containing tannic acid, which negatively stains F-actin in situ and thus can be used to aid the localization of actin filaments in non-muscle cells.	Tannins	117-128	Actin 79B	Drosophila melanogaster	0-5
54195-5	1975	Actin filaments were not observed in spindles of unglycerinated cells or in cells fixed in glutaraldehyde containing tannic acid, which negatively stains F-actin in situ and thus can be used to aid the localization of actin filaments in non-muscle cells.	Tannins	117-128	Actin 79B	Drosophila melanogaster	154-161
54195-5	1975	Actin filaments were not observed in spindles of unglycerinated cells or in cells fixed in glutaraldehyde containing tannic acid, which negatively stains F-actin in situ and thus can be used to aid the localization of actin filaments in non-muscle cells.	Tannins	117-128	Actin 79B	Drosophila melanogaster	156-161
33652057-11	2021	Specifically, numerous NPs including flavonoids, gingerols, tannins, anthocyanins, triterpenes and alkaloids have been shown anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-choLinesterase properties.	Tannins	60-67	butyrylcholinesterase	Homo sapiens	186-200
33965762-3	2021	UPLC-DAD-MSn allowed the identification of 44 hydrolyzable tannins as single and mixed hexosides bearing galloyl, HHDP and tergalloyl units.	Tannins	59-66	moesin	Homo sapiens	9-12
33869154-10	2021	Most importantly, 1%HSA/10%TA- and 5%HSA/1%TA-coated scaffolds were able to reduce S. aureus colonization on the mPCL surface, by 99.8 +- 0.1% and 98.8 +- 0.6%, respectively, in comparison to the non-coated control specimens.	Tannins	27-29	polycystic kidney disease 2-like 1	Mus musculus	113-117
33869154-10	2021	Most importantly, 1%HSA/10%TA- and 5%HSA/1%TA-coated scaffolds were able to reduce S. aureus colonization on the mPCL surface, by 99.8 +- 0.1% and 98.8 +- 0.6%, respectively, in comparison to the non-coated control specimens.	Tannins	43-45	polycystic kidney disease 2-like 1	Mus musculus	113-117
33718665-3	2021	Typically, we combined chitosan (CS) with silk fibroin (SF) by cross-linking them through tannic acid (TA) to maintain the structural stability of the hydrogel, especially for wet tissue adhesion ability (shear adhesive strength = 29.66 +- 0.36 kPa).	Tannins	90-101	citrate synthase	Homo sapiens	33-35
33718665-3	2021	Typically, we combined chitosan (CS) with silk fibroin (SF) by cross-linking them through tannic acid (TA) to maintain the structural stability of the hydrogel, especially for wet tissue adhesion ability (shear adhesive strength = 29.66 +- 0.36 kPa).	Tannins	103-105	citrate synthase	Homo sapiens	33-35
33075706-0	2021	Colorimetric detection of Cr3+ in dietary supplements using a smartphone based on EDTA and tannic acid-modified silver nanoparticles.	Tannins	91-102	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	26-29
33278434-5	2021	The polysaccharides-based hydrogel composed of oxidized dextran (Dex) and hyaluronic acid-hydrazide (HA) was mixed with TA-modified microspheres to form the ultimate BDNF@TA-PLGA/Dex-HA hydrogel.	Tannins	120-122	brain derived neurotrophic factor	Homo sapiens	166-170
33278434-5	2021	The polysaccharides-based hydrogel composed of oxidized dextran (Dex) and hyaluronic acid-hydrazide (HA) was mixed with TA-modified microspheres to form the ultimate BDNF@TA-PLGA/Dex-HA hydrogel.	Tannins	171-173	brain derived neurotrophic factor	Homo sapiens	166-170
33278434-9	2021	The swelling and degradation behaviors of the Dex-HA hydrogel in vitro indicated the incorporation of TA into hydrogel matrix could improve the stability of the hydrogel matrix as well as extend the release time of BDNF from the matrix.	Tannins	102-104	brain derived neurotrophic factor	Homo sapiens	215-219
33425648-0	2021	In silico investigation of saponins and tannins as potential inhibitors of SARS-CoV-2 main protease (Mpro).	Tannins	40-47	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	101-105
33425648-3	2021	Isolated saponins and tannins were evaluated for antiviral activity against SARS-CoV-2 (Mpro) via Molecular Docking and it was observed that a handsome number of the phytochemicals had binding affinities much better than Remdesivir, Dexamethasone, and N3 inhibitor which were used as the standards in this study.	Tannins	22-29	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	88-92
33415017-0	2020	Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.	Tannins	0-11	viral main protease	None	61-80
33415017-0	2020	Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.	Tannins	0-11	transmembrane serine protease 2	Homo sapiens	98-105
33415017-6	2020	Here we show that screening of these compounds identified tannic acid a potent inhibitor of both SARS-CoV-2 Mpro and TMPRSS2.	Tannins	58-69	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	108-112
33415017-6	2020	Here we show that screening of these compounds identified tannic acid a potent inhibitor of both SARS-CoV-2 Mpro and TMPRSS2.	Tannins	58-69	transmembrane serine protease 2	Homo sapiens	117-124
33415017-7	2020	Molecular analysis demonstrated that tannic acid formed a thermodynamically stable complex with the two proteins at a KD of 1.1 mM for Mpro and 1.77 mM for TMPRSS2.	Tannins	37-48	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	135-139
33415017-7	2020	Molecular analysis demonstrated that tannic acid formed a thermodynamically stable complex with the two proteins at a KD of 1.1 mM for Mpro and 1.77 mM for TMPRSS2.	Tannins	37-48	transmembrane serine protease 2	Homo sapiens	156-163
33415017-8	2020	Tannic acid inhibited the activities of the two proteases with an IC50 of 13.4 mM for Mpro and 2.31 mM for TMPRSS2.	Tannins	0-11	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	86-90
33415017-8	2020	Tannic acid inhibited the activities of the two proteases with an IC50 of 13.4 mM for Mpro and 2.31 mM for TMPRSS2.	Tannins	0-11	transmembrane serine protease 2	Homo sapiens	107-114
33128352-7	2020	Flow cytometry showed that TA inhibited thrombin- or CRP-stimulated platelet activation, as reflected by reduced granule secretion and integrin activation.	Tannins	27-29	coagulation factor II	Mus musculus	40-48
33128352-7	2020	Flow cytometry showed that TA inhibited thrombin- or CRP-stimulated platelet activation, as reflected by reduced granule secretion and integrin activation.	Tannins	27-29	C-reactive protein, pentraxin-related	Mus musculus	53-56
33128352-11	2020	Therefore, we identified TA from natural polyphenols as a novel inhibitor of PDI function.	Tannins	25-27	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	77-80
33128352-2	2020	In this study, we reported that a PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI activity, platelet activation and thrombus formation.	Tannins	64-75	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	34-37
33128352-2	2020	In this study, we reported that a PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI activity, platelet activation and thrombus formation.	Tannins	64-75	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	91-94
33128352-2	2020	In this study, we reported that a PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI activity, platelet activation and thrombus formation.	Tannins	77-79	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	34-37
33128352-2	2020	In this study, we reported that a PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI activity, platelet activation and thrombus formation.	Tannins	77-79	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	91-94
32858160-0	2020	Tannic Acid, A Promising Anti-Photoaging Agent: Evidences of its Antioxidant and Anti-Wrinkle Potentials, and its Ability to Prevent Photodamage and MMP-1 Expression in L929 Fibroblasts Exposed to UVB.	Tannins	0-11	matrix metallopeptidase 1	Homo sapiens	149-154
33173965-8	2020	Additionally, TA treatment caused a notable decrease in the expression levels of cleaved caspase-3/caspase-3, Bax, p53 and Bad, while increasing Bcl-2 expression levels.	Tannins	14-16	caspase 3	Rattus norvegicus	89-98
33173965-8	2020	Additionally, TA treatment caused a notable decrease in the expression levels of cleaved caspase-3/caspase-3, Bax, p53 and Bad, while increasing Bcl-2 expression levels.	Tannins	14-16	caspase 3	Rattus norvegicus	99-108
33173965-8	2020	Additionally, TA treatment caused a notable decrease in the expression levels of cleaved caspase-3/caspase-3, Bax, p53 and Bad, while increasing Bcl-2 expression levels.	Tannins	14-16	BCL2 associated X, apoptosis regulator	Rattus norvegicus	110-113
33173965-8	2020	Additionally, TA treatment caused a notable decrease in the expression levels of cleaved caspase-3/caspase-3, Bax, p53 and Bad, while increasing Bcl-2 expression levels.	Tannins	14-16	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	115-118
33173965-8	2020	Additionally, TA treatment caused a notable decrease in the expression levels of cleaved caspase-3/caspase-3, Bax, p53 and Bad, while increasing Bcl-2 expression levels.	Tannins	14-16	BCL2, apoptosis regulator	Rattus norvegicus	145-150
33282174-5	2020	The inclusion of TA on HA brought the composites with enhanced osteogenesis and angiogenesis, evidenced by osteocalcin (OCN) and vascular endothelial growth factor (VEGF) immunohistochemical staining.	Tannins	17-19	bone gamma-carboxyglutamate protein	Rattus norvegicus	107-118
33282174-5	2020	The inclusion of TA on HA brought the composites with enhanced osteogenesis and angiogenesis, evidenced by osteocalcin (OCN) and vascular endothelial growth factor (VEGF) immunohistochemical staining.	Tannins	17-19	bone gamma-carboxyglutamate protein	Rattus norvegicus	120-123
33282174-5	2020	The inclusion of TA on HA brought the composites with enhanced osteogenesis and angiogenesis, evidenced by osteocalcin (OCN) and vascular endothelial growth factor (VEGF) immunohistochemical staining.	Tannins	17-19	vascular endothelial growth factor A	Rattus norvegicus	129-163
33282174-5	2020	The inclusion of TA on HA brought the composites with enhanced osteogenesis and angiogenesis, evidenced by osteocalcin (OCN) and vascular endothelial growth factor (VEGF) immunohistochemical staining.	Tannins	17-19	vascular endothelial growth factor A	Rattus norvegicus	165-169
32858160-9	2020	Moreover, TA treatment prevented cellular photodamage and subsequently photoaging, by inhibiting lipid peroxidation, depolarization of mitochondrial transmembrane potential, DNA damage, and MMP-1 expression, a protein closely related to the structural degeneration of the dermis extracellular matrix.	Tannins	10-12	matrix metallopeptidase 1	Homo sapiens	190-195
32858160-10	2020	In conclusion, the results indicate the potential of TA in act as anti-photoaging agent, due to its potent antioxidant, anti-collagenase and anti-elastase activities, and UV-absorption effects, and its ability in prevent oxidative stress, oxidative damages and MMP-1 induction in UVB-irradiated L929 fibroblasts.	Tannins	53-55	matrix metallopeptidase 1	Homo sapiens	261-266
32841772-4	2020	A method of Asymmetric Flow Field-Flow Fractionation (AF4) coupled with UV detection, multi-angle light scattering (MALS), and differential refractometer index (dRI) (AF4-UV-MALS-dRI) has been developed to analyse macromolecules, including tannins and polysaccharides, and macromolecular complexes, in red wine.	Tannins	240-247	AF4/FMR2 family member 1	Homo sapiens	54-57
32540526-0	2020	Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis.	Tannins	56-67	albumin	Homo sapiens	26-39
32841772-13	2020	Furthermore, our results have shown that AF4-UV-MALS-dRI could be an efficient technique to separate large size tannins as well as polysaccharides and macromolecular complexes.	Tannins	112-119	AF4/FMR2 family member 1	Homo sapiens	41-44
33048528-7	2020	Using transwell devices, we cytologically demonstrated that tannic acid liposome can successfully be transferred across the model of a blood-brain barrier made up of mouse brain microvascular endothelial cell bEnd.3 and effectively reduce Tau aggregation induced by fibrils of Tau peptide R3 in human neuroblastoma cell SK-N-SH.	Tannins	60-71	BEN domain containing 3	Mus musculus	209-215
33000240-0	2020	Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1-Nrf2/ARE signaling pathway in arsenic trioxide-toxicated rats.	Tannins	0-11	Kelch-like ECH-associated protein 1	Rattus norvegicus	94-99
33000240-0	2020	Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1-Nrf2/ARE signaling pathway in arsenic trioxide-toxicated rats.	Tannins	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
33000240-7	2020	In addition, TA treatment inhibited ATO-induced liver apoptosis and inflammatory responses, increased Bcl-2 protein expression level and reduced the levels of Bax, caspase-3, interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Tannins	13-15	BCL2, apoptosis regulator	Rattus norvegicus	102-107
33000240-7	2020	In addition, TA treatment inhibited ATO-induced liver apoptosis and inflammatory responses, increased Bcl-2 protein expression level and reduced the levels of Bax, caspase-3, interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Tannins	13-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	159-162
33000240-7	2020	In addition, TA treatment inhibited ATO-induced liver apoptosis and inflammatory responses, increased Bcl-2 protein expression level and reduced the levels of Bax, caspase-3, interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Tannins	13-15	caspase 3	Rattus norvegicus	164-173
33000240-7	2020	In addition, TA treatment inhibited ATO-induced liver apoptosis and inflammatory responses, increased Bcl-2 protein expression level and reduced the levels of Bax, caspase-3, interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Tannins	13-15	interleukin 1 alpha	Rattus norvegicus	175-197
33000240-7	2020	In addition, TA treatment inhibited ATO-induced liver apoptosis and inflammatory responses, increased Bcl-2 protein expression level and reduced the levels of Bax, caspase-3, interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Tannins	13-15	interleukin 6	Rattus norvegicus	199-203
33000240-7	2020	In addition, TA treatment inhibited ATO-induced liver apoptosis and inflammatory responses, increased Bcl-2 protein expression level and reduced the levels of Bax, caspase-3, interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha.	Tannins	13-15	tumor necrosis factor	Rattus norvegicus	208-241
33000240-8	2020	Furthermore, TA treatment increased the protein expression levels of Nrf2 and Keap1, HO-1, NQO1 and gamma-GCS.	Tannins	13-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	69-73
33000240-8	2020	Furthermore, TA treatment increased the protein expression levels of Nrf2 and Keap1, HO-1, NQO1 and gamma-GCS.	Tannins	13-15	Kelch-like ECH-associated protein 1	Rattus norvegicus	78-83
33000240-9	2020	The results demonstrated that TA has a protective effect on ATO-treated hepatic toxicity and that its underlying mechanism could be due to TA activation of the Keap1-Nrf2/ARE signaling pathway, to reduce oxidative stress, apoptosis and inflammation in ATO-intoxicated rats.	Tannins	30-32	Kelch-like ECH-associated protein 1	Rattus norvegicus	160-165
33000240-9	2020	The results demonstrated that TA has a protective effect on ATO-treated hepatic toxicity and that its underlying mechanism could be due to TA activation of the Keap1-Nrf2/ARE signaling pathway, to reduce oxidative stress, apoptosis and inflammation in ATO-intoxicated rats.	Tannins	30-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	166-170
33000240-9	2020	The results demonstrated that TA has a protective effect on ATO-treated hepatic toxicity and that its underlying mechanism could be due to TA activation of the Keap1-Nrf2/ARE signaling pathway, to reduce oxidative stress, apoptosis and inflammation in ATO-intoxicated rats.	Tannins	139-141	Kelch-like ECH-associated protein 1	Rattus norvegicus	160-165
33000240-9	2020	The results demonstrated that TA has a protective effect on ATO-treated hepatic toxicity and that its underlying mechanism could be due to TA activation of the Keap1-Nrf2/ARE signaling pathway, to reduce oxidative stress, apoptosis and inflammation in ATO-intoxicated rats.	Tannins	139-141	NFE2 like bZIP transcription factor 2	Rattus norvegicus	166-170
32841772-4	2020	A method of Asymmetric Flow Field-Flow Fractionation (AF4) coupled with UV detection, multi-angle light scattering (MALS), and differential refractometer index (dRI) (AF4-UV-MALS-dRI) has been developed to analyse macromolecules, including tannins and polysaccharides, and macromolecular complexes, in red wine.	Tannins	240-247	AF4/FMR2 family member 1	Homo sapiens	167-170
32372165-6	2020	Additionally, treatment with TA also impaired BLM-mediated increases in pro-fibrotic (transforming growth factor-beta1) and fibrotic markers (alpha-smooth muscle actin, vimentin, collagen 1 alpha and fibronectin) expression.	Tannins	29-31	transforming growth factor, beta 1	Mus musculus	86-118
32372165-6	2020	Additionally, treatment with TA also impaired BLM-mediated increases in pro-fibrotic (transforming growth factor-beta1) and fibrotic markers (alpha-smooth muscle actin, vimentin, collagen 1 alpha and fibronectin) expression.	Tannins	29-31	vimentin	Mus musculus	169-177
32372165-6	2020	Additionally, treatment with TA also impaired BLM-mediated increases in pro-fibrotic (transforming growth factor-beta1) and fibrotic markers (alpha-smooth muscle actin, vimentin, collagen 1 alpha and fibronectin) expression.	Tannins	29-31	fibronectin 1	Mus musculus	200-211
32372165-7	2020	Further investigation indicated that BLM-induced phosphorylation of Erk1/2 (extracellular signal-regulated kinases 1 and 2) in lungs was suppressed by TA treatment.	Tannins	151-153	mitogen-activated protein kinase 3	Mus musculus	68-74
32372165-7	2020	Further investigation indicated that BLM-induced phosphorylation of Erk1/2 (extracellular signal-regulated kinases 1 and 2) in lungs was suppressed by TA treatment.	Tannins	151-153	mitogen-activated protein kinase 3	Mus musculus	76-122
32884745-10	2020	Meanwhile, dietary 1.0% TA supplementation tended to up-regulate OCLN mRNA levels in the jejunum (P < 0.10) and 0.2% TA supplementation tended to up-regulate zonula occludens-1 (ZO-1) mRNA levels in the ileum (P < 0.10).	Tannins	117-119	zonula occludens 1	Sus scrofa	158-176
32884745-6	2020	The higher occludin expression and localization were observed in the duodenum, jejunum and ileum after supplementation with 0.2% or 1.0% TA (P < 0.05).	Tannins	137-139	occludin	Sus scrofa	11-19
32884745-9	2020	In the duodenum, both 0.2% and 1.0% TA groups had higher occludin (OCLN) mRNA and 0.2% TA group had higher zonula occludens-2 (ZO-2) level (P < 0.05).	Tannins	36-38	occludin	Sus scrofa	57-65
32884745-9	2020	In the duodenum, both 0.2% and 1.0% TA groups had higher occludin (OCLN) mRNA and 0.2% TA group had higher zonula occludens-2 (ZO-2) level (P < 0.05).	Tannins	36-38	occludin	Sus scrofa	67-71
32884745-10	2020	Meanwhile, dietary 1.0% TA supplementation tended to up-regulate OCLN mRNA levels in the jejunum (P < 0.10) and 0.2% TA supplementation tended to up-regulate zonula occludens-1 (ZO-1) mRNA levels in the ileum (P < 0.10).	Tannins	24-26	occludin	Sus scrofa	65-69
32422262-4	2020	Then tannic acid/CaII was anchored on the surface of chitin nanofiber sponge by layer-by-layer deposition based on the coordination complex of tannic acid and Ca2+.	Tannins	5-16	carbonic anhydrase 2	Homo sapiens	17-21
32422262-4	2020	Then tannic acid/CaII was anchored on the surface of chitin nanofiber sponge by layer-by-layer deposition based on the coordination complex of tannic acid and Ca2+.	Tannins	143-154	carbonic anhydrase 2	Homo sapiens	17-21
32534374-7	2020	We conclude that TA and PGG, but not simple phenolic acids, are effective PL inhibitors, likely due to their numerous hydroxyl groups, which promote phenolic-enzyme interactions.	Tannins	17-19	pancreatic lipase	Homo sapiens	74-76
32884745-10	2020	Meanwhile, dietary 1.0% TA supplementation tended to up-regulate OCLN mRNA levels in the jejunum (P < 0.10) and 0.2% TA supplementation tended to up-regulate zonula occludens-1 (ZO-1) mRNA levels in the ileum (P < 0.10).	Tannins	117-119	zonula occludens 1	Sus scrofa	178-182
32500408-10	2020	Further, LPS administration caused increased levels of TNF-alpha in all brain structures, and this was prevented in the cortex by TA treatment.	Tannins	130-132	tumor necrosis factor	Mus musculus	55-64
32709749-5	2020	Instead, we found that TA and EGCG mainly acted as fluorescence quenchers that rapidly suppress the fluorophores conjugated to annexin V, a phosphatidylserine-binding probe commonly used to report on TMEM16 CaPLSase activity.	Tannins	23-25	annexin A5	Homo sapiens	127-136
32709749-6	2020	These data demonstrate the false positive effects of TA and EGCG on inhibiting TMEM16F phospholipid scrambling and discourage the use of these polyphenols as CaPLSase inhibitors.	Tannins	53-55	anoctamin 6	Homo sapiens	79-86
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Tannins	193-204	albumin	Homo sapiens	50-85
30979692-14	2020	Secondary metabolites with a high BDNF expression belonged to flavonoids, xanthone, coumarines, tannin, naphtalenes, terpenoids and carotenoid skeleton.	Tannins	96-102	brain derived neurotrophic factor	Homo sapiens	34-38
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Tannins	193-204	hydroxyacid oxidase 1	Homo sapiens	87-90
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Tannins	206-208	hydroxyacid oxidase 1	Homo sapiens	87-90
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Tannins	275-277	albumin	Homo sapiens	50-85
32537936-3	2020	Here, the prodrug tirapazamine (TPZ)-loaded human serum albumin (HSA)-glucose oxidase (GOx) mixture is prepared and modified with a metal-polyphenol network composed of ferric ions (Fe3+ ) and tannic acid (TA), to obtain a self-amplified nanoreactor termed HSA-GOx-TPZ-Fe3+ -TA (HGTFT) for sustainable and cascade cancer therapy with exogenous H2 O2 production and TA-accelerated Fe3+ /Fe2+ conversion.	Tannins	275-277	hydroxyacid oxidase 1	Homo sapiens	87-90
32432582-8	2020	Finally, the PEG-LZM-polyphenol (tannic acid) hydrogel was demonstrated to successfully patch a rabbit myocardial defect by suturing for 4 weeks and improve the wound healing and heart function recovery compared to autologous muscle patches.	Tannins	33-44	lysozyme	Homo sapiens	17-20
32698426-3	2020	Tannic acid has been reported to present the activity against Influeneza A virus, Papilloma viruses, noroviruses, Herpes simplex virus type 1 and 2, and human immunodeficiency virus (HIV) as well as activity against both Gram-positive and Gram-negative bacteria as Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Enterococcus faecalis, Pseudomonas aeruginosa, Yersinia enterocolitica, Listeria innocua.	Tannins	0-11	type 1 and 2	None	135-147
32222693-5	2020	We report that TMEM16F inhibitors tannic acid (TA) and epigallocatechin-3-gallate (EGCG) inhibit LPA-induced PS exposure and calcium uptake at low micromolar concentrations; fluoxetine, an antidepressant and a known activator of TMEM16F, enhances these processes.	Tannins	34-45	anoctamin 6	Homo sapiens	15-22
32222693-5	2020	We report that TMEM16F inhibitors tannic acid (TA) and epigallocatechin-3-gallate (EGCG) inhibit LPA-induced PS exposure and calcium uptake at low micromolar concentrations; fluoxetine, an antidepressant and a known activator of TMEM16F, enhances these processes.	Tannins	34-45	anoctamin 6	Homo sapiens	229-236
32222693-5	2020	We report that TMEM16F inhibitors tannic acid (TA) and epigallocatechin-3-gallate (EGCG) inhibit LPA-induced PS exposure and calcium uptake at low micromolar concentrations; fluoxetine, an antidepressant and a known activator of TMEM16F, enhances these processes.	Tannins	47-49	anoctamin 6	Homo sapiens	15-22
32222693-5	2020	We report that TMEM16F inhibitors tannic acid (TA) and epigallocatechin-3-gallate (EGCG) inhibit LPA-induced PS exposure and calcium uptake at low micromolar concentrations; fluoxetine, an antidepressant and a known activator of TMEM16F, enhances these processes.	Tannins	47-49	anoctamin 6	Homo sapiens	229-236
32146384-0	2020	Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-kappaB and Nrf2 pathways.	Tannins	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	95-99
32146384-12	2020	CONCLUSION: TA ameliorates ATO-induced nephrotoxicity, which is related to the inhibition of oxidative stress, inflammation and apoptosis, potentially through the NF-kappaB/Nrf2 pathway.	Tannins	12-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	173-177
32146384-11	2020	Furthermore, TA treatment caused a significant decrease in NF-kappaB expression (P < 0.05), while increasing Nrf2 and Keap1 expressions (P < 0.05).	Tannins	13-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	109-113
32146384-11	2020	Furthermore, TA treatment caused a significant decrease in NF-kappaB expression (P < 0.05), while increasing Nrf2 and Keap1 expressions (P < 0.05).	Tannins	13-15	Kelch-like ECH-associated protein 1	Rattus norvegicus	118-123
32028059-2	2020	Composition and inhibition analyses suggested that tannic acid (TA), (-)-epicatechin (EC) and phlorizin (PH) were the main active constituents in YAP showing alpha-glucosidase inhibition.	Tannins	51-62	alpha-glucosidase	Malus domestica	158-175
32399817-0	2020	Tannic Acid Provides Neuroprotective Effects Against Traumatic Brain Injury Through the PGC-1alpha/Nrf2/HO-1 Pathway.	Tannins	0-11	PPARG coactivator 1 alpha	Rattus norvegicus	88-98
32399817-0	2020	Tannic Acid Provides Neuroprotective Effects Against Traumatic Brain Injury Through the PGC-1alpha/Nrf2/HO-1 Pathway.	Tannins	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-103
32399817-0	2020	Tannic Acid Provides Neuroprotective Effects Against Traumatic Brain Injury Through the PGC-1alpha/Nrf2/HO-1 Pathway.	Tannins	0-11	heme oxygenase 1	Rattus norvegicus	104-108
32399817-9	2020	Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI.	Tannins	10-12	PPARG coactivator 1 alpha	Rattus norvegicus	73-142
32399817-9	2020	Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI.	Tannins	10-12	PPARG coactivator 1 alpha	Rattus norvegicus	144-154
32399817-9	2020	Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI.	Tannins	10-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	160-194
32399817-9	2020	Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI.	Tannins	10-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	196-200
32399817-9	2020	Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI.	Tannins	10-12	heme oxygenase 1	Rattus norvegicus	254-270
32399817-9	2020	Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI.	Tannins	10-12	heme oxygenase 1	Rattus norvegicus	272-276
32399817-10	2020	Overall, our results suggest that TA effectively ameliorates the behavioral alterations, oxidative damage, mitochondrial impairment, and inflammation against TBI that may be attributed to activation of PGC-1alpha/Nrf-2/HO-1 signaling pathway.	Tannins	34-36	PPARG coactivator 1 alpha	Rattus norvegicus	202-212
32399817-10	2020	Overall, our results suggest that TA effectively ameliorates the behavioral alterations, oxidative damage, mitochondrial impairment, and inflammation against TBI that may be attributed to activation of PGC-1alpha/Nrf-2/HO-1 signaling pathway.	Tannins	34-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	213-218
32399817-10	2020	Overall, our results suggest that TA effectively ameliorates the behavioral alterations, oxidative damage, mitochondrial impairment, and inflammation against TBI that may be attributed to activation of PGC-1alpha/Nrf-2/HO-1 signaling pathway.	Tannins	34-36	heme oxygenase 1	Rattus norvegicus	219-223
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	toll-like receptor 4	Mus musculus	62-66
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	mitogen-activated protein kinase 14	Mus musculus	68-71
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	mitogen-activated protein kinase 14	Mus musculus	75-78
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-89
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	91-94
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	lymphocyte cytosolic protein 1	Mus musculus	110-116
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	caspase 3	Mus musculus	118-127
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	BCL2-associated X protein	Mus musculus	129-132
32499705-9	2020	Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH.	Tannins	31-33	B cell leukemia/lymphoma 2	Mus musculus	138-143
32499705-10	2020	These results indicate that TA protects against ISO-induced MF, possibly through its ability to suppress the TLR4-mediated NF-kappaB signaling pathway.	Tannins	28-30	toll-like receptor 4	Mus musculus	109-113
32499705-10	2020	These results indicate that TA protects against ISO-induced MF, possibly through its ability to suppress the TLR4-mediated NF-kappaB signaling pathway.	Tannins	28-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
32028059-2	2020	Composition and inhibition analyses suggested that tannic acid (TA), (-)-epicatechin (EC) and phlorizin (PH) were the main active constituents in YAP showing alpha-glucosidase inhibition.	Tannins	64-66	alpha-glucosidase	Malus domestica	158-175
32028059-5	2020	Interestingly, the constants that indicate binding interaction between alpha-glucosidase and TA, PH, EC, including reciprocal of competitive inhibition constant (1/Kic), fluorescence quenching constant (KFQ) and binding energy (Eb), were shown similar orders as TA > PH > EC, contrary to IC50 values.	Tannins	93-95	alpha-glucosidase	Malus domestica	71-88
32028059-5	2020	Interestingly, the constants that indicate binding interaction between alpha-glucosidase and TA, PH, EC, including reciprocal of competitive inhibition constant (1/Kic), fluorescence quenching constant (KFQ) and binding energy (Eb), were shown similar orders as TA > PH > EC, contrary to IC50 values.	Tannins	262-264	alpha-glucosidase	Malus domestica	71-88
31979292-0	2020	Tannic Acid Promotes TRAIL-Induced Extrinsic Apoptosis by Regulating Mitochondrial ROS in Human Embryonic Carcinoma Cells.	Tannins	0-11	TNF superfamily member 10	Homo sapiens	21-26
31606677-0	2020	Immobilization of beta-galactosidase on tannic acid stabilized silver nanoparticles: A safer way towards its industrial application.	Tannins	40-51	galactosidase beta 1	Homo sapiens	18-36
31606677-1	2020	In this study, beta-galactosidase has been immobilized on tannic acid stabilized silver nanoparticles (AgNPs).	Tannins	58-69	galactosidase beta 1	Homo sapiens	15-33
31606677-5	2020	beta-galactosidase immobilized on tannic acid stabilized AgNPs (83.6% Immobilization yield) exhibited good activity with a high enzyme to carrier ratio as compared to the previous reports.	Tannins	34-45	galactosidase beta 1	Homo sapiens	0-18
31606677-10	2020	beta-galactosidase immobilized on tannic acid stabilized AgNPs are free from toxicity hazards of the linker molecules.	Tannins	34-45	galactosidase beta 1	Homo sapiens	0-18
31979292-6	2020	Through Western blotting and PCR, we demonstrate that TA inhibits cancer stem cell markers and the Wnt/beta-catenin signaling pathway in NCCIT cells and through a fluorescence-activated cell sorting analysis we demonstrated that TA induces sub-G1 cell cycle arrest and apoptosis.	Tannins	54-56	catenin beta 1	Homo sapiens	103-115
31979292-6	2020	Through Western blotting and PCR, we demonstrate that TA inhibits cancer stem cell markers and the Wnt/beta-catenin signaling pathway in NCCIT cells and through a fluorescence-activated cell sorting analysis we demonstrated that TA induces sub-G1 cell cycle arrest and apoptosis.	Tannins	229-231	catenin beta 1	Homo sapiens	103-115
31979292-8	2020	Moreover, ribonucleic acid sequencing data with TA in NCCIT cells show an elevation in TRAIL-induced extrinsic apoptosis, which we confirm by Western blotting and real-time PCR.	Tannins	48-50	TNF superfamily member 10	Homo sapiens	87-92
31979292-9	2020	The induction of human TRAIL also proves that TA can induce extrinsic apoptosis in NCCIT cells by regulating mROS.	Tannins	46-48	TNF superfamily member 10	Homo sapiens	23-28
31489459-0	2019	Tannic acid prevents macrophage-induced pro-fibrotic response in lung epithelial cells via suppressing TLR4-mediated macrophage polarization.	Tannins	0-11	toll like receptor 4	Homo sapiens	103-107
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Tannins	146-153	peroxisome proliferator activated receptor alpha	Homo sapiens	14-24
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Tannins	146-153	sirtuin 3	Homo sapiens	26-33
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Tannins	146-153	nuclear receptor subfamily 1 group H member 4	Homo sapiens	39-42
31546221-6	2019	Spectroscopic results showed that TA influenced the structure and conformation of fibrinogen.	Tannins	34-36	fibrinogen beta chain	Homo sapiens	82-92
30974029-3	2019	In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), alpha-glycosidase, alpha-amylase, and butyrylcholinesterase (BChE).	Tannins	17-28	butyrylcholinesterase	Homo sapiens	151-172
31386202-5	2019	The inhibitory effects of GA and TA on the cholesterol solubility in mixed micelles and liquid egg yolk exhibited a dose-dependent relationship (0.5-2.0 mg mL-1 ).	Tannins	33-35	L1 cell adhesion molecule	Mus musculus	156-160
31386202-6	2019	In cholate-binding tests, TA showed higher affinity for sodium cholate than GA at a concentration of 2.0 mg mL-1 , while no significant difference in the affinity for sodium deoxycholate was found between GA and TA.	Tannins	26-28	L1 cell adhesion molecule	Mus musculus	108-112
31450181-3	2019	The research purpose was to investigate the efficacy of MDR and its active ingredient tannic acid (TA) in ovalbumin (OVA)-induced AR mice model.	Tannins	86-97	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	106-115
31450181-3	2019	The research purpose was to investigate the efficacy of MDR and its active ingredient tannic acid (TA) in ovalbumin (OVA)-induced AR mice model.	Tannins	86-97	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	117-120
31450181-3	2019	The research purpose was to investigate the efficacy of MDR and its active ingredient tannic acid (TA) in ovalbumin (OVA)-induced AR mice model.	Tannins	86-97	ferredoxin reductase	Mus musculus	130-132
31450181-3	2019	The research purpose was to investigate the efficacy of MDR and its active ingredient tannic acid (TA) in ovalbumin (OVA)-induced AR mice model.	Tannins	99-101	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	106-115
31450181-3	2019	The research purpose was to investigate the efficacy of MDR and its active ingredient tannic acid (TA) in ovalbumin (OVA)-induced AR mice model.	Tannins	99-101	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	117-120
31450181-3	2019	The research purpose was to investigate the efficacy of MDR and its active ingredient tannic acid (TA) in ovalbumin (OVA)-induced AR mice model.	Tannins	99-101	ferredoxin reductase	Mus musculus	130-132
31450181-4	2019	OVA-challenged AR mice orally medicated MDR or its active ingredient TA daily for ten days.	Tannins	69-71	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-3
31450181-4	2019	OVA-challenged AR mice orally medicated MDR or its active ingredient TA daily for ten days.	Tannins	69-71	ferredoxin reductase	Mus musculus	15-17
31451948-3	2019	In this work, the structure of the porcine pancreatic alpha-amylase was modelled with the acarbose pentasaccharide inhibitor, and used in structure-based virtual screening simulations based on a library containing the structures of amylose (AMY), acarbose (ACA) and the more representative structures of condensed tannin (CTN) and hydrolysable tannin (HTN).	Tannins	314-320	amylase alpha 2A	Homo sapiens	43-67
31491512-0	2019	Inhibition of alpha-glucosidase activity and non-enzymatic glycation by tannic acid: Inhibitory activity and molecular mechanism.	Tannins	72-83	sucrase-isomaltase	Homo sapiens	14-31
31491512-2	2019	In this study, multispectroscopic and molecular docking techniques were employed to investigate the inhibition of tannic acid on alpha-glucosidase and glycation.	Tannins	114-125	sucrase-isomaltase	Homo sapiens	129-146
31491512-3	2019	Kinetics analyses revealed that tannic acid had a significant inhibition on alpha-glucosidase (IC50 = 0.35 +- 0.02 muM) in a reversible and mixed competitive manner.	Tannins	32-43	sucrase-isomaltase	Homo sapiens	76-93
31491512-4	2019	The results acquired from fluorescence quenching and ANS-binding fluorescence methods revealed that tannic acid could bind to alpha-glucosidase and reduce the hydrophobic area on the surface of the enzyme.	Tannins	100-111	sucrase-isomaltase	Homo sapiens	126-143
31491512-5	2019	In addition, synchronous fluorescence analysis showed that tannic acid decreased the hydrophobicity of alpha-glucosidase and changed the conformation of the enzyme.	Tannins	59-70	sucrase-isomaltase	Homo sapiens	103-120
31491512-8	2019	Moreover, the results of molecular docking showed the interaction between tannic acid and alpha-glucosidase was mainly driven by hydrogen bond, electrostatic, and hydrophobic interaction.	Tannins	74-85	sucrase-isomaltase	Homo sapiens	90-107
31489680-10	2019	Qualitative characterisation of APM indicated existence of alkaloids, terpenoids, coumarins, cardiac glycosides, phenols, flavonoids, saponins, tannins and sterols.	Tannins	144-151	alanyl aminopeptidase, membrane	Rattus norvegicus	32-35
31315458-1	2019	The aim of the study was to determine the relationship between anti-inflammatory effects of the natural polyphenolic compound tannic acid (CAS number: 1401-55-4) and myeloperoxidase (MPO) enzyme activity in paw edema model.	Tannins	126-137	myeloperoxidase	Rattus norvegicus	166-181
31315458-1	2019	The aim of the study was to determine the relationship between anti-inflammatory effects of the natural polyphenolic compound tannic acid (CAS number: 1401-55-4) and myeloperoxidase (MPO) enzyme activity in paw edema model.	Tannins	126-137	myeloperoxidase	Rattus norvegicus	183-186
31315458-10	2019	Serum and paw tissue MPO activities were decreased in treated groups with indomethacin and tannic acid according to formalin control group.	Tannins	91-102	myeloperoxidase	Rattus norvegicus	21-24
31315458-11	2019	Our study results suggest that tannic acid may contribute to the treatment of inflammation by decreasing MPO enzyme activity, but the molecular mechanism is still not clear.	Tannins	31-42	myeloperoxidase	Rattus norvegicus	105-108
31348976-3	2019	Herein, we developed drug-organics-inorganics self-assembled nanosystem (DFTA) with doxorubicin (DOX) as chemotherapeutic agent, ferric chloride (FeCl3) as ferroptosis inducer and tannic acid (TA) as activator of superoxide dismutase (SOD)-like reaction in intracellular cascade for the combined therapy in ER+ breast carcinoma.	Tannins	75-77	epiregulin	Homo sapiens	307-309
30974029-3	2019	In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), alpha-glycosidase, alpha-amylase, and butyrylcholinesterase (BChE).	Tannins	17-28	butyrylcholinesterase	Homo sapiens	174-178
30246289-0	2019	Tannic acid protects against experimental acute lung injury through downregulation of TLR4 and MAPK.	Tannins	0-11	toll like receptor 4	Homo sapiens	86-90
31163666-6	2019	Furthermore, we found the slight hemolysis of the TA coating caused by the lysed red blood cells and adsorption of protein, especially the clotting-related fibrinogen, resulted in excellent hemostasis performance of the TA coating in the blood clotting of an animal wound.	Tannins	50-52	fibrinogen beta chain	Homo sapiens	156-166
31358001-10	2019	RESULTS: Tannic acid inhibited TGF-beta-induced expression of collagen-1 and smooth muscle alpha-actin (SMA) as well as force generation by HLF.	Tannins	9-20	transforming growth factor alpha	Mus musculus	31-39
31358001-10	2019	RESULTS: Tannic acid inhibited TGF-beta-induced expression of collagen-1 and smooth muscle alpha-actin (SMA) as well as force generation by HLF.	Tannins	9-20	immunoglobulin mu binding protein 2	Mus musculus	104-107
31358001-10	2019	RESULTS: Tannic acid inhibited TGF-beta-induced expression of collagen-1 and smooth muscle alpha-actin (SMA) as well as force generation by HLF.	Tannins	9-20	hepatic leukemia factor	Mus musculus	140-143
31358001-11	2019	Tannic acid did not affect initial phosphorylation of Smad2 in response to TGF-beta, but significantly inhibited sustained Smad2 phosphorylation, which we recently described to be critical for TGF-beta-induced myofibroblast differentiation.	Tannins	0-11	SMAD family member 2	Mus musculus	123-128
31358001-11	2019	Tannic acid did not affect initial phosphorylation of Smad2 in response to TGF-beta, but significantly inhibited sustained Smad2 phosphorylation, which we recently described to be critical for TGF-beta-induced myofibroblast differentiation.	Tannins	0-11	transforming growth factor alpha	Mus musculus	193-201
31358001-12	2019	Accordingly, tannic acid inhibited Smad-dependent gene transcription in response to TGF-beta, as assessed using luciferase reporter for the activity of Smad-binding elements.	Tannins	13-24	transforming growth factor alpha	Mus musculus	84-92
31358001-13	2019	Finally, in mouse model of bleomycin-induced pulmonary fibrosis, therapeutic application of tannic acid resulted in a significant reduction of lung fibrosis, decrease in collagen-1 content and of Smad2 phosphorylation in the lungs.	Tannins	92-103	SMAD family member 2	Mus musculus	196-201
31358001-14	2019	CONCLUSIONS: This study demonstrates the anti-fibrotic effect of tannic acid in vitro and in vivo through a regulation of sustained Smad2 phosphorylation.	Tannins	65-76	SMAD family member 2	Mus musculus	132-137
31071434-6	2019	Bradykinin, chosen as a model, was incubated with increasing concentrations of 1,2,3,4,6-penta-O-galloyl-beta-d-glucose and tannic acid selected as reference of tannic compounds.	Tannins	124-135	kininogen 1	Homo sapiens	0-10
30722900-3	2019	It was found that binding of tannic acid, chlorogenic acid, caffeic acid and epicatechin with alpha-amylase is an exothermal process, with the binding constants in the order of tannic acid &gt; chlorogenic acid &gt; caffeic acid &gt; epicatechin.	Tannins	29-40	probable alpha-amylase 2	Malus domestica	94-107
30722900-3	2019	It was found that binding of tannic acid, chlorogenic acid, caffeic acid and epicatechin with alpha-amylase is an exothermal process, with the binding constants in the order of tannic acid &gt; chlorogenic acid &gt; caffeic acid &gt; epicatechin.	Tannins	177-188	probable alpha-amylase 2	Malus domestica	94-107
31017392-7	2019	Both the cell types showed significantly higher cellular uptake of QA-coated USIONPs compared to TA-coated USIONPs at 4, 24, and 72 h. Blocking studies indicated that P-selectin cell surface receptors, in part, mediated the cellular uptake of QA-coated USIONPs.	Tannins	97-99	selectin P	Homo sapiens	167-177
30724376-0	2019	Anti-neuroinflammatory effects of tannic acid against lipopolysaccharide-induced BV2 microglial cells via inhibition of NF-kappaB activation.	Tannins	34-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
30960532-1	2019	Tannin/cellulose microspheres (T/C) were successfully prepared via a facile homogeneous reaction in a water/oil (W/O) emulsion for removing Pb(II) ions from aqueous solution.	Tannins	0-6	submaxillary gland androgen regulated protein 3B	Homo sapiens	140-146
30960532-8	2019	The results suggested that tannin/cellulose microspheres could be a low-cost and effective adsorbent for removing Pb(II) ions from aqueous solution.	Tannins	27-33	submaxillary gland androgen regulated protein 3B	Homo sapiens	114-120
30960532-0	2019	Removing Pb(II) Ions from Aqueous Solution by a Promising Absorbent of Tannin-Immobilized Cellulose Microspheres.	Tannins	71-77	submaxillary gland androgen regulated protein 3B	Homo sapiens	9-15
30724376-7	2019	Collectively, the anti-inflammatory effects of tannic acid on LPS-induced BV2 microglial cells are attributed to the inhibition of ROS formation and the suppression of NF-kappaB pathway activation.	Tannins	47-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-177
30133338-1	2019	We identified a protein spot showing downregulation in the presence of Cryphonectria hypovirus 1 and tannic acid supplementation as a septin subunit with the highest homology to the Aspergillus nidulans aspA gene, an ortholog of the Saccharomyces cerevisiae Cdc11 gene.	Tannins	101-112	septin CDC11	Saccharomyces cerevisiae S288C	258-263
30445673-1	2018	In this study, a novel three-dimensional (3D) bone morphogenic protein-2 (BMP-2)-delivering tannylated polycaprolactone (PCL) (BMP-2/tannic acid (TA)/PCL) scaffold with anti-oxidant, anti-inflammatory, and osteogenic activities was fabricated via simple surface coating with TA, followed by the immobilization of BMP-2 on the TA-coated PCL scaffold.	Tannins	133-144	bone morphogenetic protein 2	Mus musculus	46-72
30265970-0	2018	A novel electrogenerated chemiluminescence biosensor for histone acetyltransferases activity analysis and inhibition based on mimetic superoxide dismutase of tannic acid assembled nanoprobes.	Tannins	158-169	superoxide dismutase 1	Homo sapiens	134-154
30960011-3	2018	In this study, catalase/ZIF-8 composites with a protective nanocoating were prepared by the controlled self-assembly of silanes or coordination complexes (tannic acid (TA) and Fe3+).	Tannins	155-166	catalase	Homo sapiens	15-23
30960011-3	2018	In this study, catalase/ZIF-8 composites with a protective nanocoating were prepared by the controlled self-assembly of silanes or coordination complexes (tannic acid (TA) and Fe3+).	Tannins	168-170	catalase	Homo sapiens	15-23
30383966-4	2018	In the ATP-overexpressed tumor cells, the outer shell MPN of GOx@ZIF@MPN was degraded into Fe(III) and tannic acid (TA) and the internal GOx was exposed.	Tannins	103-114	hydroxyacid oxidase 1	Homo sapiens	61-64
30383966-4	2018	In the ATP-overexpressed tumor cells, the outer shell MPN of GOx@ZIF@MPN was degraded into Fe(III) and tannic acid (TA) and the internal GOx was exposed.	Tannins	116-118	hydroxyacid oxidase 1	Homo sapiens	61-64
30473486-7	2019	Interestingly, TA abrogated occupancy of p300 on the sterol regulatory element in the fatty acid synthase and ATP-citrate lyase promoters, eventually inducing hypoacetylation of H3K9 and H3K36.	Tannins	15-17	E1A binding protein p300	Homo sapiens	41-45
30473486-7	2019	Interestingly, TA abrogated occupancy of p300 on the sterol regulatory element in the fatty acid synthase and ATP-citrate lyase promoters, eventually inducing hypoacetylation of H3K9 and H3K36.	Tannins	15-17	fatty acid synthase	Homo sapiens	86-105
30473486-7	2019	Interestingly, TA abrogated occupancy of p300 on the sterol regulatory element in the fatty acid synthase and ATP-citrate lyase promoters, eventually inducing hypoacetylation of H3K9 and H3K36.	Tannins	15-17	ATP citrate lyase	Homo sapiens	110-127
30473486-11	2019	Finally, we demonstrated the possibility that TA directly binds to p300 through docking simulation between ligand and protein.	Tannins	46-48	E1A binding protein p300	Homo sapiens	67-71
30139411-8	2018	For example, the effectiveness of tannins and essential oils is as yet controversial, with some studies showing no effects and others a positive impact on inhibiting the first step of BH of PUFA or, less commonly, the final step.	Tannins	34-41	PUFA	Bos taurus	190-194
30445673-1	2018	In this study, a novel three-dimensional (3D) bone morphogenic protein-2 (BMP-2)-delivering tannylated polycaprolactone (PCL) (BMP-2/tannic acid (TA)/PCL) scaffold with anti-oxidant, anti-inflammatory, and osteogenic activities was fabricated via simple surface coating with TA, followed by the immobilization of BMP-2 on the TA-coated PCL scaffold.	Tannins	133-144	bone morphogenetic protein 2	Mus musculus	74-79
30259036-0	2018	Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.	Tannins	0-11	pyruvate kinase M1/2	Homo sapiens	29-57
30259036-3	2018	In the present study, we used TA-functionalized magnetite nanoparticles to identify pyruvate kinase isoenzyme M2 (PKM2) as the direct target of TA.	Tannins	30-32	pyruvate kinase M1/2	Homo sapiens	84-112
30259036-3	2018	In the present study, we used TA-functionalized magnetite nanoparticles to identify pyruvate kinase isoenzyme M2 (PKM2) as the direct target of TA.	Tannins	30-32	pyruvate kinase M1/2	Homo sapiens	114-118
30466981-14	2018	A Rhodamine 123 assay and Calcein-AM assay in Caco-2 and CEM/ADR 5000, respectively, were used to detect P-gp inhibition by EGCG, curcumin, and tannic acid.	Tannins	144-155	phosphoglycolate phosphatase	Homo sapiens	105-109
29665059-4	2018	TA also prevented the TGF-beta1-induced alteration in the expression of two classes of genes involved in the remodeling of extracellular matrix (ECM) proteins, namely matrix metalloproteinases (Mmp-2 and -9) and tissue inhibitors of metalloproteinases (Timp-1 and -3).	Tannins	0-2	transforming growth factor beta 1	Homo sapiens	22-31
30466981-20	2018	Consistent with the combination results, tannic acid and curcumin decreased the activity of P-gp both in Caco-2 and CEM/ADR 5000.	Tannins	41-52	phosphoglycolate phosphatase	Homo sapiens	92-96
30466981-22	2018	CONCLUSION: Our results show that EGCG, curcumin, and tannic acid, when combined with doxorubicin, can exert synergism, mediated by a reduced activity of P-gp.	Tannins	54-65	phosphoglycolate phosphatase	Homo sapiens	154-158
30007881-0	2018	Binding interaction of sheep alpha-2-macroglobulin and tannic acid: A spectroscopic and thermodynamic study.	Tannins	55-66	alpha-2-macroglobulin	Ovis aries	29-50
30007881-4	2018	An attempt has been made to study the interaction of tannic acid with alpha-2-macroglobulin (alpha2M).	Tannins	53-64	alpha-2-macroglobulin	Ovis aries	70-91
30007881-4	2018	An attempt has been made to study the interaction of tannic acid with alpha-2-macroglobulin (alpha2M).	Tannins	53-64	alpha-2-macroglobulin	Ovis aries	93-100
30007881-6	2018	In the present study we explored the tannic acid-alpha2M interaction by number of spectroscopic techniques such as UV, fluorescence, CD and FTIR along with isothermal titration calorimetry.	Tannins	37-48	alpha-2-macroglobulin	Ovis aries	49-56
30007881-9	2018	Data of UV spectroscopy shows formation of alpha2M-tannic acid complex.	Tannins	51-62	alpha-2-macroglobulin	Ovis aries	43-50
30007881-11	2018	Analysis of CD and FTIR results suggest a minor conformational change in alpha2M on tannic acid binding.	Tannins	84-95	alpha-2-macroglobulin	Ovis aries	73-80
30007881-12	2018	Overall, tannic acid induces subtle conformation change in alpha2M structure resulting the loss of its proteinase inhibitory activity.	Tannins	9-20	alpha-2-macroglobulin	Ovis aries	59-66
30058211-5	2018	We investigated the combined tannic acid (TA) or epigallocatechin gallate (EGCG) with ferric chloride to stabilize elastin and prevent calcification.	Tannins	29-40	elastin	Homo sapiens	115-122
30058211-5	2018	We investigated the combined tannic acid (TA) or epigallocatechin gallate (EGCG) with ferric chloride to stabilize elastin and prevent calcification.	Tannins	42-44	elastin	Homo sapiens	115-122
30058211-6	2018	We found that the amount of TA/EGCG bound to elastin was in a time-dependent pattern and this reaction showed better efficiency in acidic condition and ethanol-water mixed solvents.	Tannins	28-30	elastin	Homo sapiens	45-52
30312029-0	2018	Tannic Acid Solution: A Better Fixative Solution Than Formalin for Elastin and Collagen-Toxic and Morphological Assessment.	Tannins	0-11	elastin	Homo sapiens	67-74
30312029-3	2018	Previous research showed that tannic acid (TA) in glutaraldehyde solution has the ability to stabilize elastin and collagen.	Tannins	30-41	elastin	Homo sapiens	103-110
30312029-3	2018	Previous research showed that tannic acid (TA) in glutaraldehyde solution has the ability to stabilize elastin and collagen.	Tannins	43-45	elastin	Homo sapiens	103-110
30112674-6	2018	Therefore, this study was aimed to explore the activity and cytotoxicity of tannic acid-modified silver nanoparticles, pure silver nanoparticles and pure gold nanoparticles against clinical strains of Acanthamoeba spp.	Tannins	76-87	histocompatibility minor 13	Homo sapiens	214-217
30112674-10	2018	In conclusion and based on the observed results, silver nanoparticle conjugation with tannic acid may be considered as potential agent against Acanthamoeba spp.	Tannins	86-97	histocompatibility minor 13	Homo sapiens	156-159
30126633-0	2018	Tannic acid inhibits NLRP3 inflammasome-mediated IL-1beta production via blocking NF-kappaB signaling in macrophages.	Tannins	0-11	NLR family pyrin domain containing 3	Homo sapiens	21-26
30126633-0	2018	Tannic acid inhibits NLRP3 inflammasome-mediated IL-1beta production via blocking NF-kappaB signaling in macrophages.	Tannins	0-11	interleukin 1 beta	Homo sapiens	49-57
30126633-3	2018	Here, we reported that tannic acid inhibited NLRP3 inflammasome activation by blocking NF-kappaB signaling to suppress IL-1beta secretion.	Tannins	23-34	NLR family pyrin domain containing 3	Homo sapiens	45-50
30126633-3	2018	Here, we reported that tannic acid inhibited NLRP3 inflammasome activation by blocking NF-kappaB signaling to suppress IL-1beta secretion.	Tannins	23-34	interleukin 1 beta	Homo sapiens	119-127
30126633-4	2018	We found that the BMDMs (bone marrow-derived macrophages cells) pre-treated with tannic acid blocked caspase-1 cleavage and inhibited IL-1beta secretion in a NLRP3-dependent manner, and suppressed NF-kappaB signaling activation by inhibiting NF-kappaB/P65 nuclear localization, suggesting that tannic acid inhibited NLRP3 inflammasome activation.	Tannins	81-92	caspase 1	Homo sapiens	101-110
30126633-4	2018	We found that the BMDMs (bone marrow-derived macrophages cells) pre-treated with tannic acid blocked caspase-1 cleavage and inhibited IL-1beta secretion in a NLRP3-dependent manner, and suppressed NF-kappaB signaling activation by inhibiting NF-kappaB/P65 nuclear localization, suggesting that tannic acid inhibited NLRP3 inflammasome activation.	Tannins	81-92	interleukin 1 beta	Homo sapiens	134-142
30126633-4	2018	We found that the BMDMs (bone marrow-derived macrophages cells) pre-treated with tannic acid blocked caspase-1 cleavage and inhibited IL-1beta secretion in a NLRP3-dependent manner, and suppressed NF-kappaB signaling activation by inhibiting NF-kappaB/P65 nuclear localization, suggesting that tannic acid inhibited NLRP3 inflammasome activation.	Tannins	81-92	NLR family pyrin domain containing 3	Homo sapiens	158-163
30126633-4	2018	We found that the BMDMs (bone marrow-derived macrophages cells) pre-treated with tannic acid blocked caspase-1 cleavage and inhibited IL-1beta secretion in a NLRP3-dependent manner, and suppressed NF-kappaB signaling activation by inhibiting NF-kappaB/P65 nuclear localization, suggesting that tannic acid inhibited NLRP3 inflammasome activation.	Tannins	81-92	NLR family pyrin domain containing 3	Homo sapiens	316-321
30126633-5	2018	These investigations revealed that tannic acid inhibited NLRP3 inflammasome activation via blocking NF-kappaB signaling in macrophages, providing us with evidence that tannic acid may be a potent inhibitor for NLRP3-driven diseases.	Tannins	35-46	NLR family pyrin domain containing 3	Homo sapiens	57-62
30126633-5	2018	These investigations revealed that tannic acid inhibited NLRP3 inflammasome activation via blocking NF-kappaB signaling in macrophages, providing us with evidence that tannic acid may be a potent inhibitor for NLRP3-driven diseases.	Tannins	35-46	NLR family pyrin domain containing 3	Homo sapiens	210-215
30126633-5	2018	These investigations revealed that tannic acid inhibited NLRP3 inflammasome activation via blocking NF-kappaB signaling in macrophages, providing us with evidence that tannic acid may be a potent inhibitor for NLRP3-driven diseases.	Tannins	168-179	NLR family pyrin domain containing 3	Homo sapiens	57-62
30126633-5	2018	These investigations revealed that tannic acid inhibited NLRP3 inflammasome activation via blocking NF-kappaB signaling in macrophages, providing us with evidence that tannic acid may be a potent inhibitor for NLRP3-driven diseases.	Tannins	168-179	NLR family pyrin domain containing 3	Homo sapiens	210-215
29665059-4	2018	TA also prevented the TGF-beta1-induced alteration in the expression of two classes of genes involved in the remodeling of extracellular matrix (ECM) proteins, namely matrix metalloproteinases (Mmp-2 and -9) and tissue inhibitors of metalloproteinases (Timp-1 and -3).	Tannins	0-2	matrix metallopeptidase 2	Homo sapiens	194-206
29665059-4	2018	TA also prevented the TGF-beta1-induced alteration in the expression of two classes of genes involved in the remodeling of extracellular matrix (ECM) proteins, namely matrix metalloproteinases (Mmp-2 and -9) and tissue inhibitors of metalloproteinases (Timp-1 and -3).	Tannins	0-2	TIMP metallopeptidase inhibitor 1	Homo sapiens	253-266
33445338-4	2018	Using the layer-by-layer (LbL) assembly technique with fibronectin, heparin, and tannic acid, we prepared a VEGF-incorporated multilayer film (VEGF film) that is smooth and stable and increases cell proliferation by up to 2.5 times that of the control group cells.	Tannins	81-92	vascular endothelial growth factor A	Homo sapiens	108-112
29478519-2	2018	This work aimed to study bovine serum albumin binding to phytic acid and tannic acid, and its influence on in vitro protein digestibility.	Tannins	73-84	albumin	Homo sapiens	32-45
29478519-4	2018	Results showed that high ionic strength promotes greater affinity between tannic acid and bovine serum albumin, and decreases in vitro protein digestibility.	Tannins	74-85	albumin	Homo sapiens	97-110
29683273-4	2018	To prevent infection, biocompatible nanocarriers of polypeptide-based block copolymer micelles are deposited onto the surfaces of PCL/Coll nanofibers using tannic acid as a binding partner.	Tannins	156-167	PHD finger protein 1	Homo sapiens	130-133
29665525-7	2018	Moreover, Ct values for HBB in tannic acid-spiked samples reached a maximum once, and inhibition decreased at higher concentrations.	Tannins	31-42	hemoglobin subunit beta	Homo sapiens	24-27
29594686-0	2018	Copper nanoclusters capped with tannic acid as a fluorescent probe for real-time determination of the activity of pyrophosphatase.	Tannins	32-43	inorganic pyrophosphatase 1	Homo sapiens	114-129
29518944-6	2018	Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression.	Tannins	0-11	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	59-109
29518944-6	2018	Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression.	Tannins	0-11	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	111-115
29518944-6	2018	Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression.	Tannins	0-11	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	121-148
29518944-6	2018	Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression.	Tannins	0-11	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	150-154
29518944-6	2018	Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression.	Tannins	0-11	activating transcription factor 4	Homo sapiens	194-198
29518944-6	2018	Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression.	Tannins	0-11	heat shock protein family A (Hsp70) member 5	Homo sapiens	200-203
29518944-6	2018	Tannic acid demonstrated activation of ER stress response (Protein kinase R-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme 1 (IRE1)) and altered its regulatory proteins (ATF4, Bip, and PDI) expression.	Tannins	0-11	prolyl 4-hydroxylase subunit beta	Homo sapiens	209-212
29518944-7	2018	Tannic acid treatment affirmed upregulation of apoptosis-associated markers (Bak, Bim, cleaved caspase 3, and cleaved PARP), while downregulation of pro-survival proteins (Bcl-2 and Bcl-xL).	Tannins	0-11	BCL2 like 11	Homo sapiens	82-85
29518944-7	2018	Tannic acid treatment affirmed upregulation of apoptosis-associated markers (Bak, Bim, cleaved caspase 3, and cleaved PARP), while downregulation of pro-survival proteins (Bcl-2 and Bcl-xL).	Tannins	0-11	collagen type XI alpha 2 chain	Homo sapiens	118-122
29518944-7	2018	Tannic acid treatment affirmed upregulation of apoptosis-associated markers (Bak, Bim, cleaved caspase 3, and cleaved PARP), while downregulation of pro-survival proteins (Bcl-2 and Bcl-xL).	Tannins	0-11	BCL2 apoptosis regulator	Homo sapiens	172-177
29518944-7	2018	Tannic acid treatment affirmed upregulation of apoptosis-associated markers (Bak, Bim, cleaved caspase 3, and cleaved PARP), while downregulation of pro-survival proteins (Bcl-2 and Bcl-xL).	Tannins	0-11	BCL2 like 1	Homo sapiens	182-188
29518944-8	2018	Tannic acid exhibited elevated G1 population, due to increase in p18INK4C and p21WAF1/CIP1 expression, while cyclin D1 expression was inhibited.	Tannins	0-11	cyclin dependent kinase inhibitor 2C	Homo sapiens	65-73
29518944-8	2018	Tannic acid exhibited elevated G1 population, due to increase in p18INK4C and p21WAF1/CIP1 expression, while cyclin D1 expression was inhibited.	Tannins	0-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-90
28771711-0	2018	Tannic acid attenuates TGF-beta1-induced epithelial-to-mesenchymal transition by effectively intervening TGF-beta signaling in lung epithelial cells.	Tannins	0-11	transforming growth factor beta 1	Homo sapiens	23-32
28771711-0	2018	Tannic acid attenuates TGF-beta1-induced epithelial-to-mesenchymal transition by effectively intervening TGF-beta signaling in lung epithelial cells.	Tannins	0-11	transforming growth factor beta 1	Homo sapiens	23-31
29594686-1	2018	The authors show that copper nanoclusters capped with tannic acid (TA-CuNCs) are viable fluorescent probes for the determination of the activity of pyrophosphatase (PPase).	Tannins	54-65	inorganic pyrophosphatase 1	Homo sapiens	148-163
29594686-1	2018	The authors show that copper nanoclusters capped with tannic acid (TA-CuNCs) are viable fluorescent probes for the determination of the activity of pyrophosphatase (PPase).	Tannins	54-65	inorganic pyrophosphatase 1	Homo sapiens	165-170
29258803-2	2018	In this work, catalase loaded polymer capsules functionalized with an external layer of tannic acid (TA) are fabricated via a layer-by-layer approach using calcium carbonate as a sacrificial template.	Tannins	88-99	catalase	Homo sapiens	14-22
29258803-2	2018	In this work, catalase loaded polymer capsules functionalized with an external layer of tannic acid (TA) are fabricated via a layer-by-layer approach using calcium carbonate as a sacrificial template.	Tannins	101-103	catalase	Homo sapiens	14-22
29258803-10	2018	Herein, polymer capsules loaded with catalase and functionalized with an external layer of tannic acid are fabricated, which can efficiently scavenge important reactive oxygen species (i.e., hydroxyl radicals and hydrogen peroxide) and modulate extracellular matrix activity in an in vitro inflammation model of nucleus pulposus.	Tannins	91-102	catalase	Homo sapiens	37-45
28877394-0	2018	HER2+ breast cancer cells undergo apoptosis upon exposure to tannic acid released from remodeled cross-linked collagen type I.	Tannins	61-72	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
29335826-0	2018	High-salt- and cholesterol diet-associated cognitive impairment attenuated by tannins-enriched fraction of Emblica officinalis via inhibiting NF-kB pathway.	Tannins	78-85	nuclear factor kappa B subunit 1	Rattus norvegicus	142-147
29085768-4	2017	Meanwhile, the metabolites of hydrolyzable tannins, such as urolithin A and gallic acid, exhibited H-bonding interactions with different residues of Abeta1-42, including Asp1, Asp23 and hydrophobic interactions by gallic acid planar ring to the Hsd6 residue.	Tannins	43-50	beta-secretase 2	Homo sapiens	170-174
30040534-5	2018	After optimization using the temperature and tannic acid concentration as variables with the Central Compound Rotational Design (CCRD), the maximal tannase production (25.6 U mL-1) was obtained at 29.8  C and 12.7%, respectively, which represents an increase of 2.56 times in relation to the initial activity.	Tannins	45-56	L1 cell adhesion molecule	Mus musculus	175-179
30040534-6	2018	The parameters optimized for the maximum production of gallic acid (21.51 mg mL-1) were 30  C and 10% tannic acid.	Tannins	102-113	L1 cell adhesion molecule	Mus musculus	77-81
29261112-4	2017	The results showed that optimum conditions were at 31  C and pH of 5, with a 50-h incubation period and 0.1 g L-1 of TA as substrate.	Tannins	117-119	L1 cell adhesion molecule	Mus musculus	110-113
33445373-5	2017	Subsequently, the obtained TA/PSBMA film was further chelated with CoII for specific binding to a His-tagged protein.	Tannins	27-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-71
28958718-0	2017	Galloyl groups-regulated fibrinogen conformation: Understanding antiplatelet adhesion on tannic acid coating.	Tannins	89-100	fibrinogen beta chain	Homo sapiens	25-35
28958718-10	2017	In this study, we demonstrated for the first time that tannic acid surface with abundant galloyl groups could induce minimal conformational changes of fibrinogen, eventually leading to an outstanding antiplatelet adhesion effect.	Tannins	55-66	fibrinogen beta chain	Homo sapiens	151-161
29195940-0	2017	Formation of complexes between tannic acid with bovine serum albumin, egg ovalbumin and bovine beta-lactoglobulin.	Tannins	31-42	ovalbumin	Bos taurus	74-83
29195940-0	2017	Formation of complexes between tannic acid with bovine serum albumin, egg ovalbumin and bovine beta-lactoglobulin.	Tannins	31-42	beta-lactoglobulin	Bos taurus	95-113
29195940-4	2017	BLG showed the highest binding affinity and a smallest binding distance with TA which may suggest that BLG-TA is the most stable complex.	Tannins	77-79	beta-lactoglobulin	Bos taurus	0-3
29195940-4	2017	BLG showed the highest binding affinity and a smallest binding distance with TA which may suggest that BLG-TA is the most stable complex.	Tannins	77-79	beta-lactoglobulin	Bos taurus	103-106
28922632-3	2017	In order to inhibit bacterial adhesion and activity in a long term, a salivary acquired pellicle (SAP) bioinspired tannic acid (SAP3-TA) is synthesized and characterized.	Tannins	115-126	ganglioside GM2 activator	Homo sapiens	128-132
29085768-4	2017	Meanwhile, the metabolites of hydrolyzable tannins, such as urolithin A and gallic acid, exhibited H-bonding interactions with different residues of Abeta1-42, including Asp1, Asp23 and hydrophobic interactions by gallic acid planar ring to the Hsd6 residue.	Tannins	43-50	RNA, U1 small nuclear 4	Homo sapiens	245-249
28345222-0	2017	Zein films with unoxidized or oxidized tannic acid.	Tannins	39-50	zein	Zea mays	0-4
29103458-3	2017	Our results demonstrated that pomegranate leaf and its main active ingredients (i.e., ellagic acid, gallic acid, pyrogallic acid and tannic acid) were capable of inhibiting pancreatic lipase activity in vitro.	Tannins	133-144	lipase, endothelial	Mus musculus	184-190
28345222-2	2017	Tannic acid, especially in its oxidized form, is supposed to cross-link proteins including zein, which may be explored to further enhance the water resistance of zein films.	Tannins	0-11	zein	Zea mays	91-95
28345222-2	2017	Tannic acid, especially in its oxidized form, is supposed to cross-link proteins including zein, which may be explored to further enhance the water resistance of zein films.	Tannins	0-11	zein	Zea mays	162-166
28345222-3	2017	The effects of different contents (0-8 wt%) of unoxidized and oxidized tannic acid (uTA and oTA, respectively) on the properties of zein films at different pH values (4-9) were studied, according to central composite designs.	Tannins	71-82	zein	Zea mays	132-136
28852023-1	2017	Novel soybean meal-based biomimetic (STP) adhesives were fabricated via soybean meal (SM) and enhanced by tannic acid (TA) and polyetheylenimine (PEI) (TAPI) co-crosslinking network based on natural polyphenol-inspired chemistry.	Tannins	106-117	sorbitol-like transporter	Glycine max	37-40
28631819-8	2017	The cardioprotective effects of TA may be attributed to multitargeted inhibition of oxidative stress, inflammation, fibrosis and apoptosis in addition to an increase in NO levels, decrease in ET-1 levels, and downregulation of angiotensin receptors and the phosphorylation of ERK1/2.	Tannins	32-34	mitogen activated protein kinase 3	Rattus norvegicus	276-282
28852023-1	2017	Novel soybean meal-based biomimetic (STP) adhesives were fabricated via soybean meal (SM) and enhanced by tannic acid (TA) and polyetheylenimine (PEI) (TAPI) co-crosslinking network based on natural polyphenol-inspired chemistry.	Tannins	119-121	sorbitol-like transporter	Glycine max	37-40
28751752-0	2017	Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells.	Tannins	0-11	Kruppel-like factor 2 (lung)	Mus musculus	78-82
28751752-4	2017	Using high-throughput luciferase reporter assay to screen for KLF2 activators, we have identified tannic acid (TA), a polyphenolic compound, as a potent KLF2 activator that attenuates endothelial inflammation.	Tannins	98-109	Kruppel-like factor 2 (lung)	Mus musculus	62-66
28751752-4	2017	Using high-throughput luciferase reporter assay to screen for KLF2 activators, we have identified tannic acid (TA), a polyphenolic compound, as a potent KLF2 activator that attenuates endothelial inflammation.	Tannins	98-109	Kruppel-like factor 2 (lung)	Mus musculus	153-157
28751752-4	2017	Using high-throughput luciferase reporter assay to screen for KLF2 activators, we have identified tannic acid (TA), a polyphenolic compound, as a potent KLF2 activator that attenuates endothelial inflammation.	Tannins	111-113	Kruppel-like factor 2 (lung)	Mus musculus	62-66
28751752-4	2017	Using high-throughput luciferase reporter assay to screen for KLF2 activators, we have identified tannic acid (TA), a polyphenolic compound, as a potent KLF2 activator that attenuates endothelial inflammation.	Tannins	111-113	Kruppel-like factor 2 (lung)	Mus musculus	153-157
33465868-9	2016	The mucoadhesion originated from intermolecular interaction between the polyphenols of TA and mucin, exhibiting pH dependency.	Tannins	87-89	LOC100508689	Homo sapiens	94-99
28368593-0	2017	Tannins and Tannin-Related Derivatives Enhance the (Pseudo-)Halogenating Activity of Lactoperoxidase.	Tannins	0-7	lactoperoxidase	Homo sapiens	85-100
28368593-0	2017	Tannins and Tannin-Related Derivatives Enhance the (Pseudo-)Halogenating Activity of Lactoperoxidase.	Tannins	0-6	lactoperoxidase	Homo sapiens	85-100
28368593-2	2017	Measurements were performed using 5-thio-2-nitrobenzoic acid in the presence of tannins and related substances in order to determine kinetic parameters and to trace the LPO-mediated -OSCN formation.	Tannins	80-87	lactoperoxidase	Homo sapiens	169-172
28368593-4	2017	The -OSCN-regenerating effect of tannin derivatives relates well with their binding properties toward LPO as well as their occupied molecular orbitals.	Tannins	33-39	lactoperoxidase	Homo sapiens	102-105
28368593-6	2017	As the (pseudo-)halogenating activity of LPO contributes to the maintenance of oral bacterial homeostasis, the results provide new insights into the antibacterial mode of action of tannins and related compounds.	Tannins	181-188	lactoperoxidase	Homo sapiens	41-44
28231749-0	2017	Flavonoids and Tannins from Smilax china L. Rhizome Induce Apoptosis Via Mitochondrial Pathway and MDM2-p53 Signaling in Human Lung Adenocarcinoma Cells.	Tannins	15-22	MDM2 proto-oncogene	Homo sapiens	99-103
28231749-0	2017	Flavonoids and Tannins from Smilax china L. Rhizome Induce Apoptosis Via Mitochondrial Pathway and MDM2-p53 Signaling in Human Lung Adenocarcinoma Cells.	Tannins	15-22	tumor protein p53	Homo sapiens	104-107
28231749-9	2017	Finally, cleaved-caspase-3 protein levels in the total flavonoids or total tannins-treated H1299 (p53 null) and p53-knockdown A549 cells were increased.	Tannins	75-82	tumor protein p53	Homo sapiens	98-101
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Tannins	32-43	cystathionine beta-synthase	Homo sapiens	107-110
26560070-13	2016	CONCLUSION: Comprehensive genetic analyses and collagen or tannic acid staining may be useful for diagnosis of LMX1B-associated nephropathy.	Tannins	59-70	LIM homeobox transcription factor 1 beta	Homo sapiens	111-116
28769992-13	2017	With tannin consumption, PRP production is increased, and may be an initial line of defense against tannin-non-heme iron chelation in vivo.	Tannins	5-11	prion protein	Homo sapiens	25-28
28769992-13	2017	With tannin consumption, PRP production is increased, and may be an initial line of defense against tannin-non-heme iron chelation in vivo.	Tannins	100-106	prion protein	Homo sapiens	25-28
28334479-3	2017	The selective adsorption of tannic acids (TAs) on MSN silica walls opens the MSN mesoporous channels without disturbing mass transport.	Tannins	28-40	moesin	Equus caballus	50-53
28334479-3	2017	The selective adsorption of tannic acids (TAs) on MSN silica walls opens the MSN mesoporous channels without disturbing mass transport.	Tannins	28-40	moesin	Equus caballus	77-80
28334479-3	2017	The selective adsorption of tannic acids (TAs) on MSN silica walls opens the MSN mesoporous channels without disturbing mass transport.	Tannins	42-45	moesin	Equus caballus	50-53
28334479-3	2017	The selective adsorption of tannic acids (TAs) on MSN silica walls opens the MSN mesoporous channels without disturbing mass transport.	Tannins	42-45	moesin	Equus caballus	77-80
27862996-0	2017	Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.	Tannins	0-11	epidermal growth factor receptor	Homo sapiens	21-25
27862996-0	2017	Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.	Tannins	0-11	signal transducer and activator of transcription 1	Homo sapiens	26-33
27862996-0	2017	Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.	Tannins	0-11	mitogen-activated protein kinase 14	Homo sapiens	47-50
27862996-0	2017	Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.	Tannins	0-11	signal transducer and activator of transcription 1	Homo sapiens	26-31
27862996-6	2017	Tannic acid enhanced STAT1 ser727 phosphorylation via upstream serine kinase p38.	Tannins	0-11	signal transducer and activator of transcription 1	Homo sapiens	21-26
27862996-6	2017	Tannic acid enhanced STAT1 ser727 phosphorylation via upstream serine kinase p38.	Tannins	0-11	mitogen-activated protein kinase 14	Homo sapiens	77-80
28281573-0	2017	Formulation for Oral Delivery of Lactoferrin Based on Bovine Serum Albumin and Tannic Acid Multilayer Microcapsules.	Tannins	79-90	lactotransferrin	Mus musculus	33-44
28281573-3	2017	The shells comprising alternate layers of bovine serum albumin (BSA) and tannic acid (TA) were tested as Lf encapsulation system for oral administration.	Tannins	86-88	lactotransferrin	Mus musculus	105-107
27165705-0	2017	Interactions of hybrid gold-tannic acid nanoparticles with human serum albumin.	Tannins	28-39	albumin	Homo sapiens	65-78
27165705-4	2017	The synthesized hybrid gold-tannic acid nanoparticles strongly interact with human serum albumin by formation of protein-corona complexes.	Tannins	28-39	albumin	Homo sapiens	83-96
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Tannins	33-44	cystathionine beta-synthase	Homo sapiens	117-120
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Tannins	33-44	cystathionine beta-synthase	Homo sapiens	213-216
27216470-6	2016	Tannic acid-modified but not unmodified AgNPs down-regulated TNF-alpha and LPS-triggered production of IL-8 in VK2-E6/E7 but not in HaCaT cells.	Tannins	0-11	tumor necrosis factor	Homo sapiens	61-70
27216470-6	2016	Tannic acid-modified but not unmodified AgNPs down-regulated TNF-alpha and LPS-triggered production of IL-8 in VK2-E6/E7 but not in HaCaT cells.	Tannins	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	103-107
27481714-10	2016	Membrane potential measurements reveal an interplay between La(3+)-sensitive ion channels and those that are sensitive to the specific TMEM16A inhibitor tannic acid.	Tannins	153-164	anoctamin 1	Rattus norvegicus	135-142
27060814-12	2016	Results of this study indicated beneficial effects of 0.45% tannin extract in the diet on milk protein content.	Tannins	60-66	casein beta	Bos taurus	90-102
26810570-3	2016	Pre-treatment of mice with TA (25 or 50 g/kg/day) significantly ameliorated hepatic morphology and coefficient values and reduced the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the concentrations of malondialdehyde (MDA) and serum levels of endothelin-1 (ET-1).	Tannins	27-29	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	148-174
26810570-6	2016	Furthermore, TA (0.01 muM, 0.1 muM or 1 muM) decreased the TIMP-1/MMP-1 ratio and reduced the viability of HSCs.	Tannins	13-15	matrix metallopeptidase 13	Mus musculus	66-71
26969140-0	2016	Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries.	Tannins	0-11	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	26-31
26969140-0	2016	Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries.	Tannins	0-11	potassium voltage-gated channel subfamily Q member 3	Homo sapiens	36-41
26969140-1	2016	OBJECTIVES: This study investigated the effect of tannic acid (TA), a plant-derived hydrolyzable polyphenol, on Kv7.4 and Kv7.5 K(+) channels and rat mesenteric artery.	Tannins	50-61	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	112-117
26969140-1	2016	OBJECTIVES: This study investigated the effect of tannic acid (TA), a plant-derived hydrolyzable polyphenol, on Kv7.4 and Kv7.5 K(+) channels and rat mesenteric artery.	Tannins	63-65	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	112-117
26969140-3	2016	KEY FINDINGS: Tannic acid increases the Kv7.4 and Kv7.3/7.5 K(+) currents in a concentration-dependent manner (median effective concentration (EC50 ) = 27.3 +- 3.6 mum and EC50 = 23.1 +- 3.9 mum, respectively).	Tannins	14-25	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	40-45
26969140-3	2016	KEY FINDINGS: Tannic acid increases the Kv7.4 and Kv7.3/7.5 K(+) currents in a concentration-dependent manner (median effective concentration (EC50 ) = 27.3 +- 3.6 mum and EC50 = 23.1 +- 3.9 mum, respectively).	Tannins	14-25	potassium voltage-gated channel subfamily Q member 3	Homo sapiens	50-55
26582426-7	2016	These currents are nearly abolished by blocking Ano1 antibodies or by the inhibitors 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide (T-AO1) and tannic acid (TA).	Tannins	191-202	anoctamin 1, calcium activated chloride channel	Mus musculus	48-52
26582426-7	2016	These currents are nearly abolished by blocking Ano1 antibodies or by the inhibitors 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide (T-AO1) and tannic acid (TA).	Tannins	204-206	anoctamin 1, calcium activated chloride channel	Mus musculus	48-52
26349913-0	2016	Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells.	Tannins	20-31	fatty acid synthase	Homo sapiens	35-54
26349913-5	2016	Our previous studies demonstrated that TA is a natural FAS inhibitor whose inhibitory activity is stronger than that of classical FAS inhibitors, such as C75 and cerulenin.	Tannins	39-41	fatty acid synthase	Homo sapiens	55-58
26349913-7	2016	Since high-expressed FAS is recognized as a molecular marker for breast cancer and plays an important role in cancer prognosis, these findings suggest that TA is a potential drug candidate for treatment of breast cancer.	Tannins	156-158	fatty acid synthase	Homo sapiens	21-24
26810570-3	2016	Pre-treatment of mice with TA (25 or 50 g/kg/day) significantly ameliorated hepatic morphology and coefficient values and reduced the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the concentrations of malondialdehyde (MDA) and serum levels of endothelin-1 (ET-1).	Tannins	27-29	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	176-179
26810570-3	2016	Pre-treatment of mice with TA (25 or 50 g/kg/day) significantly ameliorated hepatic morphology and coefficient values and reduced the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the concentrations of malondialdehyde (MDA) and serum levels of endothelin-1 (ET-1).	Tannins	27-29	glutamic pyruvic transaminase, soluble	Mus musculus	185-209
26810570-3	2016	Pre-treatment of mice with TA (25 or 50 g/kg/day) significantly ameliorated hepatic morphology and coefficient values and reduced the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the concentrations of malondialdehyde (MDA) and serum levels of endothelin-1 (ET-1).	Tannins	27-29	glutamic pyruvic transaminase, soluble	Mus musculus	211-214
26810570-3	2016	Pre-treatment of mice with TA (25 or 50 g/kg/day) significantly ameliorated hepatic morphology and coefficient values and reduced the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the concentrations of malondialdehyde (MDA) and serum levels of endothelin-1 (ET-1).	Tannins	27-29	endothelin 1	Mus musculus	281-293
26810570-6	2016	Furthermore, TA (0.01 muM, 0.1 muM or 1 muM) decreased the TIMP-1/MMP-1 ratio and reduced the viability of HSCs.	Tannins	13-15	tissue inhibitor of metalloproteinase 1	Mus musculus	59-65
26562188-0	2015	A facile and effective immobilization of glucose oxidase on tannic acid modified CoFe2O4 magnetic nanoparticles.	Tannins	60-71	hydroxyacid oxidase 1	Homo sapiens	41-56
26562188-2	2015	By using the strong protein and tannic acid binding, GOx immobilization was carried out via physical adsorption in a simpler way compared with the other immobilization methods which require various chemicals and complicated procedures which is difficult, expensive, time-consuming, and destructive to the enzyme structure.	Tannins	32-43	hydroxyacid oxidase 1	Homo sapiens	53-56
26049169-0	2015	Tannic acid modulates NFkappaB signaling pathway and skin inflammation in NC/Nga mice through PPARgamma expression.	Tannins	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-30
26562188-1	2015	This article presents a study of glucose oxidase (GOx) immobilization by employing tannic acid (TA) modified-CoFe2O4 (CFO) magnetic nanoparticles which demonstrates novel aspect for enzyme immobilization.	Tannins	83-94	hydroxyacid oxidase 1	Homo sapiens	33-48
26562188-1	2015	This article presents a study of glucose oxidase (GOx) immobilization by employing tannic acid (TA) modified-CoFe2O4 (CFO) magnetic nanoparticles which demonstrates novel aspect for enzyme immobilization.	Tannins	83-94	hydroxyacid oxidase 1	Homo sapiens	50-53
26562188-1	2015	This article presents a study of glucose oxidase (GOx) immobilization by employing tannic acid (TA) modified-CoFe2O4 (CFO) magnetic nanoparticles which demonstrates novel aspect for enzyme immobilization.	Tannins	96-98	hydroxyacid oxidase 1	Homo sapiens	33-48
26562188-1	2015	This article presents a study of glucose oxidase (GOx) immobilization by employing tannic acid (TA) modified-CoFe2O4 (CFO) magnetic nanoparticles which demonstrates novel aspect for enzyme immobilization.	Tannins	96-98	hydroxyacid oxidase 1	Homo sapiens	50-53
26625122-0	2015	Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells.	Tannins	11-22	ETS transcription factor ERG	Homo sapiens	50-54
26049169-0	2015	Tannic acid modulates NFkappaB signaling pathway and skin inflammation in NC/Nga mice through PPARgamma expression.	Tannins	0-11	peroxisome proliferator activated receptor gamma	Mus musculus	94-103
26049169-6	2015	Serum levels of IFNgamma and IL-4 were significantly down-regulated by tannic acid.	Tannins	71-82	interferon gamma	Mus musculus	16-24
26049169-6	2015	Serum levels of IFNgamma and IL-4 were significantly down-regulated by tannic acid.	Tannins	71-82	interleukin 4	Mus musculus	29-33
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	tumor necrosis factor	Mus musculus	80-89
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	advanced glycosylation end product-specific receptor	Mus musculus	128-172
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	advanced glycosylation end product-specific receptor	Mus musculus	174-178
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	mitogen-activated protein kinase 3	Mus musculus	181-227
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	229-237
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	cytochrome c oxidase II, mitochondrial	Mus musculus	255-260
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	interleukin 1 beta	Mus musculus	262-270
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	peroxisome proliferator activated receptor gamma	Mus musculus	355-365
26049169-8	2015	Taken together, our results demonstrate that, DfE induced skin inflammation might be mediated through NFkappaB signaling and tannic acid may be a potential therapeutic agent for AD, which may possibly act via induction of PPARgamma protein.	Tannins	125-136	peroxisome proliferator activated receptor gamma	Mus musculus	222-231
26625122-3	2015	The present study investigated the effects of tannic acid, green teas and red wines on hERG currents.	Tannins	46-57	ETS transcription factor ERG	Homo sapiens	87-91
26625122-5	2015	In this study, we demonstrated that tannic acid inhibited hERG currents with an IC50 of 3.4 muM and ~100% inhibition at higher concentrations, and significantly shifted the voltage dependent activation to more positive potentials (Delta23.2 mV).	Tannins	36-47	ETS transcription factor ERG	Homo sapiens	58-62
26625122-8	2015	The effects of tannic acid, teas and red wine on hERG currents were irreversible.	Tannins	15-26	ETS transcription factor ERG	Homo sapiens	49-53
26625122-9	2015	These results suggest tannic acid is a novel hERG channel blocker and consequently provide a new mechanistic evidence for understanding the effects of tannic acid.	Tannins	22-33	ETS transcription factor ERG	Homo sapiens	45-49
25989747-7	2015	Moreover, TA pretreatment contributed to the decrease in ratio of Bax/Bcl-2, as well as reduced expression of TNF-alpha, IL-1beta, caspase-3, cleaved-caspase-3 and -9.	Tannins	10-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	66-69
26351757-8	2015	Although mouse TRPA1 was inhibited by tannic acid, pfTRPA1 channels were enhanced by the treatment with tannic acid.	Tannins	38-49	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	15-20
26134502-7	2015	We demonstrated that tannic acid enhanced M/Kv7 K(+) currents but inhibited bradykinin-induced activation of CaCC/TMEM16A currents in rat small DRG neurons.	Tannins	21-32	anoctamin 1	Rattus norvegicus	114-121
26134502-8	2015	Tannic acid potentiated Kv7.2/7.3 and Kv7.2 currents expressed in HEK293B cells, with an EC50 of 7.38 and 5.40 microM, respectively.	Tannins	0-11	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	24-29
26134502-8	2015	Tannic acid potentiated Kv7.2/7.3 and Kv7.2 currents expressed in HEK293B cells, with an EC50 of 7.38 and 5.40 microM, respectively.	Tannins	0-11	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	38-43
26134502-12	2015	This study thus demonstrates that tannic acid is an activator of M/Kv7 K(+) and an inhibitor of voltage-gated Na(+) channels and CaCC/TMEM16A, which may underlie its inhibitory effects on excitability of DRG neurons and its analgesic effect.	Tannins	34-45	anoctamin 1	Rattus norvegicus	134-141
26202061-0	2015	Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells.	Tannins	0-11	Janus kinase 2	Homo sapiens	25-29
26202061-0	2015	Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells.	Tannins	0-11	signal transducer and activator of transcription 3	Homo sapiens	30-35
26202061-8	2015	Additionally, upon treatment with TA, the expression of mitochondrial pore factors Bax, Bcl-2 and Bcl-XL were changed.	Tannins	34-36	BCL2 associated X, apoptosis regulator	Homo sapiens	83-86
26202061-8	2015	Additionally, upon treatment with TA, the expression of mitochondrial pore factors Bax, Bcl-2 and Bcl-XL were changed.	Tannins	34-36	BCL2 apoptosis regulator	Homo sapiens	88-93
26202061-8	2015	Additionally, upon treatment with TA, the expression of mitochondrial pore factors Bax, Bcl-2 and Bcl-XL were changed.	Tannins	34-36	BCL2 like 1	Homo sapiens	98-104
26202061-12	2015	Taken together, this study reveals that TA significantly inhibits the Jak2/STAT3 signaling pathway and induces G1 arrest and mitochondrial apoptosis in YD-38 cells.	Tannins	40-42	Janus kinase 2	Homo sapiens	70-74
26202061-12	2015	Taken together, this study reveals that TA significantly inhibits the Jak2/STAT3 signaling pathway and induces G1 arrest and mitochondrial apoptosis in YD-38 cells.	Tannins	40-42	signal transducer and activator of transcription 3	Homo sapiens	75-80
25989747-7	2015	Moreover, TA pretreatment contributed to the decrease in ratio of Bax/Bcl-2, as well as reduced expression of TNF-alpha, IL-1beta, caspase-3, cleaved-caspase-3 and -9.	Tannins	10-12	BCL2, apoptosis regulator	Rattus norvegicus	70-75
25989747-7	2015	Moreover, TA pretreatment contributed to the decrease in ratio of Bax/Bcl-2, as well as reduced expression of TNF-alpha, IL-1beta, caspase-3, cleaved-caspase-3 and -9.	Tannins	10-12	tumor necrosis factor	Rattus norvegicus	110-119
25989747-7	2015	Moreover, TA pretreatment contributed to the decrease in ratio of Bax/Bcl-2, as well as reduced expression of TNF-alpha, IL-1beta, caspase-3, cleaved-caspase-3 and -9.	Tannins	10-12	interleukin 1 beta	Rattus norvegicus	121-129
25989747-7	2015	Moreover, TA pretreatment contributed to the decrease in ratio of Bax/Bcl-2, as well as reduced expression of TNF-alpha, IL-1beta, caspase-3, cleaved-caspase-3 and -9.	Tannins	10-12	caspase 3	Rattus norvegicus	131-140
25989747-7	2015	Moreover, TA pretreatment contributed to the decrease in ratio of Bax/Bcl-2, as well as reduced expression of TNF-alpha, IL-1beta, caspase-3, cleaved-caspase-3 and -9.	Tannins	10-12	caspase 3	Rattus norvegicus	150-159
25520592-2	2014	Herein we report a systematic investigation of the impacts of gold nanoparticles (AuNPs) on five major CYP isozymes under in vitro incubations of human liver microsomes (HLMs) with tannic acid (TA)-stabilized AuNPs in the size range of 5 to 100 nm.	Tannins	181-192	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	103-106
26186636-0	2015	Tannic Acid Inhibits Hepatitis C Virus Entry into Huh7.5 Cells.	Tannins	0-11	MIR7-3 host gene	Homo sapiens	50-54
26186636-7	2015	In this study, we demonstrate that tannic acid is a potent inhibitor of HCV entry into Huh7.5 cells at low concentrations (IC50 5.8 muM).	Tannins	35-46	MIR7-3 host gene	Homo sapiens	87-91
26186636-7	2015	In this study, we demonstrate that tannic acid is a potent inhibitor of HCV entry into Huh7.5 cells at low concentrations (IC50 5.8 muM).	Tannins	35-46	latexin	Homo sapiens	132-135
25623997-0	2015	Inhibitory effects of tannic acid in the early stage of 3T3-L1 preadipocytes differentiation by down-regulating PPARgamma expression.	Tannins	22-33	peroxisome proliferator activated receptor gamma	Homo sapiens	112-121
25697604-7	2015	Biochemical evaluation of brain tissue found that comparing the ischemic group with no treatment with the tannic acid-treated ischemia group; the superoxide dismutase (SOD) levels were higher, malondialdehyde (MDA) levels were lower, and nuclear respiratory factor-1 (NRF-1) was higher in the tannic acid-treated group.	Tannins	106-117	nuclear respiratory factor 1	Rattus norvegicus	238-266
25697604-7	2015	Biochemical evaluation of brain tissue found that comparing the ischemic group with no treatment with the tannic acid-treated ischemia group; the superoxide dismutase (SOD) levels were higher, malondialdehyde (MDA) levels were lower, and nuclear respiratory factor-1 (NRF-1) was higher in the tannic acid-treated group.	Tannins	106-117	nuclear respiratory factor 1	Rattus norvegicus	268-273
26013280-0	2015	Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer"s Amyloid beta-Peptide Aggregation.	Tannins	17-28	amyloid beta precursor protein	Homo sapiens	103-115
25800511-5	2015	On the other hand, protocatechuic and tannic acids enhanced only the expression of GSTA, GSTM, and GSTT.	Tannins	38-50	glutathione S-transferase mu 2	Homo sapiens	89-93
25800511-7	2015	These results indicate that isothiocyanates/indoles and protocatechuic and tannic acids induce phase II and antioxidant gene expression in HepG2 cells through the Nrf2-Keap1-ARE signaling pathway.	Tannins	75-87	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
25800511-7	2015	These results indicate that isothiocyanates/indoles and protocatechuic and tannic acids induce phase II and antioxidant gene expression in HepG2 cells through the Nrf2-Keap1-ARE signaling pathway.	Tannins	75-87	kelch like ECH associated protein 1	Homo sapiens	168-173
25603235-6	2015	Erythrosine sodium, suramin, tannic acid and sanguinarine sulfate were characterized with IC50 values of 0.2, 0.3, 0.4, and 0.6 muM, respectively.	Tannins	29-40	latexin	Homo sapiens	128-131
25399297-7	2015	TA prevents the DMBA + croton oil-induced toxicity through a protective mechanism that involves the reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression and level of proinflammatory cytokine such as IL-6 release at a very significant level (p &lt; 0.001).	Tannins	0-2	cytochrome c oxidase II, mitochondrial	Mus musculus	141-146
25399297-7	2015	TA prevents the DMBA + croton oil-induced toxicity through a protective mechanism that involves the reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression and level of proinflammatory cytokine such as IL-6 release at a very significant level (p &lt; 0.001).	Tannins	0-2	nitric oxide synthase 2, inducible	Mus musculus	148-153
25399297-7	2015	TA prevents the DMBA + croton oil-induced toxicity through a protective mechanism that involves the reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression and level of proinflammatory cytokine such as IL-6 release at a very significant level (p &lt; 0.001).	Tannins	0-2	proliferating cell nuclear antigen	Mus musculus	155-159
25399297-7	2015	TA prevents the DMBA + croton oil-induced toxicity through a protective mechanism that involves the reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression and level of proinflammatory cytokine such as IL-6 release at a very significant level (p &lt; 0.001).	Tannins	0-2	interleukin 6	Mus musculus	225-229
25313718-0	2014	Counteracting suppression of CFTR and voltage-gated K+ channels by a bacterial pathogenic factor with the natural product tannic acid.	Tannins	122-133	CF transmembrane conductance regulator	Homo sapiens	29-33
23241588-6	2013	Finally, the inhibition of the proteasome by a combination of quercetin plus tannic acid in Hep-2 cells resulted in the induction of S5a at low dose, accumulation of ubiquitin, and the cleavage of pro-caspase-3, followed by the induction of apoptotic cell death.	Tannins	77-88	caspase 3	Homo sapiens	197-210
24152967-7	2014	Moreover, two inhibitors of anoctamin ion channels, tannic acid and a more selective inhibitor of anoctamin 1, significantly inhibited PLC cyst growth and cyst enlargement in an embryonic kidney cyst model.	Tannins	52-63	heparan sulfate proteoglycan 2	Homo sapiens	135-138
24531910-6	2014	Iron uptake decreased in cells cultured with tannic acid (300 muM) and CaCl2 (500-1,000 muM) (two-way ANOVA, p = 0.002).	Tannins	45-56	latexin	Homo sapiens	62-65
24380573-4	2014	Tannic acid decreased also the c-Jun AP-1 subunit level and binding to TPA response element (TRE) (3- and 2-fold in comparison with TPA-treated group respectively).	Tannins	0-11	jun proto-oncogene	Mus musculus	37-41
24251093-0	2013	Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting e germline transcription induced by STAT6 activation.	Tannins	0-11	signal transducer and activator of transcription 6	Homo sapiens	148-153
24251093-4	2013	Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin-induced IgE production in vivo by inhibiting IL-4-induced eGT expression and the IL-4 signaling pathway.	Tannins	13-24	interleukin 4	Homo sapiens	118-122
24251093-4	2013	Furthermore, tannic acid, a higher galloylated PGG, attenuated ovalbumin-induced IgE production in vivo by inhibiting IL-4-induced eGT expression and the IL-4 signaling pathway.	Tannins	13-24	interleukin 4	Homo sapiens	154-158
24251093-5	2013	In conclusion, our results suggest that tannic acid may attenuate allergic diseases by suppressing IgE production by inhibiting IL-4-induced signaling.	Tannins	40-51	interleukin 4	Homo sapiens	128-132
23474323-6	2013	Processing flour into PRMP led to a significant (p&lt;0.05) reduction of tannins (50%), total polyphenols (50%) and trypsin inhibitors (94%).	Tannins	73-80	shisa family member 4	Rattus norvegicus	22-26
25693384-8	2014	Meanwhile, the large molecular of tannic acid is also easier to be adsorbed by the hydrolysis products of PAC1.	Tannins	34-45	dual specificity phosphatase 2	Homo sapiens	106-110
24498245-6	2014	We observed interesting mechanistic differences between tannin structures: High molecular weight tannin containing extracts and tannic acid (1702 g/mol) inhibited both IAV receptor binding and neuraminidase activity.	Tannins	128-139	neuraminidase 1	Homo sapiens	193-206
24444964-4	2014	Anthocyanin concentration might be a key component for increasing tannin solubility and extraction into wine and the formation of polymeric pigments.	Tannins	66-72	DDB1 and CUL4 associated factor 7	Homo sapiens	0-11
23997176-9	2013	Furthermore, two distinct TMEM16A antagonists (tannic acid and benzbromarone) impaired a substance P-induced contraction in isolated guinea pig tracheal rings.	Tannins	47-58	anoctamin 1	Homo sapiens	26-33
24046866-5	2013	In the meantime, tannic acid decreased the expression of FAS and down-regulated the mRNA level of FAS and PPARgamma during adipocyte differentiation.	Tannins	17-28	peroxisome proliferator activated receptor gamma	Homo sapiens	106-115
22011646-0	2012	Bovine AAV transcytosis inhibition by tannic acid results in functional expression of CFTR in vitro and altered biodistribution in vivo.	Tannins	38-49	CF transmembrane conductance regulator	Homo sapiens	86-90
23124075-2	2013	The cytochrome P4501A1 (CYP1A1) enzyme is central to the metabolic activation of these xenobiotics, whereas CYP2E1 metabolizes the nitrosamines and tannins.	Tannins	148-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	4-22
23124075-2	2013	The cytochrome P4501A1 (CYP1A1) enzyme is central to the metabolic activation of these xenobiotics, whereas CYP2E1 metabolizes the nitrosamines and tannins.	Tannins	148-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	24-30
23124075-2	2013	The cytochrome P4501A1 (CYP1A1) enzyme is central to the metabolic activation of these xenobiotics, whereas CYP2E1 metabolizes the nitrosamines and tannins.	Tannins	148-155	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	108-114
25683413-0	2012	Effect of tannic acid on properties of soybean (Glycine max) seed ferritin: a model for interaction between naturally-occurring components in foodstuffs.	Tannins	10-21	ferritin-1, chloroplastic	Glycine max	66-74
25683413-3	2012	In this study, we focus on the interaction between tannic acid (TA) and soybean seed ferritin (SSF), since they co-exist in many foodstuffs, and the consequence of this interaction.	Tannins	51-62	ferritin-1, chloroplastic	Glycine max	85-93
25683413-3	2012	In this study, we focus on the interaction between tannic acid (TA) and soybean seed ferritin (SSF), since they co-exist in many foodstuffs, and the consequence of this interaction.	Tannins	64-66	ferritin-1, chloroplastic	Glycine max	85-93
24217651-6	2013	RESULTS: A 48 h treatment with tannic acid was followed by significant decrease of forward scatter (&gt;= 1 microg/ml) and significant increase of annexin-V-binding (&gt;= 10 microg/ml).	Tannins	31-42	annexin A5	Homo sapiens	147-156
24217651-8	2013	The annexin-V-binding following tannic acid treatment (50 microM) was significantly blunted in the nominal absence of extracellular Ca(2+).	Tannins	32-43	annexin A5	Homo sapiens	4-13
24369505-6	2013	TA-induced apoptosis involved activation of caspase 3/7 and caspase 9 but not caspase 8.	Tannins	0-2	caspase 9	Homo sapiens	44-69
22785358-0	2012	Tannic acid, an inhibitor of poly(ADP-ribose) glycohydrolase, sensitizes ovarian carcinoma cells to cisplatin.	Tannins	0-11	poly(ADP-ribose) glycohydrolase	Homo sapiens	29-60
22957419-10	2012	LSE had significant higher total phenol (300.11 +/- 1.99), flavonoid (53.12 +/- 0.48) and tannin content (118.90 +/- 0.15) compared to ASE which possessed total phenol (159.93 +/- 0.87); flavonoid (9.37 +/- 0.73) and tannin content (80.5 +/- 0.19).	Tannins	90-96	low set ears	Mus musculus	0-3
22957419-10	2012	LSE had significant higher total phenol (300.11 +/- 1.99), flavonoid (53.12 +/- 0.48) and tannin content (118.90 +/- 0.15) compared to ASE which possessed total phenol (159.93 +/- 0.87); flavonoid (9.37 +/- 0.73) and tannin content (80.5 +/- 0.19).	Tannins	217-223	low set ears	Mus musculus	0-3
22555559-4	2012	PXN catalyzed fast counter-exchange of substrates and much slower uniport and was strongly inhibited by pyridoxal 5"-phosphate, bathophenanthroline and tannic acid.	Tannins	152-163	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-3
22169226-0	2012	Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells.	Tannins	0-11	complement factor B	Homo sapiens	72-91
22107990-12	2012	The phytochemical study of Ba-CAE showed the presence of flavones as luteolin and acacetin, caffeoylquinic acids as chlorogenic acid, and tannins.	Tannins	138-145	gap junction protein alpha 8	Homo sapiens	30-33
21724663-7	2012	Pretreatment of TA in mice showed significant (p &lt; 0.001) recovery in antioxidant status, viz., reduced glutathione content and its dependent enzymes, quinone reductase and gamma-glutamyl transpeptidase.	Tannins	16-18	crystallin, zeta	Mus musculus	154-171
22280815-4	2012	Our screen identified two compounds which specifically affect ATE1-regulated processes in vivo, including tannic acid, which has been previously shown to inhibit protein degradation and angiogenesis and to act as a therapeutic agent in heart disease and cancer.	Tannins	106-117	arginyltransferase 1	Homo sapiens	62-66
22280815-5	2012	Our data suggest that these actions of tannic acid are mediated by its direct effect on ATE1, which regulates protein degradation and angiogenesis in vivo.	Tannins	39-50	arginyltransferase 1	Homo sapiens	88-92
22322600-0	2012	Tannic acid down-regulates the angiotensin type 1 receptor through a MAPK-dependent mechanism.	Tannins	0-11	angiotensin II receptor, type 1a	Rattus norvegicus	31-58
22322600-0	2012	Tannic acid down-regulates the angiotensin type 1 receptor through a MAPK-dependent mechanism.	Tannins	0-11	mitogen activated protein kinase 3	Rattus norvegicus	69-73
22322600-1	2012	In the present study, we investigated the effects of tannic acid (TA), a hydrolysable polyphenol, on angiotensin type 1 receptor (AT1R) expression in continuously passaged rat liver epithelial cells.	Tannins	53-64	angiotensin II receptor, type 1a	Rattus norvegicus	101-128
22322600-1	2012	In the present study, we investigated the effects of tannic acid (TA), a hydrolysable polyphenol, on angiotensin type 1 receptor (AT1R) expression in continuously passaged rat liver epithelial cells.	Tannins	53-64	angiotensin II receptor, type 1a	Rattus norvegicus	130-134
22322600-1	2012	In the present study, we investigated the effects of tannic acid (TA), a hydrolysable polyphenol, on angiotensin type 1 receptor (AT1R) expression in continuously passaged rat liver epithelial cells.	Tannins	66-68	angiotensin II receptor, type 1a	Rattus norvegicus	101-128
22322600-1	2012	In the present study, we investigated the effects of tannic acid (TA), a hydrolysable polyphenol, on angiotensin type 1 receptor (AT1R) expression in continuously passaged rat liver epithelial cells.	Tannins	66-68	angiotensin II receptor, type 1a	Rattus norvegicus	130-134
22322600-4	2012	In TA-treated cells, we observed a significant reduction in AngII-mediated intracellular calcium signaling, a finding consistent with receptor down-regulation.	Tannins	3-5	angiotensinogen	Rattus norvegicus	60-65
22322600-10	2012	Our findings demonstrate, for the first time, that TA inhibits AT1R gene expression and cellular response, suggesting the observed protective effects of dietary polyphenols on cardiovascular conditions may be, in part, through inhibition of AT1R expression.	Tannins	51-53	angiotensin II receptor, type 1a	Rattus norvegicus	63-67
22322600-10	2012	Our findings demonstrate, for the first time, that TA inhibits AT1R gene expression and cellular response, suggesting the observed protective effects of dietary polyphenols on cardiovascular conditions may be, in part, through inhibition of AT1R expression.	Tannins	51-53	angiotensin II receptor, type 1a	Rattus norvegicus	241-245
22219198-7	2012	As in vitro validation, we treated well characterized mutant human APP-overexpressing murine neuron-like cells with TA and found significantly reduced Abeta production associated with less amyloidogenic APP proteolysis.	Tannins	116-118	amyloid beta (A4) precursor protein	Mus musculus	151-156
23167349-7	2012	TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-alpha(p&lt;0.001) release.	Tannins	0-2	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	146-151
23167349-7	2012	TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-alpha(p&lt;0.001) release.	Tannins	0-2	nitric oxide synthase 2	Rattus norvegicus	153-158
23167349-7	2012	TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-alpha(p&lt;0.001) release.	Tannins	0-2	proliferating cell nuclear antigen	Rattus norvegicus	160-164
23167349-7	2012	TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-alpha(p&lt;0.001) release.	Tannins	0-2	tumor necrosis factor	Rattus norvegicus	195-204
21748285-7	2012	The treatment of HT29-CL19A cells with clinically relevant concentrations of tannic acid (0.01-1 mg/ml) significantly increased transepithelial resistance (TER) and inhibited the cystic fibrosis transmembrane conductance regulator (CFTR)-dependent or the calcium-activated Cl(-) secretion.	Tannins	77-88	CF transmembrane conductance regulator	Homo sapiens	179-230
21748285-7	2012	The treatment of HT29-CL19A cells with clinically relevant concentrations of tannic acid (0.01-1 mg/ml) significantly increased transepithelial resistance (TER) and inhibited the cystic fibrosis transmembrane conductance regulator (CFTR)-dependent or the calcium-activated Cl(-) secretion.	Tannins	77-88	CF transmembrane conductance regulator	Homo sapiens	232-236
21748285-8	2012	Tannic acid could also improve the impaired epithelial barrier function induced by tumor necrosis factor alpha (TNFalpha) and inhibited the disrupting effect of TNFalpha on the epithelial barrier function in these cells.	Tannins	0-11	tumor necrosis factor	Homo sapiens	83-110
21748285-8	2012	Tannic acid could also improve the impaired epithelial barrier function induced by tumor necrosis factor alpha (TNFalpha) and inhibited the disrupting effect of TNFalpha on the epithelial barrier function in these cells.	Tannins	0-11	tumor necrosis factor	Homo sapiens	112-120
21748285-8	2012	Tannic acid could also improve the impaired epithelial barrier function induced by tumor necrosis factor alpha (TNFalpha) and inhibited the disrupting effect of TNFalpha on the epithelial barrier function in these cells.	Tannins	0-11	tumor necrosis factor	Homo sapiens	161-169
21503579-8	2011	Moreover, tannic acid attenuated COX-2 mRNA induced by HY(-) extract in a dose-dependent manner.	Tannins	10-21	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	33-38
21736774-0	2011	Tannic acid is more effective than clofibrate for the elevation of hepatic beta-oxidation and the inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and aortic lesion formation in apo E-deficient mice.	Tannins	0-11	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	112-153
21736774-3	2011	Both TA and CF supplementation lowered hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) activity and prevented atherosclerotic lesion formation in comparison with the control group.	Tannins	5-7	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	47-88
21736774-3	2011	Both TA and CF supplementation lowered hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) activity and prevented atherosclerotic lesion formation in comparison with the control group.	Tannins	5-7	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	90-94
21387315-1	2011	Tannic acid (TA) inhibits nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P450 reductase (CPR) activity, which is measured by reduction of cytochrome c, in rat liver microsomes (RLMs).	Tannins	0-11	cytochrome p450 oxidoreductase	Rattus norvegicus	105-108
21387315-1	2011	Tannic acid (TA) inhibits nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P450 reductase (CPR) activity, which is measured by reduction of cytochrome c, in rat liver microsomes (RLMs).	Tannins	13-15	cytochrome p450 oxidoreductase	Rattus norvegicus	105-108
21387315-2	2011	In the current study, we noticed that TA directly reduces cytochrome c in the absence of microsomes, thus confounding the CPR activity assay.	Tannins	38-40	cytochrome p450 oxidoreductase	Rattus norvegicus	122-125
21387315-7	2011	Additionally, inhibition of CPR by TA was associated with a significant reduction in reactive oxygen species and cell death after IR injury.	Tannins	35-37	cytochrome p450 oxidoreductase	Rattus norvegicus	28-31
21564015-5	2011	We tested 20 out of the 25 positive compounds in secondary confirmatory study and confirmed 12 compounds including Tannic acid as Cdc7-Dbf4 kinase inhibitors.	Tannins	115-126	cell division cycle 7	Homo sapiens	130-134
21564015-5	2011	We tested 20 out of the 25 positive compounds in secondary confirmatory study and confirmed 12 compounds including Tannic acid as Cdc7-Dbf4 kinase inhibitors.	Tannins	115-126	DBF4 zinc finger	Homo sapiens	135-139
21503579-9	2011	Taken together, these results suggest that tannic acid in HY agent may suppress GIC-induced production of PGE2 by inhibition of COX-2 expression in dental pulp cells.	Tannins	43-54	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	128-133
20874429-2	2010	This study aimed to determine the effects of resveratrol (RES) and tannic acid (TA), which are chemopreventive agents, on the nitric oxide synthase (NOS) levels that are effective for development of cancer in colon and breast cancer cell lines.	Tannins	67-78	nitric oxide synthase 2	Homo sapiens	126-147
21194538-3	2011	The present study aimed to evaluate the effect of tannic acid, a PARG/PARP inhibitor and an antioxidant, on doxorubicin-induced cardiotoxicity in H9c2 embryonic rat heart myoblasts and its anti-cancer activity in MDA-MB-231 human breast cancer cells as well as in DMBA-induced mammary tumor animals.	Tannins	50-61	poly (ADP-ribose) glycohydrolase	Rattus norvegicus	65-69
21194538-6	2011	Our results show that tannic acid prevents activation of PARP-1, reduces Bax and increases Bcl-2 expression in H9c2 cells, thus, preventing doxorubicin-induced cell death.	Tannins	22-33	poly (ADP-ribose) polymerase 1	Rattus norvegicus	57-63
21194538-6	2011	Our results show that tannic acid prevents activation of PARP-1, reduces Bax and increases Bcl-2 expression in H9c2 cells, thus, preventing doxorubicin-induced cell death.	Tannins	22-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	73-76
21194538-6	2011	Our results show that tannic acid prevents activation of PARP-1, reduces Bax and increases Bcl-2 expression in H9c2 cells, thus, preventing doxorubicin-induced cell death.	Tannins	22-33	BCL2, apoptosis regulator	Rattus norvegicus	91-96
21194538-7	2011	Further, it reduces the cell viability of MDA-MB-231 breast cancer cells, increases p53 expression in mammary tumors and shows maximum tumor volume reduction, suggesting that tannic acid potentiates the anti-cancer activity of doxorubicin.	Tannins	175-186	tumor protein p53	Homo sapiens	84-87
20581223-4	2010	Screening of drug and natural product collections identified tannic acid as an inhibitor of TMEM16A, with IC(50) ~ 6 muM and ~100% inhibition at higher concentrations.	Tannins	61-72	anoctamin 1	Homo sapiens	92-99
21084298-6	2011	Some compounds, such as tannic acid and the arylaminothiophene CaCC(inh)-A01, fully inhibited CaCC current in human bronchial and intestinal cells.	Tannins	24-35	anoctamin 1	Homo sapiens	94-98
20874429-2	2010	This study aimed to determine the effects of resveratrol (RES) and tannic acid (TA), which are chemopreventive agents, on the nitric oxide synthase (NOS) levels that are effective for development of cancer in colon and breast cancer cell lines.	Tannins	80-82	nitric oxide synthase 2	Homo sapiens	126-147
20054339-0	2010	Tannic acid and quercetin display a therapeutic effect in atopic dermatitis via suppression of angiogenesis and TARC expression in Nc/Nga mice.	Tannins	0-11	chemokine (C-C motif) ligand 17	Mus musculus	112-116
20851304-2	2010	The purpose of the review was to summarize the polyphenol, phenolic acid, and tannin (PPT) composition of raisins; predict the likely bioavailability of the component PPT; and summarize the results of human intervention studies involving raisins.	Tannins	78-84	tachykinin precursor 1	Homo sapiens	86-89
20054339-0	2010	Tannic acid and quercetin display a therapeutic effect in atopic dermatitis via suppression of angiogenesis and TARC expression in Nc/Nga mice.	Tannins	0-11	reticulon 4	Mus musculus	134-137
19395521-13	2009	This implies that tannin supplementation could be a useful strategy to increase the rumenic acid and PUFA content and to reduce the SFA in ruminant meats.	Tannins	18-24	PUFA	Ovis aries	101-105
20026373-3	2010	Tannic acid was the most potent inhibitor of the TPA-stimulated p65-DNA binding, while chlorogenic acid was the least effective compound.	Tannins	0-11	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	64-67
20026373-4	2010	Tannic acid also reduced the most the NF-kappaB p65 subunit translocation from cytosol to the nucleus and enhanced the retention of IkappaBalpha in the cytosol.	Tannins	0-11	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	48-51
20026373-4	2010	Tannic acid also reduced the most the NF-kappaB p65 subunit translocation from cytosol to the nucleus and enhanced the retention of IkappaBalpha in the cytosol.	Tannins	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	132-144
20026373-9	2010	The blockade of upstream kinase IKK signaling by tannic acid, but also by protocatechuic acid, inhibited the enzyme level and the activity of COX-2.	Tannins	49-60	cytochrome c oxidase II, mitochondrial	Mus musculus	142-147
19147685-0	2009	Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome.	Tannins	0-11	polypyrimidine tract binding protein 1	Homo sapiens	42-78
19442238-7	2009	Impairment of plasma membrane fusion and internalization by treatment with tannic acid does affect the trafficking of GAP-43 from plasma membrane to recycling endosomes which reveals a vesicle-mediated retrograde trafficking of GAP-43.	Tannins	75-86	neuromodulin	Cricetulus griseus	118-124
19442238-7	2009	Impairment of plasma membrane fusion and internalization by treatment with tannic acid does affect the trafficking of GAP-43 from plasma membrane to recycling endosomes which reveals a vesicle-mediated retrograde trafficking of GAP-43.	Tannins	75-86	neuromodulin	Cricetulus griseus	228-234
19147685-0	2009	Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome.	Tannins	0-11	cholinergic receptor nicotinic alpha 1 subunit	Homo sapiens	119-125
19147685-0	2009	Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome.	Tannins	0-11	heterogeneous nuclear ribonucleoprotein H2	Homo sapiens	145-152
19147685-4	2009	In an effort to search for a potential therapy, we screened off-label effects of 960 bioactive chemical compounds and found that tannic acid ameliorates the aberrant splicing due to IVS3-8G&gt;A but without altering the expression of hnRNP H.	Tannins	129-140	heterogeneous nuclear ribonucleoprotein H2	Homo sapiens	234-241
19147685-6	2009	We found that the polypyrimidine tract binding protein (PTB) binds close to the 3" end of CHRNA1 intron 3, that PTB induces skipping of exon P3A and that tannic acid increases the expression of PTB in a dose-dependent manner.	Tannins	154-165	polypyrimidine tract binding protein 1	Homo sapiens	18-54
19147685-6	2009	We found that the polypyrimidine tract binding protein (PTB) binds close to the 3" end of CHRNA1 intron 3, that PTB induces skipping of exon P3A and that tannic acid increases the expression of PTB in a dose-dependent manner.	Tannins	154-165	polypyrimidine tract binding protein 1	Homo sapiens	56-59
19147685-6	2009	We found that the polypyrimidine tract binding protein (PTB) binds close to the 3" end of CHRNA1 intron 3, that PTB induces skipping of exon P3A and that tannic acid increases the expression of PTB in a dose-dependent manner.	Tannins	154-165	cholinergic receptor nicotinic alpha 1 subunit	Homo sapiens	90-96
19147685-7	2009	Deletion assays of the PTB promoter region revealed that the tannic acid-responsive element is between positions -232 and -74 from the translation initiation site.	Tannins	61-72	polypyrimidine tract binding protein 1	Homo sapiens	23-26
17299386-9	2007	Effects of PLE and its isolated compounds (ellagic acid and tannic acid) on pancreatic lipase activity were examined in vitro.	Tannins	60-71	pancreatic lipase	Mus musculus	76-93
19154928-9	2009	Compared with the saline solution injection group, tannic acid treatment inhibited the matrix metalloproteinase-2/-9 activity and increased the collagen content at the early post-myocardial infarction stage (48.6 +/- 7.2 vs 37.3 +/- 6 microg/mg dry weight).	Tannins	51-62	matrix metallopeptidase 2	Rattus norvegicus	87-116
18650246-9	2008	BisX inhibition of VIP responses was abrogated when monolayers were pretreated with tannic acid to inhibit endosome recycling.	Tannins	84-95	vasoactive intestinal peptide	Homo sapiens	19-22
18550174-13	2008	It may conclude that tannic acid and curcumin as a chelating agent were more effective to reduce LPO levels in Al treatments group than Pb groups.	Tannins	21-32	lactoperoxidase	Rattus norvegicus	97-100
18291603-0	2008	Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation.	Tannins	0-11	poly (ADP-ribose) glycohydrolase	Mus musculus	117-121
18291603-3	2008	Recently, we have reported that tannic acid; a PARG inhibitor prevents cisplatin induced nephrotoxicity.	Tannins	32-43	poly (ADP-ribose) glycohydrolase	Mus musculus	47-51
18291603-7	2008	Treatment of tannic acid protects AZT induced hepatotoxicity by decreasing the ALT, AST and alkaline phosphatase levels.	Tannins	13-24	glutamic pyruvic transaminase, soluble	Mus musculus	79-82
18291603-7	2008	Treatment of tannic acid protects AZT induced hepatotoxicity by decreasing the ALT, AST and alkaline phosphatase levels.	Tannins	13-24	transmembrane protease, serine 11d	Mus musculus	84-87
18291603-9	2008	In addition, tannic acid decreases the PARG expression, PARP cleavage and histone H3 acetylation in liver of AZT treated mice.	Tannins	13-24	poly (ADP-ribose) glycohydrolase	Mus musculus	39-43
18291603-9	2008	In addition, tannic acid decreases the PARG expression, PARP cleavage and histone H3 acetylation in liver of AZT treated mice.	Tannins	13-24	poly (ADP-ribose) polymerase family, member 1	Mus musculus	56-60
17950511-6	2008	Tannic acid inhibited human CYP1A2 non-competitively with a Ki value of 4.8 microM.	Tannins	0-11	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	28-34
17637191-0	2007	Inhibition of P-glycoprotein function by tannic acid and pentagalloylglucose.	Tannins	41-52	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
17637191-1	2007	We studied the effects of tannic acid and 1(beta),2,3,4,6-penta-O-galloyl-D-glucose (pentagalloylglucose), one of the components of tannic acid, on the P-glycoprotein (P-gp) function in multidrug-resistant P-gp over-expressing KB-C2 cells.	Tannins	132-143	ATP binding cassette subfamily B member 1	Homo sapiens	152-166
17637191-2	2007	Both tannic acid and pentagalloylglucose markedly elevated the accumulation of P-gp substrates, rhodamine 123 and daunorubicin, by inhibiting their efflux.	Tannins	5-16	ATP binding cassette subfamily B member 1	Homo sapiens	79-83
17637191-5	2007	Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that inhibition of P-gp function by tannic acid and pentagalloylglucose was at least partly due to ATPase inhibition of P-gp.	Tannins	138-149	dynein axonemal heavy chain 8	Homo sapiens	33-39
17637191-5	2007	Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that inhibition of P-gp function by tannic acid and pentagalloylglucose was at least partly due to ATPase inhibition of P-gp.	Tannins	138-149	ATP binding cassette subfamily B member 1	Homo sapiens	87-91
17637191-5	2007	Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that inhibition of P-gp function by tannic acid and pentagalloylglucose was at least partly due to ATPase inhibition of P-gp.	Tannins	138-149	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
17637191-5	2007	Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that inhibition of P-gp function by tannic acid and pentagalloylglucose was at least partly due to ATPase inhibition of P-gp.	Tannins	138-149	dynein axonemal heavy chain 8	Homo sapiens	201-207
17637191-5	2007	Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that inhibition of P-gp function by tannic acid and pentagalloylglucose was at least partly due to ATPase inhibition of P-gp.	Tannins	138-149	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
17474755-1	2007	Binding parameters for the interactions of pentagalloyl glucose (PGG) and four hydrolyzable tannins (representing gallotannins and ellagitannins) with gelatin and bovine serum albumin (BSA) have been determined from isothermal titration calorimetry data.	Tannins	92-99	albumin	Homo sapiens	170-183
17470369-4	2007	Post-treatment of tannic acid prevents cisplatin (5mg/kg) induced nephrotoxicity and decreases poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4.	Tannins	18-29	mitogen activated protein kinase 14	Rattus norvegicus	152-155
17624241-0	2007	Tannic acid induces in vitro acantholysis of keratinocytes via IL-1alpha and TNF-alpha.	Tannins	0-11	interleukin 1 alpha	Homo sapiens	63-72
17477307-5	2007	Tannic acid (0.2 mM) also inhibited lactase (18% in adult and 71% in suckling animals), maltase (76%) and trehalase (88%) activities in rat intestine.	Tannins	0-11	lactase	Rattus norvegicus	36-43
17624241-0	2007	Tannic acid induces in vitro acantholysis of keratinocytes via IL-1alpha and TNF-alpha.	Tannins	0-11	tumor necrosis factor	Homo sapiens	77-86
17624241-11	2007	A blocking study using anti IL-1 alpha and anti TNF-alpha antibodies showed a reduction in TA-induced acantholysis.	Tannins	91-93	interleukin 1 alpha	Homo sapiens	28-38
17624241-11	2007	A blocking study using anti IL-1 alpha and anti TNF-alpha antibodies showed a reduction in TA-induced acantholysis.	Tannins	91-93	tumor necrosis factor	Homo sapiens	48-57
16527345-3	2006	Tannic acid (TA), a poly galloyl glucose (Glc), is compatible with Glut fixation, binds to vascular elastin, improves resistance to degradation and reduces in vivo calcification.	Tannins	0-11	elastin	Homo sapiens	100-107
17431106-3	2007	Mdr2-KO and age-matched Mdr2 heterozygous control mice were fed with tannic acid or selenomethionine during the first 3 months of life.	Tannins	69-80	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-4
17431106-7	2007	Both tannic acid and selenomethionine had partial chemopreventive effect on development of hepatocellular carcinoma in Mdr2-KO mice: they reduced the incidence of large tumor nodules (diameter &gt;1 cm) at age 16 months.	Tannins	5-16	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	119-123
17069924-9	2007	Tannic acid decreased calcein efflux and the expression of PGP, MRP1 and MRP2 membrane efflux pumps.	Tannins	0-11	phosphoglycolate phosphatase	Homo sapiens	59-62
17069924-9	2007	Tannic acid decreased calcein efflux and the expression of PGP, MRP1 and MRP2 membrane efflux pumps.	Tannins	0-11	ATP binding cassette subfamily C member 1	Homo sapiens	64-68
17069924-9	2007	Tannic acid decreased calcein efflux and the expression of PGP, MRP1 and MRP2 membrane efflux pumps.	Tannins	0-11	ATP binding cassette subfamily C member 2	Homo sapiens	73-77
16890919-4	2006	In presence of the salivary protein Histatin5 (Hst5) the rate of transport (dC/dt) of pentagalloyl glucose (5GG), a tannic acid, across Caco-2 cells in culture was reduced maximally 3.6-fold to 5x10(-7)microM/s in apical to basolateral direction.	Tannins	116-127	histatin 3	Homo sapiens	36-45
16890919-4	2006	In presence of the salivary protein Histatin5 (Hst5) the rate of transport (dC/dt) of pentagalloyl glucose (5GG), a tannic acid, across Caco-2 cells in culture was reduced maximally 3.6-fold to 5x10(-7)microM/s in apical to basolateral direction.	Tannins	116-127	histatin 3	Homo sapiens	47-51
16842597-0	2006	UVB-induced interleukin-18 production is downregulated by tannic acids in human HaCaT keratinocytes.	Tannins	58-70	interleukin 18	Homo sapiens	12-26
16842597-9	2006	Moreover, TA-inhibited UVB enhanced the expression of the inflammatory mediators, IL-1, IL-6, tumor necrotic factor-alpha, cyclooxygenase-2 and prostaglandin E(2) in UVB-irradiated HaCaT cells.	Tannins	10-12	interleukin 6	Homo sapiens	88-121
16842597-9	2006	Moreover, TA-inhibited UVB enhanced the expression of the inflammatory mediators, IL-1, IL-6, tumor necrotic factor-alpha, cyclooxygenase-2 and prostaglandin E(2) in UVB-irradiated HaCaT cells.	Tannins	10-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	123-139
17725526-5	2007	Tannic acid administration before TAA treatment also resulted in a significant decrease in ODC activity and [3H]-thymidine incorporation in rat liver, which are classical markers of inflammation and tumor promotion.	Tannins	0-11	ornithine decarboxylase 1	Rattus norvegicus	91-94
17118359-6	2006	Both curcumin and TA inhibited glutamate-induced caspase-3 activation.	Tannins	18-20	caspase 3	Homo sapiens	49-58
16527345-7	2006	Furthermore, we show that PGG, the core structure of TA, possesses the same unique elastin-stabilizing qualities of TA, yet it is much less cytotoxic than TA and thus could be potentially useful as an elastin-stabilizing agent for cardiovascular bioprostheses.	Tannins	53-55	elastin	Homo sapiens	83-90
16527345-7	2006	Furthermore, we show that PGG, the core structure of TA, possesses the same unique elastin-stabilizing qualities of TA, yet it is much less cytotoxic than TA and thus could be potentially useful as an elastin-stabilizing agent for cardiovascular bioprostheses.	Tannins	53-55	elastin	Homo sapiens	201-208
16527345-7	2006	Furthermore, we show that PGG, the core structure of TA, possesses the same unique elastin-stabilizing qualities of TA, yet it is much less cytotoxic than TA and thus could be potentially useful as an elastin-stabilizing agent for cardiovascular bioprostheses.	Tannins	116-118	elastin	Homo sapiens	83-90
16527345-7	2006	Furthermore, we show that PGG, the core structure of TA, possesses the same unique elastin-stabilizing qualities of TA, yet it is much less cytotoxic than TA and thus could be potentially useful as an elastin-stabilizing agent for cardiovascular bioprostheses.	Tannins	116-118	elastin	Homo sapiens	83-90
16527345-3	2006	Tannic acid (TA), a poly galloyl glucose (Glc), is compatible with Glut fixation, binds to vascular elastin, improves resistance to degradation and reduces in vivo calcification.	Tannins	13-15	elastin	Homo sapiens	100-107
16786837-5	2006	The administration of 20 mg tannic acid/kg body weight three times a week every other day for three weeks, enhanced the endogenous antioxidant capacity of the cells by increasing the activities of antioxidant enzymes (SOD, CAT, GSH-R, GST), GSH content and serum Cu and Zn levels.	Tannins	28-39	catalase	Mus musculus	223-226
16756330-0	2006	Monitoring and estimation of the kinetics parameters in the binding process of tannic acid to bovine serum albumin with electrochemical quartz crystal impedance system.	Tannins	79-90	albumin	Homo sapiens	101-114
16786837-5	2006	The administration of 20 mg tannic acid/kg body weight three times a week every other day for three weeks, enhanced the endogenous antioxidant capacity of the cells by increasing the activities of antioxidant enzymes (SOD, CAT, GSH-R, GST), GSH content and serum Cu and Zn levels.	Tannins	28-39	hematopoietic prostaglandin D synthase	Mus musculus	235-238
16263304-0	2006	Interactions of tannic acid and its derivatives (ellagic and gallic acid) with calf thymus DNA and bovine serum albumin using spectroscopic method.	Tannins	16-27	albumin	Bos taurus	106-119
16567414-0	2006	Tannic acid, a potent inhibitor of epidermal growth factor receptor tyrosine kinase.	Tannins	0-11	epidermal growth factor receptor	Homo sapiens	35-67
16567414-2	2006	In the present study, tannic acid was found to strongly inhibit tyrosine kinase activity of epidermal growth factor receptor (EGFr) in vitro (IC50 = 323 nM).	Tannins	22-33	epidermal growth factor receptor	Homo sapiens	92-124
16567414-2	2006	In the present study, tannic acid was found to strongly inhibit tyrosine kinase activity of epidermal growth factor receptor (EGFr) in vitro (IC50 = 323 nM).	Tannins	22-33	epidermal growth factor receptor	Homo sapiens	126-130
16567414-3	2006	In contrast, the inhibition by tannic acid of p60(c-src) tyrosine kinase (IC50 = 14 microM) and insulin receptor tyrosine kinase (IC50 = 5 microM) was much weaker.	Tannins	31-42	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	46-49
16567414-3	2006	In contrast, the inhibition by tannic acid of p60(c-src) tyrosine kinase (IC50 = 14 microM) and insulin receptor tyrosine kinase (IC50 = 5 microM) was much weaker.	Tannins	31-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-55
16567414-3	2006	In contrast, the inhibition by tannic acid of p60(c-src) tyrosine kinase (IC50 = 14 microM) and insulin receptor tyrosine kinase (IC50 = 5 microM) was much weaker.	Tannins	31-42	insulin receptor	Homo sapiens	96-112
16567414-4	2006	The inhibition of EGFr tyrosine kinase by tannic acid was competitive with respect to ATP and non-competitive with respect to peptide substrate.	Tannins	42-53	epidermal growth factor receptor	Homo sapiens	18-22
16567414-5	2006	In cultured cells, growth factor-induced tyrosine phosphorylation of growth factor receptors, including EGFr, platelet-derived growth factor receptor, and basic fibroblast growth factor receptor, was inhibited by tannic acid.	Tannins	213-224	epidermal growth factor receptor	Homo sapiens	104-108
16567414-9	2006	The molecular modeling study suggested that tannic acid could be docked into the ATP binding pockets of either EGFr or insulin receptor.	Tannins	44-55	epidermal growth factor receptor	Homo sapiens	111-115
16567414-9	2006	The molecular modeling study suggested that tannic acid could be docked into the ATP binding pockets of either EGFr or insulin receptor.	Tannins	44-55	insulin receptor	Homo sapiens	119-135
16567414-10	2006	These results demonstrate that tannic acid is an in vitro potent inhibitor of EGFr tyrosine kinase.	Tannins	31-42	epidermal growth factor receptor	Homo sapiens	78-82
16102811-2	2006	Recently, tannic acid (TA) and tannic acid mimicking dendrimers (TAMD) have been suggested as potential stabilization agents for collagen and elastin.	Tannins	10-21	elastin	Homo sapiens	142-149
16102811-2	2006	Recently, tannic acid (TA) and tannic acid mimicking dendrimers (TAMD) have been suggested as potential stabilization agents for collagen and elastin.	Tannins	23-25	elastin	Homo sapiens	142-149
16102811-2	2006	Recently, tannic acid (TA) and tannic acid mimicking dendrimers (TAMD) have been suggested as potential stabilization agents for collagen and elastin.	Tannins	31-42	elastin	Homo sapiens	142-149
16194150-10	2006	Rim2p was strongly inhibited by mercurials, bathophenanthroline, tannic acid and Bromocresol Purple, and partially inhibited by bongkrekic acid.	Tannins	65-76	Rim2p	Saccharomyces cerevisiae S288C	0-5
16686999-8	2006	The promotion parameters induced (ornithine decarboxylase activity and DNA synthesis) by 2-AAF administration in the diet with partial hepatectomy (PH) were also significantly suppressed, dose dependently, by tannic acid.	Tannins	209-220	ornithine decarboxylase 1	Rattus norvegicus	34-57
16137651-2	2005	We recently reported the insulin-like glucose transport stimulatory activity of tannic acid (TA) in 3T3-L1 adipocytes.	Tannins	80-91	insulin	Homo sapiens	25-32
16505580-4	2005	In addition, treatment with 1% tannic acid (TA) prior to the dehydration described above synergistically improved both the ultrastructure and antigenicity of the tissue so that the orientation of the Golgi apparatus could be determined by double immunogold labeling with commercially available anti-GM130 and anti-TGN38 antibodies.	Tannins	31-42	trans-golgi network protein 2	Homo sapiens	314-319
16505580-4	2005	In addition, treatment with 1% tannic acid (TA) prior to the dehydration described above synergistically improved both the ultrastructure and antigenicity of the tissue so that the orientation of the Golgi apparatus could be determined by double immunogold labeling with commercially available anti-GM130 and anti-TGN38 antibodies.	Tannins	44-46	trans-golgi network protein 2	Homo sapiens	314-319
16039063-7	2005	The three most potent inhibitors of both murine and ovine PrP-res formation (with 50% inhibition at < or =5 microM) were tannic acid, pentosan polysulfate and Fe(III) deuteroporphyrin 2,4-bisethyleneglycol.	Tannins	121-132	prion protein	Mus musculus	58-61
16137651-2	2005	We recently reported the insulin-like glucose transport stimulatory activity of tannic acid (TA) in 3T3-L1 adipocytes.	Tannins	93-95	insulin	Homo sapiens	25-32
15920152-7	2005	The anti-proliferative effect of tannic acid was associated with a reduction of ERK1,2 phosphorylation.	Tannins	33-44	mitogen-activated protein kinase 3	Homo sapiens	80-86
15920152-11	2005	In conclusion, the anti-proliferative effects of tannic acid in cholangiocytes involve modulation of ERK1,2 by a cyclic adenosine 5",3"-monophosphate-protein kinase A-dependent pathway.	Tannins	49-60	mitogen-activated protein kinase 3	Homo sapiens	101-107
12865094-4	2003	Nine tannins with an IC50 &lt;200 microM for ACE inhibitors were identified belonging to three tannin classes: caffeoylquinates, flavan-3-ols and gallotannins.	Tannins	5-12	angiotensin I converting enzyme	Rattus norvegicus	45-48
15475053-3	2005	The aim of our studies was to develop novel tissue-processing techniques targeted specifically at elastin stabilization by using tannic acid (TA), a plant polyphenol capable of protecting elastin from digestion by specific enzymes.	Tannins	129-140	elastin	Rattus norvegicus	98-105
15475053-3	2005	The aim of our studies was to develop novel tissue-processing techniques targeted specifically at elastin stabilization by using tannic acid (TA), a plant polyphenol capable of protecting elastin from digestion by specific enzymes.	Tannins	129-140	elastin	Rattus norvegicus	188-195
15475053-3	2005	The aim of our studies was to develop novel tissue-processing techniques targeted specifically at elastin stabilization by using tannic acid (TA), a plant polyphenol capable of protecting elastin from digestion by specific enzymes.	Tannins	142-144	elastin	Rattus norvegicus	98-105
15475053-3	2005	The aim of our studies was to develop novel tissue-processing techniques targeted specifically at elastin stabilization by using tannic acid (TA), a plant polyphenol capable of protecting elastin from digestion by specific enzymes.	Tannins	142-144	elastin	Rattus norvegicus	188-195
15358184-1	2004	A cDNA encoding a rat Smubp-2 has been cloned from a lambdagt11 library by South-Western blot screening using a 50-bp tannic acid responsive element [J. Biol.	Tannins	118-129	immunoglobulin mu DNA binding protein 2	Homo sapiens	22-29
15321729-3	2004	The tannic acid derivative gallotannin inhibited PARG in a cell-free assay but had no detectable effect on PARG function in intact cells.	Tannins	4-15	poly(ADP-ribose) glycohydrolase	Homo sapiens	49-53
14980424-0	2004	Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid.	Tannins	113-124	elastin	Homo sapiens	0-7
14980424-4	2004	More specifically, we investigated the use of tannic acid (TA)1 as a novel agent that specifically targets elastin stabilization.	Tannins	46-57	elastin	Homo sapiens	107-114
14732485-9	2004	Also, PARG gene expression was reduced by tannic acid treatment.	Tannins	42-53	poly(ADP-ribose) glycohydrolase	Homo sapiens	6-10
15302093-13	2004	In kidney MC-induced activity of NQO1 was reduced (about 43%) to the control level by tannic acid pretreatment.	Tannins	86-97	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	33-37
14674884-7	2004	Unlike the yeast orthologue, SAMC catalysed virtually only countertransport, exhibited a higher transport affinity for SAM and was strongly inhibited by tannic acid and Bromocresol Purple.	Tannins	153-164	solute carrier family 25 member 26	Homo sapiens	29-33
14732485-2	2004	In this study, changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases (PARG) in HL-60 cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a PARG inhibitor, tannic acid, were investigated.	Tannins	198-209	poly(ADP-ribose) glycohydrolase	Homo sapiens	65-97
14732485-2	2004	In this study, changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases (PARG) in HL-60 cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a PARG inhibitor, tannic acid, were investigated.	Tannins	198-209	poly(ADP-ribose) glycohydrolase	Homo sapiens	99-103
14732485-6	2004	On the other hand, treatment with tannic acid caused the nuclear PARG activity to decrease continuously while the NBT reducing activity increased, but no morphological differentiation to macrophage-like cells was apparent.	Tannins	34-45	poly(ADP-ribose) glycohydrolase	Homo sapiens	65-69
12865094-4	2003	Nine tannins with an IC50 &lt;200 microM for ACE inhibitors were identified belonging to three tannin classes: caffeoylquinates, flavan-3-ols and gallotannins.	Tannins	5-11	angiotensin I converting enzyme	Rattus norvegicus	45-48
12912963-5	2003	EXPERIMENTAL DESIGN: The inhibitory effect of tannic acid on CXCL12/CXCR4 was measured by chemotaxis assay, ligand binding assay, and fluorescence-activated cell sorter analysis.	Tannins	46-57	C-X-C motif chemokine ligand 12	Homo sapiens	61-67
12912963-5	2003	EXPERIMENTAL DESIGN: The inhibitory effect of tannic acid on CXCL12/CXCR4 was measured by chemotaxis assay, ligand binding assay, and fluorescence-activated cell sorter analysis.	Tannins	46-57	C-X-C motif chemokine receptor 4	Homo sapiens	68-73
12912963-0	2003	Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity.	Tannins	0-11	C-X-C motif chemokine ligand 12	Homo sapiens	31-37
12912963-0	2003	Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity.	Tannins	0-11	C-X-C motif chemokine receptor 4	Homo sapiens	51-56
12912963-4	2003	The aim of this study was to assess the anti-CXCL12/CXCR4 activity of a commercial tannic acid and evaluate its potential to inhibit tumor cell migration and angiogenesis in vitro.	Tannins	83-94	C-X-C motif chemokine ligand 12	Homo sapiens	45-51
12912963-4	2003	The aim of this study was to assess the anti-CXCL12/CXCR4 activity of a commercial tannic acid and evaluate its potential to inhibit tumor cell migration and angiogenesis in vitro.	Tannins	83-94	C-X-C motif chemokine receptor 4	Homo sapiens	52-57
12912963-7	2003	RESULTS: Tannic acid, at nontoxic concentrations, specifically inhibited CXCL12-induced human monocyte migration (IC(50), 7.5 micro g/ml) but did not inhibit CCL2-, CCL3-, CCL5-, formylmethionylleucylphenylalanine (fMLP)-, or C5a-induced migration.	Tannins	9-20	C-X-C motif chemokine ligand 12	Homo sapiens	73-79
12912963-7	2003	RESULTS: Tannic acid, at nontoxic concentrations, specifically inhibited CXCL12-induced human monocyte migration (IC(50), 7.5 micro g/ml) but did not inhibit CCL2-, CCL3-, CCL5-, formylmethionylleucylphenylalanine (fMLP)-, or C5a-induced migration.	Tannins	9-20	C-C motif chemokine ligand 3	Homo sapiens	165-169
12912963-7	2003	RESULTS: Tannic acid, at nontoxic concentrations, specifically inhibited CXCL12-induced human monocyte migration (IC(50), 7.5 micro g/ml) but did not inhibit CCL2-, CCL3-, CCL5-, formylmethionylleucylphenylalanine (fMLP)-, or C5a-induced migration.	Tannins	9-20	C-C motif chemokine ligand 5	Homo sapiens	172-176
12912963-9	2003	Tannic acid also inhibited CXCL12-induced, but not epidermal growth factor-induced, migration of MDA 231 breast tumor cells.	Tannins	0-11	C-X-C motif chemokine ligand 12	Homo sapiens	27-33
12912963-10	2003	Additionally, 0.5 micro g/ml of tannic acid selectively inhibited CXCL12-mediated, but not basic fibroblast growth factor- or endothelial cell growth supplement-mediated, bovine aorta endothelial cell capillary tube formation.	Tannins	32-43	C-X-C motif chemokine ligand 12	Bos taurus	66-72
12912963-11	2003	CONCLUSION: These studies indicate that tannic acid is a novel selective CXCL12/CXCR4 antagonist and consequently may provide a mechanistic basis for the reported antitumor and anti-inflammatory properties of tannic acid.	Tannins	40-51	C-X-C motif chemokine ligand 12	Homo sapiens	73-79
12912963-11	2003	CONCLUSION: These studies indicate that tannic acid is a novel selective CXCL12/CXCR4 antagonist and consequently may provide a mechanistic basis for the reported antitumor and anti-inflammatory properties of tannic acid.	Tannins	40-51	C-X-C motif chemokine receptor 4	Homo sapiens	80-85
12912963-11	2003	CONCLUSION: These studies indicate that tannic acid is a novel selective CXCL12/CXCR4 antagonist and consequently may provide a mechanistic basis for the reported antitumor and anti-inflammatory properties of tannic acid.	Tannins	209-220	C-X-C motif chemokine ligand 12	Homo sapiens	73-79
12912963-11	2003	CONCLUSION: These studies indicate that tannic acid is a novel selective CXCL12/CXCR4 antagonist and consequently may provide a mechanistic basis for the reported antitumor and anti-inflammatory properties of tannic acid.	Tannins	209-220	C-X-C motif chemokine receptor 4	Homo sapiens	80-85
12672508-7	2003	The plant polyphenols namely tannic acid, butein, quercetin, morin, 2-hydroxychalcone and 2"-hydroxychalcone at 40 microM inhibited the GST-mediated conjugation of CMB with GSH by 38 to 62%.	Tannins	29-40	glutathione S-transferase kappa 1	Homo sapiens	136-139
12749824-6	2003	Moreover, Western blot analysis with CYP2E1 specific antibody showed a significant decrease in the levels of hepatic CYP2E1 in tannic acid treated animals.	Tannins	127-138	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	37-43
12749824-6	2003	Moreover, Western blot analysis with CYP2E1 specific antibody showed a significant decrease in the levels of hepatic CYP2E1 in tannic acid treated animals.	Tannins	127-138	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	117-123
12749824-8	2003	The activity of GST was elevated in kidneys, but reduced in livers of the animals treated with tannic acid.	Tannins	95-106	hematopoietic prostaglandin D synthase	Mus musculus	16-19
12049231-7	2002	There was no consistent evidence of a trade-off between tannin concentrations and growth rate, but there was a positive correlation between mean thorn length and mean tannin concentrations across species of ant inhabitants and across herbivore treatments in 1997.	Tannins	167-173	solute carrier family 25 member 6	Homo sapiens	207-210
11421463-8	2001	Their in vitro TNF-inducing potential producing 50% lysis in murine L929 cells increased in the order of simple phenols and flavanols (34-48 U/ml) &lt; A-type proanthocyanidins (53-80 U/ml) &lt; B-type proanthocyanidins (64-200 U/ml) &lt; hydrolyzable tannins (287-350 U/ml) at the host cell subtoxic concentration of 50 microg/ml.	Tannins	252-259	tumor necrosis factor	Mus musculus	15-18
12545198-5	2002	These results indicate that trans-resveratrol and tannic acid may modulate cytochrome P450 2E1 and influence the metabolic activation of xenobiotics mediated by this P450 isoform.	Tannins	50-61	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	75-94
11588135-0	2001	Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis.	Tannins	0-11	zinc ribbon domain containing 2	Homo sapiens	72-75
11588135-0	2001	Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis.	Tannins	0-11	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Tannins	82-93	glutathione S-transferase kappa 1	Homo sapiens	159-162
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Tannins	82-93	ATP binding cassette subfamily C member 1	Homo sapiens	167-171
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Tannins	82-93	glutathione S-transferase kappa 1	Homo sapiens	33-36
11259628-7	2001	On the other hand, inhibition of GST and GS-X pump by ethacrynic acid, quercetin, tannic acid, and indomethacin at concentrations that inhibited activities of GST and GS-X pump by more than 50% had no significant effects on cisplatin cytotoxicity and cisplatin-induced DNA ICL in these cells.	Tannins	82-93	ATP binding cassette subfamily C member 1	Homo sapiens	41-45
9783826-8	1998	Deglycosylation of a GPRP also led to a dramatic increase in tannin-binding ability, showing that the carbohydrate side-chains prevent binding of tannin.	Tannins	61-67	glutathione peroxidase 2	Homo sapiens	21-25
11226036-1	2001	The effect of tannic acid, a common flavonoid, on the acrosin and plasminogen activator activity and plasmin activity of human and ram spermatozoa was evaluated.	Tannins	14-25	acrosin	Homo sapiens	54-61
11226036-1	2001	The effect of tannic acid, a common flavonoid, on the acrosin and plasminogen activator activity and plasmin activity of human and ram spermatozoa was evaluated.	Tannins	14-25	plasminogen	Homo sapiens	66-73
11226036-3	2001	In extracts from both human and ovine acrosomes, the activities of acrosin and plasminogen activators were susceptible to tannic acid inhibition.	Tannins	122-133	acrosin	Homo sapiens	67-74
11226036-5	2001	In additional experiments, low concentrations of tannic acid significantly inhibited tissue-type plasminogen activator, urokinase-type plasminogen activator and plasmin activity in a concentration-dependent manner over the range 0.25-200 micromol l(-1).	Tannins	49-60	plasminogen	Homo sapiens	97-104
11226036-8	2001	These results indicate that tannic acid inhibited the activity of both acrosin and plasminogen activator and indicates a possible mechanism by which flavonoids exert their antifertility effects.	Tannins	28-39	acrosin	Homo sapiens	71-78
9929694-0	1998	Effect of gelatin (a model for salivary PRP) on the sensory astringency of 5-O-caffeoylquinic acid and tannic acid.	Tannins	103-114	prion protein	Homo sapiens	40-43
11204497-1	2000	BACKGROUND: This study was undertaken to investigate if low-dose dietary administration of tannic acid exerts its chemopreventive activity on hepatocarcinogenesis in male C3H mice through changes of plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) or plasmin inhibition (Pl) in the liver of C3H hepatoma bearing male mice.	Tannins	91-102	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	271-274
10675538-0	2000	Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH.	Tannins	93-104	tumor necrosis factor	Mus musculus	0-21
10794615-2	1999	The condensed tannin-binding region of histatin 5 includes both the N- and the C-terminal parts, although more tannin binding occurs in the C-terminal region.	Tannins	14-20	histatin 3	Homo sapiens	39-49
10794615-2	1999	The condensed tannin-binding region of histatin 5 includes both the N- and the C-terminal parts, although more tannin binding occurs in the C-terminal region.	Tannins	111-117	histatin 3	Homo sapiens	39-49
9783826-8	1998	Deglycosylation of a GPRP also led to a dramatic increase in tannin-binding ability, showing that the carbohydrate side-chains prevent binding of tannin.	Tannins	146-152	glutathione peroxidase 2	Homo sapiens	21-25
8646768-3	1996	Cultures treated with TNF-alpha (alone or in combination with IL-1 beta) showed several mesenchymal cells with numerous irregularly shaped membrane-bordered cavities containing thick bundled tannic-acid-positive fibrillar structures that resembled loosened collagen fibrils, whereas cells exposed to IL-1 beta alone did not exhibit such changes.	Tannins	191-202	tumor necrosis factor	Mus musculus	22-31
9596764-2	1998	Although all isolates possessing the MrkD adhesin mediate the agglutination, in vitro, of erythrocytes treated with tannic acid, the mrkD gene is not conserved within species.	Tannins	116-127	MrkD	Klebsiella pneumoniae	37-41
9093380-1	1997	Aqueous solutions of gallic acid, methyl gallate, catechins, theaflavins and tannic acid were tested for inhibition of the mutagenicity of PhIP in the Salmonella typhimurium TA98 assay with an S9 fraction from the liver of rats induced with alpha-naphthoflavone and phenobarbital.	Tannins	77-88	pleckstrin homology domain interacting protein	Rattus norvegicus	139-143
8646768-3	1996	Cultures treated with TNF-alpha (alone or in combination with IL-1 beta) showed several mesenchymal cells with numerous irregularly shaped membrane-bordered cavities containing thick bundled tannic-acid-positive fibrillar structures that resembled loosened collagen fibrils, whereas cells exposed to IL-1 beta alone did not exhibit such changes.	Tannins	191-202	interleukin 1 beta	Mus musculus	62-71
7575474-7	1995	At pH 7.4 histatin 5 was the most effective precipitant of both condensed tannin and tannic acid and it also precipitated the largest amount of condensed tannin at pH 3.0, but the smallest amount of tannic acid at that pH.	Tannins	85-96	histatin 3	Homo sapiens	10-20
7575474-7	1995	At pH 7.4 histatin 5 was the most effective precipitant of both condensed tannin and tannic acid and it also precipitated the largest amount of condensed tannin at pH 3.0, but the smallest amount of tannic acid at that pH.	Tannins	199-210	histatin 3	Homo sapiens	10-20
7575474-8	1995	In contrast PRP-1 showed a greater ability to precipitate both condensed tannin and tannic acid at pH 3.0 than at pH 7.4.	Tannins	84-95	complement component 4 binding protein alpha	Homo sapiens	12-17
7653998-7	1995	Various hydrolyzable tannins, condensed tannins (CTs) and their monomeric units remarkably inhibit the ODC response to multiple CPBA treatments.	Tannins	21-28	ornithine decarboxylase, structural 1	Mus musculus	103-106
7653998-8	1995	At 12 mg, gallic acid, Aleppo gall tannic acid (TA), catechin, and loblolly pine bark CT inhibit the most CPBA-induced ODC activity.	Tannins	35-46	ornithine decarboxylase, structural 1	Mus musculus	119-122
7653998-8	1995	At 12 mg, gallic acid, Aleppo gall tannic acid (TA), catechin, and loblolly pine bark CT inhibit the most CPBA-induced ODC activity.	Tannins	48-50	ornithine decarboxylase, structural 1	Mus musculus	119-122
7607300-0	1995	Tannic acid inhibits insulin-stimulated lipogenesis in rat adipose tissue and insulin receptor function in vitro.	Tannins	0-11	insulin receptor	Rattus norvegicus	78-94
7607300-8	1995	However, insulin-stimulated autophosphorylation of the insulin receptor, and receptor-associated tyrosine kinase phosphorylation of RR-SRC peptide, were inhibited by tannic acid at concentrations as low as 25 microM.	Tannins	166-177	insulin receptor	Rattus norvegicus	55-71
8173637-6	1994	Tannic acid initially reduced (p &lt; 0.05) both the concentration and the total amount of Fel d I by 30% and Can f I by 10%, but only for one week.	Tannins	0-11	major allergen I polypeptide chain 2	Felis catus	91-98
1338273-1	1992	Iodination stimulators, such as the dehydrogenation polymer of caffeic acid (DHP-CA), a protein-bound polysaccharide (PSK), and a commercially available tannic acid, potently inhibited the luciferin-dependent chemiluminescence (LDCL) generated by opsonized zymosan-stimulated human peripheral blood polymorphonuclear cells (PMN).	Tannins	153-164	TAO kinase 2	Homo sapiens	118-121
1802710-5	1991	Discharge of tannic acid-osmium stained fibrinogen from alpha granules to channels of the OCS and platelet exterior was, on the other hand, time and thrombin concentration dependent.	Tannins	13-24	coagulation factor II, thrombin	Homo sapiens	149-157
1465502-4	1992	In sheep given tannic acid intraperitoneally (0.1 g kg-1 bodyweight), liver necrosis occurred and plasma sodium and glucose levels significantly (P &lt; 0.05) decreased while packed cell volume and plasma aspartate aminotransferase, alkaline phosphatase, creatinine and bilirubin significantly (P &lt; 0.01) rose.	Tannins	15-26	aspartate aminotransferase, mitochondrial	Ovis aries	205-231
1733406-5	1992	Electron microscopic examination with tannic acid staining revealed that the elastin in the stroma was composed mainly of amorphous material surrounded by a small amount of microfibrils and abundant collagen fibers.	Tannins	38-49	elastin	Homo sapiens	77-84
1811885-7	1991	Thereafter, a tannic acid-positive, patchy material appeared in the extracellular space of CA 1 and L 261 and aggregated to form small fragments of a discontinuous BL.	Tannins	14-25	carbonic anhydrase 1	Homo sapiens	91-95
1522762-12	1992	However, hepatic lipase activity in rats fed tannic acid was significantly lower.	Tannins	45-56	lipase C, hepatic type	Rattus norvegicus	9-23
1836964-3	1991	Extracellular core-like structures found in atria treated with tannic acid are also shown to contain atrial natriuretic peptide.	Tannins	63-74	natriuretic peptide A	Rattus norvegicus	101-127
1839253-0	1991	[Protective effect of tannic acid against TPA- and cigarette smoke condensate-induced DNA strand breaks in human white cells and its antioxidant action].	Tannins	22-33	plasminogen activator, tissue type	Homo sapiens	42-45
1704157-7	1990	Higher concentrations of tannic acid give increased electron density, especially to elastin, and can therefore be used as an elastin stain.	Tannins	25-36	elastin	Homo sapiens	84-91
2032222-0	1991	Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo.	Tannins	73-84	ornithine decarboxylase, structural 1	Mus musculus	37-60
2032222-2	1991	Topical applications of tannic acid (TA) inhibit remarkably and in a dose-dependent manner TPA-induced ODC activity in mouse epidermis in vivo.	Tannins	24-35	ornithine decarboxylase, structural 1	Mus musculus	103-106
2032222-2	1991	Topical applications of tannic acid (TA) inhibit remarkably and in a dose-dependent manner TPA-induced ODC activity in mouse epidermis in vivo.	Tannins	37-39	ornithine decarboxylase, structural 1	Mus musculus	103-106
2032222-4	1991	The induction of epidermal ODC activity by 8.5 nmol of TPA is inhibited maximally when 20 mumol of TA are applied topically to the skin 20 min before the tumor promoter.	Tannins	99-101	ornithine decarboxylase, structural 1	Mus musculus	27-30
2032222-8	1991	The ability of TA to inhibit by 85% the ODC marker of skin tumor promotion suggests that TA and other polyphenols may be effective not only against tumor initiation and complete carcinogenesis but also against the promotion phase of tumorigenesis.	Tannins	15-17	ornithine decarboxylase, structural 1	Mus musculus	40-43
2032222-8	1991	The ability of TA to inhibit by 85% the ODC marker of skin tumor promotion suggests that TA and other polyphenols may be effective not only against tumor initiation and complete carcinogenesis but also against the promotion phase of tumorigenesis.	Tannins	89-91	ornithine decarboxylase, structural 1	Mus musculus	40-43
1779486-4	1991	This was confirmed by the tannic acid-uranyl acetate staining which reacts specifically with elastin.	Tannins	26-37	elastin	Homo sapiens	93-100
1704157-7	1990	Higher concentrations of tannic acid give increased electron density, especially to elastin, and can therefore be used as an elastin stain.	Tannins	25-36	elastin	Homo sapiens	125-132
19210371-6	1990	Stimulation of dendrosomes with 56 mM potassium in the presence of tannic acid, which preserves exocytosed granule cores so that they can be visualized electron microscopically, demonstrates that, in response to a depolarizing stimulus, dendrosomes are capable of secreting by exocytosis the neuropeptides oxytocin (OT) and vasopressin (VP) and their co-packaged neurophysins.	Tannins	67-78	arginine vasopressin	Homo sapiens	324-335
2257612-5	1990	Elastin was enclosed by microfibrils, thus forming the elastic fiber, which was clearly demonstrated by tannic acid-uranyl acetate staining.	Tannins	104-115	elastin	Mus musculus	0-7
19210371-6	1990	Stimulation of dendrosomes with 56 mM potassium in the presence of tannic acid, which preserves exocytosed granule cores so that they can be visualized electron microscopically, demonstrates that, in response to a depolarizing stimulus, dendrosomes are capable of secreting by exocytosis the neuropeptides oxytocin (OT) and vasopressin (VP) and their co-packaged neurophysins.	Tannins	67-78	arginine vasopressin	Homo sapiens	337-339
34823455-4	2022	OBJECTIVE: Thus, the objective of this study was to investigate the effect of Tannic acid on humoral and cell-mediated immunity against bovine serum albumin (BSA) as a protein antigen in Wistar rats.	Tannins	78-89	albumin	Rattus norvegicus	143-156
2210874-8	1990	Contaminating endotoxin present in the tannin preparation accounted for the majority of IL-1 beta released from monocytes alone stimulated with tannin, but only 20% of the IL-1 beta released from tannin-stimulated monocyte-T-lymphocyte co-cultures.	Tannins	39-45	interleukin 1 beta	Homo sapiens	88-97
2210874-8	1990	Contaminating endotoxin present in the tannin preparation accounted for the majority of IL-1 beta released from monocytes alone stimulated with tannin, but only 20% of the IL-1 beta released from tannin-stimulated monocyte-T-lymphocyte co-cultures.	Tannins	144-150	interleukin 1 beta	Homo sapiens	88-97
26363229-2	2015	Surprisingly, only SERPINe1-derived 14-mer peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of VHSV, but also of other fish rhabdoviruses such as infectious hematopoietic necrosis virus (IHNV) and spring viremia carp virus (SVCV).	Tannins	107-118	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	Danio rerio	19-27
34841741-4	2022	The photothermal MPNs were assembled via coordination between tannic acid (TA) and metal ion complex of Fe3+ /Mn2+ , through which a PD-L1 inhibiting DNAzyme (DZ) was loaded to regulate the immunosuppressive PD-1/PD-L1 pathway.	Tannins	62-73	CD274 molecule	Homo sapiens	133-138
34841741-4	2022	The photothermal MPNs were assembled via coordination between tannic acid (TA) and metal ion complex of Fe3+ /Mn2+ , through which a PD-L1 inhibiting DNAzyme (DZ) was loaded to regulate the immunosuppressive PD-1/PD-L1 pathway.	Tannins	62-73	programmed cell death 1	Homo sapiens	208-212
34841741-4	2022	The photothermal MPNs were assembled via coordination between tannic acid (TA) and metal ion complex of Fe3+ /Mn2+ , through which a PD-L1 inhibiting DNAzyme (DZ) was loaded to regulate the immunosuppressive PD-1/PD-L1 pathway.	Tannins	62-73	CD274 molecule	Homo sapiens	213-218
34841741-4	2022	The photothermal MPNs were assembled via coordination between tannic acid (TA) and metal ion complex of Fe3+ /Mn2+ , through which a PD-L1 inhibiting DNAzyme (DZ) was loaded to regulate the immunosuppressive PD-1/PD-L1 pathway.	Tannins	75-77	CD274 molecule	Homo sapiens	133-138
34841741-4	2022	The photothermal MPNs were assembled via coordination between tannic acid (TA) and metal ion complex of Fe3+ /Mn2+ , through which a PD-L1 inhibiting DNAzyme (DZ) was loaded to regulate the immunosuppressive PD-1/PD-L1 pathway.	Tannins	75-77	programmed cell death 1	Homo sapiens	208-212
34841741-4	2022	The photothermal MPNs were assembled via coordination between tannic acid (TA) and metal ion complex of Fe3+ /Mn2+ , through which a PD-L1 inhibiting DNAzyme (DZ) was loaded to regulate the immunosuppressive PD-1/PD-L1 pathway.	Tannins	75-77	CD274 molecule	Homo sapiens	213-218
33803294-4	2021	Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-beta1/TGF-beta1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes.	Tannins	0-11	zinc fingers and homeoboxes 2	Homo sapiens	118-121
33803294-4	2021	Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-beta1/TGF-beta1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes.	Tannins	0-11	mechanistic target of rapamycin kinase	Homo sapiens	122-126
33803294-4	2021	Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-beta1/TGF-beta1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes.	Tannins	0-11	transforming growth factor beta 1	Homo sapiens	128-137
33803294-4	2021	Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-beta1/TGF-beta1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes.	Tannins	0-11	vascular endothelial growth factor A	Homo sapiens	155-159
33803294-4	2021	Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-beta1/TGF-beta1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes.	Tannins	0-11	kinase insert domain receptor	Homo sapiens	160-165
33803294-4	2021	Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-beta1/TGF-beta1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes.	Tannins	0-11	C-X-C motif chemokine ligand 12	Homo sapiens	170-176
33803294-4	2021	Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-beta1/TGF-beta1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes.	Tannins	0-11	C-X-C motif chemokine receptor 4	Homo sapiens	177-182
34883130-0	2022	Tannic acid reinforced electro-Fenton system based on GO-Fe3O4/NF cathode for the efficient catalytic degradation of PNP.	Tannins	0-11	neurofascin	Homo sapiens	63-65
34756033-2	2021	Herein we report a facile technique to construct a systemically applicable beta-galactosidase (beta-Gal)-loaded ternary complex comprising tannic acid (TA) and phenylboronic acid-conjugated polymers through sequential self-assembly in aqueous solution.	Tannins	139-150	galactosidase beta 1	Homo sapiens	75-93
34756033-2	2021	Herein we report a facile technique to construct a systemically applicable beta-galactosidase (beta-Gal)-loaded ternary complex comprising tannic acid (TA) and phenylboronic acid-conjugated polymers through sequential self-assembly in aqueous solution.	Tannins	152-154	galactosidase beta 1	Homo sapiens	75-93
34562517-0	2021	Tannic Acid Protects Aged Brain Against Cerebral Hypoperfusion via Modulation of Nrf2 and Inflammatory Pathways.	Tannins	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	81-85
34562517-6	2021	Furthermore, long-term TA treatment significantly increased the levels of Nrf2 (P<0.001), NQO-1 (P<0.001), and HO-1 (P<0.001) in the hippocampus of the treatment group compared to the UCCAO group.	Tannins	23-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	74-78
34562517-6	2021	Furthermore, long-term TA treatment significantly increased the levels of Nrf2 (P<0.001), NQO-1 (P<0.001), and HO-1 (P<0.001) in the hippocampus of the treatment group compared to the UCCAO group.	Tannins	23-25	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	90-95
34562517-6	2021	Furthermore, long-term TA treatment significantly increased the levels of Nrf2 (P<0.001), NQO-1 (P<0.001), and HO-1 (P<0.001) in the hippocampus of the treatment group compared to the UCCAO group.	Tannins	23-25	heme oxygenase 1	Rattus norvegicus	111-115
34562517-10	2021	The cellular mechanism of TA in hypoperfused rats might be associated with the activation of antioxidant pathways, especially the Nrf2 pathway, and suppressing inflammatory factors like NF-kappaB and TNF-alpha.	Tannins	26-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
34562517-10	2021	The cellular mechanism of TA in hypoperfused rats might be associated with the activation of antioxidant pathways, especially the Nrf2 pathway, and suppressing inflammatory factors like NF-kappaB and TNF-alpha.	Tannins	26-28	tumor necrosis factor	Rattus norvegicus	200-209
34858215-7	2021	KCNQ2/3 activation at physiologically relevant, subthreshold membrane potentials by tannic acid, gallic acid and quercetin provided molecular correlates for analgesic action of several of the plants.	Tannins	84-95	potassium voltage-gated channel, subfamily Q, member 2	Mus musculus	0-7
34385012-3	2021	This nanosensor is prepared through the in-situ growth of silver nanoparticles (AgNPs) with the synergetic reduction of tannic acid (TA) and graphene quantum dots (GQDs), which are further decorated with glucose oxidase (GOx).	Tannins	120-131	hydroxyacid oxidase 1	Homo sapiens	204-219
34385012-3	2021	This nanosensor is prepared through the in-situ growth of silver nanoparticles (AgNPs) with the synergetic reduction of tannic acid (TA) and graphene quantum dots (GQDs), which are further decorated with glucose oxidase (GOx).	Tannins	120-131	hydroxyacid oxidase 1	Homo sapiens	221-224
34385012-3	2021	This nanosensor is prepared through the in-situ growth of silver nanoparticles (AgNPs) with the synergetic reduction of tannic acid (TA) and graphene quantum dots (GQDs), which are further decorated with glucose oxidase (GOx).	Tannins	133-135	hydroxyacid oxidase 1	Homo sapiens	204-219
34385012-3	2021	This nanosensor is prepared through the in-situ growth of silver nanoparticles (AgNPs) with the synergetic reduction of tannic acid (TA) and graphene quantum dots (GQDs), which are further decorated with glucose oxidase (GOx).	Tannins	133-135	hydroxyacid oxidase 1	Homo sapiens	221-224
34385012-6	2021	Moreover, the degradation of AgNPs@GQDs-GOx in response to glucose facilitates the cascades-enhanced synergistic therapy of lymph cancer with the combination of starving-like therapy, metal ion therapy and TA-induce apoptosis.	Tannins	206-208	hydroxyacid oxidase 1	Homo sapiens	40-43
34858215-8	2021	While tannic acid also activated KCNQ1 and KCNQ1-KCNE1 at hyperpolarized, negative membrane potentials, it inhibited KCNQ1-KCNE3 at both negative and positive membrane potentials, mechanistically rationalizing historical use of tannic acid-containing plants as gastrointestinal therapeutics.	Tannins	6-17	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	33-38
34858215-8	2021	While tannic acid also activated KCNQ1 and KCNQ1-KCNE1 at hyperpolarized, negative membrane potentials, it inhibited KCNQ1-KCNE3 at both negative and positive membrane potentials, mechanistically rationalizing historical use of tannic acid-containing plants as gastrointestinal therapeutics.	Tannins	6-17	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	43-48
34858215-8	2021	While tannic acid also activated KCNQ1 and KCNQ1-KCNE1 at hyperpolarized, negative membrane potentials, it inhibited KCNQ1-KCNE3 at both negative and positive membrane potentials, mechanistically rationalizing historical use of tannic acid-containing plants as gastrointestinal therapeutics.	Tannins	6-17	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	49-54
34858215-8	2021	While tannic acid also activated KCNQ1 and KCNQ1-KCNE1 at hyperpolarized, negative membrane potentials, it inhibited KCNQ1-KCNE3 at both negative and positive membrane potentials, mechanistically rationalizing historical use of tannic acid-containing plants as gastrointestinal therapeutics.	Tannins	6-17	potassium voltage-gated channel subfamily E regulatory subunit 3	Homo sapiens	123-128
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	186-188	lysozyme	Homo sapiens	189-192
34723563-7	2021	By the addition of NaCl, Tween 20, and urea, we further confirmed that the secondary conformations of Lyz relied greatly on the interactions between TA and Lyz and dominated the growth rate of the multilayers.	Tannins	149-151	lysozyme	Homo sapiens	102-105
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	73-84	lysozyme	Homo sapiens	150-153
34723563-7	2021	By the addition of NaCl, Tween 20, and urea, we further confirmed that the secondary conformations of Lyz relied greatly on the interactions between TA and Lyz and dominated the growth rate of the multilayers.	Tannins	149-151	lysozyme	Homo sapiens	156-159
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	73-84	lysozyme	Homo sapiens	189-192
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	86-88	lysozyme	Homo sapiens	150-153
34564516-2	2021	In this work, tannic acid (TA) and polyethyleneimine (PEI) were grafted on the PES/Fe ultrafiltration membrane via the coordination assembly and Michael addition strategy to fabricated a loose nanofiltration membrane (LNM).	Tannins	14-25	pescadillo ribosomal biogenesis factor 1	Homo sapiens	79-82
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	86-88	lysozyme	Homo sapiens	189-192
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	186-188	lysozyme	Homo sapiens	94-102
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	186-188	lysozyme	Homo sapiens	104-107
34723563-3	2021	Here, we report a layer-by-layer (LbL) multilayer-constructed coating of tannic acid (TA) and lysozyme (Lyz), in which the secondary conformations of Lyz dominate the growth rate of the TA/Lyz coating.	Tannins	186-188	lysozyme	Homo sapiens	150-153
34746569-0	2021	Chitosan-Decorated PLGA-NPs Loaded with Tannic Acid/Vitamin E Mitigate Colon Cancer via the NF-kappaB/beta-Cat/EMT Pathway.	Tannins	40-51	nuclear factor kappa B subunit 1	Homo sapiens	92-101
34746569-0	2021	Chitosan-Decorated PLGA-NPs Loaded with Tannic Acid/Vitamin E Mitigate Colon Cancer via the NF-kappaB/beta-Cat/EMT Pathway.	Tannins	40-51	carboxylesterase 1	Homo sapiens	102-110
34746569-0	2021	Chitosan-Decorated PLGA-NPs Loaded with Tannic Acid/Vitamin E Mitigate Colon Cancer via the NF-kappaB/beta-Cat/EMT Pathway.	Tannins	40-51	IL2 inducible T cell kinase	Homo sapiens	111-114
34679729-5	2021	In contrast, a high concentration of TA (100 mug/mL) significantly decreased the CEI and PTGS1, PTGS2, PTX-3 and HAS2 mRNA expressions in cumulus cells, and reduced oocyte nuclear maturation and the total cell numbers/blastocyst.	Tannins	37-39	prostaglandin-endoperoxide synthase 1	Sus scrofa	89-94
34679729-5	2021	In contrast, a high concentration of TA (100 mug/mL) significantly decreased the CEI and PTGS1, PTGS2, PTX-3 and HAS2 mRNA expressions in cumulus cells, and reduced oocyte nuclear maturation and the total cell numbers/blastocyst.	Tannins	37-39	prostaglandin-endoperoxide synthase 2	Sus scrofa	96-101
34679729-5	2021	In contrast, a high concentration of TA (100 mug/mL) significantly decreased the CEI and PTGS1, PTGS2, PTX-3 and HAS2 mRNA expressions in cumulus cells, and reduced oocyte nuclear maturation and the total cell numbers/blastocyst.	Tannins	37-39	pentraxin 3	Sus scrofa	103-108
34679729-5	2021	In contrast, a high concentration of TA (100 mug/mL) significantly decreased the CEI and PTGS1, PTGS2, PTX-3 and HAS2 mRNA expressions in cumulus cells, and reduced oocyte nuclear maturation and the total cell numbers/blastocyst.	Tannins	37-39	hyaluronan synthase 2	Sus scrofa	113-117
34623753-3	2021	During the intracellular degradation, Fe3+ /Fe2+ conversion mediated by TA can initiate the Fenton reaction to drastically upregulate the reactive oxygen species level in cells, subsequently induce the accumulation of lipid peroxidation, and thereby cause ferroptotic cell death; meanwhile, the released ML210 efficiently represses the activity of GPX4 to activate ferroptosis pathway.	Tannins	72-74	glutathione peroxidase 4	Mus musculus	348-352
34679729-2	2021	The results showed that 10 microg/mL TA significantly improved the cumulus expansion index (CEI), cumulus-expansion-related genes (PTGS1, PTGS2, PTX-3, TNFAIP6 and HAS2) expression and blastocyst formation rates after parthenogenetic activation (PA), in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) compared to the control groups, but not oocyte nuclear maturation.	Tannins	37-39	prostaglandin-endoperoxide synthase 1	Sus scrofa	131-136
34679729-2	2021	The results showed that 10 microg/mL TA significantly improved the cumulus expansion index (CEI), cumulus-expansion-related genes (PTGS1, PTGS2, PTX-3, TNFAIP6 and HAS2) expression and blastocyst formation rates after parthenogenetic activation (PA), in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) compared to the control groups, but not oocyte nuclear maturation.	Tannins	37-39	prostaglandin-endoperoxide synthase 2	Sus scrofa	138-143
34679729-2	2021	The results showed that 10 microg/mL TA significantly improved the cumulus expansion index (CEI), cumulus-expansion-related genes (PTGS1, PTGS2, PTX-3, TNFAIP6 and HAS2) expression and blastocyst formation rates after parthenogenetic activation (PA), in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) compared to the control groups, but not oocyte nuclear maturation.	Tannins	37-39	pentraxin 3	Sus scrofa	145-150
34679729-2	2021	The results showed that 10 microg/mL TA significantly improved the cumulus expansion index (CEI), cumulus-expansion-related genes (PTGS1, PTGS2, PTX-3, TNFAIP6 and HAS2) expression and blastocyst formation rates after parthenogenetic activation (PA), in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) compared to the control groups, but not oocyte nuclear maturation.	Tannins	37-39	TNF alpha induced protein 6	Sus scrofa	152-159
34679729-2	2021	The results showed that 10 microg/mL TA significantly improved the cumulus expansion index (CEI), cumulus-expansion-related genes (PTGS1, PTGS2, PTX-3, TNFAIP6 and HAS2) expression and blastocyst formation rates after parthenogenetic activation (PA), in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) compared to the control groups, but not oocyte nuclear maturation.	Tannins	37-39	hyaluronan synthase 2	Sus scrofa	164-168
34575537-10	2021	In addition, the drug release profile showed more than 80% release, and in the cellular uptake study, the absorption of the formulation (TA-CUR-NSP) containing TA acting as an inhibitor of P-gp was increased by 1.6-fold.	Tannins	160-162	phosphoglycolate phosphatase	Homo sapiens	189-193
34564516-2	2021	In this work, tannic acid (TA) and polyethyleneimine (PEI) were grafted on the PES/Fe ultrafiltration membrane via the coordination assembly and Michael addition strategy to fabricated a loose nanofiltration membrane (LNM).	Tannins	27-29	pescadillo ribosomal biogenesis factor 1	Homo sapiens	79-82
34126339-4	2021	The results revealed that TA treatment significantly decreased OVA-induced AHR, inflammatory cells infiltration, and the expression of various inflammatory mediators (Th2 and Th1 cytokines, eotaxin, and total IgE).	Tannins	26-28	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	63-66
34126339-4	2021	The results revealed that TA treatment significantly decreased OVA-induced AHR, inflammatory cells infiltration, and the expression of various inflammatory mediators (Th2 and Th1 cytokines, eotaxin, and total IgE).	Tannins	26-28	chemokine (C-C motif) ligand 11	Mus musculus	190-197
34126339-5	2021	Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure.	Tannins	14-16	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	64-70
34126339-5	2021	Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure.	Tannins	14-16	mucin 5, subtype B, tracheobronchial	Mus musculus	75-80
34126339-5	2021	Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure.	Tannins	14-16	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	193-196
34126339-6	2021	Furthermore, OVA-induced NF-kappaB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment.	Tannins	142-144	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	13-16
34126339-6	2021	Furthermore, OVA-induced NF-kappaB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment.	Tannins	142-144	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-34
34126339-6	2021	Furthermore, OVA-induced NF-kappaB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment.	Tannins	142-144	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	36-59
34126339-7	2021	In conclusion, TA effectively attenuated AHR, inflammatory response, and airway remodeling in OVA-challenged asthmatic mice.	Tannins	15-17	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	94-97
34253708-7	2021	Pharmacologic (atorvastatin and tannic acid) and genetic (adenoviral overexpression) approaches to augment KLF2 levels attenuated COVID-19-serum-induced increase in endothelial inflammation and monocyte adhesion.	Tannins	32-43	Kruppel like factor 2	Homo sapiens	107-111
34113616-10	2021	Furthermore, syndecan-1 C-terminal domain-expressing BT-549 cells were more proliferative and sensitive to a potent SUMOylation inhibitor, tannic acid, compared with BT-549 cells transfected with an empty expression vector.	Tannins	139-150	syndecan 1	Homo sapiens	13-23
34080663-10	2021	ERS-associated functional proteins, including activating transcription factor 6, protein kinase-like ER kinase, inositol-requiring enzyme 1, spliced X box-binding protein 1 and C/EBP-homologous protein were suppressed in response to TA treatment.	Tannins	233-235	activating transcription factor 6	Rattus norvegicus	46-79
34080663-10	2021	ERS-associated functional proteins, including activating transcription factor 6, protein kinase-like ER kinase, inositol-requiring enzyme 1, spliced X box-binding protein 1 and C/EBP-homologous protein were suppressed in response to TA treatment.	Tannins	233-235	DNA-damage inducible transcript 3	Rattus norvegicus	177-201
34080663-11	2021	Furthermore, the expression levels of ERS-associated apoptotic proteins, including c-Jun N-terminal kinase, Bax, cytochrome c, caspase-3, caspase-12 and caspase-9 were reduced following treatment with TA.	Tannins	201-203	BCL2 associated X, apoptosis regulator	Rattus norvegicus	108-111
34080663-11	2021	Furthermore, the expression levels of ERS-associated apoptotic proteins, including c-Jun N-terminal kinase, Bax, cytochrome c, caspase-3, caspase-12 and caspase-9 were reduced following treatment with TA.	Tannins	201-203	caspase 3	Rattus norvegicus	127-136
34080663-11	2021	Furthermore, the expression levels of ERS-associated apoptotic proteins, including c-Jun N-terminal kinase, Bax, cytochrome c, caspase-3, caspase-12 and caspase-9 were reduced following treatment with TA.	Tannins	201-203	caspase 12	Rattus norvegicus	138-148
34080663-11	2021	Furthermore, the expression levels of ERS-associated apoptotic proteins, including c-Jun N-terminal kinase, Bax, cytochrome c, caspase-3, caspase-12 and caspase-9 were reduced following treatment with TA.	Tannins	201-203	caspase 9	Rattus norvegicus	153-162
34067423-0	2021	Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels.	Tannins	29-40	androgen receptor	Homo sapiens	59-63
34067423-1	2021	This study developed a tannic acid (TA)-supplemented 2-hydroxyethyl methacrylate-co-sulfobetaine methacrylate (HEMA-co-SBMA) nanocomposite hydrogel with mineralization and antibacterial functions.	Tannins	23-34	androgen receptor	Homo sapiens	119-123
34067423-1	2021	This study developed a tannic acid (TA)-supplemented 2-hydroxyethyl methacrylate-co-sulfobetaine methacrylate (HEMA-co-SBMA) nanocomposite hydrogel with mineralization and antibacterial functions.	Tannins	36-38	androgen receptor	Homo sapiens	119-123
35240547-1	2022	Tannic acid (TA)-chitosan (CH) conjugate (TA-g-CH) was prepared using a free radical grafting procedure to increase the antimicrobial and antioxidant performance of CH.	Tannins	0-11	long intergenic non-protein coding RNA 1194	Homo sapiens	42-46
34067030-4	2021	Tyrosinase inhibition assays demonstrated that valonea tannin was 334 times more effective than gallic acid and 3.4 times more effective than tannic acid, which may relate to the larger molecular size.	Tannins	142-153	tyrosinase	Homo sapiens	0-10
35623221-3	2022	The results indicated that the kit had high sensitivity when there was a small amount of DNA (0.0625 ng), more than one male (minor: major=1:19), or a mixture of males and females (male: female=1:32), models of inhibition (250 muM hematin, 1500 ng/muL humic acid and more than 100 ng/muL tannic acid) and degraded samples.	Tannins	288-299	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	31-34
35583462-2	2022	Considering cooperative coordination of a multivalent thiol-pendant polypeptide ligand with iron ions, we put forward a facile strategy for constructing the iron-coordinated nanohybrid of methacryloyloxyethyl phosphorylcholine-grafted polycysteine/iron ions/tannic acid (i.e., PCFT), which could deliver a higher concentration of iron ions into cells.	Tannins	258-269	solute carrier family 46 member 1	Homo sapiens	277-281
35613322-3	2022	Herein, a natural polymer-based conductive hydrogel integrated with favorable mechanical properties, good adhesive performance, and excellent fatigue resistance was fabricated via interpenetrating tannic acid (TA) into a chitosan (CS) cross-linked network in an acidic aqueous solution.	Tannins	197-208	citrate synthase	Homo sapiens	231-233
35613322-4	2022	The hydrogel was composed of a regular hierarchical porous structure, which was built by the hydrogen bonding between TA and CS.	Tannins	118-120	citrate synthase	Homo sapiens	125-127
35240547-1	2022	Tannic acid (TA)-chitosan (CH) conjugate (TA-g-CH) was prepared using a free radical grafting procedure to increase the antimicrobial and antioxidant performance of CH.	Tannins	13-15	long intergenic non-protein coding RNA 1194	Homo sapiens	42-46
35630787-3	2022	In this study, GOx (160 kDa) and HRP (44 kDa) were used in association with tannic acid capped gold NPs (a series with sizes from 7 to 40 nm) to electrodeposit biosensor coatings, sensitive towards glucose and H2O2, respectively.	Tannins	76-87	hydroxyacid oxidase 1	Homo sapiens	15-18
35513212-3	2022	Here, we constructed a self-assembled metal-organic nanomedicine p53/Ce6@ZF-T, which was composed of p53 plasmid-complexed chlorin e6 (Ce6)-poly(amidoamine), Fe2+-containing mesoporous zeolitic imidazolate framework-8 and naturally derived tannic acid (TA).	Tannins	240-251	tumor protein p53	Homo sapiens	65-68
35513212-3	2022	Here, we constructed a self-assembled metal-organic nanomedicine p53/Ce6@ZF-T, which was composed of p53 plasmid-complexed chlorin e6 (Ce6)-poly(amidoamine), Fe2+-containing mesoporous zeolitic imidazolate framework-8 and naturally derived tannic acid (TA).	Tannins	240-251	tumor protein p53	Homo sapiens	101-104
35513212-3	2022	Here, we constructed a self-assembled metal-organic nanomedicine p53/Ce6@ZF-T, which was composed of p53 plasmid-complexed chlorin e6 (Ce6)-poly(amidoamine), Fe2+-containing mesoporous zeolitic imidazolate framework-8 and naturally derived tannic acid (TA).	Tannins	253-255	tumor protein p53	Homo sapiens	65-68
35513212-3	2022	Here, we constructed a self-assembled metal-organic nanomedicine p53/Ce6@ZF-T, which was composed of p53 plasmid-complexed chlorin e6 (Ce6)-poly(amidoamine), Fe2+-containing mesoporous zeolitic imidazolate framework-8 and naturally derived tannic acid (TA).	Tannins	253-255	tumor protein p53	Homo sapiens	101-104
35513212-4	2022	The highly cytotoxic ROS was continuously produced via Fe2+-mediated and TA-assisted enhanced Fenton reaction as well as Ce6-induced photosensitive reaction, and meanwhile, the intratumoral upregulated p53 expression inactivated glutathione peroxidase 4 (GPX4) to suppress lipid peroxidation (LPO) resistance, thus resulting in amplified oxidative stress and intensified ferroptosis-apoptosis therapy.	Tannins	73-75	tumor protein p53	Homo sapiens	202-205
35513212-4	2022	The highly cytotoxic ROS was continuously produced via Fe2+-mediated and TA-assisted enhanced Fenton reaction as well as Ce6-induced photosensitive reaction, and meanwhile, the intratumoral upregulated p53 expression inactivated glutathione peroxidase 4 (GPX4) to suppress lipid peroxidation (LPO) resistance, thus resulting in amplified oxidative stress and intensified ferroptosis-apoptosis therapy.	Tannins	73-75	glutathione peroxidase 4	Homo sapiens	229-253
35513212-4	2022	The highly cytotoxic ROS was continuously produced via Fe2+-mediated and TA-assisted enhanced Fenton reaction as well as Ce6-induced photosensitive reaction, and meanwhile, the intratumoral upregulated p53 expression inactivated glutathione peroxidase 4 (GPX4) to suppress lipid peroxidation (LPO) resistance, thus resulting in amplified oxidative stress and intensified ferroptosis-apoptosis therapy.	Tannins	73-75	glutathione peroxidase 4	Homo sapiens	255-259
35571952-8	2022	Also, TA inhibited the secretion of serum hormones (cortisol (COR), glucocorticoid (GC), and adrenocorticotropic hormone (ACTH)) and the expression of heat shock protein (HSP) 70 to protect dogs from stress-induced injury, thereby relieving oxidative stress and inflammatory response.	Tannins	6-8	proopiomelanocortin	Canis lupus familiaris	93-120
35571952-8	2022	Also, TA inhibited the secretion of serum hormones (cortisol (COR), glucocorticoid (GC), and adrenocorticotropic hormone (ACTH)) and the expression of heat shock protein (HSP) 70 to protect dogs from stress-induced injury, thereby relieving oxidative stress and inflammatory response.	Tannins	6-8	proopiomelanocortin	Canis lupus familiaris	122-126
35571952-8	2022	Also, TA inhibited the secretion of serum hormones (cortisol (COR), glucocorticoid (GC), and adrenocorticotropic hormone (ACTH)) and the expression of heat shock protein (HSP) 70 to protect dogs from stress-induced injury, thereby relieving oxidative stress and inflammatory response.	Tannins	6-8	heat shock 70 kDa protein 1	Canis lupus familiaris	151-178
35128765-8	2022	Further, two naturally occurring antioxidants, tannic acid and ascorbic acid showed inhibitory effect on the peroxidase like activity of AuNRTs in a concentration dependent manner which can be further be used for screening of antioxidants or for determining the antioxidant potential.	Tannins	47-58	peroxidase E5-like	Raphanus sativus	109-119
35453457-7	2022	Circular dichroism (CD) observed the structural variation in the tyrosinase after reacting with the tannins.	Tannins	100-107	tyrosinase	Mus musculus	65-75
35426140-1	2022	BACKGROUND: For decades, pine nut oil Pickering emulsions have been stabilized using a covalent composite of two phenolic chemicals (tannic acid and gallic acid) and whey protein isolate following alkali treatment.	Tannins	133-144	NUT midline carcinoma family member 1	Homo sapiens	30-33
35409304-0	2022	Co-Application with Tannic Acid Prevents Transdermal Sensitization to Ovalbumin in Mice.	Tannins	20-31	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	70-79
35409304-6	2022	The results showed that the co-application with TA prevents transdermal sensitization to OVA.	Tannins	48-50	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	89-92
35424669-1	2022	Herein, gadolinium tannate was simply and conveniently coated on the surface of palygorskite by in situ reaction of a coordination polymer formed between tannic acid and Gd3+.	Tannins	154-165	GRDX	Homo sapiens	170-173
35352127-9	2022	The TA decreased plasma malondialdehyde concentration, and increased plasma T-SOD, GSH-Px, total antioxidant capacity, and hepatic GST activity compared to the AF (P < 0.05).	Tannins	4-6	glutathione S-transferase kappa 1	Homo sapiens	131-134
35367430-2	2022	However, these large-scale tap water sources are oftentimes abundant with dissolved natural organic matter (NOM), such as tannic acid issue causing color in water.	Tannins	122-133	nuclear RNA export factor 1	Homo sapiens	27-30
35382280-0	2022	Tuning the Energetic Performance of CL-20 by Surface Modification Using Tannic Acid and Energetic Coordination Polymers.	Tannins	72-83	epithelial membrane protein 1	Homo sapiens	36-41
35382280-2	2022	First, tannic acid polymerized in situ on the surface of CL-20 crystals.	Tannins	7-18	epithelial membrane protein 1	Homo sapiens	57-62
35167630-2	2022	Herein, a physicochemically double-network crosslinked hydrogel matrix was prepared by mixing acrylic acid (AAc), chitosan (CS) and tannic acid (TA) as the main components and the subsequent in situ polymerization of AAc.	Tannins	132-143	glycine-N-acyltransferase	Homo sapiens	217-220
35167630-2	2022	Herein, a physicochemically double-network crosslinked hydrogel matrix was prepared by mixing acrylic acid (AAc), chitosan (CS) and tannic acid (TA) as the main components and the subsequent in situ polymerization of AAc.	Tannins	145-147	glycine-N-acyltransferase	Homo sapiens	217-220
31595805-0	2022	Effects of tannic acid in streptozotocin-induced sporadic Alzheimer"s Disease: insights into memory, redox status, Na+, K+-ATPase and acetylcholinesterase activity.	Tannins	11-22	acetylcholinesterase	Rattus norvegicus	134-154
35269785-6	2022	In this work, a combination of experimental methods (biochemical inhibition assays, surface plasmon resonance, and quartz crystal microbalance with dissipation monitoring) confirms the potential role of TA in the prevention of SARS-CoV-2 infectivity through the inhibition of extracellular RBD/ACE2 interactions and TMPRSS2 and 3CLpro activity.	Tannins	203-205	angiotensin converting enzyme 2	Homo sapiens	294-298
35269785-6	2022	In this work, a combination of experimental methods (biochemical inhibition assays, surface plasmon resonance, and quartz crystal microbalance with dissipation monitoring) confirms the potential role of TA in the prevention of SARS-CoV-2 infectivity through the inhibition of extracellular RBD/ACE2 interactions and TMPRSS2 and 3CLpro activity.	Tannins	203-205	transmembrane serine protease 2	Homo sapiens	316-323
35104489-7	2022	Nutraceuticals belonging to the chemical category polyphenols, alkaloids, terpenoids, flavonoids, tannins have the potential to combat the NF-kappaB pathway.	Tannins	98-105	nuclear factor kappa B subunit 1	Homo sapiens	139-148
35161041-2	2022	Herein, DOX is loaded into iron-rich metal-organic framework/tannic acid (TA) nanocomplex to form a tumor-targeting and acid-activatable drug delivery system (MOF/TA-DOX, MTD).	Tannins	61-72	metallothionein 1E	Homo sapiens	171-174
35056766-10	2022	CONCLUSION: Combination treatment of TA and PAM at 75:25 ameliorated the highest enhancement of osteoblast proliferation and mineralization as well as caused a high expression of BSP and Osx genes.	Tannins	37-39	integrin binding sialoprotein	Homo sapiens	179-182
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	64-75	coagulation factor II, thrombin	Homo sapiens	2-10
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	64-75	plasminogen activator, urokinase	Homo sapiens	95-112
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	64-75	plasminogen activator, urokinase	Homo sapiens	114-117
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	64-75	coagulation factor II, thrombin	Homo sapiens	125-133
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	77-79	coagulation factor II, thrombin	Homo sapiens	2-10
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	77-79	plasminogen activator, urokinase	Homo sapiens	95-112
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	77-79	plasminogen activator, urokinase	Homo sapiens	114-117
35019268-5	2022	A thrombin-dependent drug release mechanism is integrated using tannic acid (TA) to cross-link urokinase-type PA (uPA) and a thrombin-cleavable peptide on a sacrificial mesoporous silica template via noncovalent interactions.	Tannins	77-79	coagulation factor II, thrombin	Homo sapiens	125-133
35023715-2	2022	Herein, we report the facile construction of a multifunctional theranostic nanoplatform based on doxorubicin (DOX)-loaded tannic acid (TA)-iron (Fe) networks (for short, TAF) coated with fibronectin (FN) for combination tumor chemo-/chemodynamic/immune therapy under the guidance of magnetic resonance (MR) imaging.	Tannins	122-133	fibronectin 1	Homo sapiens	187-198
35023715-2	2022	Herein, we report the facile construction of a multifunctional theranostic nanoplatform based on doxorubicin (DOX)-loaded tannic acid (TA)-iron (Fe) networks (for short, TAF) coated with fibronectin (FN) for combination tumor chemo-/chemodynamic/immune therapy under the guidance of magnetic resonance (MR) imaging.	Tannins	135-137	fibronectin 1	Homo sapiens	187-198
35013421-8	2022	The robustness of our screening method was validated by a primary neuronal cell model and a Caenorhabditis elegans model, which demonstrated the effect of tannic acid against alpha-synuclein aggregation.	Tannins	155-166	synuclein alpha	Homo sapiens	175-190
35013421-9	2022	In conclusion, our two-step screening system is a powerful method for the identification of alpha-synuclein aggregation inhibitors, and tannic acid is a promising candidate as a disease-modifying drug for Parkinson"s disease.	Tannins	136-147	synuclein alpha	Homo sapiens	92-107
35544363-14	2022	Furthermore, treatment with TA significantly improved KA-induced pyramidal cell loss and change in the arrangement of CA1 molecular layer.	Tannins	28-30	carbonic anhydrase 1	Mus musculus	118-121