PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9183003-0	1997	Inhibition of human placenta glutathione transferase P1-1 by the antibiotic calvatic acid and its diazocyanide analogue--evidence for multiple catalytic intermediates.	calvatic acid	76-89	S100 calcium binding protein A10	Homo sapiens	53-57
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	93-106	glutathione S-transferase pi 1	Homo sapiens	80-87
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	93-106	glutathione S-transferase pi 1	Homo sapiens	301-309
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	93-106	glutathione S-transferase pi 1	Homo sapiens	362-370
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	173-186	glutathione S-transferase pi 1	Homo sapiens	80-87
9183003-1	1997	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST) P1-1 by calvatic acid and the reaction intermediates, i.e. the diazocyanide analogue of calvatic acid, has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different molar ratios of inhibitor/GST P1-1 indicate that 1 mol calvatic acid inactivates 1 mol GST P1-1, containing two catalytically equivalent active sites.	calvatic acid	173-186	glutathione S-transferase pi 1	Homo sapiens	80-87
9183003-2	1997	However, 2 mol of the diazocyanide analogue of calvatic acid inactivate 1 mol GST P1-1.	calvatic acid	47-60	glutathione S-transferase pi 1	Homo sapiens	78-86
9183003-3	1997	Two disulfide bridges/dimer, probably between Cys47 and Cys101, have been formed during the reaction of GST P1-1 with calvatic acid and its diazocyanide analogue.	calvatic acid	118-131	glutathione S-transferase pi 1	Homo sapiens	104-110
9183003-4	1997	The apparent second-order rate constants for GST P1-1 inactivation by calvatic acid and its diazocyanide analogue are 2.4+/-0.3 M(-1) s(-1) and (8.5+/-0.7) x 10(3) M(-1) s(-1), respectively.	calvatic acid	70-83	glutathione S-transferase pi 1	Homo sapiens	45-53
8069231-0	1994	Inhibition of human placenta glutathione transferase P1-1 by calvatic acid.	calvatic acid	61-74	S100 calcium binding protein A10	Homo sapiens	53-57
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	137-150	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	137-150	glutathione S-transferase pi 1	Homo sapiens	253-261
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	239-252	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-1	1994	The inhibition mechanism of the dimeric human placenta glutathione transferase (GST P1-1) by the antibiotic p-carboxyphenylazoxycyanide (calvatic acid) has been investigated at pH 7.0 and 30.0 degrees C. Experiments performed at different calvatic acid/GST P1-1 molar ratios indicate that one mole of calvatic acid inactivates one mole of the homodimeric enzyme molecule, containing two catalytically equivalent active sites.	calvatic acid	239-252	glutathione S-transferase pi 1	Homo sapiens	80-88
8069231-3	1994	The recovery of all the 5,5"-dithio-bis(2-nitro-benzoic acid)-titratable thiol groups as well as the original catalytic activity of GST P1-1 after treatment of the inhibited enzyme with dithiothreitol indicates that two disulfide bridges per dimer, likely between Cys47 and Cys101, have been formed during the reaction with calvatic acid.	calvatic acid	324-337	glutathione S-transferase pi 1	Homo sapiens	132-140
2277863-0	1990	Effect of calvatic acid and its analogs on ornithine decarboxylase activity in tumour cells.	calvatic acid	10-23	ornithine decarboxylase 1	Homo sapiens	43-66