PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2556506-0 1989 Cross-communication between acetylcholine and VIP in controlling catecholamine secretion by affecting cAMP, inositol triphosphate, protein kinase C, and calcium in rat adrenal medulla. Catecholamines 65-78 vasoactive intestinal peptide Rattus norvegicus 46-49 2597437-0 1989 Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation. Catecholamines 15-28 ornithine transcarbamylase Mus musculus 64-90 2573510-0 1989 In the rat, interleukin-1 alpha and -beta stimulate adrenocorticotropin and catecholamine release. Catecholamines 76-89 interleukin 1 alpha Rattus norvegicus 12-41 2573510-1 1989 Recombinant interleukin-1 alpha and -beta (Il-1 alpha and -beta) have been evaluated for their abilities to stimulate ACTH and catecholamine secretion in the intact adult male rat. Catecholamines 127-140 interleukin 1 alpha Rattus norvegicus 12-41 2573510-1 1989 Recombinant interleukin-1 alpha and -beta (Il-1 alpha and -beta) have been evaluated for their abilities to stimulate ACTH and catecholamine secretion in the intact adult male rat. Catecholamines 127-140 interleukin 1 alpha Rattus norvegicus 43-63 2573510-9 1989 These results suggest that both Il-1 alpha and Il-1 beta stimulate ACTH and catecholamine secretion in the rat. Catecholamines 76-89 interleukin 1 alpha Rattus norvegicus 32-42 2573510-9 1989 These results suggest that both Il-1 alpha and Il-1 beta stimulate ACTH and catecholamine secretion in the rat. Catecholamines 76-89 interleukin 1 beta Rattus norvegicus 47-56 2561150-1 1989 The regulation of platelet alpha 2- and lymphocyte beta 2-adrenoceptor densities by alterations in endogenous catecholamines was examined. Catecholamines 110-124 adrenoceptor beta 2 Homo sapiens 51-70 2572679-1 1989 The effect of induction of adrenal tyrosine hydroxylase (TH) by various centrally acting drugs on catecholamine levels in adrenal and plasma was investigated in rats. Catecholamines 98-111 tyrosine hydroxylase Rattus norvegicus 35-55 2572679-1 1989 The effect of induction of adrenal tyrosine hydroxylase (TH) by various centrally acting drugs on catecholamine levels in adrenal and plasma was investigated in rats. Catecholamines 98-111 tyrosine hydroxylase Rattus norvegicus 57-59 2572679-4 1989 The results suggest that the induced increase of adrenal TH activity, as mediated by certain drugs, results in an elevation of the plasma epinephrine level and that the adrenal dopamine content is a better indicator of the catecholamine-synthesizing capacity of the adrenal medulla than are the other catecholamines. Catecholamines 223-236 tyrosine hydroxylase Rattus norvegicus 57-59 2572679-4 1989 The results suggest that the induced increase of adrenal TH activity, as mediated by certain drugs, results in an elevation of the plasma epinephrine level and that the adrenal dopamine content is a better indicator of the catecholamine-synthesizing capacity of the adrenal medulla than are the other catecholamines. Catecholamines 301-315 tyrosine hydroxylase Rattus norvegicus 57-59 2481449-1 1989 The myosin-light-chain (MLC) phosphorylation accompanying catecholamine release in chromaffin cells was investigated with the objective of assessing the possible role of this contractile protein in catecholamine secretion. Catecholamines 58-71 modulator of VRAC current 1 Homo sapiens 4-22 2481449-1 1989 The myosin-light-chain (MLC) phosphorylation accompanying catecholamine release in chromaffin cells was investigated with the objective of assessing the possible role of this contractile protein in catecholamine secretion. Catecholamines 58-71 modulator of VRAC current 1 Homo sapiens 24-27 2481449-5 1989 Cell stimulation by secretagogues resulted in a Ca2(+)-dependent 32P incorporation into MLC, the time course of this process being related to catecholamine release. Catecholamines 142-155 modulator of VRAC current 1 Homo sapiens 88-91 2557227-15 1989 Catecholamines may be one of the physiologic regulators of the c-fos gene. Catecholamines 0-14 FBJ osteosarcoma oncogene Mus musculus 63-68 2481782-5 1989 The inhibitory cardiac effects of NPY are likely to be secondary to coronary vasoconstriction, presynaptic inhibition of catecholamine release, and/or baroreflex activity. Catecholamines 121-134 neuropeptide Y Homo sapiens 34-37 2574197-0 1989 Catecholamine-containing neurons in the sheep brainstem and diencephalon: immunohistochemical study with tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) antibodies. Catecholamines 0-13 tyrosine 3-monooxygenase Ovis aries 105-125 2574197-0 1989 Catecholamine-containing neurons in the sheep brainstem and diencephalon: immunohistochemical study with tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) antibodies. Catecholamines 0-13 dopamine beta-hydroxylase (dopamine beta-monooxygenase) Ovis aries 135-160 2574197-0 1989 Catecholamine-containing neurons in the sheep brainstem and diencephalon: immunohistochemical study with tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) antibodies. Catecholamines 0-13 dopamine beta-hydroxylase (dopamine beta-monooxygenase) Ovis aries 162-165 2574197-1 1989 The present study describes the distribution and morphological characteristics of neurons and nerve fibers containing the catecholamine-synthesizing enzymes, tyrosine hydroxylase and dopamine-beta-hydroxylase, in the sheep brainstem and diencephalon on the basis of immunohistochemical procedures. Catecholamines 122-135 tyrosine 3-monooxygenase Ovis aries 158-178 2575177-7 1989 It has been shown in our laboratory that the activity of the LDL receptor of peripheral cells, a major determinant of cholesterol levels in plasma, is regulated by catecholamines via alpha 2- and beta 2-adrenergic receptors. Catecholamines 164-178 low density lipoprotein receptor Homo sapiens 61-73 2633017-13 1989 The results showed that the plasma NPY was significantly decreased under high dose fentanyl as well as catecholamines. Catecholamines 103-117 neuropeptide Y Homo sapiens 35-38 2512584-5 1989 The results suggest that intraventricular injection of colchicine is a stressful stimulus and support the view that several catecholamine cell groups in the lower brainstem are part of the brain circuitry mediating stress reactions, as are the hypothalamic neurons that contain corticotropin-releasing factor. Catecholamines 124-137 corticotropin releasing hormone Rattus norvegicus 278-308 2512185-5 1989 Consecutive intrathecal administration of TRH for 6 days enhanced cerebral catecholamine content. Catecholamines 75-88 thyrotropin releasing hormone Rattus norvegicus 42-45 2512185-6 1989 These results indicate that (1) TRH accelerates metabolic rate of catecholamine in the central nervous system as well as peripheral tissues, and (2) TRH acts on both noradrenergic and dopaminergic neurons in cerebral hemisphere, diencephalon and midbrain, whereas cyclo(His-Pro) acts mainly on dopaminergic neurons in cerebellum, pons and medulla oblongata. Catecholamines 66-79 thyrotropin releasing hormone Rattus norvegicus 32-35 2512185-0 1989 [Effect of TRH and histidyl-proline diketopiperazine (cyclo(His-Pro] on catecholamine secretion]. Catecholamines 72-85 thyrotropin releasing hormone Rattus norvegicus 11-14 2573869-1 1989 A population of neurons situated in the human cerebral neocortex contains mRNA coding for tyrosine hydroxylase, the key enzyme for catecholamine biosynthesis. Catecholamines 131-144 tyrosine hydroxylase Homo sapiens 90-110 2560726-0 1989 Beta-adrenoceptors desensitization may modulate catecholamine induced insulin resistance in human pheochromocytoma. Catecholamines 48-61 insulin Homo sapiens 70-77 2688232-5 1989 Thus, smoking stimulates the secretion of the antiinsulin hormones, particularly catecholamines, resulting in subcutaneous vasoconstriction which may be unfortunate as it influences insulin absorption. Catecholamines 81-95 insulin Homo sapiens 50-57 2512185-1 1989 The effects of TRH and its metabolite, histidyl-proline diketopiperazine (cyclo(His-Pro] on catecholamine metabolism in the central nervous system, peripheral tissues and plasma were examined in adult and young Wistar rats aged 3 weeks. Catecholamines 92-105 thyrotropin releasing hormone Rattus norvegicus 15-18 2512185-4 1989 After intraperitoneal injection of 3 mg of alpha-methyl-p-tyrosine, which blocked re-uptake of catecholamines in synapses, intrathecal administration of 30 ng TRH accelerated 2 times metabolic turnover of norepinephrine and dopamine in cerebral hemisphere, diencephalon and midbrain as well as norepinephrine turnover in cerebellum, pons, medulla oblongata, heart and brown adipose tissue. Catecholamines 95-109 thyrotropin releasing hormone Rattus norvegicus 159-162 2560726-1 1989 Catecholamines acutely exert a pronounced insulin-antagonistic effect, which is mediated by beta-adrenergic receptors stimulation. Catecholamines 0-14 insulin Homo sapiens 42-49 2556154-4 1989 Similar treatment of cyc- S49 cells, a mutant that lacks Gs, resulted in only a 10-15% receptor loss despite a 50% decrease in catecholamine stimulation of reconstituted adenylyl cyclase activity. Catecholamines 127-140 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 21-24 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 137-140 2614337-1 1989 This study tests the hypothesis that catecholamines regulate glucose availability during hypoxia in the rainbow trout by activating glycogen phosphorylase (GPase) while inhibiting pyruvate kinase (PK) in the liver. Catecholamines 37-51 pyruvate kinase PKM Oncorhynchus mykiss 180-195 2614337-1 1989 This study tests the hypothesis that catecholamines regulate glucose availability during hypoxia in the rainbow trout by activating glycogen phosphorylase (GPase) while inhibiting pyruvate kinase (PK) in the liver. Catecholamines 37-51 pyruvate kinase PKM Oncorhynchus mykiss 197-199 2614337-9 1989 The specific metabolic consequences of these catecholamine-mediated effects are an increase in the activity of the active form of GPase and a reduction in PK activity, which suggests an activation of glycogenolysis and an inhibition of glycolysis and/or activation of gluconeogenesis, respectively. Catecholamines 45-58 pyruvate kinase PKM Oncorhynchus mykiss 155-157 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 tyrosine hydroxylase Rattus norvegicus 83-103 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 110-135 2575695-3 1989 To further investigate the effects of stress on the expression of the catecholamine biosynthetic enzymes, we have isolated a rat cDNA clone encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT). Catecholamines 70-83 phenylethanolamine-N-methyltransferase Rattus norvegicus 185-223 2575695-3 1989 To further investigate the effects of stress on the expression of the catecholamine biosynthetic enzymes, we have isolated a rat cDNA clone encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT). Catecholamines 70-83 phenylethanolamine-N-methyltransferase Rattus norvegicus 225-229 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 phenylethanolamine-N-methyltransferase Rattus norvegicus 146-184 2622800-3 1989 Antibodies to CRF, ACTH(1-39) and the catecholamine synthesizing enzymes which are tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) were utilized. Catecholamines 38-51 phenylethanolamine-N-methyltransferase Rattus norvegicus 186-190 2509073-4 1989 These findings indicate that catecholamine-containing neurons innervate GRF neurons to regulate GRF secretion via synapses in the rat arcuate nucleus. Catecholamines 29-42 growth hormone releasing hormone Rattus norvegicus 72-75 2553215-0 1989 Atrial natriuretic polypeptide attenuates central angiotensin II-induced catecholamine and ACTH secretion. Catecholamines 73-86 angiotensinogen Rattus norvegicus 50-64 2801921-0 1989 Regulation of angiotensin II binding sites in neuronal cultures by catecholamines. Catecholamines 67-81 angiotensinogen Rattus norvegicus 14-28 2509073-4 1989 These findings indicate that catecholamine-containing neurons innervate GRF neurons to regulate GRF secretion via synapses in the rat arcuate nucleus. Catecholamines 29-42 growth hormone releasing hormone Rattus norvegicus 96-99 2793216-1 1989 Chromogranin A (CgA) is the major soluble protein in catecholamine storage vesicles. Catecholamines 53-66 chromogranin A Rattus norvegicus 0-14 2515113-7 1989 The possibility that the Tcr and l(2)amd mutations reveal a catecholamine metabolic pathway involved in cuticle structure is discussed. Catecholamines 60-73 Tcr Drosophila melanogaster 25-28 2507469-13 1989 Thus, the IOP elevation following TRH administration probably is caused by the increase of circulating endogenous catecholamines and not by the stimulation of the TSH-thyroid hormone axis. Catecholamines 114-128 thyrotropin releasing hormone Oryctolagus cuniculus 34-37 2793216-1 1989 Chromogranin A (CgA) is the major soluble protein in catecholamine storage vesicles. Catecholamines 53-66 chromogranin A Rattus norvegicus 16-19 2813383-0 1989 Molecular cloning and sequencing of a cDNA of rat dopa decarboxylase: partial amino acid homologies with other enzymes synthesizing catecholamines. Catecholamines 132-146 dopa decarboxylase Rattus norvegicus 50-68 2812275-2 1989 Neuropeptide Y (NPY) is colocalized with catecholamines in brainstem-hypothalamus neuronal pathways implicated in the regulation of the hypothalamo-hypophyso-adrenocortical system (HHAS) and may interact with catecholamines in the regulation of neuroendocrine stress responses. Catecholamines 41-55 neuropeptide Y Homo sapiens 0-14 2812275-2 1989 Neuropeptide Y (NPY) is colocalized with catecholamines in brainstem-hypothalamus neuronal pathways implicated in the regulation of the hypothalamo-hypophyso-adrenocortical system (HHAS) and may interact with catecholamines in the regulation of neuroendocrine stress responses. Catecholamines 41-55 neuropeptide Y Homo sapiens 16-19 2812275-2 1989 Neuropeptide Y (NPY) is colocalized with catecholamines in brainstem-hypothalamus neuronal pathways implicated in the regulation of the hypothalamo-hypophyso-adrenocortical system (HHAS) and may interact with catecholamines in the regulation of neuroendocrine stress responses. Catecholamines 209-223 neuropeptide Y Homo sapiens 0-14 2813383-6 1989 A sequence of 58 amino acid residues, including this repeating structure of rat DDC, was found to show homologies with those of rat tyrosine hydroxylase, human dopamine beta-hydroxylase, and bovine phenylethanolamine N-methyltransferase, other mammalian enzymes that synthesize catecholamines. Catecholamines 278-292 dopa decarboxylase Rattus norvegicus 80-83 2812275-2 1989 Neuropeptide Y (NPY) is colocalized with catecholamines in brainstem-hypothalamus neuronal pathways implicated in the regulation of the hypothalamo-hypophyso-adrenocortical system (HHAS) and may interact with catecholamines in the regulation of neuroendocrine stress responses. Catecholamines 209-223 neuropeptide Y Homo sapiens 16-19 2481734-18 1989 The responses of PGE, oxytocin and ANF thus resembled currents elicited by catecholamines, adenosine, gonadotrophins and vasoactive intestinal peptide (VIP). Catecholamines 75-89 natriuretic peptide A L homeolog Xenopus laevis 35-38 2575455-2 1989 Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis, and it is a pterin-requiring monooxygenase. Catecholamines 56-69 tyrosine hydroxylase Homo sapiens 0-20 2575455-2 1989 Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis, and it is a pterin-requiring monooxygenase. Catecholamines 56-69 tyrosine hydroxylase Homo sapiens 22-24 2569506-2 1989 Both cell cultures contain adenylate cyclase stimulated by catecholamines with a potency order of isoprenaline greater than adrenaline greater than salbutamol much greater than noradrenaline, which is consistent with the presence of beta 2-adrenergic receptors. Catecholamines 59-73 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 233-239 2788491-0 1989 Interleukin-2 enhances biopterins and catecholamines production during adoptive immunotherapy for various cancers. Catecholamines 38-52 interleukin 2 Homo sapiens 0-13 2788491-9 1989 Increased biopterins production was also associated with increase in plasma catecholamine after IL-2 treatment during adoptive immunotherapy. Catecholamines 76-89 interleukin 2 Homo sapiens 96-100 2789663-4 1989 Although chromogranin A is coreleased with catecholamines from the sympathoadrenomedullary system, it does not respond to modest short-term postural or psychological stimuli that simultaneously evoke changes in other variables relevant to the sympathetic nervous system. Catecholamines 43-57 chromogranin A Homo sapiens 9-23 2555817-1 1989 The role of catechol-o-methyltransferase (COMT) in functional interrelationship between testosterone (T), catechol estrogens (CE) and catecholamines (CA) during cerebral sex differentiation (CSD) was investigated in experiments on Wistar rats. Catecholamines 134-148 catechol-O-methyltransferase Rattus norvegicus 12-40 2555817-1 1989 The role of catechol-o-methyltransferase (COMT) in functional interrelationship between testosterone (T), catechol estrogens (CE) and catecholamines (CA) during cerebral sex differentiation (CSD) was investigated in experiments on Wistar rats. Catecholamines 134-148 catechol-O-methyltransferase Rattus norvegicus 42-46 2776842-0 1989 Neuropeptide Y (NPY): a coronary vasoconstrictor and potentiator of catecholamine-induced coronary constriction. Catecholamines 68-81 neuropeptide Y Canis lupus familiaris 0-14 2764985-0 1989 Myosin light-chain kinase inhibitor, 1-(5-chlornaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9), inhibits catecholamine secretion from adrenal chromaffin cells by inhibiting Ca2+ uptake into the cells. Catecholamines 115-128 myosin light chain kinase, smooth muscle Bos taurus 0-25 2569916-0 1989 Direct synaptic contacts of catecholamine fibers on neuropeptide Y-containing neurons of the rat cerebral cortex. Catecholamines 28-41 neuropeptide Y Rattus norvegicus 52-66 2569916-1 1989 A direct synapse between catecholamine (CA) fibers and neuropeptide Y (NPY)-containing neurons was demonstrated in rat cerebral cortex by using an immunohistochemical double-staining method under electron microscopy. Catecholamines 25-38 neuropeptide Y Rattus norvegicus 55-69 2569916-1 1989 A direct synapse between catecholamine (CA) fibers and neuropeptide Y (NPY)-containing neurons was demonstrated in rat cerebral cortex by using an immunohistochemical double-staining method under electron microscopy. Catecholamines 25-38 neuropeptide Y Rattus norvegicus 71-74 2776842-0 1989 Neuropeptide Y (NPY): a coronary vasoconstrictor and potentiator of catecholamine-induced coronary constriction. Catecholamines 68-81 neuropeptide Y Canis lupus familiaris 16-19 2776842-7 1989 These results show that NPY is a potent coronary vasoconstrictor and a potentiator of the contractile effect of catecholamines and support the hypothesis that NPY may participate in the regulation of coronary vascular resistance. Catecholamines 112-126 neuropeptide Y Canis lupus familiaris 24-27 2547929-1 1989 This study tests the hypothesis that atrial natriuretic factor (ANF) inhibits catecholamine release from rat pheochromocytoma cells by increasing levels of intracellular cyclic GMP (cGMP). Catecholamines 78-91 natriuretic peptide A Rattus norvegicus 37-62 2752969-1 1989 The present study was an attempt to assess the inhibitory effect of methionine-enkephalin (Met-Enk) on adrenal catecholamine release under in vivo conditions employing a microdialysis system. Catecholamines 111-124 proenkephalin Rattus norvegicus 95-98 2752969-13 1989 We demonstrate in vivo a paracrine or autocrine action of Met-Enk on Ach-stimulated catecholamine release by applying the peptide directly into the adrenal gland via a microdialysis system. Catecholamines 84-97 proenkephalin Rattus norvegicus 62-65 2547929-1 1989 This study tests the hypothesis that atrial natriuretic factor (ANF) inhibits catecholamine release from rat pheochromocytoma cells by increasing levels of intracellular cyclic GMP (cGMP). Catecholamines 78-91 natriuretic peptide A Rattus norvegicus 64-67 2478746-5 1989 After discontinuation of allapinine, the changes in beta 2-adrenoreceptor density and affinity for catecholamines remained on days 3 and 7, respectively. Catecholamines 99-113 adrenoceptor beta 2 Homo sapiens 52-73 2526588-14 1989 Earlier (24 h) catecholamine depletion of rats with 100 mg/kg 6-hydroxydopamine also significantly reduced peak hypoxia-induced ANF release to 330%. Catecholamines 15-28 natriuretic peptide A Rattus norvegicus 128-131 2568894-1 1989 An antibody to tyrosine hydroxylase (TH), the rate-limiting enzyme in the production of catecholamines, was used to examine the morphology and distribution of catecholaminergic neurons in whole-mounted retinae of the developing and adult mouse. Catecholamines 88-102 tyrosine hydroxylase Mus musculus 15-35 2723655-7 1989 When the cells were treated with p-chloromercuribenzoate, dopamine-beta-hydroxylase, an enzyme present in the chromaffin granules along with catecholamines, was also released. Catecholamines 141-155 dopamine beta-hydroxylase Bos taurus 58-83 2569914-9 1989 Dual labeling for the beta AR-antibody by the immunoperoxidase method and for a rabbit antiserum against the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), by the immunoautoradiographic method within the same sections, further established the precise cellular relations between beta AR and catecholaminergic neurons. Catecholamines 109-122 tyrosine hydroxylase Rattus norvegicus 144-164 2526581-1 1989 The authors studied the effect of intravenous infusion of atrial natriuretic peptide (ANP) on the plasma catecholamine and forearm vasoconstrictor responses to cardiopulmonary baroreflex deactivation in six normal, male volunteers in order to determine whether ANP influences reflex forearm vasoconstriction in humans. Catecholamines 105-118 natriuretic peptide A Homo sapiens 58-84 2526581-1 1989 The authors studied the effect of intravenous infusion of atrial natriuretic peptide (ANP) on the plasma catecholamine and forearm vasoconstrictor responses to cardiopulmonary baroreflex deactivation in six normal, male volunteers in order to determine whether ANP influences reflex forearm vasoconstriction in humans. Catecholamines 105-118 natriuretic peptide A Homo sapiens 86-89 2568894-1 1989 An antibody to tyrosine hydroxylase (TH), the rate-limiting enzyme in the production of catecholamines, was used to examine the morphology and distribution of catecholaminergic neurons in whole-mounted retinae of the developing and adult mouse. Catecholamines 88-102 tyrosine hydroxylase Mus musculus 37-39 2570800-2 1989 GAD immunoreactivity was analyzed in correlation with immunoreactivity to the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), in the main retroperitoneal paraganglion, adrenal medullae and abdominal sympathetic ganglia. Catecholamines 78-91 tyrosine hydroxylase Rattus norvegicus 113-133 2746512-13 1989 The catecholamine responses to m-CPP appear to be partially mediated by 5-HT1C receptors and also by nonserotonergic mechanisms. Catecholamines 4-17 5-hydroxytryptamine receptor 2C Rattus norvegicus 72-78 2486602-4 1989 It was found that astroglial NGF synthesis was enhanced by the addition of catecholamine into the cultured medium or the co-culture with differentiated PC12 cells. Catecholamines 75-88 nerve growth factor Rattus norvegicus 29-32 2779729-5 1989 Additionally, 500 microM of metabolites of catecholamines that were both deaminated and 3-O-methylated exhibited high activity (greater than 3.0 pmol/mg/min specific activity) as substrates compared to p-nitrophenol as substrate for the PST. Catecholamines 43-57 sulfotransferase 1A1 Bos taurus 237-240 2779729-7 1989 Therefore, results from this study suggest a potential role for PST as part of the "enzymatic" blood-brain barrier in regulating transendothelial passage of endogeneous catecholamines between the blood and the brain. Catecholamines 169-183 sulfotransferase 1A1 Bos taurus 64-67 2567962-1 1989 In the olfactory bulb, tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is expressed after birth when the axons of olfactory epithelial neurons have made synapses in the bulb. Catecholamines 98-112 tyrosine hydroxylase Mus musculus 23-43 2567962-1 1989 In the olfactory bulb, tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is expressed after birth when the axons of olfactory epithelial neurons have made synapses in the bulb. Catecholamines 98-112 tyrosine hydroxylase Mus musculus 45-47 2567576-6 1989 Isolated lack of a growth hormone response caused a decrease in hepatic glucose production and an increase in glucose utilization that resulted in an approximately 25% greater hypoglycemia despite compensatory increases in plasma catecholamines. Catecholamines 230-244 growth hormone 1 Homo sapiens 19-33 2776081-6 1989 Measurement of catecholamine concentration of the supernatant from homogenates used for the Ang II binding assay revealed a significant correlation between the specific binding of Ang II to brain membranes of the two tryptophan-treated groups and the concentration of norepinephrine in the supernatant. Catecholamines 15-28 angiotensinogen Rattus norvegicus 92-98 2776081-6 1989 Measurement of catecholamine concentration of the supernatant from homogenates used for the Ang II binding assay revealed a significant correlation between the specific binding of Ang II to brain membranes of the two tryptophan-treated groups and the concentration of norepinephrine in the supernatant. Catecholamines 15-28 angiotensinogen Rattus norvegicus 180-186 2779729-2 1989 Selected catecholamines, catecholamine metabolites, and p-nitrophenol at 5, 50, and 500 microM were used as substrates in PST assays of cytosol extracts. Catecholamines 9-23 sulfotransferase 1A1 Bos taurus 122-125 2779729-2 1989 Selected catecholamines, catecholamine metabolites, and p-nitrophenol at 5, 50, and 500 microM were used as substrates in PST assays of cytosol extracts. Catecholamines 9-22 sulfotransferase 1A1 Bos taurus 122-125 2779729-3 1989 Endogenous catecholamines, epinephrine, norepinephrine, and dopamine, exhibited no detectable activity as substrates (500 microM) compared to 500 microM p-nitrophenol as substrate (1.8 pmol/mg/min specific activity) for the PST. Catecholamines 11-25 sulfotransferase 1A1 Bos taurus 224-227 2779729-4 1989 In contrast, 500 microM of either deaminated or 3-O-methylated metabolites of catecholamines exhibited intermediate (approximately 1.0 pmol/mg/min specific activity) to low (approximately 0.2 pmol/mg/min specific activity) activity, respectively, as substrates compared to p-nitrophenol as substrate for the PST. Catecholamines 78-92 sulfotransferase 1A1 Bos taurus 308-311 2470585-6 1989 These findings strengthen the assumption that VIP controls glucose and fatty acid metabolism by a cAMP-dependent mechanism and demonstrate, for the first time, that the contribution of substrates as energy fuel is under dual neurohormonal regulation by VIP and catecholamines in isolated rat enterocytes. Catecholamines 261-275 vasoactive intestinal peptide Rattus norvegicus 46-49 2486602-5 1989 These results suggest that NGF synthesis in the in vivo tissues is increased by the release of catecholamine as neurotransmitters and/or the contact of NGF-producing cells with differentiated cell bodies and neurites of NGF-sensitive neurons. Catecholamines 95-108 nerve growth factor Rattus norvegicus 27-30 2723636-4 1989 The NPY synthetic rate in cultures grown in complete serum free medium increased 30-fold after plating, in parallel to catecholamine synthesis; both NPY and the catecholamines reached the rate for adult SCG neurons. Catecholamines 119-132 neuropeptide Y Rattus norvegicus 4-7 2674445-9 1989 Finally, in CHF a variety of proarrhythmic factors, such as left ventricular dysfunction, raised catecholamine levels and, in particular, decreased potassium concentrations, are influenced beneficially by ACE inhibitors. Catecholamines 97-110 angiotensin-converting enzyme Sus scrofa 205-208 2541147-10 1989 The recent demonstration that catecholamines and locus ceruleus neurons influence the loss of CA1 neurons in the hippocampus suggests that it may play an important modulatory role. Catecholamines 30-44 carbonic anhydrase 1 Homo sapiens 94-97 2501000-0 1989 Release of luteinizing hormone-releasing hormone: interrelations between eicosanoids and catecholamines. Catecholamines 89-103 gonadotropin releasing hormone 1 Rattus norvegicus 11-48 2501000-8 1989 We conclude that LTC4 does not interact with the noradrenergic pathway and that the stimulatory effect of both catecholamines on LHRH release involves PGE2, but the inhibitory effect of DA is associated with reduced LTC4 production. Catecholamines 111-125 gonadotropin releasing hormone 1 Rattus norvegicus 129-133 2568905-1 1989 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenolic and catechol drugs. Catecholamines 67-81 sulfotransferase family 1A member 1 Homo sapiens 0-23 2541947-1 1989 The beta 1- and beta 2-adrenergic receptor subtypes are biochemically and functionally similar, because both receptors mediate the catecholamine-dependent activation of adenylate cyclase through the GTP-binding protein, Gs. Catecholamines 131-144 adrenoceptor beta 1 Homo sapiens 4-42 2543391-0 1989 Evidence for a peroxidatic oxidation of norepinephrine, a catecholamine, by lactoperoxidase. Catecholamines 58-71 lactoperoxidase Homo sapiens 76-91 2543391-1 1989 The electron spin resonance-spin stabilization technique has been applied to identify the o-semiquinone intermediate produced during the lactoperoxidase-catalyzed oxidation of the catecholamine norepinephrine. Catecholamines 180-193 lactoperoxidase Homo sapiens 137-152 2568905-1 1989 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenolic and catechol drugs. Catecholamines 67-81 sulfotransferase family 1A member 1 Homo sapiens 25-28 2524722-6 1989 The block of nicotinic ACh receptor channels may enable ANF to control the secretion of catecholamines from adrenal chromaffin cells. Catecholamines 88-102 natriuretic peptide A Bos taurus 56-59 2601863-7 1989 Together with the increment of catecholamines, high concentration of prolactin can evoke arrhythmias. Catecholamines 31-45 prolactin Homo sapiens 69-78 2714445-0 1989 Catecholamines increase nerve growth factor mRNA content in both mouse astroglial cells and fibroblast cells. Catecholamines 0-14 nerve growth factor Mus musculus 24-43 2571139-0 1989 Neuropeptide tyrosine (NPY)-induced potentiation of the pressor activity of catecholamines in conscious rats. Catecholamines 76-90 neuropeptide Y Rattus norvegicus 23-26 2714445-1 1989 Previous studies have shown that catecholamines increase the nerve growth factor (NGF) content in medium conditioned by mouse L-M fibroblast cells and mouse astroglial cells. Catecholamines 33-47 nerve growth factor Mus musculus 61-80 2714445-1 1989 Previous studies have shown that catecholamines increase the nerve growth factor (NGF) content in medium conditioned by mouse L-M fibroblast cells and mouse astroglial cells. Catecholamines 33-47 nerve growth factor Mus musculus 82-85 2714445-6 1989 These results indicate that catecholamines enhance NGF synthesis of L-M fibroblast cells and astroglial cells by increasing the cellular content of NGF mRNA. Catecholamines 28-42 nerve growth factor Mus musculus 51-54 2714445-6 1989 These results indicate that catecholamines enhance NGF synthesis of L-M fibroblast cells and astroglial cells by increasing the cellular content of NGF mRNA. Catecholamines 28-42 nerve growth factor Mus musculus 148-151 2713190-0 1989 Isoprenaline as an aid to the induction of catecholamine dependent supraventricular tachycardias during programmed stimulation. Catecholamines 43-56 activation induced cytidine deaminase Homo sapiens 19-22 2524228-4 1989 The data obtained show that the action of the atriopeptin is mediated by Na+-K+ pump activation of smooth muscle cells and restricts vasoconstriction of catecholamine effect. Catecholamines 153-166 natriuretic peptide A Homo sapiens 46-57 2538314-2 1989 hCG-induced desensitization was homologous (loss of responsiveness to LH) early (first 6 h), then became heterologous (partial loss of responsiveness to catecholamines) later (12-48 h). Catecholamines 153-167 glycoprotein hormones, alpha polypeptide Homo sapiens 0-3 2522835-8 1989 In atria from reserpinized rats, evidence for involvement of catecholamines in chronotropic-stimulated ANF release was suggested. Catecholamines 61-75 natriuretic peptide A Rattus norvegicus 103-106 2548638-1 1989 Bradykinin, angiotensin II and a muscarinic agonist, acetyl-B-methacholine (methacholine) were all found to elicit catecholamine release from cultured bovine adrenal chromaffin cells. Catecholamines 115-128 kininogen 1 Bos taurus 0-10 2647559-0 1989 Abnormal action of catecholamines on lipolysis in adipocytes of type I diabetic patients treated with insulin. Catecholamines 19-33 insulin Homo sapiens 102-109 2566714-2 1989 The two catecholamine enzyme immunoreactivities (phenylethanolamine-N-methyltransferase, and tyrosine-hydroxylase) were not found in the same cells, while gamma-aminobutyric acid (GABA) immunoreactivity was observed in large tyrosine-hydroxylase immunoreactive cells, but not in phenylethanolamine-N-methyltransferase immunoreactive cells. Catecholamines 8-21 phenylethanolamine-N-methyltransferase Rattus norvegicus 49-87 2647559-1 1989 Catecholamine-induced lipolysis was investigated in adipocytes obtained before and after 30 min of exercise from 10 insulin-treated type I (insulin-dependent) diabetic men and 10 male matched control subjects. Catecholamines 0-13 insulin Homo sapiens 116-123 2647559-1 1989 Catecholamine-induced lipolysis was investigated in adipocytes obtained before and after 30 min of exercise from 10 insulin-treated type I (insulin-dependent) diabetic men and 10 male matched control subjects. Catecholamines 0-13 insulin Homo sapiens 140-147 2547922-1 1989 1) The primary receptor mechanism of catecholamine-induced myocardial potassium uptake is beta 1-adrenoceptor stimulation. Catecholamines 37-50 adrenoceptor beta 1 Homo sapiens 90-109 2566714-2 1989 The two catecholamine enzyme immunoreactivities (phenylethanolamine-N-methyltransferase, and tyrosine-hydroxylase) were not found in the same cells, while gamma-aminobutyric acid (GABA) immunoreactivity was observed in large tyrosine-hydroxylase immunoreactive cells, but not in phenylethanolamine-N-methyltransferase immunoreactive cells. Catecholamines 8-21 phenylethanolamine-N-methyltransferase Rattus norvegicus 279-317 2704029-3 1989 The new compounds were also highly selective COMT inhibitors with no activity against other essential enzymes involved in the synthesis and metabolism of catecholamines. Catecholamines 154-168 catechol-O-methyltransferase Homo sapiens 45-49 2564853-1 1989 The light and electron microscopic localization of antigenic sites for a polyclonal antiserum directed against the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), was examined in the hippocampal formation of the rat brain with a double-bridged peroxidase-antiperoxidase method. Catecholamines 115-128 tyrosine hydroxylase Rattus norvegicus 150-170 2568326-1 1989 Neuropeptide Y (NPY) is widely distributed in the central and sympathetic nervous systems and has a variety of central actions including regulation of blood pressure and peripheral actions; e.g., continuous vasoconstriction and inhibition of catecholamine release. Catecholamines 242-255 neuropeptide Y Homo sapiens 0-14 2568326-1 1989 Neuropeptide Y (NPY) is widely distributed in the central and sympathetic nervous systems and has a variety of central actions including regulation of blood pressure and peripheral actions; e.g., continuous vasoconstriction and inhibition of catecholamine release. Catecholamines 242-255 neuropeptide Y Homo sapiens 16-19 2564853-1 1989 The light and electron microscopic localization of antigenic sites for a polyclonal antiserum directed against the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), was examined in the hippocampal formation of the rat brain with a double-bridged peroxidase-antiperoxidase method. Catecholamines 115-128 tyrosine hydroxylase Rattus norvegicus 172-174 2523760-13 1989 ANF in the peripheral neuronal system inhibits catecholamine synthesis and release. Catecholamines 47-60 natriuretic peptide A Rattus norvegicus 0-3 2537612-9 1989 Long-acting ACE inhibitors prolong the decreased efferent arteriolar tone and may compromise cardiac muscle response to catecholamines. Catecholamines 120-134 angiotensin I converting enzyme Homo sapiens 12-15 2468416-0 1989 Galanin-, neuropeptide Y- and enkephalin-like immunoreactivities in catecholamine-storing paraganglia of the fetal guinea pig and newborn pig. Catecholamines 68-81 galanin peptides Cavia porcellus 0-7 2646946-9 1989 This effect is due to the exquisite sensitivity of lipolysis to insulin and is overcome by catecholamine release during hypoglycemia. Catecholamines 91-104 insulin Homo sapiens 64-71 2648843-0 1989 Effects of insulin infusion on plasma catecholamine concentration in fetal sheep. Catecholamines 38-51 LOC105613195 Ovis aries 11-18 2765685-9 1989 We propose that C5a acts at a specific C5a/C5ai receptor to modulate catecholamine activity at the brain site. Catecholamines 69-82 complement C5 Rattus norvegicus 16-19 2765685-9 1989 We propose that C5a acts at a specific C5a/C5ai receptor to modulate catecholamine activity at the brain site. Catecholamines 69-82 complement C5 Rattus norvegicus 39-42 2468416-0 1989 Galanin-, neuropeptide Y- and enkephalin-like immunoreactivities in catecholamine-storing paraganglia of the fetal guinea pig and newborn pig. Catecholamines 68-81 pro-neuropeptide Y Cavia porcellus 10-24 2566632-2 1989 The coexistence of GAD with the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) was analyzed in consecutive sections or by staining one section consecutively with different antisera. Catecholamines 32-45 phenylethanolamine-N-methyltransferase Rattus norvegicus 137-141 2930478-2 1989 High levels of cystatin S mRNA persist in glands of chronically treated animals for 6 days after discontinuation of the catecholamine, indicating a long half-life of the mRNA. Catecholamines 120-133 cystatin S Rattus norvegicus 15-25 2469096-4 1989 The low DBH group may be more genetically homogeneous with regard to catecholamine function, making relationships between catecholamine function and behavior more visible. Catecholamines 69-82 dopamine beta-hydroxylase Homo sapiens 8-11 2469096-4 1989 The low DBH group may be more genetically homogeneous with regard to catecholamine function, making relationships between catecholamine function and behavior more visible. Catecholamines 122-135 dopamine beta-hydroxylase Homo sapiens 8-11 2563753-3 1989 The correlative subcellular determination of the TH amount and activity in the same tissue could be a useful approach for studying experimentally induced mechanisms of catecholamine synthesis modulation in different brain catecholaminergic pathways. Catecholamines 168-181 tyrosine hydroxylase Rattus norvegicus 49-51 2923000-1 1989 Catecholamine content in the recurrent and superior laryngeal nerves (RLN and SLN) of the rat was analysed by high-performance liquid chromatography after surgical and chemical sympathectomy. Catecholamines 0-13 sarcolipin Rattus norvegicus 78-81 2495846-3 1989 Catecholamine depletion in 6-OHDA-treated rats resulted in a 55% decrease in the pressor response to ICV Ang II which was not associated with any significant change in the binding of 125I-sarcosine1, isoleucine8 Ang II to Ang II binding sites in the HTSM or brainstem. Catecholamines 0-13 angiogenin Rattus norvegicus 105-108 2913369-10 1989 In the intrinsic external urethral sphincter, located in the distal urethra, vasoactive intestinal polypeptide- and gastrin-immunoreactive nerve fibres were found bordering a small number of individual striated muscle fibres, while catecholamine-containing nerves were found predominantly in the connective tissue surrounding the striated muscle fibres. Catecholamines 232-245 gastrin Sus scrofa 116-123 2563778-9 1989 Blood glucose and insulin levels were significantly elevated in the resuscitated shocked dogs, likely due to increased circulating catecholamine concentrations and enhanced glycogenolysis. Catecholamines 131-144 insulin Canis lupus familiaris 18-25 2537324-7 1989 On the other hand, met-enkephalin induced a dose-dependent increase in macrophage spreading, with a perimeter of 18.5 +/- 1.0 microns at 10(-8) M. Since catecholamines and opioids are simultaneously released from chromaffin cells of the adrenal, we examined the combinative effects due to treatment with both ligands. Catecholamines 153-167 proopiomelanocortin Homo sapiens 19-33 2566138-1 1989 We carried out an immunohistochemical study of the Auerbach"s and Meissner"s plexuses of the human alimentary tract, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme of the catecholamine-synthesizing pathway. Catecholamines 198-211 tyrosine hydroxylase Homo sapiens 141-161 2927024-8 1989 These findings suggest that NT in plasma may function as a circulating hormone to exhibit an inhibitory action on the excitatory neural input to the rectum in the chicken, and that catecholamine release from adrenergic nerve terminals by NT may account for some but not all of the activity. Catecholamines 181-194 neurotensin Gallus gallus 238-240 2715273-4 1989 These HPLC assays are sufficiently sensitive and rapid to replace the use of [3H]amines and column chromatographic separation of the metabolites for most in vitro studies on the uptake and subsequent metabolism of catecholamines by monoamine oxidase and/or catechol-O-methyltransferase in tissues. Catecholamines 214-228 catechol-O-methyltransferase Homo sapiens 257-285 2567605-1 1989 A parietal lobe ganglioglioma in a 61-year-old male was investigated ultrastructurally and immunohistochemically, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme of the catecholamine (CA)-synthesizing pathway. Catecholamines 195-208 tyrosine hydroxylase Homo sapiens 138-158 2567605-1 1989 A parietal lobe ganglioglioma in a 61-year-old male was investigated ultrastructurally and immunohistochemically, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme of the catecholamine (CA)-synthesizing pathway. Catecholamines 195-208 tyrosine hydroxylase Homo sapiens 160-162 2566138-1 1989 We carried out an immunohistochemical study of the Auerbach"s and Meissner"s plexuses of the human alimentary tract, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme of the catecholamine-synthesizing pathway. Catecholamines 198-211 tyrosine hydroxylase Homo sapiens 163-165 2573340-1 1989 Dopexamine is a newly developed sympathetic catecholamine which combines dopaminergic (DA-1) and beta 2-adrenergic agonist activity with only minor beta 1-adrenergic action. Catecholamines 44-57 immunoglobulin heavy diversity 4-11 (non-functional) Homo sapiens 87-91 2644003-13 1989 These data suggest that LHRH neurons in estrogen-primed OVX rats are not particularly responsive to NE and that following MPN-ECS, LHRH neuronal responsiveness to this catecholamine markedly increases. Catecholamines 168-181 gonadotropin releasing hormone 1 Rattus norvegicus 131-135 2730337-0 1989 Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication: increases in brain catecholamine and 5-hydroxytryptamine levels. Catecholamines 94-107 monoamine oxidase A Rattus norvegicus 0-17 2563268-0 1989 Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase. Catecholamines 0-13 tyrosine hydroxylase Homo sapiens 106-126 2563268-0 1989 Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-beta-hydroxylase. Catecholamines 0-13 dopamine beta-hydroxylase Homo sapiens 131-156 2718795-7 1989 We believe that the most appropriate explanation for this hypokalaemia is the large catecholamine discharge that is known to accompany severe head trauma, with resultant beta 2-adrenergic stimulation of the Na+ -K+ pump. Catecholamines 84-97 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 170-176 2510787-4 1989 Our studies suggest that glial protein S100 may be involved in the regulation of cell growth and differentiation, while neuronal protein 14-3-3, in the regulation of serotonin and catecholamine biosynthesis in neurons and other monoamine-synthesizing cells. Catecholamines 180-193 S100 calcium binding protein B Homo sapiens 39-43 2634963-0 1989 Inhibition of human lecithin: cholesterol acyltransferase activity by catecholamines in vitro. Catecholamines 70-84 lecithin-cholesterol acyltransferase Homo sapiens 20-57 2518613-6 1989 To confirm the validity of these results, specific antibodies to tyrosine hydroxylase (TH) and aromatic 1-aminoacid-decarboxylase (AADC), two enzymes involved in the synthesis of catecholamines, were used. Catecholamines 179-193 dopa decarboxylase Rattus norvegicus 131-135 2619736-4 1989 Distinctly higher plasma activities of CK, isoenzymes of LDH and ASAT as well as markedly lower CK activities in the myocardium point to an enhanced sensitivity of SHR to catecholamine-induced damage. Catecholamines 171-184 glutamic-oxaloacetic transaminase 1 Rattus norvegicus 65-69 2634963-4 1989 Since diminished LCAT activity is known to be followed by a low level of HDL cholesterol and an increased concentration of triglycerides, it is supposed that catecholamine mediated inhibition of LCAT activity may contribute to the development of stress mediated fluctuations in plasma lipoprotein concentrations. Catecholamines 158-171 lecithin-cholesterol acyltransferase Homo sapiens 17-21 2634963-4 1989 Since diminished LCAT activity is known to be followed by a low level of HDL cholesterol and an increased concentration of triglycerides, it is supposed that catecholamine mediated inhibition of LCAT activity may contribute to the development of stress mediated fluctuations in plasma lipoprotein concentrations. Catecholamines 158-171 lecithin-cholesterol acyltransferase Homo sapiens 195-199 2600284-0 1989 Use of catecholamines in CPR. Catecholamines 7-21 cytochrome p450 oxidoreductase Homo sapiens 25-28 2537703-4 1989 To investigate the mechanisms of these changes in renal function, nocturnal urinary excretion of catecholamines and guanosine 3":5"-cyclic monophosphate (cyclic GMP), which reflects atrial natriuretic factor (ANF) release, and next-morning plasma active renin concentrations were studied in 21 OSA patients on 2 consecutive nights, either untreated or treated with nasal CPAP. Catecholamines 97-111 natriuretic peptide A Homo sapiens 182-207 2470440-5 1989 It is suggested that NK-1 mediate peripheral vasodilatation and exocrine secretions, NK-2 stimulate bronchial muscles and facilitate the release of catecholamines, and NK-3 promote the release of acetylcholine in peripheral organs. Catecholamines 148-162 tachykinin precursor 1 Homo sapiens 85-89 2483424-6 1989 The synthesis of renin is initiated when the cAMP concentration increases under the influence of hormones (parathyroid hormone, catecholamines), of mediators (e.g., prostanoids), or of changes in composition of tubular fluid (in sodium, chlorine, or calcium) detected by the macula densa. Catecholamines 128-142 renin Homo sapiens 17-22 2562802-1 1989 In situ hybridization was used to examine the appearance of mRNA specific for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine (CA) biosynthesis, in neural crest derivatives of the rat embryo. Catecholamines 133-146 tyrosine hydroxylase Rattus norvegicus 78-98 2473320-0 1989 Characterization of endothelin-1 stimulation of catecholamine release from adrenal chromaffin cells. Catecholamines 48-61 endothelin 1 Bos taurus 20-32 2473355-3 1989 In these studies and other high dose constant infusion experiments, the response of the renin-angiotension-aldosterone system and plasma catecholamines was varied, either remaining unchanged or showing stimulation when high doses of ANF caused acute and substantial falls in blood pressure. Catecholamines 137-151 renin Homo sapiens 88-93 2473355-3 1989 In these studies and other high dose constant infusion experiments, the response of the renin-angiotension-aldosterone system and plasma catecholamines was varied, either remaining unchanged or showing stimulation when high doses of ANF caused acute and substantial falls in blood pressure. Catecholamines 137-151 natriuretic peptide A Homo sapiens 233-236 2473357-1 1989 The effects of synthetic human atrial natriuretic peptide (ANP) on the release of catecholamines, aldosterone, or cortisol were observed in human adrenal tumors obtained surgically from patients with pheochromocytoma, primary aldosteronism, or Cushing"s syndrome, respectively. Catecholamines 82-96 natriuretic peptide A Homo sapiens 31-57 2473357-1 1989 The effects of synthetic human atrial natriuretic peptide (ANP) on the release of catecholamines, aldosterone, or cortisol were observed in human adrenal tumors obtained surgically from patients with pheochromocytoma, primary aldosteronism, or Cushing"s syndrome, respectively. Catecholamines 82-96 natriuretic peptide A Homo sapiens 59-62 2473357-5 1989 Release of catecholamines from pheochromocytoma tissues was inhibited by ANP, and the presence of the ANP receptor on pheochromocytoma was further demonstrated by both binding assays and affinity labeling; Scatchard analysis revealed a single class of binding sites for ANP with a Kd of 1.0 nM and a Bmax of 0.4 pmol/mg of protein and the molecular size was estimated as 140 and a 70 kDa under nonreducing and reducing conditions, respectively. Catecholamines 11-25 natriuretic peptide A Homo sapiens 73-76 2473357-5 1989 Release of catecholamines from pheochromocytoma tissues was inhibited by ANP, and the presence of the ANP receptor on pheochromocytoma was further demonstrated by both binding assays and affinity labeling; Scatchard analysis revealed a single class of binding sites for ANP with a Kd of 1.0 nM and a Bmax of 0.4 pmol/mg of protein and the molecular size was estimated as 140 and a 70 kDa under nonreducing and reducing conditions, respectively. Catecholamines 11-25 natriuretic peptide A Homo sapiens 102-105 2473357-5 1989 Release of catecholamines from pheochromocytoma tissues was inhibited by ANP, and the presence of the ANP receptor on pheochromocytoma was further demonstrated by both binding assays and affinity labeling; Scatchard analysis revealed a single class of binding sites for ANP with a Kd of 1.0 nM and a Bmax of 0.4 pmol/mg of protein and the molecular size was estimated as 140 and a 70 kDa under nonreducing and reducing conditions, respectively. Catecholamines 11-25 natriuretic peptide A Homo sapiens 102-105 2562802-1 1989 In situ hybridization was used to examine the appearance of mRNA specific for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine (CA) biosynthesis, in neural crest derivatives of the rat embryo. Catecholamines 133-146 tyrosine hydroxylase Rattus norvegicus 100-102 2796596-1 1989 The purpose of this study was to evaluate the effects of the millimicrons opioid agonist D-Ala-2-Me-Phe-4-Gly-ol enkephalin (DAGO) on catecholamine-induced arrhythmias. Catecholamines 134-147 proenkephalin Rattus norvegicus 113-123 2622531-1 1989 The binding of [3H]dihydrotetrabenazine, a specific ligand of the monoamine transporter present on serotonin and catecholamine synaptic vesicles, was studied on rat brain sections. Catecholamines 113-126 solute carrier family 18 member A2 Rattus norvegicus 66-87 2915604-0 1989 Neurotensin affects metabolism of opioid peptides, catecholamines and inositol phospholipids in bovine chromaffin cells. Catecholamines 51-65 neurotensin Bos taurus 0-11 2915604-1 1989 Bovine adrenal medullary cells released significant amounts of opioid pentapeptides Met- and Leu-enkephalin and catecholamines, when stimulated by neurotensin (NT). Catecholamines 112-126 neurotensin Bos taurus 147-158 2483108-2 1989 In this investigation we demonstrate in these cousins deletion of the MAOA gene, undetectable levels of MAO-A and MAO-B activities in their fibroblasts and platelets, respectively, loss of mRNA for MAO-A in fibroblasts, and substantial alterations in urinary catecholamine metabolites. Catecholamines 259-272 monoamine oxidase A Homo sapiens 70-74 2511501-2 1989 Stimulation within the A1 catecholamine cell group in the ventrolateral medulla also activates supraoptic neurons and releases vasopressin. Catecholamines 26-39 arginine vasopressin Rattus norvegicus 127-138 2497396-0 1989 Role of hypothalamic catecholamines in the regulation of luteinizing hormone and prolactin secretion in the ewe during seasonal anestrus. Catecholamines 21-35 prolactin Homo sapiens 81-90 2788829-4 1989 Reserpine, which is known to deplete catecholamines, also caused release of the interleukin-1-like immunoreactive material. Catecholamines 50-64 interleukin 1 alpha Homo sapiens 93-106 2566989-2 1989 Some salient aspects of the role of gamma-aminobutyric acid in the control of prolactin secretion and of catecholamines and acetylcholine in the control of growth hormone secretion are reviewed, also underlying some diagnostic and therapeutic applications of the new findings in neuroendocrine disorders. Catecholamines 105-119 growth hormone 1 Homo sapiens 156-170 2922105-4 1989 NPY, alone, had no effect on secretion from the adrenal gland but produced a dose dependent increase in the secretion of enkephalin-like peptides and catecholamines when the cholinergic agonist, 1,1 dimethyl-4-phenylpiperizinium iodide, was present. Catecholamines 150-164 neuropeptide Y Bos taurus 0-3 2922105-8 1989 In contrast to the potentiation observed in the perfused adrenal gland, NPY (1 X 10(-8) M) inhibited the cholinergic mediated release of enkephalin-like peptides and catecholamines from cultured bovine chromaffin cells. Catecholamines 166-180 neuropeptide Y Bos taurus 72-75 2664885-5 1989 NPY seems to coexist with other on neurotransmitters like somatostatin, galanin, GABA and the catecholamines noradrenaline and adrenaline in discrete brain regions. Catecholamines 94-108 neuropeptide Y Homo sapiens 0-3 2655147-0 1989 Gonadotropin releasing hormone (GnRH) neurons are directly innervated by catecholamine terminals. Catecholamines 73-86 gonadotropin releasing hormone 1 Homo sapiens 0-30 2749007-0 1989 Role of circulating catecholamines in the control of pancreatic polypeptide and gastrin release. Catecholamines 20-34 pancreatic polypeptide Homo sapiens 53-75 2749007-0 1989 Role of circulating catecholamines in the control of pancreatic polypeptide and gastrin release. Catecholamines 20-34 gastrin Homo sapiens 80-87 2749007-1 1989 The influence of circulating catecholamines on the release of pancreatic polypeptide (PP) and gastrin was studied in volunteers. Catecholamines 29-43 pancreatic polypeptide Homo sapiens 62-89 2749007-1 1989 The influence of circulating catecholamines on the release of pancreatic polypeptide (PP) and gastrin was studied in volunteers. Catecholamines 29-43 gastrin Homo sapiens 94-101 2655147-0 1989 Gonadotropin releasing hormone (GnRH) neurons are directly innervated by catecholamine terminals. Catecholamines 73-86 gonadotropin releasing hormone 1 Homo sapiens 32-36 3263967-2 1988 In order to study the regulation of growth and gene expression by catecholamines, we have isolated and sequenced several cDNA clones encoding the LM protein. Catecholamines 66-80 cystatin S Rattus norvegicus 146-156 2904432-2 1988 Tyrosine 3-monooxygenase (tyrosine hydroxylase) is a non-heme iron, tetrahydropterin-dependent enzyme which catalyzes the rate-limiting step in the biosynthesis of catecholamines. Catecholamines 164-178 tyrosine hydroxylase Bos taurus 0-24 2904432-2 1988 Tyrosine 3-monooxygenase (tyrosine hydroxylase) is a non-heme iron, tetrahydropterin-dependent enzyme which catalyzes the rate-limiting step in the biosynthesis of catecholamines. Catecholamines 164-178 tyrosine hydroxylase Bos taurus 26-46 2904432-10 1988 The high affinity of the catecholamines to the nonphosphorylated form of tyrosine hydroxylase may have significance in vivo since catecholamines are potent feedback inhibitors of the enzyme. Catecholamines 25-39 tyrosine hydroxylase Bos taurus 73-93 2904432-10 1988 The high affinity of the catecholamines to the nonphosphorylated form of tyrosine hydroxylase may have significance in vivo since catecholamines are potent feedback inhibitors of the enzyme. Catecholamines 130-144 tyrosine hydroxylase Bos taurus 73-93 2711742-5 1989 The cholinergic neurones are shown to participate in producing small-intestinal responses to 5-hydroxytryptamine, histamine, bradykinin, the responses being, for this reason, dependent on the level of catecholamines, stimulating excitatory beta-adrenoreceptors. Catecholamines 201-215 kininogen 1 Homo sapiens 125-135 2906418-3 1988 This study reveals, for the first time, the differences in the respective topography of those neurons which actually contain detectable DA and those which contain TH, the initial synthesizing enzyme of catecholamine. Catecholamines 202-215 tyrosine hydroxylase Rattus norvegicus 163-165 2977154-2 1988 Our data show that ornithine decarboxylase is independently regulated by ventricular wall stress and adrenergic receptors, and support the theory that catecholamines have a pressure-independent trophic effect. Catecholamines 151-165 ornithine decarboxylase 1 Rattus norvegicus 19-42 2849322-1 1988 The purpose of this study was to test the hypothesis that, in the presence of high circulating catecholamines, ACTH decreases renal excretory capability and that its natriuretic effects are caused by increased renal arterial pressure (RAP). Catecholamines 95-109 proopiomelanocortin Canis lupus familiaris 111-115 3202164-1 1988 Neuropeptide Y (NPY), a peptide often coreleased with catecholamines, appears to be an important component of the sympathetic nervous system, but little is known about the molecular basis of its action. Catecholamines 54-68 neuropeptide Y Homo sapiens 0-14 3202164-1 1988 Neuropeptide Y (NPY), a peptide often coreleased with catecholamines, appears to be an important component of the sympathetic nervous system, but little is known about the molecular basis of its action. Catecholamines 54-68 neuropeptide Y Homo sapiens 16-19 3224284-9 1988 Together with other evidence, these results suggest that adrenergic as well as noradrenergic innervation to the PVN has a key role in the behavioral and endocrine systems of this nucleus and, moreover, that NPY generally mimics the effects of these catecholamines in the PVN. Catecholamines 249-263 neuropeptide Y Rattus norvegicus 207-210 3253235-0 1988 Ski-flying: related catecholamine excretion compared with cross-country skiing. Catecholamines 20-33 SKI proto-oncogene Homo sapiens 0-3 3253235-1 1988 We examined the catecholamine excretion and its performance-diagnostic relevance in athletes of the German National Team during ski-flying and cross-country skiing. Catecholamines 16-29 SKI proto-oncogene Homo sapiens 128-131 2977154-5 1988 Further investigation showed that ornithine decarboxylase stimulation by catecholamines, unlike ornithine decarboxylase basal activity, was dependent on the extracellular calcium level. Catecholamines 73-87 ornithine decarboxylase 1 Rattus norvegicus 34-57 3193032-1 1988 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and of phenolic drugs. Catecholamines 67-81 sulfotransferase family 1A member 1 Homo sapiens 0-23 2973318-0 1988 Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs. Catecholamines 65-79 natriuretic peptide A Canis lupus familiaris 11-36 3193032-1 1988 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and of phenolic drugs. Catecholamines 67-81 sulfotransferase family 1A member 1 Homo sapiens 25-28 2905474-3 1988 This holds for the following neuro-endocrine mechanisms: 1) increased activity of the sympathetic nervous system and high plasma catecholamines, accompanied by down-regulation of beta 1- but not beta 2-receptors in the heart; 2) stimulation of the renin-angiotensin-aldosterone system (RAAS), causing higher levels of renin, A II and aldosterone. Catecholamines 129-143 renin Homo sapiens 248-253 2905474-5 1988 Drug treatment aiming to reduce or suppress these processes and their negative results is potentially offered by: vasodilators, counteracting vasoconstriction, low dose selective beta 1-adrenoceptor blockers, which will not only impair tachycardia but also up-regulate cardiac beta 1-receptors and hence improve the inotropic response to catecholamines; aldosterone antagonists and ACE-inhibitors counteracting the activated RAAS. Catecholamines 338-352 adrenoceptor beta 1 Homo sapiens 179-198 3181426-0 1988 Calcium-dependence of chromogranin A-catecholamine interaction. Catecholamines 37-50 chromogranin A Bos taurus 22-36 3181426-4 1988 It is shown that chromogranin A can bind (i) about 0.5 mol catecholamines per mol in a non-calcium-dependent manner and (ii) about 5 mol per mol in the presence of calcium. Catecholamines 59-73 chromogranin A Bos taurus 17-31 2903502-4 1988 After administration of the catecholamine-depleting drug reserpine to rats, a brief increase, followed by a dramatic decrease, in the level of PNMTase mRNA was observed in the adrenal medulla. Catecholamines 28-41 phenylethanolamine-N-methyltransferase Rattus norvegicus 143-150 2853087-1 1988 Insulin-induced hypoglycaemia causes profound haemodynamic changes, commonly ascribed to catecholamine increase. Catecholamines 89-102 insulin Homo sapiens 0-7 2853087-8 1988 The increase of plasma renin activity, in turn, is attributable both to the increased catecholamine concentrations and to the decreased potassium levels. Catecholamines 86-99 renin Homo sapiens 23-28 3237322-1 1988 The effects of acetylcholine, arginine vasopressin (AVP) and oxytocin (OXT) on both catecholamine and steroid secretion have been investigated using the isolated rat adrenal gland perfused in situ. Catecholamines 84-97 arginine vasopressin Rattus norvegicus 52-55 3237322-1 1988 The effects of acetylcholine, arginine vasopressin (AVP) and oxytocin (OXT) on both catecholamine and steroid secretion have been investigated using the isolated rat adrenal gland perfused in situ. Catecholamines 84-97 oxytocin/neurophysin I prepropeptide Rattus norvegicus 71-74 3237322-4 1988 AVP at 100 nmol/l but not at 1 nmol/l significantly stimulated the secretion of both steroids and catecholamines. Catecholamines 98-112 arginine vasopressin Rattus norvegicus 0-3 2459120-0 1988 Insulin antagonism of catecholamine stimulation of fatty acid transport in the adipocyte. Catecholamines 22-35 insulin Homo sapiens 0-7 3068709-4 1988 To investigate the possibility that catecholamines or serotonin might be involved in the effect of NPY in LH secretion, castrated rats were treated with alpha-methylparatyrosine (alpha-MPT), an inhibitor of catecholamine biosynthesis, or received an i.c.v. Catecholamines 36-50 neuropeptide Y Rattus norvegicus 99-102 3068709-4 1988 To investigate the possibility that catecholamines or serotonin might be involved in the effect of NPY in LH secretion, castrated rats were treated with alpha-methylparatyrosine (alpha-MPT), an inhibitor of catecholamine biosynthesis, or received an i.c.v. Catecholamines 36-49 neuropeptide Y Rattus norvegicus 99-102 2844816-1 1988 The mechanisms by which insulin inhibits catecholamine-induced lipolysis in fat cells are unknown. Catecholamines 41-54 insulin Homo sapiens 24-31 2459120-2 1988 Insulin at physiological concentrations can suppress catecholamine activation of the membrane transport of long chain fatty acids in the adipocyte. Catecholamines 53-66 insulin Homo sapiens 0-7 2901339-3 1988 Catecholamines measured in aliquots of perfusate samples revealed that in vivo NE release was also pulsatile and was synchronous with LHRH release. Catecholamines 0-14 gonadotropin releasing hormone 1 Macaca mulatta 134-138 3185991-0 1988 Stimulatory effect of vasoactive intestinal polypeptide on catecholamine secretion from isolated guinea pig adrenal chromaffin cells. Catecholamines 59-72 VIP peptides Cavia porcellus 22-55 3185991-1 1988 The stimulatory effect of vasoactive intestinal polypeptide (VIP) on catecholamine (CA) secretion from isolated guinea pig adrenal chromaffin cell was studied. Catecholamines 69-82 VIP peptides Cavia porcellus 26-59 3185991-1 1988 The stimulatory effect of vasoactive intestinal polypeptide (VIP) on catecholamine (CA) secretion from isolated guinea pig adrenal chromaffin cell was studied. Catecholamines 69-82 VIP peptides Cavia porcellus 61-64 2843407-0 1988 Opposite effects of insulin and catecholamines on LDL-receptor activity in human mononuclear leukocytes. Catecholamines 32-46 low density lipoprotein receptor Homo sapiens 50-62 2843407-1 1988 The mechanisms by which insulin and catecholamines affect low-density lipoprotein (LDL)-receptor activity were studied in freshly isolated human mononuclear leukocytes. Catecholamines 36-50 low density lipoprotein receptor Homo sapiens 58-96 2843407-10 1988 The catecholamine action appears to be mediated by beta 2-adrenergic receptors. Catecholamines 4-17 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 51-57 3139484-3 1988 Receptors such as those for beta- and alpha-adrenergic catecholamines, muscarinic agonists, and the retinal photoreceptor rhodopsin, catalyze the exchange of GDP for GTP binding to the alpha subunit of a specific G protein. Catecholamines 55-69 rhodopsin Homo sapiens 122-131 2843407-11 1988 A suppression of LDL-receptor activity resulting from deficiency of insulin and elevated plasma catecholamine concentrations in uncontrolled insulin-dependent diabetic patients may contribute to the increased levels of LDL cholesterol observed in these patients. Catecholamines 96-109 low density lipoprotein receptor Homo sapiens 17-29 2846338-2 1988 Immunohistochemical labeling of medullary neurons containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine N-methyltransferase was used to reveal the anatomical location of A1 noradrenergic neurons within the ventrolateral medulla. Catecholamines 65-78 dopamine beta-hydroxylase Rattus norvegicus 122-147 2906609-8 1988 These results suggest that renal alpha 2-adrenoceptors may mediate the inhibition of the renal action of vasopressin by adrenal catecholamines. Catecholamines 128-142 arginine vasopressin Rattus norvegicus 105-116 2903868-1 1988 Two types of amacrine cell immunoreactive for tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine (CA)-synthetic pathway, are described in the rhesus monkey retina with the indirect-immunofluorescent method. Catecholamines 105-118 tyrosine hydroxylase Macaca mulatta 46-66 2903868-1 1988 Two types of amacrine cell immunoreactive for tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine (CA)-synthetic pathway, are described in the rhesus monkey retina with the indirect-immunofluorescent method. Catecholamines 105-118 tyrosine hydroxylase Macaca mulatta 68-70 2464453-0 1988 [A study on catecholamine metabolites in CSF in a patient with progressive dystonia with marked diurnal fluctuation]. Catecholamines 12-25 colony stimulating factor 2 Homo sapiens 41-44 3420405-1 1988 Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin. Catecholamines 185-199 lipase E, hormone sensitive type Homo sapiens 0-24 2851354-13 1988 (-)-Atenolol inhibited the catecholamine-induced adenylate cyclase stimulation in the atrium and ventricle with pKB values of 5.8-6.4 for beta 1- and pKB values of 4.7-5.7 for beta 2-adrenoceptors. Catecholamines 27-40 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 138-144 2902899-11 1988 Catecholamines are known to co-exist with NPY in certain rostrally projecting brainstem nuclei. Catecholamines 0-14 neuropeptide Y Rattus norvegicus 42-45 2460186-1 1988 The neuropeptide substance P (SP) has been reassessed for its ability to modify nicotine-induced catecholamine secretion from cultured bovine, adrenal chromaffin cells. Catecholamines 97-110 tachykinin precursor 1 Bos taurus 17-28 2460186-1 1988 The neuropeptide substance P (SP) has been reassessed for its ability to modify nicotine-induced catecholamine secretion from cultured bovine, adrenal chromaffin cells. Catecholamines 97-110 tachykinin precursor 1 Bos taurus 30-32 2851354-13 1988 (-)-Atenolol inhibited the catecholamine-induced adenylate cyclase stimulation in the atrium and ventricle with pKB values of 5.8-6.4 for beta 1- and pKB values of 4.7-5.7 for beta 2-adrenoceptors. Catecholamines 27-40 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 176-182 3071444-6 1988 These results indicate a significant difference in the effect of insulin treatment on the altered diabetic vascular responsiveness to catecholamines and adenosine or to prostacyclin. Catecholamines 134-148 insulin Canis lupus familiaris 65-72 2460342-1 1988 Cytochrome b561 is a transmembrane electron transport protein that is specific to a subset of secretory vesicles containing catecholamines and amidated peptides. Catecholamines 124-138 cytochrome b561 Bos taurus 0-15 3243966-0 1988 Possible direct effect of prolactin on catecholamine synthesis and release in rat adrenal medulla: in vitro studies. Catecholamines 39-52 prolactin Rattus norvegicus 26-35 2850308-6 1988 It appears that the acute cardiovascular response to gamma-MSH administration depends primarily on the release of sympathetic terminal norepinephrine, though some contribution from other pressor systems such as adrenal catecholamines is possible. Catecholamines 219-233 proopiomelanocortin Homo sapiens 53-62 2901433-0 1988 Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro. Catecholamines 0-13 corticotropin releasing hormone Rattus norvegicus 44-75 3243966-1 1988 It has been recently shown that chronic increase in circulating prolactin (PRL) levels can affect the catecholamine (CA) synthesis and release in the adrenal medulla of female and male rats. Catecholamines 102-115 prolactin Rattus norvegicus 64-73 3243966-1 1988 It has been recently shown that chronic increase in circulating prolactin (PRL) levels can affect the catecholamine (CA) synthesis and release in the adrenal medulla of female and male rats. Catecholamines 102-115 prolactin Rattus norvegicus 75-78 2483102-4 1988 When these cell populations were cultured, the HNK-1+ sorted cells differentiated into melanocytes, unpigmented cells, and numerous catecholamine-positive (CA+) cells. Catecholamines 132-145 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus 47-52 3231703-7 1988 It is concluded that the contractures induced by Na+ depletion result from the stimulation of postjunctional alpha-adrenoceptors by endogenously released catecholamines from the adrenergic nerve terminals innervating the vas deferens smooth muscle. Catecholamines 154-168 arginine vasopressin Rattus norvegicus 221-224 3263584-4 1988 This effect was completely abolished by prior administration of the catecholamine uptake inhibitor, nomifensine (13-69 mg/kg s.c.), which prevents the toxic metabolite of MPTP 1-methyl-4-phenylpyridine (MPP+) from entering dopaminergic neurones. Catecholamines 68-81 MPTP sensitivity 1 Mus musculus 171-177 3181288-1 1988 Catechol-O-methyltransferase (COMT) has an important role in the extraneuronal inactivation of catecholamine neurotransmitters and drugs with a catechol structure. Catecholamines 95-108 catechol-O-methyltransferase Rattus norvegicus 0-28 3181288-1 1988 Catechol-O-methyltransferase (COMT) has an important role in the extraneuronal inactivation of catecholamine neurotransmitters and drugs with a catechol structure. Catecholamines 95-108 catechol-O-methyltransferase Rattus norvegicus 30-34 3171466-1 1988 An immunocytochemical staining technique was used to investigate the development of the sheep adrenal medullary cells containing enkephalins and the catecholamine synthetic enzymes dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 149-162 dopamine beta-hydroxylase (dopamine beta-monooxygenase) Ovis aries 181-206 2846457-2 1988 For this purpose these conjugated catecholamines (CA) were synthesized and investigated with respect to their alpha 2- and beta 2-adrenoceptor affinities and their biological activity in three different human cell systems: in mononuclear leukocytes (MNL), platelets, and fat cells. Catecholamines 34-48 adrenoceptor beta 2 Homo sapiens 110-142 2459544-7 1988 These results are compatible with circulating NPY arising from the sympathetic nervous system, with release being controlled by the mechanisms already established for catecholamines. Catecholamines 167-181 neuropeptide Y Rattus norvegicus 46-49 3171466-1 1988 An immunocytochemical staining technique was used to investigate the development of the sheep adrenal medullary cells containing enkephalins and the catecholamine synthetic enzymes dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 149-162 dopamine beta-hydroxylase (dopamine beta-monooxygenase) Ovis aries 208-211 2839623-1 1988 Histamine, bradykinin, and angiotensin II stimulate release of catecholamines from adrenal medulla. Catecholamines 63-77 kininogen 1 Bos taurus 11-21 3138577-0 1988 Differential effects of hypothalamic catecholamine depletion on the release of arginine vasopressin and CRF-41 into hypothalamo-hypophyseal portal blood. Catecholamines 37-50 arginine vasopressin Homo sapiens 88-99 3407677-1 1988 Neuropeptide Y (NPY) is a 36-amino-acid polypeptide which coexists with catecholamines in many adrenergic and noradrenergic neurons. Catecholamines 72-86 neuropeptide Y Homo sapiens 0-14 2901439-3 1988 As a first step in analyzing the functional biochemical anatomy of catecholamine neurons in the human, we used antisera against tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) to localize medullary catecholamine-containing neurons and processes in the VLM and the NTS. Catecholamines 226-239 phenylethanolamine N-methyltransferase Homo sapiens 198-202 3407677-1 1988 Neuropeptide Y (NPY) is a 36-amino-acid polypeptide which coexists with catecholamines in many adrenergic and noradrenergic neurons. Catecholamines 72-86 neuropeptide Y Homo sapiens 16-19 2967888-5 1988 Cells cultured with IGF-I (10 nM) for 4 days exhibited an almost twofold increase in high K+-evoked catecholamine secretion. Catecholamines 100-113 insulin like growth factor 1 Bos taurus 20-25 2838252-2 1988 ANP-like immunoreactivity (ANP-LI) has also been identified in catecholamine-secreting cells. Catecholamines 63-76 natriuretic peptide A Rattus norvegicus 0-3 2838252-2 1988 ANP-like immunoreactivity (ANP-LI) has also been identified in catecholamine-secreting cells. Catecholamines 63-76 natriuretic peptide A Rattus norvegicus 27-30 2838252-12 1988 The data suggest that ANP secreted by adrenal medullary chromaffin cells may have distal paracrine actions or interactions with coreleased catecholamines and neuropeptides. Catecholamines 139-153 natriuretic peptide A Rattus norvegicus 22-25 2967888-0 1988 Bovine chromaffin cells have insulin-like growth factor-I (IGF-I) receptors: IGF-I enhances catecholamine secretion. Catecholamines 92-105 insulin like growth factor 1 Bos taurus 29-57 2967888-6 1988 Insulin was much less potent than IGF-I in enhancing catecholamine secretion. Catecholamines 53-66 insulin Bos taurus 0-7 2967888-0 1988 Bovine chromaffin cells have insulin-like growth factor-I (IGF-I) receptors: IGF-I enhances catecholamine secretion. Catecholamines 92-105 insulin like growth factor 1 Bos taurus 59-64 2967888-6 1988 Insulin was much less potent than IGF-I in enhancing catecholamine secretion. Catecholamines 53-66 insulin like growth factor 1 Bos taurus 34-39 2967888-0 1988 Bovine chromaffin cells have insulin-like growth factor-I (IGF-I) receptors: IGF-I enhances catecholamine secretion. Catecholamines 92-105 insulin like growth factor 1 Bos taurus 77-82 2905105-1 1988 In two groups of silver foxes--i.e. selected by the domestic type of behaviour and aggressive ones--studies have been made on the activity of the key enzyme in biosynthesis of catecholamines--i.e. tyrosine hydroxylase from the brain. Catecholamines 176-190 tyrosine hydroxylase Homo sapiens 197-217 3287952-2 1988 Our previous data indicated that changes in pancreatic islet hormones are not normally critical but decrements in insulin, increments in glucagon, or both become critical when catecholamine actions are blocked pharmacologically. Catecholamines 176-189 insulin Homo sapiens 114-121 2836401-8 1988 These data indicate that the catecholamine binding site is formed from the juxtaposition of span 7 and spans 3-5 in a tertiary structure probably similar to that of rhodopsin. Catecholamines 29-42 rhodopsin Meleagris gallopavo 165-174 3372503-1 1988 Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the synthesis of epinephrine from norepinephrine, the last step of catecholamine biosynthesis. Catecholamines 136-149 phenylethanolamine N-methyltransferase Homo sapiens 0-38 3372503-1 1988 Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the synthesis of epinephrine from norepinephrine, the last step of catecholamine biosynthesis. Catecholamines 136-149 phenylethanolamine N-methyltransferase Homo sapiens 40-44 3400098-9 1988 Since dopamine is inhibitory to PRL release from the adenohypophysis, increased ME steady-state concentrations and turnover of this catecholamine may be responsible for the decreased concentration of serum PRL detected within 4 hr of TCDD injection. Catecholamines 132-145 prolactin Rattus norvegicus 206-209 3409003-3 1988 The contribution of vascular monoamine oxidase (MAO) to the efficiency of the enzymatic blood-brain barrier (BBB) to catecholamines was assessed by measuring the multiregional cerebrovascular response to circulating NA given alone or after i.v. Catecholamines 117-131 monoamine oxidase A Rattus norvegicus 29-46 3409003-3 1988 The contribution of vascular monoamine oxidase (MAO) to the efficiency of the enzymatic blood-brain barrier (BBB) to catecholamines was assessed by measuring the multiregional cerebrovascular response to circulating NA given alone or after i.v. Catecholamines 117-131 monoamine oxidase A Rattus norvegicus 48-51 2898489-2 1988 Antisera against GABA-conjugates and the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), were localized within single sections by means of peroxidase-antiperoxidase (PAP) and immunoautoradiographic labeling methods. Catecholamines 41-54 tyrosine hydroxylase Rattus norvegicus 76-96 3409269-0 1988 Vasopressin and 1-deamino-8-D-arginine-vasopressin (DDAVP) reduce elevated plasma catecholamine levels in rats with hypothalamic deafferentation. Catecholamines 82-95 arginine vasopressin Rattus norvegicus 0-11 3409269-0 1988 Vasopressin and 1-deamino-8-D-arginine-vasopressin (DDAVP) reduce elevated plasma catecholamine levels in rats with hypothalamic deafferentation. Catecholamines 82-95 arginine vasopressin Rattus norvegicus 39-50 2902075-1 1988 Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis. Catecholamines 56-69 tyrosine hydroxylase Homo sapiens 0-20 2902075-1 1988 Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis. Catecholamines 56-69 tyrosine hydroxylase Homo sapiens 22-24 3290252-11 1988 Present and previous data in normal and alloxan-diabetic dogs, suggest that (a) in total insulin deficiency, control of hepatic glucose production during exercise is shifted from glucagon to catecholamines and that this may involve catecholamine-induced mobilization of peripheral substrates for gluconeogenesis and/or hepatic insensitivity to glucagon, and (b) insulin is not essential for a small exercise-induced increase in muscle glucose uptake, but normal insulin levels are required for the full response. Catecholamines 191-205 insulin Canis lupus familiaris 89-96 3389051-0 1988 Central effects of catecholamine antagonists on angiotensin-induced vasopressin secretion in conscious rats. Catecholamines 19-32 arginine vasopressin Rattus norvegicus 68-79 3290252-11 1988 Present and previous data in normal and alloxan-diabetic dogs, suggest that (a) in total insulin deficiency, control of hepatic glucose production during exercise is shifted from glucagon to catecholamines and that this may involve catecholamine-induced mobilization of peripheral substrates for gluconeogenesis and/or hepatic insensitivity to glucagon, and (b) insulin is not essential for a small exercise-induced increase in muscle glucose uptake, but normal insulin levels are required for the full response. Catecholamines 191-204 insulin Canis lupus familiaris 89-96 3290252-12 1988 Furthermore, the catecholamines appear to regulate muscle glucose uptake during exercise only when sufficient insulin is available to prevent markedly elevated FFA levels. Catecholamines 17-31 insulin Canis lupus familiaris 110-117 3373217-7 1988 The age-dependent changes in regulation and modification of NPY in adrenal glands and in specific brain areas may have physiological relevance in the regulation of catecholamine release from adrenal glands and some brain functions during aging. Catecholamines 164-177 neuropeptide Y Rattus norvegicus 60-63 2898127-1 1988 The gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (INS) and for the oncogene Harvey Ras 1 (HRAS). Catecholamines 17-30 tyrosine hydroxylase Homo sapiens 52-72 2898127-1 1988 The gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (INS) and for the oncogene Harvey Ras 1 (HRAS). Catecholamines 17-30 tyrosine hydroxylase Homo sapiens 74-76 2898127-1 1988 The gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (INS) and for the oncogene Harvey Ras 1 (HRAS). Catecholamines 17-30 insulin Homo sapiens 167-174 2898127-1 1988 The gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (INS) and for the oncogene Harvey Ras 1 (HRAS). Catecholamines 17-30 HRas proto-oncogene, GTPase Homo sapiens 202-214 2898127-1 1988 The gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (INS) and for the oncogene Harvey Ras 1 (HRAS). Catecholamines 17-30 HRas proto-oncogene, GTPase Homo sapiens 216-220 2835907-4 1988 In view of the present data and the importance of catechol estrogens in prostaglandin synthesis and in potentiating the activity of catecholamines through competitive inhibition of catechol-O-methyltransferase, it is suggested that catechol estrogens may play a role in triggering the events involved in the onset of labor and delivery in humans. Catecholamines 132-146 catechol-O-methyltransferase Homo sapiens 181-209 3399053-3 1988 Neurons in regions rich in catecholamines were positive for monoamine oxidase A, including the nucleus locus coeruleus, the nucleus subcoeruleus and the medullary reticular formation. Catecholamines 27-41 monoamine oxidase A Homo sapiens 60-79 3359794-2 1988 Hypoglycemia after resection of pheochromocytoma may be due to release of insulin from the beta cells of the pancreas due to sudden withdrawal of catecholamines. Catecholamines 146-160 insulin Homo sapiens 74-81 2906039-1 1988 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and a candidate gene for manic-depressive illness. Catecholamines 58-71 tyrosine hydroxylase Homo sapiens 0-20 2906039-1 1988 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and a candidate gene for manic-depressive illness. Catecholamines 58-71 tyrosine hydroxylase Homo sapiens 22-24 3402466-1 1988 Dopexamine hydrochloride (Dopacard) is a new synthetic catecholamine compound, which possesses potent beta 2-adrenergic and DA1-dopaminergic agonistic properties. Catecholamines 55-68 tropomyosin 2 Homo sapiens 124-127 3410377-10 1988 The results suggest that the lack from immature age of catecholamine and enkephalin which originate from the adrenal medulla appears to alter the responsiveness of the BP regulatory system to exogenous catecholamine and enkephalin in the rat. Catecholamines 55-68 proenkephalin Rattus norvegicus 220-230 2901738-2 1988 In order to obtain morphological evidence for such CA/NPY interactions in the arcuate nucleus, we have used a double immunostaining procedure using an anti-tyrosine hydroxylase (TH) antiserum as a marker for catecholamine neurons and an anti-NPY antiserum. Catecholamines 208-221 neuropeptide Y Rattus norvegicus 54-57 2901441-2 1988 In consecutive sections, tyrosine hydroxylase (TH) immunoreactivity was considered as a marker for catecholamine-synthesizing cells in general, while phenylethanolamine N-methyltransferase (PNMT) immunoreactivity was used as an indicator of adrenaline synthesis. Catecholamines 99-112 tyrosine hydroxylase Rattus norvegicus 25-45 2839012-6 1988 Catecholamines (epinephrine, norepinephrine and isoproterenol) reduced the basal secretion of ANP, whereas acetylcholine stimulated the release of ANP. Catecholamines 0-14 natriuretic peptide A Rattus norvegicus 94-97 3393697-9 1988 Corticotropin releasing factor (CRF), TRF and CGRP were the only peptides found to increase plasma catecholamine concentrations. Catecholamines 99-112 corticotropin releasing hormone Rattus norvegicus 0-30 3393697-9 1988 Corticotropin releasing factor (CRF), TRF and CGRP were the only peptides found to increase plasma catecholamine concentrations. Catecholamines 99-112 thyrotropin releasing hormone Rattus norvegicus 38-41 3393697-9 1988 Corticotropin releasing factor (CRF), TRF and CGRP were the only peptides found to increase plasma catecholamine concentrations. Catecholamines 99-112 calcitonin-related polypeptide alpha Rattus norvegicus 46-50 3133810-3 1988 Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA release by desmopressin. Catecholamines 107-120 chromosome 20 open reading frame 181 Homo sapiens 134-138 2966690-1 1988 The role of catecholamine in atrial natriuretic peptide (ANP) secretion and its secretory mechanism in normal humans is not well defined; therefore, we studied the relationship among ANP, catecholamine, and atrial pressures in 25 patients without cardiovascular disease and in 35 patients with chronic congestive heart failure (CHF, 20 in mitral valve disease and 15 in dilated cardiomyopathy). Catecholamines 12-25 natriuretic peptide A Homo sapiens 29-55 2966690-1 1988 The role of catecholamine in atrial natriuretic peptide (ANP) secretion and its secretory mechanism in normal humans is not well defined; therefore, we studied the relationship among ANP, catecholamine, and atrial pressures in 25 patients without cardiovascular disease and in 35 patients with chronic congestive heart failure (CHF, 20 in mitral valve disease and 15 in dilated cardiomyopathy). Catecholamines 12-25 natriuretic peptide A Homo sapiens 57-60 2901441-2 1988 In consecutive sections, tyrosine hydroxylase (TH) immunoreactivity was considered as a marker for catecholamine-synthesizing cells in general, while phenylethanolamine N-methyltransferase (PNMT) immunoreactivity was used as an indicator of adrenaline synthesis. Catecholamines 99-112 tyrosine hydroxylase Rattus norvegicus 47-49 2836245-1 1988 The possibility that catecholamines modulate the erythropoietin-induced increase in production of cyclic AMP was investigated by examining the effect of erythropoietin and/or L-isoprenaline on the activity of the plasma membrane adenylate cyclase of anaemic rabbit bone marrow erythroblasts. Catecholamines 21-35 erythropoietin Oryctolagus cuniculus 49-63 2898537-1 1988 Investigations into the structure and mechanisms regulating the expression of the genes involved in catecholamine biosynthesis have led to the isolation of a cDNA coding for bovine adrenal tyrosine hydroxylase (TH). Catecholamines 100-113 tyrosine hydroxylase Bos taurus 189-209 2898537-1 1988 Investigations into the structure and mechanisms regulating the expression of the genes involved in catecholamine biosynthesis have led to the isolation of a cDNA coding for bovine adrenal tyrosine hydroxylase (TH). Catecholamines 100-113 tyrosine hydroxylase Bos taurus 211-213 3345844-0 1988 Calmodulin- and protein phosphorylation-independent release of catecholamines from PC-12 cells. Catecholamines 63-77 calmodulin 1 Rattus norvegicus 0-10 3293227-1 1988 In this article we have reviewed available information characterizing an increase in SAS activity at birth, in the so-called "catecholamine surge." Catecholamines 126-139 tetraspanin 31 Homo sapiens 85-88 2833319-2 1988 In both groups, significant inverse correlations were observed when 24-hr urinary catecholamine levels were examined in relation to measures of both receptor-mediated (prostaglandin D2 and alpha 2-adrenergic) and postreceptor-mediated (NaF) platelet AC enzyme activities, suggesting that circulating catecholamines may regulate platelet AC by heterologous (agonist-nonspecific) desensitization of the AC enzyme complex. Catecholamines 82-95 C-X-C motif chemokine ligand 8 Homo sapiens 236-239 2833536-6 1988 In view of the known interactions of angiotensin II with both central and peripheral catecholamine-containing neurons of laboratory animals, the current anatomical findings suggest similar interactions between these neuroactive compounds in the human central nervous system. Catecholamines 85-98 angiotensinogen Homo sapiens 37-51 2896533-4 1988 Immunocytochemical staining for tyrosine hydroxylase, the rate-limiting enzyme for catecholamine synthesis, was used to identify and characterize the grafted cells. Catecholamines 83-96 tyrosine hydroxylase Rattus norvegicus 32-52 3351430-0 1988 Plasma levels of neuropeptide tyrosine Y (NPY) are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations. Catecholamines 140-153 neuropeptide Y Homo sapiens 17-40 3290078-2 1988 We have tested the role of the beta 2-sympathomimetic activity of the catecholamines in healthy volunteers. Catecholamines 70-84 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 31-37 3351430-0 1988 Plasma levels of neuropeptide tyrosine Y (NPY) are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations. Catecholamines 140-153 neuropeptide Y Homo sapiens 42-45 2831524-10 1988 The finding that beta 1-selective blockade significantly inhibits catecholamine-induced necrosis has possible broad clinical implications. Catecholamines 66-79 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 17-23 3348371-8 1988 The PAF infusions also induced dose-related increases in plasma glucagon and catecholamine levels throughout the infusion period. Catecholamines 77-90 PCNA clamp associated factor Rattus norvegicus 4-7 2895779-1 1988 Antibodies to the catecholamine synthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT) were used in an immunohistochemical analysis of the brain of the golden hamster. Catecholamines 18-31 dopamine beta-hydroxylase Mesocricetus auratus 104-107 2895779-1 1988 Antibodies to the catecholamine synthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT) were used in an immunohistochemical analysis of the brain of the golden hamster. Catecholamines 18-31 phenylethanolamine N-methyltransferase Mesocricetus auratus 154-158 3348792-2 1988 We report a direct demonstration and characterization of peptidyl alpha-amidating monooxygenase (PAM) activity in chromaffin granules, secretory vesicles long known as loci for synthesis and storage of catecholamines but only recently recognized as processing and storage sites for neuropeptides. Catecholamines 202-216 peptidylglycine alpha-amidating monooxygenase Homo sapiens 57-95 3348792-2 1988 We report a direct demonstration and characterization of peptidyl alpha-amidating monooxygenase (PAM) activity in chromaffin granules, secretory vesicles long known as loci for synthesis and storage of catecholamines but only recently recognized as processing and storage sites for neuropeptides. Catecholamines 202-216 peptidylglycine alpha-amidating monooxygenase Homo sapiens 97-100 3123488-0 1988 Vasoactive intestinal polypeptide and muscarine mobilize intracellular Ca2+ through breakdown of phosphoinositides to induce catecholamine secretion. Catecholamines 125-138 vasoactive intestinal peptide Rattus norvegicus 0-33 3123488-2 1988 We have recently shown that vasoactive intestinal polypeptide (VIP) is as potent as acetylcholine in inducing the secretion of catecholamines from the rat adrenal medulla. Catecholamines 127-141 vasoactive intestinal peptide Rattus norvegicus 28-61 3123488-2 1988 We have recently shown that vasoactive intestinal polypeptide (VIP) is as potent as acetylcholine in inducing the secretion of catecholamines from the rat adrenal medulla. Catecholamines 127-141 vasoactive intestinal peptide Rattus norvegicus 63-66 3123488-3 1988 In the present study we have investigated the molecular mechanism involved in the exocytotic secretion of catecholamines by VIP and the effects of VIP on Ca45 uptake and phosphoinositide breakdown and compared them with those of the classical cholinergic agonists. Catecholamines 106-120 vasoactive intestinal peptide Rattus norvegicus 124-127 3346832-0 1988 Neuropeptide Y inhibits the nicotine-mediated release of catecholamines from bovine adrenal chromaffin cells. Catecholamines 57-71 neuropeptide Y Bos taurus 0-14 2892747-4 1988 A population (approximately 70%) of the neurons showed positive immunocytochemistry for tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase, three enzymes in the pathway of catecholamine synthesis. Catecholamines 212-225 phenylethanolamine N-methyltransferase Homo sapiens 140-178 3342507-1 1988 Catechol-borate complexation and ion-pair formation combined with organic solvent extraction as preliminaries to radioenzymatic assay (REA) with catechol-O-methyltransferase-catalyzed methylation allows the quantification of catecholamines in plasma samples of any volume. Catecholamines 225-239 catechol-O-methyltransferase Homo sapiens 145-173 3335857-3 1988 Free Met-enkephalin immunoreactivity and total Met-enkephalin immunoreactivity, as determined by enzymatic digestion of large enkephalin-containing fragments, were coreleased with catecholamines. Catecholamines 180-194 proopiomelanocortin Homo sapiens 5-19 3335857-3 1988 Free Met-enkephalin immunoreactivity and total Met-enkephalin immunoreactivity, as determined by enzymatic digestion of large enkephalin-containing fragments, were coreleased with catecholamines. Catecholamines 180-194 proopiomelanocortin Homo sapiens 47-61 3346832-1 1988 The possible role of neuropeptide Y (NPY) in catecholamine secretion was studied by using bovine adrenal chromaffin cells. Catecholamines 45-58 neuropeptide Y Bos taurus 21-35 3346832-1 1988 The possible role of neuropeptide Y (NPY) in catecholamine secretion was studied by using bovine adrenal chromaffin cells. Catecholamines 45-58 neuropeptide Y Bos taurus 37-40 3346832-2 1988 NPY produced a concentration-dependent inhibition of nicotine-stimulated norepinephrine and epinephrine release from bovine chromaffin cells with IC50 (concentration of NPY which inhibits 50% of maximum release of catecholamines) values of 1.8 x 10(-9) M and 1.7 x 10(-9) M, respectively. Catecholamines 214-228 neuropeptide Y Bos taurus 0-3 3346832-2 1988 NPY produced a concentration-dependent inhibition of nicotine-stimulated norepinephrine and epinephrine release from bovine chromaffin cells with IC50 (concentration of NPY which inhibits 50% of maximum release of catecholamines) values of 1.8 x 10(-9) M and 1.7 x 10(-9) M, respectively. Catecholamines 214-228 neuropeptide Y Bos taurus 169-172 3346832-3 1988 Catecholamine release induced by 56 mM KCl was not inhibited by NPY at these concentrations but was inhibited by high concentration (2 x 10(-6) M) of NPY. Catecholamines 0-13 neuropeptide Y Bos taurus 150-153 3346832-7 1988 The rank order of potency of NPY and other structurally similar peptides to displace N-propionyl[3H]NPY from binding is human pancreatic polypeptide greater than or equal to NPY much greater than peptide YY greater than avian pancreatic polypeptide, and is correlated with their potency to inhibit catecholamine release. Catecholamines 298-311 neuropeptide Y Homo sapiens 29-32 3346832-8 1988 These results suggest a modulatory role for NPY through a specific NPY receptor in the secretion of catecholamine from the adrenal. Catecholamines 100-113 neuropeptide Y Bos taurus 44-47 3346832-8 1988 These results suggest a modulatory role for NPY through a specific NPY receptor in the secretion of catecholamine from the adrenal. Catecholamines 100-113 neuropeptide Y Bos taurus 67-70 3125946-0 1988 Depletion of central catecholamines reduces pressor responses to arginine vasopressin. Catecholamines 21-35 arginine vasopressin Rattus norvegicus 74-85 3342078-1 1988 Bovine adrenal medullary chromaffin cells, prelabeled with [3H]norepinephrine, released a large proportion of cellular 3H-labeled catecholamines (CAs) when stimulated with nicotine, K+, histamine, gamma-aminobutyric acid (GABA) and several peptidic hormones [bradykinin, angiotensin II, thyrotropin releasing hormone (TRH) and neurotensin]. Catecholamines 130-144 kininogen 1 Bos taurus 259-269 3342078-1 1988 Bovine adrenal medullary chromaffin cells, prelabeled with [3H]norepinephrine, released a large proportion of cellular 3H-labeled catecholamines (CAs) when stimulated with nicotine, K+, histamine, gamma-aminobutyric acid (GABA) and several peptidic hormones [bradykinin, angiotensin II, thyrotropin releasing hormone (TRH) and neurotensin]. Catecholamines 130-144 thyrotropin releasing hormone Bos taurus 271-316 3342078-1 1988 Bovine adrenal medullary chromaffin cells, prelabeled with [3H]norepinephrine, released a large proportion of cellular 3H-labeled catecholamines (CAs) when stimulated with nicotine, K+, histamine, gamma-aminobutyric acid (GABA) and several peptidic hormones [bradykinin, angiotensin II, thyrotropin releasing hormone (TRH) and neurotensin]. Catecholamines 146-149 kininogen 1 Bos taurus 259-269 3342078-1 1988 Bovine adrenal medullary chromaffin cells, prelabeled with [3H]norepinephrine, released a large proportion of cellular 3H-labeled catecholamines (CAs) when stimulated with nicotine, K+, histamine, gamma-aminobutyric acid (GABA) and several peptidic hormones [bradykinin, angiotensin II, thyrotropin releasing hormone (TRH) and neurotensin]. Catecholamines 146-149 thyrotropin releasing hormone Bos taurus 271-316 3125946-1 1988 Previous reports that central administration of arginine vasopressin (AVP) increases turnover of brain catecholamines raise the possibility that the pressor responses which follow central administration of AVP may be mediated, in part, by central catecholamines. Catecholamines 103-117 arginine vasopressin Rattus norvegicus 48-68 3125946-1 1988 Previous reports that central administration of arginine vasopressin (AVP) increases turnover of brain catecholamines raise the possibility that the pressor responses which follow central administration of AVP may be mediated, in part, by central catecholamines. Catecholamines 103-117 arginine vasopressin Rattus norvegicus 70-73 3125946-1 1988 Previous reports that central administration of arginine vasopressin (AVP) increases turnover of brain catecholamines raise the possibility that the pressor responses which follow central administration of AVP may be mediated, in part, by central catecholamines. Catecholamines 103-117 arginine vasopressin Rattus norvegicus 206-209 3125946-1 1988 Previous reports that central administration of arginine vasopressin (AVP) increases turnover of brain catecholamines raise the possibility that the pressor responses which follow central administration of AVP may be mediated, in part, by central catecholamines. Catecholamines 247-261 arginine vasopressin Rattus norvegicus 48-68 3125946-1 1988 Previous reports that central administration of arginine vasopressin (AVP) increases turnover of brain catecholamines raise the possibility that the pressor responses which follow central administration of AVP may be mediated, in part, by central catecholamines. Catecholamines 247-261 arginine vasopressin Rattus norvegicus 70-73 3125946-1 1988 Previous reports that central administration of arginine vasopressin (AVP) increases turnover of brain catecholamines raise the possibility that the pressor responses which follow central administration of AVP may be mediated, in part, by central catecholamines. Catecholamines 247-261 arginine vasopressin Rattus norvegicus 206-209 3125946-3 1988 Following a one week recovery, these conscious rats, fitted with indwelling arterial catheters, were given intraventricular injections of AVP; the increases in arterial pressure and heart rate were significantly reduced in the catecholamine-depleted animals. Catecholamines 227-240 arginine vasopressin Rattus norvegicus 138-141 3125946-4 1988 These data support the hypothesis that the pressor and tachycardia responses to intraventricular AVP are mediated, in part, by central catecholamine-containing neurons. Catecholamines 135-148 arginine vasopressin Rattus norvegicus 97-100 2903609-1 1988 The enzymes for synthesis of catecholamine, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT), have been immunocytochemically localized in the guinea pig cochlea. Catecholamines 29-42 phenylethanolamine N-methyltransferase Cavia porcellus 149-153 2967028-5 1988 The augmented ANP levels during exercise after beta-blockade probably reflect catecholamine-stimulated ANP release, whereas the elevated plasma ANP levels after acebutolol at rest might be a beta-adrenoceptor-mediated ANP release due to the intrinsic sympathomimetic effect of acebutolol. Catecholamines 78-91 natriuretic peptide A Homo sapiens 14-17 2967028-5 1988 The augmented ANP levels during exercise after beta-blockade probably reflect catecholamine-stimulated ANP release, whereas the elevated plasma ANP levels after acebutolol at rest might be a beta-adrenoceptor-mediated ANP release due to the intrinsic sympathomimetic effect of acebutolol. Catecholamines 78-91 natriuretic peptide A Homo sapiens 103-106 2967028-5 1988 The augmented ANP levels during exercise after beta-blockade probably reflect catecholamine-stimulated ANP release, whereas the elevated plasma ANP levels after acebutolol at rest might be a beta-adrenoceptor-mediated ANP release due to the intrinsic sympathomimetic effect of acebutolol. Catecholamines 78-91 natriuretic peptide A Homo sapiens 103-106 2967028-5 1988 The augmented ANP levels during exercise after beta-blockade probably reflect catecholamine-stimulated ANP release, whereas the elevated plasma ANP levels after acebutolol at rest might be a beta-adrenoceptor-mediated ANP release due to the intrinsic sympathomimetic effect of acebutolol. Catecholamines 78-91 natriuretic peptide A Homo sapiens 103-106 2903607-2 1988 An esthesioneuroblastoma in a 16-year-old male was studied ultrastructurally and immunohistochemically, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme in the catecholamine-synthesizing pathway. Catecholamines 185-198 tyrosine hydroxylase Homo sapiens 128-148 2903607-2 1988 An esthesioneuroblastoma in a 16-year-old male was studied ultrastructurally and immunohistochemically, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme in the catecholamine-synthesizing pathway. Catecholamines 185-198 tyrosine hydroxylase Homo sapiens 150-152 2903609-1 1988 The enzymes for synthesis of catecholamine, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT), have been immunocytochemically localized in the guinea pig cochlea. Catecholamines 29-42 dopamine beta-hydroxylase Cavia porcellus 71-96 2897199-4 1988 A unilateral nephrectomy increased the activity of TH in the midmedulla, a brain region important in the baroreflex regulation of blood pressure, and in the adrenal gland, the major source of circulating catecholamines. Catecholamines 204-218 LOC100008895 Oryctolagus cuniculus 51-53 2852023-4 1988 Regulation of cAMP levels by glucagon, insulin, and catecholamines accounts in large part for minute-to-minute hormonal control of pathway flux in fed animals and during the transition from fed to starved; second, cAMP plays a key role in regulation of gene transcription of phosphoenolpyruvate carboxykinase, pyruvate kinase, glucokinase, and probably 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Catecholamines 52-66 glucokinase Homo sapiens 327-338 3202543-10 1988 Furthermore, intracerebroventricular (ICV) injection of corticotropin-releasing factor (CRF) produces stresslike increases in DOPAC and MHPG concentrations, suggesting that the release of CRF in the brain during stress may mediate the changes in catecholamine metabolism. Catecholamines 246-259 corticotropin releasing hormone Mus musculus 56-86 2462417-1 1988 Two structurally related tetrapeptides, the N-terminal tetrapeptide of substance P SP(1-4) and tuftsin, exerted some similarities in modifying immune reactions and normalizing stress-induced disorders in the catecholamine system of adrenals. Catecholamines 208-221 Sp4 transcription factor Rattus norvegicus 83-89 2852942-3 1988 The level of circulating catecholamines (epinephrine, norepinephrine) was significantly higher in patients were severe HF, which probably caused more evident decrease in lymphocyte beta 2-adrenoceptors density in these patients. Catecholamines 25-39 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 181-187 3129982-3 1988 Mechanisms of bioactivation by MAO-B of MPTP to MPP+, concentration of MPP+ in neurons with a catecholamine uptake system, and vulnerability to cellular toxic effects of MPP+ are the basis for the specificity of MPTP targeting of nigrostriatal dopaminergic neurons. Catecholamines 94-107 monoamine oxidase B Homo sapiens 31-36 2894872-0 1988 Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. Catecholamines 0-14 hemoglobin, beta adult minor chain Mus musculus 92-98 2901019-9 1988 A role of catecholamines in mediating MS-stimulated ANP release is supported by the observation that ganglionic blockade with chlorisondamine significantly attenuated the increase of plasma ANP levels. Catecholamines 10-24 natriuretic peptide A Rattus norvegicus 52-55 2848631-4 1988 Accordingly, NPY displays a wide variety of functional activities depending on its location and coexistence with other substances, especially catecholamines. Catecholamines 142-156 neuropeptide Y Homo sapiens 13-16 2848631-5 1988 NPY exerts direct effects at several targets and also modulates the cellular response to catecholamines and to peptides such as LHRH. Catecholamines 89-103 neuropeptide Y Homo sapiens 0-3 2848631-6 1988 It is reasonable to expect that NPY will modulate the pre- and postjunctional effects of catecholamines at many of their targets in view of the distribution of NPY in central catecholaminergic neurons and throughout the preaortic and sympathetic chain ganglia. Catecholamines 89-103 neuropeptide Y Homo sapiens 32-35 3162891-2 1988 The thermolabile (TL) form of the enzyme phenol sulfotransferase (PST) catalyzes the sulfation of catecholamine neurotransmitters and drugs such as methyldopa and acetaminophen. Catecholamines 98-111 sulfotransferase family 1A member 1 Homo sapiens 41-64 3162891-2 1988 The thermolabile (TL) form of the enzyme phenol sulfotransferase (PST) catalyzes the sulfation of catecholamine neurotransmitters and drugs such as methyldopa and acetaminophen. Catecholamines 98-111 sulfotransferase family 1A member 1 Homo sapiens 66-69 2832354-1 1988 Neuronal spherical bodies, rich in arginine, of catecholamine neurons in man display staining reactions of mitotic chromosomes and myelin basic protein. Catecholamines 48-61 myelin basic protein Homo sapiens 131-151 2901019-9 1988 A role of catecholamines in mediating MS-stimulated ANP release is supported by the observation that ganglionic blockade with chlorisondamine significantly attenuated the increase of plasma ANP levels. Catecholamines 10-24 natriuretic peptide A Rattus norvegicus 190-193 3285225-6 1988 An increase in circulating plasma catecholamine concentrations appeared to mediate yohimbine-induced renin release since propranolol prevented the rise in PRA caused by yohimbine in renal denervated rats. Catecholamines 34-47 renin Rattus norvegicus 101-106 3336349-1 1988 The catecholamine uptake inhibitor tetrabenazine (TBZ) binds to a high affinity site on the chromaffin granule membrane, presumably on the monoamine transporter. Catecholamines 4-17 solute carrier family 18 member A2 Homo sapiens 139-160 2856652-3 1988 Administration of TRH to experimental animals or human subjects induces pressor and tachycardic responses and increases plasma levels of catecholamines. Catecholamines 137-151 thyrotropin releasing hormone Homo sapiens 18-21 3443096-8 1987 Comparative amino acid sequence analysis establishes that DBH shares no homology with the other catecholamine synthesizing enzymes, tyrosine hydroxylase and phenylethanolamine-N-methyl transferase. Catecholamines 96-109 dopamine beta-hydroxylase Homo sapiens 58-61 2897090-4 1988 Furthermore these catecholamine neurons exhibited immunoreactivity for an adrenaline-synthesizing enzyme, phenylethanolamine N-methyltransferase. Catecholamines 18-31 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-144 3406005-9 1988 N-myc amplification may correlate with immaturity of catecholamine metabolism of neuroblastoma. Catecholamines 53-66 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 0-5 2961244-7 1987 Recent evidence suggests that the myc proto-oncogene is activated in cells undergoing catecholamine-induced hypertrophy and our laboratory has detected activation of the sis proto-oncogene in at least 1 model of left ventricular hypertrophy. Catecholamines 86-99 MYC proto-oncogene, bHLH transcription factor Canis lupus familiaris 34-37 3440206-5 1987 In E13 explants, immunoreactivity to both PNMT and tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis, was observed. Catecholamines 101-114 phenylethanolamine-N-methyltransferase Rattus norvegicus 42-46 2890712-7 1987 These results suggest that removal of extracellular Na+ increases the synthesis of catecholamines, at least in part, by shifting the intracellular pH toward the optimal pH of tyrosine hydroxylase. Catecholamines 83-97 tyrosine hydroxylase Bos taurus 175-195 2450185-6 1987 Vascular tone is maintained to a substantial degree by the stimulation of alpha-adrenoceptors (both alpha 1 and alpha 2) by circulating and neuronally released catecholamines, and probably also by ANG II in the vascular wall. Catecholamines 160-174 adrenoceptor alpha 1D Homo sapiens 100-119 3681297-4 1987 Co-release of 7B2 with catecholamine induced by nicotine from the cultured bovine chromaffin cells was also observed. Catecholamines 23-36 secretogranin V Bos taurus 14-17 2963188-8 1987 The low correlation suggests a weak relationship between beta-endorphin and catecholamine responses during exercise. Catecholamines 76-89 proopiomelanocortin Homo sapiens 57-71 3681297-8 1987 The possibility that 7B2 might be released with catecholamine, possibly in response to stress, warrants investigation. Catecholamines 48-61 secretogranin V Bos taurus 21-24 3319049-5 1987 The majority of PNMT containing cells in the brainstem/medulla appear to also contain other catecholamine biosynthetic enzymes. Catecholamines 92-105 phenylethanolamine-N-methyltransferase Rattus norvegicus 16-20 3437997-1 1987 The distribution of catecholaminergic cells in the human pons and medulla was illustrated by immunocytochemistry using a polyclonal antibody directed against the catecholamine synthetic enzyme, dopamine-beta-hydroxylase. Catecholamines 20-33 dopamine beta-hydroxylase Homo sapiens 194-219 3318505-9 1987 Circulating catecholamines influence the release of vasopressin by alpha- and beta-adrenergic pathways. Catecholamines 12-26 arginine vasopressin Homo sapiens 52-63 2448038-2 1987 Islet cells also contain two enzymes of the catecholamine biosynthetic pathway : tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC). Catecholamines 44-57 dopa decarboxylase Mus musculus 111-146 2448038-2 1987 Islet cells also contain two enzymes of the catecholamine biosynthetic pathway : tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC). Catecholamines 44-57 dopa decarboxylase Mus musculus 148-152 2887276-1 1987 A parietal lobe ganglioglioma in a 2-year-old girl was investigated ultrastructurally and immunohistochemically, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme of the catecholamine (CA)-synthesizing pathway. Catecholamines 194-207 tyrosine hydroxylase Homo sapiens 137-157 2890720-3 1987 However, in the presence of NGF, it stimulates neuronal metabolism and catecholamine (CA), but not ACh production by the SCG neurons. Catecholamines 71-84 nerve growth factor Gallus gallus 28-31 2890079-4 1987 Two to 4 weeks after surgery the responsiveness of their catecholaminergic neurons was tested by an injection of human beta-endorphin (20 micrograms/kg); it caused a rise in portal catecholamine levels equivalent to that seen in intact dogs. Catecholamines 57-70 proopiomelanocortin Homo sapiens 119-133 2890079-5 1987 Then the effect of a spike concentration of SRIF or GH on hepatic portal and peripheral levels of free serotonin and catecholamines was studied, all by radioenzymatic methods. Catecholamines 117-131 somatotropin Canis lupus familiaris 52-54 2825170-8 1987 Expression of receptor protein in Xenopus laevis oocytes conveys adenylate cyclase responsiveness to catecholamines with a typical beta 1AR specificity. Catecholamines 101-115 adrenoceptor beta 1 Homo sapiens 131-139 2887276-1 1987 A parietal lobe ganglioglioma in a 2-year-old girl was investigated ultrastructurally and immunohistochemically, using antiserum against tyrosine hydroxylase (TH), a rate-limiting enzyme of the catecholamine (CA)-synthesizing pathway. Catecholamines 194-207 tyrosine hydroxylase Homo sapiens 159-161 3317527-6 1987 These results demonstrate that NPY, which is colocalized with catecholamines in the peripheral nervous systems, is also released during stress responses and that its release parallels more closely changes in circulating NA than AD. Catecholamines 62-76 neuropeptide Y Rattus norvegicus 31-34 3441159-1 1987 An analytical technique based on HPLC and electrochemical detection was developed for assay of free catecholamines in CSF. Catecholamines 100-114 colony stimulating factor 2 Homo sapiens 118-121 2889789-10 1987 It is concluded that the increases in plasma CaBP induced by either ACTH or alpha 2-adrenergic stimulation may be interrelated since the administration of ACTH can lead to raised plasma concentrations of catecholamines. Catecholamines 204-218 S100 calcium binding protein G Sus scrofa 45-49 3675477-2 1987 The specific feature of adaptation to this exposure is the transition to a new level of hormonal regulation with a significant increase of the content (production) of glucocorticoids, catecholamines, components of the renin-angiotensin-aldosterone system, which determines a modified activity of tissue hormones, and fluid-electrolyte homeostasis, as well as simultaneous increase of insulin secretion that diminishes the metabolic effects of glucocorticoids and catecholamines. Catecholamines 463-477 renin Homo sapiens 218-223 2889453-0 1987 Regulation of nerve growth factor synthesis/secretion by catecholamine in cultured mouse astroglial cells. Catecholamines 57-70 nerve growth factor Mus musculus 14-33 2889453-1 1987 The nerve growth factor (NGF) synthesis/secretion by cultured mouse astroglial cells was modulated by catecholamine. Catecholamines 102-115 nerve growth factor Mus musculus 4-23 2889453-1 1987 The nerve growth factor (NGF) synthesis/secretion by cultured mouse astroglial cells was modulated by catecholamine. Catecholamines 102-115 nerve growth factor Mus musculus 25-28 2889453-6 1987 These results suggest that catecholamine is one of the molecules responsible for regulation of NGF synthesis/secretion in the mouse brain. Catecholamines 27-40 nerve growth factor Mus musculus 95-98 2887885-0 1987 Reduction of stress/catecholamine-induced cardiac necrosis by beta 1-selective blockade. Catecholamines 20-33 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 62-68 3678363-5 1987 These findings indicate that both anoxia coupled with glucose deprivation and ischemia inhibit both uptake2 and COMT activity and suggest that such inhibition may be responsible for the high concentration of catecholamines released locally following myocardial infarction. Catecholamines 208-222 catechol-O-methyltransferase Rattus norvegicus 112-116 2822768-0 1987 Effects of catecholamines on secretion of adrenocorticotrophic hormone (ACTH) in man. Catecholamines 11-25 proopiomelanocortin Homo sapiens 72-76 2892697-1 1987 The hyperpolarization of the secretory cells MP and the alveolar myoepithelium contraction in response to oxytocin depend to a greater extent on the accompanying effects of catecholamines as compared with acetylcholine. Catecholamines 173-187 oxytocin/neurophysin I prepropeptide Homo sapiens 106-114 2887643-1 1987 The synaptic organization of dopamine-containing amacrine cells in the rhesus monkey retina was studied using immunohistochemistry of tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine synthetic pathway. Catecholamines 193-206 tyrosine hydroxylase Macaca mulatta 156-158 3040005-4 1987 These results raise the possibility that cGMP accumulation in other tissues might be regulated by VIP, and that the stimulating effects of VIP might be markedly amplified by catecholamine transmitters in these tissues. Catecholamines 174-187 vasoactive intestinal peptide Rattus norvegicus 139-142 3118145-0 1987 The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism. Catecholamines 150-163 alpha methyl dopa-resistant Drosophila melanogaster 4-21 3118145-1 1987 The dopa decarboxylase gene (Ddc) is located in a very dense cluster of genes many of whose functions appear to be related to the physiological role of dopa decarboxylase (DDC) in catecholamine metabolism. Catecholamines 180-193 Dopa decarboxylase Drosophila melanogaster 4-22 3118145-1 1987 The dopa decarboxylase gene (Ddc) is located in a very dense cluster of genes many of whose functions appear to be related to the physiological role of dopa decarboxylase (DDC) in catecholamine metabolism. Catecholamines 180-193 Dopa decarboxylase Drosophila melanogaster 29-32 3118145-1 1987 The dopa decarboxylase gene (Ddc) is located in a very dense cluster of genes many of whose functions appear to be related to the physiological role of dopa decarboxylase (DDC) in catecholamine metabolism. Catecholamines 180-193 Dopa decarboxylase Drosophila melanogaster 152-170 3118145-1 1987 The dopa decarboxylase gene (Ddc) is located in a very dense cluster of genes many of whose functions appear to be related to the physiological role of dopa decarboxylase (DDC) in catecholamine metabolism. Catecholamines 180-193 Dopa decarboxylase Drosophila melanogaster 172-175 2887168-1 1987 Tyrosine hydroxylase, the rate-limiting enzyme in the biosynthesis of catecholamines, was reversibly inactivated by incubation with antipain, which is known as a microbial protease inhibitor. Catecholamines 70-84 tyrosine hydroxylase Homo sapiens 0-20 3308808-3 1987 Control lambs exhibited peak (means +/- SE) increases above fetal base line at 5 min after birth in plasma renin activity (5.0 +/- 1.1 to 11.0 +/- 3.4 ng.ml-1.h-1), angiotensin II (ANG II, 37 +/- 6 to 141 +/- 45 pg/ml) and total catecholamines (318 +/- 35 to 3,821 +/- 580 pg/ml). Catecholamines 229-243 renin Ovis aries 107-112 3497586-0 1987 Comparison of corticotropin-releasing factor and acetylcholine on catecholamine secretion in dogs. Catecholamines 66-79 corticotropin releasing hormone Canis lupus familiaris 14-44 3497586-1 1987 To test whether corticotropin-releasing factor (CRF) is a secretagogue for adrenal secretion of catecholamines, a preparation was developed that permits measurement of adrenal venous output in response to in vivo arterial injection into the dog adrenal gland. Catecholamines 96-110 corticotropin releasing hormone Canis lupus familiaris 16-46 2444242-9 1987 PLAP activity could be modulated by a concerted action of either butyrate plus retinoic acid or butyrate plus catecholamines or histamine, indicating a possible role for PLAP in tumour cell proliferation. Catecholamines 110-124 alkaline phosphatase, placental Homo sapiens 0-4 2887332-7 1987 It is suggested that increased right atrial pressure and/or pulmonary arterial blood pressure and increased plasma levels of catecholamines are important secretory stimuli for ANP during exercise. Catecholamines 125-139 natriuretic peptide A Homo sapiens 176-179 2822559-5 1987 PYY further elicited specific changes in plasma catecholamine concentrations, i.e. an increase of NE but not of E, which were in contrast to the effects of insulin-induced hypoglycemia. Catecholamines 48-61 peptide YY Canis lupus familiaris 0-3 2887117-7 1987 Similarly, depletion of tissue catecholamines by pretreatment with 6-OH dopamine, reserpine, or celiac ganglionectomy together with vagal section abolished the effect of CCK-8. Catecholamines 31-45 cholecystokinin Rattus norvegicus 170-173 2444242-0 1987 Modulation of placental alkaline phosphatase activity and cytokeratins in human HN-1 cells by butyrate, retinoic acid, catecholamines and histamine. Catecholamines 119-133 alkaline phosphatase, placental Homo sapiens 14-44 2444242-5 1987 A synergistic enhancement of PLAP activity was demonstrated after treatment of butyrate pretreated cells with catecholamines or histamine. Catecholamines 110-124 alkaline phosphatase, placental Homo sapiens 29-33 3315149-6 1987 The scientific data available is inconclusive but there is significant hope of retarding progressive catecholaminergic neuron degenerative changes by augmenting the free radical scavenging system with antioxidants (such as Vitamin E) and slowing catecholamine oxidation by monoamine oxidase B inhibition. Catecholamines 101-114 monoamine oxidase B Homo sapiens 273-292 2822559-0 1987 Biological actions of peptide YY: effects on endocrine pancreas, pituitary-adrenal axis, and plasma catecholamine concentrations in the dog. Catecholamines 100-113 peptide YY Canis lupus familiaris 22-32 2889817-1 1987 The locus of the structural gene encoding tyrosine hydroxylase, Th, the rate limiting enzyme for catecholamine biosynthesis, was mapped to the distal end of mouse Chromosome (Chr) 7. Catecholamines 97-110 tyrosine hydroxylase Mus musculus 42-62 3683592-6 1987 The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline. Catecholamines 30-44 catechol-O-methyltransferase Rattus norvegicus 5-9 3683592-6 1987 The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline. Catecholamines 176-190 catechol-O-methyltransferase Rattus norvegicus 5-9 3039336-3 1987 BAR was compared to the catecholamine biosynthetic enzyme dopamine B-hydroxylase (DBH) by anti-BAR antibody cross-reactivity. Catecholamines 24-37 dopamine beta-hydroxylase Bos taurus 82-85 3039336-11 1987 These results suggest that the catecholamine biosynthetic enzyme DBH and BAR may be related in structure. Catecholamines 31-44 dopamine beta-hydroxylase Bos taurus 65-68 3683592-7 1987 The extraneuronal MAO activity was low for all three catecholamines, (-)-adrenaline, (-)-noradrenaline and dopamine (range of kMAO from 0.05 to 0.28 min-1) and declined in the order. Catecholamines 53-67 monoamine oxidase A Rattus norvegicus 18-21 2822014-11 1987 These results suggest that the alteration in the insulin-receptor tyrosine kinase activity induced by cyclic AMP-dependent protein kinase could contribute to the insulin resistance produced by catecholamines. Catecholamines 193-207 insulin receptor Mus musculus 49-65 2819759-0 1987 The corticotropin-releasing factor release in rat hypophysial portal blood is mediated by brain catecholamines. Catecholamines 96-110 corticotropin releasing hormone Rattus norvegicus 4-34 2819759-1 1987 In order to study the involvement of the hypothalamic corticotropin-releasing factor (CRF) in catecholamine-induced adrenocorticotropin (ACTH) secretion, we have measured CRF levels in rat hypophysial portal blood (HPB) after the pharmacological destruction of the ventral noradrenergic bundle (VNAB), using 6-hydroxydopamine (6-OHDA) stereotaxically injected into the VNAB. Catecholamines 94-107 corticotropin releasing hormone Rattus norvegicus 54-84 2440918-4 1987 Galanin immunoreactivity was found to coexist with dopamine-beta-hydroxylase (DBH) immunoreactivity in subsets of retrogradely labeled neurons of the A1 and A6 (locus coeruleus) catecholamine cell groups; no evidence was adduced for the presence of galanin in adrenergic (i.e., phenylethanolamine-N-methyltransferase-positive) neurons that project to the PVH. Catecholamines 178-191 dopamine beta-hydroxylase Rattus norvegicus 51-76 3036595-0 1987 Catecholamine inhibition of Ca2+-induced insulin secretion from electrically permeabilised islets of Langerhans. Catecholamines 0-13 insulin Homo sapiens 41-48 3656194-0 1987 Vasoactive intestinal polypeptide stimulates the secretion of catecholamines from the rat adrenal gland. Catecholamines 62-76 vasoactive intestinal peptide Rattus norvegicus 0-33 2820811-6 1987 Catecholamine and phorbol ester induced insulin resistance of isolated rat fat cells as well as human fat cells was associated with a decreased activity of the insulin receptor tyrosine kinase which was apparently due to a modulation of the ATP binding site of the insulin receptor tyrosine kinase; 3. Catecholamines 0-13 insulin Homo sapiens 40-47 2820811-6 1987 Catecholamine and phorbol ester induced insulin resistance of isolated rat fat cells as well as human fat cells was associated with a decreased activity of the insulin receptor tyrosine kinase which was apparently due to a modulation of the ATP binding site of the insulin receptor tyrosine kinase; 3. Catecholamines 0-13 insulin Homo sapiens 160-167 2820811-6 1987 Catecholamine and phorbol ester induced insulin resistance of isolated rat fat cells as well as human fat cells was associated with a decreased activity of the insulin receptor tyrosine kinase which was apparently due to a modulation of the ATP binding site of the insulin receptor tyrosine kinase; 3. Catecholamines 0-13 insulin Homo sapiens 160-167 3585342-6 1987 Chrg A release on nicotinic stimulation is blocked by D-600 and hexamethonium to the same extent as Met-enkephalin and catecholamine release. Catecholamines 119-132 chromogranin A Bos taurus 0-6 2884275-5 1987 The effect of CNTF on catecholamine storage was not accompanied by changes in the activities of TH and PNMT. Catecholamines 22-35 ciliary neurotrophic factor Rattus norvegicus 14-18 2442631-3 1987 The inhibition of glucose transport induced by lipolytic hormones such as glucagon, catecholamines or ACTH in the presence of adenosine deaminase was antagonized by PGE2. Catecholamines 84-98 adenosine deaminase Rattus norvegicus 126-145 3656194-10 1987 0.3 microM-VIP caused a significant increase in the secretion of catecholamines, and the effect increased with an increase in the concentration of VIP. Catecholamines 65-79 vasoactive intestinal peptide Rattus norvegicus 11-14 3656194-10 1987 0.3 microM-VIP caused a significant increase in the secretion of catecholamines, and the effect increased with an increase in the concentration of VIP. Catecholamines 65-79 vasoactive intestinal peptide Rattus norvegicus 147-150 3656194-11 1987 About 115 ng of catecholamines were secreted during 15 min perfusion with 3 microM-VIP. Catecholamines 16-30 vasoactive intestinal peptide Rattus norvegicus 83-86 3656194-18 1987 It is suggested that VIP may be the non-cholinergic excitatory substance present in the splanchnic nerves and released along with acetylcholine during simulation of the nerves to evoke secretion of catecholamine from the rat chromaffin cells. Catecholamines 198-211 vasoactive intestinal peptide Rattus norvegicus 21-24 3601235-1 1987 Neuropeptide Y (NPY) is a 36-amino acid peptide found co-localised with catecholamines in many sympathetic postganglionic nerves. Catecholamines 72-86 neuropeptide Y Canis lupus familiaris 0-14 3306452-2 1987 Immunocytochemical studies using this antibody have demonstrated that cytochrome b561 is present in many neural and endocrine tissues and that its distribution is correlated with the presence of either catecholamines or amidated peptides in the tissue. Catecholamines 202-216 mitochondrially encoded cytochrome b Homo sapiens 70-82 2889157-5 1987 The "selective" noradrenergic neurotoxin DSP4 caused an initial increase in the release of both catecholamines, followed by a marked decrease in their release. Catecholamines 96-110 dual specificity phosphatase 26 Homo sapiens 41-45 3601235-1 1987 Neuropeptide Y (NPY) is a 36-amino acid peptide found co-localised with catecholamines in many sympathetic postganglionic nerves. Catecholamines 72-86 neuropeptide Y Canis lupus familiaris 16-19 3591967-1 1987 We studied whether adrenal medullary catecholamines (CAs) contribute to the metabolically linked increase in regional cerebral blood flow (rCBF) elicited by electrical stimulation of the dorsal medullary reticular formation (DMRF). Catecholamines 53-56 CCAAT/enhancer binding protein zeta Rattus norvegicus 139-143 2954451-1 1987 The role of atrial pressure and catecholamines in secreting human atrial natriuretic polypeptides (hANP) were investigated in patients with acute or old myocardial infarction (AMI or OMI). Catecholamines 32-46 natriuretic peptide A Homo sapiens 99-103 2954451-4 1987 In 12 patients with OMI, plasma hANP levels were normal at rest and were significantly increased (p less than 0.01) with bicycle ergometer exercise associated with significant elevations of plasma catecholamine levels, mRA, and PCW. Catecholamines 197-210 natriuretic peptide A Homo sapiens 32-36 3591934-1 1987 In this study we have examined the actions of angiotensin II (ANG II) on catecholamine metabolism in neuronal brain cell cultures prepared from the hypothalamus and brain stem. Catecholamines 73-86 angiotensinogen Rattus norvegicus 46-60 3591934-1 1987 In this study we have examined the actions of angiotensin II (ANG II) on catecholamine metabolism in neuronal brain cell cultures prepared from the hypothalamus and brain stem. Catecholamines 73-86 angiotensinogen Rattus norvegicus 62-68 2955256-2 1987 ANF was found to inhibit the carbachol-stimulated synthesis of catecholamines from their labelled [3H]tyrosine precursor in an organ suspension of the rat superior cervical ganglia in vitro. Catecholamines 63-77 natriuretic peptide A Rattus norvegicus 0-3 3591967-1 1987 We studied whether adrenal medullary catecholamines (CAs) contribute to the metabolically linked increase in regional cerebral blood flow (rCBF) elicited by electrical stimulation of the dorsal medullary reticular formation (DMRF). Catecholamines 37-51 CCAAT/enhancer binding protein zeta Rattus norvegicus 139-143 3036704-4 1987 ANG II receptors were found to be concentrated in the rostral and caudal ventrolateral medulla, which corresponded to the region of C1 and A1 catecholamine-containing cell groups in the rabbit. Catecholamines 142-155 angiotensinogen Rattus norvegicus 0-6 2884153-1 1987 We have previously reported that cells transiently expressing tyrosine hydroxylase (TH), the first enzyme of the catecholamine biosynthetic pathway, are present in the pancreas of mouse embryos from prenatal Day 11 (E11) and that, at E12, some TH cells contain glucagon. Catecholamines 113-126 tyrosine hydroxylase Mus musculus 62-82 2884153-1 1987 We have previously reported that cells transiently expressing tyrosine hydroxylase (TH), the first enzyme of the catecholamine biosynthetic pathway, are present in the pancreas of mouse embryos from prenatal Day 11 (E11) and that, at E12, some TH cells contain glucagon. Catecholamines 113-126 tyrosine hydroxylase Mus musculus 84-86 2955256-0 1987 Atrial natriuretic factor partially inhibits the stimulated catecholamine synthesis in superior cervical ganglia of the rat. Catecholamines 60-73 natriuretic peptide A Rattus norvegicus 0-25 2883870-4 1987 Thus, beta 1 adrenoceptors may be considered as physiologically innervated receptors mediating responses to neuronally released norepinephrine, and beta 2 receptors as mediating responses to circulating catecholamines, particularly epinephrine. Catecholamines 203-217 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 6-12 2883870-4 1987 Thus, beta 1 adrenoceptors may be considered as physiologically innervated receptors mediating responses to neuronally released norepinephrine, and beta 2 receptors as mediating responses to circulating catecholamines, particularly epinephrine. Catecholamines 203-217 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 148-154 3033416-1 1987 Catecholamines and GABA are neurotransmitters involved in the regulation of release of pro-opiomelanocortin (POMC) derived peptides from the neurointermediate lobe of Xenopus laevis. Catecholamines 0-14 proopiomelanocortin L homeolog Xenopus laevis 87-107 3033416-1 1987 Catecholamines and GABA are neurotransmitters involved in the regulation of release of pro-opiomelanocortin (POMC) derived peptides from the neurointermediate lobe of Xenopus laevis. Catecholamines 0-14 proopiomelanocortin L homeolog Xenopus laevis 109-113 3109862-6 1987 Peak and integrated cortisol, GH, and catecholamine responses to insulin and proinsulin were similar, but those of prolactin were reduced after proinsulin when compared with insulin by 42% (P less than .01) and 34% (P less than .05), respectively. Catecholamines 38-51 insulin Homo sapiens 65-72 3107575-2 1987 This stimulatory effect of VIP on 14C-catecholamine synthesis was not dependent upon extracellular Ca2+. Catecholamines 38-51 vasoactive intestinal peptide Bos taurus 27-30 3107575-5 1987 These results suggested that VIP stimulated catecholamine synthesis by activation of tyrosine hydroxylase and that protein kinase C was involved in this stimulatory mechanism. Catecholamines 44-57 vasoactive intestinal peptide Bos taurus 29-32 3109862-0 1987 Differential effects of insulin- and proinsulin-induced hypoglycemia on pituitary hormone and catecholamine secretion. Catecholamines 94-107 insulin Homo sapiens 24-47 3107575-0 1987 Stimulation by vasoactive intestinal polypeptide of catecholamine synthesis in isolated bovine adrenal chromaffin cells. Catecholamines 52-65 vasoactive intestinal peptide Bos taurus 15-48 3555831-1 1987 The distribution of catecholamine synthesizing enzymes within the paraventricular nucleus of the rat hypothalamus is elucidated immunocytochemically by use of antibodies to tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine-N-methyltransferase. Catecholamines 20-33 tyrosine hydroxylase Rattus norvegicus 173-193 3555831-1 1987 The distribution of catecholamine synthesizing enzymes within the paraventricular nucleus of the rat hypothalamus is elucidated immunocytochemically by use of antibodies to tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine-N-methyltransferase. Catecholamines 20-33 phenylethanolamine-N-methyltransferase Rattus norvegicus 226-264 3585105-6 1987 Catecholamine-stimulated activity was significantly low and prostaglandin-stimulated activity was significantly high in rabbit endometrium after hCG treatment. Catecholamines 0-13 hypertrichosis 2 (generalised, congenital) Homo sapiens 145-148 3613758-5 1987 The AT II effects were increased by the DAergic agonists apomorphine and nomifensine and were decreased by the DAergic antagonist haloperidol and by the inhibitor of catecholamine synthesis alpha-methyl-para-tyrosine. Catecholamines 166-179 angiotensinogen Rattus norvegicus 4-9 3576418-6 1987 Cachectin infusion precipitated significant increases of plasma catecholamines, cortisol and glucagon in a dose response manner. Catecholamines 64-78 tumor necrosis factor Canis lupus familiaris 0-9 3561488-4 1987 Incubation of permeabilized cells with polyclonal immunoaffinity-purified monospecific anti-alpha-fodrin antibody or its Fab fragments did not modify basal release but did specifically inhibit Ca2+-induced catecholamine release by exocytosis. Catecholamines 206-219 spectrin alpha, non-erythrocytic 1 Homo sapiens 92-104 3676447-4 1987 The possibility that actin and myosin are involved in catecholamine secretion was investigated by determining whether increased phosphorylation in the presence of [gamma-32P]ATP of myosin light chain by myosin light chain kinase enhances secretion from digitonin-treated chromaffin cells. Catecholamines 54-67 myosin heavy chain 14 Homo sapiens 31-37 3676447-4 1987 The possibility that actin and myosin are involved in catecholamine secretion was investigated by determining whether increased phosphorylation in the presence of [gamma-32P]ATP of myosin light chain by myosin light chain kinase enhances secretion from digitonin-treated chromaffin cells. Catecholamines 54-67 myosin heavy chain 14 Homo sapiens 181-187 3676447-4 1987 The possibility that actin and myosin are involved in catecholamine secretion was investigated by determining whether increased phosphorylation in the presence of [gamma-32P]ATP of myosin light chain by myosin light chain kinase enhances secretion from digitonin-treated chromaffin cells. Catecholamines 54-67 myosin heavy chain 14 Homo sapiens 181-187 3299141-5 1987 In consecutive sections, the small glutamate decarboxylase-immunoreactive cell clusters also showed immunoreactivity to tyrosine hydroxylase, suggesting that these cells contain the enzymes for both GABA and catecholamine synthesis. Catecholamines 208-221 glutamate-ammonia ligase Rattus norvegicus 35-58 2882428-2 1987 Tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis. Catecholamines 64-77 tyrosine hydroxylase Homo sapiens 0-20 2882428-2 1987 Tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis. Catecholamines 64-77 tyrosine hydroxylase Homo sapiens 22-24 3595711-1 1987 The present study utilized a time course of CSF catecholamine concentrations during peripheral digoxin administration in vivo to provide a clarification of central catecholaminergic mechanisms involved in digitalis cardiotoxicity. Catecholamines 48-61 colony stimulating factor 2 Canis lupus familiaris 44-47 3607522-3 1987 Catecholamines also bound to the mu opiate receptor agonist morphiceptin (Tyr-Pro-Phe-Pro-NH2). Catecholamines 0-14 opioid receptor mu 1 Homo sapiens 33-51 3036756-1 1987 To test the hypothesis that the high levels of endogenous catecholamines associated with strenuous exercise produce functional desensitization of cardiac beta-adrenergic receptors, we measured the bolus chronotropic dose of isoproterenol necessary to produce a 25-beats/min increase in heart rate (CD25) in the resting state and after the return of heart rate to resting levels after 60 min of treadmill running in 13 normal dogs. Catecholamines 58-72 interleukin 2 receptor subunit alpha Canis lupus familiaris 298-302 3585225-2 1987 To examine the possibility of local catecholaminergic control of prolactin secretion from ectopic pituitaries, pituitary grafted and sham-operated female rats were submitted to several pharmacological treatments modifying catecholamine synthesis. Catecholamines 36-49 prolactin Rattus norvegicus 65-74 3110796-8 1987 These results indicate that changes in the metabolic pathways of splenic catecholamines occur at the peak of the clinical symptoms of EAE; the increase in DOPA and the decrease in DA concentrations suggest that the activity of DOPA-decarboxylase or its co-factor is altered. Catecholamines 73-87 dopa decarboxylase Rattus norvegicus 227-245 3566753-0 1987 Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells. Catecholamines 50-63 myosin light chain kinase Rattus norvegicus 11-36 3566753-3 1987 Myosin light chain kinase may play a stimulatory role in the release reaction of catecholamines from the rat pheochromocytoma cells. Catecholamines 81-95 myosin light chain kinase Rattus norvegicus 0-25 3561696-0 1987 Effect of elevated prolactin levels on the synthesis and release of catecholamines from the adrenal medulla in female rats. Catecholamines 68-82 prolactin Rattus norvegicus 19-28 3494620-1 1987 Depletion of catecholamines by pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-para-tyrosine attenuated the ability of the selective D-2 dopamine receptor agonist quinpirole to inhibit rat nucleus accumbens neurons when applied directly by microiontophoresis. Catecholamines 13-27 dopamine receptor D2 Rattus norvegicus 151-172 2822310-11 1987 Increased pressor sensitivity to catecholamines during ACTH administration in man is not sodium-dependent. Catecholamines 33-47 proopiomelanocortin Homo sapiens 55-59 3817298-1 1987 Two types of monoamine oxidase activity (MAO-A and MAO-B) help regulate the levels of biogenic amines such as catecholamines and serotonin. Catecholamines 110-124 monoamine oxidase A Rattus norvegicus 41-46 3817298-1 1987 Two types of monoamine oxidase activity (MAO-A and MAO-B) help regulate the levels of biogenic amines such as catecholamines and serotonin. Catecholamines 110-124 monoamine oxidase B Rattus norvegicus 51-56 3817298-2 1987 Although MAO-A has greater activity toward most catecholamines than MAO-B, no direct experiments have determined the types and levels of MAO activity that are normally expressed in noradrenergic neurons. Catecholamines 48-62 monoamine oxidase A Rattus norvegicus 9-14 3817298-2 1987 Although MAO-A has greater activity toward most catecholamines than MAO-B, no direct experiments have determined the types and levels of MAO activity that are normally expressed in noradrenergic neurons. Catecholamines 48-62 monoamine oxidase A Rattus norvegicus 9-12 3817298-9 1987 The corresponding decreases in both MAO-A specific activity and catecholamine synthesis as neurons become cholinergic in vitro suggest that the expression of the noradrenergic phenotype involves the coordinate regulation of degradative as well as synthetic enzymes involved in catecholamine metabolism. Catecholamines 277-290 monoamine oxidase A Rattus norvegicus 36-41 2884573-1 1987 In the present study we have investigated the effects of oestrogens, catechol oestrogens, and catecholamines on tyrosine hydroxylase (TH) activity derived from rabbit mesenteric artery and vas deferens. Catecholamines 94-108 LOC100008895 Oryctolagus cuniculus 112-132 2884573-1 1987 In the present study we have investigated the effects of oestrogens, catechol oestrogens, and catecholamines on tyrosine hydroxylase (TH) activity derived from rabbit mesenteric artery and vas deferens. Catecholamines 94-108 LOC100008895 Oryctolagus cuniculus 134-136 3561696-1 1987 Recent evidence suggests that increased plasma prolactin (PRL) levels could be modifying the synthesis and release of catecholamines (CA) from the adrenal medulla. Catecholamines 118-132 prolactin Rattus norvegicus 47-56 3561696-1 1987 Recent evidence suggests that increased plasma prolactin (PRL) levels could be modifying the synthesis and release of catecholamines (CA) from the adrenal medulla. Catecholamines 118-132 prolactin Rattus norvegicus 58-61 3508096-2 1987 Conjugated catecholamines (sulfate form) are hydrolyzed by a sulfatase-mediated reaction to the corresponding free amines. Catecholamines 11-25 arylsulfatase family member H Homo sapiens 61-70 3589002-2 1987 administration of increasing doses of neuropeptide Y (NPY; 7.5-750 pmol/rat) the catecholamine levels and turnover were quantitatively measured in discrete hypothalamic regions by means of histofluorometry. Catecholamines 81-94 neuropeptide Y Rattus norvegicus 38-52 2439067-2 1987 Two antibodies which reacted with receptor alpha-subunit and completely inhibited 125I-insulin binding mimicked the actions of insulin to stimulate lipogenesis from [14C]glucose and to inhibit catecholamine-induced lipolysis. Catecholamines 193-206 insulin Homo sapiens 87-94 2439067-2 1987 Two antibodies which reacted with receptor alpha-subunit and completely inhibited 125I-insulin binding mimicked the actions of insulin to stimulate lipogenesis from [14C]glucose and to inhibit catecholamine-induced lipolysis. Catecholamines 193-206 insulin Homo sapiens 127-134 3828811-4 1987 The results suggest a distinct role of angiotensin II in the modulation of catecholamine release in the SH rat. Catecholamines 75-88 angiotensinogen Rattus norvegicus 39-53 3028183-8 1987 Taken together these data suggest that the renin-angiotensin system plays a more important role in the maintenance of cardiovascular homeostasis in newborn lambs than it does in adult sheep, and catecholamine and vasopressin responses to volume loss can occur in the presence of blockade of the renin-angiotensin system. Catecholamines 195-208 renin Ovis aries 43-48 2887082-2 1987 An immunohistochemical study on tyrosine hydroxylase (TH), a rate-limiting enzyme in the catecholamine synthesizing pathway, was made on three craniocervical region paragangliomas, two of which showed metastases to the cervical lymph nodes. Catecholamines 89-102 tyrosine hydroxylase Homo sapiens 32-52 2887082-2 1987 An immunohistochemical study on tyrosine hydroxylase (TH), a rate-limiting enzyme in the catecholamine synthesizing pathway, was made on three craniocervical region paragangliomas, two of which showed metastases to the cervical lymph nodes. Catecholamines 89-102 tyrosine hydroxylase Homo sapiens 54-56 2887082-7 1987 Application of the TH immunohistochemistry to further cases appears important for the better understanding of this neoplasm, a catecholamine-producing tumor. Catecholamines 127-140 tyrosine hydroxylase Homo sapiens 19-21 3547411-1 1987 Recent evidence suggests that catecholamines inhibit insulin release by stimulating alpha 2-adrenoreceptors in beta-cells of the pancreatic islets. Catecholamines 30-44 insulin Canis lupus familiaris 53-60 3032719-0 1987 Catecholamines and tumour promoting phorbolesters inhibit insulin receptor kinase and induce insulin resistance in isolated human adipocytes. Catecholamines 0-14 insulin Homo sapiens 58-65 3032719-0 1987 Catecholamines and tumour promoting phorbolesters inhibit insulin receptor kinase and induce insulin resistance in isolated human adipocytes. Catecholamines 0-14 insulin Homo sapiens 93-100 3032719-7 1987 We conclude from the data that catecholamine and phorbolester treatment of human adipocytes modulates the kinase activity of the insulin receptor by increasing its Michaelis constant for adenosine-triphosphate, and propose that this modulation of receptor kinase is a mechanism that can contribute to the pathogenesis of insulin resistance in human fat cells. Catecholamines 31-44 insulin Homo sapiens 129-136 3032719-7 1987 We conclude from the data that catecholamine and phorbolester treatment of human adipocytes modulates the kinase activity of the insulin receptor by increasing its Michaelis constant for adenosine-triphosphate, and propose that this modulation of receptor kinase is a mechanism that can contribute to the pathogenesis of insulin resistance in human fat cells. Catecholamines 31-44 insulin Homo sapiens 321-328 2883207-9 1987 The analysis of immunoreactivity to the catecholamine-synthesizing enzymes showed that there was a cell population with intense reactivity to both tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 40-53 tyrosine hydroxylase Rattus norvegicus 147-167 2883207-9 1987 The analysis of immunoreactivity to the catecholamine-synthesizing enzymes showed that there was a cell population with intense reactivity to both tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 40-53 tyrosine hydroxylase Rattus norvegicus 169-171 2883207-9 1987 The analysis of immunoreactivity to the catecholamine-synthesizing enzymes showed that there was a cell population with intense reactivity to both tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 177-202 2883207-9 1987 The analysis of immunoreactivity to the catecholamine-synthesizing enzymes showed that there was a cell population with intense reactivity to both tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 204-207 2829507-2 1987 a) In the hypothalamus, NPY immunoreactive neurons are non catecholamine containing neurons whereas in the medulla oblongata NPY is present in the majority of the catecholamine neurons. Catecholamines 59-72 neuropeptide Y Homo sapiens 24-27 2829507-9 1987 e) Central NPY administration leads to alterations in serum levels of corticosterone, aldosterone, angiotensin II, vasopressin, PRL, LH, GH and TSH which are parallel to changes in discrete hypothalamic catecholamine neuronal systems. Catecholamines 203-216 neuropeptide Y Homo sapiens 11-14 3035984-10 1987 Chromogranin A levels are essentially unaffected by any of the agents which increase enkephalin and VIP levels, although it is secreted in parallel with enkephalins and catecholamines from chromaffin cells in response to secretagogues. Catecholamines 169-183 chromogranin A Homo sapiens 0-14 3035894-6 1987 Thus, in addition to its recognized modulatory effects in the peripheral adrenergic system, angiotensin II may be involved in the central control of catecholamine release and action. Catecholamines 149-162 angiotensinogen Homo sapiens 92-106 3035894-3 1987 In the adrenal gland, angiotensin II receptors are abundant in the zona glomerulosa but are also present in the medulla, where the occurrence of CRF receptors and actions on catecholamine release reveals an additional site at which the two peptides exert related actions, in this case in the peripheral neuroendocrine system. Catecholamines 174-187 angiotensinogen Homo sapiens 22-36 3812732-0 1987 Peripheral and brain tissue catecholamine content in intact and anti-NGF-treated fetal sheep. Catecholamines 28-41 beta-nerve growth factor Ovis aries 69-72 3812732-7 1987 Also the results suggest that NGF may play a role in the development of catecholamine-containing neurons within the central nervous system. Catecholamines 72-85 beta-nerve growth factor Ovis aries 30-33 3551809-6 1987 A third group of functions is the synaptic, neurotransmitter interactions of Ang II with catecholamines, serotonin, prostaglandins, and other peptides, not all of which could be reviewed here due to space limitations. Catecholamines 89-103 angiogenin Homo sapiens 77-80 3304733-0 1987 Vasopressin in end-stage renal disease: relationship to salt, catecholamines and renin activity. Catecholamines 62-76 arginine vasopressin Homo sapiens 0-11 3038326-1 1987 Recent experimental studies showed that inhibition of angiotensin II synthesis may reduce sympathetic activity as evaluated by plasma catecholamine assay, sharing in the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors. Catecholamines 134-147 angiotensinogen Homo sapiens 54-68 3427772-11 1987 However, plasma catecholamine levels were significantly lower (30-70%) in endotoxemic rats treated with the PAF antagonist. Catecholamines 16-29 PCNA clamp associated factor Rattus norvegicus 108-111 3677334-10 1987 These results suggest that adrenal cortical glucocorticoids, in addition to adrenal medullary catecholamines, participate in the recovery from the cardiovascular alterations following PAF administration. Catecholamines 94-108 PCNA clamp associated factor Rattus norvegicus 184-187 3549165-0 1987 Peripherally delivered renin supports reflex adrenal catecholamine secretion in anephric dogs. Catecholamines 53-66 renin Canis lupus familiaris 23-28 3542342-2 1987 However, hypomagnesaemia has been reported in patients in clinical situations where circulating catecholamines are raised including myocardial infarction, cardiac surgery and insulin-induced hypoglycaemia stress tests. Catecholamines 96-110 insulin Homo sapiens 175-182 2891559-1 1987 Using specific antisera against the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), in combination with the peroxidase-antiperoxidase method and/or the avidin-biotin complex method, we have found a new group of TH immunoreactive (TH-I) neurons in the rat cerebral cortex. Catecholamines 36-49 tyrosine hydroxylase Rattus norvegicus 71-91 2455133-6 1987 The calcium antagonist verapamil and the beta-blocker propranolol may increase LDL receptor activity either per se or by its antagonizing effect on the catecholamine action. Catecholamines 152-165 low density lipoprotein receptor Homo sapiens 79-91 3691412-5 1987 The results demonstrate that (1) reactivity to angiotensin II, serotonin, epinephrine, and acute hypoxia is decreased during pregnancy, while the response to norepinephrine remain unchanged, (2) drug sensitivity is unchanged with serotonin and the catecholamines, increased with histamine, and decreased with angiotensin II, and (3) the responses to acute hypoxia and histamine have significant gender-related differences in reactivity independent of the changes observed during pregnancy. Catecholamines 248-262 angiotensinogen Homo sapiens 47-61 2455133-5 1987 Catecholamines suppress the LDL receptor activity, thus leading to an increase in plasma cholesterol concentration. Catecholamines 0-14 low density lipoprotein receptor Homo sapiens 28-40 3316041-4 1987 Catecholamine excretion in urine (adrenaline + noradrenaline) on average was 252.3 +/- 77.9 ng min-1 during car racing and 121.9 +/- 37.3 ng min-1 during exhaustive ergometry (n = 10). Catecholamines 0-13 CD59 molecule (CD59 blood group) Homo sapiens 95-100 2441195-7 1987 Angiotensin II mediated vasoconstriction perhaps enhanced by catecholamines could have deleterious effects on myocardial function and perfusion, and indicates the potential for angiotensin-converting enzyme inhibitors in early AMI. Catecholamines 61-75 angiotensinogen Homo sapiens 0-14 2455160-0 1987 Relationship of substance P to catecholamines, stress, and hypertension. Catecholamines 31-45 tachykinin precursor 1 Homo sapiens 16-27 2455160-4 1987 Substance P normalizes stress-induced disorders by maintaining homeostasis in the catecholamine system. Catecholamines 82-95 tachykinin precursor 1 Homo sapiens 0-11 2455193-1 1987 The present paper summarizes some recent studies supporting that neuropeptide Y (NPY) is involved as a cotransmitter or modulator with catecholamines (CA) in peripheral, sympathetic, and cardiovascular control, and that many drugs used for the studies or treatment of hypertensive disorders influence NPY mechanisms both at the pre- and postjunctional levels. Catecholamines 135-149 neuropeptide Y Homo sapiens 65-79 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 179-193 tyrosine 3-monooxygenase Cavia porcellus 73-93 2455193-1 1987 The present paper summarizes some recent studies supporting that neuropeptide Y (NPY) is involved as a cotransmitter or modulator with catecholamines (CA) in peripheral, sympathetic, and cardiovascular control, and that many drugs used for the studies or treatment of hypertensive disorders influence NPY mechanisms both at the pre- and postjunctional levels. Catecholamines 135-149 neuropeptide Y Homo sapiens 81-84 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 179-193 tyrosine 3-monooxygenase Cavia porcellus 95-97 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 179-193 dopamine beta-hydroxylase Cavia porcellus 103-128 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 179-193 dopamine beta-hydroxylase Cavia porcellus 130-133 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 195-198 tyrosine 3-monooxygenase Cavia porcellus 73-93 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 195-198 tyrosine 3-monooxygenase Cavia porcellus 95-97 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 195-198 dopamine beta-hydroxylase Cavia porcellus 103-128 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Catecholamines 195-198 dopamine beta-hydroxylase Cavia porcellus 130-133 2883324-1 1987 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines in neural tissues and adrenal medulla. Catecholamines 74-88 tyrosine hydroxylase Rattus norvegicus 0-20 2883324-1 1987 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines in neural tissues and adrenal medulla. Catecholamines 74-88 tyrosine hydroxylase Rattus norvegicus 22-24 2830565-4 1987 It has been found that chronic stress causes a selective desensitization of the alpha receptors (alpha-1 subtype) producing a partial reduction of the overall cAMP response to catecholamines. Catecholamines 176-190 adrenoceptor alpha 1D Homo sapiens 97-104 2894459-2 1987 In view of the catecholamine hypothesis of this disorder, the gene encoding tyrosine hydroxylase (TH) the limiting enzyme in catecholamines is a good candidate to investigate. Catecholamines 15-28 tyrosine hydroxylase Homo sapiens 76-96 2894459-2 1987 In view of the catecholamine hypothesis of this disorder, the gene encoding tyrosine hydroxylase (TH) the limiting enzyme in catecholamines is a good candidate to investigate. Catecholamines 125-139 tyrosine hydroxylase Homo sapiens 76-96 2879289-1 1987 Tyrosine hydroxylase [TyrOHase, tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (2-hydroxylating), EC 1.14.16.2] is the rate-limiting enzyme in the synthetic pathway of catecholamines and is expressed by neurons containing dopamine, norepinephrine, and epinephrine. Catecholamines 201-215 tyrosine hydroxylase Homo sapiens 32-56 3805350-0 1986 Diencephalic catecholamine neurons (A-11, A-12, A-13, A-14) show divergent changes in the aged rat. Catecholamines 13-26 selectin L Rattus norvegicus 36-40 3822234-0 1986 Stimulation by vasoactive intestinal polypeptide of muscarinic receptor-mediated catecholamine secretion from isolated guinea pig adrenal medullary cells. Catecholamines 81-94 VIP peptides Cavia porcellus 15-48 3822234-1 1986 The effects of vasoactive intestinal polypeptide (VIP) on catecholamine (CA) secretion by isolated guinea pig adrenal medullary cells were studied. Catecholamines 58-71 VIP peptides Cavia porcellus 50-53 2878337-1 1986 A rapid, simple and sensitive assay has been developed for tyrosine-3-monooxygenase, the enzyme catalyzing the rate-limiting step in catecholamine biosynthesis. Catecholamines 133-146 tyrosine hydroxylase Homo sapiens 59-83 2881593-0 1986 Catecholamine innervation of LH-RH neurons: a developmental study. Catecholamines 0-13 gonadotropin releasing hormone 1 Rattus norvegicus 29-34 2881593-1 1986 Catecholamine innervation of luteinizing hormone-releasing hormone (LH-RH) cell subtypes in rats was investigated over development using double label, light microscopic immunocytochemistry. Catecholamines 0-13 gonadotropin releasing hormone 1 Rattus norvegicus 29-66 2881593-1 1986 Catecholamine innervation of luteinizing hormone-releasing hormone (LH-RH) cell subtypes in rats was investigated over development using double label, light microscopic immunocytochemistry. Catecholamines 0-13 gonadotropin releasing hormone 1 Rattus norvegicus 68-73 2949886-8 1986 The ANP-mediated reduction in arterial pressure was associated with an increase in circulating arginine vasopressin and catecholamines but not in renin. Catecholamines 120-134 natriuretic peptide A Canis lupus familiaris 4-7 2435394-0 1986 Effects of substance P on the long-term regulation of tyrosine hydroxylase activity and catecholamine levels in cultured adrenal chromaffin cells. Catecholamines 88-101 tachykinin precursor 1 Bos taurus 11-22 3494050-9 1986 It is concluded that acute EGF infusion increases heart rate and stimulates catecholamine secretion in fetal sheep. Catecholamines 76-89 EGF Ovis aries 27-30 2946301-12 1986 We conclude that the induction of PNMT by reserpine involves depletion of catecholamines and serotonin, the depletion of serotonin having the more powerful effect. Catecholamines 74-88 phenylethanolamine-N-methyltransferase Rattus norvegicus 34-38 3098930-0 1986 Perturbed pattern of catecholamine-containing neurons in mutant Drosophila deficient in the enzyme dopa decarboxylase. Catecholamines 21-34 Dopa decarboxylase Drosophila melanogaster 99-117 2432203-8 1986 With regard to mesencephalic and medullary catecholamine neurons, GAL-LI coexisted in a large proportion of the noradrenergic locus coeruleus somata (A6 cell group) and in the A4 group dorsolateral to the fourth ventricle, as well as in the caudal parts of the A2 group in the dorsal vagal complex. Catecholamines 43-56 galanin and GMAP prepropeptide Rattus norvegicus 66-69 3538020-3 1986 Two hours of insulin hypoglycemia, which produced intense reflex stimulation of the splanchnic nerves as evidenced by a 55% decrease in the adrenal medulla catecholamine levels, resulted in a 3-fold increase in proenkephalin A mRNA levels in this tissue. Catecholamines 156-169 proenkephalin Rattus norvegicus 211-226 3780966-0 1986 Aliphatic side chain of catecholamine potentiates the stimulatory effect of the catechol part on the synthesis of nerve growth factor. Catecholamines 24-37 nerve growth factor Mus musculus 114-133 3780966-1 1986 Catecholamines are potent in stimulating nerve growth factor (NGF) synthesis in mouse L-M cells. Catecholamines 0-14 nerve growth factor Mus musculus 41-60 3780966-1 1986 Catecholamines are potent in stimulating nerve growth factor (NGF) synthesis in mouse L-M cells. Catecholamines 0-14 nerve growth factor Mus musculus 62-65 3780966-2 1986 The relationship between the structure of catecholamines and their stimulatory effect on NGF synthesis has been studied using various 3,4-dihydroxyphenyl derivatives or their analogues. Catecholamines 42-56 nerve growth factor Mus musculus 89-92 3778497-0 1986 Synergistic actions of Ca2+ and the phorbol ester TPA on K+-induced catecholamine release from bovine adrenal chromaffin cells. Catecholamines 68-81 plasminogen activator, tissue type Bos taurus 50-53 3540039-1 1986 The distribution and morphology of cell bodies containing the catecholamine biosynthetic enzymes dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the ventrolateral medulla (VLM) of the cat were studied immunohistochemically after intracisternal administration of colchicine. Catecholamines 62-75 dopamine beta hydroxylase Mus musculus 97-122 3540039-1 1986 The distribution and morphology of cell bodies containing the catecholamine biosynthetic enzymes dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the ventrolateral medulla (VLM) of the cat were studied immunohistochemically after intracisternal administration of colchicine. Catecholamines 62-75 dopamine beta hydroxylase Mus musculus 124-127 3540039-1 1986 The distribution and morphology of cell bodies containing the catecholamine biosynthetic enzymes dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the ventrolateral medulla (VLM) of the cat were studied immunohistochemically after intracisternal administration of colchicine. Catecholamines 62-75 phenylethanolamine-N-methyltransferase Mus musculus 173-177 2879604-2 1986 For this purpose, the biochemical response of the NA cell bodies of the LC after a lesion of the C2 region was studied by using as markers the in vitro activities of the catecholamine synthesizing enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 170-183 tyrosine hydroxylase Rattus norvegicus 206-226 3778497-1 1986 Enhancement of Ca2+-dependent high K+-evoked catecholamine secretion was observed after pretreatment of cultured bovine adrenal chromaffin cells with the phorbol ester 4B-phorbol 12-myristate 13-acetate (TPA) in the absence of added extracellular Ca2+. Catecholamines 45-58 plasminogen activator, tissue type Bos taurus 204-207 3779414-6 1986 Inhibiting catecholamine synthesis significantly elevated plasma prolactin and reduced the voltammetric current. Catecholamines 11-24 prolactin Rattus norvegicus 65-74 3023395-13 1986 In addition, angiotensin II increased and TPA inhibited catecholamine-stimulated inositol phosphate release. Catecholamines 56-69 angiotensinogen Homo sapiens 13-27 2879374-0 1986 Correlation between tyrosine hydroxylase immunoreactive cells in tumors and urinary catecholamine output in neuroblastoma patients. Catecholamines 84-97 tyrosine hydroxylase Homo sapiens 20-40 2879374-2 1986 Although no correlations could be found between the immunoreactive pattern and the site of origin or the staging of the tumor, a positive relationship between the urinary catecholamine output and the density of TH-immunoreactive cells could be established. Catecholamines 171-184 tyrosine hydroxylase Homo sapiens 211-213 3465676-1 1986 Catechol-O-methyltransferase (COMT) plays an important role in the inactivation of catecholamines. Catecholamines 83-97 catechol-O-methyltransferase Homo sapiens 0-28 3465676-1 1986 Catechol-O-methyltransferase (COMT) plays an important role in the inactivation of catecholamines. Catecholamines 83-97 catechol-O-methyltransferase Homo sapiens 30-34 2431356-0 1986 The effect of neuropeptide Y on striatal catecholamines. Catecholamines 41-55 neuropeptide Y Rattus norvegicus 14-28 2431012-1 1986 These studies document species differences in the distribution of the peptide substance P and the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) within a central nervous system region of a number of mammalian species including the mouse, rat, guinea pig, rabbit, cat, and two species of hamster (Chinese and Syrian). Catecholamines 98-111 tyrosine 3-monooxygenase Mesocricetus auratus 132-152 2878821-7 1986 The absence of TH enzyme in the PNMT-positive cells raises the question of the enzymatic activity of PNMT, which appears to be different from the classical pathway of catecholamine biosynthesis in the retina. Catecholamines 167-180 phenylethanolamine-N-methyltransferase Rattus norvegicus 101-105 3467755-1 1986 Both arylsulfatases (EC 3.1.6.1, ARS) A and B purified from human kidney displayed Michaelis-Menten kinetics towards catecholamines sulfates as substrates with Km values in the range of 4-25 mM. Catecholamines 117-131 RIEG2 Homo sapiens 33-36 3536002-6 1986 The addition of cholecystokinin (CCK) in a concentration of 2.0-6.0 ng/microliter to the CSF perfused in PVN or VMN of the satiated rat enhanced the efflux of NE; however, in the fasted animal CCK often suppressed the catecholamine"s release. Catecholamines 218-231 cholecystokinin Rattus norvegicus 16-31 3536002-6 1986 The addition of cholecystokinin (CCK) in a concentration of 2.0-6.0 ng/microliter to the CSF perfused in PVN or VMN of the satiated rat enhanced the efflux of NE; however, in the fasted animal CCK often suppressed the catecholamine"s release. Catecholamines 218-231 cholecystokinin Rattus norvegicus 33-36 3018160-1 1986 Previous evidence has suggested that brain catecholamine levels are important in the regulation of central angiotensin II receptors. Catecholamines 43-56 angiotensinogen Rattus norvegicus 107-121 2430004-11 1986 Because oxygen metabolites generated by the FMN are mediators of inflammation and hypersensitivity, direct inhibition of PMN activation as well as potentiation of catecholamine activity may be important therapeutic effects of theophylline and enprofylline. Catecholamines 163-176 formin 1 Homo sapiens 44-47 2875946-1 1986 Elevation of brain catecholamine levels by systemic administration of L-dopa in dogs pretreated with the dopa decarboxylase inhibitor carbidopa inhibits the secretion of vasopressin and adrenocorticotropic hormone (ACTH) and decreases arterial blood pressure. Catecholamines 19-32 dopa decarboxylase Canis lupus familiaris 105-123 2875946-1 1986 Elevation of brain catecholamine levels by systemic administration of L-dopa in dogs pretreated with the dopa decarboxylase inhibitor carbidopa inhibits the secretion of vasopressin and adrenocorticotropic hormone (ACTH) and decreases arterial blood pressure. Catecholamines 19-32 proopiomelanocortin Canis lupus familiaris 186-213 2875946-1 1986 Elevation of brain catecholamine levels by systemic administration of L-dopa in dogs pretreated with the dopa decarboxylase inhibitor carbidopa inhibits the secretion of vasopressin and adrenocorticotropic hormone (ACTH) and decreases arterial blood pressure. Catecholamines 19-32 proopiomelanocortin Canis lupus familiaris 215-219 3021571-1 1986 The region surrounding the dopa decarboxylase gene of Drosophila contains a cluster of functionally related genes, many of which affect cuticle development and/or catecholamine metabolism. Catecholamines 163-176 Dopa decarboxylase Drosophila melanogaster 27-45 3021572-1 1986 The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. Catecholamines 205-218 Dopa decarboxylase Drosophila melanogaster 27-45 3021572-1 1986 The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. Catecholamines 205-218 Dopa decarboxylase Drosophila melanogaster 52-55 3018160-3 1986 Both catecholamines elicit significant decreases in [125I]angiotensin II-specific binding to neuronal cultures prepared from normotensive rats, effects that are dose dependent and that are maximal within 4-8 h of preincubation. Catecholamines 5-19 angiotensinogen Rattus norvegicus 58-72 2876427-1 1986 Tyrosine hydroxylase [TyrOHase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2], an essential enzyme in the synthesis of catecholamines, is expressed normally by neurons in the brainstem but not by those in mature neocortex. Catecholamines 160-174 tyrosine hydroxylase Homo sapiens 0-20 3023761-0 1986 Catecholamine-induced suppression of interleukin-1 production. Catecholamines 0-13 interleukin 1 complex Mus musculus 37-50 3023761-6 1986 Moreover, when intracellular and extracellular levels of IL-1 were quantitated, the studies demonstrated a catecholamine-mediated block in IL-1 synthesis without effect on its release. Catecholamines 107-120 interleukin 1 complex Mus musculus 57-61 3023761-6 1986 Moreover, when intracellular and extracellular levels of IL-1 were quantitated, the studies demonstrated a catecholamine-mediated block in IL-1 synthesis without effect on its release. Catecholamines 107-120 interleukin 1 complex Mus musculus 139-143 3023761-8 1986 This, coupled with the capacity of norepinephrine and epinephrine to enhance intracellular cAMP levels in macrophages, strongly suggested that the catecholamine-induced suppression of IL-1 production may be mediated by elevated intracellular cAMP levels. Catecholamines 147-160 interleukin 1 complex Mus musculus 184-188 2876427-1 1986 Tyrosine hydroxylase [TyrOHase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2], an essential enzyme in the synthesis of catecholamines, is expressed normally by neurons in the brainstem but not by those in mature neocortex. Catecholamines 160-174 tyrosine hydroxylase Homo sapiens 22-30 3024878-0 1986 The effect of peripheral catecholamine concentrations on the pituitary-adrenal response to corticotrophin releasing factor in man. Catecholamines 25-38 corticotropin releasing hormone Homo sapiens 91-122 3538692-4 1986 S100 protein-positive elements also correlated with the histological differentiation, and were distributed mostly in the area where the catecholamine-containing neurofibres were located. Catecholamines 136-149 S100 calcium binding protein A1 Homo sapiens 0-4 3018587-1 1986 Chromogranin A is contained in storage vesicles of chromaffin cells of the adrenal medulla and released with catecholamines when the splanchnic nerve is stimulated. Catecholamines 109-123 chromogranin A Bos taurus 0-14 2429074-9 1986 was prevented by pretreatment with propranolol, desmethylimipramine, and the dopa-decarboxylase inhibitor R04-4602, but not by pretreatment with pentolinium, guanethidine, the dopamine-beta-hydroxylase inhibitor FLA-63, or by adrenalectomy or depletion of endogenous catecholamines. Catecholamines 267-281 dopa decarboxylase Rattus norvegicus 77-95 2875140-1 1986 We sought to determine the ultrastructural localization and the extrinsic sources of the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), in the lateral parabrachial region (PBR) of adult male rats. Catecholamines 89-102 tyrosine hydroxylase Rattus norvegicus 124-144 2875140-1 1986 We sought to determine the ultrastructural localization and the extrinsic sources of the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), in the lateral parabrachial region (PBR) of adult male rats. Catecholamines 89-102 tyrosine hydroxylase Rattus norvegicus 146-148 3538108-4 1986 After 3 weeks of administration of therapeutic doses of lithium carbonate, healthy volunteers showed a differential response of catecholamines to insulin stimulation. Catecholamines 128-142 insulin Homo sapiens 146-153 3760482-3 1986 The present study was undertaken to investigate the direct effects of the hormones prolactin, angiotensin II and cortisol on catecholamine release from fetal adrenal medulla, and to determine whether the effect of the hormones change during development into adulthood. Catecholamines 125-138 prolactin Ovis aries 83-92 3763044-5 1986 Release of catecholamines by Ba was accompanied by the release of dopamine beta-hydroxylase, both in the permeabilized and control cells, showing that Ba causes an exocytotic release of catecholamines. Catecholamines 11-25 dopamine beta-hydroxylase Bos taurus 66-91 3763044-5 1986 Release of catecholamines by Ba was accompanied by the release of dopamine beta-hydroxylase, both in the permeabilized and control cells, showing that Ba causes an exocytotic release of catecholamines. Catecholamines 186-200 dopamine beta-hydroxylase Bos taurus 66-91 3092183-1 1986 A transcript has been localized proximal to the dopa decarboxylase (Ddc) gene within a cluster of genes involved in cuticle formation and catecholamine metabolism in Drosophila. Catecholamines 138-151 Dopa decarboxylase Drosophila melanogaster 48-66 3092183-1 1986 A transcript has been localized proximal to the dopa decarboxylase (Ddc) gene within a cluster of genes involved in cuticle formation and catecholamine metabolism in Drosophila. Catecholamines 138-151 Dopa decarboxylase Drosophila melanogaster 68-71 2878540-7 1986 Modern treatment strategies (combined L-dopa therapy, dopaminergic agonists, MAO-B inhibitors, amantadine) are able to substitute the deficiency especially of the catecholamines. Catecholamines 163-177 monoamine oxidase B Homo sapiens 77-82 2874868-2 1986 Exposure to the depolarizing agents veratridine or elevated K+ significantly increased the catalytic activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 168-181 tyrosine hydroxylase Mus musculus 113-133 2874868-2 1986 Exposure to the depolarizing agents veratridine or elevated K+ significantly increased the catalytic activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 168-181 tyrosine hydroxylase Mus musculus 135-137 3760482-8 1986 In newborn cells, only the highest concentration of 200 micrograms/ml ovine prolactin stimulated total catecholamine release at 6 h and 12 h, with significant increases of the three catecholamines at 12 h. In maternal cells, stimulation of catecholamine release was observed also with the highest concentration of prolactin tested (200 micrograms/ml) and after 12 h of incubation, when only the release of epinephrine was significantly enhanced by 324%. Catecholamines 182-196 prolactin Ovis aries 76-85 3760482-8 1986 In newborn cells, only the highest concentration of 200 micrograms/ml ovine prolactin stimulated total catecholamine release at 6 h and 12 h, with significant increases of the three catecholamines at 12 h. In maternal cells, stimulation of catecholamine release was observed also with the highest concentration of prolactin tested (200 micrograms/ml) and after 12 h of incubation, when only the release of epinephrine was significantly enhanced by 324%. Catecholamines 182-195 prolactin Ovis aries 76-85 3760482-8 1986 In newborn cells, only the highest concentration of 200 micrograms/ml ovine prolactin stimulated total catecholamine release at 6 h and 12 h, with significant increases of the three catecholamines at 12 h. In maternal cells, stimulation of catecholamine release was observed also with the highest concentration of prolactin tested (200 micrograms/ml) and after 12 h of incubation, when only the release of epinephrine was significantly enhanced by 324%. Catecholamines 103-116 prolactin Ovis aries 76-85 3729693-4 1986 When high levels of catecholamines are found, without further evidence of a pheochromocytoma, treatment with a beta blocker is appropriate. Catecholamines 20-34 amyloid beta precursor protein Homo sapiens 109-115 2874553-4 1986 Antibodies specific for tyrosine hydroxylase [EC 1.14.16.2, tyrosine 3-monooxygenase; L-tyrosine, tetrahydrobiopterine: oxygen oxidoreductase (3-hydroxylating)], the first enzyme in the catecholamine pathway, possess a striking affinity for the PNMTase protein synthesized in vitro. Catecholamines 186-199 tyrosine hydroxylase Bos taurus 24-44 2874553-5 1986 Comparison of the deduced amino acid sequence of bovine PNMTase to rat tyrosine hydroxylase reveals that PNMTase shares significant homology with tyrosine hydroxylase and supports previous protein and immunological data suggesting that the catecholamine biosynthetic enzymes are structurally related. Catecholamines 240-253 phenylethanolamine N-methyltransferase Bos taurus 56-63 2874553-5 1986 Comparison of the deduced amino acid sequence of bovine PNMTase to rat tyrosine hydroxylase reveals that PNMTase shares significant homology with tyrosine hydroxylase and supports previous protein and immunological data suggesting that the catecholamine biosynthetic enzymes are structurally related. Catecholamines 240-253 tyrosine hydroxylase Rattus norvegicus 71-91 2874553-5 1986 Comparison of the deduced amino acid sequence of bovine PNMTase to rat tyrosine hydroxylase reveals that PNMTase shares significant homology with tyrosine hydroxylase and supports previous protein and immunological data suggesting that the catecholamine biosynthetic enzymes are structurally related. Catecholamines 240-253 phenylethanolamine-N-methyltransferase Rattus norvegicus 105-112 2874553-5 1986 Comparison of the deduced amino acid sequence of bovine PNMTase to rat tyrosine hydroxylase reveals that PNMTase shares significant homology with tyrosine hydroxylase and supports previous protein and immunological data suggesting that the catecholamine biosynthetic enzymes are structurally related. Catecholamines 240-253 tyrosine hydroxylase Rattus norvegicus 146-166 3017797-0 1986 Studies on the insulin-antagonistic effect of catecholamines in normal man. Catecholamines 46-60 insulin Homo sapiens 15-22 2875048-2 1986 Biochemical assays examined the neurotransmitter synthesizing enzymes tyrosine hydroxylase (TOH) for catecholamines and choline acetyltransferase (CAT) for acetylcholine. Catecholamines 101-115 tyrosine hydroxylase Homo sapiens 92-95 3518811-10 1986 When cells were incubated with both adenosine deaminase and isoproterenol, the inhibition of the insulin response was greater at all concentrations of catecholamine and was almost completely blocked at isoproterenol concentrations of 10 nM or less. Catecholamines 151-164 adenosine deaminase Rattus norvegicus 36-55 3711722-9 1986 Myocardial catecholamines were also determined in 14 subjects; a weak correlation (r = 0.57, P less than 0.05) between the tissue concentrations of VIP and norepinephrine was noted. Catecholamines 11-25 vasoactive intestinal peptide Homo sapiens 148-151 2873046-1 1986 In brain regions containing noradrenergic (NA) cell bodies or terminals, DSP-4 induces changes in the activity of catecholamine-synthesizing enzymes which suggest that central NA neurons are lesioned by this neurotoxin. Catecholamines 114-127 dual specificity phosphatase 26 Homo sapiens 73-78 2940358-3 1986 administration of synthetic human beta-endorphin to increase plasma catecholamine concentrations, presumably by acting at opioid receptors in the brain to stimulate the central sympathetic outflow to adrenal medulla and peripheral sympathetic nerve terminals. Catecholamines 68-81 proopiomelanocortin Homo sapiens 34-48 2940358-4 1986 This beta-endorphin-induced increase in plasma catecholamine concentration is dose-dependent, inhibited by naloxone and blocked by bilateral adrenal gland denervation or ganglionic blockade with chlorisondamine. Catecholamines 47-60 proopiomelanocortin Homo sapiens 5-19 2940358-6 1986 In this study we examined the possibility of central noradrenergic regulation of beta-endorphin-induced catecholamine secretion. Catecholamines 104-117 proopiomelanocortin Homo sapiens 81-95 2940358-15 1986 norepinephrine on beta-endorphin-induced catecholamine secretion. Catecholamines 41-54 proopiomelanocortin Homo sapiens 18-32 3087578-1 1986 6-Hydroxydopamine-induced catecholamine denervations in the organum vasculosum of the lamina terminalis and the median preoptic nucleus attenuate drinking responses to systemic angiotensin II (ANG II) injections. Catecholamines 26-39 angiotensinogen Homo sapiens 177-191 3087578-1 1986 6-Hydroxydopamine-induced catecholamine denervations in the organum vasculosum of the lamina terminalis and the median preoptic nucleus attenuate drinking responses to systemic angiotensin II (ANG II) injections. Catecholamines 26-39 angiotensinogen Homo sapiens 193-199 3087578-2 1986 Transplanting catecholamines in these nuclei using fetal noradrenergic (NE) cell suspension restores ANG II-elicited thirst. Catecholamines 14-28 angiotensinogen Homo sapiens 101-107 3758430-3 1986 The elute was then desalinated and deproteinized by the ethanol-treated precipitation procedure and dried in a vacuum oven at 25 degrees C. A fraction of catecholamines was assayed with the modified procedures of the COMT-mediated radio-enzymatic method. Catecholamines 154-168 catechol-O-methyltransferase Homo sapiens 217-221 3711090-9 1986 These data indicate that, under a wide variety of conditions, only one catecholamine biosynthetic enzyme activity, dopamine beta-monooxygenase, is specifically stimulated by ascorbic acid alone in cultured chromaffin cells. Catecholamines 71-84 dopamine beta-hydroxylase Bos taurus 115-142 2872232-10 1986 When insulin was increased by 752 +/- 115 microU/ml, with no change in glucose uptake, energy expenditure rose by 0.05 +/- 0.02 kcal/min, which correlated with the increase in plasma catecholamines. Catecholamines 183-197 insulin Homo sapiens 5-12 2940358-17 1986 norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment. Catecholamines 71-84 proopiomelanocortin Homo sapiens 48-62 3702603-4 1986 In contrast, the S-2 receptor specific binding of (3H)-spiperone in the cerebral cortex decreased in a dose dependent fashion, a direction of change opposite to that usually seen in catecholamine pathways chronically exposed to antagonists. Catecholamines 182-195 src homology 3 binding domain protein 1 Mus musculus 17-20 3085873-4 1986 These results suggest that GRP, NT and DN 1417 act at the hypothalamic catecholamine nerve terminals and stimulate the release of DA and NE in the rat. Catecholamines 71-84 gastrin releasing peptide Rattus norvegicus 27-30 3700383-0 1986 Catecholamines induce an increase in nerve growth factor content in the medium of mouse L-M cells. Catecholamines 0-14 nerve growth factor Mus musculus 37-56 2871469-9 1986 Catecholamine had different effects on TRH levels in RMN and the controls; this might be due to the excess accumulation of noradrenaline in the RMN brain. Catecholamines 0-13 thyrotropin releasing hormone Mus musculus 39-42 3698518-1 1986 Using high-performance liquid chromatography with electrochemical detection, we have studied the release of endogenous catecholamines from washed platelets induced to aggregate by ADP and thrombin. Catecholamines 119-133 coagulation factor II, thrombin Homo sapiens 188-196 3706534-5 1986 ANG II may work in cooperation with catecholamine, but AVP appears to play little role. Catecholamines 36-49 angiotensinogen Rattus norvegicus 0-6 3698518-6 1986 A correlation was observed between catecholamine release and the concentration of thrombin present in incubations. Catecholamines 35-48 coagulation factor II, thrombin Homo sapiens 82-90 3523213-1 1986 A 2 1/2 year old dystrophic girl with polyuria and polydipsia was found to have an arterial hypertension, increased catecholamines in serum and urine, and a suprarenal tumour was diagnosed by ultrasonic scan. Catecholamines 116-130 immunoglobulin kappa variable 2-26 (pseudogene) Homo sapiens 0-7 3007986-1 1986 Chromogranin A, the protein that is co-stored and co-released with catecholamines from the adrenal medulla, has recently been identified in a variety of human endocrine tissues, both normal and neoplastic. Catecholamines 67-81 chromogranin A Homo sapiens 0-14 2943770-0 1986 Correlation between plasma cortisol and CSF catecholamines in endogenous depressed dexamethasone nonsuppressors. Catecholamines 44-58 colony stimulating factor 2 Homo sapiens 40-43 3010132-4 1986 The pharmacologically distinguishable subtypes of the beta-adrenergic receptor, beta 1 and beta 2 receptors, stimulate adenylate cyclase on binding specific catecholamines. Catecholamines 157-171 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 91-97 3011767-8 1986 Although the physiological role of RSP-V has not yet been clarified, this enzyme inactivated dopa decarboxylase alone among catecholamine-synthesizing enzymes. Catecholamines 124-137 dopa decarboxylase Rattus norvegicus 93-111 3534807-0 1986 Fetal adrenal VIP: distribution and effect on medullary catecholamine secretion. Catecholamines 56-69 vasoactive intestinal peptide Homo sapiens 14-17 3534807-1 1986 Vasoactive intestinal peptide (VIP) was found in the adrenal gland of ovine fetuses at 130-135 days gestation and was shown to stimulate catecholamine secretion. Catecholamines 137-150 vasoactive intestinal peptide Homo sapiens 0-29 3534807-1 1986 Vasoactive intestinal peptide (VIP) was found in the adrenal gland of ovine fetuses at 130-135 days gestation and was shown to stimulate catecholamine secretion. Catecholamines 137-150 vasoactive intestinal peptide Homo sapiens 31-34 3534807-6 1986 At 6 hours of incubation, VIP stimulated total catecholamine release from fetal adrenomedullary cells in a dose-dependent manner at concentrations ranging from 10(-8) to 10(-4) M. The release of norepinephrine and epinephrine, but not dopamine, was significantly enhanced. Catecholamines 47-60 vasoactive intestinal peptide Homo sapiens 26-29 3534807-7 1986 The presence of VIP in the fetal adrenal cortex and medulla, and the ability of VIP to stimulate catecholamine release from fetal adrenomedullary cells in vitro suggest that VIP may be an important modulator of medullary catecholamine secretion during fetal life. Catecholamines 97-110 vasoactive intestinal peptide Homo sapiens 80-83 3534807-7 1986 The presence of VIP in the fetal adrenal cortex and medulla, and the ability of VIP to stimulate catecholamine release from fetal adrenomedullary cells in vitro suggest that VIP may be an important modulator of medullary catecholamine secretion during fetal life. Catecholamines 97-110 vasoactive intestinal peptide Homo sapiens 80-83 3534807-7 1986 The presence of VIP in the fetal adrenal cortex and medulla, and the ability of VIP to stimulate catecholamine release from fetal adrenomedullary cells in vitro suggest that VIP may be an important modulator of medullary catecholamine secretion during fetal life. Catecholamines 221-234 vasoactive intestinal peptide Homo sapiens 80-83 3534807-7 1986 The presence of VIP in the fetal adrenal cortex and medulla, and the ability of VIP to stimulate catecholamine release from fetal adrenomedullary cells in vitro suggest that VIP may be an important modulator of medullary catecholamine secretion during fetal life. Catecholamines 221-234 vasoactive intestinal peptide Homo sapiens 80-83 3702592-3 1986 When an animal is subjected to a stressful stimulus, it would be expected that the increase in plasma stimulus, it would be expected that the increase in plasma catecholamines originating from the adrenal medulla and/or the sympathetic nervous system would result in a stimulation of pineal NAT activity. Catecholamines 161-175 N-acetyltransferase 1 Rattus norvegicus 291-294 2872622-1 1986 We have compared the pattern of neural catecholamine fluorescence with that of immunoreactivity for the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) in dog atrium, which is innervated by noradrenergic nerves, and in dog kidney, which is thought to be supplied by dopaminergic nerves as well. Catecholamines 104-117 dopa decarboxylase Canis lupus familiaris 169-187 2871556-1 1986 Tyrosine hydroxylase [TyrOHase; tyrosine 3-monooxygenase; L-tyrosine,tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] and phenylethanolamine N-methyltransferase, EC 2.1.1.28) are involved in catecholamine biosynthesis and are considered soluble proteins. Catecholamines 217-230 tyrosine hydroxylase Homo sapiens 32-56 3007908-3 1986 Bovine ANF was separated by carboxymethyl agarose gel chromatography from catecholamines and major protein contaminants. Catecholamines 74-88 natriuretic peptide A Bos taurus 7-10 3698511-2 1986 Four incremental infusion rates (4, 10, 25 and 62.5 ng min-1 kg-1) produced circulating catecholamine concentrations within the physiological range. Catecholamines 88-101 CD59 molecule (CD59 blood group) Homo sapiens 55-65 3514428-7 1986 Direct stimulation of renin-containing cells by catecholamines is suggested as the cause of the hyperplasia. Catecholamines 48-62 renin Homo sapiens 22-27 2871139-5 1986 The results show that there are two types of PNMT-containing cells: those containing PNMT exclusively and those containing PNMT with two other catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC), but not dopamine beta-hydroxylase (DBH). Catecholamines 143-156 phenylethanolamine-N-methyltransferase Rattus norvegicus 45-49 3945641-0 1986 Effect of various catecholamine antagonists on prolactin secretion in conscious male rabbits. Catecholamines 18-31 prolactin Oryctolagus cuniculus 47-56 3517886-6 1986 These findings indicate that LHRH could exert its behavioral effects through an inhibitory action upon brain catecholamine synthesis. Catecholamines 109-122 gonadotropin releasing hormone 1 Rattus norvegicus 29-33 3018232-1 1986 We have studied the influence of the renin-angiotensin system on the control of catecholamine release from innervated and denervated adrenal glands of anaesthetized dogs. Catecholamines 80-93 renin Canis lupus familiaris 37-42 3012514-6 1986 It was concluded that the role of catecholamines was not restricted only to the activation of LH-RH release from the terminals at the level of the median eminence but was also necessary at the level of LH-RH producing cells of the hypothalamus. Catecholamines 34-48 gonadotropin releasing hormone 1 Rattus norvegicus 94-99 3012514-6 1986 It was concluded that the role of catecholamines was not restricted only to the activation of LH-RH release from the terminals at the level of the median eminence but was also necessary at the level of LH-RH producing cells of the hypothalamus. Catecholamines 34-48 gonadotropin releasing hormone 1 Rattus norvegicus 202-207 3518707-0 1986 Decreased tyrosine kinase activity of insulin receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro. Catecholamines 114-127 insulin receptor Rattus norvegicus 38-54 3080808-2 1986 We show that methylphenylpyridine (MPP+), an active metabolite of MPTP which is accumulated intraneuronally by the catecholamine uptake system, binds with high affinity to melanin and neuromelanin. Catecholamines 115-128 M-phase phosphoprotein 6 Homo sapiens 35-38 3518707-4 1986 (1) Insulin increased the tyrosine autophosphorylation of the insulin receptor kinase from catecholamine-treated cells only 4-fold, compared with a 12-fold stimulation in control cells. Catecholamines 91-104 insulin receptor Rattus norvegicus 62-78 3518707-7 1986 The insulin receptor from catecholamine treated cells bound 25-50% of the amount of insulin bound by the receptor from control cells at insulin concentrations of 10 pM-0.1 muM. Catecholamines 26-39 insulin receptor Rattus norvegicus 4-20 3518707-8 1986 Part of the impaired insulin-responsiveness of the receptor kinase of catecholamine-treated cells is therefore explained by impaired binding properties; however, an additional inhibition of the kinase activity of the insulin receptor from catecholamine-treated cells is evident. Catecholamines 70-83 insulin receptor Rattus norvegicus 217-233 3949007-5 1986 These findings show good agreement with recently reported findings in leaky adrenal medulla cells, and suggest the involvement of PLA2 in the release of catecholamines. Catecholamines 153-167 phospholipase A2 group IB Homo sapiens 130-134 3518707-8 1986 Part of the impaired insulin-responsiveness of the receptor kinase of catecholamine-treated cells is therefore explained by impaired binding properties; however, an additional inhibition of the kinase activity of the insulin receptor from catecholamine-treated cells is evident. Catecholamines 239-252 insulin receptor Rattus norvegicus 217-233 3949007-2 1986 The possible involvement of phospholipase A2 (PLA2) in the release of catecholamines was examined in a cell-free model system, using isolated chromaffin granules and plasma membranes of adrenal medulla cells. Catecholamines 70-84 phospholipase A2 group IB Homo sapiens 28-44 3518707-13 1986 (5) We conclude from the data that catecholamine treatment of rat adipocytes modulates the kinase activity of the insulin receptor by increasing its Km for ATP and that this is part of the mechanism leading to insulin-resistance in these cells. Catecholamines 35-48 insulin receptor Rattus norvegicus 114-130 3949007-2 1986 The possible involvement of phospholipase A2 (PLA2) in the release of catecholamines was examined in a cell-free model system, using isolated chromaffin granules and plasma membranes of adrenal medulla cells. Catecholamines 70-84 phospholipase A2 group IB Homo sapiens 46-50 2872048-1 1986 A single injection of reserpine causes a long lasting enhancement of the activity of tyrosine hydroxylase (TH), the enzyme catalyzing the rate-limiting step in the biosynthesis of catecholamines. Catecholamines 180-194 tyrosine hydroxylase Rattus norvegicus 85-105 3080883-6 1986 Catecholamine-induced changes in precapillary sphincter tone could affect the delivery of triglyceride-rich lipoproteins to endothelial lipase, cause changes in capillary endothelial surface area for lipase-binding sites, and/or modulate the synthesis of lipoprotein lipase by adipocytes and myocytes. Catecholamines 0-13 lipoprotein lipase Homo sapiens 255-273 2868656-8 1986 These data, which confirm previous reports of serum lipid changes during antihypertensive therapy, suggest that alpha1 blockers may interfere with lipoprotein lipase, possibly by reducing its catecholamine-mediated inactivation. Catecholamines 192-205 lipoprotein lipase Homo sapiens 147-165 2872048-1 1986 A single injection of reserpine causes a long lasting enhancement of the activity of tyrosine hydroxylase (TH), the enzyme catalyzing the rate-limiting step in the biosynthesis of catecholamines. Catecholamines 180-194 tyrosine hydroxylase Rattus norvegicus 107-109 3945051-13 1986 The LM protein, which appears to be a single, unique polypeptide induced by IPR in the submandibular glands of developing and adult rats, will be useful in studies examining the effects of catecholamine beta-agonists on gene expression in an exocrine cell. Catecholamines 189-202 cystatin S Rattus norvegicus 4-14 2867127-0 1986 Nerve growth factor and dexamethasone modulate synthesis and storage of catecholamines in cultured rat adrenal medullary cells: dependence on postnatal age. Catecholamines 72-86 nerve growth factor Rattus norvegicus 0-19 3946504-0 1986 Interrelationship between amniotic fluid C-peptide and catecholamines in the last trimester of diabetic pregnancy. Catecholamines 55-69 insulin Homo sapiens 41-50 3946504-4 1986 Mean amniotic fluid catecholamine concentrations were lower, although not statistically so, in both insulin-dependent and gestational diabetic women than in control women. Catecholamines 20-33 insulin Homo sapiens 100-107 3532664-5 1986 The IDM"s are able to respond to both physiologic and metabolic stress with an increased catecholamine secretion during the first hours of life, and the catecholamines seem to counteract the inhibitory effect of insulin on lipolysis and, at least partly, to oppose the blood glucose lowering effect of insulin. Catecholamines 153-167 insulin Homo sapiens 212-219 3532664-5 1986 The IDM"s are able to respond to both physiologic and metabolic stress with an increased catecholamine secretion during the first hours of life, and the catecholamines seem to counteract the inhibitory effect of insulin on lipolysis and, at least partly, to oppose the blood glucose lowering effect of insulin. Catecholamines 153-167 insulin Homo sapiens 302-309 2872999-1 1986 Phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH) are consecutive enzymes in the metabolic pathway leading to the production of catecholamine neurotransmitters. Catecholamines 140-153 phenylalanine hydroxylase Homo sapiens 0-25 3790744-9 1986 The results suggest that the O-methylation of catecholamines can occur in both medial and endothelial structures in this blood vessel and support the results of immunohistochemical studies that suggested a presence of catechol-O-methyltransferase in vascular endothelial structures. Catecholamines 46-60 catechol O-methyltransferase Oryctolagus cuniculus 218-246 2870811-6 1986 Cells exhibited intense histofluorescence for catecholamines even after three weeks in vitro in the presence of NGF and positive staining for tyrosine hydroxylase and dopamine beta hydroxylase could be detected by immunocytochemistry. Catecholamines 46-60 nerve growth factor Homo sapiens 112-115 3524698-2 1986 As high amounts of catecholamines are released in the newborn at delivery, probably following the stress of parturition, a similar release of met-enkephalin and other pro-enkephalin A deriving peptides from the newborn chromaffin tissue may be hypothesized. Catecholamines 19-33 proopiomelanocortin Homo sapiens 142-156 3006842-1 1986 Catecholamines seem to inhibit transmission through airway parasympathetic ganglia by two mechanisms: Beta-2-adrenoceptor stimulation induces a ganglionic inhibition characterised by: slow onset, effect mainly on neural signals of high frequency, localisation to the presynaptic nerve terminal in the ganglion (inhibition of transmittor release). Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 102-121 3091249-5 1986 These findings suggest that catecholamine-containing neurons, probably noradrenergic, may innervate TRH neurons to regulate TRH secretion via synapses with other unknown neurons in the rat PVN. Catecholamines 28-41 thyrotropin releasing hormone Rattus norvegicus 100-103 3091249-5 1986 These findings suggest that catecholamine-containing neurons, probably noradrenergic, may innervate TRH neurons to regulate TRH secretion via synapses with other unknown neurons in the rat PVN. Catecholamines 28-41 thyrotropin releasing hormone Rattus norvegicus 124-127 2872999-1 1986 Phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH) are consecutive enzymes in the metabolic pathway leading to the production of catecholamine neurotransmitters. Catecholamines 140-153 phenylalanine hydroxylase Homo sapiens 27-30 2872999-1 1986 Phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH) are consecutive enzymes in the metabolic pathway leading to the production of catecholamine neurotransmitters. Catecholamines 140-153 tyrosine hydroxylase Homo sapiens 36-56 3512264-10 1986 The association after swimming compared to running of a decreased PRA and an enhanced catecholamine response rule out a strict dependence of renin release under the effect of plasma catecholamines and is evidence of the major role of neural pathways for renin secretion during physical exercise. Catecholamines 86-99 renin Homo sapiens 254-259 3000912-6 1986 It is also possible that the increase in adrenal catecholamine secretion after ACTH may be due to ACTH augmentation of catecholamine secretion by endogenous opioids such as beta-endorphin. Catecholamines 49-62 proopiomelanocortin Homo sapiens 79-83 3596322-3 1986 Liver ODC activity declined (P less than .01) with increasing age and was reduced (P less than .0001) at each age compared with control values after maternal deprivation for 16 h. Liver weight and plasma glucose were reduced (P less than .01) by maternal deprivation, while plasma catecholamines were unchanged and plasma growth hormone tended to be reduced, although the difference between means for deprived and control animals was not significant (P greater than .05). Catecholamines 281-295 ornithine decarboxylase 1 Sus scrofa 6-9 3721190-1 1986 The effect of a single administration of catecholamines on ornithine decarboxylase activity and polyamine biosynthesis in the rat spleen was investigated. Catecholamines 41-55 ornithine decarboxylase 1 Rattus norvegicus 59-82 3721190-5 1986 alpha- and beta-adrenergic antagonists prevented the ODC increase by catecholamines to a different extent. Catecholamines 69-83 ornithine decarboxylase 1 Rattus norvegicus 53-56 3000912-6 1986 It is also possible that the increase in adrenal catecholamine secretion after ACTH may be due to ACTH augmentation of catecholamine secretion by endogenous opioids such as beta-endorphin. Catecholamines 49-62 proopiomelanocortin Homo sapiens 98-102 3000912-6 1986 It is also possible that the increase in adrenal catecholamine secretion after ACTH may be due to ACTH augmentation of catecholamine secretion by endogenous opioids such as beta-endorphin. Catecholamines 119-132 proopiomelanocortin Homo sapiens 79-83 3000912-6 1986 It is also possible that the increase in adrenal catecholamine secretion after ACTH may be due to ACTH augmentation of catecholamine secretion by endogenous opioids such as beta-endorphin. Catecholamines 119-132 proopiomelanocortin Homo sapiens 98-102 3014371-2 1986 Performance was better in transfer situations, in high MAO-high DBH subjects (high catecholamine turnover rate? Catecholamines 83-96 dopamine beta-hydroxylase Homo sapiens 64-67 2427735-2 1986 Chromaffin cells adapt to altered functional requirements by increasing the synthesis of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 144-157 tyrosine hydroxylase Rattus norvegicus 89-109 2427735-2 1986 Chromaffin cells adapt to altered functional requirements by increasing the synthesis of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 144-157 tyrosine hydroxylase Rattus norvegicus 111-113 20493065-0 1986 Studies on neuropeptide Y-catecholamine interactions in the hypothalamus and in the forebrain of the male rat. Catecholamines 26-39 neuropeptide Y Rattus norvegicus 11-25 3785576-1 1986 Many studies suggest that the hypothalamic opiate system modulates the secretion of LH and prolactin (PRL) by its effects on catecholamine release. Catecholamines 125-138 prolactin Rattus norvegicus 91-100 3785576-1 1986 Many studies suggest that the hypothalamic opiate system modulates the secretion of LH and prolactin (PRL) by its effects on catecholamine release. Catecholamines 125-138 prolactin Rattus norvegicus 102-105 20493139-7 1986 Following stimulation of catecholamine secretion, DBH and DBH/anti-DBH complexes both disappeared from the cell surface at similar rates. Catecholamines 25-38 dopamine beta-hydroxylase Bos taurus 58-61 20493139-7 1986 Following stimulation of catecholamine secretion, DBH and DBH/anti-DBH complexes both disappeared from the cell surface at similar rates. Catecholamines 25-38 dopamine beta-hydroxylase Bos taurus 58-61 3513120-2 1986 Insulin dosages of 3 IU/kg in rats and 0.75 IU/kg in dogs were found to cause changes of comparable amplitude and kinetics in plasma glucose and catecholamine levels in both species. Catecholamines 145-158 insulin Canis lupus familiaris 0-7 2870726-0 1986 [Topography of the catecholamine neurons in the brain stem of the human fetus: an immunohistochemical study using antibodies to tyrosine hydroxylase]. Catecholamines 19-32 tyrosine hydroxylase Homo sapiens 128-148 2870726-1 1986 Immunohistochemistry using antibodies to tyrosine hydroxylase (TH), a rate-limiting enzyme which catalyzes the initial step in the catecholamine synthesizing pathway, has been widely accepted as one of the methods for identification of catecholamine neurons in the nervous system. Catecholamines 131-144 tyrosine hydroxylase Homo sapiens 41-61 2870726-1 1986 Immunohistochemistry using antibodies to tyrosine hydroxylase (TH), a rate-limiting enzyme which catalyzes the initial step in the catecholamine synthesizing pathway, has been widely accepted as one of the methods for identification of catecholamine neurons in the nervous system. Catecholamines 131-144 tyrosine hydroxylase Homo sapiens 63-65 2870726-1 1986 Immunohistochemistry using antibodies to tyrosine hydroxylase (TH), a rate-limiting enzyme which catalyzes the initial step in the catecholamine synthesizing pathway, has been widely accepted as one of the methods for identification of catecholamine neurons in the nervous system. Catecholamines 236-249 tyrosine hydroxylase Homo sapiens 41-61 2870726-1 1986 Immunohistochemistry using antibodies to tyrosine hydroxylase (TH), a rate-limiting enzyme which catalyzes the initial step in the catecholamine synthesizing pathway, has been widely accepted as one of the methods for identification of catecholamine neurons in the nervous system. Catecholamines 236-249 tyrosine hydroxylase Homo sapiens 63-65 3513267-10 1986 During manipulation of the tumors upon surgical removal, there was a marked increase in plasma NPY-LI in parallel with the raise in catecholamines and in blood pressure. Catecholamines 132-146 neuropeptide Y Homo sapiens 95-98 3002132-9 1985 Since both the ACTH secretion and memory function may be dependent upon the intracerebral catecholamines, the present findings may reflect variations in central monoaminergic receptor function. Catecholamines 90-104 proopiomelanocortin Homo sapiens 15-19 4067488-1 1985 In this study, aimed at investigating whether dopaminergic regulation of prolactin could be implicated in the hypoprolactinaemia observed in the IPL nude rat, dopaminergic inhibition of prolactin was suppressed using a catecholamine synthesis inhibitor alpha-methyltyrosine (MT) and a dopaminergic antagonist sulpiride. Catecholamines 219-232 prolactin Rattus norvegicus 73-82 3936737-3 1985 Met-enkephalin, catecholamines and prostaglandin E (PGE) have all been reported to inhibit the acute insulin response to glucose in normal humans. Catecholamines 16-30 insulin Homo sapiens 101-108 3830349-0 1985 Central vasopressin in the modulation of catecholamine release in conscious rats. Catecholamines 41-54 arginine vasopressin Rattus norvegicus 8-19 2935570-18 1985 Vasopressin"s central actions on the cardiovascular medullary centres, the baroreflex, the autonomic nervous system and catecholamine metabolism may also be involved in some hypertensive processes. Catecholamines 120-133 arginine vasopressin Homo sapiens 0-11 2414402-1 1985 Substance P is known to modulate acetylcholine-induced catecholamine release from adrenal chromaffin cells. Catecholamines 55-68 tachykinin precursor 1 Bos taurus 0-11 4079740-1 1985 Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E). Catecholamines 231-245 dopamine beta-hydroxylase Homo sapiens 56-81 4079740-1 1985 Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E). Catecholamines 231-245 dopamine beta-hydroxylase Homo sapiens 83-86 4054700-6 1985 These data show that basal gastrin concentration is raised by central catecholamine augmentation; but gastric acid secretion seems to be influenced by changes of peripheral catecholamine concentrations. Catecholamines 70-83 gastrin Homo sapiens 27-34 2415978-1 1985 Corticotropin (ACTH)-releasing factor, vasoactive intestinal peptide, and catecholamines--hormones that stimulate ACTH secretion and cAMP generation--increased cytosolic calcium in AtT-20 cells. Catecholamines 74-88 pro-opiomelanocortin-alpha Mus musculus 114-118 3000362-7 1985 Our results indicate that, in rat platelets, catecholamines are able to counteract, via alpha2-receptors, the beta-adrenoceptor-mediated inhibition of thrombin-induced phosphatidic acid formation. Catecholamines 45-59 coagulation factor II Rattus norvegicus 151-159 3909741-0 1985 Effects of calcium and limited proteolysis on membrane-bound and releasable dopamine beta-hydroxylase in adrenomedullary catecholamine granules. Catecholamines 121-134 dopamine beta-hydroxylase Bos taurus 76-101 3002668-1 1985 As the interactions of iodothyronines on adrenergic and vipergic receptors are not clear, the effect of exogenous T3 and T4 on catecholamine- and VIP-induced cAMP accumulation in human normal thyroid cells after eight days of primary culture has been investigated. Catecholamines 127-140 cathelicidin antimicrobial peptide Homo sapiens 158-162 3900292-2 1985 Catecholamine-depleting drugs, such as tetrabenazine, and cyclic nucleotide-elevating drugs, including forskolin, 8-bromo-cyclic AMP, and theophylline, increase chromaffin cell enkephalin-containing peptide levels but fail to increase dopamine beta-hydroxylase. Catecholamines 0-13 dopamine beta-hydroxylase Homo sapiens 235-260 3003588-8 1985 Haloperidol (a dopamine antagonist) and alpha-methyl-p-tyrosine (a catecholamine synthesis inhibitor) potentiated the R-PIA-induced effects. Catecholamines 67-80 ribose 5-phosphate isomerase A Rattus norvegicus 118-123 4043294-2 1985 Results indicate that the sources of this catecholamine innervation are widespread, originating from cell bodies throughout the brain stem including the medullary catecholamine cell groups as well as the noradrenergic nuclei of the dorsolateral pons, including locus ceruleus, subceruleus, Kolliker-Fuse, and the parabrachial nuclei. Catecholamines 42-55 Polykaryocytosis inducer Homo sapiens 299-303 3840999-1 1985 Venous plasma levels of neuropeptide Y-like immunoreactivity (with chromatographic properties of synthetic neuropeptide Y) increased in parallel with catecholamines, heart rate and blood pressure during graded physical exercise in man. Catecholamines 150-164 neuropeptide Y Homo sapiens 24-38 4094677-6 1985 In connection with the aforementioned, we were interested in studying the activity of acetylcholinesterase (AChE) and monoamine oxidase (MAO), which participate in the metabolism of acetylcholine and catecholamines, respectively, in the process of a change in the food-motivated behavior of animals in the micro- and ultrastructures of certain hypothalamic nuclei and the cerebral cortex. Catecholamines 200-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 4094677-6 1985 In connection with the aforementioned, we were interested in studying the activity of acetylcholinesterase (AChE) and monoamine oxidase (MAO), which participate in the metabolism of acetylcholine and catecholamines, respectively, in the process of a change in the food-motivated behavior of animals in the micro- and ultrastructures of certain hypothalamic nuclei and the cerebral cortex. Catecholamines 200-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 2867499-5 1985 Nerve fibers containing VIP-like immunoreactive material have been reported in the adrenal medulla and in other catecholamine (CA)- storing tissues. Catecholamines 112-125 vasoactive intestinal peptide Rattus norvegicus 24-27 3875898-2 1985 The reagents recognized different populations of neurons: those that recognized MAO A were located in cell groups containing catecholamines, including the substantia nigra, nucleus locus coeruleus, nucleus subcoeruleus, and the periventricular region of the hypothalamus, whereas those that recognized MAO B were observed in serotonin regions, including the nucleus raphe dorsalis and nucleus centralis superior. Catecholamines 125-139 monoamine oxidase A Homo sapiens 80-85 2416014-10 1985 Other mechanisms for GAL action, such as influence on neuronal uptake and catecholamine metabolism, cannot be ruled out. Catecholamines 74-87 galanin and GMAP prepropeptide Rattus norvegicus 21-24 2863827-0 1985 Effect of various catecholamine antagonists on prolactin secretion in conscious male rabbits. Catecholamines 18-31 prolactin Oryctolagus cuniculus 47-56 2864786-16 1985 In addition, catecholamine (CA) and enkephalin immuno-reactive nerve terminal networks exist in high densities within the nucleus tractus solitarius (nTS) of the medulla oblongata and may therefore interact with somatostatin nerve terminals in regulation of respiratory activity (Kalia et al. Catecholamines 13-26 somatostatin Rattus norvegicus 212-224 2863177-1 1985 We found that the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) (EC 1.14.16.2), dopamine beta-hydroxylase (EC 1.14.17.1), and phenylethanolamine N-methyltransferase (EC 2.1.1.28) share similar protein domains in their primary structures and that they share common gene coding sequences. Catecholamines 18-31 tyrosine hydroxylase Homo sapiens 53-73 3840322-5 1985 In the adrenal gland the NPY-LI was mainly located in the catecholamine-storing chromaffin-granule fraction and also to a smaller extent in lighter fractions. Catecholamines 58-71 neuropeptide Y Homo sapiens 25-28 3840322-0 1985 Subcellular storage and axonal transport of neuropeptide Y (NPY) in relation to catecholamines in the cat. Catecholamines 80-94 neuropeptide Y Homo sapiens 44-58 3840322-0 1985 Subcellular storage and axonal transport of neuropeptide Y (NPY) in relation to catecholamines in the cat. Catecholamines 80-94 neuropeptide Y Homo sapiens 60-63 2863177-1 1985 We found that the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) (EC 1.14.16.2), dopamine beta-hydroxylase (EC 1.14.17.1), and phenylethanolamine N-methyltransferase (EC 2.1.1.28) share similar protein domains in their primary structures and that they share common gene coding sequences. Catecholamines 18-31 tyrosine hydroxylase Homo sapiens 75-77 2863177-1 1985 We found that the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) (EC 1.14.16.2), dopamine beta-hydroxylase (EC 1.14.17.1), and phenylethanolamine N-methyltransferase (EC 2.1.1.28) share similar protein domains in their primary structures and that they share common gene coding sequences. Catecholamines 18-31 dopamine beta-hydroxylase Homo sapiens 95-120 2863177-1 1985 We found that the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) (EC 1.14.16.2), dopamine beta-hydroxylase (EC 1.14.17.1), and phenylethanolamine N-methyltransferase (EC 2.1.1.28) share similar protein domains in their primary structures and that they share common gene coding sequences. Catecholamines 18-31 phenylethanolamine N-methyltransferase Homo sapiens 141-179 2862637-6 1985 Thus, the effects of spike concentrations of GH on plasma serotonin and catecholamines are apparently mediated by SRIF, a novel and unexpected function for a hormone that is known as an inhibitor of GH secretion. Catecholamines 72-86 somatotropin Canis lupus familiaris 45-47 4088235-2 1985 We studied the mechanism of gastrin release following insulin-induced hypoglycemia with respect to plasma catecholamines in mongrel dogs. Catecholamines 106-120 gastrin Canis lupus familiaris 28-35 2863972-1 1985 Beta 2-receptor stimulation is required for catecholamine-induced hypokalemia to occur. Catecholamines 44-57 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 0-6 3934717-5 1985 These results suggest that the TRH content of certain brain regions may be regulated by catecholamine neurotransmitters. Catecholamines 88-101 thyrotropin releasing hormone Rattus norvegicus 31-34 2863972-3 1985 Catecholamine-induced hypokalemia can be prevented by selective beta 2 blockade, which does not abolish the inotropic effect of epinephrine. Catecholamines 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 64-70 2861818-2 1985 The influence has been studied of 11 phenothiazine drugs on the oxidation of the catecholamine neurotransmitters noradrenaline and dopamine, catalyzed by human ceruloplasmin. Catecholamines 81-94 ceruloplasmin Homo sapiens 160-173 3840321-1 1985 Neuropeptide Y (NPY) is a recently isolated vasoactive peptide, which is present, together with catecholamines, in sympathetic nerves and in the adrenal medulla. Catecholamines 96-110 pro-neuropeptide Y Cavia porcellus 0-14 3840321-1 1985 Neuropeptide Y (NPY) is a recently isolated vasoactive peptide, which is present, together with catecholamines, in sympathetic nerves and in the adrenal medulla. Catecholamines 96-110 pro-neuropeptide Y Cavia porcellus 16-19 2864260-3 1985 These results indicate that the action of SCH-23390 to antagonize D-2 dopamine receptor actions is dependent upon functional catecholamine-containing neurons. Catecholamines 125-138 dopamine receptor D2 Rattus norvegicus 66-87 2864260-6 1985 These data suggest that D-1 receptor sites modulate D-2 dopamine receptor function through a mechanism dependent upon functionally intact catecholamine-containing neurons. Catecholamines 138-151 dopamine receptor D2 Rattus norvegicus 52-73 4036531-8 1985 Therapeutic approaches to the treatment of catecholamine-induced heart failure may be potassium and magnesium supplements and possibly drugs reducing circulating angiotensin II activities. Catecholamines 43-56 angiotensinogen Homo sapiens 162-176 3896393-1 1985 Acute insulin stress increased plasma catecholamine levels in both the Syrian hamster and albino rat within 3 h after an intraperitoneal injection of either 5 or 10 units of insulin. Catecholamines 38-51 insulin Mesocricetus auratus 6-13 3895816-8 1985 These findings indicate that the catecholamines counteracts the inhibitory effect of insulin on lipolysis in IDMs. Catecholamines 33-47 insulin Homo sapiens 85-92 3930975-1 1985 Isolated gastric glands from the rabbit were used for studying the effect of catecholamines on the release of pepsinogen. Catecholamines 77-91 pepsin II-2/3 Oryctolagus cuniculus 110-120 4067816-7 1985 From the above results, it was suggested that the antinociceptive effect of NAGA may involve the participation of endogenous opioid peptides and endogenous catecholamines. Catecholamines 156-170 N-acetyl galactosaminidase, alpha Mus musculus 76-80 2864960-2 1985 Two enzymes of the biosynthetic pathway of the catecholamines, tyrosine-hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), were characterized as translation products after immunoprecipitation by specific antisera and electrophoretic analysis. Catecholamines 47-61 dopamine beta-hydroxylase Homo sapiens 93-118 3906595-3 1985 The NPY system is of particular interest as the peptide coexists with catecholamines in the central and sympathetic nervous system and adrenal medulla. Catecholamines 70-84 neuropeptide Y Homo sapiens 4-7 2860926-5 1985 Thus, catecholamine-triggered beta 2-receptors coupled to adenyl cyclase are involved in the regulation of diamine oxidase activity in normal and hypertrophic rat kidney. Catecholamines 6-19 amine oxidase, copper containing 1 Rattus norvegicus 107-122 2408480-2 1985 We examined the long-term effects of catecholamines on the insulin-sensitive 2-deoxyglucose (dGlc) uptake in cultured 3T3-L1 adipocytes. Catecholamines 37-51 insulin Homo sapiens 59-66 2864960-2 1985 Two enzymes of the biosynthetic pathway of the catecholamines, tyrosine-hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), were characterized as translation products after immunoprecipitation by specific antisera and electrophoretic analysis. Catecholamines 47-61 dopamine beta-hydroxylase Homo sapiens 120-123 3929146-4 1985 It is suggested that GABA uptake together with catabolic action of GABA-transaminase, also found in this tissue, could be regulating the GABA levels disposable for the proposed modulator role on catecholamine secretion of this amino acid in adrenal medulla. Catecholamines 195-208 4-aminobutyrate aminotransferase Bos taurus 67-84 2410814-1 1985 Administration of 10 micrograms of substance P intrathecally to the spinal T9 level of the adult rat, anaesthetized with urethane, provoked an increase in free catecholamines in plasma taken from the inferior vena cava. Catecholamines 160-174 tachykinin precursor 1 Homo sapiens 35-46 2410814-3 1985 Differences between the values of free catecholamines in animals given substance P vs those given vehicle only were statistically significant at 1 and 10 min postinjection, but not at 30 min. Catecholamines 39-53 tachykinin precursor 1 Homo sapiens 71-82 4041988-1 1985 The effects of a spike concentration of growth hormone (GH) on hepatic portal and peripheral levels of free serotonin and catecholamines were studied by improved radioenzymatic methods in trained, conscious, normal, adult dogs fitted with an indwelling portal catheter. Catecholamines 122-136 somatotropin Canis lupus familiaris 40-54 3994013-5 1985 min-1) affect the catecholamine stress response to surgery differently. Catecholamines 18-31 CD59 molecule (CD59 blood group) Homo sapiens 0-5 3927322-6 1985 It can be concluded from the data that the increased locomotion induced by TRH and the TRH-ethanol combination does not depend upon endogenous monoamines, whereas the sedative effects of ethanol are apparently influenced by alterations in brain catecholamine function. Catecholamines 245-258 thyrotropin releasing hormone Rattus norvegicus 87-90 2860551-2 1985 Previous studies demonstrated that 2 hr without food causes a loss of hepatic ODC induction after glucagon or catecholamine injection. Catecholamines 110-123 ornithine decarboxylase 1 Rattus norvegicus 78-81 2992626-3 1985 Experiments with serine protease inhibitors suggest the possibility that mechanistic features of the interaction of angiotensin with its receptors may apply to other "phenoxyl" hormones including certain peptides, steroids and catecholamines. Catecholamines 227-241 coagulation factor II, thrombin Homo sapiens 17-32 4041988-1 1985 The effects of a spike concentration of growth hormone (GH) on hepatic portal and peripheral levels of free serotonin and catecholamines were studied by improved radioenzymatic methods in trained, conscious, normal, adult dogs fitted with an indwelling portal catheter. Catecholamines 122-136 somatotropin Canis lupus familiaris 56-58 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 7-20 catechol-O-methyltransferase Rattus norvegicus 63-91 3997234-2 1985 Chromogranin A is the major catecholamine storage vesicle soluble protein costored and coreleased by exocytosis with catecholamines. Catecholamines 28-41 chromogranin A Homo sapiens 0-14 3997234-2 1985 Chromogranin A is the major catecholamine storage vesicle soluble protein costored and coreleased by exocytosis with catecholamines. Catecholamines 117-131 chromogranin A Homo sapiens 0-14 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 7-20 catechol-O-methyltransferase Rattus norvegicus 184-188 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 63-91 2862239-2 1985 As the catecholamine formed appears to be a good substrate for catechol-O-methyltransferase, in-vivo catecholamine formation in rats from 3-PPP was only detectable after inhibition of COMT by tropolone. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 184-188 2581649-1 1985 Substance P (SP) has two distinct actions on catecholamine (CA) release from cultured bovine adrenal chromaffin cells: SP inhibits acetylcholine (ACh)- or nicotine-induced [3H]norepinephrine ([3H]NE) release; and SP protects against desensitization of ACh- or nicotine-induced [3H]NE release. Catecholamines 45-58 tachykinin precursor 1 Bos taurus 0-16 2415951-0 1985 Organization of LHRH cells: differential apposition of neurotensin, substance P and catecholamine axons. Catecholamines 84-97 gonadotropin releasing hormone 1 Mus musculus 16-20 2415951-1 1985 A wealth of evidence suggests that catecholamines (particularly norepinephrine) influence gonadotropin secretion via a direct interaction with the LHRH neurons. Catecholamines 35-49 gonadotropin releasing hormone 1 Mus musculus 147-151 2859859-1 1985 Ornithine decarboxylase (ODC) and tyrosine hydroxylase (TH), the first enzymes in the polyamine and catecholamine biosynthetic pathways, respectively, are induced in the adrenal gland of the rat through the application of stressors or dopamine agonists. Catecholamines 100-113 ornithine decarboxylase 1 Rattus norvegicus 0-23 2859859-1 1985 Ornithine decarboxylase (ODC) and tyrosine hydroxylase (TH), the first enzymes in the polyamine and catecholamine biosynthetic pathways, respectively, are induced in the adrenal gland of the rat through the application of stressors or dopamine agonists. Catecholamines 100-113 ornithine decarboxylase 1 Rattus norvegicus 25-28 2859859-1 1985 Ornithine decarboxylase (ODC) and tyrosine hydroxylase (TH), the first enzymes in the polyamine and catecholamine biosynthetic pathways, respectively, are induced in the adrenal gland of the rat through the application of stressors or dopamine agonists. Catecholamines 100-113 tyrosine hydroxylase Rattus norvegicus 34-54 3874083-5 1985 The results suggest that MAO-B and the catecholamine uptake system may be critically involved at certain steps in the neurotoxic action of MPTP on catecholamine neurons. Catecholamines 147-160 monoamine oxidase B Mus musculus 25-30 2859859-1 1985 Ornithine decarboxylase (ODC) and tyrosine hydroxylase (TH), the first enzymes in the polyamine and catecholamine biosynthetic pathways, respectively, are induced in the adrenal gland of the rat through the application of stressors or dopamine agonists. Catecholamines 100-113 tyrosine hydroxylase Rattus norvegicus 56-58 2581649-1 1985 Substance P (SP) has two distinct actions on catecholamine (CA) release from cultured bovine adrenal chromaffin cells: SP inhibits acetylcholine (ACh)- or nicotine-induced [3H]norepinephrine ([3H]NE) release; and SP protects against desensitization of ACh- or nicotine-induced [3H]NE release. Catecholamines 45-58 tachykinin precursor 1 Bos taurus 13-15 2581649-1 1985 Substance P (SP) has two distinct actions on catecholamine (CA) release from cultured bovine adrenal chromaffin cells: SP inhibits acetylcholine (ACh)- or nicotine-induced [3H]norepinephrine ([3H]NE) release; and SP protects against desensitization of ACh- or nicotine-induced [3H]NE release. Catecholamines 45-58 tachykinin precursor 1 Bos taurus 119-121 3156762-0 1985 Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells. Catecholamines 28-41 plasminogen activator, tissue type Bos taurus 71-74 3980483-7 1985 We propose that in addition to the dopamine beta-hydroxylase which is found in catecholamine storage vesicles and released during stimulus-coupled exocytosis, PC12 cells also have a constitutive secretory pathway for dopamine beta-hydroxylase and that the enzyme released by this second pathway is sulfated. Catecholamines 79-92 dopamine beta-hydroxylase Rattus norvegicus 35-60 3156762-1 1985 The phorbol ester, 4 beta-phorbol 12-myristate acetate (TPA), increased the extent of catecholamine release induced by Ca2+, without affecting the basal release response in digitonin-permeabilized chromaffin cells. Catecholamines 86-99 plasminogen activator, tissue type Bos taurus 56-59 3891048-7 1985 It appears that both the adrenal catecholamines and adrenergic innervation to the pancreas contribute to the prevention of a rise in insulin concentrations during exercise in sheep. Catecholamines 33-47 LOC105613195 Ovis aries 133-140 2993098-7 1985 Indirectly, an increase in systolic Ca2+ can amplify the primary effect of catecholamine on the Ca2+ pumping ATPase and probably also on the Na+/Ca2+ antiporter through Ca2+-calmodulin-dependent phosphorylation of membrane proteins. Catecholamines 75-88 calmodulin 1 Homo sapiens 174-184 2989015-1 1985 In order to evaluate the role of beta-receptor mediated effects of catecholamines in the metabolic deterioration following insulin withdrawal in insulin-dependent diabetic patients we have measured in 5 patients metabolic substrate and hormone concentrations during a 6 hours arrest of insulin infusion, without or with a simultaneous infusion of propranolol. Catecholamines 67-81 insulin Homo sapiens 123-130 3971933-4 1985 The ability of the catecholamines to stimulate androgen production was dependent on the continuous presence of hCG. Catecholamines 19-33 hypertrichosis 2 (generalised, congenital) Homo sapiens 111-114 3971933-8 1985 The acquisition of catecholamine responsiveness was specific to hCG; if theca-interstitial cells were induced to differentiate with either prostaglandin E2 or cholera toxin, then isoproterenol did not enhance androgen synthesis. Catecholamines 19-32 hypertrichosis 2 (generalised, congenital) Homo sapiens 64-67 2858497-6 1985 In this study the location of catecholamine-synthesizing enzymes was examined in the serial sections of the caudal medulla oblongata of the rat: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 30-43 tyrosine hydroxylase Rattus norvegicus 145-165 2858582-1 1985 Chronic hypotension and hypoglycemia are known to increase the capacity for catecholamine biosynthesis in the rat adrenal medulla by increasing the maximal velocity of the rate-limiting enzyme, tyrosine hydroxylase (TH). Catecholamines 76-89 tyrosine hydroxylase Rattus norvegicus 194-214 2858582-1 1985 Chronic hypotension and hypoglycemia are known to increase the capacity for catecholamine biosynthesis in the rat adrenal medulla by increasing the maximal velocity of the rate-limiting enzyme, tyrosine hydroxylase (TH). Catecholamines 76-89 tyrosine hydroxylase Rattus norvegicus 216-218 2858582-3 1985 These short-term alterations in adrenal TH activity are related to the severity of the stress, associated with parallel changes in catecholamine biosynthesis, and prevented by prior adrenal denervation. Catecholamines 131-144 tyrosine hydroxylase Rattus norvegicus 40-42 2986091-3 1985 The corticotropin-releasing factor is the predominant component of a complex control system of adrenal cortex secretion, which also includes catecholamines and the antidiuretic hormone. Catecholamines 141-155 corticotropin releasing hormone Homo sapiens 4-34 3985958-1 1985 Using electrochemical detection, 3-deazaadenosine, a proximal inhibitor of methylation via the inhibition of S-adenosylhomocysteine hydrolase, perturbed the metabolism of catecholamines in the adrenals of rats. Catecholamines 171-185 adenosylhomocysteinase Rattus norvegicus 109-141 2858497-6 1985 In this study the location of catecholamine-synthesizing enzymes was examined in the serial sections of the caudal medulla oblongata of the rat: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 30-43 dopamine beta-hydroxylase Rattus norvegicus 199-202 2858497-6 1985 In this study the location of catecholamine-synthesizing enzymes was examined in the serial sections of the caudal medulla oblongata of the rat: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 30-43 phenylethanolamine-N-methyltransferase Rattus norvegicus 209-248 2858497-6 1985 In this study the location of catecholamine-synthesizing enzymes was examined in the serial sections of the caudal medulla oblongata of the rat: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyl transferase (PNMT). Catecholamines 30-43 phenylethanolamine-N-methyltransferase Rattus norvegicus 250-254 2982644-1 1985 The effect of mycotoxin (T-2 toxin) on catecholamines and Na+, K+-ATPase activities in rat epididymis has been evaluated. Catecholamines 39-53 brachyury 2 Rattus norvegicus 25-28 4038484-7 1985 The decrease in hepatic PRL binding is not mediated by a hormone secreted by the adrenals, ovaries, or pituitary, or by catecholamines, but could be mediated by another plasma factor or by peripheral dopaminergic neurons. Catecholamines 120-134 prolactin Rattus norvegicus 24-27 3973595-5 1985 These observations strongly suggest that the soluble form of COMT from human brain catalyzes the O-methylation of catecholamines via an ordered reaction mechanism in which SAM is the leading substrate. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 61-65 3973595-6 1985 Since the membrane-bound form of COMT catalyzes the O-methylation of catecholamines through an identical reaction mechanism, these data provide further evidence that two forms of COMT, while being localized in distinct subcellular compartments, are quite similar in their molecular structure. Catecholamines 69-83 catechol-O-methyltransferase Homo sapiens 33-37 3973595-6 1985 Since the membrane-bound form of COMT catalyzes the O-methylation of catecholamines through an identical reaction mechanism, these data provide further evidence that two forms of COMT, while being localized in distinct subcellular compartments, are quite similar in their molecular structure. Catecholamines 69-83 catechol-O-methyltransferase Homo sapiens 179-183 3838726-8 1985 AHR 10718 significantly decreased normal automaticity, catecholamine-enhanced automaticity, and abnormal automaticity induced by barium or myocardial infarction. Catecholamines 55-68 aryl hydrocarbon receptor Canis lupus familiaris 0-3 2862024-0 1985 Effects of bombesin and gastrin releasing peptide on catecholamine secretion from rat adrenal gland, in vitro. Catecholamines 53-66 gastrin releasing peptide Rattus norvegicus 24-49 2862024-1 1985 The effects of bombesin and gastrin releasing peptide (GRP) on the release of catecholamine were investigated by using isolated rat adrenal gland. Catecholamines 78-91 gastrin releasing peptide Rattus norvegicus 28-53 2862024-1 1985 The effects of bombesin and gastrin releasing peptide (GRP) on the release of catecholamine were investigated by using isolated rat adrenal gland. Catecholamines 78-91 gastrin releasing peptide Rattus norvegicus 55-58 2862024-8 1985 These data strongly suggest that bombesin or GRP plays a physiological role as one of the important regulators in catecholamine secretion in the adrenal gland. Catecholamines 114-127 gastrin releasing peptide Rattus norvegicus 45-48 3156585-5 1985 These findings provide evidence that phosphorylation of TnI, C-protein and phospholamban in the intact cell is associated with functional alterations of the myofibrils and SR which may be responsible in part for the effects of catecholamines on the mammalian myocardium. Catecholamines 227-241 troponin I, fast skeletal muscle Oryctolagus cuniculus 56-59 3884075-3 1985 Before these treatments CS2 exposed rats had more dopamine and less adrenaline in their adrenals than controls, and CS2 exposure also elevated the adrenal synthesis of catecholamines. Catecholamines 168-182 calsyntenin 2 Rattus norvegicus 116-119 3884075-10 1985 It is concluded that the elevation of adrenal dopamine content and catecholamine synthesis in CS2 exposed rats satisfy part of the demand placed on the adrenal medulla by hypothermia and hypoglycaemia. Catecholamines 67-80 calsyntenin 2 Rattus norvegicus 94-97 3884075-12 1985 Moreover, when CS2 exposed rats were subjected to cold stress without immobilization their catecholamine synthesis was higher than the level measured in control rats after cold exposure. Catecholamines 91-104 calsyntenin 2 Rattus norvegicus 15-18 2860247-0 1985 Photoaffinity labelling of MSH receptors on Anolis melanophores: effects of catecholamines, calcium and forskolin. Catecholamines 76-90 proopiomelanocortin Homo sapiens 27-30 3921593-2 1985 Inhibition of endogenous catecholamine reuptake by nomifensine was able to significantly reduce PRL levels in normal subjects and in patients with liver cirrhosis, whereas only one out of 8 patients with hepatic encephalopathy showed a reduction in PRL levels. Catecholamines 25-38 prolactin Homo sapiens 96-99 3921593-2 1985 Inhibition of endogenous catecholamine reuptake by nomifensine was able to significantly reduce PRL levels in normal subjects and in patients with liver cirrhosis, whereas only one out of 8 patients with hepatic encephalopathy showed a reduction in PRL levels. Catecholamines 25-38 prolactin Homo sapiens 249-252 2981284-1 1985 To examine the role of cyclic AMP in the process of catecholamine release experiments have been performed with cultures of PC12 pheochromocytoma cells. Catecholamines 52-65 transmembrane serine protease 5 Rattus norvegicus 30-33 3157870-4 1985 The prolonged absence of Na+, Ca2+ or K+ from the perfusion or incubation medium caused a marked inhibition of uptake2 of catecholamines. Catecholamines 122-136 carbonic anhydrase 2 Rattus norvegicus 30-33 2417591-0 1985 Relation of substance P to catecholamine metabolism and stress. Catecholamines 27-40 tachykinin precursor 1 Homo sapiens 12-23 2417591-2 1985 In particular, it presents results on the function of SP in sympathetic ganglia (including the adrenal medulla) and discusses interconnections between the influence of SP on the catecholamine system and the role of SP both in the nervous and the circulatory system. Catecholamines 178-191 tachykinin precursor 1 Homo sapiens 168-170 2417591-2 1985 In particular, it presents results on the function of SP in sympathetic ganglia (including the adrenal medulla) and discusses interconnections between the influence of SP on the catecholamine system and the role of SP both in the nervous and the circulatory system. Catecholamines 178-191 tachykinin precursor 1 Homo sapiens 168-170 2411409-12 1985 In conclusion, neuropeptide Y-like immunoreactivity in the heart and great vessels coexists with that for catecholamines and is likely to originate from sympathetic ganglia. Catecholamines 106-120 pro-neuropeptide Y Cavia porcellus 15-29 3880425-1 1985 Catecholamines are potent noncompetitive inhibitors of dihydropteridine reductase in rat striatal synaptosomal preparations or purified from human liver. Catecholamines 0-14 quinoid dihydropteridine reductase Rattus norvegicus 55-81 3978417-6 1985 It is suggested that DMK-cut decreases the activity of the catecholaminergic system originating in A1 and terminating in PVN, where it causes catecholamine accumulation and may be involved in vasopressin release and thereby contribute to hypertension. Catecholamines 59-72 arginine vasopressin Rattus norvegicus 192-203 2981535-1 1985 When perfused cortex-free ox adrenal medulla was stimulated to secrete catecholamine by infusion of 0.1 mM acetylcholine for 4 min, the oxygen consumption increased to a value which was 0.15 +/- 0.07 mumole O2/min/g wet weight (+/- S.D., N = 12) above the pre-stimulation value of 0.49 +/- 0.15 (P less than 0.001). Catecholamines 71-84 immunoglobulin kappa variable 1D-39 Homo sapiens 207-213 4020712-3 1985 The cold activation of sympathico-adrenomedullary axis and the inhibition of CT response to cold after beta-antagonist treatment might suggest that endogenous catecholamines can enhance CT secretion in young rats. Catecholamines 159-173 calcitonin-related polypeptide alpha Rattus norvegicus 77-79 2860247-1 1985 Photoaffinity labelling of MSH receptors on Anolis melanophores was used as a tool for studying the effects of catecholamines, calcium and forskolin on hormone-receptor interaction and receptor-adenylate cyclase coupling. Catecholamines 111-125 proopiomelanocortin Homo sapiens 27-30 4020712-3 1985 The cold activation of sympathico-adrenomedullary axis and the inhibition of CT response to cold after beta-antagonist treatment might suggest that endogenous catecholamines can enhance CT secretion in young rats. Catecholamines 159-173 calcitonin-related polypeptide alpha Rattus norvegicus 186-188 2860247-2 1985 Covalent attachment of photoreactive alpha-MSH to its receptor was suppressed in calcium-free buffer but was hardly influenced by catecholamines or forskolin. Catecholamines 130-144 proopiomelanocortin Homo sapiens 43-46 2860247-4 1985 The suppression of pigment dispersion by catecholamines was blocked by the simultaneous presence of yohimbine but not prazosin, indicating that the catecholamines antagonize the alpha-MSH signal by inhibitory action on the adenylate cyclase system through an alpha-2 receptor. Catecholamines 41-55 proopiomelanocortin Homo sapiens 178-187 2860247-4 1985 The suppression of pigment dispersion by catecholamines was blocked by the simultaneous presence of yohimbine but not prazosin, indicating that the catecholamines antagonize the alpha-MSH signal by inhibitory action on the adenylate cyclase system through an alpha-2 receptor. Catecholamines 148-162 proopiomelanocortin Homo sapiens 178-187 3156386-0 1985 Androgens and effects of opioids and catecholamines on the smooth muscle of the rat vas deferens. Catecholamines 37-51 arginine vasopressin Rattus norvegicus 84-87 3974883-0 1985 Microinjection of calmodulin antibodies into cultured chromaffin cells blocks catecholamine release in response to stimulation. Catecholamines 78-91 calmodulin 1 Rattus norvegicus 18-28 3974883-7 1985 The delivery of intact antibodies raised against calmodulin directly into the cytoplasm of cultured chromaffin cells by erythrocyte ghost-mediated microinjection, inhibited catecholamine output in response to stimulation by either acetylcholine (10(-4) M) or a depolarizing concentration of potassium (56 mM). Catecholamines 173-186 calmodulin 1 Rattus norvegicus 49-59 6149822-9 1984 These data suggest that digitalis agents can interact with sites in the central nervous system to induce a release of renin from the kidney; this release appears to involve activation of beta-adrenergic receptors by catecholamines from the adrenal medulla, perhaps through a direct adrenal-kidney vascular network. Catecholamines 216-230 renin Rattus norvegicus 118-123 6531764-0 1984 The effects of catecholamines on circulating levels of antithrombin III in the rat. Catecholamines 15-29 serpin family C member 1 Rattus norvegicus 55-71 6507611-7 1984 ADN decreased levels of each catecholamine by 18-26%. Catecholamines 29-42 complement factor D Rattus norvegicus 0-3 6389230-7 1984 Thus, early morning increases in plasma glucose concentrations and insulin requirements observed in IDDM and NIDDM may be an exaggeration of a physiologic circadian variation in hepatic insulin sensitivity induced by antecedent changes in catecholamine and/or growth hormone secretion. Catecholamines 239-252 insulin Homo sapiens 67-74 2867555-1 1985 We found that the catecholamine biosynthetic enzymes, tyrosine hydroxylase, dopamine B-hydroxylase and phenylethanolamine N-methyltransferase share similar protein domains in their primary structures, and therefore are coded for by a single gene or a family of genes. Catecholamines 18-31 tyrosine hydroxylase Homo sapiens 54-74 2867555-1 1985 We found that the catecholamine biosynthetic enzymes, tyrosine hydroxylase, dopamine B-hydroxylase and phenylethanolamine N-methyltransferase share similar protein domains in their primary structures, and therefore are coded for by a single gene or a family of genes. Catecholamines 18-31 phenylethanolamine N-methyltransferase Homo sapiens 103-141 6532516-9 1984 Cholinesterase histochemistry in alternate sections revealed staining of motoneurons and their dendrites, and confirmed the location of the catecholamine varicosities within the motoneuron dendrite bundles. Catecholamines 140-153 butyrylcholinesterase Rattus norvegicus 0-14 6398261-2 1984 When the insulin dose delivered is adjusted to achieve a near match of the peripheral plasma glucose profile, the 24 h profiles of free fatty acids, glycerol, lactate and beta-hydroxybutyrate and the hormones, insulin, glucagon, cortisol and catecholamines were identical. Catecholamines 242-256 insulin Homo sapiens 9-16 6149959-1 1984 Tyrosine 3-monooxygenase (EC 1.14.16.2) and tryptophan 5-monooxygenase (EC 1.14.16.4) are generally believed to be the rate-limiting enzymes in the biosynthesis of the neurotransmitters, catecholamines and serotonin, respectively, and therefore the regulation of their activities is of particular importance. Catecholamines 187-201 tyrosine hydroxylase Rattus norvegicus 0-24 6386840-0 1984 Responses of catecholamines and other counterregulatory hormones to insulin-induced hypoglycemia in totally pancreatectomized patients. Catecholamines 13-27 insulin Homo sapiens 68-75 6599663-1 1984 Chromogranin A, the major soluble protein costored and coreleased by exocytosis with catecholamines, has been purified to homogeneity from both bovine adrenomedullary and human phaeochromocytoma chromaffin granules. Catecholamines 85-99 chromogranin A Bos taurus 0-14 6527741-9 1984 The opposite effects of vasopressin and oxytocin on catecholamine metabolism could be related to the opposite effects of the two peptides on behaviour, neuroendocrine and autonomic regulation. Catecholamines 52-65 arginine vasopressin Rattus norvegicus 24-35 6515125-0 1984 Inhibitors of phenylethanolamine-N-methyltransferase: effects on brain catecholamine content and blood pressure in DOCA-salt hypertensive rats. Catecholamines 71-84 phenylethanolamine-N-methyltransferase Rattus norvegicus 14-52 6398252-7 1984 This, coupled with the brisk output of catecholamines, may have prevented the heightened sensitivity to insulin anticipated because of their hypoglucagonemia. Catecholamines 39-53 insulin Homo sapiens 104-111 6084778-3 1984 Catecholamines stimulated adenylate cyclase activity in the following order of potency: (-)-isoprenaline greater than (-)-adrenaline = (-)-noradrenaline greater than phenylephrine, indicating that, in human right atrium, beta 1-adrenoceptors predominate. Catecholamines 0-14 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 221-227 6084908-5 1984 Neurotensin: Binding sites for NT in the substantia nigra and the ventral tegmentum of the rat were decreased after stereotaxic injection of the neurotoxin 6-hydroxydopamine, which specifically destroys catecholamine-containing neurons. Catecholamines 203-216 neurotensin Rattus norvegicus 0-11 6092358-1 1984 Evidence for catecholamine activation of alpha-ketoglutarate dehydrogenase. Catecholamines 13-26 oxoglutarate dehydrogenase Rattus norvegicus 41-74 6092358-14 1984 The results suggest that alpha-ketoglutarate dehydrogenase is a site of catecholamine action in rat liver. Catecholamines 72-85 oxoglutarate dehydrogenase Rattus norvegicus 25-58 6092358-15 1984 Since purified alpha-ketoglutarate dehydrogenase is known to be Ca2+ stimulated and Ca2+ flux is involved in catecholamine action, these findings also suggest that mitochondrial Ca2+ is elevated by catecholamines. Catecholamines 109-122 oxoglutarate dehydrogenase Rattus norvegicus 15-48 6092358-15 1984 Since purified alpha-ketoglutarate dehydrogenase is known to be Ca2+ stimulated and Ca2+ flux is involved in catecholamine action, these findings also suggest that mitochondrial Ca2+ is elevated by catecholamines. Catecholamines 198-212 oxoglutarate dehydrogenase Rattus norvegicus 15-48 6391758-7 1984 The alterations in endocrine function, which accompany weight gain, may contribute to an increase in blood pressure and there appears to be a relationship between plasma insulin and catecholamine concentrations, fat cell size and the development of hypertension. Catecholamines 182-195 insulin Homo sapiens 170-177 6092538-4 1984 Propranolol, a beta-adrenergic blocker, could block the increase of S-100 protein release by catecholamines, indicating that the release was mediated by the beta-adrenergic effect of catecholamines. Catecholamines 93-107 S100 calcium binding protein A1 Homo sapiens 68-73 6092538-4 1984 Propranolol, a beta-adrenergic blocker, could block the increase of S-100 protein release by catecholamines, indicating that the release was mediated by the beta-adrenergic effect of catecholamines. Catecholamines 183-197 S100 calcium binding protein A1 Homo sapiens 68-73 6147273-3 1984 Associated with the light-evoked increase of DA biosynthesis is a rapid activation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 141-154 tyrosine hydroxylase Rattus norvegicus 86-106 6151727-0 1984 [Effect of beta 1-partial agonist(ICI 118-587) on plasma catecholamines level and hemodynamics during exercise in congestive heart failure]. Catecholamines 57-71 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 11-17 6543178-0 1984 Impact of neonatal catecholamine treatment on adult response to vasopressin and norepinephrine. Catecholamines 19-32 arginine vasopressin Homo sapiens 64-75 6543178-1 1984 The present experiments have shown that neonatal imprinting with certain catecholamines had a significant impact on adult vascular adrenergic response, and on adult response to vasopressin as well. Catecholamines 73-87 arginine vasopressin Homo sapiens 177-188 6151589-3 1984 In catecholamine neurons, stained positively with the antisera to TH, specific immunoreactions were found in the LBs. Catecholamines 3-16 tyrosine hydroxylase Homo sapiens 66-68 6151589-7 1984 In catecholamine neurons in which LBs frequently occurred, TH enzyme protein might play an important part in the productions of LBs. Catecholamines 3-16 tyrosine hydroxylase Homo sapiens 59-61 6099973-0 1984 Responsiveness of the rat vas deferens to catecholamines and electrical stimulation during an infection with Trypanosoma brucei. Catecholamines 42-56 arginine vasopressin Rattus norvegicus 26-29 6441894-4 1984 In addition, the responses induced by injection of CCK into the hypothalamus were completely abolished by selective depletion of catecholamines in the hypothalamus (eg. Catecholamines 129-143 cholecystokinin Rattus norvegicus 51-54 6472366-1 1984 Chromogranin A is the major soluble protein stored and secreted by exocytosis, along with catecholamines, from vesicles in the adrenal medulla and sympathetic nerves. Catecholamines 90-104 chromogranin A Homo sapiens 0-14 6547992-3 1984 In view of the evidence that neuropeptide Y may coexist with adrenergic neurotransmitters, these findings suggest that it may play a role in regulation of LH release in the rat, either independently or in concert with catecholamines. Catecholamines 218-232 pyroglutamylated RFamide peptide Rattus norvegicus 29-41 6498634-6 1984 Activities of the catecholamine-degrading enzyme monoamine oxidase (MAO) and the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) served to monitor chronic alterations of catecholamine turnover in myocardium. Catecholamines 18-31 monoamine oxidase A Rattus norvegicus 68-71 6498634-6 1984 Activities of the catecholamine-degrading enzyme monoamine oxidase (MAO) and the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) served to monitor chronic alterations of catecholamine turnover in myocardium. Catecholamines 199-212 phenylethanolamine-N-methyltransferase Rattus norvegicus 112-150 6498634-6 1984 Activities of the catecholamine-degrading enzyme monoamine oxidase (MAO) and the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) served to monitor chronic alterations of catecholamine turnover in myocardium. Catecholamines 199-212 phenylethanolamine-N-methyltransferase Rattus norvegicus 152-156 6468668-3 1984 Nighttime increases in NAT activity are suppressed by light, protein synthesis inhibitors, and catecholamines. Catecholamines 95-109 bromodomain containing 2 Homo sapiens 23-26 6589361-1 1984 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenol and catechol drugs. Catecholamines 67-81 sulfotransferase family 1A member 1 Homo sapiens 0-23 6468668-5 1984 This suggests that catecholamines and cAMP are normally involved in the regulation of NAT. Catecholamines 19-33 bromodomain containing 2 Homo sapiens 86-89 6149999-2 1984 We have postulated that the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar genes. Catecholamines 28-41 dopamine beta-hydroxylase Homo sapiens 90-115 6149999-2 1984 We have postulated that the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar genes. Catecholamines 28-41 dopamine beta-hydroxylase Homo sapiens 117-120 6149999-2 1984 We have postulated that the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar genes. Catecholamines 28-41 phenylethanolamine N-methyltransferase Homo sapiens 127-165 6149999-2 1984 We have postulated that the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar genes. Catecholamines 28-41 phenylethanolamine N-methyltransferase Homo sapiens 167-171 6146657-1 1984 The systems responsible for phosphorylating tyrosine hydroxylase, the rate-limiting enzyme of catecholamine biosynthesis, were investigated in situ in adrenal medullary cells made permeable to solutes of up to 1,000 dalton by exposure to brief intense electric fields. Catecholamines 94-107 tyrosine hydroxylase Homo sapiens 44-64 6511455-0 1984 Mechanism of suppression of pressor vasopressin secretion by circulating catecholamines. Catecholamines 73-87 arginine vasopressin Homo sapiens 36-47 6589361-1 1984 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenol and catechol drugs. Catecholamines 67-81 sulfotransferase family 1A member 1 Homo sapiens 25-28 6088934-1 1984 Catecholamine administration elevates plasma cyclic AMP (cAMP) levels but the source of the cAMP is unknown. Catecholamines 0-13 cathelicidin antimicrobial peptide Canis lupus familiaris 57-61 6149987-12 1984 These results suggest that hyperuricemia induced by catecholamines is closely related to beta 2-adrenoceptor action. Catecholamines 52-66 adrenoceptor beta 2 Rattus norvegicus 89-108 6095374-7 1984 These results indicate that while the changes in food and water intake produced by the central injection of cholecystokinin, bombesin or gastrin may involve central catecholamine systems, those occurring after its systemic administration do not. Catecholamines 165-178 cholecystokinin Rattus norvegicus 108-123 6148714-1 1984 Immunocytochemistry with antibodies to catecholamine synthesizing enzymes has revealed cells in the retina of chick, mouse, hamster, rat, guinea-pig, piglet and marmoset which contain tyrosine hydroxylase but not dopamine beta-hydroxylase. Catecholamines 39-52 tyrosine 3-monooxygenase Callithrix jacchus 184-204 6095374-7 1984 These results indicate that while the changes in food and water intake produced by the central injection of cholecystokinin, bombesin or gastrin may involve central catecholamine systems, those occurring after its systemic administration do not. Catecholamines 165-178 gastrin Rattus norvegicus 137-144 6148714-1 1984 Immunocytochemistry with antibodies to catecholamine synthesizing enzymes has revealed cells in the retina of chick, mouse, hamster, rat, guinea-pig, piglet and marmoset which contain tyrosine hydroxylase but not dopamine beta-hydroxylase. Catecholamines 39-52 dopamine beta-hydroxylase Callithrix jacchus 213-238 6377920-3 1984 The key additional role of catecholamines in the development of stress hyperglycemia is interference with the normal feedback control of insulin and glucagon secretion by circulating glucose levels. Catecholamines 27-41 insulin Homo sapiens 137-144 6746636-9 1984 Since dihydropteridine reductase is required in vivo for the hydroxylation of tyrosine, the inhibition of this enzyme by apomorphine may represent one of several mechanisms by which apomorphine inhibits catecholamine synthesis. Catecholamines 203-216 quinoid dihydropteridine reductase Rattus norvegicus 6-32 6331191-9 1984 The spontaneous surge in catecholamine secretion at birth may be the key event because infusion of E or NE to fetal sheep in late gestation simulates the metabolic and hormonal profile of glucagon and insulin as well as glucose production that normally only occur with separation of the placenta. Catecholamines 25-38 LOC105613195 Ovis aries 201-208 6331454-6 1984 In conclusion, low amounts of glucose prevent catecholamine induced down-regulation of insulin receptor binding in human fat cells at physiological temperature. Catecholamines 46-59 insulin receptor Homo sapiens 87-103 6377920-5 1984 Thus, plasma insulin and glucagon levels during stress states will reflect the interaction between the opposing effects of hyperglycemia and catecholamines. Catecholamines 141-155 insulin Homo sapiens 13-20 6473080-6 1984 The relative effect of catecholamines on steady-state pHi was: adrenaline = isoproterenol greater than noradrenaline. Catecholamines 23-37 glucose-6-phosphate isomerase Rattus norvegicus 54-57 6547387-1 1984 Observations that a pancreatic polypeptide-like substance, possibly neuropeptide Y, is present in hypothalamic areas and may coexist with catecholamines prompted evaluation of its role in controlling feeding behavior. Catecholamines 138-152 neuropeptide Y Homo sapiens 68-82 6145760-2 1984 In this study, we have shown that NGF mediates the specific induction of the key enzymes in catecholamine biosynthesis, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 92-105 nerve growth factor Bos taurus 34-37 6145760-2 1984 In this study, we have shown that NGF mediates the specific induction of the key enzymes in catecholamine biosynthesis, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 92-105 phenylethanolamine N-methyltransferase Bos taurus 184-222 6145760-2 1984 In this study, we have shown that NGF mediates the specific induction of the key enzymes in catecholamine biosynthesis, tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 92-105 phenylethanolamine N-methyltransferase Bos taurus 224-228 6205025-1 1984 The immunocytochemical localizations of substance P, neurotensin, enkephalin and the catecholamine-synthesizing enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase were examined in the rat parabrachial region. Catecholamines 85-98 tyrosine hydroxylase Rattus norvegicus 120-140 6144326-1 1984 The beta-adrenergic receptor mediating the inhibition of sterol synthesis by catecholamines in freshly isolated human mononuclear leukocytes was defined pharmacologically by using selective beta 1- and beta 2-agonists and -antagonists. Catecholamines 77-91 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 190-208 6735152-0 1984 Catecholamine involvement in the control of growth hormone secretion in the domestic fowl. Catecholamines 0-13 growth hormone 1 Homo sapiens 44-58 6738812-0 1984 Involvement of catecholamines and glutamate in GABAergic mechanism regulatory to luteinizing hormone and prolactin secretion. Catecholamines 15-29 prolactin Rattus norvegicus 105-114 6738815-4 1984 These results, which are similar to those reported for centrally administered norepinephrine, raise the possibility that pancreatic polypeptide, or a similar peptide, may participate in the physiologic regulation of LH release, either independently or perhaps as a neuromodulator or a cotransmitter with catecholamines. Catecholamines 304-318 pancreatic polypeptide Rattus norvegicus 121-143 6145658-0 1984 Inhibitory influence of catecholamines on prolactin release in the turkey (Meleagris gallopavo). Catecholamines 24-38 prolactin Meleagris gallopavo 42-51 6145658-1 1984 The involvement of catecholamines (CAs) in the control of prolactin (PRL) secretion was investigated in female turkeys. Catecholamines 19-33 prolactin Meleagris gallopavo 58-67 6145658-1 1984 The involvement of catecholamines (CAs) in the control of prolactin (PRL) secretion was investigated in female turkeys. Catecholamines 19-33 prolactin Meleagris gallopavo 69-72 6145658-1 1984 The involvement of catecholamines (CAs) in the control of prolactin (PRL) secretion was investigated in female turkeys. Catecholamines 35-38 prolactin Meleagris gallopavo 58-67 6145658-1 1984 The involvement of catecholamines (CAs) in the control of prolactin (PRL) secretion was investigated in female turkeys. Catecholamines 35-38 prolactin Meleagris gallopavo 69-72 6145658-3 1984 Reduction in central CAs by alpha-MT or DDC, or blockade of adrenergic receptors by phentolamine resulted in elevated serum PRL levels in a dose-dependent manner. Catecholamines 21-24 prolactin Meleagris gallopavo 124-127 6147906-9 1984 These results suggested the following: 1) both glucagon and catecholamines may contribute to neurotensin-induced hyperglycemia, 2) neurotensin does not directly act on the liver, 3) catecholamine response could be mediated by baroceptor stimulation through hypotension, and 4) the hyperglycemic effect of anterior pituitary hormones does not participate in neurotensin-induced hyperglycemia. Catecholamines 60-74 neurotensin Canis lupus familiaris 93-104 6147906-9 1984 These results suggested the following: 1) both glucagon and catecholamines may contribute to neurotensin-induced hyperglycemia, 2) neurotensin does not directly act on the liver, 3) catecholamine response could be mediated by baroceptor stimulation through hypotension, and 4) the hyperglycemic effect of anterior pituitary hormones does not participate in neurotensin-induced hyperglycemia. Catecholamines 60-73 neurotensin Canis lupus familiaris 93-104 6145495-2 1984 Tyrosine hydroxylase (T-OH), the rate limiting enzyme in catecholamine biosynthesis was examined in the hypogastric (HG), coeliac (CG), and superior cervical ganglion (SCG) subsequent to castration. Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 0-20 6145495-2 1984 Tyrosine hydroxylase (T-OH), the rate limiting enzyme in catecholamine biosynthesis was examined in the hypogastric (HG), coeliac (CG), and superior cervical ganglion (SCG) subsequent to castration. Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 22-26 6144326-7 1984 In accordance with the influence of the agonists, the beta 2-antagonist butoxamine, but not the beta 1-antagonists atenolol, metoprolol and practolol, reversed the catecholamine action on sterol synthesis. Catecholamines 164-177 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 54-60 6144326-8 1984 The results provide evidence that catecholamines may regulate sterol synthesis by stimulating beta 2-adrenergic receptors. Catecholamines 34-48 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 94-100 6712976-0 1984 pH-dependent modulation of phospholipase A2 activity by alkaline cations and catecholamines in a granule-enriched fraction of adrenal medulla. Catecholamines 77-91 phospholipase A2 group IB Rattus norvegicus 27-43 6144276-7 1984 The results obtained here indicate that angiotensin II binding to neuron-enriched cultures is reciprocally related to the levels of neuronal catecholamines. Catecholamines 141-155 angiotensinogen Rattus norvegicus 40-54 6330618-3 1984 It is suggested, based on the present and previous findings that the anti-anaphylactic effect of TRH in the mouse is mediated through activation of beta 1-adrenoceptive effectors, secondary to central stimulation of sympathomedullary release of catecholamines. Catecholamines 245-259 thyrotropin releasing hormone Mus musculus 97-100 6326950-10 1984 Collectively, these results indicate that the beneficial effect of TRH in anaphylactic shock involves central nervous system actions which are mediated peripherally through interaction of sympatho-adrenomedullary catecholamines with beta-adrenoceptive effectors. Catecholamines 213-227 thyrotropin releasing hormone Mus musculus 67-70 6464779-0 1984 Catecholamine stimulation of copper dependent haemolysis: protective action of superoxide dismutase, catalase, hydroxyl radical scavengers and serum proteins (ceruloplasmin, albumin and apotransferrin). Catecholamines 0-13 ceruloplasmin Rattus norvegicus 159-172 6464779-3 1984 Superoxide dismutase, catalase and different hydroxyl radical scavengers (mannitol, tris, formate and ethanol) markedly reduced the haemolytic effect of copper and catecholamine, suggesting the possibility that superoxide radicals and hydrogen peroxide, formed in the reaction system, cooperate in producing hydroxyl radicals, which are directly involved in the haemolytic action. Catecholamines 164-177 catalase Rattus norvegicus 22-30 6464779-4 1984 The plasma proteins, ceruloplasmin, albumin and apotransferrin, also reduced the copper-catecholamine induced haemolysis. Catecholamines 88-101 ceruloplasmin Rattus norvegicus 21-34 6707633-5 1984 Concomitant with the Mg2+ accumulation, there is a significant loss of endogenous catecholamines. Catecholamines 82-96 mucin 7, secreted Homo sapiens 21-24 6707643-5 1984 The present results provide pharmacological evidence for a parallel release of catecholamines, AChE, and DBH from cultured adrenal chromaffin cells, and the stoichiometry of the release evoked by different secretagogues suggests that AChE and catecholamines are released from different cellular compartments. Catecholamines 79-93 acetylcholinesterase Bos taurus 234-238 6707643-5 1984 The present results provide pharmacological evidence for a parallel release of catecholamines, AChE, and DBH from cultured adrenal chromaffin cells, and the stoichiometry of the release evoked by different secretagogues suggests that AChE and catecholamines are released from different cellular compartments. Catecholamines 243-257 acetylcholinesterase Bos taurus 234-238 6715801-5 1984 These results suggest that an age-related increase in adrenal DBH activity may, at least in part, contribute to increased levels of circulating catecholamines. Catecholamines 144-158 dopamine beta-hydroxylase Rattus norvegicus 62-65 6715327-4 1984 Dopamine beta-hydroxylase involved in the biosynthesis of catecholamines was not present in neurosecretory vesicles, suggesting an alternative functional role for the cytochrome in these vesicles. Catecholamines 58-72 dopamine beta-hydroxylase Bos taurus 0-25 6145297-1 1984 The present study investigated the brain catecholamine metabolism of rats with liver injury induced either by malnutrition or with CCl4. Catecholamines 41-54 C-C motif chemokine ligand 4 Rattus norvegicus 131-135 6145128-2 1984 By means of catecholamine fluorescence histochemistry in combination with quantitative microfluorimetry the effects of luteinizing hormone-releasing hormone (LH-RH) has been studied on the amine levels and turnover in discrete catecholamine (CA) nerve terminal populations in the hypothalamus of the hypophysectomized male rat. Catecholamines 227-240 gonadotropin releasing hormone 1 Rattus norvegicus 119-156 6145128-2 1984 By means of catecholamine fluorescence histochemistry in combination with quantitative microfluorimetry the effects of luteinizing hormone-releasing hormone (LH-RH) has been studied on the amine levels and turnover in discrete catecholamine (CA) nerve terminal populations in the hypothalamus of the hypophysectomized male rat. Catecholamines 227-240 gonadotropin releasing hormone 1 Rattus norvegicus 158-163 6144370-6 1984 Tyrosine hydroxylase, the first enzyme of the catecholamine (CA) biosynthetic pathway, was found in the same cells which could be stained with PNMT antibodies as well as in the sympathetic ganglia. Catecholamines 46-59 tyrosine hydroxylase Gallus gallus 0-20 6144370-6 1984 Tyrosine hydroxylase, the first enzyme of the catecholamine (CA) biosynthetic pathway, was found in the same cells which could be stained with PNMT antibodies as well as in the sympathetic ganglia. Catecholamines 46-59 phenylethanolamine N-methyltransferase Gallus gallus 143-147 6142878-9 1984 Acute alpha 1-blockade with prazosin induces reflex elevation of catecholamines, which in the absence of blockade of hepatic beta 2-receptors produces elevation of plasma glucose. Catecholamines 65-79 adrenoceptor alpha 1D Homo sapiens 6-13 6371811-7 1984 Both C6-CM and NGF increased the catecholamine content of the cultures and reduced the relative content of epinephrine. Catecholamines 33-46 nerve growth factor Rattus norvegicus 5-18 6421820-0 1984 Chromogranin A, the major catecholamine storage vesicle soluble protein. Catecholamines 26-39 chromogranin A Bos taurus 0-14 6421820-6 1984 In brain, there was 1000-fold less CgA than in adrenal medulla, with a widespread regional distribution (maximal in neocortex) and an unusual subcellular distribution (maximal in cytosol), both of which differ from reported catecholamine distribution. Catecholamines 224-237 chromogranin A Bos taurus 35-38 6198467-3 1984 Substance P (10(-5) M) completely protected against desensitization of catecholamine release produced by acetylcholine at 37 degrees C or 23 degrees C and by nicotine at 23 degrees C; substance P also afforded appreciable protection against nicotine-induced desensitization at 37 degrees C. The peptide had no effect on K+-induced desensitization of catecholamine release. Catecholamines 350-363 tachykinin precursor 1 Homo sapiens 0-11 6198467-3 1984 Substance P (10(-5) M) completely protected against desensitization of catecholamine release produced by acetylcholine at 37 degrees C or 23 degrees C and by nicotine at 23 degrees C; substance P also afforded appreciable protection against nicotine-induced desensitization at 37 degrees C. The peptide had no effect on K+-induced desensitization of catecholamine release. Catecholamines 350-363 tachykinin precursor 1 Homo sapiens 184-195 6198467-6 1984 Substance P had little effect on subsequent catecholamine uptake, indicating that substance P"s protection against desensitization is a result of facilitation of catecholamine release rather than inhibition of catecholamine reuptake. Catecholamines 162-175 tachykinin precursor 1 Homo sapiens 82-93 6198467-6 1984 Substance P had little effect on subsequent catecholamine uptake, indicating that substance P"s protection against desensitization is a result of facilitation of catecholamine release rather than inhibition of catecholamine reuptake. Catecholamines 162-175 tachykinin precursor 1 Homo sapiens 82-93 6198467-8 1984 These in vitro studies suggest a similar role for substance P in vivo: substance P"s protection against nicotinic desensitization may ensure a maintained output of adrenal catecholamines during stress, when the splanchnic nerve releases large amounts of acetylcholine. Catecholamines 172-186 tachykinin precursor 1 Homo sapiens 71-82 6371583-4 1984 Aromatic L-amino acid decarboxylase was also present in serotonin neurons and the majority of catecholamine cell groups. Catecholamines 94-107 dopa decarboxylase Rattus norvegicus 0-35 6147817-6 1984 Thus catecholamines exert through an alpha 2 adrenoreceptor a negative control on basal and VIP-stimulated cyclic AMP formation in human colon. Catecholamines 5-19 vasoactive intestinal peptide Homo sapiens 92-95 6091217-5 1984 Elevated serum beta-endorphin concentrations induced by exercise have been linked to several psychological and physiological changes, including mood state changes and "exercise-induced euphoria", altered pain perception, menstrual disturbances in female athletes, and the stress responses of numerous hormones (growth hormone, ACTH, prolactin, catecholamines and cortisol). Catecholamines 344-358 proopiomelanocortin Homo sapiens 15-29 6145120-0 1984 The effect of somatostatin on striatal catecholamines. Catecholamines 39-53 somatostatin Rattus norvegicus 14-26 6365589-4 1984 When IAP-pretreated cells were exposed to a combination of insulin and isoprenaline, the catecholamine significantly reduced the stimulatory effect of insulin. Catecholamines 89-102 Cd47 molecule Rattus norvegicus 5-8 6366415-0 1984 Prolactin-releasing action of LRF: a central catecholamine mediated event? Catecholamines 45-58 CREB3 regulatory factor Homo sapiens 30-33 6366416-0 1984 Effect of trifluoperazine and calmodulin on catecholamine secretion by saponin-skinned cultured chromaffin cells. Catecholamines 44-57 calmodulin 1 Homo sapiens 30-40 6369182-1 1984 Regulation of the neurotensin (NT)-producing neurons by ascending catecholamine fibers in the paraventricular nucleus of the rat hypothalamus was examined using fluorescence histochemistry and immunohistochemistry after the destruction of the ascending catecholamine pathway by 6-hydroxydopamine. Catecholamines 66-79 neurotensin Rattus norvegicus 18-29 6141944-6 1984 These results suggest a physiological stimulatory effect of catecholamines on gastric acid secretion in man, through a beta 2 receptor coupled to the cyclic AMP system, regulated by somatostatin. Catecholamines 60-74 somatostatin Homo sapiens 182-194 6692984-9 1984 A sequential procedure for detecting catecholamine-containing cells histochemically followed by immunocytochemistry for somatostatin-like immunoreactivity showed that about 20% of the cells which contained catecholamines also contained somatostatin-like immunoreactivity. Catecholamines 206-220 somatostatin 1 Gallus gallus 120-132 6692984-10 1984 Greater than 90% of the somatostatin-containing cells in this analysis also contained catecholamines. Catecholamines 86-100 somatostatin 1 Gallus gallus 24-36 6325953-1 1984 In 10 healthy volunteers the effects of acute increases in concentrations of catecholamines in plasma induced by dynamic exercise (on a bicycle for 15 min at 80% of maximum heart rate) on lymphocyte beta 2-adrenoceptor density (determined by (+/-)-125iodocyanopindolol binding) and -responsiveness (determined by cyclic AMP responses to 10 mumol/l isoprenaline) were investigated. Catecholamines 77-91 adrenoceptor beta 2 Homo sapiens 199-218 6319050-1 1984 In the radioenzymatic assay of catecholamines, using catechol-O-methyltransferase, the yield of labelled product is frequently less than the expected value. Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 53-81 6362446-2 1984 Insulin hypoglycemia, a test hitherto widely used for the cephalic phase, is unsafe and nonspecific because it also stimulates catecholamine release which affects gastrin secretion. Catecholamines 127-140 gastrin Canis lupus familiaris 163-170 6324652-3 1984 When C-6 glioma cells are kept in culture in serum-containing medium, beta-adrenergic receptor density falls and, concomitantly, ability to accumulate cyclic adenosine monophosphate in response to stimulation with catecholamines declines. Catecholamines 214-228 complement C6 Rattus norvegicus 5-8 6378438-0 1984 Supine and standing plasma catecholamines in essential hypertensive patients with different renin levels. Catecholamines 27-41 renin Homo sapiens 92-97 6418525-7 1984 The effect of alpha MSH on LH release was blocked by pretreatment of the animals with alpha-methyl-paratyrosine, an inhibitor of catecholamine synthesis, as well as by pretreatment with an iv injection of spiroperidol, a dopamine receptor blocker. Catecholamines 129-142 proopiomelanocortin Rattus norvegicus 14-23 6100312-7 1984 The regional concentrations of amine metabolites in the CSF is in part a reflection of the concentration of catecholamines and indoleamines in the immediately adjacent neuronal parenchyma. Catecholamines 108-122 colony stimulating factor 2 Rattus norvegicus 56-59 6151991-2 1984 CRF, catecholamines and VIP stimulate ACTH release whereas glucocorticoids and SRIF block secretion. Catecholamines 5-19 pro-opiomelanocortin-alpha Mus musculus 38-42 20488102-1 1984 Neurotensin (NT)-catecholamine (CA) interactions have been characterized at the pre- and post synaptic level in the hypothalamus and the forebrain by a combined morphometrical, receptor autoradiographical, biochemical and quantitative microfluorimetrical analysis as well as by radioimmunoassay determinations of serum levels of adenohypophyseal hormones. Catecholamines 17-30 neurotensin Rattus norvegicus 0-11 6144144-7 1984 The maximum GH response did not vary over time to the repeated injections of hpGRF-44 in rats with lesions of the arcuate nucleus; however, interruption of catecholamine synthesis resulted in a significant decrease in the GH response to hpGRF-44 over time. Catecholamines 156-169 gonadotropin releasing hormone receptor Rattus norvegicus 222-224 6318757-5 1983 In addition, angiotensin II also inhibited the stimulation exerted by catecholamines. Catecholamines 70-84 angiotensinogen Rattus norvegicus 13-27 6314140-4 1983 The difference in responses to the two catecholamines was ascribed to the relative beta2-selectivity of epinephrine. Catecholamines 39-53 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 83-88 6630322-1 1983 The possible contribution of cerebrovascular monoamine oxidase (MAO) to the blood-brain barrier to catecholamines was studied in isolated porcine and rat microvessels by determining its activity with various substrates. Catecholamines 99-113 monoamine oxidase A Rattus norvegicus 45-62 6630322-1 1983 The possible contribution of cerebrovascular monoamine oxidase (MAO) to the blood-brain barrier to catecholamines was studied in isolated porcine and rat microvessels by determining its activity with various substrates. Catecholamines 99-113 monoamine oxidase A Rattus norvegicus 64-67 6630322-5 1983 These results show that this highly active form of MAO is unlikely to be saturated by physiological concentrations of catecholamine. Catecholamines 118-131 monoamine oxidase A Rattus norvegicus 51-54 6630322-6 1983 It can be estimated that, for a plasma concentration of NA of 1 microM, a facilitated diffusion accelerating the entry of the catecholamine into the cells by at least 15-fold would be necessary in order to exceed the catabolic capacity of MAO. Catecholamines 126-139 monoamine oxidase A Rattus norvegicus 239-242 6203633-4 1984 Substance P, somatostatin, and the enkephalins all produced an inhibition of the ACh-evoked secretion of catecholamines, but their potency ranged over 100-fold. Catecholamines 105-119 tachykinin precursor 1 Bos taurus 0-11 6203633-7 1984 Substance P had two distinct actions on the nicotinic response: (1) substance P inhibited acetylcholine-induced release of catecholamines; and (2) substance P protected against acetylcholine-induced desensitization of catecholamine release. Catecholamines 123-137 tachykinin precursor 1 Bos taurus 0-11 6203633-7 1984 Substance P had two distinct actions on the nicotinic response: (1) substance P inhibited acetylcholine-induced release of catecholamines; and (2) substance P protected against acetylcholine-induced desensitization of catecholamine release. Catecholamines 123-137 tachykinin precursor 1 Bos taurus 68-79 6203633-7 1984 Substance P had two distinct actions on the nicotinic response: (1) substance P inhibited acetylcholine-induced release of catecholamines; and (2) substance P protected against acetylcholine-induced desensitization of catecholamine release. Catecholamines 123-136 tachykinin precursor 1 Bos taurus 0-11 6203633-7 1984 Substance P had two distinct actions on the nicotinic response: (1) substance P inhibited acetylcholine-induced release of catecholamines; and (2) substance P protected against acetylcholine-induced desensitization of catecholamine release. Catecholamines 123-136 tachykinin precursor 1 Bos taurus 68-79 6203633-8 1984 With regard to (1), substance P inhibited the secretion of catecholamines and ATP evoked by acetylcholine or nicotine but not that evoked by K+ or veratridine, nor did substance P by itself affect secretion. Catecholamines 59-73 tachykinin precursor 1 Bos taurus 20-31 6203633-11 1984 With regard to (2), substance P (greater than 5 X 10(-6) M) completely protected against desensitization of catecholamine release produced by acetylcholine (greater than 10(-4) M) or nicotine (greater than 2.5 X 10(-6) M) with no effect on K+-induced desensitization. Catecholamines 108-121 tachykinin precursor 1 Bos taurus 20-31 6198467-1 1984 Substance P, a peptide endogenous to the splanchnic nerve, is known to inhibit the acetylcholine-and nicotine-induced release of catecholamines from isolated adrenal chromaffin cells. Catecholamines 129-143 tachykinin precursor 1 Homo sapiens 0-11 6198467-2 1984 In the present study the effect of substance P on desensitization of catecholamine release from these cells was examined. Catecholamines 69-82 tachykinin precursor 1 Homo sapiens 35-46 6198467-3 1984 Substance P (10(-5) M) completely protected against desensitization of catecholamine release produced by acetylcholine at 37 degrees C or 23 degrees C and by nicotine at 23 degrees C; substance P also afforded appreciable protection against nicotine-induced desensitization at 37 degrees C. The peptide had no effect on K+-induced desensitization of catecholamine release. Catecholamines 71-84 tachykinin precursor 1 Homo sapiens 0-11 6147817-1 1984 The actions of catecholamines on VIP-induced cyclic AMP is studied in human colon. Catecholamines 15-29 vasoactive intestinal peptide Homo sapiens 33-36 6324242-0 1984 Effects of catecholamine-related mammalian alkaloids on spontaneous and vasopressin-induced behavior in mice. Catecholamines 11-24 arginine vasopressin Homo sapiens 72-83 6702866-11 1984 Acute alpha 1-blockade with prazosin induces reflex elevation of catecholamine levels. Catecholamines 65-78 adrenoceptor alpha 1D Homo sapiens 6-13 6142006-1 1984 We tested the hypothesis that (1) beta 1-selective and nonselective beta adrenoceptor blockades have a different influence on stress-induced catecholamine overshoot, and (2) beta 1-selective blockade shifts the epinephrine/norepinephrine ratio in favor of norepinephrine. Catecholamines 141-154 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 34-40 6144080-0 1984 Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Catecholamines 77-91 neuropeptide Y Rattus norvegicus 45-48 6144080-1 1984 The distribution of neuropeptide Y immunoreactive cell bodies in relation to various types of catecholamine-containing cell bodies in the rat brain was analyzed immunohistochemically using antisera to tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. Catecholamines 94-107 neuropeptide Y Rattus norvegicus 20-34 6420400-11 1984 Secretion of catecholamines, induced by veratridine or nicotine, a cholinergic agonist, was suppressed when NaCl in the medium was replaced by isosmotic sucrose and unexpectedly low levels of dopamine beta-hydroxylase were observed in some cases. Catecholamines 13-27 dopamine beta-hydroxylase Bos taurus 192-217 6420703-8 1984 Using a specific antibody against rat liver NADPH-cytochrome P450 reductase in combination with immunohistochemical techniques, we have now localized this enzyme to define catecholamine (CA)-containing structures of the rat and monkey brain. Catecholamines 172-185 cytochrome p450 oxidoreductase Rattus norvegicus 44-75 6375223-5 1984 Angiotensin II was positively correlated with pulmonary wedge pressure, urea and catecholamines and negatively correlated with cardiac output and natremia. Catecholamines 81-95 angiotensinogen Homo sapiens 0-14 6152375-1 1984 We found that catecholamine biosynthetic enzymes, tyrosine hydroxylase, dopamine B-hydroxylase and phenylethanolamine N-methyl-transferase share similar protein domains in their primary structures, and therefore are coded for by a single gene or a family of genes. Catecholamines 14-27 tyrosine hydroxylase Homo sapiens 50-70 6711809-0 1984 Use of superoxide dismutase and catalase to protect catecholamines from oxidation in tissue culture studies. Catecholamines 52-66 catalase Mus musculus 32-40 6711809-3 1984 Addition of superoxide dismutase and catalase (10-25 micrograms/ml each) results in virtually complete inhibition of catecholamine oxidation under a variety of experimental conditions. Catecholamines 117-130 catalase Mus musculus 37-45 6711809-6 1984 Combined use of superoxide dismutase and catalase offers nonperturbing, long-lasting protection of catecholamines in studies with cells in vitro. Catecholamines 99-113 catalase Mus musculus 41-49 6327039-2 1984 In hypertensive patients, but not in normotensives, LVM index was significantly correlated with beta-adrenoceptor responsiveness, as evaluated by the chronotropic response to isoproterenol ( CD25 ) (r = 0.525, p less than 0.001) and with the 24-hour catecholamine urinary output (r = 0.485, p less than 0.001). Catecholamines 250-263 interleukin 2 receptor subunit alpha Homo sapiens 191-195 6327039-5 1984 No significant correlation was found between LVM or wall thickness and body surface area, age, blood pressure, heart rate, cardiac output, total peripheral resistance and left ventricular systolic wall stress, whereas CD25 was correlated with urinary catecholamines only in hypertensive patients (r = 0.606, p less than 0.001). Catecholamines 251-265 interleukin 2 receptor subunit alpha Homo sapiens 218-222 6141853-1 1984 We postulate that the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), dopamine B-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar gene coding sequence(s). Catecholamines 22-35 tyrosine hydroxylase Homo sapiens 57-77 6141853-1 1984 We postulate that the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), dopamine B-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar gene coding sequence(s). Catecholamines 22-35 dopamine beta-hydroxylase Homo sapiens 84-106 6141853-1 1984 We postulate that the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), dopamine B-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar gene coding sequence(s). Catecholamines 22-35 dopamine beta-hydroxylase Homo sapiens 108-111 6141853-1 1984 We postulate that the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), dopamine B-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar gene coding sequence(s). Catecholamines 22-35 phenylethanolamine N-methyltransferase Homo sapiens 117-155 6141853-1 1984 We postulate that the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), dopamine B-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) are coded for by similar gene coding sequence(s). Catecholamines 22-35 phenylethanolamine N-methyltransferase Homo sapiens 157-161 6141854-1 1984 The distribution of catecholamine neurons in the dorsal vagal complex is described on the basis of indirect immunofluorescence histochemistry using antisera to three enzymes in the catecholamine synthesis, tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine-N-methyltransferase, allowing differentiation between dopamine, noradrenaline and adrenaline cells. Catecholamines 20-33 dopamine beta-hydroxylase Homo sapiens 228-253 6141854-1 1984 The distribution of catecholamine neurons in the dorsal vagal complex is described on the basis of indirect immunofluorescence histochemistry using antisera to three enzymes in the catecholamine synthesis, tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine-N-methyltransferase, allowing differentiation between dopamine, noradrenaline and adrenaline cells. Catecholamines 20-33 phenylethanolamine N-methyltransferase Homo sapiens 258-296 6151422-2 1984 A subsequent challenge with the beta1-blocker atenolol caused a pressor response associated with diminished catecholamine release, impaired catecholamine clearance, loss of baroreflex response, and bradycardia. Catecholamines 108-121 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 32-37 6151422-2 1984 A subsequent challenge with the beta1-blocker atenolol caused a pressor response associated with diminished catecholamine release, impaired catecholamine clearance, loss of baroreflex response, and bradycardia. Catecholamines 140-153 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 32-37 6383859-0 1984 The effect of nerve growth factor (NGF) on the catecholamine contents of two human pheochromocytomas in tissue culture. Catecholamines 47-60 nerve growth factor Homo sapiens 14-33 6383859-0 1984 The effect of nerve growth factor (NGF) on the catecholamine contents of two human pheochromocytomas in tissue culture. Catecholamines 47-60 nerve growth factor Homo sapiens 35-38 6383859-7 1984 NGF treated cultures contained more catecholamine granula than the untreated cultures. Catecholamines 36-49 nerve growth factor Homo sapiens 0-3 6383859-8 1984 Though the number of catecholamine granula was increased by the NGF-treatment, the medium contained less catecholamines than in untreated cultures. Catecholamines 21-34 nerve growth factor Homo sapiens 64-67 6383859-8 1984 Though the number of catecholamine granula was increased by the NGF-treatment, the medium contained less catecholamines than in untreated cultures. Catecholamines 105-119 nerve growth factor Homo sapiens 64-67 6383859-9 1984 It may be concluded that NGF influences the liberation of adrenaline, noradrenaline and dopamine in tissue culture: though NGF treated cells contained more catecholamine granula, the catecholamines were retained in the pheochromocytoma cells. Catecholamines 156-169 nerve growth factor Homo sapiens 25-28 6383859-9 1984 It may be concluded that NGF influences the liberation of adrenaline, noradrenaline and dopamine in tissue culture: though NGF treated cells contained more catecholamine granula, the catecholamines were retained in the pheochromocytoma cells. Catecholamines 156-169 nerve growth factor Homo sapiens 123-126 6383859-9 1984 It may be concluded that NGF influences the liberation of adrenaline, noradrenaline and dopamine in tissue culture: though NGF treated cells contained more catecholamine granula, the catecholamines were retained in the pheochromocytoma cells. Catecholamines 183-197 nerve growth factor Homo sapiens 25-28 6693145-2 1984 Chromogranin A is the quantitatively major soluble protein in catecholamine storage vesicles of the adrenal medulla and sympathetic nerve, and has been a useful index of exocytosis during sympathoadrenal neurosecretion. Catecholamines 62-75 chromogranin A Homo sapiens 0-14 6358412-1 1984 The effect of catecholamines on the levels of S-100 protein and nervous system-specific enolase (NSE) in epididymal adipose tissue of Wistar rats in vivo was examined by sensitive enzyme immunoassay methods. Catecholamines 14-28 enolase 2 Rattus norvegicus 64-95 6358412-1 1984 The effect of catecholamines on the levels of S-100 protein and nervous system-specific enolase (NSE) in epididymal adipose tissue of Wistar rats in vivo was examined by sensitive enzyme immunoassay methods. Catecholamines 14-28 enolase 2 Rattus norvegicus 97-100 6358412-6 1984 These results suggest that the levels of S-100 protein and NSE in adipose tissue are regulated by catecholamines. Catecholamines 98-112 enolase 2 Rattus norvegicus 59-62 6324148-0 1984 The role of some central catecholamine systems in cholecystokinin-induced satiety. Catecholamines 25-38 cholecystokinin Rattus norvegicus 50-65 6146190-6 1984 Insulin, but not MSF, caused a marked increase in plasma catecholamine concentrations in DU patients whereas the acid responses were the same. Catecholamines 57-70 insulin Homo sapiens 0-7 6141843-3 1983 Tyrosine hydroxylase (T-OH) activity, the rate-limiting enzyme in catecholamine biosynthesis and a marker of noradrenergic maturation, was examined in the hypogastric (HG) and superior cervical ganglion (SCG). Catecholamines 66-79 tyrosine hydroxylase Rattus norvegicus 0-20 6141843-3 1983 Tyrosine hydroxylase (T-OH) activity, the rate-limiting enzyme in catecholamine biosynthesis and a marker of noradrenergic maturation, was examined in the hypogastric (HG) and superior cervical ganglion (SCG). Catecholamines 66-79 tyrosine hydroxylase Rattus norvegicus 22-26 6672070-2 1983 Concomitant with a large increase of plasma catecholamines, insulin concentration is reduced and blood glucose levels slowly increase. Catecholamines 44-58 insulin Homo sapiens 60-67 6139416-3 1983 Inhibitors of phospholipase A2 [rho-bromo-phenacylbromide (10 microM), trifluoperazine (3 microM), and quinacrine (3 microM) reduced the potassium-stimulated [3H]catecholamine release from synaptosomes to 78, 39, and 55%, respectively, of depolarized controls. Catecholamines 162-175 phospholipase A2 group IB Rattus norvegicus 14-30 6417272-3 1983 In the carotid body and the ganglion an inverse relationship exists between the catecholamine content and the DBH activity. Catecholamines 80-93 dopamine beta-hydroxylase Homo sapiens 110-113 6681179-8 1983 Renin release is, at least in part, controlled by circulating catecholamines. Catecholamines 62-76 renin Homo sapiens 0-5 6139754-5 1983 Furthermore, if nerve growth factor (NGF) is also added, the developing neurone-like cells exhibit immunoreactivity to tyrosine hydroxylase, a rate-limiting enzyme of catecholamine synthesis specific for adrenergic neurones. Catecholamines 167-180 nerve growth factor Homo sapiens 16-35 6098975-1 1983 Since catechol estrogens are potent competitive inhibitors of catechol-O-methyl transferase (COMT), it has been suggested that they may prolong the half-life of catecholamines which in turn can cause hypertension. Catecholamines 161-175 catechol-O-methyltransferase Rattus norvegicus 62-91 6098975-1 1983 Since catechol estrogens are potent competitive inhibitors of catechol-O-methyl transferase (COMT), it has been suggested that they may prolong the half-life of catecholamines which in turn can cause hypertension. Catecholamines 161-175 catechol-O-methyltransferase Rattus norvegicus 93-97 6139754-5 1983 Furthermore, if nerve growth factor (NGF) is also added, the developing neurone-like cells exhibit immunoreactivity to tyrosine hydroxylase, a rate-limiting enzyme of catecholamine synthesis specific for adrenergic neurones. Catecholamines 167-180 nerve growth factor Homo sapiens 37-40 6315436-8 1983 The hormone-sensitive lipase in permeabilized cells, as opposed to intact cells and homogenates, was activated by cyclic AMP to a degree that approached activation by catecholamines. Catecholamines 167-181 lipase G, endothelial type Rattus norvegicus 22-28 6311860-2 1983 In the present studies, we evaluated the effect of endogenous catecholamine stimulation (by treadmill exercise) on serum calcium (Ca) and immunoreactive PTH (iPTH) in six healthy volunteers. Catecholamines 62-75 parathyroid hormone Homo sapiens 153-156 6323066-13 1983 Catecholamines are probably intimately involved in the generation of GnRH pulses--which for noradrenaline poses a paradox as all noradrenergic cell bodies lie outside the MBH. Catecholamines 0-14 gonadotropin releasing hormone 1 Homo sapiens 69-73 6197373-4 1983 These results indicate that cultured vascular smooth muscle cells from SHR and SHRSP are more prone to increase the protein synthesis than those from WKY through the trophic induction of ODC activity and that the regulation of ODC activity by catecholamines is mediated through beta-agonistic effect in cultured smooth muscle cells. Catecholamines 243-257 ornithine decarboxylase 1 Rattus norvegicus 227-230 6141975-0 1983 Acute effects of beta 1 agonism with prenalterol on catecholamine circulating levels in patients with congestive heart failure. Catecholamines 52-65 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 17-23 6633161-1 1983 Chromogranin A is the major soluble protein co-stored and co-released with catecholamines from catecholamine storage vesicles of adrenal medulla and sympathetic nerve. Catecholamines 75-89 chromogranin A Bos taurus 0-14 6352725-1 1983 Chromogranin A, the major soluble protein costored and coreleased by exocytosis with catecholamines from the adrenal medulla, has recently been detected in several bovine polypeptide hormone producing tissues. Catecholamines 85-99 chromogranin A Bos taurus 0-14 6352725-3 1983 The chromogranin A antigen was purified from catecholamine storage vesicles of human pheochromocytoma, to which rabbit antisera were developed, allowing immunohistologic studies by the indirect rabbit anti-peroxidase technique. Catecholamines 45-58 chromogranin A Bos taurus 4-18 6314339-2 1983 The present study was designed to test the hypothesis that catecholamines can cause the release of ACTH in vivo by the direct stimulation of beta 2-adrenergic receptors in the rat anterior pituitary. Catecholamines 59-73 pro-opiomelanocortin-alpha Mus musculus 99-103 6314339-7 1983 These data indicate that beta 2-adrenergic receptors are present on anterior pituitary cells and suggest that catecholamines can directly stimulate ACTH secretion. Catecholamines 110-124 pro-opiomelanocortin-alpha Mus musculus 148-152 6416609-4 1983 The concentration of TRH was relatively high in the motor nuclei of the IIIrd, Vth, VIIth, Xth and XIIth cranial nerves, and less high in the area postrema, nucleus gracilis, locus coeruleus, lateral reticular nucleus (A1-catecholamine cell group), dorsal raphe and central gray matter. Catecholamines 222-235 thyrotropin releasing hormone Rattus norvegicus 21-24 6633161-1 1983 Chromogranin A is the major soluble protein co-stored and co-released with catecholamines from catecholamine storage vesicles of adrenal medulla and sympathetic nerve. Catecholamines 75-88 chromogranin A Bos taurus 0-14 6885962-4 1983 As plasma catecholamines levels returned to the normal range after extirpation of tumors, met-enkephalin-LI and leu-enkephalin-LI in plasma became undetectable in these patients. Catecholamines 10-24 proopiomelanocortin Homo sapiens 90-104 6360061-0 1983 Plasma catecholamine and cardiovascular responses to morphine and D-ala2-d-leu5-enkephalin in conscious rats. Catecholamines 7-20 proenkephalin Rattus norvegicus 80-90 6885962-7 1983 Plasma met-enkephalin-LI and leu-enkephalin-LI increased concomitantly with catecholamines after glucagon stimulation and during a spontaneous attack in a patient with pheochromocytoma. Catecholamines 76-90 proopiomelanocortin Homo sapiens 7-21 6885962-7 1983 Plasma met-enkephalin-LI and leu-enkephalin-LI increased concomitantly with catecholamines after glucagon stimulation and during a spontaneous attack in a patient with pheochromocytoma. Catecholamines 76-90 prodynorphin Homo sapiens 29-43 6885962-11 1983 It is concluded that met-enkephalin and leu-enkephalin are released concomitantly with catecholamines from pheochromocytomas. Catecholamines 87-101 proopiomelanocortin Homo sapiens 21-35 6352871-0 1983 Effects of ascorbic acid, dexamethasone, and insulin on the catecholamine and opioid peptide stores of cultured adrenal medullary chromaffin cells. Catecholamines 60-73 insulin Bos taurus 45-52 6885962-11 1983 It is concluded that met-enkephalin and leu-enkephalin are released concomitantly with catecholamines from pheochromocytomas. Catecholamines 87-101 prodynorphin Homo sapiens 40-54 6137552-2 1983 Pretreatment of these cells with catecholamines reduces the ability of (-)-isoproterenol to stimulate both cyclic AMP formation and ACTH secretion. Catecholamines 33-47 pro-opiomelanocortin-alpha Mus musculus 132-136 6355908-1 1983 A modification of the histofluorescent technique is described which allows for the enhanced visualization of catecholamine/indoleamine (CA/IN)-containing neurons and fibers in CNS and peripheral tissues. Catecholamines 109-122 calcineurin binding protein 1 Homo sapiens 136-141 6605176-4 1983 Present results support the notion of an inhibitory role of monoamines, particularly catecholamines, on the release of corticoliberin. Catecholamines 85-99 corticotropin releasing hormone Rattus norvegicus 119-133 6614194-7 1983 Adenosine deaminase in oxygenated atria potentiated the catecholamine-elicited contractile responses and reduced the progressive fall of the elevated contractile responses observed with continual catecholamine stimulation. Catecholamines 56-69 adenosine deaminase Rattus norvegicus 0-19 6614194-7 1983 Adenosine deaminase in oxygenated atria potentiated the catecholamine-elicited contractile responses and reduced the progressive fall of the elevated contractile responses observed with continual catecholamine stimulation. Catecholamines 196-209 adenosine deaminase Rattus norvegicus 0-19 6626992-8 1983 Catecholamine neurons in the substantia nigra, thought to contain MAO-A, did not show immune-specific staining. Catecholamines 0-13 monoamine oxidase A Rattus norvegicus 66-71 6614194-8 1983 In hypoxic atria adenosine deaminase potentiated the positive inotropic responses observed with catecholamine stimulation. Catecholamines 96-109 adenosine deaminase Rattus norvegicus 17-36 6136427-0 1983 Modulatory interactions between enkephalin and catecholamines: anatomical and physiological substrates. Catecholamines 47-61 proenkephalin Rattus norvegicus 32-42 6136427-1 1983 The anatomical and electrophysiological basis of enkephalin-catecholamine interactions was studied in the central nervous system of the Sprague-Dawley rat. Catecholamines 60-73 proenkephalin Rattus norvegicus 49-59 6358942-3 1983 alpha-Methyl-p-tyrosine, diethyldithiocarbamate and SKF 64139 inhibit catecholamine synthesis at the level of tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase, respectively. Catecholamines 70-83 dopamine beta-hydroxylase Rattus norvegicus 132-157 6358942-3 1983 alpha-Methyl-p-tyrosine, diethyldithiocarbamate and SKF 64139 inhibit catecholamine synthesis at the level of tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase, respectively. Catecholamines 70-83 phenylethanolamine-N-methyltransferase Rattus norvegicus 162-200 6658140-7 1983 The relationship between the renin-AII system and the central nervous system catecholamines could be involved in the control of development and maintenance of the renal arterial hypertension. Catecholamines 77-91 renin Rattus norvegicus 29-34 6658140-7 1983 The relationship between the renin-AII system and the central nervous system catecholamines could be involved in the control of development and maintenance of the renal arterial hypertension. Catecholamines 77-91 angiotensinogen Rattus norvegicus 35-38 6312241-7 1983 Aging, sex, diabetes mellitus, alcohol, catecholamines and trans fatty acids and saturated fats can all modulate the delta-6-desaturase enzyme which converts linoleic acid to gamma-linolenic acid. Catecholamines 40-54 fatty acid desaturase 2 Homo sapiens 117-135 6311185-2 1983 Challenging the cells with insulin alone had no effect on either the basal rate of pyruvate carboxylation or gluconeogenesis, although it did suppress the responses to both glucagon and catecholamines. Catecholamines 186-200 insulin Homo sapiens 27-34 6873459-10 1983 However, following exposure to exogenous catecholamine, fluorescent fibers were present in the sweat glands of mature rats and they corresponded in position and density to the plexus localized with acetylcholinesterase staining. Catecholamines 41-54 acetylcholinesterase Rattus norvegicus 198-218 6620178-6 1983 DBH was released together with catecholamine into the medium in which cells were suspended with these drugs. Catecholamines 31-44 dopamine beta-hydroxylase Cavia porcellus 0-3 6620178-14 1983 The results indicate that catecholamine secretion is accompanied with a simultaneous release of DBH and ATP from adrenal chromaffin cells. Catecholamines 26-39 dopamine beta-hydroxylase Cavia porcellus 96-99 6356168-5 1983 These results suggest that brain catecholamines, particularly dopamine, could play a role in the behavioral effects of LHRH. Catecholamines 33-47 gonadotropin releasing hormone 1 Rattus norvegicus 119-123 6224488-5 1983 The data therefore suggest that in the chromaffin cell stimulated to release catecholamines and proteins by exocytosis synexin first binds to membranes and then associates with itself to draw membranes together in preparation for fusion. Catecholamines 77-91 annexin A7 Homo sapiens 119-126 6870306-2 1983 In an attempt to enhance effects of cancer chemotherapy, Angiotensin II (AT), a vasoconstricting catecholamine, was applied to intra-arterial infusion of the drug for advanced breast cancer. Catecholamines 97-110 angiotensinogen Homo sapiens 57-71 6571355-4 1983 Thus, catecholamines may play an important role in the pathogenesis of diabetic retinopathy by stimulating the counterregulatory hormones, namely growth hormone and glucagon. Catecholamines 6-20 growth hormone 1 Homo sapiens 146-160 6409465-4 1983 It is likely that other counter-insulin hormones (growth hormone, catecholamines) also contribute to the pathogenesis of DKA, though their role is less well defined. Catecholamines 66-80 insulin Homo sapiens 32-39 6622754-1 1983 Chromogranin A is the major soluble protein, co-stored and co-released with catecholamines from storage vesicles of adrenal medulla and sympathetic nerve, and has been used as an index of exocytotic sympathoadrenal neurosecretion. Catecholamines 76-90 chromogranin A Homo sapiens 0-14 6136632-7 1983 The evidence for catecholestrogen action upon COMT, an outside membrane enzyme involved in the process of catecholamine degradation, supports the idea of a catechol action for 2-OHE2. Catecholamines 106-119 catechol-O-methyltransferase Rattus norvegicus 46-50 6305832-4 1983 After salt loading there was a significant reduction in plasma catecholamine concentrations with a significant relationship between changes in upright plasma epinephrine levels and changes in CD25 (r = 0.904, p less than 0.01) and in the slopes for delta HR/IS (r = 0.983, p less than 0.001) and delta cAMP/IS (r = 0.922, p less than 0.001). Catecholamines 63-76 interleukin 2 receptor subunit alpha Homo sapiens 192-196 6864216-1 1983 Vasoactive intestinal polypeptide (VIP) stimulates basal serotonin-N-acetyltransferase (NAT) activity in pineals in organ culture and enhances the effects of catecholamines in inducing the enzyme. Catecholamines 158-172 vasoactive intestinal peptide Homo sapiens 35-38 6356183-6 1983 Although alpha-MSH may stimulate the secretion of an adrenal steroid that blocks the facilitatory action of progesterone on female sexual behaviour the present results suggest that this inhibitory effect could be mediated by a catecholamine. Catecholamines 227-240 proopiomelanocortin Rattus norvegicus 9-18 6134722-1 1983 Incubation of intact rat adipocytes with physiological concentrations of catecholamines inhibits the specific binding of 125I-insulin and 125I-epidermal growth factor (EGF) by 40 to 70%. Catecholamines 73-87 epidermal growth factor Rattus norvegicus 138-166 6870900-0 1983 Inhibition of human brain dihydropteridine reductase [E.C.1.6.99.10] by the oxidation products of catecholamines, the aminochromes. Catecholamines 98-112 quinoid dihydropteridine reductase Homo sapiens 26-52 6350942-4 1983 These results, which suggest concomitant release of catecholamines and neuropeptides by the chromaffin cells, support the concept that VIP is involved in the stimulation of adrenal steroid secretion during stress conditions. Catecholamines 52-66 vasoactive intestinal peptide Homo sapiens 135-138 6134722-1 1983 Incubation of intact rat adipocytes with physiological concentrations of catecholamines inhibits the specific binding of 125I-insulin and 125I-epidermal growth factor (EGF) by 40 to 70%. Catecholamines 73-87 epidermal growth factor Rattus norvegicus 168-171 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-59 mucin 7, secreted Homo sapiens 108-111 6305955-11 1983 These experiments suggest that the proportions of the subunit forms of dopamine beta-hydroxylase can be regulated in cells by external signals and this may reflect alterations in post-translational processing enzymes and may serve as a potential mechanism to regulate catecholamine metabolism. Catecholamines 268-281 dopamine beta-hydroxylase Rattus norvegicus 71-96 6136012-1 1983 Using a specific antibody to the catecholamine (CA) synthesizing enzyme, tyrosine hydroxylase (TH), in combination with the avidin-biotin-peroxidase complex method, we have found evidence for the existence of a new CA-containing cell group extending from the orbitofrontal cortex through the olfactory and pyriform cortices in the brain of two species of monkey. Catecholamines 33-46 tyrosine hydroxylase Homo sapiens 73-93 6136012-1 1983 Using a specific antibody to the catecholamine (CA) synthesizing enzyme, tyrosine hydroxylase (TH), in combination with the avidin-biotin-peroxidase complex method, we have found evidence for the existence of a new CA-containing cell group extending from the orbitofrontal cortex through the olfactory and pyriform cortices in the brain of two species of monkey. Catecholamines 33-46 tyrosine hydroxylase Homo sapiens 95-97 6304039-1 1983 The adenylate cyclase-coupled beta 2-adrenergic receptor of the frog erythrocyte has served as a useful model system for elucidating the mechanisms of catecholamine-induced densensitization. Catecholamines 151-164 adrenoceptor beta 2 Homo sapiens 30-56 6304039-10 1983 The catecholamine-sensitive adenylate cyclase activity established in the vesicle-Xenopus hybrids showed the characteristic agonist potency series of the donor frog erythrocyte beta 2-adrenergic receptor. Catecholamines 4-17 adrenoceptor beta 2 Homo sapiens 177-203 6832567-1 1983 The relationship between serum catecholamines and serum gastrin in the basal state and in response to a liquid test meal was investigated in 6 patients with histologically proven pheochromocytoma before and after surgical removal of the tumor. Catecholamines 31-45 gastrin Homo sapiens 56-63 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-59 mucin 7, secreted Homo sapiens 160-163 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-59 mucin 7, secreted Homo sapiens 160-163 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-59 mucin 7, secreted Homo sapiens 160-163 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-58 mucin 7, secreted Homo sapiens 108-111 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-58 mucin 7, secreted Homo sapiens 160-163 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-58 mucin 7, secreted Homo sapiens 160-163 6348202-4 1983 These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. Catecholamines 45-58 mucin 7, secreted Homo sapiens 160-163 6348202-6 1983 A reduced serum Mg2+ concentration may enhance the action of catecholamines on the heart muscle as well as the action of vasopressive hormones, thus provoking contraction of coronary artery smooth muscle cells and favouring the development of arrhythmia. Catecholamines 61-75 mucin 7, secreted Homo sapiens 16-19 6611632-2 1983 The authors determined the dissociation constant, the constant of copper complex formation, the inhibitory action on the catecholamine biosynthesis enzyme dopamine beta-hydroxylase (DBH; copper glycoprotein), as well as the antihypertensive effect on spontaneously hypertensive rats of a series of substituted picolinic or fusaric acids (FA; 5-n-butylpicolinic acids). Catecholamines 121-134 dopamine beta-hydroxylase Rattus norvegicus 155-180 6865904-0 1983 Phospholipase A2 inhibitors block catecholamine secretion and calcium uptake in cultured bovine adrenal medullary cells. Catecholamines 34-47 LOC104974671 Bos taurus 0-16 6865904-2 1983 The possibility that it may be involved in exocytosis of catecholamine from primary dissociated cultures of bovine adrenal medullary cells was investigated by studying the effects on catecholamine secretion and 44Ca2+ uptake of three phospholipase A2 inhibitors: p-bromophenacyl bromide (BPB), Upjohn Compound 1002, and mepacrine. Catecholamines 57-70 LOC104974671 Bos taurus 234-250 6865904-10 1983 The data suggest that phospholipase A2 inhibitors block catecholamine secretion from intact chromaffin cells by blocking Ca2+ influx. Catecholamines 56-69 LOC104974671 Bos taurus 22-38 6343807-9 1983 These data demonstrate that endogenous kininases and catecholamines may dramatically affect the increase in protein efflux and edema formation produced by either local or systemic infusions of bradykinin by modulating the magnitude of the increase in macromolecular permeability. Catecholamines 53-67 kininogen 1 Canis lupus familiaris 193-203 6403791-2 1983 Protease inhibitors and calmodulin inhibitors inhibited catecholamine secretion induced by acetylcholine but did not inhibit the secretion induced by arachidonic acid. Catecholamines 56-69 calmodulin Bos taurus 24-34 6833287-6 1983 Soluble dopamine-beta-hydroxylase, a protein marker of granule contents, was released proportionally with catecholamine in a Ca2+ dependent manner. Catecholamines 106-119 dopamine beta-hydroxylase Bos taurus 8-33 6403791-4 1983 These results suggest that a protease and calmodulin are involved in the successive reaction after stimulus-receptor coupling and arachidonic acid or its metabolites might be important in catecholamine secretion from bovine adrenal medullary cells. Catecholamines 188-201 calmodulin Bos taurus 42-52 6346469-7 1983 Administration of insulin induced a more than two-fold increase in the two catecholamines both in the rabbit and the rat. Catecholamines 75-89 insulin Oryctolagus cuniculus 18-25 6847709-0 1983 Suppression by phospholipase A2 inhibitors of secretion of catecholamines from isolated adrenal medullary cells by suppression of cellular calcium uptake. Catecholamines 59-73 LOC104974671 Bos taurus 15-31 6847709-1 1983 The involvement of phospholipase A2 in the secretion of catecholamines and cellular uptake of 45Ca2+ was investigated in isolated bovine adrenal medullary cells. Catecholamines 56-70 LOC104974671 Bos taurus 19-35 6847709-3 1983 Phospholipase A2 inhibitors, such as quinacrine, chloroquine, quinine and p-bromophenacyl bromide, all inhibited the secretion of catecholamines evoked by carbamylcholine in a dose-dependent manner. Catecholamines 130-144 LOC104974671 Bos taurus 0-16 6847709-4 1983 These phospholipase A2 inhibitors also inhibited the cellular uptake of 45Ca2+ evoked by carbamylcholine with similar dose-response curves to those for inhibition of catecholamine secretion. Catecholamines 166-179 LOC104974671 Bos taurus 6-22 6847709-6 1983 Phospholipase A2 inhibitors seem to suppress the secretion of catecholamines by interfering with the linkage between acetylcholine receptors and Ca-channels by the membrane effects including the inhibition of endogenous phospholipase A2 activity of the adrenal medullary cells. Catecholamines 62-76 LOC104974671 Bos taurus 0-16 6847709-6 1983 Phospholipase A2 inhibitors seem to suppress the secretion of catecholamines by interfering with the linkage between acetylcholine receptors and Ca-channels by the membrane effects including the inhibition of endogenous phospholipase A2 activity of the adrenal medullary cells. Catecholamines 62-76 LOC104974671 Bos taurus 220-236 6350003-5 1983 A close correlation was found between urine catecholamines and plasma renin activity and between urine noradrenaline and aldosterone. Catecholamines 44-58 renin Homo sapiens 70-75 6572968-0 1983 Genes for catecholamine biosynthesis: cloning by expression and identification of the cDNA for rat dopamine beta-hydroxylase. Catecholamines 10-23 dopamine beta-hydroxylase Rattus norvegicus 99-124 6834109-7 1983 The finding that concomitant release of AChE and catecholamines occurs on exposure of the cells to nicotinic agonists suggests that released AChE may have a physiological role at neuroeffector junctions. Catecholamines 49-63 acetylcholinesterase Bos taurus 141-145 6135184-0 1983 Occurrence of neuropeptide Y (NPY)-like immunoreactivity in catecholamine neurons in the human medulla oblongata. Catecholamines 60-73 neuropeptide Y Homo sapiens 14-28 6135184-0 1983 Occurrence of neuropeptide Y (NPY)-like immunoreactivity in catecholamine neurons in the human medulla oblongata. Catecholamines 60-73 neuropeptide Y Homo sapiens 30-33 6191240-11 1983 The results also suggest that part of the refractoriness of nephrectomized rats to the hypotensive activity of NT could be due to the release of catecholamines from adrenal glands by NT. Catecholamines 145-159 neurotensin Rattus norvegicus 111-113 6191240-11 1983 The results also suggest that part of the refractoriness of nephrectomized rats to the hypotensive activity of NT could be due to the release of catecholamines from adrenal glands by NT. Catecholamines 145-159 neurotensin Rattus norvegicus 183-185 6299117-5 1983 Phentolamine, phenoxybenzamine, propranolol, catecholamine depletion of preparations by reserpine-tetrabenazine, and the block of catecholamine synthesis at different levels significantly inhibited CCK-OP-induced tonic contraction, whereas atropine had no influence. Catecholamines 130-143 cholecystokinin Rattus norvegicus 198-201 6337875-2 1983 When no hormones were present, N6-phenylisopropyladenosine had little or no effect; however, the nucleoside potentiated insulin inhibition of catecholamine-stimulated events, such as lipolysis, and, conversely, diminished or blocked catecholamine inhibition of insulin-stimulated processes, such as 2-deoxyglucose uptake, glucose oxidation and esterification, even under conditions where N6-phenylisopropyladenosine, alone, was ineffective in reversing catecholamine actions. Catecholamines 142-155 insulin Homo sapiens 120-127 6337875-2 1983 When no hormones were present, N6-phenylisopropyladenosine had little or no effect; however, the nucleoside potentiated insulin inhibition of catecholamine-stimulated events, such as lipolysis, and, conversely, diminished or blocked catecholamine inhibition of insulin-stimulated processes, such as 2-deoxyglucose uptake, glucose oxidation and esterification, even under conditions where N6-phenylisopropyladenosine, alone, was ineffective in reversing catecholamine actions. Catecholamines 233-246 insulin Homo sapiens 120-127 6337875-2 1983 When no hormones were present, N6-phenylisopropyladenosine had little or no effect; however, the nucleoside potentiated insulin inhibition of catecholamine-stimulated events, such as lipolysis, and, conversely, diminished or blocked catecholamine inhibition of insulin-stimulated processes, such as 2-deoxyglucose uptake, glucose oxidation and esterification, even under conditions where N6-phenylisopropyladenosine, alone, was ineffective in reversing catecholamine actions. Catecholamines 233-246 insulin Homo sapiens 120-127 6296187-6 1983 It is concluded that the stimulatory effect of catecholamines on PDE may be one reason for the failure of these agents to produce a sustained increase in the cAMP level and that the effect of insulin on PDE may be one mechanism by which insulin reduces the rate of lipolysis. Catecholamines 47-61 insulin Homo sapiens 237-244 6414988-0 1983 Effect of catecholamines on ornithine decarboxylase activity monitored in the perfused rat heart. Catecholamines 10-24 ornithine decarboxylase 1 Rattus norvegicus 28-51 6187227-5 1983 Moreover, interruption of the renin-angiotensin system blunted the anticipated rise in catecholamines and heart rate during the additional hypotension induced by converting enzyme blockade after hemorrhage. Catecholamines 87-101 renin Canis lupus familiaris 30-35 6603348-1 1983 The effect of bilateral adrenal medullectomy on the activity of catecholamine degrading enzymes--catechol-o-methyl transferase (COMT) and monoamino oxidase (MAO)--in adrenal cortex and on the level of corticosterone in plasma was studied in the rats subjected either to a single (2.5 h) or repeated (2.5 h daily for 150 days omitting Saturdays and Sundays) immobilization stress. Catecholamines 64-77 catechol-O-methyltransferase Rattus norvegicus 88-126 6603348-1 1983 The effect of bilateral adrenal medullectomy on the activity of catecholamine degrading enzymes--catechol-o-methyl transferase (COMT) and monoamino oxidase (MAO)--in adrenal cortex and on the level of corticosterone in plasma was studied in the rats subjected either to a single (2.5 h) or repeated (2.5 h daily for 150 days omitting Saturdays and Sundays) immobilization stress. Catecholamines 64-77 catechol-O-methyltransferase Rattus norvegicus 128-132 6603348-1 1983 The effect of bilateral adrenal medullectomy on the activity of catecholamine degrading enzymes--catechol-o-methyl transferase (COMT) and monoamino oxidase (MAO)--in adrenal cortex and on the level of corticosterone in plasma was studied in the rats subjected either to a single (2.5 h) or repeated (2.5 h daily for 150 days omitting Saturdays and Sundays) immobilization stress. Catecholamines 64-77 monoamine oxidase A Rattus norvegicus 157-160 6824696-0 1983 Inhibition of dihydropteridine reductase by catecholamines and related compounds. Catecholamines 44-58 quinoid dihydropteridine reductase Homo sapiens 14-40 6190104-0 1983 Localization of substance P- and enkephalin-like immunoreactivity in relation to catecholamine-containing cell bodies in the cat dorsolateral pontine tegmentum: an immunofluorescence study. Catecholamines 81-94 tachykinin precursor 1 Homo sapiens 16-27 6856953-2 1983 antagonized the inactivation of MAO by pargyline as measured by direct enzyme assays in brain homogenates and by accumulation of hypothalamic catecholamines. Catecholamines 142-156 monoamine oxidase A Rattus norvegicus 32-35 6130979-0 1983 Catecholamines inhibit insulin-stimulated glucose transport in adipocytes, in the presence of adenosine deaminase. Catecholamines 0-14 adenosine deaminase Rattus norvegicus 94-113 6298402-0 1983 Catecholamine-induced renin release in the anesthetized mongrel dog is due to both alpha and beta adrenoceptor stimulation: evidence that only the alpha adrenoceptor component is prostaglandin mediated. Catecholamines 0-13 renin Canis lupus familiaris 22-27 6406930-11 1983 The fact that both immunoreactive neurotensin and neurotensin receptors are found in high concentration in the ventral tegmental area supports the possible physiological significance of this peptide-catecholamine interaction. Catecholamines 199-212 neurotensin Rattus norvegicus 34-45 6406930-11 1983 The fact that both immunoreactive neurotensin and neurotensin receptors are found in high concentration in the ventral tegmental area supports the possible physiological significance of this peptide-catecholamine interaction. Catecholamines 199-212 neurotensin Rattus norvegicus 50-61 6134522-1 1983 In primary cultures of rat hepatocytes, epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and foetal-calf serum (FCS) prevented the stimulation of amino acid transport by glucagon (cyclic AMP-dependent) and by catecholamines (cyclic AMP-independent), but not by insulin. Catecholamines 229-243 epidermal growth factor like 1 Rattus norvegicus 40-63 6134522-1 1983 In primary cultures of rat hepatocytes, epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and foetal-calf serum (FCS) prevented the stimulation of amino acid transport by glucagon (cyclic AMP-dependent) and by catecholamines (cyclic AMP-independent), but not by insulin. Catecholamines 229-243 epidermal growth factor like 1 Rattus norvegicus 65-68 6130707-0 1983 Central injection of angiotensin II alters catecholamine activity in rat brain. Catecholamines 43-56 angiotensinogen Rattus norvegicus 21-35 6339003-0 1983 Effect of insulin on central catecholamines. Catecholamines 29-43 insulin Homo sapiens 10-17 6339003-1 1983 The effects of insulin on levels and turnover of catecholamines in the hypothalamus and medulla oblongata were investigated. Catecholamines 49-63 insulin Homo sapiens 15-22 6339003-4 1983 These results indicate that the effects of insulin on central catecholamines are elicited by its action in the brain. Catecholamines 62-76 insulin Homo sapiens 43-50 6130707-2 1983 The effect of ANG II injected intracerebroventricularly on catecholamine utilization in specific rat brain regions was examined. Catecholamines 59-72 angiotensinogen Rattus norvegicus 14-20 6346804-0 1983 Neuropeptide Y (NPY)- and FMRFamide neuropeptide-like immunoreactivities in catecholamine neurons of the rat medulla oblongata. Catecholamines 76-89 neuropeptide Y Rattus norvegicus 0-21 6854660-6 1983 We suggest that the apparent integrity of noradrenergic vesicle populations is consistent with reports by other investigators that levels of the catecholamine synthesizing enzyme, tyrosine hydroxylase, in sympathetic ganglia increase with age. Catecholamines 145-158 tyrosine hydroxylase Rattus norvegicus 180-200 6132028-6 1983 In the present study, the catecholamine-synthesizing enzyme, phenylethanolamine-N-methyltransferase (PNMT), and the neuropeptide, somatostatin, have been used as examples from the central nervous system of the rat, but the procedure is applicable to other antigens as well as other cell types and tissues. Catecholamines 26-39 phenylethanolamine-N-methyltransferase Rattus norvegicus 61-99 6132028-6 1983 In the present study, the catecholamine-synthesizing enzyme, phenylethanolamine-N-methyltransferase (PNMT), and the neuropeptide, somatostatin, have been used as examples from the central nervous system of the rat, but the procedure is applicable to other antigens as well as other cell types and tissues. Catecholamines 26-39 phenylethanolamine-N-methyltransferase Rattus norvegicus 101-105 6299446-6 1983 These results indicate that steroid-induced increases in the potency of catecholamines in pig bronchus can be explained in terms of inhibition of COMT or extraneuronal uptake or both. Catecholamines 72-86 catechol-O-methyltransferase Sus scrofa 146-150 6401799-8 1983 We conclude that the activity of tyrosine 3-monooxygenase in PC12 cells can be regulated by several distinct mechanisms; that glucocorticoids cause a coordinate increase in TH activity and in catecholamine storage; that steroids increase the storage of catecholamines in a releasable pool; and that the steroid-induced increase in catecholamine storage may result in increased secretion of catecholamines from steroid-treated cells. Catecholamines 192-205 tyrosine hydroxylase Rattus norvegicus 33-57 6401799-8 1983 We conclude that the activity of tyrosine 3-monooxygenase in PC12 cells can be regulated by several distinct mechanisms; that glucocorticoids cause a coordinate increase in TH activity and in catecholamine storage; that steroids increase the storage of catecholamines in a releasable pool; and that the steroid-induced increase in catecholamine storage may result in increased secretion of catecholamines from steroid-treated cells. Catecholamines 253-267 tyrosine hydroxylase Rattus norvegicus 33-57 6401799-8 1983 We conclude that the activity of tyrosine 3-monooxygenase in PC12 cells can be regulated by several distinct mechanisms; that glucocorticoids cause a coordinate increase in TH activity and in catecholamine storage; that steroids increase the storage of catecholamines in a releasable pool; and that the steroid-induced increase in catecholamine storage may result in increased secretion of catecholamines from steroid-treated cells. Catecholamines 253-266 tyrosine hydroxylase Rattus norvegicus 33-57 6401799-8 1983 We conclude that the activity of tyrosine 3-monooxygenase in PC12 cells can be regulated by several distinct mechanisms; that glucocorticoids cause a coordinate increase in TH activity and in catecholamine storage; that steroids increase the storage of catecholamines in a releasable pool; and that the steroid-induced increase in catecholamine storage may result in increased secretion of catecholamines from steroid-treated cells. Catecholamines 390-404 tyrosine hydroxylase Rattus norvegicus 33-57 6305147-1 1983 TRH may act on the brain independently of its effects on the pituitary, and some of the CNS actions of TRH are probably closely related to brain catecholamines. Catecholamines 145-159 thyrotropin releasing hormone Rattus norvegicus 103-106 6847818-5 1983 The finding of neurotensin-like immunoreactivity in noradrenaline-containing cells of the cat adrenal medulla provides further evidence in support of the postulated existence of heterogeneous subpopulations of noradrenaline-containing cells and suggests a possible functional interrelationship between neurotensin and catecholamine. Catecholamines 318-331 neurotensin Bos taurus 15-26 6304829-1 1983 The relationships among isometric tension development, the oxidation-reduction states of pyridine nucleotides and cytochrome c, and the oxygenation state of myoglobin have been assessed using the arterially perfused rabbit interventricular septum under different conditions of contraction rate, perfusate [Ca2+] and pH, catecholamine stress, and hypoxia. Catecholamines 320-333 LOW QUALITY PROTEIN: myoglobin Oryctolagus cuniculus 157-166 6641229-0 1983 The role of catecholamines in myoglobin content increase in the myocardium. Catecholamines 12-26 myoglobin Canis lupus familiaris 30-39 6641229-6 1983 The author advances the hypothesis that increased catecholamines secretion is one of the causes of the increase in myoglobin concentration in the heart muscle. Catecholamines 50-64 myoglobin Canis lupus familiaris 115-124 6339120-5 1983 Administration of fusaric acid, a dopamine-beta-hydroxylase inhibitor markedly decreased urinary excretion of catecholamine and prostaglandin E in both SHR and Wistar rat and abolished the development of hypertension in SHR. Catecholamines 110-123 dopamine beta-hydroxylase Rattus norvegicus 34-59 6138298-6 1983 Thus, the catecholamine response of the rabbit and human cornea is mainly mediated by beta 2-adrenergic receptors. Catecholamines 10-23 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 86-92 6293880-5 1983 These in vitro findings support the hypothesis that the inotropic response of the heart to catecholamine stimulation involves phosphorylation of TnI and phospholamban. Catecholamines 91-104 troponin I, fast skeletal muscle Oryctolagus cuniculus 145-148 6653697-6 1983 Measurements of catecholamine turnover rates in the MPO/AH and in the mediobasal hypothalamus (MBH) yielded reduced preoptic but unchanged hypothalamic norepinephrine (NE) and stimulated hypothalamic dopamine (DA) turnover. Catecholamines 16-29 myeloperoxidase Rattus norvegicus 52-55 6423471-0 1983 Effects of thyrotropin-releasing hormone on catecholamine concentration in various structures of the rat brain. Catecholamines 44-57 thyrotropin releasing hormone Rattus norvegicus 11-40 6341193-5 1983 In pheochromocytoma, high levels of plasma catecholamines contribute to a high renin state which may have pathophysiologic implications. Catecholamines 43-57 renin Homo sapiens 79-84 6642693-6 1983 During highly intensive dynamic exercise (test 1), three times higher catecholamine and 50% higher lactate responses were observed, than during peripheral-muscular limited endurance exercise (test 2). Catecholamines 70-83 serine protease 21 Homo sapiens 42-48 6188774-7 1983 Substance P (SP) modulates the secretion of catecholamines and ATP evoked by ACh or nicotine but not that evoked by K+ or veratridine. Catecholamines 44-58 tachykinin precursor 1 Bos taurus 0-11 24875600-7 1983 Thus, the ODC/polyamine system appears to play a critical postnatal role in catecholamine systems specifically undergoing active synaptogenesis. Catecholamines 76-89 ornithine decarboxylase 1 Rattus norvegicus 10-13 6302157-2 1983 The ATPase pumps protons into the vesicle; a pair of protons is then exchanged for each catecholamine taken up. Catecholamines 88-101 dynein axonemal heavy chain 8 Homo sapiens 4-10 6188774-7 1983 Substance P (SP) modulates the secretion of catecholamines and ATP evoked by ACh or nicotine but not that evoked by K+ or veratridine. Catecholamines 44-58 tachykinin precursor 1 Bos taurus 13-15 6137760-1 1983 Tyrosine hydroxylase is considered to be the rate-limiting enzyme in the synthesis of catecholamines in both the central and peripheral nervous system. Catecholamines 86-100 tyrosine hydroxylase Homo sapiens 0-20 6315795-3 1983 Thus, upon exposure of C62B cells to catecholamine a rapid decline (t 1/2 = 6-8 min) in isoproterenol-stimulated adenylate cyclase activity occurs with minimal loss in basal or NaF-stimulated activity. Catecholamines 37-50 C-X-C motif chemokine ligand 8 Homo sapiens 177-180 6315964-4 1983 These results support the hypothesis that catechol estrogens may interfere with catecholamine metabolism by acting as inhibitors of enzymes involved in catecholamine metabolism, such as dihydropteridine reductase. Catecholamines 80-93 quinoid dihydropteridine reductase Homo sapiens 186-212 6315964-4 1983 These results support the hypothesis that catechol estrogens may interfere with catecholamine metabolism by acting as inhibitors of enzymes involved in catecholamine metabolism, such as dihydropteridine reductase. Catecholamines 152-165 quinoid dihydropteridine reductase Homo sapiens 186-212 6142402-5 1983 The immunohistochemical technique relies upon the availability of antisera generated against the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase(DBH), and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 97-110 dopamine beta-hydroxylase Homo sapiens 159-184 6142402-5 1983 The immunohistochemical technique relies upon the availability of antisera generated against the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase(DBH), and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 97-110 dopamine beta-hydroxylase Homo sapiens 185-188 6142402-5 1983 The immunohistochemical technique relies upon the availability of antisera generated against the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase(DBH), and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 97-110 phenylethanolamine N-methyltransferase Homo sapiens 195-233 6186863-1 1983 The potential role of circulating catecholamines in the regulation of plasma renin concentration (PRC) was evaluated in conscious rats. Catecholamines 34-48 renin Rattus norvegicus 77-82 6186863-5 1983 It is concluded that, in the rat, the circulating catecholamines contribute to the control of PRC by modulating renin secretion through stimulation-inhibition mechanisms. Catecholamines 50-64 renin Rattus norvegicus 112-117 6132348-0 1983 Human brainstem catecholamine neuronal anatomy as indicated by immunocytochemistry with antibodies to tyrosine hydroxylase. Catecholamines 16-29 tyrosine hydroxylase Homo sapiens 102-122 6310381-0 1983 Estrogen receptor sites in the developing central nervous system and their relationships to catecholamine systems. Catecholamines 92-105 estrogen receptor 1 Homo sapiens 0-17 6142402-5 1983 The immunohistochemical technique relies upon the availability of antisera generated against the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase(DBH), and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 97-110 phenylethanolamine N-methyltransferase Homo sapiens 235-239 6142402-6 1983 Each of these enzymes catalyzes different steps in catecholamine metabolism and therefore can be used in conjunction with one another to selectively delineate the organization and distribution of neuronal cells and processes containing dopamine (TH), noradrenaline (TH and DBH), and adrenaline (PNMT). Catecholamines 51-64 dopamine beta-hydroxylase Homo sapiens 273-276 6142402-6 1983 Each of these enzymes catalyzes different steps in catecholamine metabolism and therefore can be used in conjunction with one another to selectively delineate the organization and distribution of neuronal cells and processes containing dopamine (TH), noradrenaline (TH and DBH), and adrenaline (PNMT). Catecholamines 51-64 phenylethanolamine N-methyltransferase Homo sapiens 295-299 6402798-3 1983 Exposure to carbamylcholine, veratridine or high K evokes a transient increase in the rate of catecholamine release in association with dopamine beta hydroxylase but not lactate dehydrogenase. Catecholamines 94-107 dopamine beta-hydroxylase Bos taurus 136-161 6306616-2 1983 We have reported that intracisternal administration of synthetic human beta-endorphin increases plasma concentration of catecholamines, apparently by acting at unknown brain sites to increase sympathetic outflow to the adrenal medulla and sympathetic nerves. Catecholamines 120-134 proopiomelanocortin Homo sapiens 71-85 6306616-3 1983 In the present study we examined the possibility that angiotensin II, acting in brain, modulates endorphin-induced catecholamine secretion. Catecholamines 115-128 angiotensinogen Homo sapiens 54-68 6129126-1 1982 To determine if alpha 1-or alpha 2-adrenergic receptors mediate the inhibition of ACTH stimulation of growth hormone secretion, decrease in blood pressure and inhibition of renin secretion produced by release of catecholamines in the brain, drugs with varying amounts of alpha 1- and alpha 2-adrenergic activity were injected directly into the third ventricle in pentobarbital anesthetized dogs. Catecholamines 212-226 renin Canis lupus familiaris 173-178 7150965-1 1982 Medio-basal hypothalamic (MBH) catecholamine mechanisms in the regulation of prolactin and growth hormone (GH) secretion were investigated in unanesthetized rats with chronic indwelling venous cannulae and bilateral MBH directed intracerebral guide cannulae. Catecholamines 31-44 gonadotropin releasing hormone receptor Rattus norvegicus 91-105 6293310-9 1982 It is suggested that the inotropic influence of prolactin is mediated by endogenous catecholamine liberation. Catecholamines 84-97 prolactin Rattus norvegicus 48-57 7155787-1 1982 The reactivity of a number of catechols and catecholamines with regard to the enzymatic O-methylation by catechol-O-methyltransferase (COMT) was studied. Catecholamines 44-58 catechol-O-methyltransferase Homo sapiens 105-133 7155787-1 1982 The reactivity of a number of catechols and catecholamines with regard to the enzymatic O-methylation by catechol-O-methyltransferase (COMT) was studied. Catecholamines 44-58 catechol-O-methyltransferase Homo sapiens 135-139 6127338-0 1982 Phosphorylation and activation of tyrosine hydroxylase mediate the cAMP-induced increase in catecholamine biosynthesis in adrenal chromaffin cells. Catecholamines 92-105 cathelicidin antimicrobial peptide Homo sapiens 67-71 7160182-1 1982 Catechol-O-methyltransferase (COMT) is a key enzyme in the metabolism of catecholamines. Catecholamines 73-87 catechol-O-methyltransferase Rattus norvegicus 0-28 7160182-1 1982 Catechol-O-methyltransferase (COMT) is a key enzyme in the metabolism of catecholamines. Catecholamines 73-87 catechol-O-methyltransferase Rattus norvegicus 30-34 6127400-10 1982 These cholinergic mechanisms for the acute regulation of tyrosine 3-monooxygenase may be activated in vivo by acetylcholine released from preganglionic neurons and thus may play a role in the physiological regulation of catecholamine synthesis in sympathetic ganglia. Catecholamines 220-233 tyrosine hydroxylase Rattus norvegicus 57-81 6292084-9 1982 The renin-stimulating effect of centrally administered PGE2 is, at least in part, dependent on beta-adrenergic receptor stimulation by increased circulating catecholamines. Catecholamines 157-171 renin Rattus norvegicus 4-9 7150354-7 1982 The increase in PNMT activity appears to be a compensatory response to depletion of medullary catecholamines by DNLCA or alpha-methyltyrosine. Catecholamines 94-108 phenylethanolamine-N-methyltransferase Rattus norvegicus 16-20 6956674-2 1982 PST and membrane-bound COMT were found to have the lowest Km values for both catecholamines. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 23-27 7154666-6 1982 The discussion of the results was correlated to the brain catecholamines postulated to be neurotransmitters involved in the control of corticotropin and prolactin pituitary secretion. Catecholamines 58-72 prolactin Rattus norvegicus 153-162 7124944-0 1982 Catecholamine-thyroid hormone interaction on myocardial ornithine decarboxylase. Catecholamines 0-13 ornithine decarboxylase 1 Rattus norvegicus 56-79 7124944-3 1982 Myocardial ornithine decarboxylase (ODC) activity also responds to catecholamine and thyroid hormone stimulation. Catecholamines 67-80 ornithine decarboxylase 1 Rattus norvegicus 11-34 7124944-3 1982 Myocardial ornithine decarboxylase (ODC) activity also responds to catecholamine and thyroid hormone stimulation. Catecholamines 67-80 ornithine decarboxylase 1 Rattus norvegicus 36-39 6956674-5 1982 At concentrations less than 100 microM, soluble COMT contributes less than 5% to the total catabolism of either catecholamine. Catecholamines 112-125 catechol-O-methyltransferase Homo sapiens 48-52 6128682-0 1982 Facilitation of stimulation-evoked catecholamine release by somatostatin in dog perfused adrenal glands. Catecholamines 35-48 somatostatin Canis lupus familiaris 60-72 6821132-3 1982 Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and, likewise, is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms. Catecholamines 224-238 chromogranin A Homo sapiens 133-147 6128682-1 1982 The effect of somatostatin on the catecholamine (CA) release from the chromaffin cells was determined on the isolated dog adrenals perfused with 1.8 mM Ca2+ containing fluid except indicated. Catecholamines 34-47 somatostatin Canis lupus familiaris 14-26 6294636-1 1982 Catecholamine and serotonin neurons in the hypothalamus regulate the secretion of corticotropin releasing factor (CRF). Catecholamines 0-13 corticotropin releasing hormone Rattus norvegicus 82-112 6215972-7 1982 These results suggest the following: first, PRL release is stimulated by centrally injected [Asu1,7]eel CT, the action site of which may exist in the extrahypothalamic area; second, brain catecholamines may be involved in the mechanism of [Asu1,7]eel CT-evoked PRL release; third, the C-terminal portion of the peptide may play an important role in stimulating PRL release. Catecholamines 188-202 prolactin Rattus norvegicus 44-47 6215972-7 1982 These results suggest the following: first, PRL release is stimulated by centrally injected [Asu1,7]eel CT, the action site of which may exist in the extrahypothalamic area; second, brain catecholamines may be involved in the mechanism of [Asu1,7]eel CT-evoked PRL release; third, the C-terminal portion of the peptide may play an important role in stimulating PRL release. Catecholamines 188-202 prolactin Rattus norvegicus 261-264 6215972-7 1982 These results suggest the following: first, PRL release is stimulated by centrally injected [Asu1,7]eel CT, the action site of which may exist in the extrahypothalamic area; second, brain catecholamines may be involved in the mechanism of [Asu1,7]eel CT-evoked PRL release; third, the C-terminal portion of the peptide may play an important role in stimulating PRL release. Catecholamines 188-202 prolactin Rattus norvegicus 261-264 6184894-7 1982 The regulatory function of SP seems to be connected with the system of endogenous opiates and with the system of catecholamines. Catecholamines 113-127 tachykinin precursor 1 Homo sapiens 27-29 7117550-4 1982 These data lead us to conclude that ATP catalyzes bidirectional catecholamine flux across the granule membrane (not net accumulation) by an ATPase-dependent mechanism. Catecholamines 64-77 dynein axonemal heavy chain 8 Homo sapiens 140-146 6184757-1 1982 A method has been developed for LC-EC quantitation of 5-hydroxyindoles (5-HT, 5-HTP, 5-HIAA and N-acetyl-5-HT) and the catecholamine metabolite HVA from brain tissue and biological fluids such as CSF. Catecholamines 119-132 colony stimulating factor 2 Homo sapiens 196-199 6294637-2 1982 One hundred twenty-five mU/ml of ACTH 1-39 significantly augmented the catecholamine induced positive inotropism as seen by shortening the time to peak tension (10.6%, p = 0.01) and increasing peak isometric tension (3.5 times, p = 0.001). Catecholamines 71-84 proopiomelanocortin Canis lupus familiaris 33-37 6181847-1 1982 Substance P (SP) and somatostatin (SRIF) are known to inhibit the nicotine-induced release of catecholamines (CAs) from isolated adrenal chromaffin cells in culture22,24. Catecholamines 94-108 tachykinin precursor 1 Homo sapiens 0-11 7178654-0 1982 Effects of phenylethanolamine N-methyltransferase inhibitors on rat brain catecholamine levels and body temperature. Catecholamines 74-87 phenylethanolamine-N-methyltransferase Rattus norvegicus 11-49 6181847-1 1982 Substance P (SP) and somatostatin (SRIF) are known to inhibit the nicotine-induced release of catecholamines (CAs) from isolated adrenal chromaffin cells in culture22,24. Catecholamines 110-113 tachykinin precursor 1 Homo sapiens 0-11 6291110-1 1982 Catecholamine release by La3+, Ce3+, Pr3+, or Nd3+ from isolated bovine adrenals requires the presence of calcium in the perfusing medium. Catecholamines 0-13 NADH dehydrogenase subunit 3 Bos taurus 46-49 6127720-2 1982 In a recent article, Wise [83] argued that dopamine is the catecholamine critically involved in the central mediation of reward. Catecholamines 59-72 sclerostin domain containing 1 Homo sapiens 21-25 6183680-1 1982 Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Catecholamines 63-77 dopamine beta-hydroxylase Rattus norvegicus 138-163 6178533-3 1982 Purification of urine on Bio-Rad prepacked ion-exchange columns followed by Sephadex G10 resulted in a reliable, fast (200 samples processed per week) method for determination of free catecholamines in urine. Catecholamines 184-198 RRAD, Ras related glycolysis inhibitor and calcium channel regulator Homo sapiens 29-32 7121616-4 1982 This implies an insignificant role for plasma membrane COMT although reported altered kinetic behaviour could elevate microsomal COMT to a supporting role in the regulation of catecholamine concentration in the circulation. Catecholamines 176-189 catechol-O-methyltransferase Rattus norvegicus 129-133 7104386-8 1982 These observations suggest that regulation of glycogenolysis and gluconeogenesis in rabbits by glucagon and catecholamines is at least partially due to activation of glycogen phosphorylase and inhibition of pyruvate kinase. Catecholamines 108-122 pyruvate kinase PKLR Oryctolagus cuniculus 207-222 6183680-1 1982 Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Catecholamines 63-77 dopamine beta-hydroxylase Rattus norvegicus 165-168 6183680-1 1982 Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Catecholamines 63-77 phenylethanolamine-N-methyltransferase Rattus norvegicus 214-218 6756553-1 1982 Catecholamine innervation of vasopressin and oxytocin neurons in the rhesus monkey hypothalamus. Catecholamines 0-13 arginine vasopressin Rattus norvegicus 29-40 6129044-0 1982 Relationship of catecholamines and LHRH: light microscopic study. Catecholamines 16-30 gonadotropin releasing hormone 1 Mus musculus 35-39 6129044-4 1982 These studies revealed the presence of catecholamine fibers in the areas of LHRH cells. Catecholamines 39-52 gonadotropin releasing hormone 1 Mus musculus 76-80 6129044-5 1982 Co-localization of TH and LHRH with a dual immunoperoxidase technique in single 20-25 micron sections showed a juxtaposition of catecholamine fibers on LHRH cells and their dendrites. Catecholamines 128-141 tyrosine hydroxylase Mus musculus 19-21 6129044-5 1982 Co-localization of TH and LHRH with a dual immunoperoxidase technique in single 20-25 micron sections showed a juxtaposition of catecholamine fibers on LHRH cells and their dendrites. Catecholamines 128-141 gonadotropin releasing hormone 1 Mus musculus 26-30 6129044-5 1982 Co-localization of TH and LHRH with a dual immunoperoxidase technique in single 20-25 micron sections showed a juxtaposition of catecholamine fibers on LHRH cells and their dendrites. Catecholamines 128-141 gonadotropin releasing hormone 1 Mus musculus 152-156 6129044-9 1982 These results support a direct action of catecholamines on the LHRH system and suggest that LHRH may influence dopamine function. Catecholamines 41-55 gonadotropin releasing hormone 1 Mus musculus 63-67 6756553-7 1982 Oxytocin neurons were clustered in this relatively catecholamine poor region, whereas the vasopressin-containing neurons were more abundantly found in the catecholamine rich region. Catecholamines 155-168 arginine vasopressin Rattus norvegicus 90-101 6756553-10 1982 These observations confirm our earlier reports, in rat hypothalamus, that the norepinephrine innervation of the hypothalamic magnocellular neurons as seen with catecholamine histofluorescence favors the vasopressin-containing neurons over those located within the same nuclei which synthesize another neurohyphysial principal, oxytocin. Catecholamines 160-173 arginine vasopressin Rattus norvegicus 203-214 7084115-5 1982 Histofluorescence examination of additional explants revealed that endogenous catecholamine was still present on day 2 within varicosities in the supraoptic nucleus, but diminished by days 3 and 4, suggesting that endogenous NE could influence basal VP release. Catecholamines 78-91 arginine vasopressin Rattus norvegicus 250-252 6176582-4 1982 The rank order of catecholamines, phenothiazines, and related drugs in competing for 3H-agonist binding is indicative of interactions with a D-2 dopamine receptor. Catecholamines 18-32 dopamine receptor D2 Bos taurus 141-162 6125222-1 1982 Three human catecholamine-secreting adrenal medullary tumours, identified as phaeochromocytoma, were found to contain 774, 168, and 78 pmol/g of somatostatin-like immunoreactivity (SLI), compared to 40 pmol/g in a sample of normal human adrenal medulla. Catecholamines 12-25 SHC adaptor protein 2 Homo sapiens 145-179 7093704-2 1982 The cells which contain catecholamine and project to the lumbar spinal cord of the cat are most densely concentrated in the Kolliker-Fuse nucleus. Catecholamines 24-37 Polykaryocytosis inducer Homo sapiens 133-137 7044409-5 1982 The decreased activity of the renin-aldosterone axis after administration of L-dopa may be attributed to an accumulation of dopamine and catecholamines in the brain, resulting in a diminution of sympathetic outflow from the central nervous system. Catecholamines 137-151 renin Homo sapiens 30-35 6806317-3 1982 However, when CNS stores of both NE and dopamine (DA) were depleted by the subcutaneous administration of the tyrosine hydroxylase inhibitor alpha-methyl-rho-tyrosine (alpha-MT), TRH concentrations in the brain were not significantly altered.FLA-63 and alpha-MT did not significantly reduce pancreatic catecholamine concentrations, indicating that in the basal state, these agents predominantly deplete central catecholamine stores. Catecholamines 302-315 thyrotropin releasing hormone Rattus norvegicus 179-182 6806317-3 1982 However, when CNS stores of both NE and dopamine (DA) were depleted by the subcutaneous administration of the tyrosine hydroxylase inhibitor alpha-methyl-rho-tyrosine (alpha-MT), TRH concentrations in the brain were not significantly altered.FLA-63 and alpha-MT did not significantly reduce pancreatic catecholamine concentrations, indicating that in the basal state, these agents predominantly deplete central catecholamine stores. Catecholamines 411-424 thyrotropin releasing hormone Rattus norvegicus 179-182 7101471-0 1982 [Functional importance of catecholamine metabolism in the regulation of AMP-aminohydrolase activity in mitochondria of the heart and other organs]. Catecholamines 26-39 adenosine monophosphate deaminase 3 Homo sapiens 72-90 7040390-13 1982 These results provide evidence that exercise and catecholamines activate sugar transport by a process that requires protein synthesis for its reversal, while the increases in permeability induced by insulin and trypsin involve a different mechanism. Catecholamines 49-63 insulin Homo sapiens 199-206 7040232-2 1982 Catecholamine depletion decreased blood pressure and stimulated vasopressin levels in all rats, but significantly more so in the anephric ones. Catecholamines 0-13 arginine vasopressin Rattus norvegicus 64-75 7040232-6 1982 Catecholamine levels were inversely correlated with those of plasma vasopressin, which were far greater in anephric rats through both stimulation and accumulation. Catecholamines 0-13 arginine vasopressin Rattus norvegicus 68-79 7043177-0 1982 Variations in plasma glucose, insulin, growth hormone and catecholamines in response to insulin in trained and non-trained subjects. Catecholamines 58-72 insulin Homo sapiens 88-95 7098414-1 1982 In the myocardium of the weightless and centrifuged rats flown for 18.5 days onboard the biosatellite Cosmos-936 the catecholamine concentration and activity of enzymes involved in their synthesis and degradation--dopamine-beta-hydroxylase, monoamine oxidase and catechol-O-methyl transferase--were measured. Catecholamines 117-130 dopamine beta-hydroxylase Rattus norvegicus 214-239 7101471-1 1982 The paper deals with main pathways for conversion of catecholamines and their effect on the activity of AMP-aminohydrolase in mitochondria of the heart, liver, brain, kidneys and blood serum. Catecholamines 53-67 adenosine monophosphate deaminase 3 Homo sapiens 104-122 7101471-3 1982 Adrenoxyl (stabilized adrenochrome) duplicates the catecholamine effect with respect to AMP-aminohydrolase in certain organs. Catecholamines 51-64 adenosine monophosphate deaminase 3 Homo sapiens 88-106 7101471-4 1982 A three-hour electric stimulation of the aorta arc is accompanied by activation of AMP-aminohydrolase in the heart and blood serum, which is, probably, associated with changes in the balance and metabolism of tissue catecholamines. Catecholamines 216-230 adenosine monophosphate deaminase 3 Homo sapiens 83-101 7046745-0 1982 Direct inhibition of brain sepiapterin reductase by a catecholamine and an indoleamine. Catecholamines 54-67 sepiapterin reductase Homo sapiens 27-48 6124065-3 1982 Since the beta 1-receptors prevail in the human myocardium and the catecholamine-induce lipolysis is also realized above all through the beta 1-receptors, the blocking of beta 1-receptors fulfils the therapeutic aim to block the increase of heart rate and free fatty acids undesired under load and on account of the less specific side effects it is to be preferred to the more comprehensive beta 1-blocking in the long-term therapy of cardiovascular diseases. Catecholamines 67-80 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 137-143 6124065-3 1982 Since the beta 1-receptors prevail in the human myocardium and the catecholamine-induce lipolysis is also realized above all through the beta 1-receptors, the blocking of beta 1-receptors fulfils the therapeutic aim to block the increase of heart rate and free fatty acids undesired under load and on account of the less specific side effects it is to be preferred to the more comprehensive beta 1-blocking in the long-term therapy of cardiovascular diseases. Catecholamines 67-80 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 137-143 6124065-3 1982 Since the beta 1-receptors prevail in the human myocardium and the catecholamine-induce lipolysis is also realized above all through the beta 1-receptors, the blocking of beta 1-receptors fulfils the therapeutic aim to block the increase of heart rate and free fatty acids undesired under load and on account of the less specific side effects it is to be preferred to the more comprehensive beta 1-blocking in the long-term therapy of cardiovascular diseases. Catecholamines 67-80 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 137-143 7065211-3 1982 Mg2+ blocks the spontaneous release of catecholamines from dogfish chromaffin tissue but does not alter the norepinephrine-induced contraction of the isolated dogfish artery. Catecholamines 39-53 mucin 7, secreted Homo sapiens 0-3 7065211-4 1982 In vivo infusion of Mg2+ causes a significant decrease in resting catecholamine levels and diminishes the catecholamine release caused by K+ challenge. Catecholamines 66-79 mucin 7, secreted Homo sapiens 20-23 6121590-1 1982 Significant amounts of somatostatin-like immunoreactivity (SLI) were detected in the extract of a human catecholamine-secreting adrenal medullary tumour. Catecholamines 104-117 SHC adaptor protein 2 Homo sapiens 59-62 7065211-4 1982 In vivo infusion of Mg2+ causes a significant decrease in resting catecholamine levels and diminishes the catecholamine release caused by K+ challenge. Catecholamines 106-119 mucin 7, secreted Homo sapiens 20-23 7065211-5 1982 Both Mg2+ and phentolamine block the pressor action of K+, Mg2+ by preventing the K+-induced release of catecholamines and phentolamine by preventing the circulating catecholamines from interacting with alpha-adrenergic receptor sites. Catecholamines 104-118 mucin 7, secreted Homo sapiens 5-8 7065211-5 1982 Both Mg2+ and phentolamine block the pressor action of K+, Mg2+ by preventing the K+-induced release of catecholamines and phentolamine by preventing the circulating catecholamines from interacting with alpha-adrenergic receptor sites. Catecholamines 104-118 mucin 7, secreted Homo sapiens 59-62 7065211-5 1982 Both Mg2+ and phentolamine block the pressor action of K+, Mg2+ by preventing the K+-induced release of catecholamines and phentolamine by preventing the circulating catecholamines from interacting with alpha-adrenergic receptor sites. Catecholamines 166-180 mucin 7, secreted Homo sapiens 5-8 7065211-5 1982 Both Mg2+ and phentolamine block the pressor action of K+, Mg2+ by preventing the K+-induced release of catecholamines and phentolamine by preventing the circulating catecholamines from interacting with alpha-adrenergic receptor sites. Catecholamines 166-180 mucin 7, secreted Homo sapiens 59-62 6175808-1 1982 Acute hypovolemia induced by bleeding (5 ml/300 g body weight) halothane-anesthetized (0.8% in oxygen) rats is attended by hypotension, bradycardia, and increases in plasma renin, vasopressin, and catecholamine levels. Catecholamines 197-210 renin Rattus norvegicus 173-178 6121595-5 1982 5 Since the increase in ODC activity was blocked by a beta-adrenoceptor antagonist (propranolol) and enzyme activity was stimulated by terbutaline, a beta 2-agonist, we conclude that beta 2-adrenoceptors are selectively coupled to the regulation of murine cardiac ODC activity following catecholamine stimulation. Catecholamines 287-300 ornithine decarboxylase, structural 1 Mus musculus 24-27 6123194-6 1982 In the catecholamine regulation of succinate dehydrogenase and ATPase activities in all the tissues studied as well as of cytochrome c oxidase activity in heart tissue the quinoid oxidation products were apparently involved. Catecholamines 7-20 dynein axonemal heavy chain 8 Homo sapiens 63-69 7079574-7 1982 Barium in the tissue is proportional to secretion, but it appears that only part of the Cd2+ entering the cells is involved in initiating adrenal catecholamine release. Catecholamines 146-159 CD2 molecule Homo sapiens 88-91 7070709-0 1982 Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells. Catecholamines 56-70 proopiomelanocortin Bos taurus 11-31 6279105-4 1982 A preliminary hypothesis is: in vivo alpha 1 is rapid in onset, short-lived, utilises internal Ca2+, prefers alkalosis and responds to short-term stimuli such as short bursts of nerve impulses or bolus injections of catecholamines; alpha 2 is slower in onset, longer-lived, utilises external Ca2+, prefers acidosis and responds to more prolonged stimuli such as circulating catecholamines; in vitro these categories of response occur but antagonists fail to define an alpha 1/alpha 2 split, suggesting that some critical factor is missing in vitro. Catecholamines 216-230 adrenoceptor alpha 1D Homo sapiens 37-44 6279105-4 1982 A preliminary hypothesis is: in vivo alpha 1 is rapid in onset, short-lived, utilises internal Ca2+, prefers alkalosis and responds to short-term stimuli such as short bursts of nerve impulses or bolus injections of catecholamines; alpha 2 is slower in onset, longer-lived, utilises external Ca2+, prefers acidosis and responds to more prolonged stimuli such as circulating catecholamines; in vitro these categories of response occur but antagonists fail to define an alpha 1/alpha 2 split, suggesting that some critical factor is missing in vitro. Catecholamines 374-388 adrenoceptor alpha 1D Homo sapiens 37-44 7092762-1 1982 Dopamine-beta-hydroxylase (DBH) is unique among the catecholamine biosynthetic enzymes in that release from sympathoadrenal cells during neurotransmission is an integral part of the enzyme"s physiology. Catecholamines 52-65 dopamine beta-hydroxylase Rattus norvegicus 0-25 7092762-1 1982 Dopamine-beta-hydroxylase (DBH) is unique among the catecholamine biosynthetic enzymes in that release from sympathoadrenal cells during neurotransmission is an integral part of the enzyme"s physiology. Catecholamines 52-65 dopamine beta-hydroxylase Rattus norvegicus 27-30 6180787-4 1982 The catecholamine modulation of the intrinsic rhythmical contractions of the portal vein may be complemented by SP released from intramural nerves and VIP released from the adventitial nerves. Catecholamines 4-17 vasoactive intestinal peptide Rattus norvegicus 151-154 7066709-0 1982 Acetylcholinesterase in pontomedullary catecholamine neurons of the adult albino rat. Catecholamines 39-52 acetylcholinesterase Rattus norvegicus 0-20 7066709-4 1982 Our results, in both randomly sampled and serially sectioned material, unequivocally establish the presence of AChE in all pontomedullary cell groups emitting catecholamine fluorescence, the majority of which are known to consist of noradrenaline perikarya. Catecholamines 159-172 acetylcholinesterase Rattus norvegicus 111-115 7066709-7 1982 It remains for future study to determine whether AChE in brain catecholamine neurons indicates their cholinoceptivity or subserves the catabolism of other neuromediators such as substance P. Catecholamines 63-76 acetylcholinesterase Rattus norvegicus 49-53 7036752-8 1982 Cross-correlation analyses indicated that fluctuations in the catecholamines were significantly negatively correlated with oscillations in insulin and were unrelated to fluctuations in glucagon. Catecholamines 62-76 insulin Homo sapiens 139-146 7036752-9 1982 These fluctuations in plasma catecholamines may be related to mechanisms controlling the periodicity observed in plasma insulin and glucose. Catecholamines 29-43 insulin Homo sapiens 120-127 6762173-0 1982 [Effect of alpha- or beta-adrenergic antagonists on catecholamine-induced changes in the glucose and insulin levels of the blood plasma of swine]. Catecholamines 52-65 insulin Sus scrofa 101-108 7084126-3 1982 In the remaining 2 patients dispite increase of plasma catecholamines DBH activity remained unchanged during surgical manipulation of the pheochromocytoma. Catecholamines 55-69 dopamine beta-hydroxylase Homo sapiens 70-73 6130677-5 1982 It is postulated that the effect of prazosin is mediated by an increase in circulating catecholamines acting on the pancreatic beta-cell alpha 2-adrenoceptors, which are responsible for the well-known inhibitory action of alpha-adrenergic agents upon the release of insulin. Catecholamines 87-101 insulin Homo sapiens 266-273 6282185-1 1982 Sympathetic outflow influences the renal release of renin through modifications of the tonic activity of the renal nerves and the plasma concentration of catecholamines. Catecholamines 154-168 renin Homo sapiens 52-57 6280799-1 1982 1 The primary effect of catecholamines was to lighten Anolis skin previously darkened by alpha-melanocyte-stimulating hormone (alpha-MSH). Catecholamines 24-38 proopiomelanocortin Homo sapiens 89-125 6122546-2 1982 Insulin is the major anabolic hormone, and its actions are antagonized by rapidly acting catabolic hormones, such as glucagon and the catecholamines, and by others such as cortisol, growth hormone and the thyroid hormones, which generally have more delayed effects. Catecholamines 134-148 insulin Homo sapiens 0-7 6280799-1 1982 1 The primary effect of catecholamines was to lighten Anolis skin previously darkened by alpha-melanocyte-stimulating hormone (alpha-MSH). Catecholamines 24-38 proopiomelanocortin Homo sapiens 127-136 6280799-3 1982 Subsequent experiments were concerned with the effect of low catecholamine concentrations on alpha-MSH action. Catecholamines 61-74 proopiomelanocortin Homo sapiens 93-102 6183076-0 1982 Relation of substance P to stress and catecholamine metabolism. Catecholamines 38-51 tachykinin 1 Mus musculus 12-23 6280799-5 1982 3 alpha-MSH dose-response curves were shifted, in parallel, to the right in the presence of the catecholamines, noradrenaline, adrenaline and dopamine, and Lineweaver-Burke plots and Arunlakshana-Schild plots indicated that the catecholamines antagonized MSH action by a competitive mechanism. Catecholamines 96-110 proopiomelanocortin Homo sapiens 2-11 6280799-5 1982 3 alpha-MSH dose-response curves were shifted, in parallel, to the right in the presence of the catecholamines, noradrenaline, adrenaline and dopamine, and Lineweaver-Burke plots and Arunlakshana-Schild plots indicated that the catecholamines antagonized MSH action by a competitive mechanism. Catecholamines 228-242 proopiomelanocortin Homo sapiens 2-11 6130933-0 1982 Effect of nerve growth factor on catecholamine metabolism in a human neuroblastoma clone (SY5Y). Catecholamines 33-46 nerve growth factor Homo sapiens 10-29 6130933-4 1982 Careful examination of catecholamine synthesizing enzyme specific activities and catecholamine concentrations in nerve growth factor-treated SY5Y cells showed a small elevation of tyrosine hydroxylase, no change in dopamine-beta-hydroxylase or in dopamine or norepinephrine intracellular concentrations. Catecholamines 23-36 nerve growth factor Homo sapiens 113-132 6130933-4 1982 Careful examination of catecholamine synthesizing enzyme specific activities and catecholamine concentrations in nerve growth factor-treated SY5Y cells showed a small elevation of tyrosine hydroxylase, no change in dopamine-beta-hydroxylase or in dopamine or norepinephrine intracellular concentrations. Catecholamines 81-94 nerve growth factor Homo sapiens 113-132 6127639-2 1982 The catecholamines dopamine (DA) and norepinephrine (NE) inhibited the release of alpha-MSH from pituitary glands incubated in vitro. Catecholamines 4-18 proopiomelanocortin Rattus norvegicus 82-91 7037696-9 1982 The correlation between the intensity of the immunocytochemical staining for NGF and the catecholamine fluorescence adjacent to the granular ducts suggests a trophic influence of the NGF-containing granular ducts on their sympathetic innervation. Catecholamines 89-102 nerve growth factor Mus musculus 183-186 7054231-2 1982 Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Catecholamines 0-14 gonadotropin releasing hormone receptor Rattus norvegicus 42-56 7054231-2 1982 Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Catecholamines 0-14 gonadotropin releasing hormone receptor Rattus norvegicus 58-60 7054231-2 1982 Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Catecholamines 0-14 gonadotropin releasing hormone receptor Rattus norvegicus 167-169 7054231-4 1982 Furthermore, many of the agents used to study the role of catecholamines in GH regulation are not selective in that they affect adrenergic as well as nor-adrenergic and/or dopaminergic neurotransmission. Catecholamines 58-72 gonadotropin releasing hormone receptor Rattus norvegicus 76-78 6290925-2 1982 Catecholamines interacting with the beta-adrenoceptor stimulate adenylate cyclase activity, enhance cyclic AMP formation and thereby trigger the release of alpha-melanocyte-stimulating hormone (alpha-MSH). Catecholamines 0-14 proopiomelanocortin Rattus norvegicus 156-192 6290925-2 1982 Catecholamines interacting with the beta-adrenoceptor stimulate adenylate cyclase activity, enhance cyclic AMP formation and thereby trigger the release of alpha-melanocyte-stimulating hormone (alpha-MSH). Catecholamines 0-14 proopiomelanocortin Rattus norvegicus 194-203 7108528-0 1982 On the mechanism of the involvement of monoamine oxidase in catecholamine-stimulated prostaglandin biosynthesis in particulate fraction of rat brain homogenates: role of hydrogen peroxide. Catecholamines 60-73 monoamine oxidase A Rattus norvegicus 39-56 7108528-1 1982 The mechanism of involvement of monoamine oxidase (MAO) in catecholamine-stimulated prostaglandin (PG) biosynthesis was studied in the particulate fraction of rat brain homogenates. Catecholamines 59-72 monoamine oxidase A Rattus norvegicus 32-49 7108528-1 1982 The mechanism of involvement of monoamine oxidase (MAO) in catecholamine-stimulated prostaglandin (PG) biosynthesis was studied in the particulate fraction of rat brain homogenates. Catecholamines 59-72 monoamine oxidase A Rattus norvegicus 51-54 7108528-9 1982 During the enzymatic decomposition of catecholamines MAO produces H2O2, which stimulates endoperoxide synthesis. Catecholamines 38-52 monoamine oxidase A Rattus norvegicus 53-56 6290925-3 1982 Catecholamines interacting with a D-2 dopamine receptor (in the classification schema of Kebabian and Calne) diminish adenylate cyclase activity and thereby decrease the capacity of IL cells to synthesize cyclic AMP. Catecholamines 0-14 dopamine receptor D2 Rattus norvegicus 34-55 6278463-0 1982 [Catecholamine regulation of the liver and kidney ATPase activity in mice]. Catecholamines 1-14 dynein, axonemal, heavy chain 8 Mus musculus 50-56 7133376-0 1982 Assay of human erythrocyte catechol-o-methyltransferase activity with naturally occurring catecholamines as substrates. Catecholamines 90-104 catechol-O-methyltransferase Homo sapiens 27-55 20487903-4 1982 The changes of biopterin concentration by TRH administration indicate that biopterin may be a regulatory factor in catecholamine biosynthesis. Catecholamines 115-128 thyrotropin releasing hormone Mus musculus 42-45 6278463-5 1982 The following scheme of the mechanism of catecholamine (CA) effect on Na+, K+-ATPase is suggested: CA leads to beta-adrenoreceptors leads to adenylate cyclase leads to cAMP leads to protein kinase leads to Na+, K+-ATPase. Catecholamines 41-54 dynein, axonemal, heavy chain 8 Mus musculus 78-84 6278463-5 1982 The following scheme of the mechanism of catecholamine (CA) effect on Na+, K+-ATPase is suggested: CA leads to beta-adrenoreceptors leads to adenylate cyclase leads to cAMP leads to protein kinase leads to Na+, K+-ATPase. Catecholamines 41-54 dynein, axonemal, heavy chain 8 Mus musculus 214-220 7027713-0 1981 The relation between catecholamines, glucagon and pancreatic polypeptide during hypoglycaemia in man. Catecholamines 21-35 pancreatic polypeptide Homo sapiens 50-72 6801733-8 1982 Finally, histochemical studies demonstrated stimulation of uterine catecholamine levels (norepinephrine) by arachidonic acid, PGF2 alpha and bradykinin. Catecholamines 67-80 kininogen 1 Homo sapiens 141-151 6121070-6 1981 These results suggest that neurotensin may produce an immediate depressor response (the first phase) partly through a histamine-mediated process, and the second pressor response is produced by catecholamines released from the adrenal medulla through a histamine-mediated process. Catecholamines 193-207 neurotensin Rattus norvegicus 27-38 6945304-1 1981 Aryl sulfotransferase IV (EC 2.8.2.1), purified to homogeneity from male rat liver, catalyzes the sulfation of a variety of substituted phenols, including catecholamines, tyrosine esters, and peptides containing NH2-terminal tyrosine residues. Catecholamines 155-169 sulfotransferase family 1A member 1 Rattus norvegicus 0-24 6274671-0 1981 Excitability ot beta-endorphin, morphine and catecholamines of the vas deferens of the rat at different stages of development. Catecholamines 45-59 arginine vasopressin Rattus norvegicus 67-70 7295808-4 1981 (2) The phenothiazine, trifluoperazine, a purported specific inhibitor of calmodulin, completely blocks the stimulation by catecholamines without affecting the response to the other two hormones. Catecholamines 123-137 calmodulin 1 Rattus norvegicus 74-84 7298141-8 1981 Plasma catecholamines were differentially affected by the peptides:isoleucine5 AII significantly increased plasma NE concentration by 82% compared to saline-infused rats (p less than 0.01). Catecholamines 7-21 angiotensinogen Rattus norvegicus 79-82 7296167-3 1981 Catecholamine secretion evoked by Ca(2+) reintroduction in K(+)-free solution (0-K(+)) was also proportional to [Na(+)](o) and greater the longer the time of exposure of the gland to 0-K(+) solution.3 The ionophore X537A also mimicked the ouabain effects, since Ca(2+) reintroduction to glands treated with this agent (25 muM) caused a sharp secretory response. Catecholamines 0-13 latexin Homo sapiens 322-325 6792934-15 1981 The present findings are ascribed to inhibition by insulin of catecholamine inotropic action on myocardium. Catecholamines 62-75 LOC105613195 Ovis aries 51-58 6117601-0 1981 Circadian variations in the activity of tyrosine hydroxylase, tyrosine aminotransferase, and tryptophan hydroxylase: relationship to catecholamine metabolism. Catecholamines 133-146 tyrosine hydroxylase Rattus norvegicus 40-115 6117601-5 1981 This supports the idea that although tyrosine hydroxylase is the rate-limiting enzyme in the synthesis of catecholamines, other factors must also be involved in the in vivo regulation of this process. Catecholamines 106-120 tyrosine hydroxylase Rattus norvegicus 37-57 7284805-4 1981 These results may reflect a role of MAO in the circadian variation of the concentrations of catecholamines in the brain stem. Catecholamines 92-106 monoamine oxidase A Rattus norvegicus 36-39 6274461-2 1981 2 The positive inotropic response to insulin remained unaltered in atria depleted of catecholamine or when beta-adrenoceptors were blocked by addition of propranolol to the organ bath. Catecholamines 85-98 insulin Cavia porcellus 37-44 6116521-1 1981 Mice of the inbred strain BALB/cJ have more midbrain dopaminergic cell bodies and greater activity of the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), in the nigrostriatal and mesolimbic dopaminergic systems than mice of the CBA/J strain. Catecholamines 106-119 tyrosine hydroxylase Mus musculus 141-161 6272813-0 1981 Effect of catecholamines on ornithine decarboxylase activity in the testis of immature rat. Catecholamines 10-24 ornithine decarboxylase 1 Rattus norvegicus 28-51 6271155-1 1981 1 Relationship between plasma catecholamines (measured as noradrenaline and adrenaline) and plasma renin activity (PRA) were examined at rest and during passive head-up tilting for 30 min in nine normal subjects, before and after treatment with propranolol 160 mg daily for 7 days. Catecholamines 30-44 renin Homo sapiens 99-104 7296879-0 1981 Determination of free and conjugated catecholamines and L-3,4-dihydroxyphenylalanine in plasma and urine: evidence for a catechol-O-methyltransferase inhibitor in uraemia. Catecholamines 37-51 catechol-O-methyltransferase Homo sapiens 121-149 6270584-6 1981 administration of human beta-endorphin (25 microgram or 7.25 nmol) produced much greater plasma responses of all three catecholamines than seen with DALA. Catecholamines 119-133 proopiomelanocortin Homo sapiens 24-38 6270584-8 1981 dose of naloxone, which had been shown previously to inhibit the plasma catecholamine responses to beta-endorphin, failed to inhibit plasma catecholamine responses to DALA. Catecholamines 72-85 proopiomelanocortin Homo sapiens 99-113 7018642-1 1981 We employed a delayed feeding paradigm to assess regional brain catecholamine changes associated with insulin-elicited glucoprivic feeding. Catecholamines 64-77 insulin Homo sapiens 102-109 7018642-8 1981 Turnover of catecholamines in the telencephalon was also enhanced after insulin, but the increased activity did not persist into the postglucoprivic period and, in addition, was not altered in any consistent manner by food intake. Catecholamines 12-26 insulin Homo sapiens 72-79 6114114-9 1981 At later stages of development (E 13.5 and E 14.5), the major groups of perikarya and processes labeled for tyrosine hydroxylase have a distribution similar to that previously described by catecholamine fluorescence. Catecholamines 189-202 tyrosine hydroxylase Rattus norvegicus 108-128 7033596-0 1981 [A study on the role of catecholamines in gastrin responses to insulin-induced hypoglycemia (author"s transl)]. Catecholamines 24-38 gastrin Homo sapiens 42-49 6263592-6 1981 These beta-endorphin effects on plasma catecholamines were inhibited by intraarterial naloxone (1.1 mumol/kg), supporting mediation at opioid receptors. Catecholamines 39-53 proopiomelanocortin Homo sapiens 6-20 6263592-7 1981 Pretreatment with the ganglionic blocking agent chlorisondamine inhibited the responses of all three catecholamines to intracisternal beta-endorphin. Catecholamines 101-115 proopiomelanocortin Homo sapiens 134-148 6263592-9 1981 Prior intracisternal administration of hemicholinium-3 blocked the plasma responses of all three catecholamines to intracisternal beta-endorphin, providing evidence for the involvement of central cholinergic neurons in the mechanism mediating beta-endorphin-induced increases in plasma catecholamines. Catecholamines 97-111 proopiomelanocortin Homo sapiens 130-144 6263592-9 1981 Prior intracisternal administration of hemicholinium-3 blocked the plasma responses of all three catecholamines to intracisternal beta-endorphin, providing evidence for the involvement of central cholinergic neurons in the mechanism mediating beta-endorphin-induced increases in plasma catecholamines. Catecholamines 286-300 proopiomelanocortin Homo sapiens 130-144 6263592-9 1981 Prior intracisternal administration of hemicholinium-3 blocked the plasma responses of all three catecholamines to intracisternal beta-endorphin, providing evidence for the involvement of central cholinergic neurons in the mechanism mediating beta-endorphin-induced increases in plasma catecholamines. Catecholamines 286-300 proopiomelanocortin Homo sapiens 243-257 6266594-5 1981 (3) This evidence suggests that COMT may significantly limit the access of catecholamines to postsynaptic receptors, for at least certain types of neuron-to-neuron synaptic actions. Catecholamines 75-89 catechol O-methyltransferase Oryctolagus cuniculus 32-36 6115946-0 1981 Increased cardiac myosin ATPase activity as a biochemical adaptation to running training: enhanced response to catecholamines and a role for myosin phosphorylation. Catecholamines 111-125 myosin heavy chain 14 Homo sapiens 18-24 6273540-3 1981 If it exists, it could be due to catecholamines acting on the actomyosin system, on the sarcoplasmic reticulum (SR) Ca2+ pump or on the release or influx of Ca2+. Catecholamines 33-47 carbonic anhydrase 2 Homo sapiens 116-119 6113874-0 1981 Effect of manipulating central catecholamines on puberty and the surge of luteinizing hormone and gonadotropin releasing hormone induced by pregnant mare serum gonadotropin in female rats. Catecholamines 31-45 gonadotropin releasing hormone 1 Rattus norvegicus 98-128 6273540-17 1981 These results strongly suggest that catecholamines through cyclic AMP stimulate the SR Ca2+ pump, increasing thereby the concentration of Ca2+ within the SR. Catecholamines 36-50 carbonic anhydrase 2 Homo sapiens 87-90 6114000-2 1981 Parallel changes of ACTH, beta-endorphin + beta-LPH and alpha-MSh release were found under all stimulatory and inhibitory conditions by natural and synthetic catecholamine agonists and antagonists. Catecholamines 158-171 proopiomelanocortin Rattus norvegicus 56-65 6273540-17 1981 These results strongly suggest that catecholamines through cyclic AMP stimulate the SR Ca2+ pump, increasing thereby the concentration of Ca2+ within the SR. Catecholamines 36-50 carbonic anhydrase 2 Homo sapiens 138-141 7471434-1 1981 We investigated factors affecting sensitivity and reproducibility of radioenzymic (catechol-O-methyltransferase) measurement of plasma catecholamines. Catecholamines 135-149 catechol-O-methyltransferase Homo sapiens 83-111 6112047-1 1981 Synthetic human beta-endorphin, 7.25 nmol intracisternally, in unanesthetized, freely moving, chronically cannulated, adult male rats increased plasma concentrations of all 3 catecholamines: epinephrine, norepinephrine and dopamine, for the 2 h period studied. Catecholamines 175-189 proopiomelanocortin Homo sapiens 16-30 6111380-1 1981 Monoclonal antibodies were produced against tyrosine hydroxylase (TH), the enzyme catalyzing the rate limiting step in catecholamine neurotransmitter synthesis. Catecholamines 119-132 tyrosine hydroxylase Homo sapiens 44-64 6259214-12 1981 Data indicate that (a) heart cell is a target organ for PTH and may have receptors for the hormone; (b) PTH increases beating rate of heart cells and causes early death of cells; (c) PTH effect appears to be due to calcium entry into heart cells; (d) the locus of action through which PTH induces calcium entry is different from that for catecholamines; and (e) uremic serum has no effect unless it contains PTH. Catecholamines 338-352 parathyroid hormone Rattus norvegicus 104-107 6259214-12 1981 Data indicate that (a) heart cell is a target organ for PTH and may have receptors for the hormone; (b) PTH increases beating rate of heart cells and causes early death of cells; (c) PTH effect appears to be due to calcium entry into heart cells; (d) the locus of action through which PTH induces calcium entry is different from that for catecholamines; and (e) uremic serum has no effect unless it contains PTH. Catecholamines 338-352 parathyroid hormone Rattus norvegicus 104-107 6259214-12 1981 Data indicate that (a) heart cell is a target organ for PTH and may have receptors for the hormone; (b) PTH increases beating rate of heart cells and causes early death of cells; (c) PTH effect appears to be due to calcium entry into heart cells; (d) the locus of action through which PTH induces calcium entry is different from that for catecholamines; and (e) uremic serum has no effect unless it contains PTH. Catecholamines 338-352 parathyroid hormone Rattus norvegicus 104-107 6259214-12 1981 Data indicate that (a) heart cell is a target organ for PTH and may have receptors for the hormone; (b) PTH increases beating rate of heart cells and causes early death of cells; (c) PTH effect appears to be due to calcium entry into heart cells; (d) the locus of action through which PTH induces calcium entry is different from that for catecholamines; and (e) uremic serum has no effect unless it contains PTH. Catecholamines 338-352 parathyroid hormone Rattus norvegicus 104-107 7227455-1 1981 SKF 64139, a potent inhibitor of adrenal and brain phenylethanolamine-N-methyltransferase (PNMT), was found to have effects on catecholamines, serotonin and their metabolites in rat brain which suggest it may act as a potent inhibitor of monoamine oxidase (MAO) "in vivo" after acute administration. Catecholamines 127-141 phenylethanolamine-N-methyltransferase Rattus norvegicus 91-95 7014136-9 1981 There is a negative correlation between plasma catecholamine levels and reduced insulin secretion following the administration of glucose in the postoperative phase. Catecholamines 47-60 insulin Homo sapiens 80-87 6939005-3 1981 It is suggested that a genetically determined deficiency of catecholamine degradative enzymes in the central nervous system or, alternatively, influences of nongenetic hormonal factors could be implicated in the findings of altered erythrocyte COMT activity reported. Catecholamines 60-73 catechol-O-methyltransferase Homo sapiens 244-248 6111380-1 1981 Monoclonal antibodies were produced against tyrosine hydroxylase (TH), the enzyme catalyzing the rate limiting step in catecholamine neurotransmitter synthesis. Catecholamines 119-132 tyrosine hydroxylase Homo sapiens 66-68 7004861-6 1981 From the above results it may be concluded that angiotensinogen production is dependent on thyroid hormones and that renin release depends on beta-adrenergic receptor sensitivity to catecholamines, which is reduced by thyroidectomy. Catecholamines 182-196 renin Rattus norvegicus 117-122 6111224-0 1981 Effect of catecholamines on somatostatin secretion by isolated perfused rat stomach. Catecholamines 10-24 somatostatin Rattus norvegicus 28-40 6111224-1 1981 The secretion of somatostatin-like immunoreactivity (SRIF-LI) by the isolated perfused rat stomach was studied in response to stimulation by catecholamines. Catecholamines 141-155 somatostatin Rattus norvegicus 17-29 6259293-1 1981 In isolated bovine adrenal chromaffin cells, beta-endorphin, dynorphin, and levorphanol caused a dose-dependent inhibition of catecholamine (CA) secretion elicited by acetylcholine (ACh), with an ID50 of 50, 1.3, and 4.3 microM, respectively. Catecholamines 126-139 proopiomelanocortin Bos taurus 45-59 6110339-2 1981 BAR may be important in the placenta for mediating a variety of metabolic and hemodynamic effects of catecholamines including placental hormone synthesis and secretion, placental glycogenolysis, and placental blood flow. Catecholamines 101-115 adrenoceptor beta 2 Homo sapiens 0-3 6113817-0 1981 Effect of inhibitors of catecholamine synthesis on the pituitary response to LH-RH. Catecholamines 24-37 gonadotropin releasing hormone 1 Rattus norvegicus 77-82 6163796-2 1981 The catecholamine synthesizing enzymes TH and DBH, found jointly only in noradrenergic and adrenergic neurons, were localized in cells having a similar morphology and topographical distribution. Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 46-49 6163796-6 1981 Like the catecholamine synthesizing enzymes TH and DBH, enkephalin-like immunoreactivity was localized to perikarya, proximal processes and varicose axon terminals within the area postrema and the adjacent mNTS. Catecholamines 9-22 proenkephalin Rattus norvegicus 56-66 6163104-0 1981 Central catecholamine depletion: effects on physiological growth hormone and prolactin secretion. Catecholamines 8-21 gonadotropin releasing hormone receptor Rattus norvegicus 58-72 6163104-0 1981 Central catecholamine depletion: effects on physiological growth hormone and prolactin secretion. Catecholamines 8-21 prolactin Rattus norvegicus 77-86 6163104-1 1981 The effects of depletion of central nervous system (CNS) catecholamines (CA) upon growth hormone (GH) and prolactin (Prl) secretion were examined in unanaesthetized male rats. Catecholamines 57-71 gonadotropin releasing hormone receptor Rattus norvegicus 82-96 6163104-1 1981 The effects of depletion of central nervous system (CNS) catecholamines (CA) upon growth hormone (GH) and prolactin (Prl) secretion were examined in unanaesthetized male rats. Catecholamines 57-71 gonadotropin releasing hormone receptor Rattus norvegicus 98-100 6109451-1 1981 The carotid bodies, along with the superior cervical ganglia and the adrenal glands, were removed from rabbits and cats and the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, was assayed by the method of Nagatsu (Anal. Catecholamines 195-208 tyrosine hydroxylase Felis catus 140-160 6109451-1 1981 The carotid bodies, along with the superior cervical ganglia and the adrenal glands, were removed from rabbits and cats and the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, was assayed by the method of Nagatsu (Anal. Catecholamines 195-208 tyrosine hydroxylase Felis catus 162-164 6117405-0 1981 Angiotensin II releases catecholamines in dogfish. Catecholamines 24-38 angiotensinogen Homo sapiens 0-14 7020485-3 1981 2) Absolute or relative insulin lack in connection with increased catecholamine release which is know to inhibit insulin secretion. Catecholamines 66-79 insulin Homo sapiens 24-31 7020485-4 1981 3) Decreased sensitivity and responsiveness to insulin in connection with increased levels of counter regulatory hormones (catecholamines, glucagon, growth hormone). Catecholamines 123-137 insulin Homo sapiens 47-54 7325656-4 1981 A stimulation of the mesoblast area by catecholamine is suggested by the analogy between the catecholamine chordal distribution and the adenyl-cyclase activity of the chordo-mesoderm. Catecholamines 39-52 adenylate cyclase 1 Homo sapiens 136-150 6973462-5 1981 The data indicate that both LVP and OXT are capable of influencing the 5-HT and catecholamine levels as late as 4 h after their administration. Catecholamines 80-93 oxytocin/neurophysin I prepropeptide Rattus norvegicus 36-39 7014320-0 1981 The role of catecholamines in the control of gastrin and acid secretion during insulin hypoglycaemia in man. Catecholamines 12-26 gastrin Homo sapiens 45-52 7014320-7 1981 The results suggest that circulating catecholamines contribute to the control of gastrin and acid secretion in man only during circumstances with high plasma catecholamine levels, e.g. severe stress. Catecholamines 37-51 gastrin Homo sapiens 81-88 7014320-7 1981 The results suggest that circulating catecholamines contribute to the control of gastrin and acid secretion in man only during circumstances with high plasma catecholamine levels, e.g. severe stress. Catecholamines 37-50 gastrin Homo sapiens 81-88 6109760-1 1981 Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, catalyzes the conversion of tyrosine to DOPA, Cyclic AMP-dependent protein phosphorylation conditions alter tyrosine hydroxylase activity in rat striatal homogenates. Catecholamines 50-63 tyrosine hydroxylase Rattus norvegicus 0-20 6790402-5 1981 We conclude that TRH causes an increase in blood levels of catecholamines in normal man through undetermined mechanisms. Catecholamines 59-73 thyrotropin releasing hormone Homo sapiens 17-20 6109760-1 1981 Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, catalyzes the conversion of tyrosine to DOPA, Cyclic AMP-dependent protein phosphorylation conditions alter tyrosine hydroxylase activity in rat striatal homogenates. Catecholamines 50-63 tyrosine hydroxylase Rattus norvegicus 186-206 7289544-1 1981 The concentration of catecholamines and activity of enzymes involved in their synthesis and degradation, i. e. dopamine-beta-hydroxylase, monoamine oxidase and catechol-O-methyl transferase, were measured in the myocardium of rats flown for 19.5 days aboard Cosmos-782 and used in the synchronous and vivarium experiments. Catecholamines 21-35 dopamine beta-hydroxylase Rattus norvegicus 111-136 7218373-4 1981 This potentiating action of p-TA was related to the amount of the trace amine applied and was apparently specific for catecholamines, since depressant responses to 5-hydroxytryptamine and gamma-aminobutyric acid were unaffected. Catecholamines 118-132 pre T-cell antigen receptor alpha Rattus norvegicus 28-32 6115365-0 1981 alpha-MSH, MIF-I and melatonin: effects on novelty-induced defecation, plasma 11-OHCS and central catecholamines in rats. Catecholamines 98-112 proopiomelanocortin Rattus norvegicus 0-9 7470728-6 1980 This value was close to the ratio of catecholamines to the "soluble" DBH activity found in the chromaffin granules. Catecholamines 37-51 dopamine beta-hydroxylase Cavia porcellus 69-72 6257311-6 1980 The activation by catecholamines conformed to the physiological beta 2 type response with isoproterenol (1.8 . Catecholamines 18-32 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 64-70 6108354-2 1980 Determination of Mg2+ ATPase activity and catecholamines showed that the distribution of ATPase almost parallelled the distribution of catecholamines. Catecholamines 42-56 dynein axonemal heavy chain 8 Homo sapiens 89-95 7004717-9 1980 Increased activity of the renin-angiotensin and adrenergic nervous systems evoked by stressful stimuli enhances prostaglandin synthesis, which protects organ function from excessive effects of angiotensins and catecholamines. Catecholamines 210-224 renin Homo sapiens 26-31 7002344-0 1980 The role of the renin-angiotensin system in mediation of adrenal catecholamine secretion in the cat induced by intrarenal beta-adrenergic stimulation. Catecholamines 65-78 renin Homo sapiens 16-21 7002344-1 1980 Isoproterenol infusion (0.1 microgram/kg per min) into the renal artery of the cat induced an increase in plasma renin concentration (PRC) from 14.3 +/- 5.7 (mean +/- SE) ng angiotensin I/ml per hr to 56.8 +/- 7.7 after 70 minutes (P < 0.05) and an increase in catecholamine secretion rate from 38.7 +/- 6.0 ng/kg per 10 min to 180.0 +/- 40.0 after 70 minutes (P < 0.001). Catecholamines 264-277 renin Homo sapiens 113-118 7002344-5 1980 Intravenous infusion (0.4 microgram/kg per min) of an angiotensin II antagonist [Sar1, Ileu8]angiotensin II abolished the catecholamine response to intrarenal isoproterenol infusion. Catecholamines 122-135 angiotensinogen Homo sapiens 54-68 7002344-5 1980 Intravenous infusion (0.4 microgram/kg per min) of an angiotensin II antagonist [Sar1, Ileu8]angiotensin II abolished the catecholamine response to intrarenal isoproterenol infusion. Catecholamines 122-135 secretion associated Ras related GTPase 1A Homo sapiens 81-85 7002344-5 1980 Intravenous infusion (0.4 microgram/kg per min) of an angiotensin II antagonist [Sar1, Ileu8]angiotensin II abolished the catecholamine response to intrarenal isoproterenol infusion. Catecholamines 122-135 angiotensinogen Homo sapiens 93-107 6108354-2 1980 Determination of Mg2+ ATPase activity and catecholamines showed that the distribution of ATPase almost parallelled the distribution of catecholamines. Catecholamines 135-149 dynein axonemal heavy chain 8 Homo sapiens 89-95 7004910-1 1980 It has been established that the catecholamine-induced increase in renin secretion by juxtaglomerular apparatus cells and sodium reabsorption stimulation in the rat kidney are consequent on the excitation of renal beta-adrenoreceptors. Catecholamines 33-46 renin Rattus norvegicus 67-72 7010196-5 1980 There were also higher levels of urinary catecholamines in the high renin group of patients. Catecholamines 41-55 renin Homo sapiens 68-73 7441262-3 1980 We have examined the role of the AChE synthesized by the cells on ACh-evoked release of catecholamine from the cells. Catecholamines 88-101 acetylcholinesterase Bos taurus 33-37 7004910-3 1980 When given in a dose inhibiting angiotensin II formation and renin-secreting effect of catecholamines, heparin also diminishes their activating effect on tubular sodium transport. Catecholamines 87-101 renin Rattus norvegicus 61-66 7004910-4 1980 It is suggested that the renin-angiotensin system may be directly involved into the mechanism of catecholamine-stimulated sodium reabsorption by the rat kidney. Catecholamines 97-110 renin Rattus norvegicus 25-30 7230013-14 1980 It is concluded that the levels of DBH in adrenal effluent plasma is an unreliable index of catecholamine exocytosis in the conscious calf. Catecholamines 92-105 dopamine beta-hydroxylase Bos taurus 35-38 6107269-2 1980 In each of these species catecholamines exert pronounced effects on insulin and glucagon release from the pancreas. Catecholamines 25-39 insulin Canis lupus familiaris 68-75 7052550-0 1980 Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors. Catecholamines 43-56 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-144 7052550-1 1980 The effect of acute phenylethanolamine-N-methyltransferase (PNMT) inhibition on rat brain catecholamine concentrations was studied. Catecholamines 90-103 phenylethanolamine-N-methyltransferase Rattus norvegicus 60-64 6996898-7 1980 We conclude that CLON inhibits the catecholamine (but not the glucagon) rise during insulin-induced hypoglycemia. Catecholamines 35-48 insulin Homo sapiens 84-91 7452299-2 1980 Solubilized DBH was adsorbed from crude extracts on Concanavalin A-Sepharose (Con A-Sepharose), resulting in enrichment of the enzyme as well as removal of endogenous catecholamines and inhibitory substances. Catecholamines 167-181 dopamine beta-hydroxylase Bos taurus 12-15 6105069-0 1980 Somatostatin analog: plasma catecholamine suppression mediated by the central nervous system. Catecholamines 28-41 somatostatin Homo sapiens 0-12 6105069-1 1980 The somatostatin analog, des-AA1,2,4,5,12,13-[D-Trp8]somatostatin (ODT8-SS), acts within the central nervous system to suppress the rise in plasma catecholamines associated with a variety of neural stimuli. Catecholamines 147-161 somatostatin Homo sapiens 4-16 6105069-1 1980 The somatostatin analog, des-AA1,2,4,5,12,13-[D-Trp8]somatostatin (ODT8-SS), acts within the central nervous system to suppress the rise in plasma catecholamines associated with a variety of neural stimuli. Catecholamines 147-161 somatostatin Homo sapiens 53-65 6107928-6 1980 Regional studies by microdissection techniques in combination with a sensitive radioenzymatic catecholalmine assay, indicate that vasopressin modulates memory processes by modulation of neurotransmission in distinct catecholamine systems. Catecholamines 216-229 arginine vasopressin Homo sapiens 130-141 7206380-0 1980 Activation by phospholipase A2 of the catecholamine release from isolated chromaffin granules. Catecholamines 38-51 phospholipase A2 group IB Homo sapiens 14-30 6249456-4 1980 Tyrosine hydroxylase is needed for the conversion of tyrosine to dopamine (DA) and norpinephrine (NE); altering the level of this enzyme could affect catecholamine (CA) turnover. Catecholamines 150-163 tyrosine hydroxylase Homo sapiens 0-20 6107269-3 1980 In man, baboons, and rats catecholamine-induced alterations in pancreatic hormone release indirectly influence the hyperglycemic response to these amines: glucagon release supports and insulin release limits hyperglycemic responses. Catecholamines 26-39 insulin Canis lupus familiaris 185-192 7404186-1 1980 A method for the determination of catecholamines (Cat-a-Kit; Upjohn Diagnostics) is discussed. Catecholamines 34-48 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 56-59 7430898-6 1980 The inhibition of catecholamine synthesis by alpha-methyl-p-tyrosine blocked the secretory episode of GH following administration of GHB and after insulin hypoglycaemia whereas the GH rise induced by clonidine was unchanged. Catecholamines 18-31 gonadotropin releasing hormone receptor Rattus norvegicus 102-104 7430898-6 1980 The inhibition of catecholamine synthesis by alpha-methyl-p-tyrosine blocked the secretory episode of GH following administration of GHB and after insulin hypoglycaemia whereas the GH rise induced by clonidine was unchanged. Catecholamines 18-31 gonadotropin releasing hormone receptor Rattus norvegicus 133-135 6998757-0 1980 [Counterregulatory action of catecholamines on insulin-induced hypoglycemia in normal subjects and diabetics (author"s transl)]. Catecholamines 29-43 insulin Homo sapiens 47-54 7012405-0 1980 [Alteration in plasma catecholamines during insulin-induced hypoglycemia and cold pressure test in normal subjects and essential hypertension (author"s transl)]. Catecholamines 22-36 insulin Homo sapiens 44-51 6104663-0 1980 Tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells. Catecholamines 35-48 tyrosine hydroxylase Homo sapiens 0-24 6104663-9 1980 These results provide direct evidence that tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells and that incubation with 56 mM K+ or with cholera toxin causes the activation of this enzyme in these cells. Catecholamines 78-91 tyrosine hydroxylase Homo sapiens 43-67 7404186-2 1980 It depends upon the enzymatic conversion of the catecholamines to their ring o-methylated analogues in the presence of s-adenosyl-L-methionine-methyl-14C and catechol-o-methyltransferase. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 158-186 6102598-0 1980 Catecholamine modulation of enkephalin-induced electrophysiological responses in cerebral cortex. Catecholamines 0-13 proenkephalin Rattus norvegicus 28-38 7392663-2 1980 Catecholamines in sera or tissue homogenates were enzymatically O-methylated in the presence of partially purified catechol-O-methyltransferase with S-[methyl-3H] adenosyl methionine serving as the methyl donor. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 115-143 6993281-0 1980 Role of glucose and catecholamines in the regulation of insulin secretion in the hibernating hedgehog (Erinaceus europaeus) during arousal. Catecholamines 20-34 insulin Erinaceus europaeus 56-63 7417130-0 1980 Catecholamine excretion in A-10 pilots. Catecholamines 0-13 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 27-31 7417130-3 1980 Catecholamine excretion was significantly elevated (p < 0.05) over basal rates during all 11 training sorties; therefore, it was concluded that A-10 conversion and surface attack training results in a significant stress response in the subjects. Catecholamines 0-13 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 147-151 7002241-0 1980 Renin-angiotensin mediation of adrenal catecholamine secretion induced by hypoglycaemia in the cat. Catecholamines 39-52 renin Felis catus 0-5 7003689-1 1980 Relationships between changes in plasma water, electrolytes, insulin and catecholamines during attacks. Catecholamines 73-87 insulin Homo sapiens 61-68 7393972-0 1980 alpha-MSH effects on novelty-induced defecation, plasma 11-OHCS and whole brain catecholamines in hypophysectomized rats. Catecholamines 80-94 proopiomelanocortin Rattus norvegicus 0-9 7365003-0 1980 alpha-MSH- and novelty-induced emotional responses in rats: associated changes in plasma corticosterone and brain catecholamines. Catecholamines 114-128 proopiomelanocortin Rattus norvegicus 0-9 6930336-1 1980 Phenosulphotransferase (EC 2.8.2.1) (PST) is an important catecholamine and drug metabolizing enzyme. Catecholamines 58-71 sulfotransferase family 1A member 1 Homo sapiens 37-40 6786156-0 1980 Role of calmodulin in states of altered catecholamine sensitivity. Catecholamines 40-53 calmodulin 1 Homo sapiens 8-18 6101988-0 1980 Catecholamine-stimulated cyclic AMP formation in phenylethanolamine N-methyltransferase containing brain stem nuclei of normal rats and of rats with spontaneous genetic hypertension. Catecholamines 0-13 phenylethanolamine-N-methyltransferase Rattus norvegicus 49-87 6989415-8 1980 A relationship was established between SAS and HAS as well as between insulin and catecholamine content under physical and emotional exposures. Catecholamines 82-95 INS Equus caballus 70-77 7366740-3 1980 Its essential features are: a saturable uptake process (uptake 2), a saturable, intracompartmental enzyme (COMT), the ability of the catecholamine to penetrate the membrane of the model compartment by a diffusional flux obeying first-order kinetics, and the ability of the metabolite to leave the compartment by an efflux obeying first-order kinetics. Catecholamines 133-146 catechol-O-methyltransferase Rattus norvegicus 107-111 6153144-7 1980 Thus, catecholamines may participate in the regulation of ornithine decarboxylase activity in the ovary. Catecholamines 6-20 ornithine decarboxylase 1 Homo sapiens 58-81 6153144-8 1980 Catecholamine effects may be mediated by beta-2-receptors linked to the adenylate cyclase system. Catecholamines 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 41-47 6246737-0 1980 Effect of calmodulin on catecholamine-linked adenylate cyclase activity in rat striatum and cerebral cortex. Catecholamines 24-37 calmodulin 1 Rattus norvegicus 10-20 6771065-3 1980 Inhibition of endogenous catecholamine reuptake by nomifensine significantly inhibited prolactin release whereas it had no effect on TSH and GH levels. Catecholamines 25-38 prolactin Homo sapiens 87-96 6987903-0 1980 Preservation of left ventricular function by insulin in experimental catecholamine cardiomyopathy. Catecholamines 69-82 insulin Oryctolagus cuniculus 45-52 6986474-7 1980 The mechanism directing elevated renin secretion may be related to changes in regional blood flow in addition to the stimulus of increased catecholamine activity. Catecholamines 139-152 renin Homo sapiens 33-38 7001835-3 1980 Regarding metabolic functions we found normal responses to graded exercise and insulin-induced hypoglycemia in patients with autonomic neuropathy in spite of blunted catecholamine responses, suggesting increased sensitivity of glycogen stores and adipose tissue towards the action of catecholamine in patients with autonomic neuropathy. Catecholamines 284-297 insulin Homo sapiens 79-86 7418541-3 1980 The main purpose of the study was to find out how a reduction or an increase of total body sodium and the associated changes of renin production can influence the vascular response to angiotensin and to catecholamines. Catecholamines 203-217 renin Rattus norvegicus 128-133 6248019-6 1980 It is concluded that the positive inotropic effect of catecholamines may be mediated by the described actions of intracellular Ca++ and c-AMP upon the contractile structures where c-AMP-dependent troponin phosphorylation could account for the acceleration of relaxation. Catecholamines 54-68 cathelicidin antimicrobial peptide Homo sapiens 136-141 6248019-6 1980 It is concluded that the positive inotropic effect of catecholamines may be mediated by the described actions of intracellular Ca++ and c-AMP upon the contractile structures where c-AMP-dependent troponin phosphorylation could account for the acceleration of relaxation. Catecholamines 54-68 cathelicidin antimicrobial peptide Homo sapiens 180-185 497858-4 1979 The acute pressor responses produced by intraventricular injections of AII and carbachol were virtually abolished by central catecholamine depletion. Catecholamines 125-138 angiotensinogen Rattus norvegicus 71-74 6110219-0 1980 Thyrotropin releasing hormone: neurochemical evidence for the potentiation of imipramine effects on the metabolism and uptake of brain catecholamines. Catecholamines 135-149 thyrotropin releasing hormone Homo sapiens 0-29 230943-0 1979 Control of gastrin secretion by catecholamines with special reference to duodenal ulcer. Catecholamines 32-46 gastrin Homo sapiens 11-18 230036-0 1979 The stimulation of the mitochondrial uncoupler-dependent ATPase in isolated hepatocytes by catecholamines and glucagon and its relationship to gluconeogenesis. Catecholamines 91-105 dynein axonemal heavy chain 8 Homo sapiens 57-63 500827-0 1979 Effect of central catecholamine depletion on the osmotic and nonosmotic stimulation of vasopressin (antidiuretic hormone) in the rat. Catecholamines 18-31 arginine vasopressin Rattus norvegicus 87-98 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 64-89 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 91-94 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 phenylethanolamine-N-methyltransferase Rattus norvegicus 99-137 530533-2 1979 The catecholamine (CA) levels were measured after inhibition of dopamine-beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 4-17 phenylethanolamine-N-methyltransferase Rattus norvegicus 139-143 6767993-5 1980 L-Dopa blocked the increase produced by TRH, but this effect could be reversed by pretreatment with carbidopa, an inhibitor of the conversion of L-dopa to catecholamines outside the blood-brain barrier. Catecholamines 155-169 TRH Canis lupus familiaris 40-43 487159-10 1979 Modulation of catecholamine turnover in specific brain areas after AVP administration may be related to this behavioral effect. Catecholamines 14-27 arginine vasopressin Rattus norvegicus 67-70 391685-2 1979 Their actions are best understood by an appreciation of the relative ability of each catecholamine to activate alpha, beta 1 and beta 2 adrenergic receptors in the myocardium and peripheral vasculature. Catecholamines 85-98 adrenoceptor beta 1 Homo sapiens 111-156 41665-7 1979 Catecholamines activated adenylate cyclase 2.5- to three-fold, with an order of potency (protokylol greater than isoprenaline greater than adrenaline greater than noradrenaline) typical of a beta 2-adrenoreceptor. Catecholamines 0-14 adenylate cyclase 2 Homo sapiens 25-44 464113-3 1979 36: 582-593, 1969) that in the rabbit aorta, desoxycorticosterone (DOC) potentiates the contractile response to certain catecholamines by inhibiting their degradation by catechol-O-methyltransferase. Catecholamines 120-134 catechol O-methyltransferase Oryctolagus cuniculus 170-198 116225-2 1979 The inhibition is reversed by citrate, 3-phosphoglycerate, malate, phosphate, and catecholamines, all of which have previously been described as activators of hexokinase at low pH. Catecholamines 82-96 hexokinase Saccharomyces cerevisiae S288C 159-169 396489-1 1979 Relationship between renin, aldosterone, catecholamines and prolactin]. Catecholamines 41-55 prolactin Homo sapiens 60-69 537272-0 1979 Effects of angiotensin II on the medullary neurons and their sensitivity to acetylcholine and catecholamines. Catecholamines 94-108 angiotensinogen Homo sapiens 11-25 110623-6 1979 Regional studies, utilizing microdissection techniques in combination with a sensitive radioenzymatic catecholamine assay, revealed a distinct pattern of effects on cerebral alpha-methyl-p-tyrosine methylester-induced catecholamine disappearance following intraventricular vasopressin administration in limbic midbrain structures. Catecholamines 218-231 arginine vasopressin Rattus norvegicus 273-284 110623-8 1979 These results indicate that vasopressin modulates memory processes by modulation of neurotransmission in distinct catecholamine systems. Catecholamines 114-127 arginine vasopressin Rattus norvegicus 28-39 443969-3 1979 Since thyroid hormone can increase tissue responsiveness to catecholamines, and since catecholamines can stimulate PTH secretion, we postulate that the elevated levels of PTH were secondary to thyrotoxicosis. Catecholamines 60-74 parathyroid hormone Homo sapiens 171-174 443969-3 1979 Since thyroid hormone can increase tissue responsiveness to catecholamines, and since catecholamines can stimulate PTH secretion, we postulate that the elevated levels of PTH were secondary to thyrotoxicosis. Catecholamines 86-100 parathyroid hormone Homo sapiens 115-118 443969-3 1979 Since thyroid hormone can increase tissue responsiveness to catecholamines, and since catecholamines can stimulate PTH secretion, we postulate that the elevated levels of PTH were secondary to thyrotoxicosis. Catecholamines 86-100 parathyroid hormone Homo sapiens 171-174 225615-0 1979 Rapid rise in cyclic GMP accompanies catecholamine secretion in suspensions of isolated adrenal chromaffin cells. Catecholamines 37-50 5'-nucleotidase, cytosolic II Homo sapiens 21-24 508416-0 1979 [Effects of catecholamine treatment on UDPG levels in white and red skeletal muscle]. Catecholamines 12-25 UDP-glucose pyrophosphorylase 2 Homo sapiens 39-43 157829-7 1979 A significant increase in catecholamine concentration was observed in the ventricles of rats treated with Sar1,Ile8-AII and Sar1,Ala8-AII but no change was found in the group treated with the Sar1,Thr8-AII analogue. Catecholamines 26-39 angiotensinogen Rattus norvegicus 116-119 157829-7 1979 A significant increase in catecholamine concentration was observed in the ventricles of rats treated with Sar1,Ile8-AII and Sar1,Ala8-AII but no change was found in the group treated with the Sar1,Thr8-AII analogue. Catecholamines 26-39 angiotensinogen Rattus norvegicus 134-137 157829-7 1979 A significant increase in catecholamine concentration was observed in the ventricles of rats treated with Sar1,Ile8-AII and Sar1,Ala8-AII but no change was found in the group treated with the Sar1,Thr8-AII analogue. Catecholamines 26-39 angiotensinogen Rattus norvegicus 134-137 157829-8 1979 The production of cardiac hypertrophy by Sar1,Ile8-AII was prevented by bilateral adrenalectomy, suggesting an important role for catecholamines in modulating cardiac hypertrophy. Catecholamines 130-144 angiotensinogen Rattus norvegicus 51-54 458440-1 1979 Knowledge of the vesicular origin of circulating dopamine beta-hydroxylase (DbetaH) is indispensable for any attempts to explain the parallelism or lack of it between circulating enzyme and catecholamines as they may relate to physiological stress, forms of hypertension, neurological disorders, and the response to pharmacological agents. Catecholamines 190-204 dopamine beta-hydroxylase Rattus norvegicus 49-74 458440-1 1979 Knowledge of the vesicular origin of circulating dopamine beta-hydroxylase (DbetaH) is indispensable for any attempts to explain the parallelism or lack of it between circulating enzyme and catecholamines as they may relate to physiological stress, forms of hypertension, neurological disorders, and the response to pharmacological agents. Catecholamines 190-204 dopamine beta-hydroxylase Rattus norvegicus 76-82 35506-1 1979 The PAP unlabelled antibody enzyme method of Sternberger was used for the histochemical demonstration of LHRH and the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH) in the hypothalamus of the adult male and pregnant female rat. Catecholamines 118-131 tyrosine hydroxylase Rattus norvegicus 153-173 475568-3 1979 However, marked elevations of serum dopamine-beta-hydroxylase (DBH) accompanied by relatively slight elevations of plasma catecholamines are observed during hypertensive paroxysms in patients with autonomic hyperreflexia, while marked elevations of plasma catecholamines with little if any change in serum DBH concentration are characteristic of hypertensive paroxysms caused by pheochromocytoma. Catecholamines 256-270 dopamine beta-hydroxylase Homo sapiens 63-66 35506-1 1979 The PAP unlabelled antibody enzyme method of Sternberger was used for the histochemical demonstration of LHRH and the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH) in the hypothalamus of the adult male and pregnant female rat. Catecholamines 118-131 tyrosine hydroxylase Rattus norvegicus 175-177 421548-9 1979 Thus, the effects of catecholamines on parameters of myocardial contractility (PEPc, PEP/LVET) were presumably offset by the increased afterload. Catecholamines 21-35 peptidase C Homo sapiens 79-83 369634-4 1979 Resection of the corporo-caudal part of the pancreas intensified the pressor reactions to noradrenaline, and depressor ones to bradykinin and kallikrein; it increased the initial negative chronotropic effect of catecholamines on the heart, and also enhanced the positive chronotropic effect of noradrenaline, kallikrein and bradykinin on the heart. Catecholamines 211-225 kininogen 1 Canis lupus familiaris 324-334 546488-2 1979 The Km values, which reflect the affinity of substrate and enzyme, show that RL COMT has the highest affinity toward the catecholamine substrates followed by HP COMT and then HL COMT. Catecholamines 121-134 catechol-O-methyltransferase Homo sapiens 80-84 546488-2 1979 The Km values, which reflect the affinity of substrate and enzyme, show that RL COMT has the highest affinity toward the catecholamine substrates followed by HP COMT and then HL COMT. Catecholamines 121-134 catechol-O-methyltransferase Homo sapiens 161-165 546488-2 1979 The Km values, which reflect the affinity of substrate and enzyme, show that RL COMT has the highest affinity toward the catecholamine substrates followed by HP COMT and then HL COMT. Catecholamines 121-134 catechol-O-methyltransferase Homo sapiens 161-165 421548-9 1979 Thus, the effects of catecholamines on parameters of myocardial contractility (PEPc, PEP/LVET) were presumably offset by the increased afterload. Catecholamines 21-35 progestagen associated endometrial protein Homo sapiens 79-82 546488-3 1979 Both HP and RL COMT preparations O-methylate the catecholamines primarily in the meta position. Catecholamines 49-63 catechol-O-methyltransferase Homo sapiens 15-19 219400-0 1979 Vasopressin modulates the activity of catecholamine containing neurons in specific brain regions. Catecholamines 38-51 arginine vasopressin Rattus norvegicus 0-11 372694-0 1979 [A study of the alveolar-arterial oxygen gradients and intrapulmonary shunt under the action of NAB-365, a new exogenous catecholamine of selective beta-2 action (author"s transl)]. Catecholamines 121-134 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 148-154 478387-1 1979 The effect of insulin on blood phenylalanine, tyrosine and catecholamine levels was investigated in six phenylketonuric patients and eight normal controls. Catecholamines 59-72 insulin Homo sapiens 14-21 478387-6 1979 It appeared that insulin treatment produced some therapeutic effects in patients with smaller phenylalanine-tyrosine ratios or elevated catecholamine levels. Catecholamines 136-149 insulin Homo sapiens 17-24 34116-2 1979 Depletion of brain catecholamine stores increased Prl and decreased LH levels while GH secretion was not affected. Catecholamines 19-32 prolactin Rattus norvegicus 50-53 34116-6 1979 Depletion of brain catecholamine stores or blockade of beta-adrenergic receptors antagonized the restraint-induced rise of plasma Prl values, while the decrease of GH elicited by stress was not modified by any pharmacological manipulation. Catecholamines 19-32 prolactin Rattus norvegicus 130-133 437482-0 1979 Activating effect of copper ions on the interaction of ceruloplasmin with catecholamines. Catecholamines 74-88 ceruloplasmin Homo sapiens 55-68 215749-7 1979 A significant decrease in the sensitivity of synaptosomal ATPase to catecholamines was observed in mice rendered tolerant by morphine pellet implantation. Catecholamines 68-82 dynein, axonemal, heavy chain 8 Mus musculus 58-64 215749-11 1979 These results suggest that in mouse brain synaptosomes morphine may be interacting with ATPase at or near the catecholamine-active sites. Catecholamines 110-123 dynein, axonemal, heavy chain 8 Mus musculus 88-94 219400-5 1979 The results support the hypothesis that vasopressin modulates catecholamine neurotransmission in specific brain regions of the rat. Catecholamines 62-75 arginine vasopressin Rattus norvegicus 40-51 370967-5 1979 We conclude that the carotid baroreceptors can influence the gastrin release by a reflex adjustment of the release of adrenal catecholamines. Catecholamines 126-140 LOC105260099 Felis catus 61-68 538080-3 1979 In order to learn whether p-hydroxyamphetamine can be further metabolized to a catecholamine, a sensitive radioenzymatic assay was developed which couples the formation of the "catecholamphetamine" to rapid O-methylation by catechol-O-methyltransferase in the presence of [3H]-methyl-S-adenosylmethionine. Catecholamines 79-92 catechol-O-methyltransferase Rattus norvegicus 224-252 744568-6 1978 A modulation of catecholamine release appears to be of importance in the mode of action of alrestatin with respect to the insulin secretion and plasma glucose levels. Catecholamines 16-29 insulin Homo sapiens 122-129 729647-0 1978 Angiotensin II mediation of adrenal catecholamine secretion induced by intrarenal isoprenaline infusion. Catecholamines 36-49 angiotensinogen Homo sapiens 0-14 744179-2 1978 It is concluded that in situations in which an increase of vasopressin release is expected, the posterior pituitary content of catecholamines will also be increased, and vice versa, which might imply their role in the release of vasopressin. Catecholamines 127-141 arginine vasopressin Rattus norvegicus 229-240 748009-0 1978 Catecholamine concentration and turnover in discrete regions of the brain of the homozygous Brattleboro rat deficient in vasopressin. Catecholamines 0-13 arginine vasopressin Rattus norvegicus 121-132 727879-4 1978 We now report that further biochemical discrimination among depressive subtypes is provided by the following equation, derived empirically by applying multivariate discriminant function analysis to data on urinary catecholamine metabolits: Depression-type (D-type) score = C1(MHPG) + C2(VMA) + C3(NE) +C4(NMN + MN)/VMA + C0. Catecholamines 214-227 complement C2 Homo sapiens 284-291 727879-4 1978 We now report that further biochemical discrimination among depressive subtypes is provided by the following equation, derived empirically by applying multivariate discriminant function analysis to data on urinary catecholamine metabolits: Depression-type (D-type) score = C1(MHPG) + C2(VMA) + C3(NE) +C4(NMN + MN)/VMA + C0. Catecholamines 214-227 complement C2 Homo sapiens 287-290 211986-9 1978 Although catecholamines are involved in growth hormone (GH) and cortisol regulation, no abnormalities were found in GH or cortisol levels. Catecholamines 9-23 growth hormone 1 Homo sapiens 40-54 724670-0 1978 [Dynamics of levels of growth hormone and free fatty acids in the blood, and catecholamines in the urine of insulin-resistant and insulin-sensitive diabetes mellitus patients during insulin hypoglycemia]. Catecholamines 77-91 insulin Homo sapiens 108-115 724670-1 1978 The changes in the content of STH and FFA in the blood and of catecholamines in the urine under the effect of insulin hypoglycemia were studied in 28 insulin-sensitive and 40 insulin-resistant patients suffering from diabetes mellitus. Catecholamines 62-76 insulin Homo sapiens 110-117 724670-5 1978 It is suggested that in the insulin-resistant patients, due to reduction of the STH and catecholamine stimuli, FFA is incapable of providing the necessary energy balance at the cellular level in insulin insufficiency. Catecholamines 88-101 insulin Homo sapiens 28-35 724670-7 1978 Reduction of the FFA and catecholamine reserves in the insulin-resistant patients suffering from diabetes mellitus is postulated to be one of the main factors in the resistance pathogenesis. Catecholamines 25-38 insulin Homo sapiens 55-62 211986-9 1978 Although catecholamines are involved in growth hormone (GH) and cortisol regulation, no abnormalities were found in GH or cortisol levels. Catecholamines 9-23 growth hormone 1 Homo sapiens 56-58 677197-1 1978 Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 0-28 28664-6 1978 Of these, an increase in insulin antagonistic hormones; among them growth hormone, catecholamines, and glucagon, seems to be of most significance. Catecholamines 83-97 insulin Homo sapiens 25-32 361531-0 1978 Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: effects of somatostatin. Catecholamines 0-13 insulin Oryctolagus cuniculus 62-69 361531-0 1978 Catecholamine-induced changes in plasma glucose, glucagon and insulin in rabbits: effects of somatostatin. Catecholamines 0-13 somatostatin Oryctolagus cuniculus 93-105 570403-4 1978 It is concluded that PLP enhances the response of coronary smooth muscle to adrenaline by inhibiting a enzymatic pathway for the inactivation of catecholamines. Catecholamines 145-159 proteolipid protein 1 Homo sapiens 21-24 677197-1 1978 Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 30-34 673021-0 1978 Inhibitory effect of tyramine-induced release of catecholamines on renin secretion. Catecholamines 49-63 renin Rattus norvegicus 67-72 28554-1 1978 Intraventricular 6-OHDA treatment to newborn rats produced a marked reduction in tyrosine hydroxylase activity in most brain regions at maturity which correlated moderately well with the catecholamine levels. Catecholamines 187-200 tyrosine hydroxylase Rattus norvegicus 81-101 660556-9 1978 The data suggest that 1) a major portion of total PH4 (as much as 90% in the striatum) is related to the function of catecholaminergic rather than serotonergic systems, 2) PH4 levels is a determinant of the velocity of DA synthesis and 3) PH4 levels are altered by some psychoactive drugs in association with changes in synaptosomal catecholamine biosynthetic rates. Catecholamines 117-130 prolyl 4-hydroxylase, transmembrane Rattus norvegicus 50-53 660556-9 1978 The data suggest that 1) a major portion of total PH4 (as much as 90% in the striatum) is related to the function of catecholaminergic rather than serotonergic systems, 2) PH4 levels is a determinant of the velocity of DA synthesis and 3) PH4 levels are altered by some psychoactive drugs in association with changes in synaptosomal catecholamine biosynthetic rates. Catecholamines 117-130 prolyl 4-hydroxylase, transmembrane Rattus norvegicus 172-175 660556-9 1978 The data suggest that 1) a major portion of total PH4 (as much as 90% in the striatum) is related to the function of catecholaminergic rather than serotonergic systems, 2) PH4 levels is a determinant of the velocity of DA synthesis and 3) PH4 levels are altered by some psychoactive drugs in association with changes in synaptosomal catecholamine biosynthetic rates. Catecholamines 117-130 prolyl 4-hydroxylase, transmembrane Rattus norvegicus 172-175 673021-6 1978 It is concluded that catecholamines which are released from renal sympathetic nerve endings can suppress renin release by activating alpha-adrenoceptors. Catecholamines 21-35 renin Rattus norvegicus 105-110 45520-11 1978 The results are compatible with the hypothesis that catecholamines act via receptors and formation of cAMP. Catecholamines 52-66 cathelicidin-7 Bos taurus 102-106 208077-7 1978 Prostaglandin E(1) and catecholamines stimulated cAMP production but were 1/2.3 and 1/5.5 as efficient as VIP, respectively. Catecholamines 23-37 vasoactive intestinal peptide Homo sapiens 106-109 206158-7 1978 The results suggest that the time course of cAMP-dependent protein kinase activation is appropriate if this enzyme is to play a role in the catecholamine-induced increase in both glycogenolysis and contractility in the in vivo heart. Catecholamines 140-153 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 59-73 96471-0 1978 A twin study on three enzymes (DBH, COMT, MAO) of catecholamine metabolism. Catecholamines 50-63 dopamine beta-hydroxylase Homo sapiens 31-34 96135-0 1978 Parathyroid hormone responses to catecholamines and to changes of extracellular calcium in cows. Catecholamines 33-47 parathyroid hormone Bos taurus 0-19 96471-0 1978 A twin study on three enzymes (DBH, COMT, MAO) of catecholamine metabolism. Catecholamines 50-63 catechol-O-methyltransferase Homo sapiens 36-40 633087-7 1978 These data suggest that the liberation of catecholamines may account, in part, for the minimal increases in forelimb protein efflux during systemic infusions of bradykinin relative to that produced by local intra-arterial infusions of this agent. Catecholamines 42-56 kininogen 1 Canis lupus familiaris 161-171 639332-7 1978 Many factors may be involved in the increased activation of the renin-angiotensin-aldosterone system: low blood pressure, hypersensitivity of the macula densa to catecholamines, relative insensitivity of the immature kidney to aldosterone, hyperkalaemia and other control mechanisms for aldosterone secretion all of which probably operate simultaneously during the first days of life. Catecholamines 162-176 renin Homo sapiens 64-69 634141-0 1978 Effect of catecholamines on gastrin release. Catecholamines 10-24 gastrin Rattus norvegicus 28-35 634141-1 1978 In vivo and in vitro techniques have been used to study the effect of catecholamines on gastrin release. Catecholamines 70-84 gastrin Rattus norvegicus 88-95 23469-5 1978 The activity of adrenal catecholamine-synthesizing enzymes also increased with age: tyrosine hydroxylase gradually increased until the 360th day, dopamine-beta-hydroxylase and phenylethanolamine-N-methyl transferase until the 200th day. Catecholamines 24-37 dopamine beta-hydroxylase Rattus norvegicus 146-171 210258-0 1978 Short-term regulation of catecholamine biosynthesis in a nerve growth factor responsive clonal line of rat pheochromocytoma cells. Catecholamines 25-38 nerve growth factor Rattus norvegicus 57-76 215928-9 1978 These data indicate that sodium deprivation enhances the sensitivity of the renin-secreting cells to catecholamine stimulation, and are consistent with the hypothesis that the increase in renin secretion produced by NE is mediated via cyclic AMP. Catecholamines 101-114 renin Rattus norvegicus 76-81 623944-5 1978 Further data correlating COMT assays with catecholamine metabolites in depressed patients may reveal homogeneous biochemical subgroups which could serve as a guide to rational therapy. Catecholamines 42-55 catechol-O-methyltransferase Homo sapiens 25-29 627826-0 1978 Effects of inhibitors of catecholamine synthesis and catecholamine agonists on morphine- and hypoglycaemia-induced release of growth hormone in the rat. Catecholamines 25-38 gonadotropin releasing hormone receptor Rattus norvegicus 126-140 627826-0 1978 Effects of inhibitors of catecholamine synthesis and catecholamine agonists on morphine- and hypoglycaemia-induced release of growth hormone in the rat. Catecholamines 53-66 gonadotropin releasing hormone receptor Rattus norvegicus 126-140 749914-23 1978 Catecholamines, in contrast, have their most potent effects on adipose tissue, stimulating lipolysis and fatty acid release even in the presence of insulin. Catecholamines 0-14 insulin Homo sapiens 148-155 624999-13 1978 These findings provide further support for the view that the process of catecholamine-induced renin secretion involves mobilization of Ca from a cellular site. Catecholamines 72-85 renin Homo sapiens 94-99 285022-2 1978 DBH is a catecholamine biosynthetic enzyme and COMT is catecholamine metabolic enzyme. Catecholamines 9-22 dopamine beta-hydroxylase Homo sapiens 0-3 285022-2 1978 DBH is a catecholamine biosynthetic enzyme and COMT is catecholamine metabolic enzyme. Catecholamines 55-68 dopamine beta-hydroxylase Homo sapiens 0-3 285022-2 1978 DBH is a catecholamine biosynthetic enzyme and COMT is catecholamine metabolic enzyme. Catecholamines 55-68 catechol-O-methyltransferase Homo sapiens 47-51 925075-6 1977 Neuronal differentiation examined by measuring catecholamine (CA) production from tyrosine also depended on the level of NGF in the culture medium. Catecholamines 47-60 nerve growth factor Rattus norvegicus 121-124 645318-3 1978 B6) in the treatment of depressive states, inasmuch as it is involved in the process of catecholamine synthesis as a cofactor of DOPA-decarboxylase. Catecholamines 88-101 dopa decarboxylase Homo sapiens 129-147 606891-6 1977 Serum DBH reflecting catecholamine also showed no significant change during the cooling or rewarming periods. Catecholamines 21-34 dopamine beta-hydroxylase Homo sapiens 6-9 589478-4 1977 Epinephrine levels are markedly increased in ganglia of NGF-treated rats younger than one week of age, but at older ages the levels of the catecholamine are only slightly greater than the controls. Catecholamines 139-152 nerve growth factor Rattus norvegicus 56-59 201940-4 1977 Finally, in Experiment 3, the three DBH inhibitors reduced self-stimulation (a behavior dependent upon catecholamines) in a dose-related manner and intraventricular injections of 1-norepinephrine reinstated normal rates of self-stimulation. Catecholamines 103-117 dopamine beta-hydroxylase Rattus norvegicus 36-39 925076-8 1977 The ability of neurons to produce catecholamine (CA) increased dramatically during the second and third weeks in both concentrations of NGF, and along a similar time-course, although neurons in submaximal NGF developed a lesser capacity for CA production. Catecholamines 34-47 nerve growth factor Rattus norvegicus 136-139 925077-8 1977 In mixed neuron-heart cell cultures, NGF increased both ACh and catecholamine (CA) production per neuron to the same extent; saturation occurred at 1 microgram/ml 7S NGF. Catecholamines 64-77 nerve growth factor Rattus norvegicus 37-40 411377-4 1977 The relatively low effective doses of TRH used to suppress the DA-induced GH increase suggest an interaction with catecholamines at the hypothalamic and/or pituitary to influence GH release. Catecholamines 114-128 thyrotropin releasing hormone Papio anubis 38-41 589439-2 1977 These cells were used because, like sympathetic neurons, they synthesize large amounts of noradrenaline in the presence of ascorbate, they respond to nerve growth factor with the production of neurites and they release, store and take up catecholamines. Catecholamines 238-252 nerve growth factor Rattus norvegicus 150-169 29549-0 1977 Catecholamines: effects of ACTH and adrenal corticoids. Catecholamines 0-14 proopiomelanocortin Homo sapiens 27-31 563424-0 1977 Changes in catecholamine content of the median eminence precede the pro-oestrous surges of luteinizing hormone and prolactin. Catecholamines 11-24 prolactin Homo sapiens 115-124 29551-0 1977 Neurotransmitters involved in ACTH secretion: catecholamines. Catecholamines 46-60 proopiomelanocortin Homo sapiens 30-34 410420-0 1977 Thyrotropin-releasing hormone--increased catabolism of catecholamines in brains of thyroidectomized rats. Catecholamines 55-69 thyrotropin releasing hormone Rattus norvegicus 0-29 336417-5 1977 Consequently, the catecholamines activate primarily the release and then the synthesis of Gn-RH. Catecholamines 18-32 gonadotropin releasing hormone 1 Homo sapiens 90-95 885164-0 1977 Renin-angiotensin mediation of adrenal catecholamine secretion induced by haemorrhage. Catecholamines 39-52 renin Felis catus 0-5 337754-5 1977 There was no proliferation of B cells, but a retention of B cell granules, a manifestation of suppressed secretion of insulin attributed to the overproduction of catecholamines was evident. Catecholamines 162-176 insulin Homo sapiens 118-125 20213-4 1977 While in the hypothyroid animals at 4 degrees C the concentration of adrenal catecholamines was less, the epinephrine to norepinephrine ratio was higher than at 23 degrees C. Very high TH activity with a decline in catecholamine concentration suggests that the capacity of TH had been exceeded. Catecholamines 77-91 tyrosine hydroxylase Rattus norvegicus 185-187 20213-4 1977 While in the hypothyroid animals at 4 degrees C the concentration of adrenal catecholamines was less, the epinephrine to norepinephrine ratio was higher than at 23 degrees C. Very high TH activity with a decline in catecholamine concentration suggests that the capacity of TH had been exceeded. Catecholamines 77-90 tyrosine hydroxylase Rattus norvegicus 185-187 199532-4 1977 In these investigations it has been tested to see whether the catecholamines released by this activation modulate renin release by stimulation of certain alpha-receptors. Catecholamines 62-76 renin Rattus norvegicus 114-119 199532-8 1977 It is concluded that catecholamines released from the sympathetic nervous system can decrease renin secretion by an activation of certain alpha-receptors. Catecholamines 21-35 renin Rattus norvegicus 94-99 908179-4 1977 After removal of the tumour, the plasma dopamine-beta-hydroxylase activities in both patients gradually decreased to reach a stable value in correlation with urinary, excreted catecholamine levels. Catecholamines 176-189 dopamine beta-hydroxylase Homo sapiens 40-65 560237-0 1977 Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheo-chromocytoma cells. Catecholamines 31-45 nerve growth factor Homo sapiens 71-90 560237-0 1977 Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheo-chromocytoma cells. Catecholamines 31-45 nerve growth factor Homo sapiens 92-95 890120-3 1977 There are two possible mechanisms by which catecholamines synthesized in the LC cells could reach the blood; 1) through the cell membrane and then through the basal membrane of the capillary bed and the cytoplasm of the endothelial cell; 2) by virtue of the glia cells. Catecholamines 43-57 carboxyl ester lipase pseudogene Homo sapiens 232-239 874815-12 1977 These data suggest that catecholamines formed within the central nervous system can act to lower renin secretion as well as blood pressure. Catecholamines 24-38 renin Canis lupus familiaris 97-102 324754-5 1977 The VMH medium retained these activities even after oxidation with K3Fe (CN)6, whereas the ability of the catecholamines to inhibit insulin release and stimulate glucagon release was eliminated by this treatment. Catecholamines 106-120 insulin Homo sapiens 132-139 18555-0 1977 Tyrosine hydroxylase activity in the catecholamine nerve terminals and cell bodies of the rat brain. Catecholamines 37-50 tyrosine hydroxylase Rattus norvegicus 0-20 882717-0 1977 [The influence of catecholamines and sekretin on the serum-gastrin-concentration in rabbits (author"s transl)]. Catecholamines 18-32 gastrin Oryctolagus cuniculus 59-66 905266-5 1977 Oxidative catecholamine deamination was enhanced under the effect of hydrocortisone; it was prevented by prescription of nuredal, a MAO inhibitor. Catecholamines 10-23 monoamine oxidase A Rattus norvegicus 132-135 882717-5 1977 The gastrin secretion pattern in rabbits influenced by catecholamines and secretin is in complete contrast to human conditions. Catecholamines 55-69 gastrin Oryctolagus cuniculus 4-11 884603-6 1977 272, 265-276), we have measured the activity of catechol O-methyltransferase (COMT) (EC 2.1.1.6) in red blood cells (RBC) of patients with hyperthyroidism and hypothyroidism to establish whether thyroid dysfunction is associated with alterations in catecholamine catabolism. Catecholamines 249-262 catechol-O-methyltransferase Homo sapiens 48-76 884603-6 1977 272, 265-276), we have measured the activity of catechol O-methyltransferase (COMT) (EC 2.1.1.6) in red blood cells (RBC) of patients with hyperthyroidism and hypothyroidism to establish whether thyroid dysfunction is associated with alterations in catecholamine catabolism. Catecholamines 249-262 catechol-O-methyltransferase Homo sapiens 78-82 839844-5 1977 Suppression of insulin secretion during perfusion may be the result of increased catecholamine secretion, induced hypothermia, or heparin administration. Catecholamines 81-94 insulin Homo sapiens 15-22 865132-1 1977 We found increased levels of catecholamines in some patients who had high-renin hypertension. Catecholamines 29-43 renin Homo sapiens 74-79 865133-2 1977 DBH is a catecholamine biosynthetic enzyme that is localized to catecholamine-containing vesicles, is released with catecholamines from sympathetic nerves and the adrenal medulla, and is found in serum. Catecholamines 9-22 dopamine beta-hydroxylase Homo sapiens 0-3 865133-2 1977 DBH is a catecholamine biosynthetic enzyme that is localized to catecholamine-containing vesicles, is released with catecholamines from sympathetic nerves and the adrenal medulla, and is found in serum. Catecholamines 64-77 dopamine beta-hydroxylase Homo sapiens 0-3 865133-2 1977 DBH is a catecholamine biosynthetic enzyme that is localized to catecholamine-containing vesicles, is released with catecholamines from sympathetic nerves and the adrenal medulla, and is found in serum. Catecholamines 116-130 dopamine beta-hydroxylase Homo sapiens 0-3 19556183-0 1977 Regional effects of vasopressin on rat brain catecholamine metabolism. Catecholamines 45-58 arginine vasopressin Rattus norvegicus 20-31 856615-4 1977 [Ile8]-angiotensin I blocked angiotensin II-induced catecholamine secretion and a pA2 value of 8.50 was obtained. Catecholamines 52-65 angiotensinogen Homo sapiens 29-43 876399-0 1977 The effects of an inhibitor of phenylethanolamine N-methyltransferase upon stimulated adrenal catecholamine release and excretion in the rat. Catecholamines 94-107 phenylethanolamine-N-methyltransferase Rattus norvegicus 31-69 19604975-0 1977 On the catecholamine control of growth hormone regulation. Catecholamines 7-20 gonadotropin releasing hormone receptor Rattus norvegicus 32-46 880178-4 1977 When catecholamine excretion data were interpreted for psychological significance, it was concluded that the lesson unit which included Power-on Stalls and Spin-Recoveries created the highest arousal, anxiety and apprehension. Catecholamines 5-18 spindlin 1 Homo sapiens 156-160 196270-0 1977 Catecholamine turnover measurement and ACTH-induced short-term changes of catecholamine levels in individual brain nuclei. Catecholamines 74-87 proopiomelanocortin Homo sapiens 39-43 196270-1 1977 The effect of acute ACTH treatment on catecholamine content of various brain nuclei was followed by radioenzymatic assay. Catecholamines 38-51 proopiomelanocortin Homo sapiens 20-24 833015-6 1977 When the acetylcholinesterase (AChE) reaction was performed subsequently to the GIF reaction the following nerve types could be identified: 1. nerves containing both catecholamine (CA) fluorescence and AChE, 2. Catecholamines 166-179 acetylcholinesterase Rattus norvegicus 31-35 16463-6 1977 We conclude that the release of catecholamines by these histamine H2-receptor antagonists is probably due to their cationic (imidazolium) forms. Catecholamines 32-46 histamine receptor H 2 Rattus norvegicus 56-77 319936-2 1977 There was also a significant reduction in plasma dopamine beta-hydroxylase activity during fenfluramine treatment, suggesting that chronic administration may induce antiadrenergic effects which may be useful in the treatment of disorders affected by circulating catecholamines. Catecholamines 262-276 dopamine beta-hydroxylase Homo sapiens 49-74 14798-0 1977 Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain. Catecholamines 60-73 phenylethanolamine N-methyltransferase Homo sapiens 0-38 19945-1 1977 At least three substances have been reported to be present in the hypothalamus that can inhibit prolactin release, namely a PIF, catecholamines and acetylcholine. Catecholamines 129-143 prolactin Homo sapiens 96-105 137742-3 1977 (Ethylenedinitrilo)tetraacetic acid (EDTA) and catecholamines protected from and reversed the inhibition of ATP hydrolysis by Mg2+, K+ and ATP. Catecholamines 47-61 mucin 7, secreted Homo sapiens 126-129 19952-1 1977 Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro. Catecholamines 0-14 PIF1 5'-to-3' DNA helicase Homo sapiens 138-141 345745-0 1977 Olfactory bulb dopamine neurons - the A15 catecholamine cell group. Catecholamines 42-55 immunoglobulin kappa variable 1-32 (pseudogene) Homo sapiens 38-41 593524-3 1977 MR rats also showed a greater percentage increase in serum Prl 1 h after blockade of catecholamine synthesis by administration of alpha-methylparatyrosine (alphaMpT). Catecholamines 85-98 protein tyrosine phosphatase 4A1 Rattus norvegicus 59-64 23796-10 1977 These results indicate that the analog, like MIF, exerts effects on central catecholamine turnover. Catecholamines 76-89 macrophage migration inhibitory factor Rattus norvegicus 45-48 140390-2 1977 On using albumins of different origin (human, bovine), the pD2 values for catecholamines differed by more than one order, in correlation to the type of albumin used. Catecholamines 74-88 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 59-62 140390-4 1977 The addition of ascorbic acid (100 microng/ml) raised the catecholamine pD2 values and completely equalized the pD2 values found in both media. Catecholamines 58-71 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 72-75 918144-0 1977 Catecholamine-induced changes in plasma glucose and insulin levels in the unanesthetized rabbit. Catecholamines 0-13 insulin Oryctolagus cuniculus 52-59 1071719-12 1976 Catecholamines stimulated renin release in vitro in proportion to the potency of their action on beta-adrenoreceptors. Catecholamines 0-14 renin Rattus norvegicus 26-31 103108-0 1977 Influence of catecholamine antagonists and depletors on the CNS effects of TRH in rabbits. Catecholamines 13-26 thyrotropin releasing hormone Oryctolagus cuniculus 75-78 201943-5 1977 Catecholamines stimulate c-AMP production in guinea pig atria while glucagon may not. Catecholamines 0-14 cathelicidin antimicrobial peptide Cavia porcellus 25-30 72410-4 1977 In guinea-pig and human lung fragments, catecholamines and PGs increase cyclic AMP levels and inhibit the release of histamine, SRS-A and ECF-A following antigen challenge. Catecholamines 40-54 adenine phosphoribosyltransferase Homo sapiens 79-82 12423-3 1976 The localization and distribution of tyrosine hydroxylase (TH), the first enzyme in the catecholamine synthesis, in the mes- and diencephalon has been studied with the indirect immunofluorescence technique of Coons and collaborators. Catecholamines 88-101 tyrosine hydroxylase Rattus norvegicus 37-57 1071664-0 1976 Interaction of angiotensin II with catecholamines in the circulation of the dog and cat. Catecholamines 35-49 angiotensinogen Rattus norvegicus 15-29 1071664-7 1976 The increase in potency was due to the interaction of angiotensin II with catecholamines on the preparation. Catecholamines 74-88 angiotensinogen Rattus norvegicus 54-68 1071664-10 1976 The results suggest that catecholamines released into the circulating blood by intravenous angiotensin II do not play an important role in the pressor effect of angiotensin II. Catecholamines 25-39 angiotensinogen Rattus norvegicus 91-105 1004027-1 1976 The effects of the catecholamine neurotoxin 6-hydroxydopamine on phenylethanolamine-N-methyl transferase (PNMT) in rat brain has been investigated by biochemical and immunohistochemical analysis. Catecholamines 19-32 phenylethanolamine-N-methyltransferase Rattus norvegicus 65-104 12423-3 1976 The localization and distribution of tyrosine hydroxylase (TH), the first enzyme in the catecholamine synthesis, in the mes- and diencephalon has been studied with the indirect immunofluorescence technique of Coons and collaborators. Catecholamines 88-101 tyrosine hydroxylase Rattus norvegicus 59-61 1004027-1 1976 The effects of the catecholamine neurotoxin 6-hydroxydopamine on phenylethanolamine-N-methyl transferase (PNMT) in rat brain has been investigated by biochemical and immunohistochemical analysis. Catecholamines 19-32 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-110 1015916-0 1976 Effect of some antihypertensive drugs and catecholamine depletors on the plasma renin activity in the rat. Catecholamines 42-55 renin Rattus norvegicus 80-85 1004027-6 1976 The present results show that the PNMT neurons are resistant to the neurotoxic action of 6-hydroxydopamine, possibly due to lack of catecholamine uptake mechanism or due to these neurons having an uptake mechanism with a low affinity for 6-OH-DA. Catecholamines 132-145 phenylethanolamine-N-methyltransferase Rattus norvegicus 34-38 998517-0 1976 Increased plasma catecholamines in high renin hypertension. Catecholamines 17-31 renin Homo sapiens 40-45 998517-2 1976 Seventy percent of hypertensive patients with high renin levels had increased catecholamines compared with a 14% incidence in the combined group with low and normal renin (P less than 0.001). Catecholamines 78-92 renin Homo sapiens 51-56 998517-3 1976 Basal catecholamines were related directly to renin in the hypertensive patients and to blood pressure in the normal (P less than 0.05), but not in the high and low renin subgroups, and inversely to percent increase of catecholamines after standing plus furosemide in hypertensive and normotensive patients (P less than 0.01). Catecholamines 7-21 renin Homo sapiens 47-52 11370235-1 1976 The role of brain catecholamines in the regulation of growth hormone secretion was investigated in pentobarbital-anesthetized dogs by using drugs which modify the function of adrenergic neurons and receptors. Catecholamines 18-32 somatotropin Canis lupus familiaris 54-68 12549-0 1976 Changes in brain catecholamines and spontaneous locomotor activity in response to thyrotropin releasing hormone. Catecholamines 17-31 thyrotropin releasing hormone Rattus norvegicus 82-111 12549-4 1976 Our data suggest that administration of thyrotropin releasing hormone increases the synthesis and perhaps the turnover of brain catecholamines and that this may constitute an underlying mechanism for the anti-depressant action of this synthetic hormone. Catecholamines 128-142 thyrotropin releasing hormone Rattus norvegicus 40-69 1015916-1 1976 The effect of some antihypertensive drugs and catecholamine depletors on the plasma renin activity (PRA) has been investigated in the rat. Catecholamines 46-59 renin Rattus norvegicus 84-89 9989-1 1976 Tyrosine hydroxylase (EC1.14.16.2), presumably the rate-limiting enzyme in the biosynthesis of catecholamines, is known to catalyze the hydroxylation of both phenylalanine and tyrosine. Catecholamines 95-109 tyrosine hydroxylase Rattus norvegicus 0-20 11494-0 1976 Depletion and recovery of catecholamines in the rat adrenal medulla and its relationship with dopamine beta-hydroxylase. Catecholamines 26-40 dopamine beta-hydroxylase Rattus norvegicus 94-119 993149-4 1976 The two groups showed a markedly different pattern of urinary catecholamines excretion on exposure to high altitude and on return to sea level. Catecholamines 62-76 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 133-136 185354-1 1976 There is some evidence in the literature that catecholamines relax uterine and other types of smooth muscle by increasing tissue levels of cyclic adenosine monophosphate (cyclic AMP). Catecholamines 46-60 neurogenin 3 Rattus norvegicus 61-66 826919-3 1976 When 2-deoxy-D-glucose (2-DG) was added to the perfusate, 3H-NE release was also enhanced, whereas insulin perfused at the same rate caused a delated increase in catecholamine levels as reflected by increased radioactivity. Catecholamines 162-175 insulin Homo sapiens 99-106 185109-1 1976 In this work the kinetics of activation of the cyclic AMP-dependent protein kinase by several catecholamines and ACTH, have been studied in rat epididymal fat pads and isolated fat cells. Catecholamines 94-108 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 68-82 999532-6 1976 The concentration of catecholamines and the activity of AChE in them gradually increases. Catecholamines 21-35 acetylcholinesterase Rattus norvegicus 56-60 182323-8 1976 Similar results were obtained when the effect of these manipulations were studied on phenylethanolamine N-methyltransferase, another enzyme in the catecholamine biosynthetic pathway. Catecholamines 147-160 phenylethanolamine-N-methyltransferase Rattus norvegicus 85-123 782312-3 1976 Dopamine-beta-hydroxylase, the enzyme responsible for conversion of dopamine to norepinephrine, is released along with catecholamines from the adrenal medulla and from sympathetic nerve endings. Catecholamines 119-133 dopamine beta-hydroxylase Homo sapiens 0-25 999213-6 1976 Plasma renin activity values correlated positively with 12-hour urinary VMA excretion (p less than 0.01) and negatively with 6-hour urinary sodium excretion (p less than 0.05) before and after Sauna, suggesting the role of catecholamines and sodium depletion in renin response in Sauna. Catecholamines 223-237 renin Homo sapiens 7-12 61795-4 1976 Recent studies have demonstrated that NGF promotes regenerative sprouting of damaged catecholamine-containing neurons in the brain. Catecholamines 85-98 nerve growth factor Homo sapiens 38-41 962889-5 1976 Both catecholamines bound to the microsomal fraction, producing a type II spectral change, with a Ks for noradrenaline of 0.9 mM and for adrenaline of 1.0 mM, and showed other characteristics of type II compounds by inhibited the reduction of cytochrome P-450 by NADPH and exhibiting an enhanced metabolism in the presence of acetone. Catecholamines 5-19 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 243-259 1027234-3 1976 On the basis of activating effectiveness on c-AAT the catecholamines were arranged in decreasing order as follows: adrenaline, isadrine, noradrenaline. Catecholamines 54-68 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 46-49 976208-0 1976 Relationship between plasma renin activity and urinary catecholamines in various types of hypertension. Catecholamines 55-69 renin Homo sapiens 28-33 976208-9 1976 It thus appears that endogenous catecholamines, first of all the ratio between the renin-inhibiting DA and the renin-stimulating NA, participate as one of several factors in the regulation of secretion and of the plasma levels of renin not only in juvenile hypertensive patients with hyperkinetic circulation but also in other types of hypertension. Catecholamines 32-46 renin Homo sapiens 83-88 976208-9 1976 It thus appears that endogenous catecholamines, first of all the ratio between the renin-inhibiting DA and the renin-stimulating NA, participate as one of several factors in the regulation of secretion and of the plasma levels of renin not only in juvenile hypertensive patients with hyperkinetic circulation but also in other types of hypertension. Catecholamines 32-46 renin Homo sapiens 111-116 976208-9 1976 It thus appears that endogenous catecholamines, first of all the ratio between the renin-inhibiting DA and the renin-stimulating NA, participate as one of several factors in the regulation of secretion and of the plasma levels of renin not only in juvenile hypertensive patients with hyperkinetic circulation but also in other types of hypertension. Catecholamines 32-46 renin Homo sapiens 111-116 184127-0 1976 Catecholamine-mediated elevation of cyclic GMP in the rat C-6 glioma cell line. Catecholamines 0-13 complement C6 Rattus norvegicus 58-61 184127-1 1976 Catecholamines cause an elevation of both cyclic GMP and cyclic AMP levels in the rat C-6 glioma cell line. Catecholamines 0-14 complement C6 Rattus norvegicus 86-89 1027234-10 1976 After administration of phentholamine an increase in the AAT activity was caused by an increase in content of catecholamines in the organism. Catecholamines 110-124 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 57-60 933798-0 1976 [Insulin secretion in catecholamine-producing tumors]. Catecholamines 22-35 insulin Homo sapiens 1-8 180004-0 1976 Reversible inactivation of phenylalanine hydroxylase by catecholamines in cultured hepatoma cells. Catecholamines 56-70 phenylalanine hydroxylase Rattus norvegicus 27-52 932994-9 1976 Catecholamine release induced by 56 mM K+ appears to be by exocytosis, since this release is dependent upon extracellular Ca++, and is accompanied by the release of dopamine beta-monooxygenase, but not of lactate dehydrogenase, from the cells. Catecholamines 0-13 dopamine beta-hydroxylase Rattus norvegicus 165-192 201987-3 1976 This membrane-bound phosphoprotein phosphatase may play a role in the reversal of the relaxation-promoting effect of catecholamines on the heart. Catecholamines 117-131 protein phosphatase 1 regulatory inhibitor subunit 2 Homo sapiens 20-46 11370227-11 1976 The receptor on which the released catecholamines act, presumably on the surface of the cells that secrete the hypothalamic hormone that regulates ACTH secretion, appears to be a type of alpha-adrenergic receptor. Catecholamines 35-49 proopiomelanocortin Canis lupus familiaris 147-151 178982-4 1976 These findings suggest that the mechanism for enhanced plasma cAMP release during insulin-induced hypoglycemia is catecholamine dependent. Catecholamines 114-127 insulin Homo sapiens 82-89 14500-7 1976 The results indicate that augmentation in renin release depends on the ratio of the different catecholamines secreted by the pheochromocytoma and their different effe-tiveness in stimulating beta-adrenergic receptors. Catecholamines 94-108 renin Homo sapiens 42-47 14500-9 1976 Normalization of catecholamine-induced enhanced renin release in patients with pheochromocytoma during chronic alpha-adrenergic receptor blockade supports the assumption that (alpha-) adrenergic blocking agents inhibit renin secretion distal to their blockade of specific adrenergic receptors. Catecholamines 17-30 renin Homo sapiens 48-53 14500-9 1976 Normalization of catecholamine-induced enhanced renin release in patients with pheochromocytoma during chronic alpha-adrenergic receptor blockade supports the assumption that (alpha-) adrenergic blocking agents inhibit renin secretion distal to their blockade of specific adrenergic receptors. Catecholamines 17-30 renin Homo sapiens 219-224 1278551-1 1976 In experiments with perfusion of the renal vessels with isotonic saline solution, the ability of angiotensin-II to activate the smooth muscle cells of these vessels was shown: both by direct myotropic action and in an indirect way - by catecholamines. Catecholamines 236-250 angiotensinogen Homo sapiens 97-111 4944-0 1976 Purification of a catecholamine-rich fraction with prolactin release-inhibiting factor (PIF) activity from porcine hypothalami. Catecholamines 18-31 gonadotropin releasing hormone 1 Homo sapiens 51-86 4944-0 1976 Purification of a catecholamine-rich fraction with prolactin release-inhibiting factor (PIF) activity from porcine hypothalami. Catecholamines 18-31 gonadotropin releasing hormone 1 Homo sapiens 88-91 7918-0 1976 The effect of prolonged vasopressin administration on the level and metabolism of catecholamines in the rat brain and kidneys. Catecholamines 82-96 arginine vasopressin Rattus norvegicus 24-35 941687-0 1976 Turnover of catecholamines in some regions of the rat brain during prolonged vasopressin administration and after its withdrawal. Catecholamines 12-26 arginine vasopressin Rattus norvegicus 77-88 945099-1 1976 Significant sibling-sibling and within-family correlations of human red blood cell catechol-o-methyl transferase activity have suggested a high degree of genetic control over levels of activity of this catecholamine-related enzyme. Catecholamines 202-215 catechol-O-methyltransferase Homo sapiens 83-112 952582-7 1976 The results of these studies indicate that ketamine prevented catecholamines from reaching the intracellular site of COMT. Catecholamines 62-76 catechol-O-methyltransferase Rattus norvegicus 117-121 958503-1 1976 Cold exposure of rats for 4 h and simultaneous inhibition of dopamine beta-hydroxylase by FLA-63 (25mg/kg) led to a reduction of the catecholamine content of the adrenal medulla by 46% and of the brain by 68%. Catecholamines 133-146 dopamine beta-hydroxylase Rattus norvegicus 61-86 4982-11 1976 These results indicate that catecholamine release accompanying acidosis attenuates the change in pHI and increases the effective buffer value of cardiac and skeletal muscle. Catecholamines 28-41 glucose-6-phosphate isomerase Rattus norvegicus 97-100 3266-4 1976 PNMT was detectable in gray but not white matter, and was considerably lower in activity than the other catecholamine synthetic enzymes. Catecholamines 104-117 phenylethanolamine N-methyltransferase Oryctolagus cuniculus 0-4 1263833-3 1976 It is suggested that ethanol may deplete catecholamine stores in the neurons of the ventromedial nucleus of the hypothalamus and may thereby impair secretion of growth hormone releasing factor. Catecholamines 41-54 growth hormone releasing hormone Homo sapiens 161-192 1257835-3 1976 It is assumed that the increase in renin is secondary to catecholamine stimulation. Catecholamines 57-70 renin Homo sapiens 35-40 992195-8 1976 The results obtained emphasize the influence of catecholamines on insulin responsiveness, possibly constituting a major contribution to the diabetic state. Catecholamines 48-62 insulin Homo sapiens 66-73 1261489-5 1976 While the increase in serum PRL induced by R seems to be directly relatable to its known catecholamine depletion, the circadian rhythm of PRL secretion induced by E2 seems to be influenced or mediated by central neural mechanisms. Catecholamines 89-102 prolactin Rattus norvegicus 28-31 1255585-1 1976 The activity of monoamine oxidase (MAO), an enzyme which metabolized catecholamines and indoleamines, was determined in rat placenta at various stages of gestation, in human term placenta, and in choriocarcinoma grown in culture. Catecholamines 69-83 monoamine oxidase A Rattus norvegicus 16-33 1255585-1 1976 The activity of monoamine oxidase (MAO), an enzyme which metabolized catecholamines and indoleamines, was determined in rat placenta at various stages of gestation, in human term placenta, and in choriocarcinoma grown in culture. Catecholamines 69-83 monoamine oxidase A Rattus norvegicus 35-38 9301-2 1976 Effect on the response of plasma catecholamines and plasma renin activity to insulin-induced hypoglycemia. Catecholamines 33-47 insulin Homo sapiens 77-84 55662-3 1976 There is evidence that catecholamines and indolamines directly affect prolactin release. Catecholamines 23-37 prolactin Homo sapiens 70-79 9301-3 1976 The effect of insulin-induced hypoglycemia on the blood levels of catecholamines and renin activity has been studied in five patients with moderate hypertension before and after treatment for 3 - 8 months with penbutolol (PEN) 20 - 30 mg twice daily. Catecholamines 66-80 insulin Homo sapiens 14-21 1254939-6 1976 Dopamine-beta-hydroxylase inhibition produced by FLA-63, fusaric acid or diethyldithiocarbamate resulted in all cases in a 50-70% reduction of the catecholamine fluorescence in the subependymal layer, whereas only minute effects were observed in the lateral palisade zone. Catecholamines 147-160 dopamine beta-hydroxylase Rattus norvegicus 0-25 13627-0 1976 Control of prolactin secretion by the hypothalamic catecholamines. Catecholamines 51-65 prolactin Homo sapiens 11-20 1256000-6 1976 The fact that a correlation was observed in the normal group is compatible with the hypothesis that catecholamines are involved in the regulation of the renin-angiotensin-aldosterone system. Catecholamines 100-114 renin Homo sapiens 153-158 941777-7 1976 Ascorbic acid affects catecholamine biosynthesis at two metabolic loci; it is the necessary cofactor for dopamine-beta-hydroxylase and, by maintaining biopterin in reduced form, facilitates tyrosine hydroxylase holoenzyme activity. Catecholamines 22-35 dopamine beta-hydroxylase Homo sapiens 105-130 1030499-2 1976 Injections of the serotonin blocker cyproheptadine (Cypro) and a catecholamine, dopamine (DA), each led to reductions in the level of serum GH in 21 to 22 day fetuses and in neonates up to 3 days after birth. Catecholamines 65-78 gonadotropin releasing hormone receptor Rattus norvegicus 140-142 139976-0 1976 [Correlation between the dopamine-beta-hydroxylase activity and the level of plasma catecholamines during muscular exercise]. Catecholamines 84-98 dopamine beta-hydroxylase Homo sapiens 25-50 765118-0 1976 Effects of intravenous infusion of catecholamines on rat plasma luteinizing hormone and prolactin concentrations. Catecholamines 35-49 prolactin Rattus norvegicus 88-97 1244223-8 1976 Further studies utilizing direct correlation of plasma and urine catecholamines with serum DBH activity are needed to establish its relationship to sympathetic nervous system activity. Catecholamines 65-79 dopamine beta-hydroxylase Homo sapiens 91-94 12070-3 1976 Catecholamines would be expected to bind to sites other than the adrenergic receptor (uptake 1, uptake 2, nerve vesicles, catecholamine-O-methyl transferase and serum albumin). Catecholamines 0-14 albumin Oryctolagus cuniculus 167-174 1028951-0 1976 Selective actions of prolactin on catecholamine turnover in the hypothalamus and on serum LH and FSH. Catecholamines 34-47 prolactin Rattus norvegicus 21-30 1206325-0 1975 Effects of injections of monoamine oxidase inhibitor or saline into the uterus in late pregnancy on uterine catecholamine levels related to abnormal parturition in rats. Catecholamines 108-121 monoamine oxidase A Rattus norvegicus 25-42 1028951-1 1976 The effects of prolactin (PRL) administration on catecholamine turnover in various brain regions of ovariectomized rats were determined by observing the decline of dopamine and norepinephrine concentrations after alpha-methyltyrosine (alphaMT) administration. Catecholamines 49-62 prolactin Rattus norvegicus 15-24 1028951-1 1976 The effects of prolactin (PRL) administration on catecholamine turnover in various brain regions of ovariectomized rats were determined by observing the decline of dopamine and norepinephrine concentrations after alpha-methyltyrosine (alphaMT) administration. Catecholamines 49-62 prolactin Rattus norvegicus 26-29 2125-5 1975 These findings support the hypothesis that insulin releases catecholamines from the myocardium. Catecholamines 60-74 insulin Oryctolagus cuniculus 43-50 1204291-10 1975 These observations suggest that catecholamines stimulate renin secretion by an intrarenal effect which is largely independent of changes in renal perfusion pressure. Catecholamines 32-46 renin Rattus norvegicus 57-62 1206326-11 1975 The results indicate that oxytocin and prolactin release induced by suckling in lactating rats is inhibited by an increase of catecholamines at the hypothalamic-hypophysial axis. Catecholamines 126-140 prolactin Rattus norvegicus 39-48 1239966-8 1975 The postoperative increase of plasma renin and consequently plasma aldosterone is possibly a consequence of anaesthetic induced impaired kidney perfusion and/or catecholamine mediated stimulation of renin release. Catecholamines 161-174 renin Homo sapiens 37-42 1239966-8 1975 The postoperative increase of plasma renin and consequently plasma aldosterone is possibly a consequence of anaesthetic induced impaired kidney perfusion and/or catecholamine mediated stimulation of renin release. Catecholamines 161-174 renin Homo sapiens 199-204 1166891-0 1975 Growth hormone catecholamines in affective disease. Catecholamines 15-29 growth hormone 1 Homo sapiens 0-14 811527-0 1975 [Influences of PCB on the brain catecholamine levels in rats (author"s transl)]. Catecholamines 32-45 pyruvate carboxylase Rattus norvegicus 15-18 1190521-1 1975 Because dopamine-beta-hydroxylase (DBH) is released from storage vesicles in adrenergic nerves and the adrenal medulla along with catecholamines, determination of circulating levels of this enzyme might serve as an index of sympathoadrenal activity. Catecholamines 130-144 dopamine beta-hydroxylase Canis lupus familiaris 8-33 1190521-1 1975 Because dopamine-beta-hydroxylase (DBH) is released from storage vesicles in adrenergic nerves and the adrenal medulla along with catecholamines, determination of circulating levels of this enzyme might serve as an index of sympathoadrenal activity. Catecholamines 130-144 dopamine beta-hydroxylase Canis lupus familiaris 35-38 4815-0 1975 Alpha-MSH and MIF-I effects on catecholamine levels and synthesis in various rat brain areas. Catecholamines 31-44 macrophage migration inhibitory factor Rattus norvegicus 14-17 1193011-0 1975 Potentiation of suckling-induced release of prolactin by inhibition of brain catecholamine synthesis. Catecholamines 77-90 prolactin Rattus norvegicus 44-53 1193011-7 1975 These results suggest that inhibition or catecholamine synthesis had a facilitatory effect on the brain mechanisms responsible for prolactin release in response to suckling. Catecholamines 41-54 prolactin Rattus norvegicus 131-140 1236608-8 1975 Since the vasoconstrictor effect of clonidine is considered to be due to alpha-adrenergic stimulation, this observation is similar to a previous study reporting suppression of renin secretion by vasoconstrictor infusions of catecholamines (Vandongen & Peart, 1974). Catecholamines 224-238 renin Rattus norvegicus 176-181 1291-3 1975 The data on cerebral vascular responses to microapplication of mCSF solutions with various pH, potassium and catecholamines concentrations, suggest that rapid regulatory chains may be conditioned by potassium and neurogenic vascular effects, while slow ones could be mediated by CO2 and related pH changes. Catecholamines 109-123 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 63-67 1157220-1 1975 Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. Catecholamines 52-66 renin Rattus norvegicus 77-82 171072-9 1975 The sympathetic neurons are extremely sensitive to nerve growth factor (NGF) which caused an increase in the size of the cell bodies, the number of nerve fibres regenerating, the rate of axonal growth and synthesis of catecholamines. Catecholamines 218-232 nerve growth factor Homo sapiens 72-75 1222215-0 1975 Effect of catecholamines on renin release in vitro. Catecholamines 10-24 renin Homo sapiens 28-33 171072-9 1975 The sympathetic neurons are extremely sensitive to nerve growth factor (NGF) which caused an increase in the size of the cell bodies, the number of nerve fibres regenerating, the rate of axonal growth and synthesis of catecholamines. Catecholamines 218-232 nerve growth factor Homo sapiens 51-70 169167-0 1975 Supersensitivity to catecholamines after impairment of extraneuronal uptake or catechol-O-methyl transferase. Catecholamines 20-34 catechol-O-methyltransferase Homo sapiens 79-108 169167-1 1975 In cat papillary muscle and nictitating membrane block of extraneuronal catechol-O-methyl transferase (COMT) by 3",4"-dihydroxy-alpha-methyl propiophenone (U-0521) or of extraneuronal uptake by hydrocortisone causes supersensitivity to catecholamines whenever the experimental conditions result in a high sensitivity of the organ to catecholamines. Catecholamines 236-250 catechol-O-methyltransferase Homo sapiens 103-107 169167-1 1975 In cat papillary muscle and nictitating membrane block of extraneuronal catechol-O-methyl transferase (COMT) by 3",4"-dihydroxy-alpha-methyl propiophenone (U-0521) or of extraneuronal uptake by hydrocortisone causes supersensitivity to catecholamines whenever the experimental conditions result in a high sensitivity of the organ to catecholamines. Catecholamines 333-347 catechol-O-methyltransferase Homo sapiens 103-107 1174970-4 1975 Weanling and adult weaver, reeler and staggerer mice all manifest greatly increased specific catecholamine fluorescence per unit area in cerebellar cortex, but the patterns of fluorescent fibers are distinctive. Catecholamines 93-106 RAR-related orphan receptor alpha Mus musculus 38-47 808558-2 1975 Since catecholamines may be involved in the regulation of both thyrotropin (TSH) and prolactin (PRL) release from the pituitary, the effect of propranolol on the TSH and PRL responses to thyrotropin-releasing hormone (TRH) was also examined. Catecholamines 6-20 prolactin Homo sapiens 85-94 808558-2 1975 Since catecholamines may be involved in the regulation of both thyrotropin (TSH) and prolactin (PRL) release from the pituitary, the effect of propranolol on the TSH and PRL responses to thyrotropin-releasing hormone (TRH) was also examined. Catecholamines 6-20 prolactin Homo sapiens 96-99 1237420-1 1975 In recent years many investigators have reported the role of the sympathetic nervous system and the catecholamines in the regulation of renin secretion. Catecholamines 100-114 renin Homo sapiens 136-141 171652-3 1975 Ornithine decarboxylase activity is also elevated in confluent C6-BU-1 glioma cells treated with dibutyrylcAMP and theophylline, or after the glioma cells are fed with a serum-depleted medium in the presence of catecholamines and inhibitors of cyclic nucleotide phosphodiesterase. Catecholamines 211-225 ornithine decarboxylase 1 Rattus norvegicus 0-23 239788-0 1975 Studies on tyrosine hydroxylase in neuroblastoma in relation to urinary levels of catecholamine metabolites. Catecholamines 82-95 tyrosine hydroxylase Homo sapiens 11-31 1157091-0 1975 [Relation between plasma renin activity and urinary catecholamines in individual types of hypertension (author"s transl)]. Catecholamines 52-66 renin Homo sapiens 25-30 1151750-12 1975 These data suggest that in the presence of high circulating levels of female sex hormones or other female factors (e.g., prolactin) enhanced binding or sequestration of potential activator ions occurs which increases the responsiveness of the tissue to catecholamines. Catecholamines 253-267 prolactin Rattus norvegicus 121-130 1077779-0 1975 Relationships between plasma renin activity and urinary and plasma catecholamines. Catecholamines 67-81 renin Homo sapiens 29-34 1155601-3 1975 In addition, the effect on the norepinephrine dose-response curve of the combination of a methyixanthine and U-0521,the latter a potent inhibitor of catechol O-methyltransferase, the major enzyme of catecholamine inactivation in vascular tissue, did not differ from that of U-0521 alone. Catecholamines 199-212 catechol-O-methyltransferase Homo sapiens 149-177 1079183-1 1975 The activity of catecholamine degrading enzymes (catechol-O-methyltransferase--COMT and monoamine oxidase--MAO) in separated adrenal cortex and medulla was measured in rats stressed by a singel or repeated immobilization. Catecholamines 16-29 catechol-O-methyltransferase Rattus norvegicus 79-83 1079183-6 1975 It was concluded that the findings of changed activity of catecholamine degrading enzymes, namely a decreased activity of COMT in both adrenal cortex and medulla in repeatedly stressed rats, might show a possible participation of these enzymes in increased catecholamine content in adrenals of repeatedly stressed animals. Catecholamines 58-71 catechol-O-methyltransferase Rattus norvegicus 122-126 1079183-6 1975 It was concluded that the findings of changed activity of catecholamine degrading enzymes, namely a decreased activity of COMT in both adrenal cortex and medulla in repeatedly stressed rats, might show a possible participation of these enzymes in increased catecholamine content in adrenals of repeatedly stressed animals. Catecholamines 257-270 catechol-O-methyltransferase Rattus norvegicus 122-126 1127500-2 1975 Since MAO is an important enzyme in inactivation of catecholamines, urinary excretion of DA, NE, E, MN-NMN, and VMA was measured in 24-hour samples from 11 iron-deficient children before and after treatment with intramuscular iron. Catecholamines 52-66 monoamine oxidase A Rattus norvegicus 6-9 1057183-1 1975 Injection of frogs with beta-adrenergic catecholamines for 1-24 hr produces marked subsensitivity of the erythrocyte membrane adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1.] Catecholamines 40-54 adenylate cyclase 10 Homo sapiens 145-168 239260-11 1975 The some patients with EH may have a renin-catecholamine relationship and both pressor systems may be linked to be a pathogenic factor for the elevation of blood pressure. Catecholamines 43-56 renin Homo sapiens 37-42 1233217-0 1975 Correlation between increased dopamine-beta-hydroxylase activity and catecholamine concentration in plasma: determination of acute changes in sympathetic activity in man. Catecholamines 69-82 dopamine beta-hydroxylase Homo sapiens 30-55 124056-4 1975 It is supposed that (Na-+--K-+)-activated ATP-ase was directly involved in the action mechanism of catecholamines on the system of active sodium transport in frog skin. Catecholamines 99-113 dynein axonemal heavy chain 8 Homo sapiens 42-49 236194-14 1975 These data indicate that under the present experimental conditions, the low pressor effect observed with these angiotensin II antagonists appears to be due to both adrenal catecholamine release and a direct vasoconstrictor effect. Catecholamines 172-185 angiotensinogen Rattus norvegicus 111-125 164620-16 1975 The endocrine system plays a paramount role in glucokinase adaptation, since insulin is essential for glucose-dependent glucokinase induction and, on the other hand, glucagon, catecholamines and cyclic AMP prevent the induction. Catecholamines 176-190 glucokinase Rattus norvegicus 47-58 1124146-7 1975 The data indicate that these insulin-induced changes are significantly, though variably, attributable to beta-adrenergic activity on the part of endogenous catecholamines released during insulin-induced hypoglycaemia. Catecholamines 156-170 insulin Homo sapiens 29-36 1124146-7 1975 The data indicate that these insulin-induced changes are significantly, though variably, attributable to beta-adrenergic activity on the part of endogenous catecholamines released during insulin-induced hypoglycaemia. Catecholamines 156-170 insulin Homo sapiens 187-194 163152-0 1975 Catecholamine-dependent cyclic adenosine monophosphate and renin in the dog kidney. Catecholamines 0-13 renin Canis lupus familiaris 59-64 163152-2 1975 Therefore, the possible role of catecholamine-dependent cyclic AMP in the release of renin was investigated in lithium-treated dogs both in vivo and vitro. Catecholamines 32-45 renin Canis lupus familiaris 85-90 124057-4 1975 A more pronounced increase in catecholamine excretion was seen in insulin therapy apparently in connection with greater variations in glycemia level. Catecholamines 30-43 insulin Homo sapiens 66-73 1153081-0 1975 Effect of a dopamine beta-hydroxylase inhibitor on tissue catecholamine levels in spontaneously hypertensive rats subjected to immobilization-cold stress. Catecholamines 58-71 dopamine beta-hydroxylase Rattus norvegicus 12-37 235760-1 1975 Tyrosine hydroxylase (EC 1.14.16.2), the enzyme catalyzing the rate-limiting step in catecholamine biosynthesis, was localized by electron microscopy within noradrenergic neurons of the nucleus locus coeruleus of the rat brain with a specific antibody to tyrosine hydroxylase labeled by the peroxidase-antiperoxidase immunohistochemical method. Catecholamines 85-98 tyrosine hydroxylase Rattus norvegicus 0-20 170549-3 1975 A ROLE OF VASOPRESSIN IS IMPLICATED SINCE NEITHER MAN NOR DOG WITHOUT A PITUITARY SOURCE OF VASOPRESSIN DEMONSTRATE THE SAME EFFECT OF CATECHOLAMINES ON WATER EXCRETION AS OBSERVED IN INTACT MAN AND DOG. Catecholamines 135-149 arginine vasopressin Homo sapiens 10-21 1113939-2 1975 The interpretation of this phenomenon is discussed and importance is attached to catecholamine mediation, since administration of a beta-blocking agent is sufficient to cause a significant reduction in the extent of the phenomenon. Catecholamines 81-94 amyloid beta precursor protein Homo sapiens 130-136 234804-6 1975 There was a weak, but not significant, correlation of plasma catecholamine concentration with serum dopamine-beta-hydroxylase activity. Catecholamines 61-74 dopamine beta-hydroxylase Homo sapiens 100-125 1229805-4 1975 These findings suggest that changes in plasma pyruvate, lactate and inorganic phosphates induced by insulin, and regarded as espressions of its peripheral metabolism, are greatly dependent on the beta-adrenergic effect of the endogenous catecholamines released during the time when blood glucose values are low. Catecholamines 237-251 insulin Homo sapiens 100-107 1183075-0 1975 Direct intrarenal action of catecholamines on renin secretion. Catecholamines 28-42 renin Homo sapiens 46-51 1123720-0 1975 Inhibition of brain catecholamine synthesis and release of prolactin and luteinizing hormone in the ovariectomized rat. Catecholamines 20-33 prolactin Rattus norvegicus 59-68 1123720-6 1975 The time course of the inhibition of catecholamine synthesis closely paralleled the increase in plasma prolactin concentration. Catecholamines 37-50 prolactin Rattus norvegicus 103-112 1123720-8 1975 The results suggest that catecholamine-containing neurons exert a tonic inhibitory influence on the release of prolactin in ovariectomized rats. Catecholamines 25-38 prolactin Rattus norvegicus 111-120 171710-3 1975 These findings are suggestive of a second messenger role of cyclic AMP in the beta-adrenoreceptor-mediated actions of catecholamines on myocardial contractile force and relaxation, in which Ca2+ would serve as a third messenger and be subject, respectively, to more effective removal from its binding sites on troponin. Catecholamines 118-132 adenine phosphoribosyltransferase Homo sapiens 67-70 171710-4 1975 An alternative interpretation regards Ca2+ and cyclic AMP as interdependent twin second messengers in the catecholamine-induced inotropism. Catecholamines 106-119 adenine phosphoribosyltransferase Homo sapiens 54-57 171710-5 1975 Since the physiological meaning of the reported effects of cyclic AMP on isolated myocardial membrane preparations is far from established an instances of a dissociation between the effects of catecholamines on myocardial contractile force and cyclic AMP levels have been observed, there is still room for hypotheses that relegate cyclic AMP to a nonobligatory, at most, supportive role in the action of the catecholamines on cardiac contraction. Catecholamines 408-422 adenine phosphoribosyltransferase Homo sapiens 251-254 171710-5 1975 Since the physiological meaning of the reported effects of cyclic AMP on isolated myocardial membrane preparations is far from established an instances of a dissociation between the effects of catecholamines on myocardial contractile force and cyclic AMP levels have been observed, there is still room for hypotheses that relegate cyclic AMP to a nonobligatory, at most, supportive role in the action of the catecholamines on cardiac contraction. Catecholamines 408-422 adenine phosphoribosyltransferase Homo sapiens 251-254 813283-1 1975 The effect of catecholamines, represented by epinephrine and norepinephrine, on the activity of phospholipase A2 from bee venom was studied. Catecholamines 14-28 phospholipase A2 group IB Homo sapiens 96-112 813283-5 1975 Certain arrhythmias and ion imbalances might be caused by catecholamine activation of phospholipase A2. Catecholamines 58-71 phospholipase A2 group IB Homo sapiens 86-102 4372093-0 1974 The effect of catecholamine analogues upon amylase secretion from the mouse parotid gland in vivo:relationship to changes in cyclic AMP and cyclic GMP levels. Catecholamines 14-27 5'-nucleotidase, cytosolic II Mus musculus 147-150 4214694-0 1974 Effect of catecholamines on the TRH-stimulated release of prolactin and growth hormone from sheep pituitaries in vitro. Catecholamines 10-24 prolactin Ovis aries 58-67 4152853-0 1974 Effect of serum albumin upon the response of the rat isolated superfused anococcygeus muscle to catecholamines and to nerve stimulation. Catecholamines 96-110 albumin Rattus norvegicus 10-23 4363380-3 1974 N(6), O(2")-dibutyryl adenosine 3",5"-monophosphate (dibutyryl-cAMP) also caused transient frequency increases resembling in time-course those observed with catecholamines. Catecholamines 157-171 cathelicidin antimicrobial peptide Rattus norvegicus 63-67 4370333-0 1974 Renin release by rat kidney slices in vitro: effects of cations and catecholamines. Catecholamines 68-82 renin Rattus norvegicus 0-5 4367898-0 1974 Inhibition of angiotensin-induced adrenal catecholamine release by 8-substituted analogs of angiotensin II. Catecholamines 42-55 angiotensinogen Homo sapiens 92-106 4821068-0 1974 Dihydropteridine reductase in rat brain: regional distribution and the effect of catecholamine-depleting drugs. Catecholamines 81-94 quinoid dihydropteridine reductase Rattus norvegicus 0-26 4809562-3 1974 Those with low DBH activity had lower values for urinary catecholamine excretion (31 +/- 3 micrograms), with normal and stable blood pressure; those with high DBH activity had higher values for urinary catecholamine excretion (72 +/- 6 micrograms), with greater lability of arterial blood pressure. Catecholamines 57-70 dopamine beta-hydroxylase Homo sapiens 15-18 4207131-10 1974 In the presence or the absence of extracellular Ca(2+), the increase in the output of catecholamines induced by Na(+) deprivation was accompanied by an increase in the output of dopamine beta-hydroxylase, but not of lactate dehydrogenase. Catecholamines 86-100 dopamine beta-hydroxylase Bos taurus 178-203 4821455-0 1974 Half life of CS2 in rats in relation to its effect on brain catecholamines. Catecholamines 60-74 calsyntenin 2 Rattus norvegicus 13-16 4809562-3 1974 Those with low DBH activity had lower values for urinary catecholamine excretion (31 +/- 3 micrograms), with normal and stable blood pressure; those with high DBH activity had higher values for urinary catecholamine excretion (72 +/- 6 micrograms), with greater lability of arterial blood pressure. Catecholamines 202-215 dopamine beta-hydroxylase Homo sapiens 159-162 4545594-0 1974 Proceedings: Serum dopamine-beta-hydroxylase (regulation of catecholamine-release by various agents). Catecholamines 60-73 dopamine beta-hydroxylase Homo sapiens 19-44 4374068-0 1974 The role of brain catecholamines in the regulation of ACTH secretion. Catecholamines 18-32 proopiomelanocortin Homo sapiens 54-58 4277023-0 1974 Lowering of kininogen in rat blood by catecholamines. Catecholamines 38-52 kininogen 2-like 1 Rattus norvegicus 12-21 4766218-2 1973 Quantitative estimates have been made of the binding of catecholamines to purified collagen and elastin, and the factors influencing this binding have been investigated.2. Catecholamines 56-70 elastin Rattus norvegicus 96-103 4746492-1 1973 The effect of treatment with the factor that inhibits the release of melanocyte stimulating hormone (MSH) identified as 1-prolyl-1-leucylglycinamide (MIF) on brain catecholamine synthesis was examined in normal and hypophysectomized rats. Catecholamines 164-177 macrophage migration inhibitory factor Rattus norvegicus 150-153 4766218-5 1973 Tetracyclines inhibit the binding of catecholamines to collagen and elastin. Catecholamines 37-51 elastin Rattus norvegicus 68-75 4541674-1 1973 Previous studies have demonstrated that the secretion of human prolactin is regulated primarily by factors that influence catecholamines of the hypothalamus. Catecholamines 122-136 prolactin Homo sapiens 63-72 4749029-0 1973 [Possibility of insulin inhibition during the process of mobilization of catecholamines in stress]. Catecholamines 73-87 insulin Homo sapiens 16-23 4730445-1 1973 Dopamine-beta-hydroxylase activity is released into the blood with catecholamines from the adrenal medulla and sympathetic nerves. Catecholamines 67-81 dopamine beta-hydroxylase Homo sapiens 0-25 4352945-0 1973 The effect of intravenous catecholamines on circulating levels of growth hormone, corticotrophin and cortisol in man. Catecholamines 26-40 growth hormone 1 Homo sapiens 66-80 4352446-0 1973 Interaction of glucagon and catecholamines in the regulation of serine dehydratase. Catecholamines 28-42 serine dehydratase Homo sapiens 64-82 4196594-0 1973 Tyrosine and catecholamine metabolism in wild-type Drosophila melanogaster and a mutant, ebony. Catecholamines 13-26 ebony Drosophila melanogaster 89-94 4148688-0 1973 Effect of catecholamines on plasma growth hormone in dogs. Catecholamines 10-24 somatotropin Canis lupus familiaris 35-49 4709002-0 1973 The effects of drugs which modify catecholamine synthesis on serum prolactin in rats with median eminence lesions. Catecholamines 34-47 prolactin Rattus norvegicus 67-76 4350474-1 1973 Osmotic release of beta-glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3",5"-monophosphate, and accelerated by cholinergic agents and guanosine 3",5"-monophosphate. Catecholamines 97-111 glucuronidase beta Homo sapiens 19-37 4349947-10 1973 Combinations of 1 muM hydrocortisone and 1 muM epinephrine were sometimes additive or synergistic but in many instances higher glucocorticoid concentrations were needed to obtain augmentation of the catecholamine response. Catecholamines 199-212 latexin Homo sapiens 18-21 4349947-10 1973 Combinations of 1 muM hydrocortisone and 1 muM epinephrine were sometimes additive or synergistic but in many instances higher glucocorticoid concentrations were needed to obtain augmentation of the catecholamine response. Catecholamines 199-212 latexin Homo sapiens 43-46 4789775-0 1973 Role of indoleamines and catecholamines in the control of gonadotrophin and growth hormone secretion. Catecholamines 25-39 growth hormone 1 Homo sapiens 76-90 4269287-4 1973 When H44/68 is administered together with reserpine to inhibit the synthesis and storage of cerebral catecholamines, and thus bring about their total depletion from the brain, the cerebral glycogenolytic effect of amphetamine is abolished.4. Catecholamines 101-115 histocompatibility 44 Mus musculus 5-11 4145699-0 1973 Catecholamine response of chickens to exogenous insulin and tolbutamide. Catecholamines 0-13 insulin Gallus gallus 48-55 4681932-0 1973 Hypothalamic catecholamine effects on plasma levels of prolactin and growth hormone in sheep. Catecholamines 13-26 prolactin Ovis aries 55-64 4681932-0 1973 Hypothalamic catecholamine effects on plasma levels of prolactin and growth hormone in sheep. Catecholamines 13-26 somatotropin Ovis aries 69-83 4714684-0 1973 [Action of catecholamines on the level of growth hormone and glucolipid behavior in human obesity]. Catecholamines 11-25 growth hormone 1 Homo sapiens 42-56 4346812-0 1973 ACTH-induced alterations in catecholamine metabolism in man. Catecholamines 28-41 proopiomelanocortin Homo sapiens 0-4 4539510-0 1972 Catecholamine secretion from the adrenal gland treated with neuraminidase, protamine or alkylating agent. Catecholamines 0-13 neuraminidase 1 Homo sapiens 60-73 4679299-2 1972 Effect of catecholamines on insulin secretion in response to tolbutamide]. Catecholamines 10-24 insulin Homo sapiens 28-35 4346853-1 1972 The effect of angiotensin-II-amide on the biosynthesis of catecholamines (CA) has been studied in a number of isolated tissues in vitro.2. Catecholamines 58-72 angiotensinogen Rattus norvegicus 14-28 4640070-3 1972 Because the release of human growth hormone appears to be closely related to brain catecholamine metabolism, the deficient responses in the depressed patients may provide further support to the concept of a neurochemical defect in depressive illness. Catecholamines 83-96 growth hormone 1 Homo sapiens 29-43 5045923-0 1972 Stimulation of yeast hexokinase by catecholamines and related compounds. Catecholamines 35-49 hexokinase Saccharomyces cerevisiae S288C 21-31 5031138-0 1972 The interaction between amphetamine and catecholamines on cardiac phosphorylase and adenyl cyclase. Catecholamines 40-54 adenylate cyclase 1 Homo sapiens 84-98 4402349-0 1972 Tyrosine hydroxylase in human adrenal and pheochromocytoma: localization, kinetics, and catecholamine inhibition. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 0-20 5019894-0 1972 [Blood antithrombin activity in intact and adrenalectomized animals during administration of catecholamines and corticosteroids]. Catecholamines 93-107 serpin family C member 1 Homo sapiens 7-19 5036567-0 1972 Antagonism of catecholamine inhibition of insulin secretion by methysergide. Catecholamines 14-27 insulin Homo sapiens 42-49 4375668-0 1972 Adenyl cyclase-stimulating catecholamines as modifiers of antibody formation. Catecholamines 27-41 adenylate cyclase 1 Homo sapiens 0-14 4332750-0 1971 Release of catecholamines during the induction of and recovery from tachyphylaxis to angiotensin II. Catecholamines 11-25 angiotensinogen Homo sapiens 85-99 4402984-5 1971 The increase in PNMT activity may be a response to increased utilization of catecholamines.3. Catecholamines 76-90 phenylethanolamine-N-methyltransferase Rattus norvegicus 16-20 5152027-6 1971 Hypoglycaemia induced by insulin increased catecholamine secretion, with the adrenaline to noradrenaline ratio significantly higher than in the adrenal gland itself.6. Catecholamines 43-56 insulin Homo sapiens 25-32 5135722-1 1971 Dopamine-beta-hydroxylase(DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves. Catecholamines 144-157 dopamine beta-hydroxylase Cavia porcellus 0-25 5135722-1 1971 Dopamine-beta-hydroxylase(DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves. Catecholamines 144-157 dopamine beta-hydroxylase Cavia porcellus 26-29 5572168-1 1971 Dopamine-beta- hydroxylase is an enzyme that is localized to catecholamine-containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Catecholamines 61-74 dopamine beta-hydroxylase Rattus norvegicus 0-26 5158204-4 1971 Compounds which inhibit catechol-O-methyltransferase (pyrogallol, tropolone, U-0521) potentiated responses to catecholamines and abolished the enhancing effect of theophylline and caffeine. Catecholamines 110-124 catechol O-methyltransferase Oryctolagus cuniculus 24-52 5165490-0 1971 Two mechanisms for the inhibition in vitro of phenylalanine hydroxylase by catecholamines. Catecholamines 75-89 phenylalanine hydroxylase Homo sapiens 46-71 5578236-14 1971 If peripheral dopa decarboxylase is selectively inhibited, a centrally mediated hypotensive effect, probably secondary to the accumulation of catecholamines in the brain, becomes apparent. Catecholamines 142-156 dopa decarboxylase Canis lupus familiaris 14-32 5289368-0 1971 Dihydropteridine reductase: implication on the regulation of catecholamine biosynthesis. Catecholamines 61-74 quinoid dihydropteridine reductase Homo sapiens 0-26 5289368-1 1971 The low tissue concentrations of tetrahydrobiopterin, as well as the antagonism between the catecholamine feedback inhibition of tyrosine hydroxylase and the reduced cofactor concentrations, suggest that dihydropteridine reductase may play an important role in the regulation of catecholamine biosynthesis. Catecholamines 92-105 quinoid dihydropteridine reductase Homo sapiens 204-230 5289368-1 1971 The low tissue concentrations of tetrahydrobiopterin, as well as the antagonism between the catecholamine feedback inhibition of tyrosine hydroxylase and the reduced cofactor concentrations, suggest that dihydropteridine reductase may play an important role in the regulation of catecholamine biosynthesis. Catecholamines 279-292 quinoid dihydropteridine reductase Homo sapiens 204-230 5289368-3 1971 This system has several important characteristics: (a) the rate of dihydroxyphenylalanine formation can be controlled by the concentration of dihydropteridine reductase; (b) low concentrations of catecholamines (2 x 10(-5) M) can produce a marked inhibition of tyrosine hydroxylase activity; and (c) the catecholamine feedback-inhibition of tyrosine hydroxylase can be antagonized by increasing concentrations of dihydropteridine reductase. Catecholamines 196-210 quinoid dihydropteridine reductase Homo sapiens 142-168 5289368-3 1971 This system has several important characteristics: (a) the rate of dihydroxyphenylalanine formation can be controlled by the concentration of dihydropteridine reductase; (b) low concentrations of catecholamines (2 x 10(-5) M) can produce a marked inhibition of tyrosine hydroxylase activity; and (c) the catecholamine feedback-inhibition of tyrosine hydroxylase can be antagonized by increasing concentrations of dihydropteridine reductase. Catecholamines 196-210 quinoid dihydropteridine reductase Homo sapiens 413-439 5289368-3 1971 This system has several important characteristics: (a) the rate of dihydroxyphenylalanine formation can be controlled by the concentration of dihydropteridine reductase; (b) low concentrations of catecholamines (2 x 10(-5) M) can produce a marked inhibition of tyrosine hydroxylase activity; and (c) the catecholamine feedback-inhibition of tyrosine hydroxylase can be antagonized by increasing concentrations of dihydropteridine reductase. Catecholamines 196-209 quinoid dihydropteridine reductase Homo sapiens 413-439 5289368-4 1971 The properties of the in vitro tyrosine hydroxylase-dihydropteridine reductase system suggest that dihydropteridine reductase may have an important role in vivo in the determination of the rates of dihydroxyphenylalanine formation and on the effectiveness of the catecholamine feedback-inhibition of tyrosine hydroxylase activity. Catecholamines 263-276 quinoid dihydropteridine reductase Homo sapiens 52-78 5289368-4 1971 The properties of the in vitro tyrosine hydroxylase-dihydropteridine reductase system suggest that dihydropteridine reductase may have an important role in vivo in the determination of the rates of dihydroxyphenylalanine formation and on the effectiveness of the catecholamine feedback-inhibition of tyrosine hydroxylase activity. Catecholamines 263-276 quinoid dihydropteridine reductase Homo sapiens 99-125 5289372-6 1971 Study of DOPA decarboxylase activity in erythrocytes may be useful in following changes in patients receiving DOPA therapy and may also be of general interest and value in investigations of catecholamine metabolism in man. Catecholamines 190-203 dopa decarboxylase Homo sapiens 9-27 5571428-0 1971 Catecholamine stimulation of brain hexokinase. Catecholamines 0-13 hexokinase 1 Homo sapiens 35-45 5576164-2 1971 The addition of catalase protected all systems, but catalase was only partially protective for 6-hydroxydopamine acting upon catecholamine uptake. Catecholamines 125-138 catalase Rattus norvegicus 52-60 4328014-0 1971 Release of adrenal catecholamines by angiotensin I. Catecholamines 19-33 angiotensinogen Homo sapiens 37-50 5542804-3 1971 Paradoxically, the activity of tyrosine hydroxylase, the enzyme thought to be rate-limiting in catecholamine biosynthesis, was significantly increased in brains from undernourished animals. Catecholamines 95-108 tyrosine hydroxylase Rattus norvegicus 31-51 5533118-0 1970 [Effect of vitamin B15 on the excretion of vanilylamygdalic acid and catecholamines in cardiac ischemia]. Catecholamines 69-83 NADH:ubiquinone oxidoreductase subunit B4 Homo sapiens 19-22 4256397-0 1971 The influence of block and catechol-O-methyl transferase on the sensitivity of isolated organs to catecholamines. Catecholamines 98-112 catechol-O-methyltransferase Homo sapiens 27-56 4257153-0 1971 Functional and biochemical effects of d-and 1-amphetamine on central catecholamine neurons. Catecholamines 69-82 NBL1, DAN family BMP antagonist Homo sapiens 38-45 4394154-0 1970 Observations on the mechanism of renin release by catecholamines. Catecholamines 50-64 renin Homo sapiens 33-38 4320467-0 1970 Adenyl cyclase of cultured mammalian cells: activation by catecholamines. Catecholamines 58-72 adenylate cyclase 1 Homo sapiens 0-14 4925252-0 1970 [Effect of a beta-blocking drug on the functional changes in the repolarization phase of the electrocardiogram and on the catecholamine excretion]. Catecholamines 122-135 amyloid beta precursor protein Homo sapiens 11-17 4325764-1 1970 The actions of synthetic angiotensin II on adrenal and myocardial catecholamines. Catecholamines 66-80 angiotensinogen Homo sapiens 25-39 4318481-0 1970 Inhibition by catecholamines of the induction of rat liver glucokinase. Catecholamines 14-28 glucokinase Rattus norvegicus 59-70 4916534-0 1970 Effect of catecholamines precursors on insulin secretion. Catecholamines 10-24 insulin Homo sapiens 39-46 4394605-0 1970 The effects of Ca++ ions on the C14-catecholamine biosynthesis from C14-tyrosine in slices from the striatum of rats. Catecholamines 36-49 anti-Mullerian hormone receptor type 2 Rattus norvegicus 32-35 4394605-0 1970 The effects of Ca++ ions on the C14-catecholamine biosynthesis from C14-tyrosine in slices from the striatum of rats. Catecholamines 36-49 anti-Mullerian hormone receptor type 2 Rattus norvegicus 68-71 4317724-0 1970 [Release of catecholamines from the adrenal gland by bradykinin]. Catecholamines 12-26 kininogen 1 Homo sapiens 53-63 5422431-1 1970 One patient with benign and another with malignant pheochromocytoma have been studied in an attempt to elucidate the effect of increased catecholamines on the response of blood sugar, unesterified fatty acids, insulin and growth hormone to a glucose load. Catecholamines 137-151 growth hormone 1 Homo sapiens 222-236 5422431-2 1970 The presence of increased catecholamines in both patients appeared to produce increased fasting plasma unesterified fatty acid levels, carbohydrate intolerance and an unusual plasma growth hormone response to glucose. Catecholamines 26-40 growth hormone 1 Homo sapiens 182-196 5474394-0 1970 [Changes in urinary catecholamines and vanilmandelic acid under the influence of insulin in patients with hyperestrogenism]. Catecholamines 20-34 insulin Homo sapiens 81-88 4307915-1 1969 Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-beta-hydroxylase activity and the catecholamine content of the storage vesicle fraction. Catecholamines 24-38 insulin Oryctolagus cuniculus 105-112 5420607-5 1970 This suppression of insulin secretion is probably due to the reduced blood flow to the pancreas together with a high level of circulating catecholamines. Catecholamines 138-152 insulin Homo sapiens 20-27 5482108-0 1970 Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Catecholamines 57-71 prolactin Homo sapiens 0-9 5482108-0 1970 Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Catecholamines 57-71 growth hormone 1 Homo sapiens 14-28 5482108-0 1970 Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Catecholamines 101-115 prolactin Homo sapiens 0-9 5482108-0 1970 Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Catecholamines 101-115 growth hormone 1 Homo sapiens 14-28 5800291-0 1969 Inhibition of insulin secretion by catecholamines in pheochromocytoma. Catecholamines 35-49 insulin Homo sapiens 14-21 4318385-0 1970 Effect of adrenocorticotropic hormone and corticosteroid on release of catecholamine from adrenal medulla. Catecholamines 71-84 proopiomelanocortin Homo sapiens 10-37 5523319-0 1970 Effect of growth hormone on urinary excretion of catecholamines in man. Catecholamines 49-63 growth hormone 1 Homo sapiens 10-24 5409444-0 1970 Catecholamine inhibition of prolactin secretion by isolated rat adenohypophyses. Catecholamines 0-13 prolactin Rattus norvegicus 28-37 5818077-0 1969 Influence of norepinephrine and catecholamine-depleting agents on the synthesis and release of prolactin and growth hormone. Catecholamines 32-45 prolactin Homo sapiens 95-104 5818077-0 1969 Influence of norepinephrine and catecholamine-depleting agents on the synthesis and release of prolactin and growth hormone. Catecholamines 32-45 growth hormone 1 Homo sapiens 109-123 4307915-1 1969 Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-beta-hydroxylase activity and the catecholamine content of the storage vesicle fraction. Catecholamines 24-38 dopamine beta-hydroxylase Oryctolagus cuniculus 143-168 4307915-1 1969 Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-beta-hydroxylase activity and the catecholamine content of the storage vesicle fraction. Catecholamines 24-37 insulin Oryctolagus cuniculus 105-112 4307915-1 1969 Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-beta-hydroxylase activity and the catecholamine content of the storage vesicle fraction. Catecholamines 24-37 dopamine beta-hydroxylase Oryctolagus cuniculus 143-168 4307915-2 1969 After sedimentation through a sucrose density gradient, the storage vesicles obtained from insulin-treated animals had the same density and the same ratio of dopamine-beta-hydroxylase to catecholamine as did vesicles from untreated animals. Catecholamines 187-200 insulin Oryctolagus cuniculus 91-98 4299220-0 1968 Inhibition of insulin release by diazoxide and its relation to catecholamine effects in man. Catecholamines 63-76 insulin Homo sapiens 14-21 5812339-0 1969 [On the effect of catecholamines on synthesis and secretion of oxytocin]. Catecholamines 18-32 oxytocin/neurophysin I prepropeptide Homo sapiens 63-71 5726781-0 1968 The effects of drugs inhibiting catecholamine uptake on tyramine and noradrenaline-induced contractions of the isolated rat vas deferens. Catecholamines 32-45 arginine vasopressin Rattus norvegicus 124-127 5653218-1 1968 The influence of catecholamines on growth hormone secretion has been difficult to establish previously, possibly because of the suppressive effect of the induced hyperglycemia on growth hormone concentrations. Catecholamines 17-31 growth hormone 1 Homo sapiens 35-49 4305919-0 1968 [Studies on the effect of angiotensin II on catecholamine metabolism in man]. Catecholamines 44-57 angiotensinogen Homo sapiens 26-40 4378153-0 1967 [The effect of sulfonyl urea, ACTH, and Metopirone on the end products of catecholamine metabolism in diabetes mellitus]. Catecholamines 74-87 proopiomelanocortin Homo sapiens 30-34 5670199-0 1968 [Effect of radon inhalation in Swieradow spa on the urinary excretion of catecholamines in arterial hypertension]. Catecholamines 73-87 surfactant protein A2 Homo sapiens 41-44 5637142-9 1968 These data support the hypothesis that catecholamine blocks the cellular mechanism of vasopressin antidiuresis in vivo. Catecholamines 39-52 arginine vasopressin Homo sapiens 86-97 4228721-0 1967 The role of ATP and ATPase in the release of catecholamines from the adrenal medulla. Catecholamines 45-59 dynein axonemal heavy chain 8 Homo sapiens 20-26 6059520-0 1967 Effect of catecholamines on platelet aggregation caused by thrombin. Catecholamines 10-24 coagulation factor II, thrombin Homo sapiens 59-67 6059871-0 1967 The role of ATP and ATPase in the release of catecholamines from the adrenal medulla. Catecholamines 45-59 dynein axonemal heavy chain 8 Homo sapiens 20-26 4888262-0 1967 [The activity of acetylcholinesterase in the blood and elimination of catecholamines in the urine in patients with peptic ulcer before and after stomach resection and in the dumping syndrome]. Catecholamines 70-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 4385417-0 1967 [Interaction among anti-MAO and adreno-medullary catecholamines. Catecholamines 49-63 monoamine oxidase A Rattus norvegicus 24-27 6056695-0 1967 [Interaction between anti-MAO and adrenomedullary catecholamines. Catecholamines 50-64 monoamine oxidase A Rattus norvegicus 26-29 4285012-0 1965 Effects of infusion of catecholamines and angiotensin II on renin release in anesthetized dogs. Catecholamines 23-37 renin Canis lupus familiaris 60-65 4290712-0 1967 Stimulation of the catecholamine output of the isolated, perfused adrenal gland of the dog by angiotensin and bradykinin. Catecholamines 19-32 kininogen 1 Canis lupus familiaris 110-120 5938420-1 1966 Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine synthesis. Catecholamines 52-65 tyrosine hydroxylase Rattus norvegicus 0-20 6021207-2 1967 Despite concurrent increases in arterial blood pressure, the plasma renin activity of normal subjects increased both in response to the infusion of catecholamines (norepinephrine: epinephrine, 10:1) and in response to stimulation of the sympathetic nervous system by cold. Catecholamines 148-162 renin Homo sapiens 68-73 6021207-6 1967 When orthostatic hypotension was prevented by infusion of catecholamines, however, increases in plasma renin activity and in aldosterone excretion were observed. Catecholamines 58-72 renin Homo sapiens 103-108 5922312-0 1966 The influence of the dopa decarboxylase inhibitor Ro4-4602 on the urinary excretion of catecholamines in cold-stressed rats. Catecholamines 87-101 dopa decarboxylase Rattus norvegicus 21-39 4952963-4 1965 The biochemical effects of these drugs will involve several substrates of MAO, e.g. dopamine, tyramine, serotonin and, to a lesser extent, noradrenaline and adrenaline.MAO probably regulates the metabolism of catecholamines and serotonin in tissues, while catechol-O-methyltransferase is responsible for the metabolism of circulating noradrenaline and adrenaline.Certain pharmacological effects of MAOI are related to the accumulation of monoamines in various tissues that follows the decrease of intraneuronal deamination. Catecholamines 209-223 catechol-O-methyltransferase Homo sapiens 256-284 4955040-0 1965 [Action of catecholamines on cytochrome C]. Catecholamines 11-25 cytochrome c, somatic Homo sapiens 29-41 5890420-0 1965 [On catecholamine liberation by means of thrombin]. Catecholamines 4-17 coagulation factor II, thrombin Homo sapiens 41-49 14263843-0 1964 [EFFECT OF CATECHOLAMINE OXIDATION PRODUCTS ON THE ATPASE ACTIVITY OF MYOSIN]. Catecholamines 11-24 myosin heavy chain 14 Homo sapiens 70-76 14004499-0 1961 Oxidation of reduced phosphopyridine nucleotides by p-phenylenediamines, catecholamines and serotonin in the presence of ceruloplasmin. Catecholamines 73-87 ceruloplasmin Homo sapiens 121-134 14109609-0 1963 [INFLUENCE OF NETHALIDE (2-ISOPROPYLAMINO-1-(2-NAPHTHYL)-ETHANOL HC1) ON THE ACTION EXERCISED BY CATECHOLAMINES ON THE CORONARY CIRCULATION AND ON THE INOTROPIC PROPERTIES OF THE MAMMALIAN HEART]. Catecholamines 98-112 CYCS pseudogene 39 Homo sapiens 66-69 13986533-2 1963 Cytochrome c action in vivo and relation to catecholamine and serotonin metabolism]. Catecholamines 44-57 cytochrome c, somatic Homo sapiens 0-12 14033174-2 1963 On the action of ATP in vivo and its relation to catecholamine and serotonin metabolism]. Catecholamines 49-62 ATPase phospholipid transporting 8A2 Homo sapiens 17-20 13998406-0 1963 Siectrophotometric and electron-spin resonance studies of complexes of catecholamines with Cu(II) ions and the interaction of ceruloplasmin with catecholamines. Catecholamines 145-159 ceruloplasmin Homo sapiens 126-139 13962157-0 1963 [Effect of vasopressin on adrenal catecholamine secretion]. Catecholamines 34-47 arginine vasopressin Homo sapiens 11-22 14125818-0 1963 [THE BLOOD CATECHOLAMINE LEVEL OF MENTAL PATIENTS AND ITS CHANGES UNDER THE INFLUENCE OF AMINAZIN AND INSULIN]. Catecholamines 11-24 insulin Homo sapiens 102-110 14480963-0 1962 [The relation of the hyperglycemic effect of BAL and BAL with insulin on the liberation of catecholamine from the adrenal medulla]. Catecholamines 91-104 poly(ADP-ribose) polymerase family member 9 Homo sapiens 45-48 14480963-0 1962 [The relation of the hyperglycemic effect of BAL and BAL with insulin on the liberation of catecholamine from the adrenal medulla]. Catecholamines 91-104 poly(ADP-ribose) polymerase family member 9 Homo sapiens 53-56 13783908-0 1960 The effect of insulin on the catecholamines and adenine nucleotides of adrenal glands. Catecholamines 29-43 insulin Homo sapiens 14-21 14480963-0 1962 [The relation of the hyperglycemic effect of BAL and BAL with insulin on the liberation of catecholamine from the adrenal medulla]. Catecholamines 91-104 insulin Homo sapiens 62-69 13713740-0 1960 Influence of muscular training and of catecholamines on cardiac acetylcholine and cholinesterase. Catecholamines 38-52 butyrylcholinesterase Homo sapiens 82-96 33851554-6 2021 Notably, we found that such insulin-suppressing effects on catecholamine-induced constriction are diminished following beta-adrenergic receptor blockade. Catecholamines 59-72 insulin Homo sapiens 28-35 14919100-0 1952 Excretion of catechol amines during administration of ACTH, cortisone and desoxycorticosterone acetate. Catecholamines 13-28 proopiomelanocortin Homo sapiens 54-58 13662376-0 1959 [Insulin- and reserpine-induced changes of the content of catecholamine, ascorbic acid and cholesterol of the adrenal with or without iproniazid pretreatment]. Catecholamines 58-71 insulin Homo sapiens 1-8 34010646-5 2021 Mechanistically, inhibition of forkhead box O1 (FOXO1) by AKT controls BAT thermogenesis by enhancing catecholamine-induced lipolysis in the white adipose tissue (WAT) and increasing circulating fibroblast growth factor 21 (FGF21). Catecholamines 102-115 forkhead box O1 Homo sapiens 31-46 34001616-8 2021 This system allows for the addressing of central unresolved issues in the beta-AR-CaV1.2 cascade and will facilitate the development of therapies for catecholamine-induced cardiac pathologies. Catecholamines 150-163 calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog Xenopus laevis 82-88 34010646-5 2021 Mechanistically, inhibition of forkhead box O1 (FOXO1) by AKT controls BAT thermogenesis by enhancing catecholamine-induced lipolysis in the white adipose tissue (WAT) and increasing circulating fibroblast growth factor 21 (FGF21). Catecholamines 102-115 forkhead box O1 Homo sapiens 48-53 34010646-5 2021 Mechanistically, inhibition of forkhead box O1 (FOXO1) by AKT controls BAT thermogenesis by enhancing catecholamine-induced lipolysis in the white adipose tissue (WAT) and increasing circulating fibroblast growth factor 21 (FGF21). Catecholamines 102-115 AKT serine/threonine kinase 1 Homo sapiens 58-61 33994373-1 2021 Fetuses with intrauterine growth restriction (IUGR) have high concentrations of catecholamines, which lowers the insulin secretion and glucose uptake. Catecholamines 80-94 LOC105613195 Ovis aries 113-120 33999297-9 2021 Central alpha-2 agonists have been shown to prevent peripheral adrenergic receptor desensitization by reducing catecholamine exposure. Catecholamines 111-124 glycoprotein hormone subunit alpha 2 Homo sapiens 8-15 34035894-0 2021 Associations between plasma levels of C-reactive protein and catecholamine metabolites in patients with major depression. Catecholamines 61-74 C-reactive protein Homo sapiens 38-56 33987762-4 2021 Most studies of catecholamine clearance have focused on the presynaptic high-affinity, low-capacity dopamine (DAT), and norepinephrine (NET) transporters, which are members of the uptake1 family of monoamine transporters. Catecholamines 16-29 solute carrier family 6 member 3 Homo sapiens 110-113 33987762-6 2021 In contrast to DAT and NET, these transporters have higher capacity and lower affinity for catecholamines and are multi-specific, each with the capacity to transport all catecholamines. Catecholamines 91-105 solute carrier family 6 member 3 Homo sapiens 15-18 33987762-6 2021 In contrast to DAT and NET, these transporters have higher capacity and lower affinity for catecholamines and are multi-specific, each with the capacity to transport all catecholamines. Catecholamines 170-184 solute carrier family 6 member 3 Homo sapiens 15-18 33987762-8 2021 This review summarizes studies describing the anatomical distribution of OCT2, OCT3, and PMAT, their cellular and subcellular localization, and their contribution to the regulation of the clearance of catecholamines in the brain. Catecholamines 201-215 solute carrier family 22 member 2 Homo sapiens 73-77 33987762-8 2021 This review summarizes studies describing the anatomical distribution of OCT2, OCT3, and PMAT, their cellular and subcellular localization, and their contribution to the regulation of the clearance of catecholamines in the brain. Catecholamines 201-215 solute carrier family 29 member 4 Homo sapiens 89-93 33991113-0 2021 Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo. Catecholamines 98-111 tyrosine hydroxylase Mus musculus 9-29 33093660-4 2021 Structural comparison revealed that the catecholamine-binding pockets are identical between beta1AR and beta2AR, but the extracellular vestibules have different shapes and electrostatic properties. Catecholamines 40-53 adrenoceptor beta 1 Homo sapiens 92-99 34017842-4 2021 Since the half-life of vasopressin is longer than that of catecholamines, we hypothesized that vasopressin loading may be effective for predicting responses to its continuous administration. Catecholamines 58-72 arginine vasopressin Homo sapiens 95-106 33992806-1 2022 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in catecholamine (CA) biosynthesis pathway making TH a molecular target for controlling CA production, specifically dopamine. Catecholamines 62-75 tyrosine hydroxylase Homo sapiens 0-20 33992806-1 2022 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in catecholamine (CA) biosynthesis pathway making TH a molecular target for controlling CA production, specifically dopamine. Catecholamines 62-75 tyrosine hydroxylase Homo sapiens 22-24 33992806-1 2022 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in catecholamine (CA) biosynthesis pathway making TH a molecular target for controlling CA production, specifically dopamine. Catecholamines 62-75 tyrosine hydroxylase Homo sapiens 109-111 33938370-1 2022 Catestatin can inhibit catecholamine release from chromaffin cells and adrenergic neurons. Catecholamines 23-36 chromogranin A Homo sapiens 0-10 33887543-2 2021 The dopamine transporter gene (SLC6A3) is involved in the metabolism of dopamine and catecholamine and is a potential gene for Parkinson"s disease and alcoholism. Catecholamines 85-98 solute carrier family 6 member 3 Homo sapiens 31-37 33887543-2 2021 The dopamine transporter gene (SLC6A3) is involved in the metabolism of dopamine and catecholamine and is a potential gene for Parkinson"s disease and alcoholism. Catecholamines 85-98 solute carrier family 6 member 3 Homo sapiens 4-24 33722543-1 2021 ErbB4 loss-of-function in catecholaminergic neurons induces catecholamine dyshomeostasis. Catecholamines 26-39 erb-b2 receptor tyrosine kinase 4 Homo sapiens 0-5 33929344-1 2021 PURPOSE OF REVIEW: Cardiogenic shock (CS) therapy involving catecholamines, inotropes, fluids and revascularization is often insufficient, and short-term mortality remains 50%. Catecholamines 60-74 citrate synthase Homo sapiens 38-40 33722543-3 2021 In this study, we attempt to identify the downstream pathway of ErbB4 that regulates catecholamine homeostasis. Catecholamines 85-98 erb-b2 receptor tyrosine kinase 4 Homo sapiens 64-69 33722543-5 2021 Western blotting, enzyme-linked immunosorbent assay, and pharmacological and genetic manipulations by agonist/antagonist or small interference RNA were used to investigate the relationship between ErbB4 and extracellular catecholamines. Catecholamines 221-235 erb-b2 receptor tyrosine kinase 4 Homo sapiens 197-202 33664131-7 2021 Introduction of a syp construct lacking its C-terminal dynamin-binding domain in syp knock-outs increased the duration and fraction of kiss-and-run events, increased total catecholamine release per event, and reduced late-stage fusion pore expansion. Catecholamines 172-185 synaptophysin Mus musculus 81-84 33892492-11 2022 Further, we have shown that cardiomyocyte-expressed EGFR is required for the promotion of cardiac hypertrophy under conditions of chronic catecholamine stress. Catecholamines 138-151 epidermal growth factor receptor Homo sapiens 52-56 33536201-12 2021 We map and quantify expression of tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis, in the entire cerebellar system, including several precerebellar nuclei. Catecholamines 89-102 tyrosine hydroxylase Mus musculus 56-58 33981424-12 2021 Conclusions: Vasopressin could be an option for treating hypotension secondary to ARB and CCB toxicity when catecholamines and treatment for CCB toxicity fail. Catecholamines 108-122 arginine vasopressin Homo sapiens 13-24 33664131-7 2021 Introduction of a syp construct lacking its C-terminal dynamin-binding domain in syp knock-outs increased the duration and fraction of kiss-and-run events, increased total catecholamine release per event, and reduced late-stage fusion pore expansion. Catecholamines 172-185 synaptophysin Mus musculus 18-21 33923958-7 2021 Besides pro-inflammatory cytokines that are well-known to initiate the retrodifferentiation process, the release of catecholamines in the microenvironment of the tumor can modulate both EMT and metabolic changes in cancer cells through the activation of EMT transcription factors (ZEB1, Snail, or Slug (SNAI2)). Catecholamines 116-130 zinc finger E-box binding homeobox 1 Homo sapiens 281-285 33923958-7 2021 Besides pro-inflammatory cytokines that are well-known to initiate the retrodifferentiation process, the release of catecholamines in the microenvironment of the tumor can modulate both EMT and metabolic changes in cancer cells through the activation of EMT transcription factors (ZEB1, Snail, or Slug (SNAI2)). Catecholamines 116-130 snail family transcriptional repressor 1 Homo sapiens 287-292 33923958-7 2021 Besides pro-inflammatory cytokines that are well-known to initiate the retrodifferentiation process, the release of catecholamines in the microenvironment of the tumor can modulate both EMT and metabolic changes in cancer cells through the activation of EMT transcription factors (ZEB1, Snail, or Slug (SNAI2)). Catecholamines 116-130 snail family transcriptional repressor 2 Homo sapiens 297-301 33923958-7 2021 Besides pro-inflammatory cytokines that are well-known to initiate the retrodifferentiation process, the release of catecholamines in the microenvironment of the tumor can modulate both EMT and metabolic changes in cancer cells through the activation of EMT transcription factors (ZEB1, Snail, or Slug (SNAI2)). Catecholamines 116-130 snail family transcriptional repressor 2 Homo sapiens 303-308 33536201-15 2021 Finally, we show that inhibition of excitatory LCN neurons with DREADDs, designed to mimic Gi-coupled catecholamine GPCR signaling, results in facilitation of a working memory task impaired in LCN-specific TH knockout mice. Catecholamines 102-115 tyrosine hydroxylase Mus musculus 206-208 33657384-6 2021 Strikingly, EODF treatment downregulates lipolysis specifically in vWAT, mediated by a large decrease in the abundance of the catecholamine receptor (ADRB3). Catecholamines 126-139 adrenergic receptor, beta 3 Mus musculus 150-155 33309753-1 2021 Tyrosine hydroxylase (TH) catalyses the (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4)-dependent conversion of l-tyrosine to L-3,4-dihydroxyphenylalanine (l-Dopa), which is the rate-limiting step in the synthesis of dopamine and other catecholamine neurotransmitters and hormones. Catecholamines 237-250 tyrosine hydroxylase Homo sapiens 0-20 33309753-1 2021 Tyrosine hydroxylase (TH) catalyses the (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4)-dependent conversion of l-tyrosine to L-3,4-dihydroxyphenylalanine (l-Dopa), which is the rate-limiting step in the synthesis of dopamine and other catecholamine neurotransmitters and hormones. Catecholamines 237-250 tyrosine hydroxylase Homo sapiens 22-24 33689182-6 2021 Chronic treatment of mice with either catecholamines or doxorubicin increased CR9 activity during the progression of cardiac hypertrophy to failure, which is accompanied by proportional increases in Nppb expression. Catecholamines 38-52 natriuretic peptide type B Mus musculus 199-203 33689182-9 2021 Furthermore, the enhancement of CR9 activity and Nppa and Nppb expressions by either catecholamines or mechanical loads can be blunted by suppressing mechanosensing and mechanotransduction pathways, such as muscle LIM protein (MLP) or myosin tension. Catecholamines 85-99 natriuretic peptide type A Mus musculus 49-53 33689182-9 2021 Furthermore, the enhancement of CR9 activity and Nppa and Nppb expressions by either catecholamines or mechanical loads can be blunted by suppressing mechanosensing and mechanotransduction pathways, such as muscle LIM protein (MLP) or myosin tension. Catecholamines 85-99 natriuretic peptide type B Mus musculus 58-62 33538833-4 2021 Our laboratory has previously shown that reduced VMAT2 activity confers vulnerability on catecholamine neurons in mice. Catecholamines 89-102 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 49-54 33635165-11 2021 Biased APJ signaling toward Galphai over the beta-arrestin pathway offer a promising strategy in the treatment of cardiovascular diseases related to myocardial hypertrophy and high catecholamine levels. Catecholamines 181-194 apelin receptor Rattus norvegicus 7-10 33755985-2 2021 Angiotensin I Converting Enzyme 2 (ACE2), the principal receptor of SARS-CoV2, has been found to be communicated with Dopa decarboxylase in unwinding the connection of catecholamines with COVID-19 infection. Catecholamines 168-182 angiotensin converting enzyme 2 Homo sapiens 0-33 33481407-13 2021 beta1- and beta2-adrenergic receptor antagonists reduced the effects of the catecholamines on transendothelial resistance, whereas alpha-adrenergic receptor antagonists did not. Catecholamines 76-90 adrenoceptor beta 1 Homo sapiens 0-36 33755985-2 2021 Angiotensin I Converting Enzyme 2 (ACE2), the principal receptor of SARS-CoV2, has been found to be communicated with Dopa decarboxylase in unwinding the connection of catecholamines with COVID-19 infection. Catecholamines 168-182 angiotensin converting enzyme 2 Homo sapiens 35-39 33755985-2 2021 Angiotensin I Converting Enzyme 2 (ACE2), the principal receptor of SARS-CoV2, has been found to be communicated with Dopa decarboxylase in unwinding the connection of catecholamines with COVID-19 infection. Catecholamines 168-182 dopa decarboxylase Homo sapiens 118-136 33755985-6 2021 Catecholamine biosynthesis is managed by counter-controlling angiotensin type 1R (AT1R) and angiotensin type 2R (AT2R), incitement of AT2 lessens catecholamine biosynthesis by means of a diminishing in cGMP levels likewise incitement of AT1 initiate catecholamine biosynthesis. Catecholamines 0-13 angiotensin II receptor type 1 Homo sapiens 82-86 33755985-6 2021 Catecholamine biosynthesis is managed by counter-controlling angiotensin type 1R (AT1R) and angiotensin type 2R (AT2R), incitement of AT2 lessens catecholamine biosynthesis by means of a diminishing in cGMP levels likewise incitement of AT1 initiate catecholamine biosynthesis. Catecholamines 250-263 angiotensin II receptor type 1 Homo sapiens 82-86 32929770-13 2021 CONCLUSION: We introduced a method that can resolve Pi using 7 Tesla STEAM 31 P-MRS. We demonstrate the stability of Pi/PCr and myocardial pH in volunteers at rest and during catecholamine stress. Catecholamines 175-188 phenylalanine hydroxylase Homo sapiens 139-141 33564118-12 2021 These findings suggest that circulating catecholamines can stimulate metabolism in people with CSCI despite the presence of autonomic dysfunction. Catecholamines 40-54 CSCI Homo sapiens 95-99 33664495-2 2021 However, whether there exists a direct effector that physically connects catecholamine signalling to UCP1 in response to acute cold is unknown. Catecholamines 73-86 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 101-105 33671654-2 2021 We assessed whether S1P had multiplex effects in regulating the large-conductance Ca2+-activated K+ channel (BKCa) in catecholamine-secreting chromaffin cells. Catecholamines 118-131 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 109-113 33068897-1 2021 Tyrosinase (TYR) is a crucial enzyme in melanin metabolism and catecholamine production, its abnormal overexpression is closely associated with many human diseases involving melanoma cancer, vitiligo, Parkinson"s disease and so on. Catecholamines 63-76 tyrosinase Homo sapiens 0-10 33578719-4 2021 Renalase metabolises catecholamines and therefore may be involved in the pathogenesis of hypertension and other diseases of the circulatory system. Catecholamines 21-35 renalase, FAD dependent amine oxidase Homo sapiens 0-8 33578719-11 2021 The decreased plasma concentrations of catecholamines may be due to their increased degradation by plasma renalase. Catecholamines 39-53 renalase, FAD dependent amine oxidase Homo sapiens 106-114 33068897-1 2021 Tyrosinase (TYR) is a crucial enzyme in melanin metabolism and catecholamine production, its abnormal overexpression is closely associated with many human diseases involving melanoma cancer, vitiligo, Parkinson"s disease and so on. Catecholamines 63-76 tyrosinase Homo sapiens 12-15 33536282-1 2021 Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ventricular ectopy in response to catecholamine stress, which can be reproduced on exercise stress testing (EST). Catecholamines 67-80 ryanodine receptor 2, cardiac Mus musculus 28-32 33538092-3 2021 Here, we report our studies on the role of Tyrosine decarboxylase 2 (Tdc2), which converts tyrosine to the catecholamine tyramine, in glial cells in Drosophila alcohol sedation. Catecholamines 107-120 Tyrosine decarboxylase 2 Drosophila melanogaster 43-67 33538092-3 2021 Here, we report our studies on the role of Tyrosine decarboxylase 2 (Tdc2), which converts tyrosine to the catecholamine tyramine, in glial cells in Drosophila alcohol sedation. Catecholamines 107-120 Tyrosine decarboxylase 2 Drosophila melanogaster 69-73 33522899-9 2021 As the NR4A3 could regulate the catecholamine catabolism, which could affect insulin sensitivity, we inferred that IRLnc influence IMF decomposition by regulating the expression of NR4A3. Catecholamines 32-45 nuclear receptor subfamily 4 group A member 3 Homo sapiens 7-12 33275531-1 2021 Alpha-1-Adrenergic receptors (ARs) are catecholamine-activated G protein-coupled receptors (GPCRs) that are expressed in mouse and human myocardium and vasculature and play essential roles in the regulation of cardiovascular physiology. Catecholamines 39-52 BCL2 related protein A1 Homo sapiens 0-7 33341043-4 2021 Catestatin is a bioactive peptide with 21 amino acids, which is derived through cleaving of the prohormone chromogranin A (CHGA/CgA) that is co-released with catecholamines from secretory vesicles and, which is responsible for hepatic/plasma lipids and insulin levels regulation, improves insulin sensitivity, reduces hypertension and attenuates obesity in murine models. Catecholamines 158-172 chromogranin A Homo sapiens 0-10 33341043-4 2021 Catestatin is a bioactive peptide with 21 amino acids, which is derived through cleaving of the prohormone chromogranin A (CHGA/CgA) that is co-released with catecholamines from secretory vesicles and, which is responsible for hepatic/plasma lipids and insulin levels regulation, improves insulin sensitivity, reduces hypertension and attenuates obesity in murine models. Catecholamines 158-172 chromogranin A Mus musculus 107-121 33341043-4 2021 Catestatin is a bioactive peptide with 21 amino acids, which is derived through cleaving of the prohormone chromogranin A (CHGA/CgA) that is co-released with catecholamines from secretory vesicles and, which is responsible for hepatic/plasma lipids and insulin levels regulation, improves insulin sensitivity, reduces hypertension and attenuates obesity in murine models. Catecholamines 158-172 chromogranin A Mus musculus 123-127 33341043-4 2021 Catestatin is a bioactive peptide with 21 amino acids, which is derived through cleaving of the prohormone chromogranin A (CHGA/CgA) that is co-released with catecholamines from secretory vesicles and, which is responsible for hepatic/plasma lipids and insulin levels regulation, improves insulin sensitivity, reduces hypertension and attenuates obesity in murine models. Catecholamines 158-172 chromogranin A Mus musculus 128-131 33522899-9 2021 As the NR4A3 could regulate the catecholamine catabolism, which could affect insulin sensitivity, we inferred that IRLnc influence IMF decomposition by regulating the expression of NR4A3. Catecholamines 32-45 insulin Homo sapiens 77-84 33522899-9 2021 As the NR4A3 could regulate the catecholamine catabolism, which could affect insulin sensitivity, we inferred that IRLnc influence IMF decomposition by regulating the expression of NR4A3. Catecholamines 32-45 nuclear receptor subfamily 4 group A member 3 Homo sapiens 181-186 33448546-6 2021 F1-7 and F34-3 induced CGA expression, increased catecholamine secretion, and activated the CGA/alpha2A adrenoreceptor (ADRalpha2A) cascade signal in ECs. Catecholamines 49-62 coagulation factor V Mus musculus 0-4 33280407-12 2021 Further, in correlation matrix analysis, higher 24-hour urinary catecholamines and metanephrines were associated with higher 24-hour urinary aldosterone and plasma renin activity levels in MUCH patients. Catecholamines 64-78 renin Homo sapiens 164-169 32583430-4 2021 Then, western blots, enzyme-linked immunosorbent assay, immunofluorescence, quantitative polymerase chain reaction and pathway analysis were conducted to analyze the role of Bag5 in endothelial cell damage in response to catecholamine. Catecholamines 221-234 BAG cochaperone 5 Homo sapiens 174-178 32583430-7 2021 Mechanistically, Bag5 overexpression inhibited ER stress, attenuated oxidative stress and repressed inflammation in catecholamine-treated endothelial cells. Catecholamines 116-129 BAG cochaperone 5 Homo sapiens 17-21 32583430-11 2021 Altogether, our results illustrate that Bag5 overexpression sustains endothelial cell survival in response to catecholamine treatment. Catecholamines 110-123 BAG cochaperone 5 Homo sapiens 40-44 32583430-12 2021 This finding identifies Bag5 downregulation and the inactivated MAPK-ERK pathway as potential mechanisms underlying catecholamine-induced endothelial cell damage. Catecholamines 116-129 BAG cochaperone 5 Homo sapiens 24-28 32583430-12 2021 This finding identifies Bag5 downregulation and the inactivated MAPK-ERK pathway as potential mechanisms underlying catecholamine-induced endothelial cell damage. Catecholamines 116-129 mitogen-activated protein kinase 1 Homo sapiens 69-72 33491666-6 2021 Catecholamine biosynthesis pathways were reduced in mINDY-KO adrenals using unbiased microarray analysis. Catecholamines 0-13 solute carrier family 13 (sodium-dependent citrate transporter), member 5 Mus musculus 52-57 33491666-8 2021 Our data suggest that deletion of mIndy reduces sympathoadrenal support of BP and HR by attenuating catecholamine biosynthesis. Catecholamines 100-113 solute carrier family 13 (sodium-dependent citrate transporter), member 5 Mus musculus 34-39 32583430-0 2021 Bcl-2-associated athanogene 5 overexpression attenuates catecholamine-induced vascular endothelial cell apoptosis. Catecholamines 56-69 BAG cochaperone 5 Homo sapiens 0-29 33183171-13 2021 Activation of these intracellular beta1ARs requires catecholamine transport via OCT3. Catecholamines 52-65 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 80-84 33220286-9 2021 The blocking of VIP signaling produces changes in ovarian catecholamines. Catecholamines 58-72 vasoactive intestinal peptide Rattus norvegicus 16-19 33437193-2 2021 Tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) are two of the main enzymes of catecholamines (CA) synthesis. Catecholamines 107-121 tyrosine hydroxylase Homo sapiens 0-20 33451134-5 2021 Noradrenergic modulation of estrogen receptor (ER) control of VMN glycogen phosphorylase (GP) isoform expression supports the interaction of catecholamine and estradiol signals in shaping the physiological stimulus-specific control of astrocyte glycogen mobilization. Catecholamines 141-154 estrogen receptor 1 Homo sapiens 47-49 33451134-5 2021 Noradrenergic modulation of estrogen receptor (ER) control of VMN glycogen phosphorylase (GP) isoform expression supports the interaction of catecholamine and estradiol signals in shaping the physiological stimulus-specific control of astrocyte glycogen mobilization. Catecholamines 141-154 ring finger protein 130 Homo sapiens 90-92 33168470-4 2021 It appears that TTS is induced by aberrant post-beta2-adrenoceptor signalling in the setting of "surge" release of catecholamines. Catecholamines 115-129 adrenoceptor beta 2 Homo sapiens 48-66 33437193-2 2021 Tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) are two of the main enzymes of catecholamines (CA) synthesis. Catecholamines 107-121 tyrosine hydroxylase Homo sapiens 22-24 33437193-2 2021 Tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) are two of the main enzymes of catecholamines (CA) synthesis. Catecholamines 107-121 phenylethanolamine N-methyltransferase Homo sapiens 30-68 33437193-2 2021 Tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) are two of the main enzymes of catecholamines (CA) synthesis. Catecholamines 107-121 phenylethanolamine N-methyltransferase Homo sapiens 70-74 33336311-3 2020 Hypo/hypercapnia, as well as mechanical ventilation during and after resuscitation, can affect CO2 levels and trigger a dangerous pathophysiological vicious circle related to the relationship between pH, cellular demand, and catecholamine levels. Catecholamines 225-238 phenylalanine hydroxylase Homo sapiens 200-202 33463901-5 2021 The release of major stress and steroid hormones, catecholamine overload, and glucagon all participate in generating a state of insulin resistance with increased hepatic glucose output and glycogen breakdown. Catecholamines 50-63 insulin Homo sapiens 128-135 33456562-11 2021 In vivo, ILC-deficient Rag2-/-IL2Rgammac-/- mice developed exacerbated cardiac fibrosis following catecholamine-induced stress cardiac injury. Catecholamines 98-111 recombination activating gene 2 Mus musculus 23-27 33456562-11 2021 In vivo, ILC-deficient Rag2-/-IL2Rgammac-/- mice developed exacerbated cardiac fibrosis following catecholamine-induced stress cardiac injury. Catecholamines 98-111 interleukin 2 Mus musculus 30-33 33207866-3 2020 Hence, we study the role of a catecholamine, norepinephrine, on the amyloid aggregation of hIAPP, which has previously displayed inhibitory effect on amyloid-beta aggregation. Catecholamines 30-43 islet amyloid polypeptide Homo sapiens 91-96 33285135-8 2022 Patients with higher copeptin levels, underwent more complex procedures, had longer cardiopulmonary bypass times, required more catecholamine support, needed longer time of invasive ventilation, and had a longer overall stay and ICU stay. Catecholamines 128-141 arginine vasopressin Homo sapiens 21-29 33016185-10 2020 White adipocytes of Cyp8b1-/- mice exhibited increased responsiveness to both catecholamines and insulin in lipolysis experiments and increased insulin-stimulated lipogenesis. Catecholamines 78-92 cytochrome P450, family 8, subfamily b, polypeptide 1 Mus musculus 20-26 33273668-8 2020 Patients referred from HBHs tended to require catecholamine infusion on transfer more often than those referred from LBLs (36.5% (HBH), 20.2% (LBL), P = 0.021). Catecholamines 46-59 hemoglobin subunit alpha 1 Homo sapiens 23-26 32725894-0 2020 Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens. Catecholamines 82-95 OCTN3 Homo sapiens 0-28 33016509-5 2020 Furthermore, nuclear localization of Her2 was significantly correlated with overexpression of beta2-AR in human breast cancer tissues, indicating that catecholamine-induced beta2-AR activation plays decisive roles in tumor metastasis. Catecholamines 151-164 erb-b2 receptor tyrosine kinase 2 Homo sapiens 37-41 33016509-5 2020 Furthermore, nuclear localization of Her2 was significantly correlated with overexpression of beta2-AR in human breast cancer tissues, indicating that catecholamine-induced beta2-AR activation plays decisive roles in tumor metastasis. Catecholamines 151-164 adenosine A2a receptor Homo sapiens 94-102 33016509-5 2020 Furthermore, nuclear localization of Her2 was significantly correlated with overexpression of beta2-AR in human breast cancer tissues, indicating that catecholamine-induced beta2-AR activation plays decisive roles in tumor metastasis. Catecholamines 151-164 adenosine A2a receptor Homo sapiens 173-181 32725894-0 2020 Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens. Catecholamines 82-95 solute carrier family 6 member 3 Homo sapiens 37-57 32725894-4 2020 Previous work has shown that catecholamine clearance in the NAcc is largely mediated by the dopamine transporter (DAT), but clearance in the BLA is less DAT-dependent. Catecholamines 29-42 solute carrier family 6 member 3 Homo sapiens 92-112 32725894-4 2020 Previous work has shown that catecholamine clearance in the NAcc is largely mediated by the dopamine transporter (DAT), but clearance in the BLA is less DAT-dependent. Catecholamines 29-42 solute carrier family 6 member 3 Homo sapiens 114-117 32725894-5 2020 A growing body of literature suggests that organic cation transporter 3 (OCT3) also contributes to catecholamine clearance in both regions. Catecholamines 99-112 OCTN3 Homo sapiens 43-71 32725894-5 2020 A growing body of literature suggests that organic cation transporter 3 (OCT3) also contributes to catecholamine clearance in both regions. Catecholamines 99-112 OCTN3 Homo sapiens 73-77 32725894-7 2020 We compared the expression of DAT and OCT3 and their contributions to catecholamine clearance in the NAcc and BLA. Catecholamines 70-83 solute carrier family 6 member 3 Homo sapiens 30-33 32725894-11 2020 Additionally, catecholamine clearance in the BLA was more sensitive to the OCT3 inhibitor corticosterone, while clearance in the NAcc was more cocaine sensitive. Catecholamines 14-27 OCTN3 Homo sapiens 75-79 32966816-0 2020 Inhibition of the fatty acid amide hydrolase changes behaviours and brain catecholamines in a sex-specific manner in rats exposed to chronic unpredictable stress. Catecholamines 74-88 fatty-acid amide hydrolase-like Rattus norvegicus 18-44 32966816-5 2020 Our findings indicate that the FAAH inhibitor URB597 differently regulated catecholamine levels and its enzymes of synthesis and degradation in the examined brain areas of male and female rats. Catecholamines 75-88 fatty-acid amide hydrolase-like Rattus norvegicus 31-35 33324231-11 2020 The results indicate that (1) acute HIIT can induce an increase of HSL phosphorylation in subcutaneous fat lasting at least 12 h, implying longer post-exercise lipolysis than MICT and (2) long-time HIIT has a better effect on improving catecholamine resistance of visceral adipocytes caused by a HFD, which allows fat to be mobilized more easily when stimulated. Catecholamines 236-249 lipase, hormone sensitive Mus musculus 67-70 33329690-2 2020 EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Catecholamines 15-28 Eph receptor B6 Mus musculus 0-5 33329690-3 2020 Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine secretion by AGCCs. Catecholamines 133-146 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 0-32 33329690-3 2020 Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine secretion by AGCCs. Catecholamines 133-146 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 34-39 33273918-6 2020 Catecholamines play a crucial role in regulating vascular smooth muscle (VSM), airway smooth muscle (ASM), and cardiac muscle (CM) function and tone. Catecholamines 0-14 H19 imprinted maternally expressed transcript Homo sapiens 101-104 33231111-1 2022 INTRODUCTION: Angiotensin II (Ang-2) is a non-catecholamine vasopressor that targets the renin-angiotensin-aldosterone system by agonism of the angiotensin type 1 receptor. Catecholamines 46-59 angiotensinogen Homo sapiens 14-28 33231111-1 2022 INTRODUCTION: Angiotensin II (Ang-2) is a non-catecholamine vasopressor that targets the renin-angiotensin-aldosterone system by agonism of the angiotensin type 1 receptor. Catecholamines 46-59 angiopoietin 2 Homo sapiens 30-35 33231111-10 2022 CONCLUSION: Ang-2 is an effective vasopressor and reduces catecholamine dose significantly. Catecholamines 58-71 angiopoietin 2 Homo sapiens 12-17 33205255-4 2020 The results guided us to investigate the relevance of TRPM4 for catecholamine-evoked Ca2+ signaling in cardiomyocytes and inotropy in vivo in TRPM4-deficient mouse models of different genetic background. Catecholamines 64-77 transient receptor potential cation channel, subfamily M, member 4 Mus musculus 54-59 32031586-9 2020 CONCLUSION: Given that compartmentalized betaAR signaling can be induced by stress-associated levels of catecholamines, our results revealed an important, yet unappreciated, heart regulation mechanism that is autoadaptive to varied stress conditions. Catecholamines 104-118 adrenoceptor beta 1 Homo sapiens 41-47 32866920-2 2020 COMT expression is directedly associated with various mental diseases and cancers due to its essential role in catalyzing metabolic inactivation of endogenous catecholamines and catechol estrogens. Catecholamines 159-173 catechol-O-methyltransferase Homo sapiens 0-4 33158106-3 2020 The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of beta-ARs. Catecholamines 102-116 alanyl-tRNA synthetase 1 Homo sapiens 181-189 32609011-0 2020 Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. Catecholamines 56-69 renin Homo sapiens 0-5 32609011-0 2020 Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. Catecholamines 56-69 angiotensinogen Homo sapiens 37-51 32609011-1 2020 RATIONALE: Exogenous angiotensin II increases mean arterial pressure in patients with catecholamine-resistant vasodilatory shock (CRVS). Catecholamines 86-99 angiotensinogen Homo sapiens 21-35 32916539-4 2020 Numerous studies have suggested the efficacy of renalase in treating CVD by metabolizing catecholamines in the circulatory system. Catecholamines 89-103 renalase, FAD dependent amine oxidase Homo sapiens 48-56 33173586-8 2020 However, the high PAI-1 group had significantly lower values for intensive care unit-free days (P = 0.01), continuous renal replacement therapy-free days (P = 0.02), and catecholamine-free days (P = 0.02). Catecholamines 170-183 serpin family E member 1 Homo sapiens 18-23 33108341-2 2021 In the present study we focus on three genetic variants important for modulating experimental pain related to serotonin (SLC6A4 5-HTTLPR/rs25531 A>G), catecholamine (COMT rs4680 Val158Met) and opioid (OPRM1 rs1799971 A118G) signaling. Catecholamines 151-164 catechol-O-methyltransferase Homo sapiens 166-170 32338092-1 2020 Renalase is a novel enzyme that can regulate blood pressure by degrading circulating catecholamines. Catecholamines 85-99 renalase, FAD dependent amine oxidase Homo sapiens 0-8 32574581-2 2020 The best-documented gene implicated in aggression is MAOA (Monoamine oxidase A), which encodes the key enzyme for the degradation of serotonin and catecholamines. Catecholamines 147-161 monoamine oxidase A Homo sapiens 53-57 32574581-2 2020 The best-documented gene implicated in aggression is MAOA (Monoamine oxidase A), which encodes the key enzyme for the degradation of serotonin and catecholamines. Catecholamines 147-161 monoamine oxidase A Homo sapiens 59-78 32372682-4 2020 Another abnormality, decreased activity of aldehyde dehydrogenase, may have pathogenetic significance and contribute indirectly to the loss of catecholamine stores via interactions between the autotoxic catecholaldehyde 3,4-dihydroxyphenylacetaldehyde and the protein alpha-synuclein, which is a major component of Lewy bodies. Catecholamines 143-156 synuclein alpha Homo sapiens 268-283 32602936-8 2020 We demonstrate that the beta2 -adrenergic receptor and the classic catecholamine transporters (DAT and NET) play a minor role in transient regulation in the MLN suggesting that regulation at the neural-immune synapse is quite complicated and further mechanistic studies are needed. Catecholamines 67-80 ELK3, member of ETS oncogene family Mus musculus 103-106 32976278-2 2022 COMT modulates catecholamine metabolism, and polymorphisms within the rs4680 allele result in variable enzyme activity. Catecholamines 15-28 catechol-O-methyltransferase Homo sapiens 0-4 33046653-7 2020 Together, membrane voltage per se increases the quantal size of dense-core vesicle release of catecholamine via Vm P2Y12(D76/D127) Gibetagamma QS myocyte contractility, offering a universal Vm-GPCR signaling pathway for its functions in the nervous system and other systems containing GPCRs. Catecholamines 94-107 purinergic receptor P2Y12 Homo sapiens 117-122 32750363-9 2020 In addition, these effects of PIO were associated with up-regulating COMT expression with a subsequent reduction in plasma catecholamines levels. Catecholamines 123-137 catechol-O-methyltransferase Rattus norvegicus 69-73 32931196-8 2020 Angiotensin II caused a significant increase in mean arterial pressure and a rapid reduction in catecholamine vasopressor doses from 0.75 to 0.31 mcg/kg/min norepinephrine equivalents. Catecholamines 96-109 angiotensinogen Homo sapiens 0-14 32931196-11 2020 CONCLUSION: Exogenous angiotensin II reduced catecholamine vasopressor doses and had an apparent effect in reducing endogenous renin production in this case. Catecholamines 45-58 angiotensinogen Homo sapiens 22-36 32844470-6 2020 In addition, the plasma thyroid-stimulating hormone and thyroid hormone concentrations, as well as HFD-induced catecholamine secretion, were higher in LTA4 H-KO mice. Catecholamines 111-124 leukotriene A4 hydrolase Mus musculus 151-157 32844470-8 2020 These results indicate that LTA4 H mediates the diet-induced obesity by reducing catecholamine and thyroid hormone secretion. Catecholamines 81-94 leukotriene A4 hydrolase Mus musculus 28-34 32771675-5 2020 For instance, the catecholamine biosynthetic pathway, which leads to L-DOPA production, could occur by hydroxylation of tyrosine to L-DOPA either by polyphenol oxidase (PPO) or tyrosine hydroxylase (TH). Catecholamines 18-31 protoporphyrinogen oxidase Bos taurus 169-172 32947820-7 2020 The NE and E+NE groups showed severe pulmonary edema while all catecholamine-administering groups demonstrated reduced expression of receptor for advanced glycation end products and increased connexin43 levels in lung tissue. Catecholamines 63-76 gap junction protein, alpha 1 Rattus norvegicus 192-202 32585157-13 2020 In vitro studies showed that propranolol does not affect beta-MHC expression on its own but antagonizes catecholamine effects on beta-MHC expression. Catecholamines 104-117 myosin, heavy polypeptide 7, cardiac muscle, beta Mus musculus 129-137 32931038-7 2021 The physiological relevance of this crosstalk was also demonstrated in neuroendocrine chromaffin cells, wherein Panx1 channels and P2X7 receptors contribute to the exocytotic release of catecholamines triggered by alpha7 nAChRs, as measured by amperometry. Catecholamines 186-200 pannexin 1 Homo sapiens 112-117 32562431-7 2020 When intercrossed pregnant dams were fed with synthetic adrenaline analogs, the lethality of the Gata2 NC-CKO embryos was partially rescued, indicating that placental transfer of the adrenaline analogs complements the lethal catecholamine-deficiency in the Gata2 NC-CKO embryos. Catecholamines 225-238 GATA binding protein 2 Mus musculus 97-102 32658551-3 2020 Dopamine beta hydroxylase (DBH), a key player in the catecholamine biosynthetic pathway, may provide a therapeutic opportunity and should be extensively explored as a target for potent anti-hypertensives. Catecholamines 53-66 dopamine beta-hydroxylase Homo sapiens 0-25 32658551-3 2020 Dopamine beta hydroxylase (DBH), a key player in the catecholamine biosynthetic pathway, may provide a therapeutic opportunity and should be extensively explored as a target for potent anti-hypertensives. Catecholamines 53-66 dopamine beta-hydroxylase Homo sapiens 27-30 32562431-6 2020 The vast majority of Gata2 NC-CKO embryos died by embryonic day 14.5 (e14.5) and exhibited a decrease of catecholamine-producing adrenal chromaffin cells, implying that a potential catecholamine defect might lead to the observed embryonic lethality. Catecholamines 105-118 GATA binding protein 2 Mus musculus 21-26 32562431-7 2020 When intercrossed pregnant dams were fed with synthetic adrenaline analogs, the lethality of the Gata2 NC-CKO embryos was partially rescued, indicating that placental transfer of the adrenaline analogs complements the lethal catecholamine-deficiency in the Gata2 NC-CKO embryos. Catecholamines 225-238 GATA binding protein 2 Mus musculus 257-262 32562431-6 2020 The vast majority of Gata2 NC-CKO embryos died by embryonic day 14.5 (e14.5) and exhibited a decrease of catecholamine-producing adrenal chromaffin cells, implying that a potential catecholamine defect might lead to the observed embryonic lethality. Catecholamines 181-194 GATA binding protein 2 Mus musculus 21-26 32668278-5 2020 Tyrosine hydroxylase (TH) was expressed in >90% of adrenal, abdominal, and thoracic PGLs but only in 37% of head and neck PGLs reflecting their variable catecholamine synthesis. Catecholamines 153-166 tyrosine hydroxylase Homo sapiens 0-20 32668278-5 2020 Tyrosine hydroxylase (TH) was expressed in >90% of adrenal, abdominal, and thoracic PGLs but only in 37% of head and neck PGLs reflecting their variable catecholamine synthesis. Catecholamines 153-166 tyrosine hydroxylase Homo sapiens 22-24 32685251-1 2020 We report two cases of neonates with complex congenital heart disease and volume, catecholamine, and corticosteroid refractory shock treated with arginine-vasopressin. Catecholamines 82-95 arginine vasopressin Homo sapiens 155-166 32953411-1 2020 Catechol-O-methyl transferase (COMT) enzyme has a role in the inactivation of catecholamine neurotransmitters. Catecholamines 78-91 catechol-O-methyltransferase Homo sapiens 0-29 32569990-11 2020 Interestingly, in the same mice, indole induced a dramatic increase of the expression of the adrenomedullary Pnmt gene, which is involved in catecholamine biosynthesis. Catecholamines 141-154 phenylethanolamine-N-methyltransferase Mus musculus 109-113 32654554-4 2020 Carbidopa is a selective DOPA-decarboxylase inhibitor that suppresses catecholamines production outside the brain. Catecholamines 70-84 dopa decarboxylase Homo sapiens 25-43 32593787-1 2020 Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearance of dopamine (DA) in prefrontal cortex. Catecholamines 66-80 catechol-O-methyltransferase Mus musculus 0-28 32593787-1 2020 Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearance of dopamine (DA) in prefrontal cortex. Catecholamines 66-80 catechol-O-methyltransferase Mus musculus 30-34 32953411-1 2020 Catechol-O-methyl transferase (COMT) enzyme has a role in the inactivation of catecholamine neurotransmitters. Catecholamines 78-91 catechol-O-methyltransferase Homo sapiens 31-35 32702980-1 2020 Phenylethanolamine N-methyltransferase (PNMT) is a critical enzyme in catecholamine synthesis. Catecholamines 70-83 phenylethanolamine N-methyltransferase Homo sapiens 0-38 32702980-1 2020 Phenylethanolamine N-methyltransferase (PNMT) is a critical enzyme in catecholamine synthesis. Catecholamines 70-83 phenylethanolamine N-methyltransferase Homo sapiens 40-44 32868151-3 2021 Angiotensin II (ANG-2) is of increasing interest as an adjunct to traditional therapy, both for improvement in blood pressure and for sparing the use of high-dose catecholamine vasopressors. Catecholamines 163-176 angiotensinogen Homo sapiens 0-14 32868151-3 2021 Angiotensin II (ANG-2) is of increasing interest as an adjunct to traditional therapy, both for improvement in blood pressure and for sparing the use of high-dose catecholamine vasopressors. Catecholamines 163-176 angiopoietin 2 Homo sapiens 16-21 32522342-0 2020 Metastasis-associated protein 1 (MTA1) regulates the catecholamine production homeostasis via transcriptional repression of aromatic l-amino acid decarboxylase (Aadc) in the interstitial cells of Cajal of mouse prostate. Catecholamines 53-66 metastasis associated 1 Mus musculus 33-37 32522342-0 2020 Metastasis-associated protein 1 (MTA1) regulates the catecholamine production homeostasis via transcriptional repression of aromatic l-amino acid decarboxylase (Aadc) in the interstitial cells of Cajal of mouse prostate. Catecholamines 53-66 dopa decarboxylase Mus musculus 161-165 32522342-4 2020 Consistently, the ICCs from MTA1-/- mice produced higher levels of catecholamines upon induction of in vitro chronic prostatitis. Catecholamines 67-81 metastasis associated 1 Mus musculus 28-32 32522342-5 2020 Mechanistically, MTA1 could directly suppress the transcription of Aadc, a rate-limiting enzyme during catecholamine synthesis, in a HDAC2-depdendent manner. Catecholamines 103-116 metastasis associated 1 Mus musculus 17-21 32522342-5 2020 Mechanistically, MTA1 could directly suppress the transcription of Aadc, a rate-limiting enzyme during catecholamine synthesis, in a HDAC2-depdendent manner. Catecholamines 103-116 dopa decarboxylase Mus musculus 67-71 32522342-6 2020 Importantly, treatment with AADC inhibitor NSD-1015 significantly ameliorated EAP-elicited pain response and catecholamine overactivity in MTA1-/- mice. Catecholamines 109-122 dopa decarboxylase Mus musculus 28-32 32522342-7 2020 Taken together, our findings reveal an inherent regulatory role of the MTA1/AADC pathway in the maintenance of catecholamine production homeostasis in prostate ICCs, and also point to a potential use of HDAC inhibitors and/or AADC inhibitors to treat CP/CPPS. Catecholamines 111-124 metastasis associated 1 Mus musculus 71-75 32522342-7 2020 Taken together, our findings reveal an inherent regulatory role of the MTA1/AADC pathway in the maintenance of catecholamine production homeostasis in prostate ICCs, and also point to a potential use of HDAC inhibitors and/or AADC inhibitors to treat CP/CPPS. Catecholamines 111-124 dopa decarboxylase Mus musculus 76-80 32335195-10 2020 The administration of Ang-(1-7) reverted the low resistance in response to catecholamines of rings of thoracic aorta isolated from endotoxemic rats, treated or not, with this peptide by a mechanism dependent on the regulation of NO released from perivascular adipose tissue. Catecholamines 75-89 angiogenin Rattus norvegicus 22-30 32758260-1 2020 BACKGROUND: The protein chromogranin A (CgA) is stored and co-released with catecholamines from the stimulated adrenal glands. Catecholamines 76-90 chromogranin-A Canis lupus familiaris 24-38 32758260-1 2020 BACKGROUND: The protein chromogranin A (CgA) is stored and co-released with catecholamines from the stimulated adrenal glands. Catecholamines 76-90 chromogranin-A Canis lupus familiaris 40-43 32417536-8 2020 Serum catecholamine levels were lower in the Prrx1Cre;Sncafl/fl both on a low fat diet (LFD) and HFD versus fl/fl controls. Catecholamines 6-19 paired related homeobox 1 Mus musculus 45-50 32663189-9 2020 Unlike the gain-of-function mechanism observed in RYR2-mediated CPVT, the homozygous multi-exon duplication precipitates a dramatic reduction in RYR2 transcription and RyR2 protein translation, a loss-of-function in calcium handling, and a calcium-induced calcium release apparatus that is insensitive to catecholamines and caffeine. Catecholamines 305-319 ryanodine receptor 2 Homo sapiens 145-149 32750731-3 2020 Catecholamines modulates myocardial function through Beta adrenoceptors and their blockers (beta-AR) reduces cardiovascular morbidity and mortality by decelerating the LVH progression. Catecholamines 0-14 adrenergic receptor, beta 1 Mus musculus 92-99 31991026-3 2020 Recent evidence shows that the selective vulnerability could arise due to the large presence of cytosolic catecholamines and Ca2+ ions in the substantia nigra pars compacta and locus coeruleus specifically, that can be aberrantly affected by alpha-synuclein accumulation. Catecholamines 106-120 synuclein alpha Homo sapiens 242-257 32671919-14 2020 These results suggest that the anterior pituitary synthesises DA from l-dopa by AADC and this catecholamine can be released from this gland contributing to the control of PRL secretion. Catecholamines 94-107 prolactin Mus musculus 171-174 32678054-2 2020 Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase vasopressor responsiveness and reduce catecholamine requirements in septic shock. Catecholamines 129-142 glycoprotein hormone subunit alpha 2 Homo sapiens 39-45 32760338-5 2020 Additionally, there is an inherent autotoxicity of catecholamines in the neuronal cells in which they are produced, forming toxic catecholaldehyde intermediates that make alpha-synuclein prone to aggregation, initiating a cascade of events that ultimately leads to neuronal death. Catecholamines 51-65 synuclein alpha Homo sapiens 171-186 32741114-12 2020 This might be related to catecholamines because signaling through the protein synthesis pathway was increased following denervation in renalase KO mice compared with that in WT mice, despite showing no change in signaling through protein degradation pathways. Catecholamines 25-39 renalase, FAD-dependent amine oxidase Mus musculus 135-143 32909718-0 2020 Catecholamine-Sparing Effect of Angiotensin II in an Anephric Patient With Mixed Shock After Cardiac Revascularization Surgery: A Case Report. Catecholamines 0-13 angiotensinogen Homo sapiens 32-46 32347156-10 2020 Pendrin may also modulate blood pressure in part through its action in the adrenal medulla, where it modulates the release of catecholamines, or through an indirect effect on vascular contractile force. Catecholamines 126-140 solute carrier family 26 member 4 Homo sapiens 0-7 32694788-0 2020 Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Catecholamines 0-14 signal transducer and activator of transcription 3 Mus musculus 100-105 32694788-4 2020 Here, we report that catecholamines redirect FAs for oxidation through the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Catecholamines 21-35 signal transducer and activator of transcription 3 Mus musculus 94-144 32694788-4 2020 Here, we report that catecholamines redirect FAs for oxidation through the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Catecholamines 21-35 signal transducer and activator of transcription 3 Mus musculus 146-151 32249515-0 2020 Unveiling the Role of DJ-1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro-Tip Electrodes. Catecholamines 71-84 Parkinson disease (autosomal recessive, early onset) 7 Mus musculus 22-26 32532855-0 2020 Correction: EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells. Catecholamines 27-40 EPH receptor B6 Homo sapiens 12-17 32503233-8 2020 The physiological mechanisms underlying this result may be related to catestatin activity, a bioactive product of the proteolytic cleavage of CgA, that acts as an inhibitor of catecholamine release. Catecholamines 176-189 chromogranin-A Equus asinus 142-145 32488451-10 2021 Mutations in CASQ2 and CASQ1 have been identified, respectively, in patients with catecholamine-induced polymorphic ventricular tachycardia and in patients with some forms of myopathy. Catecholamines 82-95 calsequestrin 2 Homo sapiens 13-18 32488451-10 2021 Mutations in CASQ2 and CASQ1 have been identified, respectively, in patients with catecholamine-induced polymorphic ventricular tachycardia and in patients with some forms of myopathy. Catecholamines 82-95 calsequestrin 1 Homo sapiens 23-28 31819159-3 2020 Here, we evaluated whether the mitochondrial enzyme monoamine oxidase-A (MAO-A), which generates H2O2 as a by-product of catecholamine metabolism, is a source of deleterious 4-HNE in HF. Catecholamines 121-134 monoamine oxidase A Mus musculus 52-71 31819159-3 2020 Here, we evaluated whether the mitochondrial enzyme monoamine oxidase-A (MAO-A), which generates H2O2 as a by-product of catecholamine metabolism, is a source of deleterious 4-HNE in HF. Catecholamines 121-134 monoamine oxidase A Mus musculus 73-78 32034992-1 2020 INTRODUCTION: Beta-2-adrenergic receptor (ADRB2) is present in the cells of the respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a target for endogenous catecholamines and drugs used to treat obstructive lung diseases. Catecholamines 196-210 adrenoceptor beta 2 Homo sapiens 14-40 32034992-1 2020 INTRODUCTION: Beta-2-adrenergic receptor (ADRB2) is present in the cells of the respiratory tract, including bronchial smooth muscle cells and bronchial epithelium, and is a target for endogenous catecholamines and drugs used to treat obstructive lung diseases. Catecholamines 196-210 adrenoceptor beta 2 Homo sapiens 42-47 32317389-2 2020 Catecholamines are known to alter GH secretion and neurons expressing TH are located in several brain areas containing GH-responsive cells. Catecholamines 0-14 growth hormone Mus musculus 34-36 32053739-1 2020 Renalase is predominantly expressed in the kidney, where it plays a role in catecholamine metabolism and blood pressure regulation. Catecholamines 76-89 renalase, FAD-dependent amine oxidase Rattus norvegicus 0-8 32119934-0 2020 Thiol-mediated and catecholamine-enhanced multimerization of a cerebrovascular disease enriched fragment of NOTCH3. Catecholamines 19-32 notch receptor 3 Homo sapiens 108-114 32321761-0 2020 The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells. Catecholamines 45-58 Eph receptor B6 Mus musculus 29-34 32321761-1 2020 The erythropoietin-producing human hepatocellular receptor EPH receptor B6 (EPHB6) is a receptor tyrosine kinase that has been shown previously to control catecholamine synthesis in the adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent fashion. Catecholamines 155-168 erythropoietin Homo sapiens 4-18 32321761-1 2020 The erythropoietin-producing human hepatocellular receptor EPH receptor B6 (EPHB6) is a receptor tyrosine kinase that has been shown previously to control catecholamine synthesis in the adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent fashion. Catecholamines 155-168 EPH receptor B6 Homo sapiens 59-74 32321761-1 2020 The erythropoietin-producing human hepatocellular receptor EPH receptor B6 (EPHB6) is a receptor tyrosine kinase that has been shown previously to control catecholamine synthesis in the adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent fashion. Catecholamines 155-168 EPH receptor B6 Homo sapiens 76-81 32321761-6 2020 Of note, reverse signaling from EPHB6 to ephrin B1 (EFNB1) and a seven-amino-acid-long segment in the EFNB1 intracellular tail were essential for the regulation of catecholamine secretion. Catecholamines 164-177 Eph receptor B6 Mus musculus 32-37 32321761-6 2020 Of note, reverse signaling from EPHB6 to ephrin B1 (EFNB1) and a seven-amino-acid-long segment in the EFNB1 intracellular tail were essential for the regulation of catecholamine secretion. Catecholamines 164-177 ephrin B1 Mus musculus 41-50 32321761-6 2020 Of note, reverse signaling from EPHB6 to ephrin B1 (EFNB1) and a seven-amino-acid-long segment in the EFNB1 intracellular tail were essential for the regulation of catecholamine secretion. Catecholamines 164-177 ephrin B1 Mus musculus 52-57 32321761-6 2020 Of note, reverse signaling from EPHB6 to ephrin B1 (EFNB1) and a seven-amino-acid-long segment in the EFNB1 intracellular tail were essential for the regulation of catecholamine secretion. Catecholamines 164-177 ephrin B1 Mus musculus 102-107 32321761-8 2020 We discuss the implications of EPHB6"s effect on catecholamine exocytosis and secretion for blood pressure regulation. Catecholamines 49-62 Eph receptor B6 Mus musculus 31-36 32536873-11 2020 Using dissected rat adrenal medulla as a model, we found that treatment with a mGluR1 agonist activated extracellular signal-regulated kinase (ERK) 1/2 and increased the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Catecholamines 239-252 glutamate metabotropic receptor 1 Rattus norvegicus 79-85 32317389-2 2020 Catecholamines are known to alter GH secretion and neurons expressing TH are located in several brain areas containing GH-responsive cells. Catecholamines 0-14 growth hormone Mus musculus 119-121 32409296-7 2020 Consistent with epinephrine in CSF being bound by RF and required for urp expression, treating sspo mutants with this catecholamine rescued expression of the urp genes and axial defects. Catecholamines 118-131 SCO-spondin, pseudogene Homo sapiens 95-99 32536873-14 2020 Furthermore, mGluR1 may be involved in catecholamine biosynthesis by regulating TH, and mGluR5 may affect cortical and medullar hormone levels by regulating microvascular function. Catecholamines 39-52 glutamate metabotropic receptor 1 Homo sapiens 13-19 32447339-7 2020 In the AB-VNS group, with the progression of reduced cardiac sympathetic activities and augmented cardiac parasympathetic activities, the catecholamine concentration in heart tissue declined in the peripheral infarction area and right ventricle (RV); tyrosine hydroxylase (TH)-positive neurons decreased in the inferior cardiac sympathetic nerve, and choline acetyltransferase (ChAT)-positive neurons increased in the cervical vagus nerve. Catecholamines 138-151 choline O-acetyltransferase Canis lupus familiaris 351-376 32447339-7 2020 In the AB-VNS group, with the progression of reduced cardiac sympathetic activities and augmented cardiac parasympathetic activities, the catecholamine concentration in heart tissue declined in the peripheral infarction area and right ventricle (RV); tyrosine hydroxylase (TH)-positive neurons decreased in the inferior cardiac sympathetic nerve, and choline acetyltransferase (ChAT)-positive neurons increased in the cervical vagus nerve. Catecholamines 138-151 choline O-acetyltransferase Canis lupus familiaris 378-382 32409296-7 2020 Consistent with epinephrine in CSF being bound by RF and required for urp expression, treating sspo mutants with this catecholamine rescued expression of the urp genes and axial defects. Catecholamines 118-131 urotensin 2B Homo sapiens 158-161 32310225-5 2020 Energy expenditure and brown adipose tissue metabolism in Asxl2DeltaLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. Catecholamines 180-194 ASXL transcriptional regulator 2 Mus musculus 58-72 32251161-0 2020 A Patient With Tricyclic Antidepressant Overdose With Catecholamine-Resistant Hypotension Rescued With Angiotensin II: A Case Report. Catecholamines 54-67 angiotensinogen Homo sapiens 103-117 32251161-2 2020 The purpose of this case is to describe how the use of angiotensin II can improve hemodynamic parameters and result in a dose reduction of other catecholamine vasopressors in vasodilatory shock. Catecholamines 145-158 angiotensinogen Homo sapiens 55-69 32246073-8 2020 Moreover, expression levels of anxiety-associated genes (orx and cck) and catecholamine production (gr, mr, th1 and th2) were significantly higher in NPY-KO zebrafish than in wild-type fish. Catecholamines 74-87 neuropeptide Y Danio rerio 150-153 32001221-2 2020 In guinea-pig AM cells, PACAP induces little catecholamine secretion, but enhances secretion evoked by stimulants, whereas in other animals, such as mouse, PACAP itself induces depolarization and/or catecholamine secretion. Catecholamines 45-58 adenylate cyclase activating polypeptide 1 Mus musculus 24-29 32001221-2 2020 In guinea-pig AM cells, PACAP induces little catecholamine secretion, but enhances secretion evoked by stimulants, whereas in other animals, such as mouse, PACAP itself induces depolarization and/or catecholamine secretion. Catecholamines 199-212 adenylate cyclase activating polypeptide 1 Mus musculus 24-29 32001221-2 2020 In guinea-pig AM cells, PACAP induces little catecholamine secretion, but enhances secretion evoked by stimulants, whereas in other animals, such as mouse, PACAP itself induces depolarization and/or catecholamine secretion. Catecholamines 199-212 adenylate cyclase activating polypeptide 1 Mus musculus 156-161 32332538-12 2020 CONCLUSIONS: Supplementation with extracellular vesicles derived from adipose-derived stem cells increases fat graft survival and browning by which extracellular vesicles-polarized M2 macrophages secrete catecholamines to promote beige adipose regeneration. Catecholamines 204-218 WD and tetratricopeptide repeats 1 Mus musculus 70-77 32332538-12 2020 CONCLUSIONS: Supplementation with extracellular vesicles derived from adipose-derived stem cells increases fat graft survival and browning by which extracellular vesicles-polarized M2 macrophages secrete catecholamines to promote beige adipose regeneration. Catecholamines 204-218 WD and tetratricopeptide repeats 1 Mus musculus 236-243 32246073-9 2020 We demonstrated that NPY-KO zebrafish have an anxiety phenotype and a stress-vulnerability like NPY-KO mice, whereby orx and/or catecholamine signalling may be involved in the mechanism actions. Catecholamines 128-141 neuropeptide Y Danio rerio 21-24 32035089-1 2020 BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step for the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline. Catecholamines 99-113 tyrosine hydroxylase Mus musculus 12-32 31955909-0 2020 Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body. Catecholamines 33-46 solute carrier family 18 member A1 Rattus norvegicus 76-116 31955909-2 2020 The aim of the present study was to examine the expression of catecholamine-synthesizing enzymes in VMAT1- and VMAT2-immunoreactive glomus cells in the rat CB using multiple immunolabeling. Catecholamines 62-75 solute carrier family 18 member A1 Rattus norvegicus 100-105 31955909-2 2020 The aim of the present study was to examine the expression of catecholamine-synthesizing enzymes in VMAT1- and VMAT2-immunoreactive glomus cells in the rat CB using multiple immunolabeling. Catecholamines 62-75 solute carrier family 18 member A2 Rattus norvegicus 111-116 31955909-6 2020 Immunoreactivities for VMAT1 and tyrosine hydroxylase, the rate-limiting enzyme for catecholamine biosynthesis, were co-localized in the same glomus cells and a positive correlation was confirmed between the two immunoreactivities (Spearman"s coefficient = 0.82; p < 0.05). Catecholamines 84-97 solute carrier family 18 member A1 Rattus norvegicus 23-28 31955909-6 2020 Immunoreactivities for VMAT1 and tyrosine hydroxylase, the rate-limiting enzyme for catecholamine biosynthesis, were co-localized in the same glomus cells and a positive correlation was confirmed between the two immunoreactivities (Spearman"s coefficient = 0.82; p < 0.05). Catecholamines 84-97 tyrosine hydroxylase Rattus norvegicus 33-53 32535571-8 2020 Increased concentrations of catecholamines are associated with increased blood levels of proinflammatory cytokines such as IL-6 and TNF-b.the level of CRP may reflect the inflammatory process in the intima of blood vessels. Catecholamines 28-42 interleukin 6 Homo sapiens 123-127 32535571-8 2020 Increased concentrations of catecholamines are associated with increased blood levels of proinflammatory cytokines such as IL-6 and TNF-b.the level of CRP may reflect the inflammatory process in the intima of blood vessels. Catecholamines 28-42 lymphotoxin alpha Homo sapiens 132-137 32535571-8 2020 Increased concentrations of catecholamines are associated with increased blood levels of proinflammatory cytokines such as IL-6 and TNF-b.the level of CRP may reflect the inflammatory process in the intima of blood vessels. Catecholamines 28-42 C-reactive protein Homo sapiens 151-154 32149734-3 2020 Here we show that refeeding increases plasma leptin concentrations approximately 8-fold in 48-hour-fasted lean rats, and this normalization of plasma leptin concentrations stimulates adrenomedullary catecholamine secretion. Catecholamines 199-212 leptin Rattus norvegicus 150-156 32035089-1 2020 BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step for the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline. Catecholamines 99-113 tyrosine hydroxylase Mus musculus 34-36 32983295-2 2020 Patients with Neurofibromatosis type 1 (NF1) may develop pheochromocytomas, and the consequent chronic elevation of plasma catecholamine levels could further complicate various cardiovascular and pulmonary manifestations they may have. Catecholamines 123-136 neurofibromin 1 Homo sapiens 14-38 32983295-2 2020 Patients with Neurofibromatosis type 1 (NF1) may develop pheochromocytomas, and the consequent chronic elevation of plasma catecholamine levels could further complicate various cardiovascular and pulmonary manifestations they may have. Catecholamines 123-136 neurofibromin 1 Homo sapiens 40-43 31407140-8 2020 When there is a decrease in catecholamine responsiveness, it causes aging in old people because the reduction of betaAR sensitivity and density in the myocardium enhances downregulation of betaARs to AC in the human heart. Catecholamines 28-41 adrenoceptor beta 1 Homo sapiens 113-119 31797234-7 2020 Compared with catecholamine therapy alone, the addition of vasopressin or its analogues was associated with a reduced risk of mortality (relative risk [RR], 0.91; 95% confidence interval [CI], 0.85 to 0.99; low certainty), reduced risk of atrial fibrillation (RR, 0.77; 95% CI, 0.67 to 0.88; high certainty), and increased risk of digital ischemia (RR, 2.56; 95% CI, 1.24 to 5.25; moderate certainty). Catecholamines 14-27 arginine vasopressin Homo sapiens 59-70 31522246-6 2020 Also, the association between the cTnI and duration of the catecholamine use, ICU stay, aortic cross clamp time, and other clinical parameters were assessed. Catecholamines 59-72 troponin I3, cardiac type Homo sapiens 34-38 31522246-7 2020 The cTnI level on postoperative day 1 was positively correlated with the duration of the catecholamine use (p < 0.001) and ICU stay (p < 0.001). Catecholamines 89-102 troponin I3, cardiac type Homo sapiens 4-8 31522246-9 2020 In the multivariable regression analysis, the cTnI was a significant independent predictor of the catecholamine use (p = 0.002) and ICU stay (p = 0.003). Catecholamines 98-111 troponin I3, cardiac type Homo sapiens 46-50 31522246-10 2020 The cTnI level on postoperative day 1 was a predictor of the duration of the catecholamine use and ICU stay. Catecholamines 77-90 troponin I3, cardiac type Homo sapiens 4-8 31714338-1 2020 BACKGROUND: Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. Catecholamines 111-124 chromogranin A Mus musculus 28-32 31714338-1 2020 BACKGROUND: Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. Catecholamines 111-124 chromogranin A Mus musculus 12-26 31955616-3 2020 The insect dopamine/ecdysteroid receptor (DopEcR) is a dual G-protein coupled receptor for the catecholamine dopamine and the steroid hormone ecdysone. Catecholamines 95-108 Ecdysone receptor Drosophila melanogaster 20-40 31955616-3 2020 The insect dopamine/ecdysteroid receptor (DopEcR) is a dual G-protein coupled receptor for the catecholamine dopamine and the steroid hormone ecdysone. Catecholamines 95-108 Dopamine/Ecdysteroid receptor Drosophila melanogaster 42-48 32162598-8 2020 Together with our previous findings in catechol-o-methyltransferase, polymorphisms in catecholamine metabolizing enzymes appear to primarily influence acute pain in SCD. Catecholamines 86-99 catechol-O-methyltransferase Homo sapiens 39-67 32296760-6 2020 In particular, investigating the activation of the catecholamine beta2-adrenergic receptor by a pathogen revealed that traction forces directly exerted on the N-terminus of the receptor via N-glycan chains activate specific signaling pathways. Catecholamines 51-64 adrenoceptor beta 2 Homo sapiens 65-90 32076930-2 2020 The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium, engendering inflammatory activation via biased post-receptor signalling at myocardial beta2-adrenoceptor level. Catecholamines 63-76 adrenoceptor beta 2 Homo sapiens 201-219 32028998-0 2020 Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock. Catecholamines 67-80 angiotensinogen Homo sapiens 18-32 32028998-2 2020 The objective of these protocol prespecified and subsequent post hoc analyses was to assess the epidemiology and outcome associations of plasma ANG I and ANG II levels and their ratio in patients with catecholamine-resistant vasodilatory shock (CRVS) enrolled in the Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) study. Catecholamines 201-214 angiotensinogen Homo sapiens 144-149 31816411-9 2020 Phosphorylation of perilipin-1 and HSL and translocation of HSL to lipid droplets were attenuated in response to catecholamines rather than post-adrenoreceptoral lipolytic stimulators. Catecholamines 113-127 perilipin 1 Rattus norvegicus 19-30 31816411-9 2020 Phosphorylation of perilipin-1 and HSL and translocation of HSL to lipid droplets were attenuated in response to catecholamines rather than post-adrenoreceptoral lipolytic stimulators. Catecholamines 113-127 lipase E, hormone sensitive type Rattus norvegicus 35-38 31816411-9 2020 Phosphorylation of perilipin-1 and HSL and translocation of HSL to lipid droplets were attenuated in response to catecholamines rather than post-adrenoreceptoral lipolytic stimulators. Catecholamines 113-127 lipase E, hormone sensitive type Rattus norvegicus 60-63 31350035-6 2020 RESULTS: LRP1 expression was upregulated in both transverse aortic constriction (TAC)-induced hypertrophic myocardium and catecholamine (phenylephrine (PE) and norepinephrine (NE))- and angiotensin II (AngII)-induced hypertrophic cardiomyocytes. Catecholamines 122-135 LDL receptor related protein 1 Homo sapiens 9-13 31972854-1 2020 Low levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, and stress, which potentiates catecholamine release from sympathetic nerves, are fundamental to chronic functional pain syndromes and comorbid depression, which predominantly affect females. Catecholamines 78-92 catechol-O-methyltransferase Mus musculus 14-42 31972854-1 2020 Low levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, and stress, which potentiates catecholamine release from sympathetic nerves, are fundamental to chronic functional pain syndromes and comorbid depression, which predominantly affect females. Catecholamines 78-92 catechol-O-methyltransferase Mus musculus 44-48 31972854-1 2020 Low levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, and stress, which potentiates catecholamine release from sympathetic nerves, are fundamental to chronic functional pain syndromes and comorbid depression, which predominantly affect females. Catecholamines 78-91 catechol-O-methyltransferase Mus musculus 14-42 31972854-1 2020 Low levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, and stress, which potentiates catecholamine release from sympathetic nerves, are fundamental to chronic functional pain syndromes and comorbid depression, which predominantly affect females. Catecholamines 78-91 catechol-O-methyltransferase Mus musculus 44-48 31972854-9 2020 These results suggest that genetic and environmental factors that enhance catecholamine bioavailability cause abnormalities in BDNF signaling and increase risk of comorbid functional pain and depression, especially among females. Catecholamines 74-87 brain derived neurotrophic factor Mus musculus 127-131 31744341-3 2020 COMT inhibition can block metabolism of catecholamines including DA. Catecholamines 40-54 catechol-O-methyltransferase Homo sapiens 0-4 31820933-6 2020 We also evaluate how the redox cycling of copper bound to tau peptides can mediate oxidation that can potentially target exogenous substrates such as neuronal catecholamines. Catecholamines 159-173 microtubule associated protein tau Homo sapiens 58-61 31910209-13 2020 Systemic 6-OHDA decreased adrenal medulla expression of catecholamine producing enzymes (TH and aromatic L-amino acid decarboxylase) and circulating levels of norepinephrine, which were attenuated by PPARgamma-activation. Catecholamines 56-69 tyrosine hydroxylase Macaca mulatta 89-91 31910209-13 2020 Systemic 6-OHDA decreased adrenal medulla expression of catecholamine producing enzymes (TH and aromatic L-amino acid decarboxylase) and circulating levels of norepinephrine, which were attenuated by PPARgamma-activation. Catecholamines 56-69 peroxisome proliferator activated receptor gamma Macaca mulatta 200-209 31919709-5 2020 The receiver operating characteristic (ROC) plot showed that a combination consisting of IL-17 x SOFA <=22.3 was a reliable predictive factor of the need for catecholamine treatment during HCO-CVVHD, with 82% sensitivity and 90% specificity, with the area under curve (AUC) of 0.843; p < 0.001. Catecholamines 161-174 interleukin 17A Homo sapiens 89-94 32852050-1 2020 Renalase is a recently identified flavoprotein oxidase, secreted mainly by the kidneys, which takes part in the degradation of catecholamines. Catecholamines 127-141 renalase, FAD dependent amine oxidase Homo sapiens 0-8 32549050-2 2020 Chromaffin cell t-PA is sorted into catecholamine storage vesicles and co-released with catecholamines in response to sympathoadrenal activation, suggesting that catecholamine storage vesicles may serve as a reservoir for the rapid release of t-PA. Catecholamines 36-49 plasminogen activator, tissue type Homo sapiens 16-20 32071497-1 2020 Catechol-O-methyletransferase (COMT) enzyme is involved in the inactivation of catecholamine and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 0-29 32071497-1 2020 Catechol-O-methyletransferase (COMT) enzyme is involved in the inactivation of catecholamine and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 31-35 31529487-2 2020 Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal signaling pathways through phosphorylation at serine 19 (Ser19), serine 31 (Ser31) and serine 40 (Ser40) located in the flexible, far N-terminal region of the regulatory domain. Catecholamines 43-56 tyrosine hydroxylase Homo sapiens 0-20 31529487-2 2020 Tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, is regulated by multiple neuronal signaling pathways through phosphorylation at serine 19 (Ser19), serine 31 (Ser31) and serine 40 (Ser40) located in the flexible, far N-terminal region of the regulatory domain. Catecholamines 43-56 tyrosine hydroxylase Homo sapiens 22-24 32655246-2 2020 Nonhealing is possibly because of chronic activation of beta-2 adrenergic receptor (B2-AR) in the keratinocytes by endogenously generated catecholamines, which inhibits keratinocyte migration. Catecholamines 138-152 adrenoceptor beta 2 Homo sapiens 56-82 32655246-2 2020 Nonhealing is possibly because of chronic activation of beta-2 adrenergic receptor (B2-AR) in the keratinocytes by endogenously generated catecholamines, which inhibits keratinocyte migration. Catecholamines 138-152 adrenoceptor beta 2 Homo sapiens 84-89 32549050-2 2020 Chromaffin cell t-PA is sorted into catecholamine storage vesicles and co-released with catecholamines in response to sympathoadrenal activation, suggesting that catecholamine storage vesicles may serve as a reservoir for the rapid release of t-PA. Catecholamines 88-102 plasminogen activator, tissue type Homo sapiens 16-20 32549050-2 2020 Chromaffin cell t-PA is sorted into catecholamine storage vesicles and co-released with catecholamines in response to sympathoadrenal activation, suggesting that catecholamine storage vesicles may serve as a reservoir for the rapid release of t-PA. Catecholamines 88-101 plasminogen activator, tissue type Homo sapiens 16-20 31792650-1 2020 Catestatin (CST) is a catecholamine release-inhibitory peptide secreted from the adrenergic neurons and the adrenal glands. Catecholamines 22-35 chromogranin A Homo sapiens 0-10 32675002-1 2020 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency is a primary neurotransmitter defect of the biosynthesis of catecholamines and serotonin. Catecholamines 126-140 dopa decarboxylase Homo sapiens 12-47 32675002-1 2020 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency is a primary neurotransmitter defect of the biosynthesis of catecholamines and serotonin. Catecholamines 126-140 dopa decarboxylase Homo sapiens 49-53 31792650-1 2020 Catestatin (CST) is a catecholamine release-inhibitory peptide secreted from the adrenergic neurons and the adrenal glands. Catecholamines 22-35 chromogranin A Homo sapiens 12-15 31838976-1 2019 Background Genetic variation in catechol-O-methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease (CVD) and its risk factors. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 32-60 31346893-0 2020 Roles Played by the Na+/Ca2+ Exchanger and Hypothermia in the Prevention of Ischemia-Induced Carrier-Mediated Efflux of Catecholamines into the Extracellular Space: Implications for Stroke Therapy. Catecholamines 120-134 solute carrier family 8 member A1 Homo sapiens 20-38 33654949-12 2019 Since TH is not exclusively expressed on sympathetic fibers, but also in a number of catecholamine-producing cells, a prerequisite for automated determination of fiber densities is to reliably distinguish between cells and fibers. Catecholamines 85-98 tyrosine hydroxylase Homo sapiens 6-8 31838976-1 2019 Background Genetic variation in catechol-O-methyltransferase (COMT), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease (CVD) and its risk factors. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 62-66 31656093-11 2019 In conclusion, the MMP7 A-181G promoter polymorphism increased MMP7 expression under pathophysiological conditions (hypoxic stress and catecholamine excess) via increased interactions with CREB and enhanced the risk for hypertension in its carriers. Catecholamines 135-148 matrix metallopeptidase 7 Homo sapiens 19-23 31155464-13 2019 Previous use of beta-blockers and coronary angiography exploration at admission were associated with better long-term survival, while age, renal replacement therapy and the use of catecholamines appeared to worsen the prognosis, and should lead to intensification of CS management. Catecholamines 180-194 citrate synthase Homo sapiens 267-269 31604529-2 2019 Different to RKIP-mediated beta-AR activation, chronic activation of beta-AR by catecholamines was shown to be detrimental for the heart. Catecholamines 80-94 adrenoceptor beta 2 Homo sapiens 69-76 31567344-1 2019 OBJECTIVES: Vasopressin has achieved common usage for the treatment of catecholamine-requiring and catecholamine-resistant shock. Catecholamines 71-84 arginine vasopressin Homo sapiens 12-23 31567344-1 2019 OBJECTIVES: Vasopressin has achieved common usage for the treatment of catecholamine-requiring and catecholamine-resistant shock. Catecholamines 99-112 arginine vasopressin Homo sapiens 12-23 31656093-11 2019 In conclusion, the MMP7 A-181G promoter polymorphism increased MMP7 expression under pathophysiological conditions (hypoxic stress and catecholamine excess) via increased interactions with CREB and enhanced the risk for hypertension in its carriers. Catecholamines 135-148 matrix metallopeptidase 7 Homo sapiens 63-67 31747589-5 2019 Depletion of ASL in LC neurons leads to reduced amount and activity of tyrosine hydroxylase (TH) and to decreased catecholamines synthesis, due to decreased nitric oxide (NO) signaling. Catecholamines 114-128 argininosuccinate lyase Mus musculus 13-16 31688840-1 2019 INTRODUCTION: Renalase is a novel flavin adenine dinucleotide-dependent amine oxidase with catecholamine-degrading activity. Catecholamines 91-104 renalase, FAD dependent amine oxidase Homo sapiens 14-22 31765327-1 2019 Summary: ACTH-secreting pheochromocytoma is a very rare cause of Cushing"s syndrome, with a high morbidity and mortality risk due to both cortisol and catecholamines excess. Catecholamines 151-165 proopiomelanocortin Homo sapiens 9-13 25905362-12 2000 In the autonomic nervous system, catecholamines have been found to stimulate IL-6 secretion through a beta-adrenergic mechanism showing the immune effects on endocrine system. Catecholamines 33-47 interleukin 6 Homo sapiens 77-81 31293181-1 2019 Background: Renalase is kidney-derived molecule initially considered as catecholamine-inactivating enzyme. Catecholamines 72-85 renalase, FAD dependent amine oxidase Homo sapiens 12-20 31615832-0 2019 Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches. Catecholamines 63-76 N-glycanase 1 Mus musculus 16-21 31615832-13 2019 Worm and fly models of NGLY1 deficiency validate therapeutic rationales for activation of NRF2 and anti-inflammatory pathways based on results in mice and human cell models, and suggest a novel therapeutic rationale for boosting catecholamine levels and/or signaling in the brain. Catecholamines 229-242 N-glycanase 1 Mus musculus 23-28 31419477-2 2019 TH converts tyrosine into L-DOPA, which is the direct precursor of catecholamine biosynthesis. Catecholamines 67-80 tyrosine hydroxylase Homo sapiens 0-2 31697676-6 2019 We then discovered that Epas1 genotype influences heart rate in hypoxia, and the transcriptomic responses to hypoxia (including HIF targets and genes involved in catecholamine signaling) in the heart and adrenal gland. Catecholamines 162-175 endothelial PAS domain protein 1 Mus musculus 24-29 30670847-10 2019 CONCLUSION: These results suggest a common regulatory mechanism of catecholamine metabolism in the placenta and the fetal liver as demonstrated by higher phosphorylated COMT expression in the placenta and fetal liver from animals exposed to diet-induced maternal obesity and lower expression of phosphorylated COMT in animals exposed to maternal androgen excess. Catecholamines 67-80 catechol-O-methyltransferase Mus musculus 169-173 30670847-10 2019 CONCLUSION: These results suggest a common regulatory mechanism of catecholamine metabolism in the placenta and the fetal liver as demonstrated by higher phosphorylated COMT expression in the placenta and fetal liver from animals exposed to diet-induced maternal obesity and lower expression of phosphorylated COMT in animals exposed to maternal androgen excess. Catecholamines 67-80 catechol-O-methyltransferase Mus musculus 310-314 31194241-2 2019 PARTICIPANTS: We report a series of 10 patients carrying pathogenic variants in the SDHD gene from five tertiary referral centers for paraganglioma (PGL) in the Netherlands, who presented with a sympathetic PGL (sPGL), pheochromocytoma (PHEO), or metastases outside the head and neck region in the absence of excessive catecholamine production. Catecholamines 319-332 succinate dehydrogenase complex subunit D Homo sapiens 84-88 31473246-3 2019 Previous studies have identified TNF-related apoptosis inducing ligand (TRAIL) and its receptor, DR5, as being altered in a chronic catecholamine administration model of heart failure, and suggest a role of non-canonical signaling in cardiomyocytes. Catecholamines 132-145 tumor necrosis factor receptor superfamily, member 10b Mus musculus 97-100 31473246-3 2019 Previous studies have identified TNF-related apoptosis inducing ligand (TRAIL) and its receptor, DR5, as being altered in a chronic catecholamine administration model of heart failure, and suggest a role of non-canonical signaling in cardiomyocytes. Catecholamines 132-145 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 33-70 31503068-5 2019 ECH treatments also upregulated expression of tyrosine hydroxylase, the enzyme mediating catecholamine synthesis, in neuroblastoma cell culture. Catecholamines 89-102 tyrosine hydroxylase Mus musculus 46-66 31473246-3 2019 Previous studies have identified TNF-related apoptosis inducing ligand (TRAIL) and its receptor, DR5, as being altered in a chronic catecholamine administration model of heart failure, and suggest a role of non-canonical signaling in cardiomyocytes. Catecholamines 132-145 tumor necrosis factor (ligand) superfamily, member 10 Mus musculus 72-77 31609201-5 2019 Moreover, we have engineered a mutant beta2AR that lacks the catecholamine binding pocket. Catecholamines 61-74 adrenoceptor beta 2 Homo sapiens 38-45 31556016-1 2019 BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Catecholamines 101-115 monoamine oxidase A Homo sapiens 16-36 31556016-1 2019 BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Catecholamines 101-115 monoamine oxidase A Homo sapiens 38-43 31742248-1 2019 Catecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Catecholamines 0-14 abhydrolase domain containing 5 Mus musculus 118-123 31491076-2 2019 Catechol-O-methyltransferase (COMT) is involved in the inactivation of the catecholamine neurotransmitters, and it is particularly important for the regulation of dopamine. Catecholamines 75-88 catechol-O-methyltransferase Rattus norvegicus 0-28 31491076-2 2019 Catechol-O-methyltransferase (COMT) is involved in the inactivation of the catecholamine neurotransmitters, and it is particularly important for the regulation of dopamine. Catecholamines 75-88 catechol-O-methyltransferase Rattus norvegicus 30-34 31737132-3 2019 Renalase, a new protein derived from kidneys was demonstrated to metabolize catecholamines and to have a cardioprotective role. Catecholamines 76-90 renalase, FAD dependent amine oxidase Homo sapiens 0-8 31595360-7 2019 Under optimal conditions, the limits of detection for the catecholamines are in the range from 15 to 47 ng mL-1. Catecholamines 58-72 2'-5' oligoadenylate synthetase 1B Mus musculus 107-111 31176001-8 2019 In vitro, catecholamine treatment triggered the M2 polarization of macrophages, enhanced the expression of VEGF, promoted tumor angiogenesis, and these catecholamine-stimulated effects could be reversed by the adrenergic receptor antagonist propranolol. Catecholamines 10-23 vascular endothelial growth factor A Homo sapiens 107-111 31176001-8 2019 In vitro, catecholamine treatment triggered the M2 polarization of macrophages, enhanced the expression of VEGF, promoted tumor angiogenesis, and these catecholamine-stimulated effects could be reversed by the adrenergic receptor antagonist propranolol. Catecholamines 152-165 vascular endothelial growth factor A Homo sapiens 107-111 31537818-0 2019 Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats. Catecholamines 65-78 glucagon Rattus norvegicus 8-31 31513823-0 2019 The effects of DPP4 inhibitors on the levels of plasma catecholamines and their metabolites in patients with type 2 diabetes. Catecholamines 55-69 dipeptidyl peptidase 4 Homo sapiens 15-19 31279527-0 2019 Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells. Catecholamines 133-146 5'-nucleotidase domain containing 2 Rattus norvegicus 35-41 31686824-2 2019 Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Catecholamines 80-93 interleukin 6 Homo sapiens 64-68 31279527-0 2019 Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases catecholamine synthesis in PC12D cells. Catecholamines 133-146 5'-nucleotidase domain containing 2 Rattus norvegicus 107-113 31279527-7 2019 The down-regulation of NT5DC2 by siRNA increased the synthesis of catecholamines (dopamine, noradrenaline, and adrenaline) in PC12D cells. Catecholamines 66-80 5'-nucleotidase domain containing 2 Rattus norvegicus 23-29 31306490-12 2019 Taken together, our results point to a novel mechanism by which Ang II participates in the regulation of axonal synthesis of NE by modulating the local trafficking and expression of TH and DBH, two key enzymes involved in the catecholamine biosynthetic pathway. Catecholamines 226-239 angiotensinogen Rattus norvegicus 64-70 31306490-12 2019 Taken together, our results point to a novel mechanism by which Ang II participates in the regulation of axonal synthesis of NE by modulating the local trafficking and expression of TH and DBH, two key enzymes involved in the catecholamine biosynthetic pathway. Catecholamines 226-239 tyrosine hydroxylase Rattus norvegicus 182-184 31306490-12 2019 Taken together, our results point to a novel mechanism by which Ang II participates in the regulation of axonal synthesis of NE by modulating the local trafficking and expression of TH and DBH, two key enzymes involved in the catecholamine biosynthetic pathway. Catecholamines 226-239 dopamine beta-hydroxylase Rattus norvegicus 189-192 31413360-5 2019 Like AICAR, an activator of AMPK, catecholamines (norepinephrine and isoproterenol) and SFAs (palmitate and stearate) significantly increased FGF21 production and release by cardiac myocytes via AMPK activation. Catecholamines 34-48 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 5-10 32166277-3 2019 Both patients had a significant increase in mean arterial pressure shortly after initiation of angiotensin II, with a reduction of the dose of catecholamines and vasopressin infusions. Catecholamines 143-157 angiotensinogen Homo sapiens 95-109 31112503-6 2019 The activity of catechol-O-methyltransferase (COMT), a key catecholamine-inactivating enzyme that has been scantly investigated thus far owing to the lack of commercially available kits, will be also determined by a newly developed high performance liquid chromatography method, which is herein described. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 16-44 31112503-6 2019 The activity of catechol-O-methyltransferase (COMT), a key catecholamine-inactivating enzyme that has been scantly investigated thus far owing to the lack of commercially available kits, will be also determined by a newly developed high performance liquid chromatography method, which is herein described. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 46-50 31413360-5 2019 Like AICAR, an activator of AMPK, catecholamines (norepinephrine and isoproterenol) and SFAs (palmitate and stearate) significantly increased FGF21 production and release by cardiac myocytes via AMPK activation. Catecholamines 34-48 fibroblast growth factor 21 Homo sapiens 142-147 31413360-5 2019 Like AICAR, an activator of AMPK, catecholamines (norepinephrine and isoproterenol) and SFAs (palmitate and stearate) significantly increased FGF21 production and release by cardiac myocytes via AMPK activation. Catecholamines 34-48 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 195-199 30964706-9 2019 Taken together, white adipose tissue of lean mice with OM shows increased sensitization to HFD compared with white adipose tissue with no OM, rendering it resistant to catecholamine-induced lipolysis. Catecholamines 168-181 oncomodulin Mus musculus 55-57 31374106-4 2019 We tested the hypothesis that chronic (daily) behavioral vocal exercise of male Pink1-/- rats would alter ultrasonic vocalization acoustics and mesolimbic neurochemistry (catecholamines, GABA, mu-opioid receptor) compared to three different controls: sham-exercised Pink1-/-, unexercised Pink1-/-, and unexercised wildtype (WT) rats. Catecholamines 171-185 PTEN induced kinase 1 Rattus norvegicus 80-85 31025531-2 2019 During the procedure, the patient developed catecholamine refractory hypotension requiring the administration of several vasopressin boluses to maintain adequate perfusion pressure. Catecholamines 44-57 arginine vasopressin Homo sapiens 121-132 30995994-8 2019 Epigenetic analysis and chromatin state models of the implicated 70 kb region of 10q23.31 support active transcription of the gene RNLS in the brain, which encodes a catecholamine metabolising protein. Catecholamines 166-179 renalase, FAD dependent amine oxidase Homo sapiens 131-135 30836837-8 2019 Post-race catecholamine levels explained 60% of the variance in the IL-6 response (r = 0.77, p = 0.040), which was further increased when the resting autonomic function indices were added to the regression model (R2 > 81%, p < 0.012). Catecholamines 10-23 interleukin 6 Homo sapiens 68-72 30714297-1 2019 BACKGROUND: Catestatin is a chromogranin A-derived peptide with a wide spectrum of biological activities, such as inhibiting catecholamine release, decreasing blood pressure, stimulating histamine release, reducing beta-adrenergic stimulation, and regulating oxidative stress. Catecholamines 125-138 chromogranin A Homo sapiens 12-22 31113827-3 2019 Insm1 gene ablation results in impairment of pancreatic beta cells, catecholamine biosynthesis, and basal progenitor development during mammalian neocortex maturation. Catecholamines 68-81 INSM transcriptional repressor 1 Homo sapiens 0-5 31367972-1 2019 Pheochromocytomas and paragangliomas (PCC/PGL) are neuroendocrine tumors of the adrenal medulla and extra-adrenal ganglia which often over-secrete catecholamines leading to cardiovascular morbidity and even mortality. Catecholamines 147-161 crystallin gamma D Homo sapiens 38-41 30874296-1 2019 BACKGROUND AND PURPOSE: Stress-related catecholamines have a role in cancer and beta-adrenoceptors; specifically, beta2 -adrenoceptors have been identified as new targets in treating melanoma. Catecholamines 39-53 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Mus musculus 114-119 31345252-0 2019 Use of low-dose beta1-blocker for sinus tachycardia in patients with catecholamine support following cardiovascular surgery: a retrospective study. Catecholamines 69-82 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 16-21 31299889-9 2019 We established a correlation between hypothalamic levels of Bmal1 and urinary catecholamine concentrations. Catecholamines 78-91 aryl hydrocarbon receptor nuclear translocator-like Rattus norvegicus 60-65 30471093-1 2019 Stress plays a role in tumourigenesis through catecholamines acting at beta-adrenoceptors including beta1 -, beta2 - and beta3 -adrenoceptors, and the use of beta-adrenoceptor antagonists seems to counteract tumour growth and progression. Catecholamines 46-60 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 100-126 31337827-4 2019 We show that visceral adipocyte adiponectin release is triggered by cAMP/catecholamines via signalling pathways involving adrenergic beta-3-receptors (beta3ARs) and Exchange Protein directly Activated by cAMP, isoform 1 (Epac1). Catecholamines 73-87 adiponectin, C1Q and collagen domain containing Mus musculus 32-43 31337827-4 2019 We show that visceral adipocyte adiponectin release is triggered by cAMP/catecholamines via signalling pathways involving adrenergic beta-3-receptors (beta3ARs) and Exchange Protein directly Activated by cAMP, isoform 1 (Epac1). Catecholamines 73-87 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 165-219 31337827-4 2019 We show that visceral adipocyte adiponectin release is triggered by cAMP/catecholamines via signalling pathways involving adrenergic beta-3-receptors (beta3ARs) and Exchange Protein directly Activated by cAMP, isoform 1 (Epac1). Catecholamines 73-87 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 221-226 31189126-7 2019 The Mc2r knockout (Mc2r-/-) mice was the first mouse model developed to have adrenal insufficiency with deficiencies in glucocorticoid, mineralocorticoid and catecholamines. Catecholamines 158-172 melanocortin 2 receptor Mus musculus 4-8 30901278-12 2019 NEW & NOTEWORTHY Male amyloid precursor protein (APP)-deficient mice have higher circulating levels of catecholamines as compared with female APP-deficient mice. Catecholamines 107-121 amyloid beta (A4) precursor protein Mus musculus 26-51 30651588-4 2019 In the adrenal glands of prehypertensive SHR, the expression of catecholamine biosynthetic enzymes Ddc, Dbh and Pnmt was lower than in aged-matched Wistar-Kyoto rats. Catecholamines 64-77 dopa decarboxylase Rattus norvegicus 99-102 30651588-4 2019 In the adrenal glands of prehypertensive SHR, the expression of catecholamine biosynthetic enzymes Ddc, Dbh and Pnmt was lower than in aged-matched Wistar-Kyoto rats. Catecholamines 64-77 dopamine beta-hydroxylase Rattus norvegicus 104-107 30651588-4 2019 In the adrenal glands of prehypertensive SHR, the expression of catecholamine biosynthetic enzymes Ddc, Dbh and Pnmt was lower than in aged-matched Wistar-Kyoto rats. Catecholamines 64-77 phenylethanolamine-N-methyltransferase Rattus norvegicus 112-116 30651588-6 2019 In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). Catecholamines 54-67 dopa decarboxylase Rattus norvegicus 93-96 30651588-6 2019 In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). Catecholamines 54-67 dopamine beta-hydroxylase Rattus norvegicus 98-101 30651588-6 2019 In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001). Catecholamines 54-67 phenylethanolamine-N-methyltransferase Rattus norvegicus 106-110 31353327-1 2019 Beta3-adrenergic receptor (ADRB3) is a mediator of catecholamine-stimulated lipolysis in humans. Catecholamines 51-64 adrenoceptor beta 3 Homo sapiens 0-25 31353327-1 2019 Beta3-adrenergic receptor (ADRB3) is a mediator of catecholamine-stimulated lipolysis in humans. Catecholamines 51-64 adrenoceptor beta 3 Homo sapiens 27-32 31234562-2 2019 Authors designed an immunohistochemical study on the expression of the adrenal beta2-adrenergic receptor (beta2-AR), a receptor with high-affinity for catecholamines, with the aim to show which zones it is expressed in and how its expression differs in relation to the cause of death. Catecholamines 151-165 adrenoceptor beta 2 Homo sapiens 79-104 31234562-2 2019 Authors designed an immunohistochemical study on the expression of the adrenal beta2-adrenergic receptor (beta2-AR), a receptor with high-affinity for catecholamines, with the aim to show which zones it is expressed in and how its expression differs in relation to the cause of death. Catecholamines 151-165 adrenoceptor beta 2 Homo sapiens 106-114 31123076-6 2019 We also found catecholamine stress hormones noradrenaline and adrenaline were present in the dialysates and were apparently involved in enhancing the growth of the bacteria via transferrin iron provision. Catecholamines 14-27 transferrin Homo sapiens 177-188 31239688-2 2019 Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes endogenous catecholamines. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 0-28 31239688-2 2019 Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes endogenous catecholamines. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 30-34 31396845-3 2019 The results confirmed diminishing effect of immunization on nerve fiber-derived noradrenaline supply and showed that antigen presenting and CD4+ cells synthesize catecholamines, while antigen presenting cells and only CD4+CD25+Foxp3+ regulatory T cells (Tregs) express alpha1-adrenoceptor. Catecholamines 162-176 Cd4 molecule Rattus norvegicus 140-143 31396845-9 2019 Collectively, the results indicated that dLN cell-derived catecholamines may influence EAE development by modulating interactions between distinct subtypes of CD4+ T cells and antigen presenting cells through alpha1-adrenoceptor and consequently CD4+ T cell priming. Catecholamines 58-72 Cd4 molecule Rattus norvegicus 159-162 31396845-9 2019 Collectively, the results indicated that dLN cell-derived catecholamines may influence EAE development by modulating interactions between distinct subtypes of CD4+ T cells and antigen presenting cells through alpha1-adrenoceptor and consequently CD4+ T cell priming. Catecholamines 58-72 Cd4 molecule Rattus norvegicus 246-249 30714137-1 2019 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline. Catecholamines 78-92 tyrosine hydroxylase Homo sapiens 0-20 30714137-1 2019 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline. Catecholamines 78-92 tyrosine hydroxylase Homo sapiens 22-24 30963576-4 2019 By detecting catecholamine release from single vesicles in chromaffin cells, we show that a dominant negative SphK1 (SphK1DN ) reduces the number of amperometric spikes and increases the duration of foot, which reflects release through a fusion pore, implying critical roles for S1P in regulating the rate of exocytosis and fusion pore expansion. Catecholamines 13-26 sphingosine kinase 1 Mus musculus 110-115 30963576-4 2019 By detecting catecholamine release from single vesicles in chromaffin cells, we show that a dominant negative SphK1 (SphK1DN ) reduces the number of amperometric spikes and increases the duration of foot, which reflects release through a fusion pore, implying critical roles for S1P in regulating the rate of exocytosis and fusion pore expansion. Catecholamines 13-26 sphingosine kinase 1 Mus musculus 117-124 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 82-95 catechol-O-methyltransferase Homo sapiens 0-28 30238388-8 2019 These results may allow us to better understand the role of the transsulfuration pathway and especially CBS overexpression in the metabolism of biogenic amines and the catecholamine catabolism in persons with trisomy 21. Catecholamines 168-181 cystathionine beta-synthase Homo sapiens 104-107 30088239-2 2019 To the contrary, catestatin, an endogenous pleiotropic peptide cleaved from chromogranin A, is known for its inhibitory effects on catecholamine release and sympathetic activity. Catecholamines 131-144 chromogranin A Homo sapiens 17-27 30088239-2 2019 To the contrary, catestatin, an endogenous pleiotropic peptide cleaved from chromogranin A, is known for its inhibitory effects on catecholamine release and sympathetic activity. Catecholamines 131-144 chromogranin A Homo sapiens 76-90 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 23-36 catechol-O-methyltransferase Homo sapiens 102-130 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 23-36 catechol-O-methyltransferase Homo sapiens 132-136 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 191-205 catechol-O-methyltransferase Homo sapiens 102-130 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Catecholamines 191-205 catechol-O-methyltransferase Homo sapiens 132-136 30790653-1 2019 The COMT gene encodes for catechol-O-methyl-transferase, an enzyme playing a major role in regulation of synaptic catecholamine neurotransmitters. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 4-8 30790653-1 2019 The COMT gene encodes for catechol-O-methyl-transferase, an enzyme playing a major role in regulation of synaptic catecholamine neurotransmitters. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 26-55 30794821-1 2019 Monoamine oxidase A (MAOA) plays important roles in the metabolism of catecholamines and modulates adrenergic, noradrenergic, and dopaminergic signaling. Catecholamines 70-84 monoamine oxidase A Homo sapiens 0-19 30794821-1 2019 Monoamine oxidase A (MAOA) plays important roles in the metabolism of catecholamines and modulates adrenergic, noradrenergic, and dopaminergic signaling. Catecholamines 70-84 monoamine oxidase A Homo sapiens 21-25 30794821-5 2019 In total, 87 males and 35 females were evaluated and investigated for the possible effect of MAOA-uVNTR polymorphisms on cerebrospinal fluid (CSF) catecholamine concentrations. Catecholamines 147-160 monoamine oxidase A Homo sapiens 93-97 31015364-7 2019 EPAS1 gene is active under hypoxic conditions and plays an essential role in the development of the heart and in the management of the catecholamine balance, mutations of which have been identified in neuroendocrine tumors. Catecholamines 135-148 endothelial PAS domain protein 1 Homo sapiens 0-5 30601161-7 2019 In this randomized, double-blind, placebo-controlled trial, patients in the angiotensin II group achieved higher rates of target mean arterial pressure and had lower catecholamine requirements in the first 3 hours of therapy compared with patients in the placebo group. Catecholamines 166-179 angiotensinogen Homo sapiens 76-90 31259292-5 2019 Central catecholamines stimulate the release of IL-1beta from microglia, which is a key factor in the further activation of microglia and recruitment of monocytes into the brain. Catecholamines 8-22 interleukin 1 beta Homo sapiens 48-56 31156340-2 2019 Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Catecholamines 25-38 renalase, FAD dependent amine oxidase Homo sapiens 0-8 31156340-2 2019 Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Catecholamines 25-38 renalase, FAD dependent amine oxidase Homo sapiens 124-132 31071921-4 2019 Moreover; cardiac specific CXCR4 knockout mice show significant hypertrophy and develop cardiac dysfunction in response to chronic catecholamine exposure in an isoproterenol-induced (ISO) heart failure model. Catecholamines 131-144 chemokine (C-X-C motif) receptor 4 Mus musculus 27-32 31080692-1 2019 Catechol-O-methyltransferase (COMT) is a model S-adenosyl-l-methionine (SAM) dependent methyl transferase, which catalyzes the methylation of catecholamine neurotransmitters such as dopamine in the primary pathway of neurotransmitter deactivation in animals. Catecholamines 142-155 catechol-O-methyltransferase Homo sapiens 0-28 31080692-1 2019 Catechol-O-methyltransferase (COMT) is a model S-adenosyl-l-methionine (SAM) dependent methyl transferase, which catalyzes the methylation of catecholamine neurotransmitters such as dopamine in the primary pathway of neurotransmitter deactivation in animals. Catecholamines 142-155 catechol-O-methyltransferase Homo sapiens 30-34 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 82-95 catechol-O-methyltransferase Homo sapiens 30-34 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 0-28 30896863-10 2019 By inhibiting adrenoreceptor expression, it was demonstrated that beta2-adrenergic receptor (ADRB2) was the specific beta-adrenergic receptor subtype responsible for catecholamine release. Catecholamines 166-179 adrenergic receptor, beta 2 Mus musculus 66-91 31142902-4 2019 Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 30-34 30896863-10 2019 By inhibiting adrenoreceptor expression, it was demonstrated that beta2-adrenergic receptor (ADRB2) was the specific beta-adrenergic receptor subtype responsible for catecholamine release. Catecholamines 166-179 adrenergic receptor, beta 2 Mus musculus 93-98 30933434-13 2019 TNF-alpha induces catecholamine resistance via activation of the Lin28B/let-7a/IKKepsilon pathway. Catecholamines 18-31 tumor necrosis factor Homo sapiens 0-9 30933434-13 2019 TNF-alpha induces catecholamine resistance via activation of the Lin28B/let-7a/IKKepsilon pathway. Catecholamines 18-31 lin-28 homolog B Homo sapiens 65-71 30933434-0 2019 TNF-alpha Upregulates IKKepsilon Expression via the Lin28B/let-7a Pathway to Induce Catecholamine Resistance in Adipocytes. Catecholamines 84-97 tumor necrosis factor Homo sapiens 0-9 30933434-13 2019 TNF-alpha induces catecholamine resistance via activation of the Lin28B/let-7a/IKKepsilon pathway. Catecholamines 18-31 inhibitor of nuclear factor kappa B kinase subunit epsilon Homo sapiens 79-89 30933434-0 2019 TNF-alpha Upregulates IKKepsilon Expression via the Lin28B/let-7a Pathway to Induce Catecholamine Resistance in Adipocytes. Catecholamines 84-97 inhibitor of nuclear factor kappa B kinase subunit epsilon Homo sapiens 22-32 30703415-4 2019 Specifically, in ventricular myocytes, nitric oxide (NO) and cGMP are the intracellular messengers of alpha2-AR signal transduction pathways that gauge the kinase-phosphatase balance and manage cellular Ca2+ handling preventing catecholamine-induced Ca2+ overload. Catecholamines 228-241 adenosine A2a receptor Homo sapiens 102-111 30933434-0 2019 TNF-alpha Upregulates IKKepsilon Expression via the Lin28B/let-7a Pathway to Induce Catecholamine Resistance in Adipocytes. Catecholamines 84-97 lin-28 homolog B Homo sapiens 52-58 30933434-1 2019 OBJECTIVE: Overexpression of inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKKepsilon) contributes to blunted catecholamine-induced lipolysis. Catecholamines 124-137 inhibitor of nuclear factor kappa B kinase subunit epsilon Homo sapiens 89-99 30714474-0 2019 miR-375 mediates the CRF signaling pathway to regulate catecholamine biosynthesis by targeting Sp1 in porcine adrenal gland. Catecholamines 55-68 microRNA 375 Mus musculus 0-7 30711897-2 2019 Two critical regulators of brain IL-1beta production during times of stress are glucocorticoids and catecholamines. Catecholamines 100-114 interleukin 1 alpha Rattus norvegicus 33-41 31019023-10 2019 Thus, propionate may activate a catecholamine-mediated increase in insulin counter-regulatory signals, leading to insulin resistance and hyperinsulinemia, which, over time, may promote adiposity and metabolic abnormalities. Catecholamines 32-45 insulin Homo sapiens 67-74 31035382-9 2019 Correlations with PPGL tissue data led us to conclude that catecholamine biosynthesis under hypoxia is mainly mediated through increased phosphorylation of TH, regulated as a short-term response (24-48 h) by HIF1alpha. Catecholamines 59-72 tyrosine hydroxylase Homo sapiens 156-158 31035382-9 2019 Correlations with PPGL tissue data led us to conclude that catecholamine biosynthesis under hypoxia is mainly mediated through increased phosphorylation of TH, regulated as a short-term response (24-48 h) by HIF1alpha. Catecholamines 59-72 hypoxia inducible factor 1 subunit alpha Homo sapiens 208-217 30658296-9 2019 Cerebral enzymes of mitochondrial respiratory chain complex (COX IV, COX5B), of glycosphingolipid biosynthesis (beta-N-acetylhexosaminidase), involved in catecholamines degradation (catechol O-methyltransferase), and microtubule cytoskeleton (stathmin) were oxidized in WAF-treated specimens. Catecholamines 154-168 catechol O-methyltransferase Oreochromis niloticus 182-210 30824540-0 2019 EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells. Catecholamines 15-28 Eph receptor B6 Mus musculus 0-5 31019023-10 2019 Thus, propionate may activate a catecholamine-mediated increase in insulin counter-regulatory signals, leading to insulin resistance and hyperinsulinemia, which, over time, may promote adiposity and metabolic abnormalities. Catecholamines 32-45 insulin Homo sapiens 114-121 30467710-1 2019 We have previously shown that the chromogranin A (CgA)-derived peptide catestatin (CST: hCgA352-372) inhibits nicotine-induced secretion of catecholamines from the adrenal medulla and chromaffin cells. Catecholamines 140-154 chromogranin A Rattus norvegicus 34-48 30948720-4 2019 This effect of p110alpha inactivation is due to a potentiating effect on beta-adrenergic signalling, which leads to increased catecholamine-induced energy expenditure in the adipose tissue. Catecholamines 126-139 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 15-24 30959789-11 2019 In conclusion, long-term catecholamine overproduction in PPGL leads to the elevation in serum FGF21, especially in patients with secondary diabetes. Catecholamines 25-38 fibroblast growth factor 21 Homo sapiens 94-99 30467710-1 2019 We have previously shown that the chromogranin A (CgA)-derived peptide catestatin (CST: hCgA352-372) inhibits nicotine-induced secretion of catecholamines from the adrenal medulla and chromaffin cells. Catecholamines 140-154 chromogranin A Rattus norvegicus 50-53 30350305-1 2019 Recent literature suggested an important function of native amyloid precursor protein (APP) as amine oxidase implicating in protection of brain cells from catecholamine-induced toxicity. Catecholamines 155-168 amyloid beta precursor protein Homo sapiens 60-85 30747396-1 2019 BACKGROUND: Numerous studies have reported significantly elevated titers of serum autoantibody against the second extracellular loop of beta1-adrenoceptor (beta1-AA), a catecholamine-like substance with beta1-adrenergic activity, in patients with heart failure. Catecholamines 169-182 adrenoceptor beta 1 Homo sapiens 136-154 30784606-1 2019 The Angiotensin II for the Treatment of Vasodilatory Shock (ATHOS-3) trial demonstrated the vasopressor effects and catecholamine-sparing properties of angiotensin II. Catecholamines 116-129 angiotensinogen Homo sapiens 4-18 30784606-1 2019 The Angiotensin II for the Treatment of Vasodilatory Shock (ATHOS-3) trial demonstrated the vasopressor effects and catecholamine-sparing properties of angiotensin II. Catecholamines 116-129 angiotensinogen Homo sapiens 152-166 29995172-3 2019 Tyrosine hydroxylase (TH), tetrahydrobiopterin (BH4)-dependent and iron-containing monooxygenase, catalyzes the conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the initial and rate-limiting step in the biosynthesis of catecholamines (DA, noradrenaline, and adrenaline). Catecholamines 246-260 tyrosine hydroxylase Homo sapiens 0-20 29995172-3 2019 Tyrosine hydroxylase (TH), tetrahydrobiopterin (BH4)-dependent and iron-containing monooxygenase, catalyzes the conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the initial and rate-limiting step in the biosynthesis of catecholamines (DA, noradrenaline, and adrenaline). Catecholamines 246-260 tyrosine hydroxylase Homo sapiens 22-24 29995172-4 2019 PD affects specifically TH-containing catecholamine neurons. Catecholamines 38-51 tyrosine hydroxylase Homo sapiens 24-26 30747396-1 2019 BACKGROUND: Numerous studies have reported significantly elevated titers of serum autoantibody against the second extracellular loop of beta1-adrenoceptor (beta1-AA), a catecholamine-like substance with beta1-adrenergic activity, in patients with heart failure. Catecholamines 169-182 BCL2 related protein A1 Homo sapiens 136-141 30747396-1 2019 BACKGROUND: Numerous studies have reported significantly elevated titers of serum autoantibody against the second extracellular loop of beta1-adrenoceptor (beta1-AA), a catecholamine-like substance with beta1-adrenergic activity, in patients with heart failure. Catecholamines 169-182 BCL2 related protein A1 Homo sapiens 156-161 30690135-2 2019 This neuron loss is accompanied by reduced protein and activity levels of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 74-94 30690135-2 2019 This neuron loss is accompanied by reduced protein and activity levels of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 96-98 30506451-4 2019 RESULTS: Insulin withdrawal increased levels of glucose (6.1 +- 0.5 vs 18.6 +- 0.5 mmol/l), NEFA, 3-OHB (127 +- 18 vs 1837 +- 298 mumol/l), glucagon, cortisol and growth hormone and decreased HCO3- and pH, without affecting catecholamine or cytokine levels. Catecholamines 224-237 insulin Homo sapiens 9-16 30949055-3 2019 Not only are the endogenous ligands catecholamine/serotonin precursors, but GPR139 expressing areas can directly/indirectly regulate the activity of catecholamine/serotonin neurons. Catecholamines 149-162 G protein-coupled receptor 139 Rattus norvegicus 76-82 30871199-6 2019 Moreover, Cbl markedly inhibited the catecholamine release and [Ca2+]i rise caused by hypoxia in isolated CBs and dispersed glomus cells, respectively, whereas it did not alter these responses when they were evoked by high [K+]e. The L-type Ca2+ channel blocker nifedipine slightly inhibited the rise in CB chemoreceptor cells [Ca2+]i elicited by sulfide, whilst causing a somewhat larger attenuation of the hypoxia-induced Ca2+ signal. Catecholamines 37-50 Cbl proto-oncogene Rattus norvegicus 10-13 30795871-0 2019 Synaptobrevin-2 C-Terminal Flexible Region Regulates the Discharge of Catecholamine Molecules. Catecholamines 70-83 vesicle associated membrane protein 2 Homo sapiens 0-15 30738894-14 2019 Taken together, this study elucidates the previously unknown roles of the transcription factors Sp1/Egr1/CREB and microRNAs miR-1224/miR-300 in regulating MAO-B gene expression under basal/disease states involving dysregulated catecholamine levels. Catecholamines 227-240 monoamine oxidase B Homo sapiens 155-160 30792355-5 2019 ent-(+)-verticilide prevented arrhythmogenic membrane depolarizations in cardiomyocytes without significant effects on the cardiac action potential and attenuated ventricular arrhythmia in catecholamine-challenged Casq2-/- mice. Catecholamines 189-202 calsequestrin 2 Mus musculus 214-219 30886568-5 2019 This review focuses on the known mechanisms by which 5-HT and SERT, in coordinated signaling with catecholamines, impacts cigarette smokers" platelet biology. Catecholamines 98-112 solute carrier family 6 member 4 Homo sapiens 62-66 28817438-11 2019 Mechanistically, we show that macrophages recruited to burn-stressed subcutaneous WAT (sWAT) undergo alternative activation to induce tyrosine hydroxylase expression and catecholamine production mediated by IL-6, factors required for browning of sWAT. Catecholamines 170-183 interleukin 6 Homo sapiens 207-211 30361782-1 2019 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamines and has been connected to aggravated progression of periodontal disease under chronic stress. Catecholamines 79-93 tyrosine hydroxylase Homo sapiens 0-20 30361782-1 2019 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamines and has been connected to aggravated progression of periodontal disease under chronic stress. Catecholamines 79-93 tyrosine hydroxylase Homo sapiens 22-24 30468801-13 2019 HuC/D expression in tumors may be related to catecholamine production or a neural crest-derived cell origin. Catecholamines 45-58 ELAV like RNA binding protein 3 Homo sapiens 0-3 30770790-2 2019 The differentiation of nTreg cells is mediated by catecholamines via beta1-adrenergic receptor (beta1-AR) activation. Catecholamines 50-64 adrenoceptor beta 1 Rattus norvegicus 69-94 30304564-2 2019 Renalase is a catecholamine-metabolizing enzyme, which contributes to the occurrence of hypertension. Catecholamines 14-27 renalase, FAD dependent amine oxidase Homo sapiens 0-8 30618146-4 2019 They can show an increase in phosphorylated Stat-3 in the presence of leptin, are electrically excited by the anorectic neuromodulator cholecystokinin, and inhibited by orexigenic neuromodulators neuropeptide Y, met-enkephalin, dynorphin and the catecholamine dopamine. Catecholamines 246-259 signal transducer and activator of transcription 3 Mus musculus 44-50 30101816-6 2019 The present results indicate the possibility that the amount of catecholamines produced in albino mice is higher than that of colored mice due to the deficit in tyrosinase heritably. Catecholamines 64-78 tyrosinase Mus musculus 161-171 30660754-6 2019 For this purpose, the density of DAT, NET, the vesicular monoamine transporter 2 (VMAT2), the rate limiting enzyme for catecholamine synthesis tyrosine hydroxylase (TH) and the dopamine D1 receptor were measured in frontal (FC), parietal cortex (PCx) and the dorsal (DS) and ventral (VS) striatum. Catecholamines 119-132 solute carrier family 6 member 3 Rattus norvegicus 33-36 30660754-6 2019 For this purpose, the density of DAT, NET, the vesicular monoamine transporter 2 (VMAT2), the rate limiting enzyme for catecholamine synthesis tyrosine hydroxylase (TH) and the dopamine D1 receptor were measured in frontal (FC), parietal cortex (PCx) and the dorsal (DS) and ventral (VS) striatum. Catecholamines 119-132 solute carrier family 18 member A2 Rattus norvegicus 82-87 30770790-2 2019 The differentiation of nTreg cells is mediated by catecholamines via beta1-adrenergic receptor (beta1-AR) activation. Catecholamines 50-64 adrenoceptor beta 1 Rattus norvegicus 96-104 30710078-3 2019 Here we show that the SGLT2 inhibitor (SGLT2i) dapagliflozin promotes ketoacidosis in both healthy and type 2 diabetic rats in the setting of insulinopenia through increased plasma catecholamine and corticosterone concentrations secondary to volume depletion. Catecholamines 181-194 solute carrier family 5 member 2 Rattus norvegicus 22-27 30538132-10 2019 Phospho-USP20 was significantly increased in LVs of wildtype (WT) mice after a 1-week catecholamine infusion and a 2-week chronic pressure overload induced by transverse aortic constriction (TAC). Catecholamines 86-99 ubiquitin specific peptidase 20 Mus musculus 8-13 30689738-1 2019 In patients with aromatic l-amino acid decarboxylase (AADC) deficiency, a decrease in catecholamines and serotonin levels in the brain leads to developmental delay and movement disorders. Catecholamines 86-100 dopa decarboxylase Homo sapiens 26-52 30689738-1 2019 In patients with aromatic l-amino acid decarboxylase (AADC) deficiency, a decrease in catecholamines and serotonin levels in the brain leads to developmental delay and movement disorders. Catecholamines 86-100 dopa decarboxylase Homo sapiens 54-58 29908046-8 2019 Vasopressin, angiotensin II, and, paradoxically, alpha2 -adrenergic receptor agonists (clonidine and dexmedetomidine) may be feasible adjunct therapies for catecholamine-resistant vasodilatory shock. Catecholamines 156-169 arginine vasopressin Homo sapiens 0-11 30553769-7 2019 Irs2-deficient macrophages displayed an anti-inflammatory transcriptional profile and alterations in genes involved in scavenging catecholamines and supporting increased sympathetic innervation. Catecholamines 130-144 insulin receptor substrate 2 Mus musculus 0-4 29894763-4 2019 Adrenal chromaffin cells also prominently express SERT where it might coordinate accumulation of 5-HT for reuse in the autocrine control of stress-evoked catecholamine secretion. Catecholamines 154-167 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 50-54 30597665-7 2019 Physiologic replacement with exogenous Arginine vasopressin results in significant increases in systemic vascular resistance and mean arterial pressure with decreased requirements of catecholamines. Catecholamines 183-197 arginine vasopressin Homo sapiens 48-59 30653498-0 2019 Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. Catecholamines 50-64 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 0-28 30653498-0 2019 Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. Catecholamines 50-64 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 30-34 30653498-2 2019 Although previous studies report NE clearance mechanisms via SLC6A2 on sympathetic neurons or proinflammatory macrophages in adipose tissues (ATs), the low catecholamine clearance capacity of SLC6A2 may limit the cleaning efficiency. Catecholamines 156-169 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 192-198 30525590-1 2019 The five dopamine receptor subtypes (D1-5) are activated by the endogenous catecholamine dopamine. Catecholamines 75-88 leiomodin 1 Homo sapiens 37-41 30618378-0 2019 Correction: ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines. Catecholamines 116-130 erb-b2 receptor tyrosine kinase 4 Homo sapiens 12-17 29030055-10 2019 According to the catecholaldehyde hypothesis, 3,4-dihydroxyphenylacetaldehyde (DOPAL), an intermediary metabolite of dopamine, causes or contributes to the death of catecholamine neurons, especially by interacting with proteins such as alpha-synuclein. Catecholamines 165-178 synuclein alpha Homo sapiens 236-251 30727934-6 2019 Although most of the anti-inflammatory effects of catecholamines are mediated by beta adrenergic receptors (particularly beta2), it is not known whether in altered homeostatic conditions, such as obesity and during exercise, innate/inflammatory responses of macrophages to beta2 adrenergic stimulation are similar to those in cells of healthy organisms at baseline. Catecholamines 50-64 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 121-126 30184301-2 2019 Catecholamine producing midbrain and brainstem nuclei are densely connected with the PFC and dACC and exert profound contributions to cognitive control processes. Catecholamines 0-13 Acetyl-CoA carboxylase Drosophila melanogaster 93-97 30692908-2 2018 The role of this catecholamine system is also highlighted by the selective norepinephrine transporter blocking atomoxetine, which has proved to be effective in the pharmacological treatment of Attention Deficit Hyperactivity Disorder (ADHD). Catecholamines 17-30 solute carrier family 6 member 2 Homo sapiens 75-101 30389842-0 2019 An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells. Catecholamines 40-53 calcyphosphine 2 Mus musculus 23-28 30389842-2 2019 A modulatory role of CAPS in catecholamine loading of vesicles has been suggested. Catecholamines 29-42 Ca2+-dependent secretion activator Mus musculus 21-25 30389842-4 2019 Using expression of naturally occurring splice variants of CAPS2 into chromaffin cells from CAPS1/CAPS2 double-deficient mice of both sexes, we show that an alternative exon of 40 aa is responsible for enhanced catecholamine loading of LDCVs in mouse chromaffin cells. Catecholamines 211-224 calcyphosphine 2 Mus musculus 59-64 30389842-4 2019 Using expression of naturally occurring splice variants of CAPS2 into chromaffin cells from CAPS1/CAPS2 double-deficient mice of both sexes, we show that an alternative exon of 40 aa is responsible for enhanced catecholamine loading of LDCVs in mouse chromaffin cells. Catecholamines 211-224 Ca2+-dependent secretion activator Mus musculus 92-97 30389842-4 2019 Using expression of naturally occurring splice variants of CAPS2 into chromaffin cells from CAPS1/CAPS2 double-deficient mice of both sexes, we show that an alternative exon of 40 aa is responsible for enhanced catecholamine loading of LDCVs in mouse chromaffin cells. Catecholamines 211-224 calcyphosphine 2 Mus musculus 98-103 30389842-7 2019 Our results establish a splice-variant-dependent modulatory effect of CAPS on catecholamine content in LDCVs.SIGNIFICANCE STATEMENT The calcium activator protein for secretion (CAPS) promotes and stabilizes the entry of catecholamine-containing vesicles of the adrenal gland into a release-ready state. Catecholamines 78-91 Ca2+-dependent secretion activator Mus musculus 70-74 30389842-7 2019 Our results establish a splice-variant-dependent modulatory effect of CAPS on catecholamine content in LDCVs.SIGNIFICANCE STATEMENT The calcium activator protein for secretion (CAPS) promotes and stabilizes the entry of catecholamine-containing vesicles of the adrenal gland into a release-ready state. Catecholamines 78-91 Ca2+-dependent secretion activator Mus musculus 177-181 30389842-7 2019 Our results establish a splice-variant-dependent modulatory effect of CAPS on catecholamine content in LDCVs.SIGNIFICANCE STATEMENT The calcium activator protein for secretion (CAPS) promotes and stabilizes the entry of catecholamine-containing vesicles of the adrenal gland into a release-ready state. Catecholamines 220-233 Ca2+-dependent secretion activator Mus musculus 70-74 30389842-7 2019 Our results establish a splice-variant-dependent modulatory effect of CAPS on catecholamine content in LDCVs.SIGNIFICANCE STATEMENT The calcium activator protein for secretion (CAPS) promotes and stabilizes the entry of catecholamine-containing vesicles of the adrenal gland into a release-ready state. Catecholamines 220-233 Ca2+-dependent secretion activator Mus musculus 177-181 30389842-8 2019 Expression of an alternatively spliced exon in CAPS leads to enhanced catecholamine content in chromaffin granules. Catecholamines 70-83 Ca2+-dependent secretion activator Mus musculus 47-51 30424994-1 2019 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in degrading catecholamines associated with the stress response, may influence susceptibility to delirium. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 11-39 30424994-1 2019 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in degrading catecholamines associated with the stress response, may influence susceptibility to delirium. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 41-45 30569948-2 2019 The cardiotoxic effects of catecholamines are mediated via prolonged adrenergic receptor stimulation and increased oxidative stress upon their degradation by monoamine oxidase A (MAO-A). Catecholamines 27-41 monoamine oxidase A Rattus norvegicus 158-177 30569948-2 2019 The cardiotoxic effects of catecholamines are mediated via prolonged adrenergic receptor stimulation and increased oxidative stress upon their degradation by monoamine oxidase A (MAO-A). Catecholamines 27-41 monoamine oxidase A Rattus norvegicus 179-184 30597665-10 2019 Exogenous administration of low-dose Arginine vasopressin alone or in combination with traditional catecholamines is a safe and effective way to manage this type of vasodilatory shock. Catecholamines 99-113 arginine vasopressin Homo sapiens 46-57 30411798-1 2019 Tyrosine hydroxylase (TH) is a multi-domain, homo-oligomeric enzyme that catalyses the rate-limiting step of catecholamine neurotransmitter biosynthesis. Catecholamines 109-122 tyrosine hydroxylase Homo sapiens 0-20 30411798-1 2019 Tyrosine hydroxylase (TH) is a multi-domain, homo-oligomeric enzyme that catalyses the rate-limiting step of catecholamine neurotransmitter biosynthesis. Catecholamines 109-122 tyrosine hydroxylase Homo sapiens 22-24 30211780-1 2019 Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 0-28 30542705-1 2019 The beta2-adrenergic receptor (beta2-AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Catecholamines 152-166 adrenoceptor beta 2 Homo sapiens 4-29 30542705-1 2019 The beta2-adrenergic receptor (beta2-AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Catecholamines 152-166 adrenoceptor beta 2 Homo sapiens 31-39 30542705-1 2019 The beta2-adrenergic receptor (beta2-AR, encoded by the ADRB2 gene) is a member of the G-protein-coupled receptor superfamily that can be stimulated by catecholamines. Catecholamines 152-166 adrenoceptor beta 2 Homo sapiens 56-61 30211780-1 2019 Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 30-34 30619056-5 2018 Two ALS patients underwent autopsy and the pathological findings were compatible with the chronological changes identified in catecholamine-induced cardiomyopathy. Catecholamines 126-139 superoxide dismutase 1 Homo sapiens 4-7 30336354-11 2019 The latter is particularly important in conditions such as Parkinson"s disease, where a dopamine precursor is used to treat disease symptoms and highlights that the fate of MAO-A containing dopaminergic neurons may depend on both MAO-A levels and catecholamine substrate availability. Catecholamines 247-260 monoamine oxidase A Homo sapiens 173-178 30619883-3 2018 According to the clinical patterns, arrhythmogenesis in CaM mutations can be attributed, in the majority of cases, to either prolonged repolarization (as in long-QT syndrome, LQTS phenotype), or to instability of the intracellular Ca2+ store (as in catecholamine-induced tachycardias, CPVT phenotype). Catecholamines 249-262 calmodulin 1 Homo sapiens 56-59 29476941-10 2018 In the multivariate analysis, age (P=0.002), history of acute coronary syndrome (P=0.024) and the catecholamine-free days at day 28 (P=0.007) were associated to the increase of perioperative Endocan concentrations. Catecholamines 98-111 endothelial cell specific molecule 1 Homo sapiens 191-198 30155766-1 2018 In chromaffin cells, tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) are mainly involved in catecholamine synthesis. Catecholamines 198-211 phenylethanolamine N-methyltransferase Homo sapiens 129-167 30256128-14 2018 These findings showed that increased C3 induces salt-sensitive hypertension with increases in urinary catecholamine excretion and intrarenal activation of the renin-angiotensin system by the dedifferentiation of mesenchymal tissues in kidney from SHR. Catecholamines 102-115 complement C3 Rattus norvegicus 37-39 30273604-1 2018 alpha2-Adrenergic receptors (alpha2ARs) are G-protein-coupled receptors involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. Catecholamines 84-97 mitogen-activated protein kinase 3 Homo sapiens 111-157 30273604-1 2018 alpha2-Adrenergic receptors (alpha2ARs) are G-protein-coupled receptors involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. Catecholamines 84-97 mitogen-activated protein kinase 3 Homo sapiens 159-165 30155766-8 2018 Lower status of intratumoral AADC could be related to poor differentiation of tumor cells in both catecholamine production and morphology and could be related to aggressive biological behavior of both pheochromocytoma and extraadrenal paraganglioma. Catecholamines 98-111 dopa decarboxylase Homo sapiens 29-33 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 24-49 29981376-1 2018 Patients with chronic overlapping pain conditions have decreased levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Catecholamines 139-153 catechol-O-methyltransferase Mus musculus 75-103 29981376-1 2018 Patients with chronic overlapping pain conditions have decreased levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Catecholamines 139-153 catechol-O-methyltransferase Mus musculus 105-109 30389400-11 2018 Chronic catecholamine stimulation was followed by an enhanced expression of GSK3beta, whereas the phosphorylation at Ser9 was lower in TG as compared to the corresponding WT group. Catecholamines 8-21 glycogen synthase kinase 3 beta Mus musculus 76-84 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 51-59 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 280-288 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 323-329 30538630-2 2018 Catecholamine triggered beta2-adrenergic receptor (beta2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patterns, single nucleotide polymorphisms (SNPs), biased signals, and desensitization of beta2-AR, as well as different subtypes of Galpha binding to beta2-AR. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 280-288 30316938-12 2018 CS complicating TTS may constitute a marker of underlying disease severity and could identify a masked heart failure phenotype with increased vulnerability to catecholamine-mediated myocardial stunning. Catecholamines 159-172 citrate synthase Homo sapiens 0-2 30172948-8 2018 We conclude that the preferential mobilization of NK-cells, non-classical monocytes and differentiated subsets of CD8+ T-cells with exercise is largely dependent on catecholamine signaling through the beta2-AR. Catecholamines 165-178 CD8a molecule Homo sapiens 114-117 30172948-8 2018 We conclude that the preferential mobilization of NK-cells, non-classical monocytes and differentiated subsets of CD8+ T-cells with exercise is largely dependent on catecholamine signaling through the beta2-AR. Catecholamines 165-178 adrenoceptor beta 2 Homo sapiens 201-209 30603941-3 2018 All labeled neurons innervating the stomach contain the catecholamine synthesis enzyme, tyrosine hydroxylase. Catecholamines 56-69 tyrosine hydroxylase Rattus norvegicus 88-108 30364230-8 2018 We find that in addition to dopaminergic neurons within the A11 region, there is another neuronal subtype which expresses the monoenzymatic aromatic L-amino acid decarboxylase (AADC), but not TH, a key enzyme involved in the synthesis of catecholamines including dopamine. Catecholamines 238-252 dopa decarboxylase Mus musculus 149-175 29676198-10 2018 In this case, CMS fibrosis is associated with increased production of catecholamines and with a disruption of renin-angiotensin system balance, which can be prevented by angiotensin II receptor blockade. Catecholamines 70-84 angiotensinogen Rattus norvegicus 170-184 30364230-8 2018 We find that in addition to dopaminergic neurons within the A11 region, there is another neuronal subtype which expresses the monoenzymatic aromatic L-amino acid decarboxylase (AADC), but not TH, a key enzyme involved in the synthesis of catecholamines including dopamine. Catecholamines 238-252 dopa decarboxylase Mus musculus 177-181 20301715-5 1993 Symptoms of PGL/PCC result either from mass effects or catecholamine hypersecretion (e.g., sustained or paroxysmal elevations in blood pressure, headache, episodic profuse sweating, forceful palpitations, pallor, and apprehension or anxiety). Catecholamines 55-68 crystallin gamma D Homo sapiens 16-19 29935309-1 2018 Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Catecholamines 215-229 catechol-O-methyltransferase Rattus norvegicus 152-180 29688923-4 2018 After AT II initiation, there was an immediate reduction in catecholamine requirement, and the patient survived. Catecholamines 60-73 angiotensinogen Homo sapiens 6-11 29935309-1 2018 Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Catecholamines 215-229 catechol-O-methyltransferase Rattus norvegicus 182-186 29850786-3 2018 The sympathetic co-transmitter neuropeptide Y (NPY) is co-released with catecholamines and is a known cardiac modulator and predictor of heart failure mortality. Catecholamines 72-86 neuropeptide Y Mus musculus 31-45 30007012-10 2018 KEY RESULTS: (+-)-Epibatidine-induced elevation of plasma catecholamines was significantly attenuated by L-NAME (non-selective NOS inhibitor), carboxy-PTIO (NO scavenger), BYK191023 [selective inducible NOS (iNOS) inhibitor] and dithiothreitol (thiol-reducing reagent), but not by 3-bromo-7-nitroindazole (selective neuronal NOS inhibitor) or ODQ (sGC inhibitor). Catecholamines 58-72 nitric oxide synthase 2 Rattus norvegicus 193-206 30007012-10 2018 KEY RESULTS: (+-)-Epibatidine-induced elevation of plasma catecholamines was significantly attenuated by L-NAME (non-selective NOS inhibitor), carboxy-PTIO (NO scavenger), BYK191023 [selective inducible NOS (iNOS) inhibitor] and dithiothreitol (thiol-reducing reagent), but not by 3-bromo-7-nitroindazole (selective neuronal NOS inhibitor) or ODQ (sGC inhibitor). Catecholamines 58-72 nitric oxide synthase 2 Rattus norvegicus 208-212 30007012-10 2018 KEY RESULTS: (+-)-Epibatidine-induced elevation of plasma catecholamines was significantly attenuated by L-NAME (non-selective NOS inhibitor), carboxy-PTIO (NO scavenger), BYK191023 [selective inducible NOS (iNOS) inhibitor] and dithiothreitol (thiol-reducing reagent), but not by 3-bromo-7-nitroindazole (selective neuronal NOS inhibitor) or ODQ (sGC inhibitor). Catecholamines 58-72 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 348-351 30007012-12 2018 CONCLUSIONS AND IMPLICATIONS: Stimulation of brain nAChRs can induce elevation of plasma catecholamines through brain iNOS-derived NO-mediated protein S-nitrosylation in rats. Catecholamines 89-103 nitric oxide synthase 2 Rattus norvegicus 118-122 29850786-3 2018 The sympathetic co-transmitter neuropeptide Y (NPY) is co-released with catecholamines and is a known cardiac modulator and predictor of heart failure mortality. Catecholamines 72-86 neuropeptide Y Mus musculus 47-50 29240642-4 2018 The association of weight- and BMI-adjusted vasopressin dose with change in catecholamine dose and change in mean arterial pressure (MAP) were evaluated using Spearman"s correlation. Catecholamines 76-89 arginine vasopressin Homo sapiens 44-55 30004142-4 2018 Some valid candidate genes are RTN4R, that encodes a protein which inhibits axonal sprouting, DGCR8, crucial in mRNA processing, or catechol-O-methyltransferase (COMT) and proline oxydase 1 (PRODH), involved in catecholamine metabolism in frontal cortex. Catecholamines 211-224 reticulon 4 receptor Homo sapiens 31-36 29228345-8 2018 Human studies suggest that EPO administration is also associated with increased responsiveness to catecholamines and angiotensin II on vascular tissue; in addition, hypoxia-induced vasodilation may be impaired in those with EPO-induced hypertension. Catecholamines 98-112 erythropoietin Homo sapiens 27-30 29240642-9 2018 Comparable findings were observed when evaluating correlations between BMI-adjusted vasopressin dose with change in MAP and catecholamine dose at all time points (all P values >0.05). Catecholamines 124-137 arginine vasopressin Homo sapiens 84-95 29966752-8 2018 Taken together our data proposed an inhibitory role of ERK1/2 in the regulation of catecholamine secretion and demonstrated that balance between PKG and ERK1/2 activity could have a substantial impact on the regulation of DA release from the cells. Catecholamines 83-96 mitogen activated protein kinase 3 Rattus norvegicus 55-61 29593014-3 2018 In CHF, chronically elevated circulating catecholamine levels cause pathological remodeling of type-2 ryanodine receptor/Ca2+ release channels resulting in diastolic sarcoplasmic reticulum Ca2+ leak and decreased myocardial contractility. Catecholamines 41-54 ryanodine receptor 2 Homo sapiens 95-120 29593014-4 2018 Similarly, skeletal muscle contraction requires sarcoplasmic reticulum Ca2+ release through type-1 ryanodine receptors (RyR1), and chronically elevated catecholamine levels in CHF cause RyR1-mediated sarcoplasmic reticulum Ca2+ leak, contributing to myopathy and weakness. Catecholamines 152-165 ryanodine receptor 1 Homo sapiens 186-190 30179154-0 2018 ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines. Catecholamines 104-118 erb-b2 receptor tyrosine kinase 4 Mus musculus 0-5 29649477-4 2018 Moreover, distinct proinflammatory cytokines (e.g. IL-1beta, IL-8, ICAM-1 and TNF-alpha) could significantly stimulate the expression levels of the rate-limiting enzymes of catecholamine production in prostate ICCs. Catecholamines 173-186 interleukin 1 beta Mus musculus 51-59 29649477-4 2018 Moreover, distinct proinflammatory cytokines (e.g. IL-1beta, IL-8, ICAM-1 and TNF-alpha) could significantly stimulate the expression levels of the rate-limiting enzymes of catecholamine production in prostate ICCs. Catecholamines 173-186 chemokine (C-X-C motif) ligand 15 Mus musculus 61-65 29649477-4 2018 Moreover, distinct proinflammatory cytokines (e.g. IL-1beta, IL-8, ICAM-1 and TNF-alpha) could significantly stimulate the expression levels of the rate-limiting enzymes of catecholamine production in prostate ICCs. Catecholamines 173-186 intercellular adhesion molecule 1 Mus musculus 67-73 29649477-4 2018 Moreover, distinct proinflammatory cytokines (e.g. IL-1beta, IL-8, ICAM-1 and TNF-alpha) could significantly stimulate the expression levels of the rate-limiting enzymes of catecholamine production in prostate ICCs. Catecholamines 173-186 tumor necrosis factor Mus musculus 78-87 29649477-6 2018 Considering that prostatic catecholamine overactivity serves as an essential etiology of pelvic pain by indirectly stimulating the smooth muscle cell proliferation, or by directly causing muscular spasm, our results collectively suggest that targeting the NF-kappaB, HIF-1alpha and HDACs pathways in prostate ICCs be considered as a new strategy for treatment of chronic pelvic pain syndrome (CPPS) induced by chronic prostatitis (CP). Catecholamines 27-40 hypoxia inducible factor 1, alpha subunit Mus musculus 267-277 30179154-3 2018 Here we find that conditional deletion of ErbB4 in locus coeruleus (LC) NE neurons increases neuronal spontaneous firing through NMDA receptor hyperfunction, and elevates catecholamines in the cerebrospinal fluid (CSF). Catecholamines 171-185 erb-b2 receptor tyrosine kinase 4 Mus musculus 42-47 29752915-9 2018 CONCLUSIONS: BCAA-rich fat-free milk intake enhanced insulin secretion and suppressed muscle protein degradation, but these effects are attenuated by exercise accompanied with increase in catecholamine secretion. Catecholamines 188-201 AT-rich interaction domain 4B Homo sapiens 13-17 29874094-0 2018 Activation of catecholamine neurons in the ventral medulla reduces CCK-induced hypophagia and c-Fos activation in dorsal medullary catecholamine neurons. Catecholamines 14-27 cholecystokinin Rattus norvegicus 67-70 29874094-0 2018 Activation of catecholamine neurons in the ventral medulla reduces CCK-induced hypophagia and c-Fos activation in dorsal medullary catecholamine neurons. Catecholamines 14-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 94-99 29874094-0 2018 Activation of catecholamine neurons in the ventral medulla reduces CCK-induced hypophagia and c-Fos activation in dorsal medullary catecholamine neurons. Catecholamines 131-144 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 94-99 29404959-1 2018 Tyrosine hydroxylase (Th) encodes the rate-limiting enzyme in catecholamine biosynthesis, and the regulation of its transcription is critical for the specification and maintenance of catecholaminergic neuron phenotypes. Catecholamines 62-75 tyrosine hydroxylase Homo sapiens 0-20 29363058-0 2018 Role of the beta3-adrenergic receptor subtype in catecholamine-induced myocardial remodeling. Catecholamines 49-62 adrenoceptor beta 3 Rattus norvegicus 12-37 29404959-1 2018 Tyrosine hydroxylase (Th) encodes the rate-limiting enzyme in catecholamine biosynthesis, and the regulation of its transcription is critical for the specification and maintenance of catecholaminergic neuron phenotypes. Catecholamines 62-75 tyrosine hydroxylase Homo sapiens 22-24 30080182-6 2018 Single activation of the CRR increased the adrenal levels of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine synthesis, but this was prevented by repeated activation. Catecholamines 117-130 tyrosine hydroxylase Mus musculus 61-81 30080182-6 2018 Single activation of the CRR increased the adrenal levels of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine synthesis, but this was prevented by repeated activation. Catecholamines 117-130 tyrosine hydroxylase Mus musculus 83-85 29652095-1 2018 The aim of this study was to determine if weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of the renin angiotensin system (RAS), catecholamines and endothelin-1, and also with an increase in the concentrations of vasodilators. Catecholamines 250-264 membrane metalloendopeptidase Homo sapiens 189-199 30311880-3 2018 Additionally, renalase enzyme destroys catecholamines and mediates the regulation (reduction) of blood pressure. Catecholamines 39-53 renalase, FAD dependent amine oxidase Homo sapiens 14-22 30311880-10 2018 CONCLUSION: SNP elevates NO and renalase levels; thus, administration of renalase preparations, which act in the destruction of catecholamines to contain persistent hypertension that develops in association with catecholamine elevation after CABG surgery, along with SNP and other medications used to lower blood pressure can be an effective therapeutic method to control hypertension. Catecholamines 128-142 renalase, FAD dependent amine oxidase Homo sapiens 73-81 30311880-10 2018 CONCLUSION: SNP elevates NO and renalase levels; thus, administration of renalase preparations, which act in the destruction of catecholamines to contain persistent hypertension that develops in association with catecholamine elevation after CABG surgery, along with SNP and other medications used to lower blood pressure can be an effective therapeutic method to control hypertension. Catecholamines 128-141 renalase, FAD dependent amine oxidase Homo sapiens 73-81 29329694-8 2018 Novel vasopressor agents, such as synthetic human angiotensin II, can increase BP and reduce the need for high doses of catecholamine vasopressors in severe or refractory vasodilatory shock. Catecholamines 120-133 angiotensinogen Homo sapiens 50-64 29877879-3 2018 RECENT FINDINGS: The Angiotensin II for the Treatment of High-Output Shock 3 study evaluated angiotensin II use in patients with high-output, vasodilatory shock and demonstrated reduced background catecholamine doses and improved ability to achieve blood pressure goals associated with the use of angiotensin II. Catecholamines 197-210 angiotensinogen Homo sapiens 21-35 30158547-2 2018 COMT is a protein coding gene located at 22q11.21, and its gene product is a major mammalian enzyme involved in the degradation of catecholamines. Catecholamines 131-145 catechol-O-methyltransferase Homo sapiens 0-4 29953881-0 2018 Structural studies on inhibitory mechanisms of antibiotic, corticosteroid and catecholamine molecules on lactoperoxidase. Catecholamines 78-91 lactoperoxidase Homo sapiens 105-120 29877879-3 2018 RECENT FINDINGS: The Angiotensin II for the Treatment of High-Output Shock 3 study evaluated angiotensin II use in patients with high-output, vasodilatory shock and demonstrated reduced background catecholamine doses and improved ability to achieve blood pressure goals associated with the use of angiotensin II. Catecholamines 197-210 angiotensinogen Homo sapiens 93-107 29148180-12 2018 Treating rats with the pan-Akt inhibitor GSK690693 blocked the induction of Dnmt activity, Dnmt protein expression, and DNA methylation, leading to normalization of AOE gene expression as well as plasma catecholamine levels and blood pressure. Catecholamines 203-216 AKT serine/threonine kinase 1 Rattus norvegicus 27-30 30083784-7 2018 Tyrosine hydroxylase (TH) and solute carrier family 6 member 3 (SLC6A3) were significantly related to the functional terms of catecholamine biosynthetic process and dopamine biosynthetic process. Catecholamines 126-139 solute carrier family 6 member 3 Rattus norvegicus 64-70 29183807-3 2018 Here we hypothesised that neonatal overfeeding similarly affects the sympathomedullary system, testing this by investigating the biochemical function of tyrosine hydroxylase (TH), the first rate-limiting enzyme in the catecholamine synthesis. Catecholamines 218-231 tyrosine hydroxylase Rattus norvegicus 153-173 29848777-1 2018 The beta1-adrenergic receptor (beta1-AR) is a major cardiac G protein-coupled receptor, which mediates cardiac actions of catecholamines and is involved in genesis and treatment of numerous cardiovascular disorders. Catecholamines 122-136 adrenoceptor beta 1 Rattus norvegicus 4-29 29848777-1 2018 The beta1-adrenergic receptor (beta1-AR) is a major cardiac G protein-coupled receptor, which mediates cardiac actions of catecholamines and is involved in genesis and treatment of numerous cardiovascular disorders. Catecholamines 122-136 adrenoceptor beta 1 Rattus norvegicus 31-39 29848777-2 2018 In mammalian cells, catecholamines induce the internalization of the beta1-AR into endosomes and their removal promotes the recycling of the endosomal beta1-AR back to the plasma membrane; however, whether these redistributive processes occur in terminally differentiated cells is unknown. Catecholamines 20-34 adrenoceptor beta 1 Homo sapiens 69-77 29794381-10 2018 Suppression of catecholamine-p53 signaling is crucial for inhibition of remodeling in the failing heart. Catecholamines 15-28 transformation related protein 53, pseudogene Mus musculus 29-32 29760304-4 2018 Moreover, his ACTH/cortisol ratio and catecholamine levels were extremely high, suggesting catecholamine-dominant ACTH-secreting pheochromocytoma. Catecholamines 91-104 proopiomelanocortin Homo sapiens 14-18 29760304-4 2018 Moreover, his ACTH/cortisol ratio and catecholamine levels were extremely high, suggesting catecholamine-dominant ACTH-secreting pheochromocytoma. Catecholamines 91-104 proopiomelanocortin Homo sapiens 114-118 29958804-5 2018 Granulocyte macrophage progenitors (GMPs) expressed the beta2 adrenergic receptor, a target of catecholamines. Catecholamines 95-109 adrenoceptor beta 2 Homo sapiens 56-81 29958804-8 2018 Taken together, our study demonstrates that catecholamines produced by leukocytes and sympathetic nerve termini promote GMP proliferation and myeloid cell development. Catecholamines 44-58 5'-nucleotidase, cytosolic II Mus musculus 120-123 29751997-3 2018 We have previously reported that nesfatin-1 causes an increase in blood pressure in normotensive and hypotensive rats by increasing plasma catecholamine, vasopressin, and renin levels. Catecholamines 139-152 nucleobindin 2 Rattus norvegicus 33-43 29183807-3 2018 Here we hypothesised that neonatal overfeeding similarly affects the sympathomedullary system, testing this by investigating the biochemical function of tyrosine hydroxylase (TH), the first rate-limiting enzyme in the catecholamine synthesis. Catecholamines 218-231 tyrosine hydroxylase Rattus norvegicus 175-177 29556684-3 2018 We investigated whether isoprenaline infusion induces PDE2 to decrease the chronotropic and inotropic effects of catecholamines in rat heart. Catecholamines 113-127 phosphodiesterase 2A Rattus norvegicus 54-58 29217488-1 2018 Co-localization of the expression of the dopamine transporter (DAT) with the catecholamine synthesising enzyme tyrosine hydroxylase (TH) has been investigated using transgenic mice expressing Cre recombinase (Cre) dependent green fluorescent protein (GFP) under the control of the DAT promoter (DATIREScre/GFP). Catecholamines 77-90 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 63-66 29977594-1 2018 Background: Pheochromocytomas and Paragangliomas (PCC/PGL) are rare endocrine tumors that are mostly benign, but often hormone producing, causing significant morbidity and mortality due to excess catecholamine secretion and cardiovascular crises. Catecholamines 196-209 crystallin gamma D Homo sapiens 50-53 29879378-6 2018 Surviving Mrap-/- mice developed isolated GC deficiency with normal mineralocorticoid and catecholamine production, recapitulating FGD2. Catecholamines 90-103 melanocortin 2 receptor accessory protein Mus musculus 10-14 29996472-2 2018 Previously, we demonstrated that ERK5 is essential for neurite outgrowth and catecholamine biosynthesis in PC12 cells and sympathetic neurons. Catecholamines 77-90 mitogen-activated protein kinase 7 Rattus norvegicus 33-37 29505301-3 2018 Among the 3 identified mammalian homologs of CRTCs, CRTC3 has been shown to be expressed predominantly in adipose tissues in response to catecholamine signals that regulate lipid metabolism. Catecholamines 137-150 CREB regulated transcription coactivator 3 Homo sapiens 52-57 29941879-0 2018 TNF inhibits catecholamine production from induced sympathetic neuron-like cells in rheumatoid arthritis and osteoarthritis in vitro. Catecholamines 13-26 tumor necrosis factor Homo sapiens 0-3 29941879-8 2018 In mixed synovial cells, significant effects of TNF on catecholamine release were observed only in OA. Catecholamines 55-68 tumor necrosis factor Homo sapiens 48-51 29661830-4 2018 In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner. Catecholamines 15-29 brain derived neurotrophic factor Homo sapiens 52-85 29661830-4 2018 In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner. Catecholamines 15-29 brain derived neurotrophic factor Homo sapiens 87-91 29661830-4 2018 In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner. Catecholamines 15-29 adrenoceptor beta 3 Homo sapiens 99-104 29661830-4 2018 In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner. Catecholamines 15-29 cathelicidin antimicrobial peptide Homo sapiens 105-109 29661830-4 2018 In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner. Catecholamines 15-29 Rap guanine nucleotide exchange factor 3 Homo sapiens 110-114 29661830-4 2018 In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner. Catecholamines 15-29 mitogen-activated protein kinase 8 Homo sapiens 115-118 29801010-19 2018 Conclusions and Relevance: In this systematic review and meta-analysis, the addition of vasopressin to catecholamine vasopressors compared with catecholamines alone was associated with a lower risk of atrial fibrillation. Catecholamines 103-116 arginine vasopressin Homo sapiens 88-99 29601855-0 2018 EGR-1 Expression in Catecholamine-synthesizing Neurons Reflects Auditory Learning and Correlates with Responses in Auditory Processing Areas. Catecholamines 20-33 early growth response 1 Homo sapiens 0-5 29601855-6 2018 The pattern of EGR-1 expression in the locus coeruleus was similar to that observed in two auditory processing areas implicated in auditory learning and memory, namely the caudomedial nidopallium (NCM) and the caudal medial mesopallium (CMM), suggesting a contribution of catecholamines to sensory processing. Catecholamines 272-286 early growth response 1 Homo sapiens 15-20 29743680-3 2018 Renalase, released from kidney, metabolizes catecholamines and regulates blood pressure. Catecholamines 44-58 renalase, FAD dependent amine oxidase Homo sapiens 0-8 29496635-0 2018 Quantitative Analysis of Catecholamines in the Pink1 -/- Rat Model of Early-onset Parkinson"s Disease. Catecholamines 25-39 PTEN induced kinase 1 Rattus norvegicus 47-52 29524394-6 2018 Purified SULT1A3 allozymes exhibited differential sulfating activity toward catecholamines and serotonin. Catecholamines 76-90 sulfotransferase family 1A member 3 Homo sapiens 9-16 29720499-8 2018 During catecholamine stimulation with isoproterenol, T-CaM reduced isoproterenol-promoted diastolic Ca waves in isolated CPVT cardiomyocytes. Catecholamines 7-20 calmodulin 2 Mus musculus 55-58 29524394-0 2018 Sulfation of catecholamines and serotonin by SULT1A3 allozymes. Catecholamines 13-27 sulfotransferase family 1A member 3 Homo sapiens 45-52 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 41-55 catechol-O-methyltransferase Homo sapiens 134-162 29597876-10 2018 It indicated that the beta-adrenoceptor activation resulting from catecholamine release was mainly responsible for the relating changes of electrophysiology of AMPKalpha2-/-. Catecholamines 66-79 protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus 160-170 29597876-12 2018 Impact statement As far as we know, this is the first time the role of AMP-activated protein kinase-alpha2 (AMPKalpha2) on the cardiac electrophysiology is explored, and we found that the beta-adrenoceptor activation resulting from catecholamine release was mainly responsible for the changes of electrophysiology related to the absence of AMPKalpha2. Catecholamines 232-245 protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus 71-106 29597876-12 2018 Impact statement As far as we know, this is the first time the role of AMP-activated protein kinase-alpha2 (AMPKalpha2) on the cardiac electrophysiology is explored, and we found that the beta-adrenoceptor activation resulting from catecholamine release was mainly responsible for the changes of electrophysiology related to the absence of AMPKalpha2. Catecholamines 232-245 protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus 108-118 29597876-12 2018 Impact statement As far as we know, this is the first time the role of AMP-activated protein kinase-alpha2 (AMPKalpha2) on the cardiac electrophysiology is explored, and we found that the beta-adrenoceptor activation resulting from catecholamine release was mainly responsible for the changes of electrophysiology related to the absence of AMPKalpha2. Catecholamines 232-245 protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus 340-350 29389743-2 2018 CHGA is critical for granulogenesis and exocytosis of catecholamine stores from secretory large dense core vesicles (LDCV). Catecholamines 54-67 chromogranin A Mus musculus 0-4 29686031-10 2018 CONCLUSIONS: Downregulation of DDC and D2R in trophoblasts of RMs reflects a reduced signal cascade of catecholamines on the foetal side. Catecholamines 103-117 dopa decarboxylase Homo sapiens 31-34 29686031-10 2018 CONCLUSIONS: Downregulation of DDC and D2R in trophoblasts of RMs reflects a reduced signal cascade of catecholamines on the foetal side. Catecholamines 103-117 dopamine receptor D2 Homo sapiens 39-42 29279477-0 2018 Decreased Serum Adiponectin Level during Catecholamine Crisis in an Obese Patient with Pheochromocytoma. Catecholamines 41-54 adiponectin, C1Q and collagen domain containing Homo sapiens 16-27 29279477-1 2018 We herein report the case of a 37-year-old man with both pheochromocytoma and visceral fat accumulation and describe the sequential changes in his adiponectin levels throughout the clinical course from catecholamine crisis until the follow-up for adrenalectomy. Catecholamines 202-215 adiponectin, C1Q and collagen domain containing Homo sapiens 147-158 29279477-2 2018 His adiponectin level decreased during catecholamine crisis and increased after adrenalectomy. Catecholamines 39-52 adiponectin, C1Q and collagen domain containing Homo sapiens 4-15 29279477-4 2018 This case suggests that catecholamines and visceral fat volume may affect adiponectin metabolism in subjects with pheochromocytoma, which may precipitate cardiovascular complications in this endocrine disease. Catecholamines 24-38 adiponectin, C1Q and collagen domain containing Homo sapiens 74-85 29496998-6 2018 To validate the data resource, we identified tyrosine hydroxylase (Th), a key enzyme in catecholamine synthesis, as a protein that is highly expressed in beta-cells of PWK and CAST islets. Catecholamines 88-101 tyrosine hydroxylase Mus musculus 45-65 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 41-55 catechol-O-methyltransferase Homo sapiens 164-168 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 134-162 29677196-3 2018 Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants" mindsets about stress. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 164-168 29360991-0 2018 Elevated plasma catecholamines functionally compensate for the reduced myogenic tone in smooth muscle STIM1 knockout mice but with deleterious cardiac effects. Catecholamines 16-30 stromal interaction molecule 1 Mus musculus 102-107 29360991-8 2018 Consistent with these findings, plasma catecholamine levels were higher in sm-STIM1 KO than in control mice. Catecholamines 39-52 stromal interaction molecule 1 Mus musculus 78-83 28374858-2 2018 SULT1A3/4 are important enzymes in the metabolism of catecholamines linked to neurodegenerative diseases such as Parkinson"s and Alzheimer"s. Catecholamines 53-67 sulfotransferase family 1A member 3 Homo sapiens 0-9 29569847-5 2018 Albumin, vasopressin and hydrocortisone have each been shown to support blood pressure and reduce catecholamine requirements but without effect on mortality, and as such should be considered for ED patients with septic shock on a case-by-case basis. Catecholamines 98-111 albumin Homo sapiens 0-7 29569847-5 2018 Albumin, vasopressin and hydrocortisone have each been shown to support blood pressure and reduce catecholamine requirements but without effect on mortality, and as such should be considered for ED patients with septic shock on a case-by-case basis. Catecholamines 98-111 arginine vasopressin Homo sapiens 9-20 29343526-9 2018 The CYB561 protein defect leads to a shortage of ascorbate inside the catecholamine secretory vesicles leading to a functional dopamine beta-hydroxylase deficiency. Catecholamines 70-83 cytochrome b561 Homo sapiens 4-10 29999126-2 2018 In response to an acute injury, high levels of counterregulatory hormones such as glucocorticoids and catecholamines are released causing increased hepatic gluconeogenesis and insulin resistance. Catecholamines 102-116 insulin Homo sapiens 176-183 29378832-0 2018 Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Catecholamines 103-116 C2 calcium-dependent domain containing 5 Mus musculus 29-35 29378832-5 2018 Compared with WT controls, CDP138-/- mice had altered catecholamine levels in circulation, adrenal gland, and inguinal fat. Catecholamines 54-67 C2 calcium-dependent domain containing 5 Mus musculus 27-33 29378832-9 2018 Our data indicate that CDP138 is a regulator of stress response and plays a significant role in adipose tissue browning, energy balance, and insulin sensitivity through regulating catecholamine secretion from the sympathetic nervous terminals and adrenal gland. Catecholamines 180-193 C2 calcium-dependent domain containing 5 Mus musculus 23-29 29593559-10 2018 These results suggest that even though ghrelin only partially inhibited the large CPB induced increase in catecholamines and organ macrophage infiltration, it reduced oxidative stress and subsequent cell damage. Catecholamines 106-120 ghrelin and obestatin prepropeptide Rattus norvegicus 39-46 29310047-1 2018 Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. Catecholamines 150-164 catechol-O-methyltransferase Rattus norvegicus 21-50 29310047-1 2018 Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of catecholamines may be a critical component of the neuropathology of alcoholism. Catecholamines 150-164 catechol-O-methyltransferase Rattus norvegicus 52-56 29460135-0 2018 Simvastatin reduces adrenal catecholamine secretion evoked by stimulation of cholinergic nicotinic and angiotensinergic AT1 receptors. Catecholamines 28-41 angiotensin II receptor, type 1a Rattus norvegicus 120-123 29288726-5 2018 PNMT, the terminal enzyme in the catecholamine biosynthetic pathway, directly responsible for adrenaline synthesis, is elevated in hypertensive animals. Catecholamines 33-46 phenylethanolamine N-methyltransferase Homo sapiens 0-4 29951630-10 2018 Conclusion: If an SDHB germline mutation is identified in a patient with HNPGL, the clinician should be aware of the variable manifestations of the SDHB-linked tumour syndrome, the risk of catecholamine excess, concurrent phaeochromocytoma, and association with non-paraganglionic tumours. Catecholamines 189-202 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 18-22 29426301-1 2018 BACKGROUND: The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 16-44 29426301-1 2018 BACKGROUND: The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 46-50 29426301-2 2018 Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogenous catecholamines. Catecholamines 117-131 catechol-O-methyltransferase Homo sapiens 32-36 30877824-5 2018 All labeled neurons innervating the stomach contain the catecholamine synthesis enzyme, tyrosine hydroxylase. Catecholamines 56-69 tyrosine hydroxylase Rattus norvegicus 88-108 29089189-1 2018 Vasopressin is a potent vasopressor used for improving organ perfusion during cardiac arrest, septic and catecholamine-resistant shock; with reference to this, it is useful for the treatment of vasoplegic shock because, restoring organ perfusion pressure by contraction of vascular smooth muscle through a non-catecholamine receptor pathway, it can be employed when catecholamines are ineffective. Catecholamines 105-118 arginine vasopressin Homo sapiens 0-11 29089189-1 2018 Vasopressin is a potent vasopressor used for improving organ perfusion during cardiac arrest, septic and catecholamine-resistant shock; with reference to this, it is useful for the treatment of vasoplegic shock because, restoring organ perfusion pressure by contraction of vascular smooth muscle through a non-catecholamine receptor pathway, it can be employed when catecholamines are ineffective. Catecholamines 366-380 arginine vasopressin Homo sapiens 0-11 29089189-4 2018 Only the vasopressin infusion, in association with catecholamines, gradually stabilized the patient"s hemodynamic status. Catecholamines 51-65 arginine vasopressin Homo sapiens 9-20 28864717-9 2018 CONCLUSION: The increased regional WO rate of [11C]mHED in the lateral LV suggests an imbalance of presynaptic catecholamine reuptake and release, resulting in a higher synaptic catecholamine concentration, in particular in LQT1 patients. Catecholamines 111-124 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 224-228 29246838-8 2018 The insecticide showed the TH transcription-facilitating ability at the concentrations of 3 and 30 muM, at which acetylcholine is known to produce physiological responses, including catecholamine secretion through the nAChRs in adrenal chromaffin cells. Catecholamines 182-195 tyrosine hydroxylase Rattus norvegicus 27-29 29339804-2 2018 We previously demonstrated that EPHB6 knockout reduces catecholamine secretion in male but not female mice, and castration reverses this phenotype. Catecholamines 55-68 Eph receptor B6 Mus musculus 32-37 29309579-0 2018 DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis. Catecholamines 104-117 Parkinsonism associated deglycase Homo sapiens 0-4 29594134-1 2018 Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Catecholamines 213-226 catechol-O-methyltransferase Homo sapiens 16-44 29594134-1 2018 Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Catecholamines 213-226 catechol-O-methyltransferase Homo sapiens 46-50 29594134-8 2018 Conclusion: This preliminary study suggests that arousal and positive valence are influenced in a linear fashion by COMT, presumably due to increased catecholamine in frontal regions, but these findings require replication in a larger sample. Catecholamines 150-163 catechol-O-methyltransferase Homo sapiens 116-120 28801784-7 2018 Induction of non-sympathetic catecholamine production demonstrated by elevated TH and PNMT (phenylethanolamine N-methyltransferase) mRNAs was observed after 7-day cold; however, prior IMO attenuated this response. Catecholamines 29-42 phenylethanolamine-N-methyltransferase Rattus norvegicus 86-90 29063982-1 2018 In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (beta-ARs), mainly the beta 1 (beta1-AR) and beta 2 (beta2-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. Catecholamines 14-27 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 108-114 28801784-7 2018 Induction of non-sympathetic catecholamine production demonstrated by elevated TH and PNMT (phenylethanolamine N-methyltransferase) mRNAs was observed after 7-day cold; however, prior IMO attenuated this response. Catecholamines 29-42 phenylethanolamine-N-methyltransferase Rattus norvegicus 92-130 29063982-1 2018 In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (beta-ARs), mainly the beta 1 (beta1-AR) and beta 2 (beta2-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. Catecholamines 14-27 adrenoceptor beta 1 Homo sapiens 116-124 30517913-2 2018 We studied whether morphine-induced changes in mRNA levels of the catecholamine biosynthesis enzyme, tyrosine hydroxylase (TH), are associated with histone modifications around the promoter of this gene in the locus coeruleus (LC) and ventral tegmental area (VTA) of rats. Catecholamines 66-79 tyrosine hydroxylase Rattus norvegicus 101-121 29063982-1 2018 In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (beta-ARs), mainly the beta 1 (beta1-AR) and beta 2 (beta2-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. Catecholamines 14-27 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 130-136 29063982-1 2018 In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (beta-ARs), mainly the beta 1 (beta1-AR) and beta 2 (beta2-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. Catecholamines 14-27 adrenoceptor beta 2 Homo sapiens 138-146 28389415-3 2018 Key mediators of cardiovascular function (such as catecholamines or angiotensin II) and components of the systemic milieu altered in insulin resistance conditions converge in increasing GRK2 levels in diverse cardiovascular cell types. Catecholamines 50-64 G protein-coupled receptor kinase 2 Homo sapiens 186-190 30517913-2 2018 We studied whether morphine-induced changes in mRNA levels of the catecholamine biosynthesis enzyme, tyrosine hydroxylase (TH), are associated with histone modifications around the promoter of this gene in the locus coeruleus (LC) and ventral tegmental area (VTA) of rats. Catecholamines 66-79 tyrosine hydroxylase Rattus norvegicus 123-125 28983964-1 2018 Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat cortical astrocytes by catecholamines norepinephrine and dopamine as well as selective alpha1 and beta adrenergic agonists. Catecholamines 105-119 brain-derived neurotrophic factor Rattus norvegicus 14-47 28983964-1 2018 Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat cortical astrocytes by catecholamines norepinephrine and dopamine as well as selective alpha1 and beta adrenergic agonists. Catecholamines 105-119 brain-derived neurotrophic factor Rattus norvegicus 49-53 28983964-5 2018 We also show that regulation of BDNF promoters IV and VI by catecholamines requires a distal regulatory element in the BDNF locus. Catecholamines 60-74 brain-derived neurotrophic factor Rattus norvegicus 32-36 28983964-5 2018 We also show that regulation of BDNF promoters IV and VI by catecholamines requires a distal regulatory element in the BDNF locus. Catecholamines 60-74 brain-derived neurotrophic factor Rattus norvegicus 119-123 29455206-11 2018 CONCLUSIONS: MKP-1 may have a role in catecholamine-induced suppression of innate immunity, and exogenous catecholamines might contribute to nosocomial infection risk. Catecholamines 38-51 dual specificity phosphatase 1 Homo sapiens 13-18 28940209-8 2018 By inducing a response of monocytes/macrophages driven by the CCL2/CCR2 axis, stress-related catecholamine may act as a crucial factor in regulating the pre-metastatic niche for and lung colonization by tumor cells. Catecholamines 93-106 chemokine (C-C motif) ligand 2 Mus musculus 62-66 29455206-6 2018 We inhibited MKP-1 activity to determine its role in catecholamine-induced immune suppression. Catecholamines 53-66 dual specificity phosphatase 1 Homo sapiens 13-18 27866280-1 2018 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 0-20 27866280-1 2018 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 22-24 27866280-1 2018 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 156-170 tyrosine hydroxylase Rattus norvegicus 0-20 27866280-1 2018 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 156-170 tyrosine hydroxylase Rattus norvegicus 22-24 28940209-8 2018 By inducing a response of monocytes/macrophages driven by the CCL2/CCR2 axis, stress-related catecholamine may act as a crucial factor in regulating the pre-metastatic niche for and lung colonization by tumor cells. Catecholamines 93-106 chemokine (C-C motif) receptor 2 Mus musculus 67-71 30504710-6 2018 FGF23 formation and/or release are stimulated by 1,25(OH)2D3, phosphate excess, Ca2+, PTH, leptin, catecholamines, mineralocorticoids, volume depletion, lithium, high fat diet, iron deficiency, TNFalpha and TGFss2. Catecholamines 99-113 fibroblast growth factor 23 Homo sapiens 0-5 29944173-1 2018 BACKGROUND: Renalase is a catecholamine-metabolising enzyme, but its possible association with atrial fibrillation (AF) remains unknown. Catecholamines 26-39 renalase, FAD dependent amine oxidase Homo sapiens 12-20 29212953-4 2017 Genes involved in catecholamine biosynthesis and cAMP signaling are upregulated in the adrenal glands of Siah1a-/- mice, while genes related to retinoic acid signaling and cholesterol biosynthesis are downregulated. Catecholamines 18-31 siah E3 ubiquitin protein ligase 1A Mus musculus 105-111 28875377-2 2018 In the mid-1960s, the enzymatically inactive, major core protein, chromogranin A was shown to be exocytotically discharged from the stimulated adrenal gland in parallel with the co-stored catecholamines and ATP. Catecholamines 188-202 chromogranin A Homo sapiens 66-80 29058146-9 2018 Finally, we have also investigated the effect of nAChR-targeted tobacco cessation drugs on catecholamine release in chromaffin cells. Catecholamines 91-104 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 49-54 29331395-4 2018 Given that the loss of dopamine, and its rate-limiting enzyme tyrosine hydroxylase (TH) occurs in PD, the expression and accompanying post-translational changes in TH during PD progression could yield insight into the disruption of cellular signalling occurring in the CNS, and also in peripheral tissues wherein catecholamine function plays a role. Catecholamines 313-326 tyrosine hydroxylase Homo sapiens 84-86 29331395-4 2018 Given that the loss of dopamine, and its rate-limiting enzyme tyrosine hydroxylase (TH) occurs in PD, the expression and accompanying post-translational changes in TH during PD progression could yield insight into the disruption of cellular signalling occurring in the CNS, and also in peripheral tissues wherein catecholamine function plays a role. Catecholamines 313-326 tyrosine hydroxylase Homo sapiens 164-166 28674848-13 2017 In univariate analysis, ESBL acquisition was associated with male gender, SAPS II, SOFA, chronic kidney disease at admission, duration of mechanical ventilation, need for catecholamine and the ICU LOS. Catecholamines 171-184 EsbL Escherichia coli 24-28 29270116-11 2017 These data provide insight into the potential influences of COMT-regulated variations in catecholamine levels on brain function, which may represent endophenotypes for disorders of impulsivity. Catecholamines 89-102 catechol-O-methyltransferase Homo sapiens 60-64 28953873-5 2017 Unexpectedly, unbiased whole-transcriptome analyses of adipose macrophages revealed that ageing upregulates genes that control catecholamine degradation in an NLRP3 inflammasome-dependent manner. Catecholamines 127-140 NLR family, pyrin domain containing 3 Mus musculus 159-164 28844929-2 2017 COMT methylates and thus inactivates catecholamine neurotransmitters and metabolizes xenobiotic catechols. Catecholamines 37-50 catechol-O-methyltransferase b Danio rerio 0-4 29192066-1 2017 Catecholamines stimulate interleukin-6 (IL-6) secretion in skeletal muscles. Catecholamines 0-14 interleukin 6 Mus musculus 25-38 29192066-1 2017 Catecholamines stimulate interleukin-6 (IL-6) secretion in skeletal muscles. Catecholamines 0-14 interleukin 6 Mus musculus 40-44 28583436-0 2017 Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise. Catecholamines 86-100 fatty acid binding protein 4 Homo sapiens 16-44 28754379-12 2017 Taken together, the data obtained suggest that beta2-adrenoceptor-induced modulation of TG2 represents a novel paradigm in beta2-adrenoceptor cell signalling, expanding the repertoire of cellular functions responsive to catecholamine stimulation. Catecholamines 220-233 adrenoceptor beta 2 Rattus norvegicus 47-65 28754379-12 2017 Taken together, the data obtained suggest that beta2-adrenoceptor-induced modulation of TG2 represents a novel paradigm in beta2-adrenoceptor cell signalling, expanding the repertoire of cellular functions responsive to catecholamine stimulation. Catecholamines 220-233 transglutaminase 2 Rattus norvegicus 88-91 28754379-12 2017 Taken together, the data obtained suggest that beta2-adrenoceptor-induced modulation of TG2 represents a novel paradigm in beta2-adrenoceptor cell signalling, expanding the repertoire of cellular functions responsive to catecholamine stimulation. Catecholamines 220-233 adrenoceptor beta 2 Rattus norvegicus 123-141 28844929-8 2017 Treatment of larval zebrafish with the COMT inhibitor Ro41-0960 shifted the balance of catecholamine metabolic pathways towards increased oxidative metabolism. Catecholamines 87-100 catechol-O-methyltransferase b Danio rerio 39-43 28844929-10 2017 Thus, COMT is likely to participate in the processing of catecholamine neurotransmitters in the zebrafish, but the inhibition of COMT in larval fish is compensated efficiently and does not have pronounced effects on dopamine levels. Catecholamines 57-70 catechol-O-methyltransferase b Danio rerio 6-10 28120550-2 2017 In humans and dogs they have many similarities: the excessive catecholamine release in hormonally active PCC causes similar clinical signs, the frequency of metastasis is similar, and they are histopathologically almost identical. Catecholamines 62-75 crystallin gamma D Homo sapiens 105-108 29032653-2 2017 Specifically, hormone-sensitive lipase (HSL) is an intracellular lipase that can be stimulated by several hormones, such as catecholamine, glucagon, and adrenocorticotropic hormone. Catecholamines 124-137 lipase E, hormone sensitive type Homo sapiens 14-38 29032653-2 2017 Specifically, hormone-sensitive lipase (HSL) is an intracellular lipase that can be stimulated by several hormones, such as catecholamine, glucagon, and adrenocorticotropic hormone. Catecholamines 124-137 lipase E, hormone sensitive type Homo sapiens 40-43 28819071-1 2017 Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S)-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethylamine). Catecholamines 274-287 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 0-42 28819071-1 2017 Hepatic flavin-containing mono-oxygenase 3 (FMO3) metabolizes a broad array of nucleophilic heteroatom (e.g., N or S)-containing xenobiotics (e.g., amphetamine, sulindac, benzydamine, ranitidine, tamoxifen, nicotine, and ethionamide), as well as endogenous compounds (e.g., catecholamine and trimethylamine). Catecholamines 274-287 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 44-48 29065134-1 2017 Renalase decreases circulating catecholamines concentration and is important in maintaining primary cellular metabolism. Catecholamines 31-45 renalase, FAD dependent amine oxidase Homo sapiens 0-8 29016861-0 2017 DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis. Catecholamines 104-117 Parkinsonism associated deglycase Homo sapiens 0-4 29016861-6 2017 RNA sequencing indicated that oxidative changes to DJ-1 were concomitant with changes in mRNA transcripts mainly involved in catecholamine metabolism. Catecholamines 125-138 Parkinsonism associated deglycase Homo sapiens 51-55 29016861-8 2017 In the KD model, the absence of DJ-1 complexes was accompanied by impairment in catecholamine homeostasis, with significant increases in intracellular DA and noraderenaline levels. Catecholamines 80-93 Parkinsonism associated deglycase Homo sapiens 32-36 29016861-9 2017 These changes in catecholamines could be rescued by re-expression of DJ-1. Catecholamines 17-31 Parkinsonism associated deglycase Homo sapiens 69-73 29016861-10 2017 This catecholamine imbalance may contribute to the particular vulnerability of dopaminergic and noradrenergic neurons to neurodegeneration in PARK7-related PD. Catecholamines 5-18 Parkinsonism associated deglycase Homo sapiens 142-147 28953873-6 2017 Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline. Catecholamines 37-50 NLR family, pyrin domain containing 3 Mus musculus 12-17 28953873-6 2017 Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline. Catecholamines 37-50 growth differentiation factor 3 Mus musculus 87-118 28953873-6 2017 Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline. Catecholamines 37-50 growth differentiation factor 3 Mus musculus 120-124 28953873-6 2017 Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline. Catecholamines 37-50 monoamine oxidase A Mus musculus 130-149 28953873-6 2017 Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline. Catecholamines 37-50 monoamine oxidase A Mus musculus 151-155 28701322-5 2017 Approximately one-third of AT1AR-expressing neurons express the catecholamine-synthetic enzyme tyrosine hydroxylase (TH), and a subpopulation of these stained for the transcription factor paired-like homeobox 2b (Phox2b). Catecholamines 64-77 angiotensin II receptor type 1 Homo sapiens 27-32 28274841-4 2017 Despite having severe obesity, subjects with MC4R deficiency exhibit reductions in BP, heart rate, and urinary catecholamine excretion, as well as attenuated SNS responses to cold stimuli compared to obese subjects with normal MC4R function. Catecholamines 111-124 melanocortin 4 receptor Homo sapiens 45-49 28835457-4 2017 In this study, we describe the role of catecholamines (as mediators of the sympathetic nervous system) related to IL-27 production in primary mouse macrophages. Catecholamines 39-53 interleukin 27 Mus musculus 114-119 28837972-1 2017 Catecholamines stimulate renin-secretion in the juxtaglomerular cells of the kidney and a number of case reports suggest an association between pheochromocytoma and activation of the RAAS. Catecholamines 0-14 renin Homo sapiens 25-30 28837972-2 2017 Therefore, it could be asked whether patients suffering from pheochromocytoma with high concentrations of circulating catecholamines present with oversecretion of renin and aldosterone. Catecholamines 118-132 renin Homo sapiens 163-168 28835457-11 2017 Conversely, IL-27p28 was 2.7-fold increased by removal of the catecholamine-producing adrenal glands prior to endotoxic shock. Catecholamines 62-75 interleukin 27 Mus musculus 12-20 28667172-1 2017 The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. Catecholamines 76-90 chromogranin A Homo sapiens 24-38 29087480-0 2017 Myeloid adrenergic signaling via CaMKII forms a feedforward loop of catecholamine biosynthesis. Catecholamines 68-81 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 33-39 29087480-8 2017 Lack of CaMKII signaling attenuated catecholamine production mediated by cytokines IL-4 and IL-13, key inducers of type 2 immune response in primary macrophages. Catecholamines 36-49 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 8-14 29087480-8 2017 Lack of CaMKII signaling attenuated catecholamine production mediated by cytokines IL-4 and IL-13, key inducers of type 2 immune response in primary macrophages. Catecholamines 36-49 interleukin 4 Mus musculus 83-87 29087480-8 2017 Lack of CaMKII signaling attenuated catecholamine production mediated by cytokines IL-4 and IL-13, key inducers of type 2 immune response in primary macrophages. Catecholamines 36-49 interleukin 13 Mus musculus 92-97 29087480-9 2017 Taken together, these results suggest a feedforward mechanism of adrenaline in adipose-resident macrophages, and that myeloid CaMKII signaling plays an important role in catecholamine production and subsequent beige fat activation. Catecholamines 170-183 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 126-132 29025375-2 2017 Hepatocellular carcinoma development is complex because of the metabolism disequilibrium involving SULT1A3/4, a predominant sulfotransferase that metabolizes sulfonic xenobiotics and endogenous catecholamines. Catecholamines 194-208 sulfotransferase family 1A member 3 Homo sapiens 99-106 28931752-3 2017 We here show that l-3,4-dihydroxyphenylalanine (L-DOPA), a precursor of catecholamines, sensitizes the vascular adrenergic receptor alpha1 (ADRA1) through activation of L-DOPA receptor GPR143. Catecholamines 72-86 adrenergic receptor, alpha 1d Mus musculus 140-145 28931752-3 2017 We here show that l-3,4-dihydroxyphenylalanine (L-DOPA), a precursor of catecholamines, sensitizes the vascular adrenergic receptor alpha1 (ADRA1) through activation of L-DOPA receptor GPR143. Catecholamines 72-86 G protein-coupled receptor 143 Mus musculus 185-191 28710773-4 2017 We demonstrated that a proportion of human Th17 cells express beta 2-adrenergic receptor (beta2AR), a G protein-coupled receptor that responds to catecholamines. Catecholamines 146-160 adrenoceptor beta 2 Homo sapiens 62-88 28710773-4 2017 We demonstrated that a proportion of human Th17 cells express beta 2-adrenergic receptor (beta2AR), a G protein-coupled receptor that responds to catecholamines. Catecholamines 146-160 adrenoceptor beta 2 Homo sapiens 90-97 28737969-6 2017 Moreover, immobilization stress elevated the mRNA levels of tyrosine hydroxylase (Th), dopamine beta-hydroxylase (Dbh), and cytochrome P450 side-chain cleavage (P450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland. Catecholamines 192-205 dopamine beta-hydroxylase Rattus norvegicus 87-112 28737969-6 2017 Moreover, immobilization stress elevated the mRNA levels of tyrosine hydroxylase (Th), dopamine beta-hydroxylase (Dbh), and cytochrome P450 side-chain cleavage (P450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland. Catecholamines 192-205 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 161-168 28954489-0 2017 Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients. Catecholamines 74-88 renalase, FAD dependent amine oxidase Homo sapiens 10-18 28807144-4 2017 This current allegedly flow through voltage-gated CaV1.3L-type Ca2+ channels, and is important for controlling vestibular hair cell sensory function and catecholamine secretion, respectively. Catecholamines 153-166 caveolin 1 Rattus norvegicus 50-54 28596236-7 2017 Insulin-stimulated glycogen synthase activity was completely ablated during hyperinsulinemic hypoglycemia, and catecholamine signaling via cAMP-dependent protein kinase and phosphorylation of inhibiting sites on glycogen synthase all increased. Catecholamines 111-124 insulin Homo sapiens 0-7 28667172-1 2017 The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. Catecholamines 76-90 chromogranin A Homo sapiens 40-44 28805732-5 2017 Hormones that activate cAMP signaling, such as catecholamine, have been found to regulate the intracellular trafficking of CFTR. Catecholamines 47-60 CF transmembrane conductance regulator Homo sapiens 123-127 28818208-8 2017 RESULTS: Enhanced beta-adrenergic signaling in TTS-iPSC-CMs under catecholamine-induced stress increased expression of the cardiac stress marker NR4A1; cyclic adenosine monophosphate levels; and cyclic adenosine monophosphate-dependent protein kinase A-mediated hyperphosphorylation of RYR2-S2808, PLN-S16, TNI-S23/24, and Cav1.2-S1928, and leads to a reduced calcium time to transient 50% decay. Catecholamines 66-79 nuclear receptor subfamily 4 group A member 1 Homo sapiens 145-150 28818208-8 2017 RESULTS: Enhanced beta-adrenergic signaling in TTS-iPSC-CMs under catecholamine-induced stress increased expression of the cardiac stress marker NR4A1; cyclic adenosine monophosphate levels; and cyclic adenosine monophosphate-dependent protein kinase A-mediated hyperphosphorylation of RYR2-S2808, PLN-S16, TNI-S23/24, and Cav1.2-S1928, and leads to a reduced calcium time to transient 50% decay. Catecholamines 66-79 ryanodine receptor 2 Homo sapiens 286-290 28818208-8 2017 RESULTS: Enhanced beta-adrenergic signaling in TTS-iPSC-CMs under catecholamine-induced stress increased expression of the cardiac stress marker NR4A1; cyclic adenosine monophosphate levels; and cyclic adenosine monophosphate-dependent protein kinase A-mediated hyperphosphorylation of RYR2-S2808, PLN-S16, TNI-S23/24, and Cav1.2-S1928, and leads to a reduced calcium time to transient 50% decay. Catecholamines 66-79 phospholamban Homo sapiens 298-301 28818208-8 2017 RESULTS: Enhanced beta-adrenergic signaling in TTS-iPSC-CMs under catecholamine-induced stress increased expression of the cardiac stress marker NR4A1; cyclic adenosine monophosphate levels; and cyclic adenosine monophosphate-dependent protein kinase A-mediated hyperphosphorylation of RYR2-S2808, PLN-S16, TNI-S23/24, and Cav1.2-S1928, and leads to a reduced calcium time to transient 50% decay. Catecholamines 66-79 calcium voltage-gated channel subunit alpha1 C Homo sapiens 323-329 28818208-9 2017 These cellular catecholamine-dependent responses were mainly mediated by beta1-adrenoceptor signaling in TTS. Catecholamines 15-28 adrenoceptor beta 1 Homo sapiens 73-91 28613940-4 2017 RESULTS: Glucose intolerance and diabetes mellitus, resulting from high circulating levels of catecholamines, are mainly the product of compromised insulin secretion from the beta-cells in the pancreas, decreased glucose uptake in the peripheral tissues, and increased insulin resistance. Catecholamines 94-108 insulin Homo sapiens 148-155 28613940-4 2017 RESULTS: Glucose intolerance and diabetes mellitus, resulting from high circulating levels of catecholamines, are mainly the product of compromised insulin secretion from the beta-cells in the pancreas, decreased glucose uptake in the peripheral tissues, and increased insulin resistance. Catecholamines 94-108 insulin Homo sapiens 269-276 28531318-4 2017 Using immunohistochemistry, flow cytometry, and reverse transcription-polymerase chain reaction, we show AgRP is present in the mouse adrenal medulla and is expressed by neuroendocrine chromaffin cells that also synthesize the catecholamines and neuropeptide Y. Catecholamines 227-241 agouti related neuropeptide Mus musculus 105-109 28512254-0 2017 Catecholamines facilitate VEGF-dependent angiogenesis via beta2-adrenoceptor-induced Epac1 and PKA activation. Catecholamines 0-14 vascular endothelial growth factor A Homo sapiens 26-30 28194805-0 2017 Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency. Catecholamines 56-70 LOC105613195 Ovis aries 21-28 28194805-3 2017 Low blood oxygen concentrations increase fetal plasma catecholamine concentrations, which lower fetal insulin concentrations. Catecholamines 54-67 LOC105613195 Ovis aries 102-109 28194805-6 2017 Experimental evidence supporting this hypothesis shows that chronic elevation in circulating catecholamines in IUGR fetuses persistently inhibits insulin concentrations and secretion. Catecholamines 93-107 LOC105613195 Ovis aries 146-153 28194805-7 2017 Elevated catecholamines also allow for maintenance of a normal fetal basal metabolic rate despite low fetal insulin and glucose concentrations while suppressing fetal growth. Catecholamines 9-23 LOC105613195 Ovis aries 108-115 28194805-8 2017 Importantly, a compensatory augmentation in insulin secretion occurs following inhibition or cessation of catecholamine signalling in IUGR fetuses. Catecholamines 106-119 LOC105613195 Ovis aries 44-51 27389777-1 2017 Tyrosine hydroxylase (TH), a rate-limiting step in catecholamine synthesis in which its activity influences Alzheimer disease, Parkinson disease, and IQ of schizophrenia patients, has been studied for a long time. Catecholamines 51-64 tyrosine hydroxylase Homo sapiens 0-20 27389777-1 2017 Tyrosine hydroxylase (TH), a rate-limiting step in catecholamine synthesis in which its activity influences Alzheimer disease, Parkinson disease, and IQ of schizophrenia patients, has been studied for a long time. Catecholamines 51-64 tyrosine hydroxylase Homo sapiens 22-24 28437005-2 2017 Herein we show that activation of ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) is necessary for 2-OHE2 - and 4-OHE2 -induced P-UAEC proliferation, as well as proliferation induced by the parent hormone E2 beta and other beta-AR signalling hormones (i.e. catecholamines). Catecholamines 271-285 mitogen-activated protein kinase 3 Homo sapiens 34-40 28437005-2 2017 Herein we show that activation of ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) is necessary for 2-OHE2 - and 4-OHE2 -induced P-UAEC proliferation, as well as proliferation induced by the parent hormone E2 beta and other beta-AR signalling hormones (i.e. catecholamines). Catecholamines 271-285 mitogen-activated protein kinase 8 Homo sapiens 50-53 28683966-6 2017 RESULTS: Here we report that, in vitro, Meto prevents catecholamine-induced down-regulation of S1PR1, a major cardiac protective signaling pathway. Catecholamines 54-67 sphingosine-1-phosphate receptor 1 Homo sapiens 95-100 28683281-3 2017 These findings are unexpected because IL-4 activation of macrophages has been proposed to have a pivotal role in cold-induced thermogenesis by stimulating macrophage catecholamine production to recruit thermogenic beige or brite fat. Catecholamines 166-179 interleukin 4 Homo sapiens 38-42 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. Catecholamines 153-167 catechol-O-methyltransferase Homo sapiens 0-28 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. Catecholamines 153-167 catechol-O-methyltransferase Homo sapiens 30-34 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. Catecholamines 153-167 catechol-O-methyltransferase Homo sapiens 190-194 28700579-3 2017 Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogranin B, which are normally found in neuronal presynaptic terminals storing catecholamines such as dopamine. Catecholamines 171-185 chromogranin B Homo sapiens 88-102 28512254-10 2017 In accordance, beta2AR- and AC-activation, but not Epac1 stimulation increased VEGF secretion in HUVEC.Our data indicate that high levels of catecholamines, which occur during chronic stress, prime the endothelium for angiogenesis through a beta2AR-mediated increase in endothelial VEGFR-2 expression and VEGF secretion. Catecholamines 141-155 adrenoceptor beta 2 Homo sapiens 15-22 28512254-10 2017 In accordance, beta2AR- and AC-activation, but not Epac1 stimulation increased VEGF secretion in HUVEC.Our data indicate that high levels of catecholamines, which occur during chronic stress, prime the endothelium for angiogenesis through a beta2AR-mediated increase in endothelial VEGFR-2 expression and VEGF secretion. Catecholamines 141-155 vascular endothelial growth factor A Homo sapiens 79-83 28512254-10 2017 In accordance, beta2AR- and AC-activation, but not Epac1 stimulation increased VEGF secretion in HUVEC.Our data indicate that high levels of catecholamines, which occur during chronic stress, prime the endothelium for angiogenesis through a beta2AR-mediated increase in endothelial VEGFR-2 expression and VEGF secretion. Catecholamines 141-155 adrenoceptor beta 2 Homo sapiens 241-248 28512254-10 2017 In accordance, beta2AR- and AC-activation, but not Epac1 stimulation increased VEGF secretion in HUVEC.Our data indicate that high levels of catecholamines, which occur during chronic stress, prime the endothelium for angiogenesis through a beta2AR-mediated increase in endothelial VEGFR-2 expression and VEGF secretion. Catecholamines 141-155 kinase insert domain receptor Homo sapiens 282-289 28512254-10 2017 In accordance, beta2AR- and AC-activation, but not Epac1 stimulation increased VEGF secretion in HUVEC.Our data indicate that high levels of catecholamines, which occur during chronic stress, prime the endothelium for angiogenesis through a beta2AR-mediated increase in endothelial VEGFR-2 expression and VEGF secretion. Catecholamines 141-155 vascular endothelial growth factor A Homo sapiens 282-286 28512254-0 2017 Catecholamines facilitate VEGF-dependent angiogenesis via beta2-adrenoceptor-induced Epac1 and PKA activation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 58-76 28512254-0 2017 Catecholamines facilitate VEGF-dependent angiogenesis via beta2-adrenoceptor-induced Epac1 and PKA activation. Catecholamines 0-14 Rap guanine nucleotide exchange factor 3 Homo sapiens 85-90 28498637-1 2017 It has been suggested that beta2-adrenergic receptor (beta2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. Catecholamines 94-108 adrenoceptor beta 2 Homo sapiens 27-52 28268112-3 2017 Varenicline has been associated with adverse cardiovascular (CV) events, including myocardial infarction, which may be caused by activation of the alpha7 nAChR receptor that in turn stimulates parasympathetic output from the brainstem to the heart, release of catecholamines, and has a prothrombotic effect. Catecholamines 260-274 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 154-159 28862601-1 2017 Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism (monoaminbe oxidases A and B (MAO A and MAO B) and catechol-O-methyl transferase (COMT)) and renalase has been carried out in tissues of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Catecholamines 64-77 monoamine oxidase A Rattus norvegicus 119-124 28862601-1 2017 Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism (monoaminbe oxidases A and B (MAO A and MAO B) and catechol-O-methyl transferase (COMT)) and renalase has been carried out in tissues of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Catecholamines 64-77 monoamine oxidase B Rattus norvegicus 129-134 28862601-1 2017 Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism (monoaminbe oxidases A and B (MAO A and MAO B) and catechol-O-methyl transferase (COMT)) and renalase has been carried out in tissues of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Catecholamines 64-77 catechol-O-methyltransferase Rattus norvegicus 140-169 28862601-2 2017 Among investigated tissues the highest level of mRNA of genes encoding key enzymes of catecholamine catabolism (MAO A, MAO B, COMT) was found in the heart of WKY rats. Catecholamines 86-99 monoamine oxidase A Rattus norvegicus 112-117 28862601-2 2017 Among investigated tissues the highest level of mRNA of genes encoding key enzymes of catecholamine catabolism (MAO A, MAO B, COMT) was found in the heart of WKY rats. Catecholamines 86-99 monoamine oxidase B Rattus norvegicus 119-124 28862601-2 2017 Among investigated tissues the highest level of mRNA of genes encoding key enzymes of catecholamine catabolism (MAO A, MAO B, COMT) was found in the heart of WKY rats. Catecholamines 86-99 catechol-O-methyltransferase Rattus norvegicus 126-130 28498637-4 2017 Catecholamines inhibited doxorubicin (DOX)-induced p53 acetylation and transcription-activation activities by inducing the expression of Sirt1. Catecholamines 0-14 sirtuin 1 Homo sapiens 137-142 28498637-6 2017 In addition, we demonstrated that catecholamines induced resistance of cervical cancer cells to chemotherapeutics both in vitro and in vivo and that beta2-AR was overexpressed in cervical cancer tissues. Catecholamines 34-48 adrenoceptor beta 2 Homo sapiens 149-157 28498637-1 2017 It has been suggested that beta2-adrenergic receptor (beta2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. Catecholamines 94-108 adrenoceptor beta 2 Homo sapiens 54-62 28498637-1 2017 It has been suggested that beta2-adrenergic receptor (beta2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. Catecholamines 94-108 tumor protein p53 Homo sapiens 138-141 28498637-3 2017 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Catecholamines 43-57 sirtuin 1 Homo sapiens 88-118 28498637-7 2017 Our data suggest that the p53-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-AR signaling. Catecholamines 127-141 tumor protein p53 Homo sapiens 26-29 28498637-7 2017 Our data suggest that the p53-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-AR signaling. Catecholamines 127-141 sirtuin 1 Homo sapiens 170-175 28498637-7 2017 Our data suggest that the p53-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-AR signaling. Catecholamines 127-141 adrenoceptor beta 2 Homo sapiens 210-218 28498637-3 2017 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Catecholamines 43-57 sirtuin 1 Homo sapiens 120-125 28498637-3 2017 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Catecholamines 43-57 adrenoceptor beta 2 Homo sapiens 146-154 28498637-3 2017 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Catecholamines 43-57 adrenoceptor beta 2 Homo sapiens 199-207 28498637-3 2017 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Catecholamines 43-57 sirtuin 1 Homo sapiens 325-330 28498637-4 2017 Catecholamines inhibited doxorubicin (DOX)-induced p53 acetylation and transcription-activation activities by inducing the expression of Sirt1. Catecholamines 0-14 tumor protein p53 Homo sapiens 51-54 28746172-7 2017 After Bonferroni correction the polymorphism rs4680 (ValMet) in COMT was significantly associated with lower SBP in participants treated with CCBs (P = .009) with an especially strong impact in elderly individuals (age >= 70) alone (Delta = -14.08 mm Hg, P = .0005).These results underline the important role of estrogens and catecholamines in hypertension and the importance of genotype dependent, age-related adjustments of calcium-channel blocker treatment. Catecholamines 329-343 catechol-O-methyltransferase Homo sapiens 64-68 27618227-9 2017 The catecholamine biosynthetic enzyme dopamine-beta-hydroxylase (DbetaH) was increased in FD/O but not FD/E A2 cells. Catecholamines 4-17 dopamine beta-hydroxylase Rattus norvegicus 38-63 28472467-6 2017 In CPT1C-deficient mice, modulation of the main hypothalamic energy sensors (5" adenosine monophosphate-activated protein kinase, Sirtuin 1, and mammalian target of rapamycin) was impaired and plasma catecholamine levels were decreased. Catecholamines 200-213 carnitine palmitoyltransferase 1c Mus musculus 3-8 28629760-9 2017 Activation of the cAMP/Epac/PKCalpha pathway protected the heart against cytokine-induced cardiac dysfunction, suggesting a new role of catecholamine signaling in compensating for cardiac dysfunction in heart failure. Catecholamines 136-149 cathelicidin antimicrobial peptide Mus musculus 18-22 28629760-9 2017 Activation of the cAMP/Epac/PKCalpha pathway protected the heart against cytokine-induced cardiac dysfunction, suggesting a new role of catecholamine signaling in compensating for cardiac dysfunction in heart failure. Catecholamines 136-149 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 23-27 28629760-9 2017 Activation of the cAMP/Epac/PKCalpha pathway protected the heart against cytokine-induced cardiac dysfunction, suggesting a new role of catecholamine signaling in compensating for cardiac dysfunction in heart failure. Catecholamines 136-149 protein kinase C, alpha Mus musculus 28-36 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-105 dopamine beta-hydroxylase Rattus norvegicus 269-272 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-106 dopamine beta-hydroxylase Rattus norvegicus 269-272 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-105 phenylethanolamine-N-methyltransferase Rattus norvegicus 277-281 28759191-4 2017 The aims of this study are to investigate the effects of age on the biosynthetic pathway of catecholamines in adrenal medulla by determining the level of blood glucose and blood catecholamines, the gene and protein expression of biosynthetic catecholamine enzymes (TH, DBH and PNMT) as well as protein kinase substrates that involved in the phosphorylation of TH in 2DG-induced rats. Catecholamines 92-106 phenylethanolamine-N-methyltransferase Rattus norvegicus 277-281 28489379-1 2017 By means of a formal structural hybridization of the antipsychotic drug aripiprazole and the heterocyclic catecholamine surrogates present in the beta2-adrenoceptor agonists procaterol and BI-167107 (4), we designed and synthesized a collection of novel hydroxy-substituted heteroarylpiperazines and heteroarylhomopiperazines with high dopamine D2 receptor (D2R) affinity. Catecholamines 106-119 adrenoceptor beta 2 Homo sapiens 146-164 28654017-2 2017 Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. Catecholamines 198-211 vitrin Mus musculus 14-17 28630892-0 2017 Disruption of the Axonal Trafficking of Tyrosine Hydroxylase mRNA Impairs Catecholamine Biosynthesis in the Axons of Sympathetic Neurons. Catecholamines 74-87 tyrosine hydroxylase Rattus norvegicus 40-60 28630892-1 2017 Tyrosine hydroxylase (TH) is the enzyme that catalyzes the rate-limiting step in the biosynthesis of the catecholamine neurotransmitters. Catecholamines 105-118 tyrosine hydroxylase Rattus norvegicus 0-20 28630892-1 2017 Tyrosine hydroxylase (TH) is the enzyme that catalyzes the rate-limiting step in the biosynthesis of the catecholamine neurotransmitters. Catecholamines 105-118 tyrosine hydroxylase Rattus norvegicus 22-24 28630892-4 2017 In the present study, the hypothesis was tested that local translation of TH plays an important role in the biosynthesis of the catecholamine neurotransmitters in the axon and/or presynaptic nerve terminal. Catecholamines 128-141 tyrosine hydroxylase Rattus norvegicus 74-76 28630892-9 2017 Taken together, these results provide direct evidence to support the hypothesis that TH mRNA trafficking and local synthesis of TH play an important role in the synthesis of catecholamines in the axon and presynaptic terminal. Catecholamines 174-188 tyrosine hydroxylase Rattus norvegicus 85-87 28630892-9 2017 Taken together, these results provide direct evidence to support the hypothesis that TH mRNA trafficking and local synthesis of TH play an important role in the synthesis of catecholamines in the axon and presynaptic terminal. Catecholamines 174-188 tyrosine hydroxylase Rattus norvegicus 128-130 28452825-3 2017 Val-allele carriers of a common polymorphism of the COMT gene (Val158Met, rs4680) have rapid removal of catecholamines in the prefrontal cortex, limbic system, and reward centers. Catecholamines 104-118 catechol-O-methyltransferase Homo sapiens 52-56 28660243-4 2017 In mice, most AVPV/PeN Kiss1 cells coexpress tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis (in this case, dopamine). Catecholamines 100-113 KiSS-1 metastasis-suppressor Mus musculus 23-28 28660243-4 2017 In mice, most AVPV/PeN Kiss1 cells coexpress tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis (in this case, dopamine). Catecholamines 100-113 tyrosine hydroxylase Mus musculus 45-65 28660243-4 2017 In mice, most AVPV/PeN Kiss1 cells coexpress tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis (in this case, dopamine). Catecholamines 100-113 tyrosine hydroxylase Mus musculus 67-69 28397784-1 2017 Catestatin was discovered as a potent inhibitor of catecholamine secretion and plays important roles in the cardiovascular system. Catecholamines 51-64 chromogranin A Homo sapiens 0-10 28429453-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O-methylation. Catecholamines 85-99 catechol-O-methyltransferase Mus musculus 0-28 28429453-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O-methylation. Catecholamines 85-99 catechol-O-methyltransferase Mus musculus 30-34 27939670-1 2017 Catechol-O-methyltransferase (COMT) is involved in the methylation and inactivation of endogenous and xenobiotic catechol compounds, and serves as a common biochemical link in the catecholamine and catecholestrogen metabolism. Catecholamines 180-193 catechol-O-methyltransferase Homo sapiens 30-34 28485732-6 2017 We then selected one candidate gene for further study, Pdxdc1 (pyridoxal-dependent decarboxylase domain containing 1), because it is a putative enzyme that could metabolize catecholamine neurotransmitters, and thus might be a feasible target for new medications. Catecholamines 173-186 pyridoxal-dependent decarboxylase domain containing 1 Mus musculus 55-61 28485732-6 2017 We then selected one candidate gene for further study, Pdxdc1 (pyridoxal-dependent decarboxylase domain containing 1), because it is a putative enzyme that could metabolize catecholamine neurotransmitters, and thus might be a feasible target for new medications. Catecholamines 173-186 pyridoxal-dependent decarboxylase domain containing 1 Mus musculus 63-116 28356269-0 2017 miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla. Catecholamines 60-74 microRNA 375 Rattus norvegicus 0-7 28356269-1 2017 The adrenal gland is an important endocrine gland in balancing homeostasis and the response to stress by synthesizing and secreting catecholamines (CATs), and it has been confirmed that microRNA-375 (miR-375) is highly expressed in adrenal medulla. Catecholamines 132-146 microRNA 375 Rattus norvegicus 200-207 28212885-2 2017 Here, we report that although catecholamines, mediators of systemic sympathetic activity, display only weak immunosuppressive impact on their own, their combination with inflammatory signals leads to the induction of COX-2 and multiple COX-2-dependent suppressive factors in human myeloid cells and cancer tissues. Catecholamines 30-44 mitochondrially encoded cytochrome c oxidase II Homo sapiens 217-222 28212885-2 2017 Here, we report that although catecholamines, mediators of systemic sympathetic activity, display only weak immunosuppressive impact on their own, their combination with inflammatory signals leads to the induction of COX-2 and multiple COX-2-dependent suppressive factors in human myeloid cells and cancer tissues. Catecholamines 30-44 mitochondrially encoded cytochrome c oxidase II Homo sapiens 236-241 28212885-7 2017 The current demonstration of the interplay between inflammation and the induction of immunosuppressive factors by catecholamines suggest a contextual impact of stress, helping to explain variable results of epidemiologic studies of the link between sympathetic activity and cancer progression, and implicating COX-2 blockade as a potential means to mitigate stress-related immune suppression. Catecholamines 114-128 mitochondrially encoded cytochrome c oxidase II Homo sapiens 310-315 28008098-0 2017 B-type natriuretic peptide increases cortisol and catecholamine concentrations in healthy subjects. Catecholamines 50-63 natriuretic peptide B Homo sapiens 0-26 28414329-4 2017 Recent studies have reported that alternative activation of macrophages in response to interleukin (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway, and that this activation provides an alternative source of locally produced catecholamines during the thermogenic process. Catecholamines 191-204 tyrosine hydroxylase Mus musculus 144-164 28414329-4 2017 Recent studies have reported that alternative activation of macrophages in response to interleukin (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway, and that this activation provides an alternative source of locally produced catecholamines during the thermogenic process. Catecholamines 191-204 tyrosine hydroxylase Mus musculus 166-168 28414329-4 2017 Recent studies have reported that alternative activation of macrophages in response to interleukin (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway, and that this activation provides an alternative source of locally produced catecholamines during the thermogenic process. Catecholamines 300-314 tyrosine hydroxylase Mus musculus 144-164 28414329-4 2017 Recent studies have reported that alternative activation of macrophages in response to interleukin (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catecholamine synthesis pathway, and that this activation provides an alternative source of locally produced catecholamines during the thermogenic process. Catecholamines 300-314 tyrosine hydroxylase Mus musculus 166-168 28609288-0 2017 Eff ect of a single asenapine treatment on Fos expression in the brain catecholamine-synthesizing neurons: impact of a chronic mild stress preconditioning. Catecholamines 71-84 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 43-46 28288049-0 2017 Catecholamine-Induced Chest Pain Mimicking Infarction Due to an MIBG-Negative and DOPA-Positive Succinate Dehydrogenase Syndrome Subunit B-Related Pheochromocytoma. Catecholamines 0-13 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 96-138 28580075-4 2017 Low doses of AVP and its synthetic analog terlipressin can restore vasomotor tone in conditions that are resistant to catecholamines, with preservation of renal blood flow and urine output. Catecholamines 118-132 arginine vasopressin Homo sapiens 13-16 28522796-2 2017 We wanted to elucidate whether beta1-adrenoceptor-polymorphisms affects the postoperative catecholamine consumption and the length of intermediate care unit stay in patients undergoing cardiac surgery, and whether this might be enhanced or attenuated by catechol-O-methyl-transferase (COMT) polymorphism. Catecholamines 90-103 adrenoceptor beta 1 Homo sapiens 31-49 28406285-9 2017 Recent evidence demonstrated that 5-HT1A receptors inhibit catecholamine secretion from adrenal chromaffin cells via an atypical mechanism that does not involve modulation of cellular excitability or voltage-gated Ca2+ channels. Catecholamines 59-72 5-hydroxytryptamine receptor 1A Homo sapiens 34-40 28406285-11 2017 As a framework for future investigation, a model is proposed in which stress-evoked adrenal catecholamine secretion is fine-tuned by SERT-modulated autocrine 5-HT signaling. Catecholamines 92-105 solute carrier family 6 member 4 Homo sapiens 133-137 27879559-3 2017 Angiotensin II (Ang II), a key product of the renin-angiotensin-aldosterone system, is a vasopressor agent that could be used in conjunction with other vasopressors to stabilize critically ill patients during refractory septic shock, and reduce catecholamine requirements. Catecholamines 245-258 angiotensinogen Homo sapiens 0-14 27879559-3 2017 Angiotensin II (Ang II), a key product of the renin-angiotensin-aldosterone system, is a vasopressor agent that could be used in conjunction with other vasopressors to stabilize critically ill patients during refractory septic shock, and reduce catecholamine requirements. Catecholamines 245-258 angiotensinogen Homo sapiens 16-22 28462171-3 2017 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. Catecholamines 91-105 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 22-27 28487631-2 2017 Earlier reports indicate that somatostatin-28 injected intracerebroventricularly counteracts the acute stress-induced ACTH and catecholamine release. Catecholamines 127-140 somatostatin Homo sapiens 30-45 28372594-1 2017 BACKGROUND: Human renalase (RNLS), a recently identified flavoprotein with oxidoreductase activity, is secreted into blood by kidneys and metabolizes circulating catecholamines. Catecholamines 162-176 renalase, FAD dependent amine oxidase Homo sapiens 18-26 28372594-1 2017 BACKGROUND: Human renalase (RNLS), a recently identified flavoprotein with oxidoreductase activity, is secreted into blood by kidneys and metabolizes circulating catecholamines. Catecholamines 162-176 renalase, FAD dependent amine oxidase Homo sapiens 28-32 28372594-1 2017 BACKGROUND: Human renalase (RNLS), a recently identified flavoprotein with oxidoreductase activity, is secreted into blood by kidneys and metabolizes circulating catecholamines. Catecholamines 162-176 thioredoxin reductase 1 Homo sapiens 75-89 28428261-6 2017 Loss of DPF3 in brown adipocytes reduced chromatin accessibility at EBF2-bound enhancers and led to a decrease in basal and catecholamine-stimulated expression of brown fat-selective genes. Catecholamines 124-137 double PHD fingers 3 Homo sapiens 8-12 27780702-2 2017 Catechol-O-methyltransferase, an enzyme that metabolizes catecholamines, is a neuromodulator that is involved with perception and sensitivity to pain. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 0-28 27780702-5 2017 OBJECTIVE: The methionine-containing catechol-O-methyltransferase protein coded by the L allele results in elevated catecholamine levels, reduced inactivation of the dopaminergic and adrenergic systems, and increased sensitivity to pain. Catecholamines 116-129 catechol-O-methyltransferase Homo sapiens 37-65 27982456-6 2017 This regulatory pathway may be physiologically relevant in situations of prolonged stressful conflicts where a sustained catecholamine release is regulated by mitochondrial Ca2+ circulation through the mNCX, which couples respiration and ATP synthesis to long-term stimulation of chromaffin cells by endogenously released ACh. Catecholamines 121-134 T cell leukemia, homeobox 2 Mus musculus 202-206 28214967-14 2017 Even without major clinical consequences in cardiac function, these alterations were followed by a significant increase in gene expression of beta1 and beta2 receptors and GRK-2, suggesting that this is one of the mechanisms responsible for the exacerbated response of cardiomyocytes to circulating catecholamines. Catecholamines 299-313 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 142-147 28214967-14 2017 Even without major clinical consequences in cardiac function, these alterations were followed by a significant increase in gene expression of beta1 and beta2 receptors and GRK-2, suggesting that this is one of the mechanisms responsible for the exacerbated response of cardiomyocytes to circulating catecholamines. Catecholamines 299-313 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 152-157 28214967-14 2017 Even without major clinical consequences in cardiac function, these alterations were followed by a significant increase in gene expression of beta1 and beta2 receptors and GRK-2, suggesting that this is one of the mechanisms responsible for the exacerbated response of cardiomyocytes to circulating catecholamines. Catecholamines 299-313 G protein-coupled receptor kinase 2 Homo sapiens 172-177 28214967-16 2017 Although other factors may be involved, this study confirms that CPB acts as a potent inducer of increased gene expression of beta- adrenergic receptors and GRK-2, making the myocardium of these infants more susceptible to the effects of circulating endogenous catecholamines, which may contribute to the development of irreversible myocardial damage and death. Catecholamines 261-275 G protein-coupled receptor kinase 2 Homo sapiens 157-162 28302297-0 2017 GRK2 Regulates alpha2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells. Catecholamines 52-65 G protein-coupled receptor kinase 2 Homo sapiens 0-4 28303919-6 2017 Mechanistic studies demonstrated that adiponectin and nitric oxide are released after activation of adipocyte-expressed beta3 adrenoceptors by catecholamines, and identified eosinophils as a novel source of these mediators. Catecholamines 143-157 adiponectin, C1Q and collagen domain containing Mus musculus 38-49 28011264-3 2017 We investigated the effects of 20-min moderate (65-70% VO2 peak) exercise-induced catecholamine production on LPS-stimulated TNF production by monocytes in 47 healthy volunteers and determined AR subtypes involved. Catecholamines 82-95 tumor necrosis factor Homo sapiens 125-128 28282374-0 2017 Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter. Catecholamines 21-34 solute carrier family 6 member 2 Rattus norvegicus 108-134 27979980-1 2017 Interleukin-6 (IL-6) is released from skeletal muscle cells and induced by exercise, heat, catecholamine, glucose, lipopolysaccharide, reactive oxygen species, and inflammation. Catecholamines 91-104 interleukin 6 Mus musculus 0-13 28028077-1 2017 In pancreatic beta-cells, pharmacological concentrations of catecholamines, including adrenaline, have been used to inhibit insulin release and explore the multiple mechanisms involved. Catecholamines 60-74 insulin Homo sapiens 124-131 28049082-1 2017 Catechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 0-28 28049082-1 2017 Catechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 30-34 28049082-1 2017 Catechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 258-262 28103426-7 2017 Both substances were catecholamine selective with IC50 values of 8,805 nM and >10,000 nM for (+-)-threo-4F-MPH and MPH at the serotonin transporter. Catecholamines 21-34 solute carrier family 6 member 4 Homo sapiens 129-150 27979980-1 2017 Interleukin-6 (IL-6) is released from skeletal muscle cells and induced by exercise, heat, catecholamine, glucose, lipopolysaccharide, reactive oxygen species, and inflammation. Catecholamines 91-104 interleukin 6 Mus musculus 15-19 28228748-5 2017 CgA knockout mice (Chga-KO) display: (i) hypertension with increased plasma catecholamines, (ii) obesity, (iii) improved hepatic insulin sensitivity, and (iv) muscle insulin resistance. Catecholamines 76-90 chromogranin A Mus musculus 0-3 28074314-2 2017 beta-adrenergic receptors (beta-AR) are targets of endogenous catecholamines such as epinephrine that have gained importance in the context of cancer biology. Catecholamines 62-76 adrenoceptor beta 2 Homo sapiens 27-34 28074314-12 2017 This study highlights that catecholamines, through beta-AR activation, seem to be involved in mammary gland development, inducing mature duct formation. Catecholamines 27-41 adrenoceptor beta 2 Homo sapiens 51-58 28181498-0 2017 Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Catecholamines 43-56 angiotensin II receptor type 1 Homo sapiens 16-20 28181498-0 2017 Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Catecholamines 43-56 transient receptor potential cation channel subfamily C member 3 Homo sapiens 75-80 28181498-3 2017 Here we reveal that TRV120027, a beta-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), stimulates acute catecholamine secretion through coupling with the transient receptor potential cation channel subfamily C 3 (TRPC3). Catecholamines 127-140 arrestin beta 1 Homo sapiens 33-48 28181498-3 2017 Here we reveal that TRV120027, a beta-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), stimulates acute catecholamine secretion through coupling with the transient receptor potential cation channel subfamily C 3 (TRPC3). Catecholamines 127-140 angiotensin II receptor type 1 Homo sapiens 71-101 28181498-3 2017 Here we reveal that TRV120027, a beta-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), stimulates acute catecholamine secretion through coupling with the transient receptor potential cation channel subfamily C 3 (TRPC3). Catecholamines 127-140 angiotensin II receptor type 1 Homo sapiens 103-107 27890888-1 2017 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of endogenous catechol amines and estrogens and exogenous catechol-type of drugs. Catecholamines 78-93 catechol O-methyltransferase Callithrix jacchus 0-28 27890888-1 2017 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of endogenous catechol amines and estrogens and exogenous catechol-type of drugs. Catecholamines 78-93 catechol O-methyltransferase Callithrix jacchus 30-34 27863349-9 2017 Moreover, TRPV1 channel inhibition reduces massive catecholamine release, improves survival during hemorrhage. Catecholamines 51-64 transient receptor potential cation channel subfamily V member 1 Homo sapiens 10-15 28625321-1 2017 OBJECTIVES: Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 12-40 28625321-1 2017 OBJECTIVES: Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 42-46 28061374-7 2017 RESULTS: Elevated catecholamine metabolites, especially 3MT, correlated with nine out of 12 NBL characteristics such as stage, age, MYCN amplification, loss of heterozygosity for 1p and bone-marrow invasion. Catecholamines 18-31 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 132-136 28144392-0 2017 Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort. Catecholamines 58-71 arginine vasopressin Homo sapiens 0-11 27939824-10 2017 (i) Catecholamines may stimulate macrophages and release complement C5 via alpha2-receptors. Catecholamines 4-18 hemolytic complement Mus musculus 57-70 28082361-1 2017 Various ryanodine receptor 2 (RyR2) point mutations cause catecholamine-induced polymorphic ventricular tachycardia (CPVT), a life-threatening arrhythmia evoked by diastolic intracellular Ca2+ release dysfunction. Catecholamines 58-71 ryanodine receptor 2 Homo sapiens 8-28 28082361-1 2017 Various ryanodine receptor 2 (RyR2) point mutations cause catecholamine-induced polymorphic ventricular tachycardia (CPVT), a life-threatening arrhythmia evoked by diastolic intracellular Ca2+ release dysfunction. Catecholamines 58-71 ryanodine receptor 2 Homo sapiens 30-34 27989747-8 2017 Our results demonstrate that chronic MAO inhibition by TCP primarily affects 5-HT concentrations, but also raises central catecholamine levels. Catecholamines 122-135 monoamine oxidase A Rattus norvegicus 37-40 28144392-1 2017 AIM: To examine patient-centered outcomes with vasopressin (AVP) use in patients with cirrhosis with catecholamine-refractory septic shock. Catecholamines 101-114 arginine vasopressin Homo sapiens 47-58 29275472-1 2017 In the last 10-15 years, there has been a recognition that the catecholamines (norepinephrine, NE, and epinephrine, Epi) released by the sympathetic nervous system under stressful conditions promote tumor growth through a variety of mechanisms. Catecholamines 63-77 exocrine pancreatic insufficiency Mus musculus 116-119 28405891-1 2017 Studies suggest that renalase, a renal catecholamine-inactivating enzyme, plays a major role in the pathogenesis of kidney and cardiovascular diseases in adults. Catecholamines 39-52 renalase, FAD dependent amine oxidase Homo sapiens 21-29 28076805-10 2017 In addition, we showed that incubation of normal RBCs and SS-RBCs with epinephrine, a catecholamine that binds to the beta-adrenergic receptor and activates the cAMP-PKA-dependent pathway, caused a significant increase in the frequency of active ICAM-4 receptors in both normal RBCs and SS-RBCs. Catecholamines 86-99 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Homo sapiens 246-252 31406740-8 2017 The oxytocinergic system regulates the release of oxytocin, which is an effect that is opposite that which occurs with the human stress response, in which the sympathetic nervous system is activated to release catecholamines in response to harmful or threatening stimuli. Catecholamines 210-224 oxytocin/neurophysin I prepropeptide Homo sapiens 4-12 31406740-10 2017 During kangaroo care, oxytocin blocks the stress response and decreases the circulation of catecholamines, yielding positive outcomes that include maternal stress reduction and prevention of postpartum depression. Catecholamines 91-105 oxytocin/neurophysin I prepropeptide Homo sapiens 22-30 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-68 catechol-O-methyltransferase Homo sapiens 6-34 28618990-4 2017 RESULTS: CST is mainly known as an inhibitor of the nicotinic-dependent Catecholamine (CA) release, and an anti-hypertensive peptide, but its role includes a modulation of antioxidant and immune defense, epidermal function, and adipose tissue homeostasis. Catecholamines 72-85 cystatin 12, pseudogene Homo sapiens 9-12 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-68 catechol-O-methyltransferase Homo sapiens 36-40 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-67 catechol-O-methyltransferase Homo sapiens 6-34 27987399-2 2017 Since catechol-O-methyltransferase (COMT) metabolizes catecholamines and mediates adrenergic, noradrenergic, and dopaminergic signaling responses, we investigated the effects of the COMT polymorphisms rs4633 and rs4680 on cerebrospinal fluid (CSF) catecholamine concentrations in autopsies of subjects who died of drug intoxication. Catecholamines 54-67 catechol-O-methyltransferase Homo sapiens 36-40 27147232-1 2017 Aromatic L-amino acid decarboxylase (AADC) deficiency is an autosomal recessive inborn error of metabolism, affecting catecholamines and serotonin biosynthesis. Catecholamines 118-132 dopa decarboxylase Homo sapiens 0-35 28011710-2 2017 We conducted a genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptide derived from chromogranin A (CHGA), and other CHGA- or chromogranin B (CHGB)-related peptides, in 545 US and 1252 Australian subjects. Catecholamines 72-85 chromogranin A Homo sapiens 126-140 28011710-5 2017 In chromaffin cells, CHGA and KLKB1 proteins co-localized in catecholamine storage granules. Catecholamines 61-74 chromogranin A Homo sapiens 21-25 28011710-5 2017 In chromaffin cells, CHGA and KLKB1 proteins co-localized in catecholamine storage granules. Catecholamines 61-74 kallikrein B1 Homo sapiens 30-35 27222484-4 2017 In addition, chronic overexpression of GRK2 inhibits catecholamine induction of vital positive chronotropic and ionotropic effects required to preserve cardiac output leading to worsening of congestive HF. Catecholamines 53-66 G protein-coupled receptor kinase 2 Homo sapiens 39-43 27267863-5 2017 The MT1 receptor, but not the MT2 receptor, was expressed in PC12 cells, and luzindole treatment reversed the inhibitory effect of melatonin on Th expression, suggesting that MT1 is a functional receptor for the control of catecholamine synthesis. Catecholamines 223-236 metallothionein 1 Rattus norvegicus 4-7 27267863-5 2017 The MT1 receptor, but not the MT2 receptor, was expressed in PC12 cells, and luzindole treatment reversed the inhibitory effect of melatonin on Th expression, suggesting that MT1 is a functional receptor for the control of catecholamine synthesis. Catecholamines 223-236 metallothionein 1 Rattus norvegicus 175-178 27267863-10 2017 Collectively, the results indicate that melatonin plays a modulatory role in catecholamine synthesis by cooperating with BMP-4 and glucocorticoid in the adrenal medulla. Catecholamines 77-90 bone morphogenetic protein 4 Rattus norvegicus 121-126 27147232-1 2017 Aromatic L-amino acid decarboxylase (AADC) deficiency is an autosomal recessive inborn error of metabolism, affecting catecholamines and serotonin biosynthesis. Catecholamines 118-132 dopa decarboxylase Homo sapiens 37-41 28160962-1 2017 BACKGROUND: Renalase, with possible monoamine oxidase activity, is implicated in degradation of catecholamines; which suggests novel mechanisms of cardiovascular complications in patients with chronic kidney diseases. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 12-20 27659492-8 2017 The bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids microinjected into the PVN of anaesthetized rats depend on stimulatory glutamatergic and inhibitory GABAergic inputs to the sympathetic tone; the glutamatergic input is related to AT1, TP and beta2-adrenergic receptors and catecholamine release from the adrenal medulla whereas the GABAergic input is reinforced by NO. Catecholamines 303-316 cannabinoid receptor 1 Rattus norvegicus 19-22 28100850-2 2016 Apart from catecholamines, DDC catalyses the biosynthesis of serotonin and trace amines. Catecholamines 11-25 dopa decarboxylase Homo sapiens 27-30 28456872-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 0-28 28456872-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 30-34 28004763-1 2016 Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine neurotransmitters and hormones, binds to negatively charged phospholipid membranes. Catecholamines 70-83 tyrosine hydroxylase Rattus norvegicus 0-20 28066248-2 2016 One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 195-209 catechol-O-methyltransferase Rattus norvegicus 68-96 28066248-2 2016 One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 195-209 catechol-O-methyltransferase Rattus norvegicus 98-102 28066248-13 2016 Importantly, this sensitive assay was able to detect the presence of COMT activity in extracellular vesicles secreted by hepatocytes supporting a potential role of these vesicles in catecholamines and catecholestrogens metabolisms. Catecholamines 182-196 catechol-O-methyltransferase Rattus norvegicus 69-73 28004763-1 2016 Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine neurotransmitters and hormones, binds to negatively charged phospholipid membranes. Catecholamines 70-83 tyrosine hydroxylase Rattus norvegicus 22-24 27922125-8 2016 The increase in both sympathetic tone and responsiveness of adipocytes to catecholamines reveals a novel role for ERbeta in controlling browning of adipose tissue. Catecholamines 74-88 estrogen receptor 2 (beta) Mus musculus 114-120 27769893-1 2016 Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata. Catecholamines 34-47 phenylethanolamine-N-methyltransferase Rattus norvegicus 69-107 27769893-1 2016 Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata. Catecholamines 34-47 phenylethanolamine-N-methyltransferase Rattus norvegicus 109-113 28275384-2 2016 Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Catecholamines 70-83 tyrosine hydroxylase Homo sapiens 0-20 28235174-5 2016 Authors of the reviewed studies suggested that the morning dose of the ACE inhibitor be held, and those patients experienced decreased catecholamine use postoperatively and shorter duration of decreased mean arterial pressure. Catecholamines 135-148 angiotensin I converting enzyme Homo sapiens 71-74 27619075-4 2016 COMT is a critical enzyme in the degradation of catecholamine neurotransmitters in the brain. Catecholamines 48-61 catechol-O-methyltransferase Homo sapiens 0-4 28275384-2 2016 Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Catecholamines 70-83 tyrosine hydroxylase Homo sapiens 22-24 28275384-2 2016 Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Catecholamines 70-83 tyrosine hydroxylase Homo sapiens 136-138 27444150-1 2016 Tyrosine hydroxylase (TH), a rate-limiting enzyme for the synthesis of catecholamines, is expressed in T lymphocytes. Catecholamines 71-85 tyrosine hydroxylase Mus musculus 0-20 27444150-1 2016 Tyrosine hydroxylase (TH), a rate-limiting enzyme for the synthesis of catecholamines, is expressed in T lymphocytes. Catecholamines 71-85 tyrosine hydroxylase Mus musculus 22-24 27770433-1 2016 The pro-inflammatory cytokines, tumor necrosis factor-alpha, and interleukin-1beta/alpha modulate catecholamine secretion, and long-term gene regulation, in chromaffin cells of the adrenal medulla. Catecholamines 98-111 interleukin 1 beta Bos taurus 65-82 27754851-8 2016 We identified the juvenile hormone as a mediator of FOXO regulation of catecholamine metabolism. Catecholamines 71-84 forkhead box, sub-group O Drosophila melanogaster 52-56 28195064-2 2016 It is already known that adrenergic sensitization of TRPV1 receptors or catecholamine-induced TRPV1 upregulation are involved in increased excitability and pain via mainly alpha1 adrenergic receptors, but it is not known if reduced TRPV1 desensitization is involved in this process, as well. Catecholamines 72-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 28195064-2 2016 It is already known that adrenergic sensitization of TRPV1 receptors or catecholamine-induced TRPV1 upregulation are involved in increased excitability and pain via mainly alpha1 adrenergic receptors, but it is not known if reduced TRPV1 desensitization is involved in this process, as well. Catecholamines 72-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 28195064-2 2016 It is already known that adrenergic sensitization of TRPV1 receptors or catecholamine-induced TRPV1 upregulation are involved in increased excitability and pain via mainly alpha1 adrenergic receptors, but it is not known if reduced TRPV1 desensitization is involved in this process, as well. Catecholamines 72-85 adrenoceptor alpha 1D Homo sapiens 172-178 28195064-2 2016 It is already known that adrenergic sensitization of TRPV1 receptors or catecholamine-induced TRPV1 upregulation are involved in increased excitability and pain via mainly alpha1 adrenergic receptors, but it is not known if reduced TRPV1 desensitization is involved in this process, as well. Catecholamines 72-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 28195064-5 2016 The results showed that both catecholamines produced significant reduction of TRPV1 desensitization, which was mediated by alpha1, alpha2 and beta2 receptors. Catecholamines 29-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 78-83 28195064-5 2016 The results showed that both catecholamines produced significant reduction of TRPV1 desensitization, which was mediated by alpha1, alpha2 and beta2 receptors. Catecholamines 29-43 adrenoceptor alpha 1D Homo sapiens 123-129 28195064-5 2016 The results showed that both catecholamines produced significant reduction of TRPV1 desensitization, which was mediated by alpha1, alpha2 and beta2 receptors. Catecholamines 29-43 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 142-147 27534875-0 2016 Dorsomedial hypothalamic NPY affects cholecystokinin-induced satiety via modulation of brain stem catecholamine neuronal signaling. Catecholamines 98-111 neuropeptide Y Rattus norvegicus 25-28 27621315-8 2016 In addition, M2 macrophage activation also contributed to the beiging effects of ADM2 through catecholamine secretion. Catecholamines 94-107 adrenomedullin 2 Mus musculus 81-85 27534875-0 2016 Dorsomedial hypothalamic NPY affects cholecystokinin-induced satiety via modulation of brain stem catecholamine neuronal signaling. Catecholamines 98-111 cholecystokinin Rattus norvegicus 37-52 27664956-16 2016 The surging catecholamines may activate ADRB2 and CREB, yielding increased angiogenesis and cellular proliferation in ectopic endometrium in mice with induced endometriosis. Catecholamines 12-26 adrenergic receptor, beta 2 Mus musculus 40-45 27591224-10 2016 Moreover, TNF, via both TNFR1 and TNFR2, channeled an alternate CSC neuroadrenergic-like fate (capable of catecholamine synthesis) during differentiation. Catecholamines 106-119 tumor necrosis factor Mus musculus 10-13 27591224-10 2016 Moreover, TNF, via both TNFR1 and TNFR2, channeled an alternate CSC neuroadrenergic-like fate (capable of catecholamine synthesis) during differentiation. Catecholamines 106-119 tumor necrosis factor receptor superfamily, member 1a Mus musculus 24-29 27591224-10 2016 Moreover, TNF, via both TNFR1 and TNFR2, channeled an alternate CSC neuroadrenergic-like fate (capable of catecholamine synthesis) during differentiation. Catecholamines 106-119 tumor necrosis factor receptor superfamily, member 1a Mus musculus 34-39 27554468-0 2016 White Adipocyte Adiponectin Exocytosis Is Stimulated via beta3-Adrenergic Signaling and Activation of Epac1: Catecholamine Resistance in Obesity and Type 2 Diabetes. Catecholamines 109-122 adiponectin, C1Q and collagen domain containing Mus musculus 16-27 27554468-0 2016 White Adipocyte Adiponectin Exocytosis Is Stimulated via beta3-Adrenergic Signaling and Activation of Epac1: Catecholamine Resistance in Obesity and Type 2 Diabetes. Catecholamines 109-122 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 102-107 27554468-7 2016 Small interfering RNA-mediated knockdown of beta3AR (~60%) and Epac1 (~50%) was associated with abrogated catecholamine-stimulated adiponectin secretion. Catecholamines 106-119 adrenergic receptor, beta 3 Mus musculus 44-51 27554468-7 2016 Small interfering RNA-mediated knockdown of beta3AR (~60%) and Epac1 (~50%) was associated with abrogated catecholamine-stimulated adiponectin secretion. Catecholamines 106-119 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 63-68 27554468-7 2016 Small interfering RNA-mediated knockdown of beta3AR (~60%) and Epac1 (~50%) was associated with abrogated catecholamine-stimulated adiponectin secretion. Catecholamines 106-119 adiponectin, C1Q and collagen domain containing Mus musculus 131-142 27554468-9 2016 We further suggest that adrenergically stimulated adiponectin secretion is disturbed in obesity/type 2 diabetes as a result of the reduced expression of beta3ARs and Epac1 in a state we define as "catecholamine resistance." Catecholamines 197-210 adiponectin, C1Q and collagen domain containing Mus musculus 50-61 27554468-9 2016 We further suggest that adrenergically stimulated adiponectin secretion is disturbed in obesity/type 2 diabetes as a result of the reduced expression of beta3ARs and Epac1 in a state we define as "catecholamine resistance." Catecholamines 197-210 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 166-171 27664956-16 2016 The surging catecholamines may activate ADRB2 and CREB, yielding increased angiogenesis and cellular proliferation in ectopic endometrium in mice with induced endometriosis. Catecholamines 12-26 cAMP responsive element binding protein 1 Mus musculus 50-54 27133786-6 2016 Under chronic unpredictable stress, the adrenergic nervous system was markedly activated, as the expression of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, in bone marrow and colonic epithelium was enhanced, especially in the myenteric ganglia. Catecholamines 161-174 tyrosine hydroxylase Homo sapiens 111-131 27491309-1 2016 Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline. Catecholamines 226-240 tyrosine hydroxylase Homo sapiens 0-20 27491309-1 2016 Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline. Catecholamines 226-240 tyrosine hydroxylase Homo sapiens 22-24 27788216-2 2016 Arginine vasopressin (AVP) and analogs with V1A receptor agonist activity are increasingly used to treat fluid-resistant vasodilatory hypotension, including catecholamine-refractory septic shock. Catecholamines 157-170 vasopressin-neurophysin 2-copeptin Oryctolagus cuniculus 0-20 26626970-8 2016 The tyrosinase enzyme functionalized NiO platform has good bio-sensing efficacy and can be used in detection of other catecholamines and phenolic neurochemicals. Catecholamines 118-132 tyrosinase Homo sapiens 4-14 27667649-7 2016 NHSG ZrO2-PPO sorbent provided excellent microextraction performance for catecholamines, low detection limits (5.6-9.6pM), high run-to-run reproducibility (RSD 0.6-5.1%), high desorption efficiency (95.0-99.5%) and high enrichment factors (~1480-2650) for dopamine and epinephrine, respectively, extracted from synthetic urine samples. Catecholamines 73-87 protoporphyrinogen oxidase Homo sapiens 10-13 27822026-3 2016 Renalase, secreted by the kidney and circulated in blood, may regulate the sympathetic tone by catecholamine degradation and in this way has an impact on cardiovascular and renal complications. Catecholamines 95-108 renalase, FAD dependent amine oxidase Homo sapiens 0-8 27385593-2 2016 Beta-2 adrenoreceptor (ADRB2) is a functional G-coupled protein expressed in the vascular endothelium of lungs, alveolar walls, and the ganglions of cholinergic nerves which induces bronchodilation in response to catecholamines. Catecholamines 213-227 adrenoceptor beta 2 Homo sapiens 0-21 27689101-6 2016 To achieve this goal we have evaluated in vivo three partial sequences of the promoter for human tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis. Catecholamines 147-160 tyrosine hydroxylase Homo sapiens 97-117 27562191-6 2016 Furthermore, administration of IL-33 markedly increases the fraction of ILC2 and eosinophil as well as the expression of UCP1 and tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, in adipose tissue of HFD-fed mice. Catecholamines 183-196 interleukin 33 Mus musculus 31-36 27562191-6 2016 Furthermore, administration of IL-33 markedly increases the fraction of ILC2 and eosinophil as well as the expression of UCP1 and tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, in adipose tissue of HFD-fed mice. Catecholamines 183-196 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 121-125 27562191-6 2016 Furthermore, administration of IL-33 markedly increases the fraction of ILC2 and eosinophil as well as the expression of UCP1 and tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, in adipose tissue of HFD-fed mice. Catecholamines 183-196 tyrosine hydroxylase Mus musculus 130-150 27562191-6 2016 Furthermore, administration of IL-33 markedly increases the fraction of ILC2 and eosinophil as well as the expression of UCP1 and tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, in adipose tissue of HFD-fed mice. Catecholamines 183-196 tyrosine hydroxylase Mus musculus 152-154 27457818-2 2016 Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 9-37 27457818-2 2016 Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 39-43 27548835-4 2016 Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system. Catecholamines 227-241 catechol-O-methyltransferase Homo sapiens 39-67 27548835-4 2016 Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system. Catecholamines 227-241 catechol-O-methyltransferase Homo sapiens 69-73 27548835-4 2016 Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system. Catecholamines 227-241 catechol-O-methyltransferase Homo sapiens 135-139 27681312-6 2016 Finally, we found that FoxO1 directly targets and negatively regulates tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catecholamine synthesis, delineating a mechanism for the KO phenotypes. Catecholamines 141-154 forkhead box O1 Mus musculus 23-28 27681312-6 2016 Finally, we found that FoxO1 directly targets and negatively regulates tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catecholamine synthesis, delineating a mechanism for the KO phenotypes. Catecholamines 141-154 tyrosine hydroxylase Mus musculus 71-91 26954460-2 2016 COMT regulates the breakdown of catecholamines, particularly dopamine, which is thought critical in maintaining cognitive function and the aetiology of schizophrenia. Catecholamines 32-46 catechol-O-methyltransferase Homo sapiens 0-4 27298202-8 2016 Furthermore, ankyrin-B(L1622I/L1622I) mice display catecholamine-dependent arrhythmias. Catecholamines 51-64 ankyrin 2, brain Mus musculus 13-22 27385593-2 2016 Beta-2 adrenoreceptor (ADRB2) is a functional G-coupled protein expressed in the vascular endothelium of lungs, alveolar walls, and the ganglions of cholinergic nerves which induces bronchodilation in response to catecholamines. Catecholamines 213-227 adrenoceptor beta 2 Homo sapiens 23-28 27554864-3 2016 Here we identify the lipid droplet protein Perilipin 5 as a catecholamine-triggered interaction partner of PGC-1alpha. Catecholamines 60-73 perilipin 5 Homo sapiens 43-54 27405316-3 2016 To evaluate the involvement of tyrosine hydroxylase (TH), the rate-limiting step in catecholamine biosynthesis, we treated rats with the TH inhibitor, alpha-methyl-para-tyrosine (alpha-MPT), for 3 days prior to administration of DEX and assessed TH mRNA and protein expression by quantitative real-time polymerase chain reaction and Western blot in the adrenal medulla. Catecholamines 84-97 tyrosine hydroxylase Rattus norvegicus 53-55 27564542-2 2016 Simulations and experiments have identified divergent catecholamine substrate orientations in the COMT active site: molecular dynamics simulations have favored a monodentate coordination of catecholate substrates to the active site Mg2+, and crystal structures instead preserve bidentate coordination along with short (2.65 A) methyl donor-acceptor distances. Catecholamines 54-67 catechol-O-methyltransferase Homo sapiens 98-102 27626030-3 2016 Nicotine also induces tyrosine hydroxylase (TH) gene expression, leading to increased synthesis of catecholamines. Catecholamines 99-113 tyrosine hydroxylase Homo sapiens 22-42 27626030-3 2016 Nicotine also induces tyrosine hydroxylase (TH) gene expression, leading to increased synthesis of catecholamines. Catecholamines 99-113 tyrosine hydroxylase Homo sapiens 44-46 27554864-3 2016 Here we identify the lipid droplet protein Perilipin 5 as a catecholamine-triggered interaction partner of PGC-1alpha. Catecholamines 60-73 PPARG coactivator 1 alpha Homo sapiens 107-117 27554864-4 2016 We report that during catecholamine-stimulated lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus. Catecholamines 22-35 perilipin 5 Homo sapiens 58-69 27554864-4 2016 We report that during catecholamine-stimulated lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus. Catecholamines 22-35 PPARG coactivator 1 alpha Homo sapiens 149-159 27554864-4 2016 We report that during catecholamine-stimulated lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus. Catecholamines 22-35 sirtuin 1 Homo sapiens 164-169 27554864-7 2016 We propose that Perilipin 5 is an important molecular link that couples the coordinated catecholamine activation of the PKA pathway and of lipid droplet lipolysis with transcriptional regulation to promote efficient fatty acid catabolism and prevent mitochondrial dysfunction. Catecholamines 88-101 perilipin 5 Homo sapiens 16-27 27415768-1 2016 Catestatin (CST) was first named in 1997 for its catecholamine-inhibitory activity. Catecholamines 49-62 chromogranin A Homo sapiens 0-10 26919286-2 2016 Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine. Catecholamines 42-55 catechol-O-methyltransferase Rattus norvegicus 0-29 26919286-2 2016 Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine. Catecholamines 42-55 catechol-O-methyltransferase Rattus norvegicus 31-35 27415768-1 2016 Catestatin (CST) was first named in 1997 for its catecholamine-inhibitory activity. Catecholamines 49-62 chromogranin A Homo sapiens 12-15 27346174-5 2016 The ultraviolet-visible absorption of alpha-Toc( ) (lambdamax = 428 nm), which was produced by the reaction of alpha-tocopherol (alpha-TocH) with ArO( ), disappeared under the coexistence of CAs due to the alpha-TocH-regeneration reaction. Catecholamines 191-194 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 146-149 27462005-1 2016 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. Catecholamines 82-95 tyrosine hydroxylase Homo sapiens 0-20 27462005-1 2016 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. Catecholamines 82-95 tyrosine hydroxylase Homo sapiens 22-24 27354517-2 2016 In response to elevated catecholamine stimulation during development of congestive heart failure (CHF), chronic activation of Gs-dependent beta1AR and Gi-dependent beta2AR pathways leads to enhanced cardiomyocyte death, reduced beta1AR expression, and decreased inotropic reserve. Catecholamines 24-37 adrenergic receptor, beta 1 Mus musculus 139-146 27354517-2 2016 In response to elevated catecholamine stimulation during development of congestive heart failure (CHF), chronic activation of Gs-dependent beta1AR and Gi-dependent beta2AR pathways leads to enhanced cardiomyocyte death, reduced beta1AR expression, and decreased inotropic reserve. Catecholamines 24-37 adrenergic receptor, beta 2 Mus musculus 164-171 27354517-2 2016 In response to elevated catecholamine stimulation during development of congestive heart failure (CHF), chronic activation of Gs-dependent beta1AR and Gi-dependent beta2AR pathways leads to enhanced cardiomyocyte death, reduced beta1AR expression, and decreased inotropic reserve. Catecholamines 24-37 adrenergic receptor, beta 1 Mus musculus 228-235 27354517-3 2016 beta-blockers act to block excessive catecholamine stimulation of betaARs to decrease cellular apoptotic signaling and normalize beta1AR expression and inotropy. Catecholamines 37-50 adrenergic receptor, beta 1 Mus musculus 129-136 27342860-2 2016 Because functional cells cannot be deprived of ATP, we have knocked down the expression of the vesicular nucleotide carrier, the VNUT, to show that a reduction in vesicular ATP is accompanied by a drastic fall in the quantal release of catecholamines. Catecholamines 236-250 solute carrier family 17 member 9 Homo sapiens 129-133 27166283-0 2016 AP2-NR4A3 transgenic mice display reduced serum epinephrine because of increased catecholamine catabolism in adipose tissue. Catecholamines 81-94 fatty acid binding protein 4, adipocyte Mus musculus 0-3 27379911-1 2016 BACKGROUND: Catecholamine infusion elicits an increase in clotting factors and this increase has been attributed to stimulation of beta2-adrenorecptors (beta2AR). Catecholamines 12-25 adrenoceptor beta 2 Homo sapiens 131-151 27379911-1 2016 BACKGROUND: Catecholamine infusion elicits an increase in clotting factors and this increase has been attributed to stimulation of beta2-adrenorecptors (beta2AR). Catecholamines 12-25 adrenoceptor beta 2 Homo sapiens 153-160 27166283-0 2016 AP2-NR4A3 transgenic mice display reduced serum epinephrine because of increased catecholamine catabolism in adipose tissue. Catecholamines 81-94 nuclear receptor subfamily 4, group A, member 3 Mus musculus 4-9 27166283-6 2016 AP2-NR4A3 mice also display a significant reduction in serum epinephrine due to increased expression of catecholamine-catabolizing enzymes in adipose tissue, including monoamine oxidase-A. Catecholamines 104-117 fatty acid binding protein 4, adipocyte Mus musculus 0-3 27166283-6 2016 AP2-NR4A3 mice also display a significant reduction in serum epinephrine due to increased expression of catecholamine-catabolizing enzymes in adipose tissue, including monoamine oxidase-A. Catecholamines 104-117 nuclear receptor subfamily 4, group A, member 3 Mus musculus 4-9 27166283-9 2016 In conclusion, overexpression of NR4A3 in adipocytes produces a complex phenotype characterized by impaired glucose metabolism and low serum catecholamines due to enhanced degradation by adipose tissue. Catecholamines 141-155 nuclear receptor subfamily 4, group A, member 3 Mus musculus 33-38 27560796-2 2016 Thermogenic response is associated with alternatively activated macrophages producing catecholamines, which subsequently activate the uncoupling protein 1 (UCP-1). Catecholamines 86-100 uncoupling protein 1 Rattus norvegicus 134-161 27560796-7 2016 Induction of non-sympathetical catecholamine production was observed 7 days after cold exposure by elevated TH and phenylethanolamine-N-methyltransferase (PNMT) expression, leading to an increased epinephrine levels. Catecholamines 31-44 phenylethanolamine-N-methyltransferase Rattus norvegicus 115-153 27560796-7 2016 Induction of non-sympathetical catecholamine production was observed 7 days after cold exposure by elevated TH and phenylethanolamine-N-methyltransferase (PNMT) expression, leading to an increased epinephrine levels. Catecholamines 31-44 phenylethanolamine-N-methyltransferase Rattus norvegicus 155-159 27282867-2 2016 Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 21-49 27282867-2 2016 Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 51-55 27237441-12 2016 F-18 DOPA is promising tracer that reflects catecholamine metabolism and is both sensitive and specific. Catecholamines 44-57 mastermind like domain containing 1 Homo sapiens 0-4 27273361-5 2016 Diabetic Cav2.2(-/-) mice significantly reduced urinary albumin excretion, glomerular hyperfiltration, blood glucose levels, histological deterioration and systolic blood pressure (SBP) with decreased urinary catecholamine compared to diabetic Cav2.2(+/+) mice. Catecholamines 209-222 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 9-15 27117748-1 2016 Type 5 adenylyl cyclase (AC5) plays an important role in the development of chronic catecholamine stress-induced heart failure and arrhythmia in mice. Catecholamines 84-97 adenylate cyclase 5 Mus musculus 25-28 26582803-1 2016 Catechol-O-methyltransferase (COMT) plays an important role in the deactivation of catecholamine neurotransmitters and hormones. Catecholamines 83-96 catechol-O-methyltransferase Homo sapiens 0-28 26582803-1 2016 Catechol-O-methyltransferase (COMT) plays an important role in the deactivation of catecholamine neurotransmitters and hormones. Catecholamines 83-96 catechol-O-methyltransferase Homo sapiens 30-34 27095027-2 2016 To identify factors that regulate the presynaptic synthesis of catecholamines, we tested the hypothesis that the rate-limiting enzyme of the catecholamine biosynthetic pathway, tyrosine hydroxylase (TH), is locally synthesized in axons and presynaptic nerve terminals of noradrenergic neurons. Catecholamines 63-77 tyrosine hydroxylase Rattus norvegicus 177-197 27095027-2 2016 To identify factors that regulate the presynaptic synthesis of catecholamines, we tested the hypothesis that the rate-limiting enzyme of the catecholamine biosynthetic pathway, tyrosine hydroxylase (TH), is locally synthesized in axons and presynaptic nerve terminals of noradrenergic neurons. Catecholamines 63-77 tyrosine hydroxylase Rattus norvegicus 199-201 27095027-2 2016 To identify factors that regulate the presynaptic synthesis of catecholamines, we tested the hypothesis that the rate-limiting enzyme of the catecholamine biosynthetic pathway, tyrosine hydroxylase (TH), is locally synthesized in axons and presynaptic nerve terminals of noradrenergic neurons. Catecholamines 63-76 tyrosine hydroxylase Rattus norvegicus 177-197 27095027-2 2016 To identify factors that regulate the presynaptic synthesis of catecholamines, we tested the hypothesis that the rate-limiting enzyme of the catecholamine biosynthetic pathway, tyrosine hydroxylase (TH), is locally synthesized in axons and presynaptic nerve terminals of noradrenergic neurons. Catecholamines 63-76 tyrosine hydroxylase Rattus norvegicus 199-201 27018708-7 2016 Together, these studies reveal a signaling pathway from betaARs and PKA through mTORC1 that is required for adipose browning by catecholamines and provides potential therapeutic strategies to enhance energy expenditure and combat metabolic disease. Catecholamines 128-142 CREB regulated transcription coactivator 1 Mus musculus 80-86 27496485-2 2016 Recently chronic kidney disease and renalase metabolism of endogenous catecholamines are thought to make major contribution to the pathogenesis of hypertension. Catecholamines 70-84 renalase, FAD dependent amine oxidase Homo sapiens 36-44 26996544-0 2016 Synthetic catecholamine triggers beta1-adrenergic receptor activation and stimulates cardiotoxicity via oxidative stress mediated apoptotic cell death in rats: Abrogating action of thymol. Catecholamines 10-23 adrenoceptor beta 1 Rattus norvegicus 33-58 26880342-7 2016 Concurrently, expression of the catecholamine degrading enzymes monoamine oxidase A (MAO-A) and catechol-O-methyltransferase (COMT) was significantly upregulated in immune cells of the spleen. Catecholamines 32-45 monoamine oxidase A Mus musculus 64-83 27138453-5 2016 Our analysis of the dynamic data provides support for the hypothesis that activation of Ca2+-dependent adenylyl cyclases play a critical role in modulating the effects of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and catecholamines. Catecholamines 259-273 glucagon Homo sapiens 171-194 26950706-1 2016 BACKGROUND: Patients with chronic pain disorders exhibit increased levels of catecholamines alongside diminished activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Catecholamines 189-203 catechol-O-methyltransferase Homo sapiens 125-153 26950706-1 2016 BACKGROUND: Patients with chronic pain disorders exhibit increased levels of catecholamines alongside diminished activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Catecholamines 189-203 catechol-O-methyltransferase Homo sapiens 155-159 26880342-7 2016 Concurrently, expression of the catecholamine degrading enzymes monoamine oxidase A (MAO-A) and catechol-O-methyltransferase (COMT) was significantly upregulated in immune cells of the spleen. Catecholamines 32-45 monoamine oxidase A Mus musculus 85-90 26880342-7 2016 Concurrently, expression of the catecholamine degrading enzymes monoamine oxidase A (MAO-A) and catechol-O-methyltransferase (COMT) was significantly upregulated in immune cells of the spleen. Catecholamines 32-45 catechol-O-methyltransferase Mus musculus 96-124 26880342-7 2016 Concurrently, expression of the catecholamine degrading enzymes monoamine oxidase A (MAO-A) and catechol-O-methyltransferase (COMT) was significantly upregulated in immune cells of the spleen. Catecholamines 32-45 catechol-O-methyltransferase Mus musculus 126-130 26953321-10 2016 Hypersensitivity to leptin and obesity reduced BP response to ganglionic blockade in both strains and plasma catecholamine levels in protein tyrosine phosphatase 1b knockout mice. Catecholamines 109-122 leptin Mus musculus 20-26 26572541-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine. Catecholamines 74-88 tyrosine hydroxylase Danio rerio 0-20 26572541-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine. Catecholamines 74-88 tyrosine hydroxylase Danio rerio 22-24 27083074-6 2016 TGF-beta in vitro was increased by 23.4% using catecholamines (p < 0.012) and in vivo employing chronic stress (p < 0.001). Catecholamines 47-61 transforming growth factor, beta 1 Mus musculus 0-8 27124282-1 2016 BACKGROUND: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is secreted from adipocytes in association with catecholamine-induced lipolysis, and elevated serum FABP4 level is associated with obesity, insulin resistance and atherosclerosis. Catecholamines 108-121 fatty acid binding protein 4 Homo sapiens 12-40 27124282-1 2016 BACKGROUND: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is secreted from adipocytes in association with catecholamine-induced lipolysis, and elevated serum FABP4 level is associated with obesity, insulin resistance and atherosclerosis. Catecholamines 108-121 fatty acid binding protein 4 Homo sapiens 42-47 27124282-1 2016 BACKGROUND: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is secreted from adipocytes in association with catecholamine-induced lipolysis, and elevated serum FABP4 level is associated with obesity, insulin resistance and atherosclerosis. Catecholamines 108-121 fatty acid binding protein 4 Homo sapiens 48-54 27124282-1 2016 BACKGROUND: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is secreted from adipocytes in association with catecholamine-induced lipolysis, and elevated serum FABP4 level is associated with obesity, insulin resistance and atherosclerosis. Catecholamines 108-121 fatty acid binding protein 4 Homo sapiens 55-58 26969276-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 0-20 26969276-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 22-24 26969276-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 156-170 tyrosine hydroxylase Rattus norvegicus 0-20 26969276-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its stability is a fundamental factor to maintain the level of the catecholamines in cells. Catecholamines 156-170 tyrosine hydroxylase Rattus norvegicus 22-24 27031468-8 2016 When PS1IV is absent under hypoxia-like conditions, we observe changes in expression of genes controlling inflammation (particularly sAD-associated IL1B and CCR5), vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation. Catecholamines 235-248 presenilin 1 Danio rerio 5-8 26399932-14 2016 CONCLUSION: IGF-1 treatment attenuates diastolic and systolic dysfunction associated with chronic catecholamine-induced cardiomyopathy while preserving adrenergic sensitivity and promoting BH4 production. Catecholamines 98-111 insulin-like growth factor 1 Rattus norvegicus 12-17 26263484-4 2016 Circulating catecholamines were estimated by salivary alpha-amylase (sAA) assay. Catecholamines 12-26 amylase alpha 1A Homo sapiens 69-72 26499437-2 2016 Although catecholamine-induced lipolysis is well known to be impaired in obesity and insulin resistance, it is not known whether the effect of NPs is also altered. Catecholamines 9-22 insulin Homo sapiens 85-92 27057898-9 2016 In our case, the serious stenosis in the mid of LAD could be explained by worsen the clinical course of myocardial ischemia or severe coronary vasospasm by the excessive amounts of catecholamines released from the tumor. Catecholamines 181-195 dihydrolipoamide dehydrogenase Homo sapiens 48-51 26620190-0 2016 Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization. Catecholamines 22-35 succinate dehydrogenase complex iron sulfur subunit B Rattus norvegicus 8-12 26620190-6 2016 Lack of complex II activity resulting from RNA interference of SDHB increased tyrosine hydroxylase (TH; the rate-limiting enzyme in catecholamine biosynthesis) activity and catecholamine secretion. Catecholamines 132-145 succinate dehydrogenase complex iron sulfur subunit B Rattus norvegicus 63-67 26620190-6 2016 Lack of complex II activity resulting from RNA interference of SDHB increased tyrosine hydroxylase (TH; the rate-limiting enzyme in catecholamine biosynthesis) activity and catecholamine secretion. Catecholamines 173-186 succinate dehydrogenase complex iron sulfur subunit B Rattus norvegicus 63-67 26620190-11 2016 To our knowledge, this is the first study demonstrating that pseudo-hypoxic states resulting from SDHB knockdown are associated with increased TH activity and catecholamine oversecretion. Catecholamines 159-172 succinate dehydrogenase complex iron sulfur subunit B Rattus norvegicus 98-102 26761434-1 2016 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 26761434-1 2016 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 27155338-1 2016 BACKGROUND: Renalase is a novel enzyme that degrades circulating catecholamines. Catecholamines 65-79 renalase, FAD dependent amine oxidase Homo sapiens 12-20 26797688-1 2016 BACKGROUND: CREB-regulated transcription coactivator 3 (CRTC3) is found in adipocytes, where it may promote obesity through disruption of catecholamine signaling. Catecholamines 138-151 CREB regulated transcription coactivator 3 Homo sapiens 12-54 26739108-0 2016 ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells. Catecholamines 24-37 mitogen-activated protein kinase 7 Rattus norvegicus 0-4 26739108-0 2016 ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells. Catecholamines 24-37 ankyrin repeat domain 1 Rattus norvegicus 13-19 26739108-6 2016 Here, we report a novel role of the ERK5/ankrd1 signaling in regulating TH levels and catecholamine biosynthesis. Catecholamines 86-99 mitogen-activated protein kinase 7 Rattus norvegicus 36-40 26739108-6 2016 Here, we report a novel role of the ERK5/ankrd1 signaling in regulating TH levels and catecholamine biosynthesis. Catecholamines 86-99 ankyrin repeat domain 1 Rattus norvegicus 41-47 26739108-9 2016 Interestingly, ubiquitination of TH was enhanced and catecholamine biosynthesis was reduced by ankrd1 knockdown. Catecholamines 53-66 ankyrin repeat domain 1 Rattus norvegicus 95-101 26739108-12 2016 Taken together, ERK5 signaling is required for catecholamine biosynthesis during neural differentiation, in part to induce ankrd1, and to maintain appropriate TH levels. Catecholamines 47-60 mitogen-activated protein kinase 7 Rattus norvegicus 16-20 26739108-12 2016 Taken together, ERK5 signaling is required for catecholamine biosynthesis during neural differentiation, in part to induce ankrd1, and to maintain appropriate TH levels. Catecholamines 47-60 ankyrin repeat domain 1 Rattus norvegicus 123-129 26739108-12 2016 Taken together, ERK5 signaling is required for catecholamine biosynthesis during neural differentiation, in part to induce ankrd1, and to maintain appropriate TH levels. Catecholamines 47-60 tyrosine hydroxylase Rattus norvegicus 159-161 26572539-4 2016 Adrenomedullary content of the secreted adrenal catecholamines norepinephrine (NE) and epinephrine (EPI) was decreased 30-40 % in Chga-KO mice. Catecholamines 48-62 chromogranin A Mus musculus 130-134 26572539-8 2016 Chga-KO mice showed an ~47 % increase in DCV/DC ratio, implying vesicle swelling due to increased osmotically active free catecholamines. Catecholamines 122-136 chromogranin A Mus musculus 0-4 26797688-1 2016 BACKGROUND: CREB-regulated transcription coactivator 3 (CRTC3) is found in adipocytes, where it may promote obesity through disruption of catecholamine signaling. Catecholamines 138-151 CREB regulated transcription coactivator 3 Homo sapiens 56-61 26700559-1 2016 CONTEXT: Pheochromocytoma is a catecholamine-producing tumor that originates from adrenal chromaffin cells and is capable of secreting various hormones, including ACTH. Catecholamines 31-44 proopiomelanocortin Homo sapiens 163-167 26700559-3 2016 Endocrinological examinations demonstrated ectopic ACTH production with hypercortisolemia and excess urinary cortisol accompanied by elevated plasma and urine catecholamines. Catecholamines 159-173 proopiomelanocortin Homo sapiens 51-55 26538443-10 2016 For example, pendrin is expressed in the adrenal medulla, where it modulates catecholamine release. Catecholamines 77-90 solute carrier family 26, member 4 Mus musculus 13-20 26849467-0 2016 GRK2 Up-Regulation Creates a Positive Feedback Loop for Catecholamine Production in Chromaffin Cells. Catecholamines 56-69 G protein-coupled receptor kinase 2 Rattus norvegicus 0-4 26849467-3 2016 We have previously uncovered a neurohormonal mechanism, operating in adrenomedullary chromaffin cells, by which circulating catecholamine (CA) levels increase in heart failure: severe dysfunction of the adrenal alpha2-adrenergic receptors (ARs) due to the up-regulation of G protein-coupled receptor-kinase (GRK)-2, the kinase that desensitizes them. Catecholamines 124-137 G protein-coupled receptor kinase 2 Rattus norvegicus 273-314 26538443-11 2016 The increase in catecholamine release observed with pendrin gene ablation likely contributes to the increment in vascular contractile force observed in the pendrin null mouse. Catecholamines 16-29 solute carrier family 26, member 4 Mus musculus 52-59 26538443-11 2016 The increase in catecholamine release observed with pendrin gene ablation likely contributes to the increment in vascular contractile force observed in the pendrin null mouse. Catecholamines 16-29 solute carrier family 26, member 4 Mus musculus 156-163 26492543-1 2016 OBJECTIVE: To describe a patient with a germline succinate dehydrogenase (SDHC) gene mutation presenting with primary hyperparathyroidism and a large catecholamine-producing temporal bone paraganglioma (PGL). Catecholamines 150-163 succinate dehydrogenase complex subunit C Homo sapiens 74-78 26681068-1 2016 Neuropeptide Y (NPY) in noradrenergic neurons plays an important role in modulating the release and effects of catecholamines in a prolonged stress response. Catecholamines 111-125 neuropeptide Y Mus musculus 0-14 26953902-0 2016 Toward catecholamine responsiveness in cardiogenic shock: insights from the CRASH score. Catecholamines 7-20 asparaginase and isoaspartyl peptidase 1 Homo sapiens 76-81 26953902-2 2016 METHODS: Assessment of the best accuracy of the score (CRASH score: Catecholamine Refractoriness and Assistance guide based on cardiogenic Shock Hemodynamics) to predict in-hospital mortality and/or extracorporeal life support, based on a retrospective study performed in a medical-surgical intensive care unit. Catecholamines 68-81 asparaginase and isoaspartyl peptidase 1 Homo sapiens 55-60 26953902-5 2016 The CRASH score was defined as the cardiac power index (CPI) divided by the square root of 1 + inotropic score (IS, sum of different catecholamines pondered with their variable efficiency): CRASH score = CPI/square root (IS + 1). Catecholamines 133-147 asparaginase and isoaspartyl peptidase 1 Homo sapiens 4-9 26488603-7 2016 Therefore, catecholamine resistance in childhood obesity may promote insulin signaling in adipose tissue, thereby increasing lipogenesis. Catecholamines 11-24 insulin Homo sapiens 69-76 26604244-1 2016 After hindlimb ischemia (HI), increased catecholamine levels within the ischemic muscle can cause dysregulation of beta2-adrenergic receptor (beta2AR) signaling, leading to reduced revascularization. Catecholamines 40-53 adrenoceptor beta 2 Rattus norvegicus 115-140 26604244-1 2016 After hindlimb ischemia (HI), increased catecholamine levels within the ischemic muscle can cause dysregulation of beta2-adrenergic receptor (beta2AR) signaling, leading to reduced revascularization. Catecholamines 40-53 adrenoceptor beta 2 Rattus norvegicus 142-149 26869038-4 2016 Catecholamine synthesis depends on the rate-limiting enzyme, tyrosine hydroxylase, whose expression is associated with working memory and the response to chronic stress. Catecholamines 0-13 tyrosine hydroxylase Homo sapiens 61-81 26553126-1 2016 Renalase is currently the only known amine oxidase in the blood that can metabolize catecholamines and regulate sympathetic activity. Catecholamines 84-98 renalase, FAD-dependent amine oxidase Rattus norvegicus 0-8 26598443-8 2016 In IMR-32 cells, TFAP2B induced neuronal differentiation, which was accompanied by up-regulation of the catecholamine biosynthesizing enzyme genes DBH and TH, and down-regulation of MYCN and REST, a master repressor of neuronal genes. Catecholamines 104-117 transcription factor AP-2 beta Homo sapiens 17-23 26681068-1 2016 Neuropeptide Y (NPY) in noradrenergic neurons plays an important role in modulating the release and effects of catecholamines in a prolonged stress response. Catecholamines 111-125 neuropeptide Y Mus musculus 16-19 26732803-7 2016 CONCLUSION: The data suggest that presence of a homozygous V81M polymorphism is associated with more severe FOG, possibly due to lower catecholamine synthetic capacity. Catecholamines 135-148 zinc finger protein, FOG family member 1 Homo sapiens 108-111 26732803-8 2016 Further studies are warranted to investigate the role of subtle changes in catecholamine availability in the development of FOG. Catecholamines 75-88 zinc finger protein, FOG family member 1 Homo sapiens 124-127 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 4-32 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 34-38 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 120-124 27194994-4 2015 Renalase, a novel catecholamine-metabolizing amine oxidase, is synthesized mainly in proximal tubular cells and secreted into urine and blood. Catecholamines 18-31 renalase, FAD dependent amine oxidase Homo sapiens 0-8 26234518-3 2016 Two key genetic variants of the catecholamine system that have been related to emotion perception and attention are the catechol-O-methyl transferase genetic variant (COMT Val158Met) and the alpha2A-receptor gene promoter polymorphism (ADRA2A C-1291G) accordingly. Catecholamines 32-45 catechol-O-methyltransferase Homo sapiens 167-171 26234518-3 2016 Two key genetic variants of the catecholamine system that have been related to emotion perception and attention are the catechol-O-methyl transferase genetic variant (COMT Val158Met) and the alpha2A-receptor gene promoter polymorphism (ADRA2A C-1291G) accordingly. Catecholamines 32-45 adrenoceptor alpha 2A Homo sapiens 236-242 26647061-3 2016 We studied immunohistochemically the expression of tyrosine hydroxylase (TH, first limiting enzyme for catecholamine synthesis) in LC neurons of 15 autopsied infants (brains collected from the Greek Brain Bank) in relation to the neuropathological changes of acute or chronic HII of the neonatal brain. Catecholamines 103-116 tyrosine hydroxylase Homo sapiens 51-71 26647061-3 2016 We studied immunohistochemically the expression of tyrosine hydroxylase (TH, first limiting enzyme for catecholamine synthesis) in LC neurons of 15 autopsied infants (brains collected from the Greek Brain Bank) in relation to the neuropathological changes of acute or chronic HII of the neonatal brain. Catecholamines 103-116 tyrosine hydroxylase Homo sapiens 73-75 26428905-1 2016 We previously demonstrated that mice with reduced expression of the vesicular monoamine transporter 2 (VMAT2 LO) undergo age-related degeneration of the catecholamine-producing neurons of the substantia nigra pars compacta and locus ceruleus and exhibit motor disturbances and depressive-like behavior. Catecholamines 153-166 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 68-101 26428905-1 2016 We previously demonstrated that mice with reduced expression of the vesicular monoamine transporter 2 (VMAT2 LO) undergo age-related degeneration of the catecholamine-producing neurons of the substantia nigra pars compacta and locus ceruleus and exhibit motor disturbances and depressive-like behavior. Catecholamines 153-166 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 103-108 26576546-2 2016 A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 36-64 26576546-2 2016 A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. Catecholamines 98-111 catechol-O-methyltransferase Homo sapiens 66-70 26772978-3 2016 Tyrosine hydroxylase (TH) is the key enzyme for the synthesis of catecholamines, including dopamine and noradrenaline, and it is normally not expressed in cerebellar neurons. Catecholamines 65-79 tyrosine hydroxylase Mus musculus 0-20 26772978-3 2016 Tyrosine hydroxylase (TH) is the key enzyme for the synthesis of catecholamines, including dopamine and noradrenaline, and it is normally not expressed in cerebellar neurons. Catecholamines 65-79 tyrosine hydroxylase Mus musculus 22-24 25798840-4 2016 In this study, we show that the expression of beta2-AR, which mediates most catecholamine-induced effects, negatively correlates with trastuzumab response in the patients with Her2-overexpressing breast cancer. Catecholamines 76-89 adrenoceptor beta 2 Homo sapiens 46-54 25798840-4 2016 In this study, we show that the expression of beta2-AR, which mediates most catecholamine-induced effects, negatively correlates with trastuzumab response in the patients with Her2-overexpressing breast cancer. Catecholamines 76-89 erb-b2 receptor tyrosine kinase 2 Homo sapiens 176-180 25798840-6 2016 Catecholamine stimulation upregulates the expression of miR-21 and MUC-1 by activating Her2 and STAT3, leading to deficiency of phosphatase and tensin homolog and activation of phosphatidylinositol-3-kinase (PI3K) and Akt. Catecholamines 0-13 microRNA 21 Homo sapiens 56-62 25798840-6 2016 Catecholamine stimulation upregulates the expression of miR-21 and MUC-1 by activating Her2 and STAT3, leading to deficiency of phosphatase and tensin homolog and activation of phosphatidylinositol-3-kinase (PI3K) and Akt. Catecholamines 0-13 mucin 1, cell surface associated Homo sapiens 67-72 25798840-6 2016 Catecholamine stimulation upregulates the expression of miR-21 and MUC-1 by activating Her2 and STAT3, leading to deficiency of phosphatase and tensin homolog and activation of phosphatidylinositol-3-kinase (PI3K) and Akt. Catecholamines 0-13 erb-b2 receptor tyrosine kinase 2 Homo sapiens 87-91 25798840-6 2016 Catecholamine stimulation upregulates the expression of miR-21 and MUC-1 by activating Her2 and STAT3, leading to deficiency of phosphatase and tensin homolog and activation of phosphatidylinositol-3-kinase (PI3K) and Akt. Catecholamines 0-13 signal transducer and activator of transcription 3 Homo sapiens 96-101 25798840-6 2016 Catecholamine stimulation upregulates the expression of miR-21 and MUC-1 by activating Her2 and STAT3, leading to deficiency of phosphatase and tensin homolog and activation of phosphatidylinositol-3-kinase (PI3K) and Akt. Catecholamines 0-13 AKT serine/threonine kinase 1 Homo sapiens 218-221 25798840-7 2016 Through inhibition of miR-199a/b-3p, catecholamines induce the mammalian target of rapamycin (mTOR) activation. Catecholamines 37-51 mechanistic target of rapamycin kinase Homo sapiens 63-92 25798840-7 2016 Through inhibition of miR-199a/b-3p, catecholamines induce the mammalian target of rapamycin (mTOR) activation. Catecholamines 37-51 mechanistic target of rapamycin kinase Homo sapiens 94-98 25798840-8 2016 Thus, trastuzumab resistance-dependent PI3K/Akt/mTOR pathway is controlled by catecholamine-induced beta2-AR activation. Catecholamines 78-91 AKT serine/threonine kinase 1 Homo sapiens 44-47 25798840-8 2016 Thus, trastuzumab resistance-dependent PI3K/Akt/mTOR pathway is controlled by catecholamine-induced beta2-AR activation. Catecholamines 78-91 mechanistic target of rapamycin kinase Homo sapiens 48-52 25798840-8 2016 Thus, trastuzumab resistance-dependent PI3K/Akt/mTOR pathway is controlled by catecholamine-induced beta2-AR activation. Catecholamines 78-91 adrenoceptor beta 2 Homo sapiens 100-108 26853286-1 2016 Arginine vasopressin as a supplementary vasopressor in septic shock restores vascular tone and mean arterial pressure, meanwhile decreases dose and exposure time to catecholamines. Catecholamines 165-179 arginine vasopressin Homo sapiens 9-20 28525692-2 2016 The majority of the principal ganglionic sympathetic neurons is noradrenergic and expresses tyrosine hydroxylase (TH), i.e., a key enzyme in catecholamine synthesis. Catecholamines 141-154 tyrosine hydroxylase Homo sapiens 92-112 25900362-2 2016 Throughout the prior decade a consensus belief that renalase is produced predominantly by the kidney and catalytically oxidizes catecholamines in order to lower blood pressure and slow the heart has prevailed. Catecholamines 128-142 renalase, FAD dependent amine oxidase Homo sapiens 52-60 25900362-8 2016 Renalase oxidizes these substrates with rate constants that are up to 10(4)-fold faster than any claimed for catecholamines. Catecholamines 109-123 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25900362-11 2016 The identification of this genuinely catalytic activity for renalase calls for re-evaluation of much of the research of this enzyme, in which definitive links between renalase catecholamine consumption and physiological responses were reported. Catecholamines 176-189 renalase, FAD dependent amine oxidase Homo sapiens 60-68 25900362-11 2016 The identification of this genuinely catalytic activity for renalase calls for re-evaluation of much of the research of this enzyme, in which definitive links between renalase catecholamine consumption and physiological responses were reported. Catecholamines 176-189 renalase, FAD dependent amine oxidase Homo sapiens 167-175 26931475-7 2016 Recently, a phase 3 trial using infused angiotensin II (LJPC-501) as treatment option in catecholamine-resistent hypotension was established (ClinicalTrials.gov identifier NCT02338843) although it might be that an influence of AngII-derived peptides is not considered. Catecholamines 89-102 angiotensinogen Homo sapiens 40-54 26843961-12 2016 The macroscopic black aspect can mislead to the diagnosis of a metastasis deriving from a malignant melanoma.RET mutation are seen in catecholamine and non-catecholamine producing tumors of the same cellular origin. Catecholamines 134-147 ret proto-oncogene Homo sapiens 109-112 26843961-12 2016 The macroscopic black aspect can mislead to the diagnosis of a metastasis deriving from a malignant melanoma.RET mutation are seen in catecholamine and non-catecholamine producing tumors of the same cellular origin. Catecholamines 156-169 ret proto-oncogene Homo sapiens 109-112 26889257-2 2016 Catecholamines have been indicated to exert an enhancing effect on the IL-1beta release. Catecholamines 0-14 interleukin 1 beta Homo sapiens 71-79 26889257-3 2016 The aim of the present study was to determine whether alterations in inflammasome gene expression may be responsible for the modified IL-1beta and IL-18 secretion following lipopolysaccharide (LPS) and catecholamine co-stimulation. Catecholamines 202-215 interleukin 1 beta Homo sapiens 134-142 26889257-3 2016 The aim of the present study was to determine whether alterations in inflammasome gene expression may be responsible for the modified IL-1beta and IL-18 secretion following lipopolysaccharide (LPS) and catecholamine co-stimulation. Catecholamines 202-215 interleukin 18 Homo sapiens 147-152 26556564-1 2016 OBJECTIVE: The human prohormone chromogranin A (CHGA), an index member of the granin family is processed to generate catestatin, a peptide that is hypotensive in action and modulates catecholamine release within the sympathoadrenal system. Catecholamines 183-196 chromogranin A Homo sapiens 32-46 26556564-1 2016 OBJECTIVE: The human prohormone chromogranin A (CHGA), an index member of the granin family is processed to generate catestatin, a peptide that is hypotensive in action and modulates catecholamine release within the sympathoadrenal system. Catecholamines 183-196 chromogranin A Homo sapiens 48-52 26556564-1 2016 OBJECTIVE: The human prohormone chromogranin A (CHGA), an index member of the granin family is processed to generate catestatin, a peptide that is hypotensive in action and modulates catecholamine release within the sympathoadrenal system. Catecholamines 183-196 chromogranin A Homo sapiens 117-127 26612065-3 2016 In the present study, the effect of the stress-related catecholamine adrenaline on the expression of TGF-beta isoforms in RAW264.7 macrophages and murine bone marrow-derived macrophages was examined. Catecholamines 55-68 transforming growth factor, beta 1 Mus musculus 101-109 26612065-9 2016 Adrenoceptor-mediated TGF-beta3 expression by macrophages may influence immune regulation and tissue repair in conditions of stress, during which the sympathetic-nervous system releases catecholamines. Catecholamines 186-200 transforming growth factor, beta 3 Mus musculus 22-31 28190014-2 2016 Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). Catecholamines 29-43 solute carrier family 7 member 5 Homo sapiens 129-160 28190014-2 2016 Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). Catecholamines 29-43 solute carrier family 7 member 5 Homo sapiens 162-166 28190014-3 2016 The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5/LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy controls to investigate genetic vulnerability to the disorder as well as genetic relationships to homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the major catecholamine metabolites in the cerebrospinal fluid (CSF). Catecholamines 361-374 solute carrier family 7 member 5 Homo sapiens 87-93 28190014-3 2016 The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5/LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy controls to investigate genetic vulnerability to the disorder as well as genetic relationships to homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the major catecholamine metabolites in the cerebrospinal fluid (CSF). Catecholamines 361-374 solute carrier family 7 member 5 Homo sapiens 94-98 28044091-6 2016 Catalase and aldehyde dehydrogenase-2 activities (ALDH-2), both implicated in MAO-catalyzed catecholamine catabolism, were significantly elevated in the failing LV, whereas, in the RV, statistical significance was observed only for ALDH-2. Catecholamines 92-105 catalase Homo sapiens 0-8 28044091-6 2016 Catalase and aldehyde dehydrogenase-2 activities (ALDH-2), both implicated in MAO-catalyzed catecholamine catabolism, were significantly elevated in the failing LV, whereas, in the RV, statistical significance was observed only for ALDH-2. Catecholamines 92-105 aldehyde dehydrogenase 2 family member Homo sapiens 13-37 28044091-6 2016 Catalase and aldehyde dehydrogenase-2 activities (ALDH-2), both implicated in MAO-catalyzed catecholamine catabolism, were significantly elevated in the failing LV, whereas, in the RV, statistical significance was observed only for ALDH-2. Catecholamines 92-105 aldehyde dehydrogenase 2 family member Homo sapiens 50-56 26469763-2 2015 By applying different modification protocols, TTF-Au wires were successfully used for sensitive label-free detection of catecholamines and human IgG by Raman spectroscopy. Catecholamines 120-134 ras homolog family member H Homo sapiens 46-49 26523867-4 2015 In contrast, myeloid-specific deletion of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, protected mice against EAE. Catecholamines 97-110 tyrosine hydroxylase Mus musculus 42-62 26241318-4 2015 These solution properties are consistent with the regulatory mechanisms of the two enzymes, in that phenylalanine hydroxylase is activated by phenylalanine binding to an allosteric site, while tyrosine hydroxylase is regulated by binding of catecholamines in the active site. Catecholamines 241-255 phenylalanine hydroxylase Homo sapiens 100-125 26241318-4 2015 These solution properties are consistent with the regulatory mechanisms of the two enzymes, in that phenylalanine hydroxylase is activated by phenylalanine binding to an allosteric site, while tyrosine hydroxylase is regulated by binding of catecholamines in the active site. Catecholamines 241-255 tyrosine hydroxylase Homo sapiens 193-213 26190314-0 2015 Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model. Catecholamines 74-87 internexin neuronal intermediate filament protein alpha Sus scrofa 15-18 26190314-10 2015 CONCLUSION: Selective cardiac late INa inhibition with GS-967 confers significant protection against catecholamine-induced VT and TWA. Catecholamines 101-114 internexin neuronal intermediate filament protein alpha Sus scrofa 35-38 26562783-1 2015 Tyrosine hydroxylase (TH, the rate limiting-enzyme in catecholamine synthesis) is regulated acutely via phosphorylation of 3 serine residues--Ser19, 31 and 40, and chronically via changes in TH protein levels. Catecholamines 54-67 tyrosine hydroxylase Rattus norvegicus 0-20 26562783-1 2015 Tyrosine hydroxylase (TH, the rate limiting-enzyme in catecholamine synthesis) is regulated acutely via phosphorylation of 3 serine residues--Ser19, 31 and 40, and chronically via changes in TH protein levels. Catecholamines 54-67 tyrosine hydroxylase Rattus norvegicus 22-24 25640985-1 2015 AIMS: The enzyme catechol-O-methyltransferase (COMT) plays a primary role in the metabolism of catecholamine neurotransmitters and is implicated in the modulation of cognitive and emotional responses. Catecholamines 95-108 catechol-O-methyltransferase Homo sapiens 17-45 26523867-4 2015 In contrast, myeloid-specific deletion of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, protected mice against EAE. Catecholamines 97-110 tyrosine hydroxylase Mus musculus 64-66 25640985-1 2015 AIMS: The enzyme catechol-O-methyltransferase (COMT) plays a primary role in the metabolism of catecholamine neurotransmitters and is implicated in the modulation of cognitive and emotional responses. Catecholamines 95-108 catechol-O-methyltransferase Homo sapiens 47-51 26523867-6 2015 Our data reveal a new role for macrophages in neuroinflammation and identify Nr4a1 as a key regulator of catecholamine production by macrophages. Catecholamines 105-118 nuclear receptor subfamily 4, group A, member 1 Mus musculus 77-82 26334033-8 2015 In contrast, P3Kgamma(+/+) mice and PI3Kgamma(KD/KD) mice developed an early and ongoing myocardial depression despite exposure to similarly increased catecholamine levels. Catecholamines 151-164 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 36-52 25894681-9 2015 The catecholamine VT targeting astroglia can modulate the fundamental functions of astroglia observed in neuroenergetics, in the Glymphatic system, in the central renin-angiotensin system and in the production of long-distance calcium waves. Catecholamines 4-17 renin Homo sapiens 163-168 26567709-1 2015 Catestatin (CST) is a catecholamine secretion inhibiting peptide as non-competitive inhibitor of nicotinic acetylcholine receptor. Catecholamines 22-35 chromogranin A Homo sapiens 0-10 26567709-1 2015 Catestatin (CST) is a catecholamine secretion inhibiting peptide as non-competitive inhibitor of nicotinic acetylcholine receptor. Catecholamines 22-35 chromogranin A Homo sapiens 12-15 26408198-3 2015 By means of a combination of whole-cell patch-clamp and Forster resonance energy transfer (FRET) in single cells, we demonstrate that the activation of the Gs-coupled beta1-adrenoreceptor (beta1-AR) by the catecholamines isoprenaline (Iso) and adrenaline (Adr) is regulated by V(M). Catecholamines 206-220 adrenoceptor beta 1 Homo sapiens 167-187 26408198-3 2015 By means of a combination of whole-cell patch-clamp and Forster resonance energy transfer (FRET) in single cells, we demonstrate that the activation of the Gs-coupled beta1-adrenoreceptor (beta1-AR) by the catecholamines isoprenaline (Iso) and adrenaline (Adr) is regulated by V(M). Catecholamines 206-220 adrenoceptor beta 1 Homo sapiens 189-197 26716738-6 2015 Results of the Aliverti"s group on NAD(P)H binding by renalase and weak diaphorase activity of this protein stimulated further studies of renalase as NAD(P)H oxidase catalyzing reaction of catecholamine co-oxidation. Catecholamines 189-202 renalase, FAD dependent amine oxidase Homo sapiens 138-146 26282459-0 2015 Dual action of leptin on rest-firing and stimulated catecholamine release via phosphoinositide 3-kinase-driven BK channel up-regulation in mouse chromaffin cells. Catecholamines 52-65 leptin Mus musculus 15-21 26282459-0 2015 Dual action of leptin on rest-firing and stimulated catecholamine release via phosphoinositide 3-kinase-driven BK channel up-regulation in mouse chromaffin cells. Catecholamines 52-65 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 78-103 26282459-5 2015 During sustained stimulation, leptin preserves cell excitability by generating well-adapted action potential (AP) trains of lower frequency and broader width and increases catecholamine secretion by increasing the size of the ready-releasable pool and the rate of vesicle release. Catecholamines 172-185 leptin Mus musculus 30-36 26282459-6 2015 In conclusion, leptin dampens AP firing at rest but preserves AP firing and enhances catecholamine release during sustained stimulation, highlighting the importance of the adipo-adrenal axis in the leptin-mediated increase of sympathetic tone and catecholamine release. Catecholamines 85-98 leptin Mus musculus 15-21 26282459-6 2015 In conclusion, leptin dampens AP firing at rest but preserves AP firing and enhances catecholamine release during sustained stimulation, highlighting the importance of the adipo-adrenal axis in the leptin-mediated increase of sympathetic tone and catecholamine release. Catecholamines 85-98 leptin Mus musculus 198-204 26282459-6 2015 In conclusion, leptin dampens AP firing at rest but preserves AP firing and enhances catecholamine release during sustained stimulation, highlighting the importance of the adipo-adrenal axis in the leptin-mediated increase of sympathetic tone and catecholamine release. Catecholamines 247-260 leptin Mus musculus 15-21 26282459-6 2015 In conclusion, leptin dampens AP firing at rest but preserves AP firing and enhances catecholamine release during sustained stimulation, highlighting the importance of the adipo-adrenal axis in the leptin-mediated increase of sympathetic tone and catecholamine release. Catecholamines 247-260 leptin Mus musculus 198-204 26282459-19 2015 It dampens AP firing at rest but preserves AP firing and increases catecholamine secretion during sustained stimulation, highlighting the importance of the adipo-adrenal axis in the leptin-mediated increase of sympathetic tone and catecholamine release. Catecholamines 231-244 leptin Mus musculus 182-188 26558621-6 2015 Thus, in recent years, interest in catecholamine-sparing agents such as vasopressin, terlipressin and methylene blue has increased; however, few randomized trials, mostly with small sample sizes, have been performed. Catecholamines 35-48 arginine vasopressin Homo sapiens 72-83 26187567-3 2015 A recent in vitro study further demonstrates that increased NF-kappaB activity in astrocytes decreases transcription of catechol-o-methyltransferase (COMT), an enzyme that inactivates catecholamines that cause pain. Catecholamines 184-198 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 60-69 26187567-3 2015 A recent in vitro study further demonstrates that increased NF-kappaB activity in astrocytes decreases transcription of catechol-o-methyltransferase (COMT), an enzyme that inactivates catecholamines that cause pain. Catecholamines 184-198 catechol-O-methyltransferase Rattus norvegicus 120-148 26187567-3 2015 A recent in vitro study further demonstrates that increased NF-kappaB activity in astrocytes decreases transcription of catechol-o-methyltransferase (COMT), an enzyme that inactivates catecholamines that cause pain. Catecholamines 184-198 catechol-O-methyltransferase Rattus norvegicus 150-154 26251232-1 2015 Numerous studies demonstrate that the Methionine variant of the catechol-O-methyltransferase Val158Met polymorphism, which confers less efficient catabolism of catecholamines, is associated with increased focal activation of prefrontal cortex (PFC) and higher levels of executive function abilities. Catecholamines 160-174 catechol-O-methyltransferase Homo sapiens 64-92 26251232-3 2015 Effects of early adversity on stress response physiology and the inverted U shape relating catecholamine levels to neural activity in PFC indicate the need to take into account early experience when considering relations between genes such as COMT and executive cognitive ability. Catecholamines 91-104 catechol-O-methyltransferase Homo sapiens 243-247 26251232-5 2015 Specifically, the Valine variant of the COMT Val158Met polymorphism, which confers more rather than less efficient catabolism of catecholamines is associated with higher executive function abilities at child ages 48 and 60 months and with faster growth of executive function for children experiencing early adversity, as indexed by cumulative risk factors in the home at child ages 7, 15, 24, and 36 months. Catecholamines 129-143 catechol-O-methyltransferase Homo sapiens 40-44 26475702-2 2015 The aim of the current study was to examine the impact of prenatal GC exposure on the postnatal regulation of the gene encoding for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the biosynthesis of the catecholamine, epinephrine. Catecholamines 226-239 phenylethanolamine-N-methyltransferase Rattus norvegicus 132-170 26403854-3 2015 The correlation between renalase, VAP-1 levels and catecholamine concentration in blood, blood pressure control, pharmacological therapy, and medical history were taken in to consideration. Catecholamines 51-64 amine oxidase copper containing 3 Homo sapiens 34-39 26475702-2 2015 The aim of the current study was to examine the impact of prenatal GC exposure on the postnatal regulation of the gene encoding for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the biosynthesis of the catecholamine, epinephrine. Catecholamines 226-239 phenylethanolamine-N-methyltransferase Rattus norvegicus 172-176 26689075-13 2015 Moreover, vasopressin may be utilized to treat catecholamine-resistant hypotension. Catecholamines 47-60 arginine vasopressin Homo sapiens 10-21 25744051-5 2015 In this review, we will focus on the role of leptin in glucose homeostasis at the central level and its role in insulin secretion and in counteracting hormones, such as glucagon, growth hormone, cortisol and catecholamines. Catecholamines 208-222 leptin Homo sapiens 45-51 26503115-6 2015 Among these were candidate genes associated with development and function of the nervous system, including several genes in the Dopamine decarboxylase (Ddc) cluster involved in catecholamine synthesis. Catecholamines 177-190 Dopa decarboxylase Drosophila melanogaster 128-150 26514659-5 2015 We also studied colocalization of neuropeptide Y (NPY) in norepinephrine and epinephrine-containing neurons as NPY is a common cotransmitter with central and peripheral catecholamines. Catecholamines 169-183 neuropeptide Y Rattus norvegicus 111-114 26497985-5 2015 Upon catecholamine stimulation, eIF3f promotes adrenoceptor activity in vitro, independently of the eIF3f proline- and alanine-rich N-terminal region. Catecholamines 5-18 eukaryotic translation initiation factor 3 subunit F Homo sapiens 32-37 26406372-5 2015 Conversely, genetic ablation of sympathetic inputs onto fat pads blocks leptin-stimulated phosphorylation of hormone-sensitive lipase and consequent lipolysis, as do knockouts of dopamine beta-hydroxylase, an enzyme required for catecholamine synthesis. Catecholamines 229-242 leptin Homo sapiens 72-78 26528222-3 2015 Several findings suggest that catecholamine-related genes may contribute to insight problem solving, among which the catechol-O-methyltransferase (COMT) gene is the most promising candidate. Catecholamines 30-43 catechol-O-methyltransferase Homo sapiens 117-145 26528222-3 2015 Several findings suggest that catecholamine-related genes may contribute to insight problem solving, among which the catechol-O-methyltransferase (COMT) gene is the most promising candidate. Catecholamines 30-43 catechol-O-methyltransferase Homo sapiens 147-151 26187454-5 2015 After 7 days of UCS, mice did not show depressive-like behavior, but the adrenal medullae show increased protein and/or mRNA levels of catecholamine biosynthetic enzymes (TH, DbetaH and PNMT), Neuropeptide Y, the SNARE protein SNAP-25, the catecholamine transporter VMAT2 and the chromaffin progenitor cell markers, Mash1 and Phox2b. Catecholamines 135-148 phenylethanolamine-N-methyltransferase Mus musculus 186-190 26187454-9 2015 Opposite, when mice were submitted to 21 days of UCS, and showed a depressive like behavior, adrenal medullae had lower protein and/or mRNA levels of catecholamine biosynthetic enzymes (TH, DbetaH, PNMT), catecholamine transporters (NET, VMAT1), SNARE proteins (synthaxin1A, SNAP25, VAMP2), catecholamine content (EP, NE), and lower EP serum levels, indicating a reduction in catecholamine synthesis, re-uptake, storage and release. Catecholamines 150-163 phenylethanolamine-N-methyltransferase Mus musculus 198-202 26516580-11 2015 Catecholamine effects in murine ventricles strictly depend on beta 1-AR, even if PDE 4 is blocked. Catecholamines 0-13 adrenergic receptor, beta 1 Mus musculus 62-71 26413230-7 2015 Recent evidence indicates that adrenal GRK2 and betaarrestins can regulate adrenal catecholamine secretion, thereby modulating SNS activity in HF. Catecholamines 83-96 G protein-coupled receptor kinase 2 Homo sapiens 39-43 26276013-1 2015 Tyrosine hydroxylase catalyses the hydroxylation of L-tyrosine to l-DOPA, the rate-limiting step in the synthesis of catecholamines. Catecholamines 117-131 tyrosine hydroxylase Mus musculus 0-20 26276013-6 2015 The mutant tyrosine hydroxylase enzyme was unstable and exhibited deficient stabilization by catecholamines, leading to decline of brain tyrosine hydroxylase-immunoreactivity in the Th knock-in mice. Catecholamines 93-107 tyrosine hydroxylase Mus musculus 11-31 26276013-6 2015 The mutant tyrosine hydroxylase enzyme was unstable and exhibited deficient stabilization by catecholamines, leading to decline of brain tyrosine hydroxylase-immunoreactivity in the Th knock-in mice. Catecholamines 93-107 tyrosine hydroxylase Mus musculus 137-157 26406372-5 2015 Conversely, genetic ablation of sympathetic inputs onto fat pads blocks leptin-stimulated phosphorylation of hormone-sensitive lipase and consequent lipolysis, as do knockouts of dopamine beta-hydroxylase, an enzyme required for catecholamine synthesis. Catecholamines 229-242 dopamine beta-hydroxylase Homo sapiens 179-204 26394059-2 2015 Because STN-DBS is effective in patients with PD whose motor symptoms are dramatically alleviated by L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, the higher preoperative catecholamine levels might be related to the better clinical outcome after surgery. Catecholamines 174-187 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 8-11 26402367-2 2015 Our group recently showed in cultured cells and forebrain slice cultures that this compound can also down regulate expression of Tyrosine hydroxylase (Th), which encodes the rate-limiting enzyme in catecholamine biosynthesis, by stabilizing DNA secondary structures in the Th proximal promoter. Catecholamines 198-211 tyrosine hydroxylase Mus musculus 129-149 26394059-12 2015 The preoperative catecholamine levels had basically negative correlations with postoperative motor scores and quality of life, suggesting that higher preoperative catecholamine levels were related to better outcome after STN-DBS. Catecholamines 17-30 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 221-224 26394059-12 2015 The preoperative catecholamine levels had basically negative correlations with postoperative motor scores and quality of life, suggesting that higher preoperative catecholamine levels were related to better outcome after STN-DBS. Catecholamines 163-176 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 221-224 26173457-0 2015 Pendrin localizes to the adrenal medulla and modulates catecholamine release. Catecholamines 55-68 solute carrier family 26, member 4 Mus musculus 0-7 26173457-12 2015 We conclude that pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release. Catecholamines 93-106 solute carrier family 26, member 4 Mus musculus 17-24 25818930-1 2015 BACKGROUND: Renalase is a protein that can regulate sympathetic nerve activity by metabolizing catecholamines, while redundant catecholamines are thought to contribute to atherosclerosis (As). Catecholamines 95-109 renalase, FAD-dependent amine oxidase Mus musculus 12-20 26284527-3 2015 Tyrosine hydroxylase catalyzes the rate-limiting step in the catecholamine biosynthesis and is linked to several common neurological disorders such as Parkinson"s and schizophrenia. Catecholamines 61-74 tyrosine hydroxylase Homo sapiens 0-20 26004530-8 2015 NT effects are mediated via activation of NT receptors, or produced indirectly via stimulation of release of various endogenous neuromodulators/neurotransmitters such as histamine, catecholamines and prostaglandins. Catecholamines 181-195 neurotensin Homo sapiens 0-2 26153521-9 2015 This suggests that dysfunction of catecholaminergic neurons in the RVLM might account for the reduced sympathetic activity, MBP and plasma catecholamine levels in the early stages of PD. Catecholamines 34-47 myelin basic protein Rattus norvegicus 124-127 25960279-2 2015 We have performed a screening of 10,000 compounds searching for pharmacological chaperones of tyrosine hydroxylase (TH), the tetrahydrobiopterin (BH4)-dependent enzyme that catalyzes the rate-limiting step in the synthesis of catecholamines. Catecholamines 226-240 tyrosine hydroxylase Homo sapiens 94-114 25960279-2 2015 We have performed a screening of 10,000 compounds searching for pharmacological chaperones of tyrosine hydroxylase (TH), the tetrahydrobiopterin (BH4)-dependent enzyme that catalyzes the rate-limiting step in the synthesis of catecholamines. Catecholamines 226-240 tyrosine hydroxylase Homo sapiens 116-118 25818930-2 2015 Catecholamine release can be facilitated by angiotensin (Ang) II by binding to Ang II type 1 (AT1) receptors. Catecholamines 0-13 angiotensin II receptor, type 1a Mus musculus 79-92 25818930-2 2015 Catecholamine release can be facilitated by angiotensin (Ang) II by binding to Ang II type 1 (AT1) receptors. Catecholamines 0-13 angiotensin II receptor, type 1a Mus musculus 94-97 26062632-0 2015 Orexin-A enhances feeding in male rats by activating hindbrain catecholamine neurons. Catecholamines 63-76 hypocretin neuropeptide precursor Rattus norvegicus 0-8 26198390-11 2015 This stress escalation was limited to incident cases with COMT diplotypes coding for low-activity COMT, signifying impaired catabolism of catecholamines. Catecholamines 138-152 catechol-O-methyltransferase Homo sapiens 58-62 26198390-11 2015 This stress escalation was limited to incident cases with COMT diplotypes coding for low-activity COMT, signifying impaired catabolism of catecholamines. Catecholamines 138-152 catechol-O-methyltransferase Homo sapiens 98-102 26346727-4 2015 COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens. Catecholamines 65-78 catechol-O-methyltransferase Homo sapiens 0-4 26092702-3 2015 Results of this study demonstrated that six different secretagogues stimulated the co-release of the neuropeptides Met-enkephalin, galanin, NPY, and VIP with the catecholamines dopamine, norepinephrine, and epinephrine. Catecholamines 162-176 neuropeptide Y Homo sapiens 140-143 26092702-3 2015 Results of this study demonstrated that six different secretagogues stimulated the co-release of the neuropeptides Met-enkephalin, galanin, NPY, and VIP with the catecholamines dopamine, norepinephrine, and epinephrine. Catecholamines 162-176 vasoactive intestinal peptide Homo sapiens 149-152 26062632-2 2015 Orexin fibers and terminals are present in close proximity to hindbrain catecholaminergic neurons, and fourth ventricular (4V) orexin injections that increase food intake also increase c-Fos expression in hindbrain catecholamine neurons, suggesting that orexin neurons may stimulate feeding by activating catecholamine neurons. Catecholamines 72-85 hypocretin neuropeptide precursor Rattus norvegicus 0-6 26062632-2 2015 Orexin fibers and terminals are present in close proximity to hindbrain catecholaminergic neurons, and fourth ventricular (4V) orexin injections that increase food intake also increase c-Fos expression in hindbrain catecholamine neurons, suggesting that orexin neurons may stimulate feeding by activating catecholamine neurons. Catecholamines 215-228 hypocretin neuropeptide precursor Rattus norvegicus 0-6 26062632-2 2015 Orexin fibers and terminals are present in close proximity to hindbrain catecholaminergic neurons, and fourth ventricular (4V) orexin injections that increase food intake also increase c-Fos expression in hindbrain catecholamine neurons, suggesting that orexin neurons may stimulate feeding by activating catecholamine neurons. Catecholamines 215-228 hypocretin neuropeptide precursor Rattus norvegicus 127-133 26062632-2 2015 Orexin fibers and terminals are present in close proximity to hindbrain catecholaminergic neurons, and fourth ventricular (4V) orexin injections that increase food intake also increase c-Fos expression in hindbrain catecholamine neurons, suggesting that orexin neurons may stimulate feeding by activating catecholamine neurons. Catecholamines 215-228 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 185-190 26062632-4 2015 We found that 4V injection of orexin-A (0.5 nmol/rat) produced widespread activation of c-Fos in hindbrain catecholamine cell groups. Catecholamines 107-120 hypocretin neuropeptide precursor Rattus norvegicus 30-38 26062632-4 2015 We found that 4V injection of orexin-A (0.5 nmol/rat) produced widespread activation of c-Fos in hindbrain catecholamine cell groups. Catecholamines 107-120 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 88-93 26062632-6 2015 Then, with the use of the retrogradely transported immunotoxin, anti-DBH conjugated to saporin (DSAP), which targets and destroys DBH-expressing catecholamine neurons, we examined the hypothesis that catecholamine neurons are required for orexin-induced feeding. Catecholamines 200-213 dopamine beta-hydroxylase Rattus norvegicus 69-72 26062632-6 2015 Then, with the use of the retrogradely transported immunotoxin, anti-DBH conjugated to saporin (DSAP), which targets and destroys DBH-expressing catecholamine neurons, we examined the hypothesis that catecholamine neurons are required for orexin-induced feeding. Catecholamines 200-213 dopamine beta-hydroxylase Rattus norvegicus 130-133 26062632-9 2015 These results reveal for the first time that catecholamine neurons are required for feeding induced by injection of orexin-A into either LV or 4V. Catecholamines 45-58 hypocretin neuropeptide precursor Rattus norvegicus 116-124 25392232-1 2015 Chromogranin A (CHGA) is coreleased with catecholamines from secretory vesicles in adrenal medulla and sympathetic axons. Catecholamines 41-55 chromogranin A Mus musculus 0-14 26049000-0 2015 Renalase does not catalyze the oxidation of catecholamines. Catecholamines 44-58 renalase, FAD dependent amine oxidase Homo sapiens 0-8 26049000-1 2015 It is widely accepted that the function of human renalase is to oxidize catecholamines in blood. Catecholamines 72-86 renalase, FAD dependent amine oxidase Homo sapiens 49-57 26049000-8 2015 Using time-dependent spectrophotometry we show that the renalase FAD cofactor spectrum is unresponsive to added catecholamines, that adrenochromes are not observed to accumulate in the presence of renalase and that the kinetics of single turnover reactions with 6-dihydroNAD are unaltered by the addition of catecholamines. Catecholamines 308-322 renalase, FAD dependent amine oxidase Homo sapiens 56-64 25957836-4 2015 Tyrosine hydroxylase (TH) is the major rate-limiting enzyme in catecholamine biosynthesis in response to stress. Catecholamines 63-76 tyrosine hydroxylase Rattus norvegicus 0-20 25957836-4 2015 Tyrosine hydroxylase (TH) is the major rate-limiting enzyme in catecholamine biosynthesis in response to stress. Catecholamines 63-76 tyrosine hydroxylase Rattus norvegicus 22-24 25978516-0 2015 Hindbrain Catecholamine Neurons Activate Orexin Neurons During Systemic Glucoprivation in Male Rats. Catecholamines 10-23 hypocretin neuropeptide precursor Rattus norvegicus 41-47 25978516-3 2015 Orexin neurons, located in the perifornical lateral hypothalamus (PeFLH), are heavily innervated by hindbrain catecholamine neurons, stimulate food intake, and increase arousal and behavioral activation. Catecholamines 110-123 hypocretin neuropeptide precursor Rattus norvegicus 0-6 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 46-59 hypocretin neuropeptide precursor Rattus norvegicus 80-86 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 46-59 dopamine beta-hydroxylase Rattus norvegicus 148-173 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 46-59 dopamine beta-hydroxylase Rattus norvegicus 221-246 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 258-271 hypocretin neuropeptide precursor Rattus norvegicus 80-86 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 258-271 dopamine beta-hydroxylase Rattus norvegicus 148-173 25978516-8 2015 Both responses were eliminated by a lesion of catecholamine neurons innervating orexin neurons using the retrogradely transported immunotoxin, anti-dopamine-beta-hydroxylase saporin, which is specifically internalized by dopamine-beta-hydroxylase-expressing catecholamine neurons. Catecholamines 258-271 dopamine beta-hydroxylase Rattus norvegicus 221-246 25978516-11 2015 In summary, catecholamine neurons are required for the activation of orexin neurons during glucoprivation. Catecholamines 12-25 hypocretin neuropeptide precursor Rattus norvegicus 69-75 25392232-1 2015 Chromogranin A (CHGA) is coreleased with catecholamines from secretory vesicles in adrenal medulla and sympathetic axons. Catecholamines 41-55 chromogranin A Mus musculus 16-20 26092866-0 2015 FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice. Catecholamines 93-106 fibroblast growth factor 21 Mus musculus 0-5 26092866-8 2015 Taken together, our studies demonstrate that FGF21 KO mice are protected from alcohol-induced adipose tissue excess-lipolysis through a mechanism involving systemic catecholamine release. Catecholamines 165-178 fibroblast growth factor 21 Mus musculus 45-50 26095976-0 2015 Enhanced BDNF signalling following chronic hypoxia potentiates catecholamine release from cultured rat adrenal chromaffin cells. Catecholamines 63-76 brain-derived neurotrophic factor Rattus norvegicus 9-13 25904189-16 2015 As an explanation, it was hypothesized that catecholamines, which reduce insulin levels and stimulate melatonin synthesis, control insulin-melatonin interactions. Catecholamines 44-58 insulin Homo sapiens 73-80 25904189-16 2015 As an explanation, it was hypothesized that catecholamines, which reduce insulin levels and stimulate melatonin synthesis, control insulin-melatonin interactions. Catecholamines 44-58 insulin Homo sapiens 131-138 26095976-9 2015 A specific TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), stimulated quantal catecholamine secretion from chronically hypoxic (CHox; 2% O2) AMCs to a greater extent than normoxic (Nox; 21% O2) controls. Catecholamines 76-89 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 11-15 26095976-2 2015 Relative to normoxic controls, activation of the TrkB receptor in chronically hypoxic AMCs led to a marked increase in membrane excitability, intracellular [Ca(2+)], and catecholamine secretion. Catecholamines 170-183 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 49-53 26095976-14 2015 These data demonstrate that during chronic hypoxia, enhancement of BDNF-TrkB signalling increases voltage-dependent Ca(2+) influx and catecholamine secretion in chromaffin cells, and that T-type Ca(2+) channels play a key role in the signalling pathway. Catecholamines 134-147 brain-derived neurotrophic factor Rattus norvegicus 67-71 25956992-0 2015 Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines. Catecholamines 130-144 synuclein alpha Homo sapiens 17-32 26095976-14 2015 These data demonstrate that during chronic hypoxia, enhancement of BDNF-TrkB signalling increases voltage-dependent Ca(2+) influx and catecholamine secretion in chromaffin cells, and that T-type Ca(2+) channels play a key role in the signalling pathway. Catecholamines 134-147 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 72-76 26005840-7 2015 S100A1 interaction with the RyR2 is sufficient to protect against basal and catecholamine-triggered arrhythmic SR Ca(2+) leak in HF, combining antiarrhythmic potency with chronic inotropic actions. Catecholamines 76-89 S100 calcium binding protein A1 Mus musculus 0-6 26005840-7 2015 S100A1 interaction with the RyR2 is sufficient to protect against basal and catecholamine-triggered arrhythmic SR Ca(2+) leak in HF, combining antiarrhythmic potency with chronic inotropic actions. Catecholamines 76-89 ryanodine receptor 2, cardiac Mus musculus 28-32 26221068-1 2015 The beta-2 adrenergic receptor (beta-2 AR) modulates metabolic processes in skeletal muscle, liver, and adipose tissue in response to catecholamine stimulation. Catecholamines 134-147 adrenoceptor beta 2 Homo sapiens 4-30 26221068-1 2015 The beta-2 adrenergic receptor (beta-2 AR) modulates metabolic processes in skeletal muscle, liver, and adipose tissue in response to catecholamine stimulation. Catecholamines 134-147 adrenoceptor beta 2 Homo sapiens 32-41 25867043-5 2015 The expression of dopamine beta-hydroxylase (DBH), the rate-limiting enzyme in regulation of catecholamine synthesis, was induced in colon tissues of mice with restraint stress, indicating the association of catecholamine synthesis with psychological stress. Catecholamines 93-106 dopamine beta hydroxylase Mus musculus 18-43 25867043-5 2015 The expression of dopamine beta-hydroxylase (DBH), the rate-limiting enzyme in regulation of catecholamine synthesis, was induced in colon tissues of mice with restraint stress, indicating the association of catecholamine synthesis with psychological stress. Catecholamines 93-106 dopamine beta hydroxylase Mus musculus 45-48 25867043-5 2015 The expression of dopamine beta-hydroxylase (DBH), the rate-limiting enzyme in regulation of catecholamine synthesis, was induced in colon tissues of mice with restraint stress, indicating the association of catecholamine synthesis with psychological stress. Catecholamines 208-221 dopamine beta hydroxylase Mus musculus 18-43 25867043-5 2015 The expression of dopamine beta-hydroxylase (DBH), the rate-limiting enzyme in regulation of catecholamine synthesis, was induced in colon tissues of mice with restraint stress, indicating the association of catecholamine synthesis with psychological stress. Catecholamines 208-221 dopamine beta hydroxylase Mus musculus 45-48 25466290-2 2015 The catechol-O-methyltransferase (COMT) gene is an interesting candidate, being one of the major mammalian enzymes involved in the catabolism of catecholamines. Catecholamines 145-159 catechol-O-methyltransferase Homo sapiens 4-32 25466290-2 2015 The catechol-O-methyltransferase (COMT) gene is an interesting candidate, being one of the major mammalian enzymes involved in the catabolism of catecholamines. Catecholamines 145-159 catechol-O-methyltransferase Homo sapiens 34-38 25466290-8 2015 Since the COMT enzyme inactivates catecholamines, it was hypothesized that the response to stimulant drugs differs between COMT genotypes. Catecholamines 34-48 catechol-O-methyltransferase Homo sapiens 10-14 25466290-8 2015 Since the COMT enzyme inactivates catecholamines, it was hypothesized that the response to stimulant drugs differs between COMT genotypes. Catecholamines 34-48 catechol-O-methyltransferase Homo sapiens 123-127 26079001-1 2015 Catestatin, a cationic and hydrophobic 21-amino acid fragment of chromogranin A, is known to be a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release. Catecholamines 204-217 chromogranin A Homo sapiens 0-10 26079001-1 2015 Catestatin, a cationic and hydrophobic 21-amino acid fragment of chromogranin A, is known to be a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release. Catecholamines 204-217 chromogranin A Homo sapiens 65-79 25968336-9 2015 Deficiency in UCP1, and accompanying BAT dysfunction, increases cardiomyocyte injury and adverse LV remodeling, and decreases survival in a mouse model of catecholamine-induced cardiomyopathy. Catecholamines 155-168 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 14-18 26309615-3 2015 Renalase is a recently discovered protein that expressed in kidney, heart, liver, and brain that metabolizes catecholamines, regulation of blood pressure in humans and animals. Catecholamines 109-123 renalase, FAD dependent amine oxidase Homo sapiens 0-8 26016690-1 2015 Despite a lack of convincing in vitro evidence and a number of sound refutations, it is widely accepted that renalase is an enzyme unique to animals that catalyzes the oxidative degradation of catecholamines in blood in order to lower vascular tone. Catecholamines 193-207 renalase, FAD dependent amine oxidase Homo sapiens 109-117 26024204-1 2015 Tyrosine hydroxylase is a mononuclear non-heme iron monooxygenase found in the central nervous system that catalyzes the hydroxylation of tyrosine to yield L-3,4-dihydroxyphenylalanine, the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. Catecholamines 232-245 tyrosine hydroxylase Homo sapiens 0-20 25882962-6 2015 Under optimal conditions, 0.1-2 muM dopamine was specifically and 85.4 nA muM(-1) cm(-2) sensitively detected, with no interference from structurally related catecholamines. Catecholamines 158-172 latexin Homo sapiens 32-35 25882962-6 2015 Under optimal conditions, 0.1-2 muM dopamine was specifically and 85.4 nA muM(-1) cm(-2) sensitively detected, with no interference from structurally related catecholamines. Catecholamines 158-172 PWWP domain containing 3A, DNA repair factor Homo sapiens 74-80 26032479-1 2015 The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. Catecholamines 81-94 VGF nerve growth factor inducible Homo sapiens 11-14 26124709-0 2015 Neuroanatomical association of hypothalamic HSD2-containing neurons with ERalpha, catecholamines, or oxytocin: implications for feeding? Catecholamines 82-96 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 44-48 26124709-1 2015 This study used immunohistochemical methods to investigate the possibility that hypothalamic neurons that contain 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) are involved in the control of feeding by rats via neuroanatomical associations with the alpha subtype of estrogen receptor (ERalpha), catecholamines, and/or oxytocin (OT). Catecholamines 300-314 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 114-157 26124709-1 2015 This study used immunohistochemical methods to investigate the possibility that hypothalamic neurons that contain 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) are involved in the control of feeding by rats via neuroanatomical associations with the alpha subtype of estrogen receptor (ERalpha), catecholamines, and/or oxytocin (OT). Catecholamines 300-314 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 159-163 26124709-6 2015 In contrast, there was catecholamine-fiber labeling in the area of HSD2-labeled neurons, and these fibers occasionally were in close apposition to HSD2-labeled neurons. Catecholamines 23-36 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 67-71 26124709-6 2015 In contrast, there was catecholamine-fiber labeling in the area of HSD2-labeled neurons, and these fibers occasionally were in close apposition to HSD2-labeled neurons. Catecholamines 23-36 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 147-151 25809182-1 2015 Recent cardiovascular research showed that, together with beta1- and beta2-adrenergic receptors (ARs), beta3-ARs contribute to the catecholamine (CA)-dependent control of the heart. Catecholamines 131-144 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 103-108 25746453-2 2015 Since catecholamine synthesis depends on the rate-limiting enzyme, tyrosine hydroxylase (TH), TH is thought to play an important role in PFC function. Catecholamines 6-19 tyrosine hydroxylase Rattus norvegicus 67-87 25746453-2 2015 Since catecholamine synthesis depends on the rate-limiting enzyme, tyrosine hydroxylase (TH), TH is thought to play an important role in PFC function. Catecholamines 6-19 tyrosine hydroxylase Rattus norvegicus 89-91 25746453-2 2015 Since catecholamine synthesis depends on the rate-limiting enzyme, tyrosine hydroxylase (TH), TH is thought to play an important role in PFC function. Catecholamines 6-19 tyrosine hydroxylase Rattus norvegicus 94-96 25956449-1 2015 Aromatic L-amino acid decarboxylase (AADC) deficiency is an inborn error of metabolism affecting the biosynthesis of serotonin, dopamine, and catecholamines. Catecholamines 142-156 dopa decarboxylase Homo sapiens 0-35 25781495-2 2015 Renalase, an amine oxidase secreted by the proximal tubule, not only degrades circulating catecholamines but also protects against renal ischaemia reperfusion injury. Catecholamines 90-104 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25956449-1 2015 Aromatic L-amino acid decarboxylase (AADC) deficiency is an inborn error of metabolism affecting the biosynthesis of serotonin, dopamine, and catecholamines. Catecholamines 142-156 dopa decarboxylase Homo sapiens 37-41 27227082-2 2016 A link between thrombomodulin and catecholamines during cold exposure has also been previously suggested. Catecholamines 34-48 thrombomodulin Homo sapiens 15-29 25936509-3 2015 Our in-vitro experiment with synaptosomal/crude mitochondrial fraction from hypothalamus and cortex confirmed that while mono amine oxidase (MAO) is an efficient metabolic enzyme for catecholamines, HA is not significantly affected by its enzymatic action. Catecholamines 183-197 monoamine oxidase A Rattus norvegicus 141-144 25946206-2 2015 Several reports have shown that adrenal glucocorticoids (GC) play an important regulatory role on the genes encoding the main enzymes involved in catecholamine (CAT) synthesis i.e. tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 146-159 tyrosine hydroxylase Homo sapiens 181-201 25946206-2 2015 Several reports have shown that adrenal glucocorticoids (GC) play an important regulatory role on the genes encoding the main enzymes involved in catecholamine (CAT) synthesis i.e. tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 146-159 tyrosine hydroxylase Homo sapiens 203-205 25946206-2 2015 Several reports have shown that adrenal glucocorticoids (GC) play an important regulatory role on the genes encoding the main enzymes involved in catecholamine (CAT) synthesis i.e. tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 146-159 dopamine beta-hydroxylase Homo sapiens 208-233 25946206-2 2015 Several reports have shown that adrenal glucocorticoids (GC) play an important regulatory role on the genes encoding the main enzymes involved in catecholamine (CAT) synthesis i.e. tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 146-159 dopamine beta-hydroxylase Homo sapiens 235-238 25946206-2 2015 Several reports have shown that adrenal glucocorticoids (GC) play an important regulatory role on the genes encoding the main enzymes involved in catecholamine (CAT) synthesis i.e. tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 146-159 phenylethanolamine N-methyltransferase Homo sapiens 244-282 25946206-2 2015 Several reports have shown that adrenal glucocorticoids (GC) play an important regulatory role on the genes encoding the main enzymes involved in catecholamine (CAT) synthesis i.e. tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 146-159 phenylethanolamine N-methyltransferase Homo sapiens 284-288 27227082-10 2016 Median concentrations of plasma noradrenaline and urinary adrenaline were higher after exposure to +10 C than to +30 C. Thus, further evidence of the association between thrombomodulin and catecholamines was gained in a physiologically relevant setting in humans. Catecholamines 189-203 thrombomodulin Homo sapiens 170-184 25591042-2 2015 The release of endogenous catecholamines associated with shock or the administration of beta2-adrenergic receptor (beta2AR) agonists enhances AFC via a 3"-5"-cyclic adenosine monophosphate-dependent mechanism. Catecholamines 26-40 adrenoceptor beta 2 Homo sapiens 88-113 25591042-2 2015 The release of endogenous catecholamines associated with shock or the administration of beta2-adrenergic receptor (beta2AR) agonists enhances AFC via a 3"-5"-cyclic adenosine monophosphate-dependent mechanism. Catecholamines 26-40 adrenoceptor beta 2 Homo sapiens 115-122 25740694-2 2015 A widely accepted model is that insulin antagonises catecholamine-dependent lipolysis through phosphorylation and activation of cAMP phosphodiesterase 3B (PDE3B) by the serine-threonine protein kinase Akt (protein kinase B). Catecholamines 52-65 phosphodiesterase 3B, cGMP-inhibited Mus musculus 155-160 25740694-2 2015 A widely accepted model is that insulin antagonises catecholamine-dependent lipolysis through phosphorylation and activation of cAMP phosphodiesterase 3B (PDE3B) by the serine-threonine protein kinase Akt (protein kinase B). Catecholamines 52-65 thymoma viral proto-oncogene 1 Mus musculus 201-204 25740694-7 2015 In support of these in vivo observations, insulin antagonised catecholamine-induced lipolysis in primary brown fat adipocytes from Akt2-deficient mice. Catecholamines 62-75 thymoma viral proto-oncogene 2 Mus musculus 131-135 25565647-11 2015 Plasma I-FABP was higher among patients receiving catecholamine than in controls. Catecholamines 50-63 fatty acid binding protein 2 Homo sapiens 7-13 25565647-12 2015 Among patients receiving catecholamines, a dose of 0.48 gamma kg min or more at ICU admission was associated with a higher I-FABP concentration. Catecholamines 25-39 fatty acid binding protein 2 Homo sapiens 123-129 25565647-14 2015 Catecholamine use is associated with I-FABP elevation in critically ill patients. Catecholamines 0-13 fatty acid binding protein 2 Homo sapiens 37-43 26451286-4 2015 While the gene expression profile and basal bioenergetics of 3T3-L1 adipocytes was typical of white adipocytes, they responded acutely to catecholamines by increasing oxygen consumption in an UCP1-dependent manner, and by increasing the expression of genes enriched in brown but not beige adipocytes. Catecholamines 138-152 uncoupling protein 1 Homo sapiens 192-196 25922519-0 2015 IRBIT regulates CaMKIIalpha activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Catecholamines 56-69 S-adenosylhomocysteine hydrolase-like 1 Mus musculus 0-5 25922519-5 2015 In addition, we show that mice lacking IRBIT present with elevated catecholamine levels, increased locomotor activity, and social abnormalities. Catecholamines 67-80 S-adenosylhomocysteine hydrolase-like 1 Mus musculus 39-44 25922519-7 2015 We concluded that IRBIT suppresses CaMKIIalpha activity and contributes to catecholamine homeostasis through TH phosphorylation. Catecholamines 75-88 S-adenosylhomocysteine hydrolase-like 1 Mus musculus 18-23 26222297-7 2015 Along with glucocorticoids and catecholamines, BDNF seems to be important in understanding stress physiology. Catecholamines 31-45 brain-derived neurotrophic factor Rattus norvegicus 47-51 25897233-1 2015 PURPOSE: This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene. Catecholamines 78-91 catechol-O-methyltransferase Homo sapiens 186-214 25897233-14 2015 CONCLUSION: The relationship among the COMT Val158Met polymorphism, plasma levels of catecholamine metabolites, and responses to duloxetine is complex. Catecholamines 85-98 catechol-O-methyltransferase Homo sapiens 39-43 25903953-3 2015 We analyzed the mRNA levels of catecholamine-synthesizing enzymes: tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AAAD), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in adrenal glands of 18 pigs with chronic systolic non-ischaemic HF (tachycardia-induced cardiomyopathy due to right ventricle pacing) and 6 sham-operated controls. Catecholamines 31-44 TH Sus scrofa 89-91 25903953-3 2015 We analyzed the mRNA levels of catecholamine-synthesizing enzymes: tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AAAD), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in adrenal glands of 18 pigs with chronic systolic non-ischaemic HF (tachycardia-induced cardiomyopathy due to right ventricle pacing) and 6 sham-operated controls. Catecholamines 31-44 dopa decarboxylase Sus scrofa 94-129 25903953-3 2015 We analyzed the mRNA levels of catecholamine-synthesizing enzymes: tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AAAD), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in adrenal glands of 18 pigs with chronic systolic non-ischaemic HF (tachycardia-induced cardiomyopathy due to right ventricle pacing) and 6 sham-operated controls. Catecholamines 31-44 dopamine beta-hydroxylase Sus scrofa 165-168 25903953-3 2015 We analyzed the mRNA levels of catecholamine-synthesizing enzymes: tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AAAD), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in adrenal glands of 18 pigs with chronic systolic non-ischaemic HF (tachycardia-induced cardiomyopathy due to right ventricle pacing) and 6 sham-operated controls. Catecholamines 31-44 phenylethanolamine N-methyltransferase Sus scrofa 174-212 25903953-3 2015 We analyzed the mRNA levels of catecholamine-synthesizing enzymes: tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AAAD), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in adrenal glands of 18 pigs with chronic systolic non-ischaemic HF (tachycardia-induced cardiomyopathy due to right ventricle pacing) and 6 sham-operated controls. Catecholamines 31-44 phenylethanolamine N-methyltransferase Sus scrofa 214-218 25855187-6 2015 Here amperometry and conductance measurements were performed to probe the function of the syb2 TMD in fusion pores formed during catecholamine exocytosis in mouse chromaffin cells. Catecholamines 129-142 vesicle-associated membrane protein 2 Mus musculus 90-94 25848973-1 2015 Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Catecholamines 55-68 chromogranin A Homo sapiens 0-10 25903953-3 2015 We analyzed the mRNA levels of catecholamine-synthesizing enzymes: tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AAAD), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in adrenal glands of 18 pigs with chronic systolic non-ischaemic HF (tachycardia-induced cardiomyopathy due to right ventricle pacing) and 6 sham-operated controls. Catecholamines 31-44 TH Sus scrofa 67-87 25323625-0 2015 The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion. Catecholamines 177-190 solute carrier family 18 member A2 Homo sapiens 4-10 25543320-7 2015 Catecholamine concentrations in urine correlated significantly with TM concentration in urine and TM mRNA levels in all groups excluding CVD deaths. Catecholamines 0-13 thrombomodulin Homo sapiens 68-70 25589013-9 2015 Prorenin activation of the (P)RR increased phosphorylation of extracellular signal-regulated kinase 1/2 and tyrosine hydroxylase at Ser(31), likely increasing its enzymatic activity and catecholamine biosynthesis. Catecholamines 186-199 tyrosine hydroxylase Rattus norvegicus 62-128 25543320-7 2015 Catecholamine concentrations in urine correlated significantly with TM concentration in urine and TM mRNA levels in all groups excluding CVD deaths. Catecholamines 0-13 thrombomodulin Homo sapiens 98-100 25738355-3 2015 In vitro, MCP1 was significantly increased after catecholamine exposure, which was mediated by cAMP and PKA. Catecholamines 49-62 chemokine (C-C motif) ligand 2 Mus musculus 10-14 25416155-2 2015 It thereby amplifies PKA signaling, which, in the heart, mediates both beneficial (acute) and adverse (chronic) effects of catecholamines. Catecholamines 123-137 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 21-24 25416155-3 2015 Genetic deletion of I-1 was associated with protection against catecholamine toxicity, making the PP1c-I-1(P) complex a potential therapeutic target for chronic heart disease. Catecholamines 63-76 protein phosphatase 1, regulatory (inhibitor) subunit 1A Rattus norvegicus 20-23 25416155-9 2015 Incubation of neonatal rat cardiac myocytes with a poly-Arg-modified SPRKIQFTV (10 muM) reduced catecholamine-induced phosphorylation of phospholamban, a well-known PKA downstream target sensitive to PP1c. Catecholamines 96-109 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 165-168 25723162-0 2015 Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Catecholamines 77-90 CREB-regulated transcription coactivator 1 homolog Caenorhabditis elegans 9-15 25643985-3 2015 Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. Catecholamines 130-143 aquaporin 7 Mus musculus 19-23 25723162-5 2015 Neuronal CRTC-1/CREB regulates peripheral metabolism antagonistically with the functional PPARalpha ortholog, NHR-49, drives mitochondrial fragmentation in distal tissues, and suppresses the effects of AMPK on systemic mitochondrial metabolism and longevity via a cell-nonautonomous catecholamine signal. Catecholamines 283-296 CREB-regulated transcription coactivator 1 homolog Caenorhabditis elegans 9-15 25723162-5 2015 Neuronal CRTC-1/CREB regulates peripheral metabolism antagonistically with the functional PPARalpha ortholog, NHR-49, drives mitochondrial fragmentation in distal tissues, and suppresses the effects of AMPK on systemic mitochondrial metabolism and longevity via a cell-nonautonomous catecholamine signal. Catecholamines 283-296 NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49 Caenorhabditis elegans 110-116 25620605-3 2015 Reducing Nav1.3/Nav1.7 availability by tetrodotoxin or by sustained depolarization near rest leads to a switch from tonic to burst-firing patterns that give rise to elevated Ca(2+)-influx and increased catecholamine release. Catecholamines 202-215 sodium channel, voltage-gated, type III, alpha Mus musculus 9-15 25710381-2 2015 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamines biosynthesis, is involved in hypertension development. Catecholamines 55-69 tyrosine hydroxylase Rattus norvegicus 0-20 25710381-2 2015 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamines biosynthesis, is involved in hypertension development. Catecholamines 55-69 tyrosine hydroxylase Rattus norvegicus 22-24 25713330-1 2015 Acute metabolic stress such as insulin-induced hypoglycemia triggers a counterregulatory response during which the release of catecholamines (epinephrine), the activation of tyrosine hydroxylase (TH) enzyme and subsequent compensatory catecholamine biosynthesis occur in the adrenal medulla. Catecholamines 126-139 tyrosine hydroxylase Rattus norvegicus 174-194 25713330-1 2015 Acute metabolic stress such as insulin-induced hypoglycemia triggers a counterregulatory response during which the release of catecholamines (epinephrine), the activation of tyrosine hydroxylase (TH) enzyme and subsequent compensatory catecholamine biosynthesis occur in the adrenal medulla. Catecholamines 126-139 tyrosine hydroxylase Rattus norvegicus 196-198 25620605-3 2015 Reducing Nav1.3/Nav1.7 availability by tetrodotoxin or by sustained depolarization near rest leads to a switch from tonic to burst-firing patterns that give rise to elevated Ca(2+)-influx and increased catecholamine release. Catecholamines 202-215 sodium channel, voltage-gated, type IX, alpha Mus musculus 16-22 25620605-17 2015 Thus, Nav1.3/Nav1.7 channel availability sets the AP shape, burst-firing initiation and regulates catecholamine secretion in MCCs. Catecholamines 98-111 sodium channel, voltage-gated, type III, alpha Mus musculus 6-12 25620605-17 2015 Thus, Nav1.3/Nav1.7 channel availability sets the AP shape, burst-firing initiation and regulates catecholamine secretion in MCCs. Catecholamines 98-111 sodium channel, voltage-gated, type IX, alpha Mus musculus 13-19 26266996-4 2015 While many of these have focused in the past on markers related to neurotransmitter systems such as catecholamines (catechol-O-methyltransferase (COMT)) and serotonin, novel target genes have recently emerged. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 116-144 25541224-6 2015 However, under acidemic conditions and high catecholamine levels and/or absence of gasping, vasopressin should be administered instead. Catecholamines 44-57 arginine vasopressin Homo sapiens 92-103 25320962-2 2015 In particular, the catechol-O-methyltransferase (COMT) gene, located on chromosome 22q11.2, regulates catecholamine signaling in the prefrontal cortex and is implicated in anxiety, pain, and stress responsivity. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 19-47 25320962-2 2015 In particular, the catechol-O-methyltransferase (COMT) gene, located on chromosome 22q11.2, regulates catecholamine signaling in the prefrontal cortex and is implicated in anxiety, pain, and stress responsivity. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 49-53 26266996-4 2015 While many of these have focused in the past on markers related to neurotransmitter systems such as catecholamines (catechol-O-methyltransferase (COMT)) and serotonin, novel target genes have recently emerged. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 146-150 24590362-0 2015 Serum renalase is related to catecholamine levels and renal function. Catecholamines 29-42 renalase, FAD dependent amine oxidase Homo sapiens 6-14 25497549-1 2015 AIMS: Renalase, an enzyme that can metabolize catecholamine, was recently reported to attenuate the ischaemia/reperfusion (I/R)-induced cardiac injury. Catecholamines 46-59 renalase, FAD-dependent amine oxidase Mus musculus 6-14 25497549-9 2015 In addition, the levels of norepinephrine in serum as well as nicotinamide adenine dinucleotide (NAD(+)) and ATP in myocardium were determined, which implied that cardiac protection of renalase against I/R may be related, at least in part, to its metabolism of catecholamine and regulation of energy. Catecholamines 261-274 renalase, FAD-dependent amine oxidase Mus musculus 185-193 24590362-1 2015 BACKGROUND: Renalase is a kidney-origin monoamine oxidase which can degrade catecholamines and regulate blood pressure and cardiovascular function. Catecholamines 76-90 renalase, FAD dependent amine oxidase Homo sapiens 12-20 24590362-5 2015 Renalase levels were linearly correlated with catecholamine levels (R (2) = 0.817; P < 0.01). Catecholamines 46-59 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25545706-2 2015 In the failing heart, elevated beta-adrenergic receptor (beta-AR) activation by catecholamines causes G-protein-coupled receptor kinase-2 (GRK2) upregulation which is responsible for beta-AR signalling dysfunction. Catecholamines 80-94 G protein-coupled receptor kinase 2 Homo sapiens 102-137 25545706-2 2015 In the failing heart, elevated beta-adrenergic receptor (beta-AR) activation by catecholamines causes G-protein-coupled receptor kinase-2 (GRK2) upregulation which is responsible for beta-AR signalling dysfunction. Catecholamines 80-94 G protein-coupled receptor kinase 2 Homo sapiens 139-143 26012107-5 2015 In realization of calorigenic effect of catecholamines during long-term cold exposures it is participated following signaling pathway: catecholamines --> beta-adrenergic receptors (AR) --> adenylyl cyclase --> cAMP --> protein kinase A --> p38 kinase --> transcription factors --> enhancement of UCP expression. Catecholamines 40-54 uncoupling protein 1 Homo sapiens 317-320 25440643-14 2015 CONCLUSIONS: Vasopressin infusion has been used to treat catecholamine-unresponsive shock. Catecholamines 57-70 arginine vasopressin Homo sapiens 13-24 25555360-9 2015 Finally, catechol-O-methyltransferase (COMT) is important for regulation of catecholamine levels, which play a role in fear memory formation and extinction. Catecholamines 76-89 catechol-O-methyltransferase Mus musculus 9-37 25555360-9 2015 Finally, catechol-O-methyltransferase (COMT) is important for regulation of catecholamine levels, which play a role in fear memory formation and extinction. Catecholamines 76-89 catechol-O-methyltransferase Mus musculus 39-43 25555360-10 2015 COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice. Catecholamines 104-117 catechol-O-methyltransferase Mus musculus 0-4 26103718-2 2015 HSL is regulated mainly by catecholamine, including adrenalin. Catecholamines 27-40 lipase, hormone sensitive Mus musculus 0-3 26012107-5 2015 In realization of calorigenic effect of catecholamines during long-term cold exposures it is participated following signaling pathway: catecholamines --> beta-adrenergic receptors (AR) --> adenylyl cyclase --> cAMP --> protein kinase A --> p38 kinase --> transcription factors --> enhancement of UCP expression. Catecholamines 135-149 uncoupling protein 1 Homo sapiens 317-320 26012107-6 2015 At acute cold exposure it was realized catecholamines --> beta-AR --> adenylyl cyclase --> cAMP --> protein kinase A --> hormone sensitive lipase --> free fatty acids --> UCP --> uncoupling oxidative phosphorylation. Catecholamines 39-53 uncoupling protein 1 Homo sapiens 192-195 25297920-1 2015 Half a century after the discovery of chromogranin A as a secreted product of the catecholamine storage granules in the bovine adrenal medulla, the physiological role for the circulating pool of this protein has been recently coined, namely as an important player in vascular homeostasis. Catecholamines 82-95 chromogranin A Bos taurus 38-52 25636335-2 2015 Chromogranin A (CgA) is a neuroendocrine secretory protein that is co-released with catecholamines from the adrenal medulla and sympathetic nerve endings. Catecholamines 84-98 chromogranin-A Canis lupus familiaris 0-14 25636335-2 2015 Chromogranin A (CgA) is a neuroendocrine secretory protein that is co-released with catecholamines from the adrenal medulla and sympathetic nerve endings. Catecholamines 84-98 chromogranin-A Canis lupus familiaris 16-19 25531177-2 2015 There remains a prevailing belief that renalase functions as a hormone, imparting an influence on vascular tone and heart rate by oxidizing circulating catecholamines, chiefly epinephrine. Catecholamines 152-166 renalase, FAD dependent amine oxidase Homo sapiens 39-47 25411385-1 2015 Renalase is a recently identified FAD/NADH-dependent amine oxidase mainly expressed in kidney that is secreted into blood and urine where it was suggested to metabolize catecholamines. Catecholamines 169-183 renalase, FAD-dependent amine oxidase Mus musculus 0-8 25411385-2 2015 The present study evaluated central and peripheral dopaminergic activities in the renalase knockout (KO) mouse model and examined the changes induced by recombinant renalase (RR) administration on plasma and urine catecholamine levels. Catecholamines 214-227 renalase, FAD-dependent amine oxidase Mus musculus 165-173 26630958-3 2015 COMT is involved in catabolizing catecholamines such as dopamine. Catecholamines 33-47 catechol-O-methyltransferase Homo sapiens 0-4 25966692-0 2015 Cav1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells. Catecholamines 61-74 calcium channel, voltage-dependent, L type, alpha 1D subunit Mus musculus 0-6 25966692-3 2015 In the chromaffin cells (CCs) of the adrenal medulla, Cav1.3 is highly expressed and is shown to support most of the pacemaking current that sustains action potential (AP) firings and part of the catecholamine secretion. Catecholamines 196-209 calcium channel, voltage-dependent, L type, alpha 1D subunit Mus musculus 54-60 25386823-1 2015 Catestatin (CST), the Chromogranin A (CgA)-derived cationic and hydrophobic peptide, firstly recognized as an endogenous inhibitor of catecholamine secretion, functions as a physiological brake of the adreno-sympathetic-chromaffin system. Catecholamines 134-147 chromogranin A Mus musculus 22-36 25386823-1 2015 Catestatin (CST), the Chromogranin A (CgA)-derived cationic and hydrophobic peptide, firstly recognized as an endogenous inhibitor of catecholamine secretion, functions as a physiological brake of the adreno-sympathetic-chromaffin system. Catecholamines 134-147 chromogranin A Mus musculus 38-41 26457501-0 2015 Catecholamine crisis as a first manifestation of familial bilateral pheochromocytoma caused by RET proto-oncogene mutation in codon C 634R. Catecholamines 0-13 ret proto-oncogene Homo sapiens 95-98 26211667-3 2015 While CST is a potent inhibitor of catecholamine secretion, PST is a potent physiological inhibitor of glucose-induced insulin secretion. Catecholamines 35-48 chromogranin A Homo sapiens 6-9 26457501-3 2015 The authors present a case study of three family members with bilateral pheochromocytoma in the course of MEN 2A, a catecholamine crisis being the first manifestation of the syndrome in one of them. Catecholamines 116-129 ret proto-oncogene Homo sapiens 106-112 25600541-2 2015 It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 143-147 25673489-0 2015 Rapid determination of catecholamines in urine samples by nonaqueous microchip electrophoresis with LIF detection. Catecholamines 23-37 LIF interleukin 6 family cytokine Homo sapiens 100-103 25304347-4 2015 To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes. Catecholamines 89-103 OCTN3 Homo sapiens 146-174 25304347-4 2015 To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes. Catecholamines 89-103 OCTN3 Homo sapiens 176-180 25304347-4 2015 To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes. Catecholamines 89-103 C-C motif chemokine ligand 21 Homo sapiens 199-202 24794824-5 2015 DHEA/S stimulates neurite growth, neurogenesis and neuronal survival, apoptosis, catecholamine synthesis and secretion. Catecholamines 81-94 sulfotransferase family 2A member 1 Homo sapiens 0-6 25404345-1 2014 In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). Catecholamines 34-47 cAMP responsive element binding protein 1 Homo sapiens 138-181 24800755-9 2015 CONCLUSIONS: These results imply that lymphocyte-derived CAs promote polarization of differentiation and function towards Th2 cells and that this effect is mediated by alpha1-AR and beta2-AR. Catecholamines 57-60 adrenergic receptor, beta 2 Mus musculus 182-190 26817339-5 2015 There are some factors enhancing the release of renalase: rising catecholamines levels in the circulation and increase in blood pressure. Catecholamines 65-79 renalase, FAD dependent amine oxidase Homo sapiens 48-56 26817339-9 2015 Stimulation of catecholamines degradation, perhaps using recombinant renalase or its analogues, is a new concept in the treatment of hypertension in CKD. Catecholamines 15-29 renalase, FAD dependent amine oxidase Homo sapiens 69-77 25422441-0 2014 Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes. Catecholamines 0-13 mechanistic target of rapamycin kinase Homo sapiens 39-43 25522424-8 2014 The plasma leptin levels were higher under catecholamine depletion compared with placebo in the whole sample (treatment effect; P=.0004). Catecholamines 43-56 leptin Homo sapiens 11-17 25522424-9 2014 CONCLUSIONS: This study reports on preliminary findings that suggest a catecholamine-dependent association of plasma BDNF and reward learning in subjects with remitted bulimia nervosa and controls. Catecholamines 71-84 brain derived neurotrophic factor Homo sapiens 117-121 25522424-11 2014 However, leptin levels were sensitive to a depletion of catecholamine stores in both remitted bulimia nervosa and controls. Catecholamines 56-69 leptin Homo sapiens 9-15 25677368-4 2015 Therefore, our aim was to demonstrate the presence of catecholamine-synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) in HNPGL tissue. Catecholamines 54-67 tyrosine hydroxylase Homo sapiens 95-115 25677368-4 2015 Therefore, our aim was to demonstrate the presence of catecholamine-synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) in HNPGL tissue. Catecholamines 54-67 tyrosine hydroxylase Homo sapiens 117-119 25677368-4 2015 Therefore, our aim was to demonstrate the presence of catecholamine-synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) in HNPGL tissue. Catecholamines 54-67 dopa decarboxylase Homo sapiens 122-157 25677368-4 2015 Therefore, our aim was to demonstrate the presence of catecholamine-synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) in HNPGL tissue. Catecholamines 54-67 dopa decarboxylase Homo sapiens 159-163 25677368-4 2015 Therefore, our aim was to demonstrate the presence of catecholamine-synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) in HNPGL tissue. Catecholamines 54-67 dopamine beta-hydroxylase Homo sapiens 169-194 25677368-4 2015 Therefore, our aim was to demonstrate the presence of catecholamine-synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) in HNPGL tissue. Catecholamines 54-67 dopamine beta-hydroxylase Homo sapiens 196-199 25677368-14 2015 CONCLUSIONS: Catecholamine-synthesizing enzymes, in particular AADC, are expressed in the majority of HNPGL tissues. Catecholamines 13-26 dopa decarboxylase Homo sapiens 63-67 25194126-8 2015 However, NET expression was significantly lower in catecholamine-depleted rats compared to the controls. Catecholamines 51-64 solute carrier family 6 member 2 Rattus norvegicus 9-12 25404345-1 2014 In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). Catecholamines 34-47 cAMP responsive element binding protein 1 Homo sapiens 183-187 25132576-0 2014 Associations between salivary alpha-amylase and catecholamines--a multilevel modeling approach. Catecholamines 48-62 amylase alpha 1A Homo sapiens 21-43 25132576-3 2014 We therefore assumed that time-sensitive statistical analyses might help identifying possible associations of sAA and catecholamines. Catecholamines 118-132 amylase alpha 1A Homo sapiens 110-113 25132576-8 2014 Over the time course, sAA was significantly associated with the catecholamines (Study 1: R(2)=.43, Study 2: R(2)=.09) and both served as mediators of sAA increases. Catecholamines 64-78 amylase alpha 1A Homo sapiens 22-25 25136978-1 2014 Catestatin (CST) was first discovered as a potent non-competitive and reversible inhibitor of catecholamine secretion. Catecholamines 94-107 chromogranin A Homo sapiens 0-10 25136978-1 2014 Catestatin (CST) was first discovered as a potent non-competitive and reversible inhibitor of catecholamine secretion. Catecholamines 94-107 chromogranin A Homo sapiens 12-15 25149042-7 2014 Changes in response to ANG II following pre-treatment with phentolamine (alpha-adrenergic antagonist) indicated a portion of the ANG II response was due to circulating catecholamines in captopril-treated embryos. Catecholamines 168-182 ribonuclease A family member k6 Gallus gallus 23-26 25052258-1 2014 BACKGROUND AND PURPOSE: CGP 12177 not only inhibits agonist effects mediated through the catecholamine site of the beta1 -adrenoceptor with high affinity, but also exhibits agonist effects of its own at higher concentrations through a secondary, low-affinity beta1 -adrenoceptor site or conformation. Catecholamines 89-102 adrenoceptor beta 1 Homo sapiens 115-134 25052258-1 2014 BACKGROUND AND PURPOSE: CGP 12177 not only inhibits agonist effects mediated through the catecholamine site of the beta1 -adrenoceptor with high affinity, but also exhibits agonist effects of its own at higher concentrations through a secondary, low-affinity beta1 -adrenoceptor site or conformation. Catecholamines 89-102 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 115-120 25149042-7 2014 Changes in response to ANG II following pre-treatment with phentolamine (alpha-adrenergic antagonist) indicated a portion of the ANG II response was due to circulating catecholamines in captopril-treated embryos. Catecholamines 168-182 ribonuclease A family member k6 Gallus gallus 129-132 24986918-0 2014 The catecholamine biosynthetic enzyme dopamine beta-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter. Catecholamines 4-17 dopamine beta-hydroxylase Homo sapiens 38-63 24986918-0 2014 The catecholamine biosynthetic enzyme dopamine beta-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter. Catecholamines 4-17 dopamine beta-hydroxylase Homo sapiens 65-68 24986918-11 2014 We conclude that three common SNPs in the DBH promoter act additively to control phenotypic variation in DBH levels, and that two additional novel loci (SARDH and LOC338797) may also contribute to the expression of this catecholamine biosynthetic trait. Catecholamines 220-233 dopamine beta-hydroxylase Homo sapiens 42-45 24986918-11 2014 We conclude that three common SNPs in the DBH promoter act additively to control phenotypic variation in DBH levels, and that two additional novel loci (SARDH and LOC338797) may also contribute to the expression of this catecholamine biosynthetic trait. Catecholamines 220-233 dopamine beta-hydroxylase Homo sapiens 105-108 24986918-11 2014 We conclude that three common SNPs in the DBH promoter act additively to control phenotypic variation in DBH levels, and that two additional novel loci (SARDH and LOC338797) may also contribute to the expression of this catecholamine biosynthetic trait. Catecholamines 220-233 sarcosine dehydrogenase Homo sapiens 153-158 25541617-1 2014 Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare, autosomal-recessive neurological disorder caused by mutations in the DDC gene that leads to an inability to synthesize catecholamines and serotonin. Catecholamines 184-198 dopa decarboxylase Homo sapiens 0-35 25295465-8 2014 Interestingly, renalase promoter activity was augmented by nicotine and catecholamines; while Sp1 and STAT3 synergistically activated the nicotine-induced effect, Sp1 appeared to enhance epinephrine-evoked renalase transcription. Catecholamines 72-86 renalase, FAD dependent amine oxidase Homo sapiens 15-23 25230286-2 2014 To find out if these cells express tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine synthesis pathway, we performed immunohistochemistry in the rat cortex following intraventricular injection of 6-OHDA. Catecholamines 94-107 tyrosine hydroxylase Rattus norvegicus 35-55 25331291-7 2014 These results demonstrated an essential role of VNUT in vesicular storage and release of ATP in neuroendocrine cells in vivo and suggest that vesicular ATP and/or its degradation products act as feedback regulators in catecholamine and insulin secretion, thereby regulating blood glucose homeostasis. Catecholamines 218-231 solute carrier family 17, member 9 Mus musculus 48-52 25109347-9 2014 Hence, cellular and soluble levels of thrombomodulin are modified by cold stress in healthy rats, possibly via catecholamines and HSF1. Catecholamines 111-125 thrombomodulin Rattus norvegicus 38-52 25077558-3 2014 In this study, we set out to assess the role of CgA in the accumulation and exocytosis of CAs in cells when the levels of CgA and CA are manipulated. Catecholamines 90-93 chromogranin A Rattus norvegicus 48-51 25077558-3 2014 In this study, we set out to assess the role of CgA in the accumulation and exocytosis of CAs in cells when the levels of CgA and CA are manipulated. Catecholamines 90-93 chromogranin A Rattus norvegicus 122-125 25084049-9 2014 The present evidence for discriminative reactivity of AMPK-expressing medullary catecholamine neurons to the screened energy substrate lactate implies that that lactoprivation is selectively signaled to the hypothalamus by A2 noradrenergic and C1 adrenergic cells. Catecholamines 80-93 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 54-58 25286986-2 2014 Angiotensin II (ATII) may prove useful in patients who remain hypotensive despite catecholamine and vasopressin therapy. Catecholamines 82-95 angiotensinogen Homo sapiens 0-14 24882215-5 2014 In addition, this catecholamine reduced Treg-related cytokines (IL-10 and TGF-beta) release by activated CD4(+) T cells. Catecholamines 18-31 interleukin 10 Homo sapiens 64-69 24882215-5 2014 In addition, this catecholamine reduced Treg-related cytokines (IL-10 and TGF-beta) release by activated CD4(+) T cells. Catecholamines 18-31 CD4 molecule Homo sapiens 105-108 25083741-10 2014 Interestingly, NE"s growth-suppressive effect is modulated by endogenously expressed catecholamine-inactivating enzymes (catechol-O-methyltransferase and l-monoamine oxidase) and is dominant over the growth-promoting effects of PDE inhibitors. Catecholamines 85-98 catechol-O-methyltransferase Homo sapiens 121-149 25186490-1 2014 The alpha2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. Catecholamines 90-103 adrenergic receptor, alpha 2a Mus musculus 4-24 24929186-4 2014 In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR. Catecholamines 163-176 adrenoceptor beta 2 Homo sapiens 185-210 25108642-1 2014 Catechol-O-methyltransferase (COMT) is one of the cardinal enzymes that metabolize dopamine and other catecholamine neurotransmitters in the central and peripheral nervous system. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 0-28 25108642-1 2014 Catechol-O-methyltransferase (COMT) is one of the cardinal enzymes that metabolize dopamine and other catecholamine neurotransmitters in the central and peripheral nervous system. Catecholamines 102-115 catechol-O-methyltransferase Homo sapiens 30-34 25380930-1 2014 INTRODUCTION: Renalase may degrade catecholamines and regulate sympathetic tone and blood pressure. Catecholamines 35-49 renalase, FAD dependent amine oxidase Homo sapiens 14-22 25352764-0 2014 Inhibitory effects of ginsenoside-rb2 on nicotinic stimulation-evoked catecholamine secretion. Catecholamines 70-83 RB transcriptional corepressor like 2 Rattus norvegicus 34-37 25352764-1 2014 The aim of the present study was to investigate whether ginsenoside-Rb2 (Rb2) can affect the secretion of catecholamines (CA) in the perfused model of the rat adrenal medulla. Catecholamines 106-120 RB transcriptional corepressor like 2 Rattus norvegicus 68-71 25237296-0 2014 Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells. Catecholamines 53-66 pannexin 1 Homo sapiens 0-10 25237296-5 2014 Here, we show that Panx1 is expressed in the adrenal gland where it plays a role by regulating the release of catecholamines. Catecholamines 110-124 pannexin 1 Homo sapiens 19-24 24929186-4 2014 In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR. Catecholamines 163-176 adrenoceptor beta 2 Homo sapiens 212-220 24929186-4 2014 In this study, we investigated the effects of quercetin-3-O-glucuronide (Q3G), a circulating metabolite of quercetin, which is a type of natural flavonoid, on the catecholamine-induced beta2-adrenergic receptor (beta2-AR)-mediated response in MDA-MB-231 human breast cancer cells expressing beta2-AR. Catecholamines 163-176 adrenoceptor beta 2 Homo sapiens 291-299 24863408-0 2014 Enhanced transglutaminase 2 expression in response to stress-related catecholamines in macrophages. Catecholamines 69-83 transglutaminase 2, C polypeptide Mus musculus 9-27 24844469-11 2014 Moreover, TGF-beta1, IGF-1, HA and PIP production and the cell migration of human skin fibroblasts are possibly modulated by natural catecholamines produced by the endocrine system or sympathetic innervation, which could directly or indirectly participate in cytokine secretion, fibroblast migration and matrix production of wound healing in the skin. Catecholamines 133-147 transforming growth factor beta 1 Homo sapiens 10-19 24844469-11 2014 Moreover, TGF-beta1, IGF-1, HA and PIP production and the cell migration of human skin fibroblasts are possibly modulated by natural catecholamines produced by the endocrine system or sympathetic innervation, which could directly or indirectly participate in cytokine secretion, fibroblast migration and matrix production of wound healing in the skin. Catecholamines 133-147 insulin like growth factor 1 Homo sapiens 21-26 25035343-1 2014 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. Catecholamines 64-77 catechol-O-methyltransferase Homo sapiens 11-39 25035343-1 2014 OBJECTIVE: Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. Catecholamines 64-77 catechol-O-methyltransferase Homo sapiens 41-45 24995679-3 2014 PACAP appears to be associated with the "fight-or-flight" response to emergency partly through its effect on adrenal production of cortisol and catecholamines. Catecholamines 144-158 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 24863408-9 2014 Because stress events activate the sympathetic nervous system and result in secretion of the catecholamines, adrenoceptor-mediated increase in macrophage TG2 expression might be associated with stress-related inflammatory disorders. Catecholamines 93-107 transglutaminase 2, C polypeptide Mus musculus 154-157 24863408-3 2014 In the present study, we examined the effects of the stress-related catecholamines adrenaline and noradrenaline on macrophage expression of TG2 in RAW264.7 murine macrophages and murine bone marrow-derived macrophages. Catecholamines 68-82 transglutaminase 2, C polypeptide Mus musculus 140-143 24972051-16 2014 These data underscore the potential of TRPM4 inactivation as an approach to increase inotropy in specific conditions associated with increased catecholamine levels, such as heart failure and ischemia. Catecholamines 143-156 transient receptor potential cation channel, subfamily M, member 4 Mus musculus 39-44 25228844-0 2014 Adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with abnormal cortisol secretion mediated by catecholamines. Catecholamines 118-132 proopiomelanocortin Homo sapiens 0-27 25161195-0 2014 Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Catecholamines 42-55 activin A receptor, type IC Mus musculus 10-14 25047165-8 2014 TRPC3/4/6 expression was associated with reduced contractility and response to catecholamines during steady-state pacing, likely because of enhanced sarcoplasmic reticulum Ca2+ leak. Catecholamines 79-93 transient receptor potential cation channel, subfamily C, member 3 Mus musculus 0-5 25170769-9 2014 At lower concentrations PPA also caused accumulation of TH mRNA and protein, indicative of increased cell capacity to produce catecholamines. Catecholamines 126-140 tyrosine hydroxylase Rattus norvegicus 56-58 24075245-11 2014 CONCLUSION: In SAH patients, appetite loss may be induced by lower serum ghrelin and higher serum leptin concentrations resulting from high plasma glucose and insulin levels due to a catecholamine surge following SAH. Catecholamines 183-196 leptin Homo sapiens 98-104 24075245-11 2014 CONCLUSION: In SAH patients, appetite loss may be induced by lower serum ghrelin and higher serum leptin concentrations resulting from high plasma glucose and insulin levels due to a catecholamine surge following SAH. Catecholamines 183-196 insulin Homo sapiens 159-166 25161195-2 2014 We report that targeted disruption of TGF-beta superfamily receptor ALK7 alleviates diet-induced catecholamine resistance in adipose tissue, thereby reducing obesity in mice. Catecholamines 97-110 activin A receptor, type IC Mus musculus 68-72 25161195-6 2014 We propose that ALK7 signaling contributes to diet-induced catecholamine resistance in adipose tissue, and suggest that ALK7 inhibitors may have therapeutic value in human obesity. Catecholamines 59-72 activin A receptor type 1C Homo sapiens 16-20 25179080-1 2014 Catecholamines participate in the food intake regulation, however, there are no literature data available, dealing with the activity of tyrosine hydroxylase (TH) neurons in response to stimulation or inhibition of GHS-R (growth hormone secretagogue receptor) in the hypothalamic arcuate nucleus (ARC). Catecholamines 0-14 growth hormone secretagogue receptor Mus musculus 221-257 24747036-1 2014 PURPOSE: The objective of this study was to determine the effect of early vs late vasopressin therapy on catecholamine dose and duration. Catecholamines 105-118 arginine vasopressin Homo sapiens 82-93 24747036-3 2014 Patients were included in the early group if vasopressin was initiated within 6 hours and the late group if vasopressin was initiated between 6 and 48 hours of catecholamine(s). Catecholamines 160-173 arginine vasopressin Homo sapiens 108-119 24747036-5 2014 Vasopressin therapy was associated with a decrease in catecholamine requirements in both groups. Catecholamines 54-67 arginine vasopressin Homo sapiens 0-11 24917675-3 2014 Nevertheless, Lcn2(-/-) mice maintain normal sympathetic nervous system activation as evidenced by normal catecholamine release and lipolytic activity in response to cold stimulation. Catecholamines 106-119 lipocalin 2 Mus musculus 14-18 24905138-13 2014 CONCLUSION: EAT-released ORM levels in patients with T2DM or CAD and its regulation by catecholamines might be the mirror of local endothelium dysfunction or inflammatory process in different cardiovascular disorders. Catecholamines 87-101 orosomucoid 1 Homo sapiens 25-28 25019607-4 2014 Blockade of mGluR5 with MPEP (1 mg kg(-1) for 4 days) increased corticosterone but not catecholamine release during restraint stress (20 min). Catecholamines 87-100 glutamate receptor, ionotropic, kainate 1 Mus musculus 12-18 25199327-6 2014 Catecholamine surge was controlled with 50 microg x kg(-1) x min(-1) continuous infusion of landiolol hydrochloride and IV bolus phentolamine. Catecholamines 0-13 CD59 molecule (CD59 blood group) Homo sapiens 61-67 25114718-4 2014 We hypothesized that anti-HER2 agents would cause increased sympathetic tone with changes in plasma catecholamines and NRG. Catecholamines 100-114 erb-b2 receptor tyrosine kinase 2 Mus musculus 26-30 24737484-9 2014 In contrast, the contractile effects of histamine in the vas deferens were related to H2 receptor activation followed by release of catecholamines from sympathetic nerve endings. Catecholamines 132-146 arginine vasopressin Rattus norvegicus 57-60 25353004-5 2014 FoxO1 favors catecholamine synthesis because it is a potent regulator of the expression of Dbh that encodes the initial and rate-limiting enzyme in the synthesis of these neurotransmitters. Catecholamines 13-26 forkhead box O1 Mus musculus 0-5 25353004-5 2014 FoxO1 favors catecholamine synthesis because it is a potent regulator of the expression of Dbh that encodes the initial and rate-limiting enzyme in the synthesis of these neurotransmitters. Catecholamines 13-26 dopamine beta hydroxylase Mus musculus 91-94 24812305-4 2014 METHODS AND RESULTS: Using conditional, cardiac myocyte-specific gene deletion, we now demonstrate that mAKAPbeta expression in mice is important for the cardiac hypertrophy induced by pressure overload and catecholamine toxicity. Catecholamines 207-220 A kinase (PRKA) anchor protein 6 Mus musculus 104-113 24835632-7 2014 Moreover, we demonstrated that certain potent inhibitors of alpha-syn fibrillation, such as oxidized catecholamines and polyphenols, undergo spontaneous oxidation in aqueous solution, generating compounds that strongly quench ThT fluorescence. Catecholamines 101-115 synuclein alpha Homo sapiens 60-69 24958851-1 2014 Rett syndrome is a severe childhood onset neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein 2 (MECP2), with known disturbances in catecholamine synthesis. Catecholamines 158-171 methyl CpG binding protein 2 Mus musculus 93-121 24958851-1 2014 Rett syndrome is a severe childhood onset neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein 2 (MECP2), with known disturbances in catecholamine synthesis. Catecholamines 158-171 methyl CpG binding protein 2 Mus musculus 123-128 24865431-3 2014 Here, we determined that PM exposure results in the systemic release of catecholamines, which engage the beta2-adrenergic receptor (beta2AR) on murine alveolar macrophages and augment the release of IL-6. Catecholamines 72-86 adrenergic receptor, beta 2 Mus musculus 105-130 25064768-1 2014 The study aimed to evaluate plasma renalase level, a recently discovered kidney-derived catecholamine-metabolizing enzyme in patients after successful repair of aortic coarctation, with special consideration of arterial hypertension in the context of underlying process of arterial remodeling. Catecholamines 88-101 renalase, FAD dependent amine oxidase Homo sapiens 35-43 24865431-3 2014 Here, we determined that PM exposure results in the systemic release of catecholamines, which engage the beta2-adrenergic receptor (beta2AR) on murine alveolar macrophages and augment the release of IL-6. Catecholamines 72-86 adrenergic receptor, beta 2 Mus musculus 132-139 24865431-3 2014 Here, we determined that PM exposure results in the systemic release of catecholamines, which engage the beta2-adrenergic receptor (beta2AR) on murine alveolar macrophages and augment the release of IL-6. Catecholamines 72-86 interleukin 6 Mus musculus 199-203 24840762-9 2014 Our results suggest a potential role for vasopressin therapy in patients with CDH with catecholamine-resistant refractory hypotension. Catecholamines 87-100 arginine vasopressin Homo sapiens 41-52 25560240-1 2014 Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Catecholamines 62-75 catechol-O-methyltransferase Rattus norvegicus 0-28 24735971-6 2014 In contrast, adrenal gene expression of chromogranin A, which is cosecreted with catecholamine via the SA axis, was increased with 1 day to 2 weeks of stress, and decreased with 3-4 weeks of stress. Catecholamines 81-94 chromogranin A Mus musculus 40-54 25560240-1 2014 Catechol-O-methyltransferase (COMT) is a magnesium-dependent, catecholamine-metabolizing enzyme, whose impaired activity has been positively associated with cardiovascular diseases, particularly hypertension. Catecholamines 62-75 catechol-O-methyltransferase Rattus norvegicus 30-34 24813183-8 2014 The catecholamine (CA) secretion induced by nAChR agonist (NCT") was significantly inhibited by the pyrilamine pretreatment. Catecholamines 4-17 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 44-49 24509724-9 2014 Thus, these mice (1) support the argument that human COMT Val158Met polymorphism modulates behavioral functions and most importantly (2) exhibit the expected treatment effects supporting the "inverted U shaped" dose response of catecholamine signaling on cognitive function. Catecholamines 228-241 catechol-O-methyltransferase Homo sapiens 53-57 25058146-1 2014 Renalase, a recently discovered enzyme released by the kidneys, breaks down blood-borne catecholamines and may thus regulate blood pressure (BP). Catecholamines 88-102 renalase, FAD dependent amine oxidase Homo sapiens 0-8 24768298-0 2014 Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Catecholamines 29-42 leptin Homo sapiens 0-6 24727346-1 2014 Decreased activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, contributes to pain in humans and animals. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 22-50 24727346-1 2014 Decreased activity of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, contributes to pain in humans and animals. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 52-56 24754893-2 2014 Given the different effects of beta1-adrenoreceptor (beta1AR) and beta2-adrenoreceptor (beta2AR) stimulation by catecholamine in cardiomyocytes, this study evaluated whether simultaneous inhibition of beta1AR and activation of beta2AR is better than separate application in reducing the risk of perioperative cardiac events in aged rats undergoing non-cardiac surgery. Catecholamines 112-125 adrenoceptor beta 2 Rattus norvegicus 66-86 24754893-2 2014 Given the different effects of beta1-adrenoreceptor (beta1AR) and beta2-adrenoreceptor (beta2AR) stimulation by catecholamine in cardiomyocytes, this study evaluated whether simultaneous inhibition of beta1AR and activation of beta2AR is better than separate application in reducing the risk of perioperative cardiac events in aged rats undergoing non-cardiac surgery. Catecholamines 112-125 adrenoceptor beta 2 Rattus norvegicus 88-95 24991526-2 2014 Herein, we report new types of catecholamine PEG derivatives, PEG-NH-catechols that can utilize an expanded spectrum of catecholamine chemistry. Catecholamines 31-44 progestagen associated endometrial protein Homo sapiens 45-48 24991526-2 2014 Herein, we report new types of catecholamine PEG derivatives, PEG-NH-catechols that can utilize an expanded spectrum of catecholamine chemistry. Catecholamines 31-44 progestagen associated endometrial protein Homo sapiens 62-65 24991526-2 2014 Herein, we report new types of catecholamine PEG derivatives, PEG-NH-catechols that can utilize an expanded spectrum of catecholamine chemistry. Catecholamines 120-133 progestagen associated endometrial protein Homo sapiens 45-48 24991526-2 2014 Herein, we report new types of catecholamine PEG derivatives, PEG-NH-catechols that can utilize an expanded spectrum of catecholamine chemistry. Catecholamines 120-133 progestagen associated endometrial protein Homo sapiens 62-65 24827581-5 2014 Importantly, the sticky catecholamine-mediated AAV delivery system successfully induced a physiological response from hNSCs, cellular proliferation by a single-shot of AAV encoding fibroblast growth factor-2 (FGF-2), which is typically achieved by multiple treatments with expensive FGF-2 proteins. Catecholamines 24-37 fibroblast growth factor 2 Homo sapiens 181-207 24827581-5 2014 Importantly, the sticky catecholamine-mediated AAV delivery system successfully induced a physiological response from hNSCs, cellular proliferation by a single-shot of AAV encoding fibroblast growth factor-2 (FGF-2), which is typically achieved by multiple treatments with expensive FGF-2 proteins. Catecholamines 24-37 fibroblast growth factor 2 Homo sapiens 209-214 24827581-5 2014 Importantly, the sticky catecholamine-mediated AAV delivery system successfully induced a physiological response from hNSCs, cellular proliferation by a single-shot of AAV encoding fibroblast growth factor-2 (FGF-2), which is typically achieved by multiple treatments with expensive FGF-2 proteins. Catecholamines 24-37 fibroblast growth factor 2 Homo sapiens 283-288 24631866-10 2014 Western blotting of laser-microdissected A2 neurons revealed glucoprivic stimulation of Fos, but inhibition of the catecholamine synthetic enzyme, dopamine-beta-hydroxylase; 5TG also diminished A2 estrogen receptor (ER)-alpha and progesterone receptor profiles, but augmented ER-beta protein. Catecholamines 115-128 dopamine beta-hydroxylase Rattus norvegicus 147-172 24768298-0 2014 Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Catecholamines 29-42 histone deacetylase 4 Homo sapiens 117-122 24768298-3 2014 We show that, in the setting of acute overnutrition, leptin triggers catecholamine-dependent increases in cAMP signaling that reduce inflammatory gene expression via the activation of the histone deacetylase HDAC4. Catecholamines 69-82 leptin Homo sapiens 53-59 24768298-3 2014 We show that, in the setting of acute overnutrition, leptin triggers catecholamine-dependent increases in cAMP signaling that reduce inflammatory gene expression via the activation of the histone deacetylase HDAC4. Catecholamines 69-82 histone deacetylase 4 Homo sapiens 208-213 24037430-3 2014 MATERIAL AND METHODS: Twenty-three consecutive patients with a history of PCC/PGL, presenting with symptoms related to catecholamine excess, underwent 18F-FDG PET/CT. Catecholamines 119-132 crystallin gamma D Homo sapiens 74-77 24500282-11 2014 Mutation of the SH3 dynamin-binding domain of all syndapin isoforms shows that fusion pore expansion and catecholamine release are limited specifically by mutation of syndapin 3. Catecholamines 105-118 protein kinase C and casein kinase substrate in neurons 1 Mus musculus 50-58 24611830-11 2014 The results of the present study show that the selective DDAH-1 inhibitor L-257 improved haemodynamics, provided catecholamine sparing and prolonged survival in experimental sepsis. Catecholamines 113-126 dimethylarginine dimethylaminohydrolase 1 Homo sapiens 57-63 24511138-2 2014 Renalase, a secretory flavoprotein that oxidizes catecholamines, attenuates ischemic injury and the associated increase in catecholamine levels in mice. Catecholamines 49-63 renalase, FAD-dependent amine oxidase Mus musculus 0-8 24511138-2 2014 Renalase, a secretory flavoprotein that oxidizes catecholamines, attenuates ischemic injury and the associated increase in catecholamine levels in mice. Catecholamines 49-62 renalase, FAD-dependent amine oxidase Mus musculus 0-8 24511138-8 2014 In summary, renalase promotes cell survival and protects against renal injury in mice through the activation of intracellular signaling cascades, independent of its ability to metabolize catecholamines, and we have identified the region of renalase required for these effects. Catecholamines 187-201 renalase, FAD-dependent amine oxidase Mus musculus 12-20 24607627-1 2014 BACKGROUND & AIMS: Monoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders. Catecholamines 53-66 monoamine oxidase A Homo sapiens 23-42 24607627-1 2014 BACKGROUND & AIMS: Monoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders. Catecholamines 53-66 monoamine oxidase A Homo sapiens 44-48 24801204-11 2014 As a cAMP-activated chloride channel that facilitates calcium mobilization, we speculate wild-type CFTR co-activation during adrenergic receptor stimulation buffers the vasodilatory response to catecholamines, and loss of this compensatory vasoconstrictor tone may contribute to the lower arterial pressures seen in heterozygote carriers of a CFTR-F508del mutation. Catecholamines 194-208 cystic fibrosis transmembrane conductance regulator Mus musculus 99-103 24674967-3 2014 Here, we show that beta-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3. Catecholamines 36-50 cAMP responsive element binding protein 1 Mus musculus 91-95 24674967-3 2014 Here, we show that beta-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3. Catecholamines 36-50 CREB regulated transcription coactivator 2 Mus musculus 178-183 24674967-3 2014 Here, we show that beta-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3. Catecholamines 36-50 CREB regulated transcription coactivator 3 Mus musculus 188-193 24417771-2 2014 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the biosynthesis of catecholamine, including dopamine and noradrenaline. Catecholamines 78-91 tyrosine hydroxylase Homo sapiens 0-20 24417771-2 2014 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the biosynthesis of catecholamine, including dopamine and noradrenaline. Catecholamines 78-91 tyrosine hydroxylase Homo sapiens 22-24 24417771-9 2014 CONCLUSIONS: The present data suggest that the biosynthesis of catecholamine by the action of TH should be deeply involved in decreased intellectual ability in patients with schizophrenia. Catecholamines 63-76 tyrosine hydroxylase Homo sapiens 94-96 24500282-11 2014 Mutation of the SH3 dynamin-binding domain of all syndapin isoforms shows that fusion pore expansion and catecholamine release are limited specifically by mutation of syndapin 3. Catecholamines 105-118 protein kinase C and casein kinase substrate in neurons 1 Mus musculus 167-175 24614323-3 2014 Catecholamine can activate connexin43 to regulate cell death. Catecholamines 0-13 gap junction protein, alpha 1 Rattus norvegicus 27-37 24617700-5 2014 In contrast, neurons in this RVLM region, including catecholamine-synthesizing neurons, did express c-Fos following induced hypotension, which reflexly activates RVLM sympathetic premotor neurons. Catecholamines 52-65 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 100-105 24497580-0 2014 The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. Catecholamines 81-94 VGF nerve growth factor inducible Mus musculus 11-14 24497580-2 2014 Adrenal LDCV formation involves the granin proteins chromogranin A (CgA) and chromogranin B (CgB); CgA- and CgB-derived peptides regulate catecholamine levels and blood pressure. Catecholamines 138-151 chromogranin A Mus musculus 52-66 24497580-2 2014 Adrenal LDCV formation involves the granin proteins chromogranin A (CgA) and chromogranin B (CgB); CgA- and CgB-derived peptides regulate catecholamine levels and blood pressure. Catecholamines 138-151 chromogranin A Mus musculus 68-71 24497580-2 2014 Adrenal LDCV formation involves the granin proteins chromogranin A (CgA) and chromogranin B (CgB); CgA- and CgB-derived peptides regulate catecholamine levels and blood pressure. Catecholamines 138-151 chromogranin B Mus musculus 93-96 24497580-2 2014 Adrenal LDCV formation involves the granin proteins chromogranin A (CgA) and chromogranin B (CgB); CgA- and CgB-derived peptides regulate catecholamine levels and blood pressure. Catecholamines 138-151 chromogranin A Mus musculus 99-102 24497580-2 2014 Adrenal LDCV formation involves the granin proteins chromogranin A (CgA) and chromogranin B (CgB); CgA- and CgB-derived peptides regulate catecholamine levels and blood pressure. Catecholamines 138-151 chromogranin B Mus musculus 108-111 24497580-9 2014 Our studies establish a role for VGF in adrenal LDCV formation and the regulation of catecholamine levels and blood pressure. Catecholamines 85-98 VGF nerve growth factor inducible Mus musculus 33-36 24822046-2 2014 Mitochondrial CaMKII promotes poor outcomes after heart injury from a number of pathological conditions, including myocardial infarction (MI), ischemia reperfusion (IR), and stress from catecholamine stimulation. Catecholamines 186-199 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 14-20 24467942-1 2014 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 24467942-1 2014 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 24535440-6 2014 Consistent with these data, mRNAs coding for catecholamine synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine-beta-hydroxylase were detected by RT-PCR in cultured endothelial cells from SMA. Catecholamines 45-58 tyrosine hydroxylase Homo sapiens 86-106 24671122-1 2014 Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with catecholamines and can function as a pro-hormone by giving rise to several bioactive peptides. Catecholamines 88-102 chromogranin A Homo sapiens 0-14 24671122-1 2014 Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with catecholamines and can function as a pro-hormone by giving rise to several bioactive peptides. Catecholamines 88-102 chromogranin A Homo sapiens 16-19 24671122-1 2014 Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with catecholamines and can function as a pro-hormone by giving rise to several bioactive peptides. Catecholamines 88-102 chromogranin A Homo sapiens 21-25 24795691-5 2014 By a newly established method, using tyramine-stimulated release through the norepinephrine transporter (NET), presynaptic control of catecholamine release was studied in normotensive and spontaneously hypertensive rats. Catecholamines 134-147 solute carrier family 6 member 2 Rattus norvegicus 77-103 24742207-1 2014 BACKGROUND AND OBJECTIVES: Renalase, a monoamine oxidase derived from the kidney, can degrade catecholamine (CA) and regulate blood pressure as well as cardiac function. Catecholamines 94-107 renalase, FAD dependent amine oxidase Homo sapiens 27-35 24573553-1 2014 PURPOSE: The norepinephrine transporter (NET) is a critical regulator of catecholamine uptake in normal physiology and is expressed in neuroendocrine tumors like neuroblastoma. Catecholamines 73-86 solute carrier family 6 member 2 Homo sapiens 13-39 24573553-1 2014 PURPOSE: The norepinephrine transporter (NET) is a critical regulator of catecholamine uptake in normal physiology and is expressed in neuroendocrine tumors like neuroblastoma. Catecholamines 73-86 solute carrier family 6 member 2 Homo sapiens 41-44 24535440-6 2014 Consistent with these data, mRNAs coding for catecholamine synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine-beta-hydroxylase were detected by RT-PCR in cultured endothelial cells from SMA. Catecholamines 45-58 tyrosine hydroxylase Homo sapiens 108-110 24535440-6 2014 Consistent with these data, mRNAs coding for catecholamine synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine-beta-hydroxylase were detected by RT-PCR in cultured endothelial cells from SMA. Catecholamines 45-58 dopamine beta-hydroxylase Homo sapiens 154-179 24485840-8 2014 In the paper we review studies on hemodynamic effects of catecholamines, neuropeptide Y, angiotensin II, aldosterone, natriuretic peptides, endothelins, histamine and bradykinin in the context of their role in a cross-talk between peripheral and brain mechanisms involved in the regulation of arterial blood pressure. Catecholamines 57-71 kininogen 1 Homo sapiens 167-177 24361276-1 2014 Tyrosine hydroxylase (TyrH) catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine in the biosynthesis of the catecholamine neurotransmitters. Catecholamines 130-143 tyrosine hydroxylase Rattus norvegicus 0-20 24361276-1 2014 Tyrosine hydroxylase (TyrH) catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylalanine in the biosynthesis of the catecholamine neurotransmitters. Catecholamines 130-143 tyrosine hydroxylase Rattus norvegicus 22-26 24599883-1 2014 Renalase is a recently described enzyme secreted by the kidney into both plasma and urine, where it was suggested to degrade catecholamines contributing to blood pressure control. Catecholamines 125-139 renalase, FAD dependent amine oxidase Homo sapiens 0-8 24266713-0 2014 Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. Catecholamines 65-78 chromogranin B Homo sapiens 0-14 24266713-1 2014 Chromogranin B (CHGB) is the major matrix protein in human catecholamine storage vesicles. Catecholamines 59-72 chromogranin B Homo sapiens 0-14 24266713-1 2014 Chromogranin B (CHGB) is the major matrix protein in human catecholamine storage vesicles. Catecholamines 59-72 chromogranin B Homo sapiens 16-20 24266713-2 2014 CHGB genetic variation alters catecholamine secretion and blood pressure. Catecholamines 30-43 chromogranin B Homo sapiens 0-4 24266713-3 2014 Here, effective Chgb protein under-expression was achieved by siRNA in PC12 cells, resulting in ~ 48% fewer secretory granules on electron microscopy, diminished capacity for catecholamine uptake (by ~ 79%), and a ~ 73% decline in stores available for nicotinic cholinergic-stimulated secretion. Catecholamines 175-188 chromogranin B Rattus norvegicus 16-20 24266713-4 2014 In vivo, loss of Chgb in knockout mice resulted in a ~ 35% decline in chromaffin granule abundance and ~ 44% decline in granule diameter, accompanied by unregulated catecholamine release into plasma. Catecholamines 165-178 chromogranin B Mus musculus 17-21 24266713-5 2014 Over-expression of CHGB was achieved by transduction of a CHGB-expressing lentivirus, resulting in ~ 127% elevation in CHGB protein, with ~ 122% greater abundance of secretory granules, but only ~ 14% increased uptake of catecholamines, and no effect on nicotinic-triggered secretion. Catecholamines 221-235 chromogranin B Homo sapiens 19-23 24266713-5 2014 Over-expression of CHGB was achieved by transduction of a CHGB-expressing lentivirus, resulting in ~ 127% elevation in CHGB protein, with ~ 122% greater abundance of secretory granules, but only ~ 14% increased uptake of catecholamines, and no effect on nicotinic-triggered secretion. Catecholamines 221-235 chromogranin B Homo sapiens 58-62 24266713-5 2014 Over-expression of CHGB was achieved by transduction of a CHGB-expressing lentivirus, resulting in ~ 127% elevation in CHGB protein, with ~ 122% greater abundance of secretory granules, but only ~ 14% increased uptake of catecholamines, and no effect on nicotinic-triggered secretion. Catecholamines 221-235 chromogranin B Homo sapiens 58-62 24266713-6 2014 Human CHGB protein and its proteolytic fragments inhibited nicotinic-stimulated catecholamine release by ~ 72%. Catecholamines 80-93 chromogranin B Homo sapiens 6-10 24266713-8 2014 We conclude that bi-directional quantitative derangements in CHGB abundance result in profound changes in vesicular storage and release of catecholamines. Catecholamines 139-153 chromogranin B Homo sapiens 61-65 24266713-9 2014 When processed and released extra-cellularly, CHGB proteolytic fragments exert a feedback effect to inhibit catecholamine secretion, especially during nicotinic cholinergic stimulation. Catecholamines 108-121 chromogranin B Homo sapiens 46-50 24389396-1 2014 Catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters within the brain. Catecholamines 75-88 catechol-O-methyltransferase Homo sapiens 0-28 24389396-1 2014 Catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters within the brain. Catecholamines 75-88 catechol-O-methyltransferase Homo sapiens 30-34 24467715-1 2014 BACKGROUND: Measurement of plasma/urinary catecholamine metabolites--especially normetanephrine (NMN)--represents a gold standard in biochemical detection of succinate dehydrogenase subunit B (SDHB) and D (SDHD)-related pheochromocytomas (PHEO) and paragangliomas (PGL). Catecholamines 42-55 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 158-191 24467715-1 2014 BACKGROUND: Measurement of plasma/urinary catecholamine metabolites--especially normetanephrine (NMN)--represents a gold standard in biochemical detection of succinate dehydrogenase subunit B (SDHB) and D (SDHD)-related pheochromocytomas (PHEO) and paragangliomas (PGL). Catecholamines 42-55 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 193-197 24467715-1 2014 BACKGROUND: Measurement of plasma/urinary catecholamine metabolites--especially normetanephrine (NMN)--represents a gold standard in biochemical detection of succinate dehydrogenase subunit B (SDHB) and D (SDHD)-related pheochromocytomas (PHEO) and paragangliomas (PGL). Catecholamines 42-55 succinate dehydrogenase complex subunit D Homo sapiens 206-210 24636497-2 2014 Ample studies showed suppression of IL-12 production by numerous stress factors, including prostaglandins, catecholamines, glucocorticoids, and opioids, but did so in vitro and in the context of artificial leukocyte activation, not simulating the in vivo setting. Catecholamines 107-121 interleukin 12B Rattus norvegicus 36-41 24374096-0 2014 Rapid induction of REDD1 gene expression in macrophages in response to stress-related catecholamines. Catecholamines 86-100 DNA-damage-inducible transcript 4 Mus musculus 19-24 24285555-1 2014 Voltammetric measurements of catecholamines in the medial prefrontal cortex (mPFC) are infrequent because of lack of chemical selectivity between dopamine and norepinephrine and their overlapping anatomical inputs. Catecholamines 29-43 complement factor properdin Mus musculus 77-81 24285555-2 2014 Here, we examined the contribution of norepinephrine to the catecholamine release in the mPFC evoked by electrical stimulation of the ventral tegmental area (VTA). Catecholamines 60-73 complement factor properdin Mus musculus 89-93 24603879-0 2014 Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells. Catecholamines 61-74 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-50 24603879-3 2014 In the present study, we investigate the effects of PACAP on catecholamine storage and secretion in PC12 cells with amperometry and transmission electron microscopy (TEM). Catecholamines 61-74 adenylate cyclase activating polypeptide 1 Rattus norvegicus 52-57 24368671-4 2014 The serum TG reduction was associated with a repression of both catecholamine-stimulated lipolysis and relative glucose incorporation into lipid in isolated adipocytes through activation of LXRbeta. Catecholamines 64-77 nuclear receptor subfamily 1, group H, member 2 Mus musculus 190-197 24568153-1 2014 GPCR-mediated receptor transactivation of EGFR, is one of the effector mechanisms by which GPCR ligands, such as Ang II, thrombin and ET -1, catecholamine, SII-angiotensin, PAF, and uPA that are released at the arterial injury sites, can potentiate intimal hyperplasia. Catecholamines 141-154 epidermal growth factor receptor Homo sapiens 42-46 24285555-8 2014 Specifically, raclopride reduced catecholamine release in the mPFC, opposite to that observed in the striatum, indicating differential autoreceptor regulation of mesocortical and mesostriatal neurons. Catecholamines 33-46 complement factor properdin Mus musculus 62-66 24285555-9 2014 Together, these findings suggest that the catecholamine release in the mPFC arising from VTA stimulation was predominately dopaminergic rather than noradrenergic. Catecholamines 42-55 complement factor properdin Mus musculus 71-75 24118769-1 2014 AIM: This study in the anaesthetized rat investigated how renal sympathetic nerve activity and catecholamine release influenced NHE3 abundance and activity in proximal tubular brush border membranes using both in vivo and in vitro approaches. Catecholamines 95-108 solute carrier family 9 member A3 Rattus norvegicus 128-132 24406448-4 2014 In heart failure with preserved left ventricular ejection fraction, BNP elevation may also facilitate diagnosis, although its precise utility is uncertain.In the acute catecholamine-induced myocardial inflammatory condition of Tako-Tsubo cardiomyopathy (TTC), BNP/NT-Pro-BNP elevations are marked and persist for at least 3 months, despite the absence of pulmonary oedema. Catecholamines 168-181 natriuretic peptide B Homo sapiens 68-71 24406448-4 2014 In heart failure with preserved left ventricular ejection fraction, BNP elevation may also facilitate diagnosis, although its precise utility is uncertain.In the acute catecholamine-induced myocardial inflammatory condition of Tako-Tsubo cardiomyopathy (TTC), BNP/NT-Pro-BNP elevations are marked and persist for at least 3 months, despite the absence of pulmonary oedema. Catecholamines 168-181 natriuretic peptide B Homo sapiens 260-263 24406448-4 2014 In heart failure with preserved left ventricular ejection fraction, BNP elevation may also facilitate diagnosis, although its precise utility is uncertain.In the acute catecholamine-induced myocardial inflammatory condition of Tako-Tsubo cardiomyopathy (TTC), BNP/NT-Pro-BNP elevations are marked and persist for at least 3 months, despite the absence of pulmonary oedema. Catecholamines 168-181 natriuretic peptide B Homo sapiens 260-263 24711750-1 2014 Dopamine-beta-hydroxylase (DBH) is a neurotransmitter (catecholamine)-mediating enzyme, which catalyzes the formation of norepinephrine from dopamine. Catecholamines 55-68 dopamine beta-hydroxylase Homo sapiens 0-25 24711750-1 2014 Dopamine-beta-hydroxylase (DBH) is a neurotransmitter (catecholamine)-mediating enzyme, which catalyzes the formation of norepinephrine from dopamine. Catecholamines 55-68 dopamine beta-hydroxylase Homo sapiens 27-30 24374096-1 2014 In the present study, we examined the effect of stress-related catecholamines adrenaline and noradrenaline on macrophage expression of a new host defense factor REDD1 using murine macrophage cell line RAW264.7 and murine peritoneal macrophages. Catecholamines 63-77 DNA-damage-inducible transcript 4 Mus musculus 161-166 24567123-10 2014 In cell culture studies, HDL and apoA-I specifically increased catecholamine-induced lipolysis possibly through modulating the adipocyte plasma membrane cholesterol content. Catecholamines 63-76 apolipoprotein A-I Mus musculus 33-39 24037783-9 2014 Thus, activation of beta1/2 adrenergic receptors expressed in spinal astrocytes could be a novel method of moderating neurological disorders with endogenous catecholamines or selective agonists. Catecholamines 157-171 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 20-27 24121404-0 2014 Catecholamine stress alters neutrophil trafficking and impairs wound healing by beta2-adrenergic receptor-mediated upregulation of IL-6. Catecholamines 0-13 adrenergic receptor, beta 2 Mus musculus 80-105 24121404-0 2014 Catecholamine stress alters neutrophil trafficking and impairs wound healing by beta2-adrenergic receptor-mediated upregulation of IL-6. Catecholamines 0-13 interleukin 6 Mus musculus 131-135 23963787-1 2014 Catechol-O-methyltransferase, encoded by COMT gene, is the primary enzyme that metabolizes catecholamines. Catecholamines 91-105 catechol-O-methyltransferase Homo sapiens 0-28 23963787-1 2014 Catechol-O-methyltransferase, encoded by COMT gene, is the primary enzyme that metabolizes catecholamines. Catecholamines 91-105 catechol-O-methyltransferase Homo sapiens 41-45 23508458-2 2014 Therefore, we quantified catecholamine and the expression of catecholamine synthetic enzymes in the adrenal glands of senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice placed in an AA-deficient state. Catecholamines 61-74 regucalcin Mus musculus 118-146 24326420-7 2014 Adipose expression of miR-378 associated strongly and positively with catecholamine-stimulated lipolysis in adipocytes. Catecholamines 70-83 microRNA 378a Homo sapiens 22-29 24326420-8 2014 This correlation is most probably causal because overexpression of miR-378 in human adipocytes increased catecholamine-stimulated lipolysis. Catecholamines 105-118 microRNA 378a Homo sapiens 67-74 23508458-2 2014 Therefore, we quantified catecholamine and the expression of catecholamine synthetic enzymes in the adrenal glands of senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice placed in an AA-deficient state. Catecholamines 61-74 regucalcin Mus musculus 173-176 24117685-3 2014 PP2A dephosphorylates many neuroproteins, including the catecholamine rate-limiting enzyme, tyrosine hydroxylase (TH). Catecholamines 56-69 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 0-4 24117685-3 2014 PP2A dephosphorylates many neuroproteins, including the catecholamine rate-limiting enzyme, tyrosine hydroxylase (TH). Catecholamines 56-69 tyrosine hydroxylase Mus musculus 92-112 24117685-3 2014 PP2A dephosphorylates many neuroproteins, including the catecholamine rate-limiting enzyme, tyrosine hydroxylase (TH). Catecholamines 56-69 tyrosine hydroxylase Mus musculus 114-116 24117685-9 2014 Low adrenal PP2A activity co-occurred with TH hyperactivity, making this the first study to link adrenal synucleinopathy to anxiety and catecholamine dysregulation. Catecholamines 136-149 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 12-16 24460628-0 2014 Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator. Catecholamines 100-113 catechol-O-methyltransferase Homo sapiens 75-79 24342707-2 2014 Enzymes like catechol-O-methyl-transferase (COMT) are involved in the elimination of catecholamines playing a possible role in central sensitization and pain. Catecholamines 85-99 catechol-O-methyltransferase Homo sapiens 13-42 24342707-2 2014 Enzymes like catechol-O-methyl-transferase (COMT) are involved in the elimination of catecholamines playing a possible role in central sensitization and pain. Catecholamines 85-99 catechol-O-methyltransferase Homo sapiens 44-48 24575113-2 2014 Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 115-128 catechol-O-methyltransferase Homo sapiens 0-28 24575113-2 2014 Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 115-128 catechol-O-methyltransferase Homo sapiens 30-34 24925409-4 2014 In 1939, dopa decarboxylase was the first enzyme in the biosynthesis of catecholamines to be described. Catecholamines 72-86 dopa decarboxylase Homo sapiens 9-27 24055376-1 2014 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamine neurotransmitters, and a reduction in TH activity is associated with several neurological diseases. Catecholamines 79-92 tyrosine hydroxylase Homo sapiens 0-20 24055376-1 2014 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamine neurotransmitters, and a reduction in TH activity is associated with several neurological diseases. Catecholamines 79-92 tyrosine hydroxylase Homo sapiens 22-24 24138638-2 2014 Activation of brain CB1 receptors inhibited the secretion of adrenal catecholamines (noradrenaline and adrenaline) induced by i.c.v. Catecholamines 69-83 cannabinoid receptor 1 Rattus norvegicus 20-23 25136449-4 2014 A catecholamine-secreting carotid body paraganglioma (CSCBP) was suspected; the diagnosis was confirmed biochemically by determining plasma norepinephrine (NE) level, 89 000 pmol/l, and chromogranin A (CgA) level, 279 mug/l. Catecholamines 2-15 chromogranin A Homo sapiens 202-205 25230230-4 2014 This reaction is considered as rate-limiting step in the biosynthesis of catecholamines, dopamine, norepinephrine and epinephrine, which has made TH an important target for drug development. Catecholamines 73-87 tyrosine hydroxylase Homo sapiens 146-148 25567503-2 2014 In contrast to other monoamine oxidases, renalase can be secreted into both plasma and urine where it has been suggested to metabolise catecholamines and contribute to blood pressure control. Catecholamines 135-149 renalase, FAD-dependent amine oxidase Rattus norvegicus 41-49 25567503-3 2014 Renalase was first reported to be undetectable in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), suggesting a causal link between the reduced plasma renalase levels, increased plasma catecholamine, and heightened cardiovascular risk that are well documented in this population. Catecholamines 215-228 renalase, FAD dependent amine oxidase Homo sapiens 0-8 24642449-8 2014 Interestingly, catecholamines signaled through the beta2-adrenergic receptor but not the canonical cAMP/protein kinase A signaling pathway. Catecholamines 15-29 adrenergic receptor, beta 2 Mus musculus 51-76 25057275-1 2014 Electrical vagus nerve (VN) stimulation during sepsis attenuates tumor necrosis factor (TNF) production through the cholinergic anti-inflammatory pathway, which depends on the integrity of the VN and catecholamine production. Catecholamines 200-213 tumor necrosis factor-like Rattus norvegicus 88-91 24188886-5 2014 Here, we will focus on the non-genomic actions of ecdysteroids on a Drosophila GPCR, DopEcR (CG18314), which can be activated by both ecdysone and the catecholamine, dopamine. Catecholamines 151-164 Octopamine receptor in mushroom bodies Drosophila melanogaster 79-83 24188886-5 2014 Here, we will focus on the non-genomic actions of ecdysteroids on a Drosophila GPCR, DopEcR (CG18314), which can be activated by both ecdysone and the catecholamine, dopamine. Catecholamines 151-164 Dopamine/Ecdysteroid receptor Drosophila melanogaster 85-91 24188886-5 2014 Here, we will focus on the non-genomic actions of ecdysteroids on a Drosophila GPCR, DopEcR (CG18314), which can be activated by both ecdysone and the catecholamine, dopamine. Catecholamines 151-164 Dopamine/Ecdysteroid receptor Drosophila melanogaster 93-100 24899891-1 2014 Hyperglycemia (HG) and insulin resistance are the hallmarks of a profoundly altered metabolism in critical illness resulting from the release of cortisol, catecholamines, and cytokines, as well as glucagon and growth hormone. Catecholamines 155-169 insulin Homo sapiens 23-30 24772448-1 2014 Alpha(1D)-adrenergic receptor (alpha(1D)-AR) plays important roles in regulating physiological and pathological responses mediated by catecholamines, particularly in the cardiovascular and urinary systems. Catecholamines 134-148 adrenoceptor alpha 1D Rattus norvegicus 0-29 24772448-1 2014 Alpha(1D)-adrenergic receptor (alpha(1D)-AR) plays important roles in regulating physiological and pathological responses mediated by catecholamines, particularly in the cardiovascular and urinary systems. Catecholamines 134-148 adrenoceptor alpha 1D Rattus norvegicus 31-43 25531090-1 2014 BACKGROUND/AIMS: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 142-156 renalase, FAD dependent amine oxidase Homo sapiens 17-25 24492414-4 2014 Daidzein (0.01 - 1.0 muM), a soy isoflavone, stimulated (14)C-catecholamine synthesis through plasma membrane estrogen receptors. Catecholamines 62-75 latexin Homo sapiens 21-24 24492414-5 2014 Nobiletin (1.0 - 100 muM), a citrus polymethoxy flavone, enhanced (14)C-catecholamine synthesis through the phosphorylation of Ser19 and Ser40 of tyrosine hydroxylase, which was associated with (45)Ca(2+) influx and catecholamine secretion. Catecholamines 72-85 latexin Homo sapiens 21-24 24492414-7 2014 Daidzein as well as nobiletin (>= 1.0 muM) inhibited catecholamine synthesis and secretion induced by acetylcholine, a physiological secretagogue. Catecholamines 56-69 latexin Homo sapiens 41-44 25171187-1 2014 BACKGROUND/AIMS: Renalase is a recently discovered, kidney-specific monoamine oxidase that metabolizes circulating catecholamines. Catecholamines 115-129 renalase, FAD dependent amine oxidase Homo sapiens 17-25 25171187-3 2014 Previous data demonstrated that renalase was mainly secreted from proximal tubules which could be evoked by catecholamines. Catecholamines 108-122 renalase, FAD dependent amine oxidase Homo sapiens 32-40 25531090-1 2014 BACKGROUND/AIMS: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 142-156 renalase, FAD dependent amine oxidase Homo sapiens 37-41 24137013-1 2014 Renalase, a recently discovered flavoprotein, which is strongly expressed in the kidney and heart, effectively metabolizes catecholamines. Catecholamines 123-137 renalase, FAD dependent amine oxidase Homo sapiens 0-8 25790708-3 2014 The authors review modern concepts of AH development in patients with insulin resistance associated with enhanced blood insulin level and increased production of catecholamines playing an important role in AH pathogenesis mediated through sympathetic stimulation of heart, vessels while kidneys. Catecholamines 162-176 insulin Homo sapiens 70-77 24239562-0 2014 Peripheral oxytocin treatment affects the rat adreno-medullary catecholamine content modulating expression of vesicular monoamine transporter 2. Catecholamines 63-76 solute carrier family 18 member A2 Rattus norvegicus 110-143 24025942-11 2014 The coordinate loss of dopamine and norepinephrine neurons in VMAT2 LO mice parallels the pattern of neurodegeneration that occurs in human PD, and demonstrates that insufficient catecholamine storage can cause spontaneous degeneration in susceptible neurons, underscoring cytosolic catecholamine catabolism as a determinant of neuronal susceptibility in PD. Catecholamines 179-192 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 62-67 24025942-11 2014 The coordinate loss of dopamine and norepinephrine neurons in VMAT2 LO mice parallels the pattern of neurodegeneration that occurs in human PD, and demonstrates that insufficient catecholamine storage can cause spontaneous degeneration in susceptible neurons, underscoring cytosolic catecholamine catabolism as a determinant of neuronal susceptibility in PD. Catecholamines 283-296 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 62-67 24239562-8 2014 These findings indicate that oxytocin treatment increases catecholamine content in the rat adrenal medulla modulating VMAT2 expression. Catecholamines 58-71 solute carrier family 18 member A2 Rattus norvegicus 118-123 24144187-3 2013 Herein, the interaction of Ngb with the quinones generated by oxidation of catecholamines (dopamine, norepinephrine) and catechol estrogens (2-hydroxyestradiol and 4-hydroxyestradiol), which have been implicated in neurodegenerative pathologies like Parkinson"s and Alzheimer"s diseases, has been investigated. Catecholamines 75-89 neuroglobin Homo sapiens 27-30 24373196-0 2013 Xiaochaihu Decoction attenuates the vicious circle between the oxidative stress and the ALP inactivation through LPS-catecholamines interactions in gut, liver and brain during CCI4+ethanol-induced mouse HCC. Catecholamines 117-131 alopecia, recessive Mus musculus 88-91 24368730-0 2013 Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKepsilon and TBK1. Catecholamines 22-35 phosphodiesterase 3B, cGMP-inhibited Mus musculus 76-81 24368730-0 2013 Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKepsilon and TBK1. Catecholamines 22-35 inhibitor of kappaB kinase epsilon Mus musculus 105-115 24368730-0 2013 Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKepsilon and TBK1. Catecholamines 22-35 TANK-binding kinase 1 Mus musculus 120-124 24368730-5 2013 Noncanonical IKKs reduce catecholamine sensitivity by phosphorylating and activating the major adipocyte phosphodiesterase PDE3B. Catecholamines 25-38 phosphodiesterase 3B, cGMP-inhibited Mus musculus 123-128 24379274-3 2013 Renalase, with possible monoamine oxidase activity, which breaks down catecholamines such as SSAO, is expressed in the endothelium as well as in the kidney. Catecholamines 70-84 amine oxidase copper containing 3 Homo sapiens 93-97 25033547-1 2014 Renalase, a recently discovered protein participating in the catecholamine metabolism and belonging to oxidoreductases, possess also antihypertensive and cardioprotective properties, confirmed in several studies on animal models. Catecholamines 61-74 renalase, FAD dependent amine oxidase Homo sapiens 0-8 24144187-5 2013 Combined studies of tandem mass spectrometry and protein unfolding indicate the presence of quinone-promoted modifications in all of the Ngb derivatives analyzed (i.e., obtained employing either catecholamines or catechol estrogens as the source of the reactive species). Catecholamines 195-209 neuroglobin Homo sapiens 137-140 24144187-8 2013 The whole analysis of the data of Ngb modification suggests that the catecholamine-oxidation products can extensively modify proteins (likely by catecholamine oligomers, the compounds initially formed during the transformation of catecholamine to melanin). Catecholamines 69-82 neuroglobin Homo sapiens 34-37 24144187-8 2013 The whole analysis of the data of Ngb modification suggests that the catecholamine-oxidation products can extensively modify proteins (likely by catecholamine oligomers, the compounds initially formed during the transformation of catecholamine to melanin). Catecholamines 145-158 neuroglobin Homo sapiens 34-37 24144187-8 2013 The whole analysis of the data of Ngb modification suggests that the catecholamine-oxidation products can extensively modify proteins (likely by catecholamine oligomers, the compounds initially formed during the transformation of catecholamine to melanin). Catecholamines 145-158 neuroglobin Homo sapiens 34-37 24266457-2 2013 The consensus belief has been that renalase oxidizes circulating catecholamine neurotransmitters thereby attenuating vascular tone. Catecholamines 65-78 renalase, FAD dependent amine oxidase Homo sapiens 35-43 24157129-0 2013 Gonadal hormone dependent developmental plasticity of catecholamine:beta2-adrenoceptor signaling complex in male rat thymus: putative implications for thymopoiesis. Catecholamines 54-67 adrenoceptor beta 2 Rattus norvegicus 68-86 24157129-1 2013 The study was undertaken considering that: i) androgens affect beta2-adrenoceptor (AR)-mediated catecholamine (CA) action in many tissues; and ii) peripubertal changes in both circulating androgen and thymic CA levels are implicated in rat thymic involution. Catecholamines 96-109 adrenoceptor beta 2 Rattus norvegicus 63-81 24157129-1 2013 The study was undertaken considering that: i) androgens affect beta2-adrenoceptor (AR)-mediated catecholamine (CA) action in many tissues; and ii) peripubertal changes in both circulating androgen and thymic CA levels are implicated in rat thymic involution. Catecholamines 96-109 adrenoceptor beta 2 Rattus norvegicus 83-85 24064356-1 2013 Using the retrogradely transported immunotoxin, antidopamine beta-hydroxylase-saporin (DSAP), we showed previously that hindbrain catecholamine neurons innervating corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus are required for glucoprivation-induced corticosterone secretion. Catecholamines 130-143 corticotropin releasing hormone Rattus norvegicus 164-195 24343288-1 2013 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in different tissues. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 24343288-1 2013 BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in different tissues. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 23786442-1 2013 The Syrian Cardiomyopathic Hamster (BIO-14.6/53.58 strains) model of cardiac failure, resulting from naturally occurring deletion at the SGCD (delta-sarcoglycan) locus, displays widespread disturbances in catecholamine metabolism. Catecholamines 205-218 sarcoglycan delta Homo sapiens 143-160 26266790-0 2013 Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock. Catecholamines 32-45 adrenomedullin Mus musculus 0-14 24283218-2 2013 In addition, tyrosine hydroxylase, the rate-limiting enzyme for the synthesis of catecholamines, is expressed in 8-10% of dorsal root ganglia (DRG) neurons, suggesting that dopamine may be released in the dorsal root ganglia. Catecholamines 81-95 tyrosine hydroxylase Homo sapiens 13-33 22292987-5 2013 The catecholamine producing enzyme tyrosine hydroxylase and the alpha-2A-adrenoreceptor (alpha2A AR) were expressed by tenocytes, and alpha-2 adrenergic stimulation had a proliferative effect on these cells, in both models. Catecholamines 4-17 adrenoceptor alpha 2A Homo sapiens 89-99 22292987-7 2013 The results indicate that catecholamines produced by tenocytes in tendinosis might contribute to the proliferative nature of the pathology through stimulation of the alpha2A AR, pointing to a novel target for future therapies. Catecholamines 26-40 adrenoceptor alpha 2A Homo sapiens 166-176 24366404-1 2013 Renalase is a newly discovered amine oxidase and may lower blood pressure by metabolizing catecholamines. Catecholamines 90-104 renalase, FAD-dependent amine oxidase Rattus norvegicus 0-8 24259582-1 2013 We have shown that an antibody to dopamine-beta-hydroxylase conjugated with saporin (anti-DBH-SAP) damages catecholamine neurons in the nucleus tractus solitarii (NTS) of rat, attenuates arterial baroreflexes, and leads to lability of arterial blood pressure, damage to cardiac myocytes, and, in some animals, sudden death. Catecholamines 107-120 dopamine beta-hydroxylase Rattus norvegicus 34-59 24282555-0 2013 A potential benefit of albinism in Astyanax cavefish: downregulation of the oca2 gene increases tyrosine and catecholamine levels as an alternative to melanin synthesis. Catecholamines 109-122 P protein Astyanax mexicanus 76-80 24259582-1 2013 We have shown that an antibody to dopamine-beta-hydroxylase conjugated with saporin (anti-DBH-SAP) damages catecholamine neurons in the nucleus tractus solitarii (NTS) of rat, attenuates arterial baroreflexes, and leads to lability of arterial blood pressure, damage to cardiac myocytes, and, in some animals, sudden death. Catecholamines 107-120 amyloid P component, serum Rattus norvegicus 94-97 24225056-2 2013 Excess stimulation of beta-adrenergic receptors by catecholamines causes phosphorylation/activation of cAMP response element binding protein (CREB) by the cAMP signaling pathway. Catecholamines 51-65 cAMP responsive element binding protein 1 Mus musculus 103-140 24225056-2 2013 Excess stimulation of beta-adrenergic receptors by catecholamines causes phosphorylation/activation of cAMP response element binding protein (CREB) by the cAMP signaling pathway. Catecholamines 51-65 cAMP responsive element binding protein 1 Mus musculus 142-146 24250787-1 2013 beta-blockers are widely used to improve symptoms and prolong life in heart disease primarily by inhibiting the actions of endogenous catecholamines at the beta1-adrenoceptor. Catecholamines 134-148 adrenoceptor beta 1 Homo sapiens 156-174 24250787-3 2013 The beta1-adrenoceptor also exists in two agonist conformations - a high affinity catecholamine conformation and a low affinity secondary agonist conformation. Catecholamines 82-95 adrenoceptor beta 1 Homo sapiens 4-22 24037885-6 2013 Indeed, these results indicated an aromatic L-amino acid decarboxylase deficiency that impairs the synthesis of serotonin, dopamine, and catecholamines. Catecholamines 137-151 dopa decarboxylase Homo sapiens 35-70 24052031-3 2013 Furthermore, epinephrine increases IL-6 secretion from skeletal muscle, suggesting that IL-6 could play a role in mediating the lipolytic effects of catecholamines. Catecholamines 149-163 interleukin 6 Mus musculus 35-39 24052031-3 2013 Furthermore, epinephrine increases IL-6 secretion from skeletal muscle, suggesting that IL-6 could play a role in mediating the lipolytic effects of catecholamines. Catecholamines 149-163 interleukin 6 Mus musculus 88-92 24139460-1 2013 In a previous study, acupuncture at acupoint HT7 attenuated ethanol withdrawal-induced anxiety-like behavior in rats by normalizing amygdaloid catecholamines. Catecholamines 143-157 basigin (Ok blood group) Rattus norvegicus 45-48 25069256-7 2013 It is likely that methylphenidate and nisoxetine activate the prefrontal catecholamine systems by blocking the norepinephrine transporter (NET) function, thereby helping to improve AD/HD-like behavior in DAT KO mice. Catecholamines 73-86 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 111-137 25069256-7 2013 It is likely that methylphenidate and nisoxetine activate the prefrontal catecholamine systems by blocking the norepinephrine transporter (NET) function, thereby helping to improve AD/HD-like behavior in DAT KO mice. Catecholamines 73-86 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 204-207 24056936-6 2013 Here we present structures of the active-state human beta2AR bound to three chemically distinct agonists: the ultrahigh-affinity agonist BI167107, the high-affinity catecholamine agonist hydroxybenzyl isoproterenol, and the low-affinity endogenous agonist adrenaline. Catecholamines 165-178 adrenoceptor beta 2 Homo sapiens 53-60 23747301-1 2013 BACKGROUND: This study was designed to determine whether the cardiac ryanodine receptor (RyR2) central domain, a region associated with catecholamine polymorphic ventricular tachycardia (CPVT) mutations, interacts with the RyR2 regulators, ATP and the FK506-binding protein 12.6 (FKBP12.6). Catecholamines 136-149 ryanodine receptor 2 Homo sapiens 89-93 23747301-1 2013 BACKGROUND: This study was designed to determine whether the cardiac ryanodine receptor (RyR2) central domain, a region associated with catecholamine polymorphic ventricular tachycardia (CPVT) mutations, interacts with the RyR2 regulators, ATP and the FK506-binding protein 12.6 (FKBP12.6). Catecholamines 136-149 ryanodine receptor 2 Homo sapiens 223-227 23747301-1 2013 BACKGROUND: This study was designed to determine whether the cardiac ryanodine receptor (RyR2) central domain, a region associated with catecholamine polymorphic ventricular tachycardia (CPVT) mutations, interacts with the RyR2 regulators, ATP and the FK506-binding protein 12.6 (FKBP12.6). Catecholamines 136-149 FKBP prolyl isomerase 1B Homo sapiens 252-278 23747301-1 2013 BACKGROUND: This study was designed to determine whether the cardiac ryanodine receptor (RyR2) central domain, a region associated with catecholamine polymorphic ventricular tachycardia (CPVT) mutations, interacts with the RyR2 regulators, ATP and the FK506-binding protein 12.6 (FKBP12.6). Catecholamines 136-149 FKBP prolyl isomerase 1B Homo sapiens 280-288 24025224-1 2013 Bradykinin, acting via the bradykinin B2 receptor (B2R), is a potent stimulator of adrenomedullary catecholamine biosynthesis and release and likely plays an important role in the adrenomedullary stress response. Catecholamines 99-112 bradykinin receptor B2 Rattus norvegicus 51-54 24025224-10 2013 Overall, the increase in B2R gene expression in response to the stress-triggered rise in glucocorticoids likely enhances catecholamine biosynthesis and release and may serve as an adaptive response of the adrenomedullary catecholaminergic system to stress. Catecholamines 121-134 bradykinin receptor B2 Rattus norvegicus 25-28 23810893-7 2013 Chronic beta-AR stimulation via catecholamine infusions in rats enhanced PDE2 expression ~2-fold and cAMP hydrolytic activity ~4-fold, which correlated with blunted cardiac beta-AR responsiveness. Catecholamines 32-45 phosphodiesterase 2A Rattus norvegicus 73-77 24146652-8 2013 Under physiological conditions, the neuropeptide, alpha-calcitonin-related peptide, as well as catecholamines are the most-mentioned natural triggers for activating cAMP/PKA signaling in skeletal muscle. Catecholamines 95-109 cathelicidin antimicrobial peptide Homo sapiens 165-169 24106479-2 2013 Increased circulating catecholamine and activation of the different adrenergic receptors deployed in the various organs produce important metabolic responses which include: (1) increased lipolysis and elevated levels of fatty acids in plasma, (2) increased gluconeogenesis by the liver to provide substrate for the brain, and (3) moderate inhibition of insulin release by the pancreas to conserve glucose and to shift fuel metabolism of muscle in the direction of fatty acid oxidation. Catecholamines 22-35 insulin Homo sapiens 353-360 23562375-0 2013 Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla. Catecholamines 57-70 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 30-33 23904410-4 2013 This decrease is caused by accelerated Trp degradation, most likely induced by enhancement of the hepatic enzyme tryptophan 2,3-dioxygenase (TDO) by glucocorticoids and/or catecholamines. Catecholamines 172-186 tryptophan 2,3-dioxygenase Homo sapiens 113-139 23963054-0 2013 Growth hormone response to catecholamine depletion in unmedicated, remitted subjects with major depressive disorder and healthy controls. Catecholamines 27-40 growth hormone 1 Homo sapiens 0-14 23963054-1 2013 We investigated whether the human growth hormone (HGH) response to catecholamine depletion differs between fully remitted patients with major depressive disorder and healthy control subjects. Catecholamines 67-80 growth hormone 1 Homo sapiens 34-48 23904410-4 2013 This decrease is caused by accelerated Trp degradation, most likely induced by enhancement of the hepatic enzyme tryptophan 2,3-dioxygenase (TDO) by glucocorticoids and/or catecholamines. Catecholamines 172-186 tryptophan 2,3-dioxygenase Homo sapiens 141-144 24038935-0 2013 Rapid determination of catecholamines in urine samples by nonaqueous microchip electrophoresis with LIF detection. Catecholamines 23-37 LIF interleukin 6 family cytokine Homo sapiens 100-103 24038935-7 2013 The proposed NAMCE with LIF detection combined with a pump-free negative pressure sampling device is a simple, inexpensive, energy efficient, miniaturized system that can be successfully applied for the determination of catecholamines in urine samples. Catecholamines 220-234 LIF interleukin 6 family cytokine Homo sapiens 24-27 23722874-1 2013 We have recently reported that CD4(+) T cells synthesize and secrete catecholamines that facilitate a shift of T helper 1 (Th1)/Th2 balance toward Th2 polarization. Catecholamines 69-83 CD4 antigen Mus musculus 31-34 24228460-0 2013 [Low dose vasopressin is effective for catecholamine-resistant hypotension after resection of pheochromocytoma]. Catecholamines 39-52 arginine vasopressin Homo sapiens 10-21 23722874-1 2013 We have recently reported that CD4(+) T cells synthesize and secrete catecholamines that facilitate a shift of T helper 1 (Th1)/Th2 balance toward Th2 polarization. Catecholamines 69-83 heart and neural crest derivatives expressed 2 Mus musculus 128-131 23722874-1 2013 We have recently reported that CD4(+) T cells synthesize and secrete catecholamines that facilitate a shift of T helper 1 (Th1)/Th2 balance toward Th2 polarization. Catecholamines 69-83 heart and neural crest derivatives expressed 2 Mus musculus 147-150 23722874-2 2013 In this study, we used an animal model of human rheumatoid arthritis, collagen type II-induced arthritis (CIA), to explore relationship between catecholamine production in CD4(+) T cells and Th1-/Th2-mediated joint inflammation. Catecholamines 144-157 CD4 molecule Homo sapiens 172-175 23722874-2 2013 In this study, we used an animal model of human rheumatoid arthritis, collagen type II-induced arthritis (CIA), to explore relationship between catecholamine production in CD4(+) T cells and Th1-/Th2-mediated joint inflammation. Catecholamines 144-157 heart and neural crest derivatives expressed 2 Mus musculus 196-199 23722874-5 2013 Expression of tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of catecholamines, dramatically increased in ankle joints of CIA mice, although this increase was reduced on day 55 relative to that on day 35 post-immunization. Catecholamines 81-95 tyrosine hydroxylase Mus musculus 14-34 23722874-5 2013 Expression of tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of catecholamines, dramatically increased in ankle joints of CIA mice, although this increase was reduced on day 55 relative to that on day 35 post-immunization. Catecholamines 81-95 tyrosine hydroxylase Mus musculus 36-38 23722874-9 2013 The catecholamines are, at least in part, from Th1 and Th2 cells, and they may be related to joint inflammatory alleviation in CIA progression. Catecholamines 4-18 heart and neural crest derivatives expressed 2 Mus musculus 55-58 23333252-2 2013 To investigate the role of ghrelin and its considered counterpart, peptide tyrosine tyrosine (PYY), in the development of bulimic and depressive symptoms induced by catecholamine depletion, we administered the tyrosine hydroxylase inhibitor alpha-methyl-paratyrosine (AMPT) in a randomized, double-blind, placebo-controlled crossover, single-site experimental trial to 29 healthy controls and 20 subjects with fully recovered bulimia nervosa (rBN). Catecholamines 165-178 peptide YY Homo sapiens 67-92 23964689-3 2013 While it has been widely reported that renalase is the third monoamine oxidase (monoamine oxidase C) that oxidizes circulating catecholamines such as epinephrine, there has been no convincing demonstration of this catalysis in vitro. Catecholamines 127-141 renalase, FAD dependent amine oxidase Homo sapiens 39-47 23863468-1 2013 Renalase is a kidney-secreted catecholamines-degrading enzyme whose expression and activity are downregulated by increased dietary phosphate. Catecholamines 30-44 renalase, FAD-dependent amine oxidase Mus musculus 0-8 23964689-3 2013 While it has been widely reported that renalase is the third monoamine oxidase (monoamine oxidase C) that oxidizes circulating catecholamines such as epinephrine, there has been no convincing demonstration of this catalysis in vitro. Catecholamines 127-141 renalase, FAD dependent amine oxidase Homo sapiens 80-99 24058577-7 2013 However, beta-adrenergic blockade, but not glucocorticoids blockade, partially reversed the accumulation of CD11b+Gr1+ cells under the condition of chronic psychological stress, suggesting catecholamines collaborate with other factors to induce the accumulation. Catecholamines 189-203 integrin subunit alpha M Homo sapiens 108-113 23916146-0 2013 Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: virtual screening and functional testing identify novel small molecule therapeutics of hypertension. Catecholamines 45-58 chromogranin A Homo sapiens 86-96 23774690-1 2013 Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine. Catecholamines 52-66 catechol-O-methyltransferase Homo sapiens 0-28 23774690-1 2013 Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine. Catecholamines 52-66 catechol-O-methyltransferase Homo sapiens 30-34 24067174-2 2013 Numerous effects of exercise, both degree and duration, dietary change, illness, stress, mountain sickness, counter-regulatory hormones, and altitude increased sympathetic output, and catecholamines have led to conflicting accounts of insulin requirement increasing or decreasing at altitude. Catecholamines 184-198 insulin Homo sapiens 235-242 24174958-5 2013 Hg(2+) increases catecholamine levels through the inhibition of S-adenosylmethionine and subsequently catechol-O-methyltransferase (COMT), while a single nucleotide polymorphism of the COMT gene (rs769224) was recently found to be significantly associated with the development of coronary artery lesions in KS. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 102-130 24174958-5 2013 Hg(2+) increases catecholamine levels through the inhibition of S-adenosylmethionine and subsequently catechol-O-methyltransferase (COMT), while a single nucleotide polymorphism of the COMT gene (rs769224) was recently found to be significantly associated with the development of coronary artery lesions in KS. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 132-136 24174958-5 2013 Hg(2+) increases catecholamine levels through the inhibition of S-adenosylmethionine and subsequently catechol-O-methyltransferase (COMT), while a single nucleotide polymorphism of the COMT gene (rs769224) was recently found to be significantly associated with the development of coronary artery lesions in KS. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 185-189 24244869-9 2013 In conclusion, cardiac remodeling following catecholamine overactivation is modulated by FGF2 in isoform- and sex-specific manners. Catecholamines 44-57 fibroblast growth factor 2 Homo sapiens 89-93 23333252-2 2013 To investigate the role of ghrelin and its considered counterpart, peptide tyrosine tyrosine (PYY), in the development of bulimic and depressive symptoms induced by catecholamine depletion, we administered the tyrosine hydroxylase inhibitor alpha-methyl-paratyrosine (AMPT) in a randomized, double-blind, placebo-controlled crossover, single-site experimental trial to 29 healthy controls and 20 subjects with fully recovered bulimia nervosa (rBN). Catecholamines 165-178 peptide YY Homo sapiens 94-97 23701723-1 2013 The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions, including pain perception. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 11-39 22564389-14 2013 CONCLUSIONS: Erbin mediates catecholamine-induced beta2-AR/Her2 complexation and promotes catecholamine-induced activation of ERK signaling in cardiomyocytes, conferring protection of cardiomyocytes from apoptosis induced by chronic catecholamine stimulation. Catecholamines 28-41 erbb2 interacting protein Rattus norvegicus 13-18 22564389-14 2013 CONCLUSIONS: Erbin mediates catecholamine-induced beta2-AR/Her2 complexation and promotes catecholamine-induced activation of ERK signaling in cardiomyocytes, conferring protection of cardiomyocytes from apoptosis induced by chronic catecholamine stimulation. Catecholamines 28-41 adrenoceptor beta 2 Rattus norvegicus 50-58 22564389-14 2013 CONCLUSIONS: Erbin mediates catecholamine-induced beta2-AR/Her2 complexation and promotes catecholamine-induced activation of ERK signaling in cardiomyocytes, conferring protection of cardiomyocytes from apoptosis induced by chronic catecholamine stimulation. Catecholamines 90-103 erbb2 interacting protein Rattus norvegicus 13-18 22564389-14 2013 CONCLUSIONS: Erbin mediates catecholamine-induced beta2-AR/Her2 complexation and promotes catecholamine-induced activation of ERK signaling in cardiomyocytes, conferring protection of cardiomyocytes from apoptosis induced by chronic catecholamine stimulation. Catecholamines 90-103 Eph receptor B1 Rattus norvegicus 126-129 22564389-14 2013 CONCLUSIONS: Erbin mediates catecholamine-induced beta2-AR/Her2 complexation and promotes catecholamine-induced activation of ERK signaling in cardiomyocytes, conferring protection of cardiomyocytes from apoptosis induced by chronic catecholamine stimulation. Catecholamines 90-103 erbb2 interacting protein Rattus norvegicus 13-18 22564389-14 2013 CONCLUSIONS: Erbin mediates catecholamine-induced beta2-AR/Her2 complexation and promotes catecholamine-induced activation of ERK signaling in cardiomyocytes, conferring protection of cardiomyocytes from apoptosis induced by chronic catecholamine stimulation. Catecholamines 90-103 Eph receptor B1 Rattus norvegicus 126-129 23949217-9 2013 Furthermore, the arterial blood pressure and plasma catecholamine levels of CHL1(-/-) mice were also significantly higher than those of CHL1(+/+) mice. Catecholamines 52-65 cell adhesion molecule L1-like Mus musculus 76-80 23849528-2 2013 The postreperfusion syndrome has clearly defined and typically responds to vasopressin and/or methylene blue when refractory to catecholamine therapy. Catecholamines 128-141 arginine vasopressin Homo sapiens 75-86 23943425-0 2013 Rapid determination of catecholamines in urine samples by nonaqueous microchip electrophoresis with LIF detection. Catecholamines 23-37 LIF interleukin 6 family cytokine Homo sapiens 100-103 23943425-1 2013 A method was developed for the rapid separation of catecholamines by nonaqueous microchip electrophoresis with LIF detection, A homemade pump-free negative pressure sampling device was used for rapid bias-free sampling in nonaqueous microchip electrophoresis, the injection time was 0.5 s and the electrophoresis separation conditions were optimized. Catecholamines 51-65 LIF interleukin 6 family cytokine Homo sapiens 111-114 23747840-5 2013 Forskolin, stimulating cAMP, also induced co-secretion of Abeta peptides with peptide and catecholamine neurotransmitters. Catecholamines 90-103 amyloid beta precursor protein Homo sapiens 58-63 23701723-1 2013 The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions, including pain perception. Catecholamines 59-72 catechol-O-methyltransferase Homo sapiens 41-45 23747840-7 2013 Indeed, Abeta was demonstrated to be present in DCSV with neuropeptide and catecholamine transmitters. Catecholamines 75-88 amyloid beta precursor protein Homo sapiens 8-13 23718987-2 2013 Accumulating evidence suggests that interleukin (IL)-6 also plays a role in CRPS, and that catecholamines stimulate production of IL-6 in several tissues. Catecholamines 91-105 interleukin 6 Rattus norvegicus 130-134 23898865-1 2013 BACKGROUND: Phenylalanine hydroxylase (PAH) is the enzyme that metabolizes phenylalanine, an essential amino acid required for catecholamine synthesis. Catecholamines 127-140 phenylalanine hydroxylase Homo sapiens 12-37 23182292-5 2013 Glucocorticoids and catecholamines released by hypothalamic-pituitary-adrenal axis during stress will alter the balance Th1/Th2 and the balance Th17/Treg. Catecholamines 20-34 negative elongation factor complex member C/D Homo sapiens 120-123 23747840-11 2013 These findings illustrate that Abeta peptides are present in neurotransmitter-containing DCSV, and undergo co-secretion with neuropeptide and catecholamine neurotransmitters that regulate brain functions. Catecholamines 142-155 amyloid beta precursor protein Homo sapiens 31-36 23688154-1 2013 OBJECTIVES: Catestatin (CST) is a new endogenous neuropeptide with a potent catecholamine release-inhibitory activity. Catecholamines 76-89 chromogranin A Homo sapiens 12-22 23688154-1 2013 OBJECTIVES: Catestatin (CST) is a new endogenous neuropeptide with a potent catecholamine release-inhibitory activity. Catecholamines 76-89 chromogranin A Homo sapiens 24-27 23898865-1 2013 BACKGROUND: Phenylalanine hydroxylase (PAH) is the enzyme that metabolizes phenylalanine, an essential amino acid required for catecholamine synthesis. Catecholamines 127-140 phenylalanine hydroxylase Homo sapiens 39-42 23624627-5 2013 For example, chronic catecholamine stimulation induces cardiomyopathy, which is more severe in AC5-Tg mice, mediated through the AC5/sirtuin 1/forkhead box O3a pathway. Catecholamines 21-34 adenylate cyclase 5 Mus musculus 95-98 23624627-5 2013 For example, chronic catecholamine stimulation induces cardiomyopathy, which is more severe in AC5-Tg mice, mediated through the AC5/sirtuin 1/forkhead box O3a pathway. Catecholamines 21-34 adenylate cyclase 5 Mus musculus 129-132 23624627-5 2013 For example, chronic catecholamine stimulation induces cardiomyopathy, which is more severe in AC5-Tg mice, mediated through the AC5/sirtuin 1/forkhead box O3a pathway. Catecholamines 21-34 sirtuin 1 Mus musculus 133-142 23624627-6 2013 Conversely, disrupting AC5, i.e., AC5 knockout, protects the heart from chronic catecholamine cardiomyopathy as well as the cardiomyopathies resulting from chronic pressure overload or aging. Catecholamines 80-93 adenylate cyclase 5 Mus musculus 23-26 23624627-6 2013 Conversely, disrupting AC5, i.e., AC5 knockout, protects the heart from chronic catecholamine cardiomyopathy as well as the cardiomyopathies resulting from chronic pressure overload or aging. Catecholamines 80-93 adenylate cyclase 5 Mus musculus 34-37 23579242-5 2013 In these cell types, the catecholamine-mediated apoptosis is abrogated by loss of Bim. Catecholamines 25-38 BCL2 like 11 Homo sapiens 82-85 23647001-0 2013 The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain. Catecholamines 36-50 tyrosine hydroxylase Homo sapiens 86-106 23647001-7 2013 Our data demonstrate that BH4 and catecholamines are required for the post-natal augmentation of TH protein in the brain, and suggest that BH4 availability in early post-natal period is critical for the developmental regulation of TH protein level. Catecholamines 34-48 tyrosine hydroxylase Homo sapiens 97-99 23647001-7 2013 Our data demonstrate that BH4 and catecholamines are required for the post-natal augmentation of TH protein in the brain, and suggest that BH4 availability in early post-natal period is critical for the developmental regulation of TH protein level. Catecholamines 34-48 tyrosine hydroxylase Homo sapiens 231-233 22665263-7 2013 In the main meta-analysis, OCD was associated with serotonin-related polymorphisms (5-HTTLPR and HTR2A) and, in males only, with polymorphisms involved in catecholamine modulation (COMT and MAOA). Catecholamines 155-168 catechol-O-methyltransferase Homo sapiens 181-185 23772221-0 2013 Angiotensin AT1 - alpha2C-Adrenoceptor Interaction Disturbs alpha2A-auto-Inhibition of Catecholamine Release in Hypertensive Rats. Catecholamines 87-100 angiotensin II receptor, type 1a Rattus norvegicus 12-15 23416088-2 2013 Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover. Catecholamines 37-50 dopamine beta-hydroxylase Homo sapiens 0-25 23416088-2 2013 Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover. Catecholamines 37-50 dopamine beta-hydroxylase Homo sapiens 27-30 23470280-6 2013 These findings suggest that catecholamine and CRF enhancement of glutamatergic transmission onto CeAL neurons occurs via distinct mechanisms. Catecholamines 28-41 CEA cell adhesion molecule 6 Homo sapiens 97-101 23772221-0 2013 Angiotensin AT1 - alpha2C-Adrenoceptor Interaction Disturbs alpha2A-auto-Inhibition of Catecholamine Release in Hypertensive Rats. Catecholamines 87-100 adrenoceptor alpha 2C Rattus norvegicus 18-38 23772221-1 2013 alpha2-Adrenoceptors lower central sympathetic output and peripheral catecholamine release, and thus may prevent sympathetic hyperactivity and hypertension. Catecholamines 69-82 adrenoceptor alpha 2A Rattus norvegicus 0-20 23489141-1 2013 BACKGROUND AND PURPOSE: PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. Catecholamines 72-86 phosphodiesterase 4A Homo sapiens 36-40 21984048-1 2013 In the setting of acute myocardial infarction, hyperglycemia and acute insulin resistance may represent a stress response to myocardial injury mainly related to acute catecholamine release. Catecholamines 167-180 insulin Homo sapiens 71-78 23489196-6 2013 Furthermore, selective PDE4 inhibitors augment catecholamine-stimulated cAMP levels and induce arrhythmias in human atrial preparations, which suggests that PDE4 has a more prominent role in the human heart than anticipated, and that PDE4 inhibitors such as roflumilast may carry an arrhythmogenic risk. Catecholamines 47-60 phosphodiesterase 4A Homo sapiens 23-27 23489196-6 2013 Furthermore, selective PDE4 inhibitors augment catecholamine-stimulated cAMP levels and induce arrhythmias in human atrial preparations, which suggests that PDE4 has a more prominent role in the human heart than anticipated, and that PDE4 inhibitors such as roflumilast may carry an arrhythmogenic risk. Catecholamines 47-60 phosphodiesterase 4A Homo sapiens 157-161 23489196-6 2013 Furthermore, selective PDE4 inhibitors augment catecholamine-stimulated cAMP levels and induce arrhythmias in human atrial preparations, which suggests that PDE4 has a more prominent role in the human heart than anticipated, and that PDE4 inhibitors such as roflumilast may carry an arrhythmogenic risk. Catecholamines 47-60 phosphodiesterase 4A Homo sapiens 157-161 23630346-11 2013 Our data indicated a novel trastuzumab resistance mechanism, by which catecholamine-induced beta2-AR activation mediates desensitization of gastric cancer cells to trastuzumab through upregulating the MUC4 expression. Catecholamines 70-83 adrenoceptor beta 2 Homo sapiens 92-100 23946762-2 2013 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 57-70 tyrosine hydroxylase Homo sapiens 0-20 23946762-2 2013 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 57-70 tyrosine hydroxylase Homo sapiens 22-24 23946762-6 2013 Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Catecholamines 68-81 chromogranin A Homo sapiens 0-14 23946762-6 2013 Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Catecholamines 68-81 chromogranin A Homo sapiens 16-20 23630346-0 2013 Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. Catecholamines 0-13 adrenoceptor beta 2 Homo sapiens 22-47 23630346-0 2013 Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. Catecholamines 0-13 mucin 4, cell surface associated Homo sapiens 139-143 23630346-4 2013 Our in vitro data show that activation of beta2-adrenergic receptor (beta2-AR) triggered by catecholamine caused "targeting failure" of trastuzumab in gastric cancer cells. Catecholamines 92-105 adrenoceptor beta 2 Homo sapiens 42-67 23630346-4 2013 Our in vitro data show that activation of beta2-adrenergic receptor (beta2-AR) triggered by catecholamine caused "targeting failure" of trastuzumab in gastric cancer cells. Catecholamines 92-105 adrenoceptor beta 2 Homo sapiens 69-77 23630346-6 2013 Mechanistically, catecholamine induced upregulation of the MUC4 expression at both transcription and protein levels via activating STAT3 and ERK. Catecholamines 17-30 mucin 4, cell surface associated Homo sapiens 59-63 23630346-6 2013 Mechanistically, catecholamine induced upregulation of the MUC4 expression at both transcription and protein levels via activating STAT3 and ERK. Catecholamines 17-30 signal transducer and activator of transcription 3 Homo sapiens 131-136 23630346-6 2013 Mechanistically, catecholamine induced upregulation of the MUC4 expression at both transcription and protein levels via activating STAT3 and ERK. Catecholamines 17-30 mitogen-activated protein kinase 1 Homo sapiens 141-144 23630346-7 2013 The effects of catecholamine could be effectively blocked by beta2-AR antagonist ICI-118,551, indicating that beta2-AR-mediated signaling pathway plays a key role in upregulation of MUC4, which was previously demonstrated to interfere with the recognition and physical binding of trastuzumab to Her2 molecules. Catecholamines 15-28 adrenoceptor beta 2 Homo sapiens 61-69 23630346-7 2013 The effects of catecholamine could be effectively blocked by beta2-AR antagonist ICI-118,551, indicating that beta2-AR-mediated signaling pathway plays a key role in upregulation of MUC4, which was previously demonstrated to interfere with the recognition and physical binding of trastuzumab to Her2 molecules. Catecholamines 15-28 adrenoceptor beta 2 Homo sapiens 110-118 23630346-7 2013 The effects of catecholamine could be effectively blocked by beta2-AR antagonist ICI-118,551, indicating that beta2-AR-mediated signaling pathway plays a key role in upregulation of MUC4, which was previously demonstrated to interfere with the recognition and physical binding of trastuzumab to Her2 molecules. Catecholamines 15-28 mucin 4, cell surface associated Homo sapiens 182-186 23630346-7 2013 The effects of catecholamine could be effectively blocked by beta2-AR antagonist ICI-118,551, indicating that beta2-AR-mediated signaling pathway plays a key role in upregulation of MUC4, which was previously demonstrated to interfere with the recognition and physical binding of trastuzumab to Her2 molecules. Catecholamines 15-28 erb-b2 receptor tyrosine kinase 2 Homo sapiens 295-299 23351565-2 2013 COMT enzyme participates in metabolic pathways involving brain catecholamines, as well as steroid hormones such as estrogens. Catecholamines 63-77 catechol-O-methyltransferase Homo sapiens 0-4 23630346-11 2013 Our data indicated a novel trastuzumab resistance mechanism, by which catecholamine-induced beta2-AR activation mediates desensitization of gastric cancer cells to trastuzumab through upregulating the MUC4 expression. Catecholamines 70-83 mucin 4, cell surface associated Homo sapiens 201-205 23475824-1 2013 Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. Catecholamines 63-76 catechol-O-methyltransferase Homo sapiens 0-28 23434467-3 2013 PATIENTS AND METHOD: Genetic study by PCR-direct sequencing SDHB gene and biochemical determination in blood/urine fractionated catecholamine 24h, metanephrines and conventional (computed tomography/magnetic resonance imaging) and functional imaging ((123)I-MIBG) in all members of a family diagnosed of PGL. Catecholamines 128-141 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 60-64 23388515-11 2013 After hexamethonium treatment, it was found that the acute hypertension induced by 6-hydroxydopamine lesions was immediately reversed and the acute high rise of catecholamine serum level was significantly attenuated within 3 hours, accompanied by preserved cardiac output and decreased expressions of connexin 43 in the heart and lungs. Catecholamines 161-174 gap junction protein, alpha 1 Rattus norvegicus 301-312 23443926-2 2013 This has led to the hypothesis that the increases in PGC-1alpha and mitochondrial biogenesis induced in muscle by endurance exercise are mediated by catecholamines. Catecholamines 149-163 PPARG coactivator 1 alpha Rattus norvegicus 53-63 23454381-5 2013 Our results indicate that inhibition of beta-adrenoceptor-mediated Ca(2+) elevation by alpha1-adrenoceptor-PTK signaling serves as an important regulatory feedback mechanism when the catecholamine level increases to protect cardiomyocytes from cytosolic Ca(2+) overload. Catecholamines 183-196 adrenoceptor alpha 1D Homo sapiens 87-93 23454381-5 2013 Our results indicate that inhibition of beta-adrenoceptor-mediated Ca(2+) elevation by alpha1-adrenoceptor-PTK signaling serves as an important regulatory feedback mechanism when the catecholamine level increases to protect cardiomyocytes from cytosolic Ca(2+) overload. Catecholamines 183-196 protein tyrosine kinase 2 beta Homo sapiens 107-110 22762393-6 2013 TH is the first enzyme in catecholamine biosynthesis; it is a useful maker for all cells involved with catecholamine biosynthesis including chromaffin cells. Catecholamines 26-39 tyrosine hydroxylase Canis lupus familiaris 0-2 23537934-1 2013 Tyrosine hydroxylase (TH) catalyses the rate-limiting step in the biosynthesis of catecholamines. Catecholamines 82-96 tyrosine hydroxylase Homo sapiens 0-20 23537934-1 2013 Tyrosine hydroxylase (TH) catalyses the rate-limiting step in the biosynthesis of catecholamines. Catecholamines 82-96 tyrosine hydroxylase Homo sapiens 22-24 23537934-3 2013 Because of its key regulatory role in central and peripheral catecholamine synthesis, TH is associated with the pathogenesis of several neurological and psychiatric diseases, including Parkinson"s disease, dystonia, schizophrenia, affective disorders, and cardiovascular diseases. Catecholamines 61-74 tyrosine hydroxylase Homo sapiens 86-88 23667629-7 2013 These results suggest that FGF21 may also be associated with exercise-induced lipolysis in addition to increased catecholamines and reduced insulin. Catecholamines 113-127 fibroblast growth factor 21 Mus musculus 27-32 23940951-11 2013 CONCLUSION: CD4+ T lymphocytes up-regulate TH expression in the process of CIA and therefore, it is suggested that endogenous catecholamines of lymphocytes involve in the pathogenesis of RA. Catecholamines 126-140 tyrosine hydroxylase Mus musculus 43-45 23536361-7 2013 CONCLUSIONS: Overexpression of AC5 exacerbates the cardiomyopathy induced by chronic catecholamine stress by altering regulation of SIRT1/FoxO3a, MEK/ERK, and MnSOD, resulting in oxidative stress intolerance, thereby shedding light on new approaches for treatment of heart failure. Catecholamines 85-98 adenylate cyclase 5 Mus musculus 31-34 23202349-2 2013 In the present study, plasmid constructs containing green fluorescent protein (GFP) and the promoter of tyrosine hydroxylase (TH), a key synthetic enzyme for catecholamines, were produced. Catecholamines 158-172 tyrosine hydroxylase Danio rerio 104-124 23202349-2 2013 In the present study, plasmid constructs containing green fluorescent protein (GFP) and the promoter of tyrosine hydroxylase (TH), a key synthetic enzyme for catecholamines, were produced. Catecholamines 158-172 tyrosine hydroxylase Danio rerio 126-128 23613951-1 2013 The catechol-O-methyltransferase (COMT) enzyme metabolises catecholamines. Catecholamines 59-73 catechol-O-methyltransferase Rattus norvegicus 4-32 23613951-1 2013 The catechol-O-methyltransferase (COMT) enzyme metabolises catecholamines. Catecholamines 59-73 catechol-O-methyltransferase Rattus norvegicus 34-38 23434582-0 2013 Endothelin-1-induced down-regulation of NaV1.7 expression in adrenal chromaffin cells: attenuation of catecholamine secretion and tau dephosphorylation. Catecholamines 102-115 endothelin 1 Homo sapiens 0-12 23434582-0 2013 Endothelin-1-induced down-regulation of NaV1.7 expression in adrenal chromaffin cells: attenuation of catecholamine secretion and tau dephosphorylation. Catecholamines 102-115 sodium voltage-gated channel alpha subunit 9 Homo sapiens 40-46 23434582-2 2013 We previously demonstrated that veratridine-induced NaV1.7 sodium channel activation caused intracellular calcium elevation, catecholamine secretion and tau dephosphorylation in adrenal chromaffin cells. Catecholamines 125-138 sodium voltage-gated channel alpha subunit 9 Homo sapiens 52-58 23434582-6 2013 These findings suggest that the endothelin-1-induced down-regulation of NaV1.7 diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau. Catecholamines 105-118 endothelin 1 Homo sapiens 32-44 23434582-6 2013 These findings suggest that the endothelin-1-induced down-regulation of NaV1.7 diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau. Catecholamines 105-118 sodium voltage-gated channel alpha subunit 9 Homo sapiens 72-78 23434582-6 2013 These findings suggest that the endothelin-1-induced down-regulation of NaV1.7 diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau. Catecholamines 105-118 neuron navigator 1 Homo sapiens 72-76 23499051-10 2013 The production of IL-17s required activation of c-Jun-N-terminal kinase, which was antagonized by both catecholamines and glucocorticoids. Catecholamines 103-117 interleukin 17A Mus musculus 18-23 23329127-1 2013 The flavocytochrome cellobiose dehydrogenase (CDH) is a versatile biorecognition element capable of detecting carbohydrates as well as quinones and catecholamines. Catecholamines 148-162 choline dehydrogenase Homo sapiens 20-44 23329127-1 2013 The flavocytochrome cellobiose dehydrogenase (CDH) is a versatile biorecognition element capable of detecting carbohydrates as well as quinones and catecholamines. Catecholamines 148-162 choline dehydrogenase Homo sapiens 46-49 22762393-6 2013 TH is the first enzyme in catecholamine biosynthesis; it is a useful maker for all cells involved with catecholamine biosynthesis including chromaffin cells. Catecholamines 103-116 tyrosine hydroxylase Canis lupus familiaris 0-2 22969162-3 2013 Renalase may play an important role in the control of blood pressure (BP) by its regulatory function of catecholamine metabolism. Catecholamines 104-117 renalase, FAD dependent amine oxidase Homo sapiens 0-8 23475824-1 2013 Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. Catecholamines 63-76 catechol-O-methyltransferase Homo sapiens 30-34 23481708-3 2013 We studied the expression of tyrosine hydroxylase (TH), the first and rate-limiting enzyme in catecholamine synthesis, in substantia nigra, and ventral tegmental area of 18 neonates in relation to the age and severity/duration of hypoxic injury estimated by neuropathological criteria. Catecholamines 94-107 tyrosine hydroxylase Homo sapiens 29-49 22948026-2 2013 Carriers of germline mutations in the SDHB or SDHD genes may develop parasympathetic paragangliomas in the head and neck region or sympathetic catecholamine-secreting abdominal and thoracic paragangliomas (pheochromocytomas). Catecholamines 143-156 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 38-42 23481708-3 2013 We studied the expression of tyrosine hydroxylase (TH), the first and rate-limiting enzyme in catecholamine synthesis, in substantia nigra, and ventral tegmental area of 18 neonates in relation to the age and severity/duration of hypoxic injury estimated by neuropathological criteria. Catecholamines 94-107 tyrosine hydroxylase Homo sapiens 51-53 23531330-12 2013 CONCLUSIONS: Our study concluded that ritonavir, a nonspecific GLUT inhibitors showed complete protection in catecholamine induced myocardial necrosis. Catecholamines 109-122 solute carrier family 1 (glial high affinity glutamate transporter), member 3 Mus musculus 63-67 23621023-1 2013 Tyrosine hydroxylase, the rate-limiting enzyme of catecholamine biosysthesis, is predominantly expressed in several cell groups within the brain, including the dopaminergic neurons of the substantia nigra and ventral tegmental area. Catecholamines 50-63 tyrosine hydroxylase Homo sapiens 0-20 26835675-11 2013 Here, we review findings relating to an early diagnostic marker for detecting degeneration of the peripheral sympathetic nerves, and propose the hypothesis that catecholamines cause alpha-synuclein to aggregate and play an important role in disease pathogenesis. Catecholamines 161-175 synuclein alpha Homo sapiens 182-197 23506497-10 2013 The first line vasopressor recommended at present is norepinephrine, while vasopressin can be started as a salvage therapy for those not responding to catecholamines. Catecholamines 151-165 arginine vasopressin Homo sapiens 75-86 26835675-0 2013 Catecholamines and Neurodegeneration in Parkinson"s Disease-From Diagnostic Marker to Aggregations of alpha-Synuclein. Catecholamines 0-14 synuclein alpha Homo sapiens 102-117 23270608-6 2013 We then measured immunolabeling for phosphorylated tyrosine hydroxylase (pTH-ir), the rate-limiting enzyme for catecholamine synthesis, in brain regions in which catecholamines stimulate agonistic behavior. Catecholamines 111-124 parathyroid hormone Sturnus vulgaris 73-76 23270608-6 2013 We then measured immunolabeling for phosphorylated tyrosine hydroxylase (pTH-ir), the rate-limiting enzyme for catecholamine synthesis, in brain regions in which catecholamines stimulate agonistic behavior. Catecholamines 162-176 parathyroid hormone Sturnus vulgaris 73-76 23318885-7 2013 The role of soluble factors elicited by catecholamines seemed pleiotropic as VEGF synergized with NE increased melanoma invasiveness through 3D barriers, while IL-6 participated in stromal fibroblast activation towards a myofibroblastic phenotype. Catecholamines 40-54 vascular endothelial growth factor A Homo sapiens 77-81 23180813-4 2013 We hypothesized that adrenal hormones affect the production of tumour necrosis factor-alpha (TNF-alpha) and NO by macrophages by altering the modulatory influence of catecholamines. Catecholamines 166-180 tumor necrosis factor Rattus norvegicus 93-102 23180813-8 2013 The expression of beta2-adrenoceptor was increased in peritoneal macrophages that were freshly isolated from non-operated, propranolol-treated and adrenalectomized rats (due to adrenal catecholamine deficiency). Catecholamines 185-198 adrenoceptor beta 2 Rattus norvegicus 18-36 22290536-8 2013 In addition, enhanced IL-6 promoter activity can be similarly induced by ET-1 and catecholamines (epinephrine and norepinephrine). Catecholamines 82-96 interleukin 6 Mus musculus 22-26 23477980-3 2013 Vasopressin has also been studied on a limited basis for use in the treatment of catecholamine-resistant hypotension in vasodilatory shock. Catecholamines 81-94 arginine vasopressin Homo sapiens 0-11 23433357-14 2013 CONCLUSIONS: In STEMI patients treated with pPCI, catecholamines correlated weakly with biomarkers of endothelial damage, with the strongest correlations and highest adrenaline and syndecan-1 levels in patients with shock. Catecholamines 50-64 syndecan 1 Homo sapiens 181-191 23224983-6 2013 We measured catecholamine metabolites affected by DBH via high-performance liquid chromatography with electrochemical detection, and assessed brain histopathology. Catecholamines 12-25 dopamine beta hydroxylase Mus musculus 50-53 23246742-1 2013 AIMS: Tyrosine hydroxylase (TH) and GTP cyclohydrolase I (GCH) are the rate-limiting enzymes for the biosynthesis of catecholamines and tetrahydrobiopterin (BH4), respectively. Catecholamines 117-131 tyrosine hydroxylase Homo sapiens 6-26 23246742-1 2013 AIMS: Tyrosine hydroxylase (TH) and GTP cyclohydrolase I (GCH) are the rate-limiting enzymes for the biosynthesis of catecholamines and tetrahydrobiopterin (BH4), respectively. Catecholamines 117-131 tyrosine hydroxylase Homo sapiens 28-30 23246742-1 2013 AIMS: Tyrosine hydroxylase (TH) and GTP cyclohydrolase I (GCH) are the rate-limiting enzymes for the biosynthesis of catecholamines and tetrahydrobiopterin (BH4), respectively. Catecholamines 117-131 GTP cyclohydrolase 1 Homo sapiens 36-56 23246742-1 2013 AIMS: Tyrosine hydroxylase (TH) and GTP cyclohydrolase I (GCH) are the rate-limiting enzymes for the biosynthesis of catecholamines and tetrahydrobiopterin (BH4), respectively. Catecholamines 117-131 GTP cyclohydrolase 1 Homo sapiens 58-61 23439212-1 2013 Vasopressin and its analogue terlipressin are potent vasopressors which have been recently proposed in the treatment of catecholamine-resistant septic shock. Catecholamines 120-133 arginine vasopressin Homo sapiens 0-11 23439212-5 2013 Nevertheless, low doses of vasopressin and terlipressin seem to have the potential to restore vasomotor tone in conditions refractory to catecholamines, improving organ perfusion with preservation of renal blood flow, while decreasing catecholamine requirements. Catecholamines 137-151 arginine vasopressin Homo sapiens 27-38 23439212-5 2013 Nevertheless, low doses of vasopressin and terlipressin seem to have the potential to restore vasomotor tone in conditions refractory to catecholamines, improving organ perfusion with preservation of renal blood flow, while decreasing catecholamine requirements. Catecholamines 137-150 arginine vasopressin Homo sapiens 27-38 22290536-14 2013 SIGNIFICANCE: This study should provide a new perspective for treating IL-6-related diseases, especially those accompanied with elevated ET-1 and catecholamine levels. Catecholamines 146-159 interleukin 6 Mus musculus 71-75 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 0-28 23393318-2 2013 Renalase, an amine oxidase secreted by the proximal tubule, degrades circulating catecholamines and reduces myocardial necrosis, suggesting that it may protect against renal ischemia reperfusion injury. Catecholamines 81-95 renalase, FAD-dependent amine oxidase Mus musculus 0-8 23393318-5 2013 Furthermore, renal tubular inflammation, necrosis, and apoptosis were more severe and plasma catecholamine levels were higher in renalase-deficient mice subjected to renal ischemia reperfusion compared with wild-type mice. Catecholamines 93-106 renalase, FAD-dependent amine oxidase Mus musculus 129-137 23393318-6 2013 Administration of recombinant human renalase reduced plasma catecholamine levels and ameliorated ischemic AKI in wild-type mice. Catecholamines 60-73 renalase, FAD dependent amine oxidase Homo sapiens 36-44 23124944-1 2013 Intravenous application of catecholamines produces a depression in the endolymphatic sac direct current potential (ESP) and increases endolymphatic pressure via the beta-adrenergic receptor (AR) in guinea pigs, suggesting that catecholamines play a role in the endolymphatic system. Catecholamines 27-41 protein tyrosine phosphatase, receptor type, V Rattus norvegicus 115-118 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 30-34 23153692-4 2013 These results show that phosphorylation of TH at Ser31 and Ser40 is increased in CB glomus cells by short-term hypoxia, suggesting that activation of TH via phosphorylation contributes to the facilitation of catecholamine biosynthesis in CB glomus cells at an early stage of hypoxia. Catecholamines 208-221 tyrosine hydroxylase Rattus norvegicus 43-45 23069677-6 2013 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the synthesis of catecholamines; and the TH level was used to assess by inference, NE output. Catecholamines 75-89 tyrosine hydroxylase Homo sapiens 0-20 23069677-6 2013 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the synthesis of catecholamines; and the TH level was used to assess by inference, NE output. Catecholamines 75-89 tyrosine hydroxylase Homo sapiens 22-24 23184041-1 2013 The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 89-103 catechol-O-methyltransferase Homo sapiens 20-47 23184041-1 2013 The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 89-103 catechol-O-methyltransferase Homo sapiens 49-53 22212595-0 2013 Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels. Catecholamines 86-99 amyloid beta (A4) precursor protein Mus musculus 26-56 22212595-2 2013 The expression of beta-amyloid precursor protein (APP) is responsive to stress and is high in tissues rich in catecholamines. Catecholamines 110-124 amyloid beta (A4) precursor protein Mus musculus 18-48 23184347-6 2013 Herein, we present an approach to identify potential substrates for previously uncharacterized members of the Gcn5-related acetyltransferase superfamily using a variety of metabolites including polyamines, amino acids, antibiotics, peptides, vitamins, catecholamines, and other metabolites. Catecholamines 252-266 lysine acetyltransferase 2A Homo sapiens 110-114 23153692-4 2013 These results show that phosphorylation of TH at Ser31 and Ser40 is increased in CB glomus cells by short-term hypoxia, suggesting that activation of TH via phosphorylation contributes to the facilitation of catecholamine biosynthesis in CB glomus cells at an early stage of hypoxia. Catecholamines 208-221 tyrosine hydroxylase Rattus norvegicus 150-152 23360571-4 2013 A primary retrocardiac paraganglioma catecholamine-productive was identified in an asymptomatic 49-year old female associated to familial pheochromocytoma-paraganglioma syndrome caused by germline mutation of the gen which codifies for the subunit B of succinate dehydrogenase enzyme (SDHB). Catecholamines 37-50 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 285-289 22997248-8 2013 In vivo, RSK3 gene deletion in the mouse attenuated the concentric myocyte hypertrophy induced by pressure overload and catecholamine infusion. Catecholamines 120-133 ribosomal protein S6 kinase, polypeptide 2 Mus musculus 9-13 23905079-1 2013 Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are potent alternative vasoconstrictors in the treatment of septic patients with catecholamine-refractive vasodilatatory shock. Catecholamines 164-177 arginine vasopressin Homo sapiens 9-20 24054150-6 2013 Moreover, current knowledge about tumor formation in cells of the sympathoadrenal lineage, leading to catecholamine-producing pheochromocytomas and paragangliomas, is analyzed in the light of the HIF2alpha signaling network. Catecholamines 102-115 endothelial PAS domain protein 1 Homo sapiens 196-205 23224879-5 2013 Under stress, catecholamine stimulation phosphorylates PLM at serine(68), resulting in relief of inhibition of Na(+)-K(+)-ATPase by decreasing K(m) for Na(+) and increasing V(max), and simultaneous inhibition of Na(+)/Ca(2+) exchanger. Catecholamines 14-27 FXYD domain containing ion transport regulator 1 Homo sapiens 55-58 23224879-5 2013 Under stress, catecholamine stimulation phosphorylates PLM at serine(68), resulting in relief of inhibition of Na(+)-K(+)-ATPase by decreasing K(m) for Na(+) and increasing V(max), and simultaneous inhibition of Na(+)/Ca(2+) exchanger. Catecholamines 14-27 solute carrier family 8 member A1 Homo sapiens 212-234 23603923-7 2013 In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. Catecholamines 64-77 bone morphogenetic protein 6 Homo sapiens 23-28 23603923-7 2013 In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. Catecholamines 64-77 bone morphogenetic protein 4 Homo sapiens 33-38 24054137-1 2013 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is a key protein involved in the pathogenesis of neurodegenerative diseases such as Parkinson"s disease. Catecholamines 75-89 tyrosine hydroxylase Homo sapiens 0-20 24054137-1 2013 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is a key protein involved in the pathogenesis of neurodegenerative diseases such as Parkinson"s disease. Catecholamines 75-89 tyrosine hydroxylase Homo sapiens 22-24 24054138-1 2013 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. Catecholamines 81-95 tyrosine hydroxylase Homo sapiens 0-20 24054138-1 2013 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. Catecholamines 81-95 tyrosine hydroxylase Homo sapiens 22-24 24054138-2 2013 In response to short-term stimuli, TH activity is regulated by feedback inhibition by the catecholamines and relief of that inhibition by phosphorylation. Catecholamines 90-104 tyrosine hydroxylase Homo sapiens 35-37 24054144-0 2013 Selective ablation of dopamine beta-hydroxylase neurons in the brain by immunotoxin-mediated neuronal targeting: new insights into brain catecholaminergic circuitry and catecholamine-related diseases. Catecholamines 137-150 dopamine beta-hydroxylase Homo sapiens 22-47 24054147-0 2013 Catecholamine metabolites affected by the copper-dependent enzyme dopamine-beta-hydroxylase provide sensitive biomarkers for early diagnosis of menkes disease and viral-mediated ATP7A gene therapy. Catecholamines 0-13 dopamine beta-hydroxylase Homo sapiens 66-91 24054147-0 2013 Catecholamine metabolites affected by the copper-dependent enzyme dopamine-beta-hydroxylase provide sensitive biomarkers for early diagnosis of menkes disease and viral-mediated ATP7A gene therapy. Catecholamines 0-13 ATPase copper transporting alpha Homo sapiens 178-183 24054157-3 2013 During direct high-frequency stimulation of the splanchnic nerve that is designed to mimic stress, PACAP regulates adrenomedullary catecholamine secretion. Catecholamines 131-144 adenylate cyclase activating polypeptide 1 Homo sapiens 99-104 24054157-4 2013 In addition to transmission, PACAP simultaneously facilitates the biosynthesis of adrenomedullary catecholamines through stimulus-secretion-synthesis coupling. Catecholamines 98-112 adenylate cyclase activating polypeptide 1 Homo sapiens 29-34 23484208-4 2013 Presumably, intensive accumulation of chromogranin A and secretory granules in chromaffin cells of hypertensive rats reflects a certain imbalance of chromogranin A and catecholamines biogenesis, this, in turn, leading to stable stimulation of the sympathoadrenal component and higher stress sensitivity of these animals. Catecholamines 168-182 chromogranin A Rattus norvegicus 38-52 22738763-0 2013 Deficiency of catecholamine syntheses caused by downregulation of phosphorylation of tyrosine hydroxylase in the cerebral cortex of the senescence-accelerated mouse prone 10 strain with aging. Catecholamines 14-27 tyrosine hydroxylase Mus musculus 85-105 24167357-4 2013 While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 6-34 24450388-1 2013 Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 140-154 catechol-O-methyltransferase Homo sapiens 0-28 24450388-1 2013 Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 140-154 catechol-O-methyltransferase Homo sapiens 30-34 23537088-4 2013 Nesfatin-1 shows extensive co-localization with various other, predominantly food intake inhibitory, hypothalamic peptides including corticotropin-releasing factor (CRF), oxytocin, cholecystokinin, proopiomelanocortin, -alphamelanocyte stimulating hormone (alpha-MSH), thyrotropin-releasing hormone (TRH), the orexigenic neuropeptide Y and brain biogenic amines, histamine, serotonin, and catecholamines. Catecholamines 389-403 nucleobindin 2 Rattus norvegicus 0-10 24167357-4 2013 While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 36-40 24167357-4 2013 While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 132-136 23509214-11 2013 The HO-1 inducer (i.e., hemin) significantly decreased catecholamines and corticosterone levels, and increased testosterone and LH levels. Catecholamines 55-69 heme oxygenase 1 Rattus norvegicus 4-8 23221599-0 2013 PACAP controls adrenomedullary catecholamine secretion and expression of catecholamine biosynthetic enzymes at high splanchnic nerve firing rates characteristic of stress transduction in male mice. Catecholamines 31-44 adenylate cyclase activating polypeptide 1 Mus musculus 0-5 23221599-0 2013 PACAP controls adrenomedullary catecholamine secretion and expression of catecholamine biosynthetic enzymes at high splanchnic nerve firing rates characteristic of stress transduction in male mice. Catecholamines 73-86 adenylate cyclase activating polypeptide 1 Mus musculus 0-5 23221599-2 2013 We have previously reported that survival of prolonged metabolic stress in mice requires PACAP-dependent biosynthesis and secretion of adrenomedullary catecholamines (CAs). Catecholamines 151-165 adenylate cyclase activating polypeptide 1 Mus musculus 89-94 23221599-2 2013 We have previously reported that survival of prolonged metabolic stress in mice requires PACAP-dependent biosynthesis and secretion of adrenomedullary catecholamines (CAs). Catecholamines 167-170 adenylate cyclase activating polypeptide 1 Mus musculus 89-94 24348550-8 2013 This study provides the following findings: (1) BAT surrounding PHEO expresses adiponectin and UCP-1 mRNA, (2) expression of adiponectin mRNA is significantly higher in BAT than in WAT surrounding PHEO, and (3) catecholamines and serum adiponectin levels significantly correlate with BAT UCP-1 and adiponectin mRNA. Catecholamines 211-225 adiponectin, C1Q and collagen domain containing Homo sapiens 125-136 24348550-8 2013 This study provides the following findings: (1) BAT surrounding PHEO expresses adiponectin and UCP-1 mRNA, (2) expression of adiponectin mRNA is significantly higher in BAT than in WAT surrounding PHEO, and (3) catecholamines and serum adiponectin levels significantly correlate with BAT UCP-1 and adiponectin mRNA. Catecholamines 211-225 adiponectin, C1Q and collagen domain containing Homo sapiens 125-136 24348550-8 2013 This study provides the following findings: (1) BAT surrounding PHEO expresses adiponectin and UCP-1 mRNA, (2) expression of adiponectin mRNA is significantly higher in BAT than in WAT surrounding PHEO, and (3) catecholamines and serum adiponectin levels significantly correlate with BAT UCP-1 and adiponectin mRNA. Catecholamines 211-225 adiponectin, C1Q and collagen domain containing Homo sapiens 125-136 22528689-2 2013 The purpose of the present study was to investigate the relationship of three common haplotypes of COMT gene affecting the metabolism of catecholamines on pain sensitivity in patients with fibromyalgia (FM). Catecholamines 137-151 catechol-O-methyltransferase Homo sapiens 99-103 23017014-2 2013 Catecholamine release was confirmed in vitro by stimulating chromaffin cells with recombinant BDNF. Catecholamines 0-13 brain-derived neurotrophic factor Rattus norvegicus 94-98 23017014-4 2013 Blood catecholamine levels increased after stimulation with TrkB expressed in the adrenal medulla during 60-min stress; however, blood catecholamine levels did not increase in adrenalectomized rats. Catecholamines 6-19 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 60-64 23017014-7 2013 These results suggest that signal transduction of TrkB in the adrenal medulla evokes catecholamine release. Catecholamines 85-98 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 50-54 23017014-8 2013 In addition, catecholamine release was evoked by both the hypothalamic-pituitary-adrenal axis and autocrine signaling by BDNF in the adrenal gland. Catecholamines 13-26 brain-derived neurotrophic factor Rattus norvegicus 121-125 23386378-7 2013 ), elevated basal plasma catecholamines with JZL184 (MGL inhibitor)- and indomethacin (cyclooxygenase inhibitor)-sensitive brain mechanisms. Catecholamines 25-39 monoglyceride lipase Rattus norvegicus 53-56 23095308-0 2013 Lymphocyte-derived catecholamines induce a shift of Th1/Th2 balance toward Th2 polarization. Catecholamines 19-33 negative elongation factor complex member C/D, Th1l Mus musculus 52-55 23095308-0 2013 Lymphocyte-derived catecholamines induce a shift of Th1/Th2 balance toward Th2 polarization. Catecholamines 19-33 heart and neural crest derivatives expressed 2 Mus musculus 56-59 23095308-0 2013 Lymphocyte-derived catecholamines induce a shift of Th1/Th2 balance toward Th2 polarization. Catecholamines 19-33 heart and neural crest derivatives expressed 2 Mus musculus 75-78 23095308-9 2013 CONCLUSION: CAs synthesized and secreted by lymphocytes regulate differentiation and function of Th cells, with an effect facilitating the shift of Th1/Th2 balance toward Th2 polarization. Catecholamines 12-15 negative elongation factor complex member C/D, Th1l Mus musculus 148-151 23095308-9 2013 CONCLUSION: CAs synthesized and secreted by lymphocytes regulate differentiation and function of Th cells, with an effect facilitating the shift of Th1/Th2 balance toward Th2 polarization. Catecholamines 12-15 heart and neural crest derivatives expressed 2 Mus musculus 152-155 23095308-9 2013 CONCLUSION: CAs synthesized and secreted by lymphocytes regulate differentiation and function of Th cells, with an effect facilitating the shift of Th1/Th2 balance toward Th2 polarization. Catecholamines 12-15 heart and neural crest derivatives expressed 2 Mus musculus 171-174 23108654-7 2012 These data suggest that, in DOCA-salt hypertension in mice, cytochrome P450 1B1 plays a pivotal role in cardiovascular dysfunction, renal damage, and inflammation, and increased levels of catecholamines, vasopressin, and endothelin-1, consequent to generation of reactive oxygen species and activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, and cellular-Src independent of eicosanoids. Catecholamines 188-202 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 60-79 23375328-1 2013 INTRODUCTION: Renalase, an enzyme that cetabolyzes catecholamines, such as circulating adrenaline and noradrenaline, is released by the human kidney to regulate blood pressure. Catecholamines 51-65 renalase, FAD dependent amine oxidase Homo sapiens 14-22 23054058-9 2012 The enhancement of catecholamine-induced lipolysis in inguinal and retroperitoneal adipocytes after 8 wk of AICAR treatment was accompanied by increased contents of adipose triglyceride lipase (ATGL) and perilipin A in these fat depots. Catecholamines 19-32 patatin-like phospholipase domain containing 2 Rattus norvegicus 165-192 23054058-9 2012 The enhancement of catecholamine-induced lipolysis in inguinal and retroperitoneal adipocytes after 8 wk of AICAR treatment was accompanied by increased contents of adipose triglyceride lipase (ATGL) and perilipin A in these fat depots. Catecholamines 19-32 patatin-like phospholipase domain containing 2 Rattus norvegicus 194-198 22999823-9 2012 Labeling for tyrosine hydroxylase (TH; the rate limiting enzyme for catecholamine synthesis) in putative nucleus accumbens was lowest in spring-like females without nest sites, and labeling correlated positively with nesting behavior in spring-like females. Catecholamines 68-81 tyrosine 3-monooxygenase Sturnus vulgaris 13-33 22999823-9 2012 Labeling for tyrosine hydroxylase (TH; the rate limiting enzyme for catecholamine synthesis) in putative nucleus accumbens was lowest in spring-like females without nest sites, and labeling correlated positively with nesting behavior in spring-like females. Catecholamines 68-81 tyrosine 3-monooxygenase Sturnus vulgaris 35-37 24145076-0 2013 Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro. Catecholamines 86-99 thyrotropin releasing hormone Rattus norvegicus 41-44 22846496-4 2013 Neonatal IH augments hypoxia-evoked carotid body sensory excitation and catecholamine secretion from AMC which are mediated by reactive oxygen species (ROS)-dependent recruitment of endothelin-1 and Ca(2+) signaling, respectively. Catecholamines 72-85 endothelin 1 Homo sapiens 182-194 23567899-3 2013 Here we demonstrate that depolarization-evoked catecholamine release was decreased in chromaffin cells infected with semliki forest viral vectors encoding Sx1A mutants, Sx1A(C271V), or Sx1A(C272V), or by direct oxidation of these Sx1A transmembrane (TM) cysteine residues. Catecholamines 47-60 syntaxin 1A Homo sapiens 155-159 23567899-3 2013 Here we demonstrate that depolarization-evoked catecholamine release was decreased in chromaffin cells infected with semliki forest viral vectors encoding Sx1A mutants, Sx1A(C271V), or Sx1A(C272V), or by direct oxidation of these Sx1A transmembrane (TM) cysteine residues. Catecholamines 47-60 syntaxin 1A Homo sapiens 169-173 23567899-3 2013 Here we demonstrate that depolarization-evoked catecholamine release was decreased in chromaffin cells infected with semliki forest viral vectors encoding Sx1A mutants, Sx1A(C271V), or Sx1A(C272V), or by direct oxidation of these Sx1A transmembrane (TM) cysteine residues. Catecholamines 47-60 syntaxin 1A Homo sapiens 169-173 23567899-3 2013 Here we demonstrate that depolarization-evoked catecholamine release was decreased in chromaffin cells infected with semliki forest viral vectors encoding Sx1A mutants, Sx1A(C271V), or Sx1A(C272V), or by direct oxidation of these Sx1A transmembrane (TM) cysteine residues. Catecholamines 47-60 syntaxin 1A Homo sapiens 169-173 23105094-1 2012 Catestatin (CST), a chromogranin A (CHGA)-derived peptide, is a potent inhibitor of catecholamine release from adrenal chromaffin cells and postganglionic sympathetic axons. Catecholamines 84-97 chromogranin A Rattus norvegicus 36-40 23319980-2 2012 Renalase, with possible monoamine oxidase activity, which breaks down catecholamines like SSAO, is also expressed in the endothelium as well as in the kidney. Catecholamines 70-84 renalase, FAD dependent amine oxidase Homo sapiens 0-8 22886838-1 2012 BACKGROUND: Vasopressin is frequently used to treat catecholamine-resistant vasodilatory shock. Catecholamines 52-65 arginine vasopressin Rattus norvegicus 12-23 22886838-2 2012 It enhances the vasoconstrictor effects of catecholamines at concentrations of vasopressin that have none or only minimal intrinsic pressor effects. Catecholamines 43-57 arginine vasopressin Rattus norvegicus 79-90 22886838-18 2012 The apparent divergent roles of these pathways in mediating NE- versus VP-augmented pressor responses could potentially lead to new targeted therapies in catecholamine-resistant shock. Catecholamines 154-167 arginine vasopressin Rattus norvegicus 71-73 21785110-9 2012 Administration of epinephrine to wild-type TAC mice significantly increased left ventricular end-diastolic pressure and LW/BW, while CB1 agonists reduced the LW/BW and the plasma levels of catecholamine and increased myocardial activity of AMP-activated protein kinase. Catecholamines 189-202 cannabinoid receptor 1 (brain) Mus musculus 133-136 23129699-2 2012 The chromogranin A-derived fragment catestatin inhibits catecholamine release by acting as an endogenous nicotinic cholinergic antagonist and can rescue hypertension in the setting of chromogranin A-targeted ablation. Catecholamines 56-69 chromogranin A Homo sapiens 4-18 22831701-0 2012 Intact catecholamine inputs to the forebrain are required for appropriate regulation of corticotrophin-releasing hormone and vasopressin gene expression by corticosterone in the rat paraventricular nucleus. Catecholamines 7-20 arginine vasopressin Rattus norvegicus 125-136 27152152-4 2012 Both catecholamine-induced nonesterified fatty acid mobilization and insulin-stimulated storage of meal fatty acids are impaired in many WAT depots of insulin-resistant individuals. Catecholamines 5-18 insulin Homo sapiens 151-158 22962322-16 2012 Intraoperative vasopressin infusion should not be used routinely, but only in catecholamine-refractory shock. Catecholamines 78-91 arginine vasopressin Homo sapiens 15-26 22815336-1 2012 Catechol-O-methyltransferase (COMT) catabolises the catecholamine neurotransmitters and influences cognitive function. Catecholamines 52-65 catechol-O-methyltransferase Rattus norvegicus 0-28 22815336-1 2012 Catechol-O-methyltransferase (COMT) catabolises the catecholamine neurotransmitters and influences cognitive function. Catecholamines 52-65 catechol-O-methyltransferase Rattus norvegicus 30-34 23008439-0 2012 Phosphoinositide 3-kinase gamma protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Catecholamines 49-62 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 0-31 22923736-5 2012 Our findings show that activation of neuronal H(3) and H(4) receptors inhibits the release of catecholamines elicited by BNP in cardiac synaptosomes and differentiated PC12 cells. Catecholamines 94-108 natriuretic peptide B Rattus norvegicus 121-124 22923736-8 2012 This indicates that PKG inhibition and PDE3 stimulation are pivotal for the H(3) and H(4) receptor-mediated attenuation of BNP-induced catecholamine release. Catecholamines 135-148 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 39-43 22923736-8 2012 This indicates that PKG inhibition and PDE3 stimulation are pivotal for the H(3) and H(4) receptor-mediated attenuation of BNP-induced catecholamine release. Catecholamines 135-148 natriuretic peptide B Rattus norvegicus 123-126 23162530-1 2012 UNLABELLED: alpha(2)-adrenoceptors (AR) lower central sympathetic output and peripheral catecholamine release, thereby protecting against sympathetic hyperactivity and hypertension. Catecholamines 88-101 adrenoceptor alpha 2A Rattus norvegicus 12-34 23121213-4 2012 Low-dose vasopressin increases systemic blood pressure and decreases the need for catecholamines in brain-dead organ donors but it is not available in many countries. Catecholamines 82-96 arginine vasopressin Homo sapiens 9-20 23136435-3 2012 Here, we show that substitution of two highly conserved tryptophan residues within the juxtamembrane domain (JMD) of the vesicular SNARE Synaptobrevin II (SybII) profoundly impairs priming of granules in mouse chromaffin cells without altering catecholamine release from single vesicles. Catecholamines 244-257 vesicle-associated membrane protein 2 Mus musculus 137-153 23136435-3 2012 Here, we show that substitution of two highly conserved tryptophan residues within the juxtamembrane domain (JMD) of the vesicular SNARE Synaptobrevin II (SybII) profoundly impairs priming of granules in mouse chromaffin cells without altering catecholamine release from single vesicles. Catecholamines 244-257 vesicle-associated membrane protein 2 Mus musculus 155-160 23107895-1 2012 Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes catecholamines and catecholamine-like substances via a superoxide (O2(-))-dependent mechanism using nicotinamide adenine dinucleotide (NADH) as a cofactor. Catecholamines 90-104 renalase, FAD dependent amine oxidase Homo sapiens 0-8 23107895-1 2012 Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes catecholamines and catecholamine-like substances via a superoxide (O2(-))-dependent mechanism using nicotinamide adenine dinucleotide (NADH) as a cofactor. Catecholamines 90-103 renalase, FAD dependent amine oxidase Homo sapiens 0-8 22911895-6 2012 These effects of stress on Ang II receptor expression may alter catecholamine biosynthesis, as tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in PC12 cells are decreased with Ang II treatment in the presence of ZD7155 (AT(1) receptor antagonist) or with CGP42112 (AT(2) receptor agonist) treatment. Catecholamines 64-77 angiogenin Rattus norvegicus 27-30 22911895-6 2012 These effects of stress on Ang II receptor expression may alter catecholamine biosynthesis, as tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in PC12 cells are decreased with Ang II treatment in the presence of ZD7155 (AT(1) receptor antagonist) or with CGP42112 (AT(2) receptor agonist) treatment. Catecholamines 64-77 angiogenin Rattus norvegicus 191-194 22911895-11 2012 Overall, the effects of stress on adrenomedullary AT(1A) and AT(2) receptor expression may contribute to allostatic changes, such as regulation of catecholamine biosynthesis. Catecholamines 147-160 angiotensin II receptor, type 1a Rattus norvegicus 50-55 22911895-11 2012 Overall, the effects of stress on adrenomedullary AT(1A) and AT(2) receptor expression may contribute to allostatic changes, such as regulation of catecholamine biosynthesis. Catecholamines 147-160 angiotensin II receptor, type 2 Mus musculus 61-75 22948532-4 2012 However, the enzyme monoamine oxidase-A (MAO-A), which has a key role in the degradation of catecholamines, has been associated with the pathophysiology and therapeutics of both MDD and CVD. Catecholamines 104-118 monoamine oxidase A Homo sapiens 20-39 22948532-4 2012 However, the enzyme monoamine oxidase-A (MAO-A), which has a key role in the degradation of catecholamines, has been associated with the pathophysiology and therapeutics of both MDD and CVD. Catecholamines 104-118 monoamine oxidase A Homo sapiens 41-46 22673596-1 2012 OBJECTIVE: alpha-Glycerophosphocholine (GPC) is a putative acetylcholine precursor that potentially increases growth hormone secretion through the action of acetylcholine-stimulated catecholamine. Catecholamines 182-195 growth hormone 1 Homo sapiens 110-124 23008439-2 2012 However, the role of PI3Kgamma in catecholamine-induced arrhythmia is currently unknown. Catecholamines 34-47 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 21-30 23021333-2 2012 BACKGROUND: The NPY is a potent pressor peptide co-released with catecholamines during stress by sympathetic axons. Catecholamines 65-79 neuropeptide Y Homo sapiens 16-19 22826131-11 2012 These extreme Cav1 channel modulations may occur either during high-frequency sympathetic stimulation to sustain prolonged catecholamine release (maximal L-type current) or following activation of the NO-cGMP-PKG signalling pathway (minimal L-type current) to limit the steady release of catecholamines. Catecholamines 123-136 caveolin 1, caveolae protein Mus musculus 14-18 22912364-7 2012 VEGFR-2 knockdown attenuated these effects, including inhibition of TH activity and catecholamine secretion, suggesting that they were mediated by VEGFR-2. Catecholamines 84-97 kinase insert domain receptor Rattus norvegicus 0-7 22700802-1 2012 A reduction in catecholamine levels during exercise has been described in young subjects with type 1 diabetes mellitus (DM1). Catecholamines 15-28 immunoglobulin heavy diversity 1-7 Homo sapiens 120-123 22826131-11 2012 These extreme Cav1 channel modulations may occur either during high-frequency sympathetic stimulation to sustain prolonged catecholamine release (maximal L-type current) or following activation of the NO-cGMP-PKG signalling pathway (minimal L-type current) to limit the steady release of catecholamines. Catecholamines 288-302 caveolin 1, caveolae protein Mus musculus 14-18 23040481-4 2012 Furthermore, we show that this effect on HSC generation is secondary to the role of Gata3 in the production of catecholamines, the mediators of the sympathetic nervous system (SNS), thus making these molecules key components of the AGM HSC niche. Catecholamines 111-125 GATA binding protein 3 Homo sapiens 84-89 23040481-4 2012 Furthermore, we show that this effect on HSC generation is secondary to the role of Gata3 in the production of catecholamines, the mediators of the sympathetic nervous system (SNS), thus making these molecules key components of the AGM HSC niche. Catecholamines 111-125 fucosyltransferase 1 (H blood group) Homo sapiens 236-239 22628174-1 2012 Autoantibodies against the second extracellular loop of beta(1) -adrenergic receptor (beta(1) -AA) not only contribute to increased susceptibility to heart failure, but also play a causative role in myocardial remodeling through their catecholamine-like effects via binding with the beta(1) -adrenergic receptor. Catecholamines 235-248 adrenoceptor beta 1 Homo sapiens 56-97 22152146-2 2012 The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 11-39 22152146-2 2012 The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 41-45 22152146-2 2012 The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 82-86 22865387-11 2012 The heart rate increment in response to catecholamines was also similar in P2Y(4) wild-type and P2Y(4)-null implanted mice, which is consistent with a similar level of cardiac beta-receptor expression. Catecholamines 40-54 pyrimidinergic receptor P2Y, G-protein coupled, 4 Mus musculus 75-81 22996798-2 2012 CE with LIF detection for the determination of FITC derivatized catecholamines (dopamine, epinephrine, and norepinephrine) was demonstrated. Catecholamines 64-78 LIF, interleukin 6 family cytokine Rattus norvegicus 8-11 22996798-6 2012 Furthermore, this microwave-assisted derivatization CE-LIF method successfully determined catecholamines in rat brain with as low as 100 ng L-1 (FASS mode) to 10 mug L-1 (normal injection mode). Catecholamines 90-104 LIF, interleukin 6 family cytokine Rattus norvegicus 55-58 22628174-1 2012 Autoantibodies against the second extracellular loop of beta(1) -adrenergic receptor (beta(1) -AA) not only contribute to increased susceptibility to heart failure, but also play a causative role in myocardial remodeling through their catecholamine-like effects via binding with the beta(1) -adrenergic receptor. Catecholamines 235-248 adrenoceptor beta 1 Homo sapiens 56-84 22610912-5 2012 PACAP is responsible for long-term catecholamine secretion using secretory mechanisms different from the rapidly desensitizing depolarization evoked by acetylcholine through nicotinic receptor activation. Catecholamines 35-48 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 22975104-15 2012 Elevated response to catecholamines after VAD support is influenced by beta1-AR upregulation and modulation of AC activity. Catecholamines 21-35 adrenoceptor beta 1 Homo sapiens 71-79 22415354-3 2012 By crossing these two knockout strains, we generated a viable and fertile double CgA/B-KO mouse in which the catecholamine content in chromaffin LDCVs was halved, and the secretory response significantly reduced. Catecholamines 109-122 chromogranin A Mus musculus 81-86 22610912-6 2012 PACAP signaling also maintains catecholamine synthesis required for sustained secretion during prolonged stress via induction of the enzymes TH and PNMT, and enhances transcription of additional secreted molecules found in chromaffin cells that alter further secretion through both autocrine and paracrine mechanisms. Catecholamines 31-44 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 22858378-4 2012 Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase. Catecholamines 22-36 fibronectin 1 Homo sapiens 100-111 22976420-7 2012 Activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal system (SAS) with the release of cortisol and catecholamines appear to be responsible for altering the Th1/Th2 balance. Catecholamines 126-140 negative elongation factor complex member C/D Homo sapiens 183-186 22858378-4 2012 Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase. Catecholamines 22-36 fibronectin 1 Homo sapiens 180-191 22791813-7 2012 Using the PDAC cell lines BxPC-3 and Panc-1 and immortalized pancreatic duct epithelial cell line HPDE6-C7, our current experiments reveal a significant sensitization of the nAChR-driven autocrine catecholamine regulatory loop in cells pre-exposed to nicotine for 7 days. Catecholamines 197-210 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 174-179 22925890-2 2012 Since tyrosine hydroxylase is the rate-limiting step in catecholamine synthesis, an effect of ascorbate to increase tyrosine hydroxylase protein could contribute to its ability to increase or sustain catecholamine synthesis. Catecholamines 56-69 tyrosine hydroxylase Homo sapiens 6-26 22925890-2 2012 Since tyrosine hydroxylase is the rate-limiting step in catecholamine synthesis, an effect of ascorbate to increase tyrosine hydroxylase protein could contribute to its ability to increase or sustain catecholamine synthesis. Catecholamines 200-213 tyrosine hydroxylase Homo sapiens 116-136 22791813-8 2012 The resulting increase in catecholamine production was associated with significant inductions in the phosphorylation of signaling proteins ERK, CREB, Src and AKT, upregulated protein expression of nAChR subunits alpha3, alpha4, alpha5 and alpha7 and increased responsiveness to nicotine in 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide and cell migration assays. Catecholamines 26-39 mitogen-activated protein kinase 1 Homo sapiens 139-142 22791813-8 2012 The resulting increase in catecholamine production was associated with significant inductions in the phosphorylation of signaling proteins ERK, CREB, Src and AKT, upregulated protein expression of nAChR subunits alpha3, alpha4, alpha5 and alpha7 and increased responsiveness to nicotine in 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide and cell migration assays. Catecholamines 26-39 cAMP responsive element binding protein 1 Homo sapiens 144-148 22791813-8 2012 The resulting increase in catecholamine production was associated with significant inductions in the phosphorylation of signaling proteins ERK, CREB, Src and AKT, upregulated protein expression of nAChR subunits alpha3, alpha4, alpha5 and alpha7 and increased responsiveness to nicotine in 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide and cell migration assays. Catecholamines 26-39 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 150-153 22791813-8 2012 The resulting increase in catecholamine production was associated with significant inductions in the phosphorylation of signaling proteins ERK, CREB, Src and AKT, upregulated protein expression of nAChR subunits alpha3, alpha4, alpha5 and alpha7 and increased responsiveness to nicotine in 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide and cell migration assays. Catecholamines 26-39 AKT serine/threonine kinase 1 Homo sapiens 158-161 22791813-8 2012 The resulting increase in catecholamine production was associated with significant inductions in the phosphorylation of signaling proteins ERK, CREB, Src and AKT, upregulated protein expression of nAChR subunits alpha3, alpha4, alpha5 and alpha7 and increased responsiveness to nicotine in 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide and cell migration assays. Catecholamines 26-39 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 197-202 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 0-26 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Catecholamines 38-51 dopamine beta-hydroxylase Rattus norvegicus 28-31 22337560-1 2012 BACKGROUND: The COMT enzyme metabolizes catecholamines and thus modulates adrenergic, noradrenergic and dopaminergic signaling. Catecholamines 40-54 catechol-O-methyltransferase Homo sapiens 16-20 22684282-1 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthetic pathway for catecholamine synthesis. Catecholamines 86-99 tyrosine hydroxylase Rattus norvegicus 0-20 22684282-1 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthetic pathway for catecholamine synthesis. Catecholamines 86-99 tyrosine hydroxylase Rattus norvegicus 22-24 22684282-2 2012 Stress triggers an increase in TH activity, resulting in increased release of catecholamines from both neurons and the adrenal medulla. Catecholamines 78-92 tyrosine hydroxylase Rattus norvegicus 31-33 22784685-1 2012 BACKGROUND: The Met158 allele of catechol-O-methyl transferase (COMT) gene is associated with increased levels of catecholamines in the prefrontal cortex and may increase the likelihood of aggressiveness. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 33-62 22784685-1 2012 BACKGROUND: The Met158 allele of catechol-O-methyl transferase (COMT) gene is associated with increased levels of catecholamines in the prefrontal cortex and may increase the likelihood of aggressiveness. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 64-68 22889256-13 2012 CONCLUSIONS: Vasopressin use in vasodilatory shock is safe, associated with reduced mortality, and facilitates weaning of catecholamines. Catecholamines 122-136 arginine vasopressin Homo sapiens 13-24 21958961-1 2012 Cytochrome P450 2D6 (CYP2D6) is a drug-metabolizing enzyme expressed in the brain that also metabolizes endogenous neural compounds (e.g., catecholamines) and inactivates neurotoxins (e.g., 1-methyl-4-thenyl-1,2,3,6-tetrahydropyridine; MPTP). Catecholamines 139-153 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 0-19 21958961-1 2012 Cytochrome P450 2D6 (CYP2D6) is a drug-metabolizing enzyme expressed in the brain that also metabolizes endogenous neural compounds (e.g., catecholamines) and inactivates neurotoxins (e.g., 1-methyl-4-thenyl-1,2,3,6-tetrahydropyridine; MPTP). Catecholamines 139-153 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 21-27 22732314-12 2012 We suggest this epinephrine-specific beta(2)AR-G(i) signaling may have evolved as a cardioprotective strategy to limit catecholamine-induced myocardial toxicity during acute stress. Catecholamines 119-132 adrenoceptor beta 2 Rattus norvegicus 37-46 22471594-0 2012 Effect of lipopolysaccharide, cytokines, and catecholamines on brain natriuretic peptide release from human myocardium. Catecholamines 45-59 natriuretic peptide B Homo sapiens 63-88 22592408-6 2012 PACAP stimulates catecholamine release through a PKC-dependent pathway that is mechanistically independent of cholinergic excitation. Catecholamines 17-30 adenylate cyclase activating polypeptide 1 Mus musculus 0-5 22519418-0 2012 Blockade of beta-adrenoceptors restores the GRK2-mediated adrenal alpha(2) -adrenoceptor-catecholamine production axis in heart failure. Catecholamines 89-102 G protein-coupled receptor kinase 2 Rattus norvegicus 44-48 22519418-4 2012 The GPCR kinase-2 (GRK2)-alpha(2) adrenoceptor-catecholamine production axis is up-regulated in the adrenal medulla during HF causing alpha(2) -adrenoceptor dysfunction and elevated catecholamine levels. Catecholamines 47-60 G protein-coupled receptor kinase 2 Rattus norvegicus 4-17 22519418-4 2012 The GPCR kinase-2 (GRK2)-alpha(2) adrenoceptor-catecholamine production axis is up-regulated in the adrenal medulla during HF causing alpha(2) -adrenoceptor dysfunction and elevated catecholamine levels. Catecholamines 47-60 G protein-coupled receptor kinase 2 Rattus norvegicus 19-23 22519418-4 2012 The GPCR kinase-2 (GRK2)-alpha(2) adrenoceptor-catecholamine production axis is up-regulated in the adrenal medulla during HF causing alpha(2) -adrenoceptor dysfunction and elevated catecholamine levels. Catecholamines 182-195 G protein-coupled receptor kinase 2 Rattus norvegicus 4-17 22519418-4 2012 The GPCR kinase-2 (GRK2)-alpha(2) adrenoceptor-catecholamine production axis is up-regulated in the adrenal medulla during HF causing alpha(2) -adrenoceptor dysfunction and elevated catecholamine levels. Catecholamines 182-195 G protein-coupled receptor kinase 2 Rattus norvegicus 19-23 22957414-5 2012 Increased MAO activity with correlated increase in genomic DNA degradation in the diabetic brain supports the hypothesis that catecholamine oxidation is an important source of oxidative stress, causing loss of membrane fluidity, increased neurolipofuscin and decreased of GLUT4 expression with diabetes in the brain. Catecholamines 126-139 monoamine oxidase A Rattus norvegicus 10-13 21896235-8 2012 BMP7 has unique developmental and trophic actions on catecholamine neurons and these findings suggest that reduced astrocyte support for pontine LC neurons may contribute to pathology of brain noradrenergic neurons in MDD. Catecholamines 53-66 bone morphogenetic protein 7 Rattus norvegicus 0-4 22569243-1 2012 CONTEXT: The high diagnostic performance of plasma-free metanephrines (metanephrine and normetanephrine) (MN) for pheochromocytoma (PHEO) results from the tumoral expression of catechol-O-methyltransferase (COMT), the enzyme involved in O-methylation of catecholamines (CAT). Catecholamines 254-268 catechol-O-methyltransferase Homo sapiens 177-205 22812913-1 2012 BACKGROUND: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 137-151 renalase, FAD dependent amine oxidase Homo sapiens 12-20 22812913-1 2012 BACKGROUND: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Catecholamines 137-151 renalase, FAD dependent amine oxidase Homo sapiens 32-36 23700531-4 2012 Fatty acid release by murine adipocytes following fasting or treatment with glucocorticoids or catecholamines is highly Angptl4-dependent. Catecholamines 95-109 angiopoietin-like 4 Mus musculus 120-127 22036874-4 2012 Eighteen catecholamine-related analytes were examined in relation to tumour location, size and mutations of succinate dehydrogenase subunit B (SDHB). Catecholamines 9-22 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 108-141 22957414-5 2012 Increased MAO activity with correlated increase in genomic DNA degradation in the diabetic brain supports the hypothesis that catecholamine oxidation is an important source of oxidative stress, causing loss of membrane fluidity, increased neurolipofuscin and decreased of GLUT4 expression with diabetes in the brain. Catecholamines 126-139 solute carrier family 2 member 4 Rattus norvegicus 272-277 22516009-5 2012 In contrast, Fos-IR in brainstem catecholamine neurons decreased after the administration of GLP-2. Catecholamines 33-46 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-16 22665130-3 2012 We demonstrated that genes coding for tyrosine hydroxylase, Dopa decarboxylase, dopamine beta hydroxylase (DbetaH), and phenylethanolamine-N-methyl transferase, enzymes involved in the synthesis of catecholamines, are all expressed in basal conditions in bovine aorta ECs, and their expression is enhanced in response to hypoxia. Catecholamines 198-212 tyrosine hydroxylase Bos taurus 38-58 22665130-3 2012 We demonstrated that genes coding for tyrosine hydroxylase, Dopa decarboxylase, dopamine beta hydroxylase (DbetaH), and phenylethanolamine-N-methyl transferase, enzymes involved in the synthesis of catecholamines, are all expressed in basal conditions in bovine aorta ECs, and their expression is enhanced in response to hypoxia. Catecholamines 198-212 dopa decarboxylase Mus musculus 60-78 22665130-3 2012 We demonstrated that genes coding for tyrosine hydroxylase, Dopa decarboxylase, dopamine beta hydroxylase (DbetaH), and phenylethanolamine-N-methyl transferase, enzymes involved in the synthesis of catecholamines, are all expressed in basal conditions in bovine aorta ECs, and their expression is enhanced in response to hypoxia. Catecholamines 198-212 dopamine beta-hydroxylase Bos taurus 80-105 22547424-10 2012 CONCLUSIONS: These results suggest that genetically altered fatty acid metabolism predisposes to type 2 diabetes and propose a role for catecholamine-metabolizing enzymes like MAOA in the regulation of energy metabolism. Catecholamines 136-149 monoamine oxidase A Homo sapiens 176-180 22568433-0 2012 The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Catecholamines 116-129 sex determining region Y Homo sapiens 36-39 22568433-10 2012 Combined, these results suggest that SRY plays a role as a positive regulator of catecholamine synthesis and metabolism in the human male midbrain. Catecholamines 81-94 sex determining region Y Homo sapiens 37-40 22535963-1 2012 Chromogranin A knock-out (Chga-KO) mice display increased adiposity despite high levels of circulating catecholamines and leptin. Catecholamines 103-117 chromogranin A Mus musculus 0-14 22535963-1 2012 Chromogranin A knock-out (Chga-KO) mice display increased adiposity despite high levels of circulating catecholamines and leptin. Catecholamines 103-117 chromogranin A Mus musculus 26-30 22496244-2 2012 There is evidence demonstrating that activation of these kinases and induction of PGC-1alpha in skeletal muscle are regulated by catecholamines. Catecholamines 129-143 PPARG coactivator 1 alpha Rattus norvegicus 82-92 22516009-5 2012 In contrast, Fos-IR in brainstem catecholamine neurons decreased after the administration of GLP-2. Catecholamines 33-46 mast cell protease 10 Rattus norvegicus 93-98 22483310-3 2012 Tyrosine hydroxylase (TH) is an important neuronal enzyme that, in the presence of tetrahydrobiopterin, catalyzes the initial and rate-limiting step in the biosynthesis of the catecholamine neurotransmitters dopamine (DA) and norepinephrine, and is frequently used as a marker of DAergic neuronal loss in animal models of PD. Catecholamines 176-189 tyrosine hydroxylase Homo sapiens 0-20 22450660-4 2012 In contrast to amino acid neurotransmitters, catecholamine neurotransmitters, L-DOPA, and curcumin prevent significant iron-mediated DNA damage (IC(50) values of 3.2 to 18 muM) and are electrochemically active. Catecholamines 45-58 latexin Homo sapiens 172-175 23165879-4 2012 Aim of this study was to use a simple and highly reproducible catecholamine cell model and transmission electron microscopy to characterize whether PINK1 could affect mitochondrial homeostasis, the recruitment of specific proteins at mitochondria, mitophagy and apoptosis. Catecholamines 62-75 PTEN induced kinase 1 Homo sapiens 148-153 22408002-0 2012 The male fight-flight response: a result of SRY regulation of catecholamines? Catecholamines 62-76 sex determining region Y Homo sapiens 44-47 22483314-1 2012 Tyrosine hydroxylase (TH) is the rate limiting step in the biosynthesis of dopamine and other catecholamines. Catecholamines 94-108 tyrosine hydroxylase Homo sapiens 0-20 22585553-8 2012 Here we present a patient with severe, progressive neonatal HCM, elevated urinary catecholamine metabolites, and dysmorphic features in whom we identified a known LEOPARD syndrome-associated PTPN11 mutation (c.1403 C > T; p.T468M) and a novel, potentially pathogenic missense SOS1 variant (c.1018 C > T; p.P340S) replacing a rigid nonpolar imino acid with a polar amino acid at a highly conserved position. Catecholamines 82-95 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 191-197 22583429-0 2012 Molecular docking study of catecholamines and [4-(propan-2-yl) phenyl]carbamic acid with tyrosine hydroxylase. Catecholamines 27-41 tyrosine hydroxylase Homo sapiens 89-109 22583429-2 2012 As the classical disease-related motor symptoms are associated with the loss of dopamine-generating cells within the substantia nigra, tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines has become an important target in the development of Parkinson"s disease drug candidates, with the focus to augment TH levels or its activity. Catecholamines 207-221 tyrosine hydroxylase Homo sapiens 135-155 22583429-2 2012 As the classical disease-related motor symptoms are associated with the loss of dopamine-generating cells within the substantia nigra, tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines has become an important target in the development of Parkinson"s disease drug candidates, with the focus to augment TH levels or its activity. Catecholamines 207-221 tyrosine hydroxylase Homo sapiens 157-159 22583429-3 2012 By contrast, TH inhibitors are of relevance in the treatment of conditions associated with catecholamine over-production, as occurs in pheochromocytomas. Catecholamines 91-104 tyrosine hydroxylase Homo sapiens 13-15 22483314-1 2012 Tyrosine hydroxylase (TH) is the rate limiting step in the biosynthesis of dopamine and other catecholamines. Catecholamines 94-108 tyrosine hydroxylase Homo sapiens 22-24 22483316-1 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in brain catecholamine biosynthesis, and tetrahydrobiopterin is its cofactor. Catecholamines 63-76 tyrosine hydroxylase Homo sapiens 0-20 22483316-1 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in brain catecholamine biosynthesis, and tetrahydrobiopterin is its cofactor. Catecholamines 63-76 tyrosine hydroxylase Homo sapiens 22-24 22583429-4 2012 To aid characterizing new drug candidates, a molecular docking study of catecholamines and a novel hypothetical compound [4-(propan-2-yl) phenyl]carbamic acid (PPCA) with TH is described. Catecholamines 72-86 cathepsin A Homo sapiens 160-164 22583429-4 2012 To aid characterizing new drug candidates, a molecular docking study of catecholamines and a novel hypothetical compound [4-(propan-2-yl) phenyl]carbamic acid (PPCA) with TH is described. Catecholamines 72-86 tyrosine hydroxylase Homo sapiens 171-173 22583429-7 2012 Our results corroborated a "hexa interacting amino acids unit" located in this deep narrow groove crucial to the interaction of PPCA and the studied catecholamines with TH, whereby the "His361-His336 dyad" was found to be even more crucial to these binding interactions. Catecholamines 149-163 cathepsin A Homo sapiens 128-132 22583429-7 2012 Our results corroborated a "hexa interacting amino acids unit" located in this deep narrow groove crucial to the interaction of PPCA and the studied catecholamines with TH, whereby the "His361-His336 dyad" was found to be even more crucial to these binding interactions. Catecholamines 149-163 tyrosine hydroxylase Homo sapiens 169-171 22483310-3 2012 Tyrosine hydroxylase (TH) is an important neuronal enzyme that, in the presence of tetrahydrobiopterin, catalyzes the initial and rate-limiting step in the biosynthesis of the catecholamine neurotransmitters dopamine (DA) and norepinephrine, and is frequently used as a marker of DAergic neuronal loss in animal models of PD. Catecholamines 176-189 tyrosine hydroxylase Homo sapiens 22-24 22361482-7 2012 Vasopressin has demonstrated utility in the management of catecholamine-resistant shock after tumor resection. Catecholamines 58-71 arginine vasopressin Homo sapiens 0-11 21702050-0 2012 The calcineurin-nuclear factor of activated T cells signaling pathway mediates the effect of corticotropin releasing factor and urocortins on catecholamine synthesis. Catecholamines 142-155 corticotropin releasing hormone Rattus norvegicus 93-123 21855282-13 2012 CONCLUSIONS: Effects of vasopressin on catecholamine dosing requirements in the setting of septic shock may be influenced by body weight. Catecholamines 39-52 arginine vasopressin Homo sapiens 24-35 22624839-3 2012 Unlike beta1- and beta2-ARs, beta3-ARs are stimulated at high catecholamine concentrations and induce negative inotropic effects, serving as a "brake" to protect the heart from catecholamine overstimulation. Catecholamines 62-75 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 29-34 22624839-3 2012 Unlike beta1- and beta2-ARs, beta3-ARs are stimulated at high catecholamine concentrations and induce negative inotropic effects, serving as a "brake" to protect the heart from catecholamine overstimulation. Catecholamines 177-190 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 29-34 22396018-6 2012 We conclude that catecholamine release is responsible for the ER stress response and impaired insulin receptor signaling after burn injury. Catecholamines 17-30 insulin receptor Homo sapiens 94-110 22483291-1 2012 One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system. Catecholamines 41-54 catechol-O-methyltransferase Homo sapiens 62-95 22483291-1 2012 One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system. Catecholamines 41-54 catechol-O-methyltransferase Homo sapiens 97-101 22466342-1 2012 CONTEXT: The beta(2)-adrenergic receptor (ADRB2) influences regulation of energy balance by stimulating catecholamine-induced lipolysis in adipose tissue. Catecholamines 104-117 adrenoceptor beta 2 Homo sapiens 42-47 22289055-7 2012 In the periphery, VIP and PACAP play important roles in the control of immunity and inflammation, the control of pancreatic insulin secretion, the release of catecholamines from the adrenal medulla and as co-transmitters in autonomic and sensory neurons. Catecholamines 158-172 vasoactive intestinal peptide Homo sapiens 18-21 22289055-7 2012 In the periphery, VIP and PACAP play important roles in the control of immunity and inflammation, the control of pancreatic insulin secretion, the release of catecholamines from the adrenal medulla and as co-transmitters in autonomic and sensory neurons. Catecholamines 158-172 adenylate cyclase activating polypeptide 1 Homo sapiens 26-31 22483294-2 2012 Catechol-O-mehyltransferase (COMT) is surfacing with a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 0-27 22483294-2 2012 Catechol-O-mehyltransferase (COMT) is surfacing with a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 29-33 22483298-3 2012 The present review summarises clinical, mutant, and psychopharmacological data related to catechol-O-methyltransferase (COMT), an enzyme involved in the catabolism of catecholamine neurotransmitters, with a view to establishing the antipsychotic potential of compounds targeting the action of this enzyme. Catecholamines 167-180 catechol-O-methyltransferase Homo sapiens 90-118 22483298-3 2012 The present review summarises clinical, mutant, and psychopharmacological data related to catechol-O-methyltransferase (COMT), an enzyme involved in the catabolism of catecholamine neurotransmitters, with a view to establishing the antipsychotic potential of compounds targeting the action of this enzyme. Catecholamines 167-180 catechol-O-methyltransferase Homo sapiens 120-124 21702050-2 2012 Aim of the current work was to examine if the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the effect of CRF peptides in catecholamine synthesis and secretion from PC12 rat pheochromocytona cells, a model for the study of adrenal catecholamine production. Catecholamines 164-177 nuclear factor of activated T-cells 5 Rattus norvegicus 58-62 21702050-2 2012 Aim of the current work was to examine if the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the effect of CRF peptides in catecholamine synthesis and secretion from PC12 rat pheochromocytona cells, a model for the study of adrenal catecholamine production. Catecholamines 273-286 nuclear factor of activated T-cells 5 Rattus norvegicus 58-62 21702050-11 2012 In conclusion, our data suggest that CRF(1) and CRF(2) ligands activate the transcription factor NFAT and its activation is prerequisite for CRF-induced catecholamine production from chromaffin cells. Catecholamines 153-166 corticotropin releasing hormone receptor 1 Rattus norvegicus 37-43 22357947-8 2012 Consistently, CST peptides blocked various stages of nAChR signal transduction, such as nicotine- or acetylcholine-evoked inward current, rise in intracellular Ca(2+) and catecholamine secretion in or from neuron-differentiated PC12 cells, in the same rank order. Catecholamines 171-184 cystatin 12, pseudogene Homo sapiens 14-17 21702050-11 2012 In conclusion, our data suggest that CRF(1) and CRF(2) ligands activate the transcription factor NFAT and its activation is prerequisite for CRF-induced catecholamine production from chromaffin cells. Catecholamines 153-166 corticotropin releasing hormone receptor 2 Rattus norvegicus 48-53 21702050-11 2012 In conclusion, our data suggest that CRF(1) and CRF(2) ligands activate the transcription factor NFAT and its activation is prerequisite for CRF-induced catecholamine production from chromaffin cells. Catecholamines 153-166 nuclear factor of activated T-cells 5 Rattus norvegicus 97-101 22411356-7 2012 Catecholamine injury in Galpha (i2) (G184S/G184S) mutant mice produced markedly increased isoproterenol-induced fibrosis and collagen III gene expression vs WT mice. Catecholamines 0-13 guanine nucleotide binding protein (G protein), alpha inhibiting 2 Mus musculus 24-34 22371619-7 2012 The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 39-67 21424526-1 2012 Renalase is an amine oxidase expressed in kidney, heart, liver, and brain that metabolizes catecholamines. Catecholamines 91-105 renalase, FAD-dependent amine oxidase Rattus norvegicus 0-8 21424526-3 2012 Its expression is modulated by salt intake, and urinary renalase may regulate catecholamines levels and effect renal sodium and phosphate transport. Catecholamines 78-92 renalase, FAD-dependent amine oxidase Rattus norvegicus 56-64 21926664-12 2012 CONCLUSION: Low-dose arginine vasopressin infusion initiated in the operating room after complex neonatal cardiac surgery was associated with decreased fluid resuscitation and catecholamine requirements in the first 24 postoperative hours. Catecholamines 176-189 arginine vasopressin Homo sapiens 30-41 22283829-0 2012 Overexpression of apolipoprotein B attenuates pathologic cardiac remodeling and hypertrophy in response to catecholamines and after myocardial infarction in mice. Catecholamines 107-121 apolipoprotein B Mus musculus 18-34 22293600-7 2012 We also show that activation of beta-adrenergic receptors on Mphi by catecholamine mediates the HS/R-induced release of high-mobility group box 1. Catecholamines 69-82 high mobility group box 1 Mus musculus 120-145 22093677-1 2012 In the present study, we explored the association of catecholamines with insulin sensitivity in "metabolically healthy but obese" (MHO) individuals, by examining the metabolic characteristics and plasma catecholamine levels in 100 obese, sedentary postmenopausal women. Catecholamines 53-67 insulin Homo sapiens 73-80 22093677-1 2012 In the present study, we explored the association of catecholamines with insulin sensitivity in "metabolically healthy but obese" (MHO) individuals, by examining the metabolic characteristics and plasma catecholamine levels in 100 obese, sedentary postmenopausal women. Catecholamines 53-66 insulin Homo sapiens 73-80 22659670-4 2012 Renalase, as a new biomarker of heart and kidney functional correlation, can lower blood pressure, protect ischemic heart muscle, improve heart function and degrade catecholamine. Catecholamines 165-178 renalase, FAD dependent amine oxidase Homo sapiens 0-8 22371619-7 2012 The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin. Catecholamines 198-212 catechol-O-methyltransferase Homo sapiens 69-73 22371524-5 2012 In 12-week-old animals, WT myocardium exhibited a significantly positive FFR, while that of MLP null mice was significantly negative, and the inotropic response to catecholamines was significantly reduced in MLP null mice. Catecholamines 164-178 cysteine and glycine-rich protein 3 Mus musculus 208-211 22326747-2 2012 As the only route in the catecholamine biosynthetic pathway, Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine. Catecholamines 25-38 phenylethanolamine N-methyltransferase Homo sapiens 61-99 22326747-2 2012 As the only route in the catecholamine biosynthetic pathway, Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine. Catecholamines 25-38 phenylethanolamine N-methyltransferase Homo sapiens 101-105 22508204-8 2012 We conclude that Infusion of low-dose vasopressin for patients with mild to moderate left ventricular systolic dysfunction during separation from CPB is beneficial for the postoperative hemodynamic profile, reduces the catecholamine doses required and improves left ventricular systolic function. Catecholamines 219-232 arginine vasopressin Homo sapiens 38-49 21922300-1 2012 OBJECTIVE: To assess the efficacy of arginine vasopressin (AVP) as a rescue therapy in children with catecholamine refractory vasodilatory shock and its effect on various hemodynamic, clinical, and laboratory variables. Catecholamines 101-114 arginine vasopressin Homo sapiens 46-57 21922300-11 2012 CONCLUSIONS: Concurrent addition of vasopressin at an appropriate stage help improving MAP significantly with decreased dependence on high dose catecholamines without any significant adverse effects. Catecholamines 144-158 arginine vasopressin Homo sapiens 36-47 21935944-7 2012 After spinal cord injections of a catecholamine neuron-selective toxin, there was a depletion of C1 neurons in the RTN area; thus it was determined that the mCherry-positive terminals located in the pre-Botzinger complex originated almost exclusively from the RTN-Phox2b (non-C1) neurons. Catecholamines 34-47 paired like homeobox 2B Homo sapiens 264-270 22310664-5 2012 We demonstrated that defective PPARgamma impairs catecholamine-induced lipolysis. Catecholamines 49-62 peroxisome proliferator activated receptor gamma Homo sapiens 31-40 21543215-6 2012 Gene expression of both basal and catecholamine-stimulated lipolytic enzymes, adipose triglyceride lipase and hormone-sensitive lipase was inhibited in HC mice adipose tissue. Catecholamines 34-47 patatin-like phospholipase domain containing 2 Mus musculus 78-105 21543215-6 2012 Gene expression of both basal and catecholamine-stimulated lipolytic enzymes, adipose triglyceride lipase and hormone-sensitive lipase was inhibited in HC mice adipose tissue. Catecholamines 34-47 lipase, hormone sensitive Mus musculus 110-134 22212880-2 2012 Here we tested the hypothesis that stress hormones, glucocorticoids, may affect noradrenergic system activity by modulating gene expression and function of tyrosine hydroxylase (TH), the key enzyme for catecholamine synthesis, in the rat brain during perinatal life. Catecholamines 202-215 tyrosine hydroxylase Rattus norvegicus 156-176 22212880-2 2012 Here we tested the hypothesis that stress hormones, glucocorticoids, may affect noradrenergic system activity by modulating gene expression and function of tyrosine hydroxylase (TH), the key enzyme for catecholamine synthesis, in the rat brain during perinatal life. Catecholamines 202-215 tyrosine hydroxylase Rattus norvegicus 178-180 22311731-2 2012 Cardiac FKBP12.6 overexpression protects against myocardial infarction-induced HF and catecholamine-promoted ventricular arrhythmias. Catecholamines 86-99 FK506 binding protein 1b Mus musculus 8-16 22192380-1 2012 Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Catecholamines 69-82 catechol-O-methyltransferase Mus musculus 0-28 22267746-8 2012 In support of this, cAMP levels and TG hydrolysis were reduced in primary Angptl4(-/-) murine adipocytes treated with catecholamines, which stimulate cAMP-dependent signaling to promote lipolysis, and was restored by treatment with purified human ANGPTL4. Catecholamines 118-132 angiopoietin-like 4 Mus musculus 74-81 22267746-8 2012 In support of this, cAMP levels and TG hydrolysis were reduced in primary Angptl4(-/-) murine adipocytes treated with catecholamines, which stimulate cAMP-dependent signaling to promote lipolysis, and was restored by treatment with purified human ANGPTL4. Catecholamines 118-132 angiopoietin like 4 Homo sapiens 247-254 22293370-1 2012 We previously reported that both nitric oxide (NO) generated from NO synthase by bombesin and NO generated from SIN-1 (NO donor) activate the brain cyclooxygenase (COX) (COX-1 for bombesin), thereby eliciting the secretion of both catecholamines (CA) from the adrenal medulla by brain thromboxane A(2)-mediated mechanisms in rats. Catecholamines 231-245 MAPK associated protein 1 Homo sapiens 112-117 22293370-1 2012 We previously reported that both nitric oxide (NO) generated from NO synthase by bombesin and NO generated from SIN-1 (NO donor) activate the brain cyclooxygenase (COX) (COX-1 for bombesin), thereby eliciting the secretion of both catecholamines (CA) from the adrenal medulla by brain thromboxane A(2)-mediated mechanisms in rats. Catecholamines 231-245 mitochondrially encoded cytochrome c oxidase I Homo sapiens 170-175 22311731-10 2012 Cardiac FKBP12.6 overexpression in the mouse blunts pressure overload-induced maladaptive LV remodelling and protects against catecholamine-promoted burst pacing-induced ventricular tachycardia by decreasing cardiac sensitivity to adrenergic stress and RyR2 S2814 phosphorylation, and decreasing NCX1 activity. Catecholamines 126-139 FK506 binding protein 1b Mus musculus 8-16 22311731-10 2012 Cardiac FKBP12.6 overexpression in the mouse blunts pressure overload-induced maladaptive LV remodelling and protects against catecholamine-promoted burst pacing-induced ventricular tachycardia by decreasing cardiac sensitivity to adrenergic stress and RyR2 S2814 phosphorylation, and decreasing NCX1 activity. Catecholamines 126-139 solute carrier family 8 (sodium/calcium exchanger), member 1 Mus musculus 296-300 22311731-10 2012 Cardiac FKBP12.6 overexpression in the mouse blunts pressure overload-induced maladaptive LV remodelling and protects against catecholamine-promoted burst pacing-induced ventricular tachycardia by decreasing cardiac sensitivity to adrenergic stress and RyR2 S2814 phosphorylation, and decreasing NCX1 activity. Catecholamines 126-139 ryanodine receptor 2, cardiac Mus musculus 253-257 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 tyrosine hydroxylase Rattus norvegicus 125-145 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 tyrosine hydroxylase Rattus norvegicus 147-149 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 dopamine beta-hydroxylase Rattus norvegicus 152-177 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 dopamine beta-hydroxylase Rattus norvegicus 179-182 21681478-3 2012 This study aimed at investigating physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase in the adrenal medulla and stellate ganglia of chronically psychosocially stressed adult rats exposed daily to 20-min treadmill exercise for 12 weeks, using TaqMan RT-PCR assay. Catecholamines 90-103 phenylethanolamine-N-methyltransferase Rattus norvegicus 188-226 22227817-4 2012 It was reported that renalase, secreted by the kidney and circulating in the blood, degraded catecholamines and might play a role in the regulation of sympathetic tone and BP. Catecholamines 93-107 renalase, FAD dependent amine oxidase Homo sapiens 21-29 22050625-5 2012 To investigate catecholamine-induced arrhythmias in the CASQ2 mutated cells, we generated for the first time CPVT-derived induced pluripotent stem cells (iPSCs) by reprogramming fibroblasts from skin biopsies of two patients, and demonstrated that the iPSCs carry the CASQ2 mutation. Catecholamines 15-28 calsequestrin 2 Homo sapiens 56-61 22223652-8 2012 Additional experiments demonstrated decreased 24-h urine catecholamines in male Ephb6 KO mice, probably as a compensatory feedback mechanism to keep their BP in the normal range. Catecholamines 57-71 Eph receptor B6 Mus musculus 80-85 22109853-5 2012 We also demonstrated that tyrosine hydroxylase (TH), the rate-limiting enzyme for synthesis of catecholamine, was reduced after exposure to IL-6, which was accompanied by JAK-STAT3 pathway activation. Catecholamines 95-108 interleukin 6 Homo sapiens 140-144 22109853-5 2012 We also demonstrated that tyrosine hydroxylase (TH), the rate-limiting enzyme for synthesis of catecholamine, was reduced after exposure to IL-6, which was accompanied by JAK-STAT3 pathway activation. Catecholamines 95-108 signal transducer and activator of transcription 3 Homo sapiens 175-180 22301784-3 2012 We demonstrate that costimulation of chromaffin cells by AVP and CRH simultaneously induces a catecholamine secretion exceeding the one induced by each hormone alone, thus demonstrating a net potentiation. Catecholamines 94-107 corticotropin releasing hormone Homo sapiens 65-68 22261351-7 2012 We observed that the beta-adrenoceptor agonist (isoproterenol) and beta(2)-adrenoceptor agonist (salbutamol) stimulated catecholamine (NE and EP) release from human adrenal chromaffin cells. Catecholamines 120-133 adrenoceptor beta 2 Homo sapiens 67-87 22261351-8 2012 Furthermore, the beta(2)-adrenoceptor antagonist (ICI 118,551; 100 nM) and beta(3)-adrenoceptor antagonist (SR 59230A; 100 nM) inhibited the catecholamine release stimulated by isoproterenol and nicotine in chromaffin cells. Catecholamines 141-154 adrenoceptor beta 2 Homo sapiens 17-37 22261351-8 2012 Furthermore, the beta(2)-adrenoceptor antagonist (ICI 118,551; 100 nM) and beta(3)-adrenoceptor antagonist (SR 59230A; 100 nM) inhibited the catecholamine release stimulated by isoproterenol and nicotine in chromaffin cells. Catecholamines 141-154 adrenoceptor beta 3 Homo sapiens 75-95 22223652-10 2012 It suggests that Ephb6 has a target in the nervous/endocrine system in addition to VSMC, regulating a testosterone-dependent catecholamine compensatory mechanism. Catecholamines 125-138 Eph receptor B6 Mus musculus 17-22 22129620-3 2012 Studies in the periphery and in vitro studies show that catestatin blocks nicotine-stimulated catecholamine release and interacts with beta-adrenoceptors and histamine receptors. Catecholamines 94-107 chromogranin A Homo sapiens 56-66 22474806-5 2012 Following the case study is a discussion of the impact that angiotensin II inhibitors may have on a patient undergoing general anesthesia and the role of vasopressin in reversing catecholamine-resistant hypotension. Catecholamines 179-192 arginine vasopressin Homo sapiens 154-165 22147898-11 2012 Thus, blocking RBC ERK1/2 activation, such as that promoted by catecholamine stress hormones, could ameliorate SCD pathophysiology. Catecholamines 63-76 mitogen-activated protein kinase 3 Homo sapiens 19-25 23080186-3 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine synthesis. Catecholamines 58-71 tyrosine hydroxylase Homo sapiens 0-20 22240810-5 2012 Primary hepatocytes isolated from CaMKK2 KO mice produce less glucose and have decreased mRNA encoding peroxisome proliferator-activated receptor gamma coactivator 1-alpha and the gluconeogenic enzymes glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, and these mRNA fail to respond specifically to the stimulatory effect of catecholamine in a cell-autonomous manner. Catecholamines 336-349 calcium/calmodulin-dependent protein kinase kinase 2, beta Mus musculus 34-40 22240810-9 2012 Collectively, these results are consistent with suppressed catecholamine-induced induction of gluconeogenic gene expression in CaMKK2 KO mice that leads to improved whole-body glucose homeostasis despite the presence of increased hepatic fat content. Catecholamines 59-72 calcium/calmodulin-dependent protein kinase kinase 2, beta Mus musculus 127-133 21818153-10 2012 Collectively these findings demonstrate, for the first time, that acute elevations in catecholamines induce PDK4 in adipose tissue from HFD rats, that this effect is likely independent of p38, a reputed mediator of PDK4 expression and that exercise, similar to TZDs can induce PDK4 in adipose tissue from obese, insulin resistant rats. Catecholamines 86-100 pyruvate dehydrogenase kinase 4 Rattus norvegicus 108-112 21818153-10 2012 Collectively these findings demonstrate, for the first time, that acute elevations in catecholamines induce PDK4 in adipose tissue from HFD rats, that this effect is likely independent of p38, a reputed mediator of PDK4 expression and that exercise, similar to TZDs can induce PDK4 in adipose tissue from obese, insulin resistant rats. Catecholamines 86-100 pyruvate dehydrogenase kinase 4 Rattus norvegicus 215-219 21818153-10 2012 Collectively these findings demonstrate, for the first time, that acute elevations in catecholamines induce PDK4 in adipose tissue from HFD rats, that this effect is likely independent of p38, a reputed mediator of PDK4 expression and that exercise, similar to TZDs can induce PDK4 in adipose tissue from obese, insulin resistant rats. Catecholamines 86-100 pyruvate dehydrogenase kinase 4 Rattus norvegicus 215-219 22219298-0 2012 Impairment of catecholamine systems during induction of long-term potentiation at hippocampal CA1 synapses in HPC-1/syntaxin 1A knock-out mice. Catecholamines 14-27 carbonic anhydrase 1 Mus musculus 94-97 22219298-0 2012 Impairment of catecholamine systems during induction of long-term potentiation at hippocampal CA1 synapses in HPC-1/syntaxin 1A knock-out mice. Catecholamines 14-27 syntaxin 1A (brain) Mus musculus 110-115 22219298-0 2012 Impairment of catecholamine systems during induction of long-term potentiation at hippocampal CA1 synapses in HPC-1/syntaxin 1A knock-out mice. Catecholamines 14-27 syntaxin 1A (brain) Mus musculus 116-127 22219298-5 2012 In addition, catecholamine release from the hippocampus was significantly reduced in STX1A(-/-) mice. Catecholamines 13-26 syntaxin 1A (brain) Mus musculus 85-90 23080170-7 2012 5-HT and the 5-HT2A antagonist ketanserin dose-dependently activated chemoreceptor cells as assessed by their capacity to release catecholamines from freshly isolated CB. Catecholamines 130-144 5-hydroxytryptamine receptor 2A Rattus norvegicus 13-19 22138106-12 2012 CONCLUSIONS: The cholinesterase inhibitor distigmine inhibited induction of inflammatory cytokines and catecholamines as well as HRV suppression in a rat CLP model, suggesting that an agent modulating the cholinergic anti-inflammatory pathway can control excess cytokine production involved in the pathogenesis of severe sepsis/septic shock. Catecholamines 103-117 butyrylcholinesterase Rattus norvegicus 17-31 22111578-1 2012 The Ca(2+) -dependent activator protein for secretion (CAPS) family consists of two members (CAPS1 and CAPS2) and regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals. Catecholamines 142-155 Ca2+-dependent secretion activator Mus musculus 4-53 22111578-1 2012 The Ca(2+) -dependent activator protein for secretion (CAPS) family consists of two members (CAPS1 and CAPS2) and regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals. Catecholamines 142-155 Ca2+-dependent secretion activator Mus musculus 55-59 22111578-1 2012 The Ca(2+) -dependent activator protein for secretion (CAPS) family consists of two members (CAPS1 and CAPS2) and regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals. Catecholamines 142-155 Ca2+-dependent secretion activator Mus musculus 93-98 22111578-1 2012 The Ca(2+) -dependent activator protein for secretion (CAPS) family consists of two members (CAPS1 and CAPS2) and regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals. Catecholamines 142-155 calcyphosphine 2 Mus musculus 103-108 22170706-7 2012 RESULTS: There was a significant inverse correlation between plasma beta-endorphin levels during exercise and catecholamine release during subsequent hypoglycemia. Catecholamines 110-123 proopiomelanocortin Homo sapiens 68-82 23080186-3 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine synthesis. Catecholamines 58-71 tyrosine hydroxylase Homo sapiens 22-24 23080186-4 2012 Several studies have examined the effects of hypoxia on catecholamines by focusing on the regulation of TH. Catecholamines 56-70 tyrosine hydroxylase Homo sapiens 104-106 21918574-2 2012 Chromogranin A (CHGA) is required for formation of the catecholamine secretory pathway in sympathochromaffin cells. Catecholamines 55-68 chromogranin A Homo sapiens 0-14 21918574-2 2012 Chromogranin A (CHGA) is required for formation of the catecholamine secretory pathway in sympathochromaffin cells. Catecholamines 55-68 chromogranin A Homo sapiens 16-20 22222551-2 2012 The purpose of this study is to determine whether early central catecholamine levels measured from cerebrospinal fluid (CSF) relate to outcome in patients with SAH. Catecholamines 64-77 colony stimulating factor 2 Homo sapiens 120-123 22572406-4 2012 ZENK-ir induction was quantified in catecholamine cells as well as within cells of unknown phenotypes in three brain regions that synthesize catecholamines, the ventral tegmental area, the periaqueductal gray and the locus coeruleus (LoC). Catecholamines 36-49 early growth response protein 1 Taeniopygia guttata 0-4 22572406-4 2012 ZENK-ir induction was quantified in catecholamine cells as well as within cells of unknown phenotypes in three brain regions that synthesize catecholamines, the ventral tegmental area, the periaqueductal gray and the locus coeruleus (LoC). Catecholamines 141-155 early growth response protein 1 Taeniopygia guttata 0-4 22572406-6 2012 However, when we limited our measurements to catecholamine-containing cells, we noticed a greater number of catecholamine-containing cells expressing ZENK within the LoC in the song-exposed females compared to silence-exposed females. Catecholamines 45-58 early growth response protein 1 Taeniopygia guttata 150-154 22572406-6 2012 However, when we limited our measurements to catecholamine-containing cells, we noticed a greater number of catecholamine-containing cells expressing ZENK within the LoC in the song-exposed females compared to silence-exposed females. Catecholamines 108-121 early growth response protein 1 Taeniopygia guttata 150-154 22222551-12 2012 CONCLUSIONS: CSF catecholamine levels are elevated in SAH patients who experience early mortality or disability. Catecholamines 17-30 colony stimulating factor 2 Homo sapiens 13-16 22834798-4 2012 As such CgA and its derived peptides may be regarded as mediators of a complex feedback system able to modulate the exaggerated release of catecholamines. Catecholamines 139-153 chromogranin A Homo sapiens 8-11 22471835-3 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 77-91 tyrosine hydroxylase Rattus norvegicus 0-20 22471835-3 2012 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 77-91 tyrosine hydroxylase Rattus norvegicus 22-24 22834795-1 2012 Chromogranin A (CgA), a major component of the chromaffin granules, is co-stored and co-released with catecholamines. Catecholamines 102-116 chromogranin A Homo sapiens 0-14 22834795-1 2012 Chromogranin A (CgA), a major component of the chromaffin granules, is co-stored and co-released with catecholamines. Catecholamines 102-116 chromogranin A Homo sapiens 16-19 22762470-7 2012 Regarding catecholamine-resistant vasodilatory shock, current evidence suggests that with adequate volume resuscitation, exogenous vasopressin in low "physiologic" doses (0.01-0.04 units/min) safely supports mean arterial pressure without adversely affecting myocardial function and splanchnic circulation. Catecholamines 10-23 arginine vasopressin Homo sapiens 131-142 22762470-9 2012 Although there is yet no clear cut mortality benefit, vasopressin is now recommended as a second-line agent in septic shock for its catecholamine-sparing effect and as an alternative to epinephrine in cardiopulmonary resuscitation. Catecholamines 132-145 arginine vasopressin Homo sapiens 54-65 22790479-2 2012 The catechol-O-methyltransferase (COMT) gene encodes an enzyme that degrades catecholamines and estrogens to less active metabolites. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 4-32 22790479-2 2012 The catechol-O-methyltransferase (COMT) gene encodes an enzyme that degrades catecholamines and estrogens to less active metabolites. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 34-38 21968540-5 2012 In in-vitro experiments, catecholamines inhibited poly I:C-induced TNF-alpha, but not IFN-beta, production in macrophages. Catecholamines 25-39 tumor necrosis factor Mus musculus 67-76 22539018-1 2012 UNLABELLED: Renalase, secreted by the kidney, degrades catecholamines and may play a role in the regulation of sympathetic tone and blood pressure. Catecholamines 55-69 renalase, FAD dependent amine oxidase Homo sapiens 12-20 23154672-4 2012 On the other hand, renalase, with possible monoamine oxidase activity, which breaks down catecholamines like SSAO, is also expressed in the endothelium as well as in the kidney. Catecholamines 89-103 renalase, FAD dependent amine oxidase Homo sapiens 19-27 22127290-11 2012 Our results show that activation of alpha7 and/or alpha4-containing nAChR subtypes have the ability to regulate catecholamine release from intact CB due to activation of fast inward currents expressed in chemoreceptor cells. Catecholamines 112-125 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 68-73 22913142-1 2012 The distribution of tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, was studied immunocytochemically in the neurons of substantia nigra in the human brain (n=7), and localization of neuromelanin in these cells was determined. Catecholamines 63-76 tyrosine hydroxylase Homo sapiens 20-40 22913142-1 2012 The distribution of tyrosine hydroxylase (TH), a key enzyme of catecholamine synthesis, was studied immunocytochemically in the neurons of substantia nigra in the human brain (n=7), and localization of neuromelanin in these cells was determined. Catecholamines 63-76 tyrosine hydroxylase Homo sapiens 42-44 22042385-6 2012 Indeed, global removal of 11beta-HSD2, an enzyme that inactivates glucocorticoids, increases anxiety- and depressive-like behaviour in mice; however, in this case the phenotype is not accompanied by overt perturbation in the HPA axis but, intriguingly, alterations in serotonergic and catecholamine pathways are maintained in this programming model. Catecholamines 285-298 hydroxysteroid 11-beta dehydrogenase 2 Mus musculus 26-37 22127290-12 2012 Therefore, our results suggest that both nAChR subtypes contribute to the cholinergic nicotinic regulation of catecholamine signaling in the carotid body system. Catecholamines 110-123 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 41-46 23160220-1 2012 OBJECTIVES: We explored effect of gene silencing of tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of catecholamines (CAs), in CD4+ T cells on differentiation and function of helper T (Th) cells to provide more evidence for functional significance of lymphocyte-derived CAs. Catecholamines 119-133 tyrosine hydroxylase Mus musculus 52-72 23160220-1 2012 OBJECTIVES: We explored effect of gene silencing of tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of catecholamines (CAs), in CD4+ T cells on differentiation and function of helper T (Th) cells to provide more evidence for functional significance of lymphocyte-derived CAs. Catecholamines 119-133 tyrosine hydroxylase Mus musculus 74-76 23160220-1 2012 OBJECTIVES: We explored effect of gene silencing of tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of catecholamines (CAs), in CD4+ T cells on differentiation and function of helper T (Th) cells to provide more evidence for functional significance of lymphocyte-derived CAs. Catecholamines 135-138 tyrosine hydroxylase Mus musculus 52-72 23160220-1 2012 OBJECTIVES: We explored effect of gene silencing of tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of catecholamines (CAs), in CD4+ T cells on differentiation and function of helper T (Th) cells to provide more evidence for functional significance of lymphocyte-derived CAs. Catecholamines 135-138 tyrosine hydroxylase Mus musculus 74-76 23160220-6 2012 RESULTS: CD4+ T lymphocytes with TH RNAi expressed less TH mRNA and protein and synthesized less CAs including norepinephrine, epinephrine and dopamine than control cells with mock transfection. Catecholamines 97-100 tyrosine hydroxylase Mus musculus 33-35 23056231-1 2012 A highly crystallizable T4 lysozyme (T4L) was fused to the N-terminus of the beta(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. Catecholamines 158-172 adrenoceptor beta 2 Homo sapiens 77-104 23209770-9 2012 Thus, changes in phosphorylation of serine residues in TH provide a highly sensitive measure of activity, cellular signaling and catecholamine utilization in catecholaminergic brain regions, in the short term, in response to hypotension and glucoprivation. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 55-57 22094268-14 2012 beta2AR but not GR was significantly increased after an acute stressor, which supports the hypothesis that catecholamine-mediated signal pathways in communication with the central nervous and immune systems play a fundamental role in acute stress-mediated immune alterations. Catecholamines 107-120 adrenoceptor beta 2 Homo sapiens 0-7 23049863-10 2012 Specifically, seipin was detected in oxytocin neurons of the paraventricular nucleus of the hypothalamus and in catecholamine neurons of the dorsal vagal complex. Catecholamines 112-125 Berardinelli-Seip congenital lipodystrophy 2 (seipin) Mus musculus 14-20 23056231-1 2012 A highly crystallizable T4 lysozyme (T4L) was fused to the N-terminus of the beta(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. Catecholamines 158-172 adrenoceptor beta 2 Homo sapiens 106-115 23056605-1 2012 Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 0-28 23056605-1 2012 Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 30-34 21790467-1 2012 Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Catecholamines 62-76 brain derived neurotrophic factor Homo sapiens 111-144 21790467-1 2012 Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Catecholamines 62-76 brain derived neurotrophic factor Homo sapiens 146-150 21790467-1 2012 Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 156-185 21790467-1 2012 Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 187-191 21790467-9 2012 This is the first evidence that meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms. Catecholamines 80-94 brain derived neurotrophic factor Homo sapiens 108-112 23017712-6 2012 Several hormones, including testosterone, estrogen, prolactin, glucocorticoids, catecholamines, and growth hormone, have been shown to inhibit adiponectin production, but the studies are still controversial. Catecholamines 80-94 adiponectin, C1Q and collagen domain containing Homo sapiens 143-154 22085992-10 2012 The nicotinic-acetylcholine receptor (nAChR) blocker hexamethonium induced a significant inhibition of the [(3)H]dopamine release produced by CC in PC12 cells but the TZ-elicited release of [(3)H]dopamine was 70% hexamethonium-insensitive, suggesting unidentified TZ toxins affecting other regulatory mechanisms of catecholamine secretion. Catecholamines 315-328 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 4-36 22085992-10 2012 The nicotinic-acetylcholine receptor (nAChR) blocker hexamethonium induced a significant inhibition of the [(3)H]dopamine release produced by CC in PC12 cells but the TZ-elicited release of [(3)H]dopamine was 70% hexamethonium-insensitive, suggesting unidentified TZ toxins affecting other regulatory mechanisms of catecholamine secretion. Catecholamines 315-328 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 38-43 21671973-2 2011 Recently, chromogranin A (CgA), a soluble protein costored and coreleased with catecholamines from the adrenal medulla and sympathetic nerve endings, has been proposed as a marker of sympathoadrenal medullary system (SAM) activity. Catecholamines 79-93 chromogranin A Homo sapiens 10-24 22009744-7 2011 PACAP stimulation did not evoke action potential firing in chromaffin cells but did cause a persistent subthreshold membrane depolarization that resulted in an immediate and robust Ca(2+)-dependent catecholamine secretion. Catecholamines 198-211 adenylate cyclase activating polypeptide 1 Mus musculus 0-5 22171049-5 2011 Results show that a hindbrain-originating catecholamine afferent system selectively engages a MAP kinase pathway in rat paraventricular hypothalamic CRH (corticotropin-releasing hormone) neuroendocrine neurons shortly after vascular insulin and 2-deoxyglucose challenges. Catecholamines 42-55 corticotropin releasing hormone Rattus norvegicus 149-152 22171049-5 2011 Results show that a hindbrain-originating catecholamine afferent system selectively engages a MAP kinase pathway in rat paraventricular hypothalamic CRH (corticotropin-releasing hormone) neuroendocrine neurons shortly after vascular insulin and 2-deoxyglucose challenges. Catecholamines 42-55 corticotropin releasing hormone Rattus norvegicus 154-185 21671973-2 2011 Recently, chromogranin A (CgA), a soluble protein costored and coreleased with catecholamines from the adrenal medulla and sympathetic nerve endings, has been proposed as a marker of sympathoadrenal medullary system (SAM) activity. Catecholamines 79-93 chromogranin A Homo sapiens 26-29 22013013-13 2011 CONCLUSIONS: Local catecholamine release into the VMH enhances counterregulatory responses to hypoglycemia via stimulation of B2AR. Catecholamines 19-32 adrenoceptor beta 2 Homo sapiens 126-130 21839840-8 2011 These results indicated collectively that CfPAH, as a homologue of phenylalanine hydroxylase in scallop C. farreri, could be induced by cytokine and involved in the immunomodulation of scallops by supplying the starting material tyrosine for the synthesis of melanin and catecholamines. Catecholamines 271-285 phenylalanine hydroxylase Homo sapiens 67-92 22172866-1 2011 INTRODUCTION: Renalase, an enzyme that breaks down catecholamines like adrenaline and noradrenaline in the blood circulation, was discovered in 2005. Catecholamines 51-65 renalase, FAD dependent amine oxidase Homo sapiens 14-22 21985068-2 2011 We recently demonstrated that loss-of-function mutations in the Drosophila gene Catecholamines up (Catsup) elevate dopamine pools but, paradoxically, also confer resistance to paraquat, an herbicide that induces oxidative stress-mediated toxicity in dopaminergic neurons. Catecholamines 80-94 Catecholamines up Drosophila melanogaster 99-105 21816165-0 2011 Transcriptional up-regulation of cell surface Na V 1.7 sodium channels by insulin-like growth factor-1 via inhibition of glycogen synthase kinase-3beta in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretion. Catecholamines 228-241 insulin like growth factor 1 Bos taurus 74-102 21816165-5 2011 In cells treated with IGF-1, veratridine-induced (22)Na(+) influx, and subsequent (45)Ca(2+) influx and catecholamine secretion were augmented by 35%, 33%, 31%, respectively. Catecholamines 104-117 insulin like growth factor 1 Bos taurus 22-27 21803145-1 2011 The activity of tyrosine hydroxylase (TH, EC 1.14.16.2) gene and protein determines the catecholamine level, which, in turn, is crucial for the organism homeostasis. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 16-36 21803145-1 2011 The activity of tyrosine hydroxylase (TH, EC 1.14.16.2) gene and protein determines the catecholamine level, which, in turn, is crucial for the organism homeostasis. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 38-40 21922189-0 2011 Enhanced catecholamine release in mice expressing PKB/SGK-resistant GSK3. Catecholamines 9-22 thymoma viral proto-oncogene 1 Mus musculus 50-53 21922189-0 2011 Enhanced catecholamine release in mice expressing PKB/SGK-resistant GSK3. Catecholamines 9-22 serum/glucocorticoid regulated kinase 1 Mus musculus 54-57 21922189-0 2011 Enhanced catecholamine release in mice expressing PKB/SGK-resistant GSK3. Catecholamines 9-22 glycogen synthase kinase 3 beta Mus musculus 68-72 21922189-14 2011 The observations reveal a completely novel function of PKB/Akt/SGK-dependent GSK3 signaling, i.e., regulation of catecholamine release. Catecholamines 113-126 thymoma viral proto-oncogene 1 Mus musculus 55-58 21922189-14 2011 The observations reveal a completely novel function of PKB/Akt/SGK-dependent GSK3 signaling, i.e., regulation of catecholamine release. Catecholamines 113-126 serum/glucocorticoid regulated kinase 1 Mus musculus 63-66 21922189-14 2011 The observations reveal a completely novel function of PKB/Akt/SGK-dependent GSK3 signaling, i.e., regulation of catecholamine release. Catecholamines 113-126 glycogen synthase kinase 3 beta Mus musculus 77-81 22136823-1 2011 BACKGROUND: Parathyroid hormone (PTH) secretion is partially regulated by circulating catecholamines. Catecholamines 86-100 parathyroid hormone Homo sapiens 12-31 22136823-1 2011 BACKGROUND: Parathyroid hormone (PTH) secretion is partially regulated by circulating catecholamines. Catecholamines 86-100 parathyroid hormone Homo sapiens 33-36 21906672-4 2011 In this report, we observed that plasma levels of angiotensin II and catecholamines were increased in KAP Tg mice, compared with wild-type animals. Catecholamines 69-83 kidney androgen regulated protein Mus musculus 102-105 21803077-8 2011 Lep group had hyperleptinemia (+19%), higher T4 (+20%) and T3 (+30%) with lower TSH (-55%), higher liver D1 (1.4 fold-increase), lower BAT D2 (-44%) and liver mGPD activities (-55%), higher adrenal catecholamines (+44%), lower hypothalamic OBR (-51%) and normal thyroid OBR. Catecholamines 198-212 leptin Rattus norvegicus 0-3 22001923-1 2011 Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in the biosynthesis of catecholamines, and its expression is regulated in a developmental stage- and cell type-specific manner. Catecholamines 87-101 tyrosine hydroxylase Homo sapiens 0-20 22001923-1 2011 Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in the biosynthesis of catecholamines, and its expression is regulated in a developmental stage- and cell type-specific manner. Catecholamines 87-101 tyrosine hydroxylase Homo sapiens 22-24 21617201-4 2011 These exogenous catecholamines engage membrane-bound beta(2)-adrenergic receptors (beta(2)AR) on airway epithelial and smooth muscle cells to cause airway dilation. Catecholamines 16-30 adrenoceptor beta 2 Homo sapiens 83-92 21871590-9 2011 In conclusion, TTC is associated with marked and persistent elevation of NT-proBNP/BNP levels, which correlated with both the extent of catecholamine increase and the severity of LV systolic dysfunction. Catecholamines 136-149 natriuretic peptide B Homo sapiens 79-82 22081025-2 2011 Catecholamines and Ang II activate the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), the inhibition of which prevents isoproterenol-mediated and Ang II-mediated cardiomyopathy. Catecholamines 0-14 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 55-100 22009377-7 2011 Moreover, subjects in the highest quartile of catecholamine-induced visceral lipolysis had higher levels of systolic blood pressure, estimated liver fat, plasma levels of glucose, insulin, cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B and lower whole-body insulin sensitivity than those in the lowest quartile (p=0.0004-0.048). Catecholamines 46-59 insulin Homo sapiens 180-187 22081025-2 2011 Catecholamines and Ang II activate the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), the inhibition of which prevents isoproterenol-mediated and Ang II-mediated cardiomyopathy. Catecholamines 0-14 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 102-108 22081025-2 2011 Catecholamines and Ang II activate the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), the inhibition of which prevents isoproterenol-mediated and Ang II-mediated cardiomyopathy. Catecholamines 0-14 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 171-177 21767631-11 2011 However, catecholamines inhibit release of IL-6 via alpha1-adrenergic pathways but without any effect on TGF-beta. Catecholamines 9-23 interleukin 6 Mus musculus 43-47 21745490-11 2011 However, the effects of catecholamines on insulin resistance may be due to their effects on adipoR2. Catecholamines 24-38 adiponectin receptor 2 Rattus norvegicus 92-99 21782946-8 2011 However, in both aged mice and in transgenic mice with increased expression of human alpha-synuclein we observe decreased phenotypic expression of the catecholamine synthetic enzyme tyrosine hydroxylase (TH) in dopaminergic axons and terminals in the striatum. Catecholamines 151-164 synuclein alpha Homo sapiens 85-100 21536121-4 2011 In the present study, we examined the effects of noradrenaline and adrenaline, stress-related catecholamines, on IL-33 production by dendritic cells (DCs). Catecholamines 94-108 interleukin 33 Mus musculus 113-118 22009377-7 2011 Moreover, subjects in the highest quartile of catecholamine-induced visceral lipolysis had higher levels of systolic blood pressure, estimated liver fat, plasma levels of glucose, insulin, cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B and lower whole-body insulin sensitivity than those in the lowest quartile (p=0.0004-0.048). Catecholamines 46-59 apolipoprotein B Homo sapiens 237-253 22009377-7 2011 Moreover, subjects in the highest quartile of catecholamine-induced visceral lipolysis had higher levels of systolic blood pressure, estimated liver fat, plasma levels of glucose, insulin, cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B and lower whole-body insulin sensitivity than those in the lowest quartile (p=0.0004-0.048). Catecholamines 46-59 insulin Homo sapiens 275-282 21697722-1 2011 The organic cation transporter 3 (OCT3, SLC22A3) contributes to the control of cardiac catecholamine concentrations and is important for the disposition and action of cationic drugs, such as metformin, in the myocardium. Catecholamines 87-100 OCTN3 Homo sapiens 4-32 21697722-1 2011 The organic cation transporter 3 (OCT3, SLC22A3) contributes to the control of cardiac catecholamine concentrations and is important for the disposition and action of cationic drugs, such as metformin, in the myocardium. Catecholamines 87-100 OCTN3 Homo sapiens 34-38 21697722-1 2011 The organic cation transporter 3 (OCT3, SLC22A3) contributes to the control of cardiac catecholamine concentrations and is important for the disposition and action of cationic drugs, such as metformin, in the myocardium. Catecholamines 87-100 solute carrier family 22 member 3 Homo sapiens 40-47 21907185-6 2011 The expression of catecholamine-synthesizing enzymes including tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DBH) were analyzed on mRNA and protein levels. Catecholamines 18-31 tyrosine hydroxylase Homo sapiens 63-83 21849533-13 2011 The density of the abutting TH-IR fibers on the surface of the GHRH perikarya suggests that these juxtapositions may be functional synapses, and thus, in addition to NPY, catecholamines may regulate GHRH secretion via direct synaptic mechanisms. Catecholamines 171-185 growth hormone releasing hormone Homo sapiens 63-67 21849533-13 2011 The density of the abutting TH-IR fibers on the surface of the GHRH perikarya suggests that these juxtapositions may be functional synapses, and thus, in addition to NPY, catecholamines may regulate GHRH secretion via direct synaptic mechanisms. Catecholamines 171-185 growth hormone releasing hormone Homo sapiens 199-203 21996211-1 2011 BACKGROUND: Renalase is an enzyme that catabolizes catecholamines such as adrenaline and noradrenaline in the circulation. Catecholamines 51-65 renalase, FAD dependent amine oxidase Homo sapiens 12-20 21907185-6 2011 The expression of catecholamine-synthesizing enzymes including tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DBH) were analyzed on mRNA and protein levels. Catecholamines 18-31 tyrosine hydroxylase Homo sapiens 85-87 21907185-6 2011 The expression of catecholamine-synthesizing enzymes including tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DBH) were analyzed on mRNA and protein levels. Catecholamines 18-31 dopamine beta-hydroxylase Homo sapiens 93-118 21907185-6 2011 The expression of catecholamine-synthesizing enzymes including tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DBH) were analyzed on mRNA and protein levels. Catecholamines 18-31 dopamine beta-hydroxylase Homo sapiens 120-123 21656904-1 2011 Catechol-O-methyltransferase (genetic locus, COMT) is a major enzyme involved in catecholamine metabolism and has been associated with numerous psychiatric phenotypes. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 0-28 21795689-0 2011 The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. Catecholamines 80-93 plasminogen receptor with a C-terminal lysine Rattus norvegicus 32-56 21795689-0 2011 The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. Catecholamines 80-93 plasminogen receptor with a C-terminal lysine Rattus norvegicus 58-67 21795689-2 2011 Here, we investigated the expression and subcellular localization of Plg-R(KT), a novel plasminogen receptor, and its role in catecholaminergic cell plasminogen activation and regulation of catecholamine release. Catecholamines 126-139 plasminogen receptor with a C-terminal lysine Rattus norvegicus 69-78 21795689-9 2011 In summary, Plg-R(KT) is present on the surface of catecholaminergic cells and functions to stimulate plasminogen activation and modulate catecholamine release. Catecholamines 51-64 plasminogen receptor with a C-terminal lysine Rattus norvegicus 12-21 21820436-4 2011 By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. Catecholamines 89-102 phospholipase C beta 1 Homo sapiens 168-188 21767616-1 2011 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated acutely by protein phosphorylation. Catecholamines 55-68 tyrosine hydroxylase Rattus norvegicus 0-20 21767616-1 2011 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated acutely by protein phosphorylation. Catecholamines 55-68 tyrosine hydroxylase Rattus norvegicus 22-24 21943293-5 2011 METHODS/DESIGN: The Project CRASH study is a federally supported, multicenter, prospective study designed to determine whether variations in genes affecting synaptic catecholamine levels and alpha and beta adrenergic receptor function augment social and psychological factors in a predictive model of persistent musculoskeletal pain and posttraumatic stress disorder (PTSD) following minor MVC. Catecholamines 166-179 asparaginase and isoaspartyl peptidase 1 Homo sapiens 28-33 21656904-1 2011 Catechol-O-methyltransferase (genetic locus, COMT) is a major enzyme involved in catecholamine metabolism and has been associated with numerous psychiatric phenotypes. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 45-49 21926888-1 2011 OBJECTIVE: : Vasopressin and its analog, terlipressin (TP), are potent vasopressors that may be useful therapeutic agents in the treatment of cardiac arrest (CA), septic and catecholamine-resistant shock, and esophageal variceal hemorrhage. Catecholamines 174-187 arginine vasopressin Homo sapiens 13-24 21543385-1 2011 AIMS: Catestatin (CST) is a chromogranin A (CgA)-derived peptide (hCgA352-372) with three identified human variants (G364S/P370L/R374Q-CST) that show differential potencies towards the inhibition of catecholamine release. Catecholamines 199-212 chromogranin A Homo sapiens 6-16 21543385-1 2011 AIMS: Catestatin (CST) is a chromogranin A (CgA)-derived peptide (hCgA352-372) with three identified human variants (G364S/P370L/R374Q-CST) that show differential potencies towards the inhibition of catecholamine release. Catecholamines 199-212 chromogranin A Homo sapiens 18-21 21677270-6 2011 Sry has been demonstrated to modulate the catecholamine pathway, so it should have functional consequences in the central and peripheral nervous system. Catecholamines 42-55 sex determining region Y Homo sapiens 0-3 21905812-8 2011 In addition to specific behaviours, dysregulation of the stress system through increased secretion of cortisol and catecholamines, especially in the evening hours, and in concert with concurrently elevated insulin concentrations, leads to development of central obesity, insulin resistance and the metabolic syndrome. Catecholamines 115-129 insulin Homo sapiens 271-278 21631898-2 2011 Data collected from both the clinical and basic research settings show that apelin: (i) is correlated with the states of insulin resistance and obesity; (ii) stimulates glucose utilization; (iii) decreases insulin secretion; and (iv) negatively regulates catecholamine-mediated lipolysis. Catecholamines 255-268 apelin Homo sapiens 76-82 21398662-4 2011 The catecholamine surge from the stress of surgery and resulting beta(2)-adrenergic signaling culminates in a transient and robust increased vascular endothelial growth factor expression locally and systemically that is enough to start tumor angiogenesis and end dormancy. Catecholamines 4-17 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 65-71 21398662-4 2011 The catecholamine surge from the stress of surgery and resulting beta(2)-adrenergic signaling culminates in a transient and robust increased vascular endothelial growth factor expression locally and systemically that is enough to start tumor angiogenesis and end dormancy. Catecholamines 4-17 vascular endothelial growth factor A Homo sapiens 141-175 21621591-0 2011 Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release. Catecholamines 160-173 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 86-124 21621591-0 2011 Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release. Catecholamines 160-173 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 126-131 21857681-8 2011 Here we elucidate a molecular mechanism by which beta-adrenergic catecholamines, acting through both Gs-PKA and beta-arrestin-mediated signalling pathways, trigger DNA damage and suppress p53 levels respectively, thus synergistically leading to the accumulation of DNA damage. Catecholamines 65-79 tumor protein p53 Homo sapiens 188-191 21784415-2 2011 In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepinephrine, but is uniquely expressed in a subset of dopaminergic (DAergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite. Catecholamines 56-70 aldehyde dehydrogenase 1 family member A1 Homo sapiens 14-21 21857681-10 2011 Catecholamine-induced DNA damage is abrogated in Arrb1-knockout (Arrb1(-/-)) mice, which show preserved p53 levels in both the thymus, an organ that responds prominently to acute or chronic stress, and in the testes, in which paternal stress may affect the offspring"s genome. Catecholamines 0-13 arrestin, beta 1 Mus musculus 49-54 21772125-3 2011 High catecholamine levels can directly damage the endothelium and may be associated with enhanced endothelial glycocalyx degradation, evidenced by high circulating syndecan-1. Catecholamines 5-18 syndecan 1 Homo sapiens 164-174 21857681-10 2011 Catecholamine-induced DNA damage is abrogated in Arrb1-knockout (Arrb1(-/-)) mice, which show preserved p53 levels in both the thymus, an organ that responds prominently to acute or chronic stress, and in the testes, in which paternal stress may affect the offspring"s genome. Catecholamines 0-13 arrestin, beta 1 Mus musculus 65-70 21857681-10 2011 Catecholamine-induced DNA damage is abrogated in Arrb1-knockout (Arrb1(-/-)) mice, which show preserved p53 levels in both the thymus, an organ that responds prominently to acute or chronic stress, and in the testes, in which paternal stress may affect the offspring"s genome. Catecholamines 0-13 transformation related protein 53, pseudogene Mus musculus 104-107 21772125-8 2011 RESULTS: Patients with high circulating syndecan-1 had higher catecholamines, IL-6, IL-10, histone-complexed DNA fragments, HMGB1, thrombomodulin, D-dimer, tPA, uPA (all P < 0.05), and 3-fold increased mortality (42% vs. 14%, P = 0.006) despite comparable ISS (P = 0.351). Catecholamines 62-76 syndecan 1 Homo sapiens 40-50 21311897-1 2011 BACKGROUND: The beta(1)-adrenoceptor (beta(1)AR) mediates cardiostimulatory effects of catecholamines in the heart. Catecholamines 87-101 adrenoceptor beta 1 Homo sapiens 16-36 21551321-1 2011 BACKGROUND: The secretory protein chromogranin A (CHGA) plays a necessary role in formation of catecholamine storage vesicles and gives rise to a catecholamine release-inhibitory fragment. Catecholamines 95-108 chromogranin A Homo sapiens 34-48 21551321-1 2011 BACKGROUND: The secretory protein chromogranin A (CHGA) plays a necessary role in formation of catecholamine storage vesicles and gives rise to a catecholamine release-inhibitory fragment. Catecholamines 95-108 chromogranin A Homo sapiens 50-54 21551321-1 2011 BACKGROUND: The secretory protein chromogranin A (CHGA) plays a necessary role in formation of catecholamine storage vesicles and gives rise to a catecholamine release-inhibitory fragment. Catecholamines 146-159 chromogranin A Homo sapiens 34-48 21551321-1 2011 BACKGROUND: The secretory protein chromogranin A (CHGA) plays a necessary role in formation of catecholamine storage vesicles and gives rise to a catecholamine release-inhibitory fragment. Catecholamines 146-159 chromogranin A Homo sapiens 50-54 21311897-1 2011 BACKGROUND: The beta(1)-adrenoceptor (beta(1)AR) mediates cardiostimulatory effects of catecholamines in the heart. Catecholamines 87-101 adrenoceptor beta 1 Homo sapiens 38-47 21311897-2 2011 The Arg389Gly polymorphism of the beta(1)AR gene has recently been shown to determine the responsiveness to catecholamines in vitro, and we previously reported that dobutamine induced an augmented contractile response in humans homozygous for the Arg389 allele. Catecholamines 108-122 adrenoceptor beta 1 Homo sapiens 34-43 21601990-0 2011 Personality traits of aggression-submissiveness and perfectionism associate with ABO blood groups through catecholamine activities. Catecholamines 106-119 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 81-84 21864755-21 2011 In very high intensity exercise (about 80% of VO(2 max)) or when high intensity exercise follows a low intensity one, there is a tendency of the BG to increase due to excessive circulating catecholamines necessitating postexercise short acting insulin. Catecholamines 189-203 insulin Homo sapiens 244-251 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 dopamine beta-hydroxylase Homo sapiens 125-150 21494253-0 2011 Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells. Catecholamines 63-77 chemokine (C-X-C motif) receptor 4 Mus musculus 93-98 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 dopamine beta-hydroxylase Homo sapiens 152-155 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 158-186 21494253-0 2011 Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells. Catecholamines 63-77 chemokine (C-X-C motif) ligand 12 Mus musculus 109-114 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 188-192 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 monoamine oxidase A Homo sapiens 199-218 21601990-1 2011 Personality trait research has shown associations with many genes, prominently those of the catecholamine metabolism such as dopamine beta hydroxylase (DBH), catechol-O-methyltransferase (COMT), and monoamine oxidase A (MAOA). Catecholamines 92-105 monoamine oxidase A Homo sapiens 220-224 21601990-2 2011 Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that other catecholamine genes using the same substrate as DBH may also have associations with ABO blood groups, and this paper demonstrates how this may be so. Catecholamines 97-110 dopamine beta-hydroxylase Homo sapiens 8-11 21601990-2 2011 Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that other catecholamine genes using the same substrate as DBH may also have associations with ABO blood groups, and this paper demonstrates how this may be so. Catecholamines 97-110 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 51-54 21601990-2 2011 Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that other catecholamine genes using the same substrate as DBH may also have associations with ABO blood groups, and this paper demonstrates how this may be so. Catecholamines 97-110 dopamine beta-hydroxylase Homo sapiens 145-148 21601990-2 2011 Because DBH gene is in linkage disequilibrium with ABO gene, there is reason to think that other catecholamine genes using the same substrate as DBH may also have associations with ABO blood groups, and this paper demonstrates how this may be so. Catecholamines 97-110 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 181-184 21601990-4 2011 If ABO blood groups can be demonstrated to associate with all these catecholamine genes, then the catecholamine personality trait research can be applied to ABO blood groups and tested for confirmation. Catecholamines 68-81 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 3-6 21601990-4 2011 If ABO blood groups can be demonstrated to associate with all these catecholamine genes, then the catecholamine personality trait research can be applied to ABO blood groups and tested for confirmation. Catecholamines 68-81 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 157-160 21601990-4 2011 If ABO blood groups can be demonstrated to associate with all these catecholamine genes, then the catecholamine personality trait research can be applied to ABO blood groups and tested for confirmation. Catecholamines 98-111 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 3-6 21601990-4 2011 If ABO blood groups can be demonstrated to associate with all these catecholamine genes, then the catecholamine personality trait research can be applied to ABO blood groups and tested for confirmation. Catecholamines 98-111 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 157-160 21601990-5 2011 ABO blood typing is widely available and affords ability to test this hypothesis and thus confirm the possible joint association of personality traits of aggression-submissiveness and perfectionism to catecholamine genes and to ABO blood groups. Catecholamines 201-214 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 0-3 21540292-6 2011 In vitro experiments using purified enzymes showed that catecholamines inhibited CPE, PC1/3, and PC2, with dopamine quinone the most potent inhibitor (IC(50) values of ~50-500 muM); dopamine, norepinephrine, and epinephrine exhibited inhibition in the micromolar range. Catecholamines 56-70 carboxypeptidase E Rattus norvegicus 81-84 21540292-6 2011 In vitro experiments using purified enzymes showed that catecholamines inhibited CPE, PC1/3, and PC2, with dopamine quinone the most potent inhibitor (IC(50) values of ~50-500 muM); dopamine, norepinephrine, and epinephrine exhibited inhibition in the micromolar range. Catecholamines 56-70 proprotein convertase subtilisin/kexin type 1 Rattus norvegicus 86-91 21540292-6 2011 In vitro experiments using purified enzymes showed that catecholamines inhibited CPE, PC1/3, and PC2, with dopamine quinone the most potent inhibitor (IC(50) values of ~50-500 muM); dopamine, norepinephrine, and epinephrine exhibited inhibition in the micromolar range. Catecholamines 56-70 proprotein convertase subtilisin/kexin type 2 Rattus norvegicus 97-100 21540292-7 2011 The inhibition of purified CPE with catecholamines was time-dependent and, for dopamine quinone, dilution-independent, suggesting covalent modification of the protein by the catecholamine. Catecholamines 36-50 carboxypeptidase E Rattus norvegicus 27-30 21540292-7 2011 The inhibition of purified CPE with catecholamines was time-dependent and, for dopamine quinone, dilution-independent, suggesting covalent modification of the protein by the catecholamine. Catecholamines 36-49 carboxypeptidase E Rattus norvegicus 27-30 21540292-8 2011 Because the catecholamine concentrations found to be inhibitory to PC1/3, PC2, and CPE are well within the physiological range found in chromaffin granules, we conclude that catecholaminergic transmitter systems have the potential to exert considerable dynamic influence over peptidergic transmitter synthesis by altering the activity of peptide processing enzymes. Catecholamines 12-25 proprotein convertase subtilisin/kexin type 1 Rattus norvegicus 67-72 21540292-8 2011 Because the catecholamine concentrations found to be inhibitory to PC1/3, PC2, and CPE are well within the physiological range found in chromaffin granules, we conclude that catecholaminergic transmitter systems have the potential to exert considerable dynamic influence over peptidergic transmitter synthesis by altering the activity of peptide processing enzymes. Catecholamines 12-25 proprotein convertase subtilisin/kexin type 2 Rattus norvegicus 74-77 21540292-8 2011 Because the catecholamine concentrations found to be inhibitory to PC1/3, PC2, and CPE are well within the physiological range found in chromaffin granules, we conclude that catecholaminergic transmitter systems have the potential to exert considerable dynamic influence over peptidergic transmitter synthesis by altering the activity of peptide processing enzymes. Catecholamines 12-25 carboxypeptidase E Rattus norvegicus 83-86 21680895-4 2011 METHODS AND RESULTS: Flecainide prevented catecholamine-induced sustained ventricular tachycardia in RyR2(R4496C+/-) mice. Catecholamines 42-55 ryanodine receptor 2, cardiac Mus musculus 101-105 21486747-1 2011 Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. Catecholamines 66-79 catechol-O-methyltransferase Homo sapiens 0-28 21486747-1 2011 Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. Catecholamines 66-79 catechol-O-methyltransferase Homo sapiens 30-34 21740891-6 2011 This result indicates that the interaction of PMCA4 with calcineurin A plays a regulatory role in the signalling during catecholamine secretion. Catecholamines 120-133 ATPase plasma membrane Ca2+ transporting 4 Rattus norvegicus 46-51 21777743-10 2011 In the context of HF, catecholamines and aldosterone both down-regulated Tfr1 expression in isolated cardiomyocytes. Catecholamines 22-36 transferrin receptor Homo sapiens 73-77 21597914-0 2011 Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin. Catecholamines 0-13 secretin Rattus norvegicus 87-95 21508290-11 2011 Overexpression of avian UCP3 might modulate energy utilization or limit oxidative stress when mitochondrial metabolism of FA is triggered by catecholamines. Catecholamines 141-155 uncoupling protein 3 Gallus gallus 24-28 21597914-2 2011 We tested whether secretin belonging to the glucagon/PACAP/VIP superfamily would increase transcription of the tyrosine hydroxylase (Th) gene and modulate catecholamine secretion. Catecholamines 155-168 secretin Rattus norvegicus 18-26 21597914-2 2011 We tested whether secretin belonging to the glucagon/PACAP/VIP superfamily would increase transcription of the tyrosine hydroxylase (Th) gene and modulate catecholamine secretion. Catecholamines 155-168 adenylate cyclase activating polypeptide 1 Rattus norvegicus 53-58 21597914-2 2011 We tested whether secretin belonging to the glucagon/PACAP/VIP superfamily would increase transcription of the tyrosine hydroxylase (Th) gene and modulate catecholamine secretion. Catecholamines 155-168 vasoactive intestinal peptide Rattus norvegicus 59-62 21597914-6 2011 Secretin stimulated catecholamine secretion (EC(50) ~3.5 muM) from PC12 cells, but this was inhibited by pre-treatment with VIP-preferring receptor (VPAC1)/PACAP-preferring receptor (PAC1) antagonists. Catecholamines 20-33 secretin Rattus norvegicus 0-8 21597914-6 2011 Secretin stimulated catecholamine secretion (EC(50) ~3.5 muM) from PC12 cells, but this was inhibited by pre-treatment with VIP-preferring receptor (VPAC1)/PACAP-preferring receptor (PAC1) antagonists. Catecholamines 20-33 vasoactive intestinal peptide Rattus norvegicus 124-127 21597914-6 2011 Secretin stimulated catecholamine secretion (EC(50) ~3.5 muM) from PC12 cells, but this was inhibited by pre-treatment with VIP-preferring receptor (VPAC1)/PACAP-preferring receptor (PAC1) antagonists. Catecholamines 20-33 adenylate cyclase activating polypeptide 1 Rattus norvegicus 156-161 21597914-8 2011 Secretin augmented phospholipase C (PLC) activity and increased inositol-1,4,5-triphosphate (IP(3)) levels in PC12 cells; PLC-beta inhibition blocked secretin-induced catecholamine secretion, indicating the participation of intracellular Ca(2+) from a phospholipase pathway in secretion. Catecholamines 167-180 secretin Rattus norvegicus 0-8 21597914-8 2011 Secretin augmented phospholipase C (PLC) activity and increased inositol-1,4,5-triphosphate (IP(3)) levels in PC12 cells; PLC-beta inhibition blocked secretin-induced catecholamine secretion, indicating the participation of intracellular Ca(2+) from a phospholipase pathway in secretion. Catecholamines 167-180 secretin Rattus norvegicus 150-158 21597914-9 2011 Like PACAP, secretin evoked long-lasting catecholamine secretion, even after only a transient exposure. Catecholamines 41-54 secretin Rattus norvegicus 12-20 21486391-1 2011 One of the candidate genes for suicide is also a gene in the pathway for catecholamine degradation encoding an enzyme catechol-O-methyl-transferase (COMT). Catecholamines 73-86 catechol-O-methyltransferase Homo sapiens 118-147 21486391-1 2011 One of the candidate genes for suicide is also a gene in the pathway for catecholamine degradation encoding an enzyme catechol-O-methyl-transferase (COMT). Catecholamines 73-86 catechol-O-methyltransferase Homo sapiens 149-153 21397335-1 2011 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 21397335-1 2011 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 21397335-1 2011 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 104-108 21488089-6 2011 Transcripts encoding the catecholamine biosynthetic enzyme dopamine-beta-hydroxylase were unaffected by acute NPH but were diminished by serial insulin dosing. Catecholamines 25-38 dopamine beta-hydroxylase Homo sapiens 59-84 21447540-3 2011 The catechol-O-methyltransferase (COMT) gene, located within the deleted region, encodes for the enzyme COMT that is important for degradation of catecholamines, including dopamine (DA). Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 4-32 21355050-3 2011 Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine and estrogen degradation and has recently been ascribed a role in development of preeclampsia. Catecholamines 61-74 catechol-O-methyltransferase Mus musculus 0-28 21355050-3 2011 Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine and estrogen degradation and has recently been ascribed a role in development of preeclampsia. Catecholamines 61-74 catechol-O-methyltransferase Mus musculus 30-34 21447540-3 2011 The catechol-O-methyltransferase (COMT) gene, located within the deleted region, encodes for the enzyme COMT that is important for degradation of catecholamines, including dopamine (DA). Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 34-38 21447540-3 2011 The catechol-O-methyltransferase (COMT) gene, located within the deleted region, encodes for the enzyme COMT that is important for degradation of catecholamines, including dopamine (DA). Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 104-108 21624345-2 2011 MAO-A is a key enzyme regulating the catabolism of catecholamine neurotransmitters in the brain. Catecholamines 51-64 monoamine oxidase A Mus musculus 0-5 20937529-1 2011 Serotonin and catecholamine system studies provide increasing evidence for the importance of genetic factors in obsessive-compulsive disorder (OCD); we found that genetic linkage disequilibrium with OCD existed in the 5-HT2A-receptor promoter polymorphism -1438G/A. Catecholamines 14-27 5-hydroxytryptamine receptor 2A Homo sapiens 218-233 21596853-0 2011 The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Catecholamines 106-119 serpin family E member 1 Rattus norvegicus 30-63 21596853-0 2011 The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Catecholamines 106-119 serpin family E member 1 Rattus norvegicus 65-70 21596853-5 2011 Sucrose gradient fractionation studies and immunoelectron microscopy demonstrated localization of PAI-1 to catecholamine storage vesicles. Catecholamines 107-120 serpin family E member 1 Rattus norvegicus 98-103 21596853-6 2011 Secretogogue stimulation resulted in corelease of PAI-1 with catecholamines. Catecholamines 61-75 serpin family E member 1 Rattus norvegicus 50-55 21596853-10 2011 Modulation of PAI-1 levels by incubating PC12 cells with anti-PAI-1 IgG caused a marked decrease in nicotine-mediated catecholamine release. Catecholamines 118-131 serpin family E member 1 Rattus norvegicus 14-19 21596853-10 2011 Modulation of PAI-1 levels by incubating PC12 cells with anti-PAI-1 IgG caused a marked decrease in nicotine-mediated catecholamine release. Catecholamines 118-131 serpin family E member 1 Rattus norvegicus 62-67 21596853-11 2011 In summary, PAI-1 is expressed in chromaffin cells, sorted into the regulated pathway of secretion (into catecholamine storage vesicles), and coreleased, by exocytosis, with catecholamines in response to secretogogues. Catecholamines 105-118 serpin family E member 1 Rattus norvegicus 12-17 21596853-11 2011 In summary, PAI-1 is expressed in chromaffin cells, sorted into the regulated pathway of secretion (into catecholamine storage vesicles), and coreleased, by exocytosis, with catecholamines in response to secretogogues. Catecholamines 174-188 serpin family E member 1 Rattus norvegicus 12-17 21645870-7 2011 Acute NOS inhibition led to an instantaneous recovery of the inotropic response to catecholamines in tg-iNOS mice. Catecholamines 83-97 nitric oxide synthase 2, inducible Mus musculus 101-108 21622221-4 2011 In the heart, the major GRK isoforms, GRK2 and GRK5, undergo upregulation due to the heightened sympathetic nervous system activity that is characteristic of HF as catecholamine levels increase in an effort to drive the failing pump. Catecholamines 164-177 G protein-coupled receptor kinase 5 Homo sapiens 24-27 21622221-4 2011 In the heart, the major GRK isoforms, GRK2 and GRK5, undergo upregulation due to the heightened sympathetic nervous system activity that is characteristic of HF as catecholamine levels increase in an effort to drive the failing pump. Catecholamines 164-177 G protein-coupled receptor kinase 5 Homo sapiens 47-51 21622221-4 2011 In the heart, the major GRK isoforms, GRK2 and GRK5, undergo upregulation due to the heightened sympathetic nervous system activity that is characteristic of HF as catecholamine levels increase in an effort to drive the failing pump. Catecholamines 164-177 G protein-coupled receptor kinase 2 Homo sapiens 38-42 21396710-0 2011 A putative morphological substrate of the catecholamine-influenced neuropeptide Y (NPY) release in the human hypothalamus. Catecholamines 42-55 neuropeptide Y Homo sapiens 67-81 21400210-0 2011 Catecholamine-resistant shock and hypoglycemic coma after cardiotomy in a patient with unexpected isolated ACTH deficiency. Catecholamines 0-13 proopiomelanocortin Homo sapiens 107-111 21625261-0 2011 Does renalase degrade catecholamines? Catecholamines 22-36 renalase, FAD dependent amine oxidase Homo sapiens 5-13 21402762-0 2011 Staphylococcus aureus transporters Hts, Sir, and Sst capture iron liberated from human transferrin by Staphyloferrin A, Staphyloferrin B, and catecholamine stress hormones, respectively, and contribute to virulence. Catecholamines 142-155 transferrin Homo sapiens 87-98 21402762-4 2011 It is also established that catecholamine hormones can interfere with the iron-binding properties of transferrin, thus allowing infectious bacteria access to this iron pool. Catecholamines 28-41 transferrin Homo sapiens 101-112 21396710-0 2011 A putative morphological substrate of the catecholamine-influenced neuropeptide Y (NPY) release in the human hypothalamus. Catecholamines 42-55 neuropeptide Y Homo sapiens 83-86 21396710-3 2011 In the present study, we examined, with morphological means, the possibility that catecholamines directly influence NPY release in the human hypothalamus. Catecholamines 82-96 neuropeptide Y Homo sapiens 116-119 21396710-9 2011 Since catecholamines are known to be the crucial components of the stress response, the presence of direct, catecholaminergic (primarily dopaminergic)-NPY-IR synapses may explain the increased NPY release during stress. Catecholamines 6-20 neuropeptide Y Homo sapiens 151-154 21396710-9 2011 Since catecholamines are known to be the crucial components of the stress response, the presence of direct, catecholaminergic (primarily dopaminergic)-NPY-IR synapses may explain the increased NPY release during stress. Catecholamines 6-20 neuropeptide Y Homo sapiens 193-196 21093063-3 2011 We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines. Catecholamines 398-412 glutathione S-transferase mu 1 Homo sapiens 75-80 21093063-3 2011 We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines. Catecholamines 398-412 glutathione S-transferase theta 1 Homo sapiens 144-149 20715173-2 2011 Recently, stress-induced catecholamines have been shown to increase the expression of various cancer progressive factors, including vascular endothelial growth factor (VEGF), matrix metalloproteinases and interleukins. Catecholamines 25-39 vascular endothelial growth factor A Homo sapiens 132-166 21609470-9 2011 CONCLUSIONS: We have identified that the level of catecholamines and serotonin is differentially affected in Mecp2(-/y) brain areas in a time-dependent fashion. Catecholamines 50-64 methyl CpG binding protein 2 Mus musculus 109-114 20715173-2 2011 Recently, stress-induced catecholamines have been shown to increase the expression of various cancer progressive factors, including vascular endothelial growth factor (VEGF), matrix metalloproteinases and interleukins. Catecholamines 25-39 vascular endothelial growth factor A Homo sapiens 168-172 20715173-4 2011 In this study, we investigated the role of adrenergic receptors and hypoxia-inducible factor (HIF)-1alpha protein in catecholamine-induced VEGF expression and angiogenesis. Catecholamines 117-130 hypoxia inducible factor 1 subunit alpha Homo sapiens 68-105 20715173-4 2011 In this study, we investigated the role of adrenergic receptors and hypoxia-inducible factor (HIF)-1alpha protein in catecholamine-induced VEGF expression and angiogenesis. Catecholamines 117-130 vascular endothelial growth factor A Homo sapiens 139-143 21780643-1 2011 The work studied vasopressinergic neurons of hypothalamic supraoptic and paravenricular nuclei of the wild type mice and the neuronal nitric oxide synthase (nNOS) gene knockouted mice at a decrease of the brain catecholamine (CA) level caused by administration of the blocker of activity of tyrosine hydroxylase alpha-methyl-paratyrosine (alpha-MPT) and at the CA level decrease on the background of functional activity of the vasopressinergic neurons caused by dehydration of animals. Catecholamines 211-224 nitric oxide synthase 1, neuronal Mus musculus 125-155 21267513-8 2011 Multivariate analysis with change in parasympathetic activity and catecholamines, while controlling for age and use of beta-blockers, revealed a significant odds ratio (OR = 3.27, 95% CI 1.03, 10.41 P = 0.04) for an increase in ET-1 associated with parasympathetic withdrawal; no other variables were significant. Catecholamines 66-80 endothelin 1 Homo sapiens 228-232 20801543-9 2011 This reduced suppression of insulin sensitivity in critically ill patients could be a result of saturation due to already increased levels of catecholamines and cortisol common in critically illness. Catecholamines 142-156 insulin Homo sapiens 28-35 21330041-1 2011 AIM OF THE STUDY: In comparison to adrenaline, administration of vasopressin increases adrenal gland perfusion, but decreases catecholamine plasma concentrations when compared to saline placebo. Catecholamines 126-139 vasopressin Sus scrofa 65-76 21780643-1 2011 The work studied vasopressinergic neurons of hypothalamic supraoptic and paravenricular nuclei of the wild type mice and the neuronal nitric oxide synthase (nNOS) gene knockouted mice at a decrease of the brain catecholamine (CA) level caused by administration of the blocker of activity of tyrosine hydroxylase alpha-methyl-paratyrosine (alpha-MPT) and at the CA level decrease on the background of functional activity of the vasopressinergic neurons caused by dehydration of animals. Catecholamines 211-224 nitric oxide synthase 1, neuronal Mus musculus 157-161 21412235-5 2011 tyra-3 acts in sensory neurons that detect environmental cues, suggesting that the internal catecholamines detected by tyra-3 regulate responses to external conditions. Catecholamines 92-106 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 0-6 21412235-5 2011 tyra-3 acts in sensory neurons that detect environmental cues, suggesting that the internal catecholamines detected by tyra-3 regulate responses to external conditions. Catecholamines 92-106 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 119-125 21330599-0 2011 cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes. Catecholamines 79-92 cathelicidin antimicrobial peptide Rattus norvegicus 22-26 21159454-2 2011 Excessive amounts of catecholamines released from sympathetic nerve endings as well as from the adrenal medulla under stressful conditions are considered to produce intracellular Ca(2+) overload and cardiac dysfunction through the beta(1)-adrenoceptor signal transduction pathway. Catecholamines 21-35 adrenoceptor beta 1 Homo sapiens 231-251 21330599-3 2011 OBJECTIVE: To study the effect of cGMP signals on the local cAMP response to catecholamines in specific subcellular compartments. Catecholamines 77-91 cathelicidin antimicrobial peptide Rattus norvegicus 60-64 21176768-1 2011 Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Catecholamines 52-65 tyrosine hydroxylase Homo sapiens 0-20 21412203-2 2011 NET-deficient transgenic mice have elevated blood pressure (BP), heart rate, and catecholamine concentrations. Catecholamines 81-94 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 0-3 20675056-5 2011 High levels of chromogranin A, that is co-stored and co-secreted with catecholamines, may indicate tumour mass and malignancy and can be used to monitor response and relapse. Catecholamines 70-84 chromogranin A Homo sapiens 15-29 22468040-0 2011 Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production. Catecholamines 26-40 epidermal growth factor receptor Homo sapiens 152-184 21178975-2 2011 Levels of renalase, a recently discovered oxidase that metabolizes catecholamines, are decreased in CKD. Catecholamines 67-81 renalase, FAD-dependent amine oxidase Mus musculus 10-18 21178975-9 2011 In vitro studies confirmed that renalase metabolizes NADH and catecholamines. Catecholamines 62-76 renalase, FAD-dependent amine oxidase Mus musculus 32-40 22468040-9 2011 This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Catecholamines 49-63 parathyroid hormone Homo sapiens 106-109 22468040-9 2011 This study confirms a strong association between catecholamines as well as EGF-R/HER-1/erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Catecholamines 49-63 fibrinogen beta chain Homo sapiens 186-206 21255940-4 2011 Patients with CIAP usually suffer from chronic pain and associated depression, both of which have been proposed to cause insulin resistance (IR) by such mechanisms as a sustained increase in the corticosteroids and catecholamines, and chronic low grade inflammation. Catecholamines 215-229 insulin Homo sapiens 121-128 21253815-0 2011 The role of vasopressin and terlipressin in catecholamine-resistant shock and cardio-circulatory arrest in children: review of the literature. Catecholamines 44-57 arginine vasopressin Homo sapiens 12-23 20730801-10 2011 Inhibition of catecholamine synthesis by alpha-methyl-DL-tyrosine (AMPT) increased DRD2 expression and prevented further increase by APs. Catecholamines 14-27 dopamine receptor D2 Homo sapiens 83-87 21368060-0 2011 Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus. Catecholamines 49-62 ghrelin Mus musculus 0-7 21302933-1 2011 Phosphorylation of Ser40 in the regulatory domain of tyrosine hydroxylase activates the enzyme by increasing the rate constant for dissociation of inhibitory catecholamines from the active site by 3 orders of magnitude. Catecholamines 158-172 tyrosine hydroxylase Homo sapiens 53-73 21437260-1 2011 BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 16-44 21437260-1 2011 BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 46-50 21302344-3 2011 We hypothesized that 5HTTLPR genotype would show little association with prefrontal cognitive performance, but that COMT and MAOA would have interacting effects on cognition through their shared influence on prefrontal catecholamine availability. Catecholamines 219-232 catechol-O-methyltransferase Homo sapiens 116-120 21193587-2 2011 Under stress when catecholamine levels are high, enhanced Na(+)-K(+)-ATPase activity by phosphorylated PLM attenuates intracellular Na(+) concentration ([Na(+)](i)) overload. Catecholamines 18-31 FXYD domain-containing ion transport regulator 1 Mus musculus 103-106 21302344-3 2011 We hypothesized that 5HTTLPR genotype would show little association with prefrontal cognitive performance, but that COMT and MAOA would have interacting effects on cognition through their shared influence on prefrontal catecholamine availability. Catecholamines 219-232 monoamine oxidase A Homo sapiens 125-129 21193587-14 2011 We conclude that under catecholamine stress when [Na(+)](i) is high, PLM minimizes [Na(+)](i) overload by relieving its inhibition of Na(+)-K(+)-ATPase and preserves inotropy by simultaneously inhibiting Na(+)/Ca(2+) exchanger. Catecholamines 23-36 FXYD domain-containing ion transport regulator 1 Mus musculus 69-72 21302344-6 2011 In boys but not girls, there was a modest but statistically significant interaction between MAOA and COMT genotypes such that increased prefrontal catecholamine availability was associated with better working memory. Catecholamines 147-160 monoamine oxidase A Homo sapiens 92-96 21302344-6 2011 In boys but not girls, there was a modest but statistically significant interaction between MAOA and COMT genotypes such that increased prefrontal catecholamine availability was associated with better working memory. Catecholamines 147-160 catechol-O-methyltransferase Homo sapiens 101-105 32938076-6 2011 The limits of detection for the catecholamine were 0.2 ng mL-1. Catecholamines 32-45 L1 cell adhesion molecule Mus musculus 58-62 21262951-1 2011 BACKGROUND: Pheochromocytomas are rare catecholamine-producing tumors derived in more than 30% of cases from mutations in 9 tumor-susceptibility genes identified to date, including von Hippel-Lindau tumor suppressor (VHL); succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB); and succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD). Catecholamines 39-52 von Hippel-Lindau tumor suppressor Homo sapiens 181-215 21075199-7 2011 Both DVC inactivation and catecholamine lesion prevented reductions in exploratory behavior and completely blocked the inhibitory LPS effects on c-Fos expression in the behavior-associated regions. Catecholamines 26-39 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 145-150 21091648-7 2011 Inhibition of either PDE3 or PDE4 (by milrinone and rolipram, respectively) potentiated the automatic response of myocytes to catecholamines. Catecholamines 126-140 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 21-25 21121973-5 2011 Nicotinic receptor activation resulted in a time- and concentration-dependent increase in catecholamine synthesis, which was significantly reduced by the extracellular signal-regulated kinase (ERK)1/2 signalling pathway inhibitor PD98059 and the calcium/calmodulin protein kinase II inhibitor KN-93, but not by H89 or bisindolylmaleimide I, inhibitors of protein kinase A and C, respectively. Catecholamines 90-103 mitogen-activated protein kinase 3 Bos taurus 154-200 21282370-3 2011 RESEARCH DESIGN AND METHODS: PTRF expression was examined in different adipose depots of mice during fasting, refeeding, and after administration of catecholamines and insulin. Catecholamines 149-163 caveolae associated 1 Mus musculus 29-33 21377081-5 2011 Vasopressin, a catecholamine-sparing vasopressor and antidiuretic agent, may be an effective agent in the treatment of refractory hypotension after brain death prior to organ transplantation. Catecholamines 15-28 arginine vasopressin Homo sapiens 0-11 21220710-2 2011 We hypothesize that the transcription factor nuclear factor kappa B (NFkappaB) is overexpressed in the SHR, enhancing its MMP activity and enzymatic cleavage of the beta2 adrenergic receptor (beta2AR), thereby diminishing catecholamine-mediated arteriolar vasodilation. Catecholamines 222-235 adrenoceptor beta 2 Rattus norvegicus 192-199 21270255-1 2011 OBJECTIVE: To examine the role of AMP-activated protein kinase (AMPK) in the control of glucoprivic feeding by hindbrain catecholamine neurons. Catecholamines 121-134 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 34-62 21270255-1 2011 OBJECTIVE: To examine the role of AMP-activated protein kinase (AMPK) in the control of glucoprivic feeding by hindbrain catecholamine neurons. Catecholamines 121-134 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 64-68 21087208-1 2011 TH (tyrosine hydroxylase) is the rate-limiting enzyme in the synthesis of catecholamines. Catecholamines 74-88 tyrosine hydroxylase Homo sapiens 4-24 21299895-6 2011 RESULTS: Both the agonist-induced phosphorylation and agonist-dependent desensitization of the human Glu301-303 deletion polymorphic alpha2B-AR are significantly impaired in PC12 cells, resulting in enhanced signaling to inhibition of cholinergic-induced catecholamine secretion in vitro. Catecholamines 255-268 adrenoceptor alpha 2B Homo sapiens 133-143 21345315-0 2011 PKC inhibitors RO 31-8220 and Go 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation. Catecholamines 90-103 AKT serine/threonine kinase 1 Homo sapiens 143-146 21062377-6 2011 Consistent with rodent studies, it was recently demonstrated that humans with MC4R deficiency have lower blood pressure, less hypertension, lower 24-h urinary catecholamine excretion, lower resting heart rate and attenuated insulin-mediated sympathetic activation compared to equally-obese humans. Catecholamines 159-172 melanocortin 4 receptor Homo sapiens 78-82 21127260-8 2011 These findings demonstrate that stress-induced elevations of salivary catecholamines signal through MAPK pathways, and result in impaired oral keratinocyte migration required for healing. Catecholamines 70-84 mitogen-activated protein kinase 3 Homo sapiens 100-104 21097823-7 2011 This catecholamine-mediated increase in FSP27 abundance, probably a feedback mechanism for restraining excessive lipolysis by catecholamines, is mimicked by forskolin or 8-bromo-cAMP treatment and is prevented by the protein kinase A (PKA) inhibitor KT5720 or by PKA depletion using siRNA. Catecholamines 5-18 cell death-inducing DFFA-like effector c Mus musculus 40-45 21097823-7 2011 This catecholamine-mediated increase in FSP27 abundance, probably a feedback mechanism for restraining excessive lipolysis by catecholamines, is mimicked by forskolin or 8-bromo-cAMP treatment and is prevented by the protein kinase A (PKA) inhibitor KT5720 or by PKA depletion using siRNA. Catecholamines 126-140 cell death-inducing DFFA-like effector c Mus musculus 40-45 20596792-9 2011 These results indicate that continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension in this animal model and suggests that increases in autonomic nervous activity induced by ghrelin receptor antagonism are responsible, as indicated by the high expression levels of genes in the catecholamine biosynthetic pathway. Catecholamines 326-339 growth hormone secretagogue receptor Rattus norvegicus 57-73 20725062-3 2011 Epigallocatechin-3-gallate (EGCG: the most bioactive catechin in green tea) inhibits catechol-O-methyltransferase, an enzyme contributing to the degradation of catecholamines. Catecholamines 160-174 catechol-O-methyltransferase Homo sapiens 85-113 21129429-3 2011 Tyrosine hydroxylase, a crucial enzyme in catecholamine biosynthesis, is tightly regulated by short- and long-term mechanisms. Catecholamines 42-55 tyrosine hydroxylase Rattus norvegicus 0-20 21166807-2 2011 While membrane potential changes or neuronal activity regulates tyrosine hydroxylase (TH, the rate limiting enzyme in catecholamine synthesis) expression in other catecholaminergic cells, it is not known whether the same occurs in adult SNc neurons. Catecholamines 118-131 tyrosine hydroxylase Mus musculus 64-84 21166807-2 2011 While membrane potential changes or neuronal activity regulates tyrosine hydroxylase (TH, the rate limiting enzyme in catecholamine synthesis) expression in other catecholaminergic cells, it is not known whether the same occurs in adult SNc neurons. Catecholamines 118-131 tyrosine hydroxylase Mus musculus 86-88 21070834-3 2011 We demonstrate that all catecholamines inhibit vesicle trafficking and secretion of leptin and resistin through beta-adrenergic receptors, while leptin and resistin enhance the vesicle trafficking and secretion of catecholamines through PKC, PKA, MAPK kinase and Ca(2+) dependent pathways. Catecholamines 214-228 protein kinase C, gamma Rattus norvegicus 237-240 20936939-5 2011 Renin release is acutely increased via the cAMP signaling pathway, which is triggered mainly by catecholamines and other G(s)-coupled agonists, and is inhibited by calcium-related pathways that are commonly activated by vasoconstrictors. Catecholamines 96-110 renin Homo sapiens 0-5 20814407-1 2011 BACKGROUND: Dopamine beta-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine. Catecholamines 75-88 dopamine beta-hydroxylase Homo sapiens 12-37 20814407-1 2011 BACKGROUND: Dopamine beta-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine. Catecholamines 75-88 dopamine beta-hydroxylase Homo sapiens 39-42 21035322-0 2011 High-performance amperometric biosensors and biofuel cell based on chitosan-strengthened cast thin films of chemically synthesized catecholamine polymers with glucose oxidase effectively entrapped. Catecholamines 131-144 hydroxyacid oxidase 1 Homo sapiens 159-174 21036562-3 2011 We report the case of a 2-year-old boy hospitalized in a pediatric oncology unit because of an unusual presentation of scurvy revealed by pain and a significant increase in urinary catecholamine levels, raising fear of a neuroblastoma. Catecholamines 181-194 gulonolactone (L-) oxidase, pseudogene Homo sapiens 119-125 20237834-3 2011 Constitutive phosphorylation of ERK, mRNA expression up-regulation of catecholamine-synthesis enzymes, and increased epinephrine release were detected in MCF-7/Her2 cells. Catecholamines 70-83 erb-b2 receptor tyrosine kinase 2 Homo sapiens 154-164 20237834-6 2011 The data also showed that catecholamine prominently stimulated Her2 mRNA expression and promoter activity. Catecholamines 26-39 erb-b2 receptor tyrosine kinase 2 Homo sapiens 63-67 22216029-1 2011 A PKA consensus phosphorylation site S1928 at the alpha(1)1.2 subunit of the rabbit cardiac L-type channel, Ca(V)1.2, is involved in the regulation of Ca(V)1.2 kinetics and affects catecholamine secretion. Catecholamines 181-194 immunoglobulin lambda variable 2-8 Homo sapiens 108-116 21648315-2 2011 COMT is involved in the breakdown of dopamine and other catecholamines, especially in the frontal cortex; hence the carriers of Met allele, with the lower enzymatic activity, are expected to perform better on particular neuro-cognitive tests. Catecholamines 56-70 catechol-O-methyltransferase Homo sapiens 0-4 21099685-1 2011 PURPOSE OF REVIEW: Renalase is a secreted amine oxidase that is synthesized in the kidney, and that metabolizes circulating catecholamines. Catecholamines 124-138 renalase, FAD-dependent amine oxidase Rattus norvegicus 19-27 21099685-7 2011 Renalase is continually excreted in urine, and is enzymatically active and could modulate catecholamines levels in tubular fluid. Catecholamines 90-104 renalase, FAD-dependent amine oxidase Rattus norvegicus 0-8 21099685-11 2011 SUMMARY: Urinary renalase metabolizes urinary catecholamines, and perhaps regulates dopamine concentration in luminal fluid, and modulate proximal tubular sodium transport. Catecholamines 46-60 renalase, FAD-dependent amine oxidase Rattus norvegicus 17-25 19760428-8 2011 Correlations between serum levels of CgA and catecholamines (adrenaline, noradrenaline and dopamine) were evident for hyperthermia (R = 0.632-0.757, p < 0.05 to <0.01), but there was no significant correlation between CgA and catecholamine levels in CSF. Catecholamines 45-59 chromogranin A Homo sapiens 37-40 19760428-8 2011 Correlations between serum levels of CgA and catecholamines (adrenaline, noradrenaline and dopamine) were evident for hyperthermia (R = 0.632-0.757, p < 0.05 to <0.01), but there was no significant correlation between CgA and catecholamine levels in CSF. Catecholamines 45-58 chromogranin A Homo sapiens 37-40 21553382-2 2011 Gata3 null mutation leads to early lethality around embryonic day (E)11.5, but catecholamine precursor administration can rescue Gata3 null mutants to E16.5. Catecholamines 79-92 GATA binding protein 3 Mus musculus 129-134 22216029-1 2011 A PKA consensus phosphorylation site S1928 at the alpha(1)1.2 subunit of the rabbit cardiac L-type channel, Ca(V)1.2, is involved in the regulation of Ca(V)1.2 kinetics and affects catecholamine secretion. Catecholamines 181-194 immunoglobulin lambda variable 2-8 Homo sapiens 151-159 19760428-1 2011 Chromoganin A (CgA) is widely distributed in the secretory granules of endocrine and neuroendocrine cells and cosecreted with hormones such as catecholamines. Catecholamines 143-157 chromogranin A Homo sapiens 15-18 21773031-3 2011 Catecholamines suppress insulin secretion to promote glucose sparing for insulin-independent tissues (brain, nerves) over insulin-dependent tissues (skeletal muscle, liver, and adipose). Catecholamines 0-14 LOC105613195 Ovis aries 24-31 21785727-5 2011 Moreover, increased activity of the renin-angiotensin and sympathetic nervous systems leading to downregulation of receptors may be responsible for the blunted vascular sensitivity to angiotensin II and catecholamines, respectively. Catecholamines 203-217 renin Rattus norvegicus 36-41 20407462-1 2011 The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Catecholamines 4-17 dopa decarboxylase Rattus norvegicus 105-131 20407462-1 2011 The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Catecholamines 4-17 dopa decarboxylase Rattus norvegicus 133-137 21603275-5 2011 The thermogenic effects of catecholamines in obesity are mainly mediated via the beta2, and beta3-adrenergic receptors in humans. Catecholamines 27-41 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 81-86 21773031-3 2011 Catecholamines suppress insulin secretion to promote glucose sparing for insulin-independent tissues (brain, nerves) over insulin-dependent tissues (skeletal muscle, liver, and adipose). Catecholamines 0-14 LOC105613195 Ovis aries 73-80 21773031-3 2011 Catecholamines suppress insulin secretion to promote glucose sparing for insulin-independent tissues (brain, nerves) over insulin-dependent tissues (skeletal muscle, liver, and adipose). Catecholamines 0-14 LOC105613195 Ovis aries 73-80 20945960-0 2011 Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms. Catecholamines 37-50 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 20937285-5 2011 CaMKII inhibition with KN-93 completely prevented catecholamine-induced sustained ventricular tachyarrhythmia in RyR2(R4496C+/-) mice, while the inactive congener KN-92 had no effect. Catecholamines 50-63 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 0-6 20937285-5 2011 CaMKII inhibition with KN-93 completely prevented catecholamine-induced sustained ventricular tachyarrhythmia in RyR2(R4496C+/-) mice, while the inactive congener KN-92 had no effect. Catecholamines 50-63 ryanodine receptor 2, cardiac Mus musculus 113-117 20937285-10 2011 Mechanistically, CAMKII inhibition acts on several elements of the EC coupling cascade, including an attenuation of SR Ca(2+) leak and blunting catecholamine-mediated SERCA activation. Catecholamines 144-157 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 17-23 20945960-8 2011 The inhibitory effect of AICAR and adiponectin on lipolysis was reversed by Compound C. Our results suggest, that adiponectin in physiological concentrations inhibits spontaneous as well as catecholamine-induced lipolysis. Catecholamines 190-203 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 25-30 20945960-8 2011 The inhibitory effect of AICAR and adiponectin on lipolysis was reversed by Compound C. Our results suggest, that adiponectin in physiological concentrations inhibits spontaneous as well as catecholamine-induced lipolysis. Catecholamines 190-203 adiponectin, C1Q and collagen domain containing Homo sapiens 35-46 20945960-8 2011 The inhibitory effect of AICAR and adiponectin on lipolysis was reversed by Compound C. Our results suggest, that adiponectin in physiological concentrations inhibits spontaneous as well as catecholamine-induced lipolysis. Catecholamines 190-203 adiponectin, C1Q and collagen domain containing Homo sapiens 114-125 21051559-5 2011 Patients with tumours due to multiple endocrine neoplasia type 2 and neurofibromatosis type 1 (NF1) showed similar catecholamine metabolite and secretory profiles to patients with adrenaline-producing tumours and no evident hereditary background. Catecholamines 115-128 neurofibromin 1 Homo sapiens 69-93 21777029-3 2011 Here we investigated the expression of mRNAs for catecholamine biosynthetic enzymes tyrosine-hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyl-transferase, and for beta(1)- and beta(2)-adrenoceptors in the right and left ventricles of rats exposed to chronic unpredictable mild stress. Catecholamines 49-62 dopamine beta-hydroxylase Rattus norvegicus 106-131 21957454-7 2011 Additional labeling with c-Fos was seen in the subnucleus interpolaris of the spinal trigeminal nucleus, the rostral ventrolateral medulla, the superior salivatory nucleus, the rostral ventromedial medulla, and the A1, A5, A7 and subcoeruleus catecholamine areas. Catecholamines 243-256 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 25-30 21738729-1 2011 BACKGROUND: Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored lipids, thus mobilizing fatty acids. Catecholamines 125-138 lipase, hormone sensitive Mus musculus 12-36 21738729-1 2011 BACKGROUND: Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored lipids, thus mobilizing fatty acids. Catecholamines 125-138 lipase, hormone sensitive Mus musculus 38-41 20606488-2 2011 We have previously demonstrated that glucocorticoids (GCs) and catecholamines can influence immunomodulation including changes in Th1/Th2 cytokine production. Catecholamines 63-77 negative elongation factor complex member C/D Homo sapiens 130-133 21245980-9 2010 Exposure of PC12 cells to BDNF induced the release of catecholamine. Catecholamines 54-67 brain-derived neurotrophic factor Rattus norvegicus 26-30 21245980-11 2010 Thus, BDNF-TrkB interactions may modulate catecholamine release from adrenal chromaffin cells under acute stress conditions. Catecholamines 42-55 brain-derived neurotrophic factor Rattus norvegicus 6-10 21245980-11 2010 Thus, BDNF-TrkB interactions may modulate catecholamine release from adrenal chromaffin cells under acute stress conditions. Catecholamines 42-55 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 11-15 21051559-5 2011 Patients with tumours due to multiple endocrine neoplasia type 2 and neurofibromatosis type 1 (NF1) showed similar catecholamine metabolite and secretory profiles to patients with adrenaline-producing tumours and no evident hereditary background. Catecholamines 115-128 neurofibromin 1 Homo sapiens 95-98 20937667-1 2010 BACKGROUND: (6R)-5,6,7,8-Tetrahydro-l-biopterin (BH4) is a cofactor for enzymes involved in catecholamine and nitric oxide generation whose synthesis is initiated by GTP cyclohydrolase I (GTPCH-1), encoded by GCH1. Catecholamines 92-105 GTP cyclohydrolase 1 Homo sapiens 166-186 21164481-0 2010 CRTC3 links catecholamine signalling to energy balance. Catecholamines 12-25 CREB regulated transcription coactivator 3 Homo sapiens 0-5 21164481-3 2010 Although the mechanism is unclear, catecholamine signalling is thought to be disrupted in obesity, leading to the development of insulin resistance. Catecholamines 35-48 insulin Homo sapiens 129-136 21164481-5 2010 Crtc3 was activated in response to catecholamine signals, when it reduced adenyl cyclase activity by upregulating the expression of Rgs2, a GTPase-activating protein that also inhibits adenyl cyclase activity. Catecholamines 35-48 CREB regulated transcription coactivator 3 Homo sapiens 0-5 21164481-5 2010 Crtc3 was activated in response to catecholamine signals, when it reduced adenyl cyclase activity by upregulating the expression of Rgs2, a GTPase-activating protein that also inhibits adenyl cyclase activity. Catecholamines 35-48 regulator of G protein signaling 2 Homo sapiens 132-136 20965158-1 2010 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamine but its transcriptional regulation is not fully understood. Catecholamines 77-90 tyrosine hydroxylase Rattus norvegicus 0-20 20965158-1 2010 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamine but its transcriptional regulation is not fully understood. Catecholamines 77-90 tyrosine hydroxylase Rattus norvegicus 22-24 20921225-1 2010 Ca(2+)-dependent activator protein for secretion (CAPS) regulates exocytosis of catecholamine- or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites, such as nerve terminals. Catecholamines 80-93 calcyphosine Homo sapiens 50-54 20926765-2 2010 One such regulatory peptide, catestatin [Cts, human chromogranin A-(352-372)], noncompetitively inhibits nicotinic-cholinergic-stimulated catecholamine release. Catecholamines 138-151 chromogranin A Homo sapiens 29-39 20926765-2 2010 One such regulatory peptide, catestatin [Cts, human chromogranin A-(352-372)], noncompetitively inhibits nicotinic-cholinergic-stimulated catecholamine release. Catecholamines 138-151 chromogranin A Homo sapiens 52-66 20937667-1 2010 BACKGROUND: (6R)-5,6,7,8-Tetrahydro-l-biopterin (BH4) is a cofactor for enzymes involved in catecholamine and nitric oxide generation whose synthesis is initiated by GTP cyclohydrolase I (GTPCH-1), encoded by GCH1. Catecholamines 92-105 GTP cyclohydrolase 1 Homo sapiens 188-195 20937667-1 2010 BACKGROUND: (6R)-5,6,7,8-Tetrahydro-l-biopterin (BH4) is a cofactor for enzymes involved in catecholamine and nitric oxide generation whose synthesis is initiated by GTP cyclohydrolase I (GTPCH-1), encoded by GCH1. Catecholamines 92-105 GTP cyclohydrolase 1 Homo sapiens 209-213 21221199-3 2010 Also, functionally, the relaxant response of human detrusor to catecholamines is mainly mediated through the beta3-ARs. Catecholamines 63-77 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 109-114 21099118-2 2010 Catecholamines bind to beta-adrenergic receptors, causing cAMP generation and activation of PKA, which phosphorylates multiple targets in cardiac muscle, including the cardiac ryanodine receptor/calcium release channel (RyR2) required for muscle contraction. Catecholamines 0-14 ryanodine receptor 2, cardiac Mus musculus 220-224 21099118-4 2010 Here, we found that mice harboring RyR2 channels that cannot be PKA phosphorylated (referred to herein as RyR2-S2808A+/+ mice) exhibited blunted heart rate and cardiac contractile responses to catecholamines (isoproterenol). Catecholamines 193-207 ryanodine receptor 2, cardiac Mus musculus 35-39 21099118-4 2010 Here, we found that mice harboring RyR2 channels that cannot be PKA phosphorylated (referred to herein as RyR2-S2808A+/+ mice) exhibited blunted heart rate and cardiac contractile responses to catecholamines (isoproterenol). Catecholamines 193-207 ryanodine receptor 2, cardiac Mus musculus 106-110 21099118-6 2010 The blunted cardiac response to catecholamines in RyR2-S2808A+/+ mice resulted in impaired exercise capacity. Catecholamines 32-46 ryanodine receptor 2, cardiac Mus musculus 50-54 21099119-2 2010 According to Marks and colleagues, this response is, to a large extent, the consequence of facilitated Ca2+ release from intracellular Ca2+ stores via ryanodine receptor 2 (RyR2), thought to be due to catecholamine-induced increases in RyR2 phosphorylation at serine 2808 (S2808). Catecholamines 201-214 ryanodine receptor 2, cardiac Mus musculus 151-171 21099119-2 2010 According to Marks and colleagues, this response is, to a large extent, the consequence of facilitated Ca2+ release from intracellular Ca2+ stores via ryanodine receptor 2 (RyR2), thought to be due to catecholamine-induced increases in RyR2 phosphorylation at serine 2808 (S2808). Catecholamines 201-214 ryanodine receptor 2, cardiac Mus musculus 173-177 21099119-2 2010 According to Marks and colleagues, this response is, to a large extent, the consequence of facilitated Ca2+ release from intracellular Ca2+ stores via ryanodine receptor 2 (RyR2), thought to be due to catecholamine-induced increases in RyR2 phosphorylation at serine 2808 (S2808). Catecholamines 201-214 ryanodine receptor 2, cardiac Mus musculus 236-240 21099119-3 2010 If catecholamine stimulation is sustained (for example, as occurs in heart failure), RyR2 becomes hyperphosphorylated and "leaky," leading to arrhythmias and other pathology. Catecholamines 3-16 ryanodine receptor 2, cardiac Mus musculus 85-89 20619611-1 2010 RATIONALE: The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 15-43 20619611-1 2010 RATIONALE: The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 45-49 20619611-1 2010 RATIONALE: The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 70-84 catechol-O-methyltransferase Homo sapiens 94-98 20934461-10 2010 Increased pancreastatin plasma levels, correlating with catecholamines levels, have been found in insulin resistance states, such as gestational diabetes or essential hypertension. Catecholamines 56-70 insulin Homo sapiens 98-105 21210927-6 2010 However, the correlations of salivary alpha-amylase with the plasma catecholamines, blood pressure, and heart rate were only partially found to be statistically significant. Catecholamines 68-82 amylase alpha 1A Homo sapiens 29-51 21154325-1 2010 The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 121-135 catechol-O-methyltransferase Homo sapiens 11-39 21154325-1 2010 The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 121-135 catechol-O-methyltransferase Homo sapiens 41-45 19800928-6 2010 Melittin a well-known activator of PLA2 was found to concomitantly promote catecholamine and chromogranin A (CGA) release in a calcium-dependent manner and also to increase AA synthesis in chromaffin cells. Catecholamines 75-88 phospholipase A2 group IB Homo sapiens 35-39 19800928-8 2010 Accordingly addition of exogenous PLA2 stimulated AA synthesis and catecholamine release in permeabilized chromaffin cells, whereas provision of exogenous AA directly increased exocytosis. Catecholamines 67-80 phospholipase A2 group IB Homo sapiens 34-38 20594992-0 2010 The interplay between chromogranin A-derived peptides and cardiac natriuretic peptides in cardioprotection against catecholamine-evoked stress. Catecholamines 115-128 chromogranin A Homo sapiens 22-36 20594992-1 2010 Chromogranin A (CgA) is the major soluble protein co-stored and co-released with catecholamines (CAs) from secretory vesicles in the adrenal medulla chromaffin cells. Catecholamines 81-95 chromogranin A Homo sapiens 0-14 20594992-1 2010 Chromogranin A (CgA) is the major soluble protein co-stored and co-released with catecholamines (CAs) from secretory vesicles in the adrenal medulla chromaffin cells. Catecholamines 81-95 chromogranin A Homo sapiens 16-19 20594992-1 2010 Chromogranin A (CgA) is the major soluble protein co-stored and co-released with catecholamines (CAs) from secretory vesicles in the adrenal medulla chromaffin cells. Catecholamines 97-100 chromogranin A Homo sapiens 0-14 20594992-1 2010 Chromogranin A (CgA) is the major soluble protein co-stored and co-released with catecholamines (CAs) from secretory vesicles in the adrenal medulla chromaffin cells. Catecholamines 97-100 chromogranin A Homo sapiens 16-19 20965217-1 2010 In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA]344-364: RSMRLSFRARGYGFRGPGLQL; human CHGA352-372: SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic-cholinergic-stimulated catecholamine secretion. Catecholamines 224-237 chromogranin A Homo sapiens 40-50 20655339-2 2010 At the human chromogranin A gene locus there are two naturally occurring amino acid substitution variants within the catestatin region, i.e. Gly364Ser and Pro370Leu, displaying differential potencies towards inhibition of nicotinic cholinergic agonist-evoked catecholamine secretion from sympathochromaffin cells and different degrees of processing from the prohormone. Catecholamines 259-272 chromogranin A Homo sapiens 13-27 20655339-2 2010 At the human chromogranin A gene locus there are two naturally occurring amino acid substitution variants within the catestatin region, i.e. Gly364Ser and Pro370Leu, displaying differential potencies towards inhibition of nicotinic cholinergic agonist-evoked catecholamine secretion from sympathochromaffin cells and different degrees of processing from the prohormone. Catecholamines 259-272 chromogranin A Homo sapiens 117-127 20965217-1 2010 In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA]344-364: RSMRLSFRARGYGFRGPGLQL; human CHGA352-372: SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic-cholinergic-stimulated catecholamine secretion. Catecholamines 224-237 cystatin 12, pseudogene Homo sapiens 52-55 20965217-3 2010 Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G364S, P370L, and R374Q that showed differential potencies towards the inhibition of catecholamine secretion. Catecholamines 196-209 chromogranin A Homo sapiens 57-61 20965217-3 2010 Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G364S, P370L, and R374Q that showed differential potencies towards the inhibition of catecholamine secretion. Catecholamines 196-209 cystatin 12, pseudogene Homo sapiens 106-109 20826776-8 2010 Promoter deletion analyses suggested that AP1 transcription factors might mediate catecholamine-stimulated up-regulation of IL8. Catecholamines 82-95 FosB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 42-45 20826776-8 2010 Promoter deletion analyses suggested that AP1 transcription factors might mediate catecholamine-stimulated up-regulation of IL8. Catecholamines 82-95 C-X-C motif chemokine ligand 8 Homo sapiens 124-127 20680617-0 2010 Development of a micro-total analysis system (mu-TAS) for the determination of catecholamines. Catecholamines 79-93 THAS Homo sapiens 49-52 19446349-2 2010 Recently, increased serum CA125 values, in parallel with catecholamines and natriuretic peptides, have also been documented in patients with heart failure. Catecholamines 57-71 mucin 16, cell surface associated Homo sapiens 26-31 20680617-1 2010 In this study, the first micro-total analysis system (mu-TAS) for catecholamines (dopamine, epinephrine, and norepinephrine) analysis in which preconcentration, separation, and determination steps were integrated on a microchip was developed. Catecholamines 66-80 THAS Homo sapiens 57-60 21084859-6 2010 The ability to carry subthreshold Ca (2+) currents and activate BK channels confers to CaV1.3 the unique feature of driving Ca (2+) loading during long interspike intervals and, possibly, to control the Ca (2+) -dependent exocytosis and endocytosis processes that regulate catecholamine secretion and vesicle recycling. Catecholamines 273-286 calcium channel, voltage-dependent, L type, alpha 1D subunit Mus musculus 87-93 20977469-2 2010 Catecholamines induce hypertrophy of vascular smooth muscle through alpha(1) -adrenoceptors, which in cell culture involves the transactivation of epidermal growth factor receptor (EGFR). Catecholamines 0-14 epidermal growth factor receptor Rattus norvegicus 147-179 20977469-2 2010 Catecholamines induce hypertrophy of vascular smooth muscle through alpha(1) -adrenoceptors, which in cell culture involves the transactivation of epidermal growth factor receptor (EGFR). Catecholamines 0-14 epidermal growth factor receptor Rattus norvegicus 181-185 21061160-1 2010 Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Catecholamines 68-81 chromogranin A Homo sapiens 0-14 21061160-1 2010 Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Catecholamines 68-81 chromogranin A Homo sapiens 16-20 21046450-5 2010 Thus, it has been proposed that CgA represents a precursor of biologically active peptides, and a "granulogenic protein" that plays an important role as a chaperone for catecholamine storage in adrenal chromaffin cells. Catecholamines 169-182 chromogranin A Homo sapiens 32-35 21104119-1 2010 The Chromogranin A (CgA)-derived anti-hypertensive peptide catestatin (CST) antagonizes catecholamine secretion, and is a negative myocardial inotrope acting via a nitric oxide-dependent mechanism. Catecholamines 88-101 chromogranin A Rattus norvegicus 4-18 21061166-8 2010 Using an RNA interference rescue strategy in PC12 cells, we were able to demonstrate that RSK2 regulates catecholamine release through the phosphorylation of PLD. Catecholamines 105-118 ribosomal protein S6 kinase A3 Homo sapiens 90-94 21104119-1 2010 The Chromogranin A (CgA)-derived anti-hypertensive peptide catestatin (CST) antagonizes catecholamine secretion, and is a negative myocardial inotrope acting via a nitric oxide-dependent mechanism. Catecholamines 88-101 chromogranin A Rattus norvegicus 20-23 20736996-3 2010 We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence. Catecholamines 85-98 dopamine beta-hydroxylase Rattus norvegicus 48-73 20620233-15 2010 CONCLUSION: Verapamil is highly effective against catecholamine-induced arrhythmia in mice with CASQ2 mutations and may potentiate the antiarrhythmic activity of beta-blockers in humans with CPVT2. Catecholamines 50-63 calsequestrin 2 Mus musculus 96-101 20498605-0 2010 Vasopressin for the treatment of catecholamine-resistant hypotension during a phaeochromocytoma resection in a 6-year-old child. Catecholamines 33-46 arginine vasopressin Homo sapiens 0-11 20952611-1 2010 Catestatin (CST), the 21-amino acid, cationic and hydrophobic peptide proteolytically derived from the ubiquitous chromogranin A (CgA), is an endogenous inhibitor of catecholamine release, a potent vasodilator in vivo and an anti-hypertensive agent in mammals, including humans. Catecholamines 166-179 chromogranin A Homo sapiens 0-10 20952611-1 2010 Catestatin (CST), the 21-amino acid, cationic and hydrophobic peptide proteolytically derived from the ubiquitous chromogranin A (CgA), is an endogenous inhibitor of catecholamine release, a potent vasodilator in vivo and an anti-hypertensive agent in mammals, including humans. Catecholamines 166-179 chromogranin A Homo sapiens 12-15 20952611-1 2010 Catestatin (CST), the 21-amino acid, cationic and hydrophobic peptide proteolytically derived from the ubiquitous chromogranin A (CgA), is an endogenous inhibitor of catecholamine release, a potent vasodilator in vivo and an anti-hypertensive agent in mammals, including humans. Catecholamines 166-179 chromogranin A Homo sapiens 130-133 20736996-3 2010 We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence. Catecholamines 85-98 dopamine beta-hydroxylase Rattus norvegicus 75-78 20859243-11 2010 CONCLUSION: Our study suggests that OCT3 plays a role in the therapeutic action of metformin and that genetic variants of OCT3 may modulate metformin and catecholamine action. Catecholamines 154-167 OCTN3 Homo sapiens 122-126 20739277-1 2010 beta(2)-adrenergic receptors (beta(2)-AR) are low abundance, integral membrane proteins that mediate the effects of catecholamines at the cell surface. Catecholamines 116-130 adrenoceptor beta 2 Homo sapiens 0-28 20739277-1 2010 beta(2)-adrenergic receptors (beta(2)-AR) are low abundance, integral membrane proteins that mediate the effects of catecholamines at the cell surface. Catecholamines 116-130 adrenoceptor beta 2 Homo sapiens 30-40 20678554-5 2010 Intraperitoneal administration of an inhibitor for COX-1, COX-2 or inducible NOS (iNOS), but not for neuronal NOS (nNOS), reduced RS-induced elevation of plasma catecholamine levels and Fos expression in the presympathetic PVN neurons. Catecholamines 161-174 cytochrome c oxidase I, mitochondrial Rattus norvegicus 51-56 20678554-5 2010 Intraperitoneal administration of an inhibitor for COX-1, COX-2 or inducible NOS (iNOS), but not for neuronal NOS (nNOS), reduced RS-induced elevation of plasma catecholamine levels and Fos expression in the presympathetic PVN neurons. Catecholamines 161-174 nitric oxide synthase 2 Rattus norvegicus 67-80 20678554-5 2010 Intraperitoneal administration of an inhibitor for COX-1, COX-2 or inducible NOS (iNOS), but not for neuronal NOS (nNOS), reduced RS-induced elevation of plasma catecholamine levels and Fos expression in the presympathetic PVN neurons. Catecholamines 161-174 nitric oxide synthase 2 Rattus norvegicus 82-86 20498218-11 2010 Experimental increase of cytoplasmic catecholamines by VMAT2 blockade strongly reduced tumour necrosis factor (TNF) independently of canonical extracellular beta-adrenergic signalling. Catecholamines 37-51 tumor necrosis factor Homo sapiens 111-114 20975995-1 2010 BACKGROUND: Renalase is a soluble enzyme that metabolizes circulating catecholamines. Catecholamines 70-84 renalase, FAD dependent amine oxidase Homo sapiens 12-20 20498218-11 2010 Experimental increase of cytoplasmic catecholamines by VMAT2 blockade strongly reduced tumour necrosis factor (TNF) independently of canonical extracellular beta-adrenergic signalling. Catecholamines 37-51 solute carrier family 18 member A2 Homo sapiens 55-60 20981286-4 2010 The thermogenic effects of catecholamines in obesity have been mainly mediated via the beta2- and beta3-adrenergic receptors in humans. Catecholamines 27-41 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 87-92 20939893-0 2010 Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. Catecholamines 0-13 matrix metallopeptidase 7 Homo sapiens 27-32 20939893-0 2010 Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. Catecholamines 0-13 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 58-62 20939893-0 2010 Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer. Catecholamines 0-13 signal transducer and activator of transcription 3 Homo sapiens 67-72 20939893-2 2010 In the present study, we investigated the effects of catecholamine stimulation on MMP-7 expression in gastric cancer cells and elucidated the molecular mechanisms of the up-regulation of MMP-7 level by catecholamine through an adrenergic signaling pathway. Catecholamines 53-66 matrix metallopeptidase 7 Homo sapiens 82-87 20939893-2 2010 In the present study, we investigated the effects of catecholamine stimulation on MMP-7 expression in gastric cancer cells and elucidated the molecular mechanisms of the up-regulation of MMP-7 level by catecholamine through an adrenergic signaling pathway. Catecholamines 202-215 matrix metallopeptidase 7 Homo sapiens 187-192 20498218-11 2010 Experimental increase of cytoplasmic catecholamines by VMAT2 blockade strongly reduced tumour necrosis factor (TNF) independently of canonical extracellular beta-adrenergic signalling. Catecholamines 37-51 tumor necrosis factor Homo sapiens 87-109 20637325-1 2010 Topical effects of a catecholamine on bone morphogenetic protein (BMP)-induced ectopic bone formation were investigated in both in vivo and in vitro experimental systems. Catecholamines 21-34 bone morphogenetic protein 1 Homo sapiens 38-64 20637325-1 2010 Topical effects of a catecholamine on bone morphogenetic protein (BMP)-induced ectopic bone formation were investigated in both in vivo and in vitro experimental systems. Catecholamines 21-34 bone morphogenetic protein 1 Homo sapiens 66-69 20471475-1 2010 PACAP is a critical regulator of long-term catecholamine secretion from the adrenal medulla in vivo, however the receptor or pathways for Ca(2+) entry triggering acute and sustained secretion have not been adequately characterized. Catecholamines 43-56 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 20668031-0 2010 Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity. Catecholamines 53-66 urocortin 2 Mus musculus 0-11 20525643-1 2010 AIMS: Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 73-86 tyrosine hydroxylase Gallus gallus 6-26 20525643-1 2010 AIMS: Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 73-86 tyrosine hydroxylase Gallus gallus 28-30 20668031-2 2010 The peptide urocortin 2 (Ucn 2) inhibits catecholamine synthesis and secretion from adrenal chromaffin cells in vitro and administration to mammals lowers blood pressure (BP). Catecholamines 41-54 urocortin 2 Mus musculus 12-23 20668031-2 2010 The peptide urocortin 2 (Ucn 2) inhibits catecholamine synthesis and secretion from adrenal chromaffin cells in vitro and administration to mammals lowers blood pressure (BP). Catecholamines 41-54 urocortin 2 Mus musculus 25-30 20668031-3 2010 The chromogranin A-null mouse (Chga-/-) manifests systemic hypertension because of excessive catecholamine secretion from the adrenal and decreased catecholamine storage. Catecholamines 93-106 chromogranin A Mus musculus 4-18 20668031-3 2010 The chromogranin A-null mouse (Chga-/-) manifests systemic hypertension because of excessive catecholamine secretion from the adrenal and decreased catecholamine storage. Catecholamines 93-106 chromogranin A Mus musculus 31-35 20668031-3 2010 The chromogranin A-null mouse (Chga-/-) manifests systemic hypertension because of excessive catecholamine secretion from the adrenal and decreased catecholamine storage. Catecholamines 148-161 chromogranin A Mus musculus 4-18 20668031-3 2010 The chromogranin A-null mouse (Chga-/-) manifests systemic hypertension because of excessive catecholamine secretion from the adrenal and decreased catecholamine storage. Catecholamines 148-161 chromogranin A Mus musculus 31-35 20668031-4 2010 In the present study, we investigated whether systemic administration of Ucn 2 could reduce BP and adrenal and plasma levels of catecholamines in vivo. Catecholamines 128-142 urocortin 2 Mus musculus 73-78 20668031-9 2010 In Chga-/- mice only, Ucn 2 decreased adrenal and plasma levels of catecholamines as well as adrenal levels of tyrosine hydroxylase protein and phosphorylation. Catecholamines 67-81 urocortin 2 Mus musculus 22-27 20668031-10 2010 In vitro mechanistic studies demonstrated that Ucn 2 reduces both catecholamine secretion and tyrosine hydroxylase promoter activity, suggesting that the exaggerated action of Ucn 2 to reduce BP in the Chga-/- mouse is mediated through inhibition of both catecholamine synthesis and secretion. Catecholamines 66-79 urocortin 2 Mus musculus 47-52 20668031-10 2010 In vitro mechanistic studies demonstrated that Ucn 2 reduces both catecholamine secretion and tyrosine hydroxylase promoter activity, suggesting that the exaggerated action of Ucn 2 to reduce BP in the Chga-/- mouse is mediated through inhibition of both catecholamine synthesis and secretion. Catecholamines 255-268 urocortin 2 Mus musculus 47-52 20668031-10 2010 In vitro mechanistic studies demonstrated that Ucn 2 reduces both catecholamine secretion and tyrosine hydroxylase promoter activity, suggesting that the exaggerated action of Ucn 2 to reduce BP in the Chga-/- mouse is mediated through inhibition of both catecholamine synthesis and secretion. Catecholamines 255-268 urocortin 2 Mus musculus 176-181 20091127-1 2010 The beta(3)-adrenergic receptor (ADRB3) is predominantly expressed in white and brown adipose tissue and mediates the lipolytic and thermogenic effects of high catecholamine concentrations. Catecholamines 160-173 adrenoceptor beta 3 Bos taurus 4-31 20838244-1 2010 The purpose of this study was to determine whether the increased expression of tyrosine hydroxylase (TH), the first and limiting enzyme in catecholamine synthesis in vasopressin (VP) neurons of the human neonate, represents a primary developmental phenomenon or reflects a secondary phenomenon related to the activation of VP systems due to perinatal hypoxia. Catecholamines 139-152 tyrosine hydroxylase Homo sapiens 79-99 20838244-1 2010 The purpose of this study was to determine whether the increased expression of tyrosine hydroxylase (TH), the first and limiting enzyme in catecholamine synthesis in vasopressin (VP) neurons of the human neonate, represents a primary developmental phenomenon or reflects a secondary phenomenon related to the activation of VP systems due to perinatal hypoxia. Catecholamines 139-152 tyrosine hydroxylase Homo sapiens 101-103 20838244-1 2010 The purpose of this study was to determine whether the increased expression of tyrosine hydroxylase (TH), the first and limiting enzyme in catecholamine synthesis in vasopressin (VP) neurons of the human neonate, represents a primary developmental phenomenon or reflects a secondary phenomenon related to the activation of VP systems due to perinatal hypoxia. Catecholamines 139-152 arginine vasopressin Homo sapiens 166-177 20091127-1 2010 The beta(3)-adrenergic receptor (ADRB3) is predominantly expressed in white and brown adipose tissue and mediates the lipolytic and thermogenic effects of high catecholamine concentrations. Catecholamines 160-173 adrenoceptor beta 3 Bos taurus 33-38 20435076-8 2010 Nesfatin-1/NUCB2 was shown to co-localize in a high percentage of prolactin-releasing peptide producing neurons, in both medullary catecholamine cell groups further supporting its involvement in the stress response. Catecholamines 131-144 nucleobindin 2 Rattus norvegicus 0-10 20935620-1 2010 Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are potent alternative vasoconstrictors in the treatment of septic patients with catecholamine-refractive vasodilatatory shock. Catecholamines 164-177 arginine vasopressin Homo sapiens 9-20 20435076-2 2010 Nesfatin-1/NUCB2-immunoreactive neurons are present in the hypothalamic paraventricular nucleus, the center of the stress-axis, and in the medullary A1 and A2 catecholamine cell groups. Catecholamines 159-172 nucleobindin 2 Rattus norvegicus 0-10 20435076-2 2010 Nesfatin-1/NUCB2-immunoreactive neurons are present in the hypothalamic paraventricular nucleus, the center of the stress-axis, and in the medullary A1 and A2 catecholamine cell groups. Catecholamines 159-172 nucleobindin 2 Rattus norvegicus 11-16 20435076-8 2010 Nesfatin-1/NUCB2 was shown to co-localize in a high percentage of prolactin-releasing peptide producing neurons, in both medullary catecholamine cell groups further supporting its involvement in the stress response. Catecholamines 131-144 nucleobindin 2 Rattus norvegicus 11-16 20471676-5 2010 The mechanisms involved in the vasodilation induced by h HK-1 were similar to that of r/m HK-1 while the mechanisms for coronary vasoconstriction were mediated through the activation of tachykinin NK2 receptors on coronary sympathetic neurons to release catecholamines. Catecholamines 254-268 tachykinin receptor 2 Homo sapiens 197-200 20874043-5 2010 Various studies have suggested that exogenous administration of arginine vasopressin may be an effective adjunctive therapy to traditional catecholamines for the management of hypotension during septic shock. Catecholamines 139-153 arginine vasopressin Homo sapiens 73-84 20679729-0 2010 Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. Catecholamines 10-23 transient receptor potential cation channel, subfamily M, member 4 Mus musculus 65-70 20587416-1 2010 The beta(1)-adrenergic receptor (beta(1)AR) is the predominant betaAR in the heart, mediating the catecholamine-stimulated increase in cardiac rate and force of contraction. Catecholamines 98-111 adrenoceptor beta 1 Homo sapiens 4-42 20122740-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 12-40 20122740-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 42-46 20122740-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Catecholamines 60-74 catechol-O-methyltransferase Homo sapiens 104-108 20506562-0 2010 Role of annexin A6 isoforms in catecholamine secretion by PC12 cells: distinct influence on calcium response. Catecholamines 31-44 annexin A6 Rattus norvegicus 8-18 20506562-6 2010 In this report the effect of annexin A6 (AnxA6) isoforms 1 and 2 on catecholamine secretion has been described. Catecholamines 68-81 annexin A6 Rattus norvegicus 29-39 20506562-6 2010 In this report the effect of annexin A6 (AnxA6) isoforms 1 and 2 on catecholamine secretion has been described. Catecholamines 68-81 annexin A6 Rattus norvegicus 41-46 20679729-9 2010 Strikingly, plasma epinephrine concentration as well as urinary excretion of catecholamine metabolites were substantially elevated in Trpm4-/- mice. Catecholamines 77-90 transient receptor potential cation channel, subfamily M, member 4 Mus musculus 134-139 20679729-11 2010 We therefore conclude that TRPM4 proteins limit catecholamine release from chromaffin cells and that this contributes to increased sympathetic tone and hypertension. Catecholamines 48-61 transient receptor potential cation channel, subfamily M, member 4 Mus musculus 27-32 21072351-2 2010 As a cofactor of dopamine-beta-hydroxylase, peptidyl-alpha-monooxygenase, superoxide dismutases, and many other enzymes, copper is a critical contributor to catecholamine biosynthesis, activation of neuropeptides and hormones, protection against reactive oxygen species, respiration and other processes essential for normal CNS function. Catecholamines 157-170 dopamine beta-hydroxylase Homo sapiens 17-42 20727442-1 2010 Intravenous vasopressin at 0.01 to 0.04 units/kg/h increased median mean blood pressure from 26 mm Hg (range 18-44) to 41 mm Hg (range 17-90) by 12 hours of infusion (P=.002) and allowed weaning of catecholamines in a group of extremely low birth weight infants with refractory hypotension. Catecholamines 198-212 arginine vasopressin Homo sapiens 12-23 20664070-7 2010 In IH-treated rats, nAChR mRNAs were downregulated in AMC, which resulted in a markedly attenuated nicotine-evoked elevation in [Ca(2+)](i) and subsequent catecholamine secretion. Catecholamines 155-168 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 20-25 20493917-1 2010 The regulation of tyrosine hydroxylase (TH, the rate limiting enzyme involved in catecholamine synthesis) is critical for the acute and sustained release of catecholamines from adrenal medullary chromaffin cells, however the mechanisms involved have only ever been investigated under in vitro/in situ conditions. Catecholamines 81-94 tyrosine hydroxylase Rattus norvegicus 18-38 20493917-1 2010 The regulation of tyrosine hydroxylase (TH, the rate limiting enzyme involved in catecholamine synthesis) is critical for the acute and sustained release of catecholamines from adrenal medullary chromaffin cells, however the mechanisms involved have only ever been investigated under in vitro/in situ conditions. Catecholamines 157-171 tyrosine hydroxylase Rattus norvegicus 18-38 20495143-11 2010 Our results suggest that catecholamines induce myocyte necrosis primarily through beta(1)-AR-mediated increases in I(Ca-L), but other mechanisms are also involved in rodents. Catecholamines 25-39 adrenergic receptor, beta 1 Mus musculus 82-92 20702699-6 2010 In contrast, the amperometric current that precedes the spike remained unchanged, indicating that synaptophysin/dynamin association does not regulate the initial fusion pore, but it appears to target a later step of exocytosis to control the amount of catecholamines released during a single vesicle fusion event. Catecholamines 252-266 synaptophysin Homo sapiens 98-111 20718822-7 2010 When hearts are subjected to catecholamine stress, PLM minimizes the risks of arrhythmogenesis by reducing Na(+) overload and simultaneously preserves inotropy by inhibiting Na(+)/Ca(2+) exchanger. Catecholamines 29-42 FXYD domain containing ion transport regulator 1 Homo sapiens 51-54 21073414-0 2010 Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: achievements and unsolved problems. Catecholamines 74-88 renalase, FAD dependent amine oxidase Homo sapiens 0-8 21073414-1 2010 Renalase is a recently discovered secretory enzyme responsible for selective degradation of blood catecholamines. Catecholamines 98-112 renalase, FAD dependent amine oxidase Homo sapiens 0-8 20718822-7 2010 When hearts are subjected to catecholamine stress, PLM minimizes the risks of arrhythmogenesis by reducing Na(+) overload and simultaneously preserves inotropy by inhibiting Na(+)/Ca(2+) exchanger. Catecholamines 29-42 solute carrier family 8 member A1 Homo sapiens 174-196 20484225-4 2010 We identified a heterozygous germline SDHA mutation, p.Arg589Trp, in a woman suffering from catecholamine-secreting abdominal paraganglioma. Catecholamines 92-105 succinate dehydrogenase complex flavoprotein subunit A Homo sapiens 38-42 20827341-2 2010 It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medulla. Catecholamines 71-84 tyrosine hydroxylase Rattus norvegicus 114-134 20231847-2 2010 GPR74 also inhibits catecholamine-induced adipocyte lipolysis and regulates fat mass in humans. Catecholamines 20-33 neuropeptide FF receptor 2 Homo sapiens 0-5 20827341-2 2010 It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medulla. Catecholamines 71-84 tyrosine hydroxylase Rattus norvegicus 136-138 20827341-2 2010 It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medulla. Catecholamines 71-84 dopamine beta-hydroxylase Rattus norvegicus 144-169 20827341-2 2010 It is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medulla. Catecholamines 71-84 dopamine beta-hydroxylase Rattus norvegicus 171-174 20827341-6 2010 Nicotine as a ligand of the nicotinic acetylcholine receptor (nAChR) in adrenal medulla stimulates catecholamine secretion and activates TH and DBH gene expression. Catecholamines 99-112 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 28-60 20827341-6 2010 Nicotine as a ligand of the nicotinic acetylcholine receptor (nAChR) in adrenal medulla stimulates catecholamine secretion and activates TH and DBH gene expression. Catecholamines 99-112 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 62-67 20570658-1 2010 The aim of this study is to determine the efficacy of injecting adult bone marrow derived stem cells (BMSCs) transfected with a pEGFP-C2 plasmid containing the gene for Tyrosine Hydroxylase (TH) into the lateral ventricle for treating rats with Parkinson"s Disease (PD) induced by injections into the Substantia Nigra pars compacta (SNc) with 6-hydroxydopamine (6-OHDA), a potent and selective neurotoxin for catecholamine expressing neurons. Catecholamines 409-422 tyrosine hydroxylase Rattus norvegicus 169-189 20626912-2 2010 Arachidonate 12-lipoxygenase (ALOX12), an important enzyme, metabolizes AA to 12-HPETE, which affects catecholamine synthesis. Catecholamines 102-115 arachidonate 12-lipoxygenase, 12S type Homo sapiens 0-28 20626912-2 2010 Arachidonate 12-lipoxygenase (ALOX12), an important enzyme, metabolizes AA to 12-HPETE, which affects catecholamine synthesis. Catecholamines 102-115 arachidonate 12-lipoxygenase, 12S type Homo sapiens 30-36 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 46-59 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 20653572-14 2010 Catecholamines increased the most in the heavy bag group and the sprint group and increased to a lesser degree in the TASER, OC, and K-9 groups. Catecholamines 0-14 keratin 9 Canis lupus familiaris 133-136 20463049-0 2010 Hindbrain catecholamine neurons modulate the growth hormone but not the feeding response to ghrelin. Catecholamines 10-23 growth hormone 1 Homo sapiens 45-59 20463049-9 2010 The similar pattern of Fos expression in catecholamine cell groups after GH and ghrelin and the prolonged GH secretion in response to ghrelin in DSAP rats together suggest that activation of hindbrain catecholamine neurons by ghrelin or GH could be a component of a negative feedback response controlling GH levels. Catecholamines 41-54 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-26 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 46-59 phenylethanolamine-N-methyltransferase Rattus norvegicus 143-147 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 85-98 vesicle-associated membrane protein 1 Rattus norvegicus 78-83 20458002-11 2010 Expression of the AT(1A)R predominantly in C1 catecholamine neurons restores the response to Ang II in the AT(1A)(-/-) mouse and demonstrates that these neurons are sympathoexcitatory in the mouse. Catecholamines 46-59 angiotensin II receptor, type 1a Mus musculus 18-23 20458002-11 2010 Expression of the AT(1A)R predominantly in C1 catecholamine neurons restores the response to Ang II in the AT(1A)(-/-) mouse and demonstrates that these neurons are sympathoexcitatory in the mouse. Catecholamines 46-59 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 93-99 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 85-98 dopamine beta-hydroxylase Rattus norvegicus 135-138 20378607-4 2010 We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. Catecholamines 85-98 phenylethanolamine-N-methyltransferase Rattus norvegicus 143-147 20378607-5 2010 We also detected trans-regulated expression of Vmat1 and Chga (both involved in catecholamine storage), with co-localization of these trans-eQTLs to the Pnmt locus. Catecholamines 80-93 solute carrier family 18 member A1 Rattus norvegicus 47-52 20378607-5 2010 We also detected trans-regulated expression of Vmat1 and Chga (both involved in catecholamine storage), with co-localization of these trans-eQTLs to the Pnmt locus. Catecholamines 80-93 chromogranin A Rattus norvegicus 57-61 20556885-7 2010 CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice. Catecholamines 107-120 cystathionase (cystathionine gamma-lyase) Mus musculus 0-3 20143408-1 2010 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines released by oxygen-sensitive cells in response to hypoxic conditions. Catecholamines 77-91 tyrosine hydroxylase Rattus norvegicus 0-20 20143408-1 2010 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines released by oxygen-sensitive cells in response to hypoxic conditions. Catecholamines 77-91 tyrosine hydroxylase Rattus norvegicus 22-24 20044210-4 2010 Catecholamines and cortisol in plasma and lipopolysaccharide (LPS) stimulated levels of TNF-alpha and IL-6 by peripheral leucocytes were assessed along with severity of obsessive-compulsive symptoms, disgust, and anxiety levels using Visual Analogue Scales prior, during and after a provocation paradigm. Catecholamines 0-14 tumor necrosis factor Homo sapiens 88-97 20044210-4 2010 Catecholamines and cortisol in plasma and lipopolysaccharide (LPS) stimulated levels of TNF-alpha and IL-6 by peripheral leucocytes were assessed along with severity of obsessive-compulsive symptoms, disgust, and anxiety levels using Visual Analogue Scales prior, during and after a provocation paradigm. Catecholamines 0-14 interleukin 6 Homo sapiens 102-106 22371762-1 2010 Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 112-140 22371762-1 2010 Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 142-146 20116404-1 2010 In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA](344-364): RSMRLSFRARGYGFRGPGLQL; human CHGA(352-372): SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic-cholinergic-stimulated catecholamine secretion. Catecholamines 228-241 chromogranin A Homo sapiens 40-50 20116404-1 2010 In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA](344-364): RSMRLSFRARGYGFRGPGLQL; human CHGA(352-372): SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic-cholinergic-stimulated catecholamine secretion. Catecholamines 228-241 cystatin 12, pseudogene Homo sapiens 52-55 20116404-3 2010 Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G(364)S, P(370)L, and R(374)Q that showed differential potencies towards the inhibition of catecholamine secretion. Catecholamines 202-215 chromogranin A Homo sapiens 57-61 20116404-3 2010 Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G(364)S, P(370)L, and R(374)Q that showed differential potencies towards the inhibition of catecholamine secretion. Catecholamines 202-215 cystatin 12, pseudogene Homo sapiens 106-109 20356833-2 2010 a-Syn binding inhibits the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 94-107 joined toes Mus musculus 2-5 20356833-7 2010 In dopaminergic tissues from mice overexpressing human a-Syn in catecholamine neurons only, TH-Ser-19 and TH-Ser-40 phosphorylation and activity were also reduced, whereas PP2A was more active. Catecholamines 64-77 synuclein, alpha Mus musculus 55-60 20573904-8 2010 Finally, central injection of NMDA induces c-Fos expression in catecholamine- and nitric oxide-producing neurons in the hypothalamus of mutant mice, indicating a possible kisspeptin-independent GnRH/LH release by NMDA through activation of these neurons. Catecholamines 63-76 FBJ osteosarcoma oncogene Mus musculus 43-48 20437524-8 2010 The data demonstrate that Phox2a is present in all brainstem catecholamine neurons, in circumscribed populations of NADPH(+) neurons, and in a subset of neurons that influences sympathetic and parasympathetic outflow. Catecholamines 61-74 paired-like homeobox 2a Rattus norvegicus 26-32 20437524-10 2010 Considered with data demonstrating that Phox2a is part of the transcriptional complex that drives expression of dopamine-beta-hydroxylase and can also up-regulate expression of other genes, the data support the conclusion that Phox2a plays an important role in brainstem catecholamine neurotransmission and in the regulation of adaptive homeostatic functions in the adult nervous system. Catecholamines 271-284 paired-like homeobox 2a Rattus norvegicus 40-46 20437524-10 2010 Considered with data demonstrating that Phox2a is part of the transcriptional complex that drives expression of dopamine-beta-hydroxylase and can also up-regulate expression of other genes, the data support the conclusion that Phox2a plays an important role in brainstem catecholamine neurotransmission and in the regulation of adaptive homeostatic functions in the adult nervous system. Catecholamines 271-284 dopamine beta-hydroxylase Rattus norvegicus 112-137 20437524-10 2010 Considered with data demonstrating that Phox2a is part of the transcriptional complex that drives expression of dopamine-beta-hydroxylase and can also up-regulate expression of other genes, the data support the conclusion that Phox2a plays an important role in brainstem catecholamine neurotransmission and in the regulation of adaptive homeostatic functions in the adult nervous system. Catecholamines 271-284 paired-like homeobox 2a Rattus norvegicus 227-233 20556885-7 2010 CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice. Catecholamines 107-120 cystathionase (cystathionine gamma-lyase) Mus musculus 156-159 20556885-7 2010 CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice. Catecholamines 107-120 cystathionase (cystathionine gamma-lyase) Mus musculus 156-159 20340066-3 2010 We have shown that neonatal hyperleptinemia on lactation programs for leptin resistance, hyperthyroidism, and higher corticosterone and catecholamines levels with cardiovascular consequences. Catecholamines 136-150 leptin Rattus norvegicus 33-39 19912274-7 2010 Given the striking similarities between the enzymatic steps in the morphine biosynthetic pathway and those driving the evolutionary adaptation of catecholamine chemical species to accommodate an expansion of interactive but distinct signaling systems, it is our overall contention that the evolutionary emergence of catecholamine systems required conservation and selective "retrofit" of specific enzyme activities, that is, COMT, drawn from cellular morphine expression. Catecholamines 316-329 catechol-O-methyltransferase Homo sapiens 425-429 20385503-3 2010 However, data from animal and clinical studies have suggested that catecholamines can induce insulin resistance. Catecholamines 67-81 insulin Homo sapiens 93-100 20385503-4 2010 More recent trials support the hypothesis that catecholamines inhibit adiponectin secretion. Catecholamines 47-61 adiponectin, C1Q and collagen domain containing Homo sapiens 70-81 20206166-3 2010 Acute hypoxia results in internalization of NK(1) receptors, suggesting that CIH also may affect the subcellular distribution of NK(1) receptors in subpopulations of cNTS neurons, some of which may express tyrosine hydroxylase, the rate-limiting enzyme for catecholamine synthesis (TH). Catecholamines 257-270 tachykinin 1 Mus musculus 44-49 20646388-6 2010 The intraoperative parathyroid hormone (PTH) assay is an essential tool because the stress of orotracheal intubation elicits the raising of the catecholamine levels, and the catecholamines stimulates PTH secretion. Catecholamines 144-157 parathyroid hormone Homo sapiens 19-38 20646388-6 2010 The intraoperative parathyroid hormone (PTH) assay is an essential tool because the stress of orotracheal intubation elicits the raising of the catecholamine levels, and the catecholamines stimulates PTH secretion. Catecholamines 144-157 parathyroid hormone Homo sapiens 40-43 20646388-6 2010 The intraoperative parathyroid hormone (PTH) assay is an essential tool because the stress of orotracheal intubation elicits the raising of the catecholamine levels, and the catecholamines stimulates PTH secretion. Catecholamines 174-188 parathyroid hormone Homo sapiens 19-38 20646388-6 2010 The intraoperative parathyroid hormone (PTH) assay is an essential tool because the stress of orotracheal intubation elicits the raising of the catecholamine levels, and the catecholamines stimulates PTH secretion. Catecholamines 174-188 parathyroid hormone Homo sapiens 40-43 20646388-6 2010 The intraoperative parathyroid hormone (PTH) assay is an essential tool because the stress of orotracheal intubation elicits the raising of the catecholamine levels, and the catecholamines stimulates PTH secretion. Catecholamines 174-188 parathyroid hormone Homo sapiens 200-203 20103720-1 2010 Catestatin is a natural peptide of higher organisms including humans, with a wide variety of biological functions involved in catecholamine inhibition, cardiovascular regulation, control of blood pressure, inflammation, and innate immunity. Catecholamines 126-139 chromogranin A Homo sapiens 0-10 20882755-1 2010 In this study, the effect of pharmacological inhibition of catecholaminergic activity on hCG-induced spawning was evaluated and correlated with tyrosine hydroxylase (TH) activity, the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 59-72 chorionic gonadotropin subunit beta 5 Homo sapiens 89-92 20882755-11 2010 The results indicate the involvement of catecholamines during the hCG-induced spawning and the specific functional nature of the involvement needs further investigation. Catecholamines 40-54 chorionic gonadotropin subunit beta 5 Homo sapiens 66-69 20184889-2 2010 While beta 3-AR"s role in the cardiovascular system remains controversial, increasing evidence suggests that it serves as a "brake" in sympathetic overstimulation - it is activated at high catecholamine concentrations, producing a negative inotropic effect that antagonizes beta1- and beta2-AR activity. Catecholamines 189-202 adrenoceptor beta 3 Homo sapiens 6-15 19793209-14 2010 CONCLUSIONS: Low-dose AVP therapy should be considered as rescue therapy when high-dose catecholamine therapy and/or steroid administration do not produce sufficient increase in the blood pressure. Catecholamines 88-101 arginine vasopressin Homo sapiens 22-25 20490692-5 2010 Genetic knockout of MAO A, one of the key enzymes in catecholamine and serotonin metabolism in the brain, weakened the startle reaction and TST-induced hyperthermia but had no significant effect on the immobility of Tg8 mice, which provides evidence of differences in the neurochemical regulation of these reactions. Catecholamines 53-66 monoamine oxidase A Mus musculus 20-25 20468011-2 2010 The method is based on the reaction of diazotized 4-aminoantipyrine (4-AAP) with catecholamines in a basic medium (pH = 10-11) to yield pink-coloured products having absorption maxima at 500, 505 and 480 nm for DO.HCl, VMA and DOB.HCl, respectively. Catecholamines 81-95 serpin family F member 2 Homo sapiens 71-74 20100649-3 2010 Previous reports from our laboratory have described a 40 kDa catecholamine regulated heat shock-like protein (CRP40), an alternate gene product of the 70 kDa mitochondrial heat shock protein, mortalin. Catecholamines 61-74 heat shock protein family A (Hsp70) member 9 Homo sapiens 110-115 20100649-9 2010 Thus, the data suggest that human CRP40/mortalin is modulated by dopaminergic activity and may act to protect neurons from excess catecholamine activity in regions of the brain associated with psychosis. Catecholamines 130-143 heat shock protein family A (Hsp70) member 9 Homo sapiens 34-39 20351116-3 2010 We also showed that adrenal GRK2 inhibition decreases circulating CAs and improves cardiac inotropic reserve and function. Catecholamines 66-69 G protein-coupled receptor kinase 2 Mus musculus 28-32 20351116-9 2010 Thus, adrenal-targeted GRK2 gene KO decreases circulating CAs, leading to improved cardiac function and beta-adrenergic reserve in post-MI HF. Catecholamines 58-61 G protein-coupled receptor kinase 2 Mus musculus 23-27 19998492-5 2010 Using real type PCR, we found a reduction of the tyrosine hydroxylase (Th) mRNA level, the rate-limiting enzyme in catecholamine synthesis, in the whole pons of P15 (-36%), P30 (-47%) and P50 (-42%) Mecp2 null male as well as in adult heterozygous female (-44%) mice. Catecholamines 115-128 cyclin dependent kinase inhibitor 2B Mus musculus 161-164 20144588-3 2010 We performed a series of experiments in beta3-null mice to determine the role of the beta3 subunit in catecholamine release from the adrenal chromaffin system. Catecholamines 102-115 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 85-90 20176067-0 2010 Reserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles. Catecholamines 76-89 solute carrier family 6 member 2 Rattus norvegicus 31-57 20144588-8 2010 In conclusion, our results indicate the importance of the beta3 subunit in determining calcium channel characteristics and catecholamine release in adrenal chromaffin cells. Catecholamines 123-136 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 58-63 20359597-1 2010 OBJECTIVES: The purpose of this study is to understand whether naturally occurring genetic variation in the promoter of chromogranin B (CHGB), a major constituent of catecholamine storage vesicles, is functional and confers risk for cardiovascular disease. Catecholamines 166-179 chromogranin B Homo sapiens 120-134 20184923-10 2010 Increased pancreastatin plasma levels, correlating with catecholamines levels, have been found in insulin resistance states, such as gestational diabetes or essential hypertension. Catecholamines 56-70 insulin Homo sapiens 98-105 20359597-1 2010 OBJECTIVES: The purpose of this study is to understand whether naturally occurring genetic variation in the promoter of chromogranin B (CHGB), a major constituent of catecholamine storage vesicles, is functional and confers risk for cardiovascular disease. Catecholamines 166-179 chromogranin B Homo sapiens 136-140 20359597-2 2010 BACKGROUND: CHGB plays a necessary (catalytic) role in catecholamine storage vesicle biogenesis. Catecholamines 55-68 chromogranin B Homo sapiens 12-16 20124442-1 2010 BACKGROUND: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 69-82 tyrosine hydroxylase Homo sapiens 12-32 19923365-6 2010 Furthermore, increased AT(2)R expression and the presence of hypoxia and oxidative stress may, in turn, explain the higher adrenal mRNA levels of enzymes involved in catecholamine synthesis. Catecholamines 166-179 angiotensin II receptor, type 2 Rattus norvegicus 23-29 20124442-1 2010 BACKGROUND: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 69-82 tyrosine hydroxylase Homo sapiens 34-36 20139771-10 2010 The human CHGA tertiles also differed in epinephrine secretion as well as degree of CHGA processing to catestatin (catecholamine release-inhibitory peptide derived from CHGA processing). Catecholamines 115-128 chromogranin A Homo sapiens 10-14 20139771-10 2010 The human CHGA tertiles also differed in epinephrine secretion as well as degree of CHGA processing to catestatin (catecholamine release-inhibitory peptide derived from CHGA processing). Catecholamines 115-128 chromogranin A Homo sapiens 103-113 20139771-11 2010 CONCLUSION: Thus, across mammalian species, an optimal amount of CHGA may be required to establish appropriate catecholamine storage and release, and hence BP homeostasis. Catecholamines 111-124 chromogranin A Homo sapiens 65-69 19958792-3 2010 Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme in the biosynthesis of catecholamines such as dopamine and norepinephrine, which are deeply involved in human mental functions and behaviors. Catecholamines 89-103 tyrosine hydroxylase Homo sapiens 0-20 20145201-11 2010 In summary, our data show a high capacity of myoglobin-deficient mice to adapt to catecholamine induced cardiac stress which is associated with activation of a distinct cardiac gene expression program. Catecholamines 82-95 myoglobin Mus musculus 45-54 20135061-3 2010 Catecholamines, released during ACS, contribute to platelet aggregation through platelet alpha2A-(alpha2A-AR) and beta2-adrenergic receptor (beta2-AR) stimulation. Catecholamines 0-14 adrenoceptor alpha 2A Homo sapiens 98-108 20135061-3 2010 Catecholamines, released during ACS, contribute to platelet aggregation through platelet alpha2A-(alpha2A-AR) and beta2-adrenergic receptor (beta2-AR) stimulation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 114-139 20135061-3 2010 Catecholamines, released during ACS, contribute to platelet aggregation through platelet alpha2A-(alpha2A-AR) and beta2-adrenergic receptor (beta2-AR) stimulation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 141-149 20346182-13 2010 Vasopressin administration (for group A) was associated with a higher 24 hour diuresis) (0.0001).In conclusion, low-dose of infused vasopressin during cardiopulmonary bypass and for the next 4 hours is beneficial for its postoperative hemodynamic profile, reduces the doses of requirements of catecholamines and contributes to prevention of the postcardiotomy vasoplegic shock in the patient with low ejection fraction who is receiving ACE preoperatively. Catecholamines 293-307 arginine vasopressin Homo sapiens 0-11 20346182-13 2010 Vasopressin administration (for group A) was associated with a higher 24 hour diuresis) (0.0001).In conclusion, low-dose of infused vasopressin during cardiopulmonary bypass and for the next 4 hours is beneficial for its postoperative hemodynamic profile, reduces the doses of requirements of catecholamines and contributes to prevention of the postcardiotomy vasoplegic shock in the patient with low ejection fraction who is receiving ACE preoperatively. Catecholamines 293-307 arginine vasopressin Homo sapiens 132-143 19958792-3 2010 Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme in the biosynthesis of catecholamines such as dopamine and norepinephrine, which are deeply involved in human mental functions and behaviors. Catecholamines 89-103 tyrosine hydroxylase Homo sapiens 22-24 19958792-4 2010 It has recently been reported that the C-824T single nucleotide polymorphism in the promoter region of the TH gene (rs10770141) affects promoter activity of the TH gene and urinary catecholamine levels. Catecholamines 181-194 tyrosine hydroxylase Homo sapiens 107-109 20480001-2 2010 Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, can potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. Catecholamines 79-93 tyrosinase Homo sapiens 95-105 20480001-2 2010 Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, can potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. Catecholamines 79-92 tyrosinase Homo sapiens 95-105 20054004-2 2010 Here, we examined the effect of specific Cav1.2 allosteric modulators, BayK 8644 (BayK) and FPL64176 (FPL), on the kinetics of catecholamine release, as monitored by amperometry in single bovine chromaffin cells. Catecholamines 127-140 calcium voltage-gated channel subunit alpha1 C Bos taurus 41-47 20044516-3 2010 METHODS AND RESULTS: We now report the generation and detailed analysis of the corresponding Mlp(W4R/+) and Mlp(W4R/W4R) knock-in animals, which develop an age- and gene dosage-dependent hypertrophic cardiomyopathy and heart failure phenotype, characterized by almost complete loss of contractile reserve under catecholamine induced stress. Catecholamines 311-324 cysteine and glycine rich protein 3 Homo sapiens 108-111 20009010-1 2010 Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. Catecholamines 61-74 chromogranin A Mus musculus 0-14 20009010-1 2010 Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. Catecholamines 61-74 chromogranin A Mus musculus 16-20 20009010-1 2010 Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. Catecholamines 159-172 chromogranin A Mus musculus 0-14 20009010-1 2010 Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. Catecholamines 159-172 chromogranin A Mus musculus 16-20 20234817-5 2010 The structural remodeling of the heart in mice harboring Rb1(-/-):Trp53(-/-) PCCs suggests that the mortality of these mice may be attributable to the inappropriate release of catecholamines from the mutated adrenal chromaffin cells. Catecholamines 176-190 RB transcriptional corepressor 1 Mus musculus 57-60 20234817-5 2010 The structural remodeling of the heart in mice harboring Rb1(-/-):Trp53(-/-) PCCs suggests that the mortality of these mice may be attributable to the inappropriate release of catecholamines from the mutated adrenal chromaffin cells. Catecholamines 176-190 transformation related protein 53 Mus musculus 66-71 19931358-9 2010 Here, abundance of transcripts encoding enzymes required for adrenomedullary catecholamine biosynthesis, namely TH (tyrosine hydroxylase) and PNMT (phenylethanolamine N-methyltransferase), was higher in PACAP+/+ mice after 6 h of unrelieved restraint. Catecholamines 77-90 tyrosine hydroxylase Mus musculus 116-136 19931358-9 2010 Here, abundance of transcripts encoding enzymes required for adrenomedullary catecholamine biosynthesis, namely TH (tyrosine hydroxylase) and PNMT (phenylethanolamine N-methyltransferase), was higher in PACAP+/+ mice after 6 h of unrelieved restraint. Catecholamines 77-90 phenylethanolamine-N-methyltransferase Mus musculus 142-146 19931358-9 2010 Here, abundance of transcripts encoding enzymes required for adrenomedullary catecholamine biosynthesis, namely TH (tyrosine hydroxylase) and PNMT (phenylethanolamine N-methyltransferase), was higher in PACAP+/+ mice after 6 h of unrelieved restraint. Catecholamines 77-90 phenylethanolamine-N-methyltransferase Mus musculus 148-186 19931358-9 2010 Here, abundance of transcripts encoding enzymes required for adrenomedullary catecholamine biosynthesis, namely TH (tyrosine hydroxylase) and PNMT (phenylethanolamine N-methyltransferase), was higher in PACAP+/+ mice after 6 h of unrelieved restraint. Catecholamines 77-90 adenylate cyclase activating polypeptide 1 Mus musculus 203-208 20017209-3 2010 Tyrosine hydroxylase is the entry enzyme into catecholamine biosynthesis and is frequently used as a marker for catecholaminergic neurons. Catecholamines 46-59 tyrosine hydroxylase Danio rerio 0-20 20089903-2 2010 We have recently reported that the absence of chromogranin A (CgA) caused important changes in the accumulation and in the exocytosis of catecholamines (CAs) using a CgA-knock-out (CgA-KO) mouse. Catecholamines 153-156 chromogranin A Mus musculus 46-60 19857486-6 2010 The action of these catecholamines was antagonized by beta(2)-adrenoceptor antagonist, but not by alpha(1)-, alpha(2)- and beta(1)-adrenoceptor antagonist. Catecholamines 20-34 adrenoceptor beta 2 Homo sapiens 54-74 19914944-6 2010 UCN2 on CSNA, hemodynamics, and plasma catecholamines in normal conscious sheep. Catecholamines 39-53 urocortin-2 Ovis aries 0-4 19854260-6 2010 Prior to the observed increase in NT-3 protein levels, the examined catecholamines increased NT-3 mRNA levels with maximal effects observed after 1h (noradrenaline) and 2h (adrenaline and dopamine) of incubation causing 2.4-, 2.6- and 3-fold elevation, respectively. Catecholamines 68-82 neurotrophin 3 Rattus norvegicus 93-97 19946713-1 2010 The catechol-O-methyltransferase gene (COMT) plays a crucial role in the metabolism of catecholamines in the frontal cortex. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 4-32 19946713-1 2010 The catechol-O-methyltransferase gene (COMT) plays a crucial role in the metabolism of catecholamines in the frontal cortex. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 39-43 20089903-0 2010 Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles. Catecholamines 41-54 chromogranin B Mus musculus 0-14 20089903-2 2010 We have recently reported that the absence of chromogranin A (CgA) caused important changes in the accumulation and in the exocytosis of catecholamines (CAs) using a CgA-knock-out (CgA-KO) mouse. Catecholamines 153-156 chromogranin A Mus musculus 62-65 20089903-2 2010 We have recently reported that the absence of chromogranin A (CgA) caused important changes in the accumulation and in the exocytosis of catecholamines (CAs) using a CgA-knock-out (CgA-KO) mouse. Catecholamines 137-151 chromogranin A Mus musculus 46-60 20089903-2 2010 We have recently reported that the absence of chromogranin A (CgA) caused important changes in the accumulation and in the exocytosis of catecholamines (CAs) using a CgA-knock-out (CgA-KO) mouse. Catecholamines 137-151 chromogranin A Mus musculus 62-65 20089903-9 2010 These data indicate that the mechanisms for vesicular accumulation of CAs in the CgB-KO cells were saturated, while there was ample capacity for further accumulation in WT cells. Catecholamines 70-73 chromogranin B Mus musculus 81-84 20933201-7 2010 In the heart, their contractile effects, which are functionally antipathetic to those of beta1/2-AR, may protect the myocardium against adverse effects of excessive catecholamine stimulation and perhaps mediate additional ancillary effects on key aspects of electrophysiology or remodeling. Catecholamines 165-178 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 89-99 20090932-8 2010 In vitro studies revealed that catecholamines inhibit CTLA-4 upregulation in activated T cells. Catecholamines 31-45 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 54-60 20090932-11 2010 The data demonstrate that surviving T cells in stroke patients remain fully functional and are primed towards a TH1 response, in addition we provide evidence that catecholamine mediated inhibition of CTLA-4 expression and serum HMGB1 release are possible mediators in stroke induced activation of T cells. Catecholamines 163-176 negative elongation factor complex member C/D Homo sapiens 112-115 20090932-11 2010 The data demonstrate that surviving T cells in stroke patients remain fully functional and are primed towards a TH1 response, in addition we provide evidence that catecholamine mediated inhibition of CTLA-4 expression and serum HMGB1 release are possible mediators in stroke induced activation of T cells. Catecholamines 163-176 cytotoxic T-lymphocyte associated protein 4 Homo sapiens 200-206 20071512-10 2010 Our data highlight the role of Cav1.3, and to a minor degree of Cav1.2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress. Catecholamines 195-208 calcium channel, voltage-dependent, L type, alpha 1D subunit Mus musculus 31-37 19770745-8 2010 MEASUREMENTS AND MAIN RESULTS: We observed that WT FVB and beta2 adrenergic receptor knockout mice developed systolic dysfunction in response to continuous catecholamine infusion, whereas WT C57 mice developed diastolic dysfunction. Catecholamines 156-169 adrenergic receptor, beta 2 Mus musculus 59-84 20662728-1 2010 Catestatin is a bioactive peptide of chromogranin A (CHGA) that is co-released with catecholamines from secretory vesicles. Catecholamines 84-98 chromogranin A Homo sapiens 0-10 20662728-1 2010 Catestatin is a bioactive peptide of chromogranin A (CHGA) that is co-released with catecholamines from secretory vesicles. Catecholamines 84-98 chromogranin A Homo sapiens 37-51 20662728-1 2010 Catestatin is a bioactive peptide of chromogranin A (CHGA) that is co-released with catecholamines from secretory vesicles. Catecholamines 84-98 chromogranin A Homo sapiens 53-57 19820086-0 2010 Elucidation of the mechanism by which catecholamine stress hormones liberate iron from the innate immune defense proteins transferrin and lactoferrin. Catecholamines 38-51 transferrin Homo sapiens 122-133 19763821-1 2010 It is now becoming clear that two major systems namely the sympathetic nervous system and the renin-angiotensin system are activated in response to ischemic injury; these result in the elevation of plasma catecholamines and angiotensin II during the development of myocardial infarction as well as congestive heart failure. Catecholamines 205-219 renin Homo sapiens 94-99 21095460-1 2010 Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of catechol structured compounds such as catecholamines, catecholestrogens, and L-dopa. Catecholamines 118-132 catechol-O-methyltransferase Mus musculus 0-28 21095460-1 2010 Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of catechol structured compounds such as catecholamines, catecholestrogens, and L-dopa. Catecholamines 118-132 catechol-O-methyltransferase Mus musculus 30-34 19820086-7 2010 We also analyzed the transferrin-catecholamine interactions in human serum and found that therapeutically relevant concentrations of stress hormones and inotropes could directly affect the iron binding of serum-transferrin so that the normally highly bacteriostatic tissue fluid became significantly more supportive of the growth of bacteria. Catecholamines 33-46 transferrin Homo sapiens 21-32 19966186-0 2010 Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1. Catecholamines 44-57 sulfotransferase family 1D, member 1 Mus musculus 104-137 19966186-5 2010 Sult1d1, a sulfotransferase, is a member of a large superfamily of detoxification enzymes and has an important role in the inactivation of endogenous dopamine-derived compounds, including the catecholamines. Catecholamines 192-206 sulfotransferase family 1D, member 1 Mus musculus 0-7 19966186-11 2010 These results suggest that Sult1d1 in mice is directly induced by glucocorticoids and may attenuate elevated catecholamine activity during the stress response. Catecholamines 109-122 sulfotransferase family 1D, member 1 Mus musculus 27-34 19820086-2 2010 A major element of the growth induction process has been shown to involve the catecholamines binding to the high-affinity ferric-iron-binding proteins transferrin (Tf) and lactoferrin, which then enables bacterial acquisition of normally inaccessible sequestered host iron. Catecholamines 78-92 transferrin Homo sapiens 151-162 19820086-7 2010 We also analyzed the transferrin-catecholamine interactions in human serum and found that therapeutically relevant concentrations of stress hormones and inotropes could directly affect the iron binding of serum-transferrin so that the normally highly bacteriostatic tissue fluid became significantly more supportive of the growth of bacteria. Catecholamines 33-46 transferrin Homo sapiens 211-222 19820086-2 2010 A major element of the growth induction process has been shown to involve the catecholamines binding to the high-affinity ferric-iron-binding proteins transferrin (Tf) and lactoferrin, which then enables bacterial acquisition of normally inaccessible sequestered host iron. Catecholamines 78-92 transferrin Homo sapiens 164-166 19820086-4 2010 The present study employed electron paramagnetic resonance spectroscopy and chemical iron-binding analyses to demonstrate that catecholamine stress hormones form direct complexes with the ferric iron within transferrin and lactoferrin. Catecholamines 127-140 transferrin Homo sapiens 207-218 20009769-1 2010 RATIONALE: Dopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Catecholamines 70-83 dopamine beta-hydroxylase Homo sapiens 11-36 20009769-1 2010 RATIONALE: Dopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Catecholamines 70-83 dopamine beta-hydroxylase Homo sapiens 38-41 20616572-1 2010 BACKGROUND/AIMS: The plasma concentration of catecholamines and their metabolites generated by catechol-O-methyl transferase (COMT) were measured and their correlation with the progress of renal dysfunction was investigated in two distinctive animal models: a 5/6 nephrectomized Sprague-Dawley rat model and a 1/2 nephrectomized diabetic fatty Zucker rat model. Catecholamines 45-59 catechol-O-methyltransferase Rattus norvegicus 126-130 20037632-15 2009 They also show that neurotransmitter regulation in cell body regions can mediate behavioral outcomes and that ser31 TH phosphorylation plays a role in behaviors dependent upon catecholamines, such as dopamine. Catecholamines 176-190 tyrosine hydroxylase Rattus norvegicus 116-118 19835916-0 2010 Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein. Catecholamines 11-24 synuclein alpha Rattus norvegicus 83-98 19835916-0 2010 Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein. Catecholamines 11-24 synuclein alpha Homo sapiens 150-165 19835916-13 2010 Therefore, these findings suggest that the coexistence of human alpha-synuclein with catecholamine enhances the endoplasmic reticulum stress-related toxicity in PD pathogenesis. Catecholamines 85-98 synuclein alpha Homo sapiens 64-79 20974455-2 2010 COMT is one of the enzymes that metabolizes catecholamines, thereby acting as a key modulator of dopaminergic and adrenergic/noradrenergic neurotransmissions, which play a key role in pain modulation. Catecholamines 44-58 catechol-O-methyltransferase Homo sapiens 0-4 20004359-10 2010 Therefore, cTnI and PLB probably play a more central role in modulating contractile function in NRCMs in response to catecholamines than does MyBP-C, and MyBP-C may have a structural role in stabilizing thick filament assembly rather than influencing cross-bridge formation in developing hearts. Catecholamines 117-131 troponin I3, cardiac type Rattus norvegicus 11-15 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 tyrosine hydroxylase Rattus norvegicus 95-115 19999914-3 2009 Vasopressin has emerged as a possible pharmacologic adjunct, particularly in patients with shock refractory to the administration of fluids and catecholamines. Catecholamines 144-158 arginine vasopressin Homo sapiens 0-11 19857969-0 2009 Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. Catecholamines 87-101 adrenoceptor beta 2 Homo sapiens 43-70 19857969-4 2009 Here, through a combination of molecular modeling and site-directed mutagenesis, we have identified N293 in the beta(2)-adrenergic receptor as a crucial residue for the selectivity of the receptor for catecholamines fluorinated at different positions. Catecholamines 201-215 adrenoceptor beta 2 Homo sapiens 112-139 19632905-1 2009 Corticotropin-releasing factor (CRF) in the brain has been shown to stimulate sympathetic activity, leading to elevations of blood pressure, heart rate and plasma catecholamine levels and neuronal activation of the sympathetic ganglia and adrenal medulla. Catecholamines 163-176 corticotropin releasing hormone Rattus norvegicus 0-30 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 tyrosine hydroxylase Rattus norvegicus 117-119 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 dopamine beta-hydroxylase Rattus norvegicus 122-147 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 dopamine beta-hydroxylase Rattus norvegicus 149-152 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 phenylethanolamine-N-methyltransferase Rattus norvegicus 158-196 19893991-3 2009 In the present study, the changes in gene expression of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) and protein levels in the right and left heart auricles of naive control and long-term (12 weeks) socially isolated rats were investigated by Taqman RT-PCR and Western blot analysis. Catecholamines 60-73 phenylethanolamine-N-methyltransferase Rattus norvegicus 198-202 19837877-10 2009 These findings suggest that the cAMP increase induced by stimulation of beta(2)-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3. Catecholamines 155-169 adrenergic receptor, beta 2 Mus musculus 72-82 19837877-10 2009 These findings suggest that the cAMP increase induced by stimulation of beta(2)-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3. Catecholamines 155-169 F-box protein 32 Mus musculus 179-188 19837877-10 2009 These findings suggest that the cAMP increase induced by stimulation of beta(2)-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3. Catecholamines 155-169 thymoma viral proto-oncogene 1 Mus musculus 252-255 19837877-10 2009 These findings suggest that the cAMP increase induced by stimulation of beta(2)-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3. Catecholamines 155-169 forkhead box O3 Mus musculus 281-286 19801645-1 2009 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines, is activated by phosphorylation-dependent binding to 14-3-3 proteins. Catecholamines 72-86 tyrosine hydroxylase Homo sapiens 0-20 19959875-4 2009 Mice with a targeted deletion of the gene encoding Pdc (Pdc-/- mice) had increased blood pressure despite normal cardiac function and vascular reactivity, and displayed elevated catecholamine turnover in the peripheral sympathetic system. Catecholamines 178-191 phosducin Mus musculus 51-54 19959875-4 2009 Mice with a targeted deletion of the gene encoding Pdc (Pdc-/- mice) had increased blood pressure despite normal cardiac function and vascular reactivity, and displayed elevated catecholamine turnover in the peripheral sympathetic system. Catecholamines 178-191 phosducin Mus musculus 56-67 19881467-2 2009 The catechol-O-methyltransferase (COMT) gene, which is located in the 22q11 microdeletion, has been considered as a candidate gene for schizophrenia because of its ability to degrade catecholamines, including dopamine. Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 4-32 19881467-2 2009 The catechol-O-methyltransferase (COMT) gene, which is located in the 22q11 microdeletion, has been considered as a candidate gene for schizophrenia because of its ability to degrade catecholamines, including dopamine. Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 34-38 19966533-7 2009 Among them, we focused on catechol-O-methyltransferase (COMT) because this enzyme inactivates catecholamines, possibly affecting blood pressure. Catecholamines 94-108 catechol-O-methyltransferase Rattus norvegicus 26-54 19966533-7 2009 Among them, we focused on catechol-O-methyltransferase (COMT) because this enzyme inactivates catecholamines, possibly affecting blood pressure. Catecholamines 94-108 catechol-O-methyltransferase Rattus norvegicus 56-60 19698724-2 2009 The norepinephrine transporter (NET, SLC6A2) represents an important candidate gene for contribution to ADHD because it regulates catecholamine extracellular and tissue concentrations and contributes to executive functions disrupted in ADHD, and NET is a target for most effective ADHD therapeutics. Catecholamines 130-143 solute carrier family 6 member 2 Homo sapiens 4-30 19698724-2 2009 The norepinephrine transporter (NET, SLC6A2) represents an important candidate gene for contribution to ADHD because it regulates catecholamine extracellular and tissue concentrations and contributes to executive functions disrupted in ADHD, and NET is a target for most effective ADHD therapeutics. Catecholamines 130-143 solute carrier family 6 member 2 Homo sapiens 32-35 19698724-2 2009 The norepinephrine transporter (NET, SLC6A2) represents an important candidate gene for contribution to ADHD because it regulates catecholamine extracellular and tissue concentrations and contributes to executive functions disrupted in ADHD, and NET is a target for most effective ADHD therapeutics. Catecholamines 130-143 solute carrier family 6 member 2 Homo sapiens 37-43 19698724-2 2009 The norepinephrine transporter (NET, SLC6A2) represents an important candidate gene for contribution to ADHD because it regulates catecholamine extracellular and tissue concentrations and contributes to executive functions disrupted in ADHD, and NET is a target for most effective ADHD therapeutics. Catecholamines 130-143 solute carrier family 6 member 2 Homo sapiens 246-249 19706594-10 2009 Together, our studies revealed distinct roles of PKA and GRK phosphorylation of the beta(2)AR for agonist dose-dependent coupling to G(i) proteins in cardiac myocytes, which may protect cells from overstimulation under high concentrations of catecholamines. Catecholamines 242-256 G protein-coupled receptor kinase 4 Mus musculus 57-60 19706594-10 2009 Together, our studies revealed distinct roles of PKA and GRK phosphorylation of the beta(2)AR for agonist dose-dependent coupling to G(i) proteins in cardiac myocytes, which may protect cells from overstimulation under high concentrations of catecholamines. Catecholamines 242-256 adrenergic receptor, beta 2 Mus musculus 84-93 19801645-1 2009 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines, is activated by phosphorylation-dependent binding to 14-3-3 proteins. Catecholamines 72-86 tyrosine hydroxylase Homo sapiens 22-24 19733607-5 2009 The MAO-A-dependent catecholamine metabolite DHPG levels did not change significantly during the study suggesting that rasagiline"s MAO-B selectivity was preserved. Catecholamines 20-33 monoamine oxidase A Homo sapiens 4-9 19280369-1 2009 Catecholamine-regulated proteins (CRPs) have been shown to bind dopamine and other structurally related catecholamines; in particular, the 40-kDa CRP (CRP40) protein has been previously cloned and functionally characterized. Catecholamines 104-118 heat shock protein family A (Hsp70) member 9 Homo sapiens 34-37 19280369-1 2009 Catecholamine-regulated proteins (CRPs) have been shown to bind dopamine and other structurally related catecholamines; in particular, the 40-kDa CRP (CRP40) protein has been previously cloned and functionally characterized. Catecholamines 104-118 heat shock protein family A (Hsp70) member 9 Homo sapiens 151-156 19396395-0 2009 Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines. Catecholamines 66-80 tyrosine hydroxylase Homo sapiens 22-42 19396395-1 2009 Tyrosine hydroxylase (TH) catalyzes the conversion of L: -tyrosine to L: -dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [CA; dopamine (DA), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of CA. Catecholamines 147-161 tyrosine hydroxylase Homo sapiens 0-20 19396395-1 2009 Tyrosine hydroxylase (TH) catalyzes the conversion of L: -tyrosine to L: -dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [CA; dopamine (DA), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of CA. Catecholamines 147-161 tyrosine hydroxylase Homo sapiens 22-24 19333138-3 2009 However, the consequences of beta-AR activation by endogenous catecholamines have not been explored in these settings. Catecholamines 62-76 adrenergic receptor, beta 1 Mus musculus 29-36 19671882-3 2009 nAChRs formed by alpha3, alpha5, and beta4 subunits may regulate blood pressure (BP) by mediating release of catestatin, the endogenous nicotinic antagonist fragment of chromogranin A (CHGA) and potent inhibitor of catecholamine secretion. Catecholamines 215-228 chromogranin A Homo sapiens 109-119 19671882-3 2009 nAChRs formed by alpha3, alpha5, and beta4 subunits may regulate blood pressure (BP) by mediating release of catestatin, the endogenous nicotinic antagonist fragment of chromogranin A (CHGA) and potent inhibitor of catecholamine secretion. Catecholamines 215-228 chromogranin A Homo sapiens 185-189 19671882-11 2009 Studies of chromaffin cells in vitro reveal that nicotinic agonist stimulation releases catecholamines and CHGA, a process augmented by overexpression of CHRNA3 and blocked by catestatin. Catecholamines 88-102 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 154-160 19333138-5 2009 Our first goal was therefore to determine the impact of beta-AR stimulation by endogenous catecholamines released during endotoxemia on LPS-mediated inflammation and mortality in vivo. Catecholamines 90-104 adrenergic receptor, beta 1 Mus musculus 56-63 19703163-1 2009 BACKGROUND AND PURPOSE: This study investigates the role of alpha(2)-adrenoceptor subtypes, alpha(2A), alpha(2B) and alpha(2C), on catecholamine synthesis and catabolism in the central nervous system of mice. Catecholamines 131-144 adrenergic receptor, alpha 2a Mus musculus 92-100 19576971-2 2009 MDA and BDB are mainly metabolized via demethylenation to the corresponding catecholamines. Catecholamines 76-90 receptor tyrosine kinase like orphan receptor 2 Homo sapiens 8-11 19394418-8 2009 Conversely, catecholamine-stimulated interleukin-10 (IL-10) production by blood monocytes exerts immunosuppressive effects. Catecholamines 12-25 interleukin 10 Homo sapiens 37-51 19394418-8 2009 Conversely, catecholamine-stimulated interleukin-10 (IL-10) production by blood monocytes exerts immunosuppressive effects. Catecholamines 12-25 interleukin 10 Homo sapiens 53-58 19713945-11 2009 CONCLUSION: Thus, absence of S100B is associated with attenuation of the hemodynamic response to catecholamines, in contradistinction to, the augmented cardiac hypertrophy and smooth muscle cell proliferation. Catecholamines 97-111 S100 protein, beta polypeptide, neural Mus musculus 29-34 19703163-1 2009 BACKGROUND AND PURPOSE: This study investigates the role of alpha(2)-adrenoceptor subtypes, alpha(2A), alpha(2B) and alpha(2C), on catecholamine synthesis and catabolism in the central nervous system of mice. Catecholamines 131-144 adrenergic receptor, alpha 2b Mus musculus 103-111 19703163-1 2009 BACKGROUND AND PURPOSE: This study investigates the role of alpha(2)-adrenoceptor subtypes, alpha(2A), alpha(2B) and alpha(2C), on catecholamine synthesis and catabolism in the central nervous system of mice. Catecholamines 131-144 adrenergic receptor, alpha 2c Mus musculus 117-125 19703163-2 2009 EXPERIMENTAL APPROACH: Activities of the main catecholamine synthetic and catabolic enzymes were determined in whole brains obtained from alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knockout (KO) and C56Bl\7 wild-type (WT) mice. Catecholamines 46-59 adrenergic receptor, alpha 2a Mus musculus 138-146 19703163-2 2009 EXPERIMENTAL APPROACH: Activities of the main catecholamine synthetic and catabolic enzymes were determined in whole brains obtained from alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knockout (KO) and C56Bl\7 wild-type (WT) mice. Catecholamines 46-59 adrenergic receptor, alpha 2b Mus musculus 150-158 19703163-2 2009 EXPERIMENTAL APPROACH: Activities of the main catecholamine synthetic and catabolic enzymes were determined in whole brains obtained from alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knockout (KO) and C56Bl\7 wild-type (WT) mice. Catecholamines 46-59 adrenergic receptor, alpha 2c Mus musculus 165-173 19703163-10 2009 CONCLUSIONS AND IMPLICATIONS: In mouse brain, deletion of alpha(2A)- or alpha(2C)-adrenoceptors increased cerebral aromatic L-amino acid decarboxylase activity and catecholamine tissue levels. Catecholamines 164-177 adrenergic receptor, alpha 2a Mus musculus 58-66 19703163-10 2009 CONCLUSIONS AND IMPLICATIONS: In mouse brain, deletion of alpha(2A)- or alpha(2C)-adrenoceptors increased cerebral aromatic L-amino acid decarboxylase activity and catecholamine tissue levels. Catecholamines 164-177 adrenergic receptor, alpha 2c Mus musculus 72-80 19496170-1 2009 The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the glucagon/vasoactive intestinal peptide (VIP) superfamily, stimulates cyclic AMP accumulation initiating a variety of biological processes such as: neurotropic actions, immune and pituitary function, learning and memory, catecholamine biosynthesis and regulation of cardiopulmonary function. Catecholamines 313-326 adenylate cyclase activating polypeptide 1 Mus musculus 69-74 19603179-1 2009 Tyrosine hydroxylase (TH) is a rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 75-89 tyrosine hydroxylase Danio rerio 0-20 19603179-1 2009 Tyrosine hydroxylase (TH) is a rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 75-89 tyrosine hydroxylase Danio rerio 22-24 19603179-9 2009 th2 may be a novel essential factor in regulation of catecholamine synthesis in zebrafish. Catecholamines 53-66 tyrosine hydroxylase 2 Danio rerio 0-3 19496170-1 2009 The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the glucagon/vasoactive intestinal peptide (VIP) superfamily, stimulates cyclic AMP accumulation initiating a variety of biological processes such as: neurotropic actions, immune and pituitary function, learning and memory, catecholamine biosynthesis and regulation of cardiopulmonary function. Catecholamines 313-326 vasoactive intestinal polypeptide Mus musculus 93-131 19496170-1 2009 The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the glucagon/vasoactive intestinal peptide (VIP) superfamily, stimulates cyclic AMP accumulation initiating a variety of biological processes such as: neurotropic actions, immune and pituitary function, learning and memory, catecholamine biosynthesis and regulation of cardiopulmonary function. Catecholamines 313-326 vasoactive intestinal polypeptide Mus musculus 133-136 19448984-1 2009 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is inhibited in vitro by catecholamines binding to two distinct sites on the enzyme. Catecholamines 55-68 tyrosine hydroxylase Rattus norvegicus 0-20 19629819-3 2009 Acute secretion of EGF from these glands protects the heart against catecholamine-induced injury. Catecholamines 68-81 epidermal growth factor Mus musculus 19-22 19620256-1 2009 Tyrosine hydroxylase (TH) plays a critical role in maintaining the appropriate concentrations of catecholamine neurotransmitters in brain and periphery, particularly during long-term stress, long-term drug treatment, or neurodegenerative diseases. Catecholamines 97-110 tyrosine hydroxylase Mus musculus 0-20 19620256-1 2009 Tyrosine hydroxylase (TH) plays a critical role in maintaining the appropriate concentrations of catecholamine neurotransmitters in brain and periphery, particularly during long-term stress, long-term drug treatment, or neurodegenerative diseases. Catecholamines 97-110 tyrosine hydroxylase Mus musculus 22-24 19448984-1 2009 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is inhibited in vitro by catecholamines binding to two distinct sites on the enzyme. Catecholamines 55-68 tyrosine hydroxylase Rattus norvegicus 22-24 19448984-1 2009 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is inhibited in vitro by catecholamines binding to two distinct sites on the enzyme. Catecholamines 108-122 tyrosine hydroxylase Rattus norvegicus 0-20 19448984-1 2009 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is inhibited in vitro by catecholamines binding to two distinct sites on the enzyme. Catecholamines 108-122 tyrosine hydroxylase Rattus norvegicus 22-24 19591812-1 2009 Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is known to contain naturally occurring genetic variation in it"s promoter region that associates with a number of neuropsychological disorders. Catecholamines 50-63 tyrosine hydroxylase Homo sapiens 0-20 19539715-2 2009 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway, responsible for epinephrine biosynthesis, and is primarily localized in the adrenal gland. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 19539715-2 2009 Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway, responsible for epinephrine biosynthesis, and is primarily localized in the adrenal gland. Catecholamines 76-89 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 19719781-3 2009 As catecholamines are often increased in cardiac diseases, Salameh et al., in this issue of the BJP, investigated the effect of beta-adrenoceptor stimulation of neonatal cardiomyocytes on Cx43 expression and found increased Cx43 mRNA and protein levels following 24 h stimulation. Catecholamines 3-17 gap junction protein alpha 1 Homo sapiens 188-192 19572935-1 2009 BACKGROUND: The beneficial effects of vasopressin on diuresis and creatinine clearance have been demonstrated when used as an additional/alternative therapy in catecholamine-dependent vasodilatory shock. Catecholamines 160-173 arginine vasopressin Homo sapiens 38-49 19719781-3 2009 As catecholamines are often increased in cardiac diseases, Salameh et al., in this issue of the BJP, investigated the effect of beta-adrenoceptor stimulation of neonatal cardiomyocytes on Cx43 expression and found increased Cx43 mRNA and protein levels following 24 h stimulation. Catecholamines 3-17 gap junction protein alpha 1 Homo sapiens 224-228 19652718-11 2009 Noteworthy, TNAP may contribute to the regulation of serotonin or catecholamine synthesis in 1C11(5-HT) and 1C11(NE) bioaminergic cells by controlling pyridoxal phosphate levels. Catecholamines 66-79 alkaline phosphatase, liver/bone/kidney Mus musculus 12-16 20074440-2 2009 Catechol-O-methyltransferase (COMT) is the major catecholamine-clearing pathway and involved in the mediation of pain perception in humans, and the hypothesized role of pain perception in FM. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 0-28 20074440-2 2009 Catechol-O-methyltransferase (COMT) is the major catecholamine-clearing pathway and involved in the mediation of pain perception in humans, and the hypothesized role of pain perception in FM. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 30-34 19464960-3 2009 We sought to investigate the relationships between catecholamine-related polymorphisms [dopamine-D(3) receptor (DRD3) Ser9Gly and catechol-O-methyltransferase (COMT) Val158Met] and thermal pain measures in healthy subjects and FM patients. Catecholamines 51-64 dopamine receptor D3 Homo sapiens 112-116 19464960-3 2009 We sought to investigate the relationships between catecholamine-related polymorphisms [dopamine-D(3) receptor (DRD3) Ser9Gly and catechol-O-methyltransferase (COMT) Val158Met] and thermal pain measures in healthy subjects and FM patients. Catecholamines 51-64 catechol-O-methyltransferase Homo sapiens 130-158 19464960-3 2009 We sought to investigate the relationships between catecholamine-related polymorphisms [dopamine-D(3) receptor (DRD3) Ser9Gly and catechol-O-methyltransferase (COMT) Val158Met] and thermal pain measures in healthy subjects and FM patients. Catecholamines 51-64 catechol-O-methyltransferase Homo sapiens 160-164 19396873-0 2009 Interleukin-6 increases intracellular Ca2+ concentration and induces catecholamine secretion in rat carotid body glomus cells. Catecholamines 69-82 interleukin 6 Rattus norvegicus 0-13 19396873-4 2009 To explore the effect of IL-6 on CB, here we examine the effect of IL-6 on [Ca(2+)](i) and catecholamine (CA) secretion in rat CB glomus cells. Catecholamines 91-104 interleukin 6 Rattus norvegicus 67-71 18649956-5 2009 Since it is well known that myocardial damage caused by catecholamines can induce synthesis of cytokines by myocytes, cytokines, specifically those with known cardiodepressant properties such as TNF-alpha, could be an alternative mechanism involved in cardiac dysfunction in the setting of tetanus. Catecholamines 56-70 tumor necrosis factor Homo sapiens 195-204 19508428-0 2009 PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway. Catecholamines 26-39 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 19674087-4 2009 The present study demonstrates that the adrenal medulla and sympathetic ganglia of Mecp2 null mice exhibit markedly reduced catecholamine content compared with wild-type controls. Catecholamines 124-137 methyl CpG binding protein 2 Mus musculus 83-88 19507019-1 2009 The beta(3)-adrenergic receptor (ADRB3) is the main mediator of the lipolytic and thermogenic effects of high catecholamine concentrations. Catecholamines 110-123 beta-3 adrenergic receptor Ovis aries 4-31 19507019-1 2009 The beta(3)-adrenergic receptor (ADRB3) is the main mediator of the lipolytic and thermogenic effects of high catecholamine concentrations. Catecholamines 110-123 beta-3 adrenergic receptor Ovis aries 33-38 19640370-0 2009 The long-term survival rate of catecholamine-resistant septic shock in Japanese patients who received vasopressin therapy. Catecholamines 31-44 arginine vasopressin Homo sapiens 102-113 19640370-3 2009 METHODS: 55 Japanese patients experiencing catecholamine-resistant septic shock were treated with vasopressin. Catecholamines 43-56 arginine vasopressin Homo sapiens 98-109 19640370-9 2009 CONCLUSIONS: In Japanese septic shock patients, vasopressin infusion improved hemodynamic status and reduced catecholamine requirement, and 28-day survival rate was 45%. Catecholamines 109-122 arginine vasopressin Homo sapiens 48-59 19372204-1 2009 Chromogranin A (CgA), the major soluble protein in chromaffin granules, is proteolytically processed to generate biologically active peptides including the catecholamine release inhibitory peptide catestatin. Catecholamines 156-169 chromogranin A Rattus norvegicus 0-14 19372204-1 2009 Chromogranin A (CgA), the major soluble protein in chromaffin granules, is proteolytically processed to generate biologically active peptides including the catecholamine release inhibitory peptide catestatin. Catecholamines 156-169 chromogranin A Rattus norvegicus 16-19 19372204-9 2009 The pool of peptides generated from the CTSL cleavage of CgA inhibited nicotine-induced catecholamine secretion from PC12 cells. Catecholamines 88-101 cathepsin L Rattus norvegicus 40-44 19372204-9 2009 The pool of peptides generated from the CTSL cleavage of CgA inhibited nicotine-induced catecholamine secretion from PC12 cells. Catecholamines 88-101 chromogranin A Rattus norvegicus 57-60 19672024-9 2009 CONCLUSION: Our results indicate that serum total and HMW Adp, and AdpR1 gene expressions in pheochromocytoma tissue, are associated with the level of catecholamine produced in the tumor. Catecholamines 151-164 adiponectin, C1Q and collagen domain containing Homo sapiens 58-61 19672024-9 2009 CONCLUSION: Our results indicate that serum total and HMW Adp, and AdpR1 gene expressions in pheochromocytoma tissue, are associated with the level of catecholamine produced in the tumor. Catecholamines 151-164 adiponectin receptor 1 Homo sapiens 67-72 19672024-10 2009 It is tempting to speculate that catecholamine induces adiponectin production and signaling. Catecholamines 33-46 adiponectin, C1Q and collagen domain containing Homo sapiens 55-66 19508428-7 2009 In this study we utilize native neuronal stimulation of adrenal chromaffin cells in situ and amperometric catecholamine detection to demonstrate that PACAP specifically elicits catecholamine release under elevated splanchnic firing. Catecholamines 106-119 adenylate cyclase activating polypeptide 1 Homo sapiens 150-155 19508428-7 2009 In this study we utilize native neuronal stimulation of adrenal chromaffin cells in situ and amperometric catecholamine detection to demonstrate that PACAP specifically elicits catecholamine release under elevated splanchnic firing. Catecholamines 177-190 adenylate cyclase activating polypeptide 1 Homo sapiens 150-155 19508428-8 2009 Further data reveal that the immediate PACAP-evoked stimulation involves a phospholipase C and protein kinase C-dependent pathway to facilitate calcium influx through a Ni2+ and mibefradil-sensitive calcium conductance that results in catecholamine release. Catecholamines 235-248 adenylate cyclase activating polypeptide 1 Homo sapiens 39-44 19246490-9 2009 Further, deletion of INSM1 severely impairs catecholamine biosynthesis and secretion from the adrenal gland that results in early embryonic lethality. Catecholamines 44-57 insulinoma-associated 1 Mus musculus 21-26 19671753-2 2009 One important marker for NB is the expression of tyrosine hydroxylase (TH), the first-step enzyme of catecholamine biosynthesis. Catecholamines 101-114 tyrosine hydroxylase Homo sapiens 49-69 19671753-2 2009 One important marker for NB is the expression of tyrosine hydroxylase (TH), the first-step enzyme of catecholamine biosynthesis. Catecholamines 101-114 tyrosine hydroxylase Homo sapiens 71-73 19576569-1 2009 In humans, three genes--ADRB1, ADRB2 and ADRB3--encode beta-adrenoreceptors (ADRB); these molecules mediate the action of catecholamines in multiple tissues and play pivotal roles in cardiovascular, respiratory, metabolic, and immunological functions. Catecholamines 122-136 adrenoceptor beta 1 Homo sapiens 24-29 19576569-1 2009 In humans, three genes--ADRB1, ADRB2 and ADRB3--encode beta-adrenoreceptors (ADRB); these molecules mediate the action of catecholamines in multiple tissues and play pivotal roles in cardiovascular, respiratory, metabolic, and immunological functions. Catecholamines 122-136 adrenoceptor beta 2 Homo sapiens 31-36 19576569-1 2009 In humans, three genes--ADRB1, ADRB2 and ADRB3--encode beta-adrenoreceptors (ADRB); these molecules mediate the action of catecholamines in multiple tissues and play pivotal roles in cardiovascular, respiratory, metabolic, and immunological functions. Catecholamines 122-136 adrenoceptor beta 3 Homo sapiens 41-46 19179436-3 2009 This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis in adrenalectomized (ADX) rats supplemented with low CORT pellet (ADX plus CORT). Catecholamines 163-176 tyrosine hydroxylase Rattus norvegicus 108-128 19179436-3 2009 This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis in adrenalectomized (ADX) rats supplemented with low CORT pellet (ADX plus CORT). Catecholamines 163-176 tyrosine hydroxylase Rattus norvegicus 130-132 19471322-2 2009 In this pathway, renalase, a novel secreted amine oxidase that is inactive at baseline, is rapidly turned on ( ~ 10 fold increase) by either a modest increase in blood pressure or by brief surges in plasma catecholamines. Catecholamines 206-220 renalase, FAD dependent amine oxidase Homo sapiens 17-25 19471322-4 2009 Plasma catecholamines not only activate renalase enzymatic activity but also lead to a 3-4 fold stimulation of renalase secretion. Catecholamines 7-21 renalase, FAD dependent amine oxidase Homo sapiens 40-48 19471322-4 2009 Plasma catecholamines not only activate renalase enzymatic activity but also lead to a 3-4 fold stimulation of renalase secretion. Catecholamines 7-21 renalase, FAD dependent amine oxidase Homo sapiens 111-119 19509284-5 2009 Although catecholamine stimulation mediates the retention of beta1AR-EGFR interaction throughout receptor internalization, direct EGF ligand stimulation initiates the internalization of EGFR alone. Catecholamines 9-22 adrenoceptor beta 1 Homo sapiens 61-68 19509284-7 2009 These data reveal a new signaling paradigm in which beta-arrestin is required for the maintenance of a beta1AR-EGFR interaction that can direct cytosolic targeting of ERK in response to catecholamine stimulation. Catecholamines 186-199 adrenoceptor beta 1 Homo sapiens 103-115 19509284-7 2009 These data reveal a new signaling paradigm in which beta-arrestin is required for the maintenance of a beta1AR-EGFR interaction that can direct cytosolic targeting of ERK in response to catecholamine stimulation. Catecholamines 186-199 mitogen-activated protein kinase 1 Homo sapiens 167-170 19621359-1 2009 A sensitive and efficient analysis of amino acids and catecholamines is currently presented with 3-(4-bromobenzoyl)-2-quinolinecarboxaldehyde as a fluorogenic derivatization reagent using CE separation with LIF detection. Catecholamines 54-68 LIF interleukin 6 family cytokine Homo sapiens 207-210 19457096-7 2009 These data suggest that a basal level of HIF-2alpha function is required for the normal developmental expression of DDC and DbetaH in SA progenitor cells, and that loss of this function leads to impaired catecholamine biosynthesis. Catecholamines 204-217 endothelial PAS domain protein 1 Rattus norvegicus 41-51 19307158-2 2009 Previously, we reported that inducible nitric oxide synthase (iNOS) is involved in central CRF-induced elevation of plasma catecholamines in rats. Catecholamines 123-137 nitric oxide synthase 2 Rattus norvegicus 29-60 19307158-2 2009 Previously, we reported that inducible nitric oxide synthase (iNOS) is involved in central CRF-induced elevation of plasma catecholamines in rats. Catecholamines 123-137 nitric oxide synthase 2 Rattus norvegicus 62-66 19500370-4 2009 The following study examined if exogenous Sry1 or Sry2 delivered to the kidney would elevate renal tyrosine hydroxylase, renal catecholamines, plasma catecholamines and telemetered BP over a 28 day period. Catecholamines 127-141 sex determining region Y Rattus norvegicus 42-46 19500370-4 2009 The following study examined if exogenous Sry1 or Sry2 delivered to the kidney would elevate renal tyrosine hydroxylase, renal catecholamines, plasma catecholamines and telemetered BP over a 28 day period. Catecholamines 150-164 sex determining region Y Rattus norvegicus 42-46 19483313-2 2009 The purpose of the present study was to test whether isoproterenol, one of the synthetic catecholamines having beta-adrenergic activity, affected angiotensin II (Ang II)-induced cell proliferation and reactive oxygen species (ROS) production. Catecholamines 89-103 angiotensinogen Rattus norvegicus 146-160 19318513-3 2009 Leptin mRNA levels are regulated by hormones, including glucocorticoids and catecholamines, but little is known about the transcriptional mechanisms involved. Catecholamines 76-90 leptin Homo sapiens 0-6 19483313-2 2009 The purpose of the present study was to test whether isoproterenol, one of the synthetic catecholamines having beta-adrenergic activity, affected angiotensin II (Ang II)-induced cell proliferation and reactive oxygen species (ROS) production. Catecholamines 89-103 angiotensinogen Rattus norvegicus 162-168 19372624-8 2009 CONCLUSIONS: Emotional stress and a surge of catecholamine upregulate HO-1 in the cardiac and aortic macrophages. Catecholamines 45-58 heme oxygenase 1 Rattus norvegicus 70-74 19189136-3 2009 We report a case of an 8-year-old white girl with a 3-year history of catecholamine excess-related complaints who was diagnosed with a malignant SDHB-associated mediastinal paraganglioma. Catecholamines 70-83 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 145-149 19462939-2 2009 As the elimination of the catecholamine metabolites could also be enantioselective, the aim of the present study was to investigate the O-methylation to the corresponding methoxy derivatives catalyzed by the soluble or membrane-bound form of the catechol-O-methyltransferase (COMT). Catecholamines 26-39 catechol-O-methyltransferase Homo sapiens 246-274 19462939-2 2009 As the elimination of the catecholamine metabolites could also be enantioselective, the aim of the present study was to investigate the O-methylation to the corresponding methoxy derivatives catalyzed by the soluble or membrane-bound form of the catechol-O-methyltransferase (COMT). Catecholamines 26-39 catechol-O-methyltransferase Homo sapiens 276-280 19462939-8 2009 Our data showed that the S-enantiomers of all studied catecholamines were preferably O-methylated by both types of COMT. Catecholamines 54-68 catechol-O-methyltransferase Homo sapiens 115-119 19208735-8 2009 The frequency of symptoms, hypertension and the magnitude of catecholamine secretion appeared to be greater in the SDHB cohort. Catecholamines 61-74 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 115-119 19208735-10 2009 These data indicate that SDHB-related tumours are predominantly extra-adrenal in location and associated with higher catecholamine secretion and more malignant disease, in subjects who appear more symptomatic. Catecholamines 117-130 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 25-29 19406978-1 2009 Enzymatic pathways involving catechol-O-methyltransferase (COMT) catabolize circulating catecholamines. Catecholamines 88-102 catechol-O-methyltransferase Homo sapiens 29-57 19406978-1 2009 Enzymatic pathways involving catechol-O-methyltransferase (COMT) catabolize circulating catecholamines. Catecholamines 88-102 catechol-O-methyltransferase Homo sapiens 59-63 19406978-3 2009 We enrolled 260 patients postbypass surgery to test the hypothesis that COMT gene variants impair circulating catecholamine metabolism, predisposing to shock and acute kidney injury (AKI) after cardiac surgery. Catecholamines 110-123 catechol-O-methyltransferase Homo sapiens 72-76 19172410-1 2009 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency is a disorder of biogenic amine metabolism resulting in generalized combined deficiency of serotonin, dopamine and catecholamines. Catecholamines 181-195 dopa decarboxylase Homo sapiens 12-47 19172410-1 2009 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency is a disorder of biogenic amine metabolism resulting in generalized combined deficiency of serotonin, dopamine and catecholamines. Catecholamines 181-195 dopa decarboxylase Homo sapiens 49-53 19328209-1 2009 Several studies have shown that catecholamines can inhibit the fibrillation of alpha-synuclein (alpha-Syn), a small presynaptic protein whose aggregation is believed to be a critical step in the etiology of Parkinson"s disease and several other neurodegenerative disorders. Catecholamines 32-46 synuclein alpha Homo sapiens 79-94 19268435-1 2009 Catechol-O-methyltransferase (COMT) plays an important role in brain catecholamine metabolism. Catecholamines 69-82 catechol-O-methyltransferase Homo sapiens 0-28 19268435-1 2009 Catechol-O-methyltransferase (COMT) plays an important role in brain catecholamine metabolism. Catecholamines 69-82 catechol-O-methyltransferase Homo sapiens 30-34 19328209-1 2009 Several studies have shown that catecholamines can inhibit the fibrillation of alpha-synuclein (alpha-Syn), a small presynaptic protein whose aggregation is believed to be a critical step in the etiology of Parkinson"s disease and several other neurodegenerative disorders. Catecholamines 32-46 synuclein alpha Homo sapiens 96-105 19309436-6 2009 Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation. Catecholamines 29-42 interleukin 1 beta Homo sapiens 10-18 19250273-5 2009 The expression of tyrosine hydroxylase (TH) and dopamine b-hydroxylase (DBH), two rate-limiting enzymes in catecholamine synthesis, was detected by immunohistochemistry in murine colitis. Catecholamines 107-120 dopamine beta hydroxylase Mus musculus 72-75 19309436-0 2009 Regulation of catecholamine release and tyrosine hydroxylase in human adrenal chromaffin cells by interleukin-1beta: role of neuropeptide Y and nitric oxide. Catecholamines 14-27 interleukin 1 beta Homo sapiens 98-115 19907751-1 2009 Exhaustion of catecholamine depot in the CNS before modeling of cytostatic myelosuppression potentiates the stimulatory effect of granulocytic CSF on regeneration of the granulocytic hemopoiesis stem. Catecholamines 14-27 colony stimulating factor 2 Homo sapiens 143-146 19309436-2 2009 The aim of our work was to study the role of the cytokine interleukin-1beta (IL-1beta) on catecholamine release and synthesis from primary cell cultures of human adrenal chromaffin cells. Catecholamines 90-103 interleukin 1 beta Homo sapiens 58-75 19309436-6 2009 Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation. Catecholamines 29-42 interleukin 1 beta Homo sapiens 105-113 19309436-2 2009 The aim of our work was to study the role of the cytokine interleukin-1beta (IL-1beta) on catecholamine release and synthesis from primary cell cultures of human adrenal chromaffin cells. Catecholamines 90-103 interleukin 1 beta Homo sapiens 77-85 19309436-6 2009 Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation. Catecholamines 121-134 interleukin 1 beta Homo sapiens 10-18 19309436-3 2009 The effect of IL-1beta on neuropeptide Y (NPY) release and the intracellular pathways involved in catecholamine release evoked by IL-1beta and NPY were also investigated. Catecholamines 98-111 interleukin 1 beta Homo sapiens 130-138 19309436-6 2009 Moreover, IL-1beta regulates catecholamine synthesis as the inhibition of tyrosine hydroxylase decreases IL-1beta-evoked catecholamine release and the cytokine induces tyrosine hydroxylase Ser40 phosphorylation. Catecholamines 121-134 interleukin 1 beta Homo sapiens 105-113 19309436-3 2009 The effect of IL-1beta on neuropeptide Y (NPY) release and the intracellular pathways involved in catecholamine release evoked by IL-1beta and NPY were also investigated. Catecholamines 98-111 neuropeptide Y Homo sapiens 143-146 19309436-7 2009 Moreover, IL-1beta induces catecholamine release by a mitogen-activated protein kinase (MAPK)-dependent mechanism, and by nitric oxide synthase activation. Catecholamines 27-40 interleukin 1 beta Homo sapiens 10-18 19309436-8 2009 Furthermore, MAPK, protein kinase C (PKC), protein kinase A (PKA), and nitric oxide (NO) production are involved in catecholamine release evoked by NPY. Catecholamines 116-129 neuropeptide Y Homo sapiens 148-151 19309436-5 2009 Moreover, the immunoneutralization of released NPY inhibits catecholamine release evoked by IL-1beta. Catecholamines 60-73 neuropeptide Y Homo sapiens 47-50 19309436-5 2009 Moreover, the immunoneutralization of released NPY inhibits catecholamine release evoked by IL-1beta. Catecholamines 60-73 interleukin 1 beta Homo sapiens 92-100 19167205-1 2009 We examine here the electropolymerization of electrochemically or chemically preoxidized catecholamines in glucose oxidase (GOx)-containing neutral solutions to efficiently immobilize the enzyme at Prussian blue-modified Au electrodes for sensitive amperometric biosensing of glucose. Catecholamines 89-103 hydroxyacid oxidase 1 Homo sapiens 107-122 19232685-0 2009 Reduced GPIIb/IIIa expression in platelets hyposensitive to catecholamines when activated with TRAP. Catecholamines 60-74 integrin subunit alpha 2b Homo sapiens 8-13 19232685-0 2009 Reduced GPIIb/IIIa expression in platelets hyposensitive to catecholamines when activated with TRAP. Catecholamines 60-74 TRAP Homo sapiens 95-99 30625797-6 2009 This report describes our experience of the anesthetic management for the removal of pheochromocytoma with catecholamine-induced cardiomyopathy, which barely responded to high vasopressin and epinephrine. Catecholamines 107-120 arginine vasopressin Homo sapiens 176-187 19299911-0 2009 Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts. Catecholamines 83-96 caveolin 3 Rattus norvegicus 18-28 19299911-0 2009 Modulation of the caveolin-3 localization to caveolae and STAT3 to mitochondria by catecholamine-induced cardiac hypertrophy in H9c2 cardiomyoblasts. Catecholamines 83-96 signal transducer and activator of transcription 3 Rattus norvegicus 58-63 19299911-2 2009 Caveolin-3 localization to plasma membrane was attenuated and localization of caveolin-3 to caveolae in the plasma membrane was 24.3% reduced by the catecholamine- induced hypertrophy. Catecholamines 149-162 caveolin 3 Rattus norvegicus 0-10 19299911-2 2009 Caveolin-3 localization to plasma membrane was attenuated and localization of caveolin-3 to caveolae in the plasma membrane was 24.3% reduced by the catecholamine- induced hypertrophy. Catecholamines 149-162 caveolin 3 Rattus norvegicus 78-88 19299911-5 2009 Immunofluorescence analysis revealed that the catecholamine- induced hypertrophy promoted nuclear localization of pY705-STAT3. Catecholamines 46-59 signal transducer and activator of transcription 3 Rattus norvegicus 120-125 19299911-6 2009 Of interest, phosphorylation of pS727- STAT3 in mitochondria was significantly reduced by catecholamine-induced hypertrophy. Catecholamines 90-103 signal transducer and activator of transcription 3 Rattus norvegicus 39-44 19299911-8 2009 Our data suggest that the alterations in nuclear and mitochondrial activation of STAT3 and caveolae localization of caveolin-3 are related to the development of the catecholamine-induced cardiac hypertrophy. Catecholamines 165-178 signal transducer and activator of transcription 3 Rattus norvegicus 81-86 19299911-8 2009 Our data suggest that the alterations in nuclear and mitochondrial activation of STAT3 and caveolae localization of caveolin-3 are related to the development of the catecholamine-induced cardiac hypertrophy. Catecholamines 165-178 caveolin 3 Rattus norvegicus 116-126 19167205-0 2009 Electropolymerization of preoxidized catecholamines on Prussian blue matrix to immobilize glucose oxidase for sensitive amperometric biosensing. Catecholamines 37-51 hydroxyacid oxidase 1 Homo sapiens 90-105 19167205-1 2009 We examine here the electropolymerization of electrochemically or chemically preoxidized catecholamines in glucose oxidase (GOx)-containing neutral solutions to efficiently immobilize the enzyme at Prussian blue-modified Au electrodes for sensitive amperometric biosensing of glucose. Catecholamines 89-103 hydroxyacid oxidase 1 Homo sapiens 124-127 19276108-9 2009 These studies show the tightly coupled, but previously unanticipated, relationship of CaMKII to the betaAR pathway in fight or flight physiology and establish CaMKII as a critical signaling molecule for physiological HR responses to catecholamines. Catecholamines 233-247 calcium/calmodulin-dependent protein kinase II, beta Mus musculus 159-165 18802928-2 2009 The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680) polymorphism in ADHD have been inconsistent. Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 11-39 18802928-2 2009 The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680) polymorphism in ADHD have been inconsistent. Catecholamines 82-96 catechol-O-methyltransferase Homo sapiens 41-45 19691565-9 2009 CONCLUSION: Vasopressin (0.01-0.04 U/min, IV) should be considered in small animal veterinary patients with vasodilatory shock that is unresponsive to fluid resuscitation and catecholamine (dobutamine, dopamine, and norepinephrine) administration. Catecholamines 175-188 arginine vasopressin Homo sapiens 12-23 19190257-0 2009 Enhancement of aldosterone-induced catecholamine production by bone morphogenetic protein-4 through activating Rho and SAPK/JNK pathway in adrenomedullar cells. Catecholamines 35-48 bone morphogenetic protein 4 Rattus norvegicus 63-91 19190257-0 2009 Enhancement of aldosterone-induced catecholamine production by bone morphogenetic protein-4 through activating Rho and SAPK/JNK pathway in adrenomedullar cells. Catecholamines 35-48 mitogen-activated protein kinase 9 Rattus norvegicus 119-123 19190257-0 2009 Enhancement of aldosterone-induced catecholamine production by bone morphogenetic protein-4 through activating Rho and SAPK/JNK pathway in adrenomedullar cells. Catecholamines 35-48 mitogen-activated protein kinase 9 Rattus norvegicus 124-127 19340353-0 2009 Angiotensin converting enzyme-regulated, noncholinergic sympathoadrenal catecholamine release mediates the cardiovascular actions of human "new pressor protein" related to coagulation beta-factor XIIa. Catecholamines 72-85 angiotensin I converting enzyme Rattus norvegicus 0-29 19171676-6 2009 SULT1A1 is known to catalyze the metabolism of small phenols, whereas SULT1A3 sulfates catecholamine neurotransmitters. Catecholamines 87-100 sulfotransferase family 1A member 1 Homo sapiens 0-7 19171676-6 2009 SULT1A1 is known to catalyze the metabolism of small phenols, whereas SULT1A3 sulfates catecholamine neurotransmitters. Catecholamines 87-100 sulfotransferase family 1A member 3 Homo sapiens 70-77 19190257-15 2009 Collectively, our findings demonstrate that aldosterone stimulates catecholamine biosynthesis in adrenomedullar cells via MR through genomic action and partly through nongenomic action by Rho-SAPK/JNK signaling, the latter of which is facilitated by BMP-4. Catecholamines 67-80 nuclear receptor subfamily 3, group C, member 2 Rattus norvegicus 122-124 19190257-16 2009 A functional link between MR actions and endogenous BMP may be involved in the catecholamine production. Catecholamines 79-92 nuclear receptor subfamily 3, group C, member 2 Rattus norvegicus 26-28 18982411-9 2009 The failure of lactoferrin to provide higher protection seems to be associated with the complexity of catecholamine cardiotoxicity and with its hydrophilic character. Catecholamines 102-115 lactotransferrin Rattus norvegicus 15-26 19340353-10 2009 CONCLUSIONS: The cardiovascular effects of NPP/beta-FXIIa are considerably mediated by a noncholinergic (peptidergic) ACE-regulated mechanism for sympathoadrenal catecholamine release that is enhanced by +GB and/or +CAP. Catecholamines 162-175 angiotensin I converting enzyme Homo sapiens 118-121 19221126-9 2009 Furthermore it would appear that increases in circulating catecholamine levels may be one potential mechanism mediating exercise induced increases in PGC-1alpha mRNA expression in rat abdominal adipose tissue. Catecholamines 58-71 PPARG coactivator 1 alpha Rattus norvegicus 150-160 18297236-8 2009 The results demonstrate increased catecholamine metabolism via elevated catechol-O-methyl transferase activity during intermittent sprinting. Catecholamines 34-47 catechol-O-methyltransferase Homo sapiens 72-101 19207826-6 2009 IFN-alpha mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis. Catecholamines 154-167 interferon alpha-A Bos taurus 0-9 19207826-6 2009 IFN-alpha mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis. Catecholamines 154-167 mitogen-activated protein kinase 3 Bos taurus 33-39 18989660-2 2009 The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 28-42 catechol-O-methyltransferase Homo sapiens 4-8 18989660-2 2009 The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Catecholamines 28-42 catechol-O-methyltransferase Homo sapiens 52-56 19324274-3 2009 In competition, some other cell types are able to take up catecholamines and related compounds probably by organic cation (OCT) [extraneuronal monoamine (EMT)] transporters (OCT1, OCT2, OCT3=EMT). Catecholamines 58-72 IL2 inducible T cell kinase Homo sapiens 154-157 19324274-3 2009 In competition, some other cell types are able to take up catecholamines and related compounds probably by organic cation (OCT) [extraneuronal monoamine (EMT)] transporters (OCT1, OCT2, OCT3=EMT). Catecholamines 58-72 solute carrier family 22 member 1 Homo sapiens 174-178 19324274-3 2009 In competition, some other cell types are able to take up catecholamines and related compounds probably by organic cation (OCT) [extraneuronal monoamine (EMT)] transporters (OCT1, OCT2, OCT3=EMT). Catecholamines 58-72 POU class 2 homeobox 2 Homo sapiens 180-184 19324274-3 2009 In competition, some other cell types are able to take up catecholamines and related compounds probably by organic cation (OCT) [extraneuronal monoamine (EMT)] transporters (OCT1, OCT2, OCT3=EMT). Catecholamines 58-72 solute carrier family 22 member 3 Homo sapiens 186-190 19324274-3 2009 In competition, some other cell types are able to take up catecholamines and related compounds probably by organic cation (OCT) [extraneuronal monoamine (EMT)] transporters (OCT1, OCT2, OCT3=EMT). Catecholamines 58-72 IL2 inducible T cell kinase Homo sapiens 191-194 19291302-1 2009 BACKGROUND: Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 76-90 catechol-O-methyltransferase Homo sapiens 12-40 19291302-1 2009 BACKGROUND: Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 76-90 catechol-O-methyltransferase Homo sapiens 42-46 19234472-5 2009 We independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression. Catecholamines 67-81 Catecholamines up Drosophila melanogaster 59-65 19234499-4 2009 Experimental evidence indicates that the expression of IL-18 and/or its receptor can be induced by catecholamines or angiotensin, two factors that are involved in the pathophysiology of hypertension. Catecholamines 99-113 interleukin 18 Homo sapiens 55-60 18444787-7 2009 Thus, catecholamine/p38/MAPK is identified as a key signal transduction pathway in HPCs besides those dependent on Wnt, Notch, and sonic hedgehog. Catecholamines 6-19 mitogen-activated protein kinase 14 Mus musculus 20-23 19019914-9 2009 Renal tyrosine hydroxylase mRNA and immunoreactivity were reduced in IA-2/IA-2beta-/- mice as was the urinary excretion of catecholamines. Catecholamines 123-137 histocompatibility 2, class II antigen A, beta 1 Mus musculus 69-73 19019914-10 2009 We conclude that IA-2 and IA-2beta are required to maintain normal levels of renin expression and renin release, most likely by permitting normal rates of catecholamine release from sympathetic nerve terminals. Catecholamines 155-168 histocompatibility 2, class II antigen A, beta 1 Mus musculus 17-21 19019914-10 2009 We conclude that IA-2 and IA-2beta are required to maintain normal levels of renin expression and renin release, most likely by permitting normal rates of catecholamine release from sympathetic nerve terminals. Catecholamines 155-168 protein tyrosine phosphatase, receptor type, N polypeptide 2 Mus musculus 26-34 19016678-1 2009 The beta-2 adrenergic receptor (AR) mediates metabolic actions of catecholamines, including glycogenolysis, lipolysis and proteolysis, in muscle and adipose tissue. Catecholamines 66-80 adrenoceptor beta 2 Sus scrofa 4-30 18982239-1 2009 Dopamine-beta-hydroxylase (DbetaH) catalyzes the conversion of dopamine to norepinephrine in central noradrenergic and adrenergic neurons and thus is critically involved in the biosynthesis of catecholamines. Catecholamines 193-207 dopamine beta-hydroxylase Homo sapiens 0-25 18841392-1 2009 Catecholamines (CA) play an important role in the regulation of GnRH neurons in adults, and it is probable that they control GnRH-neuron development. Catecholamines 0-14 gonadotropin releasing hormone 1 Rattus norvegicus 64-68 18841392-1 2009 Catecholamines (CA) play an important role in the regulation of GnRH neurons in adults, and it is probable that they control GnRH-neuron development. Catecholamines 0-14 gonadotropin releasing hormone 1 Rattus norvegicus 125-129 18841392-10 2009 In conclusion, these data suggest that endogenous catecholamines stimulate the GnRH neuron migration in ontogenesis. Catecholamines 50-64 gonadotropin releasing hormone 1 Rattus norvegicus 79-83 18955128-3 2009 Given the significance of this interaction to atherogenesis, we examined the effects of stress, operationalized as the arousal of negative affect (NA) and cardiovascular and catecholamine responses to the Anger Recall Interview (ARI), on the expression of LFA-1 (CD11a), Mac-1 (CD11b) and p150/95 (CD11c) on circulating monocytes (CD14+). Catecholamines 174-187 integrin subunit alpha L Homo sapiens 256-261 17920711-5 2009 We present a biologically plausible explanation as to why VEGF antagonism may have an important role through its modulation of nitric oxide and catecholamine effects. Catecholamines 144-157 vascular endothelial growth factor A Homo sapiens 58-62 19129404-0 2009 Simultaneous silencing of Npy and Dbh expression in hindbrain A1/C1 catecholamine cells suppresses glucoprivic feeding. Catecholamines 68-81 neuropeptide Y Homo sapiens 26-29 19008227-2 2009 CAPS1 appears to have an additional and as yet unexplained function in vesicular catecholamine uptake or storage as CAPS1-deficient chromaffin cells exhibit strongly reduced vesicular catecholamine levels. Catecholamines 81-94 Ca2+-dependent secretion activator Mus musculus 0-5 19008227-2 2009 CAPS1 appears to have an additional and as yet unexplained function in vesicular catecholamine uptake or storage as CAPS1-deficient chromaffin cells exhibit strongly reduced vesicular catecholamine levels. Catecholamines 184-197 Ca2+-dependent secretion activator Mus musculus 0-5 18955037-0 2009 Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brain. Catecholamines 86-100 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 34-37 19129404-0 2009 Simultaneous silencing of Npy and Dbh expression in hindbrain A1/C1 catecholamine cells suppresses glucoprivic feeding. Catecholamines 68-81 dopamine beta-hydroxylase Homo sapiens 34-37 19129404-2 2009 Catecholamine/NPY cell bodies are concentrated in the A1 and caudal C1 cell cluster (A1/C1) in the ventrolateral medulla, a region highly sensitive to glucoprivic challenge. Catecholamines 0-13 neuropeptide Y Homo sapiens 14-17 19129404-3 2009 To further investigate the importance of this catecholamine subpopulation in glucoregulation, we used small interfering RNA (siRNA) technology to produce a targeted gene knockdown of NPY and dopamine-beta-hydroxylase (DBH), a catecholamine biosynthetic enzyme. Catecholamines 46-59 neuropeptide Y Homo sapiens 183-186 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Catecholamines 49-63 catechol-O-methyltransferase Homo sapiens 0-29 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Catecholamines 49-63 catechol-O-methyltransferase Homo sapiens 31-35 18955435-2 2009 Catecholamines are major hormones that govern lipolysis through elevating cellular cAMP production and activating protein kinase, cAMP dependent, catalytic, alpha (PKA) and mitogen-activated protein kinase 1/2 (MAPK1/3). Catecholamines 0-14 mitogen activated protein kinase 1 Rattus norvegicus 211-216 21637643-3 2009 Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. Catecholamines 39-53 catechol-O-methyltransferase Homo sapiens 85-89 18720287-1 2009 BACKGROUND: Chromogranin A (CGA), a stress marker released with catecholamines by the adrenal medulla, has never been associated with acute inflammation in critically ill patients. Catecholamines 64-78 chromogranin A Homo sapiens 12-26 18720287-1 2009 BACKGROUND: Chromogranin A (CGA), a stress marker released with catecholamines by the adrenal medulla, has never been associated with acute inflammation in critically ill patients. Catecholamines 64-78 chromogranin A Homo sapiens 28-31 19664189-1 2009 During advanced vasodilatory shock, arginine vasopressin (AVP) is increasingly used to restore blood pressure and thus to reduce catecholamine requirements. Catecholamines 129-142 arginine vasopressin Homo sapiens 45-56 19546095-11 2009 CONCLUSION: It is assumed that the alterations in the concentration of catecholamines and their metabolites in the BAC-exposed rats were related to the unexpectedly strong and persistent activation of the hypothalamo-pituitary-adrenocortical (HPA) axis evidenced by the high plasma CORT concentration. Catecholamines 71-85 cortistatin Rattus norvegicus 282-286 19109190-7 2009 We also show that beta-adrenergic receptor activation by catecholamine of macrophages mediates the HS/R-induced release of HMGB1. Catecholamines 57-70 high mobility group box 1 Homo sapiens 123-128 19476053-5 2009 Activation of the neuroendocrine and sympathetic systems through catecholamine and cortisol secretion exerts an influence upon the immune system, modifying the balance between Th1/Th2 response in favor of Th2 action. Catecholamines 65-78 negative elongation factor complex member C/D Homo sapiens 176-179 19296409-1 2009 Associations were evaluated between a functional single nucleotide polymorphism (Val158Met) in the gene encoding the catecholamine catabolic enzyme catechol O-methyltransferase (COMT), dental mercury exposure, and self-reported symptoms and mood among 183 male dentists and 213 female dental assistants. Catecholamines 117-130 catechol-O-methyltransferase Homo sapiens 148-176 19296409-1 2009 Associations were evaluated between a functional single nucleotide polymorphism (Val158Met) in the gene encoding the catecholamine catabolic enzyme catechol O-methyltransferase (COMT), dental mercury exposure, and self-reported symptoms and mood among 183 male dentists and 213 female dental assistants. Catecholamines 117-130 catechol-O-methyltransferase Homo sapiens 178-182 18834926-4 2008 We used immunoquantification associated to densitometry to evaluate the amount of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, in the key organs of the chemoafferent and sympathoadrenergic pathways: the carotid body (CB), the petrosal ganglion (PG), the superior cervical ganglion (SCG) and the adrenal medulla (AM). Catecholamines 132-145 tyrosine hydroxylase Mus musculus 82-102 19212441-3 2009 Phagocytes isolated from adrenalectomized rats displayed enhanced expression of tyrosine-hydroxylase and dopamine-beta-hydroxylase, two key enzymes for catecholamine production and exhibited higher baseline secretion of norepinephrine and epinephrine. Catecholamines 152-165 dopamine beta-hydroxylase Rattus norvegicus 105-130 19212441-5 2009 Increased levels of phagocyte-derived catecholamines were associated with intensification of the acute inflammatory response, as assessed by increased plasma leak of albumin, enhanced myeloperoxidase content in lungs, augmented levels of proinflammatory mediators in bronchoalveolar lavage fluids, and elevated expression of pulmonary ICAM-1 and VCAM-1. Catecholamines 38-52 myeloperoxidase Rattus norvegicus 184-199 19212441-5 2009 Increased levels of phagocyte-derived catecholamines were associated with intensification of the acute inflammatory response, as assessed by increased plasma leak of albumin, enhanced myeloperoxidase content in lungs, augmented levels of proinflammatory mediators in bronchoalveolar lavage fluids, and elevated expression of pulmonary ICAM-1 and VCAM-1. Catecholamines 38-52 intercellular adhesion molecule 1 Rattus norvegicus 335-341 19212441-5 2009 Increased levels of phagocyte-derived catecholamines were associated with intensification of the acute inflammatory response, as assessed by increased plasma leak of albumin, enhanced myeloperoxidase content in lungs, augmented levels of proinflammatory mediators in bronchoalveolar lavage fluids, and elevated expression of pulmonary ICAM-1 and VCAM-1. Catecholamines 38-52 vascular cell adhesion molecule 1 Rattus norvegicus 346-352 18824087-2 2008 HSL enzymatic activity is increased by adrenergic agonists, such as catecholamines and glucagons, which induce cyclic AMP (cAMP) intracellular production, subsequently followed by the activation of Protein Kinase A (PKA) and its downstream signaling cascade reactions. Catecholamines 68-82 lipase E, hormone sensitive type Homo sapiens 0-3 19094200-2 2008 Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 88-116 19094200-2 2008 Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 118-122 19225567-1 2009 BACKGROUND: Antimicrobial peptides derived from the natural processing of chromogranin A (CgA) are co-secreted with catecholamines upon stimulation of chromaffin cells. Catecholamines 116-130 chromogranin A Homo sapiens 74-88 19225567-1 2009 BACKGROUND: Antimicrobial peptides derived from the natural processing of chromogranin A (CgA) are co-secreted with catecholamines upon stimulation of chromaffin cells. Catecholamines 116-130 chromogranin A Homo sapiens 90-93 18752792-13 2008 In conclusion, this case report of MEN 2A linked to a 634 RET mutation was peculiar by its revelation mode (1) hyperparathyroidism moreover linked to an adenoma and (2) associated with diabetes, mechanisms of which are probably multifactorial (familial type 2 diabetes, hypercalcemia, catecholamines excess). Catecholamines 285-299 ret proto-oncogene Homo sapiens 35-41 19120093-2 2008 The present study investigated gene expression of catecholamines (CA)-synthesizing enzymes and protein levels, especially of tyrosine hydroxylase (TH), in response to acute (120 min) and repeated (7 x 120 min) immobilization (IMO) stress. Catecholamines 50-64 tyrosine hydroxylase Rattus norvegicus 125-145 19120093-2 2008 The present study investigated gene expression of catecholamines (CA)-synthesizing enzymes and protein levels, especially of tyrosine hydroxylase (TH), in response to acute (120 min) and repeated (7 x 120 min) immobilization (IMO) stress. Catecholamines 50-64 tyrosine hydroxylase Rattus norvegicus 147-149 19120100-1 2008 Peripheral administration of lipopolysaccharide (LPS) in an amount that produces acute stress has been found to affect the catecholamine systems in the brain. Catecholamines 123-136 toll-like receptor 4 Mus musculus 49-52 19120100-5 2008 LPS injection on catecholamine biosynthesis in the OB and AON in 8-week-old C3H/HeN male mice. Catecholamines 17-30 toll-like receptor 4 Mus musculus 0-3 19120118-0 2008 Regulation of gene expression of catecholamine biosynthetic enzymes in dopamine-beta-hydroxylase- and CRH-knockout mice exposed to stress. Catecholamines 33-46 dopamine beta hydroxylase Mus musculus 71-96 19120118-0 2008 Regulation of gene expression of catecholamine biosynthetic enzymes in dopamine-beta-hydroxylase- and CRH-knockout mice exposed to stress. Catecholamines 33-46 corticotropin releasing hormone Mus musculus 102-105 18541522-1 2008 Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide that is formed endogenously by proteolytic cleavage of its precursor chromogranin A, a major protein co-stored and co-released with catecholamines from the storage vesicles in adrenal chromaffin cells and adrenergic neurons. Catecholamines 204-218 chromogranin A Homo sapiens 0-10 18541522-1 2008 Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide that is formed endogenously by proteolytic cleavage of its precursor chromogranin A, a major protein co-stored and co-released with catecholamines from the storage vesicles in adrenal chromaffin cells and adrenergic neurons. Catecholamines 204-218 chromogranin A Homo sapiens 141-155 18541522-6 2008 These hypotensive actions of catestatin may be caused directly by autocrine inhibition of catecholamine release from the sympathoadrenal system and indirectly by paracrine stimulation of the potent vasodilator histamine release from mast cells. Catecholamines 90-103 chromogranin A Homo sapiens 29-39 18541522-7 2008 Recently, three human variants of catestatin displaying differential potencies for inhibition of catecholamine secretion have been identified. Catecholamines 97-110 chromogranin A Homo sapiens 34-44 19120125-8 2008 A targeted KO of tyrosine hydroxylase in PNMT-producing cells produced a mouse deficient in catecholamines in the adrenal. Catecholamines 92-106 phenylethanolamine-N-methyltransferase Mus musculus 41-45 18689792-0 2008 Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Catecholamines 58-71 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 12-23 18689792-8 2008 Notably, I-1-KO were partially protected from lethal catecholamine-induced arrhythmias and from hypertrophy and dilation induced by a 7 day infusion with the beta-adrenergic agonist isoprenaline. Catecholamines 53-66 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 9-12 18689792-12 2008 CONCLUSION: Taken together, loss of I-1 attenuates detrimental effects of catecholamines on the heart, suggesting I-1 downregulation in heart failure as a beneficial desensitization mechanism and I-1 inhibition as a potential novel strategy for heart failure treatment. Catecholamines 74-88 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 36-39 18689792-12 2008 CONCLUSION: Taken together, loss of I-1 attenuates detrimental effects of catecholamines on the heart, suggesting I-1 downregulation in heart failure as a beneficial desensitization mechanism and I-1 inhibition as a potential novel strategy for heart failure treatment. Catecholamines 74-88 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 114-117 18689792-12 2008 CONCLUSION: Taken together, loss of I-1 attenuates detrimental effects of catecholamines on the heart, suggesting I-1 downregulation in heart failure as a beneficial desensitization mechanism and I-1 inhibition as a potential novel strategy for heart failure treatment. Catecholamines 74-88 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 114-117 18752792-13 2008 In conclusion, this case report of MEN 2A linked to a 634 RET mutation was peculiar by its revelation mode (1) hyperparathyroidism moreover linked to an adenoma and (2) associated with diabetes, mechanisms of which are probably multifactorial (familial type 2 diabetes, hypercalcemia, catecholamines excess). Catecholamines 285-299 ret proto-oncogene Homo sapiens 58-61 18840642-12 2008 CONCLUSIONS: Patients with SDHB mutations may present with biochemically silent abdominal PGLs due to defective catecholamine synthesis resulting from the absence of tyrosine hydroxylase. Catecholamines 112-125 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 27-31 19049483-0 2008 Monitoring of brain tissue oxygen tension and use of vasopressin after cardiac arrest in a child with catecholamine-induced cardiac arrhythmia. Catecholamines 102-115 arginine vasopressin Homo sapiens 53-64 18824168-0 2008 Therapy with interferon-beta modulates endogenous catecholamines in lymphocytes of patients with multiple sclerosis. Catecholamines 50-64 interferon beta 1 Homo sapiens 13-28 18840642-13 2008 Screening for tumors in patients with SDHB mutations should not be limited to biochemical tests of catecholamine excess. Catecholamines 99-112 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 38-42 18772317-1 2008 Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations. Catecholamines 103-117 adrenoceptor beta 2 Homo sapiens 41-61 18772317-13 2008 In conclusion, our data with betaAR-G(s)alpha fusion proteins show that endogenous catecholamines and ISO stabilize distinct conformations in the beta(1)AR and beta(2)AR. Catecholamines 83-97 adrenoceptor beta 1 Homo sapiens 146-155 18772317-1 2008 Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations. Catecholamines 103-117 adrenoceptor beta 2 Homo sapiens 63-72 18772317-13 2008 In conclusion, our data with betaAR-G(s)alpha fusion proteins show that endogenous catecholamines and ISO stabilize distinct conformations in the beta(1)AR and beta(2)AR. Catecholamines 83-97 adrenoceptor beta 2 Homo sapiens 160-169 18682257-2 2008 Fibroblast growth factor 2 (FGF2) is a growth factor essential for the proper formation of synaptic connections in the cerebral cortex, maturation and survival of catecholamine neurons, and neurogenesis. Catecholamines 163-176 fibroblast growth factor 2 Rattus norvegicus 0-26 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 tyrosine hydroxylase Rattus norvegicus 129-149 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 tyrosine hydroxylase Rattus norvegicus 151-153 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 dopamine beta-hydroxylase Rattus norvegicus 156-181 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 dopamine beta-hydroxylase Rattus norvegicus 183-186 18682257-2 2008 Fibroblast growth factor 2 (FGF2) is a growth factor essential for the proper formation of synaptic connections in the cerebral cortex, maturation and survival of catecholamine neurons, and neurogenesis. Catecholamines 163-176 fibroblast growth factor 2 Rattus norvegicus 28-32 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 phenylethanolamine-N-methyltransferase Rattus norvegicus 192-230 19112418-2 2008 The aim of this work was to investigate the changes in gene expression and protein levels of catecholamine biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in the adrenal medulla of naive control and chronically (12 weeks) socially isolated adult Wistar rat males and the response of these animals to additional immobilization stress (2 h). Catecholamines 93-106 phenylethanolamine-N-methyltransferase Rattus norvegicus 232-236 18704099-2 2008 The catechol-O-methyltransferase (COMT) is involved in the degradation of catecholamines and a functional polymorphism (Val158Met) has been suggested to influence enzyme activity. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 4-32 19112418-11 2008 The results indicate a possible adaptation of catecholamine-synthesizing system at the level of TH gene expression in adrenal medulla of chronically isolated animals. Catecholamines 46-59 tyrosine hydroxylase Rattus norvegicus 96-98 18704099-2 2008 The catechol-O-methyltransferase (COMT) is involved in the degradation of catecholamines and a functional polymorphism (Val158Met) has been suggested to influence enzyme activity. Catecholamines 74-88 catechol-O-methyltransferase Homo sapiens 34-38 18801628-2 2008 Polymorphic variants of genes encoding key enzymes of folate and methionine metabolism may have an impact on catecholamine catabolism conducted by catechol-O-methyltransferase. Catecholamines 109-122 catechol-O-methyltransferase Homo sapiens 147-175 18722481-3 2008 Targeted ablation of the Chga gene resulted in increased plasma catecholamines, high blood pressure, and decreased size and number of adrenal medullary chromaffin granules. Catecholamines 64-78 chromogranin A Mus musculus 25-29 18675312-2 2008 This effect is mainly mediated via catecholamines, which signal through elevation of Ca(i)(2+) as well as cAMP. Catecholamines 35-49 cathelicidin antimicrobial peptide Homo sapiens 106-110 18834877-3 2008 We therefore hypothesized that the catecholamine release inhibitory peptide catestatin (hCgA(352-372)) would induce directed monocyte migration. Catecholamines 35-48 chromogranin A Homo sapiens 76-86 18715275-9 2008 The neuropeptide Y (NPY) promoter C-1450T genotype is also suggested to be involved in the individual differences in regulation of catecholamine secretion. Catecholamines 131-144 neuropeptide Y Homo sapiens 4-18 18715275-9 2008 The neuropeptide Y (NPY) promoter C-1450T genotype is also suggested to be involved in the individual differences in regulation of catecholamine secretion. Catecholamines 131-144 neuropeptide Y Homo sapiens 20-23 18814973-13 2008 CONCLUSIONS: These data demonstrate that hypoglycemia-associated social withdrawal is dependent on catecholamines via a beta-2 receptor-mediated pathway. Catecholamines 99-113 hemoglobin, beta adult minor chain Mus musculus 120-126 19076364-4 2008 When generated by the hypothalamus in response to inflammation or other stresses, CRH is immunosuppressive through its ability to increase levels of glucocorticoids and catecholamines. Catecholamines 169-183 corticotropin releasing hormone Homo sapiens 82-85 18754761-1 2008 Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare inborn error of neurotransmitter biosynthesis that leads to a combined deficiency of catecholamines and serotonin and is characterized by global developmental delay, involuntary movements, and autonomic dysfunction. Catecholamines 149-163 dopa decarboxylase Homo sapiens 0-35 18754761-1 2008 Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare inborn error of neurotransmitter biosynthesis that leads to a combined deficiency of catecholamines and serotonin and is characterized by global developmental delay, involuntary movements, and autonomic dysfunction. Catecholamines 149-163 dopa decarboxylase Homo sapiens 37-41 18854424-5 2008 The rate constant for baseline catecholamine secretion was 20-fold higher in VHL than in MEN 2 tumors (0.359 +/- 0.094 vs. 0.018 +/- 0.009 day(-1)), but catecholamine release was responsive only to glucagon in MEN 2 tumors. Catecholamines 31-44 von Hippel-Lindau tumor suppressor Homo sapiens 77-80 18854424-5 2008 The rate constant for baseline catecholamine secretion was 20-fold higher in VHL than in MEN 2 tumors (0.359 +/- 0.094 vs. 0.018 +/- 0.009 day(-1)), but catecholamine release was responsive only to glucagon in MEN 2 tumors. Catecholamines 153-166 von Hippel-Lindau tumor suppressor Homo sapiens 77-80 18635652-2 2008 We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Catecholamines 101-115 regulator of G-protein signaling 4 Mus musculus 33-73 18635652-4 2008 We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. Catecholamines 105-119 regulator of G-protein signaling 4 Mus musculus 27-31 18635652-5 2008 RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. Catecholamines 119-132 regulator of G-protein signaling 4 Mus musculus 0-4 18981694-1 2008 Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Rattus norvegicus 162-190 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 tyrosine hydroxylase Rattus norvegicus 198-218 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 tyrosine hydroxylase Rattus norvegicus 220-222 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 dopamine beta-hydroxylase Rattus norvegicus 225-250 19227810-4 2008 Adiponectin secretion is inhibited by TNF-alpha and by catecholamines, and is stimulated by PPAR gamma activation. Catecholamines 55-69 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 19010176-1 2008 INTRODUCTION: Prolonged catecholamine overstimulation of the myocardium in chronic heart failure causes a reduction in the number and functionality of beta1-adrenoceptors (beta1-AR) of the heart. Catecholamines 24-37 adrenoceptor beta 1 Homo sapiens 151-170 19010176-1 2008 INTRODUCTION: Prolonged catecholamine overstimulation of the myocardium in chronic heart failure causes a reduction in the number and functionality of beta1-adrenoceptors (beta1-AR) of the heart. Catecholamines 24-37 adrenoceptor beta 1 Homo sapiens 172-180 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 dopamine beta-hydroxylase Rattus norvegicus 252-255 18981694-1 2008 Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Rattus norvegicus 192-196 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 phenylethanolamine-N-methyltransferase Rattus norvegicus 261-299 18981694-3 2008 Using the developed method, we have found that inactivation of catecholamines by COMT is attenuated in hypertensive rats compared to normotensive rats. Catecholamines 63-77 catechol-O-methyltransferase Rattus norvegicus 81-85 18987458-6 2008 Real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mRNAs for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 115-128 phenylethanolamine-N-methyltransferase Rattus norvegicus 301-305 18951085-1 2008 Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy. Catecholamines 9-23 E74 like ETS transcription factor 4 Homo sapiens 77-100 19017515-2 2008 BACKGROUND: CHGA regulates catecholamine storage and release. Catecholamines 27-40 chromogranin A Homo sapiens 12-16 19017515-6 2008 RESULTS: CHGA was overexpressed in patients with hypertension, especially hypertensive men, and CHGA predicted catecholamines. Catecholamines 111-125 chromogranin A Homo sapiens 9-13 19017515-6 2008 RESULTS: CHGA was overexpressed in patients with hypertension, especially hypertensive men, and CHGA predicted catecholamines. Catecholamines 111-125 chromogranin A Homo sapiens 96-100 19017515-11 2008 In cultured chromaffin cells, reducing endogenous CHGA expression by small interfering ribonucleic acid caused approximately two-thirds depletion of catecholamine storage vesicles. Catecholamines 149-162 chromogranin A Homo sapiens 50-54 18951085-1 2008 Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as pathological myocardial hypertrophy. Catecholamines 9-23 E74 like ETS transcription factor 4 Homo sapiens 102-105 18973576-11 2008 These data demonstrate differential distribution of VMAT2 within different subpopulations of C1 neurons and suggest that this might reflect differences in somatodendritic vs. synaptic release of catecholamines. Catecholamines 195-209 solute carrier family 18 member A2 Rattus norvegicus 52-57 18674612-9 2008 These results suggest that TRP-2 acts on quinone metabolites other than DOPAchrome, e.g., in the catecholamine pathway, and limits their deleterious effects. Catecholamines 97-110 dopachrome tautomerase Homo sapiens 27-32 18540901-3 2008 As resorption of foetal lung fluid is a catecholamine dependent process, we aimed at investigating, whether beta1- and beta2-adrenoreceptor (ADRB1, ADRB2) polymorphisms, known to alter catecholamine activity, are operative in TTN. Catecholamines 185-198 adrenoceptor beta 1 Homo sapiens 108-139 18540901-3 2008 As resorption of foetal lung fluid is a catecholamine dependent process, we aimed at investigating, whether beta1- and beta2-adrenoreceptor (ADRB1, ADRB2) polymorphisms, known to alter catecholamine activity, are operative in TTN. Catecholamines 185-198 adrenoceptor beta 1 Homo sapiens 141-146 18275991-6 2008 For example dysregulation of the catecholamine system could alter catechol-O-methyltransferase-catalyzed methylation, preventing removal of redox cycling catecholestrogens from the system enhancing pro-oxidant effects of estradiol. Catecholamines 33-46 catechol-O-methyltransferase Homo sapiens 66-94 27688562-0 2008 Effects of Low Dose Vasopressin in Catecholamine Resistant Septic Shock. Catecholamines 35-48 arginine vasopressin Homo sapiens 20-31 27688562-12 2008 CONCLUSION: Low dose vasopressin at the rate of 0.04 unit/minute is an effective vasopressor in adult patients with catecholamine resistant septic shock. Catecholamines 116-129 arginine vasopressin Homo sapiens 21-32 18647601-5 2008 administered neuromedin U on plasma catecholamines with regard to the brain prostanoid using anesthetized rats. Catecholamines 36-50 neuromedin U Rattus norvegicus 13-25 18674600-2 2008 Likewise, a large subpopulation of cholinergic neurons of the mouse heart expresses enzymes needed for synthesis of norepinephrine (NE), but they lack the vesicular monoamine transporter type 2 (VMAT2) required for catecholamine storage. Catecholamines 215-228 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 155-193 18674600-2 2008 Likewise, a large subpopulation of cholinergic neurons of the mouse heart expresses enzymes needed for synthesis of norepinephrine (NE), but they lack the vesicular monoamine transporter type 2 (VMAT2) required for catecholamine storage. Catecholamines 215-228 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 195-200 18674600-6 2008 Dopamine beta-hydroxylase (DBH) and norepinephrine transporter (NET) were present in all cholinergic somata, indicating a wider capability for dopamine metabolism and catecholamine uptake. Catecholamines 167-180 dopamine beta hydroxylase Mus musculus 0-25 18794526-4 2008 COMT2 enzymatic activity is significantly reduced by the missense mutation, suggesting that a defect in catecholamine catabolism underlies the auditory and vestibular phenotypes. Catecholamines 104-117 transmembrane O-methyltransferase Mus musculus 0-5 18794526-6 2008 Defects in catecholamine modification by COMT have been previously implicated in the development of schizophrenia. Catecholamines 11-24 catechol-O-methyltransferase Mus musculus 41-45 18794526-7 2008 Our studies identify a previously undescribed COMT gene and indicate an unexpected role for catecholamines in the function of auditory and vestibular sense organs. Catecholamines 92-106 catechol-O-methyltransferase Mus musculus 46-50 18619478-3 2008 To address this possibility, relationships between immunolabeled tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine synthesis) and song produced within versus outside of a breeding context were explored in male European starlings (Sturnus vulgaris). Catecholamines 119-132 tyrosine 3-monooxygenase Sturnus vulgaris 65-85 18594791-12 2008 CONCLUSIONS/INTERPRETATION: Our results show that Il1ra (-/-) mice have increased energy expenditure, fat:carbohydrate oxidation ratio, body temperature, heart rate and catecholamine production. Catecholamines 169-182 interleukin 1 receptor antagonist Mus musculus 50-55 18208403-1 2008 The TH (tyrosine hydroxylase) gene encodes the rate-limiting enzyme of catecholamine biosynthesis, and is involved in the pathogenesis of hypertension, but the relationship of its variants with hypertension has not been extensively studied. Catecholamines 71-84 tyrosine hydroxylase Homo sapiens 8-28 18635750-2 2008 The acute response to stress causes the release of catecholamines from the adrenal medulla accompanied by chromogranin A (CGA). Catecholamines 51-65 chromogranin A Homo sapiens 106-120 18635750-2 2008 The acute response to stress causes the release of catecholamines from the adrenal medulla accompanied by chromogranin A (CGA). Catecholamines 51-65 chromogranin A Homo sapiens 122-125 18687199-1 2008 Arginine vasopressin and terlipressin increase mean arterial pressure and reduce catecholamine requirements in septic shock patients. Catecholamines 81-94 arginine vasopressin Homo sapiens 9-20 18783367-4 2008 mRNA for enzymes in dorsal root ganglia involved in catecholamine uptake and metabolism, dopamine beta-hydroxylase and MAO-A, were decreased by neonatal administration of capsaicin. Catecholamines 52-65 dopamine beta-hydroxylase Rattus norvegicus 89-114 18703939-2 2008 The catechol-O-methyltransferase (COMT) enzyme degrades synaptic catecholamines and plays a specific role in the catabolism of prefrontal cortex dopamine. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 4-32 18703939-2 2008 The catechol-O-methyltransferase (COMT) enzyme degrades synaptic catecholamines and plays a specific role in the catabolism of prefrontal cortex dopamine. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 34-38 18783367-6 2008 Finally, intradermal injection of 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), a neurotoxic MAO-A catecholamine metabolite, produced robust mechanical hyperalgesia. Catecholamines 98-111 monoamine oxidase A Rattus norvegicus 92-97 18783367-7 2008 These observations suggest that catecholamines in nociceptors are metabolized to neurotoxic products by MAO-A, which can cause neuronal dysfunction underlying neuropathic pain. Catecholamines 32-46 monoamine oxidase A Rattus norvegicus 104-109 18499710-4 2008 MAOA has been shown to catabolize catecholamines that were reported to regulate luteal function in CL and vasoconstriction in various organs. Catecholamines 34-48 monoamine oxidase A Homo sapiens 0-4 18469084-1 2008 Cardiac calsequestrin (CASQ2) is an intrasarcoplasmic reticulum (SR) low-affinity Ca-binding protein, with mutations that are associated with catecholamine-induced polymorphic ventricular tachycardia (CPVT). Catecholamines 142-155 calsequestrin 2 Canis lupus familiaris 0-21 18830525-0 2008 Vasopressin for the management of catecholamine-resistant anaphylactic shock. Catecholamines 34-47 arginine vasopressin Homo sapiens 0-11 18669662-8 2008 Surgical ablation of the splenic nerve and catecholamine depletion by reserpine indicate that these nerves are catecholaminergic and are required for functional inhibition of TNF production by vagus nerve stimulation. Catecholamines 43-56 tumor necrosis factor Homo sapiens 175-178 18572378-4 2008 As it had previously been shown that the catecholamine system is responsive to ELF-EMF, and as this has also been linked to various pathologies and to certain types of cancer, we wondered whether exposure to this type of radiation could affect the expression of PHOX2A, PHOX2B and DbetaH, also during differentiation triggered by retinoic acid. Catecholamines 41-54 paired like homeobox 2A Homo sapiens 262-268 18579530-3 2008 We also solved the crystal structure of quinone reductase 2 in complexes with dopamine and adrenochrome, two compounds that are structurally related to catecholamine quinones. Catecholamines 152-165 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 40-59 18579530-5 2008 These results infer functional differences between two homologous enzymes and indicate that quinone reductase 2 could play important roles in the regulation of catecholamine oxidation processes that may be involved in the etiology of Parkinson disease. Catecholamines 160-173 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 92-111 18588939-9 2008 Indeed, malathion is known to inhibit AChE activity leads to subsequent activation of cholinergic receptor that increased in part, catecholamine and glucocorticoids secretion; provoked glycogenolysis and gluconeogenesis activation. Catecholamines 131-144 acetylcholinesterase Rattus norvegicus 38-42 18307051-5 2008 Increased MAO activity with correlated increase in lipid peroxidation in the aging rat brain supports the hypothesis that catecholamine oxidation is an important source of oxidative stress. Catecholamines 122-135 monoamine oxidase A Rattus norvegicus 10-13 18469084-1 2008 Cardiac calsequestrin (CASQ2) is an intrasarcoplasmic reticulum (SR) low-affinity Ca-binding protein, with mutations that are associated with catecholamine-induced polymorphic ventricular tachycardia (CPVT). Catecholamines 142-155 calsequestrin 2 Canis lupus familiaris 23-28 18505450-2 2008 The aim of the present study was to characterize the source of plasma catecholamines induced by centrally administered glucagon-like peptide-1 (GLP-1), with regard to brain prostanoids, in urethane-anaesthetized rats. Catecholamines 70-84 glucagon Rattus norvegicus 119-142 18593382-6 2008 Catecholamines and peptide hormones, such as AngII (angiotensin II), are elevated in hypertension and, therefore, signalling by these GPCRs is increased. Catecholamines 0-14 angiotensinogen Homo sapiens 45-50 18505450-2 2008 The aim of the present study was to characterize the source of plasma catecholamines induced by centrally administered glucagon-like peptide-1 (GLP-1), with regard to brain prostanoids, in urethane-anaesthetized rats. Catecholamines 70-84 glucagon Rattus norvegicus 144-149 18593382-6 2008 Catecholamines and peptide hormones, such as AngII (angiotensin II), are elevated in hypertension and, therefore, signalling by these GPCRs is increased. Catecholamines 0-14 angiotensinogen Homo sapiens 52-66 18505450-9 2008 The GLP-1-induced elevation of concentrations of both catecholamines was abolished by 1.2 micromol/animal indomethacin, an inhibitor of cyclo-oxygenase, whereas 1.2 micromol/animal baicalein, a lipoxygenase inhibitor, had no effect. Catecholamines 54-68 glucagon Rattus norvegicus 4-9 18513370-1 2008 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40). Catecholamines 79-93 tyrosine hydroxylase Homo sapiens 0-20 18522866-0 2008 Effect of age on angiotensin II-mediated downregulation of adrenomedullary catecholamine biosynthetic enzymes. Catecholamines 75-88 angiotensinogen Rattus norvegicus 17-31 18522866-5 2008 Neuropeptide Y (NPY), which is co-released with catecholamines in the adrenal medulla and stimulates the synthesis of TH and DbetaH, was also upregulated with age and downregulated in response to AngII in young rats. Catecholamines 48-62 neuropeptide Y Rattus norvegicus 0-14 18522866-5 2008 Neuropeptide Y (NPY), which is co-released with catecholamines in the adrenal medulla and stimulates the synthesis of TH and DbetaH, was also upregulated with age and downregulated in response to AngII in young rats. Catecholamines 48-62 neuropeptide Y Rattus norvegicus 16-19 18522866-7 2008 This data indicate that the hypertensive effect of peripheral AngII is compensated by an inhibition of adrenomedullary catecholamine biosynthesis in young animals, but this mechanism is impaired in senescence, potentially contributing to the age-related increase in catecholamine biosynthesis. Catecholamines 266-279 angiotensinogen Rattus norvegicus 62-67 18513370-1 2008 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40). Catecholamines 79-93 tyrosine hydroxylase Homo sapiens 22-24 18513370-1 2008 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40). Catecholamines 185-199 tyrosine hydroxylase Homo sapiens 0-20 18513370-1 2008 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40). Catecholamines 185-199 tyrosine hydroxylase Homo sapiens 22-24 18502539-5 2008 We can conclude that the central anorectic effects of GLP-1 agonists could be partially mediated by increased serotonin release in the hypothalamus, leaving the catecholamine release unaffected. Catecholamines 161-174 glucagon Rattus norvegicus 54-59 18534229-2 2008 TH01, a tetrameric short tandem repeat marker in the tyrosine hydroxylase gene, regulates gene expression and catecholamine production. Catecholamines 110-123 tyrosine hydroxylase Homo sapiens 53-73 18670203-9 2008 Decreased circulating vasopressin contributes to adrenal insufficiency via hypothalamic-pituitary-adrenal axis suppression and increased catecholamine resistance to vasopressors. Catecholamines 137-150 arginine vasopressin Homo sapiens 22-33 18561911-15 2008 Stimulation of adrenal medullary catecholamine release and subsequent activation of alpha(2)-adrenoceptors are mainly involved in the increase in plasma glucagon induced by choline, CDP-choline or phosphocholine. Catecholamines 33-46 cut-like homeobox 1 Rattus norvegicus 182-185 18591442-1 2008 BACKGROUND: Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragment inhibits catecholamine release. Catecholamines 43-56 chromogranin A Homo sapiens 12-26 18591442-1 2008 BACKGROUND: Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragment inhibits catecholamine release. Catecholamines 43-56 chromogranin A Homo sapiens 28-32 18591442-1 2008 BACKGROUND: Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragment inhibits catecholamine release. Catecholamines 124-137 chromogranin A Homo sapiens 95-105 18596155-6 2008 Comparing secretion during repeated stimulation between wild-type DOC2B and a mutated DOC2B that is constantly at the PM showed that DOC2B enhances catecholamine secretion also during repeated stimulation and that DOC2B has to translocate to the PM to exert its facilitating effect, suggesting that its activity is dependent on calcium. Catecholamines 148-161 double C2 domain beta Homo sapiens 86-91 18596155-6 2008 Comparing secretion during repeated stimulation between wild-type DOC2B and a mutated DOC2B that is constantly at the PM showed that DOC2B enhances catecholamine secretion also during repeated stimulation and that DOC2B has to translocate to the PM to exert its facilitating effect, suggesting that its activity is dependent on calcium. Catecholamines 148-161 double C2 domain beta Homo sapiens 86-91 18596155-6 2008 Comparing secretion during repeated stimulation between wild-type DOC2B and a mutated DOC2B that is constantly at the PM showed that DOC2B enhances catecholamine secretion also during repeated stimulation and that DOC2B has to translocate to the PM to exert its facilitating effect, suggesting that its activity is dependent on calcium. Catecholamines 148-161 double C2 domain beta Homo sapiens 86-91 18596155-8 2008 We conclude that DOC2B is a calcium-dependent priming factor and its activity at the PM enables efficient expansion of the fusion pore, leading to increased catecholamine release. Catecholamines 157-170 double C2 domain beta Homo sapiens 17-22 18356271-3 2008 Some sections were immunocytochemically labeled with the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), prior to the autoradiographic procedure. Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 92-112 18454940-1 2008 UNLABELLED: Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity. Catecholamines 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 18454940-1 2008 UNLABELLED: Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity. Catecholamines 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 18434255-5 2008 These results demonstrate that this catecholamine may inhibit vasopressin-stimulated water transport at a site prior to cAMP formation. Catecholamines 36-49 arginine vasopressin Homo sapiens 62-73 18419768-1 2008 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamine neurotransmitters. Catecholamines 74-87 tyrosine hydroxylase Homo sapiens 0-20 18419768-1 2008 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamine neurotransmitters. Catecholamines 74-87 tyrosine hydroxylase Homo sapiens 22-24 18432188-1 2008 Chromogranin A (CHGA) is stored and released from the same secretory vesicles that contain catecholamines in chromaffin cells and noradrenergic neurons. Catecholamines 91-105 chromogranin A Homo sapiens 16-20 18496412-7 2008 Observational studies have reported an improvement in blood pressure and rapid weaning off catecholamines during administration of low-dose vasopressin. Catecholamines 91-105 arginine vasopressin Homo sapiens 140-151 18432188-1 2008 Chromogranin A (CHGA) is stored and released from the same secretory vesicles that contain catecholamines in chromaffin cells and noradrenergic neurons. Catecholamines 91-105 chromogranin A Homo sapiens 0-14 18486144-1 2008 Catechol O-methyltransferase (COMT) plays important roles in the metabolism of catecholamine neurotransmitters and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 0-28 18639636-1 2008 ATP and neuropeptide Y (NPY) are examples of agents co-secreted with catecholamines from neuronal and neuroendocrine cells which may regulate the function of the cells from which they are released. Catecholamines 69-83 neuropeptide Y Homo sapiens 8-22 18639636-1 2008 ATP and neuropeptide Y (NPY) are examples of agents co-secreted with catecholamines from neuronal and neuroendocrine cells which may regulate the function of the cells from which they are released. Catecholamines 69-83 neuropeptide Y Homo sapiens 24-27 18639636-3 2008 The primary recognized function of chromaffin cells is the synthesis and secretion of catecholamines; therefore, we hypothesize that ATP and NPY can regulate catecholamine synthesis in chromaffin cells. Catecholamines 86-100 neuropeptide Y Homo sapiens 141-144 18639636-3 2008 The primary recognized function of chromaffin cells is the synthesis and secretion of catecholamines; therefore, we hypothesize that ATP and NPY can regulate catecholamine synthesis in chromaffin cells. Catecholamines 86-99 neuropeptide Y Homo sapiens 141-144 18639636-4 2008 ATP increases phosphorylation of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, at Ser31 with a potency similar to that for ERK1/2 phosphorylation, the kinase responsible for TH phosphorylation at this site. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 33-53 18639636-4 2008 ATP increases phosphorylation of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, at Ser31 with a potency similar to that for ERK1/2 phosphorylation, the kinase responsible for TH phosphorylation at this site. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 55-57 18486144-1 2008 Catechol O-methyltransferase (COMT) plays important roles in the metabolism of catecholamine neurotransmitters and catechol estrogens. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 30-34 18683481-1 2008 The synthetic vasopressin analogue, terlipressin, is being increasingly used to treat catecholamine-resistant hypotension in septic shock and other conditions. Catecholamines 86-99 arginine vasopressin Homo sapiens 14-25 18683484-1 2008 Vasopressin analogues are increasingly used for haemodynamic support of catecholamine-refractory, hyperdynamic septic shock. Catecholamines 72-85 arginine vasopressin Homo sapiens 0-11 18683484-2 2008 Arginine vasopressin (AVP) and terlipressin (TP) effectively increase mean arterial pressure and reduce catecholamine requirements in this condition. Catecholamines 104-117 arginine vasopressin Homo sapiens 9-20 18262211-4 2008 To data, a reduced hormone-sensitive lipase (HSL) expression is the best characterized defect contributing to this catecholamine resistance. Catecholamines 115-128 lipase, hormone sensitive Mus musculus 19-43 18248621-2 2008 Using amperometry to record quantal catecholamine release from chromaffin cells, we found that both broad spectrum PKC antagonists and rottlerin, a selective inhibitor of the novel isoforms PKC theta and PKC delta, decreased quantal size and the number of secretory events recorded per stimulus. Catecholamines 36-49 protein kinase C, theta Mus musculus 190-199 18349104-2 2008 One of these mechanisms is the up-regulation of tyrosine hydroxylase (TH), the enzyme that controls catecholamine biosynthesis. Catecholamines 100-113 tyrosine hydroxylase Mus musculus 48-68 18349104-2 2008 One of these mechanisms is the up-regulation of tyrosine hydroxylase (TH), the enzyme that controls catecholamine biosynthesis. Catecholamines 100-113 tyrosine hydroxylase Mus musculus 70-72 18501968-2 2008 These cardiostimulant beta-blockers, coined non-conventional partial agonists, antagonize the effects of catecholamines through a high-affinity site (beta(1H)AR), but cause cardiostimulation mainly through a low-affinity site (beta(1L)AR) of the myocardial beta(1)-adrenoceptor. Catecholamines 105-119 complement factor H Homo sapiens 150-157 18262211-4 2008 To data, a reduced hormone-sensitive lipase (HSL) expression is the best characterized defect contributing to this catecholamine resistance. Catecholamines 115-128 lipase, hormone sensitive Mus musculus 45-48 18395341-0 2008 Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells. Catecholamines 45-58 hypocretin neuropeptide precursor Rattus norvegicus 33-41 18375074-11 2008 In conclusion, intranasally administered OT leads to a marked increase in OT plasma levels together with increased secretion of catecholamines when subjects are engaged in sexual activity in a laboratory setting. Catecholamines 128-142 oxytocin/neurophysin I prepropeptide Homo sapiens 41-43 18495893-4 2008 Mice in which one allele of the CAPS-1 gene is deleted exhibit a deficit in catecholamine secretion from chromaffin cells. Catecholamines 76-89 Ca2+-dependent secretion activator Mus musculus 32-38 18495893-5 2008 We have examined catecholamine secretion from chromaffin cells in which both CAPS genes were deleted and show that the deletion of both CAPS isoforms causes a strong reduction in the pool of rapidly releasable chromaffin granules and of sustained release during ongoing stimulation. Catecholamines 17-30 Ca2+-dependent secretion activator Mus musculus 136-140 18395341-3 2008 In the present study, using the carbon-fiber amperometry, we investigated whether orexin A would stimulate catecholamine release from rat and mouse adrenal chromffin cells. Catecholamines 107-120 hypocretin neuropeptide precursor Rattus norvegicus 82-90 18395341-5 2008 Likewise, in the mouse adrenal medulla slices, orexin A also induced catecholamine release mainly through the activation of OX1R. Catecholamines 69-82 hypocretin Mus musculus 47-55 18395341-5 2008 Likewise, in the mouse adrenal medulla slices, orexin A also induced catecholamine release mainly through the activation of OX1R. Catecholamines 69-82 hypocretin (orexin) receptor 1 Mus musculus 124-128 18387083-16 2008 Our results suggest that CD1 mice are an ideal model system to study catecholamine-induced cardiac remodelling, as well as to screen candidate antifibrotic agents for future therapies. Catecholamines 69-82 CD1 antigen complex Mus musculus 25-28 18436820-11 2008 CONCLUSIONS: The authors provide evidence of an endogenous autocrine catecholamine signaling pathway dependent on an intact beta2-AR for the modulation of corneal epithelial wound repair. Catecholamines 69-82 adrenergic receptor, beta 2 Mus musculus 124-132 18473744-2 2008 SULT1A3 has catecholamines such as dopamine as substrates while SULT 1E1 sulfonates oestrogens. Catecholamines 12-26 sulfotransferase family 1A member 3 Homo sapiens 0-7 18202135-2 2008 Catecholamines directly stimulate GH, ACTH, and prolactin secretion from rat anterior pituitary through the beta(2)-adrenoceptor (AR). Catecholamines 0-14 adrenoceptor beta 2 Rattus norvegicus 108-128 18202135-2 2008 Catecholamines directly stimulate GH, ACTH, and prolactin secretion from rat anterior pituitary through the beta(2)-adrenoceptor (AR). Catecholamines 0-14 adrenoceptor beta 2 Rattus norvegicus 130-132 18346809-2 2008 The beta1 adrenergic receptor (BAR-1) is a major mediator of catecholamine-induced lipolysis and thermogenesis. Catecholamines 61-74 adrenoceptor beta 1 Homo sapiens 4-29 18304530-1 2008 Using urethane-anesthetized rats, we examined whether an activation of nuclear factor kappa B is involved in the corticotropin-releasing factor-induced increase in plasma levels of catecholamines. Catecholamines 181-195 corticotropin releasing hormone Rattus norvegicus 113-143 18442637-1 2008 Catechol O-methyltransferase (COMT) degrades catecholamines and estrogens, both of which are of known importance for cardiovascular risk factors such as obesity and hypertension. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 0-28 18442637-1 2008 Catechol O-methyltransferase (COMT) degrades catecholamines and estrogens, both of which are of known importance for cardiovascular risk factors such as obesity and hypertension. Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 30-34 18425130-4 2008 GRK5-Leu41 uncoupled isoproterenol-stimulated responses more effectively than did GRK5-Gln41 in transfected cells and transgenic mice, and, like pharmacological betaAR blockade, GRK5-Leu41 protected against experimental catecholamine-induced cardiomyopathy. Catecholamines 220-233 G protein-coupled receptor kinase 5 Mus musculus 0-4 18425130-7 2008 Enhanced betaAR desensitization of excessive catecholamine signaling by GRK5-Leu41 provides a "genetic beta-blockade" that improves survival in African Americans with heart failure, suggesting a reason for conflicting results of beta-blocker clinical trials in this population. Catecholamines 45-58 G protein-coupled receptor kinase 5 Homo sapiens 72-76 18844111-0 2008 [Correlation of tip perfusion index with hemodynamics and catecholamines in patients undergoing general anesthesia]. Catecholamines 58-72 TOR signaling pathway regulator Homo sapiens 16-19 18844111-1 2008 OBJECTIVE: To explore the correlation of tip perfusion index (TPI) with the hemodynamics and catecholamines and to assess the value and meaning of TPI for monitoring stress responses in general anesthesia. Catecholamines 93-107 TOR signaling pathway regulator Homo sapiens 41-44 18385323-5 2008 Rat cells transduced with Ngn2 exited the cell cycle and expressed the neuronal marker microtubule-associated protein 2 and catecholamine-neuron protein vesicular monoamine transporter 2. Catecholamines 124-137 neurogenin 2 Rattus norvegicus 26-30 18385326-4 2008 Adeno-associated viral delivery of a cleavage-resistant S25 gene (S25-R198T) to chromaffin cells in vitro yielded exocytotically active S25-R198T that diminished subsequent blockade by BoNT/A of evoked catecholamine release. Catecholamines 202-215 synaptosome associated protein 25 Homo sapiens 56-59 18385326-4 2008 Adeno-associated viral delivery of a cleavage-resistant S25 gene (S25-R198T) to chromaffin cells in vitro yielded exocytotically active S25-R198T that diminished subsequent blockade by BoNT/A of evoked catecholamine release. Catecholamines 202-215 synaptosome associated protein 25 Homo sapiens 66-69 18385326-4 2008 Adeno-associated viral delivery of a cleavage-resistant S25 gene (S25-R198T) to chromaffin cells in vitro yielded exocytotically active S25-R198T that diminished subsequent blockade by BoNT/A of evoked catecholamine release. Catecholamines 202-215 synaptosome associated protein 25 Homo sapiens 66-69 18180251-6 2008 Changes in single-vesicle fusion kinetics are also evident resulting in the less catecholamine released per vesicle with increasing Rcan1 expression. Catecholamines 81-94 regulator of calcineurin 1 Mus musculus 132-137 18079203-6 2008 Pharmacological inhibition (predominantly through beta-adrenergic receptor) of the stress-released catecholamines in the central nervous system regulates 15d-PGJ(2) and PGE(2) synthesis, by reducing COX-2 overexpression, and reduces PPARgamma activation. Catecholamines 99-113 cytochrome c oxidase II, mitochondrial Rattus norvegicus 199-204 18079203-6 2008 Pharmacological inhibition (predominantly through beta-adrenergic receptor) of the stress-released catecholamines in the central nervous system regulates 15d-PGJ(2) and PGE(2) synthesis, by reducing COX-2 overexpression, and reduces PPARgamma activation. Catecholamines 99-113 peroxisome proliferator-activated receptor gamma Rattus norvegicus 233-242 18036192-8 2008 Thus, LPA-LPA(1) receptor-Rho/Rho kinase pathway up-regulated cell surface Nav1.7 and Nav1.7 mRNA levels, enhancing veratridine-induced Ca2+ influx and catecholamine secretion. Catecholamines 152-165 lysophosphatidic acid receptor 1 Bos taurus 10-16 18349695-3 2008 PACAP is a neuropeptide involved in neurotransmission in both the peripheral nervous system and central nervous system and is required for catecholamine secretion. Catecholamines 139-152 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 18299506-0 2008 Catecholamines regulate the activity, secretion, and synthesis of renalase. Catecholamines 0-14 renalase, FAD-dependent amine oxidase Rattus norvegicus 66-74 18447638-5 2008 Furthermore, we showed enrichment of USSCs expressing tyrosine hydroxylase (TH), an enzyme specific for dopaminergic neurons and other catecholamine-producing neurons, accompanied by induction of Nurr1, a factor regulating dopaminergic neurogenesis. Catecholamines 135-148 tyrosine hydroxylase Homo sapiens 54-74 18447638-5 2008 Furthermore, we showed enrichment of USSCs expressing tyrosine hydroxylase (TH), an enzyme specific for dopaminergic neurons and other catecholamine-producing neurons, accompanied by induction of Nurr1, a factor regulating dopaminergic neurogenesis. Catecholamines 135-148 tyrosine hydroxylase Homo sapiens 76-78 18447638-5 2008 Furthermore, we showed enrichment of USSCs expressing tyrosine hydroxylase (TH), an enzyme specific for dopaminergic neurons and other catecholamine-producing neurons, accompanied by induction of Nurr1, a factor regulating dopaminergic neurogenesis. Catecholamines 135-148 nuclear receptor subfamily 4 group A member 2 Homo sapiens 196-201 18222006-1 2008 Pre-synaptic dopamine, norepinephrine and serotonin transporters (DAT, NET and SERT) terminate synaptic catecholamine transmission through reuptake of released neurotransmitter. Catecholamines 104-117 solute carrier family 6 member 3 Homo sapiens 66-69 18222006-1 2008 Pre-synaptic dopamine, norepinephrine and serotonin transporters (DAT, NET and SERT) terminate synaptic catecholamine transmission through reuptake of released neurotransmitter. Catecholamines 104-117 solute carrier family 6 member 2 Homo sapiens 71-74 18222006-1 2008 Pre-synaptic dopamine, norepinephrine and serotonin transporters (DAT, NET and SERT) terminate synaptic catecholamine transmission through reuptake of released neurotransmitter. Catecholamines 104-117 solute carrier family 6 member 4 Homo sapiens 79-83 18367602-2 2008 Chromaffin cells from Chga null mice [chromogranin A knock-out (CgA-KO)] exhibited approximately 30% reduction in the content and in the release of catecholamines compared with wild type. Catecholamines 148-162 chromogranin A Mus musculus 38-52 18191965-4 2008 Here, we examine whether catecholamine-containing neurons in these regions exhibit the immediate early gene, ZENK, during spontaneous, undirected song production in male zebra finches (Taeniopygia guttata). Catecholamines 25-38 early growth response protein 1 Taeniopygia guttata 109-113 18335062-1 2008 BACKGROUND: Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored tri- and diglycerides, thus mobilizing fatty acids. Catecholamines 125-138 lipase, hormone sensitive Mus musculus 12-36 18335062-1 2008 BACKGROUND: Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored tri- and diglycerides, thus mobilizing fatty acids. Catecholamines 125-138 lipase, hormone sensitive Mus musculus 38-41 18299506-1 2008 BACKGROUND: We previously identified renalase, a secreted novel amine oxidase that specifically degrades circulating catecholamines. Catecholamines 117-131 renalase, FAD-dependent amine oxidase Rattus norvegicus 37-45 18299506-2 2008 Parenteral administration of either native or recombinant renalase lowers blood pressure, heart rate, and cardiac contractility by metabolizing circulating catecholamines. Catecholamines 156-170 renalase, FAD-dependent amine oxidase Rattus norvegicus 58-66 18299506-8 2008 The catecholamine surge also leads to a 2.8-fold increase in plasma renalase concentration. Catecholamines 4-17 renalase, FAD-dependent amine oxidase Rattus norvegicus 68-76 18299506-12 2008 In the renalase pathway, excess catecholamine facilitates the conversion of prorenalase, an inactive plasma amine oxidase, to renalase, which can degrade catecholamines. Catecholamines 32-45 renalase, FAD-dependent amine oxidase Rattus norvegicus 7-15 18299506-12 2008 In the renalase pathway, excess catecholamine facilitates the conversion of prorenalase, an inactive plasma amine oxidase, to renalase, which can degrade catecholamines. Catecholamines 32-45 renalase, FAD-dependent amine oxidase Rattus norvegicus 79-87 18299506-12 2008 In the renalase pathway, excess catecholamine facilitates the conversion of prorenalase, an inactive plasma amine oxidase, to renalase, which can degrade catecholamines. Catecholamines 154-168 renalase, FAD-dependent amine oxidase Rattus norvegicus 7-15 18299506-12 2008 In the renalase pathway, excess catecholamine facilitates the conversion of prorenalase, an inactive plasma amine oxidase, to renalase, which can degrade catecholamines. Catecholamines 154-168 renalase, FAD-dependent amine oxidase Rattus norvegicus 79-87 18299506-14 2008 Because chronic kidney disease is associated with a number of systemic abnormalities, including activation of the sympathetic nervous system, increased catecholamines levels, cardiac hypertrophy, and hypertension, renalase replacement is an attractive therapeutic modality owing to its role in catecholamine metabolism. Catecholamines 152-166 renalase, FAD-dependent amine oxidase Rattus norvegicus 214-222 18299506-14 2008 Because chronic kidney disease is associated with a number of systemic abnormalities, including activation of the sympathetic nervous system, increased catecholamines levels, cardiac hypertrophy, and hypertension, renalase replacement is an attractive therapeutic modality owing to its role in catecholamine metabolism. Catecholamines 152-165 renalase, FAD-dependent amine oxidase Rattus norvegicus 214-222 18277152-4 2008 Catecholamine administration promotes the secretion of preformed renalase within 5 min. Catecholamines 0-13 renalase, FAD dependent amine oxidase Homo sapiens 65-73 18081903-0 2008 Vasopressin in catecholamine-refractory shock in children. Catecholamines 15-28 arginine vasopressin Homo sapiens 0-11 18431272-13 2008 CONCLUSIONS: Some catecholamines can induce an inflammatory response and exacerbate the hepatic dysfunction observed during sepsis, favoring the idea that catecholamines could alter the biotransformation of drugs metabolized by CYP3A4 and that alternative vasoactive agents, such as vasopressin, merit further investigation in septic shock patients. Catecholamines 18-32 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 228-234 18431272-13 2008 CONCLUSIONS: Some catecholamines can induce an inflammatory response and exacerbate the hepatic dysfunction observed during sepsis, favoring the idea that catecholamines could alter the biotransformation of drugs metabolized by CYP3A4 and that alternative vasoactive agents, such as vasopressin, merit further investigation in septic shock patients. Catecholamines 18-32 arginine vasopressin Homo sapiens 283-294 18431272-13 2008 CONCLUSIONS: Some catecholamines can induce an inflammatory response and exacerbate the hepatic dysfunction observed during sepsis, favoring the idea that catecholamines could alter the biotransformation of drugs metabolized by CYP3A4 and that alternative vasoactive agents, such as vasopressin, merit further investigation in septic shock patients. Catecholamines 155-169 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 228-234 18431272-13 2008 CONCLUSIONS: Some catecholamines can induce an inflammatory response and exacerbate the hepatic dysfunction observed during sepsis, favoring the idea that catecholamines could alter the biotransformation of drugs metabolized by CYP3A4 and that alternative vasoactive agents, such as vasopressin, merit further investigation in septic shock patients. Catecholamines 155-169 arginine vasopressin Homo sapiens 283-294 18277152-8 2008 In this pathway, prorenalase is rapidly activated by increased catecholamines and converted to renalase, which in turn degrades catecholamines. Catecholamines 63-77 renalase, FAD dependent amine oxidase Homo sapiens 20-28 18277152-8 2008 In this pathway, prorenalase is rapidly activated by increased catecholamines and converted to renalase, which in turn degrades catecholamines. Catecholamines 128-142 renalase, FAD dependent amine oxidase Homo sapiens 20-28 18277152-7 2008 SUMMARY: The renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, cardiac function and blood pressure. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 13-21 18235090-2 2008 Specific endopeptidases cleave chromogranin A into biologically active peptide fragments, including catestatin, which inhibits catecholamine release. Catecholamines 127-140 chromogranin A Homo sapiens 31-45 17431678-0 2008 Arginine-vasopressin as a rescue therapy in children and neonates for catecholamine-resistant shock. Catecholamines 70-83 arginine vasopressin Homo sapiens 9-20 18235090-2 2008 Specific endopeptidases cleave chromogranin A into biologically active peptide fragments, including catestatin, which inhibits catecholamine release. Catecholamines 127-140 chromogranin A Homo sapiens 100-110 17896792-2 2008 We previously reported that phosphorylation of ATF-2 increased the expression of tyrosine hydroxylase (TH), which is the rate-limiting enzyme for catecholamine biosynthesis, directly acting on the CRE in the promoter region of the TH gene in PC12D cells (Suzuki et al. Catecholamines 146-159 activating transcription factor 2 Rattus norvegicus 47-52 18189154-9 2008 Our data demonstrate that ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue. Catecholamines 89-102 patatin like phospholipase domain containing 2 Sus scrofa 26-30 18771016-1 2008 N-methylpropargylamine-1-aminoindane (J-508), a strong releaser of catecholamines was described 30 years ago as a more potent selective inhibitor of MAO-B than (-)-deprenyl (Knoll 1978). Catecholamines 67-81 monoamine oxidase B Rattus norvegicus 149-154 18040081-3 2008 We focused on NTS catecholamine neurons because these cells have been implicated in the feeding response to CCK. Catecholamines 18-31 cholecystokinin Rattus norvegicus 108-111 18040081-8 2008 These histochemical findings identify hindbrain catecholamine cells as potential mediators of the interaction between leptin and CCK. Catecholamines 48-61 leptin Rattus norvegicus 118-124 18040081-8 2008 These histochemical findings identify hindbrain catecholamine cells as potential mediators of the interaction between leptin and CCK. Catecholamines 48-61 cholecystokinin Rattus norvegicus 129-132 18201726-1 2008 We investigated the role played by catecholamine-dependent pathways in modulating the ability of centrally administered corticotropin releasing factor (CRF) to activate sympatho-adrenomedullay outflow, using urethane-anesthetized rats. Catecholamines 35-48 corticotropin releasing hormone Rattus norvegicus 120-150 17896792-2 2008 We previously reported that phosphorylation of ATF-2 increased the expression of tyrosine hydroxylase (TH), which is the rate-limiting enzyme for catecholamine biosynthesis, directly acting on the CRE in the promoter region of the TH gene in PC12D cells (Suzuki et al. Catecholamines 146-159 tyrosine hydroxylase Rattus norvegicus 81-101 17896792-2 2008 We previously reported that phosphorylation of ATF-2 increased the expression of tyrosine hydroxylase (TH), which is the rate-limiting enzyme for catecholamine biosynthesis, directly acting on the CRE in the promoter region of the TH gene in PC12D cells (Suzuki et al. Catecholamines 146-159 tyrosine hydroxylase Rattus norvegicus 103-105 17896792-2 2008 We previously reported that phosphorylation of ATF-2 increased the expression of tyrosine hydroxylase (TH), which is the rate-limiting enzyme for catecholamine biosynthesis, directly acting on the CRE in the promoter region of the TH gene in PC12D cells (Suzuki et al. Catecholamines 146-159 tyrosine hydroxylase Rattus norvegicus 231-233 18181650-1 2008 Tyrosine hydroxylase (TH) catalyzes the first step in the biosynthesis of catecholamines. Catecholamines 74-88 tyrosine hydroxylase Homo sapiens 0-20 18181650-1 2008 Tyrosine hydroxylase (TH) catalyzes the first step in the biosynthesis of catecholamines. Catecholamines 74-88 tyrosine hydroxylase Homo sapiens 22-24 18094025-9 2008 We demonstrate that the fetal lethality of Insm1 mutant mice is caused by catecholamine deficiency, which highlights the importance of Insm1 in the development of the sympatho-adrenal lineage. Catecholamines 74-87 insulinoma-associated 1 Mus musculus 43-48 18190898-1 2008 Egr1, a transcription factor rapidly induced by various stimuli including stress, can elevate transcription of genes for the catecholamine biosynthetic enzymes TH and PNMT. Catecholamines 125-138 early growth response 1 Rattus norvegicus 0-4 18190898-1 2008 Egr1, a transcription factor rapidly induced by various stimuli including stress, can elevate transcription of genes for the catecholamine biosynthetic enzymes TH and PNMT. Catecholamines 125-138 phenylethanolamine-N-methyltransferase Rattus norvegicus 167-171 18094025-9 2008 We demonstrate that the fetal lethality of Insm1 mutant mice is caused by catecholamine deficiency, which highlights the importance of Insm1 in the development of the sympatho-adrenal lineage. Catecholamines 74-87 insulinoma-associated 1 Mus musculus 135-140 18180394-9 2008 Two genetic loci significantly predicted vascular response: chromogranin B, which encodes a protein that catalyzes catecholamine vesicle formation (CHGB, exon 4, Glu348Glu; P=0.002), and cytochrome b-561 (CYB561, intron 1, C719G; P<0.001), an electron shuttle for catecholamine synthesis. Catecholamines 115-128 chromogranin B Homo sapiens 60-74 17991725-3 2008 Resequencing of the human CHGA gene identified three naturally occurring variants of catestatin (Gly364Ser, Pro370Leu, and Arg374Gln) that exhibit different potencies in inhibiting catecholamine secretion. Catecholamines 181-194 chromogranin A Homo sapiens 26-30 17991725-3 2008 Resequencing of the human CHGA gene identified three naturally occurring variants of catestatin (Gly364Ser, Pro370Leu, and Arg374Gln) that exhibit different potencies in inhibiting catecholamine secretion. Catecholamines 181-194 chromogranin A Homo sapiens 85-95 18223549-0 2008 Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity. Catecholamines 22-35 G protein-coupled receptor kinase 2 Rattus norvegicus 91-126 18223549-1 2008 We recently reported that the upregulation of adrenal G protein-coupled receptor kinase-2 (GRK2) causes enhanced catecholamine (CA) secretion by desensitizing sympatho-inhibitory alpha (2)-adrenergic receptors (alpha (2)ARs) of chromaffin cells, and thereby aggravating heart failure (HF). Catecholamines 113-126 G protein-coupled receptor kinase 2 Rattus norvegicus 54-89 18223549-1 2008 We recently reported that the upregulation of adrenal G protein-coupled receptor kinase-2 (GRK2) causes enhanced catecholamine (CA) secretion by desensitizing sympatho-inhibitory alpha (2)-adrenergic receptors (alpha (2)ARs) of chromaffin cells, and thereby aggravating heart failure (HF). Catecholamines 113-126 G protein-coupled receptor kinase 2 Rattus norvegicus 91-95 18096443-1 2008 The human zinc finger protein 191 (ZNF191) is a Kruppel-like protein and can specifically interact with the widespread TCAT motif which constitutes the HUMTH01 microsatellite in the tyrosine hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines). Catecholamines 268-282 zinc finger protein 24 Homo sapiens 10-33 18096443-1 2008 The human zinc finger protein 191 (ZNF191) is a Kruppel-like protein and can specifically interact with the widespread TCAT motif which constitutes the HUMTH01 microsatellite in the tyrosine hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines). Catecholamines 268-282 zinc finger protein 24 Homo sapiens 35-41 18096443-1 2008 The human zinc finger protein 191 (ZNF191) is a Kruppel-like protein and can specifically interact with the widespread TCAT motif which constitutes the HUMTH01 microsatellite in the tyrosine hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines). Catecholamines 268-282 tyrosine hydroxylase Homo sapiens 182-202 18096443-1 2008 The human zinc finger protein 191 (ZNF191) is a Kruppel-like protein and can specifically interact with the widespread TCAT motif which constitutes the HUMTH01 microsatellite in the tyrosine hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines). Catecholamines 268-282 tyrosine hydroxylase Homo sapiens 155-157 18234565-2 2008 The aim of this study was to determine the effect of exogenous catecholamines on tumor necrosis factor alpha (TNFa), interleukin-6 (IL-6), interleukin-10 (IL-10) and beta(beta)-endorphin levels in patients with severe trauma, during the first 24 h after injury. Catecholamines 63-77 tumor necrosis factor Homo sapiens 81-108 18234565-6 2008 Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and beta-endorphin levels in patients treated with catecholamines. Catecholamines 175-189 tumor necrosis factor Homo sapiens 106-110 18234565-6 2008 Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and beta-endorphin levels in patients treated with catecholamines. Catecholamines 175-189 interleukin 6 Homo sapiens 112-116 18234565-6 2008 Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and beta-endorphin levels in patients treated with catecholamines. Catecholamines 175-189 interleukin 10 Homo sapiens 118-123 18234565-6 2008 Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and beta-endorphin levels in patients treated with catecholamines. Catecholamines 175-189 proopiomelanocortin Homo sapiens 128-142 18180394-9 2008 Two genetic loci significantly predicted vascular response: chromogranin B, which encodes a protein that catalyzes catecholamine vesicle formation (CHGB, exon 4, Glu348Glu; P=0.002), and cytochrome b-561 (CYB561, intron 1, C719G; P<0.001), an electron shuttle for catecholamine synthesis. Catecholamines 115-128 chromogranin B Homo sapiens 148-152 17973897-11 2008 Although the mechanism underlying the stress effect on CYP1A2 induction has not been clearly elucidated, it appears that peripheral catecholamines hold a predominant role, while central catecholamines and in particular, central noradrenergic pathways hold a minor role. Catecholamines 132-146 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 55-61 18183302-7 2008 This region contains several genes which have previously been associated with the function of dopaminergic neurons, including the gene for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, IGF2, and CDKN1C, which cooperates with Nurr1 in directing the differentiation of dopaminergic neurons. Catecholamines 194-207 tyrosine hydroxylase Homo sapiens 139-159 17988693-1 2008 This study investigated the role of catecholamine-related signaling pathways in the regulation of hepatic cytochrome P450 (CYP2E1). Catecholamines 36-49 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 123-129 17988693-2 2008 Central and peripheral catecholamine depletion with reserpine down-regulated CYP2E1. Catecholamines 23-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 77-83 17988693-3 2008 On the other hand, selective peripheral catecholamine depletion with guanethidine increased CYP2E1 apoprotein levels. Catecholamines 40-53 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 92-98 17988693-7 2008 These findings indicate that central and peripheral catecholamines have different effects on CYP2E1. Catecholamines 52-66 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 93-99 18591481-4 2008 In line with catecholamine models of sustained attention, associations have been reported between sustained attention and allelic variation in the dopamine beta hydroxylase gene (DBH), the dopamine D2 and D4 receptor genes (DRD2; DRD4) and the dopamine transporter gene (DAT1). Catecholamines 13-26 dopamine beta-hydroxylase Homo sapiens 147-172 18591481-4 2008 In line with catecholamine models of sustained attention, associations have been reported between sustained attention and allelic variation in the dopamine beta hydroxylase gene (DBH), the dopamine D2 and D4 receptor genes (DRD2; DRD4) and the dopamine transporter gene (DAT1). Catecholamines 13-26 dopamine beta-hydroxylase Homo sapiens 179-182 18591481-4 2008 In line with catecholamine models of sustained attention, associations have been reported between sustained attention and allelic variation in the dopamine beta hydroxylase gene (DBH), the dopamine D2 and D4 receptor genes (DRD2; DRD4) and the dopamine transporter gene (DAT1). Catecholamines 13-26 dopamine receptor D2 Homo sapiens 224-228 17973897-0 2008 Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Catecholamines 31-45 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 82-88 17973897-3 2008 The data show that stress is a significant factor in the regulation of CYP1A2 induction and that catecholamines play a central role in the stress-mediated modulation of hepatic CYP1A2 inducibility by benzo(alpha)pyrene. Catecholamines 97-111 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 177-183 19040557-1 2008 Aromatic L-amino acid decarboxylase (AAAD) is an essential enzyme for the formation of catecholamines, indolamines, and trace amines. Catecholamines 87-101 dopa decarboxylase Homo sapiens 0-35 17973897-4 2008 The up-regulating effect of stress on benzo(alpha)pyrene-induced CYP1A2 gene expression was eliminated after a generalized catecholamine depletion with reserpine. Catecholamines 123-136 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 65-71 17973897-6 2008 It is apparent that stress up-regulates the induction of CYP1A2 by benzo(alpha)pyrene mainly via peripheral catecholamines, while central catecholamines hold a minor role in the regulation. Catecholamines 108-122 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 57-63 17973897-6 2008 It is apparent that stress up-regulates the induction of CYP1A2 by benzo(alpha)pyrene mainly via peripheral catecholamines, while central catecholamines hold a minor role in the regulation. Catecholamines 138-152 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 57-63 18194084-7 2008 In vitro incubation of the modulated AChE and Na+, K+-ATPase with L-C (25 microM) from group B and group D resulted in a non-significant reduction of the enzymes in group B and complete restoration of their activities in group D. CONCLUSIONS: The increase of AChE and Na+, K+-ATPase activities may be due to the elevation of catecholamines in group B. Catecholamines 325-339 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 19040557-1 2008 Aromatic L-amino acid decarboxylase (AAAD) is an essential enzyme for the formation of catecholamines, indolamines, and trace amines. Catecholamines 87-101 dopa decarboxylase Homo sapiens 37-41 18048093-4 2008 PACAP also acts as a neurotransmitter to stimulate catecholamine and neuropeptide biosynthesis and release from sympathetic neurons and chromaffin cells, during development and in adulthood. Catecholamines 51-64 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 18537611-2 2008 Its function is primarily controlled by the anabolic hormone insulin and its counterparts glucagon, catecholamines and glucocorticoids. Catecholamines 100-114 insulin Homo sapiens 61-68 18032795-8 2008 Instead, urinary catecholamine levels in 11betaHSD2(-/-) mice were double those in wild-type mice, and alpha1-adrenergic receptor blockade rescued the hypertensive phenotype, suggesting that vasoconstriction contributes to the sustained hypertension in this model. Catecholamines 17-30 hydroxysteroid 11-beta dehydrogenase 2 Mus musculus 41-51 18090541-2 2008 In the present study, we tested the hypothesis that the beta fragment of human coagulation factor XIIa (beta-FXIIa) induces adrenal catecholamine-mediated pressor and chronotropic responses via bradykinin generated from the plasma kallikrein-kinin system. Catecholamines 132-145 kininogen 1 Homo sapiens 194-204 18090541-6 2008 Exogenous bradykinin dose-dependently reproduced these catecholamine and haemodynamic responses in Brown Norway and BNK rats, but not in Brown Norway adrenal medullectomized rats. Catecholamines 55-68 kininogen 1 Homo sapiens 10-20 19020660-3 2008 METHODS AND FINDINGS: We investigated the effects of apoB-containing lipoproteins on catecholamine-induced lipolysis in adipocytes from subcutaneous fat cells of obese but otherwise healthy men, fat pads from mice with plasma lipoproteins containing high or intermediate levels of apoB100 or no apoB100, primary cultured adipocytes, and 3T3-L1 cells. Catecholamines 85-98 apolipoprotein B Mus musculus 53-57 19091080-2 2008 In septic shock, endogenous catecholamines induce beta2-AR downregulation, leading to an increased TNF-alpha release. Catecholamines 28-42 adrenoceptor beta 2 Homo sapiens 50-58 19091080-2 2008 In septic shock, endogenous catecholamines induce beta2-AR downregulation, leading to an increased TNF-alpha release. Catecholamines 28-42 tumor necrosis factor Homo sapiens 99-108 19091080-12 2008 CONCLUSIONS: In septic shock, the anti-inflammatory effects of catecholamines are blunted by downregulation of beta2-ARs and upregulation of the inhibitory G protein in CD14+ monocytes. Catecholamines 63-77 CD14 molecule Homo sapiens 169-173 19704445-2 2008 Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription. Catecholamines 88-102 monoamine oxidase A Mus musculus 27-46 19704445-2 2008 Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription. Catecholamines 88-102 monoamine oxidase A Mus musculus 48-52 19704445-2 2008 Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription. Catecholamines 88-102 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 307-312 19704445-2 2008 Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription. Catecholamines 88-102 neuronal PAS domain protein 2 Mus musculus 313-318 19704445-2 2008 Now, we have reported that monoamine oxidase A (MAOA), a mitochondrial enzyme degrading catecholamines including dopamine, is regulated by components of the circadian clock.4 Interestingly, this regulation is variable depending on cell type, indicating the presence of cell type specific factors modulating BMAL1/NPAS2 or BMAL1/CLOCK dependent transcription. Catecholamines 88-102 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 322-327 17962330-4 2007 However, recently it has become apparent that AMPK in mammals is also regulated by humoral substances, e.g. catecholamines. Catecholamines 108-122 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 46-50 18679017-8 2008 AT2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. Catecholamines 136-149 angiotensin II receptor, type 2 Rattus norvegicus 0-3 18679017-8 2008 AT2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. Catecholamines 136-149 FOS like 2, AP-1 transcription factor subunit Rattus norvegicus 44-49 17884041-8 2007 Cardiovascular responses to CDP-choline, phosphocholine and choline, but not cytidine monophosphate or cytidine, were associated with elevated plasma catecholamines concentrations. Catecholamines 150-164 cut-like homeobox 1 Rattus norvegicus 28-31 17510945-3 2007 A functional polymorphism on the human catechol-O-methyltransferase (COMT) gene, which codes for the catecholamines inactivating enzyme COMT, has been shown to influence aggressive and anger-related traits in various clinical populations. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 39-67 17510945-3 2007 A functional polymorphism on the human catechol-O-methyltransferase (COMT) gene, which codes for the catecholamines inactivating enzyme COMT, has been shown to influence aggressive and anger-related traits in various clinical populations. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 69-73 17510945-3 2007 A functional polymorphism on the human catechol-O-methyltransferase (COMT) gene, which codes for the catecholamines inactivating enzyme COMT, has been shown to influence aggressive and anger-related traits in various clinical populations. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 136-140 17525973-2 2007 Two genes that have been highlighted in the literature as being involved are HTR1B, which codes for the serotonin 1B receptor, and COMT, which is related to the inactivation of catecholamines. Catecholamines 177-191 5-hydroxytryptamine receptor 1B Homo sapiens 77-82 17525973-2 2007 Two genes that have been highlighted in the literature as being involved are HTR1B, which codes for the serotonin 1B receptor, and COMT, which is related to the inactivation of catecholamines. Catecholamines 177-191 catechol-O-methyltransferase Homo sapiens 131-135 18053221-17 2007 The inverse correlation between ESR1 mRNA levels and lipolytic responsiveness to adrenoceptor agonists implies that low adipose tissue ESR1 levels attenuate catecholamine resistance in sc fat cells of obese women hereby contributing to loss of sc and gain of visceral fat. Catecholamines 157-170 estrogen receptor 1 Homo sapiens 135-139 18064318-2 2007 Catechol-O-methyltransferase (COMT) is involved in the S-adenosylmethionine-dependent methylation of catecholamines and catecholestrogens and in this way contributes to homocysteine synthesis. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 0-28 17982355-9 2007 This information is relayed to the forebrain via projections containing catecholamines and neuropeptide-Y, where they activate corticotropin-releasing hormone neurons. Catecholamines 72-86 corticotropin releasing hormone Homo sapiens 127-158 17999941-9 2007 Activation of the beta3-AR pathway by catecholamines may contribute to the myocardial dysfunction in sepsis. Catecholamines 38-52 adrenergic receptor, beta 3 Mus musculus 18-26 17982691-5 2007 Given the striking similarities between the enzymatic steps in the morphine biosynthetic pathway and those driving the evolutionary adaptation of catecholamine chemical species to accommodate an expansion of interactive but distinct signaling systems, we surmise that the evolutionary emergence of catecholamine systems required conservation and selective "retrofit" of specific enzyme activities, i.e. catechol O-methyl transferase and phenylethanol-amine N-methyl transferase, drawn from cellular morphine expression. Catecholamines 298-311 catechol-O-methyltransferase Homo sapiens 403-432 17982691-5 2007 Given the striking similarities between the enzymatic steps in the morphine biosynthetic pathway and those driving the evolutionary adaptation of catecholamine chemical species to accommodate an expansion of interactive but distinct signaling systems, we surmise that the evolutionary emergence of catecholamine systems required conservation and selective "retrofit" of specific enzyme activities, i.e. catechol O-methyl transferase and phenylethanol-amine N-methyl transferase, drawn from cellular morphine expression. Catecholamines 298-311 phenylethanolamine N-methyltransferase Homo sapiens 437-477 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 49-76 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 78-82 18052900-5 2007 Three higher-quality studies of catecholamines (noradrenaline, adrenaline, dopamine and vasopressin) have been completed, the results of which will provide some evidence of efficacy of catecholamines on mortality and resolution of shock. Catecholamines 185-199 arginine vasopressin Homo sapiens 88-99 17926059-10 2007 The aim of this study was to observe the changes in expression of IL-1RI and tyrosine hydroxylase (TH), a rate-limiting enzyme for catecholamine synthesis, in the glomus cells of the rat carotid body following intraperitoneal injection of IL-1beta. Catecholamines 131-144 tyrosine hydroxylase Rattus norvegicus 77-97 17926059-10 2007 The aim of this study was to observe the changes in expression of IL-1RI and tyrosine hydroxylase (TH), a rate-limiting enzyme for catecholamine synthesis, in the glomus cells of the rat carotid body following intraperitoneal injection of IL-1beta. Catecholamines 131-144 tyrosine hydroxylase Rattus norvegicus 99-101 17851041-3 2007 PLP is a metabolically-active form of vitamin B(6) and thus, is required as a co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Catecholamines 184-197 pyridoxal phosphatase Homo sapiens 0-3 18064318-2 2007 Catechol-O-methyltransferase (COMT) is involved in the S-adenosylmethionine-dependent methylation of catecholamines and catecholestrogens and in this way contributes to homocysteine synthesis. Catecholamines 101-115 catechol-O-methyltransferase Homo sapiens 30-34 17900529-1 2007 Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis, and its N-terminus plays a critical role in the intracellular stability of the enzyme. Catecholamines 52-65 tyrosine hydroxylase Homo sapiens 0-20 17962519-3 2007 Analysis of adrenergic receptor ligand-binding mutants within the context of the reported high-resolution structure of beta2AR-T4L provides insights into inverse-agonist binding and the structural changes required to accommodate catecholamine agonists. Catecholamines 229-242 adrenoceptor beta 2 Homo sapiens 119-126 17959316-9 2007 The present data indicate that the cerebellum does represent a target of methamphetamine, which produces specific and fine alterations of the catecholamine system involving synthesis, amount, and compartmentalization of TH as well as increased noradrenaline levels. Catecholamines 142-155 tyrosine hydroxylase Homo sapiens 220-222 17895242-2 2007 The present study showed that leptin, a centrally acting hormone secreted by adipocytes, rescued dopaminergic neurons, reversed behavioral asymmetry, and restored striatal catecholamine levels in the unilateral 6-hydroxydopamine (6-OHDA) mouse model of dopaminergic cell death. Catecholamines 172-185 leptin Mus musculus 30-36 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 89-103 catechol-O-methyltransferase Rattus norvegicus 14-42 17850222-1 2007 OBJECTIVE: To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking. Catecholamines 158-171 catechol-O-methyltransferase Homo sapiens 69-97 17850222-1 2007 OBJECTIVE: To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking. Catecholamines 158-171 catechol-O-methyltransferase Homo sapiens 99-103 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 89-103 catechol-O-methyltransferase Rattus norvegicus 44-48 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 105-108 catechol-O-methyltransferase Rattus norvegicus 14-42 17978496-1 2007 Metabolism by catechol-O-methyltransferase (COMT) is one of the inactivation pathways of catecholamines (CAs), which are important hormones in regulating blood pressure both in central and in peripheral sympathetic nerve endings. Catecholamines 105-108 catechol-O-methyltransferase Rattus norvegicus 44-48 17893275-0 2007 Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress. Catecholamines 142-155 thymoma viral proto-oncogene 1 Mus musculus 118-121 18210787-3 2007 We could measure biopterin and the GCH activity, since we had worked on catecholamine- and biopterin-synthesizing enzymes for many years. Catecholamines 72-85 GTP cyclohydrolase 1 Homo sapiens 35-38 17974982-6 2007 Catecholamine-mediated STAT3 activation was not inhibited by pretreatment with an anti-interleukin 6 (IL-6) antibody or with small interfering RNA (siRNA)-mediated decrease in IL-6 or gp130. Catecholamines 0-13 signal transducer and activator of transcription 3 Mus musculus 23-28 17702852-7 2007 In summary, infusion of IGF-I in late gestation resulted in a marked hypertrophy of the steroidogenic and adrenaline-containing cells of the fetal adrenal in the absence of changes in the mRNA levels of adrenal steroidogenic or catecholamine-synthetic enzymes or in fetal plasma cortisol concentrations. Catecholamines 228-241 insulin-like growth factor I Ovis aries 24-29 17868303-0 2007 Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells. Catecholamines 45-58 neuropeptide Y Mus musculus 86-89 17868303-2 2007 NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. Catecholamines 15-28 neuropeptide Y Mus musculus 0-3 17868303-2 2007 NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. Catecholamines 15-28 neuropeptide Y Mus musculus 45-48 17868303-3 2007 The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release from mouse chromaffin cells. Catecholamines 139-152 neuropeptide Y Mus musculus 84-87 17868303-6 2007 Moreover, catecholamine release stimulated by NPY or by the nitric oxide donor (NOC-18) was inhibited by mitogen-activated protein kinase (MAPK) and protein kinase C inhibitors. Catecholamines 10-23 neuropeptide Y Homo sapiens 46-49 17868303-7 2007 In summary, in mouse chromaffin cells, NPY evokes catecholamine release by the activation the NPY Y1 receptor, in a Ca2+-dependent manner, by activating mitogen-activated protein kinase and promoting nitric oxide production, which in turn regulates protein kinase C and guanylyl cyclase activation. Catecholamines 50-63 neuropeptide Y Mus musculus 39-42 17868303-7 2007 In summary, in mouse chromaffin cells, NPY evokes catecholamine release by the activation the NPY Y1 receptor, in a Ca2+-dependent manner, by activating mitogen-activated protein kinase and promoting nitric oxide production, which in turn regulates protein kinase C and guanylyl cyclase activation. Catecholamines 50-63 neuropeptide Y Mus musculus 94-97 17904738-6 2007 From these results, we conclude: (1) neuronal nitric oxide suppresses vasopressin expression under basal conditions and during activation of the vasopressinergic system by dehydration; (2) catecholamines limit vasopressin expression; (3) nNOS is required for the effects of catecholamines on vasopressin expression. Catecholamines 189-203 nitric oxide synthase 1, neuronal Mus musculus 238-242 17884294-1 2007 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous neuropeptide observed in adrenal gland and sympathetic ganglia to regulate catecholamine synthesis and release. Catecholamines 151-164 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-50 17884294-1 2007 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous neuropeptide observed in adrenal gland and sympathetic ganglia to regulate catecholamine synthesis and release. Catecholamines 151-164 adenylate cyclase activating polypeptide 1 Rattus norvegicus 52-57 17884294-2 2007 Both PACAP and glucocorticoid showed the activity to elevate catecholamine level through the stimulation of biosynthesis. Catecholamines 61-74 adenylate cyclase activating polypeptide 1 Rattus norvegicus 5-10 17481854-3 2007 Although both CS and CT individually can inhibit the production of T-helper 1 (TH1, type-1 like) cytokines and simultaneously promote the production of T-helper 2 (TH2, type-2 like) cytokines in antigen-specific and mitogen stimulated human leukocyte cultures in vitro, little attention has been focused on the effects of combination CT and CS in immune responses that may be more physiologically relevant. Catecholamines 21-23 negative elongation factor complex member C/D Homo sapiens 67-95 17594065-6 2007 The hemodynamic effects of AVP were comparable to those AVP-induced alterations described in septic shock and seem to be predominantly mediated by potent vasoconstriction and the facilitated reduction of higher, potentially toxic catecholamine doses. Catecholamines 230-243 arginine vasopressin Homo sapiens 27-30 17482290-4 2007 The adrenal and prevertebral ganglionic expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine production, was significantly increased in ANP -/- mice. Catecholamines 109-122 tyrosine hydroxylase Mus musculus 54-74 17482290-4 2007 The adrenal and prevertebral ganglionic expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine production, was significantly increased in ANP -/- mice. Catecholamines 109-122 natriuretic peptide type A Mus musculus 166-169 17482290-5 2007 ANP"s sympatholytic properties include the depression of ganglionic and adrenal TH expression and catecholamine production. Catecholamines 98-111 natriuretic peptide type A Mus musculus 0-3 17917852-8 2007 Increased blood glucose following CDP-choline, phosphocholine and choline was accompanied by elevated plasma catecholamine concentrations. Catecholamines 109-122 cut-like homeobox 1 Rattus norvegicus 34-37 17917852-12 2007 These data show that CDP-choline and its metabolites induce hyperglycemia which is mediated by activation of ganglionic nicotinic receptors and stimulation of catecholamine release that subsequently activates 2-adrenoceptors. Catecholamines 159-172 cut-like homeobox 1 Rattus norvegicus 21-24 17481854-5 2007 Results demonstrated a significant decrease in type-1 cytokine production (IFN-gamma) and a significant increase in type-2 cytokine production (IL-4, IL-10) in our CS+CT incubated cultures when compared to either CT or CS agents alone. Catecholamines 167-169 interleukin 4 Homo sapiens 144-148 17481854-5 2007 Results demonstrated a significant decrease in type-1 cytokine production (IFN-gamma) and a significant increase in type-2 cytokine production (IL-4, IL-10) in our CS+CT incubated cultures when compared to either CT or CS agents alone. Catecholamines 167-169 interleukin 10 Homo sapiens 150-155 17880176-2 2007 In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins). Catecholamines 283-297 catechol-O-methyltransferase Homo sapiens 88-92 17761405-1 2007 Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 0-28 17761405-1 2007 Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. Catecholamines 87-101 catechol-O-methyltransferase Homo sapiens 30-34 17606257-6 2007 In a second study immunocytochemistry was used to examine the distribution of the phosphorylated (i.e., active) form of tyrosine hydroxylase (pTH), the rate-limiting enzyme for catecholamine synthesis. Catecholamines 177-190 parathyroid hormone Sturnus vulgaris 142-145 17718510-1 2007 The secretory pro-hormone chromogranin A (CHGA) is densely packed into storage granules along with catecholamines, playing a catalytic role in granule biogenesis. Catecholamines 99-113 chromogranin A Mus musculus 26-40 17664025-1 2007 Alpha2-adrenoceptors belong to the group of nine adrenoceptors which mediate the biological actions of the endogenous catecholamines adrenaline and noradrenaline. Catecholamines 118-132 adrenergic receptor, alpha 2a Mus musculus 0-20 17828268-5 2007 Treatment with catecholamines enhanced human CD34+ cell engraftment of NOD-SCID mice through Wnt signaling activation and increased cell mobilization and bone marrow Sca-1+c-Kit+Lin- cell numbers. Catecholamines 15-29 CD34 molecule Homo sapiens 45-49 17718510-1 2007 The secretory pro-hormone chromogranin A (CHGA) is densely packed into storage granules along with catecholamines, playing a catalytic role in granule biogenesis. Catecholamines 99-113 chromogranin A Mus musculus 42-46 17924258-4 2007 An amino acid polymorphism (Val158Met) in the COMT gene affects the activity level of COMT, which affects the levels of available catecholamines in the brain. Catecholamines 130-144 catechol-O-methyltransferase Homo sapiens 46-50 17705531-0 2007 Fibrinogen-catecholamine interaction as observed by NMR and Fourier transform infrared spectroscopy. Catecholamines 11-24 fibrinogen beta chain Homo sapiens 0-10 17705531-1 2007 In this work, the interactions between the main catecholamines-epinephrine and norepinephrine-and fibrinogen were investigated by NMR and Fourier transform infrared spectroscopies. Catecholamines 48-62 fibrinogen beta chain Homo sapiens 98-108 17597596-5 2007 RESULTS: Heterozygous alpha(2C)-receptor deletion (alpha(2C)+/-) resulted in a 43% reduction of adrenal alpha(2C) mRNA copy number and in a similar decrease in alpha(2)-receptor-mediated inhibition of catecholamine release from isolated adrenal glands in vitro. Catecholamines 201-214 adrenergic receptor, alpha 2c Mus musculus 22-30 17597596-5 2007 RESULTS: Heterozygous alpha(2C)-receptor deletion (alpha(2C)+/-) resulted in a 43% reduction of adrenal alpha(2C) mRNA copy number and in a similar decrease in alpha(2)-receptor-mediated inhibition of catecholamine release from isolated adrenal glands in vitro. Catecholamines 201-214 adrenergic receptor, alpha 2c Mus musculus 51-59 17597596-5 2007 RESULTS: Heterozygous alpha(2C)-receptor deletion (alpha(2C)+/-) resulted in a 43% reduction of adrenal alpha(2C) mRNA copy number and in a similar decrease in alpha(2)-receptor-mediated inhibition of catecholamine release from isolated adrenal glands in vitro. Catecholamines 201-214 adrenergic receptor, alpha 2c Mus musculus 51-59 17713401-2 2007 Catecholamines, however, also have marked metabolic effects, particularly on glucose metabolism, and the degree of this metabolic response is directly related to the beta2-adrenoceptor activity of the individual compound used. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 166-184 17713401-3 2007 Under physiologic conditions, infusing catecholamine is associated with enhanced rates of aerobic glycolysis (resulting in adenosine triphosphate production), glucose release (both from glycogenolysis and gluconeogenesis), and inhibition of insulin-mediated glycogenesis. Catecholamines 39-52 insulin Homo sapiens 241-248 17823084-15 2007 The effects of the challenges were increased with 39 degrees C compared to 38.5 degrees C. CONCLUSIONS: Catecholamines play a major role in the mobilization of immunocompetent cells and the production of IL-10 during exercise. Catecholamines 104-118 interleukin 10 Homo sapiens 204-209 17924258-4 2007 An amino acid polymorphism (Val158Met) in the COMT gene affects the activity level of COMT, which affects the levels of available catecholamines in the brain. Catecholamines 130-144 catechol-O-methyltransferase Homo sapiens 86-90 17717598-1 2007 GTP cyclohydrolase 1 (GCH1) is rate limiting in the provision of the cofactor tetrahydrobiopterin for biosynthesis of catecholamines and NO. Catecholamines 118-132 GTP cyclohydrolase 1 Homo sapiens 0-20 17671739-6 2007 This finding, coupled with the demonstration that NPY enhanced catecholamine release from guinea pigadrenomedullary tissue, strongly suggests that NPY may stimulate glucocorticoid secretion in this species through an indirect mechanism involving catecholamines, that in a paracrine manner promote the secretion of inner adrenocortical cells. Catecholamines 63-76 pro-neuropeptide Y Cavia porcellus 50-53 17671739-6 2007 This finding, coupled with the demonstration that NPY enhanced catecholamine release from guinea pigadrenomedullary tissue, strongly suggests that NPY may stimulate glucocorticoid secretion in this species through an indirect mechanism involving catecholamines, that in a paracrine manner promote the secretion of inner adrenocortical cells. Catecholamines 63-76 pro-neuropeptide Y Cavia porcellus 147-150 17671739-6 2007 This finding, coupled with the demonstration that NPY enhanced catecholamine release from guinea pigadrenomedullary tissue, strongly suggests that NPY may stimulate glucocorticoid secretion in this species through an indirect mechanism involving catecholamines, that in a paracrine manner promote the secretion of inner adrenocortical cells. Catecholamines 246-260 pro-neuropeptide Y Cavia porcellus 147-150 17717598-1 2007 GTP cyclohydrolase 1 (GCH1) is rate limiting in the provision of the cofactor tetrahydrobiopterin for biosynthesis of catecholamines and NO. Catecholamines 118-132 GTP cyclohydrolase 1 Homo sapiens 22-26 17698732-16 2007 Catecholamine secretion is influenced by genetic variation in the adrenergic pathway encoding catecholamine synthesis, especially at the classically rate-limiting step, TH. Catecholamines 94-107 tyrosine hydroxylase Homo sapiens 169-171 17540007-2 2007 Hence, the presence of cannabinoid CB(1) receptors in tyrosine hydroxylase (TH) containing cells has been suggested, providing clue for a direct control of catecholamines synthesis. Catecholamines 156-170 tyrosine hydroxylase Mus musculus 54-74 17540007-2 2007 Hence, the presence of cannabinoid CB(1) receptors in tyrosine hydroxylase (TH) containing cells has been suggested, providing clue for a direct control of catecholamines synthesis. Catecholamines 156-170 tyrosine hydroxylase Mus musculus 76-78 17540525-7 2007 Since angiotensin II is involved in the regulation of catecholamine biosynthesis, we examined the expressions of angiotensin II receptor subtypes in the adrenal medulla. Catecholamines 54-67 angiotensinogen Rattus norvegicus 6-20 17698732-0 2007 Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Catecholamines 50-63 tyrosine hydroxylase Homo sapiens 0-20 17698732-1 2007 BACKGROUND: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 69-82 tyrosine hydroxylase Homo sapiens 12-32 17698732-1 2007 BACKGROUND: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 69-82 tyrosine hydroxylase Homo sapiens 34-36 17698732-11 2007 In the TH promoter, significant associations were found for urinary catecholamine excretion and for blood pressure response to stress. Catecholamines 68-81 tyrosine hydroxylase Homo sapiens 7-9 17698732-16 2007 Catecholamine secretion is influenced by genetic variation in the adrenergic pathway encoding catecholamine synthesis, especially at the classically rate-limiting step, TH. Catecholamines 0-13 tyrosine hydroxylase Homo sapiens 169-171 17363078-3 2007 As tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, the aim of the present work was to investigate the effects of ET-1 and ET-3 on TH activity, total enzyme level and the phosphorylated forms of TH in the rat posterior hypothalamus. Catecholamines 60-73 tyrosine hydroxylase Rattus norvegicus 3-23 17363078-3 2007 As tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, the aim of the present work was to investigate the effects of ET-1 and ET-3 on TH activity, total enzyme level and the phosphorylated forms of TH in the rat posterior hypothalamus. Catecholamines 60-73 tyrosine hydroxylase Rattus norvegicus 25-27 17574233-9 2007 Our results suggest that upregulation of TNF-alpha and downregulation of adiponectin by beta-adrenoceptor activation may contribute to the pathogenesis of catecholamine-induced insulin resistance, and that upregulation of adiponectin receptor 2 may be a feedback result of reduced adiponectin. Catecholamines 155-168 tumor necrosis factor Mus musculus 41-50 17574233-9 2007 Our results suggest that upregulation of TNF-alpha and downregulation of adiponectin by beta-adrenoceptor activation may contribute to the pathogenesis of catecholamine-induced insulin resistance, and that upregulation of adiponectin receptor 2 may be a feedback result of reduced adiponectin. Catecholamines 155-168 adiponectin, C1Q and collagen domain containing Mus musculus 73-84 17585895-2 2007 Specifically, Punch (Pu) and pale (ple) mutants with reduced dopamine synthesis show ectopic/aberrant migration, while Catecholamines up (Catsup) mutants that over-express dopamine show a characteristic loss of migration phenotype. Catecholamines 119-133 Catecholamines up Drosophila melanogaster 138-144 17599006-3 2007 RECENT FINDINGS: Examples of types of shock resistant to catecholamine pressors in which exogenous vasopressin was effective in restoring arterial pressure continued to accumulate. Catecholamines 57-70 arginine vasopressin Homo sapiens 99-110 17599007-3 2007 The vasoactive properties of vasopressin have been more applicable clinically because of the discovery by Landry and colleagues that there is a deficiency of vasopressin in septic shock and that infusion of relatively low doses of vasopressin improves responsiveness to infused catecholamines (such as norepinephrine). Catecholamines 278-292 arginine vasopressin Homo sapiens 29-40 17540525-10 2007 These data indicate that a small decrease in daily food intake can avert age-related changes in catecholamine biosynthetic enzyme levels in the adrenal medulla and hypothalamus, possibly through affecting angiotensin II signaling. Catecholamines 96-109 angiotensinogen Rattus norvegicus 205-219 17524356-1 2007 Multiple mechanisms regulate the expression of the tyrosine hydroxylase (Th) gene, which encodes the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 145-159 tyrosine hydroxylase Rattus norvegicus 51-71 17436196-8 2007 In conclusion, the stimulation of AChE and Na (+),K (+)-ATPase by the training may be due to the rise of blood catecholamine oxidation contributing to TAS decrease and/or the increase of serotonin levels. Catecholamines 111-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 17216203-1 2007 Renalase, a novel flavin adenine dinucleotide-dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and systemic blood pressure (BP). Catecholamines 119-133 renalase, FAD dependent amine oxidase Homo sapiens 0-8 17655754-1 2007 BACKGROUND: HIF2alpha/EPAS1 is a hypoxia-inducible transcription factor involved in catecholamine homeostasis, vascular remodelling, physiological angiogenesis and adipogenesis. Catecholamines 84-97 endothelial PAS domain protein 1 Mus musculus 12-21 17655754-1 2007 BACKGROUND: HIF2alpha/EPAS1 is a hypoxia-inducible transcription factor involved in catecholamine homeostasis, vascular remodelling, physiological angiogenesis and adipogenesis. Catecholamines 84-97 endothelial PAS domain protein 1 Mus musculus 22-27 17524356-1 2007 Multiple mechanisms regulate the expression of the tyrosine hydroxylase (Th) gene, which encodes the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 145-159 tyrosine hydroxylase Rattus norvegicus 73-75 17541557-0 2007 In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism. Catecholamines 73-86 adrenoceptor beta 1 Homo sapiens 164-183 17607358-1 2007 Catecholamine-induced polymorphic ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations. Catecholamines 0-13 ryanodine receptor 2, cardiac Mus musculus 133-137 17607358-1 2007 Catecholamine-induced polymorphic ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations. Catecholamines 0-13 calsequestrin 2 Mus musculus 142-157 17607358-1 2007 Catecholamine-induced polymorphic ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations. Catecholamines 0-13 calsequestrin 2 Mus musculus 159-164 17620104-0 2007 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells. Catecholamines 100-113 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 141-169 17620104-14 2007 These findings indicate that AICAR activates catecholamine synthesis and secretion through AMPK activation in chromaffin cells. Catecholamines 45-58 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 91-95 17565281-1 2007 PURPOSE OF REVIEW: Renalase is a secreted amine oxidase that metabolizes catecholamines. Catecholamines 73-87 renalase, FAD dependent amine oxidase Homo sapiens 19-27 17565281-4 2007 Parenteral administration of either native or recombinant renalase lowers blood pressure and heart rate by metabolizing circulating catecholamines. Catecholamines 132-146 renalase, FAD dependent amine oxidase Homo sapiens 58-66 17565281-9 2007 SUMMARY: The renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, and, therefore, cardiac function, and blood pressure. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 13-21 17419009-1 2007 The Val158Met polymorphism of the COMT gene is functional, easily detectable, and significantly related to metabolism of catecholamines, which underlie pathogenesis of a significant number of mental disorders. Catecholamines 121-135 catechol-O-methyltransferase Homo sapiens 34-38 17449848-8 2007 Synaptotagmin 7 C2B domain inhibited catecholamine release from digitonin-permeabilized chromaffin cells, and this inhibition was abrogated with the C2B polylysine mutant. Catecholamines 37-50 synaptotagmin 7 Rattus norvegicus 0-15 17541557-3 2007 The aim of this study was to find out whether the Arg389Gly-beta(1)AR polymorphism might also determine demand of catecholamine-induced inotropic support in patients with low cardiac index (CI) after coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). Catecholamines 114-127 adrenoceptor beta 1 Homo sapiens 60-69 17541557-8 2007 We conclude that the Arg389Gly-beta(1)AR polymorphism appears to be a determinant of cardiac responses to catecholamine stimulation. Catecholamines 106-119 adrenoceptor beta 1 Homo sapiens 31-40 17327373-10 2007 HSL knock down by RNAi reduced basal and catecholamine-induced lipolysis. Catecholamines 41-54 lipase E, hormone sensitive type Homo sapiens 0-3 17360248-4 2007 SDHD +/- mice had, however, a clear CB phenotype characterized by a decrease of K(+) current amplitude, an increase of basal catecholamine release from glomus cells, and a slight organ growth. Catecholamines 125-138 succinate dehydrogenase complex, subunit D, integral membrane protein Mus musculus 0-4 17498763-5 2007 Nicotine also significantly upregulated the expression of the catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine N-methyltransferase]. Catecholamines 62-75 dopamine beta-hydroxylase Homo sapiens 125-150 17482701-1 2007 Catechol-O-methyltransferase (COMT) is one of the enzymes that degrade catecholamine neurotransmitters including dopamine. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 0-28 17482701-1 2007 Catechol-O-methyltransferase (COMT) is one of the enzymes that degrade catecholamine neurotransmitters including dopamine. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 30-34 17327373-13 2007 In contrast to findings in rodents, ATGL is of less importance than HSL in regulating catecholamine-induced lipolysis and cannot replace HSL when this enzyme is continuously inhibited. Catecholamines 86-99 patatin like phospholipase domain containing 2 Homo sapiens 36-40 17401441-0 2007 Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation. Catecholamines 0-13 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 76-108 17503329-6 2007 In human fat cells, GPR74 receptor stimulation and inhibition caused a significant and marked decrease and increase, respectively, of lipolysis, which could be linked to catecholamine stimulation of adipocytes through beta -adrenergic receptors. Catecholamines 170-183 neuropeptide FF receptor 2 Homo sapiens 20-25 17401441-1 2007 BACKGROUND AND PURPOSE: Mice with targeted deletions of neuronal nicotinic acetylcholine receptor (nAChR) subunit genes are valuable models to study nAChR function such as catecholamine outflow by presynaptic receptor activation. Catecholamines 172-185 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 65-97 17401441-1 2007 BACKGROUND AND PURPOSE: Mice with targeted deletions of neuronal nicotinic acetylcholine receptor (nAChR) subunit genes are valuable models to study nAChR function such as catecholamine outflow by presynaptic receptor activation. Catecholamines 172-185 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 99-104 17401441-9 2007 CONCLUSIONS AND IMPLICATIONS: Targeted deletion of the beta2 subunit gene essentially abolished the effect of nicotine, indicating that this subunit is an essential constituent of nAChRs that indirectly (via action potentials) induce catecholamine release from hippocampal and striatal slices in mice. Catecholamines 234-247 hemoglobin, beta adult minor chain Mus musculus 55-60 17457889-1 2007 Catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme. Catecholamines 0-14 tyrosine hydroxylase Mus musculus 110-130 17261361-1 2007 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine synthesis. Catecholamines 57-70 tyrosine hydroxylase Bos taurus 0-20 17261361-1 2007 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine synthesis. Catecholamines 57-70 tyrosine hydroxylase Bos taurus 22-24 17261361-10 2007 The sustained activation of TH that occurred as a result of TH phosphorylation at Ser40 could maintain the synthesis of catecholamines without the need for further stimulus of the adrenal cells or increased TH protein synthesis. Catecholamines 120-134 tyrosine hydroxylase Bos taurus 28-30 17261361-10 2007 The sustained activation of TH that occurred as a result of TH phosphorylation at Ser40 could maintain the synthesis of catecholamines without the need for further stimulus of the adrenal cells or increased TH protein synthesis. Catecholamines 120-134 tyrosine hydroxylase Bos taurus 60-62 17261361-10 2007 The sustained activation of TH that occurred as a result of TH phosphorylation at Ser40 could maintain the synthesis of catecholamines without the need for further stimulus of the adrenal cells or increased TH protein synthesis. Catecholamines 120-134 tyrosine hydroxylase Bos taurus 60-62 17457889-1 2007 Catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme. Catecholamines 0-14 tyrosine hydroxylase Mus musculus 132-134 17428548-5 2007 Using FACS analysis and confocal microscopy, we report the expression of alpha1-, alpha2- and beta(2)-AR in enriched populations of ER-MP209(+) and ER-MP12(+) myeloid progenitors, CD117(+) and CD34(+) multi-potential progenitors and more importantly pluripotent stem cells suggesting a plausible role for catecholamine in hematopoietic development. Catecholamines 305-318 adrenergic receptor, beta 2 Mus musculus 73-104 17514580-1 2007 This review summarizes knowledge on the effects of stress on two catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 65-78 tyrosine hydroxylase Homo sapiens 101-121 17514580-1 2007 This review summarizes knowledge on the effects of stress on two catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 65-78 tyrosine hydroxylase Homo sapiens 123-125 17514580-1 2007 This review summarizes knowledge on the effects of stress on two catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 65-78 phenylethanolamine N-methyltransferase Homo sapiens 131-169 17514580-1 2007 This review summarizes knowledge on the effects of stress on two catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT). Catecholamines 65-78 phenylethanolamine N-methyltransferase Homo sapiens 171-175 17514586-4 2007 This review summarizes current knowledge on catecholamine production in the heart, with special focus on the final enzyme in the catecholamine synthesizing pathway, phenylethanolamine N-methyltransferase (PNMT), in different cell types in the heart. Catecholamines 129-142 phenylethanolamine N-methyltransferase Homo sapiens 165-203 17303681-9 2007 The levels of catecholamines were slightly elevated after TGF-beta administration, and, although not significantly in statistical terms, we consider that at least a part of TGF-beta signal was transducted via the sympathetic nervous system because of these increases. Catecholamines 14-28 transforming growth factor, beta 1 Rattus norvegicus 58-66 17303681-9 2007 The levels of catecholamines were slightly elevated after TGF-beta administration, and, although not significantly in statistical terms, we consider that at least a part of TGF-beta signal was transducted via the sympathetic nervous system because of these increases. Catecholamines 14-28 transforming growth factor, beta 1 Rattus norvegicus 173-181 17438153-3 2007 Chromogranin A (CHGA) regulates the storage and release of catecholamines and may have direct actions on the microvasculature. Catecholamines 59-73 chromogranin A Homo sapiens 0-14 17438153-3 2007 Chromogranin A (CHGA) regulates the storage and release of catecholamines and may have direct actions on the microvasculature. Catecholamines 59-73 chromogranin A Homo sapiens 16-20 17438154-1 2007 BACKGROUND: Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. Catecholamines 44-58 chromogranin A Homo sapiens 12-26 17438154-1 2007 BACKGROUND: Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. Catecholamines 44-58 chromogranin A Homo sapiens 134-144 17438154-1 2007 BACKGROUND: Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. Catecholamines 44-57 chromogranin A Homo sapiens 12-26 17438154-1 2007 BACKGROUND: Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. Catecholamines 44-57 chromogranin A Homo sapiens 134-144 17557938-1 2007 Catecholamines, endothelin-1 and angiotensin II are among a diverse group of diffusible extracellular signals that regulate pump function of the heart by binding to G-protein coupled receptors (GPCR). Catecholamines 0-14 vomeronasal 1 receptor 17 pseudogene Homo sapiens 165-192 17557938-1 2007 Catecholamines, endothelin-1 and angiotensin II are among a diverse group of diffusible extracellular signals that regulate pump function of the heart by binding to G-protein coupled receptors (GPCR). Catecholamines 0-14 vomeronasal 1 receptor 17 pseudogene Homo sapiens 194-198 17220188-12 2007 These data suggest that catecholamine stimulation of alpha(1B)- and alpha(1D)-ARs contributes significantly to vascular remodeling in hypoxic PH. Catecholamines 24-37 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 53-61 17306579-1 2007 Chromogranin A (CgA), one component of the granin family, represents the major soluble protein co-stored and co-released with catecholamines, within chromaffin cells secretory granules. Catecholamines 126-140 chromogranin A Rattus norvegicus 0-14 17306579-1 2007 Chromogranin A (CgA), one component of the granin family, represents the major soluble protein co-stored and co-released with catecholamines, within chromaffin cells secretory granules. Catecholamines 126-140 chromogranin A Rattus norvegicus 16-19 17587758-1 2007 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 66-80 catechol-O-methyltransferase Rattus norvegicus 0-28 17587758-1 2007 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 66-80 catechol-O-methyltransferase Rattus norvegicus 30-34 17470513-3 2007 This study examined influences of hereditary factors and differences in catecholamine production on tumour expression of NPY, as assessed by quantitative PCR, enzyme immunoassay and immunohistochemistry. Catecholamines 72-85 neuropeptide Y Homo sapiens 121-124 17148758-2 2007 We report here that in CD1 mice there is marked sexual dimorphism affecting not only gland size and corticoid hormone secretion but also adrenal ornithine decarboxylase (ODC), polyamine, and catecholamine levels in which testosterone appears to be a major determinant. Catecholamines 191-204 CD1 antigen complex Mus musculus 23-26 16937359-0 2007 The prognostic role of urinary catecholamines in infants with disseminated neuroblastoma may be mediated by MYCN amplification. Catecholamines 31-45 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 108-112 17386959-7 2007 Increases in blood pressure, heart rate and circulating catecholamines were all greater in response to central AM2 than to AM at the same dose. Catecholamines 56-70 adrenomedullin 2 Rattus norvegicus 111-114 17413940-0 2007 Use of vasopressin bolus and infusion to treat catecholamine-resistant hypotension during pheochromocytoma resection. Catecholamines 47-60 arginine vasopressin Homo sapiens 7-18 17371283-7 2007 Studies in catecholamine-depleted kidneys point to a synergistic interaction between the signalling pathways activated via cell membrane catecholamine receptors and AR, as well as c-Met. Catecholamines 11-24 androgen receptor Mus musculus 165-167 17371283-7 2007 Studies in catecholamine-depleted kidneys point to a synergistic interaction between the signalling pathways activated via cell membrane catecholamine receptors and AR, as well as c-Met. Catecholamines 11-24 met proto-oncogene Mus musculus 180-185 17148758-7 2007 Combination treatment of mice with alpha-difluoromethylornithine (a suicide inhibitor of ODC) and a polyamine-deficient diet produced a marked decrease in adrenal polyamine and catecholamine levels and a significant reduction in plasma corticosterone and aldosterone concentrations that were not associated with a decrease in the mRNA levels of steroidogenic proteins. Catecholamines 177-190 ornithine decarboxylase, structural 1 Mus musculus 89-92 17624234-2 2007 In septic adults, vasopressin-terlipressin have been shown to increase mean arterial pressure and to decrease the necessity for catecholamines. Catecholamines 128-142 arginine vasopressin Homo sapiens 18-29 17194738-0 2007 Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner. Catecholamines 80-93 corticotropin releasing hormone Homo sapiens 0-30 17194738-1 2007 Corticotropin-releasing factor (CRF) affects catecholamine production both centrally and peripherally. Catecholamines 45-58 corticotropin releasing hormone Rattus norvegicus 0-30 17194738-4 2007 Exposure of dispersed human and rat adrenal chromaffin cells to CRF1 receptor agonists induced catecholamine secretion in a dose-dependent manner, an effect peaking at 30 min, whereas CRF2 receptor agonists suppressed catecholamine secretion. Catecholamines 95-108 corticotropin releasing hormone receptor 1 Homo sapiens 64-68 17194738-4 2007 Exposure of dispersed human and rat adrenal chromaffin cells to CRF1 receptor agonists induced catecholamine secretion in a dose-dependent manner, an effect peaking at 30 min, whereas CRF2 receptor agonists suppressed catecholamine secretion. Catecholamines 218-231 corticotropin releasing hormone receptor 1 Homo sapiens 64-68 17194738-4 2007 Exposure of dispersed human and rat adrenal chromaffin cells to CRF1 receptor agonists induced catecholamine secretion in a dose-dependent manner, an effect peaking at 30 min, whereas CRF2 receptor agonists suppressed catecholamine secretion. Catecholamines 218-231 corticotropin releasing hormone receptor 2 Homo sapiens 184-188 17194738-8 2007 In rat chromaffin and PC12 cells, CRF1 and CRF2 agonists induced catecholamine synthesis via tyrosine hydroxylase. Catecholamines 65-78 corticotropin releasing hormone receptor 1 Rattus norvegicus 34-38 17194738-8 2007 In rat chromaffin and PC12 cells, CRF1 and CRF2 agonists induced catecholamine synthesis via tyrosine hydroxylase. Catecholamines 65-78 corticotropin releasing hormone receptor 2 Rattus norvegicus 43-47 17194738-10 2007 In conclusion, it appears that a complex intraadrenal CRF-UCN/CRF-receptor system exists in both human and rat adrenals controlling catecholamine secretion and synthesis. Catecholamines 132-145 urocortin Homo sapiens 58-61 17806174-0 2007 Novel ligands stabilize stereo-selective conformations of the histamine H1 receptor to activate catecholamine synthesis. Catecholamines 96-109 histamine receptor H1 Homo sapiens 62-83 17251187-1 2007 Catecholamine stimulation of beta-adrenergic receptors (betaAR) in adipocytes activates the cAMP-dependent protein kinase to promote liberation of fatty acids as a fuel source. Catecholamines 0-13 adrenoceptor beta 3 Homo sapiens 56-62 17226783-8 2007 We propose that the mechanism for the pro-motogenic effect of the beta-adrenergic antagonist is blockade of the beta2-adrenergic receptor preventing autocrine catecholamine binding. Catecholamines 159-172 adrenoceptor beta 2 Homo sapiens 112-137 17084978-1 2007 Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 0-28 17084978-1 2007 Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 30-34 17084978-5 2007 To characterize the means whereby elevated catecholamine levels, resulting from reduced COMT activity, modulate heightened pain sensitivity, we administered a COMT inhibitor to rats and measured behavioral responsiveness to mechanical and thermal stimuli. Catecholamines 43-56 catechol-O-methyltransferase Rattus norvegicus 88-92 17084978-5 2007 To characterize the means whereby elevated catecholamine levels, resulting from reduced COMT activity, modulate heightened pain sensitivity, we administered a COMT inhibitor to rats and measured behavioral responsiveness to mechanical and thermal stimuli. Catecholamines 43-56 catechol-O-methyltransferase Rattus norvegicus 159-163 17227803-6 2007 CONCLUSION: SDHD mutations (D92Y) are associated with malignant paragangliomas and catecholamine excess with remarkable interindividual variations despite the same mutation. Catecholamines 83-96 succinate dehydrogenase complex subunit D Homo sapiens 12-16 17351367-2 2007 A deletion polymorphism in its gene (ADRA2C del322-325), ten times more common in black than white Americans, has been associated with a loss of function in vitro and, under controlled study conditions, raised blood pressure and catecholamine secretion. Catecholamines 229-242 adrenoceptor alpha 2C Homo sapiens 37-43 17259807-5 2007 The opioids stimulate the hypothalamus-pituitary-adrenal axis and sympathetic and adrenomedullary system, through the activation of mu-opioid receptor (MOR) to release stress hormones, such as cortisol and catecholamines, respectively. Catecholamines 206-220 opioid receptor, mu 1 Mus musculus 132-150 17259807-5 2007 The opioids stimulate the hypothalamus-pituitary-adrenal axis and sympathetic and adrenomedullary system, through the activation of mu-opioid receptor (MOR) to release stress hormones, such as cortisol and catecholamines, respectively. Catecholamines 206-220 opioid receptor, mu 1 Mus musculus 152-155 20409839-9 2007 These results identify renalase as a novel renal hormone that modulates cardiac function and systemic blood pressure by regulating catecholamine levels. Catecholamines 131-144 renalase, FAD dependent amine oxidase Homo sapiens 23-31 17122078-2 2007 We previously reported that male mice with a dominant-negative P398H mutation introduced into the TRalpha gene have visceral obesity, hyperleptinemia, and reduced catecholamine-stimulated lipolysis in white adipose tissue. Catecholamines 163-176 guanine nucleotide binding protein, alpha transducing 1 Mus musculus 98-105 20409839-7 2007 In vitro studies indicate that renalase is a novel amine oxidase that specifically metabolizes circulating catecholamines including epinephrine and norepinephrine. Catecholamines 107-121 renalase, FAD dependent amine oxidase Homo sapiens 31-39 17199132-1 2007 The beta2-adrenergic receptor is part of the catecholamine system, and variants at two polymorphic sites in the gene coding for the receptor (ADRB2) confer increased activity. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 4-29 17164411-3 2007 CAPS1 regulates catecholamine release from neuroendocrine cells, whereas CAPS2 is involved in the release of brain-derived neurotrophic factor and neurotrophin-3 from cerebellar granule cells. Catecholamines 16-29 Ca2+-dependent secretion activator Mus musculus 0-5 17200167-17 2007 CONCLUSIONS: SDHB-related PGL often presents as apparently sporadic PGL with symptoms related to tumor mass effect rather than to catecholamine excess. Catecholamines 130-143 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 13-17 17199132-1 2007 The beta2-adrenergic receptor is part of the catecholamine system, and variants at two polymorphic sites in the gene coding for the receptor (ADRB2) confer increased activity. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 142-147 17270273-10 2007 The implications of inhibition of P450-catalzyed oxidation steps that are known or speculated to influence arachadonic acid, cholesterol, and catecholamine neurotransmitters pathways in human brain will be considered. Catecholamines 142-155 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 34-38 17324261-3 2007 METHODS: The following study examined if exogenous Sry would elevate adrenal Th, adrenal catecholamines, plasma catecholamines and blood pressure. Catecholamines 89-103 sex determining region Y Rattus norvegicus 51-54 17360665-4 2007 Sympathoadrenal function is disrupted in these mice, which reflects control of enzymes relevant to both synthesis (phenylethanolamine N-methyl transferase) and disposition (monoamine oxidase B and catechol-O-methyl transferase) of catecholamines by the clock. Catecholamines 231-245 monoamine oxidase B Mus musculus 173-192 17324261-3 2007 METHODS: The following study examined if exogenous Sry would elevate adrenal Th, adrenal catecholamines, plasma catecholamines and blood pressure. Catecholamines 112-126 sex determining region Y Rattus norvegicus 51-54 17360665-4 2007 Sympathoadrenal function is disrupted in these mice, which reflects control of enzymes relevant to both synthesis (phenylethanolamine N-methyl transferase) and disposition (monoamine oxidase B and catechol-O-methyl transferase) of catecholamines by the clock. Catecholamines 231-245 catechol-O-methyltransferase Mus musculus 197-226 17198676-5 2007 Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin and catecholamines may contribute to altered regulation of metabolism in diabetes. Catecholamines 90-104 phosphodiesterase 3B, cGMP-inhibited Mus musculus 22-27 17360665-4 2007 Sympathoadrenal function is disrupted in these mice, which reflects control of enzymes relevant to both synthesis (phenylethanolamine N-methyl transferase) and disposition (monoamine oxidase B and catechol-O-methyl transferase) of catecholamines by the clock. Catecholamines 231-245 circadian locomotor output cycles kaput Mus musculus 253-258 17360665-6 2007 Despite diurnal variation of catecholamines and corticosteroids, they are regulated differentially by the molecular clock. Catecholamines 29-43 circadian locomotor output cycles kaput Mus musculus 116-121 17198676-5 2007 Altered expression of PDE3B and PDE4D in response to long-term treatment with insulin and catecholamines may contribute to altered regulation of metabolism in diabetes. Catecholamines 90-104 phosphodiesterase 4D, cAMP specific Mus musculus 32-37 17265038-2 2007 In the irreversible phase of hemorrhagic shock that was unresponsive to volume replacement, airway management and catecholamines, vasopressin was beneficial due to an increase in arterial blood pressure, shift of blood away from a subdiaphragmatic bleeding site towards the heart and brain and decrease of fluid resuscitation requirements. Catecholamines 114-128 arginine vasopressin Homo sapiens 130-141 17240060-4 2007 Of particular interest was catechol-O-methyl transferase (COMT), an enzyme involved in metabolizing catecholamines released following neuronal activity. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 27-56 17240060-4 2007 Of particular interest was catechol-O-methyl transferase (COMT), an enzyme involved in metabolizing catecholamines released following neuronal activity. Catecholamines 100-114 catechol-O-methyltransferase Homo sapiens 58-62 17240060-8 2007 Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas. Catecholamines 111-124 solute carrier family 6 member 3 Homo sapiens 6-26 17240060-8 2007 Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas. Catecholamines 111-124 catechol-O-methyltransferase Homo sapiens 97-101 17240060-8 2007 Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas. Catecholamines 182-195 solute carrier family 6 member 3 Homo sapiens 6-26 17240060-8 2007 Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas. Catecholamines 182-195 catechol-O-methyltransferase Homo sapiens 97-101 17322894-5 2007 Adrenal gland-specific GRK2 inhibition reversed alpha2AR dysregulation in heart failure, resulting in lowered plasma catecholamine levels, improved cardiac betaAR signaling and function, and increased sympatholytic efficacy of a alpha2AR agonist. Catecholamines 117-130 G protein-coupled receptor kinase 2 Homo sapiens 23-27 17174279-2 2007 Our previous work illustrated gradual accumulation of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis and the neuropeptide transmitter proenkephalin (ppEnk) in butyrate-differentiated PC12 cells (Nankova, B.B., Chua, J., Mishra, R., Kobasiuk, C.D., La Gamma, E.F. 2003. Catecholamines 118-131 tyrosine hydroxylase Rattus norvegicus 63-83 17174279-2 2007 Our previous work illustrated gradual accumulation of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis and the neuropeptide transmitter proenkephalin (ppEnk) in butyrate-differentiated PC12 cells (Nankova, B.B., Chua, J., Mishra, R., Kobasiuk, C.D., La Gamma, E.F. 2003. Catecholamines 118-131 tyrosine hydroxylase Rattus norvegicus 85-87 17174279-14 2007 We speculate that, depending on plasma concentrations of butyrate, this naturally occurring signaling molecule can function as an in vivo molecular switch to alter levels of TH mRNA, its protein and thus the biosynthesis of endogenous catecholamines. Catecholamines 235-249 tyrosine hydroxylase Rattus norvegicus 174-176 16951930-1 2007 Spontaneous activity of specific regions (e.g., the Sinoatrial node, SAN) is essential for the normal activation sequence of the heart and also serve as a primary means of modulating cardiac rate by sympathetic tone and circulating catecholamines. Catecholamines 232-246 N-alpha-acetyltransferase 50, NatE catalytic subunit Homo sapiens 69-72 17154257-7 2007 PACAP-containing cell groups were found to be retrogradely labeled from the PVN in the median preoptic nucleus; preoptic and lateral hypothalamic areas; arcuate, dorsomedial, ventromedial, and supramammillary nuclei; ventrolateral midbrain periaqueductal gray; rostral and midlevel ventrolateral medulla, including the C1 catecholamine cell group; nucleus of the solitary tract; and dorsal motor nucleus of vagus. Catecholamines 322-335 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 17211240-12 2007 Plasma CRP concentration in twins was predicted by polymorphisms at three loci in physiological series within the catecholamine biosynthetic/beta-adrenergic pathway: TH (tyrosine hydroxylase), ADRB1 (beta1-adrenergic receptor) and ADRB2 (beta2-adrenergic receptor). Catecholamines 114-127 C-reactive protein Homo sapiens 7-10 17211240-12 2007 Plasma CRP concentration in twins was predicted by polymorphisms at three loci in physiological series within the catecholamine biosynthetic/beta-adrenergic pathway: TH (tyrosine hydroxylase), ADRB1 (beta1-adrenergic receptor) and ADRB2 (beta2-adrenergic receptor). Catecholamines 114-127 adrenoceptor beta 1 Homo sapiens 200-225 17211240-12 2007 Plasma CRP concentration in twins was predicted by polymorphisms at three loci in physiological series within the catecholamine biosynthetic/beta-adrenergic pathway: TH (tyrosine hydroxylase), ADRB1 (beta1-adrenergic receptor) and ADRB2 (beta2-adrenergic receptor). Catecholamines 114-127 adrenoceptor beta 2 Homo sapiens 231-236 17211240-12 2007 Plasma CRP concentration in twins was predicted by polymorphisms at three loci in physiological series within the catecholamine biosynthetic/beta-adrenergic pathway: TH (tyrosine hydroxylase), ADRB1 (beta1-adrenergic receptor) and ADRB2 (beta2-adrenergic receptor). Catecholamines 114-127 adrenoceptor beta 2 Homo sapiens 238-263 17194504-11 2007 This finding indicates enhanced NPY release during portal hypertension that may represent a compensatory mechanism aimed at counterbalancing arterial vasodilation by restoring the efficacy of endogenous catecholamines and inhibiting vasodilative drive in the splanchnic circulation. Catecholamines 203-217 neuropeptide Y Rattus norvegicus 32-35 17207896-0 2007 Neuropeptide Y regulates catecholamine release evoked by interleukin-1beta in mouse chromaffin cells. Catecholamines 25-38 neuropeptide Y Mus musculus 0-14 17207896-0 2007 Neuropeptide Y regulates catecholamine release evoked by interleukin-1beta in mouse chromaffin cells. Catecholamines 25-38 interleukin 1 beta Mus musculus 57-74 16985181-0 2007 Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop. Catecholamines 99-113 CD4 molecule Homo sapiens 6-9 17207896-4 2007 The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture. Catecholamines 90-103 neuropeptide Y Mus musculus 70-73 17207896-4 2007 The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture. Catecholamines 90-103 interleukin 1 beta Mus musculus 78-86 17207896-7 2007 The immunoneutralization of NPY and the use of the NPY Y(1) receptor antagonist (BIBP 3226) inhibited the stimulatory effect of IL-1beta on catecholamine release from these cells. Catecholamines 140-153 neuropeptide Y Mus musculus 28-31 17207896-7 2007 The immunoneutralization of NPY and the use of the NPY Y(1) receptor antagonist (BIBP 3226) inhibited the stimulatory effect of IL-1beta on catecholamine release from these cells. Catecholamines 140-153 neuropeptide Y Mus musculus 51-54 17207896-7 2007 The immunoneutralization of NPY and the use of the NPY Y(1) receptor antagonist (BIBP 3226) inhibited the stimulatory effect of IL-1beta on catecholamine release from these cells. Catecholamines 140-153 interleukin 1 beta Mus musculus 128-136 17207896-8 2007 The present work shows that IL-1beta induces catecholamine release, and in turn this peptide will induce an additional increase in catecholamine release acting through the Y(1) receptor. Catecholamines 45-58 interleukin 1 beta Mus musculus 28-36 17207896-8 2007 The present work shows that IL-1beta induces catecholamine release, and in turn this peptide will induce an additional increase in catecholamine release acting through the Y(1) receptor. Catecholamines 131-144 interleukin 1 beta Mus musculus 28-36 17263970-11 2007 CONCLUSIONS: These data suggest that GSK3beta inhibition may be a novel strategy to treat pheochromocytoma and other catecholamine-producing neoplasms. Catecholamines 117-130 glycogen synthase kinase 3 beta Rattus norvegicus 37-45 17156758-1 2007 A subpopulation of neurons in the rat superior cervical ganglion (SCG) was found to lack immunostaining for VMAT2, an isoform of the vesicular monoamine transporter that loads catecholamines into vesicles for release at the synapse. Catecholamines 176-190 solute carrier family 18 member A2 Rattus norvegicus 108-113 16985181-2 2007 Here, we show that human Tregs constitutively express tyrosine hydroxylase (TH, EC 1.14.16.2), the rate-limiting enzyme in the synthesis of catecholamines, and contain substantial amounts of dopamine, norepinephrine, and epinephrine, which are released upon treatment with reserpine. Catecholamines 140-154 tyrosine hydroxylase Homo sapiens 54-74 16985181-3 2007 Catecholamine release results in reduced production of interleukin-10 and transforming growth factor-beta by Tregs, and in down-regulation of Treg-dependent inhibition of effector T-lymphocyte (Teff) proliferation, which occurs without affecting the production of tumor necrosis factor-alpha or interferon-gamma. Catecholamines 0-13 interleukin 10 Homo sapiens 55-69 16985181-3 2007 Catecholamine release results in reduced production of interleukin-10 and transforming growth factor-beta by Tregs, and in down-regulation of Treg-dependent inhibition of effector T-lymphocyte (Teff) proliferation, which occurs without affecting the production of tumor necrosis factor-alpha or interferon-gamma. Catecholamines 0-13 tumor necrosis factor Homo sapiens 264-291 16985181-3 2007 Catecholamine release results in reduced production of interleukin-10 and transforming growth factor-beta by Tregs, and in down-regulation of Treg-dependent inhibition of effector T-lymphocyte (Teff) proliferation, which occurs without affecting the production of tumor necrosis factor-alpha or interferon-gamma. Catecholamines 0-13 interferon gamma Homo sapiens 295-311 17961261-4 2007 Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 0-28 17953472-6 2007 The up-regulation of iNOS transcription and overproduction of NO have been implicated in the pathogenesis of shock states where excess NO is thought to cause catecholamine resistant vasodilatation and reduced myocardial inotropy, resulting in hypotension and a fall in cardiac output. Catecholamines 158-171 nitric oxide synthase 2 Homo sapiens 21-25 17961261-4 2007 Catechol-O-methyltransferase (COMT), an enzyme, is the major catecholamine-clearing pathway. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 30-34 17961261-5 2007 There are several single-nucleotide polymorphisms (SNPs) in the COMT gene associated with the different catecholamine-clearing abilities of the COMT enzyme. Catecholamines 104-117 catechol-O-methyltransferase Homo sapiens 64-68 17961261-5 2007 There are several single-nucleotide polymorphisms (SNPs) in the COMT gene associated with the different catecholamine-clearing abilities of the COMT enzyme. Catecholamines 104-117 catechol-O-methyltransferase Homo sapiens 144-148 17029700-6 2007 Cytokines, oxygen-radicals, and catecholamines can influence the responsiveness of G-protein coupled receptors via decreasing the intracellular level of so-called G-protein coupled receptor kinases, of which the subtype GRK2 is highly expressed in immune cells. Catecholamines 32-46 G protein-coupled receptor kinase 2 Homo sapiens 220-224 17430174-5 2007 At fasting states, PACAP on the one hand promotes feeding behavior by activating neuropeptide Y neurons in the hypothalamic feeding center, arcuate nucleus, and on the other hand stimulates secretion of catecholamine and glucagon and thereby induces lipolysis in adipocytes and glucose output from liver. Catecholamines 203-216 adenylate cyclase activating polypeptide 1 Homo sapiens 19-24 18466599-1 2007 The COMT and DBH genes are physically located at chromosomes 22q11 and 9q34, respectively, and both COMT and DBH are involved in catecholamine metabolism and are strong candidates for certain psychiatric and neurological disorders. Catecholamines 129-142 catechol-O-methyltransferase Homo sapiens 4-8 18466599-1 2007 The COMT and DBH genes are physically located at chromosomes 22q11 and 9q34, respectively, and both COMT and DBH are involved in catecholamine metabolism and are strong candidates for certain psychiatric and neurological disorders. Catecholamines 129-142 dopamine beta-hydroxylase Homo sapiens 13-16 18466599-1 2007 The COMT and DBH genes are physically located at chromosomes 22q11 and 9q34, respectively, and both COMT and DBH are involved in catecholamine metabolism and are strong candidates for certain psychiatric and neurological disorders. Catecholamines 129-142 catechol-O-methyltransferase Homo sapiens 100-104 18466599-1 2007 The COMT and DBH genes are physically located at chromosomes 22q11 and 9q34, respectively, and both COMT and DBH are involved in catecholamine metabolism and are strong candidates for certain psychiatric and neurological disorders. Catecholamines 129-142 dopamine beta-hydroxylase Homo sapiens 109-112 17641409-5 2007 As beta(3)-adrenoceptors are activated at higher concentrations of catecholamines than beta(1) and beta(2)-adrenoceptors, they could play the roll of a receptor reserve. Catecholamines 67-81 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 3-10 17319503-7 2007 There are an increasing number of reports that indicate that vasopressin is effective for distributive shock, especially catecholamine-resistant septic shock. Catecholamines 121-134 arginine vasopressin Homo sapiens 61-72 18078508-1 2007 INTRODUCTION: Vasopressin has been shown to increase blood pressure in catecholamine-resistant septic shock. Catecholamines 71-84 vasopressin Sus scrofa 14-25 17075692-1 2007 alpha(1A)-adrenergic receptor (alpha(1A)-AR) regulates the cardiac and peripheral vascular system through sympathetic activation, and alpha(2A)-AR and alpha(2C)-AR subtypes are essential for presynaptic feedback regulation of catecholamine release from the central and peripheral sympathetic nerve. Catecholamines 226-239 calcium voltage-gated channel subunit alpha1 A Homo sapiens 0-8 17705792-6 2007 AMPK is localized close to the plasma membrane and its activation can inhibit both large conductance, calcium-activated potassium (BK) and background, TASK-like potassium channels, inducing membrane depolarization, voltage-gated calcium entry and neurosecretion of a range of transmitter and modulator substances, including catecholamines, ATP and acetylcholine. Catecholamines 324-338 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 17099901-3 2007 We herein describe sex and species differences in immunoreactivity for tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine synthesis, in the BST and MeA. Catecholamines 127-140 tyrosine 3-monooxygenase Microtus ochrogaster 71-91 17099901-3 2007 We herein describe sex and species differences in immunoreactivity for tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine synthesis, in the BST and MeA. Catecholamines 127-140 tyrosine 3-monooxygenase Microtus ochrogaster 93-95 17016691-3 2007 The usf1s1 C > T and usf1s2 G > A single-nucleotide polymorphisms (SNPs) in USF1 are associated with increased in vitro catecholamine-induced lipolysis in adipocytes. Catecholamines 126-139 upstream transcription factor 1 Homo sapiens 82-86 17713356-2 2007 In this study, we aimed to determine whether receptor antagonists for corticosterone or catecholamines would increase the LPS-induced tumor necrosis factor-alpha (TNF-alpha) response after exhaustive exercise. Catecholamines 88-102 tumor necrosis factor Rattus norvegicus 163-172 17982884-8 2007 We also found that the activities and/or the levels of the mRNA and protein of aromatic L-amino acid decarboxylase (AADC, DOPA decarboxylase), DBH, phenylethanolamine N-methyltransferase (PNMT), which synthesize dopamine, noradrenaline, and adrenaline, respectively, were also decreased in PD brains, indicating that all catecholamine systems were widely impaired in PD brains. Catecholamines 321-334 phenylethanolamine N-methyltransferase Homo sapiens 148-186 17313149-1 2007 A selective and sensitive method was developed for separation and simultaneous determination of catecholamines and amino acids by MEKC with LIF. Catecholamines 96-110 LIF interleukin 6 family cytokine Homo sapiens 140-143 17385068-0 2007 Renalase, a catecholamine-metabolising enzyme? Catecholamines 12-25 renalase, FAD dependent amine oxidase Homo sapiens 0-8 17385068-4 2007 The catecholamine-metabolising activity of renalase in plasma contrasts with previous investigations where catecholamines were found to be stable in human plasma, provided autoxidation is prevented by an antioxidant. Catecholamines 4-17 renalase, FAD dependent amine oxidase Homo sapiens 43-51 17385068-5 2007 The claim of catecholamine-metabolising activity of renalase was based on the generation of H(2)O(2) during incubation of the enzyme with catecholamines. Catecholamines 13-26 renalase, FAD dependent amine oxidase Homo sapiens 52-60 17385068-5 2007 The claim of catecholamine-metabolising activity of renalase was based on the generation of H(2)O(2) during incubation of the enzyme with catecholamines. Catecholamines 138-152 renalase, FAD dependent amine oxidase Homo sapiens 52-60 17385068-6 2007 Careful inspection and calculations of the data lead to the conclusion that the rate of H(2)O(2) generation is far too low to be ascribed to enzymatic conversion of catecholamines by renalase. Catecholamines 165-179 renalase, FAD dependent amine oxidase Homo sapiens 183-191 17356185-2 2007 Arginine vasopressin (AVP) has been shown to stabilize advanced shock states while facilitating reduction of catecholamine doses, but its use has never been reported in SAH. Catecholamines 109-122 arginine vasopressin Homo sapiens 0-20 17356185-2 2007 Arginine vasopressin (AVP) has been shown to stabilize advanced shock states while facilitating reduction of catecholamine doses, but its use has never been reported in SAH. Catecholamines 109-122 arginine vasopressin Homo sapiens 22-25 17713356-11 2007 These results indicate that exercise-induced catecholamines, acting through beta-ARs (especially the beta(1)-AR), are responsible for the exercise-induced suppression of plasma TNF-alpha after LPS administration. Catecholamines 45-59 tumor necrosis factor Rattus norvegicus 177-186 17622774-0 2007 Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats. Catecholamines 31-44 adrenoceptor beta 3 Rattus norvegicus 8-27 17622774-12 2007 These results show that functional beta-adrenoceptor subtype involved in catecholamine-mediated relaxations is beta(3)-adrenoceptor, and its function and mRNA expression are decreased in diabetes. Catecholamines 73-86 adrenoceptor beta 3 Rattus norvegicus 111-131 17205121-2 2006 We examined whether the relationship between coffee intake and incidence of CHD events is dependent on the metabolism of circulating catecholamines, as determined by functional polymorphism of the catechol-O-methyltransferase (COMT) gene. Catecholamines 133-147 catechol-O-methyltransferase Homo sapiens 197-225 18265860-1 2007 BACKGROUND AND AIMS: Arginin vasopressin (AVP) is a potent vasoconstrictor which has been used in vasodilatory shock when therapy with catecholamines and fluids has failed. Catecholamines 135-149 arginine vasopressin Homo sapiens 21-40 18265860-1 2007 BACKGROUND AND AIMS: Arginin vasopressin (AVP) is a potent vasoconstrictor which has been used in vasodilatory shock when therapy with catecholamines and fluids has failed. Catecholamines 135-149 arginine vasopressin Homo sapiens 42-45 17092485-4 2006 Following 7 days growth in the presence of NGF, expression of betaIII tubulin and tyrosine hydroxylase and increased intracellular catecholamines was detectable in PC12 cells, features characteristic of functional dopaminergic neurons. Catecholamines 131-145 nerve growth factor Rattus norvegicus 43-46 25792770-0 2007 The catecholamine system in health and disease -Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes. Catecholamines 4-17 tyrosine hydroxylase Homo sapiens 60-84 25792770-0 2007 The catecholamine system in health and disease -Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes. Catecholamines 95-108 tyrosine hydroxylase Homo sapiens 60-84 17365979-5 2007 RESULTS: All catecholamines in high concentration inhibited the suppression of CD 62 l expression and CD 11 b upregulation following stimulation with FMLP. Catecholamines 13-27 selectin P Homo sapiens 79-84 17365979-5 2007 RESULTS: All catecholamines in high concentration inhibited the suppression of CD 62 l expression and CD 11 b upregulation following stimulation with FMLP. Catecholamines 13-27 integrin subunit alpha M Homo sapiens 102-109 17365979-5 2007 RESULTS: All catecholamines in high concentration inhibited the suppression of CD 62 l expression and CD 11 b upregulation following stimulation with FMLP. Catecholamines 13-27 formyl peptide receptor 1 Homo sapiens 150-154 17365979-7 2007 CONCLUSIONS: The effect of catecholamines on the expression of CD 62 l explains the increased expression of L-selection on PMN observed after trauma. Catecholamines 27-41 selectin P Homo sapiens 63-68 17205121-2 2006 We examined whether the relationship between coffee intake and incidence of CHD events is dependent on the metabolism of circulating catecholamines, as determined by functional polymorphism of the catechol-O-methyltransferase (COMT) gene. Catecholamines 133-147 catechol-O-methyltransferase Homo sapiens 227-231 17054915-1 2006 Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons. Catecholamines 117-130 tyrosine hydroxylase Homo sapiens 0-20 17032647-9 2006 Together these results illustrate the distinct and complementary roles for PKA and ERK in catecholamine-stimulated lipolysis. Catecholamines 90-103 mitogen-activated protein kinase 1 Mus musculus 83-86 17054915-1 2006 Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons. Catecholamines 117-130 tyrosine hydroxylase Homo sapiens 22-46 16835395-5 2006 Qualitatively similar but significantly attenuated responses to the catecholamines were observed in tissue from ANXA1-null mice, an effect that was not associated with changes in beta-adrenoceptor mRNA expression. Catecholamines 68-82 annexin A1 Mus musculus 112-117 16835395-10 2006 Collectively, these studies suggest that ANXA1 supports aspects of adipose tissue mass and alters the sensitivity of epididymal adipose tissue to catecholamines, glucocorticoids, and LPS, thereby modulating lipolysis and IL-6 release. Catecholamines 146-160 annexin A1 Mus musculus 41-46 16996694-2 2006 The chromaffin granule Cyt b561 (CGCytb) is believed to transport electrons donated by extravesicular ascorbate (ASC) across the membrane to intravesicular monodehydroascorbate (MDA) supporting catecholamine synthesis in neuroendocrine tissues. Catecholamines 194-207 mitochondrially encoded cytochrome b Homo sapiens 23-28 17108165-0 2006 Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. Catecholamines 68-81 synuclein alpha Rattus norvegicus 0-15 17123948-0 2006 Role of exogenous arginine vasopressin in the management of catecholamine-refractory septic shock. Catecholamines 60-73 arginine vasopressin Homo sapiens 27-38 17356229-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Catecholamines 67-80 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 17356229-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Catecholamines 67-80 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 17117086-2 2006 MIBG scintigraphy and PET scanning with tracers of the sympathetic nervous system are based on uptake of catecholamines and catecholamine-like compounds by hNET, the human norepinephrine transporter. Catecholamines 105-119 solute carrier family 6 member 2 Homo sapiens 156-160 17117086-2 2006 MIBG scintigraphy and PET scanning with tracers of the sympathetic nervous system are based on uptake of catecholamines and catecholamine-like compounds by hNET, the human norepinephrine transporter. Catecholamines 105-119 solute carrier family 6 member 2 Homo sapiens 172-198 17117086-2 2006 MIBG scintigraphy and PET scanning with tracers of the sympathetic nervous system are based on uptake of catecholamines and catecholamine-like compounds by hNET, the human norepinephrine transporter. Catecholamines 105-118 solute carrier family 6 member 2 Homo sapiens 156-160 17117086-2 2006 MIBG scintigraphy and PET scanning with tracers of the sympathetic nervous system are based on uptake of catecholamines and catecholamine-like compounds by hNET, the human norepinephrine transporter. Catecholamines 105-118 solute carrier family 6 member 2 Homo sapiens 172-198 17143332-2 2006 In Pde3b-KO adipocytes we found decreased adipocyte size, unchanged insulin-stimulated phosphorylation of protein kinase B and activation of glucose uptake, enhanced catecholamine-stimulated lipolysis and insulin-stimulated lipogenesis, and blocked insulin inhibition of catecholamine-stimulated lipolysis. Catecholamines 166-179 phosphodiesterase 3B, cGMP-inhibited Mus musculus 3-8 17143332-2 2006 In Pde3b-KO adipocytes we found decreased adipocyte size, unchanged insulin-stimulated phosphorylation of protein kinase B and activation of glucose uptake, enhanced catecholamine-stimulated lipolysis and insulin-stimulated lipogenesis, and blocked insulin inhibition of catecholamine-stimulated lipolysis. Catecholamines 271-284 phosphodiesterase 3B, cGMP-inhibited Mus musculus 3-8 17076765-4 2006 Although the mechanism of the stress-mediated vasopressin release is not entirely understood, it is generally accepted that catecholamines play a crucial role in influencing water balance by modulating the secretion of vasopressin. Catecholamines 124-138 arginine vasopressin Homo sapiens 219-230 16979829-2 2006 Stimuli that activate the LC have been reported to increase expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 74-94 16979829-2 2006 Stimuli that activate the LC have been reported to increase expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 96-98 17175506-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr). Catecholamines 73-86 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 17175506-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr). Catecholamines 73-86 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 16996546-6 2006 Additional findings suggest that specific ERK-phosphorylation sites on ion channels and enzymes involved in catecholamine synthesis of NTS neurons may be involved in ERK-mediated satiation and meal termination. Catecholamines 108-121 mitogen-activated protein kinase 1 Homo sapiens 42-45 16996546-6 2006 Additional findings suggest that specific ERK-phosphorylation sites on ion channels and enzymes involved in catecholamine synthesis of NTS neurons may be involved in ERK-mediated satiation and meal termination. Catecholamines 108-121 mitogen-activated protein kinase 1 Homo sapiens 166-169 17108165-2 2006 We explored how alpha-syn overexpression in PC12 and chromaffin cells, which exhibit low endogenous alpha-syn levels relative to neurons, affects catecholamine release. Catecholamines 146-159 synuclein alpha Rattus norvegicus 16-25 17108165-3 2006 Overexpression of wild-type or A30P mutant alpha-syn in PC12 cell lines inhibited evoked catecholamine release without altering calcium threshold or cooperativity of release. Catecholamines 89-102 synuclein alpha Rattus norvegicus 43-52 17148734-2 2006 These stimuli, acting both on the central control stations of the stress system and its final effectors, catecholamines and glucocorticoids, and on the peripheral target tissues, can modulate insulin action in the body. Catecholamines 105-119 insulin Homo sapiens 192-199 17151983-4 2006 In such advanced, catecholamine-resistant shock states, arginine-vasopressin (AVP) has repeatedly caused an increase in mean arterial blood pressure, a decrease in toxic norepinephrine-dosages, as well as further beneficial hemodynamic, endocrinologic and renal effects. Catecholamines 18-31 arginine vasopressin Homo sapiens 65-76 16912137-0 2006 High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing. Catecholamines 69-82 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 18-22 17026486-0 2006 Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Catecholamines 0-13 chromogranin A Homo sapiens 75-89 17026486-5 2006 CHGA measurements yield insight into the pathogenesis of such human diseases as essential hypertension, in which deficiency of the catecholamine release-inhibitory CHGA fragment catestatin may trigger sympathoadrenal overactivity as an aetiologic culprit in the syndrome. Catecholamines 131-144 chromogranin A Homo sapiens 0-4 17026486-5 2006 CHGA measurements yield insight into the pathogenesis of such human diseases as essential hypertension, in which deficiency of the catecholamine release-inhibitory CHGA fragment catestatin may trigger sympathoadrenal overactivity as an aetiologic culprit in the syndrome. Catecholamines 131-144 chromogranin A Homo sapiens 164-168 17026486-5 2006 CHGA measurements yield insight into the pathogenesis of such human diseases as essential hypertension, in which deficiency of the catecholamine release-inhibitory CHGA fragment catestatin may trigger sympathoadrenal overactivity as an aetiologic culprit in the syndrome. Catecholamines 131-144 chromogranin A Homo sapiens 178-188 17035503-6 2006 The prolonged hypoglycemic effect of IL-1 is insulin-independent and develops against increased levels of glucocorticoids, catecholamines, and glucagon. Catecholamines 123-137 interleukin 1 complex Mus musculus 37-41 16778797-6 2006 Our results identified indeed a functioning GFRP/GTPCHI axis in epidermal keratinocytes and melanocytes in the cytosol, adding the missing link for 6BH4 de novo synthesis which in turn controls cofactor supply for catecholamine and serotonin biosynthesis as well as melanogenesis in the human epidermis. Catecholamines 214-227 GTP cyclohydrolase I feedback regulator Homo sapiens 44-48 16978782-0 2006 Role of PKA and PKC in histamine H1 receptor-mediated activation of catecholamine neurotransmitter synthesis. Catecholamines 68-81 histamine receptor H1 Homo sapiens 23-44 16978782-1 2006 Activation of the histamine H1 receptor stimulates tyrosine hydroxylase (TH) to increase catecholamine neurotransmitter synthesis in mammalian brain and adrenal tissues. Catecholamines 89-102 histamine receptor H1 Homo sapiens 18-39 17008600-8 2006 Cardiac-specific GRK2 knockout mice exhibited enhanced inotropic sensitivity to the beta-adrenergic receptor agonist isoproterenol, with impairment of normal inotropic and lusitropic tachyphylaxis, and exhibited accelerated development of catecholamine toxicity with chronic isoproterenol treatment. Catecholamines 239-252 G protein-coupled receptor kinase 2 Mus musculus 17-21 17008600-10 2006 In the adult heart, cardiac GRK2 is a major factor regulating inotropic and lusitropic tachyphylaxis to beta-adrenergic agonist, which likely contributes to its protective effects in catecholamine cardiomyopathy. Catecholamines 183-196 G protein-coupled receptor kinase 2 Mus musculus 28-32 16982509-0 2006 Vasopressin in catecholamine-resistant septic and cardiogenic shock in very-low-birthweight infants. Catecholamines 15-28 arginine vasopressin Homo sapiens 0-11 16982509-1 2006 AIM: To evaluate vasopressin as a rescue therapy in catecholamine-refractory septic and cardiogenic shock in very-low-birthweight (VLBW) infants. Catecholamines 52-65 arginine vasopressin Homo sapiens 17-28 16982509-2 2006 METHODS: Prospective assessment of vasopressin therapy in three VLBW infants with catecholamine-refractory septic shock (24 + 6 wk, 600 g) and cardiogenic shock (26 + 1 wk, 890 g; 26 + 1 wk, 880 g) at a university hospital. Catecholamines 82-95 arginine vasopressin Homo sapiens 35-46 16982509-4 2006 CONCLUSION: Although vasopressin appears to be a suitable rescue therapy in catecholamine-resistant septic shock in VLBW infants, further evaluation in controlled clinical trials is warranted. Catecholamines 76-89 arginine vasopressin Homo sapiens 21-32 16809443-6 2006 Circulating catecholamines were also increased by urocortin 3, providing additional evidence for sympathoadrenomedullary stimulation. Catecholamines 12-26 urocortin 3 Rattus norvegicus 50-61 17085797-10 2006 Paradoxically, downregulation of receptors with exogenous beta2-agonist drugs may occur more readily in cells that are relatively resistant to downregulation with exposure to endogenous catecholamine. Catecholamines 186-199 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 58-63 17060063-2 2006 The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation. Catecholamines 143-157 solute carrier family 22 member 2 Homo sapiens 4-32 17060063-2 2006 The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation. Catecholamines 143-157 solute carrier family 22 member 2 Homo sapiens 34-38 17060063-2 2006 The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation. Catecholamines 143-157 solute carrier family 22 member 2 Homo sapiens 40-47 16824046-0 2006 Dual role of calbindin-D28K in vesicular catecholamine release from mouse chromaffin cells. Catecholamines 41-54 calbindin 1 Mus musculus 13-17 16824046-3 2006 Amperometric recordings of catecholamine exocytosis from wild-type and calbindin-D(28K) knockout mouse chromaffin cells reveal a strong reduction in the number of released vesicles, as well as in the amount of neurotransmitter released per fusion event in knockout cells. Catecholamines 27-40 calbindin 1 Mus musculus 71-86 16824046-6 2006 Consequently, the possibility that calbindin-D(28K) functions not only as a Ca(2+) buffer but also as a modulator of vesicular catecholamine release is discussed. Catecholamines 127-140 calbindin 1 Mus musculus 35-50 16923751-8 2006 Interestingly, focal transduction of Ad-CGI-HCN1-DeltaDeltaDelta in the left atrium of animals with sick-sinus syndrome reproducibly induced a stable, catecholamine-responsive in vivo "bioartificial node" that exhibited a physiological heart rate and was capable of reliably pacing the myocardium, substantially reducing electronic pacing. Catecholamines 151-164 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Cavia porcellus 44-48 16957086-7 2006 Although multiple molecular mechanisms may be responsible for the perturbation of cytosolic catecholamine homeostasis, this study provides critical evidence about how alpha-synuclein might exert its cytotoxicity and selectively damage catecholaminergic cells. Catecholamines 92-105 synuclein alpha Rattus norvegicus 167-182 16470514-1 2006 The enzyme catechol-O-methyltransferase (COMT) plays an important role in the metabolism of catechol estrogens and degradation of the catecholamine neurotransmitters, such as epinephrine. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 11-39 16925984-7 2006 Co-localization studies in the mNTS demonstrated the presence of IRS-2 in catecholamine neurons. Catecholamines 74-87 insulin receptor substrate 2 Rattus norvegicus 65-70 16931995-4 2006 Infusion of vasopressin (0.01-0.04 U/min) decreases catecholamine requirements in patients with sepsis and other types of vasodilatory shock. Catecholamines 52-65 arginine vasopressin Homo sapiens 12-23 16957086-0 2006 Alpha-synuclein overexpression increases cytosolic catecholamine concentration. Catecholamines 51-64 synuclein alpha Rattus norvegicus 0-15 16957086-3 2006 Chromaffin cells isolated from transgenic mice that overexpress A30P alpha-synuclein displayed significantly increased cytosolic catecholamine levels as measured by intracellular patch electrochemistry, whereas cells overexpressing the WT protein and those from knock-out animals were not different from controls. Catecholamines 129-142 synuclein, alpha Mus musculus 69-84 16470514-1 2006 The enzyme catechol-O-methyltransferase (COMT) plays an important role in the metabolism of catechol estrogens and degradation of the catecholamine neurotransmitters, such as epinephrine. Catecholamines 134-147 catechol-O-methyltransferase Homo sapiens 41-45 24353453-7 2006 PTH regulation is also influenced by the initial bone mineral content, age, gender, training state, and other hormonal and metabolic factors (catecholamines, lactic acid and calcium concentrations). Catecholamines 142-156 parathyroid hormone Homo sapiens 0-3 16932808-6 2006 Exposure to catecholamines in Casq2-null myocytes caused increased diastolic SR Ca2+ leak, resulting in premature spontaneous SR Ca2+ releases and triggered beats. Catecholamines 12-26 calsequestrin 2 Mus musculus 30-35 16643958-0 2006 Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta. Catecholamines 37-50 midkine Mus musculus 0-7 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 33-36 catechol-O-methyltransferase Homo sapiens 279-308 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 33-36 catechol-O-methyltransferase Homo sapiens 310-314 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 279-308 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 310-314 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 279-308 16906330-5 2006 A classical metabolic pathway of CAs shared by the nervous and endocrine systems is present in the immune cells, i.e., the immunocytes have the enzymes for synthesis of CAs [e.g. tyrosine hydroxylase (TH)] and the enzymes for degradation of CAs [e.g. monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT)]. Catecholamines 169-172 catechol-O-methyltransferase Homo sapiens 310-314 16822482-8 2006 Collectively, these results suggest that enhanced expression of NQO1, GST, and SULT1A1 may contribute to the antioxidant effects of E(2) in the striatum, an area of the brain that may be particularly prone to oxidative stress because of its high content of catecholamines. Catecholamines 257-271 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 64-68 16480771-2 2006 It is classically admitted that beta-adrenoceptors (beta-AR) of the beta1 and beta2 subtypes mediate the effects of catecholamines on the force of contraction of cardiac muscle, and on the relaxation of vascular smooth muscle. Catecholamines 116-130 adrenoceptor beta 3 Homo sapiens 52-59 16480771-2 2006 It is classically admitted that beta-adrenoceptors (beta-AR) of the beta1 and beta2 subtypes mediate the effects of catecholamines on the force of contraction of cardiac muscle, and on the relaxation of vascular smooth muscle. Catecholamines 116-130 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 68-73 16480771-2 2006 It is classically admitted that beta-adrenoceptors (beta-AR) of the beta1 and beta2 subtypes mediate the effects of catecholamines on the force of contraction of cardiac muscle, and on the relaxation of vascular smooth muscle. Catecholamines 116-130 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 78-83 16643958-6 2006 The remarkable increases in levels of expression of tyrosine hydroxylase, DOPA decarboxylase and dopamine beta-hydroxylase suggest that MK together with PTN are very important regulators of the catecholamine pathway in mouse aorta and may critically regulate catecholamine biosynthesis and function in inflammatory and the other pathological conditions in which Mk or Ptn are upregulated. Catecholamines 194-207 pleiotrophin Mus musculus 153-156 18079991-11 2006 The reported effects of IFN"s on brain catecholamines and serotonin have been very varied. Catecholamines 39-53 interferon alpha 1 Homo sapiens 24-28 16873551-8 2006 Our results suggest that the R176Q mutation in RyR2 predisposes the heart to catecholamine-induced oscillatory calcium-release events that trigger a calcium-dependent ventricular arrhythmia. Catecholamines 77-90 ryanodine receptor 2, cardiac Mus musculus 47-51 16467400-0 2006 Stable gene silencing of synaptotagmin I in rat PC12 cells inhibits Ca2+-evoked release of catecholamine. Catecholamines 91-104 synaptotagmin 1 Rattus norvegicus 25-40 16467400-9 2006 The reduction of stimulated catecholamine release in the syt I knockdown cells strongly suggests that although syt I is clearly involved in catecholamine release, it is not the only protein to regulate stimulated release in PC12 cells, and another protein likely has a role as a Ca2+ sensor for regulated release of transmitter. Catecholamines 28-41 synaptotagmin 1 Rattus norvegicus 57-62 16467400-9 2006 The reduction of stimulated catecholamine release in the syt I knockdown cells strongly suggests that although syt I is clearly involved in catecholamine release, it is not the only protein to regulate stimulated release in PC12 cells, and another protein likely has a role as a Ca2+ sensor for regulated release of transmitter. Catecholamines 140-153 synaptotagmin 1 Rattus norvegicus 111-116 16738005-1 2006 Focus on "stable gene silencing of synaptotagmin I in rat PC12 cells inhibits Ca2+-evoked release of catecholamine". Catecholamines 101-114 synaptotagmin 1 Rattus norvegicus 35-50 16895541-2 2006 Activation of angiotensin II AT1 receptors (AT1R) stimulates catecholamine systems within both central and peripheral tissues that are associated with blood pressure control. Catecholamines 61-74 angiotensin II receptor, type 1a Rattus norvegicus 44-48 16798884-0 2006 Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Catecholamines 90-103 neuropeptide Y Mus musculus 16-30 17131588-5 2006 DBH encodes the enzyme that converts dopamine to noradrenaline and is crucial to catecholamine regulation. Catecholamines 81-94 dopamine beta-hydroxylase Homo sapiens 0-3 16764822-1 2006 Tyrosine hydroxylase (TH), the biosynthetic enzyme of catecholamine, is synthesized specifically in catecholaminergic neurons. Catecholamines 54-67 tyrosine hydroxylase Homo sapiens 0-20 16764822-1 2006 Tyrosine hydroxylase (TH), the biosynthetic enzyme of catecholamine, is synthesized specifically in catecholaminergic neurons. Catecholamines 54-67 tyrosine hydroxylase Homo sapiens 22-24 16828089-0 2006 Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice. Catecholamines 61-74 forkhead box C2 Mus musculus 120-125 16828089-2 2006 This is due, in part, to enhanced catecholamine-induced cAMP-PKA signaling in FOXC2 transgenic mice. Catecholamines 34-47 forkhead box C2 Mus musculus 78-83 16848906-3 2006 RESULTS: Variations in the catecholamine metabolizing enzyme genes (MAOA and COMT) showed significant associations with the maximum post-operative pain rating while the serotonin transporter gene (SLC6A4) showed association with the onset time of post-operative pain. Catecholamines 27-40 monoamine oxidase A Homo sapiens 68-72 16848906-3 2006 RESULTS: Variations in the catecholamine metabolizing enzyme genes (MAOA and COMT) showed significant associations with the maximum post-operative pain rating while the serotonin transporter gene (SLC6A4) showed association with the onset time of post-operative pain. Catecholamines 27-40 catechol-O-methyltransferase Homo sapiens 77-81 16786331-12 2006 CONCLUSION: In catecholamine-dependent septic shock patients managed with systematic glucocorticoid therapy the results of ACTH stimulation do not predict hemodynamic improvement. Catecholamines 15-28 proopiomelanocortin Homo sapiens 123-127 16375934-5 2006 It is suggested that the central inhibitory action of CCK antagonist on the cortisol and catecholamine release produced by visceral pain is due to the inhibition of peripheral CCK1 type receptors in the central centrifugal descending pain facilitatory system in sheep perhaps via the hypothalamic-pituitary-adrenal axis. Catecholamines 89-102 cholecystokinin Ovis aries 54-57 16870728-3 2006 Previous results from mouse mutant models and pharmacological/neurotoxin blockades have demonstrated a critical role for SNAP-25-containing SNARE complexes in action potential (AP)-dependent release at cholinergic and glutamatergic synapses and for calcium-triggered catecholamine release from chromaffin cells. Catecholamines 267-280 synaptosomal-associated protein 25 Mus musculus 121-128 16870728-3 2006 Previous results from mouse mutant models and pharmacological/neurotoxin blockades have demonstrated a critical role for SNAP-25-containing SNARE complexes in action potential (AP)-dependent release at cholinergic and glutamatergic synapses and for calcium-triggered catecholamine release from chromaffin cells. Catecholamines 267-280 vesicle transport through interaction with t-SNAREs 1B Mus musculus 140-145 16476412-2 2006 We begin by considering the COMT gene, its transcripts and proteins, and its relevance for central catecholamine function. Catecholamines 99-112 catechol-O-methyltransferase Homo sapiens 28-32 16798884-0 2006 Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Catecholamines 90-103 neuropeptide Y Mus musculus 32-35 16798884-0 2006 Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Catecholamines 90-103 neuropeptide Y Mus musculus 83-86 16798884-2 2006 We found that in response to NPY, primary cultures of mouse adrenal chromaffin cells secreted catecholamine, and that this effect was abolished in cultures from NPY Y(1) receptor knockout mice (Y(1)-/-). Catecholamines 94-107 neuropeptide Y Mus musculus 29-32 16798884-8 2006 We propose that NPY controls the release and synthesis of catecholamine from the adrenal medulla and consequently contributes to the sympathoadrenal tone. Catecholamines 58-71 neuropeptide Y Mus musculus 16-19 16843057-1 2006 Annexin A7 (synexin, annexin VII) is postulated to promote membrane fusion during surfactant secretion in alveolar type II cells and catecholamine secretion in adrenal chromaffin cells. Catecholamines 133-146 annexin A7 Homo sapiens 0-10 16464910-0 2006 Attenuated stress-induced catecholamine release in mice lacking the vasopressin V1b receptor. Catecholamines 26-39 arginine vasopressin receptor 1B Mus musculus 68-92 16843057-1 2006 Annexin A7 (synexin, annexin VII) is postulated to promote membrane fusion during surfactant secretion in alveolar type II cells and catecholamine secretion in adrenal chromaffin cells. Catecholamines 133-146 annexin A7 Homo sapiens 12-19 16843057-1 2006 Annexin A7 (synexin, annexin VII) is postulated to promote membrane fusion during surfactant secretion in alveolar type II cells and catecholamine secretion in adrenal chromaffin cells. Catecholamines 133-146 annexin A7 Homo sapiens 21-32 16691439-15 2006 The transient nature of the phosphorylation of CREB may be responsible for the short-lived induction of transcription of catecholamine biosynthetic enzymes after brief exposure to a single immobilization stress. Catecholamines 121-134 cAMP responsive element binding protein 1 Rattus norvegicus 47-51 16805833-2 2006 In this study, we investigated whether the retinoic acid receptor (RAR), a transcription factor specifically activated by all-trans-RA, could directly regulate transcription of tyrosine hydroxylase (TH), the first and rate-limiting step in the catecholamine biosynthesis pathway. Catecholamines 244-257 retinoic acid receptor alpha Homo sapiens 43-65 16741673-17 2006 The presence of these additional populations of TH-positive neurons in the adult primate CNS has implications for functional catecholamine neurotransmission, its derangement in disease and drug abuse, and its rescue by gene therapeutic maneuvers in neurodegenerative diseases such as Parkinson"s disease. Catecholamines 125-138 tyrosine hydroxylase Homo sapiens 48-50 16614076-0 2006 Differential responsiveness of dopamine-beta-hydroxylase gene expression to glucoprivation in different catecholamine cell groups. Catecholamines 104-117 dopamine beta-hydroxylase Homo sapiens 31-56 16614076-3 2006 Here we used in situ hybridization and immunohistochemistry to investigate effects of glucoprivation on expression of the gene for the catecholamine biosynthetic enzyme, dopamine-beta-hydroxylase (DBH), to further localize the critical cell populations. Catecholamines 135-148 dopamine beta-hydroxylase Homo sapiens 170-195 16614076-3 2006 Here we used in situ hybridization and immunohistochemistry to investigate effects of glucoprivation on expression of the gene for the catecholamine biosynthetic enzyme, dopamine-beta-hydroxylase (DBH), to further localize the critical cell populations. Catecholamines 135-148 dopamine beta-hydroxylase Homo sapiens 197-200 16614076-7 2006 Previous microinjection of the retrogradely transported catecholamine immunotoxin (anti-DBH-saporin, or DSAP) into the paraventricular nucleus of the hypothalamus reduced the number of DBH-immunoreactive cells in cell groups known to project to the paraventricular nucleus of the hypothalamus as well as reducing the 2DG-stimulated increases in total DBH mRNA expression in the caudal ventrolateral medulla and A2. Catecholamines 56-69 dopamine beta-hydroxylase Homo sapiens 88-91 16614076-7 2006 Previous microinjection of the retrogradely transported catecholamine immunotoxin (anti-DBH-saporin, or DSAP) into the paraventricular nucleus of the hypothalamus reduced the number of DBH-immunoreactive cells in cell groups known to project to the paraventricular nucleus of the hypothalamus as well as reducing the 2DG-stimulated increases in total DBH mRNA expression in the caudal ventrolateral medulla and A2. Catecholamines 56-69 dopamine beta-hydroxylase Homo sapiens 185-188 16614076-7 2006 Previous microinjection of the retrogradely transported catecholamine immunotoxin (anti-DBH-saporin, or DSAP) into the paraventricular nucleus of the hypothalamus reduced the number of DBH-immunoreactive cells in cell groups known to project to the paraventricular nucleus of the hypothalamus as well as reducing the 2DG-stimulated increases in total DBH mRNA expression in the caudal ventrolateral medulla and A2. Catecholamines 56-69 dopamine beta-hydroxylase Homo sapiens 185-188 16611835-0 2006 Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. Catecholamines 56-70 hypocretin Mus musculus 0-6 16645894-8 2006 Epinephrine is regulated in part through its biosynthesis catalyzed by the final enzyme in the catecholamine pathway, phenylethanolamine N-methyltransferase (E.C. Catecholamines 95-108 phenylethanolamine N-methyltransferase Homo sapiens 118-156 16805827-3 2006 Stimulation of catecholamine secretion and enhanced neuropeptide biosynthesis are effects exerted by PACAP at the adrenomedullary synapse in vivo and on PC12 cells in vitro through stimulation of the specific PAC1 receptor. Catecholamines 15-28 adenylate cyclase activating polypeptide 1 Rattus norvegicus 101-106 16611835-11 2006 The evidence presented here revealed that orexin neurons are regulated by catecholamines in a complex manner. Catecholamines 74-88 hypocretin Mus musculus 42-48 16805833-2 2006 In this study, we investigated whether the retinoic acid receptor (RAR), a transcription factor specifically activated by all-trans-RA, could directly regulate transcription of tyrosine hydroxylase (TH), the first and rate-limiting step in the catecholamine biosynthesis pathway. Catecholamines 244-257 retinoic acid receptor alpha Homo sapiens 67-70 16805833-2 2006 In this study, we investigated whether the retinoic acid receptor (RAR), a transcription factor specifically activated by all-trans-RA, could directly regulate transcription of tyrosine hydroxylase (TH), the first and rate-limiting step in the catecholamine biosynthesis pathway. Catecholamines 244-257 tyrosine hydroxylase Homo sapiens 177-197 16805833-2 2006 In this study, we investigated whether the retinoic acid receptor (RAR), a transcription factor specifically activated by all-trans-RA, could directly regulate transcription of tyrosine hydroxylase (TH), the first and rate-limiting step in the catecholamine biosynthesis pathway. Catecholamines 244-257 tyrosine hydroxylase Homo sapiens 199-201 16644734-1 2006 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. Catecholamines 81-95 tyrosine hydroxylase Homo sapiens 0-20 16644734-1 2006 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. Catecholamines 81-95 tyrosine hydroxylase Homo sapiens 22-24 16510159-2 2006 This study was designed to assess whether catecholamines and in particular adrenergic receptor-dependent pathways, modulate benzo(alpha)pyrene (B(alpha)P)-induced hepatic CYP1A2. Catecholamines 42-56 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 171-177 16794074-1 2006 During fasting, increased concentrations of circulating catecholamines promote the mobilization of lipid stores from adipose tissue in part by phosphorylating and inactivating acetyl-coenzyme A carboxylase (ACC), the rate-limiting enzyme in fatty acid synthesis. Catecholamines 56-70 anterior capsular cataract Mus musculus 176-205 16794074-1 2006 During fasting, increased concentrations of circulating catecholamines promote the mobilization of lipid stores from adipose tissue in part by phosphorylating and inactivating acetyl-coenzyme A carboxylase (ACC), the rate-limiting enzyme in fatty acid synthesis. Catecholamines 56-70 anterior capsular cataract Mus musculus 207-210 16510159-5 2006 The results suggest that alterations in central catecholamines modulate 7-methoxyresorufin O-demethylase activity (MROD), CYP1A2 mRNA and protein levels in the B(alpha)P-induced state. Catecholamines 48-62 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 122-128 16510159-6 2006 In particular, central catecholamine depletion, dexmedetomidine-induced inhibition of noradrenaline release and blockade of alpha(1)-adrenoceptors with prazosin, up-regulated CYP1A2 expression. Catecholamines 23-36 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 175-181 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 57-71 tumor necrosis factor Homo sapiens 134-143 16595669-1 2006 Hormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-stimulated lipolysis in adipocytes. Catecholamines 69-82 lipase, hormone sensitive Mus musculus 0-24 16595669-1 2006 Hormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-stimulated lipolysis in adipocytes. Catecholamines 69-82 lipase, hormone sensitive Mus musculus 26-29 16595669-2 2006 HSL-dependent lipolysis in response to catecholamines is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an essential lipid droplet (LD)-associated protein. Catecholamines 39-53 lipase, hormone sensitive Mus musculus 0-3 16595669-2 2006 HSL-dependent lipolysis in response to catecholamines is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an essential lipid droplet (LD)-associated protein. Catecholamines 39-53 perilipin 1 Mus musculus 121-132 16595669-2 2006 HSL-dependent lipolysis in response to catecholamines is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an essential lipid droplet (LD)-associated protein. Catecholamines 39-53 perilipin 1 Mus musculus 134-140 16595669-2 2006 HSL-dependent lipolysis in response to catecholamines is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an essential lipid droplet (LD)-associated protein. Catecholamines 39-53 perilipin 1 Mus musculus 156-193 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 57-71 interleukin 10 Homo sapiens 175-180 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 57-71 interleukin 4 Homo sapiens 182-186 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 57-71 transforming growth factor beta 1 Homo sapiens 192-200 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 73-76 tumor necrosis factor Homo sapiens 134-143 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 73-76 interleukin 10 Homo sapiens 175-180 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 73-76 interleukin 4 Homo sapiens 182-186 16855135-2 2006 Recent evidence indicates that glucocorticoids (GCs) and catecholamines (CAs), the major stress hormones, inhibit systemically IL-12, TNF-alpha, and INF-gamma, but upregulate IL-10, IL-4, and TGF-beta production. Catecholamines 73-76 transforming growth factor beta 1 Homo sapiens 192-200 16603190-12 2006 CONCLUSIONS: These data suggest that Raf-1/MEK/ERK1/2 pathway activation may be a novel strategy to treat pheochromocytoma and other catecholamine-producing tumors. Catecholamines 133-146 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 37-42 16542735-0 2006 Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report. Catecholamines 104-117 catechol-O-methyltransferase Homo sapiens 17-45 17957479-0 2006 Synapsin II negatively regulates catecholamine release. Catecholamines 33-46 synapsin II Mus musculus 0-11 16810071-0 2006 Neuropeptide Y induced attenuation of catecholamine synthesis in the rat mesenteric arterial bed. Catecholamines 38-51 neuropeptide Y Rattus norvegicus 0-14 16603190-12 2006 CONCLUSIONS: These data suggest that Raf-1/MEK/ERK1/2 pathway activation may be a novel strategy to treat pheochromocytoma and other catecholamine-producing tumors. Catecholamines 133-146 mitogen-activated protein kinase kinase 7 Homo sapiens 43-46 16603190-12 2006 CONCLUSIONS: These data suggest that Raf-1/MEK/ERK1/2 pathway activation may be a novel strategy to treat pheochromocytoma and other catecholamine-producing tumors. Catecholamines 133-146 mitogen-activated protein kinase 3 Homo sapiens 47-53 16755443-3 2006 Thus, we hypothesized that eNOS gene polymorphism could influence perioperative hemodynamics and catecholamine support in patients undergoing cardiac surgery with CPB. Catecholamines 97-110 nitric oxide synthase 3 Homo sapiens 27-31 16764338-7 2006 This is the first report of the effects of IFN-beta administration on intracellular catecholamines in MS patients. Catecholamines 84-98 interferon beta 1 Homo sapiens 43-51 16909734-4 2006 Infusion of vasopressin (VP) which is detectable at inappropriately low level in advanced phase of septic shock might allow withdrawal of catecholamines, as it maintains adequate mean arterial pressure (MAP), improves urine output and leaves perfusion of vital organs unhindered. Catecholamines 138-152 arginine vasopressin Homo sapiens 12-23 16630538-8 2006 These data establish the transcriptional regulation of adipocyte PRL by the superdistal PRL promoter, its transient expression during adipogenesis, and the stimulatory effect of catecholamines and PACAP. Catecholamines 178-192 prolactin Homo sapiens 65-68 16600401-7 2006 These results indicate that catecholamines may play an inhibitory role on the activation of the DVC neurons by CCK. Catecholamines 28-42 cholecystokinin Rattus norvegicus 111-114 16682353-3 2006 Catecholamines up (Catsup), which encodes a negative regulator of tyrosine hydroxylase , the rate-limiting step in the synthesis of the neurotransmitter dopamine, is a pleiotropic quantitative trait gene in Drosophila melanogaster. Catecholamines 0-14 Catecholamines up Drosophila melanogaster 19-25 16909734-4 2006 Infusion of vasopressin (VP) which is detectable at inappropriately low level in advanced phase of septic shock might allow withdrawal of catecholamines, as it maintains adequate mean arterial pressure (MAP), improves urine output and leaves perfusion of vital organs unhindered. Catecholamines 138-152 arginine vasopressin Homo sapiens 25-27 16415089-2 2006 Based on its pharmacology and reported enhancing effects on dopamine metabolism and tyrosine hydroxylase activity, we investigated whether it could modulate the activity of aromatic l-amino acid decarboxylase (AAAD), the second enzyme for the biosynthesis of catecholamines and indoleamines. Catecholamines 259-273 dopa decarboxylase Mus musculus 173-208 16612252-0 2006 The chromogranin A fragment catestatin: specificity, potency and mechanism to inhibit exocytotic secretion of multiple catecholamine storage vesicle co-transmitters. Catecholamines 119-132 chromogranin A Homo sapiens 4-18 16612252-0 2006 The chromogranin A fragment catestatin: specificity, potency and mechanism to inhibit exocytotic secretion of multiple catecholamine storage vesicle co-transmitters. Catecholamines 119-132 chromogranin A Homo sapiens 28-38 16612252-3 2006 Studies in our laboratory demonstrated that catestatin acts at the nicotinic acetylcholine receptor to inhibit catecholamine secretion. Catecholamines 111-124 chromogranin A Homo sapiens 44-54 16612252-5 2006 AIM: Here we probed the specificity of catestatin"s actions among its co-transmitters: catecholamines, ATP, and neuropeptide Y (NPY). Catecholamines 87-101 chromogranin A Homo sapiens 39-49 16612252-7 2006 RESULTS: We observed that, among chromaffin granule co-transmitters, only catestatin and NPY inhibited catecholamine release induced by nicotinic-cholinergic stimulation; catestatin was more than tenfold more potent than NPY in this setting. Catecholamines 103-116 chromogranin A Homo sapiens 74-84 16612252-7 2006 RESULTS: We observed that, among chromaffin granule co-transmitters, only catestatin and NPY inhibited catecholamine release induced by nicotinic-cholinergic stimulation; catestatin was more than tenfold more potent than NPY in this setting. Catecholamines 103-116 neuropeptide Y Homo sapiens 89-92 16612252-10 2006 Catestatin inhibited nicotinic-cholinergic co-release of all classes of chromaffin granule co-transmitters: catecholamines, chromogranins, neuropeptides, and ATP. Catecholamines 108-122 chromogranin A Homo sapiens 0-10 16612252-11 2006 Naturally occurring variants of human catestatin (Gly364Ser and Pro370Leu) exhibited parallel changes in potency to inhibit secretion of catecholamines and ATP. Catecholamines 137-151 chromogranin A Homo sapiens 38-48 16573647-0 2006 Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. Catecholamines 76-90 solute carrier family 6 member 2 Homo sapiens 34-60 16573647-2 2006 Depolarization of sympathetic neurons stimulates catecholamine synthesis, and several studies suggest that NET can be regulated by catecholamines. Catecholamines 131-145 solute carrier family 6 member 2 Homo sapiens 107-110 16573647-4 2006 To determine if induction of NET mRNA was a result of increased catecholamines, we used pharmacological manipulations to (i) inhibit tyrosine hydroxylase activity in neurons depolarized with 30 mm KCl, thereby preventing increased catecholamines, or (ii) stimulate tyrosine hydroxylase activity in the absence of depolarization. Catecholamines 64-78 solute carrier family 6 member 2 Homo sapiens 29-32 16573647-5 2006 Inhibiting the depolarization-induced increase in catecholamines prevented the up-regulation of NET mRNA, but did not block the increase in tyrosine hydroxylase (TH) mRNA. Catecholamines 50-64 solute carrier family 6 member 2 Homo sapiens 96-99 16573647-6 2006 Furthermore, stimulating catecholamine production in the absence of depolarization elevated NE uptake, NET protein, and NET mRNA in sympathetic neurons. Catecholamines 25-38 solute carrier family 6 member 2 Homo sapiens 103-106 16573647-6 2006 Furthermore, stimulating catecholamine production in the absence of depolarization elevated NE uptake, NET protein, and NET mRNA in sympathetic neurons. Catecholamines 25-38 solute carrier family 6 member 2 Homo sapiens 120-123 16573647-7 2006 Similarly, elevating endogenous catecholamines in SK-N-BE2M17 neuroblastoma cells increased NE uptake and NET expression. Catecholamines 32-46 solute carrier family 6 member 2 Homo sapiens 106-109 16573647-8 2006 These data suggest that chronic depolarization of sympathetic neurons induces NET expression through increasing catecholamines, and that M17 neuroblastoma cells provide a model system in which to investigate catechol regulation of NET expression. Catecholamines 112-126 solute carrier family 6 member 2 Homo sapiens 78-81 16415089-2 2006 Based on its pharmacology and reported enhancing effects on dopamine metabolism and tyrosine hydroxylase activity, we investigated whether it could modulate the activity of aromatic l-amino acid decarboxylase (AAAD), the second enzyme for the biosynthesis of catecholamines and indoleamines. Catecholamines 259-273 dopa decarboxylase Mus musculus 210-214 16266697-2 2006 In addition, CAs are known to be metabolized by catechol-O-methyltransferase (COMT) to produce their 3-O-methyl metabolites. Catecholamines 13-16 catechol-O-methyltransferase Homo sapiens 48-76 16406650-5 2006 COMT metabolizes catechols and catecholamines, a pathway relevant to neurodegeneration. Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 0-4 16575349-2 2006 Initial evaluations have shown that vasopressin may have a role in catecholamine refractory shock in adults. Catecholamines 67-80 arginine vasopressin Homo sapiens 36-47 16506193-2 2006 It has been shown that CAPS1 regulates catecholamine release from neuroendocrine cells, whereas CAPS2 is involved in the release of two neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), from parallel fibers of cerebellar granule cells. Catecholamines 39-52 Ca2+-dependent secretion activator Mus musculus 23-28 16527823-2 2006 Alternative mRNA splicing gives rise to perilipin A and B. Hormones such as catecholamines and insulin regulate triacylglycerol metabolism through reversible serine phosphorylation of perilipin A. Catecholamines 76-90 perilipin 1 Homo sapiens 40-49 16527823-2 2006 Alternative mRNA splicing gives rise to perilipin A and B. Hormones such as catecholamines and insulin regulate triacylglycerol metabolism through reversible serine phosphorylation of perilipin A. Catecholamines 76-90 perilipin 1 Homo sapiens 184-193 16527823-6 2006 This association was controlled by insulin and catecholamine: perilipin B was specifically depleted from the plasma membrane in response to the catecholamine isoproterenol, while insulin increased the amount of threonine phosphorylated perilipin at the plasma membrane. Catecholamines 47-60 perilipin 1 Homo sapiens 62-71 16527823-6 2006 This association was controlled by insulin and catecholamine: perilipin B was specifically depleted from the plasma membrane in response to the catecholamine isoproterenol, while insulin increased the amount of threonine phosphorylated perilipin at the plasma membrane. Catecholamines 47-60 insulin Homo sapiens 179-186 16527823-6 2006 This association was controlled by insulin and catecholamine: perilipin B was specifically depleted from the plasma membrane in response to the catecholamine isoproterenol, while insulin increased the amount of threonine phosphorylated perilipin at the plasma membrane. Catecholamines 47-60 perilipin 1 Homo sapiens 236-245 16556435-1 2006 Transient expression of tyrosine hydroxylase (TH, the first enzyme in catecholamine synthesis) has been shown in different brain and peripheral structures of various species. Catecholamines 70-83 tyrosine 3-monooxygenase Ovis aries 24-44 16556435-1 2006 Transient expression of tyrosine hydroxylase (TH, the first enzyme in catecholamine synthesis) has been shown in different brain and peripheral structures of various species. Catecholamines 70-83 tyrosine 3-monooxygenase Ovis aries 46-48 16564429-6 2006 The COMT G158A substitution results in a three- to four-fold decreased activity of the COMT enzyme, which may influence CNS synaptic catecholamine breakdown and could also play a role in MS inflammation. Catecholamines 133-146 catechol-O-methyltransferase Homo sapiens 4-8 16564429-6 2006 The COMT G158A substitution results in a three- to four-fold decreased activity of the COMT enzyme, which may influence CNS synaptic catecholamine breakdown and could also play a role in MS inflammation. Catecholamines 133-146 catechol-O-methyltransferase Homo sapiens 87-91 16266697-2 2006 In addition, CAs are known to be metabolized by catechol-O-methyltransferase (COMT) to produce their 3-O-methyl metabolites. Catecholamines 13-16 catechol-O-methyltransferase Homo sapiens 78-82 16672262-1 2006 Tyrosine hydroxylase (TH), an iron-containing enzyme, catalyzes the first and rate-limiting step of catecholamine biosynthesis, and requires tetrahydrobiopterin (BH4) as a cofactor. Catecholamines 100-113 tyrosine hydroxylase Homo sapiens 0-20 16510153-15 2006 Multiple signal transduction pathways between G-protein and beta(3)-AR may protect myocardium from catecholamine-induced cardiotoxic effects. Catecholamines 99-112 adrenergic receptor, beta 3 Mus musculus 60-70 16699302-1 2006 Familial catecholamine secreting tumors have been associated with multiple endocrine neoplasia type 2, Von Hippel-Lindau disease and neurofibromatosis type 1. Catecholamines 9-22 neurofibromin 1 Homo sapiens 133-157 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 tyrosine hydroxylase Homo sapiens 207-227 16675002-2 2006 These catecholamines can be modulated by the 5-HT(1A) serotonin receptor agonist 8-hydroxy-2-(N,N-di-n-propylamino)tetralin (8-OH DPAT). Catecholamines 6-20 5-hydroxytryptamine receptor 1A Rattus norvegicus 45-52 16315141-2 2006 PAMP is a peptide that has various physiological functions, including its role as a proangiogenic factor in facilitating tumor growth and its inhibitory effect on catecholamine secretion at nicotinic receptors. Catecholamines 163-176 adrenomedullin Homo sapiens 0-4 16487263-1 2006 alpha(1)-Adrenoceptors (AR) mediate growth factor-like activity of catecholamines on vascular smooth muscle cells (SMC) and adventitial fibroblasts. Catecholamines 67-81 myotrophin Rattus norvegicus 36-49 16505652-11 2006 In contrast, administration of exogenous catecholamines into the distal airspaces can stimulate alveolar fluid clearance in the human lung, an effect that is mediated in part by cystic fibrosis transmembrane conductance regulator. Catecholamines 41-55 CF transmembrane conductance regulator Homo sapiens 178-229 16505698-0 2006 Peripheral administration of vasopressin for catecholamine-resistant hypotension complicated by skin necrosis. Catecholamines 45-58 arginine vasopressin Homo sapiens 29-40 16509586-1 2006 We derived homology models for all human catecholamine-binding GPCRs (CABRs; the alpha-1, alpha-2, and beta-adrenoceptors and the D1-type and D2-type dopamine receptor) using the bovine rhodopsin-11-cis-retinal X-ray structure. Catecholamines 41-54 adrenoceptor alpha 1D Homo sapiens 81-88 16509586-1 2006 We derived homology models for all human catecholamine-binding GPCRs (CABRs; the alpha-1, alpha-2, and beta-adrenoceptors and the D1-type and D2-type dopamine receptor) using the bovine rhodopsin-11-cis-retinal X-ray structure. Catecholamines 41-54 rhodopsin Bos taurus 186-195 16291925-10 2006 These results show that adenosine and catecholamine analogs activate sperm motility by mechanisms that require extracellular Ca2+, the atypical sperm adenylyl cyclase, cAMP, and protein kinase A. Catecholamines 38-51 cathelicidin antimicrobial peptide Mus musculus 168-194 16892369-1 2006 Inhibition of the enzyme catechol O-methyltransferase offers a therapeutic handle to regulate the catabolism of catecholamine neurotransmitters, providing valuable assistance in the treatment of CNS disorders such as Parkinson"s disease. Catecholamines 112-125 catechol-O-methyltransferase Homo sapiens 25-53 16636975-3 2006 In healthy subjects, an inhibitory effect of acute catecholamine elevation on the leptin plasma concentrations has been reported. Catecholamines 51-64 leptin Homo sapiens 82-88 16211613-11 2006 The HS1-BP3 gene plays a putative role in regulating catecholamine and serotonin metabolism, but the functional consequences of the amino acid substitution (A265G) caused by this genetic variant is unknown. Catecholamines 53-66 HCLS1 binding protein 3 Homo sapiens 4-11 16289633-3 2006 A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. Catecholamines 112-125 syntaxin 1A Homo sapiens 27-38 16289633-3 2006 A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. Catecholamines 112-125 solute carrier family 6 member 2 Homo sapiens 73-99 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 tyrosine hydroxylase Homo sapiens 229-231 16391984-9 2006 Maximal TnT and aL levels were correlated to duration (r = 0.53, p < 0.01 and r = 0.48, p < 0.02) and dosage (r = 0.52, p < 0.02 and r = 0.60, p < 0.01) of catecholamines and duration of respiratory therapy (r = 0.57, p < 0.01 and r = 0.50, p < 0.02). Catecholamines 168-182 troponin T1, slow skeletal type Homo sapiens 8-11 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 monoamine oxidase A Homo sapiens 234-253 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 monoamine oxidase A Homo sapiens 255-259 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 266-294 16360899-4 2006 In the present study, we investigated the association between personality traits and systematic combination of functional polymorphisms in three genes that regulate the metabolism of catecholamines, namely, tyrosine hydroxylase (TH), monoamine oxidase A (MAOA), and catechol-O-methyltransferase (COMT). Catecholamines 183-197 catechol-O-methyltransferase Homo sapiens 296-300 16462018-3 2006 We have reported that the inactivation of CAs by catechol-O-methyltransferase (COMT) in the liver is important in high blood pressure in spontaneously hypertensive rats (SHR). Catecholamines 42-45 catechol-O-methyltransferase Rattus norvegicus 49-77 16329116-1 2006 The vertebrate hypothalamus and surrounding region contain a large population of cells expressing tyrosine hydroxylase (TH), the rate limiting enzyme for synthesis of dopamine and other catecholamines. Catecholamines 186-200 tyrosine 3-monooxygenase Microtus ochrogaster 98-118 16329116-1 2006 The vertebrate hypothalamus and surrounding region contain a large population of cells expressing tyrosine hydroxylase (TH), the rate limiting enzyme for synthesis of dopamine and other catecholamines. Catecholamines 186-200 tyrosine 3-monooxygenase Microtus ochrogaster 120-122 16339181-8 2006 These data suggest that subjects homozygous for Arg at codon 16 of the beta2AR have reduced and MAP at rest that persist during exercise with no evidence for differential changes over the course of exercise despite large changes in catecholamines. Catecholamines 232-246 adrenoceptor beta 2 Homo sapiens 71-78 16462018-3 2006 We have reported that the inactivation of CAs by catechol-O-methyltransferase (COMT) in the liver is important in high blood pressure in spontaneously hypertensive rats (SHR). Catecholamines 42-45 catechol-O-methyltransferase Rattus norvegicus 79-83 16443756-2 2006 Although fibroblasts express beta2-adrenergic receptors (beta2-AR) and cutaneous keratinocytes can synthesize beta-AR agonists (catecholamines), the functional significance of this hormonal mediator network in the skin has not been addressed. Catecholamines 128-142 adrenoceptor beta 2 Homo sapiens 110-117 16502325-2 2006 1985 Biochim Pharmacol 34, 2605-2609], the interaction resulting in a stimulatory effect on the ceruloplasmin catalyzed oxidation of catecholamines and NADH; the latter used as substrate in the present study. Catecholamines 133-147 ceruloplasmin Homo sapiens 96-109 16542483-4 2006 Beneficial effects of adding vasopressin were observed in other catecholamine-refractory shock states as well, such as vasodilatory shock and haemorrhagic shock. Catecholamines 64-77 arginine vasopressin Homo sapiens 29-40 16352648-3 2006 Since catecholamines play an important role in cardiac (patho)physiology, we wanted to elucidate whether catecholamines may affect expression of Cx43 and Cx40. Catecholamines 105-119 gap junction protein, alpha 1 Rattus norvegicus 145-149 16352648-3 2006 Since catecholamines play an important role in cardiac (patho)physiology, we wanted to elucidate whether catecholamines may affect expression of Cx43 and Cx40. Catecholamines 105-119 gap junction protein, alpha 5 Rattus norvegicus 154-158 16352648-9 2006 Adrenergic stimulation of cardiomyocytes can enhance Cx43 expression thereby increasing cellular coupling, indicating a possible role for catecholamines in the regulation of cardiac gap junction expression in cardiac disease. Catecholamines 138-152 gap junction protein, alpha 1 Rattus norvegicus 53-57 16424707-0 2006 Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock. Catecholamines 91-105 nitric oxide synthase 2, inducible Mus musculus 8-39 16965190-5 2006 Frontal lobe dysfunction and mutations in the catechol O-methyltransferase (COMT) gene involved in dopamine metabolism and catecholamine inactivation have been linked to agitation in patients with schizophrenia and bipolar disorder. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 46-74 16243840-6 2006 Wild-type Akt had no effect on the overall number of exocytotic events, but slowed the kinetics of catecholamine release from individual vesicles, resulting in an increased quantal size. Catecholamines 99-112 AKT serine/threonine kinase 1 Homo sapiens 10-13 16889669-9 2006 The inhibitory effect of catecholamines on IFN-gamma production was lower in RA patients as compared with HDs. Catecholamines 25-39 interferon gamma Homo sapiens 43-52 16889669-14 2006 RA patients demonstrate an impaired inhibitory effect of catecholamines on IFN-gamma production together with a failure to induce a shift of T-cell cytokine responses toward a Th2-like profile. Catecholamines 57-71 interferon gamma Homo sapiens 75-84 16336196-9 2006 The impact of leptin on several equally relevant signalling pathways extends also to Rho family GTPases in relation to the actin cytoskeleton, production of reactive oxygen species, stimulation of prostaglandins, binding to diacylglycerol kinase and catecholamine secretion, among others. Catecholamines 250-263 leptin Homo sapiens 14-20 16402117-4 2006 beta(2)-Adrenoceptor agonists are the most effective bronchodilators and evolved from catecholamines from the adrenal medulla, whereas corticosteroids, from the adrenal cortex, are by far the most effective controllers of the underlying inflammatory process in the airways. Catecholamines 86-100 adrenoceptor beta 2 Homo sapiens 0-20 17032443-1 2006 INTRODUCTION: Arginine vasopressin (AVP) is increasingly used to treat sepsis-related vasodilation and to decrease catecholamine requirements. Catecholamines 115-128 vasopressin-neurophysin 2-copeptin Ovis aries 14-34 17032443-1 2006 INTRODUCTION: Arginine vasopressin (AVP) is increasingly used to treat sepsis-related vasodilation and to decrease catecholamine requirements. Catecholamines 115-128 vasopressin-neurophysin 2-copeptin Ovis aries 36-39 16091956-9 2006 The data suggest that a beta3-adrenoceptor-mediated inhibition of Ca2+-dependent proteolysis participates of the antiproteolytic effect of catecholamines in oxidative muscles. Catecholamines 139-153 adrenoceptor beta 3 Rattus norvegicus 24-42 16552374-10 2006 CONCLUSIONS: These results indicate that CO2 pneumoperitoneum applied with 10 and 15 mm Hg pressure gradually decreases the adrenal medulla TH activity; TH is an indispensable enzyme for the biosynthesis of catecholamines. Catecholamines 207-221 tyrosine hydroxylase Rattus norvegicus 140-142 16552374-10 2006 CONCLUSIONS: These results indicate that CO2 pneumoperitoneum applied with 10 and 15 mm Hg pressure gradually decreases the adrenal medulla TH activity; TH is an indispensable enzyme for the biosynthesis of catecholamines. Catecholamines 207-221 tyrosine hydroxylase Rattus norvegicus 153-155 16445859-10 2006 Catecholamine secretion elicited by depolarization of the SNAP-25 knockdown cells was reduced to 37% of control. Catecholamines 0-13 synaptosome associated protein 25 Rattus norvegicus 58-65 16445859-12 2006 Transient expression of human SNAP-25 in the knockdown cells rescues the deficit in catecholamine secretion. Catecholamines 84-97 synaptosome associated protein 25 Homo sapiens 30-37 16139312-3 2006 Alpha-2 adrenoceptor subtypes and tyrosine hydroxylase, the rate-limiting enzyme of the catecholamine biosynthesis, were studied by Taqman RT-PCR analysis of gene expression in four brain areas of F344 and Lewis rats: hypothalamus, hippocampus, striatum and cortex. Catecholamines 88-101 tyrosine hydroxylase Rattus norvegicus 34-54 16489848-12 2006 In the clinical setting, we observed positive effects of vasopressin in some patients with life-threatening hemorrhagic shock, which had no longer responded to adrenergic catecholamines and fluid resuscitation. Catecholamines 171-185 arginine vasopressin Homo sapiens 57-68 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Catecholamines 0-14 interferon gamma Homo sapiens 42-51 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Catecholamines 0-14 tumor necrosis factor Homo sapiens 53-62 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Catecholamines 0-14 interleukin 10 Homo sapiens 68-73 16889669-6 2006 Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine. Catecholamines 0-14 interferon gamma Homo sapiens 119-128 18543469-3 2006 Among his early pioneering research achievements in applying chemical and biochemical approaches to neuroscience were the discoveries of the painkiller acetaminophen (Tylenol, Paracetamol) and the liver microsomal drug-metabolizing enzymes, and the establishment of catechol-O-methyltransferase as an important enzyme in catecholamine metabolism. Catecholamines 321-334 catechol-O-methyltransferase Homo sapiens 266-294 16677425-0 2006 Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury. Catecholamines 24-37 arginine vasopressin Homo sapiens 9-20 16677425-1 2006 INTRODUCTION: The aim of this study was to assess the efficacy of arginine-vasopressin (AVP) as a rescue therapy in catecholamine-refractory septic and non-septic shock in extremely low birth weight (ELBW) infants with acute renal injury. Catecholamines 116-129 arginine vasopressin Homo sapiens 66-86 16677425-1 2006 INTRODUCTION: The aim of this study was to assess the efficacy of arginine-vasopressin (AVP) as a rescue therapy in catecholamine-refractory septic and non-septic shock in extremely low birth weight (ELBW) infants with acute renal injury. Catecholamines 116-129 arginine vasopressin Homo sapiens 88-91 16677425-4 2006 RESULTS: In all three ELBW infants with catecholamine-resistant septic shock, systemic arterial blood pressure increased substantively with restoration of urine output after AVP administration (dosage, 0.035 to 0.36 U/kg/h; length, 70 +/- 21 hours). Catecholamines 40-53 arginine vasopressin Homo sapiens 174-177 16677425-7 2006 CONCLUSION: AVP may be a promising rescue therapy in catecholamine-resistant shock in ELBW infants with acute renal injury. Catecholamines 53-66 arginine vasopressin Homo sapiens 12-15 16696866-10 2006 This observation may partly explain why AVP is such a potent vasopressor hormone and can increase systemic vascular resistance even in advanced vasodilatory shock unresponsive to increases in standard catecholamine therapy. Catecholamines 201-214 arginine vasopressin Homo sapiens 40-43 16697281-10 2006 VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP Rs mediate this effect, PAC(1)-Rs being coupled to AC, VPAC(1)-Rs to both AC and PLC, and VPAC(2)-Rs only to PLC. Catecholamines 69-83 vasoactive intestinal peptide Homo sapiens 0-3 16697281-10 2006 VIP and PACAP stimulate the synthesis and release of adrenomedullary catecholamines, and all three subtypes of PACAP/VIP Rs mediate this effect, PAC(1)-Rs being coupled to AC, VPAC(1)-Rs to both AC and PLC, and VPAC(2)-Rs only to PLC. Catecholamines 69-83 adenylate cyclase activating polypeptide 1 Homo sapiens 8-13 16697281-11 2006 A privotal role in the catecholamine secretagogue action of VIP and PACAP is played by Ca(2+). Catecholamines 23-36 vasoactive intestinal peptide Homo sapiens 60-63 16697281-11 2006 A privotal role in the catecholamine secretagogue action of VIP and PACAP is played by Ca(2+). Catecholamines 23-36 adenylate cyclase activating polypeptide 1 Homo sapiens 68-73 16965190-5 2006 Frontal lobe dysfunction and mutations in the catechol O-methyltransferase (COMT) gene involved in dopamine metabolism and catecholamine inactivation have been linked to agitation in patients with schizophrenia and bipolar disorder. Catecholamines 123-136 catechol-O-methyltransferase Homo sapiens 76-80 16781084-12 2006 Moreover, catecholamines and certain PIC inhibit lipoprotein lipase, a fat synthesizing enzyme. Catecholamines 10-24 lipoprotein lipase Homo sapiens 49-67 17017516-3 2006 In the present paper we focus on the role of the pre-synaptic protein alpha-synuclein in altering the proteasom based on the results emerging from experimental models showing a mechanistic chain of events between altered alpha-synuclein, proteasome impairment and formation of neuronal inclusions and catecholamine cell death. Catecholamines 301-314 synuclein alpha Homo sapiens 70-85 17329957-2 2006 A tetranucleotide repeat polymorphism in the first intron of the tyrosine hydroxylase (TH) gene, encoding a rate-limiting enzyme for the synthesis of catecholamines, is reported to have the potential to control expression of the gene and to be associated with suicidal behavior in patients with adjustment disorders. Catecholamines 150-164 tyrosine hydroxylase Homo sapiens 65-85 17329957-2 2006 A tetranucleotide repeat polymorphism in the first intron of the tyrosine hydroxylase (TH) gene, encoding a rate-limiting enzyme for the synthesis of catecholamines, is reported to have the potential to control expression of the gene and to be associated with suicidal behavior in patients with adjustment disorders. Catecholamines 150-164 tyrosine hydroxylase Homo sapiens 87-89 16336625-8 2006 When erythropoietin was administered to mice unilaterally lesioned with 6-hydroxydopamine, it prevented the loss of nigral dopaminergic neurons and maintained striatal catecholamine levels for at least 8 weeks. Catecholamines 168-181 erythropoietin Mus musculus 5-19 17135716-1 2006 Tyrosine hydroxylase (TH), the first and limiting enzyme for catecholamine synthesis, has been identified immunohistochemically (IHC) in human neurosecretory neurons where it is found to colocalize with vasopressin (AVP) or oxytocin. Catecholamines 61-74 tyrosine hydroxylase Homo sapiens 0-20 16288991-1 2006 Aromatic l-aminoacid decarboxylase (AADC) deficiency is a neurotransmitter defect leading to a combined deficiency of catecholamines and serotonin. Catecholamines 118-132 dopa decarboxylase Homo sapiens 36-40 17028449-10 2006 CONCLUSIONS: These findings seem to suggest that a turnover of catecholamines, connected with polymorphism determining high activity of COMT enzyme, is connected with the risk of ED occurrence, particularly anorexia nervosa. Catecholamines 63-77 catechol-O-methyltransferase Homo sapiens 136-140 17135716-1 2006 Tyrosine hydroxylase (TH), the first and limiting enzyme for catecholamine synthesis, has been identified immunohistochemically (IHC) in human neurosecretory neurons where it is found to colocalize with vasopressin (AVP) or oxytocin. Catecholamines 61-74 tyrosine hydroxylase Homo sapiens 22-24 17135716-1 2006 Tyrosine hydroxylase (TH), the first and limiting enzyme for catecholamine synthesis, has been identified immunohistochemically (IHC) in human neurosecretory neurons where it is found to colocalize with vasopressin (AVP) or oxytocin. Catecholamines 61-74 arginine vasopressin Homo sapiens 203-214 17135716-3 2006 Since GTP cyclohydrolase I (GCHI), the first enzyme for tetrahydrobiopterin synthesis, the essential cofactor of TH, and aromatic L-amino acid decarboxylase (AADC) have so far not been detected in neurosecretory neurons, the functional role of TH in catecholamine synthesis is still questionable. Catecholamines 250-263 GTP cyclohydrolase 1 Homo sapiens 28-32 16515844-4 2006 Norepinephrine transporter-deficient mice have increased circulating catecholamines and elevated heart rate and blood pressure. Catecholamines 69-83 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 0-26 16515844-12 2006 Therefore, while reduced catecholamine clearance amplifies immediate cardiovascular responses to anxiety- or fear-inducing stimuli in norepinephrine transporter-/- mice, norepinephrine transporter deficiency apparently prevents protracted hemodynamic escalation in a fearful environment. Catecholamines 25-38 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 134-196 17135716-3 2006 Since GTP cyclohydrolase I (GCHI), the first enzyme for tetrahydrobiopterin synthesis, the essential cofactor of TH, and aromatic L-amino acid decarboxylase (AADC) have so far not been detected in neurosecretory neurons, the functional role of TH in catecholamine synthesis is still questionable. Catecholamines 250-263 tyrosine hydroxylase Homo sapiens 113-115 17135716-3 2006 Since GTP cyclohydrolase I (GCHI), the first enzyme for tetrahydrobiopterin synthesis, the essential cofactor of TH, and aromatic L-amino acid decarboxylase (AADC) have so far not been detected in neurosecretory neurons, the functional role of TH in catecholamine synthesis is still questionable. Catecholamines 250-263 dopa decarboxylase Homo sapiens 158-162 16002223-4 2006 Our aim was to assess/evaluate a possible relationship between salivary alpha-amylase and adrenergic parameters, i.e. catecholamines, as well as other stress markers. Catecholamines 118-132 amylase alpha 1A Homo sapiens 63-85 16686426-9 2006 Rat PC12 cells share properties with O2-sensing glomus cells of the carotid body, including hypoxia-inducible expression of tyrosine hydroxylase, the rate limiting enzyme for catecholamine biosynthesis. Catecholamines 175-188 tyrosine hydroxylase Rattus norvegicus 124-144 16409536-1 2006 Aromatic l-amino acid decarboxylase (AADC) deficiency is characterized by an almost complete absence of sympathetic autoregulation, because of very low levels of circulating catecholamines. Catecholamines 174-188 dopa decarboxylase Homo sapiens 0-35 16409536-1 2006 Aromatic l-amino acid decarboxylase (AADC) deficiency is characterized by an almost complete absence of sympathetic autoregulation, because of very low levels of circulating catecholamines. Catecholamines 174-188 dopa decarboxylase Homo sapiens 37-41 16236416-2 2006 Several lines of evidence support the interaction between brain angiotensins and central catecholamine systems, and suggest that angiotensin I-converting enzyme (ACE) may be a reasonable candidate gene for psychiatric disorders. Catecholamines 89-102 angiotensin I converting enzyme Homo sapiens 162-165 16755607-1 2006 Desorption/ionization from porous silicon dioxide (DIOSD), in combination with a standard matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) instrument, was used for the identification of catecholamines in the human peripheral blood lymphocytes. Catecholamines 208-222 FEZ family zinc finger 2 Homo sapiens 156-159 16866305-5 2006 In this present paper, data regarding distribution of catecholamine synthesising enzymes and some neuropeptides, as well as their gene expression during development in the rodent and porcine brain are summarised and related to development of LHRH-containing structures. Catecholamines 54-67 gonadotropin releasing hormone 1 Rattus norvegicus 242-246 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 0-28 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 30-34 16047163-2 2005 The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) were used as catecholamine biosynthetic markers and chromogranin A (CGA) as a marker for secretory granules. Catecholamines 101-114 phenylethanolamine N-methyltransferase Homo sapiens 82-86 16137646-7 2005 Among the most significantly up-regulated genes in DGKepsilon (+/+) mice included those encoding the inducible prostaglandin synthase cyclooxygenase-2 (COX-2) and tyrosine hydroxylase (TH), also known as tyrosine 3-monooxygenase, the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 258-271 diacylglycerol kinase, epsilon Mus musculus 51-61 16137646-7 2005 Among the most significantly up-regulated genes in DGKepsilon (+/+) mice included those encoding the inducible prostaglandin synthase cyclooxygenase-2 (COX-2) and tyrosine hydroxylase (TH), also known as tyrosine 3-monooxygenase, the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 258-271 prostaglandin-endoperoxide synthase 2 Mus musculus 134-150 16137646-7 2005 Among the most significantly up-regulated genes in DGKepsilon (+/+) mice included those encoding the inducible prostaglandin synthase cyclooxygenase-2 (COX-2) and tyrosine hydroxylase (TH), also known as tyrosine 3-monooxygenase, the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 258-271 prostaglandin-endoperoxide synthase 2 Mus musculus 152-157 16137646-9 2005 These data, plus our previous findings that DGKepsilon (-/-) mice show higher resistance to electroconvulsive shock, suggest an interplay between and regulatory role for DGKepsilon, COX-2, and catecholamine signaling during kindling epileptogenesis. Catecholamines 193-206 diacylglycerol kinase, epsilon Mus musculus 44-54 16253764-3 2005 This polymorphism has been the subject of intense molecular epidemiological studies because of the important role of COMT in the metabolism of catecholamines and catechol estrogens. Catecholamines 143-157 catechol-O-methyltransferase Homo sapiens 117-121 17319465-8 2006 Replacement doses of hydrocortisone and vasopressin may reduce mortality and improve hypotension, respectively, in a subgroup of patients with catecholamine-refractory septic shock. Catecholamines 143-156 arginine vasopressin Homo sapiens 40-51 16105653-1 2005 Tyrosine 3-monooxygenase (tyrosine hydroxylase, TH) catalyzes the initial and rate-limiting step in the catecholamine biosynthesis. Catecholamines 104-117 tyrosine hydroxylase Mus musculus 0-24 16216265-14 2005 Thus, absence of insulin receptor signaling in the cardiac myocyte worsens catecholamine-mediated myocardial injury, at least in part, via mechanisms that tend to impair myocardial blood flow and increase ischemic injury. Catecholamines 75-88 insulin receptor Mus musculus 17-33 16273345-11 2005 It increases responsiveness to the adrenergic beta receptor stimulation of lipolysis and to the antilipolytic action of catecholamines mediated by ADRA2As. Catecholamines 120-134 adrenoceptor alpha 2A Homo sapiens 147-152 16375695-3 2005 Acute regulation of PEPCK is achieved by modulating transcription of the gene, which is tightly regulated by cAMP (the mediator of glucagon and catecholamines), glucocorticoids and insulin. Catecholamines 144-158 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 20-25 16375695-4 2005 Normally, PEPCK expression is induced by glucagon, catecholamines and glucocorticoids during periods of fasting and in response to stress, but is dominantly inhibited by glucose-induced increases in insulin secretion upon feeding. Catecholamines 51-65 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 10-15 16410663-2 2005 Catecholamines are known stimulants of PTH secretion. Catecholamines 0-14 parathyroid hormone Homo sapiens 39-42 16255662-2 2005 Vasopressin infusions are currently used as rescue therapy for the treatment of vasodilatory, catecholamine-resistant septic shock. Catecholamines 94-107 arginine vasopressin Homo sapiens 0-11 16026927-0 2005 Contribution of catechol O-methyltransferase to the removal of accumulated interstitial catecholamines evoked by myocardial ischemia. Catecholamines 88-102 catechol O-methyltransferase Oryctolagus cuniculus 16-44 16026927-1 2005 Catechol O-methyltransferase (COMT) plays an important role for clearance of high catecholamine levels. Catecholamines 82-95 catechol O-methyltransferase Oryctolagus cuniculus 0-28 16026927-1 2005 Catechol O-methyltransferase (COMT) plays an important role for clearance of high catecholamine levels. Catecholamines 82-95 catechol O-methyltransferase Oryctolagus cuniculus 30-34 16026927-3 2005 We examined how COMT activity affects myocardial catecholamine levels during myocardial ischemia and reperfusion. Catecholamines 49-62 catechol O-methyltransferase Oryctolagus cuniculus 16-20 16026927-13 2005 These data suggest that cardiac COMT activity influences on the removal of accumulated catecholamine during myocardial ischemia. Catecholamines 87-100 catechol O-methyltransferase Oryctolagus cuniculus 32-36 16000336-3 2005 Using immunohistochemistry for alpha-synuclein, we confirmed the concentration of this protein in the soma of normal A9 neurons and in Lewy body pathology in brainstem catecholamine neurons in Parkinson"s disease. Catecholamines 168-181 synuclein alpha Homo sapiens 31-46 15973733-1 2005 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and, thus, critical in determining the catecholaminergic phenotype. Catecholamines 74-88 tyrosine hydroxylase Mus musculus 0-20 15973733-1 2005 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and, thus, critical in determining the catecholaminergic phenotype. Catecholamines 74-88 tyrosine hydroxylase Mus musculus 22-24 16249444-4 2005 In human adipocytes, catecholamine- and natriuretic peptide-induced lipolysis were completely blunted by the HSL inhibitor. Catecholamines 21-34 lipase E, hormone sensitive type Homo sapiens 109-112 16249444-9 2005 In conclusion, HSL is the major lipase for catecholamine- and natriuretic peptide-stimulated lipolysis, whereas ATGL mediates the hydrolysis of triglycerides during basal lipolysis. Catecholamines 43-56 lipase E, hormone sensitive type Homo sapiens 15-18 16219424-0 2005 Inhibition of the RhoA/Rho kinase system attenuates catecholamine biosynthesis in PC 12 rat pheochromocytoma cells. Catecholamines 52-65 ras homolog family member A Rattus norvegicus 18-22 16268952-12 2005 Insulin injection increased plasma catecholamines on the average by 21.5% and 53.4% for adrenaline and noradrenaline respectively. Catecholamines 35-49 insulin Gallus gallus 0-7 16268952-15 2005 Contrary to this, rT3 enhanced the rise of plasma catecholamines due to insulin treatment. Catecholamines 50-64 insulin Gallus gallus 72-79 16163519-1 2005 RATIONALE: Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE), thus playing a critical role in catecholamine metabolism. Catecholamines 122-135 dopamine beta hydroxylase Mus musculus 11-36 16163519-1 2005 RATIONALE: Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE), thus playing a critical role in catecholamine metabolism. Catecholamines 122-135 dopamine beta hydroxylase Mus musculus 38-41 16219424-10 2005 Thus, we propose that activation of RhoA, and its downstream effecter Rho-kinase, is a prerequisite for catecholamine biosynthesis in PC12 cells. Catecholamines 104-117 ras homolog family member A Rattus norvegicus 36-40 16219424-10 2005 Thus, we propose that activation of RhoA, and its downstream effecter Rho-kinase, is a prerequisite for catecholamine biosynthesis in PC12 cells. Catecholamines 104-117 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 70-80 15977304-5 2005 These may include insulin-antagonistic action of hormones like catecholamines, glucocorticoids, sex steroids and adipokines as well as dysregulation of autonomic nervous activity and they could contribute to the early development of insulin resistance. Catecholamines 63-77 insulin Homo sapiens 18-25 16358768-0 2005 [Catecholamines in regulation of development of GnRH neurons of rat fetuses]. Catecholamines 1-15 gonadotropin releasing hormone 1 Rattus norvegicus 48-52 16358768-6 2005 The GnRH concentration in the caudal areas of migration of GnRH-neurons under the normal conditions and in the case of catecholamine deficiency was determined using radioimmunoassay. Catecholamines 119-132 gonadotropin releasing hormone 1 Rattus norvegicus 4-8 16358768-8 2005 The data obtained suggest the involvement of catecholamines in the regulation of development of GnRH-Neurons during prenatal development. Catecholamines 45-59 gonadotropin releasing hormone 1 Rattus norvegicus 96-100 16219424-7 2005 TH catalyzes the rate-limiting step in the biosynthesis of catecholamine. Catecholamines 59-72 tyrosine hydroxylase Rattus norvegicus 0-2 16215614-4 2005 Furthermore, variability in an enzyme-degrading catecholamines (COMT gene) may also alter the efficacy of morphine, which shows that genetic variability in non-opioid systems may indirectly influence the clinical opioid efficacy. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 64-68 16085361-5 2005 Therefore, we hypothesized that catecholamines released from PC12 cells may induce p62 expression. Catecholamines 32-46 KH RNA binding domain containing, signal transduction associated 1 Rattus norvegicus 83-86 16166648-5 2005 We found that syt I and VII partially colocalize on large dense core vesicles and that upregulation of syt VII produces a concomitant increase in the divalent cation sensitivity of catecholamine release from PC12 cells. Catecholamines 181-194 synaptotagmin 7 Rattus norvegicus 103-110 16273918-10 2005 Changes in plasma CgA concentration were correlated with changes in plasma cortisol or catecholamine concentrations of hypoglycemic dogs. Catecholamines 87-100 chromogranin-A Canis lupus familiaris 18-21 16132951-15 2005 ARC/VMH DN-AMPK overexpression impaired early counter-regulation, as evidenced by reduced glucagon and catecholamine responses. Catecholamines 103-116 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 11-15 16021468-4 2005 ASCL1 was considered as a candidate interacting partner of PHOX2B, as ASCL1 is a transcription factor that co-regulates catecholamine-synthesizing enzymes with PHOX2B. Catecholamines 120-133 achaete-scute family bHLH transcription factor 1 Homo sapiens 0-5 16021468-4 2005 ASCL1 was considered as a candidate interacting partner of PHOX2B, as ASCL1 is a transcription factor that co-regulates catecholamine-synthesizing enzymes with PHOX2B. Catecholamines 120-133 paired like homeobox 2B Homo sapiens 59-65 16021468-4 2005 ASCL1 was considered as a candidate interacting partner of PHOX2B, as ASCL1 is a transcription factor that co-regulates catecholamine-synthesizing enzymes with PHOX2B. Catecholamines 120-133 achaete-scute family bHLH transcription factor 1 Homo sapiens 70-75 16021468-4 2005 ASCL1 was considered as a candidate interacting partner of PHOX2B, as ASCL1 is a transcription factor that co-regulates catecholamine-synthesizing enzymes with PHOX2B. Catecholamines 120-133 paired like homeobox 2B Homo sapiens 160-166 16154435-0 2005 Increased plasma adiponectin concentrations in poorly controlled patients with phenylketonuria normalize with a strict diet: evidence for catecholamine-mediated adiponectin regulation and a complex effect of phenylketonuria diet on atherogenesis risk factors. Catecholamines 138-151 adiponectin, C1Q and collagen domain containing Homo sapiens 17-28 16154435-0 2005 Increased plasma adiponectin concentrations in poorly controlled patients with phenylketonuria normalize with a strict diet: evidence for catecholamine-mediated adiponectin regulation and a complex effect of phenylketonuria diet on atherogenesis risk factors. Catecholamines 138-151 adiponectin, C1Q and collagen domain containing Homo sapiens 161-172 16154435-7 2005 These data support the hypothesis that catecholamines inhibit Adpn secretion and that the elevated Adpn of the poorly controlled patients might moderate their risk for endothelial dysfunction and atherogenesis. Catecholamines 39-53 adiponectin, C1Q and collagen domain containing Homo sapiens 62-66 16146482-0 2005 Sublingual microcirculatory flow is impaired by the vasopressin-analogue terlipressin in a patient with catecholamine-resistant septic shock. Catecholamines 104-117 arginine vasopressin Homo sapiens 52-63 16142389-1 2005 The human beta-2 adrenergic receptor (beta2AR) is responsible for the binding of endogenous catecholamines and their exogenously administered agonists and antagonists. Catecholamines 92-106 adrenoceptor beta 2 Homo sapiens 10-36 16142389-1 2005 The human beta-2 adrenergic receptor (beta2AR) is responsible for the binding of endogenous catecholamines and their exogenously administered agonists and antagonists. Catecholamines 92-106 adrenoceptor beta 2 Homo sapiens 38-45 16210796-1 2005 Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH). Catecholamines 31-44 tyrosine hydroxylase Canis lupus familiaris 113-133 15855228-9 2005 UCP2, GR, 11beta-HSD1 and -2 mRNA, plus VDAC and cytochrome c protein abundance were all significantly correlated with fetal plasma cortisol and catecholamine levels, but not thyroid hormone concentrations, in the lung and BAT of UCC fetuses. Catecholamines 145-158 mitochondrial uncoupling protein 2 Ovis aries 0-4 15855228-9 2005 UCP2, GR, 11beta-HSD1 and -2 mRNA, plus VDAC and cytochrome c protein abundance were all significantly correlated with fetal plasma cortisol and catecholamine levels, but not thyroid hormone concentrations, in the lung and BAT of UCC fetuses. Catecholamines 145-158 LOC101107954 Ovis aries 49-61 16116000-2 2005 Both patients responded to a small-dose infusion of vasopressin, which allowed tapering off of the catecholamines. Catecholamines 99-113 arginine vasopressin Homo sapiens 52-63 16116000-3 2005 The possible role of small-dose infusions of vasopressin in fluid- and catecholamine-resistant hemorrhagic shock is discussed. Catecholamines 71-84 arginine vasopressin Homo sapiens 45-56 16175498-6 2005 In addition the proinflammatory cytokine, IL-6 is also activated, probably via catecholamines. Catecholamines 79-93 interleukin 6 Homo sapiens 42-46 16286511-1 2005 The beta2-adrenoceptor gene may be of particular importance for human obesity because catecholamines have a central role in energy expenditure both as neurotransmitters and hormones. Catecholamines 86-100 adrenoceptor beta 2 Homo sapiens 4-22 16296341-3 2005 Thus, the discussion that follows will mainly focus on our data, including: 1) leptin as well Ang II subtype-2 receptor (AT2), assumed to be a key molecule for metabolic syndrome, much involved in regulating catecholamine synthesis and secretion. Catecholamines 208-221 angiotensin II receptor type 2 Homo sapiens 94-119 16296341-3 2005 Thus, the discussion that follows will mainly focus on our data, including: 1) leptin as well Ang II subtype-2 receptor (AT2), assumed to be a key molecule for metabolic syndrome, much involved in regulating catecholamine synthesis and secretion. Catecholamines 208-221 angiotensin II receptor type 2 Homo sapiens 121-124 16052322-2 2005 Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Catecholamines 71-85 tyrosine hydroxylase Homo sapiens 95-115 16052322-2 2005 Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Catecholamines 71-85 tyrosine hydroxylase Homo sapiens 117-119 16052322-2 2005 Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Catecholamines 71-85 dopa decarboxylase Homo sapiens 157-161 16052322-2 2005 Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Catecholamines 71-85 dopamine beta-hydroxylase Homo sapiens 164-189 16052322-2 2005 Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Catecholamines 71-85 dopamine beta-hydroxylase Homo sapiens 191-194 16052322-2 2005 Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Catecholamines 71-85 phenylethanolamine N-methyltransferase Homo sapiens 200-239 16052322-2 2005 Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Catecholamines 71-85 phenylethanolamine N-methyltransferase Homo sapiens 241-245 16052322-3 2005 Tyrosine hydroxylase, the key enzyme of the biosynthesis of catecholamines, was localized to Leydig cells both at the transcript level (by RT-PCR analyses and by in situ hybridization assays) and at the protein level (by immunoblotting and by immunohistochemistry). Catecholamines 60-74 tyrosine hydroxylase Homo sapiens 0-20 15985485-9 2005 CONCLUSIONS: Polymorphism in the usf1 gene is associated with increased lipolytic effect of catecholamines in fat cells, which is localized at the postadrenoceptor level, possibly, at least, involving protein kinase A. Catecholamines 92-106 upstream transcription factor 1 Homo sapiens 33-37 16210796-1 2005 Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH). Catecholamines 31-44 tyrosine hydroxylase Canis lupus familiaris 135-137 16210796-1 2005 Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH). Catecholamines 31-44 dopamine beta-hydroxylase Canis lupus familiaris 143-169 16210796-1 2005 Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH). Catecholamines 31-44 dopamine beta-hydroxylase Canis lupus familiaris 171-174 15913575-4 2005 Catecholamines, released into the body fluids during emotional or physical stress, activate Ca2+-induced Ca2+ release by protein kinase A-mediated phosphorylation of RyR2. Catecholamines 0-14 ryanodine receptor 2 Homo sapiens 166-170 16009379-5 2005 Immunoblotting study of p38-MAPK expression under identical conditions showed significant alterations in ST, HC, HT and PM (p<0.05) correlated with the changes of catecholamines (DA and E). Catecholamines 166-180 mitogen activated protein kinase 14 Rattus norvegicus 24-27 15985215-2 2005 The Mk and Ptn genes are essential for normal development of the catecholamine and renin-angiotensin pathways and the synthesis of different collagens. Catecholamines 65-78 pleiotrophin Mus musculus 11-14 16079507-1 2005 R-(-)-1-(Benzofuran-2-yl)-2-propylaminopentane [R-(-)-BPAP] enhances electric field stimulation-induced release of catecholamine from isolated brain stem and ameliorates motor deficits in rats. Catecholamines 115-128 ribonuclease A family member 3 Rattus norvegicus 0-7 16045647-4 2005 Furthermore, variability in an enzyme degrading catecholamines (COMT gene) alters the efficacy of morphine demonstrating that genetic variability in non-opioid systems may indirectly influence the clinical efficacy from morphine. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 64-68 16187166-3 2005 Fundamental regulation of dopamine occurs via tyrosine hydroxylase (TH), the first and rate-limiting enzyme in the catecholamine biosynthetic pathway. Catecholamines 115-128 pale Drosophila melanogaster 46-66 16187166-3 2005 Fundamental regulation of dopamine occurs via tyrosine hydroxylase (TH), the first and rate-limiting enzyme in the catecholamine biosynthetic pathway. Catecholamines 115-128 pale Drosophila melanogaster 68-70 15946989-5 2005 MAO-A is the primary enzyme metabolizing catecholamines and dietary amines, and its role in skeletal muscle remains largely unexplored. Catecholamines 41-55 monoamine oxidase A Homo sapiens 0-5 16138261-0 2005 Intranasal administration of ACTH(1-24) stimulates catecholamine secretion. Catecholamines 51-64 proopiomelanocortin Homo sapiens 29-33 16049171-2 2005 Chromogranin A (CgA), which binds catecholamines for storage in the lumen of chromaffin granules, has been shown to be involved in DCG biogenesis in neuroendocrine PC12 cells. Catecholamines 34-48 chromogranin A Rattus norvegicus 0-14 16087723-2 2005 These latter findings reveal that the alpha(2A) AR subtype regulates glucose-stimulated insulin release in response to endogenous catecholamines in vivo. Catecholamines 130-144 adrenergic receptor, alpha 2a Mus musculus 38-50 16087723-5 2005 The present studies document the important role of the alpha(2A) AR subtype in tonic suppression of insulin release in response to endogenous catecholamines as well as exogenous alpha(2) agonists and provide insights into pleiotropic changes that result from loss of alpha(2A) AR expression and tonic suppression of insulin release. Catecholamines 142-156 adrenergic receptor, alpha 2a Mus musculus 55-67 15894713-2 2005 The norepinephrine transporter (NET) mediates reuptake of released catecholamines, thus playing a role in the limitation of signaling strength in the central and peripheral nervous systems. Catecholamines 67-81 solute carrier family 6 member 2 Homo sapiens 4-30 15894713-2 2005 The norepinephrine transporter (NET) mediates reuptake of released catecholamines, thus playing a role in the limitation of signaling strength in the central and peripheral nervous systems. Catecholamines 67-81 solute carrier family 6 member 2 Homo sapiens 32-35 16079252-0 2005 Activin A stimulates catecholamine secretion from rat adrenal chromaffin cells: a new physiological mechanism. Catecholamines 21-34 inhibin subunit beta A Rattus norvegicus 0-9 16079252-2 2005 We aimed to find whether activin A induces secretion of catecholamines from chromaffin cells of the adrenal medulla, which neighbours the adrenal cortex in vivo. Catecholamines 56-70 inhibin subunit beta A Rattus norvegicus 25-34 16079252-4 2005 Activin A stimulated catecholamine secretion in a rapid and dose-dependent manner from chromaffin cells. Catecholamines 21-34 inhibin subunit beta A Rattus norvegicus 0-9 16079252-9 2005 We conclude from these findings that activin A is capable of stimulating a robust level of catecholamine secretion from adrenal chromaffin cells in a concentration-dependent manner. Catecholamines 91-104 inhibin subunit beta A Rattus norvegicus 37-46 15993445-4 2005 Pre-treatment with naloxone methiodide decreased (15%) IL-1beta-induced Fos-immunoreactivity (Fos-IR) in medial parvocellular paraventricular nucleus (mPVN) corticotropin-releasing hormone (CRH) neurons but increased responses in the ventrolateral medulla (VLM) C1 (65%) and nucleus tractus solitarius (NTS) A2 (110%) catecholamine cell groups and area postrema (136%). Catecholamines 318-331 interleukin 1 beta Rattus norvegicus 55-63 15993445-4 2005 Pre-treatment with naloxone methiodide decreased (15%) IL-1beta-induced Fos-immunoreactivity (Fos-IR) in medial parvocellular paraventricular nucleus (mPVN) corticotropin-releasing hormone (CRH) neurons but increased responses in the ventrolateral medulla (VLM) C1 (65%) and nucleus tractus solitarius (NTS) A2 (110%) catecholamine cell groups and area postrema (136%). Catecholamines 318-331 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 94-97 15993445-7 2005 Similar comparisons also detected decreases in Fos-IR neurons induced by IL-1beta in the VLM A1, VLM C1 and NTS A2 catecholamine cell groups, area postrema, and parabrachial nucleus. Catecholamines 115-128 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 47-50 15993445-7 2005 Similar comparisons also detected decreases in Fos-IR neurons induced by IL-1beta in the VLM A1, VLM C1 and NTS A2 catecholamine cell groups, area postrema, and parabrachial nucleus. Catecholamines 115-128 interleukin 1 beta Mus musculus 73-81 16108138-8 2005 Dopa decarboxylase (Ddc) encodes the enzyme that catalyses the final step in the synthesis of dopamine, a major Drosophila catecholamine and neurotransmitter. Catecholamines 123-136 Dopa decarboxylase Drosophila melanogaster 0-18 16108138-8 2005 Dopa decarboxylase (Ddc) encodes the enzyme that catalyses the final step in the synthesis of dopamine, a major Drosophila catecholamine and neurotransmitter. Catecholamines 123-136 Dopa decarboxylase Drosophila melanogaster 20-23 16049171-2 2005 Chromogranin A (CgA), which binds catecholamines for storage in the lumen of chromaffin granules, has been shown to be involved in DCG biogenesis in neuroendocrine PC12 cells. Catecholamines 34-48 chromogranin A Rattus norvegicus 16-19 16049171-7 2005 These data indicate an essential role of CgA in regulating chromaffin DCG biogenesis and catecholamine storage in vivo. Catecholamines 89-102 chromogranin A Mus musculus 41-44 15996692-1 2005 It is well established that peripheral administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS) can activate the hypothalamo-pituitary-adrenocortical (HPA) axis, alter brain catecholamine and indoleamine metabolism, and affect behavior. Catecholamines 185-198 interleukin 1 complex Mus musculus 57-76 15860534-14 2005 In contrast, CGRP antagonism markedly diminished the femoral vasoconstrictor and glycaemic responses to hypoxaemia, and attenuated the increases in haemoglobin, catecholamines and NPY. Catecholamines 161-175 calcitonin-like Ovis aries 13-17 15927700-1 2005 The purpose of the present study was to determine whether the activation of NPY receptors alters catecholamines (CA) synthesis in the central nervous system and, if so, to identify the NPY receptor subtype(s) mediating this effect. Catecholamines 97-111 neuropeptide Y Rattus norvegicus 76-79 15996692-1 2005 It is well established that peripheral administration of interleukin-1 (IL-1) and lipopolysaccharide (LPS) can activate the hypothalamo-pituitary-adrenocortical (HPA) axis, alter brain catecholamine and indoleamine metabolism, and affect behavior. Catecholamines 185-198 toll-like receptor 4 Mus musculus 102-105 15996692-4 2005 In the present study, the IL-1beta- and LPS-induced changes in certain behaviors, HPA axis activation, and catecholamine and indoleamine metabolism were studied in mice following subdiaphragmatic vagotomy. Catecholamines 107-120 toll-like receptor 4 Mus musculus 40-43 15976236-8 2005 Catecholamines also enhanced the expression of iNOS, CAT-1, and CAT-2A but not CAT-2 or CAT-2B in LPS-stimulated macrophages. Catecholamines 0-14 nitric oxide synthase 2, inducible Mus musculus 47-51 15976236-8 2005 Catecholamines also enhanced the expression of iNOS, CAT-1, and CAT-2A but not CAT-2 or CAT-2B in LPS-stimulated macrophages. Catecholamines 0-14 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 Mus musculus 53-58 15976236-0 2005 Catecholamines" enhancement of inducible nitric oxide synthase-induced nitric oxide biosynthesis involves CAT-1 and CAT-2A. Catecholamines 0-14 nitric oxide synthase 2, inducible Mus musculus 31-62 15976236-0 2005 Catecholamines" enhancement of inducible nitric oxide synthase-induced nitric oxide biosynthesis involves CAT-1 and CAT-2A. Catecholamines 0-14 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 Mus musculus 106-111 15976236-8 2005 Catecholamines also enhanced the expression of iNOS, CAT-1, and CAT-2A but not CAT-2 or CAT-2B in LPS-stimulated macrophages. Catecholamines 0-14 dominant cataract 2 Mus musculus 64-69 15976236-1 2005 Catecholamines enhance inducible nitric oxide synthase (iNOS) expression that results in nitric oxide (NO) overproduction in lipopolysaccharide (LPS)-stimulated macrophages. Catecholamines 0-14 nitric oxide synthase 2, inducible Mus musculus 23-54 15976236-1 2005 Catecholamines enhance inducible nitric oxide synthase (iNOS) expression that results in nitric oxide (NO) overproduction in lipopolysaccharide (LPS)-stimulated macrophages. Catecholamines 0-14 nitric oxide synthase 2, inducible Mus musculus 56-60 15976236-1 2005 Catecholamines enhance inducible nitric oxide synthase (iNOS) expression that results in nitric oxide (NO) overproduction in lipopolysaccharide (LPS)-stimulated macrophages. Catecholamines 0-14 toll-like receptor 4 Mus musculus 145-148 15976236-8 2005 Catecholamines also enhanced the expression of iNOS, CAT-1, and CAT-2A but not CAT-2 or CAT-2B in LPS-stimulated macrophages. Catecholamines 0-14 toll-like receptor 4 Mus musculus 98-101 15976236-11 2005 Furthermore, this catecholamine-enhanced L-arginine transport might involve CAT-1 and CAT-2A but not CAT-2 or CAT-2B. Catecholamines 18-31 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 Mus musculus 76-81 15976236-11 2005 Furthermore, this catecholamine-enhanced L-arginine transport might involve CAT-1 and CAT-2A but not CAT-2 or CAT-2B. Catecholamines 18-31 dominant cataract 2 Mus musculus 86-91 16007250-3 2005 present in vivo evidence for 2 important functions of CHGA: the regulation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal gland and the control of blood pressure. Catecholamines 78-91 chromogranin A Homo sapiens 54-58 15935994-10 2005 The COMT Val(108/158)Met polymorphism modifies the severity of endophenotypes for schizophrenia, indicating that impaired catecholamine regulation contributes to neuropsychiatric risk in 22q11DS. Catecholamines 122-135 catechol-O-methyltransferase Homo sapiens 4-8 15895407-7 2005 GFP was found in retinal cells that expressed TH or phenylethanolamine N-methyl-transferase (PNMT), the first and last enzymes for synthesis of catecholamine, respectively. Catecholamines 144-157 phenylethanolamine N-methyltransferase Danio rerio 52-91 15895407-7 2005 GFP was found in retinal cells that expressed TH or phenylethanolamine N-methyl-transferase (PNMT), the first and last enzymes for synthesis of catecholamine, respectively. Catecholamines 144-157 phenylethanolamine N-methyltransferase Danio rerio 93-97 16001320-7 2005 Overall, the sometimes desperate clinical situation has led to a large number of case reports und uncontrolled series of retrospectively analysed cases, where vasopressin or methylenblue were discribed as successfully reversing catecholamine resistent hypotension. Catecholamines 228-241 arginine vasopressin Homo sapiens 159-170 16007257-4 2005 Chga mice displayed extreme phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c) loss of diurnal BP variation; (d) increased left ventricular mass and cavity dimensions; (e) decreased adrenal catecholamine, neuropeptide Y (Npy), and ATP contents; (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholamine and Npy levels. Catecholamines 310-323 chromogranin A Mus musculus 0-4 16007257-4 2005 Chga mice displayed extreme phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c) loss of diurnal BP variation; (d) increased left ventricular mass and cavity dimensions; (e) decreased adrenal catecholamine, neuropeptide Y (Npy), and ATP contents; (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholamine and Npy levels. Catecholamines 310-323 chromogranin A Mus musculus 0-4 16007250-6 2005 These results suggest a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholamine storage, and catestatin-induced inhibition of cholinergic-stimulated catecholamine release, which regulates autonomic control of blood pressure. Catecholamines 112-125 chromogranin A Homo sapiens 53-57 16007250-6 2005 These results suggest a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholamine storage, and catestatin-induced inhibition of cholinergic-stimulated catecholamine release, which regulates autonomic control of blood pressure. Catecholamines 112-125 chromogranin A Homo sapiens 139-149 16007250-6 2005 These results suggest a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholamine storage, and catestatin-induced inhibition of cholinergic-stimulated catecholamine release, which regulates autonomic control of blood pressure. Catecholamines 195-208 chromogranin A Homo sapiens 139-149 16007257-4 2005 Chga mice displayed extreme phenotypic changes, including: (a) decreased chromaffin granule size and number; (b) elevated BP; (c) loss of diurnal BP variation; (d) increased left ventricular mass and cavity dimensions; (e) decreased adrenal catecholamine, neuropeptide Y (Npy), and ATP contents; (f) increased catecholamine/ATP ratio in the chromaffin granule; and (g) increased plasma catecholamine and Npy levels. Catecholamines 241-254 chromogranin A Mus musculus 0-4 16022583-7 2005 Synthesis of IFN-gamma was induced by all mitogens and could be suppressed by catecholamines (26%-85% reduction). Catecholamines 78-92 interferon gamma Homo sapiens 13-22 16022583-8 2005 In PHA-stimulated PBMCs, IL-4 synthesis was decreased by high-dose catecholamines (24%-28% reduction). Catecholamines 67-81 interleukin 4 Homo sapiens 25-29 16223057-7 2005 RESULTS: COMT Vall58Met is a common (minor allele frequency 0.42), functional, catecholamine-metabolizing enzyme polymorphism with threefold relevance. Catecholamines 79-92 catechol-O-methyltransferase Homo sapiens 9-13 16002552-1 2005 We have previously shown that prolactin-releasing peptide (PrRP) stimulates catecholamine release from PC12 cells (rat pheochromocytoma cell line). Catecholamines 76-89 prolactin releasing hormone Rattus norvegicus 59-63 16002552-3 2005 Thus, we examined the effect of PrRP on catecholamine biosynthesis in PC12 cells. Catecholamines 40-53 prolactin releasing hormone Rattus norvegicus 32-36 16002552-4 2005 PrRP31 (>10 nM) and PrRP20 (>100 nM) significantly increased the activity and expression level of tyrosine hydroxylase (TH), a rate-limiting enzyme, in catecholamine biosynthesis. Catecholamines 158-171 tyrosine hydroxylase Rattus norvegicus 104-124 16002552-4 2005 PrRP31 (>10 nM) and PrRP20 (>100 nM) significantly increased the activity and expression level of tyrosine hydroxylase (TH), a rate-limiting enzyme, in catecholamine biosynthesis. Catecholamines 158-171 tyrosine hydroxylase Rattus norvegicus 126-128 16002552-12 2005 These results indicate that PrRP stimulates catecholamine synthesis through both the PKC and PKA pathways in PC12 cells. Catecholamines 44-57 prolactin releasing hormone Rattus norvegicus 28-32 16002552-0 2005 Stimulation of catecholamine biosynthesis via the PKC pathway by prolactin-releasing peptide in PC12 rat pheochromocytoma cells. Catecholamines 15-28 prolactin releasing hormone Rattus norvegicus 65-92 16002552-1 2005 We have previously shown that prolactin-releasing peptide (PrRP) stimulates catecholamine release from PC12 cells (rat pheochromocytoma cell line). Catecholamines 76-89 prolactin releasing hormone Rattus norvegicus 30-57 15964536-0 2005 Cigarette smoking may reduce plasma leptin concentration via catecholamines. Catecholamines 61-75 leptin Homo sapiens 36-42 15964536-12 2005 Nicotine might indirectly reduce leptin secretion via enhanced plasma catecholamine concentration. Catecholamines 70-83 leptin Homo sapiens 33-39 15911134-7 2005 Urocortin (> or = 1 nM) significantly increased the mRNA level and activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in the biosynthesis of catecholamine. Catecholamines 155-168 urocortin Rattus norvegicus 0-9 15911134-7 2005 Urocortin (> or = 1 nM) significantly increased the mRNA level and activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in the biosynthesis of catecholamine. Catecholamines 155-168 tyrosine hydroxylase Rattus norvegicus 82-102 15911134-7 2005 Urocortin (> or = 1 nM) significantly increased the mRNA level and activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in the biosynthesis of catecholamine. Catecholamines 155-168 tyrosine hydroxylase Rattus norvegicus 104-106 15911134-10 2005 In conclusion, we have demonstrated that urocortin stimulates catecholamine biosynthesis via the cAMP/protein kinase A pathway in PC12 cells, where both urocortin and its receptor, CRF-R2, are expressed. Catecholamines 62-75 corticotropin releasing hormone receptor 2 Rattus norvegicus 181-187 16054084-0 2005 Renalase, a catecholamine-metabolizing hormone from the kidney. Catecholamines 12-25 renalase, FAD dependent amine oxidase Homo sapiens 0-8 15861457-6 2005 Compared with the regional assessment of gene expression, both CA1 and CA3 neurons displayed a relative enrichment of classes of transcripts that included glutamate receptors, transporters, and interacting proteins, GABA receptors and transporters, synaptic-related markers, and catecholamine receptors and transporters. Catecholamines 279-292 carbonic anhydrase 1 Homo sapiens 63-66 15861457-6 2005 Compared with the regional assessment of gene expression, both CA1 and CA3 neurons displayed a relative enrichment of classes of transcripts that included glutamate receptors, transporters, and interacting proteins, GABA receptors and transporters, synaptic-related markers, and catecholamine receptors and transporters. Catecholamines 279-292 carbonic anhydrase 3 Homo sapiens 71-74 15817484-3 2005 In the present study, we use catechol (1,2-benzenediol, a structural component of catecholamine agonists) as a molecular probe to identify mechanistic differences between beta(2)AR activation by catecholamine agonists, such as isoproterenol, and by the structurally related non-catechol partial agonist salbutamol. Catecholamines 195-208 adrenoceptor beta 2 Homo sapiens 171-180 16054084-2 2005 Renalase appears to be a hormone that metabolizes catecholamines, and its discovery will facilitate our understanding of sympathetic regulation. Catecholamines 50-64 renalase, FAD dependent amine oxidase Homo sapiens 0-8 15942127-1 2005 The role of nitric oxide (NO) in bradykinin (BK)-induced adrenal catecholamine secretion still remains obscure. Catecholamines 65-78 kininogen 1 Canis lupus familiaris 33-43 15862471-2 2005 Catechol-O-methyltransferase (COMT) is one of the enzymes that metabolize catecholamine neurotransmitters. Catecholamines 74-87 catechol-O-methyltransferase Homo sapiens 0-28 15862471-2 2005 Catechol-O-methyltransferase (COMT) is one of the enzymes that metabolize catecholamine neurotransmitters. Catecholamines 74-87 catechol-O-methyltransferase Homo sapiens 30-34 15894902-0 2005 Effect of the renin-angiotensin system or calcium channel blockade on the circadian variation of heart rate variability, blood pressure and circulating catecholamines in hypertensive patients. Catecholamines 152-166 renin Homo sapiens 14-19 15922273-2 2005 CaMKII activity is augmented by catecholamine stimulation, which enhances AV nodal conduction, suggesting the hypothesis that CaMKII also contributes to AV nodal conduction properties. Catecholamines 32-45 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 0-6 15922273-2 2005 CaMKII activity is augmented by catecholamine stimulation, which enhances AV nodal conduction, suggesting the hypothesis that CaMKII also contributes to AV nodal conduction properties. Catecholamines 32-45 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 126-132 15922273-11 2005 CONCLUSIONS: These studies define CaMKII as a critical determinant of normal and catecholamine-stimulated AV nodal conduction responses. Catecholamines 81-94 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 34-40 15889114-6 2005 CONCLUSION: Subjects born SGA demonstrated a hyperlipolytic reactivity to catecholamines, which might be regarded as an additional deleterious component of the insulin resistance associated with SGA. Catecholamines 74-88 insulin Homo sapiens 160-167 16231197-0 2005 Modelling the interaction of catecholamines with the alpha 1A adrenoceptor towards a ligand-induced receptor structure. Catecholamines 29-43 adrenoceptor alpha 1A Homo sapiens 53-74 16231197-3 2005 Analysis of agonist/alpha1A adrenoceptor complex interactions focused on the role of the charged amine group, the aromatic ring, the N-methyl group of adrenaline, the beta hydroxyl group and the catechol meta and para hydroxyl groups of the catecholamines. Catecholamines 241-255 adrenoceptor alpha 1A Homo sapiens 20-40 15942127-0 2005 Nitric oxide inhibits the bradykinin B2 receptor-mediated adrenomedullary catecholamine release but has no effect on adrenal blood flow response in vivo. Catecholamines 74-87 kininogen 1 Canis lupus familiaris 26-36 15942127-1 2005 The role of nitric oxide (NO) in bradykinin (BK)-induced adrenal catecholamine secretion still remains obscure. Catecholamines 65-78 kininogen 1 Canis lupus familiaris 45-47 15942127-2 2005 The present study was to investigate whether an inhibition of NO synthase with N(omega)-nitro-L-arginine methyl ester (L-NAME) would modulate BK-induced adrenal catecholamine secretion (ACS) and adrenal vasodilating response (AVR) in anesthetized dogs. Catecholamines 161-174 kininogen 1 Canis lupus familiaris 142-144 15583702-1 2005 The available data from preclinical and pharmacological studies on the role of the C-O-methyl transferase (COMT) support the hypothesis that abnormal catecholamine transmission has been implicated in the pathogenesis of mood disorders (MD). Catecholamines 150-163 catechol-O-methyltransferase Homo sapiens 83-105 15583702-1 2005 The available data from preclinical and pharmacological studies on the role of the C-O-methyl transferase (COMT) support the hypothesis that abnormal catecholamine transmission has been implicated in the pathogenesis of mood disorders (MD). Catecholamines 150-163 catechol-O-methyltransferase Homo sapiens 107-111 15696331-9 2005 CONCLUSIONS: A 62 g BCAA/TRP mixture decreases the availability of TYR and PHE for brain catecholamine synthesis and increases plasma prolactin consistent with lowered brain dopamine function. Catecholamines 89-102 AT-rich interaction domain 4B Homo sapiens 20-24 15833600-4 2005 Although the catecholamines, norepinephrine (NE) and dopamine (DA) are believed to be crucial factors in the stimulation of CRH neurons, it is not clear if they affect the cell bodies or terminals of these neurons to cause HPA activation. Catecholamines 13-27 corticotropin releasing hormone Rattus norvegicus 124-127 15823563-1 2005 Proadrenomedullin N-terminal 20 peptide (PAMP[1-20]/PAMP-20) and its truncated analog, PAMP[9-20]/PAMP-12, are endogenous peptides that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. Catecholamines 174-187 adrenomedullin Homo sapiens 41-45 15823563-1 2005 Proadrenomedullin N-terminal 20 peptide (PAMP[1-20]/PAMP-20) and its truncated analog, PAMP[9-20]/PAMP-12, are endogenous peptides that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. Catecholamines 174-187 adrenomedullin Homo sapiens 52-56 15823563-1 2005 Proadrenomedullin N-terminal 20 peptide (PAMP[1-20]/PAMP-20) and its truncated analog, PAMP[9-20]/PAMP-12, are endogenous peptides that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. Catecholamines 174-187 adrenomedullin Homo sapiens 52-56 15823563-1 2005 Proadrenomedullin N-terminal 20 peptide (PAMP[1-20]/PAMP-20) and its truncated analog, PAMP[9-20]/PAMP-12, are endogenous peptides that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. Catecholamines 174-187 adrenomedullin Homo sapiens 52-56 15823563-8 2005 From these results, we concluded that MrgX2 is a potential human PAMP-12 receptor that regulates catecholamine secretion from adrenal glands. Catecholamines 97-110 MAS related GPR family member X2 Homo sapiens 38-43 15823563-8 2005 From these results, we concluded that MrgX2 is a potential human PAMP-12 receptor that regulates catecholamine secretion from adrenal glands. Catecholamines 97-110 adrenomedullin Homo sapiens 65-69 15809070-6 2005 Tyrosine hydroxylase (TH), a rate-limiting enzyme for catecholamine synthesis, was also phosphorylated by Ucn 2. Catecholamines 54-67 tyrosine hydroxylase Rattus norvegicus 0-20 15904872-1 2005 Annexin A7 (synexin, annexin VII), a member of the annexin family of proteins, causes aggregation of membranes in a Ca2+-dependent manner and has been suggested to promote membrane fusion during exocytosis of lung surfactant, catecholamines, and insulin. Catecholamines 226-240 annexin A7 Rattus norvegicus 0-10 15809070-6 2005 Tyrosine hydroxylase (TH), a rate-limiting enzyme for catecholamine synthesis, was also phosphorylated by Ucn 2. Catecholamines 54-67 tyrosine hydroxylase Rattus norvegicus 22-24 15809070-6 2005 Tyrosine hydroxylase (TH), a rate-limiting enzyme for catecholamine synthesis, was also phosphorylated by Ucn 2. Catecholamines 54-67 urocortin 2 Rattus norvegicus 106-111 15809070-10 2005 These results suggest Ucn 2 in the adrenal gland may be involved in the regulation of catecholamine release and synthesis. Catecholamines 86-99 urocortin 2 Rattus norvegicus 22-27 15843612-1 2005 Hypoxia-inducible factor-1alpha (HIF-1alpha) plays an essential role in cellular and systemic O(2) homeostasis by regulating the expression of genes important in glycolysis, erythropoiesis, angiogenesis, and catecholamine metabolism. Catecholamines 208-221 hypoxia inducible factor 1, alpha subunit Mus musculus 0-31 16099306-2 2005 However, the expression of tyrosine hydroxylase (TH), the first enzyme in the catecholamine synthetic pathway, is only detected after E11/E12. Catecholamines 78-91 tyrosine hydroxylase Gallus gallus 27-47 15910801-5 2005 In the present study, bombesin and GRP elevated plasma catecholamines in a dose-dependent manner (1 and 5 nmol/animal, i.c.v. Catecholamines 55-69 gastrin releasing peptide Rattus norvegicus 35-38 15822093-5 2005 When DTRH uses tryptophan as a substrate, substrate inhibition, catecholamine inhibition, and decreased tryptophan hydroxylase activity in the presence of serotonin synthesis inhibitors are observed. Catecholamines 64-77 Tryptophan hydroxylase Drosophila melanogaster 5-9 15841207-5 2005 Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). Catecholamines 170-184 renalase, FAD dependent amine oxidase Homo sapiens 98-106 15841207-5 2005 Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). Catecholamines 170-184 renalase, FAD dependent amine oxidase Homo sapiens 195-203 15833366-0 2005 Interferon-gamma and interferon-beta affect endogenous catecholamines in human peripheral blood mononuclear cells: implications for multiple sclerosis. Catecholamines 55-69 interferon gamma Homo sapiens 0-16 15833366-0 2005 Interferon-gamma and interferon-beta affect endogenous catecholamines in human peripheral blood mononuclear cells: implications for multiple sclerosis. Catecholamines 55-69 interferon beta 1 Homo sapiens 21-36 15843612-1 2005 Hypoxia-inducible factor-1alpha (HIF-1alpha) plays an essential role in cellular and systemic O(2) homeostasis by regulating the expression of genes important in glycolysis, erythropoiesis, angiogenesis, and catecholamine metabolism. Catecholamines 208-221 hypoxia inducible factor 1, alpha subunit Mus musculus 33-43 15863947-6 2005 Along with increases in serum catecholamine and urine catecholamine metabolites, his serum interleukin (IL)-6 level was increased to 300 pg/ml, compared with a normal range of 3-12 pg/ml. Catecholamines 30-43 interleukin 6 Homo sapiens 91-109 15763132-1 2005 Pre-synaptic norepinephrine (NE) and dopamine (DA) transporters (NET and DAT) terminate catecholamine synaptic transmission through reuptake of released neurotransmitter. Catecholamines 88-101 solute carrier family 6 member 3 Homo sapiens 73-76 15763138-4 2005 Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent. Catecholamines 158-171 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 45-50 15763138-4 2005 Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent. Catecholamines 158-171 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 180-185 15763138-4 2005 Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent. Catecholamines 158-171 solute carrier family 6 member 3 Homo sapiens 79-82 15820695-0 2005 CAPS1 regulates catecholamine loading of large dense-core vesicles. Catecholamines 16-29 Ca2+-dependent secretion activator Mus musculus 0-5 15820695-5 2005 We conclude that CAPS1 is required for an essential step in the uptake or storage of catecholamines in LDCVs. Catecholamines 85-99 Ca2+-dependent secretion activator Mus musculus 17-22 15863947-6 2005 Along with increases in serum catecholamine and urine catecholamine metabolites, his serum interleukin (IL)-6 level was increased to 300 pg/ml, compared with a normal range of 3-12 pg/ml. Catecholamines 54-67 interleukin 6 Homo sapiens 91-109 15869485-3 2005 In this study on rats, we used combined anterograde neuronal tracing of CeA projections with confocal and electron microscopic immunohistochemical detection of phenylethanolamine-N-methyltransferase, the adrenaline-synthesizing enzyme present in C1 catecholamine neurones of the RVLM, and Fos, the protein product of the c-fos proto-oncogene. Catecholamines 249-262 phenylethanolamine-N-methyltransferase Rattus norvegicus 160-198 15809019-0 2005 Selective cerebral overexpression of growth hormone alters cardiac function, morphology, energy metabolism and catecholamines in transgenic mice. Catecholamines 111-125 growth hormone Mus musculus 37-51 15809019-15 2005 Decreased myocardial content of catecholamines in the GFAP-bGH mice suggests central interaction between GH and sympathetic nervous system. Catecholamines 32-46 glial fibrillary acidic protein Mus musculus 54-58 15809019-15 2005 Decreased myocardial content of catecholamines in the GFAP-bGH mice suggests central interaction between GH and sympathetic nervous system. Catecholamines 32-46 growth hormone Mus musculus 60-62 15766887-1 2005 Bovine adrenal chromaffin granule cytochrome (cyt) b561 is a transmembrane hemoprotein that plays a key role in transporting reducing equivalents from ascorbate to dopamine-beta-hydroxylase for catecholamine synthesis. Catecholamines 194-207 dopamine beta-hydroxylase Bos taurus 164-189 16028663-0 2005 Vasopressin infusion in children with catecholamine-resistant septic shock. Catecholamines 38-51 arginine vasopressin Homo sapiens 0-11 15694760-4 2005 Previous reports from our laboratory have described a 40-kDa catecholamine-regulated heat-shock-like protein (CRP40). Catecholamines 61-74 heat shock protein family A (Hsp70) member 9 Homo sapiens 110-115 16028663-1 2005 AIM: To describe use of vasopressin infusion for catecholamine-refractory septic shock in children. Catecholamines 49-62 arginine vasopressin Homo sapiens 24-35 16028663-5 2005 CONCLUSIONS: Vasopressin appears to be useful in treatment of catecholamine-refractory septic shock in children. Catecholamines 62-75 arginine vasopressin Homo sapiens 13-24 15618033-2 2005 This study assessed the relationship between catecholamines and active MMPs in vivo in patients with severe congestive heart failure (CHF) and in vitro in human cardiac fibroblasts. Catecholamines 45-59 matrix metallopeptidase 2 Homo sapiens 71-75 15605286-4 2005 In this case report, we present two cases with temporarily successful cardiopulmonary resuscitation (CPR) using vasopressin and catecholamines in uncontrolled hemorrhagic shock with subsequent cardiac arrest that was refractory to catecholamines and fluid replacement. Catecholamines 231-245 arginine vasopressin Homo sapiens 112-123 15618033-8 2005 Moreover, this catecholamine increased MMP-2 in human cardiac fibroblasts. Catecholamines 15-28 matrix metallopeptidase 2 Homo sapiens 39-44 15618033-9 2005 CONCLUSIONS: The positive correlation between noradrenaline and MMP-2 in severe CHF patients, together with the in vitro induction of MMP-2 by this catecholamine, suggests a potential biochemical link between noradrenaline and MMP-2. Catecholamines 148-161 matrix metallopeptidase 2 Homo sapiens 134-139 15618033-9 2005 CONCLUSIONS: The positive correlation between noradrenaline and MMP-2 in severe CHF patients, together with the in vitro induction of MMP-2 by this catecholamine, suggests a potential biochemical link between noradrenaline and MMP-2. Catecholamines 148-161 matrix metallopeptidase 2 Homo sapiens 134-139 15635098-2 2005 In chromaffin cells, we previously reported that catecholamine secretion requires the translocation and formation of the annexin 2 tetramer near the exocytotic sites. Catecholamines 49-62 annexin A2 Homo sapiens 121-130 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 0-28 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. Catecholamines 122-136 catechol-O-methyltransferase Homo sapiens 30-34 15710461-4 2005 These findings demonstrate that adrenergic receptor antagonists unmask autocrine actions of macrophage-derived catecholamines on IL-1(beta) that may influence the inflammatory response. Catecholamines 111-125 interleukin 1 beta Mus musculus 129-139 15790329-9 2005 Therefore, we concluded that the tachycardia was due to the cholinesterase inhibitor substance, causing catecholamine release by stimulation of nicotinic receptors. Catecholamines 104-117 butyrylcholinesterase Homo sapiens 60-74 15598970-6 2005 After salt loading, alpha1B-AR knockout mice developed a comparable level of hypertension to wild-type mice, whereas mice lacking alpha1D-AR had significantly (p < 0.05) attenuated BP and lower levels of circulating catecholamines. Catecholamines 219-233 adrenergic receptor, alpha 1d Mus musculus 130-140 15710461-0 2005 Autocrine actions of macrophage-derived catecholamines on interleukin-1 beta. Catecholamines 40-54 interleukin 1 beta Mus musculus 58-76 15736119-10 2005 By showing a dose-dependent increasing influence of insulin on systolic BP and circulating catecholamine levels, the present study provides experimental evidence for the notion that hyperinsulinemia contributes to the development of hypertension. Catecholamines 91-104 insulin Homo sapiens 52-59 15713533-5 2005 Deletion studies of cells stably transfected with truncated hMR indicated that the N-terminal and the DNA binding domains of hMR are essential for enhancement of the catecholamine signal transduction pathway. Catecholamines 166-179 nuclear receptor subfamily 4 group A member 1 Homo sapiens 60-63 15713533-5 2005 Deletion studies of cells stably transfected with truncated hMR indicated that the N-terminal and the DNA binding domains of hMR are essential for enhancement of the catecholamine signal transduction pathway. Catecholamines 166-179 nuclear receptor subfamily 4 group A member 1 Homo sapiens 125-128 15710233-1 2005 Activity and expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine synthesis, are modified in response to antidepressant-treatment. Catecholamines 83-96 tyrosine hydroxylase Rattus norvegicus 27-47 15710233-1 2005 Activity and expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine synthesis, are modified in response to antidepressant-treatment. Catecholamines 83-96 tyrosine hydroxylase Rattus norvegicus 49-51 15642619-9 2005 We hypothesize that ERbeta is required during development to modulate the effects of estrogen on anxiety and catecholamine concentrations in female mouse brains. Catecholamines 109-122 estrogen receptor 2 (beta) Mus musculus 20-26 15494206-1 2005 The cardiac actions of catecholamines have long been attributed to the predominant beta(1)-AR subtype that couples to the classical Gs/AC/cAMP pathway. Catecholamines 23-37 adrenoceptor beta 1 Homo sapiens 83-93 15652410-0 2005 Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1 beta independent of a catecholamine-driven increase in IL-10 production. Catecholamines 92-105 interleukin 10 Rattus norvegicus 125-130 15655528-2 2005 Where known, the mode of action in cardiovascular disease is from antagonism of endogenous catecholamine responses in the heart (mainly at beta1-adrenoceptors), while the worrisome side effects of bronchospasm result from airway beta2-adrenoceptor blockade. Catecholamines 91-104 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 139-144 15723172-1 2005 Catestatin (bCGA(344-364)), an endogenous peptide of bovine chromogranin A, was initially characterized for its effect on the inhibition of catecholamine release from chromaffin cells. Catecholamines 140-153 chromogranin A Homo sapiens 0-10 15383007-1 2005 ANG II (angiotensin II) facilitates catecholamine release from the adrenal medulla and neuronal NE (noradrenaline) release. Catecholamines 36-49 angiotensinogen Homo sapiens 8-22 15787695-1 2005 The regulation of gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, was studied in brainstem noradrenergic nuclei, locus coeruleus (LC), A2 and A1, in vitro. Catecholamines 92-105 tyrosine hydroxylase Homo sapiens 37-57 15787695-1 2005 The regulation of gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, was studied in brainstem noradrenergic nuclei, locus coeruleus (LC), A2 and A1, in vitro. Catecholamines 92-105 tyrosine hydroxylase Homo sapiens 59-61 15883710-6 2005 As routine diagnostic procedure all SDH mutation carriers should have urine catecholamine analysis as well as pelvic, abdominal, thoracic and skull/neck MRI. Catecholamines 76-89 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 36-39 21166164-7 2005 CONCLUSION: Endogenous catecholamine mediates the arrhythmogenic, positively chronotropic and inotropic effects of IL-2. Catecholamines 23-36 interleukin 2 Rattus norvegicus 115-119 15673663-1 2005 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 0-28 15673663-1 2005 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamines 49-62 catechol-O-methyltransferase Homo sapiens 30-34 15627480-10 2005 Our observations indicate that drugs, which stimulate or block adrenoceptors and catecholamine release may lead to complications in drug therapy and modulate the toxicity or carcinogenicity of drugs that are substrates for the CYP1A1. Catecholamines 81-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 227-233 16594133-4 2005 Insulin-induced increase in resting muscle VO2 was abrogated by catecholamines. Catecholamines 64-78 insulin Canis lupus familiaris 0-7 15388645-1 2005 Insulin counterregulates catecholamine action in part by inducing the sequestration of beta2-adrenergic receptors. Catecholamines 25-38 insulin Homo sapiens 0-7 15388649-5 2005 Prolactin stimulated a time- and concentration-dependent increase in catecholamine synthesis, which was maximal after 60-120 min (1 microg/ml prolactin) and inhibited by the prolactin antagonist Delta1-9-G129R-hPRL. Catecholamines 69-82 prolactin Homo sapiens 210-214 15388649-6 2005 This prolactin response was accompanied by a rise in the site-specific (ser-19, -31, and -40) phosphorylation of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 168-181 tyrosine hydroxylase Rattus norvegicus 113-133 15388649-6 2005 This prolactin response was accompanied by a rise in the site-specific (ser-19, -31, and -40) phosphorylation of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 168-181 tyrosine hydroxylase Rattus norvegicus 135-137 21166164-0 2005 [Endogenous catecholamine participates in the action of interleukin-2 on the isolated rat heart]. Catecholamines 12-25 interleukin 2 Rattus norvegicus 56-69 21166164-1 2005 AIM: To explore whether endogenous catecholamine participates in the effect of interleukin-2 on the isolated heart. Catecholamines 35-48 interleukin 2 Rattus norvegicus 79-92 15634779-0 2005 Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons. Catecholamines 34-48 hypocretin Mus musculus 52-62 15634779-12 2005 These data suggest that catecholamines evoke strong inhibitory actions on hypocretin neurons and suggest negative feedback from catecholamine cells that may be excited by hypocretin. Catecholamines 24-38 hypocretin Mus musculus 74-84 15634779-12 2005 These data suggest that catecholamines evoke strong inhibitory actions on hypocretin neurons and suggest negative feedback from catecholamine cells that may be excited by hypocretin. Catecholamines 24-37 hypocretin Mus musculus 74-84 15621046-1 2005 OBJECTIVE: Increased expression of the transcription factor early growth response gene-1 (Egr-1) accompanies catecholamine infusion. Catecholamines 109-122 early growth response 1 Mus musculus 60-88 15621046-1 2005 OBJECTIVE: Increased expression of the transcription factor early growth response gene-1 (Egr-1) accompanies catecholamine infusion. Catecholamines 109-122 early growth response 1 Mus musculus 90-95 15621046-2 2005 Catecholamine-treated, Egr-1-deficient (-/-) mice show exacerbated cardiac damage when compared to similarly treated wild-type (+/+) mice, suggesting that Egr-1 reduces heart damage. Catecholamines 0-13 early growth response 1 Mus musculus 23-28 15621046-2 2005 Catecholamine-treated, Egr-1-deficient (-/-) mice show exacerbated cardiac damage when compared to similarly treated wild-type (+/+) mice, suggesting that Egr-1 reduces heart damage. Catecholamines 0-13 early growth response 1 Mus musculus 155-160 15621046-4 2005 METHODS: Microarray analyses identified increased sodium calcium exchanger-1 (NCX1) expression in catecholamine-treated -/- mice. Catecholamines 98-111 solute carrier family 8 (sodium/calcium exchanger), member 1 Mus musculus 78-82 15621046-7 2005 RESULTS: Immunoblots revealed a two- to threefold increase in NCX1 in catecholamine-stimulated and naive -/- versus +/+ mice. Catecholamines 70-83 solute carrier family 8 (sodium/calcium exchanger), member 1 Mus musculus 62-66 15875138-2 2005 VP was infused in two posthemorrhagic vasodilatory shock patients when they remained persistently hypotensive despite adequate fluid resuscitation and infusions of pharmacological doses of catecholamines. Catecholamines 189-203 arginine vasopressin Homo sapiens 0-2 16076033-14 2005 Nevertheless, the impact of catecholamines on IL-8 synthesis and expression of CD15, CD44, and CD54 is limited. Catecholamines 28-42 C-X-C motif chemokine ligand 8 Homo sapiens 46-50 15583821-6 2005 Findings indicate that NPY is co-released with catecholamines under a variety of stimuli, including splanchnic nerve and cholinergic- and nicotinic-receptor activation. Catecholamines 47-61 neuropeptide Y Rattus norvegicus 23-26 15583821-7 2005 NPY, mainly acting via the Y1-R, Y2-R and Y3-R, either inhibits catecholamine secretion from bovine adrenal chromaffin cells or stimulates catecholamine secretion from adrenomedullary cells of humans and rats. Catecholamines 64-77 neuropeptide Y Bos taurus 0-3 15583821-7 2005 NPY, mainly acting via the Y1-R, Y2-R and Y3-R, either inhibits catecholamine secretion from bovine adrenal chromaffin cells or stimulates catecholamine secretion from adrenomedullary cells of humans and rats. Catecholamines 139-152 neuropeptide Y Bos taurus 0-3 15583821-10 2005 However, there is indication that the main effect of NPY on the ZG in rats is indirect and involves the local release of catecholamines, which in turn, acting via beta-adrenoceptors, enhance the secretion of aldosterone. Catecholamines 121-135 neuropeptide Y Rattus norvegicus 53-56 15231500-0 2004 Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling. Catecholamines 96-110 dopamine beta hydroxylase Mus musculus 17-42 15613065-0 2005 AT-1 receptor antagonism modifies the mediation of endothelin-1, thromboxane A2, and catecholamines in the renal constrictor response to angiotensin II. Catecholamines 85-99 angiotensinogen Rattus norvegicus 137-151 15613065-10 2005 CONCLUSION: The study further supports the importance of catecholamines, TXA(2), and ET-1 as mediators of the renal vasoconstriction induced by Ang II in both normotensive and hypertensive rats. Catecholamines 57-71 angiotensinogen Rattus norvegicus 144-150 16399348-4 2005 SULT1A3 is the major catecholamine sulfonating form, which is consistent with it being expressed principally in the gastrointestinal tract. Catecholamines 21-34 sulfotransferase family 1A member 3 Homo sapiens 0-7 16222039-2 2005 Catecholamine-dependent mechanisms can markedly upregulate alveolar fluid clearance even under pathological conditions, an effect that is mediated by both epithelial sodium channel (ENaC) and cystic fibrosis transmembrane conductance regulator (CFTR). Catecholamines 0-13 CF transmembrane conductance regulator Homo sapiens 192-243 16222039-2 2005 Catecholamine-dependent mechanisms can markedly upregulate alveolar fluid clearance even under pathological conditions, an effect that is mediated by both epithelial sodium channel (ENaC) and cystic fibrosis transmembrane conductance regulator (CFTR). Catecholamines 0-13 CF transmembrane conductance regulator Homo sapiens 245-249 15783246-9 2005 Long-term medical treatments with propranolol and the gonadotropin-releasing hormone analog leuprorelin (leuprolide acetate) were effective in patients with catecholamine-dependent and LH-dependent Cushing syndrome, respectively. Catecholamines 157-170 gonadotropin releasing hormone 1 Homo sapiens 54-84 15690966-9 2004 COMT is one of the two enzymes degrading catecholamines such as dopamine. Catecholamines 41-55 catechol-O-methyltransferase Homo sapiens 0-4 15613245-1 2004 BACKGROUND: An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Catecholamines 124-137 catechol-O-methyltransferase Homo sapiens 57-85 15613245-1 2004 BACKGROUND: An association has been observed between the catechol-O-methyltransferase (COMT) gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC), and neuropsychological task performance in healthy and schizophrenic adults. Catecholamines 124-137 catechol-O-methyltransferase Homo sapiens 87-91 15588731-3 2004 We studied the alterations in tyrosine hydroxylase (the rate-limiting enzyme in catecholamines biosynthesis) and tyrosine hydroxylase activity in the heart (right and left ventricle) during morphine withdrawal. Catecholamines 80-94 tyrosine hydroxylase Rattus norvegicus 30-50 15817751-0 2004 Catecholamines and aggression: the role of COMT and MAO polymorphisms. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 43-47 15817751-3 2004 Two major enzymes are responsible for catecholamine catabolism in the brain: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA). Catecholamines 38-51 catechol-O-methyltransferase Homo sapiens 77-105 15817751-3 2004 Two major enzymes are responsible for catecholamine catabolism in the brain: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA). Catecholamines 38-51 catechol-O-methyltransferase Homo sapiens 107-111 15817751-3 2004 Two major enzymes are responsible for catecholamine catabolism in the brain: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA). Catecholamines 38-51 monoamine oxidase A Homo sapiens 117-136 15817751-3 2004 Two major enzymes are responsible for catecholamine catabolism in the brain: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA). Catecholamines 38-51 monoamine oxidase A Homo sapiens 138-142 15817751-5 2004 If aggressive behavior is enhanced by catecholaminergic activity, then the lower activity of COMT and MAOA (resulting in a slower inactivation of catecholamines) should indirectly enhance aggression. Catecholamines 146-160 catechol-O-methyltransferase Homo sapiens 93-97 15817751-5 2004 If aggressive behavior is enhanced by catecholaminergic activity, then the lower activity of COMT and MAOA (resulting in a slower inactivation of catecholamines) should indirectly enhance aggression. Catecholamines 146-160 monoamine oxidase A Homo sapiens 102-106 15561906-0 2004 Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. Catecholamines 99-112 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 22-28 15561906-3 2004 Here, upon catecholamine challenge, disruption of KATP channels, by genetic deletion of the pore-forming Kir6.2 subunit, produced defective cardiac action potential shortening, predisposing the myocardium to early afterdepolarizations. Catecholamines 11-24 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 105-111 15591027-5 2004 Basal and catecholamine-induced UCP1 expression were not affected by PRL. Catecholamines 10-23 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 32-36 15556832-9 2004 These COMT metabolites may also help in elucidation of still undiscovered genetic and acquired disorders of catecholamine metabolism. Catecholamines 108-121 catechol-O-methyltransferase Homo sapiens 6-10 15367723-0 2004 Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins. Catecholamines 112-126 tyrosine hydroxylase Homo sapiens 76-96 15367723-1 2004 Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, has a common tetranucleotide repeat polymorphism, (TCAT)(n). Catecholamines 50-63 tyrosine hydroxylase Homo sapiens 0-20 15486316-0 2004 Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Catecholamines 61-74 epidermal growth factor receptor Rattus norvegicus 19-51 15607574-3 2005 Physiological concentrations of insulin as well as of catecholamines have been shown to boost adipocyte production of IL-6 dose-dependently. Catecholamines 54-68 interleukin 6 Homo sapiens 118-122 16210867-1 2005 Previous studies indicated that in the human paraventricular nucleus (PVN) and in the supraoptic nucleus (SON) tyrosine hydroxylase (TH) - the first and rate-limiting enzyme in catecholamine synthesis - is localized mainly in magnocellular neurosecretory neurons. Catecholamines 177-190 tyrosine hydroxylase Homo sapiens 111-131 16210867-1 2005 Previous studies indicated that in the human paraventricular nucleus (PVN) and in the supraoptic nucleus (SON) tyrosine hydroxylase (TH) - the first and rate-limiting enzyme in catecholamine synthesis - is localized mainly in magnocellular neurosecretory neurons. Catecholamines 177-190 tyrosine hydroxylase Homo sapiens 133-135 15590154-0 2005 Angiotensin II AT-1A receptor immunolabeling in rat medial nucleus tractus solitarius neurons: subcellular targeting and relationships with catecholamines. Catecholamines 140-154 angiotensinogen Rattus norvegicus 0-14 15590154-11 2005 These results suggest that AT-1A receptors are positioned for modulation of catecholamine signaling in the mNTS. Catecholamines 76-89 angiotensin II receptor, type 1a Rattus norvegicus 27-32 15471880-1 2004 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its activity is regulated by phosphorylation in the N-terminal regulatory domain. Catecholamines 57-70 tyrosine hydroxylase Mus musculus 0-20 15471880-1 2004 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its activity is regulated by phosphorylation in the N-terminal regulatory domain. Catecholamines 57-70 tyrosine hydroxylase Mus musculus 22-24 15518890-0 2004 Expression of mRNAs for PACAP and its receptor in human neuroblastomas and their relationship to catecholamine synthesis. Catecholamines 97-110 adenylate cyclase activating polypeptide 1 Homo sapiens 24-29 15518890-1 2004 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 167-180 adenylate cyclase activating polypeptide 1 Homo sapiens 9-59 15518890-1 2004 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 167-180 adenylate cyclase activating polypeptide 1 Homo sapiens 61-66 15518890-2 2004 In addition, PACAP and its receptor have been detected in human neuroblastoma tissues and cell lines, though it is not yet known whether PACAP enhances the expression of genes encoding catecholamine-synthesizing enzymes. Catecholamines 185-198 adenylate cyclase activating polypeptide 1 Homo sapiens 137-142 15448133-1 2004 GTP cyclohydrolase I (GTPCHI) is the rate-limiting enzyme involved in the biosynthesis of tetrahydrobiopterin, a key cofactor necessary for nitric oxide synthase and for the hydroxylases that are involved in the production of catecholamines and serotonin. Catecholamines 226-240 GTP cyclohydrolase 1 Homo sapiens 0-20 15448133-1 2004 GTP cyclohydrolase I (GTPCHI) is the rate-limiting enzyme involved in the biosynthesis of tetrahydrobiopterin, a key cofactor necessary for nitric oxide synthase and for the hydroxylases that are involved in the production of catecholamines and serotonin. Catecholamines 226-240 GTP cyclohydrolase 1 Homo sapiens 22-28 15528398-6 2004 Hindbrain neurons producing neuropeptide Y (NPY) and catecholamines (CA) then project to the forebrain where they contact GnRH neurons both directly and also indirectly via corticotropin-releasing hormone (CRH) neurons to inhibit GnRH secretion. Catecholamines 53-67 gonadotropin releasing hormone 1 Homo sapiens 122-126 15677399-0 2004 Stressor specificity and effect of prior experience on catecholamine biosynthetic enzyme phenylethanolamine N-methyltransferase. Catecholamines 55-68 phenylethanolamine-N-methyltransferase Rattus norvegicus 89-127 15677399-2 2004 The aim of this work was to investigate changes in catecholamine (CA) biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT) gene expression, protein level, and activity in the adrenal medulla of rats after a single or repeated exposure to various homotypic or novel heterotypic stressors. Catecholamines 51-64 phenylethanolamine-N-methyltransferase Rattus norvegicus 90-128 15677399-2 2004 The aim of this work was to investigate changes in catecholamine (CA) biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT) gene expression, protein level, and activity in the adrenal medulla of rats after a single or repeated exposure to various homotypic or novel heterotypic stressors. Catecholamines 51-64 phenylethanolamine-N-methyltransferase Rattus norvegicus 130-134 15385622-4 2004 We found that catecholamines (l-3,4-hydroxyphenylalanine [l-dopa], dopamine, adrenaline, and noradrenaline) elevate FUS1 and RLM1 transcription. Catecholamines 14-28 Fus1p Saccharomyces cerevisiae S288C 116-120 15385622-4 2004 We found that catecholamines (l-3,4-hydroxyphenylalanine [l-dopa], dopamine, adrenaline, and noradrenaline) elevate FUS1 and RLM1 transcription. Catecholamines 14-28 Rlm1p Saccharomyces cerevisiae S288C 125-129 15385622-5 2004 N-Acetyl-cysteine, a powerful antioxidant in yeast, completely reversed this effect, suggesting that FUS1 and RLM1 activation in response to catecholamines is a result of oxidative stress. Catecholamines 141-155 Fus1p Saccharomyces cerevisiae S288C 101-105 15385622-5 2004 N-Acetyl-cysteine, a powerful antioxidant in yeast, completely reversed this effect, suggesting that FUS1 and RLM1 activation in response to catecholamines is a result of oxidative stress. Catecholamines 141-155 Rlm1p Saccharomyces cerevisiae S288C 110-114 15518636-5 2004 Central Ang II administration to vehicle-treated SHRs further increased blood pressure, provoked drinking, increased tyrosine hydroxylase (TH) mRNA expression in the locus coeruleus, and stimulated sympathoadrenal catecholamine release. Catecholamines 214-227 angiotensinogen Rattus norvegicus 8-14 15518636-6 2004 Pretreatment with the AT(1) receptor antagonist eliminated Ang II-induced increases in blood pressure, water intake, and sympathoadrenal catecholamine release; inhibited peripheral and brain AT(1) receptors; increased AT(2) receptor binding in the locus coeruleus, inferior olive, and adrenal cortex; and decreased AT(2) receptor binding in the adrenal medulla. Catecholamines 137-150 angiotensinogen Rattus norvegicus 59-65 15231500-9 2004 These studies suggest that the trophic effects of catecholamines are mediated primarily by alpha1B-ARs in mouse carotid and contribute to hypertrophic growth after vascular injury. Catecholamines 50-64 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 91-98 15492314-8 2004 CONCLUSIONS: Moderate overexpression of NOS3, targeted to caveolae in murine cardiomyocytes, potentiates the postsynaptic muscarinic response and attenuates the effect of high concentrations of catecholamines. Catecholamines 194-208 nitric oxide synthase 3, endothelial cell Mus musculus 40-44 15549173-2 2004 Whereas there is evidence that Ang II may potentiate the effects of catecholamines, various cytokines and also growth factors, the repertoire of substances which may inhibit the actions of Ang II is more limited and has been restricted primarily to prostacyclin, bradykinin and nitric oxide. Catecholamines 68-82 angiotensinogen Homo sapiens 31-37 15666839-8 2004 On the ultrastructural level, adrenal chromaffin cells in SVCT2 null mice show depletion of catecholamine storage vesicles, signs of apoptosis, and increased glycogen storage. Catecholamines 92-105 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 58-63 15531530-4 2004 The majority (>70%) of hereditary extraadrenal PCs [catecholamine-secreting paragangliomas (PGL)] are accounted for by germline intragenic mutations in SDHB, SDHC, or SDHD. Catecholamines 52-65 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 152-156 15531530-4 2004 The majority (>70%) of hereditary extraadrenal PCs [catecholamine-secreting paragangliomas (PGL)] are accounted for by germline intragenic mutations in SDHB, SDHC, or SDHD. Catecholamines 52-65 succinate dehydrogenase complex subunit D Homo sapiens 167-171 15496512-1 2004 GTP cyclohydrolase I (GCH) is the rate-controlling enzyme in the production of tetrahydrobiopterin (BH4) that is essential for the synthesis of nitric oxide and catecholamines including dopamine and serotonin. Catecholamines 161-175 GTP cyclohydrolase 1 Homo sapiens 0-20 15496512-1 2004 GTP cyclohydrolase I (GCH) is the rate-controlling enzyme in the production of tetrahydrobiopterin (BH4) that is essential for the synthesis of nitric oxide and catecholamines including dopamine and serotonin. Catecholamines 161-175 GTP cyclohydrolase 1 Homo sapiens 22-25 15496512-2 2004 Therefore, the regulation of GCH expression is important in determining the catecholamine levels in the brain under pathophysiological conditions. Catecholamines 76-89 GTP cyclohydrolase 1 Homo sapiens 29-32 15564877-0 2004 The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines. Catecholamines 86-100 adrenoceptor beta 1 Homo sapiens 14-32 15564877-11 2004 CONCLUSION: These data indicate that the Arg389Gly beta1AR polymorphism is functionally relevant in vivo and determines contractile responsiveness to catecholamines in humans. Catecholamines 150-164 adrenoceptor beta 1 Homo sapiens 51-58 15356668-7 2004 Studies in human adipocytes indicate that PAI-1 synthesis is upregulated by insulin, glucocorticoids, angiotensin II, some fatty acids and, most potently, by cytokines such as tumour necrosis factor-alpha and transforming growth factor-beta, whereas catecholamines reduce PAI-1 production. Catecholamines 250-264 serpin family E member 1 Homo sapiens 42-47 15838288-14 2004 catecholamines exert significant hemodynamic effects and modulate ET-1 and adenosine release from the heart. Catecholamines 0-14 endothelin 1 Canis lupus familiaris 66-70 15326220-1 2004 The catestatin fragment of chromogranin A is an endogenous inhibitor of nicotinic cholinergic transmission, functioning in negative feedback control of catecholamine secretion. Catecholamines 152-165 chromogranin A Homo sapiens 4-14 15326220-1 2004 The catestatin fragment of chromogranin A is an endogenous inhibitor of nicotinic cholinergic transmission, functioning in negative feedback control of catecholamine secretion. Catecholamines 152-165 chromogranin A Homo sapiens 27-41 15451190-14 2004 Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine synthesis. Catecholamines 52-65 tyrosine hydroxylase Homo sapiens 0-20 15369781-0 2004 Pleiotrophin is a major regulator of the catecholamine biosynthesis pathway in mouse aorta. Catecholamines 41-54 pleiotrophin Mus musculus 0-12 15464265-2 2004 Here we tested the hypothesis that Sry regulates transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 141-155 sex determining region Y Rattus norvegicus 35-38 15464265-8 2004 These results reveal that Sry can regulate TH transcription and suggest that this may be one of the mechanisms of Sry mediated regulation of catecholamine biosynthesis in catecholaminergic neurons in males. Catecholamines 141-154 sex determining region Y Rattus norvegicus 26-29 15464265-8 2004 These results reveal that Sry can regulate TH transcription and suggest that this may be one of the mechanisms of Sry mediated regulation of catecholamine biosynthesis in catecholaminergic neurons in males. Catecholamines 141-154 sex determining region Y Rattus norvegicus 114-117 15369781-4 2004 These findings suggest that Ptn gene expression has a critical role in determining the levels of expression of the enzymes of catecholamine biosynthesis in aorta and through this mechanism, PTN may regulate levels of endogenous catecholamine synthesis and potentially the vascular tone of aorta. Catecholamines 126-139 pleiotrophin Mus musculus 28-31 15369781-4 2004 These findings suggest that Ptn gene expression has a critical role in determining the levels of expression of the enzymes of catecholamine biosynthesis in aorta and through this mechanism, PTN may regulate levels of endogenous catecholamine synthesis and potentially the vascular tone of aorta. Catecholamines 126-139 pleiotrophin Mus musculus 190-193 15369781-4 2004 These findings suggest that Ptn gene expression has a critical role in determining the levels of expression of the enzymes of catecholamine biosynthesis in aorta and through this mechanism, PTN may regulate levels of endogenous catecholamine synthesis and potentially the vascular tone of aorta. Catecholamines 228-241 pleiotrophin Mus musculus 28-31 15369781-4 2004 These findings suggest that Ptn gene expression has a critical role in determining the levels of expression of the enzymes of catecholamine biosynthesis in aorta and through this mechanism, PTN may regulate levels of endogenous catecholamine synthesis and potentially the vascular tone of aorta. Catecholamines 228-241 pleiotrophin Mus musculus 190-193 15378513-3 2004 We examined the effects of lesions of mPFC catecholamine terminals on local expression of Fos after exposure to air puff, a stimulus that in the rat acts as an acute psychological stressor. Catecholamines 43-56 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 90-93 15226157-9 2004 We conclude that 1) catecholamines stimulate cAMP-dependent anion and fluid secretion by IMCDi cells primarily through beta2-AR activation and 2) alpha2-AR activation attenuates cAMP-dependent anion secretion. Catecholamines 20-34 adrenoceptor beta 2 Homo sapiens 119-127 15456539-0 2004 Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro. Catecholamines 10-24 interleukin 2 Rattus norvegicus 28-32 15452869-2 2004 Tyrosine hydroxylase (TH) is the first, rate-limiting enzyme in catecholamine synthesis. Catecholamines 64-77 tyrosine hydroxylase Mus musculus 0-20 15448539-0 2004 Vasopressin for hemodynamic rescue in catecholamine-resistant vasoplegic shock after resection of massive pheochromocytoma. Catecholamines 38-51 arginine vasopressin Homo sapiens 0-11 15451151-2 2004 METHODS AND RESULTS: Myocardial catecholamine storage capacity was determined in 12 non-rejecting transplant recipients using PET and C-11 adrenaline (epinephrine). Catecholamines 32-45 aldo-keto reductase family 1 member C4 Homo sapiens 134-138 15488059-1 2004 Vasopressin and its analogue, terlipressin, are potent vasopressors that may be useful therapeutic agents in the treatment of cardiac arrest, septic and catecholamine-resistant shock and oesophageal variceal haemorrhage. Catecholamines 153-166 arginine vasopressin Homo sapiens 0-11 15488059-5 2004 Low doses of vasopressin and terlipressin can restore vasomotor tone in conditions that are resistant to catecholamines, with preservation of renal blood flow and urine output. Catecholamines 105-119 arginine vasopressin Homo sapiens 13-24 15452869-2 2004 Tyrosine hydroxylase (TH) is the first, rate-limiting enzyme in catecholamine synthesis. Catecholamines 64-77 tyrosine hydroxylase Mus musculus 22-24 15363956-5 2004 In the present study, therefore, we attempted to identify which pathway is involved in the vasopressin-induced release of both catecholamines from adrenal medulla using urethane-anesthetized rats. Catecholamines 127-141 arginine vasopressin Rattus norvegicus 91-102 15480914-6 2004 When DTPH uses phenylalanine as a substrate, regulatory control (end product inhibition, decreased PAH activity following phosphorylation, catecholamine inhibition) is observed that is not seen when the enzyme uses tryptophan as a substrate. Catecholamines 139-152 Henna Drosophila melanogaster 5-9 15447682-6 2004 Moreover, the sensor cells have not only vesicular monoamine transporter 1 (VMAT1) transporting catecholamines but also VMAT2, which is highly specific for histamine. Catecholamines 96-110 solute carrier family 18 member A1 Rattus norvegicus 41-74 15447682-6 2004 Moreover, the sensor cells have not only vesicular monoamine transporter 1 (VMAT1) transporting catecholamines but also VMAT2, which is highly specific for histamine. Catecholamines 96-110 solute carrier family 18 member A1 Rattus norvegicus 76-81 15124004-1 2004 The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 99-113 catechol-O-methyltransferase Homo sapiens 11-39 15124004-1 2004 The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine. Catecholamines 99-113 catechol-O-methyltransferase Homo sapiens 41-45 15258146-4 2004 EPAS1, also referred to as hypoxia-inducible factor 2alpha, is a transcription factor known to play essential roles in catecholamine homeostasis, vascular remodeling, and the maintenance of reactive oxygen species, and so forth. Catecholamines 119-132 endothelial PAS domain protein 1 Mus musculus 0-5 15258146-4 2004 EPAS1, also referred to as hypoxia-inducible factor 2alpha, is a transcription factor known to play essential roles in catecholamine homeostasis, vascular remodeling, and the maintenance of reactive oxygen species, and so forth. Catecholamines 119-132 endothelial PAS domain protein 1 Mus musculus 27-58 15273248-6 2004 Cdk5 inhibition also increases the total charge and current of catecholamine released during the amperometric foot, representing a modification of the conductance of the initial fusion pore connecting the granule and plasma membrane. Catecholamines 63-76 cyclin dependent kinase 5 Homo sapiens 0-4 15358107-1 2004 Sulfotransferase (SULT) 1A3 catalyzes the sulfate conjugation of catecholamines. Catecholamines 65-79 sulfotransferase family 1A member 3 Homo sapiens 0-27 15337696-8 2004 Plasma catecholamines in NET(-/-) and NET(+/+) mice were as follows: NE, 69+/-8 and 32+/-7; dihydroxyphenylglycol, 2+0.4 and 17+/-3; epinephrine, 15+/-3 and 4+/-0.6; and dopamine, 13+/-4 and 4+/-1 pmol/mL. Catecholamines 7-21 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 25-28 15315626-1 2004 Terlipressin--a long-acting analogue of vasopressin--has been described to restore blood pressure in patients with catecholamine-resistant septic shock without obvious complications. Catecholamines 115-128 arginine vasopressin Homo sapiens 40-51 15621715-3 2004 Cu(2+)-mediated inactivation of PON1 was enhanced remarkably by catecholamines, but not by uric acid or homocysteine. Catecholamines 64-78 paraoxonase 1 Homo sapiens 32-36 15322424-2 2004 DDC, like tyrosine hydroxylase (TH), is an enzyme involved in the catecholamine synthesis pathway and has recently been proposed as a specific marker of NB among pediatric malignancies. Catecholamines 66-79 dopa decarboxylase Homo sapiens 0-3 15322424-2 2004 DDC, like tyrosine hydroxylase (TH), is an enzyme involved in the catecholamine synthesis pathway and has recently been proposed as a specific marker of NB among pediatric malignancies. Catecholamines 66-79 tyrosine hydroxylase Homo sapiens 10-30 15621715-4 2004 Furthermore, catecholamines such as 3,4-dihydroxyphenylalanine (DOPA), dopamine or norepinephrine were more effective than caffeic acid or pyrocatechol in promoting Cu(2+)-mediated inactivation of PON1, suggesting the importance of dihydroxybenzene group as well as amino group. Catecholamines 13-27 paraoxonase 1 Homo sapiens 197-201 15287903-1 2004 Tyrosine hydroxylase (TyrH), the catalyst for the key regulatory step in catecholamine biosynthesis, is phosphorylated by cAMP-dependent protein kinase A (PKA) on a serine residue in a regulatory domain. Catecholamines 73-86 tyrosine hydroxylase Homo sapiens 0-20 15458278-6 2004 This study clearly demonstrated that endogenous catecholamines elicited immunosuppressive effects through beta2-AR stimulation, possibly due to down-regulation of the expression of ICAM-1, CD40 and CD14 on monocytes. Catecholamines 48-62 adrenoceptor beta 2 Homo sapiens 106-114 15458278-6 2004 This study clearly demonstrated that endogenous catecholamines elicited immunosuppressive effects through beta2-AR stimulation, possibly due to down-regulation of the expression of ICAM-1, CD40 and CD14 on monocytes. Catecholamines 48-62 intercellular adhesion molecule 1 Homo sapiens 181-187 15458278-6 2004 This study clearly demonstrated that endogenous catecholamines elicited immunosuppressive effects through beta2-AR stimulation, possibly due to down-regulation of the expression of ICAM-1, CD40 and CD14 on monocytes. Catecholamines 48-62 CD40 molecule Homo sapiens 189-193 15458278-6 2004 This study clearly demonstrated that endogenous catecholamines elicited immunosuppressive effects through beta2-AR stimulation, possibly due to down-regulation of the expression of ICAM-1, CD40 and CD14 on monocytes. Catecholamines 48-62 CD14 molecule Homo sapiens 198-202 15675612-1 2004 The aim of this study was to shed more light on the developmental characteristics of human paraventricular nucleus (PVN) and hypothalamus in general, using modern immunohistochemical techniques to detect the activity of tyrosine hydroxylase (TH) in the synthesis of catecholamine (CA). Catecholamines 266-279 tyrosine hydroxylase Homo sapiens 220-240 15278367-3 2004 The aims of this work were to (1) characterize catecholamine effects on proliferation, tyrosinase activity and expression, (2) identify the alpha(1)-adrenoceptor subtypes, and (3) verify whether chronic norepinephrine (NE) treatment modified the types and/or pharmacological characteristics of adrenoceptors present in SK-Mel 23 human melanoma cells. Catecholamines 47-60 tyrosinase Homo sapiens 87-97 15287903-0 2004 Effects of phosphorylation by protein kinase A on binding of catecholamines to the human tyrosine hydroxylase isoforms. Catecholamines 61-75 tyrosine hydroxylase Homo sapiens 89-109 15636427-10 2004 In conclusion, VEGF levels were significantly elevated in patients with endocrine hypertension due to glucocorticoid, mineralocorticoid and/or catecholamine excess. Catecholamines 143-156 vascular endothelial growth factor A Homo sapiens 15-19 15236464-0 2004 Cocaine- and amphetamine-regulated transcript in catecholamine and noncatecholamine presympathetic vasomotor neurons of rat rostral ventrolateral medulla. Catecholamines 49-62 CART prepropeptide Rattus norvegicus 0-45 15236464-3 2004 To test this hypothesis, we first used double-immunofluorescence staining for CART and tyrosine hydroxylase (TH) to quantify CART-immunoreactive (-IR) catecholamine and noncatecholamine neurons in the C1 region. Catecholamines 151-164 CART prepropeptide Rattus norvegicus 125-129 15292328-2 2004 Because catecholamines are also substrates for COMT, we hypothesize that catecholamines may abrogate the vasoprotective effects of estradiol by competing for COMT and inhibiting methoxyestradiol formation. Catecholamines 8-22 catechol-O-methyltransferase Homo sapiens 47-51 15292328-2 2004 Because catecholamines are also substrates for COMT, we hypothesize that catecholamines may abrogate the vasoprotective effects of estradiol by competing for COMT and inhibiting methoxyestradiol formation. Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 47-51 15292328-2 2004 Because catecholamines are also substrates for COMT, we hypothesize that catecholamines may abrogate the vasoprotective effects of estradiol by competing for COMT and inhibiting methoxyestradiol formation. Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 158-162 15276011-1 2004 The traditional notion that catecholamine actions are mediated by the predominant beta(1)-adrenergic receptor (beta(1)-AR) subtype linked to the activation of adenylyl cyclase and the accumulation of cyclic adenosine 3",5"-monophosphate (cAMP) in cardiomyocytes has been challenged by recent studies showing that cardiomyocytes co-express pharmacologically distinct beta(2)-AR subtypes that activate a more broad range of downstream effectors. Catecholamines 28-41 adrenoceptor beta 1 Homo sapiens 82-121 15287903-1 2004 Tyrosine hydroxylase (TyrH), the catalyst for the key regulatory step in catecholamine biosynthesis, is phosphorylated by cAMP-dependent protein kinase A (PKA) on a serine residue in a regulatory domain. Catecholamines 73-86 tyrosine hydroxylase Homo sapiens 22-26 15208157-0 2004 Is decreased leptin secretion after alcohol ingestion catecholamine-mediated? Catecholamines 54-67 leptin Homo sapiens 13-19 15266027-0 2004 "Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor. Catecholamines 28-41 adrenoceptor beta 2 Homo sapiens 57-82 15120481-2 2004 Colocalized with catecholamines in chromaffin cells, CgA is a prohormone precursor of small biologically active peptides. Catecholamines 17-31 chromogranin A Rattus norvegicus 53-56 15247489-1 2004 The catecholamine-oxidizing enzyme monoamine oxidase-B (MAO-B) has been hypothesized to be an important determining factor in the etiology of both normal aging and age-related neurological disorders such as Parkinson"s disease (PD). Catecholamines 4-17 monoamine oxidase B Homo sapiens 35-54 15247489-1 2004 The catecholamine-oxidizing enzyme monoamine oxidase-B (MAO-B) has been hypothesized to be an important determining factor in the etiology of both normal aging and age-related neurological disorders such as Parkinson"s disease (PD). Catecholamines 4-17 monoamine oxidase B Homo sapiens 56-61 15223360-2 2004 We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I (GTPCH), rate-limiting enzyme in biosynthesis as well as of tetrahydrobiopterin (BH4), and concentration of BH4, which is an essential cofactor for TH, tryptophan hydroxylase and nitric oxide synthase. Catecholamines 91-104 tyrosine hydroxylase Rattus norvegicus 40-60 15223360-2 2004 We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I (GTPCH), rate-limiting enzyme in biosynthesis as well as of tetrahydrobiopterin (BH4), and concentration of BH4, which is an essential cofactor for TH, tryptophan hydroxylase and nitric oxide synthase. Catecholamines 91-104 tyrosine hydroxylase Rattus norvegicus 62-64 15223360-2 2004 We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I (GTPCH), rate-limiting enzyme in biosynthesis as well as of tetrahydrobiopterin (BH4), and concentration of BH4, which is an essential cofactor for TH, tryptophan hydroxylase and nitric oxide synthase. Catecholamines 91-104 GTP cyclohydrolase 1 Rattus norvegicus 126-146 15211623-6 2004 These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior. Catecholamines 128-141 catechol-O-methyltransferase Homo sapiens 97-101 15211633-2 2004 The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 99-103 15211633-2 2004 The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 204-208 15208157-1 2004 AIMS: Catecholamines (CA) inhibit leptin secretion. Catecholamines 6-20 leptin Homo sapiens 34-40 15178740-15 2004 In the meantime, vasopressin infusion at <or=0.03 units/min should be considered only if response to 1 or 2 catecholamine vasopressors is inadequate or as a method to reduce the dose of these therapies. Catecholamines 111-124 arginine vasopressin Homo sapiens 17-28 15281498-5 2004 An IV infusion of vasopressin was given to prevent systemic hypotension resulting from sympathetic blockade while avoiding increases in pulmonary vascular resistance that may have resulted from catecholamine usage. Catecholamines 194-207 arginine vasopressin Homo sapiens 18-29 15240521-1 2004 PURPOSE: It has been recently shown that the catecholamine neurotransmitter dopamine (DA) strongly and selectively inhibits vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-induced angiogenesis. Catecholamines 45-58 vascular endothelial growth factor A Homo sapiens 189-192 15027894-2 2004 In the present study, we tested for an association of overnight urinary catecholamine and cortisol excretion with morning plasma levels of fibrinogen, PAI-1 (plasminogen activator inhibitor-1) and D-dimer. Catecholamines 72-85 fibrinogen beta chain Homo sapiens 139-149 15027894-2 2004 In the present study, we tested for an association of overnight urinary catecholamine and cortisol excretion with morning plasma levels of fibrinogen, PAI-1 (plasminogen activator inhibitor-1) and D-dimer. Catecholamines 72-85 serpin family E member 1 Homo sapiens 151-156 15027894-2 2004 In the present study, we tested for an association of overnight urinary catecholamine and cortisol excretion with morning plasma levels of fibrinogen, PAI-1 (plasminogen activator inhibitor-1) and D-dimer. Catecholamines 72-85 serpin family E member 1 Homo sapiens 158-191 15240521-1 2004 PURPOSE: It has been recently shown that the catecholamine neurotransmitter dopamine (DA) strongly and selectively inhibits vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-induced angiogenesis. Catecholamines 45-58 vascular endothelial growth factor A Homo sapiens 193-197 15131072-7 2004 This, together with similar spatial distributions and responses to catecholamine doses, suggests that either caspase-3 activation occurs in necrotic as well as apoptotic myocytes or that a large proportion of apoptotic myocytes progress to secondary necrosis in vivo. Catecholamines 67-80 caspase 3 Rattus norvegicus 109-118 15044358-5 2004 In vitro cerulenin treatment reduced CPT-1 activity, which was overcome by cotreating with catecholamine. Catecholamines 91-104 carnitine palmitoyltransferase 1b, muscle Mus musculus 37-42 15240391-11 2004 The lowest concentration of TH mRNA in the AM and SG supports the hypothesis that tyrosine hydroxylation is the rate-limiting step in catecholamine biosynthesis. Catecholamines 134-147 tyrosine hydroxylase Rattus norvegicus 28-30 15309045-4 2004 The first gene codes for catechol-O-methyltransferase, an enzyme involved in catecholamine degradation, and the second gene codes for brain-derived neurotrophic factor, a growth factor implicated in cell survival, synaptogenesis and the development of cortical pyramidal neurons. Catecholamines 77-90 catechol-O-methyltransferase Homo sapiens 25-53 15309045-4 2004 The first gene codes for catechol-O-methyltransferase, an enzyme involved in catecholamine degradation, and the second gene codes for brain-derived neurotrophic factor, a growth factor implicated in cell survival, synaptogenesis and the development of cortical pyramidal neurons. Catecholamines 77-90 brain derived neurotrophic factor Homo sapiens 134-167 15138309-1 2004 Chromogranin B (CgB), a major member of the chromogranin/secretogranin family of catecholamine storage vesicle secretory proteins, plays both intracellular (vesiculogenic) and extracellular (prohormone) roles in the neuroendocrine system, and its biosynthesis and release are under the control of efferent sympathetic nerve traffic ("stimulus-transcription coupling"). Catecholamines 81-94 chromogranin B Homo sapiens 0-14 15138309-1 2004 Chromogranin B (CgB), a major member of the chromogranin/secretogranin family of catecholamine storage vesicle secretory proteins, plays both intracellular (vesiculogenic) and extracellular (prohormone) roles in the neuroendocrine system, and its biosynthesis and release are under the control of efferent sympathetic nerve traffic ("stimulus-transcription coupling"). Catecholamines 81-94 chromogranin B Homo sapiens 16-19 15103690-4 2004 NET was used as a marker for NE axons, whereas the catecholamine synthetic enzyme, tyrosine hydroxylase (TH), served as a label for DA neurons. Catecholamines 51-64 tyrosine hydroxylase Rattus norvegicus 83-103 15240357-9 2004 Our results indicate that SERT function not only restrains stress-induced EPI release but also is required for the increase in adrenal catecholamine synthesis and AT(2) receptor expression. Catecholamines 135-148 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 26-30 15240361-0 2004 Angiotensin II AT1 receptor blockade prolongs the lifespan of spontaneously hypertensive rats and reduces stress-induced release of catecholamines, glucocorticoids, and vasopressin. Catecholamines 132-146 angiotensinogen Rattus norvegicus 0-14 15103461-5 2004 However, vasopressin causes arterial smooth muscle cell contraction through a non-catecholamine receptor pathway, thus it represents an attractive adjunct to the management of septic shock, especially when catecholamines are ineffective. Catecholamines 206-220 arginine vasopressin Homo sapiens 9-20 15127078-3 2004 Z26491) is a polymorphism of the gene encoding COMT, a major enzyme in catecholamine inactivation. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 47-51 15261699-7 2004 As both COMT and MAO genes are involved in degrading catecholamines, we also sought evidence for additive and epistatic effects, but none was observed. Catecholamines 53-67 catechol-O-methyltransferase Homo sapiens 8-12 15189762-6 2004 We can conclude that, similarly to leptin, but differently from adiponectin, the adipose tissue hormone resistin could affect the central mechanisms of feeding by inhibiting catecholamine release in the hypothalamus. Catecholamines 174-187 resistin Homo sapiens 104-112 15240382-0 2004 Angiotensin II AT1 and AT2 receptor types regulate basal and stress-induced adrenomedullary catecholamine production through transcriptional regulation of tyrosine hydroxylase. Catecholamines 92-105 tyrosine hydroxylase Rattus norvegicus 155-175 15240382-1 2004 The sympathoadrenal response to stress includes a profound increase in adrenomedullary catecholamine synthesis driven by stimulation of tyrosine hydroxylase (TH) transcription. Catecholamines 87-100 tyrosine hydroxylase Rattus norvegicus 136-156 15240382-1 2004 The sympathoadrenal response to stress includes a profound increase in adrenomedullary catecholamine synthesis driven by stimulation of tyrosine hydroxylase (TH) transcription. Catecholamines 87-100 tyrosine hydroxylase Rattus norvegicus 158-160 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 tyrosine hydroxylase Mus musculus 118-138 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 tyrosine hydroxylase Mus musculus 140-142 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 dopamine beta hydroxylase Mus musculus 145-170 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 dopamine beta hydroxylase Mus musculus 172-175 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 phenylethanolamine-N-methyltransferase Mus musculus 182-220 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 phenylethanolamine-N-methyltransferase Mus musculus 222-226 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 FBJ osteosarcoma oncogene Mus musculus 250-255 15240402-2 2004 The present study focused on the investigation of changes in gene expression of catecholamine biosynthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) in adrenal medulla of c-fos KO and CRH KO mice stressed by immobilization. Catecholamines 80-93 corticotropin releasing hormone Mus musculus 263-266 15135223-4 2004 The results of Northern blot analysis show that LL exposure reduces mRNA levels for tyrosine hydroxylase (TH) the rate limiting catecholamine biosynthetic enzyme and also of dopamine beta-hydroxylase (DBH) as well as for NPY in SCG to about half the levels in control animals. Catecholamines 128-141 tyrosine hydroxylase Rattus norvegicus 84-104 15059976-3 2004 Here we show that L-dopa, dopamine, and other catecholamines dissolve fibrils of alpha-synuclein and Abeta peptide generated in vitro. Catecholamines 46-60 synuclein, alpha Mus musculus 81-96 15183009-3 2004 Mn was demonstrated to be more toxic in the catecholamine-producing CATH.a cells (EC50 = 60 microM) than in non-catecholaminergic SK-N-SH cells (EC50 = 200 microM). Catecholamines 44-57 cathepsin H Mus musculus 68-72 15469714-0 2004 Modification of Cu,Zn-superoxide dismutase by oxidized catecholamines. Catecholamines 55-69 superoxide dismutase 1 Homo sapiens 16-42 15469714-2 2004 The effect of the oxidized products of catecholamines on the modification of Cu,Zn-superoxide dismutase (SOD) was investigated. Catecholamines 39-53 superoxide dismutase 1 Homo sapiens 77-103 15469714-2 2004 The effect of the oxidized products of catecholamines on the modification of Cu,Zn-superoxide dismutase (SOD) was investigated. Catecholamines 39-53 superoxide dismutase 1 Homo sapiens 105-108 15469714-5 2004 Radical scavengers, azide, N-acetylcysteine, and catalase inhibited the oxidized catecholamine-mediated Cu,Zn-SOD aggregation. Catecholamines 81-94 catalase Homo sapiens 49-57 15469714-5 2004 Radical scavengers, azide, N-acetylcysteine, and catalase inhibited the oxidized catecholamine-mediated Cu,Zn-SOD aggregation. Catecholamines 81-94 superoxide dismutase 1 Homo sapiens 110-113 15469714-7 2004 When Cu,Zn-SOD that had been exposed to catecholamines was subsequently analyzed by an amino acid analysis, the glycine and histidine residues were particularly sensitive. Catecholamines 40-54 superoxide dismutase 1 Homo sapiens 11-14 15469714-8 2004 These results suggest that the modification of Cu,Zn-SOD by oxidized catecholamines might induce the perturbation of cellular antioxidant systems and led to a deleterious cell condition. Catecholamines 69-83 superoxide dismutase 1 Homo sapiens 53-56 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Catecholamines 11-24 interleukin 18 Homo sapiens 128-147 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Catecholamines 11-24 tumor necrosis factor Homo sapiens 149-182 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Catecholamines 11-24 interferon gamma Homo sapiens 187-209 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Catecholamines 11-24 interleukin 10 Homo sapiens 233-238 15457373-8 2004 The impossibility of demonstrating ex vivo the mechanism of catecholamine-mediated regulation that is evident in vitro is perhaps due to our experimental conditions or to substances which in vivo inhibit the action of the catecholamines on magnesium, such as insulin and/or glucose. Catecholamines 60-73 insulin Homo sapiens 259-266 15135223-4 2004 The results of Northern blot analysis show that LL exposure reduces mRNA levels for tyrosine hydroxylase (TH) the rate limiting catecholamine biosynthetic enzyme and also of dopamine beta-hydroxylase (DBH) as well as for NPY in SCG to about half the levels in control animals. Catecholamines 128-141 tyrosine hydroxylase Rattus norvegicus 106-108 15135223-8 2004 The results show, for the first time, that prolonged changes in environmental light can alter the gene expression of catecholamine biosynthetic enzymes and of NPY. Catecholamines 117-130 neuropeptide Y Rattus norvegicus 159-162 15105445-5 2004 Expression of constitutively active Rab4 Q72L had no effects on cardiac structure or function, but dominant inhibitor Rab4 S27N impaired responsiveness to endogenous and exogenous catecholamines. Catecholamines 180-194 RAB4A, member RAS oncogene family Mus musculus 118-122 15105445-12 2004 These data provide evidence for constant bidirectional sarcollemal-vesicular betaAR trafficking in the in vivo heart and show that Rab4-mediated recycling of internalized betaAR is necessary for normal cardiac catecholamine responsiveness and resensitization after agonist exposure. Catecholamines 210-223 RAB4A, member RAS oncogene family Mus musculus 131-135 15105445-12 2004 These data provide evidence for constant bidirectional sarcollemal-vesicular betaAR trafficking in the in vivo heart and show that Rab4-mediated recycling of internalized betaAR is necessary for normal cardiac catecholamine responsiveness and resensitization after agonist exposure. Catecholamines 210-223 adrenoceptor beta 2 Homo sapiens 171-177 15082154-0 2004 Quantal size of catecholamine release from rat chromaffin cells is regulated by tonic activity of protein kinase A. Catecholamines 16-29 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 98-114 15083268-1 2004 Cardiac effects of catecholamines on the L-type calcium channel depend on beta-adrenoceptor subtype (beta(1)- vs. beta(2)-adrenoceptor). Catecholamines 19-33 hemoglobin, beta adult major chain Mus musculus 41-108 15083268-1 2004 Cardiac effects of catecholamines on the L-type calcium channel depend on beta-adrenoceptor subtype (beta(1)- vs. beta(2)-adrenoceptor). Catecholamines 19-33 adrenergic receptor, beta 2 Mus musculus 114-134 15133200-2 2004 It was found that the coordinate r(chi, eta) of electronic structures of neurotransmitters obtained using the parameters eta and chi can be graphically classified into three groups: catecholamine type (group I), gamma-aminobutanoic acid (GABA) type (group II), and acetylcholine (ACh) type (group III) in the eta-chi diagram. Catecholamines 182-195 endothelin receptor type A Homo sapiens 40-43 15133200-2 2004 It was found that the coordinate r(chi, eta) of electronic structures of neurotransmitters obtained using the parameters eta and chi can be graphically classified into three groups: catecholamine type (group I), gamma-aminobutanoic acid (GABA) type (group II), and acetylcholine (ACh) type (group III) in the eta-chi diagram. Catecholamines 182-195 endothelin receptor type A Homo sapiens 121-124 15133200-2 2004 It was found that the coordinate r(chi, eta) of electronic structures of neurotransmitters obtained using the parameters eta and chi can be graphically classified into three groups: catecholamine type (group I), gamma-aminobutanoic acid (GABA) type (group II), and acetylcholine (ACh) type (group III) in the eta-chi diagram. Catecholamines 182-195 endothelin receptor type A Homo sapiens 121-124 14722779-8 2004 The increase in plasma volume (PV) that is associated with a tendency for a decrease in plasma active renin is likely to be due to decreased sympathetic activity, and concords with the changes in urinary catecholamine levels during confinement. Catecholamines 204-217 renin Homo sapiens 102-107 15182744-8 2004 Skeletal muscle microdialysis with local administration of catecholamine offers a new method for in vivo assessment of regional COMT activity. Catecholamines 59-72 catechol O-methyltransferase Oryctolagus cuniculus 128-132 15127327-19 2004 A few-day shift of the preovulatory GnRH/LH surge, as determined by estrous behavior, might, however, be a consequence of the PRL-induced increase in catecholamine turnover in the IN/ME. Catecholamines 150-163 prolactin Ovis aries 126-129 14759560-0 2004 Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. Catecholamines 63-76 chromogranin A Homo sapiens 119-133 14759560-1 2004 Previous modeling (PDB 1cfk) of the catecholamine release-inhibitory "catestatin" region of chromogranin A (CgA) suggested a beta-strand/loop/beta-strand active conformation, displaying an electropositive Arg-rich loop (R(351)AR(353)GYGFR(358)). Catecholamines 36-49 chromogranin A Homo sapiens 92-106 14759560-1 2004 Previous modeling (PDB 1cfk) of the catecholamine release-inhibitory "catestatin" region of chromogranin A (CgA) suggested a beta-strand/loop/beta-strand active conformation, displaying an electropositive Arg-rich loop (R(351)AR(353)GYGFR(358)). Catecholamines 36-49 chromogranin A Homo sapiens 108-111 14684600-10 2004 Collectively, these results indicate that icv-injected IL-1beta or EtOH blunts hCG-induced T secretion through a catecholamine-mediated mechanism that does not depend on either peripherally mediated effects or pituitary LH, and that the PVN plays a role in these effects. Catecholamines 113-126 interleukin 1 beta Homo sapiens 55-63 14684600-10 2004 Collectively, these results indicate that icv-injected IL-1beta or EtOH blunts hCG-induced T secretion through a catecholamine-mediated mechanism that does not depend on either peripherally mediated effects or pituitary LH, and that the PVN plays a role in these effects. Catecholamines 113-126 chorionic gonadotropin subunit beta 5 Homo sapiens 79-82 15046613-3 2004 Indeed, the lack of PI3Kgamma does not modify heart rate and blood pressure, but does increase contractility, particularly in response to stimuli that enhance cardiac contractile force, such as catecholamines. Catecholamines 194-208 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens 20-29 14684600-8 2004 PVN catecholamine turnover significantly increased after icv injection of IL-1beta, but not EtOH. Catecholamines 4-17 interleukin 1 beta Homo sapiens 74-82 14684600-9 2004 Brain catecholamine depletion due to the neurotoxin 6-hydroxydopamine did not alter the ability of hCG to induce T release, but significantly reversed the inhibitory effect of icv EtOH or IL-1beta on this response. Catecholamines 6-19 interleukin 1 beta Homo sapiens 188-196 15090041-5 2004 Therefore, we quantified NPY mRNA hybridization signal in hindbrain catecholamine cell groups 90 min after subcutaneous administration of the glycolytic inhibitor 2-deoxy-d-glucose (2DG, 250 mg/kg) to male rats. Catecholamines 68-81 neuropeptide Y Rattus norvegicus 25-28 15090041-6 2004 Catecholamine cell groups A1, A1/C1 and C2 (that provide the major NPY innervation of the hypothalamus) showed a basal level of NPY mRNA hybridization signal that was dramatically increased by 2DG. Catecholamines 0-13 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 30-42 15090041-6 2004 Catecholamine cell groups A1, A1/C1 and C2 (that provide the major NPY innervation of the hypothalamus) showed a basal level of NPY mRNA hybridization signal that was dramatically increased by 2DG. Catecholamines 0-13 neuropeptide Y Rattus norvegicus 67-70 15090041-6 2004 Catecholamine cell groups A1, A1/C1 and C2 (that provide the major NPY innervation of the hypothalamus) showed a basal level of NPY mRNA hybridization signal that was dramatically increased by 2DG. Catecholamines 0-13 neuropeptide Y Rattus norvegicus 128-131 15090041-9 2004 Hypothalamic microinjection of the retrogradely transported catecholamine immunotoxin saporin conjugated to anti-dopamine-beta-hydroxylase destroyed hindbrain catecholamine/NPY neurons and abolished basal and 2DG-stimulated increases in NPY expression in hindbrain cell groups. Catecholamines 60-73 neuropeptide Y Rattus norvegicus 173-176 15090041-9 2004 Hypothalamic microinjection of the retrogradely transported catecholamine immunotoxin saporin conjugated to anti-dopamine-beta-hydroxylase destroyed hindbrain catecholamine/NPY neurons and abolished basal and 2DG-stimulated increases in NPY expression in hindbrain cell groups. Catecholamines 60-73 neuropeptide Y Rattus norvegicus 237-240 15090041-9 2004 Hypothalamic microinjection of the retrogradely transported catecholamine immunotoxin saporin conjugated to anti-dopamine-beta-hydroxylase destroyed hindbrain catecholamine/NPY neurons and abolished basal and 2DG-stimulated increases in NPY expression in hindbrain cell groups. Catecholamines 159-172 neuropeptide Y Rattus norvegicus 173-176 15256333-0 2004 Catecholamine excess in pheochromocytoma inducing insulin resistance. Catecholamines 0-13 insulin Homo sapiens 50-57 14724289-8 2004 The observation that PEBP and HCNP were secreted with catecholamines into the circulation prompted us to investigate endocrine effects of this peptide on cardiovascular system. Catecholamines 54-68 phosphatidylethanolamine binding protein 1 Bos taurus 21-25 15052282-3 2004 To determine the effect of chronic catecholamine infusion in vivo, we measured apoptosis marker expression in C57Bl/6 and catecholamine-sensitive Egr-1 deficient mice after treatment with the nonspecific beta-adrenergic agonist, isoproterenol, the beta1-specific agonist, dobutamine, or the beta2-specific agonist, metaproterenol. Catecholamines 122-135 early growth response 1 Mus musculus 146-151 15052282-5 2004 Catecholamine-treated mice had decreased Bcl-2 and increased Bax and BNIP1 expression, suggesting mitochondria-dependent apoptosis pathway activation. Catecholamines 0-13 B cell leukemia/lymphoma 2 Mus musculus 41-46 15052282-5 2004 Catecholamine-treated mice had decreased Bcl-2 and increased Bax and BNIP1 expression, suggesting mitochondria-dependent apoptosis pathway activation. Catecholamines 0-13 BCL2-associated X protein Mus musculus 61-64 15052282-5 2004 Catecholamine-treated mice had decreased Bcl-2 and increased Bax and BNIP1 expression, suggesting mitochondria-dependent apoptosis pathway activation. Catecholamines 0-13 BCL2/adenovirus E1B interacting protein 1 Mus musculus 69-74 15052282-8 2004 Clusterin expression was increased in catecholamine-treated mice, but GRP78 expression was not increased, and caspase 12 activation products were not detected. Catecholamines 38-51 clusterin Mus musculus 0-9 15024092-1 2004 It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene. Catecholamines 28-41 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 167-187 15024092-1 2004 It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene. Catecholamines 28-41 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 189-193 15104239-1 2004 Activation of human peripheral blood mononuclear cells (PBMC) triggers endogenous production of catecholamines (CA) through protein kinase (PK) C-dependent induction of tyrosine hydroxylase (TH; EC 1.14.16.2), the first and rate-limiting enzyme in the synthesis of CA. Catecholamines 96-110 tyrosine hydroxylase Homo sapiens 169-189 15104239-1 2004 Activation of human peripheral blood mononuclear cells (PBMC) triggers endogenous production of catecholamines (CA) through protein kinase (PK) C-dependent induction of tyrosine hydroxylase (TH; EC 1.14.16.2), the first and rate-limiting enzyme in the synthesis of CA. Catecholamines 96-110 tyrosine hydroxylase Homo sapiens 191-193 14993794-3 2004 In the adrenal medulla, tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 24-44 14993794-3 2004 In the adrenal medulla, tyrosine hydroxylase (TH) is the first enzyme in the pathway of catecholamine synthesis. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 46-48 14740315-0 2004 Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Catecholamines 91-104 chromogranin A Homo sapiens 70-74 14715701-0 2004 Catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human monocytes and in the human monocytic cell line U937: possible implications for peri-operative plaque instability. Catecholamines 0-14 matrix metallopeptidase 1 Homo sapiens 52-57 14715701-0 2004 Catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human monocytes and in the human monocytic cell line U937: possible implications for peri-operative plaque instability. Catecholamines 0-14 matrix metallopeptidase 9 Homo sapiens 62-67 14715701-6 2004 We further characterized this effect employing the monocytic cell line U937 and showed that catecholamines potentiate LPS-induced effects on MMP-1 and MMP-9 antigen and activity. Catecholamines 92-106 matrix metallopeptidase 1 Homo sapiens 141-146 14715701-6 2004 We further characterized this effect employing the monocytic cell line U937 and showed that catecholamines potentiate LPS-induced effects on MMP-1 and MMP-9 antigen and activity. Catecholamines 92-106 matrix metallopeptidase 9 Homo sapiens 151-156 14767563-6 2004 Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of catecholamine neurotransmitters is a crucial first-line detoxification pathway, and its role in the causation and prevention of PD is also discussed. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 0-28 14767563-6 2004 Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of catecholamine neurotransmitters is a crucial first-line detoxification pathway, and its role in the causation and prevention of PD is also discussed. Catecholamines 71-84 catechol-O-methyltransferase Homo sapiens 30-34 14767563-7 2004 On the basis of the modulation of COMT-mediated methylation of catecholamines, it is mechanistically explained that hyperhomocysteinemia would be a pathogenic factor in PD whereas vitamins B6, B12, and folate would be a protective factor. Catecholamines 63-77 catechol-O-methyltransferase Homo sapiens 34-38 15124352-4 2004 It was already shown that, in addition to the GnRH-immunoreactive neurons, a small amount of neurons expressing tyrosine hydroxylase (TH), the first enzyme of catecholamine synthesis, migrates into the forebrain. Catecholamines 159-172 tyrosine hydroxylase Rattus norvegicus 112-132 15124352-9 2004 However, single nonenzymatic DAA-immunoreactive neurons were found in the area of anterior olfactory nuclei in the forebrain, which suggests their involvement in local cooperative synthesis of catecholamines in the area where GnRH-immunoreactive neurons penetrate in the forebrain. Catecholamines 193-207 gonadotropin releasing hormone 1 Rattus norvegicus 226-230 14740315-2 2004 Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release-inhibitory) mechanisms. Catecholamines 32-45 chromogranin A Homo sapiens 0-14 14740315-2 2004 Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release-inhibitory) mechanisms. Catecholamines 32-45 chromogranin A Homo sapiens 16-20 14740315-2 2004 Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release-inhibitory) mechanisms. Catecholamines 123-136 chromogranin A Homo sapiens 0-14 14740315-2 2004 Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (catecholamine release-inhibitory) mechanisms. Catecholamines 123-136 chromogranin A Homo sapiens 16-20 14740315-5 2004 Functional variants include both common alleles that quantitatively alter gene expression and rare alleles that qualitatively change the encoded product to alter the signaling potency of CHGA-derived catecholamine release-inhibitory catestatin peptides. Catecholamines 200-213 chromogranin A Homo sapiens 187-191 14742996-3 2004 We examined the effects of endogenous catecholamines and beta2-AR agonists on the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) in human mixed lymphocyte reaction (MLR) and in an in vitro model of acute rejection in the presence or absence of IL-18. Catecholamines 38-52 intercellular adhesion molecule 1 Homo sapiens 96-136 14610528-10 2004 CONCLUSION: Multiple SNPs in the beta(2)-adrenoceptor gene form several haplotypes that markedly influence beta(2)-receptor function- and catecholamine-induced lipolysis in fat cells. Catecholamines 138-151 adrenoceptor beta 2 Homo sapiens 33-53 14966473-1 2004 Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 0-28 14966473-1 2004 Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 30-34 15031547-1 2004 Catechol O-methyltransferase (COMT) inactivates catecholamines and catechol-containing drugs such as L-DOPA. Catecholamines 48-62 catechol-O-methyltransferase Canis lupus familiaris 0-28 15031547-1 2004 Catechol O-methyltransferase (COMT) inactivates catecholamines and catechol-containing drugs such as L-DOPA. Catecholamines 48-62 catechol-O-methyltransferase Canis lupus familiaris 30-34 21162290-6 2004 CONCLUSION: In acute myocardial ischemia condition, toxic metabolite LPC accentuated its inhibitory effect on pacemaker current I(f), a local release and accumulation of catecholamine could not completely reverse their inhibitory effect. Catecholamines 170-183 proprotein convertase subtilisin/kexin type 7 Homo sapiens 69-72 14726153-1 2004 The present study investigated the involvement of catecholamines in stress-mediated alterations in CYP1A1 induction by benzo(alpha)pyrene (B(alpha)P) in Wistar rats. Catecholamines 50-64 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 99-105 14681933-4 2004 To test this hypothesis, we examined the electron microscopic localization of DAT and the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), in the VPm and VPl of rat brain. Catecholamines 90-103 tyrosine hydroxylase Rattus norvegicus 125-145 14559905-4 2004 We used fluorescence spectroscopy to monitor catecholamine-induced conformational changes in purified beta2AR. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 102-109 14697237-1 2004 Angiotensin II acting centrally contributes to the regulation of blood pressure and water intake and stimulates the release of catecholamines from the adrenal medulla. Catecholamines 127-141 angiotensinogen Rattus norvegicus 0-14 14697237-2 2004 We hypothesized that the central angiotensin II is one mediator of biosynthesis of catecholamines in the adrenal medulla. Catecholamines 83-97 angiotensinogen Rattus norvegicus 33-47 14697237-8 2004 In conclusion, one component of central angiotensin II elevation of blood pressure may be the result of increased catecholamine synthesis in the adrenal gland and elevated TH synthesis represents one underlying mechanism. Catecholamines 114-127 angiotensinogen Rattus norvegicus 40-54 14697247-0 2004 Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma. Catecholamines 77-91 haptoglobin Mus musculus 14-25 14559905-2 2004 The beta2 adrenoreceptor (beta2AR) is a prototypical G protein-coupled receptor (GPCR) activated by catecholamines. Catecholamines 100-114 adrenoceptor beta 2 Homo sapiens 4-24 14559905-2 2004 The beta2 adrenoreceptor (beta2AR) is a prototypical G protein-coupled receptor (GPCR) activated by catecholamines. Catecholamines 100-114 adrenoceptor beta 2 Homo sapiens 26-33 14726153-13 2004 In summary, regulation of induction of hepatic CYP1A1 during stress appears to involve various components of the stress system, including central and peripheral catecholamines, which interact in a complex manner, yet to be elucidated. Catecholamines 161-175 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 47-53 15633814-1 2004 We have previously shown that electroacupuncture (EA) at Shaohai and Neiguan (HT3-PC6) points significantly attenuated stress-induced peripheral responses, including increases in blood pressure, heart rate and plasma catecholamines. Catecholamines 217-231 proprotein convertase subtilisin/kexin type 5 Rattus norvegicus 82-85 14678347-11 2004 The attenuated beta2-adrenoceptor response in the Gly16-Glu27 haplotype would be in keeping with increased susceptibility to prior down-regulation by endogenous catecholamines. Catecholamines 161-175 adrenoceptor beta 2 Homo sapiens 15-33 15176429-0 2004 A missense mutation in CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Catecholamines 68-81 calsequestrin 2 Homo sapiens 23-28 14685702-3 2004 Physiological dampeners of TNFalpha production, such as interleukin-10, catecholamines, cortisol, and others fail in the course of the disease. Catecholamines 72-86 tumor necrosis factor Homo sapiens 27-35 14512436-9 2004 Infusion of AngII increased catecholamine turnover in adipose tissue. Catecholamines 28-41 angiotensinogen Rattus norvegicus 12-17 15305765-18 2004 In shock states with the deficit of endogenous vasopressin, which are resistant to high doses of catecholamines, administration of vasopressin analogues represents a new perspective therapy. Catecholamines 97-111 arginine vasopressin Homo sapiens 47-58 15305765-18 2004 In shock states with the deficit of endogenous vasopressin, which are resistant to high doses of catecholamines, administration of vasopressin analogues represents a new perspective therapy. Catecholamines 97-111 arginine vasopressin Homo sapiens 131-142 14693408-9 2004 However, increased sensitivity to catecholamine-induced lipolysis of the Gly allele promotes higher free fatty acids concentrations in the portal system, which could enhance the higher levels of fasting insulin. Catecholamines 34-47 insulin Homo sapiens 203-210 15118357-1 2004 The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 96-110 catechol-O-methyltransferase Homo sapiens 20-48 15080578-1 2004 BACKGROUND: In rats leptin increases sympathetic activity, and an inhibitory effect on leptin synthesis and release has been demonstrated for the catecholamines, both in adipocyte cell cultures and in healthy experimental animals. Catecholamines 146-160 leptin Rattus norvegicus 87-93 12955521-2 2004 Both circulating catecholamine levels and exercise intensity have been related to the exercise-derived IL-6. Catecholamines 17-30 interleukin 6 Homo sapiens 103-107 12955521-4 2004 Therefore, hypoxia offers a unique opportunity to study the effect of catecholamines and intensity on exercise-derived IL-6. Catecholamines 70-84 interleukin 6 Homo sapiens 119-123 15253131-2 2004 Nerve fibres supplying the urethral muscle were found to show NADPH-d activity and they also expressed immunoreactivity to catecholamine synthesising enzymes including tyrosine hydoxylase (TH) and dopamine-beta-hydroxylase (DbetaH) as well as to: vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Catecholamines 123-136 vasoactive intestinal peptide Sus scrofa 247-280 15253131-2 2004 Nerve fibres supplying the urethral muscle were found to show NADPH-d activity and they also expressed immunoreactivity to catecholamine synthesising enzymes including tyrosine hydoxylase (TH) and dopamine-beta-hydroxylase (DbetaH) as well as to: vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Catecholamines 123-136 vasoactive intestinal peptide Sus scrofa 282-285 15253131-2 2004 Nerve fibres supplying the urethral muscle were found to show NADPH-d activity and they also expressed immunoreactivity to catecholamine synthesising enzymes including tyrosine hydoxylase (TH) and dopamine-beta-hydroxylase (DbetaH) as well as to: vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Catecholamines 123-136 neuropeptide Y Sus scrofa 291-305 15253131-2 2004 Nerve fibres supplying the urethral muscle were found to show NADPH-d activity and they also expressed immunoreactivity to catecholamine synthesising enzymes including tyrosine hydoxylase (TH) and dopamine-beta-hydroxylase (DbetaH) as well as to: vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Catecholamines 123-136 neuropeptide Y Sus scrofa 307-310 15141475-2 2004 To assess whether the two key-enzymes involved in the synthesis of catecholamines are present in human testis we examined the expression of Tirosine Hydroxylase (TH) and Dopamine-beta-Hydroxylase (DBH) antigens by immunoperoxidase and immunofluorescence techniques. Catecholamines 67-81 dopamine beta-hydroxylase Homo sapiens 170-195 15141475-2 2004 To assess whether the two key-enzymes involved in the synthesis of catecholamines are present in human testis we examined the expression of Tirosine Hydroxylase (TH) and Dopamine-beta-Hydroxylase (DBH) antigens by immunoperoxidase and immunofluorescence techniques. Catecholamines 67-81 dopamine beta-hydroxylase Homo sapiens 197-200 14716684-1 2004 BACKGROUND: The norepinephrine transporter (NET) is a high-affinity transporter for catecholamines. Catecholamines 84-98 solute carrier family 6 member 2 Rattus norvegicus 16-42 14716684-1 2004 BACKGROUND: The norepinephrine transporter (NET) is a high-affinity transporter for catecholamines. Catecholamines 84-98 solute carrier family 6 member 2 Rattus norvegicus 44-47 14716684-15 2004 CONCLUSIONS: Transduction of tumor cells with NET cDNA causes highly specific uptake and significant retention of catecholamine analogs in vitro and in vivo. Catecholamines 114-127 solute carrier family 6 member 2 Rattus norvegicus 46-49 14675149-9 2004 Collectively, these results imply that CDK11p110 and CK2 negatively regulate TH catecholamine biosynthetic activity since phosphoserine 19 of TH requires 14-3-3 binding for optimal enzyme activity and a decreased rate of dephosphorylation. Catecholamines 80-93 cyclin dependent kinase 11B Homo sapiens 39-48 14758053-2 2004 METHODS: Immunohistochemistry for lymphoid organs (mesenteric lymph nodes, spleen and thymus) and lymphocytes was used to observe their expression of tyrosine hydroxylase (TH), an initial rate-limiting enzyme of the catecholamine synthesis. Catecholamines 216-229 tyrosine hydroxylase Homo sapiens 150-170 15118357-1 2004 The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. Catecholamines 96-110 catechol-O-methyltransferase Homo sapiens 50-54 15545008-9 2004 In the rat brain, the most prominent observation was the revelation of all catecholamine cells (dopamine, norepinephrine, epinephrine) by the flotillin-1 antibody (1:100 dilution). Catecholamines 75-88 flotillin 1 Rattus norvegicus 142-153 14697878-1 2004 Monoamine oxidase (MAO) A and B play important roles in the metabolism of catecholamines and xenobiotics in the central nervous system and peripheral tissues. Catecholamines 74-88 monoamine oxidase A Homo sapiens 0-25 15381390-2 2004 Human platelets synthesize nitric oxide (NO) through an endothelial-type NO synthase (ecNOS) activated also by substances enhancing 3",5"-cyclic adenosine monophosphate (cAMP) concentrations, such as catecholamines, beta-adrenoceptor agonists and adenosine. Catecholamines 200-214 nitric oxide synthase 3 Homo sapiens 86-91 15536395-7 2004 Efforts directed towards improving the pharmacodynamic and pharmacokinetic properties, including the long-acting and selective beta2-adrenoceptor agonists, included two major pathways of modifying the basic structure of the catecholamines, which are described in this paper. Catecholamines 224-238 adrenoceptor beta 2 Homo sapiens 127-145 15579641-8 2004 Neurons expressing tyrosine hydroxylase (TH) were killed by 6-hydroxydopamine (6-OHDA), a neurotoxic catecholamine. Catecholamines 101-114 tyrosine hydroxylase Homo sapiens 19-39 14639047-1 2003 OBJECTIVE: Glutathione-S-transferases, NAD(P)H: quinone oxidoreductase1 (NQO1) and NRH: quinone oxidoreductase2 (NQO2) provide important cellular defences against the neurotoxicity induced by catecholamine-derived o-quinones and oxidative stress during redox cycling. Catecholamines 192-205 NAD(P)H quinone dehydrogenase 1 Homo sapiens 39-71 14651989-1 2003 Tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis, is predominantly expressed in several cell groups within the brain, including the dopaminergic (DA) neurons of the substantia nigra and ventral tegmental area, and the noradrenergic neurons of the locus coeruleus. Catecholamines 55-68 tyrosine hydroxylase Homo sapiens 0-20 14651989-1 2003 Tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis, is predominantly expressed in several cell groups within the brain, including the dopaminergic (DA) neurons of the substantia nigra and ventral tegmental area, and the noradrenergic neurons of the locus coeruleus. Catecholamines 55-68 tyrosine hydroxylase Homo sapiens 22-24 14685697-2 2003 Expression of leptin is regulated by dietary status, insulin, glucocorticoids and catecholamines. Catecholamines 82-96 leptin Rattus norvegicus 14-20 14608456-13 2003 In contrast, (-)-pindolol blocks the effects of catecholamines through a high-affinity site of the beta(1)-adrenoceptor. Catecholamines 48-62 adrenoceptor beta 1 Homo sapiens 99-119 15898827-7 2004 In several life-threatening poisonings in humans, the administration of high-dose insulin produced cardiovascular stabilisation, decreased the catecholamine vasopressor infusion rate and improved the survival rate. Catecholamines 143-156 insulin Homo sapiens 82-89 14609565-2 2003 Cortisol and catecholamines have been shown to be important costimulatory factors for IL-10 secretion in humans. Catecholamines 13-27 interleukin 10 Homo sapiens 86-91 14641008-2 2003 In adipocytes, catecholamines stimulate lipolysis mainly through PKA (protein kinase A)-mediated phosphorylation of HSL and perilipin, a protein coating the lipid droplet. Catecholamines 15-29 lipase, hormone sensitive Mus musculus 116-119 14641008-6 2003 Adipocytes isolated from homozygous HSL-null mice, generated in our laboratory, exhibit completely blunted catecholamine-induced glycerol release and reduced fatty acid release, suggesting the presence of additional, although not necessarily hormone-activatable, triacylglycerol lipase(s). Catecholamines 107-120 lipase, hormone sensitive Mus musculus 36-39 14639047-1 2003 OBJECTIVE: Glutathione-S-transferases, NAD(P)H: quinone oxidoreductase1 (NQO1) and NRH: quinone oxidoreductase2 (NQO2) provide important cellular defences against the neurotoxicity induced by catecholamine-derived o-quinones and oxidative stress during redox cycling. Catecholamines 192-205 NAD(P)H quinone dehydrogenase 1 Homo sapiens 73-77 14639047-1 2003 OBJECTIVE: Glutathione-S-transferases, NAD(P)H: quinone oxidoreductase1 (NQO1) and NRH: quinone oxidoreductase2 (NQO2) provide important cellular defences against the neurotoxicity induced by catecholamine-derived o-quinones and oxidative stress during redox cycling. Catecholamines 192-205 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 113-117 14612574-1 2003 Two subtypes of beta-adrenoceptors, beta 1 and beta 2, mediate cardiac catecholamine effects. Catecholamines 71-84 hemoglobin, beta adult minor chain Mus musculus 16-53 14610262-5 2003 However, intense exercise provokes the release of insulin-counter regulatory hormones such as glucagons and catecholamines, which ultimately cause a reduction in the insulin action. Catecholamines 108-122 insulin Homo sapiens 50-57 14615493-3 2003 The beta1 subtype is the most prominent one and is mainly responsible for positive chronotropic and inotropic effects of catecholamines. Catecholamines 121-135 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 4-9 14622167-0 2003 Catecholamine-independent transient expression of tyrosine hydroxylase in primary auditory neurons is coincident with the onset of hearing in the rat cochlea. Catecholamines 0-13 tyrosine hydroxylase Rattus norvegicus 50-70 14610262-5 2003 However, intense exercise provokes the release of insulin-counter regulatory hormones such as glucagons and catecholamines, which ultimately cause a reduction in the insulin action. Catecholamines 108-122 insulin Homo sapiens 166-173 14622167-1 2003 During the last stages of neuronal maturation, tyrosine hydroxylase is transiently expressed in the absence of the other catecholamine-synthesizing enzymes. Catecholamines 121-134 tyrosine hydroxylase Rattus norvegicus 47-67 14714585-1 2003 We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Catecholamines 48-62 catechol-O-methyltransferase Rattus norvegicus 66-94 14622112-1 2003 Sulfotransferase (SULT) 1A3 catalyzes the sulfate conjugation of catecholamines and structurally related drugs. Catecholamines 65-79 sulfotransferase family 1A member 3 Homo sapiens 0-27 14517224-0 2003 Delayed maturation of catecholamine phenotype in nucleus tractus solitarius of rats with glial angiotensinogen depletion. Catecholamines 22-35 angiotensinogen Rattus norvegicus 95-110 14517224-2 2003 Recent in vitro studies have suggested that angiotensin II modulates noradrenergic neurotransmission by controlling both the expression and neuritic trafficking of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 219-232 angiotensinogen Rattus norvegicus 44-58 14517224-2 2003 Recent in vitro studies have suggested that angiotensin II modulates noradrenergic neurotransmission by controlling both the expression and neuritic trafficking of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 219-232 tyrosine hydroxylase Rattus norvegicus 164-184 14517224-2 2003 Recent in vitro studies have suggested that angiotensin II modulates noradrenergic neurotransmission by controlling both the expression and neuritic trafficking of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 219-232 tyrosine hydroxylase Rattus norvegicus 186-188 14597102-2 2003 Others have shown that Langerhans cells (LC) express mRNA for beta1-, beta2- and alpha1(A)-(ARs) and that catecholamines may inhibit the antigen-presenting capability via beta2-ARs. Catecholamines 106-120 hemoglobin, beta adult minor chain Mus musculus 171-176 14714585-1 2003 We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Catecholamines 48-62 catechol-O-methyltransferase Rattus norvegicus 96-100 14511124-2 2003 Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme in melanin biosynthesis via the production of DOPA and subsequent molecules, may potentially accelerate the induction of catecholamine quinone derivatives by its oxidase activity. Catecholamines 79-93 tyrosinase Homo sapiens 95-105 14592784-0 2003 PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Catecholamines 47-60 parathyroid hormone Homo sapiens 0-3 14592784-1 2003 Increased free intracellular calcium ([Ca(2+)](i)) in adipocytes blunts the lipolytic response to catecholamines by activating phosphodiesterase 3B - the same enzyme that mediates the antilipolytic effect of insulin - while also compromising the efficiency of insulin-stimulated glucose uptake. Catecholamines 98-112 insulin Homo sapiens 208-215 14592784-1 2003 Increased free intracellular calcium ([Ca(2+)](i)) in adipocytes blunts the lipolytic response to catecholamines by activating phosphodiesterase 3B - the same enzyme that mediates the antilipolytic effect of insulin - while also compromising the efficiency of insulin-stimulated glucose uptake. Catecholamines 98-112 insulin Homo sapiens 260-267 14612158-1 2003 The vesicular monoamine transporter-2 (VMAT-2) facilitates the sequestration of catecholamines and serotonin into synaptic vesicles, and is therefore an essential regulator of monoaminergic neuronal function. Catecholamines 80-94 solute carrier family 18 member A2 Homo sapiens 4-37 14612158-1 2003 The vesicular monoamine transporter-2 (VMAT-2) facilitates the sequestration of catecholamines and serotonin into synaptic vesicles, and is therefore an essential regulator of monoaminergic neuronal function. Catecholamines 80-94 solute carrier family 18 member A2 Homo sapiens 39-45 12962911-0 2003 Prolactin-releasing peptide stimulates catecholamine release but not proliferation in rat pheochromocytoma PC12 cells. Catecholamines 39-52 prolactin releasing hormone Rattus norvegicus 0-27 12962911-1 2003 We examined the effect of prolactin-releasing peptide (PrRP) on catecholamine secretion and DNA synthesis in rat pheochromocytoma PC12 cells. Catecholamines 64-77 prolactin releasing hormone Rattus norvegicus 26-53 12962911-1 2003 We examined the effect of prolactin-releasing peptide (PrRP) on catecholamine secretion and DNA synthesis in rat pheochromocytoma PC12 cells. Catecholamines 64-77 prolactin releasing hormone Rattus norvegicus 55-59 12962911-9 2003 These results indicate that PrRP may regulate catecholamine secretion but not the mitogenic effects in chromaffin cells. Catecholamines 46-59 prolactin releasing hormone Rattus norvegicus 28-32 12869545-0 2003 A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. Catecholamines 106-119 thyroid hormone receptor alpha Mus musculus 2-32 12869545-9 2003 In conclusion, the TRalpha P398H mutation is associated with visceral adiposity and insulin resistance primarily due to a marked reduction in catecholamine-stimulated lipolysis. Catecholamines 142-155 guanine nucleotide binding protein, alpha transducing 1 Mus musculus 19-26 14610298-4 2003 Clusters of NPY-producing neurons in the ARC that coexpress gamma- amino butyric acid and agouti-related peptide, and those in the brain stem (BS) that coexpress catecholamines and galanin, participate in disparate manners to regulate appetitive behavior. Catecholamines 162-176 neuropeptide Y Homo sapiens 12-15 12897061-0 2003 Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2). Catecholamines 17-30 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 105-110 12897061-1 2003 Ascorbic acid (vitamin C) is a cofactor required in catecholamine synthesis for conversion of dopamine to norepinephrine by dopamine beta-hydroxylase. Catecholamines 52-65 dopamine beta hydroxylase Mus musculus 124-149 14553900-2 2003 The novel CgA fragment catestatin (bovine CgA(344-364); RSMRLSFRARGYGFRGPGLQL) is a potent inhibitor of catecholamine release by acting as a nicotinic cholinergic antagonist. Catecholamines 104-117 chromogranin A Bos taurus 10-13 14553900-2 2003 The novel CgA fragment catestatin (bovine CgA(344-364); RSMRLSFRARGYGFRGPGLQL) is a potent inhibitor of catecholamine release by acting as a nicotinic cholinergic antagonist. Catecholamines 104-117 chromogranin A Homo sapiens 23-33 14553900-2 2003 The novel CgA fragment catestatin (bovine CgA(344-364); RSMRLSFRARGYGFRGPGLQL) is a potent inhibitor of catecholamine release by acting as a nicotinic cholinergic antagonist. Catecholamines 104-117 chromogranin A Bos taurus 42-45 14519424-7 2003 GRKs phosphorylate betaARs, blocking downstream-signaling cascades and ultimately desensitizing the receptor to further catecholamine stimuli. Catecholamines 120-133 G protein-coupled receptor kinase 4 Mus musculus 0-4 14562217-0 2003 [Vasopressin analogue injection as ultimate measure for counteracting severe catecholamine-refractory poisoning by several vasodilators taken with suicidal intent]. Catecholamines 77-90 arginine vasopressin Homo sapiens 1-12 14562217-6 2003 CONCLUSION: In circulatory shock due to toxic vasodilatation the use of vasopressin analogue argipressin can be helpful as an ultima therapeutic measure in catecholamine refractory shock caused by vasodilatation. Catecholamines 156-169 arginine vasopressin Homo sapiens 72-83 12897061-7 2003 On the ultrastructural level, adrenal chromaffin cells in SVCT2 null mice showed depletion of catecholamine storage vesicles, increased amounts of rough endoplasmic reticulum, signs of apoptosis, and increased glycogen storage. Catecholamines 94-107 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 58-63 12897061-9 2003 These data show that deranged catecholamine system function in SVCT2 null mice is largely restricted to the adrenal medulla and cannot account for the lethality in these animals. Catecholamines 30-43 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 63-68 14530473-2 2003 This study examined the effects of normal human aging on cardiac sympathetic innervation and function, including the neuronal uptake of catecholamines (uptake 1) via the cell membrane norepinephrine transporter. Catecholamines 136-150 solute carrier family 6 member 2 Homo sapiens 184-210 14511124-5 2003 Interestingly, the expressed tyrosinase protein was initially distributed in the entire cytoplasm and then accumulated to form catecholamine-positive granular structures by 3 days after the induction. Catecholamines 127-140 tyrosinase Homo sapiens 29-39 14523327-2 2003 Catecholamines, used under clinical conditions to maintain adequate cerebral perfusion pressure, induce a sustained IL-6 release. Catecholamines 0-14 interleukin 6 Homo sapiens 116-120 14583654-8 2003 Our results indicate that SERT is necessary for the stress-induced increase in adrenomedullary catecholamine synthesis and AT(2) receptor expression. Catecholamines 95-108 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 26-30 12970108-9 2003 Substitution of Ser200 or Ser204 with cysteine caused a deterioration in the capability of catecholamines to activate the alpha2A-adrenoceptor. Catecholamines 91-105 adrenoceptor alpha 2A Homo sapiens 122-142 14583654-0 2003 The serotonin transporter is required for stress-evoked increases in adrenal catecholamine synthesis and angiotensin II AT(2) receptor expression. Catecholamines 77-90 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 4-25 12963416-4 2003 In the presence of neostigmine (an acetylcholinesterase inhibitor), both exogenous and endogenous acetylcholine-induced catecholamine release was enhanced. Catecholamines 120-133 acetylcholinesterase Rattus norvegicus 35-55 12827645-1 2003 We previously reported a brain-specific 40 kDa catecholamine-regulated protein (CRP40) that binds dopamine (DA) and related catecholamines. Catecholamines 124-138 heat shock protein family A (Hsp70) member 9 Rattus norvegicus 80-85 14519412-4 2003 administered corticotropin-releasing hormone (CRH) increases plasma catecholamines through brain cyclooxygenase-dependent mechanisms in rats. Catecholamines 68-82 corticotropin releasing hormone Rattus norvegicus 13-44 14519412-4 2003 administered corticotropin-releasing hormone (CRH) increases plasma catecholamines through brain cyclooxygenase-dependent mechanisms in rats. Catecholamines 68-82 corticotropin releasing hormone Rattus norvegicus 46-49 14519412-5 2003 In the present experiments, therefore, we examined whether NO is involved in the CRH-induced increase of plasma catecholamines using urethane-anesthetized rats. Catecholamines 112-126 corticotropin releasing hormone Rattus norvegicus 81-84 14519412-11 2003 The CRH-induced increase of plasma catecholamines was also reduced either by cycloheximide (an inhibitor of protein synthesis) [107 nmol (30 microg)/animal, i.c.v.] Catecholamines 35-49 corticotropin releasing hormone Rattus norvegicus 4-7 14646999-4 2003 METHODS: The published findings from human mental stress models on catecholamines, cortisol, prolactin levels and on T helper (Th) 1 and 2-induced cytokines are presented and discussed with respect to the in vitro and in vivo effects of glucocorticoids, catecholamines, and prolactin on the induction of cytokines. Catecholamines 254-268 negative elongation factor complex member C/D Homo sapiens 117-138 14582449-1 2003 p38 Mitogen-activated protein kinase (MAPK) has been implicated in cardiovascular disease and is activated by various factors, including neurohormones (e.g., catecholamines, angiotensin II and endothelin), hypoxia and wall stress. Catecholamines 158-172 mitogen-activated protein kinase 14 Homo sapiens 0-3 13680837-1 2003 The aqueous extract of Mallotus japonicus (Euphorbiaceae) showed an inhibitory effect on bovine adrenal tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamine. Catecholamines 179-192 tyrosine hydroxylase Bos taurus 104-124 12913061-2 2003 Catecholamines are also substrates for catechol-O-methyltransferase and therefore, might abrogate the renoprotective effects of estradiol by inhibiting formation of methoxyestradiols. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 39-67 14502490-3 2003 The evaluated SULT1A3 substrate data set consisted of 95 different substituted phenols, catechols, catecholamines, steroids, and related structures for which the K(m) values were available. Catecholamines 99-113 sulfotransferase family 1A member 3 Homo sapiens 14-21 13680837-1 2003 The aqueous extract of Mallotus japonicus (Euphorbiaceae) showed an inhibitory effect on bovine adrenal tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamine. Catecholamines 179-192 tyrosine hydroxylase Bos taurus 126-128 12796491-10 2003 In previous studies, the 3"-UTR of LPL was critical for the inhibitory effects of constitutively expressed hormones, such as thyroid hormone and catecholamines. Catecholamines 145-159 lipoprotein lipase Mus musculus 35-38 12873956-0 2003 Early use of small-dose vasopressin for unstable hemodynamics in an acute brain injury patient refractory to catecholamine treatment: a case report. Catecholamines 109-122 arginine vasopressin Homo sapiens 24-35 12954358-8 2003 In the present study, therefore, we tried to identify which pathway is involved in the CRH-induced elevation of plasma catecholamines in urethane-anesthetized rats. Catecholamines 119-133 corticotropin releasing hormone Rattus norvegicus 87-90 12915647-2 2003 Data from animal and evidence from clinical studies suggest that catecholamines can induce insulin resistance. Catecholamines 65-79 insulin Homo sapiens 91-98 12909312-1 2003 OBJECTIVES: The regulation of cardiac function by catecholamines involves three populations of beta-adrenoceptor (beta-AR). Catecholamines 50-64 adrenergic receptor, beta 1 Mus musculus 114-121 12924999-2 2003 Amperometric determination of depolarization-dependent catecholamine release from individual intact cells treated with actin or myosin inhibitors showed alterations in the fast and slow phases of secretion when compared with untreated cells. Catecholamines 55-68 actin epsilon 1 Bos taurus 119-124 12915647-10 2003 CONCLUSION: Our data provide evidence that endogenous catecholamine excess in patients with pheochromocytoma can induce or aggravate insulin resistance both in patients with type 2 diabetes and patients with normal glucose tolerance. Catecholamines 54-67 insulin Homo sapiens 133-140 12859689-7 2003 In CT-1-treated cells, depolarization caused a small increase in BH4 and NE uptake, and a large increase in catecholamines. Catecholamines 108-122 cardiotrophin 1 Homo sapiens 3-7 12859624-8 2003 To investigate the potential biological applications of this chemistry the system was also examined by tyrosinase-catalysed oxidation of the catecholamine substrates in which there is re-oxidation of the catechol formed by the redox exchange reaction and enables measurement of oxygen utilization stoichiometry. Catecholamines 141-154 tyrosinase Homo sapiens 103-113 12859689-3 2003 CT-1, but not IL-6 or TNFalpha, suppressed NE uptake and catecholamines in these neurons, whereas CT-1 and, to a lesser extent, IL-6 decreased BH4 content. Catecholamines 57-71 cardiotrophin 1 Homo sapiens 0-4 12887699-5 2003 Central catecholamine depletion induced an inhibition of splenic and blood lymphocyte proliferation and splenic cytokine production and expression (interleukin-2 and interferon-gamma) 7 days after injection. Catecholamines 8-21 interleukin 2 Rattus norvegicus 148-161 12887699-5 2003 Central catecholamine depletion induced an inhibition of splenic and blood lymphocyte proliferation and splenic cytokine production and expression (interleukin-2 and interferon-gamma) 7 days after injection. Catecholamines 8-21 interferon gamma Rattus norvegicus 166-182 12764077-2 2003 Using gene-targeted mice we demonstrate that two distinct subtypes of alpha2-adrenoceptors control release of catecholamines from sympathetic nerves (alpha 2A) and from the adrenal medulla (alpha 2C). Catecholamines 110-124 adrenergic receptor, alpha 2a Mus musculus 70-90 12764077-2 2003 Using gene-targeted mice we demonstrate that two distinct subtypes of alpha2-adrenoceptors control release of catecholamines from sympathetic nerves (alpha 2A) and from the adrenal medulla (alpha 2C). Catecholamines 110-124 adrenergic receptor, alpha 2a Mus musculus 150-158 12764077-4 2003 The inhibitory effects of alpha2-agonists on cell capacitance, voltage-activated Ca2+ currents, and on catecholamine secretion were completely abolished in chromaffin cells isolated from alpha 2C-receptor-deficient mice. Catecholamines 103-116 adrenergic receptor, alpha 2c Mus musculus 187-195 12847066-0 2003 Beta1-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitation. Catecholamines 70-83 adrenoceptor beta 1 Canis lupus familiaris 0-25 12832289-1 2003 L-3,4-dihydroxyphenylalanine, the immediate precursor of dopamine, can be formed by two enzymes: tyrosine hydroxylase (TH) in catecholamine-producing neurons and chromaffin cells and tyrosinase in melanocytes. Catecholamines 126-139 tyrosine hydroxylase Mus musculus 97-117 12832100-6 2003 Taken together, these results extend the first evidence for a cardiosuppressive role of the N-terminal domain of chromogranin A known for its co-storage with catecholamines in the sympathoadrenal system of vertebrates. Catecholamines 158-172 chromogranin A Bos taurus 113-127 12818374-0 2003 Stimulation of catecholamine synthesis by orexin-A in bovine adrenal medullary cells through orexin receptor 1. Catecholamines 15-28 hypocretin neuropeptide precursor Bos taurus 42-50 12818374-0 2003 Stimulation of catecholamine synthesis by orexin-A in bovine adrenal medullary cells through orexin receptor 1. Catecholamines 15-28 hypocretin receptor 1 Bos taurus 93-110 12818374-2 2003 To determine the role of orexin-A in peripheral metabolic processes, we examined direct effects of orexin-A on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. Catecholamines 111-124 hypocretin neuropeptide precursor Bos taurus 99-107 12818374-4 2003 Orexin-A (100 pM) potentiated the stimulatory effects of acetylcholine (0.3 mM) on 14C-catecholamine synthesis. Catecholamines 87-100 hypocretin neuropeptide precursor Bos taurus 0-8 12818374-9 2003 These findings suggest that orexin-A activates tyrosine hydroxylase and then stimulates catecholamine synthesis, probably via activation of the OX(1)R-protein kinase C pathway in adrenal medullary cells. Catecholamines 88-101 hypocretin neuropeptide precursor Bos taurus 28-36 12890395-1 2003 OBJECTIVE: To study the relationship between pregnancy-induced hypertension (PIH) and catecholamine levels. Catecholamines 86-99 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 77-80 12890395-2 2003 METHODS: Catecholamines levels in maternal and fetal blood were determined in 116 patients with PIH and 40 normal control subjects using high performance liquid chromatography. Catecholamines 9-23 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 96-99 12890395-7 2003 CONCLUSION: The pathogenesis of PIH may relate to catecholamine concentrations in fetus. Catecholamines 50-63 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 32-35 12842306-2 2003 Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine inactivation. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 0-28 12842306-2 2003 Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine inactivation. Catecholamines 61-74 catechol-O-methyltransferase Homo sapiens 30-34 12832289-1 2003 L-3,4-dihydroxyphenylalanine, the immediate precursor of dopamine, can be formed by two enzymes: tyrosine hydroxylase (TH) in catecholamine-producing neurons and chromaffin cells and tyrosinase in melanocytes. Catecholamines 126-139 tyrosine hydroxylase Mus musculus 119-121 12658451-0 2003 Autosomal dominant malignant and catecholamine-producing paraganglioma caused by a splice donor site mutation in SDHC. Catecholamines 33-46 succinate dehydrogenase complex subunit C Homo sapiens 113-117 12865408-6 2003 VDU1, but not VDU2, is markedly increased in brown adipocytes by norepinephrine or cold exposure, further amplifying the increase in D2 activity that results from catecholamine-stimulated de novo synthesis. Catecholamines 163-176 ubiquitin specific peptidase 33 Homo sapiens 0-4 12884403-1 2003 Catechol-O-methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O-methylation of catecholamines and other compounds having a catechol structure. Catecholamines 106-120 catechol-O-methyltransferase Mus musculus 0-28 12884403-1 2003 Catechol-O-methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O-methylation of catecholamines and other compounds having a catechol structure. Catecholamines 106-120 catechol-O-methyltransferase Mus musculus 30-34 12883110-7 2003 Autonomic activity, including blood pressure and circulating levels of catecholamines, increased after administration of the stressor, and correlated with increases of Mac-1. Catecholamines 71-85 integrin subunit alpha M Homo sapiens 168-173 12810852-8 2003 The present data suggest that the high concentration of protons released with ATP (and catecholamines) from secretory vesicles may allow a dual action of H+ on P2X2 receptors. Catecholamines 87-101 purinergic receptor P2X 2 Rattus norvegicus 160-164 12763637-1 2003 Catestatin (bovine CgA(344-364)) is a cationic peptide, which besides reducing catecholamine secretion from chromaffin cells in vitro also acts a potent vasodilator in the rat in vivo. Catecholamines 79-92 chromogranin A Bos taurus 19-22 12795588-1 2003 Catestatin is an active 21-residue peptide derived from the chromogranin A (CgA) precursor, and catestatin is secreted from neuroendocrine chromaffin cells as an autocrine regulator of nicotine-stimulated catecholamine release. Catecholamines 205-218 chromogranin A Homo sapiens 96-106 12795588-9 2003 These findings demonstrate that production of catestatin involves cleavage of CgA at paired basic and monobasic residues, necessary steps for catestatin peptide regulation of nicotinic cholinergic-induced catecholamine release. Catecholamines 205-218 chromogranin A Homo sapiens 46-56 12795588-9 2003 These findings demonstrate that production of catestatin involves cleavage of CgA at paired basic and monobasic residues, necessary steps for catestatin peptide regulation of nicotinic cholinergic-induced catecholamine release. Catecholamines 205-218 chromogranin A Homo sapiens 78-81 12795588-9 2003 These findings demonstrate that production of catestatin involves cleavage of CgA at paired basic and monobasic residues, necessary steps for catestatin peptide regulation of nicotinic cholinergic-induced catecholamine release. Catecholamines 205-218 chromogranin A Homo sapiens 142-152 12574001-0 2003 Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. Catecholamines 0-14 adrenergic receptor, beta 1 Mus musculus 25-49 12574001-7 2003 Isoproterenol, a beta-adrenergic receptor (beta-AR) agonist, reversed this extreme bradycardia, restoring the rate of catecholamine-deficient fetuses to that of nonmutant siblings. Catecholamines 118-131 adrenergic receptor, beta 1 Mus musculus 43-50 12774312-1 2003 Previously we reported that the synthesis of catecholamines, dopamine, and noradrenaline was enhanced by overexpression of V-1 protein, a neuronal protein active in the initial stage of development of the rat cerebellum, in the neuronal cell line PC12D, a model of dopamine cells (Yamakuni et al. Catecholamines 45-59 myotrophin Rattus norvegicus 123-134 12796172-10 2003 Increased cTnT level was the only parameter predicting 15 in-hospital clinical adverse events (ie, death, thrombolysis, cardiopulmonary resuscitation, and IV use of catecholamine agents) [OR, 24.1; 95% CI, 2.9 to 200]. Catecholamines 165-178 troponin T2, cardiac type Homo sapiens 10-14 12788860-6 2003 The low serum leptin level on admission in subjects with hyperglycemic crises may be the result of impaired adipocyte glucose utilization due to insulin deficiency and/or to increased catecholamine levels. Catecholamines 184-197 leptin Homo sapiens 14-20 12763290-1 2003 BACKGROUND: Heat shock protein (HSP) expression can be induced by any stress such as with adrenocorticotropic hormones and catecholamines. Catecholamines 123-137 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 12-30 12763290-1 2003 BACKGROUND: Heat shock protein (HSP) expression can be induced by any stress such as with adrenocorticotropic hormones and catecholamines. Catecholamines 123-137 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 32-35 12765943-11 2003 The induced increments in NE, Epi, and R(a), all of the same magnitude as in IE, strongly support that circulating catecholamines can be the prime regulators of R(a) in IE. Catecholamines 115-129 tissue factor pathway inhibitor Homo sapiens 30-33 12782680-1 2003 Catecholamines and alpha(1)-adrenergic receptors (alpha(1)-ARs) cause cardiac hypertrophy in cultured myocytes and transgenic mice, but heart size is normal in single KOs of the main alpha(1)-AR subtypes, alpha(1A/C) and alpha(1B). Catecholamines 0-14 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mus musculus 205-213 12646581-2 2003 Secretin evokes catecholamine secretion from PC12 pheochromocytoma cells. Catecholamines 16-29 secretin Rattus norvegicus 0-8 12782680-1 2003 Catecholamines and alpha(1)-adrenergic receptors (alpha(1)-ARs) cause cardiac hypertrophy in cultured myocytes and transgenic mice, but heart size is normal in single KOs of the main alpha(1)-AR subtypes, alpha(1A/C) and alpha(1B). Catecholamines 0-14 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 221-229 12730689-3 2003 The reversal of IL-2-mediated hypotension was associated with an increase in plasma catecholamines. Catecholamines 84-98 interleukin 2 Mus musculus 16-20 12704806-9 2003 The present neo(r)-positive TH hypomorphic mice show that nigrostriatal innervation develops independently of TH and should find use as a model for conditions of reduced catecholamine synthesis, as seen in, for example, L-dihydroxyphenylalanine-responsive dystonia/infantile parkinsonism. Catecholamines 170-183 tyrosine hydroxylase Mus musculus 28-30 12787830-13 2003 Our results suggest that inhibition of histamine catabolism using SKF 91488 (histamine N-methyl-transferase inhibitor) resulted in a reduction of histamine-mediated relaxation that was due to the activation of the clobenpropit-sensitive, histamine H(3)/H(4) receptor and the release of catecholamine. Catecholamines 286-299 histamine N-methyltransferase Rattus norvegicus 77-107 12771608-0 2003 Ischemic skin lesions as a complication of continuous vasopressin infusion in catecholamine-resistant vasodilatory shock: incidence and risk factors. Catecholamines 78-91 arginine vasopressin Homo sapiens 54-65 12732600-3 2003 Arginine vasopressin (AVP) has recently been shown to be a potent vasopressor agent to stabilize cardiocirculatory function even in patients with catecholamine-resistant vasodilatory shock. Catecholamines 146-159 arginine vasopressin Homo sapiens 9-20 12732361-8 2003 These results suggest that the beta(2)-AR is the major subtype mediating catecholamine-induced cAMP changes in LNCaP cells. Catecholamines 73-86 adrenoceptor beta 2 Homo sapiens 31-41 12732448-0 2003 A missense mutation in the CASQ2 gene is associated with autosomal-recessive catecholamine-induced polymorphic ventricular tachycardia. Catecholamines 77-90 calsequestrin 2 Homo sapiens 27-32 12916000-13 2003 CONCLUSION: In Type 1 diabetes, impaired diastolic function is associated with elevated ANP and catecholamine plasma levels that are normalized after ACE inhibition. Catecholamines 96-109 angiotensin I converting enzyme Homo sapiens 150-153 12727985-6 2003 Thus, lipolytic catecholamine resistance of sc adipocytes in PCOS is probably attributable to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of PKA, and HSL. Catecholamines 16-29 lipase E, hormone sensitive type Homo sapiens 207-210 12694388-1 2003 Tyrosine hydroxylase (TH) catalyzes the first and rate-limiting step of catecholamine synthesis and its expression is necessary for neurotransmitter specification of all catecholaminergic neurons, while dopamine beta-hydroxylase (DBH) is essential for the noradrenergic phenotype. Catecholamines 72-85 dopamine beta-hydroxylase Homo sapiens 230-233 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-69 catechol-O-methyltransferase Homo sapiens 0-28 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-69 catechol-O-methyltransferase Homo sapiens 30-34 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-68 catechol-O-methyltransferase Homo sapiens 0-28 12739038-2 2003 Catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines and catecholamine-containing drugs. Catecholamines 55-68 catechol-O-methyltransferase Homo sapiens 30-34 12697718-1 2003 Angiotensin II (Ang II) AT(1) receptors have been proposed to mediate the Ang II-dependent and the stress-stimulated adrenomedullary catecholamine synthesis and release. Catecholamines 133-146 angiotensinogen Rattus norvegicus 0-14 12697718-1 2003 Angiotensin II (Ang II) AT(1) receptors have been proposed to mediate the Ang II-dependent and the stress-stimulated adrenomedullary catecholamine synthesis and release. Catecholamines 133-146 angiotensinogen Rattus norvegicus 16-22 12719770-5 2003 We recently demonstrated immunohistochemically that a single injection of either a natural or synthetic catecholamine induces both cardiomyocyte apoptosis (identified by an anti-caspase 3 antibody) and necrosis (identified by an anti-myosin antibody) in the rat heart in vivo. Catecholamines 104-117 caspase 3 Rattus norvegicus 178-187 12668588-0 2003 Hypotension and reduced catecholamines in neuropeptide Y transgenic rats. Catecholamines 24-38 neuropeptide Y Rattus norvegicus 42-56 12668588-4 2003 This study tested a hypothesis that endogenous neuropeptide Y acts to reduce blood pressure and catecholamine release. Catecholamines 96-109 neuropeptide Y Rattus norvegicus 47-61 12684698-6 2003 These puzzling findings are interpreted in light of the fact that i) our cultures were actually a mixture of ZG, ZF/R and medullary chromaffin cells; ii) ADM stimulates adrenomedullary cells to release catecholamines, which are able to enhance aldosterone secretion from ZG cells; and iii) the prolonged exposure to ADM may modify, under in vitro culture conditions, ZF/R cells, switching their phenotype from an ADM-unresponsive to an ADM-responsive one. Catecholamines 202-216 adrenomedullin Rattus norvegicus 154-157 12684698-6 2003 These puzzling findings are interpreted in light of the fact that i) our cultures were actually a mixture of ZG, ZF/R and medullary chromaffin cells; ii) ADM stimulates adrenomedullary cells to release catecholamines, which are able to enhance aldosterone secretion from ZG cells; and iii) the prolonged exposure to ADM may modify, under in vitro culture conditions, ZF/R cells, switching their phenotype from an ADM-unresponsive to an ADM-responsive one. Catecholamines 202-216 adrenomedullin Rattus norvegicus 316-319 12684698-6 2003 These puzzling findings are interpreted in light of the fact that i) our cultures were actually a mixture of ZG, ZF/R and medullary chromaffin cells; ii) ADM stimulates adrenomedullary cells to release catecholamines, which are able to enhance aldosterone secretion from ZG cells; and iii) the prolonged exposure to ADM may modify, under in vitro culture conditions, ZF/R cells, switching their phenotype from an ADM-unresponsive to an ADM-responsive one. Catecholamines 202-216 adrenomedullin Rattus norvegicus 316-319 12684698-6 2003 These puzzling findings are interpreted in light of the fact that i) our cultures were actually a mixture of ZG, ZF/R and medullary chromaffin cells; ii) ADM stimulates adrenomedullary cells to release catecholamines, which are able to enhance aldosterone secretion from ZG cells; and iii) the prolonged exposure to ADM may modify, under in vitro culture conditions, ZF/R cells, switching their phenotype from an ADM-unresponsive to an ADM-responsive one. Catecholamines 202-216 adrenomedullin Rattus norvegicus 316-319 12750401-6 2003 Pulmonary expression levels of endothelin-1 and plasma catecholamine levels were increased threefold and 12-fold respectively in WT but not in Hif2alpha(+/-) mice after hypoxia, suggesting that HIF-2alpha-mediated upregulation of these vasoconstrictors contributes to the development of hypoxic pulmonary vascular remodeling. Catecholamines 55-68 endothelial PAS domain protein 1 Mus musculus 194-204 12694379-1 2003 We investigated the role played by catecholamine-dependent pathways in modulating the ability of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) to release adrenocorticotropic hormone (ACTH) following its intracerebroventricular (i.c.v.) Catecholamines 35-48 MAPK associated protein 1 Homo sapiens 151-156 12694379-1 2003 We investigated the role played by catecholamine-dependent pathways in modulating the ability of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) to release adrenocorticotropic hormone (ACTH) following its intracerebroventricular (i.c.v.) Catecholamines 35-48 proopiomelanocortin Homo sapiens 169-196 12694379-14 2003 Our laboratory and others have previously reported that NO increased hypothalamic noradrenaline levels, while conversely noradrenaline up-regulated levels of NO synthase, the enzyme responsible for NO formation; and that injection of corticotropin-releasing factor into the brain ventricles releases catecholamines and stimulates NO formation. Catecholamines 300-314 corticotropin releasing hormone Homo sapiens 234-264 12694388-1 2003 Tyrosine hydroxylase (TH) catalyzes the first and rate-limiting step of catecholamine synthesis and its expression is necessary for neurotransmitter specification of all catecholaminergic neurons, while dopamine beta-hydroxylase (DBH) is essential for the noradrenergic phenotype. Catecholamines 72-85 tyrosine hydroxylase Homo sapiens 0-20 12694388-1 2003 Tyrosine hydroxylase (TH) catalyzes the first and rate-limiting step of catecholamine synthesis and its expression is necessary for neurotransmitter specification of all catecholaminergic neurons, while dopamine beta-hydroxylase (DBH) is essential for the noradrenergic phenotype. Catecholamines 72-85 tyrosine hydroxylase Homo sapiens 22-24 12694388-1 2003 Tyrosine hydroxylase (TH) catalyzes the first and rate-limiting step of catecholamine synthesis and its expression is necessary for neurotransmitter specification of all catecholaminergic neurons, while dopamine beta-hydroxylase (DBH) is essential for the noradrenergic phenotype. Catecholamines 72-85 dopamine beta-hydroxylase Homo sapiens 203-228 12675917-2 2003 The external Ca2+-dependent K+-induced [3H]catecholamine overflows were almost totally abolished by botulinum toxin C1 (BoNT/C1), which hydrolyses syntaxin and SNAP-25, or by botulinum toxin E (BoNT/E), selective for SNAP-25. Catecholamines 43-56 synaptosome associated protein 25 Rattus norvegicus 160-167 12670699-9 2003 Together, these data imply that alpha(2A)- and alpha(2C)-adrenoceptors are located on different neurons in the striatum, that alpha(2C)-adrenoceptor-mediated effects on striatal GABA release are mediated by an endogenous catecholamine that could be dopamine, and that the alpha(2C)-adrenoceptor effect of RX821002 does not occur at the GABAergic terminal. Catecholamines 221-234 adrenergic receptor, alpha 2c Mus musculus 126-148 12531732-2 2003 In the present study, we investigated the role of the catecholamine-degrading enzyme monoamine oxidase (MAO) in H(2)O(2) production in the hearts of young, adult, and old rats. Catecholamines 54-67 monoamine oxidase A Rattus norvegicus 104-107 17021455-3 2003 RECENT FINDINGS: Several retrospective investigations give evidence that vasopressin at a dosage of 2-6 U/h is effective in reversing catecholamine-resistant vasodilatory shock due to sepsis or after cardiopulmonary bypass, but prospective randomized controlled trials are warranted. Catecholamines 134-147 arginine vasopressin Homo sapiens 73-84 12706246-3 2003 Using dual immunofluorescent labelling on adjacent cryostat sections, we investigated the presence of immunoreactivity for the GABA(B)R1 and GABA(B)R2 subunits in brainstem catecholamine (tyrosine hydroxylase-immunoreactive) and serotonin (tryptophan hydroxylase-immunoreactive) neurons. Catecholamines 173-186 gamma-aminobutyric acid (GABA) B receptor, 1 Mus musculus 127-136 12706246-3 2003 Using dual immunofluorescent labelling on adjacent cryostat sections, we investigated the presence of immunoreactivity for the GABA(B)R1 and GABA(B)R2 subunits in brainstem catecholamine (tyrosine hydroxylase-immunoreactive) and serotonin (tryptophan hydroxylase-immunoreactive) neurons. Catecholamines 173-186 gamma-aminobutyric acid (GABA) B receptor, 2 Mus musculus 141-150 12706246-4 2003 All neurons (>98%) examined in catecholamine groups A1, A2, A5, A6, C1, and serotonin groups B1-3 and B6-8 were immunoreactive for the GABA(B)R1 subunit. Catecholamines 34-47 gamma-aminobutyric acid (GABA) B receptor, 1 Mus musculus 138-147 12706246-8 2003 In general, our results suggest that GABA(B)R1 and GABA(B)R2 co-exist in the great majority of brainstem catecholamine and serotonin neurons. Catecholamines 105-118 gamma-aminobutyric acid (GABA) B receptor, 1 Mus musculus 37-46 12706246-8 2003 In general, our results suggest that GABA(B)R1 and GABA(B)R2 co-exist in the great majority of brainstem catecholamine and serotonin neurons. Catecholamines 105-118 gamma-aminobutyric acid (GABA) B receptor, 2 Mus musculus 51-60 12778363-2 2003 White adipocytes are capable of producing vascular endothelial growth factor (VEGF) in response to insulin and catecholamines. Catecholamines 111-125 vascular endothelial growth factor A Rattus norvegicus 42-76 12778363-2 2003 White adipocytes are capable of producing vascular endothelial growth factor (VEGF) in response to insulin and catecholamines. Catecholamines 111-125 vascular endothelial growth factor A Rattus norvegicus 78-82 12684481-0 2003 Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. Catecholamines 35-48 glucagon Rattus norvegicus 0-23 12684481-0 2003 Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. Catecholamines 35-48 glucagon Rattus norvegicus 94-117 12684481-11 2003 These findings suggest that catecholamine neurons in the AP link peripheral GLP-1 and central autonomic control sites that mediate the diverse neuroendocrine and autonomic actions of peripheral GLP-1. Catecholamines 28-41 glucagon Rattus norvegicus 76-81 12675917-2 2003 The external Ca2+-dependent K+-induced [3H]catecholamine overflows were almost totally abolished by botulinum toxin C1 (BoNT/C1), which hydrolyses syntaxin and SNAP-25, or by botulinum toxin E (BoNT/E), selective for SNAP-25. Catecholamines 43-56 synaptosome associated protein 25 Rattus norvegicus 217-224 12684481-11 2003 These findings suggest that catecholamine neurons in the AP link peripheral GLP-1 and central autonomic control sites that mediate the diverse neuroendocrine and autonomic actions of peripheral GLP-1. Catecholamines 28-41 glucagon Rattus norvegicus 194-199 12571119-1 2003 In the mammalian neocortex, neurons containing tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, constitute an enigmatic and ill-defined group of aspiny non-pyramidal cells. Catecholamines 102-115 tyrosine hydroxylase Homo sapiens 47-67 12609750-0 2003 Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adrenal chromaffin cells through the AT1 receptor. Catecholamines 24-37 angiotensinogen Homo sapiens 0-14 12609750-1 2003 The aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Catecholamines 82-96 angiotensinogen Homo sapiens 55-69 12609750-1 2003 The aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Catecholamines 82-96 angiotensinogen Homo sapiens 71-77 12645718-3 2003 In patients receiving ACE inhibition, we investigated whether initiation of vasopressin before CPB would diminish post-CPB hypotension and catecholamine use by avoiding vasopressin deficiency. Catecholamines 139-152 arginine vasopressin Homo sapiens 76-87 12645718-6 2003 After CPB, the vasopressin group had a lower peak norepinephrine dose than the placebo group (4.6 +/- 2.5 versus 7.3 +/- 3.5 microg/min, p = 0.03), a shorter period on catecholamines (5 +/- 6 versus 11 +/- 7 hours, p = 0.03), fewer hypotensive episodes (1 +/- 1 versus 4 +/- 2, p < 0.01), and a shorter intensive care unit length of stay (1.2 +/- 0.4 versus 2.1 +/- 1.4 days, p = 0.03). Catecholamines 168-182 arginine vasopressin Homo sapiens 15-26 12571119-1 2003 In the mammalian neocortex, neurons containing tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, constitute an enigmatic and ill-defined group of aspiny non-pyramidal cells. Catecholamines 102-115 tyrosine hydroxylase Homo sapiens 69-71 12620376-10 2003 The results suggest that catecholamines have a synergic effect on LPS in induction of iNOS synthesis and NO production, and this may mediate some of the vascular effects of infection. Catecholamines 25-39 nitric oxide synthase 2, inducible Mus musculus 86-90 14561173-8 2003 Additionally, catecholamines drive humoral immunity by stimulating macrophage IL-10 production. Catecholamines 14-28 interleukin 10 Homo sapiens 78-83 14561173-9 2003 These catecholamine effects are mediated largely via beta(2)-AR activation. Catecholamines 6-19 adrenoceptor beta 2 Homo sapiens 53-63 12621527-9 2003 These findings provide evidence that catecholamines are involved in mechanisms that rapidly alter the expression of the genes of the renin-angiotensin system within the kidney. Catecholamines 37-51 renin Rattus norvegicus 133-138 12618232-0 2003 Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Catecholamines 90-103 mitogen-activated protein kinase 14 Mus musculus 27-30 12618232-1 2003 OBJECTIVE: Exogenous catecholamine exposure has been associated with p38 mitogen-activated protein kinase (MAPK) and cardiac hypertrophy. Catecholamines 21-34 mitogen-activated protein kinase 14 Mus musculus 69-72 12631267-8 2003 Two alternative conformations, rotated 180 degrees around an imaginary iron-catecholamine axis, were found for DA and l-DOPA in PAH and for DA in TH. Catecholamines 76-89 phenylalanine hydroxylase Homo sapiens 128-131 12631267-8 2003 Two alternative conformations, rotated 180 degrees around an imaginary iron-catecholamine axis, were found for DA and l-DOPA in PAH and for DA in TH. Catecholamines 76-89 tyrosine hydroxylase Homo sapiens 146-148 12578963-5 2003 In 17 of 19 volunteers, NF-kappaB was rapidly induced during stress exposure, in parallel with elevated levels of catecholamines and cortisol, and returned to basal levels within 60 min. Catecholamines 114-128 nuclear factor kappa B subunit 1 Homo sapiens 24-33 12629174-0 2003 A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. Catecholamines 112-125 syntaxin 1A Homo sapiens 27-38 12629174-0 2003 A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. Catecholamines 112-125 solute carrier family 6 member 2 Homo sapiens 73-99 12573802-0 2003 Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis. Catecholamines 125-138 adenylate cyclase activating polypeptide 1 Homo sapiens 23-28 12573802-1 2003 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagons/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 168-181 adenylate cyclase activating polypeptide 1 Homo sapiens 9-59 12573802-1 2003 PURPOSE: Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagons/vasoactive intestinal peptide family, induces the expression of catecholamine-synthesizing enzymes in adrenal medullary cells. Catecholamines 168-181 adenylate cyclase activating polypeptide 1 Homo sapiens 61-66 12573802-2 2003 In addition, PACAP and its receptor have been detected in human pheochromocytoma tissues, though it is not yet known whether PACAP enhances the expression of genes encoding catecholamine-synthesizing enzymes. Catecholamines 173-186 adenylate cyclase activating polypeptide 1 Homo sapiens 125-130 12573802-7 2003 CONCLUSION: Our findings support a possible role for PACAP in the regulation of expression of genes encoding catecholamine-synthesizing enzymes in intra-adrenal pheochromocytomas. Catecholamines 109-122 adenylate cyclase activating polypeptide 1 Homo sapiens 53-58 12493739-2 2003 Recently, we provided evidence that stress-induced IL-10 promoter activation in monocytic cells is mediated by catecholamines via a cAMP-dependent signaling pathway including CREB/ATF (cAMP-responsive element binding protein/activating transcription factor) binding to two CRE motifs. Catecholamines 111-125 interleukin 10 Homo sapiens 51-56 12493739-2 2003 Recently, we provided evidence that stress-induced IL-10 promoter activation in monocytic cells is mediated by catecholamines via a cAMP-dependent signaling pathway including CREB/ATF (cAMP-responsive element binding protein/activating transcription factor) binding to two CRE motifs. Catecholamines 111-125 cAMP responsive element binding protein 1 Homo sapiens 175-179 12493739-2 2003 Recently, we provided evidence that stress-induced IL-10 promoter activation in monocytic cells is mediated by catecholamines via a cAMP-dependent signaling pathway including CREB/ATF (cAMP-responsive element binding protein/activating transcription factor) binding to two CRE motifs. Catecholamines 111-125 glial cell derived neurotrophic factor Homo sapiens 180-183 12678500-3 2003 PEC-60-like immunoreactive material has been reported in catecholamine neurons of the central and peripheral nervous systems, but the peptide has not been identified from that material. Catecholamines 57-70 serine peptidase inhibitor Kazal type 4 Sus scrofa 0-6 12546688-8 2003 Furthermore, AMPK alpha 2(-/-) mice have a higher sympathetic tone, as shown by increased catecholamine urinary excretion. Catecholamines 90-103 protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus 13-25 12668869-10 2003 Pretreatment with the catecholamine synthesis inhibitor, alpha-methyl-para-tyrosine, prevented the stimulation of PRL secretion observed following central administration of RFRP-1. Catecholamines 22-35 prolactin Rattus norvegicus 114-117 12665315-0 2003 Effect of Ghrelin on catecholamine secretion in rat pheochromocytoma PC12 cells. Catecholamines 21-34 ghrelin and obestatin prepropeptide Rattus norvegicus 10-17 12665315-3 2003 At concentrations of 10 nM and over (10 nM, 100 nM, and 1 microM), ghrelin significantly inhibited basal dopamine release by 30, 32 and 34%, respectively (P < 0.05) in PC12 cells, suggesting that ghrelin may be involved in the mechanism of catecholamine regulation in chromaffin cells. Catecholamines 243-256 ghrelin and obestatin prepropeptide Rattus norvegicus 67-74 12668879-8 2003 Qualitatively, catecholamine fluorescence in A12 perikarya and terminals in df/df mice was enhanced by PRL treatment initiated at 12 or 21, but not at 30, d of age. Catecholamines 15-28 prolactin Mus musculus 103-106 12429744-2 2003 The aim of the present study was to identify PACAP receptor isoforms and to determine whether PACAP can affect intracellular calcium concentration ([Ca(2+)](i)) and catecholamine secretion. Catecholamines 165-178 adenylate cyclase activating polypeptide 1 Homo sapiens 94-99 12538816-4 2003 The modulatory effect of these catecholamines on ICAM-1 expression was antagonized by beta 2-AR antagonist, but not by alpha 1-, alpha 2-, or beta 1-AR antagonist. Catecholamines 31-45 intercellular adhesion molecule 1 Homo sapiens 49-55 12538816-4 2003 The modulatory effect of these catecholamines on ICAM-1 expression was antagonized by beta 2-AR antagonist, but not by alpha 1-, alpha 2-, or beta 1-AR antagonist. Catecholamines 31-45 adrenoceptor beta 2 Homo sapiens 86-95 12606256-1 2003 We studied cardiac outward K currents (transient and sustained) by the whole-cell patch-clamp technique and the Kv4.2, Kv4.3, Kv1.4, Kv1.5, Kv1.2 and Kv2.1 expression of voltage-gated K channel by RT-PCR, in ventricular myocytes from two models of catecholamine-depleted adult rats. Catecholamines 248-261 potassium voltage-gated channel subfamily B member 1 Rattus norvegicus 150-155 12429744-9 2003 Moreover, PACAP induced catecholamine secretion by chromaffin cells. Catecholamines 24-37 adenylate cyclase activating polypeptide 1 Homo sapiens 10-15 12388421-1 2003 In the present study, we investigated the existence of a back-regulation of the catecholamine-degrading enzyme monoamine oxidase (MAO)-A by dopamine in rat renal cells. Catecholamines 80-93 monoamine oxidase A Rattus norvegicus 111-136 12429744-10 2003 It is concluded that PACAP-38, through the PAC(1) receptor, acts as a neurotransmitter in human fetal chromaffin cells inducing catecholamine secretion, through nonclassical, recently described, ryanodine/caffeine-sensitive pools, involving a cAMP- and PKA-dependent phosphorylation mechanism. Catecholamines 128-141 adenylate cyclase activating polypeptide 1 Homo sapiens 21-26 12401811-7 2003 Moreover, infusion of isoproterenol resulted in PKA phosphorylation of RyR2 in rat, indicating that systemic catecholamines can activate phosphorylation of RyR2 in vivo. Catecholamines 109-123 ryanodine receptor 2 Rattus norvegicus 71-75 12401811-7 2003 Moreover, infusion of isoproterenol resulted in PKA phosphorylation of RyR2 in rat, indicating that systemic catecholamines can activate phosphorylation of RyR2 in vivo. Catecholamines 109-123 ryanodine receptor 2 Rattus norvegicus 156-160 12784927-0 2003 Effects of infusion of corticotropin-releasing factor antagonist into the locus coeruleus on freezing behavior and brain catecholamines in rats. Catecholamines 121-135 corticotropin releasing hormone Rattus norvegicus 23-53 12388268-7 2003 These data support the novel hypothesis that a direct alpha(1A)-adrenoceptor-dependent trophic action of catecholamines is augmented by injury and may contribute significantly to hypertrophic vascular disease. Catecholamines 105-119 adrenoceptor alpha 1A Rattus norvegicus 54-76 12535832-11 2003 CONCLUSIONS: These results suggest that by blocking the beta(2)-stimulating effects of catecholamines, carvedilol exerts some of its beneficial effects by increasing the production of IL-12 and IFN-gamma. Catecholamines 87-101 interferon gamma Homo sapiens 194-203 12534330-3 2003 We report on physiological and pharmacological aspects of arginine vasopressin, and summarise current clinical knowledge on employing a continuous arginine vasopressin infusion in critically ill patients with catecholamine-resistant vasodilatory shock of different aetiologies. Catecholamines 209-222 arginine vasopressin Homo sapiens 156-167 12891655-1 2003 Tyrosine hydroxylase (TH) is the key enzyme in the biosynthesis of the catecholamines dopamine, epinephrine, and norepinephrine. Catecholamines 71-85 tyrosine hydroxylase Homo sapiens 0-20 12891655-1 2003 Tyrosine hydroxylase (TH) is the key enzyme in the biosynthesis of the catecholamines dopamine, epinephrine, and norepinephrine. Catecholamines 71-85 tyrosine hydroxylase Homo sapiens 22-24 12511144-12 2003 Despite significantly more fluid and catecholamine administration in the TNF group, the mean arterial pressure and the systemic vascular resistance index were significantly (P<.001) lower than in the non-TNF group. Catecholamines 37-50 tumor necrosis factor Homo sapiens 73-76 12582999-6 2003 The evaluation of the catecholamines oxidation profile was performed by HPLC with photodiode array detection and using either enzymatic (tyrosinase) or non-enzymatic [Ag(2)O, CuSO(4), NaIO(4) and K(3)Fe(CN)(6)] catalytic systems. Catecholamines 22-36 tyrosinase Rattus norvegicus 137-147 12534330-5 2003 Because data on adverse effects are still limited, arginine vasopressin should be reserved for patients in whom adequate haemodynamic stabilisation cannot be achieved with conventional vasopressor therapy or who have obvious adverse effects of catecholamines that result in further significant haemodynamic deterioration. Catecholamines 244-258 arginine vasopressin Homo sapiens 60-71 12511592-9 2003 Concordantly, we found an increased daily urinary catecholamine excretion in AMPKalpha2(-/-) mice, suggesting altered function of the autonomic nervous system that could explain both the impaired insulin secretion and insulin sensitivity observed in vivo. Catecholamines 50-63 protein kinase, AMP-activated, alpha 2 catalytic subunit Mus musculus 77-87 12534973-3 2003 We studied the alterations in tyrosine hydroxylase (TH; the rate-limiting enzyme in catecholamines biosynthesis) immunoreactivity levels and TH enzyme activity in the rat NTS-A2/VLM-A1 noradrenergic cell groups and in the PVN during morphine withdrawal. Catecholamines 84-98 tyrosine hydroxylase Rattus norvegicus 30-50 12534973-3 2003 We studied the alterations in tyrosine hydroxylase (TH; the rate-limiting enzyme in catecholamines biosynthesis) immunoreactivity levels and TH enzyme activity in the rat NTS-A2/VLM-A1 noradrenergic cell groups and in the PVN during morphine withdrawal. Catecholamines 84-98 tyrosine hydroxylase Rattus norvegicus 52-54 12488332-4 2003 Here we determine the role of hindbrain catecholamine afferents in glucoprivation-induced increase in ARC NPY and AGRP gene expression. Catecholamines 40-53 agouti related neuropeptide Homo sapiens 114-118 12502754-6 2003 ISH histochemistry revealed strong expression of sstr2 mRNA alone localized to the zona glomerulosa of the adrenal cortex and moderate labeling in scattered cells of the adrenal medulla, indicating a possible role for sstr2 in mediating SRIF physiology in this tissue by altering adrenal aldosterone and catecholamine secretion. Catecholamines 304-317 somatostatin receptor 2 Rattus norvegicus 49-54 12509479-3 2003 Under stimulation with catecholamines, eNOS-/- mice predominantly show a potentiation in their beta-adrenergic inotropic and lusitropic responsiveness. Catecholamines 23-37 nitric oxide synthase 3, endothelial cell Mus musculus 39-43 12768439-1 2003 The extraneuronal monoamine transporter EMT (HGNC Nomenclature SLC22A3) is the molecular correlate of the classical uptake(2) system responsible for the non-neuronal inactivation of circulating and centrally released catecholamines. Catecholamines 217-231 IL2 inducible T cell kinase Homo sapiens 40-43 12768439-1 2003 The extraneuronal monoamine transporter EMT (HGNC Nomenclature SLC22A3) is the molecular correlate of the classical uptake(2) system responsible for the non-neuronal inactivation of circulating and centrally released catecholamines. Catecholamines 217-231 solute carrier family 22 member 3 Homo sapiens 63-70 12450763-2 2003 This paper proposes that post-prandial insulin resistance, in association with raised levels of cortisol and catecholamines, plays the major role, and may even be the primary causative factor. Catecholamines 109-123 insulin Homo sapiens 39-46 14673217-1 2003 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines, including levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 0-28 12738901-11 2003 The synthesis of endothelin-1 is induced by hypoxia, thrombin, interleukin-1, transforming growth factor-beta1, vasopressin, and catecholamines. Catecholamines 129-143 endothelin 1 Homo sapiens 17-29 12535946-1 2003 Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines, including the neurotransmitter dopamine. Catecholamines 71-85 catechol-O-methyltransferase Homo sapiens 0-28 12535946-1 2003 Catechol O-methyltransferase (COMT) is involved in the inactivation of catecholamines, including the neurotransmitter dopamine. Catecholamines 71-85 catechol-O-methyltransferase Homo sapiens 30-34 12528876-9 2003 CONCLUSIONS: Beat-to-beat nonalternating T-wave lability occurs in LQT1, LQT2, and LQT3 patients during catecholamine provocation and is associated with a history of prior cardiac events. Catecholamines 104-117 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 67-71 12528876-9 2003 CONCLUSIONS: Beat-to-beat nonalternating T-wave lability occurs in LQT1, LQT2, and LQT3 patients during catecholamine provocation and is associated with a history of prior cardiac events. Catecholamines 104-117 potassium voltage-gated channel subfamily H member 2 Homo sapiens 73-77 12528876-9 2003 CONCLUSIONS: Beat-to-beat nonalternating T-wave lability occurs in LQT1, LQT2, and LQT3 patients during catecholamine provocation and is associated with a history of prior cardiac events. Catecholamines 104-117 sodium voltage-gated channel alpha subunit 5 Homo sapiens 83-87 14673217-1 2003 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines, including levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 30-34 12835121-8 2003 Since tyrosinase also possesses catecholamine-synthesizing activity in the absence of tyrosine hydroxylase (TH), the double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopaminergic neurons, and in the normalization of abnormal DA turnover in the long-term L-DOPA-treated Parkinson"s disease patients. Catecholamines 32-45 tyrosinase Homo sapiens 6-16 12835121-8 2003 Since tyrosinase also possesses catecholamine-synthesizing activity in the absence of tyrosine hydroxylase (TH), the double-edged synthesizing and oxidizing functions of tyrosinase in the dopaminergic system suggest its potential for application in the synthesis of DA, instead of TH in the degeneration of dopaminergic neurons, and in the normalization of abnormal DA turnover in the long-term L-DOPA-treated Parkinson"s disease patients. Catecholamines 32-45 tyrosinase Homo sapiens 170-180 12688826-10 2003 Analogous changes can be induced by other forms of stress that release catecholamines or by catecholamine infusion, and responses are blocked by beta(2)-blocking agents. Catecholamines 71-85 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 145-151 12688826-10 2003 Analogous changes can be induced by other forms of stress that release catecholamines or by catecholamine infusion, and responses are blocked by beta(2)-blocking agents. Catecholamines 71-84 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 145-151 12460640-4 2002 The vasopressin (0.2 nmol/animal)-induced elevation of both catecholamines was significantly attenuated by [d(CH(2))(5)(1),Tyr(Me)(2),Arg(8)]-vasopressin, a selective vasopressin V(1) receptor antagonist, in a dose-dependent manner (0.1 and 0.2 nmol/animal, i.c.v.). Catecholamines 60-74 arginine vasopressin Rattus norvegicus 4-15 12373741-2 2002 Activity in this circuit is crucially modulated by catecholamines and agonists of the alpha-2A-adrenergic receptor (alpha(2A)-AR), which relieve cardiovascular and gastrointestinal symptoms associated with experience of aversive stimuli. Catecholamines 51-65 adrenoceptor alpha 2A Rattus norvegicus 86-114 12373741-2 2002 Activity in this circuit is crucially modulated by catecholamines and agonists of the alpha-2A-adrenergic receptor (alpha(2A)-AR), which relieve cardiovascular and gastrointestinal symptoms associated with experience of aversive stimuli. Catecholamines 51-65 adrenoceptor alpha 2A Rattus norvegicus 116-128 12460640-4 2002 The vasopressin (0.2 nmol/animal)-induced elevation of both catecholamines was significantly attenuated by [d(CH(2))(5)(1),Tyr(Me)(2),Arg(8)]-vasopressin, a selective vasopressin V(1) receptor antagonist, in a dose-dependent manner (0.1 and 0.2 nmol/animal, i.c.v.). Catecholamines 60-74 arginine vasopressin Rattus norvegicus 142-153 12460640-4 2002 The vasopressin (0.2 nmol/animal)-induced elevation of both catecholamines was significantly attenuated by [d(CH(2))(5)(1),Tyr(Me)(2),Arg(8)]-vasopressin, a selective vasopressin V(1) receptor antagonist, in a dose-dependent manner (0.1 and 0.2 nmol/animal, i.c.v.). Catecholamines 60-74 arginine vasopressin Rattus norvegicus 142-153 12460640-10 2002 The vasopressin-induced elevation of catecholamines was abolished by indomethacin, an inhibitor of cyclooxygenase (1.2 micromol/animal, i.c.v.). Catecholamines 37-51 arginine vasopressin Rattus norvegicus 4-15 12436243-1 2002 Catechol-O-methyl transferase (COMT) catalyzes the first step in one of the major pathways in the degradation of catecholamines. Catecholamines 113-127 catechol-O-methyltransferase Homo sapiens 0-29 12457228-1 2002 Using immunocytochemistry coupled to fluorescence and electron microscopy, we investigated the expression and ultrastructural localization of tyrosine hydroxylase (TH, EC 1.14.16.2), the rate-limiting enzyme in the biosynthesis of catecholamines, in human peripheral blood mononuclear cells (PBMCs), with PC12 cells as positive controls. Catecholamines 231-245 tyrosine hydroxylase Homo sapiens 142-162 12457228-1 2002 Using immunocytochemistry coupled to fluorescence and electron microscopy, we investigated the expression and ultrastructural localization of tyrosine hydroxylase (TH, EC 1.14.16.2), the rate-limiting enzyme in the biosynthesis of catecholamines, in human peripheral blood mononuclear cells (PBMCs), with PC12 cells as positive controls. Catecholamines 231-245 tyrosine hydroxylase Homo sapiens 164-166 12420309-0 2002 Catecholamine-induced oligodendrocyte cell death in culture is developmentally regulated and involves free radical generation and differential activation of caspase-3. Catecholamines 0-13 caspase 3 Homo sapiens 157-166 12420309-4 2002 Catecholamines caused a reduction in intracellular glutathione levels, an accumulation in reactive oxygen species and in heme oxygenase-1, the 32 kDa stress-induced protein. Catecholamines 0-14 heme oxygenase 1 Homo sapiens 121-137 12420309-4 2002 Catecholamines caused a reduction in intracellular glutathione levels, an accumulation in reactive oxygen species and in heme oxygenase-1, the 32 kDa stress-induced protein. Catecholamines 0-14 tumor protein p53 inducible nuclear protein 1 Homo sapiens 150-172 12402217-2 2002 One of these is its biochemical function in metabolism of catecholamine neurotransmitters; another is the microdeletion, on chromosome 22q11, that includes the COMT gene and causes velocardiofacial syndrome, a syndrome associated with a high rate of psychosis, particularly schizophrenia. Catecholamines 58-71 catechol-O-methyltransferase Homo sapiens 160-164 12436243-1 2002 Catechol-O-methyl transferase (COMT) catalyzes the first step in one of the major pathways in the degradation of catecholamines. Catecholamines 113-127 catechol-O-methyltransferase Homo sapiens 31-35 12218046-2 2002 Catecholamines stimulate adipocyte lipolysis through reversible phosphorylation of hormone-sensitive lipase, and simultaneously inhibit LPL activity. Catecholamines 0-14 lipoprotein lipase Homo sapiens 136-139 12473075-7 2002 In response to severe hypoxia, free-tissue catecholamine increased to 4.92 +/- 0.85 microm in wild-type mice and 4.26 +/- 0.63 microm in NK1-KO mice, which were also not significantly different. Catecholamines 43-56 tachykinin 1 Mus musculus 137-140 12438556-1 2002 Two different uptake processes terminate the synaptic action of released catecholamines in brain: the high-affinity uptake to presynaptic nerve terminals (uptake(1), followed by oxidation by monoamine oxidase, MAO) or glial cells uptake (uptake(2), followed by O-methylation by catechol-O-methyltransferase, COMT, and/or oxidation by MAO). Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 278-306 12438556-1 2002 Two different uptake processes terminate the synaptic action of released catecholamines in brain: the high-affinity uptake to presynaptic nerve terminals (uptake(1), followed by oxidation by monoamine oxidase, MAO) or glial cells uptake (uptake(2), followed by O-methylation by catechol-O-methyltransferase, COMT, and/or oxidation by MAO). Catecholamines 73-87 catechol-O-methyltransferase Homo sapiens 308-312 12458065-3 2002 Catecholamine levels correlate with injury severity scores and changes of L-selectin expression on leucocytes, whilst adrenaline (ADR) (epinephrine) alone also activates platelets. Catecholamines 0-13 selectin L Homo sapiens 74-84 12475383-10 2002 As SOCS-3 is a novel inhibitor of insulin signaling, the data support a possible role of this protein as a selectively regulated mediator of catecholamine-induced insulin resistance. Catecholamines 141-154 suppressor of cytokine signaling 3 Mus musculus 3-9 12446807-1 2002 The alpha 2B adrenergic receptor (A2AB) is a heptahelical G protein-coupled receptor for catecholamines. Catecholamines 89-103 adrenoceptor alpha 2B Homo sapiens 4-32 12527477-0 2002 The age-related discrepancy in the effect of neuropeptide Y on select catecholamine biosynthetic enzymes in the adrenal medulla and hypothalamus in rats. Catecholamines 70-83 neuropeptide Y Rattus norvegicus 45-59 12527477-1 2002 The elevated levels of circulating catecholamines (CAs) with age may be related to the increased expression of CA biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the adrenal medulla of senescent compared with younger animals. Catecholamines 35-49 tyrosine hydroxylase Rattus norvegicus 136-156 12527477-1 2002 The elevated levels of circulating catecholamines (CAs) with age may be related to the increased expression of CA biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the adrenal medulla of senescent compared with younger animals. Catecholamines 35-49 tyrosine hydroxylase Rattus norvegicus 158-160 12527477-1 2002 The elevated levels of circulating catecholamines (CAs) with age may be related to the increased expression of CA biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the adrenal medulla of senescent compared with younger animals. Catecholamines 35-49 dopamine beta-hydroxylase Rattus norvegicus 166-191 12527477-2 2002 Neuropeptide Y (NPY) is co-synthesized and co-released with CAs in the adrenal medulla. Catecholamines 60-63 neuropeptide Y Rattus norvegicus 0-14 12527477-2 2002 Neuropeptide Y (NPY) is co-synthesized and co-released with CAs in the adrenal medulla. Catecholamines 60-63 neuropeptide Y Rattus norvegicus 16-19 12527477-3 2002 NPY inhibits the stimulated secretion of CAs, however, its role in regulation of the genes encoding CA biosynthetic enzymes is not clear. Catecholamines 41-44 neuropeptide Y Rattus norvegicus 0-3 12417548-6 2002 Excess mortality in alpha2A- and alpha2C-KO strains was attributable to heart failure with enhanced left ventricular hypertrophy and fibrosis and elevated circulating catecholamines. Catecholamines 167-181 adrenergic receptor, alpha 2a Mus musculus 20-27 12139486-2 2002 Regulation of ApN by catecholamines has scarcely been investigated. Catecholamines 21-35 adiponectin, C1Q and collagen domain containing Mus musculus 14-17 12564841-1 2002 BACKGROUND: Catechol-O-methyltransferase (COMT) catalyses the inactivation of catecholamines. Catecholamines 78-92 catechol-O-methyltransferase Homo sapiens 12-40 12564841-1 2002 BACKGROUND: Catechol-O-methyltransferase (COMT) catalyses the inactivation of catecholamines. Catecholamines 78-92 catechol-O-methyltransferase Homo sapiens 42-46 12564841-9 2002 CONCLUSION: The established assay method used to assess S- and MB-COMT activities in human erythrocytes could be useful to elucidate catecholamine metabolism in the normal physiological state as well as in the pathology of certain diseases. Catecholamines 133-146 catechol-O-methyltransferase Homo sapiens 66-70 12384962-6 2002 The gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine biosynthesis, is regulated by hypoxia in the CB and in the oxygen-sensitive cultured PC12 cell line. Catecholamines 79-92 tyrosine hydroxylase Rattus norvegicus 23-43 12439640-20 2002 Both, permanent stimulation with catecholamines and chronic treatment with agonistic anti-beta1-adrenoceptor autoantibodies cause a reduction of the expression of the beta1-adrenoceptor on mRNA and protein level in "in vitro" experiments. Catecholamines 33-47 adrenoceptor beta 1 Homo sapiens 167-185 12196512-9 2002 These results suggest that PAG608 may induce or regulate p53 expression and translocate to the nucleus and nucleolus using its first zinc finger domain during oxidative stress-induced apoptosis of catecholamine-containing cells. Catecholamines 197-210 zinc finger, matrin type 3 Rattus norvegicus 27-33 12417669-4 2002 We investigated whether the downregulation of the enzyme aromatic l-amino acid decarboxylase (AADC) or the TH cofactor tetrahydrobiopterin (BH4) could account for the loss of catecholamines in these neurons. Catecholamines 175-189 dopa decarboxylase Mus musculus 94-98 12384962-6 2002 The gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme for catecholamine biosynthesis, is regulated by hypoxia in the CB and in the oxygen-sensitive cultured PC12 cell line. Catecholamines 79-92 tyrosine hydroxylase Rattus norvegicus 45-47 12491788-0 2002 [V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner]. Catecholamines 8-21 immunoglobulin kappa variable 1-5 Homo sapiens 1-4 12538968-2 2002 There are, in the literature, several cases of septic shock refractory to high-dose catecholamines successfully treated with arginine-vasopressin, a selective V1 agonist. Catecholamines 84-98 arginine vasopressin Homo sapiens 134-145 12491788-0 2002 [V-1, a catecholamine biosynthesis regulatory protein, enhances GTP cyclohydrolase I gene transcription in a cAMP-responsive element dependent manner]. Catecholamines 8-21 GTP cyclohydrolase 1 Rattus norvegicus 64-84 12491788-2 2002 Recently we have for the first time reported that stable overexpression of V-1 enhances mRNA expression of catecholamine synthesizing enzymes in PC12D cells, and as a result, catecholamine production is upregulated. Catecholamines 107-120 immunoglobulin kappa variable 1-5 Homo sapiens 75-78 12491798-1 2002 beta-Adrenoceptor subtypes which mediate relaxation of guinea-pig gastrointestinal smooth muscles in response to catecholamines ((-)-isoprenaline, (-)-noradrenaline and (-)-adrenaline) and beta 3-adrenoceptor agonists (BRL37344 and (+/-)-CGP12177A) are predominantly beta 3-adrenoceptors. Catecholamines 113-127 beta-3 adrenergic receptor Cavia porcellus 189-208 12491788-2 2002 Recently we have for the first time reported that stable overexpression of V-1 enhances mRNA expression of catecholamine synthesizing enzymes in PC12D cells, and as a result, catecholamine production is upregulated. Catecholamines 175-188 immunoglobulin kappa variable 1-5 Homo sapiens 75-78 12491798-5 2002 In gastric fundus smooth muscle, catecholamines and beta 3-adrenoceptor agonists elicited potent relaxations in the presence of beta 1- and beta 2-adrenoceptor antagonists. Catecholamines 33-47 beta-2 adrenergic receptor Cavia porcellus 128-159 12409526-2 2002 We studied transcripts for the catecholamine synthesizing enzyme tyrosine hydroxylase (TH) and the neuropeptide galanin (GAL) in locus ceruleus (LC) and adrenal medulla at different times after birth and postnatal hypoxia. Catecholamines 31-44 tyrosine hydroxylase Mus musculus 65-85 12409526-2 2002 We studied transcripts for the catecholamine synthesizing enzyme tyrosine hydroxylase (TH) and the neuropeptide galanin (GAL) in locus ceruleus (LC) and adrenal medulla at different times after birth and postnatal hypoxia. Catecholamines 31-44 tyrosine hydroxylase Mus musculus 87-89 12387862-1 2002 Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the beta-adrenoceptors (beta(1)/beta(2)/beta(3)). Catecholamines 0-14 hemoglobin, beta adult major chain Mus musculus 152-159 12196528-3 2002 To reveal the molecular mechanism to regulate the expression of tyrosine hydroxylase (TH), which is the rate-limiting enzyme for catecholamine biosynthesis, we analyzed the transcription factors responsible for TH induction in the V-1 clonal cells. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 64-84 12196528-3 2002 To reveal the molecular mechanism to regulate the expression of tyrosine hydroxylase (TH), which is the rate-limiting enzyme for catecholamine biosynthesis, we analyzed the transcription factors responsible for TH induction in the V-1 clonal cells. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 86-88 12196528-7 2002 These data demonstrated that activation of ATF-2 resulted in the increased transcription of the TH gene and suggest that ATF-2 may be deeply involved in the transcriptional regulation of catecholamine-synthesizing genes during neural development. Catecholamines 187-200 activating transcription factor 2 Rattus norvegicus 43-48 12196528-7 2002 These data demonstrated that activation of ATF-2 resulted in the increased transcription of the TH gene and suggest that ATF-2 may be deeply involved in the transcriptional regulation of catecholamine-synthesizing genes during neural development. Catecholamines 187-200 tyrosine hydroxylase Rattus norvegicus 96-98 12387862-1 2002 Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the beta-adrenoceptors (beta(1)/beta(2)/beta(3)). Catecholamines 0-14 hemoglobin, beta adult minor chain Mus musculus 160-167 12196528-7 2002 These data demonstrated that activation of ATF-2 resulted in the increased transcription of the TH gene and suggest that ATF-2 may be deeply involved in the transcriptional regulation of catecholamine-synthesizing genes during neural development. Catecholamines 187-200 activating transcription factor 2 Rattus norvegicus 121-126 12387862-1 2002 Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the beta-adrenoceptors (beta(1)/beta(2)/beta(3)). Catecholamines 0-14 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 168-175 12438119-3 2002 Both PLD activation and catecholamine secretion are strongly inhibited by a synthetic peptide corresponding to the N-terminal domain of ARF6. Catecholamines 24-37 ADP ribosylation factor 6 Homo sapiens 136-140 12399592-1 2002 Catecholamines signal through the beta2-adrenergic receptor by promoting production of the second messenger adenosine 3",5"-monophosphate (cAMP). Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 34-59 12393054-1 2002 A 40-kDa catecholamine-regulated protein (CRP40) has been demonstrated to be expressed in the central nervous system, and is known to bind to dopamine and related catecholamines. Catecholamines 163-177 heat shock protein family A (Hsp70) member 9 Rattus norvegicus 42-47 12220731-5 2002 W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. Catecholamines 83-97 Rho GTPase activating protein 45 Homo sapiens 14-17 12220731-5 2002 W(max) at SL, HA1 and HA5 increased CGRP and AM along with heart rate, lactate and catecholamines, whereas, calcitonin remained unchanged. Catecholamines 83-97 keratin 35 Homo sapiens 22-25 12438119-5 2002 Using permeabilized cells, we found that the introduction of anti-ARNO antibodies into the cytosol inhibits both PLD activation and catecholamine secretion. Catecholamines 132-145 cytohesin 2 Homo sapiens 66-70 12438119-7 2002 We found that microinjection of the catalytically inactive PLD1(K898R) dramatically reduces catecholamine secretion monitored by amperometry, most likely by interfering with a late postdocking step of calcium-regulated exocytosis. Catecholamines 92-105 phospholipase D1 Homo sapiens 59-63 12438131-0 2002 Calmodulin inhibitors block quantal catecholamine release and increase acidification of neurosecretory granules in rat adrenal chromaffin cells. Catecholamines 36-49 calmodulin 1 Rattus norvegicus 0-10 12239109-8 2002 It is concluded that the reduced catecholamine release during the surge in middle-aged rats is caused, in part, by an altered sensitivity of the NE neurons to estradiol, which results in an aberrant cFos expression and probably not by major deficits in the expression of transmitter synthesizing enzymes or steroid receptors. Catecholamines 33-46 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 199-203 12438162-3 2002 These results suggest the presence of a local, functionally active, chromaffin cell plasminogen/plasmin system that plays a major role in the regulation of catecholamine release from catecholaminergic cells. Catecholamines 156-169 plasminogen Homo sapiens 84-91 12438168-1 2002 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an adrenomedullary cotransmitter that along with acetylcholine is responsible for driving catecholamine and neuropeptide biosynthesis and secretion from chromaffin cells in response to stimulation of the splanchnic nerve. Catecholamines 152-165 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 12438168-1 2002 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an adrenomedullary cotransmitter that along with acetylcholine is responsible for driving catecholamine and neuropeptide biosynthesis and secretion from chromaffin cells in response to stimulation of the splanchnic nerve. Catecholamines 152-165 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 12357106-2 2002 The catecholamines, via alpha- and beta-adrenergic receptor (beta-AR) stimulation, may play a role in the development of heart failure. Catecholamines 4-18 adrenergic receptor, beta 1 Mus musculus 61-68 12438173-0 2002 Regulation of catecholamine synthesis by leptin. Catecholamines 14-27 leptin Bos taurus 41-47 12438173-5 2002 In the present study, we examined the effects of leptin on catecholamine synthesis in cultured bovine adrenal medullary cells. Catecholamines 59-72 leptin Bos taurus 49-55 12438173-6 2002 Leptin (3-30 nM) caused a significant increase in (14)C-catecholamine synthesis from [(14)C] tyrosine, but not from [(14)C] DOPA. Catecholamines 56-69 leptin Bos taurus 0-6 12438173-9 2002 U0126, an inhibitor of MAPK kinase, abolished the effect of leptin on (14)C-catecholamine synthesis. Catecholamines 76-89 leptin Bos taurus 60-66 12438173-11 2002 Concurrent treatment of cells with leptin (10 nM) and acetylcholine (0.3 mM) potently enhanced the stimulatory effect of acetylcholine on (14)C-catecholamine synthesis. Catecholamines 144-157 leptin Bos taurus 35-41 12438173-15 2002 These findings suggest that leptin phosphorylates and activates tyrosine hydroxylase and subsequently stimulates catecholamine synthesis through MAPK and probably Ca(2+) pathways in the adrenal medulla. Catecholamines 113-126 leptin Bos taurus 28-34 12239106-8 2002 Likewise, levels of catecholamines in the adrenal medulla and plasma are normal in PACAP null mice raised at a lower temperature. Catecholamines 20-34 adenylate cyclase activating polypeptide 1 Mus musculus 83-88 12437066-7 2002 These data demonstrate that catecholamines inhibit splenocyte proliferation and IL-2 production via a beta-adrenoceptor-induced regulation of IL-2 mRNA expression, indicating that beta-adrenoceptor mechanisms are responsible for behaviorally conditioned immunosuppression. Catecholamines 28-42 interleukin 2 Rattus norvegicus 80-84 12371153-2 2002 In this paper, a unifying hypothesis is proposed which suggests that hyperhomocysteinemia may exert its pathogenic effects largely through metabolic accumulation of S-adenosyl-L-homocysteine, a strong noncompetitive inhibitor of the catechol-O-methyltransferase (COMT)-mediated methylation metabolism of various catechol substrates (such as catecholamines and catechol estrogens). Catecholamines 341-355 catechol-O-methyltransferase Homo sapiens 233-261 12437066-7 2002 These data demonstrate that catecholamines inhibit splenocyte proliferation and IL-2 production via a beta-adrenoceptor-induced regulation of IL-2 mRNA expression, indicating that beta-adrenoceptor mechanisms are responsible for behaviorally conditioned immunosuppression. Catecholamines 28-42 interleukin 2 Rattus norvegicus 142-146 12377295-13 2002 Central CRH, via glucocorticoids and catecholamines, inhibits the inflammatory reaction, while directly secreted by peripheral nerves CRH stimulates local inflammation (immune CRH). Catecholamines 37-51 corticotropin releasing hormone Homo sapiens 8-11 12383241-9 2002 These results suggest that physiologically the recruitment of catecholamine innervation may be important for induction of LTP at hippocampal CA1 synapses during tetanic stimulation, while it may not be essential for LTD induction by prolonged 1 Hz stimulation. Catecholamines 62-75 carbonic anhydrase 1 Rattus norvegicus 141-144 12428766-2 2002 The microsatellite HUMTH01, located in the first intron of the Tyrosine Hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines), is characterized by a TCAT repeated motif and has been used in genetic studies of neuropsychiatric and other complex diseases, in which catecholaminergic neurotransmission is implicated. Catecholamines 149-163 tyrosine hydroxylase Homo sapiens 63-83 12428766-2 2002 The microsatellite HUMTH01, located in the first intron of the Tyrosine Hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines), is characterized by a TCAT repeated motif and has been used in genetic studies of neuropsychiatric and other complex diseases, in which catecholaminergic neurotransmission is implicated. Catecholamines 149-163 tyrosine hydroxylase Homo sapiens 22-24 12412602-10 2002 These results indicate that IGFs decrease catecholamine content in PC12 cells via the IGF-I receptor. Catecholamines 42-55 insulin-like growth factor 1 receptor Rattus norvegicus 86-100 12215478-0 2002 Angiotensin II induces catecholamine release by direct ganglionic excitation. Catecholamines 23-36 angiotensinogen Rattus norvegicus 0-14 12215478-1 2002 Angiotensin II (ANG) is known to facilitate catecholamine release from peripheral sympathetic neurons by enhancing depolarization-dependent exocytosis. Catecholamines 44-57 angiotensinogen Rattus norvegicus 0-14 12215478-1 2002 Angiotensin II (ANG) is known to facilitate catecholamine release from peripheral sympathetic neurons by enhancing depolarization-dependent exocytosis. Catecholamines 44-57 angiotensinogen Rattus norvegicus 16-19 12215478-11 2002 In both the absence and presence of preganglionic sympathetic activity, this mechanism contributes significantly to ANG-induced enhancement of catecholamine release. Catecholamines 143-156 angiotensinogen Rattus norvegicus 116-119 19649237-8 2002 CONCLUSIONS: The activation of p70(S6) kinase and JNK2 may be implicated in the development of catecholamine-induced cardiac hypertrophy in vivo. Catecholamines 95-108 ribosomal protein S6 kinase B1 Rattus norvegicus 31-45 12411742-1 2002 Our previous studies indicated that in the human paraventricular (PVN) and supraoptic (SON) nuclei, tyrosine hydroxylase (TH)--the first and rate-limiting enzyme in catecholamine synthesis--is localized mainly in magnocellular neurons and that antemortem factors regulate its expression. Catecholamines 165-178 tyrosine hydroxylase Homo sapiens 100-120 12411742-1 2002 Our previous studies indicated that in the human paraventricular (PVN) and supraoptic (SON) nuclei, tyrosine hydroxylase (TH)--the first and rate-limiting enzyme in catecholamine synthesis--is localized mainly in magnocellular neurons and that antemortem factors regulate its expression. Catecholamines 165-178 tyrosine hydroxylase Homo sapiens 122-124 12399106-3 2002 One manifestation of the behavioral changes resulting from chronic use of morphine is the upregulation of tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine biosynthesis), which contributes to the dramatic increases in catecholamine release in the target regions of the locus coeruleus (LC) and the ventral tegmental area (VTA). Catecholamines 160-173 tyrosine hydroxylase Homo sapiens 106-126 12399106-3 2002 One manifestation of the behavioral changes resulting from chronic use of morphine is the upregulation of tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine biosynthesis), which contributes to the dramatic increases in catecholamine release in the target regions of the locus coeruleus (LC) and the ventral tegmental area (VTA). Catecholamines 160-173 tyrosine hydroxylase Homo sapiens 128-130 12399106-3 2002 One manifestation of the behavioral changes resulting from chronic use of morphine is the upregulation of tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine biosynthesis), which contributes to the dramatic increases in catecholamine release in the target regions of the locus coeruleus (LC) and the ventral tegmental area (VTA). Catecholamines 236-249 tyrosine hydroxylase Homo sapiens 106-126 12399106-3 2002 One manifestation of the behavioral changes resulting from chronic use of morphine is the upregulation of tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine biosynthesis), which contributes to the dramatic increases in catecholamine release in the target regions of the locus coeruleus (LC) and the ventral tegmental area (VTA). Catecholamines 236-249 tyrosine hydroxylase Homo sapiens 128-130 12463966-0 2002 Comparative study of catecholamine synthesizing enzymes in adrenal medulla of CRH knock-out mice, their CRH (+/+) mates and Sprague-Dawley rats. Catecholamines 21-34 corticotropin releasing hormone Mus musculus 78-81 12358777-3 2002 Here we show that GDNF can support the function of primary dopaminergic neurones by triggering activation of GTP-cyclohydrolase I (GTPCH I), a key enzyme in catecholamine biosynthesis. Catecholamines 157-170 glial cell derived neurotrophic factor Homo sapiens 18-22 12213855-0 2002 Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. Catecholamines 19-32 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 113-136 12213855-3 2002 Mutations in succinate dehydrogenase (SDH) subunit genes have been identified in some kindreds with catecholamine-secreting tumors. Catecholamines 100-113 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 13-36 12213855-3 2002 Mutations in succinate dehydrogenase (SDH) subunit genes have been identified in some kindreds with catecholamine-secreting tumors. Catecholamines 100-113 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 38-41 12358777-3 2002 Here we show that GDNF can support the function of primary dopaminergic neurones by triggering activation of GTP-cyclohydrolase I (GTPCH I), a key enzyme in catecholamine biosynthesis. Catecholamines 157-170 GTP cyclohydrolase 1 Homo sapiens 109-129 12358777-3 2002 Here we show that GDNF can support the function of primary dopaminergic neurones by triggering activation of GTP-cyclohydrolase I (GTPCH I), a key enzyme in catecholamine biosynthesis. Catecholamines 157-170 GTP cyclohydrolase 1 Homo sapiens 131-138 12186684-4 2002 In association with a significant counter-regulatory response to a single bout of hypoglycemia (elevated corticosterone, catecholamines, and glucagon), TH activity was elevated overall in brainstem NE cell body areas and hypothalamus. Catecholamines 121-135 tyrosine hydroxylase Rattus norvegicus 152-154 12181441-1 2002 The regulation of tyrosine hydroxylase (TH) represents an effective means to control the level of catecholamines, because TH is the major limiting enzyme of monoamine biosynthesis. Catecholamines 98-112 tyrosine hydroxylase Mus musculus 18-38 12181441-1 2002 The regulation of tyrosine hydroxylase (TH) represents an effective means to control the level of catecholamines, because TH is the major limiting enzyme of monoamine biosynthesis. Catecholamines 98-112 tyrosine hydroxylase Mus musculus 40-42 12181441-1 2002 The regulation of tyrosine hydroxylase (TH) represents an effective means to control the level of catecholamines, because TH is the major limiting enzyme of monoamine biosynthesis. Catecholamines 98-112 tyrosine hydroxylase Mus musculus 122-124 12349904-7 2002 Stimulants, for example, catecholamines can evoke marked Mg2+ efflux which appears to be associated with a concomitant increase in the force of contraction of the heart. Catecholamines 25-39 mucin 7, secreted Homo sapiens 57-60 12183654-0 2002 Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells. Catecholamines 127-141 adenylate cyclase activating polypeptide 1 Bos taurus 0-50 12183654-1 2002 Characteristics of pituitary adenylate cyclase-activating polypeptide (PACAP)-induced increase of Ca(2+) entry and catecholamine (CA) release were studied in bovine adrenal medullary chromaffin cells. Catecholamines 115-128 adenylate cyclase activating polypeptide 1 Bos taurus 19-69 12183654-1 2002 Characteristics of pituitary adenylate cyclase-activating polypeptide (PACAP)-induced increase of Ca(2+) entry and catecholamine (CA) release were studied in bovine adrenal medullary chromaffin cells. Catecholamines 115-128 adenylate cyclase activating polypeptide 1 Bos taurus 71-76 12034720-1 2002 The beta(1)-adrenergic receptor (beta(1)AR) is a major mediator of catecholamine effects in human heart. Catecholamines 67-80 adrenoceptor beta 1 Homo sapiens 4-42 12235856-0 2002 [Possible role of a neuropeptide PACAP (pituitary adenylate cyclase-activating polypeptide) on stimulus-secretion coupling in catecholamine neuron]. Catecholamines 126-139 adenylate cyclase activating polypeptide 1 Bos taurus 33-38 12235856-0 2002 [Possible role of a neuropeptide PACAP (pituitary adenylate cyclase-activating polypeptide) on stimulus-secretion coupling in catecholamine neuron]. Catecholamines 126-139 adenylate cyclase activating polypeptide 1 Bos taurus 40-90 12235856-4 2002 The authors have investigated the role of PACAP on catecholamine biosynthesis and secretion using cultured bovine adrenal chromaffin cells as a model for catecholamine-containing neurons. Catecholamines 51-64 adenylate cyclase activating polypeptide 1 Bos taurus 42-47 12188925-12 2002 CONCLUSIONS: Mice with reduced or absent COMT activity have altered metabolism of catecholamines and are unable to increase renal DA activity and produce normal natriuresis in response to acute sodium loading. Catecholamines 82-96 catechol-O-methyltransferase Mus musculus 41-45 12391525-3 2002 Recent studies have shown that arginine vasopressin, an endogenous hormone of the neurohypophysis, may be a potent vasopressor when used in combination with catecholamines. Catecholamines 157-171 arginine vasopressin Homo sapiens 40-51 12137927-0 2002 Regulation of norepinephrine transporter abundance by catecholamines and desipramine in vivo. Catecholamines 54-68 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 14-40 12180588-0 2002 The use of vasopressin to treat catecholamine-resistant hypotension after phaeochromocytoma removal. Catecholamines 32-45 arginine vasopressin Homo sapiens 11-22 12180588-4 2002 The experience with this case suggests that vasopressin may be a useful adjunct in the treatment of catecholamine-resistant hypotension after phaeochromocytoma excision. Catecholamines 100-113 arginine vasopressin Homo sapiens 44-55 12391525-4 2002 During catecholamine-resistant septic and postcardiotomy shock, argine vasopressin results in a significant increase in mean arterial pressure as well as a significant decrease in heart rate and vasopressor requirements. Catecholamines 7-20 arginine vasopressin Homo sapiens 71-82 12404674-0 2002 Effects of serotonin and catecholamine depletion on interleukin-6 activation and mood in human volunteers. Catecholamines 25-38 interleukin 6 Homo sapiens 52-65 12163813-1 2002 OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock. Catecholamines 149-162 arginine vasopressin Homo sapiens 119-130 12126868-1 2002 Genetic polymorphism of catechol-O-methyltransferase (COMT), involved in the degradation of catecholamine neurotransmitters, has been investigated as a candidate for modifier of susceptibility to development of schizophrenia. Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 24-52 12126868-1 2002 Genetic polymorphism of catechol-O-methyltransferase (COMT), involved in the degradation of catecholamine neurotransmitters, has been investigated as a candidate for modifier of susceptibility to development of schizophrenia. Catecholamines 92-105 catechol-O-methyltransferase Homo sapiens 54-58 12145102-4 2002 2: Our findings showed that hydrogen peroxide (H(2)O(2)) stimulated rapid and significant activation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK) and p38 in PC12 cells, which is a model of catecholamine-containing neurons. Catecholamines 225-238 mitogen activated protein kinase 3 Rattus norvegicus 104-150 12153741-1 2002 OBJECTIVE: We describe a patient with an ACTH-producing phaeochromocytoma who initially presented with hypercortisolism and normal catecholamine concentrations, followed by near-normalisation of ACTH secretion and massive catecholamine secretion. Catecholamines 131-144 proopiomelanocortin Homo sapiens 41-45 12153741-1 2002 OBJECTIVE: We describe a patient with an ACTH-producing phaeochromocytoma who initially presented with hypercortisolism and normal catecholamine concentrations, followed by near-normalisation of ACTH secretion and massive catecholamine secretion. Catecholamines 222-235 proopiomelanocortin Homo sapiens 41-45 12203704-10 2002 The current article also reviews the distribution of nerve fibers containing substance P (SP), another sensory nerve-specific neuropeptide, and tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine. Catecholamines 199-212 tyrosine hydroxylase Mus musculus 144-164 12133851-2 2002 We tested the hypothesis that SET (90 min/day, 5 days/wk, for 12 wk) elevates mRNA expression of catecholamine (CA) biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DbetaH) in the adrenal medullae of adult, female Sprague-Dawley rats. Catecholamines 97-110 tyrosine hydroxylase Rattus norvegicus 160-162 12373866-1 2002 It has recently been reported that the human striatum, especially its ventral part, the nucleus accumbens, contains numerous neurons immunoreactive for aromatic L-amino acid decarboxylase (AADC; the second-step monoamine synthesizing enzyme), but not for tyrosine hydroxylase (TH; the first-step catecholamine synthesizing enzyme) or tryptophan hydroxylase (TPH; the first-step serotonin synthesizing enzyme). Catecholamines 296-309 dopa decarboxylase Homo sapiens 189-193 12151739-3 2002 The influence of catecholamine pretreatment on tumor necrosis factor (TNF)-alpha-mediated production of these chemokines and the expression of adhesion molecules was also tested. Catecholamines 17-30 tumor necrosis factor Homo sapiens 47-80 12100068-1 2002 OBJECTIVE: Chromogranin A (CgA) is an acidic glycoprotein co-stored in vesicles and co-released with catecholamines. Catecholamines 101-115 chromogranin A Homo sapiens 11-25 11994295-5 2002 In vivo, the ratio of bound GDP/GTP and phosphorylation of annexin 7 change in direct proportion to the extent of catecholamine release from chromaffin cells in response to stimulation by carbachol, or to inhibition by various protein kinase C inhibitors. Catecholamines 114-127 annexin A7 Homo sapiens 59-68 12107377-4 2002 Among the most detailed mediators studied are corticotropin-releasing factor and serotonin which, via the hypothalamic-pituitary-adrenal axis and the sympathetic and parasympathetic nervous system, stimulate catecholamines and cortisol and inhibit anabolic hormones, insulin, leptin, ghrelin, including neuropeptide Y and other neuropeptides, among them the paracrine-acting cytokines. Catecholamines 208-222 corticotropin releasing hormone Homo sapiens 46-76 12107377-4 2002 Among the most detailed mediators studied are corticotropin-releasing factor and serotonin which, via the hypothalamic-pituitary-adrenal axis and the sympathetic and parasympathetic nervous system, stimulate catecholamines and cortisol and inhibit anabolic hormones, insulin, leptin, ghrelin, including neuropeptide Y and other neuropeptides, among them the paracrine-acting cytokines. Catecholamines 208-222 insulin Homo sapiens 267-274 12107377-4 2002 Among the most detailed mediators studied are corticotropin-releasing factor and serotonin which, via the hypothalamic-pituitary-adrenal axis and the sympathetic and parasympathetic nervous system, stimulate catecholamines and cortisol and inhibit anabolic hormones, insulin, leptin, ghrelin, including neuropeptide Y and other neuropeptides, among them the paracrine-acting cytokines. Catecholamines 208-222 leptin Homo sapiens 276-282 12100068-1 2002 OBJECTIVE: Chromogranin A (CgA) is an acidic glycoprotein co-stored in vesicles and co-released with catecholamines. Catecholamines 101-115 chromogranin A Homo sapiens 27-30 12080442-8 2002 Both catecholamines increased IL-6 and leptin secretion. Catecholamines 5-19 interleukin 6 Homo sapiens 30-34 12100068-11 2002 At variance with blood pressure and catecholamines, CgA increased significantly in the afternoon (51.1 +/- 4.0 vs. 45.0 +/- 3.9 microg/l, P < 0.05); it also had a circadian rhythm, with peak values during the night (at 2300 h, 65.4 +/- 9.0 microg/l) and a nadir in the morning (at 0800 h, 43.1 +/- 6.6 microg/l). Catecholamines 36-50 chromogranin A Homo sapiens 52-55 12080442-9 2002 The effects of dexamethasone and catecholamines on IL-6 and leptin were abrogated by RU486 and propranolol, respectively. Catecholamines 33-47 interleukin 6 Homo sapiens 51-55 12093887-5 2002 GLP-1R activation induced c-fos expression in the adrenal medulla and neurons in autonomic control sites in the rat brain, including medullary catecholamine neurons providing input to sympathetic preganglionic neurons. Catecholamines 143-156 glucagon-like peptide 1 receptor Rattus norvegicus 0-6 12093887-6 2002 Furthermore, GLP-1R agonists rapidly activated tyrosine hydroxylase transcription in brainstem catecholamine neurons. Catecholamines 95-108 glucagon-like peptide 1 receptor Rattus norvegicus 13-19 12077369-1 2002 Ca2+-triggered catecholamine exocytosis from chromaffin cells involves SNAP-25, synaptobrevin and syntaxin (known as SNAREs). Catecholamines 15-28 synaptosome associated protein 25 Homo sapiens 71-78 12037376-0 2002 Interleukin-1beta-induced increases of plasma catecholamine levels in rats: enhancement by superior cervical ganglionectomy. Catecholamines 46-59 interleukin 1 beta Rattus norvegicus 0-17 12131530-0 2002 Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension. Catecholamines 21-34 chromogranin A Homo sapiens 62-72 12131530-2 2002 Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholamine release as an antagonist at the physiologic trigger for secretion, the neuronal nicotinic cholinergic receptor. Catecholamines 57-71 chromogranin A Homo sapiens 0-14 12131530-2 2002 Chromogranin A is a pro-hormone stored and released with catecholamines by exocytosis; its fragment catestatin, formed in vivo, inhibits further catecholamine release as an antagonist at the physiologic trigger for secretion, the neuronal nicotinic cholinergic receptor. Catecholamines 57-70 chromogranin A Homo sapiens 0-14 12131530-5 2002 Involvement of catestatin in pathophysiology was probed by measurements of catecholamines and leptin, and the hemodynamic responses to environmental (cold) stress. Catecholamines 75-89 chromogranin A Homo sapiens 15-25 12124430-2 2002 Expression of the gene encoding tyrosine hydroxylase (TH), which is a key enzyme of catecholamine biosynthesis, is regulated during the development of midbrain DA neurons. Catecholamines 84-97 tyrosine hydroxylase Rattus norvegicus 32-52 12124430-2 2002 Expression of the gene encoding tyrosine hydroxylase (TH), which is a key enzyme of catecholamine biosynthesis, is regulated during the development of midbrain DA neurons. Catecholamines 84-97 tyrosine hydroxylase Rattus norvegicus 54-56 12139916-2 2002 Mouse pheochromocytoma (MPC) cells respond to the Ret-activating ligand GDNF by exhibiting Ret phosphorylation, neurite outgrowth, decreased proliferation, and altered expression of catecholamine biosynthetic enzymes. Catecholamines 182-195 ret proto-oncogene Mus musculus 50-53 12139916-2 2002 Mouse pheochromocytoma (MPC) cells respond to the Ret-activating ligand GDNF by exhibiting Ret phosphorylation, neurite outgrowth, decreased proliferation, and altered expression of catecholamine biosynthetic enzymes. Catecholamines 182-195 glial cell line derived neurotrophic factor Mus musculus 72-76 12037376-1 2002 In urethane-anesthetized rats, we examined the effect of bilateral superior cervical ganglionectomy on interleukin-1beta (IL-1beta)-induced elevation of plasma catecholamines. Catecholamines 160-174 interleukin 1 beta Rattus norvegicus 103-120 12037376-1 2002 In urethane-anesthetized rats, we examined the effect of bilateral superior cervical ganglionectomy on interleukin-1beta (IL-1beta)-induced elevation of plasma catecholamines. Catecholamines 160-174 interleukin 1 beta Rattus norvegicus 122-130 12134808-4 2002 Catecholamine derivatives were retained on poly(IPAAm-co-AAc-co-tBAAm)-modified column at pH 7.0. Catecholamines 0-13 glycine-N-acyltransferase Homo sapiens 57-60 12095132-2 2002 Since burn trauma causes a rise in circulating catecholamine levels, we hypothesized that this increased sympathetic activity may function as an upstream activator of the p38 MARK pathway in burn trauma. Catecholamines 47-60 mitogen activated protein kinase 14 Rattus norvegicus 171-174 12187940-6 2002 All pheochromocytomas were strongly immunoreactive for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 110-123 tyrosine hydroxylase Rattus norvegicus 55-75 12083324-1 2002 The metabolic O-methylation of endogenous catecholamines and other catechols catalyzed by catechol-O-methyltransferase (COMT; EC 2.1.1.6) was first described by Dr. Julix Axelrod and his colleagues almost half a century ago. Catecholamines 42-56 catechol-O-methyltransferase Homo sapiens 90-118 12036350-2 2002 MIF also catalyzes the tautomerization of the non-naturally occurring D-isomer of dopachrome, phenylpyruvate, and certain catecholamines, suggesting that MIF might exert its biological effects via enzymatic action on a substrate. Catecholamines 122-136 macrophage migration inhibitory factor Homo sapiens 0-3 12036350-2 2002 MIF also catalyzes the tautomerization of the non-naturally occurring D-isomer of dopachrome, phenylpyruvate, and certain catecholamines, suggesting that MIF might exert its biological effects via enzymatic action on a substrate. Catecholamines 122-136 macrophage migration inhibitory factor Homo sapiens 154-157 12079839-11 2002 Expression of regulatory G-proteins, which are essential for both catecholamine and insulin signaling in adipocytes, was also altered by ectopic UCP1. Catecholamines 66-79 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 145-149 12114286-1 2002 Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, whereas they stimulate the production of antiinflammatory cytokines, such as IL-10, IL-4, and transforming growth factor (TGF)-beta. Catecholamines 51-65 tumor necrosis factor Homo sapiens 176-209 12114286-1 2002 Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, whereas they stimulate the production of antiinflammatory cytokines, such as IL-10, IL-4, and transforming growth factor (TGF)-beta. Catecholamines 51-65 interferon gamma Homo sapiens 215-237 12114286-1 2002 Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, whereas they stimulate the production of antiinflammatory cytokines, such as IL-10, IL-4, and transforming growth factor (TGF)-beta. Catecholamines 51-65 interleukin 10 Homo sapiens 316-321 12114286-1 2002 Recent evidence indicates that glucocorticoids and catecholamines, the major stress hormones, inhibit the production of proinflammatory cytokines, such as interleukin (IL)-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, whereas they stimulate the production of antiinflammatory cytokines, such as IL-10, IL-4, and transforming growth factor (TGF)-beta. Catecholamines 51-65 interleukin 4 Homo sapiens 323-327 12107681-1 2002 OBJECTIVE: Arginine-vasopressin (AVP) might be a potent vasopressor agent in catecholamine-resistant postcardiotomy shock. Catecholamines 77-90 arginine vasopressin Homo sapiens 20-31 12050216-6 2002 VIP and PACAP concentration-dependently increased aldosterone and catecholamine secretion from cultured ZG and AM cells. Catecholamines 66-79 vasoactive intestinal peptide Homo sapiens 0-3 12050216-6 2002 VIP and PACAP concentration-dependently increased aldosterone and catecholamine secretion from cultured ZG and AM cells. Catecholamines 66-79 adenylate cyclase activating polypeptide 1 Homo sapiens 8-13 12105086-2 2002 Tyrosine hydroxylase (TH), the rate-limiting enzyme of the synthetic pathway of catecholamines, is a good marker to assess potential effects of Meth in catecholaminergic (particularly in dopaminergic) systems. Catecholamines 80-94 tyrosine hydroxylase Rattus norvegicus 0-20 12105086-2 2002 Tyrosine hydroxylase (TH), the rate-limiting enzyme of the synthetic pathway of catecholamines, is a good marker to assess potential effects of Meth in catecholaminergic (particularly in dopaminergic) systems. Catecholamines 80-94 tyrosine hydroxylase Rattus norvegicus 22-24 12050216-9 2002 The catecholamine response of cultured AM cells to VIP was lowered by VPAC(1)-A and unaffected by PAC(1)-A; conversely, the catecholamine response to PACAP was reduced by both PAC(1)-A and VPAC(1)-A. Catecholamines 4-17 vasoactive intestinal peptide Homo sapiens 51-54 12050216-9 2002 The catecholamine response of cultured AM cells to VIP was lowered by VPAC(1)-A and unaffected by PAC(1)-A; conversely, the catecholamine response to PACAP was reduced by both PAC(1)-A and VPAC(1)-A. Catecholamines 4-17 vasoactive intestinal peptide receptor 1 Homo sapiens 70-77 12023685-1 2002 BACKGROUND: Angiotensin II is known to facilitate the release of catecholamines from peripheral sympathetic neurons by stimulating presynaptically located receptors. Catecholamines 65-79 angiotensinogen Rattus norvegicus 12-26 12050216-9 2002 The catecholamine response of cultured AM cells to VIP was lowered by VPAC(1)-A and unaffected by PAC(1)-A; conversely, the catecholamine response to PACAP was reduced by both PAC(1)-A and VPAC(1)-A. Catecholamines 4-17 ADCYAP receptor type I Homo sapiens 71-77 12050216-9 2002 The catecholamine response of cultured AM cells to VIP was lowered by VPAC(1)-A and unaffected by PAC(1)-A; conversely, the catecholamine response to PACAP was reduced by both PAC(1)-A and VPAC(1)-A. Catecholamines 4-17 vasoactive intestinal peptide receptor 1 Homo sapiens 70-76 12050216-9 2002 The catecholamine response of cultured AM cells to VIP was lowered by VPAC(1)-A and unaffected by PAC(1)-A; conversely, the catecholamine response to PACAP was reduced by both PAC(1)-A and VPAC(1)-A. Catecholamines 124-137 adenylate cyclase activating polypeptide 1 Homo sapiens 150-155 12023685-4 2002 DESIGN: We studied angiotensin II-induced catecholamine release and vasoconstriction in pithed, spontaneously hypertensive rats under the influence of candesartan, eprosartan, EXP 3174, and irbesartan. Catecholamines 42-55 angiotensinogen Rattus norvegicus 19-33 12023693-1 2002 OBJECTIVE: Both adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP), processed from the same precursor of prepro-adrenomedullin (preproAM), have differential biological properties; AM dilates blood vessels and presumably affects the vascular remodeling, while PAMP inhibits catecholamine secretion. Catecholamines 294-307 adrenomedullin Homo sapiens 40-80 12023693-1 2002 OBJECTIVE: Both adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP), processed from the same precursor of prepro-adrenomedullin (preproAM), have differential biological properties; AM dilates blood vessels and presumably affects the vascular remodeling, while PAMP inhibits catecholamine secretion. Catecholamines 294-307 adrenomedullin Homo sapiens 82-86 12023693-1 2002 OBJECTIVE: Both adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP), processed from the same precursor of prepro-adrenomedullin (preproAM), have differential biological properties; AM dilates blood vessels and presumably affects the vascular remodeling, while PAMP inhibits catecholamine secretion. Catecholamines 294-307 adrenomedullin Homo sapiens 126-147 12023693-1 2002 OBJECTIVE: Both adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP), processed from the same precursor of prepro-adrenomedullin (preproAM), have differential biological properties; AM dilates blood vessels and presumably affects the vascular remodeling, while PAMP inhibits catecholamine secretion. Catecholamines 294-307 adrenomedullin Homo sapiens 149-157 15177064-1 2002 The inhibition of catechol-O-methyltransferase (COMT) may impair catecholamine clearance resulting in unwanted cardiac and hemodynamic events. Catecholamines 65-78 catechol-O-methyltransferase Homo sapiens 18-46 12126736-0 2002 Immunotoxic catecholamine lesions attenuate 2DG-induced increase of AGRP mRNA. Catecholamines 12-25 agouti related neuropeptide Homo sapiens 68-72 12200739-2 2002 Lack of AADC leads to a combined deficiency of the catecholamines DA, norepinephrine (NE), epinephrine (E) as well as of serotonin. Catecholamines 51-65 dopa decarboxylase Homo sapiens 8-12 15177064-1 2002 The inhibition of catechol-O-methyltransferase (COMT) may impair catecholamine clearance resulting in unwanted cardiac and hemodynamic events. Catecholamines 65-78 catechol-O-methyltransferase Homo sapiens 48-52 12023049-1 2002 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines. Catecholamines 74-88 tyrosine hydroxylase Homo sapiens 0-20 12023049-1 2002 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines. Catecholamines 74-88 tyrosine hydroxylase Homo sapiens 22-24 11984299-1 2002 PURPOSE: This study was designed to investigate the acute plasma catecholamine (CA) response to resistance exercise and its association with serum testosterone (TES), cortisol (COR), and growth hormone (GH) concentration changes. Catecholamines 65-78 growth hormone 1 Homo sapiens 187-201 11978010-4 2002 This release of annexin 2 is specific, correlated with catecholamine secretion, and independent of cell death. Catecholamines 55-68 annexin A2 Homo sapiens 16-25 12051753-1 2002 Three of the catecholamine-synthesizing enzymes, i.e., tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine beta-hydroxylase, were earlier shown to be up-regulated in cloned PC12D cells overexpressing V-1, a cdc10/SWI6 motif-containing protein. Catecholamines 13-26 tyrosine hydroxylase Rattus norvegicus 55-75 12051753-1 2002 Three of the catecholamine-synthesizing enzymes, i.e., tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine beta-hydroxylase, were earlier shown to be up-regulated in cloned PC12D cells overexpressing V-1, a cdc10/SWI6 motif-containing protein. Catecholamines 13-26 tyrosine hydroxylase Rattus norvegicus 77-79 12051753-1 2002 Three of the catecholamine-synthesizing enzymes, i.e., tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine beta-hydroxylase, were earlier shown to be up-regulated in cloned PC12D cells overexpressing V-1, a cdc10/SWI6 motif-containing protein. Catecholamines 13-26 dopamine beta-hydroxylase Rattus norvegicus 123-148 12051753-1 2002 Three of the catecholamine-synthesizing enzymes, i.e., tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase, and dopamine beta-hydroxylase, were earlier shown to be up-regulated in cloned PC12D cells overexpressing V-1, a cdc10/SWI6 motif-containing protein. Catecholamines 13-26 septin 7 Rattus norvegicus 232-237 12045467-1 2002 BACKGROUND: Monoamine oxidase B (MAO-B) degrades catecholamines in presynaptic nerve endings and is also active in platelets. Catecholamines 49-63 monoamine oxidase B Homo sapiens 12-31 12045467-1 2002 BACKGROUND: Monoamine oxidase B (MAO-B) degrades catecholamines in presynaptic nerve endings and is also active in platelets. Catecholamines 49-63 monoamine oxidase B Homo sapiens 33-38 12019333-1 2002 Chronic opiate exposure induces numerous neurochemical adaptations in the noradrenergic system, including upregulation of the cAMP-signaling pathway and increased expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 232-245 tyrosine hydroxylase Mus musculus 177-197 12019333-1 2002 Chronic opiate exposure induces numerous neurochemical adaptations in the noradrenergic system, including upregulation of the cAMP-signaling pathway and increased expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 232-245 tyrosine hydroxylase Mus musculus 199-201 12047348-1 2002 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the decarboxylation step in both the catecholamine and indoleamine synthetic pathways. Catecholamines 122-135 dopa decarboxylase Rattus norvegicus 12-47 12047348-1 2002 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) is the enzyme responsible for the decarboxylation step in both the catecholamine and indoleamine synthetic pathways. Catecholamines 122-135 dopa decarboxylase Rattus norvegicus 49-53 12032367-3 2002 Since burn trauma increases circulating catecholamine levels, which in turn modulate inflammatory cytokine production, we hypothesized that increased sympathetic activity after major burn trauma may trigger postburn cardiac p38 MAPK activation via an adrenergic receptor-mediated phenomenon. Catecholamines 40-53 mitogen activated protein kinase 14 Rattus norvegicus 224-227 12065667-1 2002 Aromatic l-amino acid decarboxylase (AADC) is the second enzyme in the catecholamine biosynthetic pathway, and its activity is generally considered not to be limiting, and therefore not involved, in regulating flux through this pathway. Catecholamines 71-84 LOC107131141 Bos taurus 0-35 12065667-1 2002 Aromatic l-amino acid decarboxylase (AADC) is the second enzyme in the catecholamine biosynthetic pathway, and its activity is generally considered not to be limiting, and therefore not involved, in regulating flux through this pathway. Catecholamines 71-84 dopa decarboxylase Bos taurus 37-41 12065667-2 2002 Recent studies showing that its activity can be regulated in vivo and that the enzyme can be phosphorylated and activated in vitro have raised the possibility that AADC may play more than an obligatory role in catecholamine biosynthesis. Catecholamines 210-223 dopa decarboxylase Bos taurus 164-168 11984299-1 2002 PURPOSE: This study was designed to investigate the acute plasma catecholamine (CA) response to resistance exercise and its association with serum testosterone (TES), cortisol (COR), and growth hormone (GH) concentration changes. Catecholamines 65-78 growth hormone 1 Homo sapiens 203-205 12007981-1 2002 The first physiological substrate identified for the extracellular signal-regulated protein kinases (ERKs) is serine 31 in tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 178-191 mitogen-activated protein kinase 1 Homo sapiens 101-105 21179802-7 2002 CONCLUSION: IL-2 inhibited the auto rhythmic of cultured cardiomyocyte directly while the positive chronotropic and arrhythmogenic effects of IL-2 in the isolated rat heart may be mediated by endogenous catecholamine. Catecholamines 203-216 interleukin 2 Rattus norvegicus 142-146 12007519-2 2002 Although beta2-AR has an important role in muscle relaxation via activation of adenylate cyclase, evidence suggests that a third subtype, beta3-AR, which is implicated in metabolic functions of endogenous catecholamines, mediates relaxation of human detrusor muscle. Catecholamines 205-219 adrenoceptor beta 3 Homo sapiens 138-146 12007981-1 2002 The first physiological substrate identified for the extracellular signal-regulated protein kinases (ERKs) is serine 31 in tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 178-191 tyrosine hydroxylase Rattus norvegicus 123-143 12007981-1 2002 The first physiological substrate identified for the extracellular signal-regulated protein kinases (ERKs) is serine 31 in tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 178-191 tyrosine hydroxylase Rattus norvegicus 145-147 11885580-9 2002 The results suggest an acute down-regulation of alpha-2-adrenergic and NPY receptors involved with hypotension in response to hypertensive stimulus, which might be related to an increased availability of catecholamines and NPY in the NTS. Catecholamines 204-218 neuropeptide Y Rattus norvegicus 71-74 11809767-1 2002 The counterregulation of catecholamine action by insulin includes insulin-stimulated sequestration of the beta(2)-adrenergic receptor. Catecholamines 25-38 insulin Homo sapiens 49-56 11809767-1 2002 The counterregulation of catecholamine action by insulin includes insulin-stimulated sequestration of the beta(2)-adrenergic receptor. Catecholamines 25-38 insulin Homo sapiens 66-73 11979726-5 2002 In conclusion, the results of mutant mice suggest that the alternation of catecholamine biosynthesis and cAMP signal pathways may play a key role in development of latent learning and morphine dependence, and they furthermore show that the expression of genes mediated by phosphorylated CREB may be involved in the development of latent learning and morphine dependence. Catecholamines 74-87 cAMP responsive element binding protein 1 Mus musculus 287-291 11967239-3 2002 Because catecholamines are substrates for COMT, which is expressed in GMCs, we hypothesize that catecholamines may abrogate the antimitogenic effects of 2-hydroxyestradiol on GMCs by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 8-22 catechol-O-methyltransferase Rattus norvegicus 197-201 11967239-3 2002 Because catecholamines are substrates for COMT, which is expressed in GMCs, we hypothesize that catecholamines may abrogate the antimitogenic effects of 2-hydroxyestradiol on GMCs by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 96-110 catechol-O-methyltransferase Rattus norvegicus 42-46 11967239-3 2002 Because catecholamines are substrates for COMT, which is expressed in GMCs, we hypothesize that catecholamines may abrogate the antimitogenic effects of 2-hydroxyestradiol on GMCs by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 96-110 catechol-O-methyltransferase Rattus norvegicus 197-201 11967239-12 2002 Moreover, catecholamines may abrogate the renoprotective effects of 2-hydroxyestradiol in the glomeruli by inhibiting COMT and 2-methoxyestradiol formation. Catecholamines 10-24 catechol-O-methyltransferase Rattus norvegicus 118-122 11932285-2 2002 In vitro experiments have shown that stimulation of HSL activity by catecholamines is decreased in FCHL. Catecholamines 68-82 lipase E, hormone sensitive type Homo sapiens 52-55 11932285-3 2002 The aim of this study was to investigate HSL inhibition by insulin and stimulation by endogenous catecholamines in vivo in FCHL patients. Catecholamines 97-111 lipase E, hormone sensitive type Homo sapiens 41-44 11932285-10 2002 Secondly, the induction of HSL activity by endogenous catecholamines in vivo is not decreased in FCHL, in contrast to earlier in vitro findings. Catecholamines 54-68 lipase E, hormone sensitive type Homo sapiens 27-30 11932285-11 2002 Finally, catecholamine-induced HSL activation can be inhibited by insulin in a similar manner in both FCHL and controls. Catecholamines 9-22 lipase E, hormone sensitive type Homo sapiens 31-34 11932285-11 2002 Finally, catecholamine-induced HSL activation can be inhibited by insulin in a similar manner in both FCHL and controls. Catecholamines 9-22 insulin Homo sapiens 66-73 12067224-0 2002 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons. Catecholamines 28-42 caspase 3 Homo sapiens 112-121 12067224-3 2002 Damage to neurons was apparent 12-48 h of post-exposure and there were increases in caspase-3 activity in neurons after 6 h. These changes were paralleled by large increases in pyrimidine and purine base oxidation products, such as 8-OH-guanine suggesting that 5-S-cysteinyl conjugates of catecholamines are capable of diffusing into cells and stimulating the formation of reactive oxygen species (ROS), which may then lead to a mechanism of cell damage involving caspase-3. Catecholamines 289-303 caspase 3 Homo sapiens 84-93 11742001-1 2002 The beta4 subunit is a component of the neuronal nicotinic acetylcholine receptors which control catecholamine secretion in bovine adrenomedullary chromaffin cells. Catecholamines 97-110 adaptor related protein complex 4 subunit beta 1 Homo sapiens 4-9 11919662-7 2002 Fluoxetine at the same dose blocked ex vivo binding to the serotonin transporter, but not the norepinephrine transporter, suggesting that the increase of catecholamines was not due to non-selective blockade of norepinephrine uptake. Catecholamines 154-168 solute carrier family 6 member 4 Rattus norvegicus 59-80 11929611-4 2002 Secretagogues that triggered catecholamine secretion doubled the rate of 125I-transferrin release, the time courses of the two triggered secretory responses being similar. Catecholamines 29-42 serotransferrin Bos taurus 78-89 11929611-6 2002 Triggered 125I-transferrin release, like catecholamine secretion from the same cells, was calcium dependent but the affinities for calcium were very different. Catecholamines 41-54 serotransferrin Bos taurus 15-26 11912140-2 2002 Pheochromocytomas express high levels of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 96-109 tyrosine hydroxylase Rattus norvegicus 41-61 11912140-2 2002 Pheochromocytomas express high levels of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 96-109 tyrosine hydroxylase Rattus norvegicus 63-65 12036114-1 2002 The brain of the adult fruit fly, Drosophila melanogaster, contains tyrosine hydroxylase, the rate-limiting enzyme required for catecholamine biosynthesis, as well as dopa decarboxylase. Catecholamines 128-141 pale Drosophila melanogaster 68-88 11830287-11 2002 These results indicate that orexin-A induces the release of catecholamine from porcine adrenal medullary cells, and aldosterone and cortisol from the cortex cells and has opposite effects on cAMP levels in adrenal medulla and cortex. Catecholamines 60-73 hypocretin neuropeptide precursor Rattus norvegicus 28-36 11748228-0 2002 Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide 3-kinase. Catecholamines 25-38 RAB3A, member RAS oncogene family Rattus norvegicus 49-53 11748228-0 2002 Coordinate regulation of catecholamine uptake by rab3 and phosphoinositide 3-kinase. Catecholamines 25-38 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Rattus norvegicus 58-83 11748228-1 2002 Previously we observed that rab3 GTPases modulate both the secretion of catecholamines from PC12 neuroendocrine cells and the steady-state accumulation of exogenous norepinephrine (NE) into these cells (Weber, E., Jilling, T., and Kirk, K. L. (1996) J. Biol. Catecholamines 72-86 RAB3A, member RAS oncogene family Rattus norvegicus 28-32 11748228-6 2002 rab3A and rab3B also increased NE uptake into large dense core vesicles in digitonin-permeabilized PC12 cells, which indicates that these GTPases stimulate catecholamine uptake at the level of the secretory granule membrane. Catecholamines 156-169 RAB3A, member RAS oncogene family Rattus norvegicus 0-5 11748228-6 2002 rab3A and rab3B also increased NE uptake into large dense core vesicles in digitonin-permeabilized PC12 cells, which indicates that these GTPases stimulate catecholamine uptake at the level of the secretory granule membrane. Catecholamines 156-169 RAB3B, member RAS oncogene family Rattus norvegicus 10-15 11911850-0 2002 Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells. Catecholamines 15-28 endothelin 1 Rattus norvegicus 78-90 11911850-1 2002 It has been reported that endothelins (ETs) stimulate catecholamine release from chromaffin cells. Catecholamines 54-67 endothelin 1 Rattus norvegicus 26-37 11911850-4 2002 The mRNA level and activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, were increased significantly by endothelin-1 (ET-1) (100nM). Catecholamines 84-97 tyrosine hydroxylase Rattus norvegicus 31-51 11911850-4 2002 The mRNA level and activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, were increased significantly by endothelin-1 (ET-1) (100nM). Catecholamines 84-97 tyrosine hydroxylase Rattus norvegicus 53-55 11893370-4 2002 An immediate response to the angor animi and initial symptoms of an acute coronary syndrome is a rapid and marked increase in catecholamine release, which leads to adipose tissue lipolysis with an acute increase in plasma free fatty acid concentrations, suppression of insulin activity, and a reduction in glucose uptake by the myocardium. Catecholamines 126-139 insulin Homo sapiens 269-276 11911850-4 2002 The mRNA level and activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, were increased significantly by endothelin-1 (ET-1) (100nM). Catecholamines 84-97 endothelin 1 Rattus norvegicus 144-156 12014253-3 2002 Both the level and activity of the beta-adrenergic receptor kinase (beta ARK1), a regulatory enzyme that phosphorylates agonist occupied beta-adrenoreceptors, are elevated and account for desensitization of cardiomyocytes to catecholamines. Catecholamines 225-239 G protein-coupled receptor kinase 2 Homo sapiens 68-77 11911850-4 2002 The mRNA level and activity of tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, were increased significantly by endothelin-1 (ET-1) (100nM). Catecholamines 84-97 endothelin 1 Rattus norvegicus 158-162 11911850-8 2002 Moreover, ET-1 (100nM) significantly increased both the TH-protein level and the intracellular catecholamine content. Catecholamines 95-108 endothelin 1 Rattus norvegicus 10-14 11911850-10 2002 These results indicate that ET-1, but not ET-3, stimulates catecholamine synthesis through the PKC pathway in PC12 cells. Catecholamines 59-72 endothelin 1 Rattus norvegicus 28-32 11911850-11 2002 Also, the use of selective ET receptor antagonists suggests that the effects of ET-1 on catecholamine biosynthesis are mediated through ET(A). Catecholamines 88-101 endothelin 1 Rattus norvegicus 80-84 11888852-9 2002 CONCLUSIONS: Our data suggest a role for circulating catecholamines in the prolactin secretion response to stress. Catecholamines 53-67 prolactin Rattus norvegicus 75-84 11958827-1 2002 Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI). Catecholamines 74-87 phenylethanolamine N-methyltransferase Homo sapiens 0-38 11958827-1 2002 Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI). Catecholamines 74-87 phenylethanolamine N-methyltransferase Homo sapiens 40-44 11857463-7 2002 The presence of catecholamines in the non-innervated larval heart together with the finding of TH/DBH/PNMT immunoreactive cells suggests that catecholamines are synthesized and stored in the heart and could therefore have a paracrine role in cardiac control in Xenopus larvae. Catecholamines 142-156 dopamine beta-hydroxylase (dopamine beta-monooxygenase) L homeolog Xenopus laevis 98-101 11812759-14 2002 We concluded that increased catecholamine-induced lipolysis in visceral fat cells may be due to unique alterations in the stoichiometric properties of the adipose PKA-HSL holoenzymes. Catecholamines 28-41 lipase E, hormone sensitive type Homo sapiens 167-170 11853700-4 2002 Boldine (10-100 microM) and 10 microg/mL of superoxide dismutase (SOD) or catalase reduced the effect of catecholamine oxidation on brain mitochondria. Catecholamines 105-118 catalase Rattus norvegicus 74-82 11853700-5 2002 Boldine, SOD, and catalase decreased catecholamine-induced mitochondrial cytochrome c release. Catecholamines 37-50 catalase Rattus norvegicus 18-26 11853700-7 2002 Boldine inhibited the catecholamine-induced decrease in thioredoxin reductase activity and the increase in thiol oxidation in mitochondria. Catecholamines 22-35 peroxiredoxin 5 Rattus norvegicus 56-77 11815511-4 2002 We hypothesized that caffeine reduces insulin sensitivity, either due to catecholamines and/or as a result of blocking adenosine-mediated stimulation of peripheral glucose uptake. Catecholamines 73-87 insulin Homo sapiens 38-45 11864641-0 2002 Role of K+ channels in the PACAP-induced catecholamine secretion from the rat adrenal gland. Catecholamines 41-54 adenylate cyclase activating polypeptide 1 Rattus norvegicus 27-32 11864641-1 2002 We eluciated whether K+ channels modulate adrenal catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP) in the isolated perfused rat adrenal gland. Catecholamines 50-63 adenylate cyclase activating polypeptide 1 Rattus norvegicus 85-135 11864641-1 2002 We eluciated whether K+ channels modulate adrenal catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP) in the isolated perfused rat adrenal gland. Catecholamines 50-63 adenylate cyclase activating polypeptide 1 Rattus norvegicus 137-142 11864641-6 2002 These results suggest that small-conductance Ca2+-activated K+ channels interfere with L-type voltage-dependent Ca2+ channels to counteract the PACAP-induced adrenal catecholamine secretion. Catecholamines 166-179 adenylate cyclase activating polypeptide 1 Rattus norvegicus 144-149 11820929-1 2002 Cytochrome b(561) is a major transmembrane protein of catecholamine and neuropeptide secretory vesicles in the central and peripheral nervous systems of higher animals. Catecholamines 54-67 cytochrome b561 Bos taurus 0-17 11809863-1 2002 The beta(1)-adrenergic receptor (beta(1)-AR) plays a key role in regulating heart rate and contractility in response to catecholamines. Catecholamines 120-134 adrenoceptor beta 1 Homo sapiens 4-43 11805201-0 2002 Angiotensin I-converting enzyme inhibition increases cardiac catecholamine content and reduces monoamine oxidase activity via an angiotensin type 1 receptor-mediated mechanism. Catecholamines 61-74 angiotensin I converting enzyme Rattus norvegicus 0-31 11805201-2 2002 One other important mechanism involves ANG-induced interactions with the sympathetic nervous system, which might include alterations of cardiac catecholamine concentrations during ACE inhibition due to a modulation of monoamine oxidase (MAO) activity. Catecholamines 144-157 angiotensinogen Rattus norvegicus 39-42 11805201-2 2002 One other important mechanism involves ANG-induced interactions with the sympathetic nervous system, which might include alterations of cardiac catecholamine concentrations during ACE inhibition due to a modulation of monoamine oxidase (MAO) activity. Catecholamines 144-157 angiotensin I converting enzyme Rattus norvegicus 180-183 12147212-1 2002 VIP and PACAP38 are closely related peptides that are released in the adrenal gland and sympathetic ganglia and regulate catecholamine synthesis and release. Catecholamines 121-134 vasoactive intestinal peptide Rattus norvegicus 0-3 11867940-3 2002 Since eating behavior disturbances and increased peripheral basal sympathetic activity have been reported in obese subjects, the present study investigated allopregnanolone and catecholamine (epinephrine and norepinephrine) responses to corticotropin-releasing hormone (CRH) in obese subjects. Catecholamines 177-190 corticotropin releasing hormone Homo sapiens 237-268 11782970-10 2002 This finding reveals a role for endogenous catecholamines in the regulation of TNF production. Catecholamines 43-57 tumor necrosis factor Homo sapiens 79-82 11738249-5 2002 Consistent with the porcine data, pretreatment with PACAP or with phorbol ester [phorbol myristate acetate (PMA)] significantly suppressed NIC-induced intracellular Ca(2+) transients and catecholamine secretion in rat chromaffin cells. Catecholamines 187-200 adenylate cyclase activating polypeptide 1 Rattus norvegicus 52-57 11738249-10 2002 These data suggest that PACAP can negatively modulate NIC-induced catecholamine secretion in both porcine and rat adrenal chromaffin cells. Catecholamines 66-79 adenylate cyclase activating polypeptide 1 Rattus norvegicus 24-29 11738249-1 2002 It is well established that pituitary adenylate cyclase-activating polypeptide (PACAP) can stimulate catecholamine biosynthesis and secretion in adrenal chromaffin cells. Catecholamines 101-114 adenylate cyclase activating polypeptide 1 Rattus norvegicus 28-78 11738249-1 2002 It is well established that pituitary adenylate cyclase-activating polypeptide (PACAP) can stimulate catecholamine biosynthesis and secretion in adrenal chromaffin cells. Catecholamines 101-114 adenylate cyclase activating polypeptide 1 Rattus norvegicus 80-85 11738249-2 2002 Recent studies from this laboratory demonstrated that PACAP pretreatment inhibits nicotine (NIC)-induced intracellular Ca(2+) transients and catecholamine secretion in porcine adrenal chromaffin cells. Catecholamines 141-154 adenylate cyclase activating polypeptide 1 Rattus norvegicus 54-59 11784782-1 2002 The catestatin fragment of chromogranin A is the first known endogenous compound able to inhibit catecholamine release elicited by the activation of neuronal nicotinic acetylcholine receptors (nAChRs) of different animal species and catecholaminergic cell types. Catecholamines 97-110 chromogranin A Homo sapiens 4-14 11810719-10 2002 Namely, glucocorticoids, VP, catecholamines, glutamate, and opioids provide short-term or long-lasting effects on differentiating VP neurons. Catecholamines 29-43 arginine vasopressin Homo sapiens 130-132 11784782-1 2002 The catestatin fragment of chromogranin A is the first known endogenous compound able to inhibit catecholamine release elicited by the activation of neuronal nicotinic acetylcholine receptors (nAChRs) of different animal species and catecholaminergic cell types. Catecholamines 97-110 chromogranin A Homo sapiens 27-41 11756684-0 2002 Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Catecholamines 101-114 adenylate cyclase activating polypeptide 1 Mus musculus 0-50 11756684-5 2002 Mice with a targeted deletion of the PACAP gene had otherwise normal cholinergic innervation and morphology of the adrenal medulla, normal adrenal catecholamine and blood glucose levels, and an intact initial catecholamine secretory response to insulin-induced hypoglycemia. Catecholamines 147-160 adenylate cyclase activating polypeptide 1 Mus musculus 37-42 11756684-5 2002 Mice with a targeted deletion of the PACAP gene had otherwise normal cholinergic innervation and morphology of the adrenal medulla, normal adrenal catecholamine and blood glucose levels, and an intact initial catecholamine secretory response to insulin-induced hypoglycemia. Catecholamines 209-222 adenylate cyclase activating polypeptide 1 Mus musculus 37-42 11849292-0 2002 Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. Catecholamines 6-19 catechol-O-methyltransferase Mus musculus 34-62 12545203-4 2002 Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717. Catecholamines 0-13 S-adenosylmethionine decarboxylase 1 Mus musculus 97-131 12545203-4 2002 Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717. Catecholamines 0-13 S-adenosylmethionine decarboxylase 1 Mus musculus 133-141 12545203-4 2002 Catecholamine depletion evoked by reserpine drastically decreases the folate-induced activity of S-adenosylmethionine decarboxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717. Catecholamines 0-13 spermidine/spermine N1-acetyl transferase 1 Mus musculus 202-206 11824863-8 2002 The AT1 receptor antagonist did not affect glucose-mediated insulin responses, but did suppress urinary catecholamine excretion and cardiac alpha1-adrenergic receptor density. Catecholamines 104-117 angiotensin II receptor, type 1a Rattus norvegicus 4-7 12113410-1 2002 Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis. Catecholamines 56-69 tyrosine hydroxylase Homo sapiens 0-20 12113410-1 2002 Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis. Catecholamines 56-69 tyrosine hydroxylase Homo sapiens 22-24 12371054-0 2002 Do catecholamines influence the level of plasma leptin in patients with phaeochromocytoma? Catecholamines 3-17 leptin Homo sapiens 48-54 12371054-1 2002 The relationship between plasma leptin and catecholamine concentrations during chronic and acute catecholamine excess is studied. Catecholamines 43-56 leptin Homo sapiens 32-38 12371054-1 2002 The relationship between plasma leptin and catecholamine concentrations during chronic and acute catecholamine excess is studied. Catecholamines 97-110 leptin Homo sapiens 32-38 27786088-0 2002 Do catecholamines influence the level of plasma leptin in patients with phaeochromocytoma? Catecholamines 3-17 leptin Homo sapiens 48-54 27786088-1 2002 The relationship between plasma leptin and catecholamine concentrations during chronic and acute catecholamine excess is studied. Catecholamines 43-56 leptin Homo sapiens 32-38 27786088-1 2002 The relationship between plasma leptin and catecholamine concentrations during chronic and acute catecholamine excess is studied. Catecholamines 97-110 leptin Homo sapiens 32-38 11849292-0 2002 Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. Catecholamines 6-19 catechol-O-methyltransferase Mus musculus 64-68 11849292-6 2002 This finding is consistent with previous pharmacological studies with COMT inhibitors and confirms the pivotal role of synaptic reuptake processes and monoamine oxidase-dependent metabolism in terminating the actions of catecholamines at nerve terminals. Catecholamines 220-234 catechol-O-methyltransferase Mus musculus 70-74 11884023-4 2001 CD4+ and CD8+ lymphocytes were incubated with catecholamines, interleukin 1beta (IL-1beta) and interleukin 2 (IL-2) for 6-72 h. The results demonstrate declining beta2R numbers on CD4+ and CD8+ lymphocytes in vitro augmented by epinephrine. Catecholamines 46-60 CD4 molecule Homo sapiens 0-3 12858557-0 2002 A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Catecholamines 97-110 calsequestrin 2 Homo sapiens 52-57 11841594-1 2002 We have evaluated the effect of chronic administration of melatonin in terms of mRNA expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, and in the terms of dopamine (DA) transporter (DAT) by means of in situ hybridization. Catecholamines 155-168 tyrosine hydroxylase Rattus norvegicus 122-124 11786596-9 2002 However, the heterogeneity in the response of leptin to catecholamines suggests potential alterations of the leptin axis that may contribute to generate a positive energy balance and, thus, may favor weight gain in some obese individuals. Catecholamines 56-70 leptin Homo sapiens 46-52 11786596-9 2002 However, the heterogeneity in the response of leptin to catecholamines suggests potential alterations of the leptin axis that may contribute to generate a positive energy balance and, thus, may favor weight gain in some obese individuals. Catecholamines 56-70 leptin Homo sapiens 109-115 11799093-5 2002 Tyrosine hydroxylase (TH) is a rate-limiting enzyme involved in the biosynthesis of catecholamine, and this catecholamine synthesis depends both on TH enzyme activity and on the levels of TH protein after TH gene transcription. Catecholamines 84-97 tyrosine hydroxylase Homo sapiens 0-20 11799093-5 2002 Tyrosine hydroxylase (TH) is a rate-limiting enzyme involved in the biosynthesis of catecholamine, and this catecholamine synthesis depends both on TH enzyme activity and on the levels of TH protein after TH gene transcription. Catecholamines 108-121 tyrosine hydroxylase Homo sapiens 0-20 11801260-4 2002 Stress, by activating the sympathetic nervous system, the hypothalamic-pituitary axis, and the renin-angiotensin system, causes the release of various stress hormones such as catecholamines, corticosteroids, glucagon, growth hormone, and renin, and elevated levels of homocysteine, which induce a heightened state of cardiovascular activity, injured endothelium, and induction of adhesion molecules on endothelial cells to which recruited inflammatory cells adhere and translocate to the arterial wall. Catecholamines 175-189 renin Homo sapiens 95-100 12053603-3 2002 In the search of factors that can precipitate degeneration of dopaminergic neurons the role of enzymes catabolising xenobiotics (CYP2D6, NAT2) and enzymes metabolising catecholamines (COMT, MAO B) has been postulated. Catecholamines 168-182 catechol-O-methyltransferase Homo sapiens 184-188 11705783-0 2001 Inhibition of placental 11beta-hydroxysteroid dehydrogenase type 2 by catecholamines via alpha-adrenergic signaling. Catecholamines 70-84 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 24-66 11803531-2 2001 Molecular genetic and pharmacological studies suggest the involvement of dopaminergic and noradrenergic neurotransmitter systems in ADHD, e.g., several reports have found association between ADHD and the dopamine receptor gene DRD-4, the dopamine transporter gene DAT1, and the catecholamine clearance enzyme catechol-O-methyltransferase. Catecholamines 278-291 dopamine receptor D4 Homo sapiens 227-232 11803531-2 2001 Molecular genetic and pharmacological studies suggest the involvement of dopaminergic and noradrenergic neurotransmitter systems in ADHD, e.g., several reports have found association between ADHD and the dopamine receptor gene DRD-4, the dopamine transporter gene DAT1, and the catecholamine clearance enzyme catechol-O-methyltransferase. Catecholamines 278-291 solute carrier family 6 member 3 Homo sapiens 264-268 11803531-2 2001 Molecular genetic and pharmacological studies suggest the involvement of dopaminergic and noradrenergic neurotransmitter systems in ADHD, e.g., several reports have found association between ADHD and the dopamine receptor gene DRD-4, the dopamine transporter gene DAT1, and the catecholamine clearance enzyme catechol-O-methyltransferase. Catecholamines 278-291 catechol-O-methyltransferase Homo sapiens 309-337 11704930-0 2001 A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Catecholamines 97-110 calsequestrin 2 Homo sapiens 52-57 11698243-2 2001 We investigated the ability of the toxic PrP(sc) fragment 106-126 to interfere with evoked catecholamine secretion from PC-12 cells. Catecholamines 91-104 prion protein Rattus norvegicus 41-44 11705783-6 2001 Experiments using different adrenoceptor subtype-selective agonists and antagonists demonstrated that this catecholamine suppression of 11betaHSD2 mRNA expression is mediated via both alpha(1)- and alpha(2)-adrenoceptors and is independent of beta-adrenergic stimulation. Catecholamines 107-120 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 136-146 11739470-6 2001 2) Nicotine elicits a rapid increase in the release of both catecholamines and NPY; this release of NPY is more sustained than that of catecholamines. Catecholamines 60-74 neuropeptide Y Homo sapiens 100-103 11738836-4 2001 Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme for the biosynthesis of catecholamines. Catecholamines 90-104 tyrosine hydroxylase Mus musculus 0-20 11738836-4 2001 Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme for the biosynthesis of catecholamines. Catecholamines 90-104 tyrosine hydroxylase Mus musculus 22-24 11739457-1 2001 The lipolytic effects of catecholamines are mediated through members of the beta(2)-adrenergic receptor (BAR-2) family. Catecholamines 25-39 adrenoceptor beta 2 Homo sapiens 76-103 11739470-0 2001 NPY regulates catecholamine secretion from human adrenal chromaffin cells. Catecholamines 14-27 neuropeptide Y Homo sapiens 0-3 11739470-6 2001 2) Nicotine elicits a rapid increase in the release of both catecholamines and NPY; this release of NPY is more sustained than that of catecholamines. Catecholamines 135-149 neuropeptide Y Homo sapiens 79-82 11739470-1 2001 The aim of the present work was to find out whether NPY synthesized in human adrenal chromaffin cells controls in an autocrine/paracrine fashion the release of catecholamines by these cells. Catecholamines 160-174 neuropeptide Y Homo sapiens 52-55 11739470-10 2001 Taken together, these data suggest that NPY originating from the adrenal medulla locally enhances the secretion of catecholamines, presumably by acting via the putative y3 receptor. Catecholamines 115-129 neuropeptide Y Homo sapiens 40-43 11735087-5 2001 The results indicate that this compound undergoes the action of catechol-O-methyl transferase (COMT), enzymes involved in the catecholamine catabolism, resulting in an enhanced excretion of HVA1c. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 64-93 11752053-1 2001 In cells from the adrenal medulla, angiotensin II (AII) regulates both the activity and mRNA levels of catecholamine biosynthetic enzymes whose expression is thought to be under the control of cAMP-responsive element (CRE) binding protein (CREB). Catecholamines 103-116 cAMP responsive element binding protein 1 Bos taurus 240-244 11735087-5 2001 The results indicate that this compound undergoes the action of catechol-O-methyl transferase (COMT), enzymes involved in the catecholamine catabolism, resulting in an enhanced excretion of HVA1c. Catecholamines 126-139 catechol-O-methyltransferase Homo sapiens 95-99 11701460-2 2001 Catecholamines are also substrates for COMT, and increased levels of catecholamines are associated with vasoocclusive disorders. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 39-43 11780762-13 2001 These observations raise the possibility that some of the biological effects of tea polyphenols may be exerted by their O-methylated products or may result from their potential inhibition of the COMT-catalysed O-methylation of endogenous catecholamines and catechol oestrogens. Catecholamines 238-252 catechol-O-methyltransferase Rattus norvegicus 195-199 11701618-0 2001 beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Catecholamines 111-125 adrenoceptor beta 2 Rattus norvegicus 0-27 11701618-8 2001 These experiments indicate that alveolar beta(2)AR overexpression improves beta(2)AR function and maximally upregulates beta-agonist-responsive active Na(+) transport by improving responsiveness to endogenous catecholamines. Catecholamines 209-223 adrenoceptor beta 2 Rattus norvegicus 41-50 11533051-3 2001 In this study, catecholamine regulation of GSK-3beta was investigated in Rat-1 fibroblasts stably expressing the alpha1A-adrenergic receptor. Catecholamines 15-28 glycogen synthase kinase 3 beta Rattus norvegicus 43-52 11533051-3 2001 In this study, catecholamine regulation of GSK-3beta was investigated in Rat-1 fibroblasts stably expressing the alpha1A-adrenergic receptor. Catecholamines 15-28 adrenoceptor alpha 1A Rattus norvegicus 113-140 11641129-0 2001 Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland. Catecholamines 28-41 adenylate cyclase activating polypeptide 1 Rattus norvegicus 19-24 11641129-1 2001 We elucidated the contribution of endogenous pituitary adenylate cyclase-activating polypeptide (PACAP) to neurally evoked catecholamine secretion from the isolated perfused rat adrenal gland. Catecholamines 123-136 adenylate cyclase activating polypeptide 1 Rattus norvegicus 45-95 11641129-1 2001 We elucidated the contribution of endogenous pituitary adenylate cyclase-activating polypeptide (PACAP) to neurally evoked catecholamine secretion from the isolated perfused rat adrenal gland. Catecholamines 123-136 adenylate cyclase activating polypeptide 1 Rattus norvegicus 97-102 11641129-3 2001 The PACAP-induced catecholamine output responses were inhibited by the PACAP type I receptor antagonist PACAP- (6-38) (30-3,000 nM) but were resistant to the PACAP type II receptor antagonist [Lys1,Pro2,5,Ara3,4,Tyr6]-vasoactive intestinal peptide (LPAT-VIP; 30-3,000 nM). Catecholamines 18-31 adenylate cyclase activating polypeptide 1 Rattus norvegicus 4-9 11641129-3 2001 The PACAP-induced catecholamine output responses were inhibited by the PACAP type I receptor antagonist PACAP- (6-38) (30-3,000 nM) but were resistant to the PACAP type II receptor antagonist [Lys1,Pro2,5,Ara3,4,Tyr6]-vasoactive intestinal peptide (LPAT-VIP; 30-3,000 nM). Catecholamines 18-31 ADCYAP receptor type I Rattus norvegicus 71-92 11641129-3 2001 The PACAP-induced catecholamine output responses were inhibited by the PACAP type I receptor antagonist PACAP- (6-38) (30-3,000 nM) but were resistant to the PACAP type II receptor antagonist [Lys1,Pro2,5,Ara3,4,Tyr6]-vasoactive intestinal peptide (LPAT-VIP; 30-3,000 nM). Catecholamines 18-31 adenylate cyclase activating polypeptide 1 Rattus norvegicus 71-76 11641129-3 2001 The PACAP-induced catecholamine output responses were inhibited by the PACAP type I receptor antagonist PACAP- (6-38) (30-3,000 nM) but were resistant to the PACAP type II receptor antagonist [Lys1,Pro2,5,Ara3,4,Tyr6]-vasoactive intestinal peptide (LPAT-VIP; 30-3,000 nM). Catecholamines 18-31 adenylate cyclase activating polypeptide 1 Rattus norvegicus 71-76 11641129-3 2001 The PACAP-induced catecholamine output responses were inhibited by the PACAP type I receptor antagonist PACAP- (6-38) (30-3,000 nM) but were resistant to the PACAP type II receptor antagonist [Lys1,Pro2,5,Ara3,4,Tyr6]-vasoactive intestinal peptide (LPAT-VIP; 30-3,000 nM). Catecholamines 18-31 vasoactive intestinal peptide Rattus norvegicus 254-257 11641129-5 2001 PACAP-(6-38) (3,000 nM), but not LPAT-VIP, also inhibited the ES-induced catecholamine output responses. Catecholamines 73-86 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 11641129-7 2001 PACAP at low concentrations (0.3-3 nM), which had no influence on catecholamine output, enhanced the ACh-induced catecholamine output responses, but not the ES-induced catecholamine output responses. Catecholamines 113-126 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 11641129-7 2001 PACAP at low concentrations (0.3-3 nM), which had no influence on catecholamine output, enhanced the ACh-induced catecholamine output responses, but not the ES-induced catecholamine output responses. Catecholamines 113-126 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 11641129-8 2001 These results suggest that PACAP is released from the nerve endings to facilitate the neurally evoked catecholamine secretion through PACAP type I receptors in the rat adrenal gland. Catecholamines 102-115 adenylate cyclase activating polypeptide 1 Rattus norvegicus 27-32 11641129-8 2001 These results suggest that PACAP is released from the nerve endings to facilitate the neurally evoked catecholamine secretion through PACAP type I receptors in the rat adrenal gland. Catecholamines 102-115 adenylate cyclase activating polypeptide 1 Rattus norvegicus 134-139 11723224-4 2001 An extensive pharmacological survey revealed that psychostimulant and hallucinogenic amphetamines, numerous ergoline derivatives, adrenergic ligands, and 3-methylated metabolites of the catecholamine neurotransmitters are also good agonists at the rat trace amine receptor 1 (rTAR1). Catecholamines 186-199 trace-amine-associated receptor 1 Rattus norvegicus 276-281 11581251-2 2001 Evidence suggests that catecholamines not only can activate PKA, but also the mitogen-activated protein kinase pathway and extracellular signal-regulated kinase (ERK). Catecholamines 23-37 mitogen-activated protein kinase 1 Mus musculus 123-160 11581251-2 2001 Evidence suggests that catecholamines not only can activate PKA, but also the mitogen-activated protein kinase pathway and extracellular signal-regulated kinase (ERK). Catecholamines 23-37 mitogen-activated protein kinase 1 Mus musculus 162-165 11581251-3 2001 We now demonstrate that two different inhibitors of MEK, the upstream activator of ERK, block catecholamine- and beta(3)-stimulated lipolysis by approximately 30%. Catecholamines 94-107 mitogen-activated protein kinase 1 Mus musculus 83-86 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Catecholamines 232-245 glutathione S-transferase mu 1 Homo sapiens 40-68 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Catecholamines 232-245 glutathione S-transferase mu 1 Homo sapiens 70-75 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Catecholamines 232-245 NAD(P)H quinone dehydrogenase 1 Homo sapiens 78-110 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Catecholamines 232-245 NAD(P)H quinone dehydrogenase 1 Homo sapiens 112-116 11701460-3 2001 We hypothesize that catecholamines may abrogate the vasoprotective effects of 2-hydroxyestradiol by competing for COMT and inhibiting 2-methoxyestradiol formation. Catecholamines 20-34 catechol-O-methyltransferase Homo sapiens 114-118 11606454-0 2001 Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells. Catecholamines 18-31 leptin Mus musculus 0-6 11606454-0 2001 Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells. Catecholamines 18-31 protein kinase C, epsilon Mus musculus 47-50 11606454-1 2001 We have previously shown that murine recombinant leptin directly stimulates catecholamine synthesis through the long form of the leptin receptor (Ob-Rb) expressed in cultured porcine chromaffin cells. Catecholamines 76-89 leptin Mus musculus 49-55 11606454-1 2001 We have previously shown that murine recombinant leptin directly stimulates catecholamine synthesis through the long form of the leptin receptor (Ob-Rb) expressed in cultured porcine chromaffin cells. Catecholamines 76-89 leptin receptor Mus musculus 129-144 11606454-4 2001 Therefore, we investigated the involvement of PKC in leptin-induced catecholamine synthesis. Catecholamines 68-81 leptin Mus musculus 53-59 11606454-7 2001 The activity of the rate-limiting enzyme tyrosine hydroxylase (TH) in the biosynthesis of catecholamine is regulated at the transcriptional and posttranscriptional levels. Catecholamines 90-103 tyrosine hydroxylase Mus musculus 41-61 11606454-9 2001 In addition, increases in TH protein and intracellular catecholamine content stimulated by leptin were completely inhibited by Ro 32-0432. Catecholamines 55-68 leptin Mus musculus 91-97 11606454-16 2001 These results indicate that leptin stimulates Ca(2+)-dependent PKC isoform-dependent catecholamine synthesis in porcine chromaffin cells. Catecholamines 85-98 leptin Mus musculus 28-34 11606454-16 2001 These results indicate that leptin stimulates Ca(2+)-dependent PKC isoform-dependent catecholamine synthesis in porcine chromaffin cells. Catecholamines 85-98 protein kinase C, epsilon Mus musculus 63-66 11606454-19 2001 Consistent with this finding, leptin is shown here to activate novel PKC epsilon, which is assumed to stimulate Raf, upstream of ERKs, via cAMP, supporting the suggestion that Ca(2+)-independent novel PKC may also play some physiological role in regulating catecholamine synthesis. Catecholamines 257-270 leptin Mus musculus 30-36 11606454-19 2001 Consistent with this finding, leptin is shown here to activate novel PKC epsilon, which is assumed to stimulate Raf, upstream of ERKs, via cAMP, supporting the suggestion that Ca(2+)-independent novel PKC may also play some physiological role in regulating catecholamine synthesis. Catecholamines 257-270 protein kinase C, epsilon Mus musculus 69-80 11606454-19 2001 Consistent with this finding, leptin is shown here to activate novel PKC epsilon, which is assumed to stimulate Raf, upstream of ERKs, via cAMP, supporting the suggestion that Ca(2+)-independent novel PKC may also play some physiological role in regulating catecholamine synthesis. Catecholamines 257-270 protein kinase C, epsilon Mus musculus 69-72 11764279-8 2001 On the other hand, mice carrying the mutation in the gene encoding tyrosine hydroxylase (the rate-limiting enzyme of catecholamine biosynthesis) display a reduction in norepinephrine biosynthesis. Catecholamines 117-130 tyrosine hydroxylase Mus musculus 67-87 11702234-5 2001 Most of them coexpressed the low affinity neurotrophin receptor (p75NTR), and some were catecholaminergic, as determined by their content of immunoreactive tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 178-180 11753577-1 2001 BACKGROUND: The beta1-adrenoceptor is a candidate gene for obesity because of its role in catecholamine-induced energy homeostasis. Catecholamines 90-103 adrenoceptor beta 1 Homo sapiens 16-34 11753577-3 2001 OBJECTIVE: To investigate the effect of the Arg 389 Gly beta1-adrenoceptor polymorphism on catecholamine-induced lipolysis in native human fat cells obtained by subcutaneous biopsy. Catecholamines 91-104 adrenoceptor beta 1 Homo sapiens 56-74 11677361-10 2001 Thus, ETA receptor antagonists may help to regress large artery remodeling in conditions of increased circulating catecholamine concentrations. Catecholamines 114-127 endothelin receptor type A Rattus norvegicus 6-9 11702234-5 2001 Most of them coexpressed the low affinity neurotrophin receptor (p75NTR), and some were catecholaminergic, as determined by their content of immunoreactive tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 88-101 tyrosine hydroxylase Homo sapiens 156-176 11701744-1 2001 Catecholamines have been shown to modulate gonadal functions via interactions with hypothalamic LH-releasing hormone (LHRH)-synthesizing neurons. Catecholamines 0-14 gonadotropin releasing hormone 1 Homo sapiens 96-116 11701744-1 2001 Catecholamines have been shown to modulate gonadal functions via interactions with hypothalamic LH-releasing hormone (LHRH)-synthesizing neurons. Catecholamines 0-14 gonadotropin releasing hormone 1 Homo sapiens 118-122 11735324-0 2001 Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase (COMT) estimated by enzyme kinetic values. Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 68-96 11735324-0 2001 Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase (COMT) estimated by enzyme kinetic values. Catecholamines 0-13 catechol-O-methyltransferase Homo sapiens 98-102 11641423-2 2001 In addition to their prominent function in the heart, beta-AR are located on vascular smooth muscle cells, where they mediate vasodilating effects of endogenous catecholamines. Catecholamines 161-175 adrenergic receptor, beta 1 Mus musculus 54-61 11684087-3 2001 To clarify whether catecholamines might exert their insulin resistance-inducing effects at least partly via downregulation of adiponectin gene expression, 3T3-L1 adipocytes were treated with isoproterenol, and adiponectin mRNA was measured by quantitative real-time reverse transcription-polymerase chain reaction. Catecholamines 19-33 adiponectin, C1Q and collagen domain containing Mus musculus 126-137 11699042-5 2001 Thus, the decrease in response to catecholamines found on litter removal from lactating rats appears to be due to a diminished ability to activate HSL associated with fat droplet. Catecholamines 34-48 lipase E, hormone sensitive type Rattus norvegicus 147-150 11754978-4 2001 PAMP and PAMP12 regulate catecholamine release and synthesis by interfering with nicotinic cholinergic receptors in these chromaffin cells. Catecholamines 25-38 adrenomedullin Homo sapiens 0-4 11684087-8 2001 The data support a possible role of adiponectin in catecholamine-induced insulin resistance. Catecholamines 51-64 adiponectin, C1Q and collagen domain containing Mus musculus 36-47 11600547-7 2001 Collectively, these findings suggest that orexins stimulate catecholamine secretion from human pheochromocytomas, acting through OX2-R coupled to the PLC-PKC signaling pathway. Catecholamines 60-73 hypocretin receptor 2 Homo sapiens 129-134 11597779-9 2001 Although altered catecholamine activity due to polymorphism of COMT gene may be one of the mechanisms involved in the pathogenesis of migraine, these mechanisms are not related to presence or absence of aura. Catecholamines 17-30 catechol-O-methyltransferase Homo sapiens 63-67 11604549-8 2001 Because of these differences, selective activation of cardiac beta2AR may provide catecholamine-dependent inotropic support without cardiotoxic consequences, which might have beneficial effects in the failing heart. Catecholamines 82-95 adrenergic receptor, beta 2 Mus musculus 62-69 11533551-6 2001 Factors that can determine ANF secretion abnormality in MVP could be: 1) Mitral regurgitation; 2) increased heart rate and the high incidence, in MVP syndrome, of arrhythmias; 3) central nervous system neuroendocrine imbalance; 4) increased catecholamines secretion. Catecholamines 241-255 natriuretic peptide A Homo sapiens 27-30 11593096-5 2001 In contrast, TH AS ODN (200 microg/rat) had no effect on SBP in Wistar-Kyoto rats (WKY), despite significantly decreased catecholamine levels, TH activity, and TH protein levels. Catecholamines 121-134 tyrosine hydroxylase Rattus norvegicus 13-15 11725722-4 2001 Catecholamines inhibit leptin production and the sympathetic nervous system has been proposed to be the efferent arm of the leptin signal transduction pathway between adipose tissue and the central nervous system. Catecholamines 0-14 leptin Homo sapiens 124-130 12030814-2 2001 In the present study we examined the influence of CART peptide fragment, CART(62-76), on the levels of catecholamines (dopamine and norepinephrine), serotonin and their metabolites in five regions of the rat brain. Catecholamines 103-117 CART prepropeptide Rattus norvegicus 50-54 12030814-2 2001 In the present study we examined the influence of CART peptide fragment, CART(62-76), on the levels of catecholamines (dopamine and norepinephrine), serotonin and their metabolites in five regions of the rat brain. Catecholamines 103-117 CART prepropeptide Rattus norvegicus 73-77 11591352-11 2001 The proposed evolutionary pathway implies that adrenaline, the product of PNMT catalysis, is a relative newcomer in the catecholamine family. Catecholamines 120-133 phenylethanolamine N-methyltransferase Homo sapiens 74-78 11725722-4 2001 Catecholamines inhibit leptin production and the sympathetic nervous system has been proposed to be the efferent arm of the leptin signal transduction pathway between adipose tissue and the central nervous system. Catecholamines 0-14 leptin Homo sapiens 23-29 11546977-14 2001 Because AT2 receptors are thought to be involved in adrenal catecholamine secretion in a stimulatory fashion, the diminished expression of AT2 receptors could play an important role in the pathogenesis of septic shock via impaired angiotensin II-induced adrenal catecholamine release, despite a strong activation of the systemic renin-angiotensin system. Catecholamines 60-73 angiotensin II receptor, type 2 Rattus norvegicus 8-11 11546977-14 2001 Because AT2 receptors are thought to be involved in adrenal catecholamine secretion in a stimulatory fashion, the diminished expression of AT2 receptors could play an important role in the pathogenesis of septic shock via impaired angiotensin II-induced adrenal catecholamine release, despite a strong activation of the systemic renin-angiotensin system. Catecholamines 60-73 angiotensinogen Rattus norvegicus 231-245 11546977-2 2001 This has focused interest in regulation of the adrenal angiotensin II type 2 receptor (AT2) as the target thought to mediate angiotensin II-induced adrenal catecholamine release during experimental sepsis in vivo. Catecholamines 156-169 angiotensin II receptor, type 2 Rattus norvegicus 55-85 11546977-2 2001 This has focused interest in regulation of the adrenal angiotensin II type 2 receptor (AT2) as the target thought to mediate angiotensin II-induced adrenal catecholamine release during experimental sepsis in vivo. Catecholamines 156-169 angiotensin II receptor, type 2 Rattus norvegicus 87-90 11546977-2 2001 This has focused interest in regulation of the adrenal angiotensin II type 2 receptor (AT2) as the target thought to mediate angiotensin II-induced adrenal catecholamine release during experimental sepsis in vivo. Catecholamines 156-169 angiotensinogen Rattus norvegicus 55-69 11546977-14 2001 Because AT2 receptors are thought to be involved in adrenal catecholamine secretion in a stimulatory fashion, the diminished expression of AT2 receptors could play an important role in the pathogenesis of septic shock via impaired angiotensin II-induced adrenal catecholamine release, despite a strong activation of the systemic renin-angiotensin system. Catecholamines 262-275 angiotensin II receptor, type 2 Rattus norvegicus 139-142 11546977-14 2001 Because AT2 receptors are thought to be involved in adrenal catecholamine secretion in a stimulatory fashion, the diminished expression of AT2 receptors could play an important role in the pathogenesis of septic shock via impaired angiotensin II-induced adrenal catecholamine release, despite a strong activation of the systemic renin-angiotensin system. Catecholamines 262-275 angiotensinogen Rattus norvegicus 231-245 11504807-4 2001 The decreased baseline immobility in 5-HT(1A) receptor mutant mice was reversed by pretreatment with alpha-methyl-para-tyrosine, but not by para-chlorophenylalanine, suggesting mediation by enhanced catecholamine function. Catecholamines 199-212 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 37-54 11517010-8 2001 The increase in catecholamines was followed by a quick and significant decrease in serum leptin levels 45 min after an i.v. Catecholamines 16-30 leptin Homo sapiens 89-95 11517010-13 2001 In conclusion, an acute increase in endogenous circulating catecholamines is associated with a quick decrease in serum leptin levels. Catecholamines 59-73 leptin Homo sapiens 119-125 11494052-0 2001 Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland. Catecholamines 145-158 calcitonin-related polypeptide alpha Rattus norvegicus 0-31 11494052-0 2001 Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland. Catecholamines 145-158 calcitonin-related polypeptide alpha Rattus norvegicus 33-37 11494052-2 2001 CGRP belongs to a regulatory-peptide family, that includes adrenomedullin (ADM) whose aldosterone antisecretagogue and catecholamine secretagogue actions are well demonstrated. Catecholamines 119-132 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 11494052-5 2001 CGRP concentration-dependently inhibited 10 mM-stimulated (but not basal) aldosterone secretion from dispersed rat ZG cells, and enhanced basal catecholamine secretion from rat adrenomedullary fragments. Catecholamines 144-157 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 11494052-8 2001 The conclusion is drawn that CGRP, like ADM, inhibits agonist-stimulated aldosterone secretion and stimulates basal catecholamine release in the rat, exclusively acting via CGRP1 receptors. Catecholamines 116-129 calcitonin-related polypeptide alpha Rattus norvegicus 29-33 11492989-2 2001 METHODS AND RESULTS: In 10 patients with idiopathic dilated cardiomyopathy, presynaptic catecholamine uptake sites were quantified by positron emission tomography with C-11 hydroxyephedrine. Catecholamines 88-101 RNA polymerase III subunit K Homo sapiens 168-172 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Catecholamines 15-29 hemoglobin, beta adult major chain Mus musculus 292-298 11502876-0 2001 A Na(+)/Cl(-)-dependent transporter for catecholamines, identified as a norepinephrine transporter, is expressed in the brain of the teleost fish medaka (Oryzias latipes). Catecholamines 40-54 solute carrier family 6 member 2 Homo sapiens 72-98 11418593-1 2001 Dopamine beta-monooxygenase (DBM) and peptidylglycine alpha-hydroxylating monooxygenase (PHM) are essential for the biosynthesis of catecholamines and amidated peptides, respectively. Catecholamines 132-146 dopamine beta hydroxylase Mus musculus 0-27 11702062-4 2001 In addition to identifying both the phenotype and the associated mutation found by Brunner et al., we also wished to test the hypothesis that mutations elsewhere in the MAO-A gene could cause the low intelligence quotient/personality disorder phenotype associated with low urinary catecholamine degradation products. Catecholamines 281-294 monoamine oxidase A Homo sapiens 169-174 11520498-1 2001 Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10]. Catecholamines 204-217 fibroblast growth factor 1 Homo sapiens 61-87 11520498-1 2001 Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10]. Catecholamines 204-217 tyrosine hydroxylase Homo sapiens 238-258 11520498-1 2001 Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10]. Catecholamines 204-217 tyrosine hydroxylase Homo sapiens 260-262 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Catecholamines 15-29 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mus musculus 180-188 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Catecholamines 15-29 hemoglobin, beta adult minor chain Mus musculus 300-314 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Catecholamines 15-29 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 190-198 11677796-9 2001 Both presynaptic alpha 2-receptors are essential, as deletion of alpha 2A- and alpha 2C-receptors leads to cardiac hypertrophy and failure due to chronically enhanced catecholamine release. Catecholamines 167-180 adrenergic receptor, alpha 2a Mus musculus 65-73 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Catecholamines 15-29 adrenergic receptor, alpha 2a Mus musculus 236-244 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Catecholamines 15-29 adrenergic receptor, alpha 2b Mus musculus 246-254 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Catecholamines 15-29 adrenergic receptor, alpha 2c Mus musculus 256-264 11677796-9 2001 Both presynaptic alpha 2-receptors are essential, as deletion of alpha 2A- and alpha 2C-receptors leads to cardiac hypertrophy and failure due to chronically enhanced catecholamine release. Catecholamines 167-180 adrenergic receptor, alpha 2c Mus musculus 79-87 11489441-2 2001 Evidence from immunological studies demonstrates that substance P-immunoreactive neurons in the LH project near the A7 catecholamine cell group, a group of noradrenergic neurons in the pons known to effect antinociception in the spinal cord dorsal horn. Catecholamines 119-132 tachykinin precursor 1 Homo sapiens 54-65 11504916-4 2001 In mice, adenoviral gene transfer of the JNK binding domain of JNK-interacting protein-1 (a scaffold protein and inhibitor of JNK) inhibited this cascade downstream of MKK4 phosphorylation, blocked JNK, c-Jun, and caspase activation, the death of dopaminergic neurons, and the loss of catecholamines in the striatum. Catecholamines 285-299 mitogen-activated protein kinase 8 Homo sapiens 41-44 11504916-4 2001 In mice, adenoviral gene transfer of the JNK binding domain of JNK-interacting protein-1 (a scaffold protein and inhibitor of JNK) inhibited this cascade downstream of MKK4 phosphorylation, blocked JNK, c-Jun, and caspase activation, the death of dopaminergic neurons, and the loss of catecholamines in the striatum. Catecholamines 285-299 mitogen-activated protein kinase 8 interacting protein 1 Mus musculus 63-88 11504916-4 2001 In mice, adenoviral gene transfer of the JNK binding domain of JNK-interacting protein-1 (a scaffold protein and inhibitor of JNK) inhibited this cascade downstream of MKK4 phosphorylation, blocked JNK, c-Jun, and caspase activation, the death of dopaminergic neurons, and the loss of catecholamines in the striatum. Catecholamines 285-299 mitogen-activated protein kinase 8 Mus musculus 63-66 11504916-4 2001 In mice, adenoviral gene transfer of the JNK binding domain of JNK-interacting protein-1 (a scaffold protein and inhibitor of JNK) inhibited this cascade downstream of MKK4 phosphorylation, blocked JNK, c-Jun, and caspase activation, the death of dopaminergic neurons, and the loss of catecholamines in the striatum. Catecholamines 285-299 mitogen-activated protein kinase 8 Mus musculus 63-66 11502905-0 2001 Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism. Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 79-83 11483239-11 2001 Mint1 intensely stained catecholamine-containing neurons such as the substantia nigra pars compacta, ventral tegmental area, and locus ceruleus. Catecholamines 24-37 amyloid beta (A4) precursor protein binding, family A, member 1 Mus musculus 0-5 11532988-3 2001 The TH gene encodes the rate-limiting enzyme in the synthesis of catecholamines, and the microsatellite HUMTH01 has been used in genetic studies of neuropsychiatric and cardiovascular diseases, in which disturbances of catecholaminergic neurotransmission have been implicated. Catecholamines 65-79 tyrosine hydroxylase Homo sapiens 4-6 11476743-9 2001 When adrenergic vasopressors were unable to maintain arterial blood pressure in patients with vasodilatory shock, continuous infusions of vasopressin ( approximately 0.04 to approximately 0.1 U/min) stabilised cardiocirculatory parameters, and even ensured weaning from catecholamines. Catecholamines 270-284 arginine vasopressin Homo sapiens 138-149 11532994-8 2001 These findings from sequence analysis lead to a prediction that stromal cell-derived receptor 2 is a catecholamine-regulated ferric reductase active in the brain. Catecholamines 101-114 ferric-chelate reductase 1 Mus musculus 64-95 11502905-3 2001 One etiologic hypothesis for this condition is that deletion of the COMT gene from one chromosome 22 results in increased catecholamine neurotransmission, particularly if the undeleted chromosome 22 encodes a variant of COMT with low activity. Catecholamines 122-135 catechol-O-methyltransferase Homo sapiens 68-72 11502905-3 2001 One etiologic hypothesis for this condition is that deletion of the COMT gene from one chromosome 22 results in increased catecholamine neurotransmission, particularly if the undeleted chromosome 22 encodes a variant of COMT with low activity. Catecholamines 122-135 catechol-O-methyltransferase Homo sapiens 220-224 11448853-0 2001 Role of calcium channels and adenylate cyclase in the PACAP-induced adrenal catecholamine secretion. Catecholamines 76-89 adenylate cyclase activating polypeptide 1 Rattus norvegicus 54-59 11395511-9 2001 PTP1B appears to be a critical point for insulin and catecholamine counter-regulation. Catecholamines 53-66 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 0-5 11468403-1 2001 Mammalian GTP cyclohydrolase I is a decameric enzyme in the first and rate-limiting step in the biosynthesis of tetrahydrobiopterin, which is an essential cofactor for enzymes producing neurotransmitters such as catecholamines and for nitric oxide synthases. Catecholamines 212-226 GTP cyclohydrolase 1 Homo sapiens 10-30 11473556-2 2001 Both types of stress evoke - mainly by release of catecholamines - leukocytosis resulting from a release of natural killer cells (NK-cells), of CD8+ T-cells, of monocytes and of neutrophils. Catecholamines 50-64 CD8a molecule Homo sapiens 144-147 11448853-5 2001 Treatment with nifedipine and MDL-12330A caused additive inhibition of the PACAP-induced catecholamine responses. Catecholamines 89-102 adenylate cyclase activating polypeptide 1 Rattus norvegicus 75-80 11448853-6 2001 These results suggest that opening of L-type VDCCs is responsible for adrenal catecholamine secretion induced by PACAP and that activation of adenylate cyclase is involved in the PACAP-induced Epi, but not NE, secretion. Catecholamines 78-91 adenylate cyclase activating polypeptide 1 Rattus norvegicus 113-118 11499749-0 2001 Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. Catecholamines 48-61 G protein-coupled receptor kinase 2 Mus musculus 25-33 11511958-13 2001 CONCLUSIONS: In this group of patients with severe septic shock, vasopressin infusion increased MAP and urine output and decreased catecholamine requirements. Catecholamines 131-144 arginine vasopressin Homo sapiens 65-76 11494094-1 2001 A deficient dopamine D(2) receptor (DA2) formation or action may contribute to hypertension via an increase of catecholamine release. Catecholamines 111-124 dopamine receptor D2 Homo sapiens 12-34 11494094-1 2001 A deficient dopamine D(2) receptor (DA2) formation or action may contribute to hypertension via an increase of catecholamine release. Catecholamines 111-124 dopamine receptor D2 Homo sapiens 36-39 11483656-0 2001 L-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells. Catecholamines 101-114 tyrosine hydroxylase Homo sapiens 60-80 11461172-8 2001 Beta-adrenergic activity suppresses transcription of LPL in adipocytes; this phenomenon may contribute to the favorable impact of exercise training on visceral obesity; conceivably, preadministration of safe drugs that boost catecholamine activity (caffeine, yohimbine) could potentiate this beneficial effect of exercise. Catecholamines 225-238 lipoprotein lipase Homo sapiens 53-56 11342539-1 2001 Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. Catecholamines 73-86 chromogranin A Homo sapiens 45-48 11342539-2 2001 Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for regulating catecholamine responses during stress. Catecholamines 51-64 chromogranin A Homo sapiens 0-14 11342539-2 2001 Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for regulating catecholamine responses during stress. Catecholamines 51-64 chromogranin A Homo sapiens 16-19 11342539-2 2001 Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for regulating catecholamine responses during stress. Catecholamines 159-172 chromogranin A Homo sapiens 0-14 11342539-2 2001 Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for regulating catecholamine responses during stress. Catecholamines 159-172 chromogranin A Homo sapiens 16-19 11342539-2 2001 Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for regulating catecholamine responses during stress. Catecholamines 159-172 chromogranin A Homo sapiens 0-14 11342539-2 2001 Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for regulating catecholamine responses during stress. Catecholamines 159-172 chromogranin A Homo sapiens 16-19 11342539-4 2001 Recently, we found that chromaffin cells express components of the plasmin(ogen) system, including tissue plasminogen activator, which is targeted to catecholamine storage vesicles and released with CgA and catecholamines in response to sympathoadrenal stimulation, and high affinity cell surface receptors for plasminogen, to promote plasminogen activation at the cell surface. Catecholamines 150-163 plasminogen Homo sapiens 67-74 11342539-4 2001 Recently, we found that chromaffin cells express components of the plasmin(ogen) system, including tissue plasminogen activator, which is targeted to catecholamine storage vesicles and released with CgA and catecholamines in response to sympathoadrenal stimulation, and high affinity cell surface receptors for plasminogen, to promote plasminogen activation at the cell surface. Catecholamines 207-221 plasminogen Homo sapiens 67-74 11342539-11 2001 These results identify plasmin as a protease, present in the local environment of the chromaffin cell, that selectively cleaves CgA to generate a bioactive fragment, hCgA-(360-373), that inhibits nicotinic-mediated catecholamine release. Catecholamines 215-228 plasminogen Homo sapiens 23-30 11342539-11 2001 These results identify plasmin as a protease, present in the local environment of the chromaffin cell, that selectively cleaves CgA to generate a bioactive fragment, hCgA-(360-373), that inhibits nicotinic-mediated catecholamine release. Catecholamines 215-228 chromogranin A Homo sapiens 128-131 11342539-11 2001 These results identify plasmin as a protease, present in the local environment of the chromaffin cell, that selectively cleaves CgA to generate a bioactive fragment, hCgA-(360-373), that inhibits nicotinic-mediated catecholamine release. Catecholamines 215-228 chromogranin A Homo sapiens 166-170 11440283-2 2001 Much of this degradation is produced by catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines and catechol compounds. Catecholamines 117-131 catechol-O-methyltransferase Homo sapiens 40-68 11404280-12 2001 The cold-induced changes in cytokine expression appear to be linked to enhanced catecholamine secretion associated with cold exposure. Catecholamines 80-93 TNF receptor superfamily member 8 Homo sapiens 28-36 11406463-0 2001 Catecholamines stimulate interleukin-6 synthesis in rat cardiac fibroblasts. Catecholamines 0-14 interleukin 6 Rattus norvegicus 25-38 11525126-4 2001 We propose a hypothesis that the effect of alcohol dehydrogenase on alcohol consumption is connected with its role in catecholamine metabolism. Catecholamines 118-131 aldo-keto reductase family 1 member A1 Rattus norvegicus 43-64 11707293-2 2001 In mammals, neuronal uptake of catecholamines involves the dopamine transporter (DAT) at dopaminergic neurons and the norepinephrine transporter (NET) at noradrenergic neurons. Catecholamines 31-45 solute carrier family 6 member 3 Homo sapiens 59-79 11707293-2 2001 In mammals, neuronal uptake of catecholamines involves the dopamine transporter (DAT) at dopaminergic neurons and the norepinephrine transporter (NET) at noradrenergic neurons. Catecholamines 31-45 solute carrier family 6 member 3 Homo sapiens 81-84 11707293-2 2001 In mammals, neuronal uptake of catecholamines involves the dopamine transporter (DAT) at dopaminergic neurons and the norepinephrine transporter (NET) at noradrenergic neurons. Catecholamines 31-45 solute carrier family 6 member 2 Homo sapiens 118-144 11375525-1 2001 Catechol-O-methyltransferase (COMT) is involved in the metabolism of catecholamines, catechol steroids and xenobiotic catechols. Catecholamines 69-83 catechol-O-methyltransferase Rattus norvegicus 0-28 11375525-1 2001 Catechol-O-methyltransferase (COMT) is involved in the metabolism of catecholamines, catechol steroids and xenobiotic catechols. Catecholamines 69-83 catechol-O-methyltransferase Rattus norvegicus 30-34 11356380-1 2001 Long-term increases in catecholamine release result in elevated levels of the mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of these compounds. Catecholamines 23-36 tyrosine hydroxylase Rattus norvegicus 87-107 11356380-1 2001 Long-term increases in catecholamine release result in elevated levels of the mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of these compounds. Catecholamines 23-36 tyrosine hydroxylase Rattus norvegicus 109-111 11436522-6 2001 When adrenergic vasopressors were unable to maintain arterial blood pressure in patients with vasodilatory shock, continuous infusions of vasopressin (0.04-0.10 U/min) stabilized cardiocirculatory parameters and even ensured weaning from catecholamines. Catecholamines 238-252 arginine vasopressin Homo sapiens 138-149 11429329-0 2001 The effects of vasopressin on systemic hemodynamics in catecholamine-resistant septic and postcardiotomy shock: a retrospective analysis. Catecholamines 55-68 arginine vasopressin Homo sapiens 15-26 11429395-12 2001 This suggests that genetic variance in the beta(2)-adrenoceptor gene might be important for catecholamine function in humans, at least as far as adipocyte lipolysis is concerned. Catecholamines 92-105 adrenoceptor beta 2 Homo sapiens 43-63 11401575-0 2001 Effects of substitution at serine 40 of tyrosine hydroxylase on catecholamine binding. Catecholamines 64-77 tyrosine hydroxylase Homo sapiens 40-60 11401575-1 2001 Phosphorylation of Ser40 in the regulatory domain of tyrosine hydroxylase activates the enzyme by increasing the rate of dissociation of inhibitory catecholamines [Ramsey, A. J., and Fitzpatrick, P. F. (1998) Biochemistry 37, 8980-8986]. Catecholamines 148-162 tyrosine hydroxylase Homo sapiens 53-73 11440283-2 2001 Much of this degradation is produced by catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines and catechol compounds. Catecholamines 117-131 catechol-O-methyltransferase Homo sapiens 70-74 11336641-0 2001 Inhibition of neuronal nitric oxide synthase by 6-nitrocatecholamines, putative reaction products of nitric oxide with catecholamines under oxidative stress conditions. Catecholamines 55-69 nitric oxide synthase 1 Homo sapiens 14-44 11441906-0 2001 Central and peripheral catecholamines regulate the exercise-induced elevation of plasma interleukin 6 in rats. Catecholamines 23-37 interleukin 6 Rattus norvegicus 88-101 11441906-6 2001 These results thus suggest that central and peripheral catecholamines are involved in the regulation of the exercise-induced interleukin 6 elevation. Catecholamines 55-69 interleukin 6 Rattus norvegicus 125-138 11470313-4 2001 Furthermore, copper is a constituent of dopamine-beta-hydroxylase, a critical enzyme in the catecholamine biosynthetic pathway. Catecholamines 92-105 dopamine beta-hydroxylase Homo sapiens 40-65 11342654-4 2001 Inhibition of iNOS restored the normal catecholamine-mediated up-regulation of alveolar liquid clearance. Catecholamines 39-52 nitric oxide synthase 2 Rattus norvegicus 14-18 11331373-6 2001 The results indicate that pituitary hormones can adapt the mechanics of adrenal catecholamine release by tailoring BK channel function. Catecholamines 80-93 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 115-125 11342654-6 2001 Pretreatment with pyrrolidine dithiocarbamate or sulfasalazine attenuated the iNOS-dependent production of NO in the lung and restored the normal up-regulation of alveolar fluid clearance by catecholamines after prolonged hemorrhagic shock. Catecholamines 191-205 nitric oxide synthase 2 Rattus norvegicus 78-82 11394305-7 2001 The proposed method is thought to be useful for the measurement of both S-COMT and MB-COMT activities, and would give us critical information on the role of metabolism of catecholamines in rat tissues. Catecholamines 171-185 catechol-O-methyltransferase Rattus norvegicus 74-78 11354486-4 2001 Catecholamine derivatives had higher retention times on poly(IPAAm-co-AAc) columns at higher pH in comparison with those on noncharged PIPAAm reference columns, suggesting an electrostatic interaction as a separation mode. Catecholamines 0-13 glycine-N-acyltransferase Homo sapiens 70-73 11394305-7 2001 The proposed method is thought to be useful for the measurement of both S-COMT and MB-COMT activities, and would give us critical information on the role of metabolism of catecholamines in rat tissues. Catecholamines 171-185 catechol-O-methyltransferase Rattus norvegicus 86-90 11396718-2 2001 We investigated, by immunocytochemistry in the brain of male and female canaries, the distribution of tyrosine hydroxylase (TH), the rate-limiting step in the synthesis of catecholamines. Catecholamines 172-186 tyrosine 3-monooxygenase Serinus canaria 102-122 11403679-6 2001 The compounds inhibited the catecholamine-induced thioredoxin reductase inhibition, thiol oxidation and carbonyl formation in mitochondria and synaptosomes. Catecholamines 28-41 peroxiredoxin 5 Rattus norvegicus 50-71 11488255-34 2001 AVP might be responsible for an increased catecholamine activity. Catecholamines 42-55 arginine vasopressin Homo sapiens 0-3 11266507-6 2001 In contrast, the catecholamine-evoked GR enhancement was strongly reduced by wortmannin, suggesting a critical role for phosphoinositide 3-kinase (PI3-K). Catecholamines 17-30 nuclear receptor subfamily 3 group C member 1 Homo sapiens 38-40 11278415-1 2001 Annexin 7, a Ca(2+)/GTP-activated membrane fusion protein, is preferentially phosphorylated in intact chromaffin cells, and the levels of annexin 7 phosphorylation increase quantitatively in proportion to the extent of catecholamine secretion. Catecholamines 219-232 annexin A7 Homo sapiens 0-9 11358931-2 2001 Several possibilities have been proposed, including heart rate reduction, beta2-adrenoceptor-mediated modulation of catecholamine release, antagonism of the receptor-mediated toxic actions of norepinephrine on the myocardium, and favorable effects on myocardial energetics. Catecholamines 116-129 adrenoceptor beta 2 Homo sapiens 74-92 11344198-1 2001 This study examined the mechanisms linking different biochemical and clinical phenotypes of pheochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) and von Hippel-Lindau (VHL) syndrome to underlying differences in the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, and of phenylethanolamine N-methyltransferase (PNMT), the enzyme that converts norepinephrine to epinephrine. Catecholamines 295-308 tyrosine hydroxylase Homo sapiens 240-260 11311882-7 2001 Of several amino acids tested, only the catecholamine precursor tyrosine had an effect on leptin transport. Catecholamines 40-53 leptin Homo sapiens 90-96 11311236-6 2001 These results suggested that catecholamines up-regulate UCP2 and UCP3 expression through direct action on the beta2-AR in skeletal muscle. Catecholamines 29-43 uncoupling protein 2 Homo sapiens 56-60 11311236-6 2001 These results suggested that catecholamines up-regulate UCP2 and UCP3 expression through direct action on the beta2-AR in skeletal muscle. Catecholamines 29-43 uncoupling protein 3 Homo sapiens 65-69 11311236-6 2001 These results suggested that catecholamines up-regulate UCP2 and UCP3 expression through direct action on the beta2-AR in skeletal muscle. Catecholamines 29-43 adrenoceptor beta 2 Homo sapiens 110-118 11254472-7 2001 It involves both the MR and/or the glucocorticoid receptor (GR), depending on the retinoic or catecholamine induction pathway. Catecholamines 94-107 nuclear receptor subfamily 3, group C, member 1 Mus musculus 35-58 11254472-7 2001 It involves both the MR and/or the glucocorticoid receptor (GR), depending on the retinoic or catecholamine induction pathway. Catecholamines 94-107 nuclear receptor subfamily 3, group C, member 1 Mus musculus 60-62 11373471-0 2001 Catecholamines play a role in the production of interleukin-6 and interleukin-1alpha in unburned skin after burn injury in mice. Catecholamines 0-14 interleukin 6 Mus musculus 48-61 11373471-0 2001 Catecholamines play a role in the production of interleukin-6 and interleukin-1alpha in unburned skin after burn injury in mice. Catecholamines 0-14 interleukin 1 alpha Mus musculus 66-84 11373471-1 2001 OBJECTIVE: To investigate the effects of catecholamines on the production of interleukin (IL)-6 and IL-1alpha in unburned skin after a burn injury. Catecholamines 41-55 interleukin 6 Mus musculus 77-95 11373471-1 2001 OBJECTIVE: To investigate the effects of catecholamines on the production of interleukin (IL)-6 and IL-1alpha in unburned skin after a burn injury. Catecholamines 41-55 interleukin 1 alpha Mus musculus 100-109 11310526-2 2001 Addition of vasopressin helped reduce standard catecholamine need while maintaining adequate arterial blood pressure. Catecholamines 47-60 arginine vasopressin Homo sapiens 12-23 11259096-3 2001 Serum chromogranin A was increased in 12 of 45 (27%) medullary thyroid carcinoma patients with an elevated calcitonin level and in 4 of 16 medullary thyroid carcinoma patients (25%) with an undetectable calcitonin level, in 5 of 7 phaeochromocytoma patients with increased urinary catecholamine and metabolite excretion, and in 2 of 3 patients with a non-functioning phaeochromocytoma. Catecholamines 281-294 chromogranin A Homo sapiens 6-20 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Catecholamines 226-240 GTP cyclohydrolase I feedback regulator Homo sapiens 0-48 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Catecholamines 226-240 GTP cyclohydrolase I feedback regulator Homo sapiens 50-54 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Catecholamines 226-240 GTP cyclohydrolase 1 Homo sapiens 0-20 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Catecholamines 226-240 phenylalanine hydroxylase Homo sapiens 281-306 11526963-0 2001 Abnormal presynaptic catecholamine regulation in a hyperactive SNAP-25-deficient mouse mutant. Catecholamines 21-34 synaptosomal-associated protein 25 Mus musculus 63-70 11241375-2 2001 Classically, C1 cells have been identified by their immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and/or phenylethanolamine N-methyltransferase (PNMT). Catecholamines 77-90 tyrosine hydroxylase Rattus norvegicus 112-132 11241375-2 2001 Classically, C1 cells have been identified by their immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and/or phenylethanolamine N-methyltransferase (PNMT). Catecholamines 77-90 tyrosine hydroxylase Rattus norvegicus 134-136 11465683-7 2001 An increase of catecholamines appears to increase glucose while both reducing insulin release and reducing sensitivity to insulin that is available. Catecholamines 15-29 insulin Homo sapiens 78-85 11245920-2 2001 In the present study, we tested the hypothesis that inhibition of catecholamine metabolism with the MAO-A inhibitor, clorgyline, might enhance cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens. Catecholamines 66-79 monoamine oxidase A Rattus norvegicus 100-105 11465683-7 2001 An increase of catecholamines appears to increase glucose while both reducing insulin release and reducing sensitivity to insulin that is available. Catecholamines 15-29 insulin Homo sapiens 122-129 11373409-1 2001 OBJECTIVE: To investigate the physiologic effects of exogenous vasopressin as a potential alternative to traditional high-dose catecholamine therapy for septic patients with vascular hyporeactivity to catecholamines. Catecholamines 201-215 arginine vasopressin Homo sapiens 63-74 11262584-0 2001 Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation. Catecholamines 0-13 carbonic anhydrase 1 Homo sapiens 55-75 11373409-4 2001 PATIENTS: Vasopressin was infused in 16 critically ill septic patients who remained persistently hypotensive despite infusions of pharmacologic doses of catecholamines. Catecholamines 153-167 arginine vasopressin Homo sapiens 10-21 11373409-13 2001 CONCLUSIONS: Low-dose vasopressin infusions increased mean arterial pressure, systemic vascular resistance, and urine output in patients with vasodilatory septic shock and hyporesponsiveness to catecholamines. Catecholamines 194-208 arginine vasopressin Homo sapiens 22-33 11495289-4 2001 In contrast to AChE inhibition, monoamine oxidase (MAO) activity showed an increasing trend and it could cause deamination of catecholamines and accumulation of its metabolites. Catecholamines 126-140 monoamine oxidase A Rattus norvegicus 32-49 11181495-7 2001 These forms also showed high activities toward umbelliferone and naringenin, but very low activities toward catecholamines, representative substrates of human ST1A5. Catecholamines 108-122 sulfotransferase family 1A member 3 Homo sapiens 159-164 11495289-4 2001 In contrast to AChE inhibition, monoamine oxidase (MAO) activity showed an increasing trend and it could cause deamination of catecholamines and accumulation of its metabolites. Catecholamines 126-140 monoamine oxidase A Rattus norvegicus 51-54 11325024-9 2001 These results suggest that cyclosporine increased blood pressure via activation of the catecholamine synthetic pathway due to the activation of transcription factor CREB. Catecholamines 87-100 cAMP responsive element binding protein 1 Rattus norvegicus 165-169 11207938-7 2001 This suggests that, in the guinea-pig, effects of opiates and catecholamines on LH release are exerted by independent pathways to luteinizing hormone releasing hormone (LHRH) neurones. Catecholamines 62-76 progonadoliberin-1 Cavia porcellus 130-167 11166521-8 2001 Thus, the balance of activation between 5-HT(2A) and 5-HT(2B/2C) receptors seems to contribute to the expression of locomotor hyperactivity evoked via combination of a 5-HT and a catecholamine reuptake inhibitor. Catecholamines 179-192 5-hydroxytryptamine receptor 2A Rattus norvegicus 40-47 11208582-0 2001 Role of PAC(1) receptor in adrenal catecholamine secretion induced by PACAP and VIP in vivo. Catecholamines 35-48 vasoactive intestinal peptide Canis lupus familiaris 80-83 11284440-15 2001 In conclusion, these data suggest a role for PAF in the pathogenesis of endotoxin-induced vascular and cardiac hyporesponsiveness to catecholamines and confirm its involvement in the complex cascade of multiple mediators released during endotoxic/septic shock. Catecholamines 133-147 PCNA clamp associated factor Rattus norvegicus 45-48 11164786-1 2001 Among the enzymes involved in the system for catecholamine biosynthesis, GTP cyclohydrolase I (GCH) contributes to the system as the first and rate-limiting enzyme for the de novo biosynthesis of tetrahydrobiopterin (BH4), which is the cofactor for tyrosine hydroxylase (TH). Catecholamines 45-58 GTP cyclohydrolase 1 Mus musculus 73-93 11164786-1 2001 Among the enzymes involved in the system for catecholamine biosynthesis, GTP cyclohydrolase I (GCH) contributes to the system as the first and rate-limiting enzyme for the de novo biosynthesis of tetrahydrobiopterin (BH4), which is the cofactor for tyrosine hydroxylase (TH). Catecholamines 45-58 GTP cyclohydrolase 1 Mus musculus 95-98 11236829-3 2001 With regard to the latter possibility, the absence of tyrosinase activity (encoded by Tyr) in albinos could alter tyrosine availability and thus the rate-limiting step in catecholamine synthesis. Catecholamines 171-184 tyrosinase Mus musculus 54-64 11164826-1 2001 3,4-Dihydroxyphenylglycolaldehyde is the monoamine oxidase-A metabolite of two catecholamine neurotransmitters, epinephrine and norepinephrine. Catecholamines 79-92 monoamine oxidase A Rattus norvegicus 41-60 11208582-1 2001 The present study was conducted to investigate the functional implication of the pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC(1)) receptor in the adrenal catecholamine (CA) secretion induced by either PACAP-27 or vasoactive intestinal polypeptide (VIP) in anesthetized dogs. Catecholamines 180-193 vasoactive intestinal peptide Canis lupus familiaris 239-272 11208582-1 2001 The present study was conducted to investigate the functional implication of the pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC(1)) receptor in the adrenal catecholamine (CA) secretion induced by either PACAP-27 or vasoactive intestinal polypeptide (VIP) in anesthetized dogs. Catecholamines 180-193 vasoactive intestinal peptide Canis lupus familiaris 274-277 11164858-9 2001 CONCLUSIONS: These results revealed, for the first time, that PAI-1 gene expression can be enhanced locally in the cardiovascular system by a fast-acting neurological mechanism triggered by glutamate receptors, whose pathway and relation to catecholamines, which exerted similar effects, have yet to be resolved. Catecholamines 241-255 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 62-67 11180299-1 2001 The determination of catecholamines and their 3-O-methyl metabolites in a single mouse plasma is necessary to understand the role of the sympathetic nervous activity, while the inactivation of catecholamines by catechol-O-methyltransferase indicates the activity of blood pressure regulation in animals. Catecholamines 193-207 catechol-O-methyltransferase Mus musculus 211-239 11207812-2 2001 Changes in dopamine release have been attributed to changes in the synthesis of dopamine, which is regulated via phosphorylation of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines. Catecholamines 204-218 tyrosine hydroxylase Rattus norvegicus 132-152 11292249-6 2001 The stimulation of APR activates the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the suppression of specific immunity, which might serve to protect the organism from adverse immune reactions; the immunostimulatory hormones (e.g., PRL, GH, IGF-1) are suppressed, whereas the production of APPs in the liver is stimulated by IL-6, catecholamines and GCs. Catecholamines 341-355 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 19-22 11207812-2 2001 Changes in dopamine release have been attributed to changes in the synthesis of dopamine, which is regulated via phosphorylation of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines. Catecholamines 204-218 tyrosine hydroxylase Rattus norvegicus 154-156 11244300-0 2001 Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1beta-induced hypothalamic pituitary adrenal axis responses. Catecholamines 29-42 interleukin 1 beta Mus musculus 93-110 11181834-10 2001 These results suggest that CRP40 could play a protective role against the harmful effects of catecholamine metabolites. Catecholamines 93-106 heat shock protein family A (Hsp70) member 9 Homo sapiens 27-32 11244300-2 2001 However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses to IL-1beta, the contributions of distinct brainstem catecholamine cell groups are not known. Catecholamines 40-53 corticotropin releasing hormone Mus musculus 94-97 11244300-2 2001 However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses to IL-1beta, the contributions of distinct brainstem catecholamine cell groups are not known. Catecholamines 40-53 interleukin 1 beta Mus musculus 116-124 11244300-3 2001 We examined the role of nucleus tractus solitarius (NTS) and ventrolateral medulla (VLM) catecholamine cells in the activation of mPVN CRH, hypothalamic oxytocin (OT) and central amygdala cells in response to IL-1beta (1 microg/kg, i.a.). Catecholamines 89-102 corticotropin releasing hormone Mus musculus 135-138 11244300-10 2001 These studies provide novel evidence that both the NTS and VLM catecholamine cells have important, but differential, contributions to the generation of IL-1beta-induced HPA axis responses. Catecholamines 63-76 interleukin 1 beta Mus musculus 152-160 11139479-4 2001 Transgenic mice expressing physiological levels of MKP-1 in the heart showed (1) no activation of p38, JNK1/2, or ERK1/2; (2) diminished developmental myocardial growth; and (3) attenuated hypertrophy in response to aortic banding and catecholamine infusion. Catecholamines 235-248 dual specificity phosphatase 1 Mus musculus 51-56 11141309-1 2001 Norepinephrine is N-methylated to epinephrine by the catalytic effect of the terminal enzyme in catecholamine biosynthesis, phenylethanolamine N-methyltransferase (PNMT). Catecholamines 96-109 phenylethanolamine N-methyltransferase Homo sapiens 124-162 11208687-13 2001 CONCLUSIONS: -Our data suggest that salt-depleted salt-sensitive hypertensives with blunted renin responses exhibit enhanced catecholamine-stimulated endothelin levels and may therefore respond better than unselected patients with essential hypertension to endothelin receptor blockers. Catecholamines 125-138 renin Homo sapiens 92-97 11141309-1 2001 Norepinephrine is N-methylated to epinephrine by the catalytic effect of the terminal enzyme in catecholamine biosynthesis, phenylethanolamine N-methyltransferase (PNMT). Catecholamines 96-109 phenylethanolamine N-methyltransferase Homo sapiens 164-168 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 tyrosine hydroxylase Rattus norvegicus 60-80 11407762-4 2001 In contrast, ADM stimulates medullary chromaffin cells to release catecholamines, which in turn enhance aldosterone secretion acting in a paracrine manner. Catecholamines 66-80 adrenomedullin Rattus norvegicus 13-16 11167155-4 2001 The aim of the present study was to investigate, if PCB-induced effects on concentrations of catecholamines and serotonin can be attributed to PCB-induced reductions in thyroid hormone concentrations. Catecholamines 93-107 pyruvate carboxylase Rattus norvegicus 52-55 11167155-4 2001 The aim of the present study was to investigate, if PCB-induced effects on concentrations of catecholamines and serotonin can be attributed to PCB-induced reductions in thyroid hormone concentrations. Catecholamines 93-107 pyruvate carboxylase Rattus norvegicus 143-146 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 tyrosine hydroxylase Rattus norvegicus 82-84 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 dopa decarboxylase Rattus norvegicus 87-122 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 dopa decarboxylase Rattus norvegicus 124-128 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 dopamine beta-hydroxylase Rattus norvegicus 134-159 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 dopamine beta-hydroxylase Rattus norvegicus 161-164 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 phenylethanolamine-N-methyltransferase Rattus norvegicus 209-247 11173223-2 2001 Immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), aromatic-L-amino-acid decarboxylase (AADC) and dopamine beta-hydroxylase (DBH) was present in all chromaffin cells, while phenylethanolamine N-methyltransferase (PNMT) was used to determine adrenergic chromaffin cell groups. Catecholamines 25-38 phenylethanolamine-N-methyltransferase Rattus norvegicus 249-253 11847483-1 2001 BACKGROUND: Interleukin-6 (IL-6) secretion is suppressed by glucocorticoids and stimulated by catecholamines. Catecholamines 94-108 interleukin 6 Homo sapiens 12-25 11139780-1 2001 Endothelins (ETs) mediate paracrine control of vascular tone and secretion of steroids and catecholamines in the adrenal gland through two ET receptor subtypes, ETA and ETB. Catecholamines 91-105 endothelin 1 Rattus norvegicus 0-11 11139780-1 2001 Endothelins (ETs) mediate paracrine control of vascular tone and secretion of steroids and catecholamines in the adrenal gland through two ET receptor subtypes, ETA and ETB. Catecholamines 91-105 endothelin receptor type A Rattus norvegicus 161-164 11139780-1 2001 Endothelins (ETs) mediate paracrine control of vascular tone and secretion of steroids and catecholamines in the adrenal gland through two ET receptor subtypes, ETA and ETB. Catecholamines 91-105 endothelin receptor type B Rattus norvegicus 169-172 11847483-1 2001 BACKGROUND: Interleukin-6 (IL-6) secretion is suppressed by glucocorticoids and stimulated by catecholamines. Catecholamines 94-108 interleukin 6 Homo sapiens 27-31 11516835-2 2001 In the case of physical stressors, there is considerable evidence that medullary catecholamine neurones are critical to the activation of the paraventricular nucleus corticotropin-releasing factor cells that constitute the apex of the hypothalamic-pituitary-adrenal axis. Catecholamines 81-94 corticotropin releasing hormone Homo sapiens 166-196 11274793-0 2001 Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain. Catecholamines 52-65 prostaglandin E receptor 3 Rattus norvegicus 14-17 10988298-2 2000 A large variety of proenkephalin-A-derived peptides (PEAPs) are present in bovine adrenal medulla secretory granules that are cosecreted with catecholamines upon stimulation of chromaffin cells. Catecholamines 142-156 proenkephalin Bos taurus 19-34 11118487-1 2000 We have investigated adrenal mRNA expression of the catecholamine synthetic enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) following acute hypoxia in fetal sheep before (< 105 days gestation, n = 20) and after (> 125 days gestation, n = 20) the development of adrenal innervation and following pretreatment with the nicotinic receptor anatgonist hexamethonium (n = 12). Catecholamines 52-65 phenylethanolamine N-methyltransferase Ovis aries 154-158 11100982-2 2000 We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. Catecholamines 140-153 natriuretic peptide A Rattus norvegicus 32-57 11100982-2 2000 We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. Catecholamines 140-153 natriuretic peptide A Rattus norvegicus 98-101 11100982-2 2000 We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. Catecholamines 140-153 natriuretic peptide B Rattus norvegicus 103-106 11100982-2 2000 We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. Catecholamines 140-153 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 112-115 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 0-28 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 30-34 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 129-133 11368324-1 2000 Catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines, is present in mammals as soluble (S-COMT) and membrane-bound (MB-COMT) forms. Catecholamines 77-91 catechol-O-methyltransferase Rattus norvegicus 129-133 11090979-5 2000 This report supports the notion that PACAP is an activator and modulator of catecholamine secretion as well as synthesis in the adrenal medulla. Catecholamines 76-89 adenylate cyclase activating polypeptide 1 Rattus norvegicus 37-42 11191644-6 2000 In NALM-6 cells, both alpha-methyl-p-tyrosine and the dopamine-beta-hydroxylase inhibitor disulfiram reduced intracellular CTs, supporting the presence of active synthetic pathways in these cells. Catecholamines 123-126 dopamine beta-hydroxylase Homo sapiens 54-79 11102496-1 2000 The A1 catecholamine neurons of the caudal ventrolateral medulla transmit hemodynamic information to the vasopressin (VP) neurons in the hypothalamus. Catecholamines 7-20 arginine vasopressin Homo sapiens 105-116 11118030-6 2000 We demonstrate defects in insulin action on 2-deoxy-D-glucose transport (SHRSP 3.3 +/- 1.5 vs. 21.0 +/- 7.4 pmol x min(-1) x [20 microl packed cells](-1), SHRSP vs. WKY, respectively, P = 0.01) and inhibition of catecholamine-stimulated lipolysis (P < 0.05 at all concentrations of insulin) in adipocytes isolated from SHRSP. Catecholamines 212-225 insulin Homo sapiens 26-33 11110887-5 2000 Fasting leads to a gradual decline in serum leptin that is probably attributable to the decline in insulin and the ability of catecholamines to decrease leptin expression, as observed in both in vivo and in vitro studies. Catecholamines 126-140 leptin Homo sapiens 44-50 11102496-1 2000 The A1 catecholamine neurons of the caudal ventrolateral medulla transmit hemodynamic information to the vasopressin (VP) neurons in the hypothalamus. Catecholamines 7-20 arginine vasopressin Homo sapiens 118-120 11110887-5 2000 Fasting leads to a gradual decline in serum leptin that is probably attributable to the decline in insulin and the ability of catecholamines to decrease leptin expression, as observed in both in vivo and in vitro studies. Catecholamines 126-140 leptin Homo sapiens 153-159 11121511-11 2000 Through this mechanism, systemically, endogenous catecholamines may cause a selective suppression of Th1 responses and cellular immunity, and a Th2 shift toward dominance of humoral immunity. Catecholamines 49-63 negative elongation factor complex member C/D Homo sapiens 101-104 11093795-0 2000 Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP-dependent extracellular signal-regulated kinase activation. Catecholamines 4-17 Eph receptor B1 Rattus norvegicus 113-150 11121511-12 2000 On the other hand, in certain local responses, and under certain conditions, catecholamines may actually boost regional immune responses, through induction of IL-1, tumor necrosis factor-alpha, and primarily IL-8 production. Catecholamines 77-91 interleukin 1 alpha Homo sapiens 159-192 11121511-12 2000 On the other hand, in certain local responses, and under certain conditions, catecholamines may actually boost regional immune responses, through induction of IL-1, tumor necrosis factor-alpha, and primarily IL-8 production. Catecholamines 77-91 C-X-C motif chemokine ligand 8 Homo sapiens 208-212 10940302-2 2000 The counterregulatory actions of insulin on catecholamine action are well known and include phosphorylation of the beta(2)-adrenergic receptor on Tyr(350), Tyr(354), and Tyr(364) in the C-terminal cytoplasmic domain, as well as enhanced sequestration of the beta(2)-adrenergic receptor. Catecholamines 44-57 insulin Homo sapiens 33-40 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 interleukin 6 Homo sapiens 102-115 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 interleukin 6 Homo sapiens 117-121 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 tumor necrosis factor Homo sapiens 127-154 11084220-1 2000 There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). Catecholamines 28-42 tumor necrosis factor Homo sapiens 156-165 11062327-0 2000 Interaction of the catecholamine release-inhibitory peptide catestatin (human chromogranin A(352-372)) with the chromaffin cell surface and Torpedo electroplax: implications for nicotinic cholinergic antagonism. Catecholamines 19-32 chromogranin A Homo sapiens 60-70 11062327-0 2000 Interaction of the catecholamine release-inhibitory peptide catestatin (human chromogranin A(352-372)) with the chromaffin cell surface and Torpedo electroplax: implications for nicotinic cholinergic antagonism. Catecholamines 19-32 chromogranin A Homo sapiens 78-92 11062327-1 2000 The catecholamine release-inhibitory chromogranin A fragment catestatin (chromogranin A(344-364)) exhibits non-competitive antagonism of nicotinic cholinergic signaling in chromaffin cells. Catecholamines 4-17 chromogranin A Homo sapiens 37-51 11062327-1 2000 The catecholamine release-inhibitory chromogranin A fragment catestatin (chromogranin A(344-364)) exhibits non-competitive antagonism of nicotinic cholinergic signaling in chromaffin cells. Catecholamines 4-17 chromogranin A Homo sapiens 61-71 11062327-1 2000 The catecholamine release-inhibitory chromogranin A fragment catestatin (chromogranin A(344-364)) exhibits non-competitive antagonism of nicotinic cholinergic signaling in chromaffin cells. Catecholamines 4-17 chromogranin A Homo sapiens 73-87 10940302-2 2000 The counterregulatory actions of insulin on catecholamine action are well known and include phosphorylation of the beta(2)-adrenergic receptor on Tyr(350), Tyr(354), and Tyr(364) in the C-terminal cytoplasmic domain, as well as enhanced sequestration of the beta(2)-adrenergic receptor. Catecholamines 44-57 adrenoceptor beta 2 Homo sapiens 115-142 10940302-2 2000 The counterregulatory actions of insulin on catecholamine action are well known and include phosphorylation of the beta(2)-adrenergic receptor on Tyr(350), Tyr(354), and Tyr(364) in the C-terminal cytoplasmic domain, as well as enhanced sequestration of the beta(2)-adrenergic receptor. Catecholamines 44-57 adrenoceptor beta 2 Homo sapiens 258-285 11195784-8 2000 Varying degrees of defects in the beta-AR signal transduction system have been identified in different types of heart failure to explain the attenuated response of the failing heart to sympathetic stimulation or catecholamine infusion. Catecholamines 212-225 adrenergic receptor, beta 1 Mus musculus 34-41 11078453-11 2000 Double-label immunohistochemistry showed that Fos-ir was reduced or abolished in catecholamine cell groups A1, A1/C1, C1, C3, and A6 and in the paraventricular nucleus of the hypothalamus and adrenal medulla. Catecholamines 81-94 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 46-49 11078453-11 2000 Double-label immunohistochemistry showed that Fos-ir was reduced or abolished in catecholamine cell groups A1, A1/C1, C1, C3, and A6 and in the paraventricular nucleus of the hypothalamus and adrenal medulla. Catecholamines 81-94 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 111-132 11246817-1 2000 Recent studies showed that catecholamines contribute to the regulation of plasminogen activator inhibitor-1 (PAI-1) expression, at least in endothelial cells. Catecholamines 27-41 serpin family E member 1 Homo sapiens 74-107 11246817-1 2000 Recent studies showed that catecholamines contribute to the regulation of plasminogen activator inhibitor-1 (PAI-1) expression, at least in endothelial cells. Catecholamines 27-41 serpin family E member 1 Homo sapiens 109-114 11246817-2 2000 Aim of this study was to examine the role of catecholamines on PAI-1 production by human adipocytes and, in particular, to clarify which adrenoceptor (AR) subtypes are involved. Catecholamines 45-59 serpin family E member 1 Homo sapiens 63-68 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 153-166 tyrosine hydroxylase Rattus norvegicus 188-208 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 153-166 tyrosine hydroxylase Rattus norvegicus 210-212 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 153-166 dopamine beta-hydroxylase Rattus norvegicus 218-243 11032889-1 2000 Nicotine treatment increases intracellular free Ca(2+) concentration [Ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 153-166 dopamine beta-hydroxylase Rattus norvegicus 245-248 11076506-1 2000 Tetrahydropterins are obligatory cofactors for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 102-115 tyrosine hydroxylase Homo sapiens 47-67 11076506-1 2000 Tetrahydropterins are obligatory cofactors for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 102-115 tyrosine hydroxylase Homo sapiens 69-71 11246817-7 2000 In conclusion, the results of this study support the assumption that catecholamines are able to down-regulate PAI-1 expression and secretion in human adipocytes via beta-adrenergic receptors. Catecholamines 69-83 serpin family E member 1 Homo sapiens 110-115 11121573-1 2000 beta-Adrenoceptors of the beta1 and beta2 subtypes classically mediate the effects of catecholamines on the contractility of cardiac muscle and the relaxation of vascular smooth muscle. Catecholamines 86-100 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 26-31 11121573-1 2000 beta-Adrenoceptors of the beta1 and beta2 subtypes classically mediate the effects of catecholamines on the contractility of cardiac muscle and the relaxation of vascular smooth muscle. Catecholamines 86-100 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 36-41 11121573-5 2000 These data might provide new insights into our understanding of the abnormal responsiveness of the cardiovascular system to catecholamines in heart failure and its treatment with beta3-adrenoceptor antagonists. Catecholamines 124-138 adrenoceptor beta 3 Homo sapiens 179-197 10982471-1 2000 The noradrenergic innervation of the mouse cerebellum, which is known for its important modulatory function, was analyzed immunocytochemically with an antibody against tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 218-231 tyrosine hydroxylase Mus musculus 168-188 12847574-1 2000 This review describes the pharmacological aspects of renin release with special emphasis on the role of sympathetic nervous system, catecholamines, adrenoceptor blocking drugs, humoral agents, adrenalectomy and chemical sympathectomy. Catecholamines 132-146 renin Homo sapiens 53-58 11018298-1 2000 Factors regulating tyrosine hydroxylase (TH) gene transcription are of major importance in the studies of malignant and degenerative diseases of catecholamine-synthesizing tissues. Catecholamines 145-158 tyrosine hydroxylase Homo sapiens 19-39 11018298-1 2000 Factors regulating tyrosine hydroxylase (TH) gene transcription are of major importance in the studies of malignant and degenerative diseases of catecholamine-synthesizing tissues. Catecholamines 145-158 tyrosine hydroxylase Homo sapiens 41-43 11011035-0 2000 Role of endogenous endothelins in catecholamine secretion in the rat adrenal gland. Catecholamines 34-47 endothelin 1 Rattus norvegicus 19-30 11011035-1 2000 We investigated the role of endogenous endothelins in catecholamine secretion in response to transmural electrical stimulation in the retrogradely perfused rat adrenal gland. Catecholamines 54-67 endothelin 1 Rattus norvegicus 39-50 11033330-13 2000 Both CRF and vasopressin have effects in the same direction on behavior, learning and memory processes and stress responses (release of catecholamines and ACTH). Catecholamines 136-150 arginine vasopressin Rattus norvegicus 13-24 10998441-1 2000 Pheochromocytoma and its extra-adrenal counterpart paraganglioma are rare catecholamine producing tumors which usually occur sporadically but may also be a part of neuroendocrine tumor syndromes such as multiple endocrine neoplasia type 2A (MEN 2A). Catecholamines 74-87 ret proto-oncogene Homo sapiens 203-239 11018079-0 2000 Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. Catecholamines 82-95 chromogranin A Rattus norvegicus 14-28 11018079-1 2000 Chromogranin A (CgA) is the major soluble protein in the core of catecholamine-storage vesicles and is also distributed widely in secretory vesicles throughout the neuroendocrine system. Catecholamines 65-78 chromogranin A Rattus norvegicus 0-14 11018079-1 2000 Chromogranin A (CgA) is the major soluble protein in the core of catecholamine-storage vesicles and is also distributed widely in secretory vesicles throughout the neuroendocrine system. Catecholamines 65-78 chromogranin A Rattus norvegicus 16-19 11018079-2 2000 CgA contains the sequences for peptides that modulate catecholamine release, but the proteases responsible for the release of these bioactive peptides from CgA have not been established. Catecholamines 54-67 chromogranin A Rattus norvegicus 0-3 11018079-4 2000 Peptides generated by plasmin-mediated cleavage of CgA significantly inhibited nicotinic cholinergic stimulation of catecholamine release from PC12 cells and primary bovine adrenal chromaffin cells. Catecholamines 116-129 chromogranin A Rattus norvegicus 51-54 11018079-9 2000 Interactions between CgA and plasmin(ogen) define a previously unrecognized autocrine/paracrine system that may have a dramatic impact upon catecholamine secretion. Catecholamines 140-153 chromogranin A Rattus norvegicus 21-24 11007894-4 2000 Although both lines lack TH, their catecholamine levels differ because tyrosinase in pigmented mice serves as an alternative source for catecholamine synthesis (Rios et al., 1999). Catecholamines 35-48 tyrosinase Mus musculus 71-81 11007894-4 2000 Although both lines lack TH, their catecholamine levels differ because tyrosinase in pigmented mice serves as an alternative source for catecholamine synthesis (Rios et al., 1999). Catecholamines 136-149 tyrosinase Mus musculus 71-81 11007894-7 2000 Treatment of albino TH null mice with DOPA, a catecholamine precursor, from P11 to P21 increases the number of active glands to 14. Catecholamines 46-59 S100 calcium binding protein A10 (calpactin) Mus musculus 76-79 11007894-8 2000 Pigmented TH null mice, which have faint catecholamine fluorescence in the developing gland innervation, possess 12 active glands at P21, indicating that catecholamines made via tyrosinase, albeit reduced from wild-type levels, support development of responsiveness. Catecholamines 154-168 tyrosinase Mus musculus 178-188 10986341-8 2000 We conclude that at 85% of gestation the potential for VIP neural control of paracrine (e.g., glucocorticoid/catecholamine) interactions in both adrenal cortex and medulla is much greater in fetal sheep compared to fetal baboons. Catecholamines 109-122 vasoactive intestinal peptide Ovis aries 55-58 11501170-1 2000 AIM: To study the influence of angiotensin (Ang) II receptor antagonist (AT1) valsartan and angiotensin-converting enzyme (ACE) inhibitor fosinopril on the cardiac hypertrophy induced by catecholamine. Catecholamines 187-200 angiotensin I converting enzyme Homo sapiens 92-121 10986333-7 2000 NGFI-A, NGFI-B and Nurr1 expression persisted for 6 h. Since the IEGs studied had major differences in their temporospatial induction pattern, they are likely to be induced by distinct stress-elicited factors and have separate target genes and roles in stress-induced glucocorticoid and catecholamine secretion. Catecholamines 287-300 nuclear receptor subfamily 4, group A, member 2 Rattus norvegicus 19-24 11045604-5 2000 Systemic administration to chickens of alpha-methyl-p-tyrosine (an inhibitor of catecholamine synthesis; 0.3 g/kg) blocked the suppressive effect of UV-A light on retinal AA-NAT activity. Catecholamines 80-93 aralkylamine N-acetyltransferase Gallus gallus 171-177 10984661-3 2000 The present gas chromatographic-mass spectrometric analysis of the phenylalanine and catecholamine metabolisms demonstrated the former metabolism to remain disturbed even in adult hph-1, which demonstrated a metabolic basis for sensitivity to the phenylalanine challenge in adult hph-1. Catecholamines 85-98 hyperphenylalaninemia 1 Mus musculus 180-185 10942707-9 2000 Mobilization of CD14(+)CD16(+) monocytes by a catecholamine-dependent mechanism may contribute to the increase of these cells in various clinical conditions. Catecholamines 46-59 CD14 molecule Homo sapiens 16-20 10942707-9 2000 Mobilization of CD14(+)CD16(+) monocytes by a catecholamine-dependent mechanism may contribute to the increase of these cells in various clinical conditions. Catecholamines 46-59 Fc gamma receptor IIIa Homo sapiens 23-27 11022189-0 2000 Catecholamines suppress leptin release from in vitro differentiated subcutaneous human adipocytes in primary culture via beta1- and beta2-adrenergic receptors. Catecholamines 0-14 leptin Homo sapiens 24-30 11022189-1 2000 OBJECTIVE: Circulating leptin, the product of the ob gene, is known to be closely correlated with adipose tissue mass, but it is also subject to short-term regulation by a variety of hormones including catecholamines. Catecholamines 202-216 leptin Homo sapiens 23-29 11022189-13 2000 These data provide evidence that catecholamines are able to suppress leptin release from differentiated human adipocytes, supporting the concept that leptin secretion is acutely regulated by surrounding hormones. Catecholamines 33-47 leptin Homo sapiens 69-75 11144961-2 2000 Indicative of the adrenal chromaffin phenotype, these cells expressed immunoreactivity (ir) for tyrosine hydroxylase (TH), the first enzyme in the synthetic pathway for catecholamines. Catecholamines 169-183 tyrosine hydroxylase Rattus norvegicus 96-116 11144961-2 2000 Indicative of the adrenal chromaffin phenotype, these cells expressed immunoreactivity (ir) for tyrosine hydroxylase (TH), the first enzyme in the synthetic pathway for catecholamines. Catecholamines 169-183 tyrosine hydroxylase Rattus norvegicus 118-120 11144961-8 2000 These grafted chromaffin cells also expressed immunoreactivities for the other catecholamine-synthesizing enzymes 7 weeks after grafting, including: dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 79-92 dopamine beta-hydroxylase Rattus norvegicus 149-174 11144961-8 2000 These grafted chromaffin cells also expressed immunoreactivities for the other catecholamine-synthesizing enzymes 7 weeks after grafting, including: dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 79-92 phenylethanolamine-N-methyltransferase Rattus norvegicus 188-226 11144961-8 2000 These grafted chromaffin cells also expressed immunoreactivities for the other catecholamine-synthesizing enzymes 7 weeks after grafting, including: dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 79-92 phenylethanolamine-N-methyltransferase Rattus norvegicus 228-232 11022189-13 2000 These data provide evidence that catecholamines are able to suppress leptin release from differentiated human adipocytes, supporting the concept that leptin secretion is acutely regulated by surrounding hormones. Catecholamines 33-47 leptin Homo sapiens 150-156 10984661-3 2000 The present gas chromatographic-mass spectrometric analysis of the phenylalanine and catecholamine metabolisms demonstrated the former metabolism to remain disturbed even in adult hph-1, which demonstrated a metabolic basis for sensitivity to the phenylalanine challenge in adult hph-1. Catecholamines 85-98 hyperphenylalaninemia 1 Mus musculus 280-285 10984662-3 2000 In this paper, we describe the mice lacking expression of tyrosine hydroxylase (TH), the first and rate-limiting enzyme of catecholamine biosynthetic pathway, in the dopaminergic neuronal type. Catecholamines 123-136 tyrosine hydroxylase Mus musculus 58-78 10984662-3 2000 In this paper, we describe the mice lacking expression of tyrosine hydroxylase (TH), the first and rate-limiting enzyme of catecholamine biosynthetic pathway, in the dopaminergic neuronal type. Catecholamines 123-136 tyrosine hydroxylase Mus musculus 80-82 11108135-0 2000 Catecholamines induce IL-10 release in patients suffering from acute myocardial infarction by transactivating its promoter in monocytic but not in T-cells. Catecholamines 0-14 interleukin 10 Homo sapiens 22-27 10945842-0 2000 Aryloxypropanolamine and catecholamine ligand interactions with the beta(1)-adrenergic receptor: evidence for interaction with distinct conformations of beta(1)-adrenergic receptors. Catecholamines 25-38 adrenoceptor beta 1 Homo sapiens 68-95 10945842-6 2000 Activation of beta(1)-AR by CGP 12177 or LY 362884 was observed to be significantly more resistant to blockade by beta-AR antagonists compared with activation by catecholamines. Catecholamines 162-176 adrenoceptor beta 1 Homo sapiens 14-24 10945842-7 2000 These results suggest that catecholamines and aryloxypropanolamines interact with distinct active conformations of the beta(1)-AR: a state that is responsive to catecholamines and is blocked with high affinity by CGP 12177 and LY 362884, and a novel state that is activated by aryloxypropanolamines but is resistant to blockade by standard beta-AR antagonists. Catecholamines 27-41 adrenoceptor beta 1 Homo sapiens 119-129 10945842-7 2000 These results suggest that catecholamines and aryloxypropanolamines interact with distinct active conformations of the beta(1)-AR: a state that is responsive to catecholamines and is blocked with high affinity by CGP 12177 and LY 362884, and a novel state that is activated by aryloxypropanolamines but is resistant to blockade by standard beta-AR antagonists. Catecholamines 161-175 adrenoceptor beta 1 Homo sapiens 119-129 10974664-5 2000 Thus, this is the first study to demonstrate a direct stimulatory role for VIP or PACAP in catecholamine secretion from piscine chromaffin cells. Catecholamines 91-104 vasoactive intestinal peptide Gallus gallus 75-78 10971810-5 2000 We investigated in parallel another enzyme: tyrosine hydroxylase, the rate limiting step in catecholamine synthesis. Catecholamines 92-105 tyrosine 3-monooxygenase Coturnix japonica 44-64 11039590-1 2000 Chromogranin A (CGA) is a member of a family of highly acidic proteins co-stored and co-released with catecholamines in the adrenal medullary cells as well as in other neurons and paraneurons. Catecholamines 102-116 chromogranin A Equus caballus 0-14 11039590-1 2000 Chromogranin A (CGA) is a member of a family of highly acidic proteins co-stored and co-released with catecholamines in the adrenal medullary cells as well as in other neurons and paraneurons. Catecholamines 102-116 chromogranin A Equus caballus 16-19 11108136-1 2000 The conversion of L-tyrosine to 3,4-dihydroxy-L-phenylalanine by tyrosine hydroxylase (TH) is the first and rate-limiting step in biosynthesis of catecholamine neurotransmitters. Catecholamines 146-159 tyrosine hydroxylase Homo sapiens 65-85 11108136-1 2000 The conversion of L-tyrosine to 3,4-dihydroxy-L-phenylalanine by tyrosine hydroxylase (TH) is the first and rate-limiting step in biosynthesis of catecholamine neurotransmitters. Catecholamines 146-159 tyrosine hydroxylase Homo sapiens 87-89 11108135-3 2000 In vitro and in vivo studies in experimental models suggest that catecholamines induce IL-10 release via a cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) dependent pathway. Catecholamines 65-79 interleukin 10 Homo sapiens 87-92 11108135-6 2000 Catecholamine induced IL-10 may be released by different cells. Catecholamines 0-13 interleukin 10 Homo sapiens 22-27 11108135-7 2000 Recently, we demonstrated that catecholamines directly stimulate the IL-10 promoter/enhancer via a cAMP/PKA pathway in monocytic cells. Catecholamines 31-45 interleukin 10 Homo sapiens 69-74 11108135-11 2000 Thus, catecholamines are directly involved in the regulation of IL-10 expression in monocytic but not in T-cells after acute stressful conditions. Catecholamines 6-20 interleukin 10 Homo sapiens 64-69 10906719-0 2000 Calbindin-immunoreactive neurons in the reticular formation of the rat brainstem: catecholamine content and spinal projections. Catecholamines 82-95 calbindin 1 Rattus norvegicus 0-9 10913336-5 2000 Orexin-A and -B (100 nM) significantly reduced basal and PACAP-induced tyrosine hydroxylase (TH) (the rate-limiting enzyme in the biosynthesis of catecholamines) mRNA levels. Catecholamines 146-160 hypocretin neuropeptide precursor Rattus norvegicus 0-15 10944175-16 2000 The results indicate that amylin (like catecholamines, cAMP, CGRP and insulin) stimulates the Na+-K+ pump and thereby improves the contractility of depolarized skeletal muscle cells. Catecholamines 39-53 islet amyloid polypeptide Rattus norvegicus 26-32 10924322-1 2000 Expression of the gene encoding tyrosine hydroxylase (TH), the initial and rate-limiting enzyme of catecholamine biosynthesis, is regulated at the transcriptional level during neuronal development and in response to a variety of environmental stimuli. Catecholamines 99-112 tyrosine hydroxylase Rattus norvegicus 32-52 10924322-1 2000 Expression of the gene encoding tyrosine hydroxylase (TH), the initial and rate-limiting enzyme of catecholamine biosynthesis, is regulated at the transcriptional level during neuronal development and in response to a variety of environmental stimuli. Catecholamines 99-112 tyrosine hydroxylase Rattus norvegicus 54-56 10913336-5 2000 Orexin-A and -B (100 nM) significantly reduced basal and PACAP-induced tyrosine hydroxylase (TH) (the rate-limiting enzyme in the biosynthesis of catecholamines) mRNA levels. Catecholamines 146-160 marginal zone B and B1 cell-specific protein Rattus norvegicus 57-62 11028916-10 2000 Since PHM is homologous in sequence and mechanism to dopamine beta-monooxygenase (DBM; EC 1.14.17.1), the enzyme that converts dopamine to norepinephrine during catecholamine biosynthesis, these structural and mechanistic insights are extended to DBM. Catecholamines 161-174 dopamine beta-hydroxylase Rattus norvegicus 53-80 10938240-6 2000 Furthermore, immunohistochemical analysis showed that ET-1 and tyrosine hydroxylase, an enzyme in the catecholamine synthesis pathway, were colocalized within certain neurons of the hypothalamus and amygdala. Catecholamines 102-115 endothelin 1 Mus musculus 54-83 10938240-7 2000 Our findings suggest that ET-1 modulates central coordination of stress responses in close association with catecholamine metabolism. Catecholamines 108-121 endothelin 1 Mus musculus 26-30 11177225-4 2000 The lowest content of serum ceruloplasmin is observed in the most grave early neurological form of Wilson"s disease (according to N. V. Konovalov"s classification), which confirms the important role of ceruloplasmin in the striatal metabolism of catecholamines. Catecholamines 246-260 ceruloplasmin Homo sapiens 28-41 10896916-1 2000 BACKGROUND AND AIMS: Previous studies on rodents have suggested that catecholamines stimulate proliferation of the intestinal epithelium through activation of alpha(2) adrenoceptors located on crypt cells. Catecholamines 69-83 adrenoceptor alpha 2A Homo sapiens 159-181 10985689-0 2000 Caudal brainstem Fos expression is restricted to periventricular catecholamine neuron-containing loci following intraventricular administration of 2-deoxy-D-glucose. Catecholamines 65-78 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 17-20 11103895-2 2000 It has been reported to be a non-competitive blocker of nicotinic receptors, with a potent inhibitory action on nicotinic acetylcholine receptor-mediated catecholamine release. Catecholamines 154-167 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 112-144 10915581-8 2000 Tyrosine hydroxylase immunoreactivity indicated prolonged transplant survival and production of catecholamines. Catecholamines 96-110 tyrosine hydroxylase Homo sapiens 0-20 10929091-7 2000 Therefore, to obtain some indication of oestrogen"s possible site(s) of action, Fos-like immunolabelling was mapped in the amygdala and in brainstem catecholamine groups, which are neuronal populations demonstrating substantial evidence of involvement in the generation of HPA axis stress responses. Catecholamines 149-162 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 80-83 10899948-1 2000 Aromatic L-amino acid decarboxylase (AAAD), an enzyme required for the synthesis of catecholamines, indoleamines, and trace amines, is rapidly activated by cyclic AMP-dependent pathways in striatum and midbrain in vivo, suggesting enzyme phosphorylation. Catecholamines 84-98 dopa decarboxylase Mus musculus 0-35 10899948-1 2000 Aromatic L-amino acid decarboxylase (AAAD), an enzyme required for the synthesis of catecholamines, indoleamines, and trace amines, is rapidly activated by cyclic AMP-dependent pathways in striatum and midbrain in vivo, suggesting enzyme phosphorylation. Catecholamines 84-98 dopa decarboxylase Mus musculus 37-41 10908602-8 2000 These studies emphasize the potential importance of stress-evoked increases in the expression of the Fra2 gene for in vivo adaptations of the adrenal catecholamine producing system. Catecholamines 150-163 FOS like 2, AP-1 transcription factor subunit Rattus norvegicus 101-105 10908734-3 2000 U-69593 (a kappa-opioid agonist: >/=100 nM) significantly inhibited the nicotine-induced increase of tyrosine hydroxylase (TH, a rate-limiting enzyme in biosynthesis of catecholamine) enzyme activity and TH mRNA levels. Catecholamines 172-185 tyrosine hydroxylase Rattus norvegicus 104-124 10781584-0 2000 Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Catecholamines 17-30 chromogranin A Homo sapiens 58-68 10781584-0 2000 Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Catecholamines 17-30 chromogranin A Homo sapiens 74-88 10781584-2 2000 The catestatin fragment of chromogranin A is an inhibitor of catecholamine release, but its occurrence in vivo has not yet been verified, nor have its precise cleavage sites been established. Catecholamines 61-74 chromogranin A Homo sapiens 4-14 10781584-2 2000 The catestatin fragment of chromogranin A is an inhibitor of catecholamine release, but its occurrence in vivo has not yet been verified, nor have its precise cleavage sites been established. Catecholamines 61-74 chromogranin A Homo sapiens 27-41 10781584-6 2000 Synthetic longer (chromogranin A(332-364)) and shorter (chromogranin A(344-364)) versions of catestatin each inhibited catecholamine release from chromaffin cells, with superior potency for the shorter version (IC(50) approximately 2.01 versus approximately 0.35 microm). Catecholamines 119-132 chromogranin A Homo sapiens 93-103 10908734-3 2000 U-69593 (a kappa-opioid agonist: >/=100 nM) significantly inhibited the nicotine-induced increase of tyrosine hydroxylase (TH, a rate-limiting enzyme in biosynthesis of catecholamine) enzyme activity and TH mRNA levels. Catecholamines 172-185 tyrosine hydroxylase Rattus norvegicus 126-128 10912793-10 2000 Therefore, catecholamines acting via the (alpha1)AR may modulate these physiological and pathological processes. Catecholamines 11-25 adrenoceptor alpha 1D Homo sapiens 42-48 10933217-6 2000 Parallels are identified in human subjects receiving drugs such as the indirect catecholamine agonists L-dopa, methylphenidate and the dopamine D2 receptor blocker sulpiride. Catecholamines 80-93 dopamine receptor D2 Homo sapiens 135-155 10871314-1 2000 Natriuretic peptides suppress evoked catecholamine efflux by a mechanism attributed to activation of the natriuretic peptide receptor (NPR)-C, but this designation relies on the absolute specificity of truncated natriuretic peptide analogs for the NPR-C. Catecholamines 37-50 neuronal pentraxin receptor Homo sapiens 105-133 10860763-1 2000 Catecholamines modulate cardiac function at least in part through alpha(1)-adrenergic receptors linked to the activation of protein kinase C (PKC). Catecholamines 0-14 protein kinase C alpha Homo sapiens 142-145 10904050-2 2000 Intense exercise increases catecholamines, and catecholamines without exercise can affect the expression of both LPL and GLUT-4. Catecholamines 47-61 lipoprotein lipase Homo sapiens 113-116 10904050-2 2000 Intense exercise increases catecholamines, and catecholamines without exercise can affect the expression of both LPL and GLUT-4. Catecholamines 47-61 solute carrier family 2 member 4 Homo sapiens 121-127 10871314-1 2000 Natriuretic peptides suppress evoked catecholamine efflux by a mechanism attributed to activation of the natriuretic peptide receptor (NPR)-C, but this designation relies on the absolute specificity of truncated natriuretic peptide analogs for the NPR-C. Catecholamines 37-50 neuronal pentraxin receptor Homo sapiens 135-138 10871314-2 2000 The NPR-C involvement in evoked catecholamine efflux was defined better in this study by selectively ablating the NPR-C in pheochromocytoma cells with antisense oligodeoxynucleotides. Catecholamines 32-45 natriuretic peptide receptor 3 Homo sapiens 4-9 10871314-2 2000 The NPR-C involvement in evoked catecholamine efflux was defined better in this study by selectively ablating the NPR-C in pheochromocytoma cells with antisense oligodeoxynucleotides. Catecholamines 32-45 natriuretic peptide receptor 3 Homo sapiens 114-119 10871314-4 2000 The reduction of NPR-C levels suppressed evoked catecholamine efflux 33 +/- 6% and eliminated the effect of C-type natriuretic peptide to suppress evoked catecholamine efflux. Catecholamines 48-61 natriuretic peptide receptor 3 Homo sapiens 17-22 10871314-4 2000 The reduction of NPR-C levels suppressed evoked catecholamine efflux 33 +/- 6% and eliminated the effect of C-type natriuretic peptide to suppress evoked catecholamine efflux. Catecholamines 154-167 natriuretic peptide receptor 3 Homo sapiens 17-22 10871314-4 2000 The reduction of NPR-C levels suppressed evoked catecholamine efflux 33 +/- 6% and eliminated the effect of C-type natriuretic peptide to suppress evoked catecholamine efflux. Catecholamines 154-167 natriuretic peptide C Homo sapiens 108-134 10871314-5 2000 The native peptide, C-type natriuretic peptide, reduced evoked catecholamine efflux 39 +/- 3% in cells with a normal complement of NPR-C. Catecholamines 63-76 natriuretic peptide C Homo sapiens 20-46 10927191-1 2000 Catecholamines and serotonin, which act as neurotransmitters and regulate blood circulation, are degraded by monoamine oxidase (MAO) [EC 1.4.3.4.] Catecholamines 0-14 monoamine oxidase A Rattus norvegicus 109-126 10927191-1 2000 Catecholamines and serotonin, which act as neurotransmitters and regulate blood circulation, are degraded by monoamine oxidase (MAO) [EC 1.4.3.4.] Catecholamines 0-14 monoamine oxidase A Rattus norvegicus 128-131 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 11-39 10862823-3 2000 The elevation of both catecholamines induced by melittin (10 microg/animal) was abolished by centrally administered mepacrine (an inhibitor of phospholipase A(2)), but not by neomycin (an inhibitor of phospholipase C). Catecholamines 22-36 phospholipase A and acyltransferase 1 Rattus norvegicus 143-158 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Catecholamines 86-100 catechol-O-methyltransferase Homo sapiens 41-45 10833449-6 2000 Tyrosine hydroxylase (TH) is a rate-limiting enzyme in the biosynthesis of catecholamine, and its activity is regulated by both TH-enzyme activity and TH-synthesis. Catecholamines 75-88 tyrosine hydroxylase Homo sapiens 0-20 10888068-0 2000 Ethanol-induced c-fos expression in catecholamine- and neuropeptide Y-producing neurons in rat brainstem. Catecholamines 36-49 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 16-21 10888068-12 2000 CONCLUSIONS: Neurons in the rat brainstem that show ethanol-induced c-Fos expression produce catecholamines and NPY. Catecholamines 93-107 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 68-73 10942111-8 2000 Since EMT and OCT2 may play important roles in catecholamine homeostasis and, as such, are candidate genes in human disease, the present results provide a basis for the analysis of genetic variation and the regulation of transcription. Catecholamines 47-60 IL2 inducible T cell kinase Homo sapiens 6-9 10853217-0 2000 Vasopressin effective in reversing catecholamine-resistant vasodilatory shock. Catecholamines 35-48 arginine vasopressin Homo sapiens 0-11 10853217-4 2000 The experience with this case suggests that vasopressin may be a valuable adjunct to the treatment of catecholamine-resistant vasodilatory shock. Catecholamines 102-115 arginine vasopressin Homo sapiens 44-55 10915008-3 2000 Co-localization of various substances with catecholamines in the tumor, including neuropeptide Y, opioid peptides or adrenomedulOFF peptide elevating cAMP production, is recognized. Catecholamines 43-57 neuropeptide Y Homo sapiens 82-96 10834930-0 2000 Catecholamines up-regulate lipopolysaccharide-induced IL-6 production in human microvascular endothelial cells. Catecholamines 0-14 interleukin 6 Homo sapiens 54-58 10834930-2 2000 Whereas catecholamines decrease the LPS-induced production of IL-6 by leukocytes, serum levels of IL-6 are dramatically increased by the catecholamine epinephrine in animal endotoxemia models. Catecholamines 8-22 interferon regulatory factor 6 Homo sapiens 36-39 10834930-2 2000 Whereas catecholamines decrease the LPS-induced production of IL-6 by leukocytes, serum levels of IL-6 are dramatically increased by the catecholamine epinephrine in animal endotoxemia models. Catecholamines 8-22 interleukin 6 Homo sapiens 62-66 10834930-4 2000 Furthermore, these catecholamines could even potentiate the LPS-induced IL-6 protein production. Catecholamines 19-33 interferon regulatory factor 6 Homo sapiens 60-63 10834930-4 2000 Furthermore, these catecholamines could even potentiate the LPS-induced IL-6 protein production. Catecholamines 19-33 interleukin 6 Homo sapiens 72-76 10834930-6 2000 The catecholamine-induced IL-6 stimulation is based on increased IL-6 mRNA levels. Catecholamines 4-17 interleukin 6 Homo sapiens 26-30 10834930-6 2000 The catecholamine-induced IL-6 stimulation is based on increased IL-6 mRNA levels. Catecholamines 4-17 interleukin 6 Homo sapiens 65-69 10834930-10 2000 Thus, endothelial cells might be a possible source of increased IL-6 production observed in situations such as stress or septic shock, in which catecholamines are elevated due to endogenous production or exogenous application. Catecholamines 144-158 interleukin 6 Homo sapiens 64-68 10942111-8 2000 Since EMT and OCT2 may play important roles in catecholamine homeostasis and, as such, are candidate genes in human disease, the present results provide a basis for the analysis of genetic variation and the regulation of transcription. Catecholamines 47-60 solute carrier family 22 member 2 Homo sapiens 14-18 11021986-2 2000 We measured changes in extracellular concentrations of catecholamine and indoleamines in freely moving rats in response to administration of CRF1 antagonist CP-154,526 by using in vivo microdialysis. Catecholamines 55-68 corticotropin releasing hormone receptor 1 Rattus norvegicus 141-145 10713361-0 2000 Catecholamines trigger IL-10 release in acute systemic stress reaction by direct stimulation of its promoter/enhancer activity in monocytic cells. Catecholamines 0-14 interleukin 10 Homo sapiens 23-28 10713361-3 2000 Using reporter gene assays we demonstrated that catecholamines in monocytic cells directly stimulate the IL-10 promoter/enhancer via a cAMP/protein kinase A-dependent pathway. Catecholamines 48-62 interleukin 10 Homo sapiens 105-110 10877211-4 2000 These data suggest that the primary mechanism by which insulin stimulates leptin release is to blunt the inhibitory effects of beta1-adrenergic receptor agonists, and low concentrations of catecholamines actually enhance the stimulation of leptin release by insulin. Catecholamines 189-203 insulin Homo sapiens 258-265 10844099-0 2000 Facilitation and inhibition by endothelin-1 of adrenal catecholamine secretion in anesthetized dogs. Catecholamines 55-68 endothelin 1 Canis lupus familiaris 31-43 10748097-9 2000 Using permeabilized chromaffin cells, we found that the introduction of anti-ARNO antibodies into the cytosol inhibits, in a dose-dependent manner, both PLD activation and catecholamine secretion in calcium-stimulated cells. Catecholamines 172-185 cytohesin 2 Homo sapiens 77-81 10748097-6 2000 Both calcium-evoked PLD activation and catecholamine secretion in permeabilized cells are strongly inhibited by a synthetic peptide corresponding to the N-terminal domain of ARF6, suggesting that the ARF6-dependent PLD activation near the exocytotic sites represents a key event in the exocytotic reaction in chromaffin cells. Catecholamines 39-52 ADP ribosylation factor 6 Homo sapiens 174-178 10748097-6 2000 Both calcium-evoked PLD activation and catecholamine secretion in permeabilized cells are strongly inhibited by a synthetic peptide corresponding to the N-terminal domain of ARF6, suggesting that the ARF6-dependent PLD activation near the exocytotic sites represents a key event in the exocytotic reaction in chromaffin cells. Catecholamines 39-52 ADP ribosylation factor 6 Homo sapiens 200-204 10748097-6 2000 Both calcium-evoked PLD activation and catecholamine secretion in permeabilized cells are strongly inhibited by a synthetic peptide corresponding to the N-terminal domain of ARF6, suggesting that the ARF6-dependent PLD activation near the exocytotic sites represents a key event in the exocytotic reaction in chromaffin cells. Catecholamines 39-52 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 215-218 10844099-1 2000 We examined the participation of endothelin ET(A) and ET(B) receptors in modulation by endothelin-1 of adrenal catecholamine secretion during cholinergic activation in pentobarbital-anesthetized dogs. Catecholamines 111-124 endothelin 1 Canis lupus familiaris 87-99 10844099-4 2000 Endothelin-1 (0.2, 0.6, and 2 ng/kg/min) enhanced the catecholamine response induced by the 3-Hz nerve stimulation. Catecholamines 54-67 endothelin 1 Canis lupus familiaris 0-12 10844099-7 2000 These results suggest that in the dog adrenal gland, endothelin-1 facilitates and inhibits adrenal catecholamine secretion during cholinergic activation by stimulating endothelin ET(A) and ET(B) receptors, respectively. Catecholamines 99-112 endothelin 1 Canis lupus familiaris 53-65 10780953-3 2000 If epinephrine (Epi) infusion during moderate exercise were able to markedly stimulate R(a), this would support an important role for the catecholamines" response in IE. Catecholamines 138-152 tissue factor pathway inhibitor Homo sapiens 16-19 10834426-5 2000 RESULTS: During hyperglycemia, there were significant increments of systolic (sBP) (from 115.5 +/- 9.1 to 120.3 +/- 8.2 mmHg, P < 0.01) and diastolic (dBP) (from 70.3 +/- 7.8 to 79.7 +/- 5.3 mmHg, P < 0.01) blood pressure, as well as heart rate (from 75.2 +/- 7.8 to 80.8 +/- 5.4 beats/min, P < 0.01) and plasma catecholamines (P < 0.05). Catecholamines 321-335 selenium binding protein 1 Homo sapiens 78-81 10801302-4 2000 Plasma catecholamine concentrations significantly increased at 60 min after intracerebroventricular injection of leptin (control vs. 60 min; epinephrine: 33 +/- 12 vs. 97 +/- 27 pg/ml, P < 0.05; norepinephrine: 298 +/- 39 vs. 503 +/- 86 pg/ml, P < 0.05). Catecholamines 7-20 leptin Oryctolagus cuniculus 113-119 10731621-7 2000 Similarly, axons labeled for tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, were also present in high density in the granule cell layer of the same lobules of the vermis. Catecholamines 79-92 tyrosine hydroxylase Homo sapiens 29-49 10800925-1 2000 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines, which takes place in different types of neuronal systems and nonneuronal tissues. Catecholamines 77-91 tyrosine hydroxylase Mus musculus 0-20 10800925-1 2000 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines, which takes place in different types of neuronal systems and nonneuronal tissues. Catecholamines 77-91 tyrosine hydroxylase Mus musculus 22-24 10834306-0 2000 Effects of natriuretic peptides (ANP, BNP, CNP) on catecholamine synthesis and TH mRNA levels in PC12 cells. Catecholamines 51-64 natriuretic peptide C Rattus norvegicus 43-46 10769386-2 2000 Disruption of the NET gene in mice prolonged the clearance of NE and elevated extracellular levels of this catecholamine. Catecholamines 107-120 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 18-21 10834300-3 2000 Chronic L-dopa induces catechol-O-methyltransferase (COMT) and methionine adenosyl transferase (MAT), enzymes involved in the methylation of catecholamines (CA). Catecholamines 141-155 catechol-O-methyltransferase Homo sapiens 23-51 10834306-1 2000 Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are present in adrenal chromaffin cells, and are co-secreted with catecholamines suggesting that these natriuretic peptides (NPs) may modulate functions of chromaffin cells in an autocrine and/or paracrine manner. Catecholamines 169-183 natriuretic peptide A Rattus norvegicus 0-26 10834306-1 2000 Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are present in adrenal chromaffin cells, and are co-secreted with catecholamines suggesting that these natriuretic peptides (NPs) may modulate functions of chromaffin cells in an autocrine and/or paracrine manner. Catecholamines 169-183 natriuretic peptide B Rattus norvegicus 34-59 10834300-3 2000 Chronic L-dopa induces catechol-O-methyltransferase (COMT) and methionine adenosyl transferase (MAT), enzymes involved in the methylation of catecholamines (CA). Catecholamines 141-155 catechol-O-methyltransferase Homo sapiens 53-57 10834300-3 2000 Chronic L-dopa induces catechol-O-methyltransferase (COMT) and methionine adenosyl transferase (MAT), enzymes involved in the methylation of catecholamines (CA). Catecholamines 141-155 methionine adenosyltransferase 1A Homo sapiens 63-94 10834306-1 2000 Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are present in adrenal chromaffin cells, and are co-secreted with catecholamines suggesting that these natriuretic peptides (NPs) may modulate functions of chromaffin cells in an autocrine and/or paracrine manner. Catecholamines 169-183 natriuretic peptide B Rattus norvegicus 61-64 10834300-3 2000 Chronic L-dopa induces catechol-O-methyltransferase (COMT) and methionine adenosyl transferase (MAT), enzymes involved in the methylation of catecholamines (CA). Catecholamines 141-155 methionine adenosyltransferase 1A Homo sapiens 96-99 10834306-1 2000 Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are present in adrenal chromaffin cells, and are co-secreted with catecholamines suggesting that these natriuretic peptides (NPs) may modulate functions of chromaffin cells in an autocrine and/or paracrine manner. Catecholamines 169-183 natriuretic peptide C Rattus norvegicus 70-96 10834306-1 2000 Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are present in adrenal chromaffin cells, and are co-secreted with catecholamines suggesting that these natriuretic peptides (NPs) may modulate functions of chromaffin cells in an autocrine and/or paracrine manner. Catecholamines 169-183 natriuretic peptide C Rattus norvegicus 98-101 10834306-2 2000 Therefore, we investigated the effects of NPs on tyrosine hydroxylase (TH: a rate-limiting enzyme in biosynthesis of catecholamine) mRNA in rat pheochromocytoma PC12 cells. Catecholamines 117-130 tyrosine hydroxylase Rattus norvegicus 49-69 10834306-7 2000 Moreover, NPs were shown to induce significant increases of intracellular catecholamine contents (ANP= BNP> CNP). Catecholamines 74-87 natriuretic peptide B Rattus norvegicus 103-106 10834306-7 2000 Moreover, NPs were shown to induce significant increases of intracellular catecholamine contents (ANP= BNP> CNP). Catecholamines 74-87 natriuretic peptide C Rattus norvegicus 111-114 10809289-0 2000 Vasopressin decreases endogenous catecholamine plasma concentrations during cardiopulmonary resuscitation in pigs. Catecholamines 33-46 vasopressin Sus scrofa 0-11 10764411-8 2000 Microvascular catecholamine responsiveness and survival were improved in iNOS-deficient mice in a clinically relevant model of sepsis, suggesting that iNOS plays an important, but not exclusive, role in refractory vasodilation in patients with septic shock. Catecholamines 14-27 nitric oxide synthase 2, inducible Mus musculus 73-77 10764411-8 2000 Microvascular catecholamine responsiveness and survival were improved in iNOS-deficient mice in a clinically relevant model of sepsis, suggesting that iNOS plays an important, but not exclusive, role in refractory vasodilation in patients with septic shock. Catecholamines 14-27 nitric oxide synthase 2, inducible Mus musculus 151-155 10865122-10 2000 A peptide with amino acid sequence corresponding to the phosphorylation site domain of MARCKS, which also corresponds to its actin binding site, blocks PMA potentiation of Ca(2+)-induced catecholamine release. Catecholamines 187-200 myristoylated alanine rich protein kinase C substrate Homo sapiens 87-93 10809289-1 2000 OBJECTIVE: The purpose of this study was to evaluate the effect of vasopressin vs. saline placebo on catecholamine plasma concentrations during cardiopulmonary resuscitation (CPR). Catecholamines 101-114 vasopressin Sus scrofa 67-78 10809289-10 2000 CONCLUSIONS: Administration of vasopressin during CPR resulted in significantly superior vital organ blood flow, but significantly decreased endogenous catecholamine plasma concentrations when compared with placebo. Catecholamines 152-165 vasopressin Sus scrofa 31-42 10689270-7 2000 CONCLUSIONS: We conclude that the Gly16 beta(2)AR polymorphism imparts attenuated vasodilatory responses to catecholamines in normal human beings and is an important genetic component in the regulation of peripheral blood flow and systemic arterial pressure. Catecholamines 108-122 adrenoceptor beta 2 Homo sapiens 40-49 10823728-6 2000 These results suggest that oscillation stress induces IL-1beta mRNA expression in the liver and spleen, probably in Kupffer cells and splenic macrophages, and that stress-induced IL-1beta expression is elicited by catecholamines released from sympathetic nerve terminals and the adrenal gland. Catecholamines 214-228 interleukin 1 beta Rattus norvegicus 179-187 10719089-0 2000 Catecholamine degradation by monoamine oxidase in locus coeruleus neurons of the rat. Catecholamines 0-13 monoamine oxidase A Rattus norvegicus 29-46 10700013-2 2000 The principal aim of the present study was to determine whether pituitary adenylate cyclase activating peptide (PACAP), which is coreleased with acetylcholine from the splanchnic nerve, can modulate nicotinic receptor-dependent Ca(2+) signaling and catecholamine secretion in porcine adrenal medullary chromaffin (PAMC) cells. Catecholamines 249-262 adenylate cyclase activating polypeptide 1 Homo sapiens 64-110 10700013-2 2000 The principal aim of the present study was to determine whether pituitary adenylate cyclase activating peptide (PACAP), which is coreleased with acetylcholine from the splanchnic nerve, can modulate nicotinic receptor-dependent Ca(2+) signaling and catecholamine secretion in porcine adrenal medullary chromaffin (PAMC) cells. Catecholamines 249-262 adenylate cyclase activating polypeptide 1 Homo sapiens 112-117 10938545-1 2000 Tyrosine hydroxylase requires the regulatory cofactor, tetrahydrobiopterin, for catecholamine biosynthesis. Catecholamines 80-93 pale Drosophila melanogaster 0-20 10876805-3 2000 This mini-review focuses on the issues (1) how the immune system transmits information to the brain and (2) how pro-inflammatory cytokines, interleukin-1 in particular, alter the activities of monoamines (catecholamines and serotonin) and some peptides (CRF, alpha MSH) for the manifestation of acute phase responses. Catecholamines 205-219 interleukin 1 alpha Homo sapiens 140-153 10757529-3 2000 Depletion of neocortical serotonin or catecholamine afferents with selective neurotoxins resulted in a permanent alteration of the dendritic arborization of calretinin-containing interneurons, and a transient delay of parvalbumin and calbindin expression in a number of cortical neurones during the second postnatal week. Catecholamines 38-51 calbindin 2 Mus musculus 157-167 10757529-3 2000 Depletion of neocortical serotonin or catecholamine afferents with selective neurotoxins resulted in a permanent alteration of the dendritic arborization of calretinin-containing interneurons, and a transient delay of parvalbumin and calbindin expression in a number of cortical neurones during the second postnatal week. Catecholamines 38-51 parvalbumin Mus musculus 218-229 10757529-3 2000 Depletion of neocortical serotonin or catecholamine afferents with selective neurotoxins resulted in a permanent alteration of the dendritic arborization of calretinin-containing interneurons, and a transient delay of parvalbumin and calbindin expression in a number of cortical neurones during the second postnatal week. Catecholamines 38-51 calbindin 1 Mus musculus 234-243 10698161-1 2000 We had described that epidermal growth factor (EGF) interfered with the lipolytic effect of catecholamines in isolated adipocytes. Catecholamines 92-106 epidermal growth factor Mus musculus 22-45 10698161-1 2000 We had described that epidermal growth factor (EGF) interfered with the lipolytic effect of catecholamines in isolated adipocytes. Catecholamines 92-106 epidermal growth factor Mus musculus 47-50 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 tumor necrosis factor Homo sapiens 107-134 10786926-7 2000 These results suggest that the Trp64Arg mutant beta3-adrenergic receptor has less ability to stimulate adenylyl cyclase, and that lipolytic activity through the beta3-adrenergic receptor by catecholamines in subjects carrying this mutation might be suppressed. Catecholamines 190-204 adrenoceptor beta 3 Homo sapiens 47-72 10786926-7 2000 These results suggest that the Trp64Arg mutant beta3-adrenergic receptor has less ability to stimulate adenylyl cyclase, and that lipolytic activity through the beta3-adrenergic receptor by catecholamines in subjects carrying this mutation might be suppressed. Catecholamines 190-204 adrenoceptor beta 3 Homo sapiens 161-186 11343574-2 2000 Nerve growth factor (NGF), the first characterized member of the family of neurotrophins, influences the synthesis of some neuropeptides, including neuropeptide Y (NPY), a peptide amply expressed in the CNS, interacting with catecholamines and modifying behaviour. Catecholamines 225-239 nerve growth factor Rattus norvegicus 0-19 11343574-2 2000 Nerve growth factor (NGF), the first characterized member of the family of neurotrophins, influences the synthesis of some neuropeptides, including neuropeptide Y (NPY), a peptide amply expressed in the CNS, interacting with catecholamines and modifying behaviour. Catecholamines 225-239 nerve growth factor Rattus norvegicus 21-24 11343574-2 2000 Nerve growth factor (NGF), the first characterized member of the family of neurotrophins, influences the synthesis of some neuropeptides, including neuropeptide Y (NPY), a peptide amply expressed in the CNS, interacting with catecholamines and modifying behaviour. Catecholamines 225-239 neuropeptide Y Rattus norvegicus 148-162 11343574-2 2000 Nerve growth factor (NGF), the first characterized member of the family of neurotrophins, influences the synthesis of some neuropeptides, including neuropeptide Y (NPY), a peptide amply expressed in the CNS, interacting with catecholamines and modifying behaviour. Catecholamines 225-239 neuropeptide Y Rattus norvegicus 164-167 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 tumor necrosis factor Homo sapiens 136-139 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 interleukin 6 Homo sapiens 168-181 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 interleukin 6 Homo sapiens 183-187 10823386-3 2000 MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production. Catecholamines 14-28 interleukin 10 Homo sapiens 193-198 10671541-7 2000 A loss of the ability to translocate HSL to the lipid droplet probably contributes to the diminished lipolytic response to catecholamines with age. Catecholamines 123-137 lipase E, hormone sensitive type Rattus norvegicus 37-40 10793225-1 2000 Adrenomedullin (ADM) has been recently found to directly inhibit agonist-stimulated aldosterone secretion by dispersed zona glomerulosa (ZG) cells and to stimulate basal catecholamine release by adrenomedullary fragments. Catecholamines 170-183 adrenomedullin Rattus norvegicus 0-14 10726911-2 2000 Insulin has been shown to stimulate leptin secretion, whereas in vitro data suggest that catecholamines and free fatty acids (FFAs) inhibit leptin secretion. Catecholamines 89-103 leptin Homo sapiens 140-146 10671489-2 2000 Despite strong similarities in their activation mechanisms (e.g. they both undergo rapid hypoxia-induced protein stabilization, bind identical target DNA sequences, and induce synthetic reporter genes to similar degrees), they are both essential for embryo survival via distinct functions during vascularization (HIF-1alpha) or catecholamine production (HLF). Catecholamines 328-341 hypoxia inducible factor 1 subunit alpha Homo sapiens 313-323 10974417-11 2000 We conclude that the alpha(2)-AR-mediated vasoconstriction induced by catecholamines is attributable to the alpha(2A)-AR subtype because mice deficient in any one of the other subtypes retained the capacity for normal vasoconstrictive responses. Catecholamines 70-84 adrenergic receptor, alpha 2a Mus musculus 21-32 10719595-11 2000 Dopexamine, a synthetic catecholamine, induces vasodilation via beta 2-adrenoceptor stimulation and potentially increases splanchnic blood flow by additional effects on dopaminergic receptors. Catecholamines 24-37 adrenoceptor beta 2 Homo sapiens 64-83 10974417-11 2000 We conclude that the alpha(2)-AR-mediated vasoconstriction induced by catecholamines is attributable to the alpha(2A)-AR subtype because mice deficient in any one of the other subtypes retained the capacity for normal vasoconstrictive responses. Catecholamines 70-84 adrenergic receptor, alpha 2a Mus musculus 108-116 10644703-5 2000 In addition, a peptide corresponding to the target sequence of K-20 blocked the action of the catecholamine, apparently by competition between the peptide and G(s) for activated beta-adrenergic receptors, indicating that the G protein betagamma-subunits mediating the inhibitory effects of the catecholamine were in fact derived from G(s). Catecholamines 94-107 keratin 20 Homo sapiens 63-67 10688962-9 2000 Collectively, the present findings allow us to conclude that cerebellin 1) directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and 2) indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. Catecholamines 288-301 cerebellin 1 precursor Rattus norvegicus 61-73 10718909-14 2000 The fall in plasma leptin concentration after insulin-induced hypoglycaemia may reflect catecholamine secretion after this stimulus. Catecholamines 88-101 leptin Homo sapiens 19-25 10644703-5 2000 In addition, a peptide corresponding to the target sequence of K-20 blocked the action of the catecholamine, apparently by competition between the peptide and G(s) for activated beta-adrenergic receptors, indicating that the G protein betagamma-subunits mediating the inhibitory effects of the catecholamine were in fact derived from G(s). Catecholamines 294-307 keratin 20 Homo sapiens 63-67 10620706-1 2000 Tyrosine hydroxylase (TH), which converts L-tyrosine to L-3, 4-dihydroxyphenylalanine, is a rate-limiting enzyme in the biosynthesis of catecholamines; its activity is regulated by the feedback inhibition of the catecholamine products including dopamine. Catecholamines 136-149 tyrosine hydroxylase Homo sapiens 0-20 10661499-0 2000 C-fos gene expression in rat brain around birth: effect of asphyxia and catecholamines. Catecholamines 72-86 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 10661499-11 2000 Therefore, we propose that while catecholamines play an important role in the induction of c-fos in the brain at birth, the effects of asphyxia involve a different mechanism. Catecholamines 33-47 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 91-96 10800597-9 2000 Tyrosine hydroxylase is regulated by phosphorylation and feedback inhibition by catecholamines. Catecholamines 80-94 tyrosine hydroxylase Homo sapiens 0-20 11192604-0 2000 Regulation of chromogranin A transcription and catecholamine secretion by the neuropeptide PACAP. Catecholamines 47-60 adenylate cyclase activating polypeptide 1 Homo sapiens 91-96 10849669-3 2000 Previous studies have shown that hypoxia up-regulates c-fos, an immediate early gene, and tyrosine hydroxylase (TH), a late response gene that encodes rate limiting enzyme in catecholamine synthesis. Catecholamines 175-188 tyrosine hydroxylase Rattus norvegicus 90-110 10620706-1 2000 Tyrosine hydroxylase (TH), which converts L-tyrosine to L-3, 4-dihydroxyphenylalanine, is a rate-limiting enzyme in the biosynthesis of catecholamines; its activity is regulated by the feedback inhibition of the catecholamine products including dopamine. Catecholamines 136-150 tyrosine hydroxylase Homo sapiens 0-20 11268388-5 2000 The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta. Catecholamines 4-18 interleukin 6 Homo sapiens 64-68 10842896-2 2000 Angiotensin II causes a variety of potentially noxious biological effects, such as vasoconstriction, a rise in blood pressure, release of aldosterone, enhancement of the effect of catecholamines, and vascular and myocardial hypertrophy, including remodeling of the heart after myocardial infarction. Catecholamines 180-194 angiotensinogen Homo sapiens 0-14 10849669-3 2000 Previous studies have shown that hypoxia up-regulates c-fos, an immediate early gene, and tyrosine hydroxylase (TH), a late response gene that encodes rate limiting enzyme in catecholamine synthesis. Catecholamines 175-188 tyrosine hydroxylase Rattus norvegicus 112-114 11193870-6 2000 These data, together with the observation that PACAP receptors are exclusively located on chromaffin cells, suggest that, in the fetal human adrenal gland, the effect of PACAP on steroid secretion is mediated via the local release of catecholamines. Catecholamines 234-248 adenylate cyclase activating polypeptide 1 Homo sapiens 170-175 11268388-5 2000 The catecholamines and serotonin also synergistically stimulate IL-6 release in the presence of IL-1 beta. Catecholamines 4-18 interleukin 1 beta Homo sapiens 96-105 11193127-1 2000 OBJECTIVE: We have studied possible association between predisposition to essential hypertension, plasma noradrenaline level and two polymorphisms of the gene for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 218-231 tyrosine hydroxylase Homo sapiens 163-183 11193127-1 2000 OBJECTIVE: We have studied possible association between predisposition to essential hypertension, plasma noradrenaline level and two polymorphisms of the gene for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 218-231 tyrosine hydroxylase Homo sapiens 185-187 10844400-5 2000 The possible role of vimentin in secretion was in addition investigated using digitonin-permeabilized cells, in which the specific antibody for vimentin partially inhibited calcium-induced catecholamine release. Catecholamines 189-202 vimentin Homo sapiens 144-152 11388023-1 2000 The characterization in 1989 of the gene encoding the beta 3-adrenoceptor helped to interpret the results of pharmacological experiments on atypical effects of catecholamines distinct from the classical activation of beta 1 and beta 2 adrenoceptors. Catecholamines 160-174 adrenoceptor beta 3 Homo sapiens 54-73 10683300-2 2000 In transplanted adrenal medullary cells in vivo, TH mRNA and TH immunoreactivity are still apparent for at least 1 year after transplantation, indicating continued capacity for catecholamine biosynthesis. Catecholamines 177-190 tyrosine hydroxylase Rattus norvegicus 49-51 10667533-8 2000 MEASUREMENTS AND MAIN RESULTS: Vasopressin (0.03-0.07 units/min) increased systolic arterial pressure from 90+/-4.7 to 130+/-2.3 mm Hg while reducing the administration of catecholamine pressors. Catecholamines 172-185 arginine vasopressin Homo sapiens 31-42 10614636-4 2000 NPY also stimulated the release of catecholamines from intact rat adrenal capsular tissue with the same dose-dependent relationship as the stimulation of aldosterone release. Catecholamines 35-49 neuropeptide Y Rattus norvegicus 0-3 10614636-5 2000 These observations suggest that the actions of NPY may be mediated by the local release of catecholamines from chromaffin cells within adrenal capsular tissue, as we have previously described for vasoactive intestinal peptide. Catecholamines 91-105 neuropeptide Y Rattus norvegicus 47-50 11117672-3 2000 Insulin resistance in PCOS adipocytes was manifested as a reduction in insulin sensitivities for stimulation of glucose transport and suppression of catecholamine-activated lipolysis with no impact on final hormone responsiveness. Catecholamines 149-162 insulin Homo sapiens 0-7 11129104-1 2000 The organic cation transporter 3 (OCT3), also termed as extraneuronal monoamine transporter (EMT), is known to be expressed in glial cells where it is responsible for the uptake of catecholamines and neurotoxic organic cations such as 1-methyl-4-phenylpyridinium (MPP+). Catecholamines 181-195 OCTN3 Homo sapiens 4-32 11129104-1 2000 The organic cation transporter 3 (OCT3), also termed as extraneuronal monoamine transporter (EMT), is known to be expressed in glial cells where it is responsible for the uptake of catecholamines and neurotoxic organic cations such as 1-methyl-4-phenylpyridinium (MPP+). Catecholamines 181-195 OCTN3 Homo sapiens 34-38 10721683-1 2000 OBJECTIVE: To investigate the effect of amitriptyline, bupropion, doxepin or venlafaxine on the gene expression of the neuroprotective enzyme superoxide dismutase (SOD1) in a catecholamine cell in vitro model. Catecholamines 175-188 superoxide dismutase 1 Rattus norvegicus 164-168 11117672-3 2000 Insulin resistance in PCOS adipocytes was manifested as a reduction in insulin sensitivities for stimulation of glucose transport and suppression of catecholamine-activated lipolysis with no impact on final hormone responsiveness. Catecholamines 149-162 insulin Homo sapiens 71-78 10658630-10 2000 Furthermore, double-labelling for tyrosine hydroxylase immunoreactivity demonstrated that neurons in the ventrolateral medulla that expressed Fos following hypovolaemia were predominantly catecholamine cells, whereas following hypervolaemia they were predominantly non-catecholamine cells. Catecholamines 188-201 proto-oncogene c-Fos Oryctolagus cuniculus 142-145 11124582-9 2000 Taken together, these findings suggest that acute stress, by releasing catecholamines from the adrenal glands and activating beta(1)- and beta(2)-adrenoceptors, suppresses NKA and consequently compromises resistance to NK-sensitive metastasis. Catecholamines 71-85 Natural killer alloreactivity QTL 1 Rattus norvegicus 172-175 11147460-1 2000 In this study, we attempted to test whether tyrosine hydroxylase (TH), the first rate-limiting enzyme of catecholamine synthesis, is confined to the perikarya of activated magnocellular vasopressinergic (VPergic) neurons or is also present in their distal axons in the pituitary posterior lobe (PL). Catecholamines 105-118 tyrosine hydroxylase Rattus norvegicus 44-64 10658630-10 2000 Furthermore, double-labelling for tyrosine hydroxylase immunoreactivity demonstrated that neurons in the ventrolateral medulla that expressed Fos following hypovolaemia were predominantly catecholamine cells, whereas following hypervolaemia they were predominantly non-catecholamine cells. Catecholamines 269-282 proto-oncogene c-Fos Oryctolagus cuniculus 142-145 10716222-4 1999 After hemorrhage most Fos-positive catecholamine cells were found below obex whereas most hypoxia-responsive cells were rostral to obex. Catecholamines 35-48 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 22-25 10700082-13 1999 Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h. CONCLUSIONS: The first peak of catecholamine and corticosterone levels might result from unspecific stressor associated with the surgery. Catecholamines 176-189 phenylethanolamine-N-methyltransferase Rattus norvegicus 8-47 10606440-6 1999 It is concluded that both beta1AR and beta2AR mediate positive chronotropic effects of catecholamines on rat and mouse atria but only beta2AR are constitutively active. Catecholamines 87-101 adrenergic receptor, beta 2 Mus musculus 38-45 10585338-1 1999 BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine. Catecholamines 98-112 tyrosine hydroxylase Homo sapiens 12-32 10585338-1 1999 BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine. Catecholamines 98-112 tyrosine hydroxylase Homo sapiens 34-36 10602322-0 1999 Effect of Gd3+ on bradykinin-induced catecholamine secretion from bovine adrenal chromaffin cells. Catecholamines 37-50 kininogen 1 Bos taurus 18-28 10700082-13 1999 Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h. CONCLUSIONS: The first peak of catecholamine and corticosterone levels might result from unspecific stressor associated with the surgery. Catecholamines 176-189 phenylethanolamine-N-methyltransferase Rattus norvegicus 49-53 10582617-4 1999 We measured the oxidation of the catecholamine by following the binding of [3H]DA to the sulfhydryl-rich protein alcohol dehydrogenase. Catecholamines 33-46 aldo-keto reductase family 1 member A1 Homo sapiens 113-134 10619567-2 1999 Regional specificity of this BDNF mutation was assessed by assaying catecholamine concentrations within the corpus striatum, hypothalamus, and olfactory bulbs. Catecholamines 68-81 brain derived neurotrophic factor Mus musculus 29-33 10619567-12 1999 These latter findings may indicate some subtle changes in catecholamine functions resulting from a heterozygous BDNF mutation. Catecholamines 58-71 brain derived neurotrophic factor Mus musculus 112-116 10582619-2 1999 GTP-CH catalyses the first step in the biosynthesis of tetrahydrobiopterin (BH4), a cofactor necessary for the synthesis of catecholamines and serotonin. Catecholamines 124-138 GTP cyclohydrolase 1 Mus musculus 0-6 10580084-2 1999 EPAS1 is a hypoxia-inducible transcription factor, highly expressed in vasculature and recently shown to be necessary for catecholamine production during embryogenesis. Catecholamines 122-135 endothelial PAS domain protein 1 Gallus gallus 0-5 10619177-0 1999 Pharmacological characterization of receptor-mediated Ca2+ entry in endothelin-1-induced catecholamine release from cultured bovine adrenal chromaffin cells. Catecholamines 89-102 endothelin 1 Bos taurus 68-80 10619177-2 1999 ET-1 but not ET-3 induced increases in release of catecholamines, [Ca2+]i, and 45Ca2+ uptake. Catecholamines 50-64 endothelin 1 Bos taurus 0-4 10619177-6 1999 These results indicate that ET-1 augments the release of catecholamines from adrenal chromaffin cells through ET(A) receptors, by activating two types of Ca2+ entry channels in addition to L-type VOCC: one (nonselective cation channel-1; NSCC-1) is sensitive to LOE 908 but resistant to SK&F 96365, whereas the other (NSCC-2) is sensitive to both LOE 908 and SK&F 96365. Catecholamines 57-71 endothelin 1 Bos taurus 28-32 10588509-1 1999 Studies performed on healthy volunteers have revealed that catecholamines down-regulate the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)alpha, interleukin (IL)-6, and IL-1beta. Catecholamines 59-73 tumor necrosis factor Homo sapiens 139-160 10588509-1 1999 Studies performed on healthy volunteers have revealed that catecholamines down-regulate the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)alpha, interleukin (IL)-6, and IL-1beta. Catecholamines 59-73 tumor necrosis factor Homo sapiens 162-171 10588509-1 1999 Studies performed on healthy volunteers have revealed that catecholamines down-regulate the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)alpha, interleukin (IL)-6, and IL-1beta. Catecholamines 59-73 interleukin 6 Homo sapiens 173-191 10588509-1 1999 Studies performed on healthy volunteers have revealed that catecholamines down-regulate the lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)alpha, interleukin (IL)-6, and IL-1beta. Catecholamines 59-73 interleukin 1 beta Homo sapiens 197-205 10588509-7 1999 Correspondingly, in blood of patients with prolonged severe sepsis, TNFalpha was reduced by 67.2% (P < 0.0001) and IL-6 was reduced by 32.9% (P < 0.0001); IL-1beta and IL-10 were not modulated by catecholamines in these patients. Catecholamines 202-216 tumor necrosis factor Homo sapiens 68-76 10588509-7 1999 Correspondingly, in blood of patients with prolonged severe sepsis, TNFalpha was reduced by 67.2% (P < 0.0001) and IL-6 was reduced by 32.9% (P < 0.0001); IL-1beta and IL-10 were not modulated by catecholamines in these patients. Catecholamines 202-216 interleukin 6 Homo sapiens 118-122 10593508-6 1999 Collectively, our results suggest that the changes in mitogen-induced proliferative responses in the peripheral blood and spleen of prenatally cypermethrin-exposed rats may be attributable to pesticide-induced catecholamine release, which causes an increased output of CD5+, CD4+, and CD8+ T cells from the spleen to the peripheral blood, and a consequent lymphocytosis. Catecholamines 210-223 Cd5 molecule Rattus norvegicus 269-272 10593508-6 1999 Collectively, our results suggest that the changes in mitogen-induced proliferative responses in the peripheral blood and spleen of prenatally cypermethrin-exposed rats may be attributable to pesticide-induced catecholamine release, which causes an increased output of CD5+, CD4+, and CD8+ T cells from the spleen to the peripheral blood, and a consequent lymphocytosis. Catecholamines 210-223 Cd4 molecule Rattus norvegicus 275-278 10593508-3 1999 The enhancement of plasma catecholamine levels was accompanied by a marked increase of CD5+, CD4+, and CD8+ total T cell numbers in the peripheral blood, while in the spleen a reduction of all T cell subsets was observed. Catecholamines 26-39 Cd5 molecule Rattus norvegicus 87-90 10644007-0 1999 Macrophage migration inhibitory factor (MIF)--its role in catecholamine metabolism. Catecholamines 58-71 macrophage migration inhibitory factor Homo sapiens 0-38 10593508-3 1999 The enhancement of plasma catecholamine levels was accompanied by a marked increase of CD5+, CD4+, and CD8+ total T cell numbers in the peripheral blood, while in the spleen a reduction of all T cell subsets was observed. Catecholamines 26-39 Cd4 molecule Rattus norvegicus 93-96 10567311-9 1999 In these patients, low-dose vasopressin significantly increases blood pressure with a pressor response sufficient to reduce catecholamine administration. Catecholamines 124-137 arginine vasopressin Homo sapiens 28-39 10593661-0 1999 Functional role of local angiotensin-converting enzyme (ACE) in adrenal catecholamine secretion in vivo. Catecholamines 72-85 angiotensin I converting enzyme Canis lupus familiaris 25-54 10593661-0 1999 Functional role of local angiotensin-converting enzyme (ACE) in adrenal catecholamine secretion in vivo. Catecholamines 72-85 angiotensin I converting enzyme Canis lupus familiaris 56-59 10644007-0 1999 Macrophage migration inhibitory factor (MIF)--its role in catecholamine metabolism. Catecholamines 58-71 macrophage migration inhibitory factor Homo sapiens 40-43 10644007-4 1999 Since MIF is highly expressed in human brain, these observations raise the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have an important role for neural tissues. Catecholamines 141-154 macrophage migration inhibitory factor Homo sapiens 6-9 10644007-4 1999 Since MIF is highly expressed in human brain, these observations raise the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have an important role for neural tissues. Catecholamines 141-154 macrophage migration inhibitory factor Homo sapiens 92-95 10644007-5 1999 The potential role of MIF in the formation of neuromelanin from catecholamines is also an extremely interesting possibility. Catecholamines 64-78 macrophage migration inhibitory factor Homo sapiens 22-25 10562636-5 1999 An increased catecholamine synthesis was indicated by the raised (P < 0.05) plasma dopamine beta-hydroxylase activity at 3 days, but this was decreased (P < 0. Catecholamines 13-26 dopamine beta-hydroxylase Rattus norvegicus 86-111 10545100-8 1999 However, replacement of the two arginines abolished the ability of the GTP-bound form of Rab3 to inhibit exocytosis of catecholamine- and insulin-secreting cells. Catecholamines 119-132 RAB3A, member RAS oncogene family Rattus norvegicus 89-93 10619437-13 1999 In this scenario the catecholamine-induced release of the potent anti-inflammatory cytokine interleukin-10 is a newly discovered mechanism of the brain-mediated monocyte deactivation in addition to the "well known" immunosuppressive action of glucocorticoids. Catecholamines 21-34 interleukin 10 Homo sapiens 92-106 10566656-14 1999 In conclusion, we provide evidence for a reciprocal regulation of PAI-1 by dexamethasone (positive effector) and cAMP/catecholamines (negative effectors) in cultured human adipose tissue. Catecholamines 118-132 serpin family E member 1 Homo sapiens 66-71 10634688-1 1999 Single and double-label immunofluorescence methods were used to determine the distribution and patterns of colocalisation of various neuropeptides and nitric oxide synthase (NOS) with the catecholamine synthesising enzymes tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DbetaH) in nerve fibres within specimens of adult human vas deferens obtained at vasectomy (age range 28 to 83 y). Catecholamines 188-201 nitric oxide synthase 2 Homo sapiens 151-172 10634688-1 1999 Single and double-label immunofluorescence methods were used to determine the distribution and patterns of colocalisation of various neuropeptides and nitric oxide synthase (NOS) with the catecholamine synthesising enzymes tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DbetaH) in nerve fibres within specimens of adult human vas deferens obtained at vasectomy (age range 28 to 83 y). Catecholamines 188-201 tyrosine hydroxylase Homo sapiens 223-243 10516661-2 1999 We examined the existence of catecholamine metabolizing enzymes (catechol-O-methyltransferase, COMT, and monoamine oxidase, MAO) in CHO cells transfected with norepinephrine (NE) transporter (NET) cDNA. Catecholamines 29-42 catechol-O-methyltransferase Homo sapiens 65-93 10543947-3 1999 SULT1A3 specifically sulfonates catecholamines such as dopamine, adrenaline and noradrenaline. Catecholamines 32-46 sulfotransferase family 1A member 3 Homo sapiens 0-7 10490696-1 1999 Catechol-O-methyltransferase (COMT) catalyzes the degradation of catecholamines and could therefore play a role in the etiology of schizophrenia. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 0-28 10490696-1 1999 Catechol-O-methyltransferase (COMT) catalyzes the degradation of catecholamines and could therefore play a role in the etiology of schizophrenia. Catecholamines 65-79 catechol-O-methyltransferase Homo sapiens 30-34 10490711-1 1999 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the metabolism of catecholamines, is considered a candidate gene in bipolar affective disorder (BPAD) and has been the subject of numerous linkage and association studies. Catecholamines 73-87 tyrosine hydroxylase Homo sapiens 0-20 10490711-1 1999 Tyrosine hydroxylase (TH), the rate-limiting enzyme in the metabolism of catecholamines, is considered a candidate gene in bipolar affective disorder (BPAD) and has been the subject of numerous linkage and association studies. Catecholamines 73-87 tyrosine hydroxylase Homo sapiens 22-24 10514498-2 1999 These proteins have opposing effects on regulating expression of the gene encoding tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 138-151 tyrosine hydroxylase Rattus norvegicus 83-103 10514498-2 1999 These proteins have opposing effects on regulating expression of the gene encoding tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 138-151 tyrosine hydroxylase Rattus norvegicus 105-107 10477896-3 1999 The use of micellar solutions as mobile phases in reversed-phase liquid chromatography (micellar liquid chromatography, MLC) has proven to be valid in the prediction of the biological activities of local anesthetics, catecholamines and barbiturates. Catecholamines 217-231 modulator of VRAC current 1 Homo sapiens 120-123 10513832-1 1999 The aim of this study was to evaluate plasma levels of ANF in patients with catecholamine-secreting tumors with and without hypertension and to relate ANF secretion to levels of plasma and urinary catecholamines and blood pressure. Catecholamines 76-89 natriuretic peptide A Homo sapiens 55-58 10513832-12 1999 The significance of the relationships among plasma ANF and urinary and plasma catecholamines requires further investigation. Catecholamines 78-92 natriuretic peptide A Homo sapiens 51-54 10516661-2 1999 We examined the existence of catecholamine metabolizing enzymes (catechol-O-methyltransferase, COMT, and monoamine oxidase, MAO) in CHO cells transfected with norepinephrine (NE) transporter (NET) cDNA. Catecholamines 29-42 catechol-O-methyltransferase Homo sapiens 95-99 10480609-9 1999 The present study provides evidence that a leptin-induced increase in catecholamine secretion is mediated primarily via the VMH and suggests the presence of distinct hypothalamic pathways mediating the satiety effect and sympathetic activation of leptin. Catecholamines 70-83 leptin Rattus norvegicus 43-49 10528604-10 1999 CONCLUSION: A VP infusion improved arterial pressure and permitted the withdrawal of catecholamine vasopressors. Catecholamines 85-98 arginine vasopressin Homo sapiens 14-16 10525427-2 1999 Adenosine inhibits catecholamine-induced increase in contractile function mainly through inhibition of phosphorylation of phospholamban (PLB), the main regulatory protein of Ca(2+)-ATPase in sarcoplasmic reticulum (SR), and during ischemia it reduces calcium (Ca2+) overload. Catecholamines 19-32 phospholamban Homo sapiens 137-140 10509627-5 1999 Selective inhibition of inducible iNOS with topical SMT (100 microM) markedly increased catecholamine reactivity in mice with sepsis but did not affect reactivity in controls (P=0.0007 for sepsis, P=0.24 for controls). Catecholamines 88-101 nitric oxide synthase 2, inducible Mus musculus 34-38 10509627-8 1999 These experiments demonstrate that iNOS inhibition is as effective as nonselective NOS inhibition in reversing decreased catecholamine reactivity in sepsis. Catecholamines 121-134 nitric oxide synthase 2, inducible Mus musculus 35-39 10480609-0 1999 Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Catecholamines 95-108 leptin Rattus norvegicus 26-32 10502665-7 1999 These "non-surviving" TRH-treated lambs had very high plasma catecholamine concentrations, but their lung weights were similar to controls. Catecholamines 61-74 LOW QUALITY PROTEIN: thyrotropin-releasing hormone Ovis aries 22-25 10480609-0 1999 Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Catecholamines 95-108 leptin Rattus norvegicus 68-74 10480609-3 1999 To explore the hypothalamic pathway of sympathetic activation of leptin, we examined the effects of a single intravenous or intracerebroventricular injection of recombinant human leptin on catecholamine secretion in rats. Catecholamines 189-202 leptin Homo sapiens 179-185 10471719-0 1999 The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity. Catecholamines 4-18 Catecholamines up Drosophila melanogaster 23-29 10471719-1 1999 We report the genetic, phenotypic, and biochemical analyses of Catecholamines up (Catsup), a gene that encodes a negative regulator of tyrosine hydroxylase (TH) activity. Catecholamines 63-77 Catecholamines up Drosophila melanogaster 82-88 10471719-5 1999 The hyperactivation of TH in Catsup mutants results in abnormally high levels of catecholamines, which can account for the lethality, visible phenotypes, and female sterility observed in these mutants. Catecholamines 81-95 Catecholamines up Drosophila melanogaster 29-35 10471719-6 1999 We propose that Catsup is a component of a novel system that downregulates TH activity, making Catsup the fourth locus found within the Dopa decarboxylase (Ddc) gene cluster that functions in catecholamine metabolism. Catecholamines 192-205 Catecholamines up Drosophila melanogaster 16-22 10471719-6 1999 We propose that Catsup is a component of a novel system that downregulates TH activity, making Catsup the fourth locus found within the Dopa decarboxylase (Ddc) gene cluster that functions in catecholamine metabolism. Catecholamines 192-205 Catecholamines up Drosophila melanogaster 95-101 10471719-6 1999 We propose that Catsup is a component of a novel system that downregulates TH activity, making Catsup the fourth locus found within the Dopa decarboxylase (Ddc) gene cluster that functions in catecholamine metabolism. Catecholamines 192-205 Dopa decarboxylase Drosophila melanogaster 136-154 10471719-6 1999 We propose that Catsup is a component of a novel system that downregulates TH activity, making Catsup the fourth locus found within the Dopa decarboxylase (Ddc) gene cluster that functions in catecholamine metabolism. Catecholamines 192-205 Dopa decarboxylase Drosophila melanogaster 156-159 10580367-8 1999 Furthermore, the IL-1beta-induced elevations of plasma catecholamines in these pinealectomized animals were attenuated by i.c.v. Catecholamines 55-69 interleukin 1 beta Rattus norvegicus 17-25 10460244-5 1999 When either of two different anti-CAPS IgGs or their Fab fragments were present, a rapid and progressive inhibition of catecholamine release ensued to a maximum of >80%. Catecholamines 119-132 calcyphosine Bos taurus 34-38 10460244-10 1999 These results suggest that CAPS is a key component regulating the fusion of DCVs to the plasma membrane, and possibly fusion pore dilation, in catecholamine secretion from AC cells. Catecholamines 143-156 calcyphosine Bos taurus 27-31 10465343-6 1999 We determined the erythrocyte SOD activity using the catecholamine oxidation method. Catecholamines 53-66 superoxide dismutase 1 Homo sapiens 30-33 10810557-10 1999 It was suggested that SP colocalized with ACh in splanchnic nerves functions as a physiological modulator of catecholamine secretion by non-competitively suppressing ACh-induced cytosolic Ca2+ dynamics in bovine adrenal chromaffin cells. Catecholamines 109-122 tachykinin precursor 1 Bos taurus 22-24 10515428-3 1999 The mechanism of action for PACAP 1-27 and 1-38 in vivo involves endogenous catecholamines, peptidases and nitric oxide, depending on tissue type. Catecholamines 76-90 adenylate cyclase activating polypeptide 1 Homo sapiens 28-33 10425201-0 1999 Leptin directly stimulates catecholamine secretion and synthesis in cultured porcine adrenal medullary chromaffin cells. Catecholamines 27-40 leptin Mus musculus 0-6 10425201-4 1999 Therefore, we investigated the effects of leptin on catecholamine secretion and synthesis in cultured porcine adrenal medullary chromaffin cells. Catecholamines 52-65 leptin Mus musculus 42-48 10425201-9 1999 Leptin (1, 10, 100 nM) significantly increased tyrosine hydroxylase (TH) (a rate-limiting enzyme in the biosynthesis of catecholamine) mRNA levels in a concentration-dependent manner. Catecholamines 120-133 leptin Mus musculus 0-6 10425201-9 1999 Leptin (1, 10, 100 nM) significantly increased tyrosine hydroxylase (TH) (a rate-limiting enzyme in the biosynthesis of catecholamine) mRNA levels in a concentration-dependent manner. Catecholamines 120-133 tyrosine hydroxylase Mus musculus 47-67 10425201-9 1999 Leptin (1, 10, 100 nM) significantly increased tyrosine hydroxylase (TH) (a rate-limiting enzyme in the biosynthesis of catecholamine) mRNA levels in a concentration-dependent manner. Catecholamines 120-133 tyrosine hydroxylase Mus musculus 69-71 10425201-11 1999 These results indicate that leptin directly stimulates catecholamine release and synthesis, which in turn may potentiate the anti-obesity effects of leptin. Catecholamines 55-68 leptin Mus musculus 28-34 10425201-11 1999 These results indicate that leptin directly stimulates catecholamine release and synthesis, which in turn may potentiate the anti-obesity effects of leptin. Catecholamines 55-68 leptin Mus musculus 149-155 10450274-1 1999 OBJECTIVE: Catechol O-methyltransferase (COMT) is involved in the degradation of catecholamine neurotransmitters. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 11-39 10450274-1 1999 OBJECTIVE: Catechol O-methyltransferase (COMT) is involved in the degradation of catecholamine neurotransmitters. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 41-45 10810557-1 1999 Substance P (SP) is colocalized with ACh in splanchnic nerves that innervate into adrenal medulla and the peptide has been shown to inhibit nicotinic agonists-induced catecholamine secretion. Catecholamines 167-180 tachykinin precursor 1 Bos taurus 0-11 10810557-1 1999 Substance P (SP) is colocalized with ACh in splanchnic nerves that innervate into adrenal medulla and the peptide has been shown to inhibit nicotinic agonists-induced catecholamine secretion. Catecholamines 167-180 tachykinin precursor 1 Bos taurus 13-15 10444371-8 1999 These results suggest that nitric oxide in the adrenal medulla may enhance the catecholamine biosynthetic pathway via increased TH mRNA expression. Catecholamines 79-92 tyrosine hydroxylase Rattus norvegicus 128-130 10476677-2 1999 We have employed buoyant density fractionation to separate the dopaminergic neurons of the two compartments and compare their subsequent phenotype development with respect to their expression of the gene encoding tyrosine hydroxylase, the rate-limiting enzyme in the catecholamine biosynthetic pathway. Catecholamines 267-280 tyrosine hydroxylase Rattus norvegicus 213-233 10462102-1 1999 In vivo release of catecholamines in the medial basal hypothalamus (MBH) by L-deprenyl, a monoamine oxidase-B (MAO-B) inhibitor, was measured in young male Sprague-Dawley rats with stereotaxically implanted push-pull cannulae in the MBH and perfused with 0 (control), 1.5, 2.5 or 10.0 microg deprenyl in 20 microl of saline. Catecholamines 19-33 monoamine oxidase B Rattus norvegicus 111-116 10440090-4 1999 In the presence of propranolol (1 microM), however, a non-selective beta1-, beta2- and beta3-adrenoceptor antagonist bupranolol caused a concentration-dependent rightward shift of the concentration-response curves for catecholamines and beta3-adrenoceptor agonists. Catecholamines 218-232 beta-2 adrenergic receptor Cavia porcellus 68-105 10440090-4 1999 In the presence of propranolol (1 microM), however, a non-selective beta1-, beta2- and beta3-adrenoceptor antagonist bupranolol caused a concentration-dependent rightward shift of the concentration-response curves for catecholamines and beta3-adrenoceptor agonists. Catecholamines 218-232 beta-3 adrenergic receptor Cavia porcellus 87-105 10432216-1 1999 The present study was undertaken to investigate the effects of ginsenosides on bovine adrenal tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 149-162 tyrosine hydroxylase Bos taurus 94-114 10432216-1 1999 The present study was undertaken to investigate the effects of ginsenosides on bovine adrenal tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 149-162 tyrosine hydroxylase Bos taurus 116-118 10375648-7 1999 It was concluded that the Cd2+-induced membrane depolarization due to the decrease in K+ conductances evoked the bursting firings resulting in the increase in [Ca]i, and consequently might stimulate the catecholamine secretion. Catecholamines 203-216 CD2 molecule Canis lupus familiaris 26-29 10385681-1 1999 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic catechols and catecholamines. Catecholamines 135-149 catechol-O-methyltransferase Homo sapiens 0-28 10381897-11 1999 We found that in vivo TFPI gene transfer into an injured artery completely inhibits the recurrent thrombosis induced by shear stress even in the presence of catecholamine, without affecting systemic coagulation status. Catecholamines 157-170 tissue factor pathway inhibitor Homo sapiens 22-26 10415589-2 1999 We recently demonstrated that catecholamines and histamine potently inhibited interleukin (IL)-12 and stimulated IL-10, whereas glucocorticoids suppressed IL-12, but did not affect IL-10 production ex vivo. Catecholamines 30-44 interleukin 10 Homo sapiens 113-118 10385681-1 1999 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme that is crucial to the metabolism of carcinogenic catechols and catecholamines. Catecholamines 135-149 catechol-O-methyltransferase Homo sapiens 30-34 10353260-8 1999 These results, demonstrating cross-talk in the neurotensin and beta-adrenergic signaling pathways, suggest that there may be other physiologic instances of similar interactions between neurotensin and catecholamines. Catecholamines 201-215 neurotensin Homo sapiens 47-58 10347189-0 1999 Phe310 in transmembrane VI of the alpha1B-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding. Catecholamines 113-126 adrenoceptor alpha 1B Homo sapiens 34-61 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 0-28 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 30-34 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 88-92 10454120-5 1999 This UCP is activated by fatty acids and its synthesis is positively controlled by retinoids, thyroid hormones, catecholamines and rexinoids. Catecholamines 112-126 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 5-8 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. Catecholamines 165-179 catechol-O-methyltransferase Rattus norvegicus 88-92 10537229-13 1999 These results confirm that a heterogenous beta-AR population mediating the chronotropic response to catecholamines can be demonstrated in right atria from foot shock stressed female rats sacrificed at diestrus. Catecholamines 100-114 adrenoceptor beta 2 Rattus norvegicus 42-49 10484286-2 1999 The objective of the present study was to investigate the effects of L-deprenyl, a monoamine oxidase-B (MAO-B) inhibitor, treatment on the development and growth of tumors and on the metabolism of catecholamines and indoleamine in the medial basal hypothalamus (MBH) and the striatum (ST) of rats bearing 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumors. Catecholamines 197-211 monoamine oxidase B Rattus norvegicus 104-109 10354516-0 1999 Catecholamines participate in the induction of ornithine decarboxylase gene expression in normal and hyperplastic mouse kidney. Catecholamines 0-14 ornithine decarboxylase, structural 1 Mus musculus 47-70 10465692-4 1999 The hyperlocomotor effect of activating 5-HT1A sites also tended to decrease possibly as a result of a dependence of this response on the known depletion of catecholamines by reserpine. Catecholamines 157-171 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-46 10418335-5 1999 In this condition, tyrosine hydroxylase, the rate-limiting enzyme of catecholamine biosynthesis, was also inhibited by the treatment of higenamine in PC12 cells (21.9% inhibition at 20 microM). Catecholamines 69-82 tyrosine hydroxylase Rattus norvegicus 19-39 10354516-2 1999 Catecholamine depletion, evoked by reserpine, strongly impaired antifolate-induced ODC expression; the enzyme activity was almost completely abolished while the mRNA level decreased by 60%. Catecholamines 0-13 ornithine decarboxylase, structural 1 Mus musculus 83-86 10354516-3 1999 Moreover, under conditions of a depleted catecholamine pool, kidney enlargement was significantly reduced confirming our earlier reports on the indispensability of ODC induction for renal hyperplasia (M. Manteuffel-Cymborowska et al. Catecholamines 41-54 ornithine decarboxylase, structural 1 Mus musculus 164-167 10354516-7 1999 In normal mouse kidney catecholamines appeared to be inducers of ODC expression. Catecholamines 23-37 ornithine decarboxylase, structural 1 Mus musculus 65-68 10354516-8 1999 Use of selective agonists of catecholamine receptors demonstrated the importance of dopamine D2 receptors, and to a lower extent beta adrenoreceptors, in the catecholamine mediation of induction of ODC activity and of ODC mRNA levels. Catecholamines 29-42 ornithine decarboxylase, structural 1 Mus musculus 198-201 10354516-8 1999 Use of selective agonists of catecholamine receptors demonstrated the importance of dopamine D2 receptors, and to a lower extent beta adrenoreceptors, in the catecholamine mediation of induction of ODC activity and of ODC mRNA levels. Catecholamines 29-42 ornithine decarboxylase, structural 1 Mus musculus 218-221 10354516-9 1999 These increases were not abolished by an antiandrogen, casodex, suggesting that catecholamine control of ODC expression is an androgen receptor-independent process. Catecholamines 80-93 ornithine decarboxylase, structural 1 Mus musculus 105-108 10354516-9 1999 These increases were not abolished by an antiandrogen, casodex, suggesting that catecholamine control of ODC expression is an androgen receptor-independent process. Catecholamines 80-93 androgen receptor Mus musculus 126-143 10354516-10 1999 The results obtained point to the critical role of renal catecholamines; these biogenic amines are not only involved in the regulation of ODC expression in normal kidney but are also required for the induction of ODC in hyperplastic kidney evoked by antifolate and, as shown recently (M. Manteuffel-Cymborowska et al., Biochim. Catecholamines 57-71 ornithine decarboxylase, structural 1 Mus musculus 138-141 10354516-10 1999 The results obtained point to the critical role of renal catecholamines; these biogenic amines are not only involved in the regulation of ODC expression in normal kidney but are also required for the induction of ODC in hyperplastic kidney evoked by antifolate and, as shown recently (M. Manteuffel-Cymborowska et al., Biochim. Catecholamines 57-71 ornithine decarboxylase, structural 1 Mus musculus 213-216 10229653-9 1999 Glucocorticoids, glucagon and catecholamines cause an increase in PC activity or in the rate of pyruvate carboxylation in the short term. Catecholamines 30-44 pyruvate carboxylase Homo sapiens 66-68 10330041-7 1999 In contrast, catecholamine-mediated upregulation of alveolar liquid clearance was restored either by depletion of neutrophils with vinblastine, by the normalization of the concentration of reduced glutathione in the alveolar epithelial lining fluid by N-acetylcysteine, or by the inhibition of the conversion from xanthine dehydrogenase to xanthine oxidase. Catecholamines 13-26 xanthine dehydrogenase Rattus norvegicus 314-336 10421488-10 1999 This is most probably due to the massive endogenous catecholamine release leading to PLA2 activation. Catecholamines 52-65 phospholipase A2, major isoenzyme Sus scrofa 85-89 10337911-4 1999 Examination of the effect of catecholamines on liver injury showed that the beta2-adrenergic agonist salbutamol prevented, whereas chemical sympathectomy by 6-hydroxydopamine, deteriorated the disease. Catecholamines 29-43 hemoglobin, beta adult minor chain Mus musculus 76-81 10334809-4 1999 PAMP, but not PAMP(12-20), counteracted, in a concentration dependent manner, both aldosterone response of zona glomerulosa cells and catecholamine response of adrenal medulla cells to BAYK-8644, the selective agonist of voltage-activated Ca2+ channels, as well as to K+ and angiotensin II. Catecholamines 134-147 adrenomedullin Homo sapiens 0-4 10212311-0 1999 Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. Catecholamines 0-13 tyrosinase Mus musculus 39-49 10217296-1 1999 Tyrosine hydroxylase (TH), which converts L-tyrosine to L-DOPA, is a rate-limiting enzyme in the biosynthesis of catecholamines; its activity is regulated by feedback inhibition by catecholamine products including dopamine. Catecholamines 113-127 tyrosine hydroxylase Homo sapiens 0-20 10217296-1 1999 Tyrosine hydroxylase (TH), which converts L-tyrosine to L-DOPA, is a rate-limiting enzyme in the biosynthesis of catecholamines; its activity is regulated by feedback inhibition by catecholamine products including dopamine. Catecholamines 113-126 tyrosine hydroxylase Homo sapiens 0-20 10212311-1 1999 Catecholamine neurotransmitters are synthesized by hydroxylation of tyrosine to L-dihydroxyphenylalanine (L-Dopa) by tyrosine hydroxylase (TH). Catecholamines 0-13 tyrosine hydroxylase Mus musculus 117-137 10212311-1 1999 Catecholamine neurotransmitters are synthesized by hydroxylation of tyrosine to L-dihydroxyphenylalanine (L-Dopa) by tyrosine hydroxylase (TH). Catecholamines 0-13 tyrosine hydroxylase Mus musculus 139-141 10212311-2 1999 The elimination of TH in both pigmented and albino mice described here, like pigmented TH-null mice reported previously (Kobayashi et al., 1995; Zhou et al., 1995), demonstrates the unequivocal requirement for catecholamines during embryonic development. Catecholamines 210-224 tyrosine hydroxylase Mus musculus 19-21 10212311-3 1999 Although the lack of TH is fatal, TH-null embryos can be rescued by administration of catecholamine precursors to pregnant dams. Catecholamines 86-99 tyrosine hydroxylase Mus musculus 34-36 10212311-9 1999 In contrast to the pigmented TH-null mice, catecholamine histofluorescence is undetectable in postnatal albino mutants, and the catecholamine content of TH-null pups lacking tyrosinase is 18% or less than that of TH-null mice with tyrosinase. Catecholamines 128-141 tyrosine hydroxylase Mus musculus 153-155 10212311-9 1999 In contrast to the pigmented TH-null mice, catecholamine histofluorescence is undetectable in postnatal albino mutants, and the catecholamine content of TH-null pups lacking tyrosinase is 18% or less than that of TH-null mice with tyrosinase. Catecholamines 128-141 tyrosine hydroxylase Mus musculus 153-155 10212311-10 1999 Thus, these extraordinary circumstances reveal that tyrosinase serves as an alternative pathway to supply catecholamines. Catecholamines 106-120 tyrosinase Mus musculus 52-62 10337850-0 1999 Lack of leptin suppression in response to hypersecretion of catecholamines in pheochromocytoma patients. Catecholamines 60-74 leptin Homo sapiens 8-14 10334809-6 1999 Collectively, these findings suggest (1) that PAMP inhibits Ca2+-dependent, agonist-stimulated aldosterone and catecholamine secretion, acting via specific receptors and through a mechanism involving the impairment of Ca2+ influx; and (2) that PAMP(12-20) acts as a weak antagonist of PAMP receptors, thereby suggesting that both C- and N-terminal sequences of the PAMP molecule are required for this peptide to exert its antisecretagogue action on the human adrenal gland. Catecholamines 111-124 adrenomedullin Homo sapiens 46-50 10337850-2 1999 From several previous studies, catecholamines have been suggested to exert an inhibitory influence on leptin production in animals. Catecholamines 31-45 leptin Homo sapiens 102-108 10337850-3 1999 In the present study, we analyzed leptin levels in relation to catecholamine hypersecretion in 27 human pheochromocytoma patients. Catecholamines 63-76 leptin Homo sapiens 34-40 10212248-1 1999 The beta1-adrenergic receptor (beta1AR) is a key cell surface signaling protein expressed in the heart and other organs that mediates the actions of catecholamines of the sympathetic nervous system. Catecholamines 149-163 adrenoceptor beta 1 Homo sapiens 4-29 10361444-1 1999 Angiotensin II (AII), the effector octapeptide of the renin-angiotensin system, exerts a multitude of actions, including vascular contraction, aldosterone secretion, catecholamine release, glycogenolysis, and decreased renal filtration. Catecholamines 166-179 angiotensinogen Homo sapiens 0-14 10361444-1 1999 Angiotensin II (AII), the effector octapeptide of the renin-angiotensin system, exerts a multitude of actions, including vascular contraction, aldosterone secretion, catecholamine release, glycogenolysis, and decreased renal filtration. Catecholamines 166-179 angiotensinogen Homo sapiens 16-19 10337850-8 1999 This lack of effect may be attributable to the development of tolerance of adipose tissue leptin production to catecholamines. Catecholamines 111-125 leptin Homo sapiens 90-96 10212248-1 1999 The beta1-adrenergic receptor (beta1AR) is a key cell surface signaling protein expressed in the heart and other organs that mediates the actions of catecholamines of the sympathetic nervous system. Catecholamines 149-163 adrenoceptor beta 1 Homo sapiens 31-38 10340468-0 1999 Regulation of basal expression of catecholamine-synthesizing enzyme genes by PACAP. Catecholamines 34-47 adenylate cyclase activating polypeptide 1 Bos taurus 77-82 10336172-3 1999 The present results suggest that ATP7B plays key roles in neurotransmissions of catecholamine pathway and preventing brain tissues from injury by superoxide radicals to regulate the cellular Cu concentration and/or activities of cuproenzymes related to neurotransmissions and a free radical metabolism. Catecholamines 80-93 ATPase copper transporting beta Rattus norvegicus 33-38 10340468-1 1999 We have previously reported that the cAMP/protein kinase A (PKA) pathway is important in the gene regulation of both induction and basal expressions of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 156-169 dopamine beta-hydroxylase Bos taurus 221-246 10336176-5 1999 We also conducted immunohistochemistry of the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), in sections from perfusion-fixed male rats and showed that TH is present in neuronal perikarya and processes in the anteroventral periventricular region of the mPOA, while DBH was only seen in fibers and terminals. Catecholamines 46-59 tyrosine hydroxylase Rattus norvegicus 82-102 10336176-5 1999 We also conducted immunohistochemistry of the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), in sections from perfusion-fixed male rats and showed that TH is present in neuronal perikarya and processes in the anteroventral periventricular region of the mPOA, while DBH was only seen in fibers and terminals. Catecholamines 46-59 tyrosine hydroxylase Rattus norvegicus 104-106 10340468-1 1999 We have previously reported that the cAMP/protein kinase A (PKA) pathway is important in the gene regulation of both induction and basal expressions of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Catecholamines 156-169 dopamine beta-hydroxylase Bos taurus 248-251 10336176-5 1999 We also conducted immunohistochemistry of the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), in sections from perfusion-fixed male rats and showed that TH is present in neuronal perikarya and processes in the anteroventral periventricular region of the mPOA, while DBH was only seen in fibers and terminals. Catecholamines 46-59 dopamine beta-hydroxylase Rattus norvegicus 139-142 10340468-7 1999 Taken together, the data suggests that PACAP is involved in the regulation of maintenance of the catecholamine synthesizing enzymes TH and DBH by utilizing the cAMP/PKA pathway. Catecholamines 97-110 adenylate cyclase activating polypeptide 1 Bos taurus 39-44 10340468-7 1999 Taken together, the data suggests that PACAP is involved in the regulation of maintenance of the catecholamine synthesizing enzymes TH and DBH by utilizing the cAMP/PKA pathway. Catecholamines 97-110 dopamine beta-hydroxylase Bos taurus 139-142 10466945-0 1999 Myosin light chain kinase inhibitors and calmodulin antagonist inhibit Ca(2+)- and ATP-dependent catecholamine secretion from bovine adrenal chromaffin cells. Catecholamines 97-110 myosin light chain kinase, smooth muscle Bos taurus 0-25 10216190-3 1999 Immunoelectron microscopy revealed synaptic contacts of tyrosine hydroxylase- and NPY-immunoreactive axon terminals onto POMe neurons retrogradely labeled from the VLM catecholamine area, suggesting the existence of bidirectional connections between these two regions. Catecholamines 168-181 neuropeptide Y Rattus norvegicus 82-85 10198393-0 1999 Effects of adrenomedullin and PAMP on adrenal catecholamine release in dogs. Catecholamines 46-59 adrenomedullin Canis lupus familiaris 11-25 10232719-7 1999 Plasma concentrations of cortisol and catecholamines increased after hysterectomy (cortisol from 6 +/- 2 to 31 +/- 7 microg x dl(-1), epinephrine from 25 +/- 14 to 205 +/- 132 pg x ml(-1), norepinephrine from 182 +/- 82 to 377 +/- 132 pg x ml(-1), P < 0.05), whereas plasma lactate, insulin and glucagon concentrations remained unchanged. Catecholamines 38-52 insulin Homo sapiens 286-293 10435003-14 1999 CONCLUSIONS: I(f) expressed in SHR hypertrophied ventricular myocytes is modulated by catecholamines mainly through the stimulation of the beta 1-AR subtype. Catecholamines 86-100 adrenoceptor beta 1 Homo sapiens 139-148 10466945-0 1999 Myosin light chain kinase inhibitors and calmodulin antagonist inhibit Ca(2+)- and ATP-dependent catecholamine secretion from bovine adrenal chromaffin cells. Catecholamines 97-110 calmodulin Bos taurus 41-51 10194528-1 1999 Previous studies, by this group and others, have shown that vasoactive intestinal peptide (VIP) stimulates aldosterone secretion, and that the actions of VIP on aldosterone secretion by the rat adrenal cortex are blocked by beta adrenergic antagonists, suggesting that VIP may act by the local release of catecholamines. Catecholamines 305-319 vasoactive intestinal peptide Rattus norvegicus 60-89 10235638-1 1999 Chromogranin A (CgA), a secretory protein, is co-released with catecholamines from storage vesicles. Catecholamines 63-77 chromogranin A Homo sapiens 0-14 10194528-1 1999 Previous studies, by this group and others, have shown that vasoactive intestinal peptide (VIP) stimulates aldosterone secretion, and that the actions of VIP on aldosterone secretion by the rat adrenal cortex are blocked by beta adrenergic antagonists, suggesting that VIP may act by the local release of catecholamines. Catecholamines 305-319 vasoactive intestinal peptide Rattus norvegicus 91-94 10194528-1 1999 Previous studies, by this group and others, have shown that vasoactive intestinal peptide (VIP) stimulates aldosterone secretion, and that the actions of VIP on aldosterone secretion by the rat adrenal cortex are blocked by beta adrenergic antagonists, suggesting that VIP may act by the local release of catecholamines. Catecholamines 305-319 vasoactive intestinal peptide Rattus norvegicus 154-157 10194528-1 1999 Previous studies, by this group and others, have shown that vasoactive intestinal peptide (VIP) stimulates aldosterone secretion, and that the actions of VIP on aldosterone secretion by the rat adrenal cortex are blocked by beta adrenergic antagonists, suggesting that VIP may act by the local release of catecholamines. Catecholamines 305-319 vasoactive intestinal peptide Rattus norvegicus 154-157 10194528-2 1999 The present studies were designed to test this hypothesis further, by measuring catecholamine release by adrenal capsular tissue in response to VIP stimulation. Catecholamines 80-93 vasoactive intestinal peptide Rattus norvegicus 144-147 10194528-11 1999 In the low sodium group VIP was found to increase catecholamine release to the same extent as in the control group, however, in contrast to the control group, the adrenal response to VIP was not altered by adrenergic antagonists in the low sodium group. Catecholamines 50-63 vasoactive intestinal peptide Rattus norvegicus 24-27 10194528-12 1999 These data provide strong support for the hypothesis that VIP acts by the local release of catecholamines in adrenal zona glomerulosa tissue in normal animals. Catecholamines 91-105 vasoactive intestinal peptide Rattus norvegicus 58-61 10096940-1 1999 BACKGROUND: The cellular content of cAMP generated by activation of adenylylcyclase (AC) through the beta-adrenergic receptor (betaAR) is a key determinant of a cell"s response to catecholamine stimulation. Catecholamines 180-193 adrenergic receptor, beta 1 Mus musculus 101-125 10096940-1 1999 BACKGROUND: The cellular content of cAMP generated by activation of adenylylcyclase (AC) through the beta-adrenergic receptor (betaAR) is a key determinant of a cell"s response to catecholamine stimulation. Catecholamines 180-193 adrenergic receptor, beta 1 Mus musculus 127-133 10235638-1 1999 Chromogranin A (CgA), a secretory protein, is co-released with catecholamines from storage vesicles. Catecholamines 63-77 chromogranin A Homo sapiens 16-19 10217540-17 1999 These results indicate that the effects of thyroid hormones on the responsiveness of BAT to catecholamines involves both receptor and post-receptor mechanisms, they also suggest that interaction between amiodarone and thyroid hormones is highly tissue-specific and depends on the beta-AR subtype. Catecholamines 92-106 adrenoceptor beta 3 Rattus norvegicus 280-287 10064798-3 1999 Adrenaline levels were undetectable in the PCG but to test the hypothesis that PNMT is active in SIF cells, catecholamines were measured in ganglia of rats pretreated with pargyline, an inhibitor of the monoamine oxidase, the major enzyme involved in the catecholamine degradation. Catecholamines 108-122 phenylethanolamine-N-methyltransferase Rattus norvegicus 79-83 10064798-3 1999 Adrenaline levels were undetectable in the PCG but to test the hypothesis that PNMT is active in SIF cells, catecholamines were measured in ganglia of rats pretreated with pargyline, an inhibitor of the monoamine oxidase, the major enzyme involved in the catecholamine degradation. Catecholamines 108-121 phenylethanolamine-N-methyltransferase Rattus norvegicus 79-83 10221345-3 1999 In the present study, we used this mouse model to examine the degree to which ET-1 contributes to the responses of blood pressure and catecholamine metabolism to high salt loading. Catecholamines 134-147 endothelin 1 Mus musculus 78-82 10347796-14 1999 Our data also suggest that the increased sympathetic discharge and the elevated plasma concentration of catecholamines may contribute to the upregulation of ACE expression in the heart after myocardial infarction and heart failure. Catecholamines 104-118 angiotensin I converting enzyme Rattus norvegicus 157-160 9950870-1 1999 Previous investigators have demonstrated that the tumor necrosis factor-alpha (TNF-alpha) response to endotoxin is inhibited by exogenous corticosterone or catecholamines both in vitro and in vivo, whereas others have reported that surgical and nonsurgical stress increase the endogenous concentrations of these stress-induced hormones. Catecholamines 156-170 tumor necrosis factor Rattus norvegicus 50-77 10028057-8 1999 Collectively, our findings suggest that, when the integrity of adrenal tissue is preserved, a two-fold mechanism underlies the aldosterone secretagogue action of ET-1 in the rat: i) a direct mechanism mediated by ETB receptors located on ZG cells; and ii) an indirect mechanism involving the ETA and ETB receptor-mediated local release of catecholamines, which in turn stimulate ZG cells in a paracrine manner. Catecholamines 339-353 endothelin receptor type B Rattus norvegicus 213-216 10229127-1 1999 Beta2- and alpha2-adrenergic receptors (AR) are thought to be the main AR subtypes to exert the effects of catecholamines on the immune system. Catecholamines 107-121 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 0-5 9920865-0 1999 Enzyme activity of macrophage migration inhibitory factor toward oxidized catecholamines. Catecholamines 74-88 macrophage migration inhibitory factor Homo sapiens 19-57 9920865-3 1999 Here we show that MIF is able to catalyze the conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin. Catecholamines 164-178 macrophage migration inhibitory factor Homo sapiens 18-21 9920865-4 1999 This raises the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have a protective role in neural tissues, which as in Parkinson"s disease, may be subject to catecholamine-related cell death. Catecholamines 82-95 macrophage migration inhibitory factor Homo sapiens 33-36 9920865-4 1999 This raises the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have a protective role in neural tissues, which as in Parkinson"s disease, may be subject to catecholamine-related cell death. Catecholamines 218-231 macrophage migration inhibitory factor Homo sapiens 33-36 9950870-1 1999 Previous investigators have demonstrated that the tumor necrosis factor-alpha (TNF-alpha) response to endotoxin is inhibited by exogenous corticosterone or catecholamines both in vitro and in vivo, whereas others have reported that surgical and nonsurgical stress increase the endogenous concentrations of these stress-induced hormones. Catecholamines 156-170 tumor necrosis factor Rattus norvegicus 79-88 9927320-18 1999 The synergistic induction by cytokines and catecholamines of glial cell-derived IL-6 may subsequently affect inflammatory, neurodegenerative or neurotropic processes in the CNS. Catecholamines 43-57 interleukin 6 Rattus norvegicus 80-84 10079965-2 1999 Catecholamine (dopamine, norepinephrine, and epinephrine) biosynthesis is regulated by tyrosine hydroxylase (TH). Catecholamines 0-13 tyrosine hydroxylase Homo sapiens 87-107 10079965-2 1999 Catecholamine (dopamine, norepinephrine, and epinephrine) biosynthesis is regulated by tyrosine hydroxylase (TH). Catecholamines 0-13 tyrosine hydroxylase Homo sapiens 109-111 10079965-4 1999 Thus, GCH activity indirectly regulates TH activity and catecholamine levels. Catecholamines 56-69 GTP cyclohydrolase 1 Homo sapiens 6-9 9927289-0 1999 Parathyroid hormone-related protein markedly potentiates depolarization-induced catecholamine release in PC12 cells via L-type voltage-sensitive Ca2+ channels. Catecholamines 80-93 parathyroid hormone-like hormone Rattus norvegicus 0-35 9927289-9 1999 The PTHrP-augmented catecholamine secretion depends entirely upon L-VSCC Ca2+ influx and rapidly inactivates. Catecholamines 20-33 parathyroid hormone-like hormone Rattus norvegicus 4-9 9927289-12 1999 In the normal adrenal medulla that expresses both PTHrP and its receptor, PTHrP may act in an autocrine/paracrine fashion to modify catecholamine secretion. Catecholamines 132-145 parathyroid hormone-like hormone Rattus norvegicus 50-55 9927289-12 1999 In the normal adrenal medulla that expresses both PTHrP and its receptor, PTHrP may act in an autocrine/paracrine fashion to modify catecholamine secretion. Catecholamines 132-145 parathyroid hormone-like hormone Rattus norvegicus 74-79 10068849-2 1999 Proadrenomedullin N-terminal 20 peptide (PAMP) processed from an AM precursor is also a novel hypotensive peptide which inhibits catecholamine secretion from sympathetic nerve endings. Catecholamines 129-142 adrenomedullin Homo sapiens 0-39 10068849-2 1999 Proadrenomedullin N-terminal 20 peptide (PAMP) processed from an AM precursor is also a novel hypotensive peptide which inhibits catecholamine secretion from sympathetic nerve endings. Catecholamines 129-142 adrenomedullin Homo sapiens 41-45 10075051-8 1999 CONCLUSIONS: Our data suggest that TNF-alpha induces a defect in beta-adrenergic signal transduction and catecholamine-stimulated contractility in neonatal rat cardiac myocytes. Catecholamines 105-118 tumor necrosis factor Rattus norvegicus 35-44 9927320-0 1999 Interleukin-1beta and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro: a potential role for lysophosphatidylcholine. Catecholamines 22-36 interleukin 6 Rattus norvegicus 63-76 9927320-3 1999 We have examined the regulation of IL-6 release from glial cells by cytokines and catecholamines. Catecholamines 82-96 interleukin 6 Rattus norvegicus 35-39 9927320-9 1999 The combination of 1.0 to 100 microM of each catecholamine with IL-1beta resulted in the synergistic stimulation of IL-6 release. Catecholamines 45-58 interleukin 6 Rattus norvegicus 116-120 10051759-10 1999 Taken together, these data suggest that: (i) amphetamine and cocaine interact with the DA transporter to produce distinct actions which under certain circumstances can compete with each other; (ii) the amphetamine-induced release of DA from the somata and dendrites of the dopaminergic cells is, at least in part, related to the reverse operation of the DA transporter and is not dependent on the integrity of the vesicular content of the catecholamine. Catecholamines 439-452 solute carrier family 6 member 3 Rattus norvegicus 87-101 10219960-2 1999 1.1.2.8, PNMT), the final enzyme in the cascade of catecholamine synthesis, is differentially regulated in adrenergic neurons in the brain and in adrenal chromaffin cells. Catecholamines 51-64 phenylethanolamine-N-methyltransferase Rattus norvegicus 9-13 9922344-6 1999 RESULTS: Both early and late left ventricular ejection fraction (LVEF) were most closely related to plasma BNP (r = -0.60, n = 220, p < 0.001; and r = -0.53, n = 192, p < 0.001, respectively), followed by ANF, N-ANF, cGMP, and the plasma catecholamines. Catecholamines 244-258 natriuretic peptide B Homo sapiens 107-110 9922344-13 1999 CONCLUSIONS: Plasma BNP measured within 1-4 days of acute myocardial infarction is a powerful independent predictor of left ventricular function, heart failure, or death over the subsequent 14 months, and superior to ANF, N-ANF, cGMP, and plasma catecholamines. Catecholamines 246-260 natriuretic peptide B Homo sapiens 20-23 10082242-5 1999 The results clearly show that both plasma and platelet concentrations of catecholamines are significantly affected by CCK4. Catecholamines 73-87 protein tyrosine kinase 7 (inactive) Homo sapiens 118-122 9915830-3 1999 We investigated the effects of a novel chromogranin A catecholamine release-inhibitory fragment, catestatin (chromogranin A344-364), on agonist-induced desensitization of catecholamine release from pheochromocytoma cells. Catecholamines 54-67 chromogranin A Homo sapiens 97-107 9915830-3 1999 We investigated the effects of a novel chromogranin A catecholamine release-inhibitory fragment, catestatin (chromogranin A344-364), on agonist-induced desensitization of catecholamine release from pheochromocytoma cells. Catecholamines 171-184 chromogranin A Homo sapiens 97-107 9915830-4 1999 In a dose-dependent fashion, the nicotinic antagonist catestatin blocked agonist desensitization of both catecholamine release (IC50 approximately 0.24 microM) and 22Na+ uptake (IC50 approximately 0.31 microM), the initial step in nicotinic cationic signal transduction; both secretion inhibition and blockade of desensitization were noncompetitive with agonist. Catecholamines 105-118 chromogranin A Homo sapiens 54-64 9915830-11 1999 We conclude that catestatin is a highly potent, dose-dependent, noncompetitive, noncooperative, specific inhibitor of nicotinic desensitization, an effect which may have implications for control of catecholamine release. Catecholamines 198-211 chromogranin A Homo sapiens 17-27 9988104-10 1999 These results suggest that the vasodilator effects of PACAP-27 are due to actions in the microcirculation rather than to the release of adrenal catecholamines and that this vasodilation may not involve the release of endothelium-derived NO. Catecholamines 144-158 adenylate cyclase activating polypeptide 1 Rattus norvegicus 54-59 9878736-10 1999 Taken together, these findings indicate that IL-1beta impairs lung clearance of MADB106 tumor cells via the actions of adrenal catecholamines, most likely epinephrine, acting at beta-adrenergic receptors in the periphery. Catecholamines 127-141 interleukin 1 beta Rattus norvegicus 45-53 12114769-8 1999 These results indicate that Cu,Zn-SOD and Mu-SOD may play different roles as a scavenger or antioxidants in normal human adrenal glands, i.e., Cu,Zn-SOD as a scavenger of toxic superoxide radicals generated during steroidogenesis and Mn-SOD during catecholamine production. Catecholamines 248-261 superoxide dismutase 1 Homo sapiens 34-37 12114769-8 1999 These results indicate that Cu,Zn-SOD and Mu-SOD may play different roles as a scavenger or antioxidants in normal human adrenal glands, i.e., Cu,Zn-SOD as a scavenger of toxic superoxide radicals generated during steroidogenesis and Mn-SOD during catecholamine production. Catecholamines 248-261 superoxide dismutase 1 Homo sapiens 45-48 12114769-8 1999 These results indicate that Cu,Zn-SOD and Mu-SOD may play different roles as a scavenger or antioxidants in normal human adrenal glands, i.e., Cu,Zn-SOD as a scavenger of toxic superoxide radicals generated during steroidogenesis and Mn-SOD during catecholamine production. Catecholamines 248-261 superoxide dismutase 1 Homo sapiens 45-48 10193856-3 1999 This is due to multiple alterations in catecholamine signal transduction, involving decreased expression and function of beta2-adrenoceptors, increased function of alpha2-adrenoceptors and decreased ability of cyclic monophosphate (AMP) to stimulate hormone sensitive lipase. Catecholamines 39-52 lipase E, hormone sensitive type Homo sapiens 250-274 10408151-3 1999 In this article, the role of bradykinin on catecholamine biosynthesis, secretion and Ca2+ movement in adrenal chromaffin cells as a model for catecholamine-containing neurons are examined. Catecholamines 43-56 kininogen 1 Homo sapiens 29-39 10408151-12 1999 It is interesting that bradykinin, which stimulates the biosynthesis and secretion of catecholamine in adrenal chromaffin cells, plays a role in the termination of calcium-signal transduction through the stimulation of Ca2+ efflux from the cells. Catecholamines 86-99 kininogen 1 Homo sapiens 23-33 9891025-1 1999 The stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, is regulated by oxygen tension in the pheochromocytoma-derived PC12 cell line. Catecholamines 81-94 tyrosine hydroxylase Rattus norvegicus 26-46 9891025-1 1999 The stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, is regulated by oxygen tension in the pheochromocytoma-derived PC12 cell line. Catecholamines 81-94 tyrosine hydroxylase Rattus norvegicus 48-50 10210165-1 1999 Tyrosine hydroxylase (TH) activity, the rate-limiting step in the synthesis of catecholamines, was quantified in the preoptic area-hypothalamus of adult male Japanese quail by a new assay measuring the tritiated water production from 3,5-[3H]-L-tyrosine. Catecholamines 79-93 tyrosine 3-monooxygenase Coturnix japonica 0-20 10210165-1 1999 Tyrosine hydroxylase (TH) activity, the rate-limiting step in the synthesis of catecholamines, was quantified in the preoptic area-hypothalamus of adult male Japanese quail by a new assay measuring the tritiated water production from 3,5-[3H]-L-tyrosine. Catecholamines 79-93 tyrosine 3-monooxygenase Coturnix japonica 22-24 10082242-8 1999 In summary, we have demonstrated that, in healthy subjects, CCK4 increases peripheral concentrations of catecholamines in both plasma and platelets, with the most consistent changes occurring in platelet NE and plasma EPI concentrations. Catecholamines 104-118 protein tyrosine kinase 7 (inactive) Homo sapiens 60-64 10210276-9 1999 The aberrant gene expression of ANP and CDV-1 found in JVS mice seems to be independent of catecholamine metabolism, and mediated primarily by the systemic carnitine deficiency. Catecholamines 91-104 natriuretic peptide type A Mus musculus 32-35 10568256-1 1999 Mutations in the Third chromosome resistance (Tcr; 3-39.6) gene confer dominant resistance to alpha-methyl dopa and suggest the gene is involved in catecholamine metabolism. Catecholamines 148-161 Tcr Drosophila melanogaster 17-44 10568256-1 1999 Mutations in the Third chromosome resistance (Tcr; 3-39.6) gene confer dominant resistance to alpha-methyl dopa and suggest the gene is involved in catecholamine metabolism. Catecholamines 148-161 Tcr Drosophila melanogaster 46-49 10568256-2 1999 Evidence for involvement in catecholamine metabolism comes from the three phenotypes associated with the mutant Tcr chromosomes--dominant resistance, dominant rescue of partially complementing l(2)amd alleles, and recessive lethal phenotypes. Catecholamines 28-41 Tcr Drosophila melanogaster 112-115 10220141-1 1999 Mutations in the 6-pyruvoyltetrahydropterin synthase (PTPS) gene result in persistent hyperphenylalaninemia and severe catecholamine and serotonin deficiencies. Catecholamines 119-132 6-pyruvoyltetrahydropterin synthase Homo sapiens 17-52 10220141-1 1999 Mutations in the 6-pyruvoyltetrahydropterin synthase (PTPS) gene result in persistent hyperphenylalaninemia and severe catecholamine and serotonin deficiencies. Catecholamines 119-132 6-pyruvoyltetrahydropterin synthase Homo sapiens 54-58 10651101-8 1999 The basal concentration and stress induced changes of NE, DA, MHPG, DOPAC in the fluid of the III-rd brain ventricle (V-III) reflect a dynamic relationship between extracellular levels of catecholamines and their metabolites in the hypothalamus and cerebral fluid. Catecholamines 188-202 cytochrome c oxidase subunit 8A Homo sapiens 118-123 9931092-7 1999 These results suggest that CNP attenuates evoked catecholamine efflux from PC12 cells by a mechanism requiring Goalpha but independent of GC activation. Catecholamines 49-62 natriuretic peptide C Rattus norvegicus 27-30 10907721-6 1999 In these regions, almost all the cells also show immunoreactivity for aromatic L-amino acid decarboxylase (AADC), the second step enzyme for catecholamine synthesis, indicating that these neurons are catecholaminergic. Catecholamines 141-154 dopa decarboxylase Homo sapiens 70-105 10907721-6 1999 In these regions, almost all the cells also show immunoreactivity for aromatic L-amino acid decarboxylase (AADC), the second step enzyme for catecholamine synthesis, indicating that these neurons are catecholaminergic. Catecholamines 141-154 dopa decarboxylase Homo sapiens 107-111 10426531-1 1999 Widespread brain-derived neurotrophic factor messenger RNA expression has been detected in the region of catecholamine groups of the rat lower brainstem, while few brain-derived neurotrophic factor-immunoreactive cells were found in this area. Catecholamines 105-118 brain-derived neurotrophic factor Rattus norvegicus 11-44 10374901-1 1999 The high level transection of the spinal cord (C-7) provokes a sustained increase of rat liver catecholamines: biphasic increase in norepinephrine level 1 hour and 24 hour after the operation and 7-fold increase of dopamine content 4 hour after the chordotomy. Catecholamines 95-109 complement C7 Rattus norvegicus 47-50 10408599-10 1999 These data demonstrate that there is a double dissociation of the catecholamine modulation of long-term potentiation between CA1 and the dentate gyrus, suggesting that long-term potentiation in these brain areas may be differentially consolidated according to the animal"s behavioural state. Catecholamines 66-79 carbonic anhydrase 1 Homo sapiens 125-128 9973233-5 1999 Stomach also showed consistent expression of TH mRNA before, but not after 6-OHDA, suggesting that catecholamine synthesizing cells in gastric tissue are sensitive to the toxic effects of 6-OHDA. Catecholamines 99-112 tyrosine hydroxylase Rattus norvegicus 45-47 10391454-0 1999 Ultrastructural evidence that substance P neurons form synapses with noradrenergic neurons in the A7 catecholamine cell group that modulate nociception. Catecholamines 101-114 tachykinin precursor 1 Homo sapiens 30-41 9830057-4 1998 In the present work, the counter-regulatory action of insulin on catecholamine action is shown to stimulate enhanced sequestration of beta2-adrenergic receptors in either DDT1MF-2 smooth muscle cells or Chinese hamster ovary cells stably expressing beta2-adrenergic receptors. Catecholamines 65-78 insulin Mesocricetus auratus 54-61 10465447-5 1999 Herein, using in situ hybridization histochemistry, we show that Nurr1 is expressed only in subset of catecholamine producing neurons (A2 partly, A8-A10 and A11 catecholaminergic cell groups), and is excluded from the norepinephrine producing neurons (A1, A2, A5-A6 catecholaminergic cell groups). Catecholamines 102-115 nuclear receptor subfamily 4 group A member 2 Homo sapiens 65-70 10579570-7 1999 The inhibition of plasma catecholamine and locus coeruleus tyrosine hydroxylase messenger RNA responses to stress by central corticotropin-releasing hormone receptor blockade supports the notion that central corticotropin-releasing hormone regulates sympathoadrenal responses during stress. Catecholamines 25-38 corticotropin releasing hormone Rattus norvegicus 125-156 10579570-7 1999 The inhibition of plasma catecholamine and locus coeruleus tyrosine hydroxylase messenger RNA responses to stress by central corticotropin-releasing hormone receptor blockade supports the notion that central corticotropin-releasing hormone regulates sympathoadrenal responses during stress. Catecholamines 25-38 corticotropin releasing hormone Rattus norvegicus 208-239 10613502-9 1999 Moreover, when double-label immunocytochemistry was used to identify cFos- and catecholamine-positive neurons in the brainstem, it was found that catecholamine-positive neurons in the ventrolateral medulla and locus coeruleus showed a significant increase in cFos expression in response to suckling compared with non-resuckled and pup-exposure groups. Catecholamines 146-159 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 69-73 10613502-9 1999 Moreover, when double-label immunocytochemistry was used to identify cFos- and catecholamine-positive neurons in the brainstem, it was found that catecholamine-positive neurons in the ventrolateral medulla and locus coeruleus showed a significant increase in cFos expression in response to suckling compared with non-resuckled and pup-exposure groups. Catecholamines 146-159 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 259-263 10613507-4 1999 We found that bilateral central amygdala lesions significantly reduced interleukin-1beta-induced c-fos expression in cells of the ventromedial and ventrolateral subdivisions of the bed nucleus of the stria terminalis and brainstem catecholamine cell groups of the nucleus tractus solitarius (A2 noradrenergic cells) and ventrolateral medulla (A1 noradrenergic and C1 adrenergic cells). Catecholamines 231-244 interleukin 1 beta Homo sapiens 71-88 10645145-3 1999 The consequence of catecholamine activation of beta 3-AR is increased mobilization of fatty acids from triglyceride stores (lipolysis) in brown and white adipose tissue as well as increased fatty acid beta-oxidation and heat-production via UCP-1 (thermogenesis) in brown adipose tissue. Catecholamines 19-32 adrenoceptor beta 3 Homo sapiens 47-56 10645145-3 1999 The consequence of catecholamine activation of beta 3-AR is increased mobilization of fatty acids from triglyceride stores (lipolysis) in brown and white adipose tissue as well as increased fatty acid beta-oxidation and heat-production via UCP-1 (thermogenesis) in brown adipose tissue. Catecholamines 19-32 uncoupling protein 1 Homo sapiens 240-245 10465451-0 1999 Hypothalamic A14 and A15 catecholamine cells provide the dopaminergic innervation to the supraoptic nucleus in rat: a combined retrograde tracer and immunohistochemical study. Catecholamines 25-38 tetraspanin 7 Rattus norvegicus 21-24 9877249-6 1998 Thus, insulin, catecholamines and anterior pituitary endocrine axes interact at multiple levels with both cytokines and leptin. Catecholamines 15-29 leptin Homo sapiens 120-126 9875353-0 1998 Differential time- and dose-related effects of haemorrhage on tyrosine hydroxylase and neuropeptide Y mRNA expression in medullary catecholamine neurons. Catecholamines 131-144 neuropeptide Y Rattus norvegicus 87-101 9875353-3 1998 A 15% haemorrhage provoked increased NPY expression in all medullary catecholamine cell groups except the A2; these changes were detected predominantly in Fos-immunoreactive neurons (Fos-ir) at later (2-4 h) time points. Catecholamines 69-82 neuropeptide Y Rattus norvegicus 37-40 9875353-7 1998 These findings indicate that haemorrhage differentially affects TH and NPY expression in medullary catecholamine cell groups that participate in the maintenance of cardiovascular homeostasis. Catecholamines 99-112 neuropeptide Y Rattus norvegicus 71-74 9826275-7 1998 Since VMAT2 serves to transport catecholamines besides serotonin, we examined the developmental expression of the plasma membrane dopamine and norepinephrine transporters but found no transient expression of these genes. Catecholamines 32-46 solute carrier family 18 member A2 Homo sapiens 6-11 9832689-14 1998 In patients exhibiting this syndrome after high-risk cardiac operations, replacement of arginine vasopressin increases blood pressure and reduces catecholamine pressor requirements. Catecholamines 146-159 arginine vasopressin Homo sapiens 97-108 10052870-2 1998 High early nerve growth factor in some vasculature of spontaneously hypertensive rats increases sympathetic innervation and catecholamine production in these vessels. Catecholamines 124-137 nerve growth factor Rattus norvegicus 11-30 9822156-1 1998 Mice lacking expression of tyrosine hydroxylase (TH), the first and rate-limiting enzyme of the catecholamine biosynthetic pathway, in dopaminergic neuronal cell types were generated by a transgenic rescue approach to clarify the role of dopamine signaling during postnatal development. Catecholamines 96-109 tyrosine hydroxylase Mus musculus 27-47 9867073-7 1998 The specific beta3 catecholamine agonist CI 316,243 inhibited the effects of dexamethasone on leptin release and leptin mRNA accumulation, as did EGF, without affecting 18S RNA content. Catecholamines 19-32 leptin Rattus norvegicus 94-100 9867073-7 1998 The specific beta3 catecholamine agonist CI 316,243 inhibited the effects of dexamethasone on leptin release and leptin mRNA accumulation, as did EGF, without affecting 18S RNA content. Catecholamines 19-32 leptin Rattus norvegicus 113-119 9822156-1 1998 Mice lacking expression of tyrosine hydroxylase (TH), the first and rate-limiting enzyme of the catecholamine biosynthetic pathway, in dopaminergic neuronal cell types were generated by a transgenic rescue approach to clarify the role of dopamine signaling during postnatal development. Catecholamines 96-109 tyrosine hydroxylase Mus musculus 49-51 9808618-0 1998 The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Catecholamines 67-80 endothelial PAS domain protein 1 Mus musculus 44-49 9863660-0 1998 Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1 alpha via a beta adrenoceptor mediated mechanism. Catecholamines 25-39 chemokine (C-C motif) ligand 3 Mus musculus 66-111 9863660-12 1998 augmented the production of this chemokine, confirming the role of a beta-adrenoceptor mediated endogenous catecholamine action in the regulation of MIP-1alpha production in vivo. Catecholamines 107-120 chemokine (C-C motif) ligand 3 Mus musculus 149-159 9863660-13 1998 Thus, based on our data we conclude that catecholamines are important endogenous regulators of MIP-1alpha expression in inflammation. Catecholamines 41-55 chemokine (C-C motif) ligand 3 Mus musculus 95-105 9808618-3 1998 In addition to the vascular endothelium, EPAS1 is expressed intensively in the organ of Zuckerkandl (OZ), the principle source of catecholamine production in mammalian embryos. Catecholamines 130-143 endothelial PAS domain protein 1 Homo sapiens 41-46 9822452-1 1998 Proadrenomedullin N-terminal 20 peptide (PAMP-[1-20]; ARLDVASEFRKKWNKWALSR-amide) is a potent hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells. Catecholamines 110-123 adrenomedullin Homo sapiens 41-45 9822452-3 1998 We tested human PAMP-[1-20] on catecholamine secretion in PC12 pheochromocytoma cells and found it to be a potent, dose-dependent (IC50 approximately 350 nmol/L) secretory inhibitor. Catecholamines 31-44 adrenomedullin Homo sapiens 16-20 9808618-6 1998 We hypothesize that EPAS1 expressed in the OZ senses hypoxia during mid-gestational development and translates this signal into an altered pattern of gene expression, leading to increases in circulating catecholamine levels and proper cardiac function. Catecholamines 203-216 endothelial PAS domain protein 1 Mus musculus 20-25 9822452-8 1998 PAMP also blocked (EC50 approximately 270 nmol/L) nicotinic cholinergic agonist desensitization of catecholamine release, as well as desensitization of nicotinic signal transduction (22Na+ uptake). Catecholamines 99-112 adrenomedullin Homo sapiens 0-4 9821851-1 1998 Type IV phosphodiesterase (PDE4) inhibitors may be useful in several diseases in which catecholamine infusions are commonly used, including asthma, sepsis, and multiple organ failure. Catecholamines 87-100 phosphodiesterase 4A Homo sapiens 27-31 9822452-10 1998 PAMP may therefore contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release. Catecholamines 107-120 adrenomedullin Homo sapiens 0-4 9918386-8 1998 In conclusion, during insulin-induced hypoglycemia, PDE 3 activation clearly counteracts the lipolytic effect of catecholamines. Catecholamines 113-127 insulin Homo sapiens 22-29 9821851-9 1998 Our data suggest that PDE4 inhibitors may be safely used in critically ill patients receiving catecholamines. Catecholamines 94-108 phosphodiesterase 4A Homo sapiens 22-26 9795163-1 1998 The actions of vasoactive intestinal polypeptide (VIP) on catecholamine secretion and changes in [Ca2+]i in single rat chromaffin cells were studied using amperometry and Indo-1. Catecholamines 58-71 vasoactive intestinal peptide Rattus norvegicus 15-48 9794415-9 1998 Catecholamine-mediated beta-adrenergic protein kinase A-dependent Thy-1 mRNA destabilization may be an example of a more general mRNA decay system regulating cellular responses to stress. Catecholamines 0-13 thymus cell antigen 1, theta Mus musculus 66-71 9794415-0 1998 Mechanism of catecholamine-mediated destabilization of messenger RNA encoding Thy-1 protein in T-lineage cells. Catecholamines 13-26 thymus cell antigen 1, theta Mus musculus 78-83 9794415-2 1998 This study analyzes effects of cAMP and catecholamines on transcriptional Thy-1 gene expression. Catecholamines 40-54 thymus cell antigen 1, theta Mus musculus 74-79 9808704-9 1998 Together, these findings 1) provide evidence in support of G-protein coupled receptor-mediated regulation of catecholamine transport, 2) reveal intracellular Ca++-sensitive, PKC-dependent and -independent pathways that serve to regulate NET expression and 3) indicate that the diminished capacity for NE transport evident after mAChR and PKC activation involves a redistribution of NET protein. Catecholamines 109-122 C-X-C motif chemokine receptor 6 Homo sapiens 59-85 9814544-1 1998 One of the significant factors that affect brain dopamine function is the activity of tyrosine hydroxylase (TH), the first and rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 151-164 tyrosine hydroxylase Homo sapiens 86-106 9814544-1 1998 One of the significant factors that affect brain dopamine function is the activity of tyrosine hydroxylase (TH), the first and rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 151-164 tyrosine hydroxylase Homo sapiens 108-110 9830685-8 1998 Preliminary observations suggest that C-18 and C-19 sex steroid hormones (17 beta-estradiol and testosterone) may have morphologic effects opposite to those of the 11-oxygenated compounds, showing a slight stimulatory influence on the formation of neurite projections, but no significant effect on catecholamine content. Catecholamines 298-311 Bardet-Biedl syndrome 9 Homo sapiens 38-42 9795163-1 1998 The actions of vasoactive intestinal polypeptide (VIP) on catecholamine secretion and changes in [Ca2+]i in single rat chromaffin cells were studied using amperometry and Indo-1. Catecholamines 58-71 vasoactive intestinal peptide Rattus norvegicus 50-53 9795163-12 1998 Thus in rat chromaffin cells, VIP acts both directly as a neurotransmitter in provoking sustained catecholamine secretion in a cAMP-independent manner, and also by enhancing ACh-induced secretion, via a cAMP-dependent action involving muscarinic receptors. Catecholamines 98-111 vasoactive intestinal peptide Rattus norvegicus 30-33 9774362-2 1998 The position of tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis renders it a candidate gene for the etiology of hypertension. Catecholamines 73-86 tyrosine hydroxylase Homo sapiens 16-36 9781735-14 1998 Among the catecholamines, dopamine is the least likely, and dobutamine the most likely, to increase pHi. Catecholamines 10-24 glucose-6-phosphate isomerase Homo sapiens 100-103 9765218-0 1998 A novel protein containing Cdc10/SWI6 motifs regulates expression of mRNA encoding catecholamine biosynthesizing enzymes. Catecholamines 83-96 septin 7 Rattus norvegicus 27-32 9765218-3 1998 Here, we provide evidence that overexpression of a novel cdc10/SWI6 motif-containing protein, V-1, elicits the coordinate up-regulation of tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and dopamine beta-hydroxylase mRNAs in the neuronal cell line PC12D, and as a result, catecholamine levels are increased. Catecholamines 284-297 septin 7 Rattus norvegicus 57-62 9765218-3 1998 Here, we provide evidence that overexpression of a novel cdc10/SWI6 motif-containing protein, V-1, elicits the coordinate up-regulation of tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and dopamine beta-hydroxylase mRNAs in the neuronal cell line PC12D, and as a result, catecholamine levels are increased. Catecholamines 284-297 dopamine beta-hydroxylase Rattus norvegicus 202-227 9809795-0 1998 Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity. Catecholamines 41-54 chromogranin A Bos taurus 23-37 9809795-1 1998 A novel fragment of chromogranin A, known as "catestatin" (bovine chromogranin A344-364), inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist, and may therefore constitute an endogenous autocrine feedback regulator of sympathoadrenal activity. Catecholamines 99-112 chromogranin A Bos taurus 20-34 9756528-1 1998 Effects of exogenous acidic fibroblast growth factor (aFGF), which is increased in the brain by food intake, on the plasma levels of catecholamines and on sympathetic efferent outflow were examined in anesthetized rats. Catecholamines 133-147 fibroblast growth factor 1 Rattus norvegicus 21-52 9756528-1 1998 Effects of exogenous acidic fibroblast growth factor (aFGF), which is increased in the brain by food intake, on the plasma levels of catecholamines and on sympathetic efferent outflow were examined in anesthetized rats. Catecholamines 133-147 fibroblast growth factor 1 Rattus norvegicus 54-58 9774362-2 1998 The position of tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis renders it a candidate gene for the etiology of hypertension. Catecholamines 73-86 tyrosine hydroxylase Homo sapiens 38-40 9774362-22 1998 A common and potentially functional variant at codon 81(Val-->Met) within exon 2 of the TH gene (which we show to be in linkage disequilibrium with TH-STR) was also typed in our YHT but did not associate with catecholamine levels and is therefore unlikely to account for our findings with D and E TH-STR. Catecholamines 212-225 tyrosine hydroxylase Homo sapiens 91-93 9774362-22 1998 A common and potentially functional variant at codon 81(Val-->Met) within exon 2 of the TH gene (which we show to be in linkage disequilibrium with TH-STR) was also typed in our YHT but did not associate with catecholamine levels and is therefore unlikely to account for our findings with D and E TH-STR. Catecholamines 212-225 tyrosine hydroxylase Homo sapiens 151-153 9774362-22 1998 A common and potentially functional variant at codon 81(Val-->Met) within exon 2 of the TH gene (which we show to be in linkage disequilibrium with TH-STR) was also typed in our YHT but did not associate with catecholamine levels and is therefore unlikely to account for our findings with D and E TH-STR. Catecholamines 212-225 tyrosine hydroxylase Homo sapiens 151-153 9817549-2 1998 Immunohistochemical studies have confirmed the presence of catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the majority of fine, varicose intramuscular nerves, about two-thirds of which also contain neuropeptide Y (NPY). Catecholamines 59-72 dopamine beta-hydroxylase Homo sapiens 124-149 9831229-14 1998 Our results point to a possible physiological role played by alpha2-adrenoceptors on insulin secretion, since their stimulation by the endogenous catecholamines could lead to inhibition of insulin release, masking any potentiated response that otherwise should have appeared from alpha1- and beta-adrenoceptor stimulation. Catecholamines 146-160 insulin Oryctolagus cuniculus 85-92 9831229-14 1998 Our results point to a possible physiological role played by alpha2-adrenoceptors on insulin secretion, since their stimulation by the endogenous catecholamines could lead to inhibition of insulin release, masking any potentiated response that otherwise should have appeared from alpha1- and beta-adrenoceptor stimulation. Catecholamines 146-160 insulin Oryctolagus cuniculus 189-196 9802399-1 1998 Our laboratory has previously used NGF-differentiated PC12 cells as a sympathetic neuronal model to investigate the effects of NPY on catecholamine synthesis and release. Catecholamines 134-147 neuropeptide Y Rattus norvegicus 127-130 9848093-4 1998 We now report that catecholamines (norepinephrine, epinephrine, and dopamine) increase the vulnerability of cultured hippocampal neurons to A beta toxicity. Catecholamines 19-33 amyloid beta precursor protein Homo sapiens 140-146 9848093-5 1998 The catecholamines were effective in potentiating A beta toxicity at concentrations of 10-200 microM, with the higher concentrations (100-200 microM) themselves inducing cell death. Catecholamines 4-18 amyloid beta precursor protein Homo sapiens 50-56 9848093-7 1998 Levels of membrane lipid peroxidation, and cytoplasmic and mitochondrial reactive oxygen species, were increased following exposure to neurons to A beta, and catecholamines exacerbated the oxidative stress. Catecholamines 158-172 amyloid beta precursor protein Homo sapiens 146-152 9848093-8 1998 Subtoxic concentrations of catecholamines exacerbated decreases in mitochondrial energy charge and transmembrane potential caused by A beta, and higher concentrations of catecholamines alone induced mitochondrial dysfunction. Catecholamines 27-41 amyloid beta precursor protein Homo sapiens 133-139 9848093-10 1998 Measurements of intracellular free Ca2+ ([Ca2+]i) showed that A beta induced a slow elevation of [Ca2+]i which was greatly enhanced in cultures cotreated with catecholamines. Catecholamines 159-173 amyloid beta precursor protein Homo sapiens 62-68 9848093-11 1998 Collectively, these data indicate a role for catecholamines in exacerbating A beta-mediated neuronal degeneration in AD and, when taken together with previous findings, suggest roles for oxidative stress induced by catecholamines in several different neurodegenerative conditions. Catecholamines 45-59 amyloid beta precursor protein Homo sapiens 76-82 9848093-11 1998 Collectively, these data indicate a role for catecholamines in exacerbating A beta-mediated neuronal degeneration in AD and, when taken together with previous findings, suggest roles for oxidative stress induced by catecholamines in several different neurodegenerative conditions. Catecholamines 215-229 amyloid beta precursor protein Homo sapiens 76-82 9727025-2 1998 For the catecholamine biosynthetic enzymes, dopamine beta-hydroxylase and tyrosine hydroxylase, regulation of gene expression by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis. Catecholamines 8-21 dopamine beta-hydroxylase Rattus norvegicus 44-69 9817549-2 1998 Immunohistochemical studies have confirmed the presence of catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the majority of fine, varicose intramuscular nerves, about two-thirds of which also contain neuropeptide Y (NPY). Catecholamines 59-72 neuropeptide Y Homo sapiens 254-268 9817549-2 1998 Immunohistochemical studies have confirmed the presence of catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta hydroxylase (DbetaH) in the majority of fine, varicose intramuscular nerves, about two-thirds of which also contain neuropeptide Y (NPY). Catecholamines 59-72 neuropeptide Y Homo sapiens 270-273 9733069-2 1998 PACAP peptides regulate rat superior cervical ganglion (SCG) neuron catecholamine and neuropeptide Y content and secretion, and promote sympathoneuroblast survival through activation of specific PACAP1 receptor isoforms. Catecholamines 68-81 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 9754624-1 1998 Tyrosine hydroxylase is the rate-limiting step in the biosynthesis of catecholamines. Catecholamines 70-84 tyrosine hydroxylase Homo sapiens 0-20 9794256-1 1998 Beta-adrenergic receptors transduce catecholamine binding to activation of adenylylcyclase, a response counter-regulated by insulin. Catecholamines 36-49 insulin Cricetulus griseus 124-131 9776344-3 1998 ET-1 (10(-7) M) significantly increased intracellular free Ca2+ level ([Ca2+]i), 45Ca2+ uptake and catecholamine secretion in the cells. Catecholamines 99-112 endothelin 1 Bos taurus 0-4 9776347-15 1998 These actions are probably related to the increase in catecholamine overflow, are beta-receptor-mediated and involve enhanced gene expression of COX-2. Catecholamines 54-67 cytochrome c oxidase subunit II Oryctolagus cuniculus 145-150 9776363-0 1998 Catecholamine transport by the organic cation transporter type 1 (OCT1). Catecholamines 0-13 solute carrier family 22 member 1 Homo sapiens 31-64 9776363-0 1998 Catecholamine transport by the organic cation transporter type 1 (OCT1). Catecholamines 0-13 solute carrier family 22 member 1 Homo sapiens 66-70 9776363-15 1998 The findings demonstrate that OCTI efficiently transports catecholamines and other biogenic amines and support the hypothesis that OCT1 is responsible for hepatic and renal inactivation of circulating catecholamines. Catecholamines 201-215 solute carrier family 22 member 1 Homo sapiens 131-135 9794256-2 1998 Insulin stimulates tyrosine phosphorylation of Tyr 350/354, which abolishes the catecholamine response. Catecholamines 80-93 insulin Cricetulus griseus 0-7 9794256-10 1998 These data provide a biochemical link between the ability of insulin to counter-regulate catecholamine stimulation of cyclic AMP accumulation and the phosphorylation of the beta-adrenergic receptor, consequent biding of the adaptor molecule Grb2 and disruption of receptor-G-protein coupling. Catecholamines 89-102 insulin Cricetulus griseus 61-68 9794256-10 1998 These data provide a biochemical link between the ability of insulin to counter-regulate catecholamine stimulation of cyclic AMP accumulation and the phosphorylation of the beta-adrenergic receptor, consequent biding of the adaptor molecule Grb2 and disruption of receptor-G-protein coupling. Catecholamines 89-102 growth factor receptor bound protein 2 Mus musculus 241-245 9736275-5 1998 Because norepinephrine increased 1.7-fold and 3.2-fold and plasma epinephrine increased 3.9-fold and 7.8-fold during hypoxia and CO inhalation, respectively, circulating catecholamines might mediate the stimulatory effects of hypoxia on renin secretion and renin gene expression. Catecholamines 170-184 renin Rattus norvegicus 237-242 9723178-1 1998 Cytosolic phenol sulfotransferases (PST) catalyze the sulfation/sulfonation of various phenolic agents, including catecholamines, thyroid hormones, and drugs (e.g., minoxidil and acetaminophen), which usually results in the inactivation and subsequent excretion of the compound. Catecholamines 114-128 sulfotransferase family 1A member 1 Homo sapiens 36-39 9736275-5 1998 Because norepinephrine increased 1.7-fold and 3.2-fold and plasma epinephrine increased 3.9-fold and 7.8-fold during hypoxia and CO inhalation, respectively, circulating catecholamines might mediate the stimulatory effects of hypoxia on renin secretion and renin gene expression. Catecholamines 170-184 renin Rattus norvegicus 257-262 9724817-2 1998 Recently, intraovarian neurons containing tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, were described in the ovary of nonhuman primates. Catecholamines 97-110 tyrosine hydroxylase Homo sapiens 42-62 9774217-6 1998 Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol. Catecholamines 182-195 lipoprotein(a) Homo sapiens 13-18 9774217-6 1998 Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol. Catecholamines 182-195 apolipoprotein B Homo sapiens 67-83 9774217-6 1998 Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol. Catecholamines 182-195 apolipoprotein B Homo sapiens 85-89 9774217-6 1998 Like LDL and Lp(a), a synthetic peptide homologous to human plasma apolipoprotein B (apoB), apoB fragment(3358-3372)-amide (3-60 microM), attenuated 22Na+ influx, 45Ca2+ influx, and catecholamine secretion caused by carbachol. Catecholamines 182-195 apolipoprotein B Homo sapiens 92-96 9774217-8 1998 These findings suggest that atherogenic lipoproteins such as LDL and Lp(a) suppress catecholamine secretion by interfering with Na+ influx through nicotinic acetylcholine receptor-ion channels, in which apoB, a structural component common to both LDL and Lp(a), plays an important role. Catecholamines 84-97 plasminogen Bos taurus 69-74 9774217-8 1998 These findings suggest that atherogenic lipoproteins such as LDL and Lp(a) suppress catecholamine secretion by interfering with Na+ influx through nicotinic acetylcholine receptor-ion channels, in which apoB, a structural component common to both LDL and Lp(a), plays an important role. Catecholamines 84-97 apolipoprotein B Bos taurus 203-207 9774217-2 1998 Low density lipoprotein (LDL: 20-80 mg/dl) and lipoprotein(a) [Lp(a); 10-80 mg/dl] inhibited catecholamine secretion induced by carbachol, an activator of nicotinic acetylcholine receptor-ion channels. Catecholamines 93-106 plasminogen Bos taurus 47-61 9774217-2 1998 Low density lipoprotein (LDL: 20-80 mg/dl) and lipoprotein(a) [Lp(a); 10-80 mg/dl] inhibited catecholamine secretion induced by carbachol, an activator of nicotinic acetylcholine receptor-ion channels. Catecholamines 93-106 plasminogen Bos taurus 63-68 9774217-4 1998 The inhibition of catecholamine secretion by Lp(a) was not overcome by increasing the concentration of carbachol. Catecholamines 18-31 plasminogen Bos taurus 45-50 9724817-2 1998 Recently, intraovarian neurons containing tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, were described in the ovary of nonhuman primates. Catecholamines 97-110 tyrosine hydroxylase Homo sapiens 64-66 9683442-0 1998 ANG II-related myocardial damage: role of cardiac sympathetic catecholamines and beta-receptor regulation. Catecholamines 62-76 angiotensinogen Rattus norvegicus 0-6 9845911-2 1998 Changes in cholinesterase activity and catecholamine content in histochemically active nerves following administration of cholinesterase (AChE) inhibiting agent phosphacol, seem to reflect compensatory responses to increasing dilatory cholinergic vasomotor effects under conditions of the AChE activity. Catecholamines 39-52 butyrylcholinesterase Rattus norvegicus 122-136 9845911-2 1998 Changes in cholinesterase activity and catecholamine content in histochemically active nerves following administration of cholinesterase (AChE) inhibiting agent phosphacol, seem to reflect compensatory responses to increasing dilatory cholinergic vasomotor effects under conditions of the AChE activity. Catecholamines 39-52 acetylcholinesterase Rattus norvegicus 138-142 9707588-0 1998 Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Catecholamines 82-95 catechol-O-methyltransferase Mus musculus 0-28 9707588-1 1998 Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. Catecholamines 115-129 catechol-O-methyltransferase Homo sapiens 0-28 9707588-1 1998 Catechol-O-methyltransferase (COMT) is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines and is considered a candidate for several psychiatric disorders and symptoms, including the psychopathology associated with the 22q11 microdeletion syndrome. Catecholamines 115-129 catechol-O-methyltransferase Homo sapiens 30-34 9707588-8 1998 Our results provide conclusive evidence for an important sex- and region-specific contribution of COMT in the maintenance of steady-state levels of catecholamines in the brain and suggest a role for COMT in some aspects of emotional and social behavior in mice. Catecholamines 148-162 catechol-O-methyltransferase Mus musculus 98-102 9681437-1 1998 Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates catecholamine release and biosynthesis in sympathetic postganglionic cells. Catecholamines 70-83 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-50 9679084-1 1998 The release of catecholamines from chromaffin cells involves specific proteins such as synaptobrevin present in the secretory vesicles as well as syntaxin and synaptosomal-associated protein of 25 kDa (SNAP-25), both present in the plasma membrane. Catecholamines 15-29 synaptosome associated protein 25 Homo sapiens 159-200 9681437-1 1998 Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates catecholamine release and biosynthesis in sympathetic postganglionic cells. Catecholamines 70-83 adenylate cyclase activating polypeptide 1 Rattus norvegicus 52-57 9681437-2 1998 Moreover, PACAP receptor activation in cultured adrenal chromaffin and superior cervical ganglion cells has been reported to increase the expression of the gene coding for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 227-240 adenylate cyclase activating polypeptide 1 Rattus norvegicus 10-15 9681437-2 1998 Moreover, PACAP receptor activation in cultured adrenal chromaffin and superior cervical ganglion cells has been reported to increase the expression of the gene coding for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 227-240 tyrosine hydroxylase Rattus norvegicus 172-192 9681437-2 1998 Moreover, PACAP receptor activation in cultured adrenal chromaffin and superior cervical ganglion cells has been reported to increase the expression of the gene coding for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 227-240 tyrosine hydroxylase Rattus norvegicus 194-196 9671372-8 1998 Catecholamine secretion in response to IL-1 and IL-2 (50 and 500 units/well, respectively), or nicotinic agonist dimethylphenylpiperazinium (10 microM, which mimics the action of acetylcholine), was tested for comparison. Catecholamines 0-13 interleukin 1 alpha Homo sapiens 39-43 9660778-15 1998 Even partial inhibition of betaARK1 activity enhances beta-adrenergic receptor signaling leading to improved functional catecholamine responsiveness. Catecholamines 120-133 G protein-coupled receptor kinase 2 Mus musculus 27-35 9675034-3 1998 In this study, we have thus examined the hypothesis that an additional source of free radicals may be hydrogen peroxide formed by the monoamine oxidase (MAO)-catalyzed deamination of catecholamines. Catecholamines 183-197 monoamine oxidase A Rattus norvegicus 153-156 9675034-10 1998 In conclusion, the estrogen receptor-mediated activation of MAO in conjunction with high catecholamine concentrations in the hamster kidney as previously reported may significantly increase the production of hydrogen peroxide and hydroxyl radicals which are postulated to contribute to tumor initiation. Catecholamines 89-102 monoamine oxidase A Rattus norvegicus 60-63 9721051-2 1998 Catecholamines as a stimulator of lipolysis and insulin as a suppressor play very important roles in the regulation of fat oxidation. Catecholamines 0-14 FAT atypical cadherin 1 Homo sapiens 119-122 9645680-9 1998 injection of IL-1beta activates a neural, catecholamine-dependent pathway that connects the brain and the testes independently of the pituitary. Catecholamines 42-55 interleukin 1 beta Homo sapiens 13-21 9671372-8 1998 Catecholamine secretion in response to IL-1 and IL-2 (50 and 500 units/well, respectively), or nicotinic agonist dimethylphenylpiperazinium (10 microM, which mimics the action of acetylcholine), was tested for comparison. Catecholamines 0-13 interleukin 2 Homo sapiens 48-52 9700679-4 1998 Intra-arterial administration of IL-1 beta (1 pg/kg) to otherwise untreated animals produced a prominent release of ACTH into the plasma, substantial c-fos expression in paraventricular medial parvocellular (mPVN) corticotropin releasing factor (CRF) cells, supraoptic (SON) and paraventricular nucleus (PVN) OT cells, area postrema cells, NTS and VLM catecholamine cells and cells of the central amygdala. Catecholamines 352-365 interleukin 1 beta Mus musculus 33-42 9636040-0 1998 Effects of phosphorylation of serine 40 of tyrosine hydroxylase on binding of catecholamines: evidence for a novel regulatory mechanism. Catecholamines 78-92 tyrosine hydroxylase Rattus norvegicus 43-63 9658190-4 1998 Chemical inhibition of either MAPK or MAPK kinase blocked the response of a transfected chromogranin A promoter to nicotine or protein kinase C activation [by phorbol-12-myristate-13-acetate (PMA)], although nicotine-evoked catecholamine secretion was unaffected. Catecholamines 224-237 chromogranin A Rattus norvegicus 88-102 9662372-3 1998 In vitro studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a beta-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. Catecholamines 44-58 interleukin 10 Homo sapiens 84-98 9702744-1 1998 Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. Catecholamines 75-89 catechol-O-methyltransferase Homo sapiens 0-28 9702744-1 1998 Catechol-O-methyltransferase (COMT) plays a major role in the breakdown of catecholamines. Catecholamines 75-89 catechol-O-methyltransferase Homo sapiens 30-34 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 17-21 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Catecholamines 81-95 catechol-O-methyltransferase Homo sapiens 113-117 9636040-5 1998 These results support a novel mechanism for regulation in which phosphorylation affects binding of catecholamines to the catalytically inactive ferric form of the tyrosine hydroxylase. Catecholamines 99-113 tyrosine hydroxylase Rattus norvegicus 163-183 9637684-8 1998 Accordingly, catecholamine levels in mutant embryos are severely decreased, and we suggest that the lack of catecholamines contributes to the embryonal lethality of the erbB3 mutant mice. Catecholamines 13-26 erb-b2 receptor tyrosine kinase 3 Mus musculus 169-174 9637684-8 1998 Accordingly, catecholamine levels in mutant embryos are severely decreased, and we suggest that the lack of catecholamines contributes to the embryonal lethality of the erbB3 mutant mice. Catecholamines 108-122 erb-b2 receptor tyrosine kinase 3 Mus musculus 169-174 9651737-4 1998 It has been clearly shown that angiotensin converting enzyme (ACE) inhibitors exert particularly beneficial effects in heart failure patients with raised catecholamine levels. Catecholamines 154-167 angiotensin I converting enzyme Homo sapiens 31-60 9663564-0 1998 Catecholamines and lipopolysaccharide synergistically induce the release of interleukin-6 from thymic epithelial cells. Catecholamines 0-14 interleukin 6 Rattus norvegicus 76-89 9663564-2 1998 We investigated the influence of catecholamines on the synthesis of interleukin-1 (IL-1) and IL-6 by cultured rat thymic epithelial cells. Catecholamines 33-47 interleukin 6 Rattus norvegicus 93-97 9663564-4 1998 Release of IL-6 was stimulated only scarcely by catecholamines or tumor necrosis factor-alpha (TNF-alpha) and moderately by LPS alone. Catecholamines 48-62 interleukin 6 Rattus norvegicus 11-15 9663564-9 1998 After co-stimulation IL-6 mRNA was first detected after 3-4 h and a constant increase of IL-6 bioactivity in the culture supernatant was measured for up to 48 h. Since IL-6 is an important factor for thymocyte differentiation and proliferation, the findings demonstrate an influence of neuronal or hormonal catecholamines on the thymic microenvironment that is created by thymic epithelial cells. Catecholamines 307-321 interleukin 6 Rattus norvegicus 21-25 9663564-9 1998 After co-stimulation IL-6 mRNA was first detected after 3-4 h and a constant increase of IL-6 bioactivity in the culture supernatant was measured for up to 48 h. Since IL-6 is an important factor for thymocyte differentiation and proliferation, the findings demonstrate an influence of neuronal or hormonal catecholamines on the thymic microenvironment that is created by thymic epithelial cells. Catecholamines 307-321 interleukin 6 Rattus norvegicus 89-93 9663564-9 1998 After co-stimulation IL-6 mRNA was first detected after 3-4 h and a constant increase of IL-6 bioactivity in the culture supernatant was measured for up to 48 h. Since IL-6 is an important factor for thymocyte differentiation and proliferation, the findings demonstrate an influence of neuronal or hormonal catecholamines on the thymic microenvironment that is created by thymic epithelial cells. Catecholamines 307-321 interleukin 6 Rattus norvegicus 89-93 9651737-4 1998 It has been clearly shown that angiotensin converting enzyme (ACE) inhibitors exert particularly beneficial effects in heart failure patients with raised catecholamine levels. Catecholamines 154-167 angiotensin I converting enzyme Homo sapiens 62-65 9694565-6 1998 On the contrary, there are indications that NPY may indirectly stimulate ZG cells, by eliciting the release of catecholamines, which in turn enhance aldosterone secretion. Catecholamines 111-125 neuropeptide Y Homo sapiens 44-47 9628757-5 1998 Catecholamine neurons in these coplanar sections were labeled by immunostaining for tyrosine hydroxylase (TH) coupled with diaminobenzidine. Catecholamines 0-13 tyrosine hydroxylase Rattus norvegicus 84-104 9628757-5 1998 Catecholamine neurons in these coplanar sections were labeled by immunostaining for tyrosine hydroxylase (TH) coupled with diaminobenzidine. Catecholamines 0-13 tyrosine hydroxylase Rattus norvegicus 106-108 9641484-1 1998 Nepicastat (RS-25560-197) is a novel, selective, and potent inhibitor of dopamine beta-hydroxylase, which modulates catecholamine levels (reduces norepinephrine and elevates dopamine) in cardiovascular tissues. Catecholamines 116-129 dopamine beta-hydroxylase Rattus norvegicus 73-98 9626157-2 1998 Presence in pheochromocytomas of catechol-O-methyltransferase (COMT), the enzyme responsible for conversion of catecholamines to metanephrines, was confirmed by Western blot analysis, enzyme assay, and immunohistochemistry. Catecholamines 111-125 catechol-O-methyltransferase Homo sapiens 33-61 9626157-2 1998 Presence in pheochromocytomas of catechol-O-methyltransferase (COMT), the enzyme responsible for conversion of catecholamines to metanephrines, was confirmed by Western blot analysis, enzyme assay, and immunohistochemistry. Catecholamines 111-125 catechol-O-methyltransferase Homo sapiens 63-67 9654359-7 1998 These studies demonstrate that NO may serve as an important regulatory mechanism for catecholamine secretion in chromaffin cells via the activation of KCa channels. Catecholamines 85-98 casein kappa Homo sapiens 151-154 9626157-4 1998 Immunohistochemistry revealed colocalization of COMT in the same chromaffin cells where catecholamines are translocated into storage vesicles by the vesicular monoamine transporter. Catecholamines 88-102 catechol-O-methyltransferase Homo sapiens 48-52 9603199-5 1998 LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one], a potent inhibitor of PI 3-kinase, produced a dose-dependent inhibition of catecholamine secretion evoked by various secretagogues. Catecholamines 136-149 peptidase inhibitor 3 Homo sapiens 83-87 9603199-7 1998 Our results suggest that PI 3-kinase may be one of the important regulatory exocytotic components involved in the signaling cascade controlling actin rearrangements required for catecholamine secretion. Catecholamines 178-191 peptidase inhibitor 3 Homo sapiens 25-29 9552127-4 1998 In the present study, we sought to identify the subcellular substrates underlying alpha2C-AR actions in the LC by analyzing the ultrastructural distribution of alpha2C-AR immunoreactivity (alpha2C-AR-IR) in sections that were dually labeled for the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH). Catecholamines 249-262 adrenoceptor alpha 2C Rattus norvegicus 82-92 9686908-1 1998 Neuropeptide Y (NPY) is a neurotransmitter released from cardiac sympathetic nerve terminals along with catecholamines. Catecholamines 104-118 neuropeptide Y Homo sapiens 0-14 9686908-1 1998 Neuropeptide Y (NPY) is a neurotransmitter released from cardiac sympathetic nerve terminals along with catecholamines. Catecholamines 104-118 neuropeptide Y Homo sapiens 16-19 9612216-1 1998 We previously demonstrated, using rat PC-12 pheochromocytoma cells differentiated to a sympathetic neuronal phenotype with nerve growth factor (NGF), that neuropeptide Y (NPY) inhibits catecholamine synthesis as well as release. Catecholamines 185-198 neuropeptide Y Rattus norvegicus 155-169 9612216-1 1998 We previously demonstrated, using rat PC-12 pheochromocytoma cells differentiated to a sympathetic neuronal phenotype with nerve growth factor (NGF), that neuropeptide Y (NPY) inhibits catecholamine synthesis as well as release. Catecholamines 185-198 neuropeptide Y Rattus norvegicus 171-174 9629270-3 1998 In turn, CRF and VP synthesis and/or release is modulated by catecholamines, prostaglandins (PGs), and nitric oxide (NO). Catecholamines 61-75 arginine vasopressin Rattus norvegicus 17-19 9629247-9 1998 On the other hand, central depletion of catecholamines exacerbates IL-1-induced hypoglycemia. Catecholamines 40-54 interleukin 1 complex Mus musculus 67-71 9629296-6 1998 In addition, catecholamines induce the production of IL-6 by leukocytes of these patients, via triggering of alpha 1-adrenergic receptors. Catecholamines 13-27 interleukin 6 Homo sapiens 53-57 9629305-5 1998 During APR, LPS-binding proteins (LBP) are produced by the liver in rapidly increasing quantities under the influence of interleukin-6, glucocorticoids, and catecholamines. Catecholamines 157-171 phorbol-12-myristate-13-acetate-induced protein 1 Homo sapiens 7-10 9643450-8 1998 It has previously been shown that at low doses Rb1 and Rg1 are equally effective at inhibition of catecholamine secretion at the pre-synaptic site, but that at high doses Rg1 is a more effective inhibitor. Catecholamines 98-111 RB transcriptional corepressor 1 Mus musculus 47-50 9591841-1 1998 Tyrosine hydroxylase of catecholamine neurons catalyzes the synthesis of 3,4-dihydroxphenylalanine (DOPA), which is subsequently metabolized to dopamine by DOPA decarboxylase (DDC). Catecholamines 24-37 dopa decarboxylase Rattus norvegicus 156-174 9591841-1 1998 Tyrosine hydroxylase of catecholamine neurons catalyzes the synthesis of 3,4-dihydroxphenylalanine (DOPA), which is subsequently metabolized to dopamine by DOPA decarboxylase (DDC). Catecholamines 24-37 dopa decarboxylase Rattus norvegicus 176-179 9643450-8 1998 It has previously been shown that at low doses Rb1 and Rg1 are equally effective at inhibition of catecholamine secretion at the pre-synaptic site, but that at high doses Rg1 is a more effective inhibitor. Catecholamines 98-111 protein phosphatase 1, regulatory subunit 3A Mus musculus 55-58 9861628-4 1998 The results indicate that: 1) CCK-33 enhances the influence of catecholamines: noradrenaline and isoprenaline, mainly on the function of isolated heart. Catecholamines 63-77 cholecystokinin Rattus norvegicus 30-33 9572154-12 1998 These results indicate that the response to the treatment with the antiserum to substance P shows considerable alterations in transgenic mice as compared with their litter-mate, normal controls, producing divergent effects on hypothalamic catecholamine metabolism. Catecholamines 239-252 tachykinin 1 Mus musculus 80-91 9861628-16 1998 CCK-related peptides may increase or reduce the effects of catecholamines indirectly through activation of alpha-adrenoceptors. Catecholamines 59-73 cholecystokinin Rattus norvegicus 0-3 9703624-4 1998 The administration of MAO a inhibitor pyrazidol promoted the increase in brain serotonin content, normalized brain catecholamine contents and demonstrated positive effect on the animal state. Catecholamines 115-128 monoamine oxidase A Homo sapiens 22-27 9675879-1 1998 In the presence of hydrogen peroxide cytochrome c can perform the oxidation of catecholamines and their S-cysteinyl-derivatives yielding melanins as final products. Catecholamines 79-93 cytochrome c, somatic Homo sapiens 37-49 9578504-2 1998 METHODS: We measured the concentrations of mRNA coding for the catecholamine-synthesizing enzymes tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT) and for the catecholamine contents in 12 pheochromocytomas and 12 normal adrenal medullas. Catecholamines 63-76 dopamine beta-hydroxylase Homo sapiens 191-194 9578504-2 1998 METHODS: We measured the concentrations of mRNA coding for the catecholamine-synthesizing enzymes tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT) and for the catecholamine contents in 12 pheochromocytomas and 12 normal adrenal medullas. Catecholamines 63-76 phenylethanolamine N-methyltransferase Homo sapiens 200-239 9578504-2 1998 METHODS: We measured the concentrations of mRNA coding for the catecholamine-synthesizing enzymes tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT) and for the catecholamine contents in 12 pheochromocytomas and 12 normal adrenal medullas. Catecholamines 63-76 phenylethanolamine N-methyltransferase Homo sapiens 241-245 9590505-8 1998 Concomitantly, the expression of phenylethanolamine-N-methyl transferase (PNMT), but not of other catecholamine synthesizing enzymes, was enhanced. Catecholamines 98-111 phenylethanolamine-N-methyltransferase Rattus norvegicus 33-72 9590505-8 1998 Concomitantly, the expression of phenylethanolamine-N-methyl transferase (PNMT), but not of other catecholamine synthesizing enzymes, was enhanced. Catecholamines 98-111 phenylethanolamine-N-methyltransferase Rattus norvegicus 74-78 9502265-4 1998 The present study using the cat carotid body demonstrates profound changes in the levels of immunoreactivity of the catecholamine-synthesizing enzyme, tyrosine hydroxylase, and the neuropeptide, substance P, in response to a two-week exposure to hypoxia (10% O2 in 90% N2). Catecholamines 116-129 tyrosine hydroxylase Homo sapiens 151-171 9510527-5 1998 In addition to erythropoietin, HIF-1-responsive genes include examples with functions in cellular energy metabolism, iron metabolism, catecholamine metabolism, vasomotor control and angiogenesis, suggesting an important role in the coordination of oxygen supply and cellular metabolism. Catecholamines 134-147 hypoxia inducible factor 1 subunit alpha Homo sapiens 31-36 9797201-1 1998 BACKGROUND: Neuropeptide Y, an abundant neurohormone present with catecholamines in the adrenal medulla, is a potent non-adrenergic vasoconstrictor and a vascular growth factor. Catecholamines 66-80 neuropeptide Y Homo sapiens 12-26 9642677-2 1998 Exposure of experimental animals to different stressors causes an increase in LC activity and gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 168-181 tyrosine hydroxylase Rattus norvegicus 113-133 9642677-2 1998 Exposure of experimental animals to different stressors causes an increase in LC activity and gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 168-181 tyrosine hydroxylase Rattus norvegicus 135-137 9642677-8 1998 Thus, our results indicate a possible adaptation of catecholamine-synthesizing system at the level of TH gene expression in LC of rats exposed to long-term repeated IMMO. Catecholamines 52-65 tyrosine hydroxylase Rattus norvegicus 102-104 9566389-3 1998 GCH1 is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for catecholamine synthesis. Catecholamines 109-122 GTP cyclohydrolase 1 Homo sapiens 0-4 9532347-3 1998 Distally, it includes the gene for catechol-O-methyl-transferase (COMT), an enzyme that catalyzes the O-methylation of catecholamine neurotransmitters, including dopamine, and which therefore is considered a candidate gene for schizophrenia. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 35-64 9564683-0 1998 TaqI polymorphic sites at the human dopamine beta-hydroxylase gene possibly associated with biochemical alterations of the catecholamine pathway in schizophrenia. Catecholamines 123-136 dopamine beta-hydroxylase Homo sapiens 36-61 9613851-1 1998 Tyrosine hydroxylase (TH) gene is the rate-limiting enzyme in the synthesis of catecholamines. Catecholamines 79-93 tyrosine hydroxylase Homo sapiens 0-20 9613851-1 1998 Tyrosine hydroxylase (TH) gene is the rate-limiting enzyme in the synthesis of catecholamines. Catecholamines 79-93 tyrosine hydroxylase Homo sapiens 22-24 9532347-3 1998 Distally, it includes the gene for catechol-O-methyl-transferase (COMT), an enzyme that catalyzes the O-methylation of catecholamine neurotransmitters, including dopamine, and which therefore is considered a candidate gene for schizophrenia. Catecholamines 119-132 catechol-O-methyltransferase Homo sapiens 66-70 9535125-1 1998 Catechol-O-methyltransferase (COMT) is an enzyme which inactivates catecholamine neurotransmitters by methylation, and is considered a candidate for involvement in schizophrenia. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 0-28 9518597-4 1998 The stimulation of catecholamine secretion in the presence of extracellular Ca2+ was concentration dependent up to 50 microM alamethicin. Catecholamines 19-32 carbonic anhydrase 2 Bos taurus 76-79 9578138-3 1998 Additionally, cDNA-polymerase chain reaction (cDNA-PCR) analysis of relative mRNA levels corresponding to the enzymes involved in catecholamine synthesis revealed a 3-fold increase of tyrosine hydroxylase gene expression after 5 days of incubation with ascorbic acid (200 microM), whereas expression of dopamine-beta-hydroxylase was found to be unaltered. Catecholamines 130-143 tyrosine hydroxylase Homo sapiens 184-204 9578138-3 1998 Additionally, cDNA-polymerase chain reaction (cDNA-PCR) analysis of relative mRNA levels corresponding to the enzymes involved in catecholamine synthesis revealed a 3-fold increase of tyrosine hydroxylase gene expression after 5 days of incubation with ascorbic acid (200 microM), whereas expression of dopamine-beta-hydroxylase was found to be unaltered. Catecholamines 130-143 dopamine beta-hydroxylase Homo sapiens 303-328 9600661-19 1998 endothelin-1 are due to an intense pulmonary vasoconstriction mediated by alpha-adrenoceptors following the release of catecholamines in response to the activation of endothelin ET(A) receptor in the spinal cord. Catecholamines 119-133 endothelin 1 Rattus norvegicus 0-12 9480878-1 1998 In rats, the daily changes in hepatic lipase (HL) activity in the liver follow the diurnal rhythm of the catecholamines. Catecholamines 105-119 lipase C, hepatic type Rattus norvegicus 30-44 9486829-3 1998 The present study utilized injections of the highly sensitive anterograde tracer substance biotinylated dextran combined with immunocytochemistry for tyrosine hydroxylase, the synthesizing enzyme for catecholamines, to investigate the distribution and morphology of projections from the spinal trigeminal subnucleus caudalis to ventral medullary and pontine catecholaminergic cell groups. Catecholamines 200-214 tyrosine hydroxylase Rattus norvegicus 150-170 9466982-16 1998 Thus, PACAP-evoked chromogranin A transcription and catecholamine secretion are likely mediated by the PACAP/VIP type I receptor isoform. Catecholamines 52-65 vasoactive intestinal peptide Rattus norvegicus 109-112 9645965-1 1998 The tyrosine hydroxylase (TH) gene encodes the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 91-105 tyrosine hydroxylase Rattus norvegicus 4-24 9645965-1 1998 The tyrosine hydroxylase (TH) gene encodes the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 91-105 tyrosine hydroxylase Rattus norvegicus 26-28 9566731-1 1998 Phenol sulfotransferases (PST) catalyze the sulfonation of catecholamines, thyroid hormones and phenolic drugs. Catecholamines 59-73 sulfotransferase family 1A member 1 Homo sapiens 26-29 9466982-14 1998 The potent PACAP/vasoactive intestinal peptide (VIP) type I receptor antagonist PACAP6-38 impaired both chromogranin A transcription or catecholamine secretion triggered by PACAP38, while the PACAP/VIP type II receptor antagonist (p-Chloro-D-Phe6, Leu17)-VIP had little or no ability to antagonize the PACAP38 effect. Catecholamines 136-149 vasoactive intestinal peptide Rattus norvegicus 48-51 9535125-1 1998 Catechol-O-methyltransferase (COMT) is an enzyme which inactivates catecholamine neurotransmitters by methylation, and is considered a candidate for involvement in schizophrenia. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 30-34 9449645-10 1998 CRH affected several parameters of KAT45 cell metabolism, including their proliferation rate, synthesis of catecholamines, and production of POMC-derived peptides. Catecholamines 107-121 corticotropin releasing hormone Homo sapiens 0-3 9476901-5 1998 Immunohistochemistry for substance P, a substance P enzyme immunoassay, and catecholamine histofluorescence indicated that both tachykinin-containing sensory fibers and sympathetic fibers were increased around the airways of CCSP-NGF mice. Catecholamines 76-89 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 225-229 9449684-10 1998 This decreased sensitivity to Ang II-induced pressor action was mainly due to the AT2-mediated strong negative chronotropic effect and exerted by circulating Ang II in a physiological range that did not stimulate catecholamine release. Catecholamines 213-226 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 30-36 9553751-3 1998 ANG-II (10(-9) M) evoked a marked rise in the secretion of aldosterone by dispersed ZG cells and catecholamines by AM fragments. Catecholamines 97-111 angiotensinogen Rattus norvegicus 0-6 9553751-5 1998 Catecholamine response to ANG-II was inhibited by PD123319 and only moderately affected by high concentrations of DuP753. Catecholamines 0-13 angiotensinogen Rattus norvegicus 26-32 9553751-6 1998 The selective AT2-receptor agonist CGP42112 did not change basal aldosterone release of ZG cells, but concentration-dependently enhanced basal catecholamine release by AM fragments. Catecholamines 143-156 angiotensin II receptor, type 2 Rattus norvegicus 14-17 9553752-0 1998 The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats. Catecholamines 49-62 angiotensin II receptor, type 2 Rattus norvegicus 4-7 9553752-0 1998 The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats. Catecholamines 49-62 angiotensin II receptor, type 1a Rattus norvegicus 90-93 9553752-0 1998 The AT2 receptor-mediated stimulation of adrenal catecholamine release may potentiate the AT1 receptor-mediated aldosterone secretagogue action of angiotensin-II in rats. Catecholamines 49-62 angiotensinogen Rattus norvegicus 147-161 9553752-6 1998 The activation of AT2 receptors probably elicits the local release of catecholamines, which in turn enhance aldosterone secretion in a paracrine manner acting through the beta-adrenoceptors with which ZG cells are provided. Catecholamines 70-84 angiotensin II receptor, type 2 Rattus norvegicus 18-21 9449684-10 1998 This decreased sensitivity to Ang II-induced pressor action was mainly due to the AT2-mediated strong negative chronotropic effect and exerted by circulating Ang II in a physiological range that did not stimulate catecholamine release. Catecholamines 213-226 serine (or cysteine) peptidase inhibitor, clade B, member 9d Mus musculus 82-85 9453523-12 1998 Unlike patients with cardioinhibitory syncope, the renin-angiotensin-aldosterone axis is activated in patients with vasodepressor syncope and patients with a negative result of head-up tilt test without a statistically significant increase in catecholamine levels. Catecholamines 243-256 renin Homo sapiens 51-56 9621392-7 1998 A reduction in the modulatory effect of these catecholamines (by neurotoxic lesion, synthetic enzyme inhibitors or adrenergic receptor antagonists) resulted in an inhibition of nicotine-stimulated ACTH secretion. Catecholamines 46-60 proopiomelanocortin Homo sapiens 197-201 9574865-1 1998 Recently we have found that hypercapnia induces nuclear protein (FOS) expression in the brainstem chemosensitive neurons, including catecholamine-containing cells. Catecholamines 132-145 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 65-68 9430671-8 1998 Furthermore, a synthetic myristoylated peptide corresponding to the N-terminal domain of ARF6 inhibited both PLD activity and catecholamine secretion in calcium-stimulated chromaffin cells. Catecholamines 126-139 ADP ribosylation factor 6 Homo sapiens 89-93 9781323-3 1998 The primary regulators of adipose tissue lipolysis, the catecholamines, bind to the alpha 2, beta 1, beta 2, and beta 3 adrenergic receptors. Catecholamines 56-70 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 101-107 9458725-1 1998 In the current study, we investigated links between O2-regulated H2O2 formation and the hypoxic induction of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in O2-sensitive PC-12 cells. Catecholamines 173-186 tyrosine hydroxylase Rattus norvegicus 118-138 9754371-19 1998 Inactivation of catecholamines is mediated by catechol-O-methyltransferase and by the monoamine oxidases A and B. Catecholamines 16-30 catechol-O-methyltransferase Homo sapiens 46-74 9458725-1 1998 In the current study, we investigated links between O2-regulated H2O2 formation and the hypoxic induction of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in O2-sensitive PC-12 cells. Catecholamines 173-186 tyrosine hydroxylase Rattus norvegicus 140-142 9871458-4 1998 Much exogenously administered 6-OHDOPA is biotransformed by aminoacid decarboxylase (AADC) to the highly potent and catecholamine-(CA) selective neurotoxin, 6-hydroxydopamine (6-OHDA). Catecholamines 116-129 dopa decarboxylase Homo sapiens 85-89 9754371-19 1998 Inactivation of catecholamines is mediated by catechol-O-methyltransferase and by the monoamine oxidases A and B. Catecholamines 16-30 monoamine oxidase A Homo sapiens 86-112 9831308-0 1998 Evidence for inhibition of leptin secretion by catecholamines in man. Catecholamines 47-61 leptin Homo sapiens 27-33 9833158-7 1998 It is concluded that AT1 antagonists inhibit angiotensin II mediated catecholamine release on presynaptic sympathetic nerves and the adrenal medulla at the specific AT1 receptor site. Catecholamines 69-82 angiotensin II receptor, type 1a Rattus norvegicus 21-24 9833158-7 1998 It is concluded that AT1 antagonists inhibit angiotensin II mediated catecholamine release on presynaptic sympathetic nerves and the adrenal medulla at the specific AT1 receptor site. Catecholamines 69-82 angiotensinogen Rattus norvegicus 45-59 9833158-7 1998 It is concluded that AT1 antagonists inhibit angiotensin II mediated catecholamine release on presynaptic sympathetic nerves and the adrenal medulla at the specific AT1 receptor site. Catecholamines 69-82 angiotensin II receptor, type 1a Rattus norvegicus 165-168 9833160-7 1998 AT1 mediates myocyte hypertrophy, fibroblast proliferation, collagen synthesis, smooth muscle cell growth, endothelial adhesion molecule expression, and catecholamine synthesis. Catecholamines 153-166 angiotensin II receptor type 1 Homo sapiens 0-3 9467687-10 1998 A catechol-O-methyltransferase (COMT) inhibitor combined with an MAO inhibitor might synergistically maximise the levels of catecholamines in the CNS. Catecholamines 124-138 catechol-O-methyltransferase Homo sapiens 2-30 9467687-10 1998 A catechol-O-methyltransferase (COMT) inhibitor combined with an MAO inhibitor might synergistically maximise the levels of catecholamines in the CNS. Catecholamines 124-138 catechol-O-methyltransferase Homo sapiens 32-36 9831308-8 1998 In conclusion our results indicate that catecholamines play a suppressive role in the regulation of leptin secretion. Catecholamines 40-54 leptin Homo sapiens 100-106 9831308-2 1998 Insulin has been shown to stimulate leptin secretion in humans, whereas in vitro data suggest that catecholamines inhibit leptin secretion. Catecholamines 99-113 leptin Homo sapiens 122-128 9451618-0 1998 Effects of CO2-HCO3- on catecholamine efflux from cat carotid body. Catecholamines 24-37 complement C2 Homo sapiens 11-14 9453333-3 1998 In conscious chronically instrumented rats, we measured plasma concentrations of catecholamines during acute insulin-induced hypoglycemia in groups of rats pretreated with the AT1 receptor antagonist losartan (10 mg/kg i.v. Catecholamines 81-95 insulin Homo sapiens 109-116 9666567-5 1998 IL-2, IL-3, IL-6, and INF-alpha are able to directly stimulate glucocorticoid production by zona fasciculata and zona reticularis cells, whereas IL-1 exerts an analogous effect through an indirect mechanism involving the stimulation of catecholamine release by chromaffin cells and/or the activation of the intramedullary CRH/ACTH system; again, TNF-alpha depresses glucocorticoid synthesis. Catecholamines 236-249 interleukin 2 Homo sapiens 0-4 9666567-5 1998 IL-2, IL-3, IL-6, and INF-alpha are able to directly stimulate glucocorticoid production by zona fasciculata and zona reticularis cells, whereas IL-1 exerts an analogous effect through an indirect mechanism involving the stimulation of catecholamine release by chromaffin cells and/or the activation of the intramedullary CRH/ACTH system; again, TNF-alpha depresses glucocorticoid synthesis. Catecholamines 236-249 interleukin 6 Homo sapiens 12-16 9666567-5 1998 IL-2, IL-3, IL-6, and INF-alpha are able to directly stimulate glucocorticoid production by zona fasciculata and zona reticularis cells, whereas IL-1 exerts an analogous effect through an indirect mechanism involving the stimulation of catecholamine release by chromaffin cells and/or the activation of the intramedullary CRH/ACTH system; again, TNF-alpha depresses glucocorticoid synthesis. Catecholamines 236-249 interferon alpha 17 Homo sapiens 22-31 9464467-0 1998 Atrial natriuretic peptide mediated alterations in catecholamine and indoleamine turnover in the nucleus of the solitary tract of rats. Catecholamines 51-64 natriuretic peptide A Rattus norvegicus 0-26 9595440-8 1998 Increased ET-1 content and receptors may lead to hypersecretion of catecholamine in PHEO. Catecholamines 67-80 endothelin 1 Homo sapiens 10-14 9595440-9 1998 ET-1 produced in normal and tumor adrenal tissues may regulate aldosterone and catecholamine secretion from adrenals in a paracrine/autocrine fashion. Catecholamines 79-92 endothelin 1 Homo sapiens 0-4 9510060-10 1998 The blunted plasma catecholamine responses after central AT1 receptor blockade indicate that endogenous Ang II in the brain is required for sympathoadrenal activation during immobilization stress. Catecholamines 19-32 angiotensin II receptor, type 1a Rattus norvegicus 57-60 9510060-10 1998 The blunted plasma catecholamine responses after central AT1 receptor blockade indicate that endogenous Ang II in the brain is required for sympathoadrenal activation during immobilization stress. Catecholamines 19-32 angiotensinogen Rattus norvegicus 104-110 9661134-1 1998 It has been demonstrated in isolated organs that angiotensin II mediates catecholamine release via presynaptically located AT1 receptor subtypes. Catecholamines 73-86 angiotensinogen Rattus norvegicus 49-63 9661134-1 1998 It has been demonstrated in isolated organs that angiotensin II mediates catecholamine release via presynaptically located AT1 receptor subtypes. Catecholamines 73-86 angiotensin II receptor, type 1a Rattus norvegicus 123-126 9661134-8 1998 The results indicate an AT1 receptor subtype mediated release of catecholamines in a whole-animal model. Catecholamines 65-79 angiotensin II receptor, type 1a Rattus norvegicus 24-27 9718091-9 1998 The findings indicate that in women leptin levels are not associated with cyclic changes in estrogen or progesterone but may be associated with catecholamine levels. Catecholamines 144-157 leptin Homo sapiens 36-42 9619850-4 1998 Tyrosine hydroxylase (TH) catalyzes the initial rate-limiting step of catecholamine biosynthesis in the nervous system. Catecholamines 70-83 tyrosine hydroxylase Rattus norvegicus 0-20 9619850-4 1998 Tyrosine hydroxylase (TH) catalyzes the initial rate-limiting step of catecholamine biosynthesis in the nervous system. Catecholamines 70-83 tyrosine hydroxylase Rattus norvegicus 22-24 9500857-3 1998 In adipocytes, activation of the membrane-associated PDE3B is the major mechanism whereby insulin antagonizes catecholamine-induced lipolysis. Catecholamines 110-123 phosphodiesterase 3B Rattus norvegicus 53-58 9786174-1 1998 Catestatin (bovine chromogranin A(344-364); RSMRLSFRARGYGFRGPGLQL), reduces catecholamine secretion from chromaffin cells in vitro. Catecholamines 76-89 chromogranin A Bos taurus 19-33 9606669-2 1998 Analysis of change dynamics of acetyl cholinesterase catecholamine ratio influenced by NGF demonstrated its dependence on the cell type. Catecholamines 53-66 nerve growth factor Homo sapiens 87-90 9809661-10 1998 VIP and PACAP raise aldosterone production via a paracrine indirect mechanism involving the stimulation of medullary chromaffin cells to release catecholamines, which in turn enhance the secretion of zona glomerulosa cells via a beta-adrenoceptor-mediated mechanism. Catecholamines 145-159 vasoactive intestinal peptide Rattus norvegicus 0-3 9809661-10 1998 VIP and PACAP raise aldosterone production via a paracrine indirect mechanism involving the stimulation of medullary chromaffin cells to release catecholamines, which in turn enhance the secretion of zona glomerulosa cells via a beta-adrenoceptor-mediated mechanism. Catecholamines 145-159 adenylate cyclase activating polypeptide 1 Rattus norvegicus 8-13 9690657-4 1998 The prostate has a high density of alpha-1 and beta-2 adrenergic receptors, and the presence of these receptors, as well as their regulation by androgens, suggests and supports the direct mitogenic effect of catecholamines on prostate growth. Catecholamines 208-222 adrenoceptor alpha 1D Homo sapiens 35-42 9861640-1 1998 Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. Catecholamines 94-108 catechol-O-methyltransferase Homo sapiens 0-28 9861640-1 1998 Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline. Catecholamines 94-108 catechol-O-methyltransferase Homo sapiens 30-34 9395518-8 1997 However, in primary cultures of brown adipocytes, a synergistic action of norepinephrine and dexamethasone was required for full expression of the gene, indicating that both catecholamines and glucocorticoids are required for the induction of Cig30. Catecholamines 174-188 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 243-248 9453454-0 1997 Interferon-alpha reduces catecholamine secretion from bovine adrenal chromaffin cells stimulated by acetylcholine. Catecholamines 25-38 INFA Bos taurus 0-16 9435537-0 1997 Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation. Catecholamines 0-14 tumor necrosis factor Homo sapiens 33-36 9435537-0 1997 Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation. Catecholamines 0-14 tumor necrosis factor Homo sapiens 59-62 9435537-0 1997 Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation. Catecholamines 0-14 adrenoceptor beta 2 Homo sapiens 71-92 9435537-3 1997 Also, catecholamines inhibit TNF production, but the adrenoreceptor mechanism of this effect has not been fully clarified. Catecholamines 6-20 tumor necrosis factor Homo sapiens 29-32 9512819-13 1997 The findings indicate that L-selectin expression influences T-cell trafficking in response to beta-adrenergic stimulation and help further illuminate catecholamine-mediated sympathetic and immune interactions. Catecholamines 150-163 selectin L Homo sapiens 27-37 9405118-3 1997 In addition, the catecholamine-synthesizing enzymes tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine N-methyltransferase were immunocytochemically localized for the characterization of chromaffin adrenal cells. Catecholamines 17-30 dopamine beta-hydroxylase (dopamine beta-monooxygenase) L homeolog Xenopus laevis 74-99 9436100-1 1997 Increased sympathetic activity, including peripheral release of catecholamines, has been hypothesized to inhibit the milk ejection reflex by blocking the release of oxytocin, by blocking the effect of oxytocin at the mammary gland, or both. Catecholamines 64-78 oxytocin/neurophysin I prepropeptide Homo sapiens 165-173 9436100-1 1997 Increased sympathetic activity, including peripheral release of catecholamines, has been hypothesized to inhibit the milk ejection reflex by blocking the release of oxytocin, by blocking the effect of oxytocin at the mammary gland, or both. Catecholamines 64-78 oxytocin/neurophysin I prepropeptide Homo sapiens 201-209 9453454-3 1997 The content of catecholamines in the cells treated with IFN-alpha-2b for 72 h did not change. Catecholamines 15-29 interferon alpha-A Bos taurus 56-65 9453454-7 1997 These results strongly suggest that IFN-alpha-2b reduces the ACh-induced secretion of catecholamines from bovine adrenal chromaffin cells due to modulating the gene expression of the nicotinic ACh receptor-operated cation channels rather than due to directly affecting the channels. Catecholamines 86-100 interferon alpha-A Bos taurus 36-45 9415712-2 1997 The addition of neuropeptide Y (NPY) to the culture medium prevents the increase in catecholamine synthesis but not secretion. Catecholamines 84-97 neuropeptide Y Bos taurus 16-30 9415712-2 1997 The addition of neuropeptide Y (NPY) to the culture medium prevents the increase in catecholamine synthesis but not secretion. Catecholamines 84-97 neuropeptide Y Bos taurus 32-35 9432090-2 1997 COMT inactivates catecholamines and converts primary catecholestrogens (CE) into their O-methylated form yielding the 2- (2-MeOE) and 4-methoxyestrogens (4-MeOE). Catecholamines 17-31 catechol-O-methyltransferase Homo sapiens 0-4 9453454-1 1997 A long-term pretreatment (72 h) of bovine adrenal chromaffin cells with recombinant human interferon (IFN) -alpha-2b (1500 units/ml) produced a decrease in the secretion of catecholamines from the cells stimulated by acetylcholine (ACh) (25 micromol/l) but not that with human fibloblast IFN-beta (3000 units/ml) or recombinant human IFN-gamma (3000 units/ml). Catecholamines 173-187 interferon alpha 2 Homo sapiens 90-116 9453454-1 1997 A long-term pretreatment (72 h) of bovine adrenal chromaffin cells with recombinant human interferon (IFN) -alpha-2b (1500 units/ml) produced a decrease in the secretion of catecholamines from the cells stimulated by acetylcholine (ACh) (25 micromol/l) but not that with human fibloblast IFN-beta (3000 units/ml) or recombinant human IFN-gamma (3000 units/ml). Catecholamines 173-187 interferon beta 1 Homo sapiens 288-296 9453454-1 1997 A long-term pretreatment (72 h) of bovine adrenal chromaffin cells with recombinant human interferon (IFN) -alpha-2b (1500 units/ml) produced a decrease in the secretion of catecholamines from the cells stimulated by acetylcholine (ACh) (25 micromol/l) but not that with human fibloblast IFN-beta (3000 units/ml) or recombinant human IFN-gamma (3000 units/ml). Catecholamines 173-187 interferon gamma Homo sapiens 334-343 9398650-3 1997 DAT represents an important target for widely used neuroleptic drugs and psychostimulants and for catecholamine-selective neurotoxins. Catecholamines 98-111 solute carrier family 6 member 3 Homo sapiens 0-3 9409754-4 1997 In situ hybridization analysis has shown that RST gene expression is restricted to the renal proximal tubule, where various organic cations such as endogenous catecholamines and choline or clinically used cationic drugs are known to be actively excreted. Catecholamines 159-173 solute carrier family 22 (organic anion/cation transporter), member 12 Mus musculus 46-49 9353359-3 1997 As a consequence of the redox chemistry of the selenium moiety, phenylaminoalkyl selenides possess the remarkable characteristic of propagating a cycle of turnover-dependent local depletion of reduced ascorbate when processed by the key enzyme of catecholamine metabolism, dopamine-beta-monooxygenase. Catecholamines 247-260 dopamine beta-hydroxylase Rattus norvegicus 273-300 9353340-1 1997 Catecholamines as well as phorbol esters can induce the phosphorylation and desensitization of the alpha1B-adrenergic receptor (alpha1BAR). Catecholamines 0-14 adrenoceptor alpha 1B Homo sapiens 99-126 9353340-1 1997 Catecholamines as well as phorbol esters can induce the phosphorylation and desensitization of the alpha1B-adrenergic receptor (alpha1BAR). Catecholamines 0-14 adrenoceptor alpha 1B Homo sapiens 128-137 9353354-0 1997 Atrial natriuretic peptide inhibits evoked catecholamine release by altering sensitivity to calcium. Catecholamines 43-56 natriuretic peptide A Rattus norvegicus 0-26 9349551-3 1997 We compared catecholamine synthesis in vitro in cultures of cells with tyrosine hydroxylase and aromatic L-amino acid decarboxylase together versus cocultures of cells containing these enzymes separately. Catecholamines 12-25 dopa decarboxylase Rattus norvegicus 96-131 9503561-12 1997 In rat and primate brain MAO-A is restricted to catecholamine neurons, while MAO-B is largely restricted to serotonin neurons and astrocytes. Catecholamines 48-61 monoamine oxidase A Rattus norvegicus 25-30 9365932-1 1997 The interactions of catecholamines with alpha 1B-adrenergic receptors (alpha 1B-AR) located on the surface of many cell types are responsible for physiologic and pathologic functions in mammalian systems. Catecholamines 20-34 adrenoceptor alpha 1B Homo sapiens 40-69 9365932-1 1997 The interactions of catecholamines with alpha 1B-adrenergic receptors (alpha 1B-AR) located on the surface of many cell types are responsible for physiologic and pathologic functions in mammalian systems. Catecholamines 20-34 adrenoceptor alpha 1B Homo sapiens 71-82 9402032-2 1997 PACAP-27 induced the release of 4-15% of the total cellular catecholamines over 7 min, with an EC50 of 20 nM and the effect approaching maximum at 100 nM. Catecholamines 60-74 adenylate cyclase activating polypeptide 1 Bos taurus 0-5 9402032-5 1997 In contrast, (+/-)-BayK-8644, which prolongs the opening of L-type calcium channels produced a concentration-dependent increase in PACAP-27-induced catecholamine release with 1 microM increasing release by 40-60%. Catecholamines 148-161 adenylate cyclase activating polypeptide 1 Bos taurus 131-136 9402032-11 1997 When nitrendipine was used together with omega-conotoxin GVIA, omega-agatoxin IVA and omega-conotoxin MVIIC, catecholamine release induced by 20 nM or 100 nM PACAP-27 was reduced by 70-85%. Catecholamines 109-122 adenylate cyclase activating polypeptide 1 Bos taurus 158-163 9351345-3 1997 nNOS is expressed in orthosympathetic nerve terminals and regulates the release of catecholamines in the heart. Catecholamines 83-97 nitric oxide synthase 1 Homo sapiens 0-4 9402032-12 1997 Taken together these results suggest that influx of calcium through multiple different voltage-sensitive calcium channels mediate PACAP-27-induced catecholamine release from bovine chromaffin cells, and that L-, N- and Q-channels contribute to this response. Catecholamines 147-160 adenylate cyclase activating polypeptide 1 Bos taurus 130-135 10684471-9 1997 CONCLUSIONS: The results demonstrate that inhibition of the cardiac adenosine A(2) receptor, unmasks an adenosine A(1) receptor profibrillatory effect that is dependent upon endogenous cardiac catecholamines and beta-adrenoreceptor activation during myocardial hypoxia-reoxygenation. Catecholamines 193-207 adenosine receptor A1 Oryctolagus cuniculus 104-127 9353587-5 1997 Functional studies demonstrated that vincristine, tubulozole, podophyllotoxin, and demecolcine inhibited nAChR-stimulated catecholamine release noncompetitively and in a concentration-dependent manner, with IC50 values of 3 (1-10), 5 (2-10), 8 (4-15), and 19 (9-39) microM, respectively. Catecholamines 122-135 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 105-110 9414038-5 1997 As PACAP is localized in the noradrenaline secreting cells of the adrenal chromaffin cells, and stimulates catecholamine release, the present results suggest that PACAP may serve as a paracrine or autocrine regulatory factor for the chromaffin cells through PACAP-R. Catecholamines 107-120 adenylate cyclase activating polypeptide 1 Rattus norvegicus 3-8 9407393-0 1997 Pituitary adenylate cyclase activating polypeptide (PACAP) regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells. Catecholamines 83-96 adenylate cyclase activating polypeptide 1 Bos taurus 0-50 9407393-0 1997 Pituitary adenylate cyclase activating polypeptide (PACAP) regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells. Catecholamines 83-96 adenylate cyclase activating polypeptide 1 Bos taurus 52-57 9407393-2 1997 PACAP potently (in nanomolar concentrations) increases the amount of mRNA for each of the three catecholamine biosynthetic enzymes. Catecholamines 96-109 adenylate cyclase activating polypeptide 1 Bos taurus 0-5 9407393-8 1997 Thus, although PACAP is an effective regulator for expression of all three catecholamine enzyme genes, its mechanism of action on PNMT mRNA appears to be distinctive from its effects on TH and DBH gene transcription. Catecholamines 75-88 adenylate cyclase activating polypeptide 1 Bos taurus 15-20 9414038-5 1997 As PACAP is localized in the noradrenaline secreting cells of the adrenal chromaffin cells, and stimulates catecholamine release, the present results suggest that PACAP may serve as a paracrine or autocrine regulatory factor for the chromaffin cells through PACAP-R. Catecholamines 107-120 adenylate cyclase activating polypeptide 1 Rattus norvegicus 163-168 9326274-0 1997 Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters. Catecholamines 14-28 catechol-O-methyltransferase Homo sapiens 32-60 9326274-1 1997 To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3H-substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast, and HEK293 cells) that had been transfected with the recombinant human transporters. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 16-44 9326274-1 1997 To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3H-substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast, and HEK293 cells) that had been transfected with the recombinant human transporters. Catecholamines 64-78 catechol-O-methyltransferase Homo sapiens 46-50 9350634-12 1997 In response to insulin infusion, catecholamines increased on day 2 (noradrenaline and adrenaline) and day 7 (adrenaline), but not at sea level. Catecholamines 33-47 insulin Homo sapiens 15-22 9372267-2 1997 Exposure of lymphocytes to catecholamines at concentrations as low as 10 nM leads to decreased proliferation and differentiation, e.g. interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immunoglobulin (Ig). Catecholamines 27-41 interferon gamma Homo sapiens 135-151 9396226-3 1997 We studied the effects of nicotine-administration (5 mg/kg x 2/day, 7 days) on immunoreactivity for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, in the rat forebrain including the cerebral cortex, hippocampus, striatum and hypothalamus to investigate the influence on catecholaminergic neurons. Catecholamines 155-168 tyrosine hydroxylase Rattus norvegicus 100-120 9396226-3 1997 We studied the effects of nicotine-administration (5 mg/kg x 2/day, 7 days) on immunoreactivity for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, in the rat forebrain including the cerebral cortex, hippocampus, striatum and hypothalamus to investigate the influence on catecholaminergic neurons. Catecholamines 155-168 tyrosine hydroxylase Rattus norvegicus 122-124 9321797-3 1997 Reperfusion of catecholamine-depleted, [3H]inositol-labeled hearts in the presence of ET-1 caused an increase in [3H]inositol phosphates (7,073 +/- 1,004 to 17,300 +/- 206 counts.min-1.g tissue-1, means +/- SE, n = 4, P < 0.01), which was quantitatively greater than the release observed under normoxic conditions, but there was no increase in [3H]Ins(1,4,5)P3. Catecholamines 15-28 endothelin 1 Rattus norvegicus 86-90 9313925-4 1997 The catecholamines couple the alpha 2A-adrenoceptor to both an increase and a decrease in the rate of cyclic AMP production. Catecholamines 4-18 adrenoceptor alpha 2A Homo sapiens 30-51 9313925-17 1997 Since octopamine and synephrine occur naturally in, and are co-released with catecholamines from, mammalian tissues, the results of the present study suggest that the human cloned alpha 2A-adrenoceptor can be coupled selectively by different endogenous agonists to G-protein pathways mediating the regulation of adenylyl cyclase activity. Catecholamines 77-91 adrenoceptor alpha 2A Homo sapiens 180-201 9315384-9 1997 Tyrosine hydroxylase was detected in the RVLM and NTS and PNMT was also detected in the RVLM, which agrees with the distribution of catecholamine neurons in the medulla. Catecholamines 132-145 phenylethanolamine-N-methyltransferase Rattus norvegicus 58-62 9342538-8 1997 Insulin and glucocorticoids increase leptin expression, whereas catecholamines, via beta-adrenergic receptors and cAMP, and long-chain fatty acids (and thiazolidinediones), via PPARy, inhibit leptin expression. Catecholamines 64-78 insulin Homo sapiens 0-7 9342538-8 1997 Insulin and glucocorticoids increase leptin expression, whereas catecholamines, via beta-adrenergic receptors and cAMP, and long-chain fatty acids (and thiazolidinediones), via PPARy, inhibit leptin expression. Catecholamines 64-78 leptin Homo sapiens 192-198 9380436-3 1997 The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) catalyze the rate-limiting step in the catecholamine pathway and production of epinephrine, respectively. Catecholamines 127-140 phenylethanolamine-N-methyltransferase Rattus norvegicus 42-80 9380436-3 1997 The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) catalyze the rate-limiting step in the catecholamine pathway and production of epinephrine, respectively. Catecholamines 127-140 phenylethanolamine-N-methyltransferase Rattus norvegicus 82-86 9294131-5 1997 An antibody directed against this peptide blocked the inhibitory effect of chromogranin A proteolytic fragments on nicotinic-stimulated catecholamine secretion. Catecholamines 136-149 chromogranin A Bos taurus 75-89 9294131-7 1997 The inhibitory effect was specific for nicotinic cholinergic stimulation of catecholamine release, and was shared by this chromogranin A region from several species. Catecholamines 76-89 chromogranin A Bos taurus 122-136 9294131-10 1997 This small domain within chromogranin A may contribute to a novel, autocrine, homeostatic (negative-feedback) mechanism controlling catecholamine release from chromaffin cells and neurons. Catecholamines 132-145 chromogranin A Bos taurus 25-39 9332722-1 1997 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the formation of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis. Catecholamines 115-128 GTP cyclohydrolase 1 Rattus norvegicus 0-20 9332722-1 1997 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the formation of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis. Catecholamines 115-128 GTP cyclohydrolase 1 Rattus norvegicus 22-27 9372267-2 1997 Exposure of lymphocytes to catecholamines at concentrations as low as 10 nM leads to decreased proliferation and differentiation, e.g. interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immunoglobulin (Ig). Catecholamines 27-41 interferon gamma Homo sapiens 153-162 9372267-2 1997 Exposure of lymphocytes to catecholamines at concentrations as low as 10 nM leads to decreased proliferation and differentiation, e.g. interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immunoglobulin (Ig). Catecholamines 27-41 interleukin 4 Homo sapiens 165-178 9372267-2 1997 Exposure of lymphocytes to catecholamines at concentrations as low as 10 nM leads to decreased proliferation and differentiation, e.g. interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immunoglobulin (Ig). Catecholamines 27-41 interleukin 4 Homo sapiens 180-184 9372267-4 1997 The catecholamine-dependent inhibition of T- and B-lymphocyte activity is mediated via an induction of a Bcl-2/Bax and Fas/FasL involved apoptosis. Catecholamines 4-17 BCL2 apoptosis regulator Homo sapiens 105-110 9372267-4 1997 The catecholamine-dependent inhibition of T- and B-lymphocyte activity is mediated via an induction of a Bcl-2/Bax and Fas/FasL involved apoptosis. Catecholamines 4-17 BCL2 associated X, apoptosis regulator Homo sapiens 111-114 9372267-4 1997 The catecholamine-dependent inhibition of T- and B-lymphocyte activity is mediated via an induction of a Bcl-2/Bax and Fas/FasL involved apoptosis. Catecholamines 4-17 Fas ligand Homo sapiens 123-127 9291152-4 1997 For example, mRNA for tyrosine hydroxylase, the rate-limiting enzyme for catecholamine synthesis, was detected as early as stage 10a, late GD 8, before the neural crest cells appear (stage 12, mid GD 10). Catecholamines 73-86 tyrosine hydroxylase Rattus norvegicus 22-42 9309516-1 1997 Aromatic L-amino acid decarboxylase deficiency is an inborn error of metabolism that leads to combined serotonin and catecholamine deficiency, first described by Hyland et al in 1990. Catecholamines 117-130 dopa decarboxylase Homo sapiens 0-35 9276735-2 1997 We previously showed that the physiologic nicotinic cholinergic signal for secretion also activates the biosynthesis of chromogranin A, the major protein released with catecholamines. Catecholamines 168-182 chromogranin A Homo sapiens 120-134 9378433-1 1997 Acute therapy with catecholamines--long-term therapy with ACE inhibitor-loop diuretic combination]. Catecholamines 19-33 angiotensin I converting enzyme Homo sapiens 58-61 9283721-0 1997 Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Catecholamines 0-13 dopamine beta-hydroxylase Canis lupus familiaris 106-131 9258252-7 1997 We conclude that enhancement of IL-8 production is one of the pathways via which beta 2-adrenergic agonists such as catecholamines can influence inflammatory responses. Catecholamines 116-130 C-X-C motif chemokine ligand 8 Homo sapiens 32-36 9235905-1 1997 Expression of tyrosine hydroxylase (TH) is limited to catecholamine-producing neurons and neuroendocrine cells in a cell type-specific manner and is inducible by the cAMP-regulated signaling pathway. Catecholamines 54-67 tyrosine hydroxylase Rattus norvegicus 14-34 9235905-1 1997 Expression of tyrosine hydroxylase (TH) is limited to catecholamine-producing neurons and neuroendocrine cells in a cell type-specific manner and is inducible by the cAMP-regulated signaling pathway. Catecholamines 54-67 tyrosine hydroxylase Rattus norvegicus 36-38 9288945-6 1997 However, maximal cAMP accumulation was significantly reduced in response to various beta3-adrenergic agonists, including endogenous catecholamines, (-)-epinephrine and (-)-norepinephrine, the non-selective agonist (-)-isoproterenol, and the beta3-adrenergic selective agonist CGP 12177A. Catecholamines 132-146 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 84-89 9288945-6 1997 However, maximal cAMP accumulation was significantly reduced in response to various beta3-adrenergic agonists, including endogenous catecholamines, (-)-epinephrine and (-)-norepinephrine, the non-selective agonist (-)-isoproterenol, and the beta3-adrenergic selective agonist CGP 12177A. Catecholamines 132-146 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 241-246 9280203-12 1997 Several hormones such as angiotensin II, ANP and catecholamines, the levels of which are increased in hypertension, downregulate or upregulate ANP-C receptors and ANP-C receptor-mediated inhibition of adenylyl cyclase. Catecholamines 49-63 natriuretic peptide A Homo sapiens 143-146 9280203-12 1997 Several hormones such as angiotensin II, ANP and catecholamines, the levels of which are increased in hypertension, downregulate or upregulate ANP-C receptors and ANP-C receptor-mediated inhibition of adenylyl cyclase. Catecholamines 49-63 natriuretic peptide receptor 3 Homo sapiens 143-148 9262345-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that plays an important role in the inactivation of catecholamine neurotransmitters. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 0-28 9262345-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that plays an important role in the inactivation of catecholamine neurotransmitters. Catecholamines 101-114 catechol-O-methyltransferase Rattus norvegicus 30-34 9258252-7 1997 We conclude that enhancement of IL-8 production is one of the pathways via which beta 2-adrenergic agonists such as catecholamines can influence inflammatory responses. Catecholamines 116-130 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 81-87 9284402-1 1997 Almost all the genes of the enzymes which synthesize and metabolize the catecholamines (dopamine, norepinephrine, epinephrine) have been cloned and the gene targeting technology have been applied to introduce the gene knockout mouse such as thyrosine hydroxylase and dopamine beta hydroxylase. Catecholamines 72-86 dopamine beta hydroxylase Mus musculus 267-292 9204909-7 1997 In dually labeled tissue, peroxidase reaction product for the catecholamine-synthesizing enzyme tyrosine hydroxylase is present in DAT-immunoreactive profiles. Catecholamines 62-75 solute carrier family 6 member 3 Rattus norvegicus 131-134 9272507-11 1997 Conversely, LQT2 patients are at higher risk to develop syncope under stressful conditions, because of the combined arrhythmogenic effect of catecholamines with the insufficient adaptation of their QT interval. Catecholamines 141-155 potassium voltage-gated channel subfamily H member 2 Homo sapiens 12-16 9247147-7 1997 When the expression of IL-6 was studied at the protein level, the stimulation of IL-6 gene via beta3-receptors resulted in secretion of IL-6 up to the concentration 10 ng/ml culture media in 24 h. The results indicate a new type of regulation of expression of IL-1alpha and IL-6 genes in brown adipocytes by catecholamines acting via beta3-adrenergic receptors. Catecholamines 308-322 interleukin 6 Mus musculus 23-27 9247147-7 1997 When the expression of IL-6 was studied at the protein level, the stimulation of IL-6 gene via beta3-receptors resulted in secretion of IL-6 up to the concentration 10 ng/ml culture media in 24 h. The results indicate a new type of regulation of expression of IL-1alpha and IL-6 genes in brown adipocytes by catecholamines acting via beta3-adrenergic receptors. Catecholamines 308-322 interleukin 6 Mus musculus 81-85 9247147-7 1997 When the expression of IL-6 was studied at the protein level, the stimulation of IL-6 gene via beta3-receptors resulted in secretion of IL-6 up to the concentration 10 ng/ml culture media in 24 h. The results indicate a new type of regulation of expression of IL-1alpha and IL-6 genes in brown adipocytes by catecholamines acting via beta3-adrenergic receptors. Catecholamines 308-322 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 95-100 9247147-7 1997 When the expression of IL-6 was studied at the protein level, the stimulation of IL-6 gene via beta3-receptors resulted in secretion of IL-6 up to the concentration 10 ng/ml culture media in 24 h. The results indicate a new type of regulation of expression of IL-1alpha and IL-6 genes in brown adipocytes by catecholamines acting via beta3-adrenergic receptors. Catecholamines 308-322 interleukin 6 Mus musculus 81-85 9247147-7 1997 When the expression of IL-6 was studied at the protein level, the stimulation of IL-6 gene via beta3-receptors resulted in secretion of IL-6 up to the concentration 10 ng/ml culture media in 24 h. The results indicate a new type of regulation of expression of IL-1alpha and IL-6 genes in brown adipocytes by catecholamines acting via beta3-adrenergic receptors. Catecholamines 308-322 interleukin 1 alpha Mus musculus 260-269 9247147-7 1997 When the expression of IL-6 was studied at the protein level, the stimulation of IL-6 gene via beta3-receptors resulted in secretion of IL-6 up to the concentration 10 ng/ml culture media in 24 h. The results indicate a new type of regulation of expression of IL-1alpha and IL-6 genes in brown adipocytes by catecholamines acting via beta3-adrenergic receptors. Catecholamines 308-322 interleukin 6 Mus musculus 81-85 9247147-7 1997 When the expression of IL-6 was studied at the protein level, the stimulation of IL-6 gene via beta3-receptors resulted in secretion of IL-6 up to the concentration 10 ng/ml culture media in 24 h. The results indicate a new type of regulation of expression of IL-1alpha and IL-6 genes in brown adipocytes by catecholamines acting via beta3-adrenergic receptors. Catecholamines 308-322 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 334-339 9237635-8 1997 These dynamic processes appear concomitantly with the phosphorylation of annexin 2 in this compartment and with catecholamine release. Catecholamines 112-125 annexin A2 Homo sapiens 73-82 9309797-1 1997 Molecular modeling studies have predicted that the beta-hydroxyl group of the catecholamines interacts with the beta 2-adrenoceptor at the serine residue at position 165 (Ser165) located on transmembrane helix IV; however, this has not been confirmed by site-directed mutagenesis. Catecholamines 78-92 adrenoceptor beta 2 Homo sapiens 112-131 9309797-2 1997 It has been inferred that this site, which is conserved in all of the nine known alpha- and beta-adrenoceptor subtypes, is also involved in the interaction of catecholamines with the alpha 2a-adrenoceptor. Catecholamines 159-173 adrenoceptor alpha 2A Homo sapiens 183-204 9309797-3 1997 To test the hypothesis that the beta-hydroxyl group of the catecholamines interacts with Ser165 of the alpha 2a-adrenoceptor, we prepared a mutant alpha 2a-adrenoceptor where Ser165 was mutated to alanine. Catecholamines 59-73 adrenoceptor alpha 2A Homo sapiens 103-124 9309797-3 1997 To test the hypothesis that the beta-hydroxyl group of the catecholamines interacts with Ser165 of the alpha 2a-adrenoceptor, we prepared a mutant alpha 2a-adrenoceptor where Ser165 was mutated to alanine. Catecholamines 59-73 adrenoceptor alpha 2A Homo sapiens 147-168 9309797-5 1997 We have previously shown that mutation of Ser90, located in transmembrane helix II, to either alanine or cysteine produces a selective reduction in the affinity of the (-)-enantiomers of the catecholamines for the alpha 2a-adrenoceptor, with no effect on the (+)-enantiomers or the corresponding beta-desoxy analogs. Catecholamines 191-205 adrenoceptor alpha 2A Homo sapiens 214-235 9309797-6 1997 This is consistent with the known stereoselectivity involved in the interactions of catecholamines with the alpha 2a-adrenoceptor. Catecholamines 84-98 adrenoceptor alpha 2A Homo sapiens 108-129 9309797-8 1997 Because all known alpha-adrenoceptor subtypes have a serine residue at a position corresponding to Ser90 of the alpha 2a-adrenoceptor, it would appear that this site represents an important point for attachment of the beta-hydroxyl group of catecholamines. Catecholamines 241-255 adrenoceptor alpha 2A Homo sapiens 112-133 9218708-7 1997 Substance P inhibited the epibatidine-evoked catecholamine release from both fractions by up to 85% (IC50 = 3-5 microM). Catecholamines 45-58 tachykinin precursor 1 Bos taurus 0-11 9194512-6 1997 The hemodynamic actions of hBNP suggest clinical utility for the management of acute hypertension associated with numerous surgical procedures, a condition linked to catecholamine activation. Catecholamines 166-179 natriuretic peptide B Homo sapiens 27-31 9200738-0 1997 Long-lasting effect of catecholamine deficiency on differentiating vasopressin and oxytocin neurons in the rat supraoptic nucleus. Catecholamines 23-36 arginine vasopressin Rattus norvegicus 67-78 9200738-1 1997 According to our earlier study, the catecholamine depletion in neonatal rats resulted in stimulation of the vasopressin and oxytocin gene expression in the neurons of the supraoptic nucleus. Catecholamines 36-49 arginine vasopressin Rattus norvegicus 108-119 9200738-2 1997 The present study extends this line, evaluating whether the catecholamine deficiency provides a long-lasting effect on the differentiating vasopressin and oxytocin neurons of the supraoptic nucleus. Catecholamines 60-73 arginine vasopressin Rattus norvegicus 139-150 9200738-7 1997 Conversely, the catecholamine deficiency resulted in an increased content of the vasopressin-immunoreactive material in cell bodies and processes. Catecholamines 16-29 arginine vasopressin Rattus norvegicus 81-92 9200738-10 1997 Thus, the catecholamine deficiency in the course of the neuron differentiation resulted in a long-lasting augmentation of the intracellular content of vasopressin and oxytocin but did not influence the vasopressin and oxytocin gene expression. Catecholamines 10-23 arginine vasopressin Rattus norvegicus 151-162 9184658-3 1997 In this study we demonstrate that CDV replication in the substantia nigra induces an early decrease in transcript level of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 178-191 tyrosine hydroxylase Mus musculus 123-143 9166692-5 1997 Mating with intromission significantly augmented the percentage of TH-immunoreactive (TH-IR) neurons colabeled with nuclear Fos-like immunoreactivity (Fos-IR) in both the A6 and the rostral A2 midbrain catecholamine cell groups in females, but not males. Catecholamines 202-215 proto-oncogene c-Fos Mustela putorius furo 151-154 9187779-11 1997 Intrathecal Fentanyl (ITF) is also capable of reducing maternal plasma epinephrine concentration, thus avoiding the possibly deleterious side effects of excess amounts of this catecholamine during labour. Catecholamines 176-189 trefoil factor 3 Homo sapiens 22-25 9166715-4 1997 This reduction in catecholamines at 20 microM was probably due to changes in the phosphorylation state of TH, as its enzymatic activity was found to be decreased to 66 and 69% in 48 and 72 h, respectively. Catecholamines 18-32 tyrosine hydroxylase Bos taurus 106-108 9330018-4 1997 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters and is a candidate for involvement in bipolar disorder. Catecholamines 86-99 catechol-O-methyltransferase Homo sapiens 11-39 9330018-4 1997 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters and is a candidate for involvement in bipolar disorder. Catecholamines 86-99 catechol-O-methyltransferase Homo sapiens 41-45 9151720-7 1997 In dually labeled tissue, peroxidase reaction product for the catecholamine-synthesizing enzyme tyrosine hydroxylase is present in DAT-immunoreactive profiles. Catecholamines 62-75 solute carrier family 6 member 3 Rattus norvegicus 131-134 9131778-3 1997 We used ultrastructural immunocytochemistry in this region to show that immunogold labeling for VMAT2 is present in varicose axonal processes, many of which also contain the catecholamine-synthesizing enzyme tyrosine-hydroxylase. Catecholamines 174-187 solute carrier family 18 member A2 Rattus norvegicus 96-101 9153661-5 1997 Therefore, we compared immunoreactivity for the catecholamine-synthesizing enzyme dopamine beta-hydroxylase, for neuropeptide Y and for substance P in the intermediate gray matter of the spinal cord in control rats and in rats seven or fourteen days after transection at the fourth thoracic cord segment. Catecholamines 48-61 dopamine beta-hydroxylase Rattus norvegicus 82-107 9164836-5 1997 Glutathione conjugation of these quinones is a detoxication reaction that prevents redox cycling, thus indicating that GSTs have a cytoprotective role involving elimination of reactive chemical species originating from the oxidative metabolism of catecholamines. Catecholamines 247-261 hematopoietic prostaglandin D synthase Homo sapiens 119-123 9194572-0 1997 Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney. Catecholamines 0-14 ornithine decarboxylase, structural 1 Mus musculus 49-52 9194572-1 1997 Catecholamine depletion, evoked by reserpine, dramatically impaired (5-fold) the testosterone-induced increase of ornithine decarboxylase (ODC) activity in female mouse kidney. Catecholamines 0-13 ornithine decarboxylase, structural 1 Mus musculus 114-137 9194572-1 1997 Catecholamine depletion, evoked by reserpine, dramatically impaired (5-fold) the testosterone-induced increase of ornithine decarboxylase (ODC) activity in female mouse kidney. Catecholamines 0-13 ornithine decarboxylase, structural 1 Mus musculus 139-142 9194572-5 1997 Northern blot analysis revealed that the ODC mRNA level, that was increased 10-fold by testosterone, was decreased 2-fold in catecholamine-depleted hypertrophic kidney. Catecholamines 125-138 ornithine decarboxylase, structural 1 Mus musculus 41-44 9194572-8 1997 It is concluded that catecholamines could be involved together with testosterone in regulation of the ODC gene expression in mouse kidney. Catecholamines 21-35 ornithine decarboxylase, structural 1 Mus musculus 102-105 9176257-0 1997 Chronic effects of catecholamines on the beta 2-adrenoreceptor system in cultured human airway epithelial cells. Catecholamines 19-33 adrenoceptor beta 2 Homo sapiens 41-62 9176354-0 1997 Canine adrenal catecholamine response to VIP is blocked by PACAP-(6-27) in vivo. Catecholamines 15-28 vasoactive intestinal peptide Canis lupus familiaris 41-44 9176354-1 1997 The goal of the present study was to characterize the adrenal catecholamine response to exogenous vasoactive intestinal peptide (VIP) in anesthetized dogs. Catecholamines 62-75 vasoactive intestinal peptide Canis lupus familiaris 129-132 9176354-6 1997 In the control group, VIP produced a significant increase in adrenal catecholamine output. Catecholamines 69-82 vasoactive intestinal peptide Canis lupus familiaris 22-25 9176354-8 1997 In the presence of PACAP-(6-27), however, the catecholamine response to VIP was attenuated by approximately 77% (P < 0.05). Catecholamines 46-59 vasoactive intestinal peptide Canis lupus familiaris 72-75 9176354-9 1997 The present study suggests that adrenal catecholamine secretion induced by exogenous VIP may be mediated by a PACAP-related mechanism, most probably through a PACAP type I receptor, in anesthetized dogs. Catecholamines 40-53 vasoactive intestinal peptide Canis lupus familiaris 85-88 9176207-6 1997 These findings provide the first evidence for a gastric beta 3-AR mediating catecholamine stimulation of gastrin and somatostatin releases from antral cells. Catecholamines 76-89 adrenoceptor beta 3 Rattus norvegicus 56-65 9176207-6 1997 These findings provide the first evidence for a gastric beta 3-AR mediating catecholamine stimulation of gastrin and somatostatin releases from antral cells. Catecholamines 76-89 gastrin Rattus norvegicus 105-112 9176207-6 1997 These findings provide the first evidence for a gastric beta 3-AR mediating catecholamine stimulation of gastrin and somatostatin releases from antral cells. Catecholamines 76-89 somatostatin Rattus norvegicus 117-129 9082970-7 1997 ET-1 induces a marked rise in catecholamine release by fragments of the adrenal medulla, and both BQ-123 and BQ-788 partially reverse this effect. Catecholamines 30-43 endothelin 1 Rattus norvegicus 0-4 9082970-9 1997 Thus, in the rat, the corticosteroid secretagogue effect of ETs seems to be exclusively mediated by the ETB receptor subtype, and the catecholamine secretagogue action by both ETA and ETB. Catecholamines 134-147 endothelin receptor type B Rattus norvegicus 184-187 9082970-8 1997 ET-3 and BQ-3020 elicit a catecholamine release that is less intense than that produced by ET-1; this response is unaffected by BQ-123 and abolished by BQ-788. Catecholamines 26-39 endothelin 3 Rattus norvegicus 0-4 9144319-0 1997 Deprivation of Na+, Ca2+ and Mg2+ from the extracellular solution increases cytosolic Ca2+ and stimulates catecholamine secretion from cultured bovine adrenal chromaffin cells. Catecholamines 106-119 carbonic anhydrase 2 Bos taurus 20-23 9112388-5 1997 Using this culture condition, we examined the effects of not only CRH but also other secretagogues such as catecholamines, vasopressin, and angiotensin II, upon the transcriptional activity of the POMC gene. Catecholamines 107-121 pro-opiomelanocortin-alpha Mus musculus 197-201 9112388-9 1997 Our results suggest that 1) catecholamines, as well as CRH, positively regulate the POMC gene at physiological concentrations; 2) the cAMP-PKA system is the common intracellular signaling pathway for CRH and catecholamines; and 3) vasopressin and angiotensin II also have weak but significant stimulatory effects on POMC promoter activity. Catecholamines 28-42 pro-opiomelanocortin-alpha Mus musculus 84-88 9112388-9 1997 Our results suggest that 1) catecholamines, as well as CRH, positively regulate the POMC gene at physiological concentrations; 2) the cAMP-PKA system is the common intracellular signaling pathway for CRH and catecholamines; and 3) vasopressin and angiotensin II also have weak but significant stimulatory effects on POMC promoter activity. Catecholamines 28-42 corticotropin releasing hormone Mus musculus 200-203 9112388-9 1997 Our results suggest that 1) catecholamines, as well as CRH, positively regulate the POMC gene at physiological concentrations; 2) the cAMP-PKA system is the common intracellular signaling pathway for CRH and catecholamines; and 3) vasopressin and angiotensin II also have weak but significant stimulatory effects on POMC promoter activity. Catecholamines 28-42 pro-opiomelanocortin-alpha Mus musculus 316-320 9112388-9 1997 Our results suggest that 1) catecholamines, as well as CRH, positively regulate the POMC gene at physiological concentrations; 2) the cAMP-PKA system is the common intracellular signaling pathway for CRH and catecholamines; and 3) vasopressin and angiotensin II also have weak but significant stimulatory effects on POMC promoter activity. Catecholamines 208-222 corticotropin releasing hormone Mus musculus 55-58 9112388-9 1997 Our results suggest that 1) catecholamines, as well as CRH, positively regulate the POMC gene at physiological concentrations; 2) the cAMP-PKA system is the common intracellular signaling pathway for CRH and catecholamines; and 3) vasopressin and angiotensin II also have weak but significant stimulatory effects on POMC promoter activity. Catecholamines 208-222 pro-opiomelanocortin-alpha Mus musculus 84-88 9144319-1 1997 We report here that exposing cultured chromaffin cells to a low ionic strength medium (with sucrose in place of NaCl to maintain osmolarity) can induce a marked elevation in cytosolic Ca2+ concentration ([Ca2+]i) and catecholamine (CA) release. Catecholamines 217-230 carbonic anhydrase 2 Bos taurus 184-187 9175046-14 1997 In hypotensive patients, plasma adrenaline levels were even higher; the increased plasma catecholamine levels induced an alpha 2- and beta 2-adrenoceptor downregulation. Catecholamines 89-102 adrenoceptor beta 2 Homo sapiens 121-153 9144319-1 1997 We report here that exposing cultured chromaffin cells to a low ionic strength medium (with sucrose in place of NaCl to maintain osmolarity) can induce a marked elevation in cytosolic Ca2+ concentration ([Ca2+]i) and catecholamine (CA) release. Catecholamines 217-230 carbonic anhydrase 2 Bos taurus 205-208 9787239-1 1997 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis. Catecholamines 118-131 GTP cyclohydrolase 1 Rattus norvegicus 0-20 9787239-1 1997 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the cofactor for catecholamine, indolamine and nitric oxide biosynthesis. Catecholamines 118-131 GTP cyclohydrolase 1 Rattus norvegicus 22-27 9092590-12 1997 fET-mediated transport of catecholamines is sensitive to cocaine and tricyclic antidepressants, with antagonist potencies significantly correlated with hNET inhibitor sensitivity. Catecholamines 26-40 solute carrier family 6 member 2 Homo sapiens 152-156 9163324-1 1997 The beta3-adrenergic receptor (beta3-AR) exerts a central role in the transduction of catecholamine effects in white and brown adipose tissue (WAT and BAT). Catecholamines 86-99 adrenoceptor beta 3 Rattus norvegicus 4-29 9163324-1 1997 The beta3-adrenergic receptor (beta3-AR) exerts a central role in the transduction of catecholamine effects in white and brown adipose tissue (WAT and BAT). Catecholamines 86-99 adrenoceptor beta 3 Rattus norvegicus 31-39 9096880-12 1997 activin-A treatment on neurons that manufacture corticotropin-releasing factor, and consequently on circulating catecholamine concentrations, may have increased testicular activity independently of changes in pituitary function. Catecholamines 112-125 inhibin subunit beta A Rattus norvegicus 0-9 9140020-1 1997 This study was designed to determine if the increase in plasma renin activity (PRA) that occurs during water deprivation is mediated by the renal sympathetic nerves or adrenomedullary catecholamine release. Catecholamines 184-197 renin Rattus norvegicus 63-68 9140032-0 1997 Role of ET(A) and ET(B) receptors in endothelin-1-induced adrenal catecholamine secretion in vivo. Catecholamines 66-79 endothelin receptor type A Canis lupus familiaris 8-13 9140032-0 1997 Role of ET(A) and ET(B) receptors in endothelin-1-induced adrenal catecholamine secretion in vivo. Catecholamines 66-79 endothelin 1 Canis lupus familiaris 37-49 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Catecholamines 220-233 fibroblast growth factor 1 Homo sapiens 71-102 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Catecholamines 220-233 fibroblast growth factor 1 Homo sapiens 104-108 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Catecholamines 220-233 tyrosine hydroxylase Homo sapiens 254-274 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Catecholamines 220-233 tyrosine hydroxylase Homo sapiens 276-278 9172156-1 1997 Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons. Catecholamines 220-233 tyrosine hydroxylase Homo sapiens 287-289 9084894-0 1997 Is the polymorphic microsatellite repeat of the dopamine beta-hydroxylase gene associated with biochemical variability of the catecholamine pathway in schizophrenia? Catecholamines 126-139 dopamine beta-hydroxylase Homo sapiens 48-73 9084894-5 1997 These results suggest that genotypic polymorphism of the human DBH is likely to be associated with biochemical variability of the catecholamine pathway in schizophrenia. Catecholamines 130-143 dopamine beta-hydroxylase Homo sapiens 63-66 9144094-8 1997 In contrast, catecholamine-induced lipolysis is markedly increased in omental as compared to subcutaneous adipocytes in obese males, mainly due to an increase in beta(3)-adrenoceptor function of visceral fat cells, in combination with a smaller increase in beta(1)-adrenoceptor function. Catecholamines 13-26 adrenoceptor beta 3 Homo sapiens 162-182 9100587-7 1997 The results indicate the existence of a marked impairment of catecholamine-induced lipolysis in nonobese PCOS women displaying early features of the insulin resistance syndrome due to multiple lipolysis defects as a lower beta 2-adrenoceptor density and reduced function of the protein kinase, hormone-sensitive lipase complex. Catecholamines 61-74 adrenoceptor beta 2 Homo sapiens 222-241 9105685-3 1997 The oxidation of the catecholamine to a quinone is greatly accelerated by the enzyme tyrosinase. Catecholamines 21-34 tyrosinase Homo sapiens 85-95 9137906-5 1997 As DDC is an enzyme specifically involved in catecholamine synthesis, insular cells must possess the capacity to elaborate this class of hormone at least up to the dopamine-decarboxylation step. Catecholamines 45-58 dopa decarboxylase Rattus norvegicus 3-6 9084446-1 1997 Annexin 2 phosphorylated in vitro by protein kinase C has been shown to restore partially catecholamine secretion in streptolysin O-permeabilized chromaffin cells depleted of their protein kinase C activity. Catecholamines 90-103 annexin A2 Homo sapiens 0-9 9144094-8 1997 In contrast, catecholamine-induced lipolysis is markedly increased in omental as compared to subcutaneous adipocytes in obese males, mainly due to an increase in beta(3)-adrenoceptor function of visceral fat cells, in combination with a smaller increase in beta(1)-adrenoceptor function. Catecholamines 13-26 adrenoceptor beta 1 Homo sapiens 257-277 9089644-7 1997 These results provide evidence for an in vivo tissue-specific regulation of IR gene expression at the mRNA level in rats under an experimental condition of excess of catecholamines. Catecholamines 166-180 insulin receptor Rattus norvegicus 76-78 9119969-6 1997 These data demonstrate a specific effect of increasing levels of circulating catecholamines on beta2-adrenoceptors on NK cells. Catecholamines 77-91 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 95-100 15001085-1 1997 Chromaffin and PC12 cells were used to elucidate mechanisms of stimulation of gene expression of tyrosine hydroxylase (TH), the pivotal enzyme in catecholamine biosynthesis. Catecholamines 146-159 tyrosine hydroxylase Rattus norvegicus 97-117 9089629-1 1997 Growth hormone (GH) exerts acute insulin-like effects, such as increased lipogenesis and inhibition of catecholamine-induced lipolysis, in rat adipocytes that have not been exposed to GH during the preceding three hours. Catecholamines 103-116 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 9106627-1 1997 The beta1-adrenergic receptor (beta1-AR) mediates several functions of catecholamines in the heart, including the stimulation of heart rate and contractility. Catecholamines 71-85 adrenoceptor beta 1 Homo sapiens 4-29 9106627-1 1997 The beta1-adrenergic receptor (beta1-AR) mediates several functions of catecholamines in the heart, including the stimulation of heart rate and contractility. Catecholamines 71-85 adrenoceptor beta 1 Homo sapiens 31-39 9106629-1 1997 Previous studies have shown that a subpopulation of the catecholamine-degrading enzymes monoamine oxidase (MAO) A and B holds a previously unknown regulatory site, the I2-imidazoline binding site (I2BS). Catecholamines 56-69 amine oxidase [flavin-containing] A Oryctolagus cuniculus 88-119 15001085-1 1997 Chromaffin and PC12 cells were used to elucidate mechanisms of stimulation of gene expression of tyrosine hydroxylase (TH), the pivotal enzyme in catecholamine biosynthesis. Catecholamines 146-159 tyrosine hydroxylase Rattus norvegicus 119-121 15001086-3 1997 Catecholamine release is similar to other species although it gives robust secretion in response to stimuli such as muscarinic agonists, bradykinin or VIP. Catecholamines 0-13 vasoactive intestinal peptide Rattus norvegicus 151-154 9149442-3 1997 About 70% of catecholamine-synthesizing cells also exhibited immunoreactivity for phenylethanolamine-N-methyltransferase antiserum. Catecholamines 13-26 phenylethanolamine N-methyltransferase Gallus gallus 82-120 9089539-2 1997 The present study aimed to characterize the sympathetic fibres in the PLL by immuno-electronmicroscopy for tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis. Catecholamines 162-175 tyrosine hydroxylase Rattus norvegicus 107-127 9089539-2 1997 The present study aimed to characterize the sympathetic fibres in the PLL by immuno-electronmicroscopy for tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis. Catecholamines 162-175 tyrosine hydroxylase Rattus norvegicus 129-131 9138721-0 1997 Modulatory role of catecholamines in the transsynaptic expression of c-fos in the rat medial prefrontal cortex induced by disinhibition of the mediodorsal thalamus: a study employing microdialysis and immunohistochemistry. Catecholamines 19-33 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 69-74 9115981-1 1997 Involvement of SNAP-25 in the exocytosis of large dense-core vesicles in bovine adrenochromaffin cells was examined by measuring cleavage of SNAP-25 in relation to the levels of Ca2+-evoked catecholamine release from cells exposed to BoNT/A or /E, either before or after permeabilization. Catecholamines 190-203 synaptosome associated protein 25 Bos taurus 15-22 9124547-1 1997 An important facilitating effect of angiotensin II on adrenal catecholamine release has been demonstrated in several species. Catecholamines 62-75 angiotensinogen Homo sapiens 36-50 9118669-1 1997 OBJECTIVES: a) To investigate responsiveness to exogenous catecholamines in rat endotoxin shock by studying both myocardial and vascular functional parameters, and to determine the relationship of these parameters with other relevant biological parameters of the adrenergic pathway, such as myocardial beta-adrenergic receptors and cyclic adenosine monophosphate (cAMP); b) to investigate the role of tumor necrosis factor (TNF)-alpha via prophylactic anti-TNF-alpha monoclonal antibody administration. Catecholamines 58-72 tumor necrosis factor Rattus norvegicus 401-434 9118669-1 1997 OBJECTIVES: a) To investigate responsiveness to exogenous catecholamines in rat endotoxin shock by studying both myocardial and vascular functional parameters, and to determine the relationship of these parameters with other relevant biological parameters of the adrenergic pathway, such as myocardial beta-adrenergic receptors and cyclic adenosine monophosphate (cAMP); b) to investigate the role of tumor necrosis factor (TNF)-alpha via prophylactic anti-TNF-alpha monoclonal antibody administration. Catecholamines 58-72 tumor necrosis factor Rattus norvegicus 457-466 9138436-0 1997 The effect of decreased catecholamine transmission on ERP indices of selective attention. Catecholamines 24-37 ETS transcription factor ELK3 Homo sapiens 54-57 9138436-1 1997 This study examines the effect of decreased catecholamine transmission on event-related potential (ERP) indices of selective attention. Catecholamines 44-57 ETS transcription factor ELK3 Homo sapiens 74-97 9138436-1 1997 This study examines the effect of decreased catecholamine transmission on event-related potential (ERP) indices of selective attention. Catecholamines 44-57 ETS transcription factor ELK3 Homo sapiens 99-102 9089783-7 1997 Placental catecholamine clearance mediated via the placental NET may be important in the pathophysiology of disorders associated with placental dysfunction, impaired placental blood flow or intrauterine growth retardation. Catecholamines 10-23 solute carrier family 6 member 2 Homo sapiens 61-64 9054839-6 1997 Although vasopressin is a weak pressor in normal subjects, its administration at 0.04 U/min to 10 patients with septic shock who were receiving catecholamines increased arterial pressure (systolic/diastolic) from 92/52 to 146/66 mm Hg (P < .001/P < .05) due to peripheral vasoconstriction (systemic vascular resistance increased from 644 to 1187 dyne.s/cm5; P < .001). Catecholamines 144-158 arginine vasopressin Homo sapiens 9-20 9091339-2 1997 The 4-hydroxyestrogens are known to have both a strong estrogenic potency and affinity for catechol-O-methyltransferase (COMT), the enzyme that deactivates catecholamines. Catecholamines 156-170 catechol-O-methyltransferase Homo sapiens 91-119 9091339-2 1997 The 4-hydroxyestrogens are known to have both a strong estrogenic potency and affinity for catechol-O-methyltransferase (COMT), the enzyme that deactivates catecholamines. Catecholamines 156-170 catechol-O-methyltransferase Homo sapiens 121-125 9125763-8 1997 The second gene is an chromosome 9q34 (TSC-1) near the locus for dopamine-o-hydroxylase, an enzyme involved in the synthesis of catecholamine neurotransmitters. Catecholamines 128-141 TSC complex subunit 1 Homo sapiens 39-44 9138721-8 1997 The increase in the intensity of Fos-like immunostaining in strongly stimulated, catecholamine-depleted rats suggests that catecholamines modulate the degree to which thalamic activity can activate the PFC of awake animals. Catecholamines 81-94 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 33-36 9138721-8 1997 The increase in the intensity of Fos-like immunostaining in strongly stimulated, catecholamine-depleted rats suggests that catecholamines modulate the degree to which thalamic activity can activate the PFC of awake animals. Catecholamines 123-137 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 33-36 9065735-1 1997 A possible role of protein kinase C. Catecholamine release induced by angiotensin II, histamine, bradykinin and methacholine from the rat adrenal gland perfused in vitro was studied under conditions in which the activity of protein kinase C (PKC) was modified. Catecholamines 37-50 angiotensinogen Rattus norvegicus 70-84 9057138-8 1997 This study introduces novel results with regard to the regulation of the gene expression of AADC in PC12 cells, which is not paralleled by the other catecholamine biosynthetic enzymes. Catecholamines 149-162 dopa decarboxylase Rattus norvegicus 92-96 9075590-2 1997 Neuropeptide Y (NPY) is colocalized with catecholamines in central regions involved in blood pressure regulation and exerts depressor responses in the nucleus tractus solitarius (NTS). Catecholamines 41-55 neuropeptide Y Rattus norvegicus 0-14 9124332-12 1997 This induction of LPL gene expression may result from dynamic changes in serum catecholamines, plasma insulin, or events intrinsic to muscle contraction itself. Catecholamines 79-93 lipoprotein lipase Homo sapiens 18-21 9075590-2 1997 Neuropeptide Y (NPY) is colocalized with catecholamines in central regions involved in blood pressure regulation and exerts depressor responses in the nucleus tractus solitarius (NTS). Catecholamines 41-55 neuropeptide Y Rattus norvegicus 16-19 9003004-4 1997 The second aim was to examine the biological effect of exogenous CRH (and of its antagonist) on the production of catecholamines from these two types of cells. Catecholamines 114-128 corticotropin releasing hormone Rattus norvegicus 65-68 9042104-3 1997 Experimental evidence suggests that CRH may modulate the immune and inflammatory responses via two pathways: an antiinflammatory one operated by centrally released CRH, most likely through stimulation of glucocorticoid and catecholamine release, and one proinflammatory, through direct action of peripherally released CRH. Catecholamines 223-236 corticotropin releasing hormone Mus musculus 36-39 9013196-0 1997 Effects of thyrotropin-releasing hormone and its analogue, NS-3, on blood pressure, heart rate, and serum catecholamine levels in rats. Catecholamines 106-119 thyrotropin releasing hormone Rattus norvegicus 11-40 9013196-4 1997 The pressor and tachycardiac effects and increases in serum catecholamine levels caused by NS-3 were longer lasting, but not more potent than those caused by TRH. Catecholamines 60-73 mal, T-cell differentiation protein Rattus norvegicus 91-95 9027744-1 1997 Reduced oxygen tension (hypoxia) leads to increased stability of mRNA for tyrosine hydroxylase (TH), the rate limiting enzyme in biosynthesis of catecholamine neurotransmitters. Catecholamines 145-158 tyrosine hydroxylase Rattus norvegicus 74-94 9027734-1 1997 Gene expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated by reductions in oxygen tension (hypoxia). Catecholamines 75-88 tyrosine hydroxylase Rattus norvegicus 20-40 9027734-1 1997 Gene expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated by reductions in oxygen tension (hypoxia). Catecholamines 75-88 tyrosine hydroxylase Rattus norvegicus 42-44 9027744-1 1997 Reduced oxygen tension (hypoxia) leads to increased stability of mRNA for tyrosine hydroxylase (TH), the rate limiting enzyme in biosynthesis of catecholamine neurotransmitters. Catecholamines 145-158 tyrosine hydroxylase Rattus norvegicus 96-98 9013847-3 1997 Glucocorticoids enhance this synthesis and catecholamines hamper leptin production. Catecholamines 43-57 leptin Homo sapiens 65-71 8999889-9 1997 [3H]Norepinephrine and t-PA antigen were co-localized to the same subcellular fraction with a major peak at 1.4 M sucrose, consistent with the buoyant density of catecholamine storage vesicles. Catecholamines 162-175 plasminogen activator, tissue type Rattus norvegicus 23-27 9037496-1 1997 We recently described ultrastructural evidence for morphologically heterogeneous axon terminals containing the endogenous opioid peptide, methionine5-enkephalin (ENK), that formed synapses with neurons containing the catecholamine synthesizing enzyme, tyrosine hydroxylase, in the locus coeruleus (LC) of the rat brain. Catecholamines 217-230 proenkephalin Rattus norvegicus 138-160 9037496-1 1997 We recently described ultrastructural evidence for morphologically heterogeneous axon terminals containing the endogenous opioid peptide, methionine5-enkephalin (ENK), that formed synapses with neurons containing the catecholamine synthesizing enzyme, tyrosine hydroxylase, in the locus coeruleus (LC) of the rat brain. Catecholamines 217-230 proenkephalin Rattus norvegicus 162-165 8999889-1 1997 Catecholamine storage vesicles as a reservoir for the rapid release of t-PA. Catecholamines 0-13 plasminogen activator, tissue type Rattus norvegicus 71-75 8999889-5 1997 Therefore, we tested the hypothesis that t-PA is packaged in and released directly from catecholamine storage vesicles, using several chromaffin cell sources including the rat pheochromocytoma PC-12 chromaffin cell line, primary cultures of bovine adrenal chromaffin cells, and human pheochromocytoma. Catecholamines 88-101 plasminogen activator, tissue type Rattus norvegicus 41-45 8999889-10 1997 In addition, catecholamine storage vesicle lysates isolated from human pheochromocytoma tumors were enriched approximately 30-fold in t-PA antigen, compared with tumor homogenate. Catecholamines 13-26 plasminogen activator, tissue type Homo sapiens 134-138 8999889-11 1997 Furthermore, exposure of PC-12 cells or primary bovine adrenal chromaffin cells to chromaffin cell secretagogues (60 microM nicotine, 55 mM KCl, or 2 mM BaCl2) resulted in co-release of t-PA in parallel with catecholamines. Catecholamines 208-222 plasminogen activator, tissue type Bos taurus 186-190 8999889-12 1997 These data demonstrate that t-PA is expressed in chromaffin cells, is sorted into the regulated pathway of secretion, and is co-released with catecholamines by chromaffin cell stimulation. Catecholamines 142-156 plasminogen activator, tissue type Rattus norvegicus 28-32 8999889-13 1997 Catecholamine storage vesicles may be an important reservoir and sympathoadrenal activation an important physiologic mechanism for the rapid release of t-PA. Catecholamines 0-13 plasminogen activator, tissue type Rattus norvegicus 152-156 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 30-34 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Catecholamines 66-80 catechol-O-methyltransferase Homo sapiens 0-28 8988970-1 1997 OBJECTIVE: Catechol O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 11-39 9016331-1 1997 Trimetoquinol (TMQ, 1) is a unique catecholamine with a strong stereodependence for agonism at beta-adrenergic (S > > R) and antagonism at thromboxane A2/prostaglandin H2 (TP; R > > S) receptors. Catecholamines 35-48 ATPase H+ transporting V0 subunit a2 Homo sapiens 157-176 8988970-1 1997 OBJECTIVE: Catechol O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 41-45 8990146-4 1997 All three cell types in the composite tumor and all chromaffin cells in both nodular and nonnodular areas of the remaining medulla were strongly immunoreactive for tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis. Catecholamines 214-227 tyrosine hydroxylase Homo sapiens 164-184 9059216-1 1997 Dopamine is a naturally occurring catecholamine with actions in the central nervous system and endocrine systems, including inhibition of prolactin release from the pituitary gland. Catecholamines 34-47 prolactin Homo sapiens 138-147 9043712-1 1997 HPLC and Palkovits" microdissection technique were used to measure activities of two catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH) and dopa decarboxylase (DD), in the medial preoptic area (MPA) and arcuate nucleus (AN), both of which are involved in LH regulation. Catecholamines 85-98 tyrosine hydroxylase Rattus norvegicus 121-141 9043712-1 1997 HPLC and Palkovits" microdissection technique were used to measure activities of two catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH) and dopa decarboxylase (DD), in the medial preoptic area (MPA) and arcuate nucleus (AN), both of which are involved in LH regulation. Catecholamines 85-98 tyrosine hydroxylase Rattus norvegicus 143-145 9043712-1 1997 HPLC and Palkovits" microdissection technique were used to measure activities of two catecholamine-synthesizing enzymes, tyrosine hydroxylase (TH) and dopa decarboxylase (DD), in the medial preoptic area (MPA) and arcuate nucleus (AN), both of which are involved in LH regulation. Catecholamines 85-98 dopa decarboxylase Rattus norvegicus 151-169 9429845-6 1997 We argue that the beneficial effects are, at least in part, related to a reduction in the direct toxic effects of angiotensin II and catecholamines on cardiomyocytes resulting from the long term excess stimulation of the renin-angiotensin and sympathetic systems in these patients. Catecholamines 133-147 renin Homo sapiens 221-226 10728198-1 1997 Aromatic L-amino acid decarboxylase (AADC) deficiency results in an impaired synthesis of catecholamines and serotonin, and has been reported only in two middle eastern families. Catecholamines 90-104 dopa decarboxylase Homo sapiens 0-35 10728198-1 1997 Aromatic L-amino acid decarboxylase (AADC) deficiency results in an impaired synthesis of catecholamines and serotonin, and has been reported only in two middle eastern families. Catecholamines 90-104 dopa decarboxylase Homo sapiens 37-41 9029240-3 1997 In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise. Catecholamines 47-60 catechol-O-methyltransferase Homo sapiens 81-109 9402244-1 1997 The neuropeptide galanin (GAL) is localized in the peripheral and central nervous systems as well as in the adrenal medulla where it coexists with catecholamines. Catecholamines 147-161 galanin and GMAP prepropeptide Homo sapiens 17-24 9402244-1 1997 The neuropeptide galanin (GAL) is localized in the peripheral and central nervous systems as well as in the adrenal medulla where it coexists with catecholamines. Catecholamines 147-161 galanin and GMAP prepropeptide Homo sapiens 26-29 9029240-3 1997 In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise. Catecholamines 47-60 catechol-O-methyltransferase Homo sapiens 111-115 9005974-1 1997 Catecholamines are responsible for the daily changes in hepatic lipase (HL) expression associated with feeding and fasting. Catecholamines 0-14 lipase C, hepatic type Rattus norvegicus 56-70 9364202-2 1997 On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholamines. Catecholamines 78-92 nischarin Homo sapiens 19-22 9365230-4 1997 Catecholamines, hypertensive and hypotensive drugs which are sulfated by monkey brain PSTs slightly inhibit the activity of brain GSTs. Catecholamines 0-14 glutathione S-transferase kappa 1 Homo sapiens 130-134 9180359-3 1997 Histamine (10(-8)-10(-5) M)-induced catecholamine secretion was markedly potentiated by addition of ouabain (10(-5) M) and was inhibited by a histamine-H1 receptor antagonist or incubation in a Ca2+-free medium. Catecholamines 36-49 histamine H1 receptor Bos taurus 142-163 9180359-9 1997 These results suggested that stimulation of the histamine-H1 receptor and inhibition of the Na+ pump both increase intracellular Na+ levels, resulting in increases in Ca2+ influx and catecholamine secretion. Catecholamines 183-196 histamine H1 receptor Bos taurus 48-69 9005974-1 1997 Catecholamines are responsible for the daily changes in hepatic lipase (HL) expression associated with feeding and fasting. Catecholamines 0-14 lipase C, hepatic type Rattus norvegicus 72-74 9275755-7 1997 We did not prove an association between BP and polymorphism of ACE and angiotensinogen genes, however, our findings of association of DD genotype for ACE and M235 for angiotensinogen with higher insulinemia, plasma catecholamines and plasma renin activity evoke the hypothesis, whether the bearers of these genotypes, exposed for long-time to the higher concentrations of vascoactive substances, are not the subset of hereditary threatened subjects in whom clinically evident EH will manifest during their life. Catecholamines 215-229 angiotensinogen Homo sapiens 167-182 9245500-5 1997 Immunofluorescence experiments using antibodies specific for the SERT COOH and NH2 termini, for 5HT, or for catecholamine biosynthetic enzymes suggest that SERT mediates intra-cellular 5HT accumulation by epinephrine-secreting chromaffin cells. Catecholamines 108-121 solute carrier family 6 member 4 Rattus norvegicus 156-160 9132617-8 1997 For example, in schizophrenia the IL-2 cerebrospinal fluid concentration shows a stronger relationship to the relapse probability than catecholamine metabolites. Catecholamines 135-148 interleukin 2 Homo sapiens 34-38 9339812-1 1997 One of the toxic effects of lead in the CNS is an altered functional state of the catecholamine system, especially a reduction in the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Catecholamines 82-95 tyrosine hydroxylase Macaca mulatta 146-166 9339812-1 1997 One of the toxic effects of lead in the CNS is an altered functional state of the catecholamine system, especially a reduction in the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Catecholamines 82-95 tyrosine hydroxylase Macaca mulatta 168-170 9339812-1 1997 One of the toxic effects of lead in the CNS is an altered functional state of the catecholamine system, especially a reduction in the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Catecholamines 201-214 tyrosine hydroxylase Macaca mulatta 146-166 9339812-1 1997 One of the toxic effects of lead in the CNS is an altered functional state of the catecholamine system, especially a reduction in the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Catecholamines 201-214 tyrosine hydroxylase Macaca mulatta 168-170 9114462-8 1997 These data suggest that increases in systemic arterial pressure in response to hADM (16-31) are mediated by release of catecholamines and activation of alpha-adrenergic receptors in the rat. Catecholamines 119-133 adrenomedullin Homo sapiens 79-83 9437706-8 1997 The present results suggest that BNP and CNP may regulate catecholamine secretion and modulate adrenomedullary biological actions mediated by catecholamines, such as blood arterial pressure, smooth muscle tone, and metabolic activities. Catecholamines 58-71 natriuretic peptide B Rattus norvegicus 33-36 9437706-8 1997 The present results suggest that BNP and CNP may regulate catecholamine secretion and modulate adrenomedullary biological actions mediated by catecholamines, such as blood arterial pressure, smooth muscle tone, and metabolic activities. Catecholamines 58-71 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 41-44 9437706-8 1997 The present results suggest that BNP and CNP may regulate catecholamine secretion and modulate adrenomedullary biological actions mediated by catecholamines, such as blood arterial pressure, smooth muscle tone, and metabolic activities. Catecholamines 142-156 natriuretic peptide B Rattus norvegicus 33-36 9437706-8 1997 The present results suggest that BNP and CNP may regulate catecholamine secretion and modulate adrenomedullary biological actions mediated by catecholamines, such as blood arterial pressure, smooth muscle tone, and metabolic activities. Catecholamines 142-156 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 41-44 9031588-3 1996 Biosynthesis enzymes of catecholamines such as DBH (dopamine beta hydroxylase) and PNMT (phenylethanol amine-N-methyl transferase) as well as the neurotransmitter serotonin , can be detected by immunohistochemical techniques from 15 to 20 prenatal days. Catecholamines 24-38 dopamine beta-hydroxylase Homo sapiens 47-50 8978500-1 1996 Production of hydrogen peroxide as a by-product of the breakdown of catecholamines by the enzyme monoamine oxidase (MAO) has been hypothesized to contribute to the increased proclivity of dopaminergic neurons for oxidative injury. Catecholamines 68-82 monoamine oxidase A Rattus norvegicus 97-114 8978500-1 1996 Production of hydrogen peroxide as a by-product of the breakdown of catecholamines by the enzyme monoamine oxidase (MAO) has been hypothesized to contribute to the increased proclivity of dopaminergic neurons for oxidative injury. Catecholamines 68-82 monoamine oxidase A Rattus norvegicus 116-119 8978500-6 1996 Our data suggests that oxidation of catecholamines by MAO can contribute to free radical damage in catecholaminergic neurons and that the low MAO-B activity levels found endogenously in these cells likely accounts for their relative resistance to MPTP toxicity. Catecholamines 36-50 monoamine oxidase A Rattus norvegicus 54-57 8988489-8 1996 One of the vesicular monoamine transmitter transporters, VMAT2, which is expressed in catecholamine neurons in the brain stem, was observed in most cells in the SCG and also in groups of cells in the adrenal medulla, where the VMAT2-positive small chromaffin cells were PNMT-negative. Catecholamines 86-99 solute carrier family 18 member A2 Homo sapiens 57-62 8988489-8 1996 One of the vesicular monoamine transmitter transporters, VMAT2, which is expressed in catecholamine neurons in the brain stem, was observed in most cells in the SCG and also in groups of cells in the adrenal medulla, where the VMAT2-positive small chromaffin cells were PNMT-negative. Catecholamines 86-99 solute carrier family 18 member A2 Homo sapiens 227-232 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Catecholamines 81-95 monoamine oxidase A Homo sapiens 0-26 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Catecholamines 81-95 monoamine oxidase A Homo sapiens 28-32 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Catecholamines 81-95 monoamine oxidase B Homo sapiens 37-41 8993404-2 1996 Compared to VIP, both PACAP-27 and PACAP-38 demonstrated potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. Catecholamines 144-157 adenylate cyclase activating polypeptide 1 Homo sapiens 22-27 8993404-2 1996 Compared to VIP, both PACAP-27 and PACAP-38 demonstrated potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. Catecholamines 144-157 adenylate cyclase activating polypeptide 1 Homo sapiens 35-40 8993404-3 1996 The differential effects of PACAP peptides on SCG NPY and catecholamine content and secretion coincided with previous studies that activated directly the sympathetic intracellular cyclic AMP-protein kinase A signaling pathway. Catecholamines 58-71 adenylate cyclase activating polypeptide 1 Homo sapiens 28-33 8993422-7 1996 The results of these experiments show that PACAP-27, PACAP-38, and VIP have significant effects on vasomotor tone that depend on the vascular bed studied and the contribution of adrenal catecholamines. Catecholamines 186-200 vasoactive intestinal peptide Sus scrofa 67-70 8980109-0 1996 Amino acids of the alpha1B-adrenergic receptor involved in agonist binding: differences in docking catecholamines to receptor subtypes. Catecholamines 99-113 adrenoceptor alpha 1B Homo sapiens 19-46 8980109-1 1996 Site-directed mutagenesis and molecular dynamics analysis of the 3-D model of the alpha1B-adrenergic receptor (AR) were combined to identify the molecular determinants of the receptor involved in catecholamine binding. Catecholamines 196-209 adrenoceptor alpha 1B Homo sapiens 82-109 8980109-1 1996 Site-directed mutagenesis and molecular dynamics analysis of the 3-D model of the alpha1B-adrenergic receptor (AR) were combined to identify the molecular determinants of the receptor involved in catecholamine binding. Catecholamines 196-209 adrenoceptor alpha 1B Homo sapiens 111-113 8980109-2 1996 Our results indicate that the three conserved serines in the fifth transmembrane domain (TMD) of the alpha1B-AR play a distinct role in catecholamine binding versus receptor activation. Catecholamines 136-149 adrenoceptor alpha 1B Homo sapiens 109-111 9031588-3 1996 Biosynthesis enzymes of catecholamines such as DBH (dopamine beta hydroxylase) and PNMT (phenylethanol amine-N-methyl transferase) as well as the neurotransmitter serotonin , can be detected by immunohistochemical techniques from 15 to 20 prenatal days. Catecholamines 24-38 dopamine beta-hydroxylase Homo sapiens 52-77 9031588-3 1996 Biosynthesis enzymes of catecholamines such as DBH (dopamine beta hydroxylase) and PNMT (phenylethanol amine-N-methyl transferase) as well as the neurotransmitter serotonin , can be detected by immunohistochemical techniques from 15 to 20 prenatal days. Catecholamines 24-38 phenylethanolamine N-methyltransferase Homo sapiens 83-87 9031588-3 1996 Biosynthesis enzymes of catecholamines such as DBH (dopamine beta hydroxylase) and PNMT (phenylethanol amine-N-methyl transferase) as well as the neurotransmitter serotonin , can be detected by immunohistochemical techniques from 15 to 20 prenatal days. Catecholamines 24-38 phenylethanolamine N-methyltransferase Homo sapiens 89-129 9004162-10 1996 We conclude that IL-2 induces a positive inotropic response in isolated rat atria through two different pathways: an indirect activation of myocardial beta-adrenergic receptors by releasing catecholamines and a direct action by increasing the production of the second messenger cAMP. Catecholamines 190-204 interleukin 2 Rattus norvegicus 17-21 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 interleukin 6 Homo sapiens 101-114 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 interleukin 6 Homo sapiens 116-120 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 tumor necrosis factor Homo sapiens 126-153 8982123-2 1996 In healthy individuals, catecholamines can inhibit the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) via interaction with beta 2-adrenergic receptors. Catecholamines 24-38 tumor necrosis factor Homo sapiens 155-164 8982123-3 1996 In contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). Catecholamines 31-45 interleukin 6 Homo sapiens 82-95 8982123-3 1996 In contrast, we show here that catecholamines can stimulate the production of the interleukin-6 (IL-6) in children with the chronic inflammatory disease polyarticular juvenile rheumatoid arthritis (JRA). Catecholamines 31-45 interleukin 6 Homo sapiens 97-101 8922360-0 1996 Reduced expression of the leptin gene (ob) by catecholamine through a G(S) protein-coupled pathway in 3T3-L1 adipocytes. Catecholamines 46-59 leptin Homo sapiens 26-32 8952596-11 1996 Arterial osteopontin expression was increased also by chronic catecholamine infusion, a model of vascular growth stimulation showing labile pressure elevations. Catecholamines 62-75 secreted phosphoprotein 1 Rattus norvegicus 9-20 8951664-3 1996 By all available criteria, including biochemical, immunological, and morphological analysis, we have determined that the CGRP in stably transfected PC12 cells is sorted selectively into the large, dense-core catecholamine-containing secretory vesicles. Catecholamines 208-221 calcitonin-related polypeptide alpha Rattus norvegicus 121-125 8951664-5 1996 Stimulation conditions that trigger the release of catecholamines cause a parallel burst in the release of CGRP. Catecholamines 51-65 calcitonin-related polypeptide alpha Rattus norvegicus 107-111 9004256-3 1996 Data presented in this study indicate that PACAP is a potent and efficacious secretagogue of leucine-enkephalin which was coreleased with catecholamines with identical profiles. Catecholamines 138-152 adenylate cyclase activating polypeptide 1 Bos taurus 43-48 9004256-10 1996 We conclude that PACAP might assume important noncholinergic trans-synaptic regulation of the adrenal medulla by releasing and modifying intragranular catecholamine and neuropeptide contents. Catecholamines 151-164 adenylate cyclase activating polypeptide 1 Bos taurus 17-22 9128405-7 1996 (2) Neuro-vascular junction: Previous studies, in which catecholamine drip infusion tests were carried out on patients with OH, suggested that all of cardiovascular alpha-, beta 1, and beta 2 adrenoceptors gain denervation supersensitivity in OH. Catecholamines 56-69 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 185-191 8950413-0 1996 Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. Catecholamines 71-84 dopamine receptor D2 Homo sapiens 104-108 9100459-0 1996 Potentiation by ouabain of catecholamine secretion from bovine adrenal chromaffin cells in culture induced by pituitary adenylate cyclase-activating polypeptide: evidence for involvements of Na+ and Ca2+ movements. Catecholamines 27-40 adenylate cyclase activating polypeptide 1 Bos taurus 110-160 9100459-1 1996 The effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on catecholamine secretion with ouabain, an inhibitor of Na(+)-K+ ATPase, in cultured bovine adrenal chromaffin cells was examined, to determine whether movement of Na+, as well as Ca2+, is involved in the secretory process. Catecholamines 76-89 adenylate cyclase activating polypeptide 1 Bos taurus 66-71 9100459-2 1996 PACAP (10(-10)-10(-6)M)-induced catecholamine secretion was markedly potentiated by addition of ouabain (10(-5)M). Catecholamines 32-45 adenylate cyclase activating polypeptide 1 Bos taurus 0-5 9100459-3 1996 When cultured cells were preincubated with PACAP for 30 min in Ca(2+)-free medium in the presence of ouabain and then stimulated for 15 min with Ca(2+)-containing medium without PACAP or ouabain, their catecholamine secretion was dependent on the external Ca2+ concentration, and 45Ca2+ influx into the cells was increased. Catecholamines 202-215 adenylate cyclase activating polypeptide 1 Bos taurus 43-48 9100459-4 1996 When the cells had been preincubated with PACAP and ouabain in Na(+)-free sucrose medium, their Ca(2+)-induced catecholamine secretion was greatly reduced. Catecholamines 111-124 adenylate cyclase activating polypeptide 1 Bos taurus 42-47 9100459-6 1996 These results suggest that stimulation by PACAP and inhibition of the Na(+)-pump both increase the intracellular Na+ level, resulting in increase in Ca2+ influx and catecholamine secretion. Catecholamines 165-178 adenylate cyclase activating polypeptide 1 Bos taurus 42-47 8950413-0 1996 Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. Catecholamines 71-84 dopamine receptor D3 Homo sapiens 110-114 8950413-0 1996 Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. Catecholamines 71-84 solute carrier family 6 member 3 Homo sapiens 116-120 8950414-2 1996 Catechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, was mapped to 22q11 and is considered a possible candidate gene for schizophrenia. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 0-29 8950414-2 1996 Catechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, was mapped to 22q11 and is considered a possible candidate gene for schizophrenia. Catecholamines 77-91 catechol-O-methyltransferase Homo sapiens 31-35 8999773-4 1996 The inhibitory effect of catecholamines on insulin secretion resulted in a delayed increase of plasma level of insulin from 0.14 +/- 0.01 to 0.29 +/- 0.04 nmol/l. Catecholamines 25-39 insulin Sus scrofa 43-50 8945753-4 1996 Values of NPY-like immunoreactivity (NPY-ir) were reduced in rats receiving the treatment of pargyline, the inhibitor of monoamine oxidase, with an elevation of catecholamine in parallel. Catecholamines 161-174 neuropeptide Y Rattus norvegicus 10-13 8945753-4 1996 Values of NPY-like immunoreactivity (NPY-ir) were reduced in rats receiving the treatment of pargyline, the inhibitor of monoamine oxidase, with an elevation of catecholamine in parallel. Catecholamines 161-174 neuropeptide Y Rattus norvegicus 37-40 8945965-2 1996 Evidence for divergent regulation of the lipase by insulin has been demonstrated, but alterations in the tissue-specific response of LPL to catecholamines has not been studied in humans. Catecholamines 140-154 lipoprotein lipase Homo sapiens 133-136 8945965-10 1996 Overall, these studies indicate that in humans the response of LPL to catecholamines is tissue specific with no effect in adipose tissue but a stimulation in skeletal muscle. Catecholamines 70-84 lipoprotein lipase Homo sapiens 63-66 8945965-11 1996 Endogenous regulation of LPL in muscle by catecholamines could be important in muscle fuel metabolism and could relate to effects of adenosine 3",5"-cyclic monophosphate and/or fatty acids at the level of the LPL gene. Catecholamines 42-56 lipoprotein lipase Homo sapiens 25-28 8999773-4 1996 The inhibitory effect of catecholamines on insulin secretion resulted in a delayed increase of plasma level of insulin from 0.14 +/- 0.01 to 0.29 +/- 0.04 nmol/l. Catecholamines 25-39 insulin Sus scrofa 111-118 8969940-12 1996 The role of 11 beta-HSD within the adrenal gland remains obscure, but at least in the rat, the expression of the reductase enzyme, 11 beta-HSD1, to the corticomedullary junction may serve to maintain high medullary glucocorticoid concentrations required for catecholamine biosynthesis. Catecholamines 258-271 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 Rattus norvegicus 113-143 8969945-8 1996 It is concluded that VIP is a paracrine messenger in the human adrenal that could regulate adrenocortical function at least in part via catecholamines released from the medulla. Catecholamines 136-150 vasoactive intestinal peptide Homo sapiens 21-24 8921945-12 1996 Thus, the present study provides the first evidence that endogenous catecholamines are of critical importance in determining the magnitude of the IL-10 response in experimental endotoxemia. Catecholamines 68-82 interleukin 10 Mus musculus 146-151 8978485-10 1996 Because a similar mechanism of LPL regulation occurs in response to epinephrine, the absence of the translation repressor may be a mechanism for the loss of sensitivity of hypothyroid cells for catecholamines. Catecholamines 194-208 lipoprotein lipase Rattus norvegicus 31-34 8933358-0 1996 Involvement of medullary catecholamine cells in neuroendocrine responses to systemic cholecystokinin. Catecholamines 25-38 cholecystokinin Mus musculus 85-100 8878434-2 1996 We wondered if insulin or IGF-I induced expression of alpha1 adrenergic receptors in vascular smooth muscle cells (VSMCs) which could enhance smooth muscle contraction and cell growth activated by catecholamines. Catecholamines 197-211 insulin-like growth factor 1 Rattus norvegicus 26-31 8930940-1 1996 The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Catecholamines 128-142 galanin and GMAP prepropeptide Homo sapiens 17-24 8930940-1 1996 The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous systems where it often coexists with catecholamines and acetylcholine. Catecholamines 128-142 galanin and GMAP prepropeptide Homo sapiens 26-29 8878434-8 1996 These results suggest that insulin/IGF-I regulate expression of alpha1 receptors in VSMCs and potentially enhance the effects of catecholamines in settings of hyperinsulinemia. Catecholamines 129-143 insulin-like growth factor 1 Rattus norvegicus 35-40 8915186-2 1996 When exposed to endotoxin, cytokines or ischemia-reperfusion, the liver produces larger amounts of NO than those in the control via the activity of inducible NO synthase which can alter a variety of organ functions such as sensitivity of vascular tone to catecholamine, mitochondrial membrane potential, biliary transport and tissue regeneration. Catecholamines 255-268 nitric oxide synthase 2 Homo sapiens 148-169 8798695-2 1996 Tyrosine hydroxylase is an iron-containing monooxygenase that uses a tetrahydropterin to catalyze the hydroxylation of tyrosine to dihydroxyphenylalanine in catecholamine biosynthesis. Catecholamines 157-170 tyrosine hydroxylase Rattus norvegicus 0-20 8798695-4 1996 Purification of recombinant rat tyrosine hydroxylase containing 0.5-0.7 iron atoms/subunit and lacking bound catecholamine has permitted studies of the redox states of the resting enzyme and the enzyme during catalysis. Catecholamines 109-122 tyrosine hydroxylase Rattus norvegicus 32-52 8897991-10 1996 Analysis of de novo protein synthesis ([35S]methionine incorporation) demonstrated that catecholamines stimulate the synthesis of several proteins besides CAII. Catecholamines 88-102 carbonic anhydrase 2 Gallus gallus 155-159 8897002-2 1996 In the present study, we aimed at investigation in hVSMC: 1) the interrelationships between insulin-induced increases of cGMP and cAMP; 2) the insulin effect on the catecholamine modulation of cAMP. Catecholamines 165-178 insulin Homo sapiens 143-150 8897002-2 1996 In the present study, we aimed at investigation in hVSMC: 1) the interrelationships between insulin-induced increases of cGMP and cAMP; 2) the insulin effect on the catecholamine modulation of cAMP. Catecholamines 165-178 cathelicidin antimicrobial peptide Homo sapiens 193-197 8858921-5 1996 Veratridine-induced 45Ca2+ influx via voltage-dependent Ca2+ channels and catecholamine secretion were also enhanced by insulin treatment, whereas insulin did not alter nicotine-induced 22Na+ influx via the nicotinic receptor-ion channel complex and high-K+ (direct activation of voltage-dependent Ca2+ channels)-induced 45Ca2+ influx. Catecholamines 74-87 insulin Bos taurus 120-127 8858996-6 1996 The potency of catecholamines at the human beta-3 adrenoceptor was found to be 1 to 2 orders of magnitude higher when determined in an intact cell cAMP accumulation assay compared with a membrane-based adenylyl cyclase activation assay. Catecholamines 15-29 adrenoceptor beta 3 Homo sapiens 43-62 8914428-4 1996 Several mechanisms mediated by hyperinsulinemia can be entertained as follows: 1) sodium and water retention, 2) increased sympathetic nerve activity and reduced catecholamine clearance, 3) increased intracellular calcium concentration and reduced magnesium concentration, 4) increased coagulant activity and impaired fibrinolytic activity, 5) impaired endothelium-dependent NO synthesis and release, 6) increased vascular responsiveness for the vasoactive substrates, 7) increased proliferation of vascular smooth muscle cell by activation of protein kinase C or mediated by insulin and IGF-1 action. Catecholamines 162-175 insulin Homo sapiens 36-43 8798567-7 1996 Moreover, in neuronal cells COUP-TF and dopamine, a catecholamine neurotransmitter, enhance LTR-directed transcription by acting on the proximal LTR region. Catecholamines 52-65 nuclear receptor subfamily 2 group F member 1 Homo sapiens 28-35 9086498-11 1996 Since DBH is expression of catecholamine secretion, its decreased activity could represent an indirect index of altered turnover rate of the physiological substrate (i.e.dopamine) at the neuronal level. Catecholamines 27-40 dopamine beta-hydroxylase Homo sapiens 6-9 8902889-1 1996 Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline. Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 0-29 8902889-1 1996 Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline. Catecholamines 62-76 catechol-O-methyltransferase Homo sapiens 31-35 8858935-0 1996 Acidic fibroblast growth factor and catecholamines synergistically up-regulate tyrosine hydroxylase activity in developing and damaged dopamine neurons in culture. Catecholamines 36-50 tyrosine hydroxylase Rattus norvegicus 79-99 8858935-1 1996 Our previous studies indicate that, in certain non-catecholamine (CA) neurons, expression of the gene for the CA biosynthetic enzyme tyrosine hydroxylase (TH) can be initiated by the obligatory interaction of acidic fibroblast growth factor (aFGF) and a CA activator. Catecholamines 51-64 tyrosine hydroxylase Rattus norvegicus 133-153 8858935-1 1996 Our previous studies indicate that, in certain non-catecholamine (CA) neurons, expression of the gene for the CA biosynthetic enzyme tyrosine hydroxylase (TH) can be initiated by the obligatory interaction of acidic fibroblast growth factor (aFGF) and a CA activator. Catecholamines 51-64 tyrosine hydroxylase Rattus norvegicus 155-157 8858935-1 1996 Our previous studies indicate that, in certain non-catecholamine (CA) neurons, expression of the gene for the CA biosynthetic enzyme tyrosine hydroxylase (TH) can be initiated by the obligatory interaction of acidic fibroblast growth factor (aFGF) and a CA activator. Catecholamines 51-64 fibroblast growth factor 1 Rattus norvegicus 209-240 9388967-3 1996 In aldosteronomas ET-1 receptro may be down-regulated and ET-1 may play a paracrine role in regulating catecholamine in pheochromocytoma. Catecholamines 103-116 endothelin 1 Homo sapiens 58-62 8912950-2 1996 In an attempt to identify the involved genes, several linkage and association studies have focused on the gene coding for tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis. Catecholamines 172-185 tyrosine hydroxylase Homo sapiens 122-142 8836156-12 1996 Indeed, the second messenger of catecholamines is the main activator of HSL by phosphorylation. Catecholamines 32-46 lipase, hormone sensitive Mus musculus 72-75 8930982-5 1996 Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells. Catecholamines 124-137 cholecystokinin Bos taurus 107-110 8897640-1 1996 We previously reported that atrial natriuretic factor (ANF) regulates catecholamine metabolism in the central nervous system. Catecholamines 70-83 natriuretic peptide A Rattus norvegicus 28-53 8897640-1 1996 We previously reported that atrial natriuretic factor (ANF) regulates catecholamine metabolism in the central nervous system. Catecholamines 70-83 natriuretic peptide A Rattus norvegicus 55-58 8809065-0 1996 Release of secretory phospholipase A2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion. Catecholamines 109-122 phospholipase A2 group IIA Rattus norvegicus 11-37 8794928-1 1996 Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET). Catecholamines 96-109 solute carrier family 6 member 2 Homo sapiens 261-264 8794928-1 1996 Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET). Catecholamines 96-109 solute carrier family 6 member 2 Homo sapiens 324-350 8794928-1 1996 Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET). Catecholamines 96-109 solute carrier family 6 member 2 Homo sapiens 352-356 8843757-0 1996 Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Catecholamines 96-110 interleukin 6 Homo sapiens 20-33 8843757-1 1996 In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. Catecholamines 36-50 interleukin 6 Homo sapiens 72-85 8843757-1 1996 In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. Catecholamines 36-50 interleukin 6 Homo sapiens 87-91 8843757-6 1996 These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels. Catecholamines 86-100 interleukin 6 Homo sapiens 28-32 8843757-6 1996 These findings suggest that IL-6 secretion is stimulated during exercise, possibly by catecholamines, whereas exogenous glucocorticoids attenuate this effect without affecting the catecholamine levels. Catecholamines 86-99 interleukin 6 Homo sapiens 28-32 8809065-1 1996 Here we show that secretory phospholipase A2 (sPLA2) that is immunochemically indistinguishable from type II sPLA2 is (i) stored in neuroendocrine cells, (ii) released in response to neurotransmitters or depolarization, and (iii) involved in the regulation of catecholamine secretion by these cells. Catecholamines 260-273 phospholipase A2 group IIA Rattus norvegicus 18-44 8809065-1 1996 Here we show that secretory phospholipase A2 (sPLA2) that is immunochemically indistinguishable from type II sPLA2 is (i) stored in neuroendocrine cells, (ii) released in response to neurotransmitters or depolarization, and (iii) involved in the regulation of catecholamine secretion by these cells. Catecholamines 260-273 phospholipase A2 group IIA Rattus norvegicus 46-51 8809065-8 1996 Inhibitors specific to type II sPLA2 suppressed catecholamine secretion by PC12 cells which had been activated by carbamylcholine. Catecholamines 48-61 phospholipase A2 group IIA Rattus norvegicus 31-36 8809065-9 1996 Furthermore, treatment of PC12 cells with exogenous type II sPLA2 alone elicited catecholamine secretion. Catecholamines 81-94 phospholipase A2 group IIA Rattus norvegicus 60-65 8880407-4 1996 Neonatal asphyxia, i.e., decreased blood pH and increased blood pCO2 and lactate, was associated with the production of unusually high levels of catecholamines. Catecholamines 145-159 PCO2 Sus scrofa 64-68 8756565-5 1996 Using an indirect immunological approach (plasma membrane localization of dopamine-beta-hydroxylase), we demonstrated that stimulation of rat adrenal medulla V1b receptor leads to catecholamine secretion. Catecholamines 180-193 dopamine beta-hydroxylase Rattus norvegicus 74-99 8891519-7 1996 We propose that catecholamines prevent hypoglycaemia during exercise when changes in insulin and C-peptide do not occur. Catecholamines 16-30 insulin Homo sapiens 85-92 8891519-7 1996 We propose that catecholamines prevent hypoglycaemia during exercise when changes in insulin and C-peptide do not occur. Catecholamines 16-30 insulin Homo sapiens 97-106 8918684-4 1996 Using a model of insulin (0.2 U/kg)-induced hypoglycemia, we report on stress-induced responses in saliva cortisol, urinary cortisol, and urinary catacholamines relative to cortisol and catecholamine responses in plasma. Catecholamines 186-199 insulin Canis lupus familiaris 17-24 8862766-6 1996 Catecholaminergic nerves were identified as such by their content of immunoreactive tyrosine hydroxylase (TH; the rate-limiting step in catecholamine biosynthesis), and in some cases by glyoxylic acid histochemistry. Catecholamines 136-149 tyrosine hydroxylase Macaca mulatta 106-108 8876038-9 1996 For instance, we were able to show that presynaptic NPY receptors mediating catecholamine release do not solely belong to the Y2 subtype, but that presynaptic Y1 receptors also exist. Catecholamines 76-89 neuropeptide Y Homo sapiens 52-55 8752116-8 1996 These results indicate that NPY inhibits Ca2+ influx through L-type voltage-gated Ca2+ channels, possibly through a PKC-mediated pathway, resulting in attenuation of the activation of CaM kinase and inhibition of depolarization-stimulated catecholamine synthesis. Catecholamines 239-252 neuropeptide Y Rattus norvegicus 28-31 8772140-8 1996 It is concluded that the release of catecholamine content from the individual vesicles in bovine chromaffin cells is probably mostly determined by the dissociation of catecholamines from the matrix of chromogranin A. Catecholamines 36-49 chromogranin A Bos taurus 201-215 8752116-0 1996 Mechanism of catecholamine synthesis inhibition by neuropeptide Y: role of Ca2+ channels and protein kinases. Catecholamines 13-26 neuropeptide Y Rattus norvegicus 51-65 8752116-1 1996 We have previously demonstrated that neuropeptide Y (NPY) inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma (PC12) cells differentiated to a sympathetic neuronal phenotype with nerve growth factor (NGF). Catecholamines 93-106 neuropeptide Y Rattus norvegicus 37-51 8752116-1 1996 We have previously demonstrated that neuropeptide Y (NPY) inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma (PC12) cells differentiated to a sympathetic neuronal phenotype with nerve growth factor (NGF). Catecholamines 93-106 neuropeptide Y Rattus norvegicus 53-56 8752116-2 1996 The present study uses multiple selective Ca2+ channel and protein kinase agonists and antagonists to elucidate the mechanisms by which NPY modulates catecholamine synthesis as determined by in situ measurement of DOPA production in the presence of the decarboxylase inhibitor m-hydroxybenzylhydrazine (NSD-1015). Catecholamines 150-163 neuropeptide Y Rattus norvegicus 136-139 8885212-0 1996 Growth hormone treatment of hypophysectomized rats increases catecholamine-induced lipolysis and the number of beta-adrenergic receptors in adipocytes: no differences in the effects of growth hormone on different fat depots. Catecholamines 61-74 gonadotropin releasing hormone receptor Rattus norvegicus 0-14 8902882-0 1996 Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Catecholamines 42-56 interleukin 10 Homo sapiens 85-99 8902882-5 1996 Norepinephrine and epinephrine also suppressed IL-12 production in a dose-dependent fashion and at physiological concentrations; both catecholamines, however, dose-dependently increased the production of IL-10. Catecholamines 134-148 interleukin 10 Homo sapiens 204-209 8902882-6 1996 The effects of either catecholamine on IL-12 or IL-10 secretion were blocked completely by propranolol, a beta-adrenoreceptor antagonist, indicating that they were mediated by the beta-adrenergic receptor. Catecholamines 22-35 interleukin 10 Homo sapiens 48-53 8876997-2 1996 Co-treatments with five different inhibitors of poly(ADP-ribose) polymerase (PARP), including benzamide, significantly prevented the MPTP-induced catecholamine depletions. Catecholamines 146-159 poly (ADP-ribose) polymerase family, member 1 Mus musculus 48-75 8876997-2 1996 Co-treatments with five different inhibitors of poly(ADP-ribose) polymerase (PARP), including benzamide, significantly prevented the MPTP-induced catecholamine depletions. Catecholamines 146-159 poly (ADP-ribose) polymerase family, member 1 Mus musculus 77-81 8770025-6 1996 IL-1ra also blunted the increase in plasma catecholamines, but not the elevation in glucagon and corticosterone concentrations, observed after LPS. Catecholamines 43-57 interleukin 1 receptor antagonist Rattus norvegicus 0-6 8770025-9 1996 These data indicate that a major portion of the stimulation of glucose flux, as well as the increase in plasma catecholamines in response to LPS, is mediated by IL-1 within the central nervous system. Catecholamines 111-125 interleukin 1 receptor antagonist Rattus norvegicus 161-165 8706494-1 1996 OBJECTIVES: To investigate responsiveness to exogenous catecholamines in rat bacteremic shock by studying both myocardial and vascular functional parameters; to determine in the same study the relationship of these parameters with other relevant biological parameters of the adrenergic pathway, such as myocardial beta-adrenergic receptors and cyclic adenosine monophosphate (cAMP); and to indirectly approach the roles of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide. Catecholamines 55-69 tumor necrosis factor Rattus norvegicus 423-450 8706494-1 1996 OBJECTIVES: To investigate responsiveness to exogenous catecholamines in rat bacteremic shock by studying both myocardial and vascular functional parameters; to determine in the same study the relationship of these parameters with other relevant biological parameters of the adrenergic pathway, such as myocardial beta-adrenergic receptors and cyclic adenosine monophosphate (cAMP); and to indirectly approach the roles of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide. Catecholamines 55-69 tumor necrosis factor Rattus norvegicus 452-461 8858214-13 1996 Thus, lipolytic catecholamine resistance in fat cells, at least partly due to impaired function of hormone-sensitive lipase, is an adipocyte abnormality associated with a family tendency to obesity. Catecholamines 16-29 lipase E, hormone sensitive type Homo sapiens 99-123 8842899-12 1996 In conclusion, NF-L in bovine chromaffin cells demonstrates that at least one neuronal trait persists in these catecholamine-producing cells of the mature adrenal gland. Catecholamines 111-124 neurofilament light chain Bos taurus 15-19 8690060-7 1996 The presence of catecholamines and NPY in graft tissue was confirmed by tyrosine-hydroxylase-positive, dopamine beta-hydroxylase-positive, and NPY-positive cells. Catecholamines 16-30 neuropeptide Y Macaca mulatta 143-146 8837221-12 1996 The data thus strengthen earlier observations indicating an important regulatory role of PACAP in catecholamine biosynthesis and release. Catecholamines 98-111 adenylate cyclase activating polypeptide 1 Rattus norvegicus 89-94 8842392-6 1996 Depleting the brain of catecholamines prior to hypoxia, by treating the animals with alpha-methyl-p-tyrosine (AMT), resulted in a major change in the hsp72 mRNA expression. Catecholamines 23-37 heat shock protein family A (Hsp70) member 1A Homo sapiens 150-155 8842392-7 1996 In the catecholamine depleted group of animals, the intensity of hsp72 mRNA expression was greatly decreased or almost completely abolished relative to the nondepleted hypoxic group. Catecholamines 7-20 heat shock protein family A (Hsp70) member 1A Homo sapiens 65-70 8842392-8 1996 These results suggest that the catecholamines play a significant role in the expression of the hsp72 gene in response to hypoxic insult in neonatal brain. Catecholamines 31-45 heat shock protein family A (Hsp70) member 1A Homo sapiens 95-100 8663339-9 1996 These findings suggest that CgA serves as a substrate for several multifunctional protein kinases and that the elevation of the intracellular Ca2+ stimulates the phosphorylation of CgA associated with catecholamine secretion in cultured adrenal medullary cells. Catecholamines 201-214 chromogranin A Bos taurus 181-184 8842578-12 1996 We conclude that salivary alpha-amylase concentrations are predictive of plasma catecholamine levels, particularly NE, under a variety of stressful conditions, and may be a more direct and simple end point of catecholamine activity than are changes in heart rate. Catecholamines 80-93 amylase alpha 1A Homo sapiens 17-39 8877075-11 1996 The improvement in diastolic function achieved by ACE inhibition at rest and during CPT appears unrelated to plasma catecholamines and only partly ascribable to the reduced pressure load. Catecholamines 116-130 angiotensin I converting enzyme Homo sapiens 50-53 8807025-14 1996 The presence of chromogranin A early in gestation may indicate its necessity for catecholamine storage. Catecholamines 81-94 chromogranin A Sus scrofa 16-30 8842578-12 1996 We conclude that salivary alpha-amylase concentrations are predictive of plasma catecholamine levels, particularly NE, under a variety of stressful conditions, and may be a more direct and simple end point of catecholamine activity than are changes in heart rate. Catecholamines 209-222 amylase alpha 1A Homo sapiens 17-39 8767166-7 1996 It has been proposed that immature beta cells could express tyrosine hydroxylase, the first enzyme of the catecholamine biosynthetic pathway, but additional markers are needed to further characterize these immature cells. Catecholamines 106-119 tyrosine hydroxylase Homo sapiens 60-80 8935599-11 1996 Long-term therapy with somatostatin analogues of catecholamine-secreting (malignant) paragangliomas and phaeochromocytomas has not shown clinical benefits. Catecholamines 49-62 somatostatin Homo sapiens 23-35 8682183-10 1996 Further experiments, in which cultures were initiated from single cells, showed that the presence of BMP-2 resulted in colonies containing numerous catecholamine-positive cells without altering the overall number of colonies which survived and developed. Catecholamines 148-161 bone morphogenetic protein 2 Homo sapiens 101-106 8809522-9 1996 (2) In mode 10/60 s, heart rate and systolic blood pressure increased significantly (82 +/- 4 --> 85 +/- 4 beats.min-1; 124 +/- 5 --> 134 +/- 5 mmHg; P < 0.05 each), while in mode 15/60 s catecholamines increased significantly (norepinephrine 0.804 +/- 0.089 --> 1.135 +/- 0.094 nmol.l-1; P < 0.008; epinephrine 0.136 +/- 0.012 --> 0.193 +/- 0.019 nmol.l-1; P < 0.005). Catecholamines 197-211 CD59 molecule (CD59 blood group) Homo sapiens 116-121 8901462-7 1996 The catecholamines isoproterenol and norepinephrine stimulated the activity of myocardial G-6-PD in a time- and dose-dependent manner. Catecholamines 4-18 glucose-6-phosphate dehydrogenase Rattus norvegicus 90-96 8761923-2 1996 We therefore combined immunoperoxidase labeling for the R1 subunit of the N-methy-D-aspartate (NMDA) receptor with immunogold-silver localization of the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), in single sections through the rat LC to determine the subcellular localization of this glutamate receptor subtype with respect to the noradrenergic neurons. Catecholamines 153-166 tyrosine hydroxylase Rattus norvegicus 188-208 9592318-5 1996 Our data may suggest that there is the down-regulation for ET-1 receptor in APA and support the concept of an important role of ET-1 in the paracrine-autocrine regulation of aldosterone and catecholamine secretion in the adrenal and adrenal tumors. Catecholamines 190-203 endothelin 1 Homo sapiens 59-63 9592318-5 1996 Our data may suggest that there is the down-regulation for ET-1 receptor in APA and support the concept of an important role of ET-1 in the paracrine-autocrine regulation of aldosterone and catecholamine secretion in the adrenal and adrenal tumors. Catecholamines 190-203 endothelin 1 Homo sapiens 128-132 8687479-0 1996 Characterization of the catecholamine extraneuronal uptake2 carrier in human glioma cell lines SK-MG-1 and SKI-1 in relation to (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) selective cytotoxicity. Catecholamines 24-37 membrane bound transcription factor peptidase, site 1 Homo sapiens 107-112 8662851-7 1996 These results suggest that the phosphorylation of SNAP-25 may be involved in protein kinase C-mediated regulation of catecholamine release from PC12 cells. Catecholamines 117-130 synaptosome associated protein 25 Rattus norvegicus 50-57 8807741-1 1996 Juxtaglomerular (JG) neurons of rat olfactory bulb (OB) have been shown to express tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine synthesis pathway. Catecholamines 142-155 tyrosine hydroxylase Rattus norvegicus 83-103 8807741-1 1996 Juxtaglomerular (JG) neurons of rat olfactory bulb (OB) have been shown to express tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine synthesis pathway. Catecholamines 142-155 tyrosine hydroxylase Rattus norvegicus 105-107 8761923-5 1996 At the ultrastructural level, immunoperoxidase labeling for NMDA-R1 was selectively distributed in astrocytic processes and within presynaptic axon terminals but was rarely seen in catecholamine-containing somata or dendrites. Catecholamines 181-194 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 60-67 8761928-15 1996 Bombesin coexists with catecholamines in neurons in the dorsal subnucleus, which likely mediate, in part, the cardiovascular effects of bombesin. Catecholamines 23-37 gastrin releasing peptide Homo sapiens 136-144 8909778-7 1996 We conclude that after foot-shock stress, right atria from female rats sacrificed at diestrus showed subsensitivity of the chronotropic response to catecholamines as a result of a conformational alteration of beta 1-adrenoceptors, simultaneously with an increase in beta 2-adrenoceptor-mediated response. Catecholamines 148-162 adrenoceptor beta 2 Rattus norvegicus 266-285 8640984-3 1996 Catecholamines increase expression of ET-1 mRNA by cultured myocytes. Catecholamines 0-14 endothelin 1 Rattus norvegicus 38-42 8640982-2 1996 Long-term nitroglycerin infusion is associated with increases in plasma renin activity and catecholamine release rates, both of which may lead to excess angiotensin II and alpha-adrenergic-mediated vasoconstriction, particularly on withdrawal of nitroglycerin. Catecholamines 91-104 angiotensinogen Homo sapiens 153-167 9070382-2 1996 The benefits of ACE inhibition include not only a reduction in blood pressure but also improved insulin responsiveness, prevention of potassium loss, diminished myocardial oxygen demand, suppression of catecholamines, and interaction with bradykinin and prostaglandins. Catecholamines 202-216 angiotensin I converting enzyme Homo sapiens 16-19 8806925-9 1996 In conclusion, neural and humoral mechanisms exert redundant control with regard to responses of catecholamines and pituitary hormones (growth hormone and adrenocorticotropic hormone). Catecholamines 97-111 growth hormone 1 Homo sapiens 136-150 8799658-8 1996 Plasma GLP-1 levels were similar on the two GLP-1 infusion days and resulted in: (1) a significant decrease in plasma glucose from 5.2 +/- 0.2 to 4.1 +/- 0.1 mmol l-1 with GLP-1/propranolol infusion, and from 5.2 +/- 0.1 to 4.0 +/- 0.1 mmol l-1 with GLP-1/saline infusion (NS); (2) a corresponding significant increase in plasma insulin from 58.0 +/- 6.3 to 144.5 +/- 22.3 pmol l-1 and from 61.7 +/- 6.4 to 148.2 +/- 34.0 pmol l-1, respectively (NS); (3) a significant decrease in plasma glucagon from 11.7 +/- 1.6 to 6.5 +/- 1.5 pmol l-1 and from 10.4 +/- 1.6 to 4.6 +/- 1.0 pmol l-1, respectively; (4) a significant decrease in the rate of glucose appearance which was not significantly different on the two GLP-1 infusion days; and (5) an increase in catecholamine levels in the GLP-1/saline experiment and also in the beta-blockade experiments. Catecholamines 754-767 glucagon Homo sapiens 7-12 8806925-9 1996 In conclusion, neural and humoral mechanisms exert redundant control with regard to responses of catecholamines and pituitary hormones (growth hormone and adrenocorticotropic hormone). Catecholamines 97-111 proopiomelanocortin Homo sapiens 155-182 8631854-0 1996 A non-cholinergic transmitter, pituitary adenylate cyclase-activating polypeptide, utilizes a novel mechanism to evoke catecholamine secretion in rat adrenal chromaffin cells. Catecholamines 119-132 adenylate cyclase activating polypeptide 1 Rattus norvegicus 31-81 8682860-0 1996 Annexin II in exocytosis: catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells. Catecholamines 26-39 annexin A2 Homo sapiens 0-10 8682860-0 1996 Annexin II in exocytosis: catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells. Catecholamines 26-39 annexin A2 Homo sapiens 80-83 8682860-5 1996 A synthetic peptide corresponding to the NH2-terminal domain of p36 which contains the phosphorylation sites was microinjected into individual chromaffin cells and catecholamine secretion was monitored by amperometry. Catecholamines 164-177 annexin A2 Homo sapiens 64-67 8649344-10 1996 Our results indicate that NO and CNP peptide inhibit secretagogue-stimulated catecholamine release via activation of soluble and particulate isoforms of the guanylate cyclase, respectively, presumably by inhibition of calcium entry through voltage-activated calcium channels. Catecholamines 77-90 natriuretic peptide C Bos taurus 33-36 8649344-10 1996 Our results indicate that NO and CNP peptide inhibit secretagogue-stimulated catecholamine release via activation of soluble and particulate isoforms of the guanylate cyclase, respectively, presumably by inhibition of calcium entry through voltage-activated calcium channels. Catecholamines 77-90 guanylate cyclase Bos taurus 157-174 8807664-1 1996 Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 0-28 8807664-1 1996 Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. Catecholamines 48-62 catechol-O-methyltransferase Homo sapiens 30-34 8807664-5 1996 The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur, including mood disorders, schizophrenia, obsessive compulsive disorder, alcohol and substance abuse, and attention deficit hyperactivity disorder. Catecholamines 220-233 catechol-O-methyltransferase Homo sapiens 153-157 8829205-5 1996 In rats, both NS-3 and thyrotropin-releasing hormone produced a regionally specific increase in the concentrations of the catecholamine metabolites. Catecholamines 122-135 mal, T-cell differentiation protein Rattus norvegicus 14-18 8829205-5 1996 In rats, both NS-3 and thyrotropin-releasing hormone produced a regionally specific increase in the concentrations of the catecholamine metabolites. Catecholamines 122-135 thyrotropin releasing hormone Rattus norvegicus 23-52 8829205-7 1996 These findings indicate that NS-3 was far more potent than thyrotropin-releasing hormone in facilitating the turnover of catecholamines without affecting serotonin turnover in the mouse and rat brain. Catecholamines 121-135 mal, T-cell differentiation protein Rattus norvegicus 29-33 8829205-7 1996 These findings indicate that NS-3 was far more potent than thyrotropin-releasing hormone in facilitating the turnover of catecholamines without affecting serotonin turnover in the mouse and rat brain. Catecholamines 121-135 thyrotropin releasing hormone Mus musculus 59-88 8667208-5 1996 In SK-N-MC cells with similar Vmax values for both catecholamines, noradrenaline transporter expressing cells were killed by lower concentrations of MPP+ in the medium than dopamine transporter expressing cells. Catecholamines 51-65 solute carrier family 6 member 2 Homo sapiens 67-92 8726999-3 1996 Previous odorant deprivation studies that employed unilateral naris closure in neonatal rats demonstrated down-regulation of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in dopamine neurons intrinsic to the olfactory bulb. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 163-183 8726999-3 1996 Previous odorant deprivation studies that employed unilateral naris closure in neonatal rats demonstrated down-regulation of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in dopamine neurons intrinsic to the olfactory bulb. Catecholamines 129-142 tyrosine hydroxylase Rattus norvegicus 185-187 8643547-9 1996 Catecholamines exhibit a 3-fold higher affinity, and histamine exhibits a 30-fold higher affinity, for VMAT2. Catecholamines 0-14 solute carrier family 18 member A2 Homo sapiens 103-108 8631854-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP) is the most potent non-cholinergic neurotransmitter to stimulate catecholamine secretion from rat chromaffin cells; however, the mechanism of action is not clear. Catecholamines 124-137 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-50 8631854-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP) is the most potent non-cholinergic neurotransmitter to stimulate catecholamine secretion from rat chromaffin cells; however, the mechanism of action is not clear. Catecholamines 124-137 adenylate cyclase activating polypeptide 1 Rattus norvegicus 52-57 8736920-0 1996 The involvement of catecholamines, in hypertension, alcohol and ACE-inhibition. Catecholamines 19-33 angiotensin I converting enzyme Homo sapiens 64-67 8615322-6 1996 These findings indicate that adrenomedullin may play some important role in the pathophysiologic makeup of heart failure by its vasodilating effects against the concomitant exaggeration of humor pressor agents such as catecholamine and the renin-angiotensin system. Catecholamines 218-231 adrenomedullin Homo sapiens 29-43 8683095-2 1996 Mutations in a majority of the 18 loci of the Dopa decarboxylase (Ddc) gene cluster effect similar morphological defects of the cuticle and/or catecholamine-related abnormalities. Catecholamines 143-156 Dopa decarboxylase Drosophila melanogaster 46-64 8635568-7 1996 In addition, we provide evidence that the increased perivascular catecholamine histofluorescence previously observed following NGF infusion results from an increase in the number of perivascular axons associated with the vessel rather than from an increase in the amount of NE within individual axons. Catecholamines 65-78 nerve growth factor Rattus norvegicus 127-130 8673262-1 1996 Dopa decarboxylase (DDC) functions in insect catecholamine biochemistry to produce materials essential for cross-linking reactions that result in tanning and/or melanization, include tanning of the mosquito egg chorion and encapsulation of parasites. Catecholamines 45-58 Dopa decarboxylase Drosophila melanogaster 20-23 8737076-8 1996 The presence of insulin receptors in human red blood cells, and the relationship between insulin and catecholamine levels in the plasma led us to investigate the effect of insulin on catecholamine transport. Catecholamines 101-114 insulin Homo sapiens 89-96 8737076-8 1996 The presence of insulin receptors in human red blood cells, and the relationship between insulin and catecholamine levels in the plasma led us to investigate the effect of insulin on catecholamine transport. Catecholamines 101-114 insulin Homo sapiens 89-96 8737076-10 1996 Furthermore, the addition of exogenous insulin to red blood cells from fasting subjects significantly reduced the influx of catecholamines while no effect was observed when insulin was added to red blood cells obtained from fed subjects. Catecholamines 124-138 insulin Homo sapiens 39-46 8683095-2 1996 Mutations in a majority of the 18 loci of the Dopa decarboxylase (Ddc) gene cluster effect similar morphological defects of the cuticle and/or catecholamine-related abnormalities. Catecholamines 143-156 Dopa decarboxylase Drosophila melanogaster 66-69 8683095-3 1996 Mutations in 14 loci affect cuticle formation, cuticle sclerotization, or cuticle melanization, with mutations in 11 of these same loci (including Ddc and amd) producing melanotic psueudotumors, symptomatic, perhaps, of abnormal catecholamine metabolism. Catecholamines 229-242 Dopa decarboxylase Drosophila melanogaster 147-150 8659852-0 1996 Release of catecholamines and enkephalin peptides induced by reversal of the Na(+)-Ca2+ exchanger in chromaffin cells. Catecholamines 11-25 solute carrier family 8 member A1 Homo sapiens 77-97 8780041-6 1996 Moreover, cerebrocortical NPY-ir was reduced in rats receiving treatment with pargyline, an inhibitor of monoamine oxidase, with an elevation of catecholamine in parallel. Catecholamines 145-158 neuropeptide Y Rattus norvegicus 26-29 8792338-5 1996 Tyrosine hydroxylase and GTP cyclohydrolase I mRNAs were found to colocalize within catecholamine neurons located throughout the brain. Catecholamines 84-97 tyrosine hydroxylase Rattus norvegicus 0-20 8792338-5 1996 Tyrosine hydroxylase and GTP cyclohydrolase I mRNAs were found to colocalize within catecholamine neurons located throughout the brain. Catecholamines 84-97 GTP cyclohydrolase 1 Rattus norvegicus 25-45 8723206-4 1996 The study of a key enzyme in the synthesis of catecholamines, tyrosine hydroxylase (TH), has provided clues about these adaptive responses. Catecholamines 46-60 tyrosine hydroxylase Homo sapiens 62-82 8723206-4 1996 The study of a key enzyme in the synthesis of catecholamines, tyrosine hydroxylase (TH), has provided clues about these adaptive responses. Catecholamines 46-60 tyrosine hydroxylase Homo sapiens 84-86 8630020-0 1996 Rab3A delayed catecholamine secretion from bovine adrenal chromaffin cells. Catecholamines 14-27 RAB3A, member RAS oncogene family Bos taurus 0-5 8630020-4 1996 Rab3A plus GTP increased the frequency of the exocytosis of smaller packets of catecholamine. Catecholamines 79-92 RAB3A, member RAS oncogene family Bos taurus 0-5 8771558-0 1996 Circulating neuropeptide Y in humans: relation to changes in catecholamine levels and changes in hemodynamics. Catecholamines 61-74 neuropeptide Y Homo sapiens 12-26 8730750-19 1996 The systemic production of TNF alpha is regulated by catecholamines, but not by corticosterone, while the local production of TNF alpha in the peritoneal cavity is not regulated by basal levels of either catecholamines or corticosterone. Catecholamines 53-67 tumor necrosis factor Mus musculus 27-36 8627298-2 1996 These studies were designed to identify and characterize the subtype of nAChR mediating adrenal catecholamine release using the monoclonal antibody mAb35, which recognizes the alpha-subunit of muscle nAChRs and cross-reacts with some neuronal nAChRs. Catecholamines 96-109 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 72-77 8627298-4 1996 Pretreatment with mAb35 reduced nAChR-stimulated catecholamine release (IC50 of approximately 10nM). Catecholamines 49-62 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 32-37 8612391-0 1996 Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: effects on hemodynamics and catecholamine metabolism in healthy volunteers. Catecholamines 109-122 catechol-O-methyltransferase Homo sapiens 27-55 8612391-1 1996 OBJECTIVE: To evaluate the effects of simultaneous pharmacologic inhibition of catechol-O-methyltransferase (COMT) and monoamine oxidase type A (MAO-A) on hemodynamics and catecholamine metabolism in healthy volunteers at rest and during exercise. Catecholamines 172-185 catechol-O-methyltransferase Homo sapiens 79-107 8612391-16 1996 The changes in the catecholamine metabolite concentrations provide evidence of effective COMT and MAO inhibition. Catecholamines 19-32 catechol-O-methyltransferase Homo sapiens 89-93 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 82-95 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 8861784-8 1996 The sensitivity of the beta 3-adrenoceptor to these catecholamines, expressed as pD(2) values, were virtually identical in both adipocyte types. Catecholamines 52-66 adrenoceptor beta 3 Homo sapiens 23-42 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 82-95 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 117-130 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 8771559-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP)i a potent stimulant of catecholamine secretion, increased catecholamine production in cultured porcine adrenal medullary chromaffin cells. Catecholamines 117-130 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 8771559-2 1996 PACAP induced dose-and time-dependent increases in mRNAs for the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), with maximal 6- and 4-fold increases occurring at 8-16 h, respectively. Catecholamines 65-78 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 8771559-2 1996 PACAP induced dose-and time-dependent increases in mRNAs for the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), with maximal 6- and 4-fold increases occurring at 8-16 h, respectively. Catecholamines 65-78 tyrosine hydroxylase Homo sapiens 101-121 8771559-2 1996 PACAP induced dose-and time-dependent increases in mRNAs for the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), with maximal 6- and 4-fold increases occurring at 8-16 h, respectively. Catecholamines 65-78 tyrosine hydroxylase Homo sapiens 123-125 8771559-2 1996 PACAP induced dose-and time-dependent increases in mRNAs for the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), with maximal 6- and 4-fold increases occurring at 8-16 h, respectively. Catecholamines 65-78 dopamine beta-hydroxylase Homo sapiens 131-156 8771559-2 1996 PACAP induced dose-and time-dependent increases in mRNAs for the catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), with maximal 6- and 4-fold increases occurring at 8-16 h, respectively. Catecholamines 65-78 dopamine beta-hydroxylase Homo sapiens 158-161 8984738-4 1996 The study of a key enzyme in the synthesis of catecholamines, tyrosine hydroxylase (TH), has provided clues about these adaptive responses. Catecholamines 46-60 tyrosine hydroxylase Homo sapiens 62-82 8984738-4 1996 The study of a key enzyme in the synthesis of catecholamines, tyrosine hydroxylase (TH), has provided clues about these adaptive responses. Catecholamines 46-60 tyrosine hydroxylase Homo sapiens 84-86 9095470-0 1996 Subchronic exposure of cardiomyocytes to low concentrations of tumor necrosis factor alpha attenuates the positive inotropic response not only to catecholamines but also to cardiac glycosides and high calcium concentrations. Catecholamines 146-160 tumor necrosis factor Rattus norvegicus 63-90 8724983-2 1996 NGF and EGF, but not IFN-gamma, caused an increase after 24 h in the levels of BH4 and catecholamines, and the activities of tyrosine hydroxylase and GTP cyclohydrolase, the rate-limiting enzymes in catecholamine and BH4 synthesis, respectively. Catecholamines 87-101 nerve growth factor Rattus norvegicus 0-3 8724983-2 1996 NGF and EGF, but not IFN-gamma, caused an increase after 24 h in the levels of BH4 and catecholamines, and the activities of tyrosine hydroxylase and GTP cyclohydrolase, the rate-limiting enzymes in catecholamine and BH4 synthesis, respectively. Catecholamines 87-101 epidermal growth factor like 1 Rattus norvegicus 8-11 8742566-1 1996 OBJECTIVE: To evaluate the effects of captopril on circulating catecholamine levels in NIDDM patients and the possible relationship between captopril-related changes in circulating catecholamine levels and insulin sensitivity. Catecholamines 181-194 insulin Homo sapiens 206-213 8724983-2 1996 NGF and EGF, but not IFN-gamma, caused an increase after 24 h in the levels of BH4 and catecholamines, and the activities of tyrosine hydroxylase and GTP cyclohydrolase, the rate-limiting enzymes in catecholamine and BH4 synthesis, respectively. Catecholamines 87-100 nerve growth factor Rattus norvegicus 0-3 8724983-2 1996 NGF and EGF, but not IFN-gamma, caused an increase after 24 h in the levels of BH4 and catecholamines, and the activities of tyrosine hydroxylase and GTP cyclohydrolase, the rate-limiting enzymes in catecholamine and BH4 synthesis, respectively. Catecholamines 87-100 epidermal growth factor like 1 Rattus norvegicus 8-11 8698885-9 1996 The localization of CYP2D1 in several regions known to harbor catecholamines and serotonin may suggest a role for CYP2D1 in the metabolism of monoamines. Catecholamines 62-76 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 20-26 8698885-9 1996 The localization of CYP2D1 in several regions known to harbor catecholamines and serotonin may suggest a role for CYP2D1 in the metabolism of monoamines. Catecholamines 62-76 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 114-120 8780231-2 1996 Microinjections of somatostatin (100 pmol) into laminae I-II of trigeminal subnucleus caudalis (Vc) evoked increases in the adrenal secretion of catecholamines and adrenal blood flow without affecting arterial pressure, heart rate, or plasma adrenocorticotropic hormone. Catecholamines 145-159 somatostatin Felis catus 19-31 8965651-1 1996 As the first and rate limiting enzyme in the biosynthetic pathway for catecholamine (CA) neurotransmitters, tyrosine hydroxylase (TH) is a specific phenotypic marker for CA cells in the central and peripheral nervous systems of adult animals. Catecholamines 70-83 tyrosine hydroxylase Rattus norvegicus 108-128 8965651-1 1996 As the first and rate limiting enzyme in the biosynthetic pathway for catecholamine (CA) neurotransmitters, tyrosine hydroxylase (TH) is a specific phenotypic marker for CA cells in the central and peripheral nervous systems of adult animals. Catecholamines 70-83 tyrosine hydroxylase Rattus norvegicus 130-132 8742566-10 1996 CONCLUSIONS: The reduction of circulating catecholamines could contribute, at least in part, to the captopril-related amelioration of insulin sensitivity. Catecholamines 42-56 insulin Homo sapiens 134-141 8707711-3 1996 Somatotropin treatment resulted in a small increase in basal (unstimulated) lipolysis and also in the maximum lipolytic rate observed in the presence of catecholamines both in vivo and in vitro. Catecholamines 153-167 somatotropin Ovis aries 0-12 8619818-6 1996 The expression of beta ARK1 mRNA in the hearts of BIO53.58 was significantly increased compared to control hamsters, F1b, suggesting that the enhanced beta ARK1 expression is acting as a negative feedback mechanism in order to maintain intracellular homeostasis against accelerated stimulation by catecholamines via phosphorylation of beta-adrenergic receptor. Catecholamines 297-311 beta-adrenergic receptor kinase 1 Mesocricetus auratus 18-27 8603609-1 1996 Pituitary adenylate cyclase-activating polypeptide (PACAP) has been reported to increase intracellular Ca2+ concentrations ([Ca2+]i) and catecholamine release in adrenal chromaffin cells. Catecholamines 137-150 adenylate cyclase activating polypeptide 1 Bos taurus 0-58 8613523-6 1996 In MAO-A-deficient subjects, there is a marked decrease in deaminated catecholamine metabolites and a concomitant marked elevation of O-methylated amine metabolites. Catecholamines 70-83 monoamine oxidase A Homo sapiens 3-8 8621733-1 1996 Reduced tension of O2 slows the degradation rate of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line. Catecholamines 116-129 tyrosine hydroxylase Rattus norvegicus 61-81 8621733-1 1996 Reduced tension of O2 slows the degradation rate of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line. Catecholamines 116-129 tyrosine hydroxylase Rattus norvegicus 83-85 8619818-6 1996 The expression of beta ARK1 mRNA in the hearts of BIO53.58 was significantly increased compared to control hamsters, F1b, suggesting that the enhanced beta ARK1 expression is acting as a negative feedback mechanism in order to maintain intracellular homeostasis against accelerated stimulation by catecholamines via phosphorylation of beta-adrenergic receptor. Catecholamines 297-311 beta-adrenergic receptor kinase 1 Mesocricetus auratus 151-160 8699193-5 1996 Occasional neurons with immunoreactivity to the catecholamine-synthesizing enzyme, tyrosine hydroxylase, were also observed. Catecholamines 48-61 tyrosine hydroxylase Homo sapiens 83-103 8561211-1 1996 OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 11-39 8593828-1 1996 Brain angiotensin II (Ang II) plays a key role in blood pressure control in part by interacting with catecholamines (CA) and by stimulation of sympathetic pathways. Catecholamines 101-115 angiotensinogen Rattus norvegicus 6-20 8593828-1 1996 Brain angiotensin II (Ang II) plays a key role in blood pressure control in part by interacting with catecholamines (CA) and by stimulation of sympathetic pathways. Catecholamines 101-115 angiotensinogen Rattus norvegicus 22-28 8561211-1 1996 OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Catecholamines 59-73 catechol-O-methyltransferase Homo sapiens 41-45 9011752-5 1996 These disease-related decreases in the cellular abundance of both DAT and VMAT2 gene transcripts in the surviving cells of the parkinsonian nigra may reflect compensatory changes in catecholamine signalling or may be a consequence of neuronal dysfunction. Catecholamines 182-195 solute carrier family 6 member 3 Homo sapiens 66-69 9011752-5 1996 These disease-related decreases in the cellular abundance of both DAT and VMAT2 gene transcripts in the surviving cells of the parkinsonian nigra may reflect compensatory changes in catecholamine signalling or may be a consequence of neuronal dysfunction. Catecholamines 182-195 solute carrier family 18 member A2 Homo sapiens 74-79 8593812-6 1996 DA was studied by measuring changes in gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 113-126 tyrosine hydroxylase Rattus norvegicus 58-78 8593812-6 1996 DA was studied by measuring changes in gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 113-126 tyrosine hydroxylase Rattus norvegicus 80-82 9182249-1 1996 Catecholamine biosynthesis is regulated by tyrosine hydroxylase (TH) requiring tetrahydrobiopterin (BH4) as the cofactor. Catecholamines 0-13 tyrosine hydroxylase Homo sapiens 43-63 8632316-13 1996 These results demonstrate that (+/-)-epibatidine displays nAChR agonist activity in the rat CNS and that certain effects are mediated via nAChR-stimulated catecholamine release and subsequent activation of corresponding receptors. Catecholamines 155-168 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 138-143 8868295-1 1996 NPY is a regulatory peptide, high levels of which are contained in adrenal glands of several mammals and which is co-released with catecholamines during various stressful conditions. Catecholamines 131-145 neuropeptide Y Rattus norvegicus 0-3 9182249-1 1996 Catecholamine biosynthesis is regulated by tyrosine hydroxylase (TH) requiring tetrahydrobiopterin (BH4) as the cofactor. Catecholamines 0-13 tyrosine hydroxylase Homo sapiens 65-67 8820881-0 1996 Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain. Catecholamines 70-83 corticotropin releasing hormone Rattus norvegicus 0-30 8677204-1 1996 The aim of the study was to investigate effects of CPAP treatment on diurnal catecholamine excretion in urine in patients with obstructive sleep apnea (OSA). Catecholamines 77-90 centromere protein J Homo sapiens 51-55 8677205-12 1996 CONCLUSIONS: Hypertension and family history of it changes adrenergic reactivity and influences the relationship between plasma renin activity, aldosterone, and catecholamines. Catecholamines 161-175 renin Homo sapiens 128-133 8686529-12 1996 The postoperative maximum of IL-6 in plasma could be due to a release of catecholamines. Catecholamines 73-87 interleukin 6 Homo sapiens 29-33 8557631-2 1996 Cross-regulation among members of both receptor superfamilies has been reported, including the counter-regulatory effects of insulin on beta-adrenergic catecholamine action. Catecholamines 152-165 insulin Homo sapiens 125-132 8686529-14 1996 Increased plasma catecholamine concentrations as well as a damage in the blood-brain barrier due to the surgical trauma with a spill-over of IL-6 from brain tissue into plasma could have contributed to this result. Catecholamines 17-30 interleukin 6 Homo sapiens 141-145 8750929-8 1996 Based on these results, it can be concluded that defective catecholamine synthesis in the epidermis of patients with vitiligo leads to increased levels of norepinephrine with a concomitant increase in MAO-A activity. Catecholamines 59-72 monoamine oxidase A Homo sapiens 201-206 9199118-2 1996 The aim of the presented study is to evaluate the linear correlation between: 1) serum dopamine-beta hydroxylase activity and the dopamine concentration in plasma as well as 24-hours adrenaline and noradrenaline excretion in the urine; and 2) between catechol-0-methyltransferase and monoaminoxidase activity and the 24-hours excretion of catecholamine in the urine; next the serum and platelet concentration of serotonin and the arterial blood pressure in women chronically exposed to carbon disulfide. Catecholamines 339-352 dopamine beta-hydroxylase Homo sapiens 87-112 9162435-4 1996 Insulin resistance was characterized by higher body mass index (p = 0.002, analysis of variance), triglycerides (p = 0.001), total cholesterol/high density lipoprotein cholesterol ratio (p = 0.002), haemoglobin (p = 0.013), haematocrit (p = 0.017) and resting heart rate (p = 0.041) but not resting blood pressure or catecholamines in arterialized blood. Catecholamines 317-331 insulin Homo sapiens 0-7 8550747-0 1996 Pituitary adenylate-cyclase activating peptide enhances aldosterone secretion of human adrenal gland: evidence for an indirect mechanism, probably involving the local release of catecholamines. Catecholamines 178-192 adenylate cyclase activating polypeptide 1 Homo sapiens 0-46 8861679-0 1996 Threshold increases in plasma growth hormone in relation to plasma catecholamine and blood lactate concentrations during progressive exercise in endurance-trained athletes. Catecholamines 67-80 growth hormone 1 Homo sapiens 30-44 9206410-8 1996 Catecholamine levels in pico moles mL-1 were within the normal range at the 3-min sample level. Catecholamines 0-13 L1 cell adhesion molecule Mus musculus 35-39 8550747-10 1996 PACAP (10 nmol/L) induced a net rise in catecholamine release by adrenal slices. Catecholamines 40-53 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 8550747-11 1996 Taken together, our present findings suggest that PACAP indirectly stimulates ALDO secretion by the human adrenal cortex, probably by eliciting the local release of catecholamines by medullary chromaffin cells that are also scattered in the cortical tissue, especially the zona glomerulosa. Catecholamines 165-179 adenylate cyclase activating polypeptide 1 Homo sapiens 50-55 8598500-0 1996 Catecholamines modulate human NK cell circulation and function via spleen-independent beta 2-adrenergic mechanisms. Catecholamines 0-14 tubulin beta 4B class IVb Homo sapiens 86-92 8598500-4 1996 Lymphocyte subsets (CD3+, CD4+, CD8+) transiently increased after administration of both catecholamines, with most pronounced increases (up to 600%) in NK cell numbers (CD16+ or CD56+) after infusion of adrenaline. Catecholamines 89-103 Fc gamma receptor IIIa Homo sapiens 169-173 8598500-4 1996 Lymphocyte subsets (CD3+, CD4+, CD8+) transiently increased after administration of both catecholamines, with most pronounced increases (up to 600%) in NK cell numbers (CD16+ or CD56+) after infusion of adrenaline. Catecholamines 89-103 neural cell adhesion molecule 1 Homo sapiens 178-182 8844777-5 1996 In light of these findings the following conclusions are drawn: i) ADM and CGRP stimulate rat adrenals in vivo to release B by raising blood flow rate; ii) ADM and CGRP enhance ALDO secretion via an indirect mechanism probably requiring the release of catecholamines by medullary chromaffin cells; and iii) the effects of ADM and CGRP on the rat adrenal gland are mediated by a common receptor of the CGRP1 subtype. Catecholamines 252-266 calcitonin-related polypeptide alpha Rattus norvegicus 164-168 8522954-1 1996 The tyrosine hydroxylase (TH) gene is expressed exclusively in cells and neurons that synthesize and release L-DOPA or catecholamines. Catecholamines 119-133 tyrosine hydroxylase Mus musculus 4-24 8522954-1 1996 The tyrosine hydroxylase (TH) gene is expressed exclusively in cells and neurons that synthesize and release L-DOPA or catecholamines. Catecholamines 119-133 tyrosine hydroxylase Mus musculus 26-28 8622571-1 1996 Gonadotropin-releasing hormone (GnRH) secretion is modulated by a large number of neuromediators, among which catecholamines play a central role. Catecholamines 110-124 gonadotropin releasing hormone 1 Mus musculus 0-30 8622571-1 1996 Gonadotropin-releasing hormone (GnRH) secretion is modulated by a large number of neuromediators, among which catecholamines play a central role. Catecholamines 110-124 gonadotropin releasing hormone 1 Mus musculus 32-36 8622571-4 1996 However, in spite of a similar efficacy of these catecholamines to stimulate GnRH secretion, DA is two-fold more efficacious than NE to stimulate the formation of cyclic AMP. Catecholamines 49-63 gonadotropin releasing hormone 1 Mus musculus 77-81 8845594-5 1996 Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells. Catecholamines 0-14 interleukin 6 Homo sapiens 112-125 8845594-5 1996 Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells. Catecholamines 0-14 interleukin 6 Homo sapiens 127-131 8845594-6 1996 In differentiated FLG 29.1 cells only IL-6 release was induced by catecholamine treatment. Catecholamines 66-79 interleukin 6 Homo sapiens 38-42 8522943-4 1996 Cellular levels of dopamine-beta-hydroxylase and catecholamines were increased by NGF treatment but were not affected by EGF or insulin. Catecholamines 49-63 nerve growth factor Rattus norvegicus 82-85 9029893-8 1996 Ischemia, produced by an increase in catecholamines, and the consequent vasoconstriction, rather than hypoxemia seemed to be the cause of the negative immunoreactivity for Mb in the group pattern. Catecholamines 37-51 myoglobin Homo sapiens 172-174 8717160-0 1996 The contribution by monoamine oxidase and catechol-O-methyltransferase to the total-body and pulmonary plasma clearance of catecholamines. Catecholamines 123-137 catechol O-methyltransferase Oryctolagus cuniculus 42-70 8717160-1 1996 To study the effects of inhibition of catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) on the removal of circulating catecholamines, anaesthetized rabbits were infused for 120 min with 3H-labelled noradrenaline, adrenaline and dopamine. Catecholamines 132-146 catechol O-methyltransferase Oryctolagus cuniculus 68-72 8717160-14 1996 Combined inhibition of both MAO and COMT was highly effective in reducing the pulmonary clearance of noradrenaline and dopamine, but produced only minor decreases in the total-body clearance of all three catecholamines. Catecholamines 204-218 catechol O-methyltransferase Oryctolagus cuniculus 36-40 8844777-5 1996 In light of these findings the following conclusions are drawn: i) ADM and CGRP stimulate rat adrenals in vivo to release B by raising blood flow rate; ii) ADM and CGRP enhance ALDO secretion via an indirect mechanism probably requiring the release of catecholamines by medullary chromaffin cells; and iii) the effects of ADM and CGRP on the rat adrenal gland are mediated by a common receptor of the CGRP1 subtype. Catecholamines 252-266 calcitonin-related polypeptide alpha Rattus norvegicus 164-168 8742422-2 1995 for 4 h (09:00-11:00, 13:00-15:00)] every day for 3 weeks on immunoreactivity for tyrosine hydroxylase (TH), the rate limiting enzyme of catecholamine synthesis, in the rat forebrain were studied. Catecholamines 137-150 tyrosine hydroxylase Rattus norvegicus 82-102 8597395-2 1995 This paper describes our date regarding the expression of the prodynorphin gene, the precursor of a family of endogenous kappa opioid ligands, in the PC12 rat pheochromocytoma cell line, and the effects of synthetic kappa opioid agonists and of Naloxone on various aspects of PC12 cell function including their secretion of catecholamines, proliferation and differentiation. Catecholamines 324-338 prodynorphin Rattus norvegicus 62-74 8597401-5 1995 Stress-induced plasma NPY levels may reach the concentrations that are vasoconstrictive per se in addition to potentiating the actions of catecholamines. Catecholamines 138-152 neuropeptide Y Homo sapiens 22-25 8597401-6 1995 Reciprocally, elevated circulating levels of catecholamines during stress appear to induce hypersensitivity of blood vessels to NPY. Catecholamines 45-59 neuropeptide Y Homo sapiens 128-131 8597415-3 1995 The treatment of AtT-20 mouse pituitary adenoma cells for 24 h with neuroendocrine mediators of stress such as CRF and catecholamines produced dose-dependent increases in cAMP production and [125I]IL-1 alpha binding. Catecholamines 119-133 interleukin 1 alpha Mus musculus 197-207 8742422-2 1995 for 4 h (09:00-11:00, 13:00-15:00)] every day for 3 weeks on immunoreactivity for tyrosine hydroxylase (TH), the rate limiting enzyme of catecholamine synthesis, in the rat forebrain were studied. Catecholamines 137-150 tyrosine hydroxylase Rattus norvegicus 104-106 8847409-6 1995 More rostrally, in the region of catecholamine-immunoreactive extranuclear dendrites, ENK-immunoreactive varicose processes were interdigitated with TH-labeled processes. Catecholamines 33-46 proenkephalin Rattus norvegicus 86-89 9259051-5 1996 After balloon injury in rat aorta using in situ hybridization, the catecholamine-induced increase in c-fos mRNA expression in the medial layer was inhibited by the alpha 1 receptor antagonists, prazosin and chloroethylclonidine. Catecholamines 67-80 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 101-106 8991801-0 1995 Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells. Catecholamines 50-63 neuropeptide Y Rattus norvegicus 0-14 8991801-1 1995 In PC12 rat pheochromocytoma cells differentiated with nerve growth factor (NGF), neuropeptide Y inhibited depolarization-stimulated catecholamine synthesis as determined by in situ measurement of 3,4-dihydroxyphenylalanine (DOPA) production in the presence of the decarboxylase inhibitor m-hydroxybenzylhydrazine (NSD-1015). Catecholamines 133-146 neuropeptide Y Rattus norvegicus 82-96 8847409-12 1995 These results provide the first direct ultrastructural evidence that morphologically heterogeneous terminals containing ENK immunoreactivity form synapses with catecholamine dendrites within the LC. Catecholamines 160-173 proenkephalin Rattus norvegicus 120-123 8991801-7 1995 These results indicate that neuropeptide Y can modulate catecholamine synthesis in addition to its modulatory effects on catecholamine release. Catecholamines 56-69 neuropeptide Y Rattus norvegicus 28-42 8991801-7 1995 These results indicate that neuropeptide Y can modulate catecholamine synthesis in addition to its modulatory effects on catecholamine release. Catecholamines 121-134 neuropeptide Y Rattus norvegicus 28-42 7588334-10 1995 Double immunohistochemical procedures demonstrated that a subpopulation of these intraovarian, p75 NGFR-bearing neuron-like cells are catecholaminergic, as determined by their immunoreactivity to antibodies to tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 134-147 TNF receptor superfamily member 1B Homo sapiens 95-98 8748684-4 1995 In confluent monolayers, salsolinol stimulated catecholamine uptake with EC50 values of 17 muM and 11 muM, for noradrenaline and dopamine, respectively. Catecholamines 47-60 latexin Homo sapiens 91-94 8748684-4 1995 In confluent monolayers, salsolinol stimulated catecholamine uptake with EC50 values of 17 muM and 11 muM, for noradrenaline and dopamine, respectively. Catecholamines 47-60 latexin Homo sapiens 102-105 8748684-6 1995 The inhibition of catecholamine uptake corresponded to the increase displacement of [3H]nisoxetine from the uptake 1 site by salsolinol, as the Ki (353 muM) for displacement was similar to the IC50 (411 and 379 muM) for uptake. Catecholamines 18-31 latexin Homo sapiens 152-155 8748684-6 1995 The inhibition of catecholamine uptake corresponded to the increase displacement of [3H]nisoxetine from the uptake 1 site by salsolinol, as the Ki (353 muM) for displacement was similar to the IC50 (411 and 379 muM) for uptake. Catecholamines 18-31 latexin Homo sapiens 211-214 8748684-7 1995 Salsolinol stimulated catecholamine uptake does not involve the uptake recognition site, or elevation of cAMP, cGMP, or inhibition of protein kinase C. Salsolinol also inhibited both carbachol (1 mM) and K+ (100 mM, Na+ adjusted) evoked released of noradrenaline from SH-SY5Y cells, with IC50 values of 500 muM and 120 muM, respectively. Catecholamines 22-35 latexin Homo sapiens 307-310 8748684-7 1995 Salsolinol stimulated catecholamine uptake does not involve the uptake recognition site, or elevation of cAMP, cGMP, or inhibition of protein kinase C. Salsolinol also inhibited both carbachol (1 mM) and K+ (100 mM, Na+ adjusted) evoked released of noradrenaline from SH-SY5Y cells, with IC50 values of 500 muM and 120 muM, respectively. Catecholamines 22-35 latexin Homo sapiens 319-322 8548058-1 1995 Human galanin (hGAL) is a neuropeptide with 30 amino acid residues that has been found in the peripheral and central nervous system, where it often co-exists with catecholamines. Catecholamines 163-177 galanin and GMAP prepropeptide Homo sapiens 15-19 8664455-1 1995 OBJECTIVE: The purpose was to study whether the hemodynamic benefit of a catabolic catecholamine (dobutamine) induces a certain oxygen cost for the myocardial energy demand and whether this effect would be less pronounced if an anabolic intervention, such as the administration of insulin, was used. Catecholamines 83-96 insulin Homo sapiens 281-288 8521555-12 1995 Conversely, LQT2 patients may be at higher risk to develop syncope under stressful conditions because of the combined arrhythmogenic effect of catecholamines with the insufficient adaptation of their QT interval when heart rate increases. Catecholamines 143-157 potassium voltage-gated channel subfamily H member 2 Homo sapiens 12-16 8572200-7 1995 26): E461-E466, 1992] showed that the inflammatory mediator interleukin-1 alpha (IL-1 alpha) stimulates catecholamine release from primary cultures of rat adrenal cells. Catecholamines 104-117 interleukin 1 alpha Rattus norvegicus 60-79 8572200-7 1995 26): E461-E466, 1992] showed that the inflammatory mediator interleukin-1 alpha (IL-1 alpha) stimulates catecholamine release from primary cultures of rat adrenal cells. Catecholamines 104-117 interleukin 1 alpha Rattus norvegicus 81-91 8572200-8 1995 The present studies were conducted to determine whether 1) IL-1 alpha stimulates catecholamine/dopamine release from the adrenal medullary cell line PC-12 and 2) the adenosine 3",5"-cyclic monophosphate (cAMP)-protein kinase A (PKA) pathway is involved in IL-1 alpha-induced dopamine release from PC-12 cells. Catecholamines 81-94 interleukin 1 alpha Rattus norvegicus 59-69 8529333-2 1995 Human neuropeptide Y is an endogenous vasoconstrictor peptide that is costored with norepinephrine in sympathetic nerve endings and coreleased with the catecholamine under various physiologic and pathologic conditions. Catecholamines 152-165 neuropeptide Y Homo sapiens 6-20 8682056-3 1995 Although not entirely elucidated, injury follows Ang II-associated release of adrenal medullary catecholamines and aldosterone-induced myocardial potassium depletion. Catecholamines 96-110 angiotensinogen Homo sapiens 49-55 8998407-3 1995 A prominent feature that accompanies aging is an increase in monoamine oxidase (MAO) levels which results in decreased availability of catecholamines in the synaptic cleft. Catecholamines 135-149 monoamine oxidase A Rattus norvegicus 61-78 8998407-3 1995 A prominent feature that accompanies aging is an increase in monoamine oxidase (MAO) levels which results in decreased availability of catecholamines in the synaptic cleft. Catecholamines 135-149 monoamine oxidase A Rattus norvegicus 80-83 8613746-8 1995 When introduced into tissue culture, Arix regulates the transcriptional activity from the DBH promoter, and also from the promoter of the tyrosine hydroxylase gene, encoding the initial enzyme of the catecholamine biosynthetic pathway. Catecholamines 200-213 paired like homeobox 2A Homo sapiens 37-41 8553369-0 1995 Role of intracellular Cd2+ in catecholamine release and lethality in PC12 cells. Catecholamines 30-43 Cd2 molecule Rattus norvegicus 22-25 8613746-9 1995 The pattern of expression of the Arix transcripts, the presence of the homeodomain, and the transcriptional regulatory properties suggest that this family of proteins may be involved in the specificity of expression of the catecholamine biosynthetic genes. Catecholamines 223-236 paired like homeobox 2A Homo sapiens 33-37 7479983-19 1995 Since both catecholamines activate the release of LHRH, the inhibition of their release by NO serves as an ultra-short-loop negative feedback by which NO inhibits the release of the catecholamines, thereby reducing the activation of the NOergic neurons and decreasing the release of LHRH. Catecholamines 11-25 gonadotropin releasing hormone 1 Rattus norvegicus 50-54 7479983-19 1995 Since both catecholamines activate the release of LHRH, the inhibition of their release by NO serves as an ultra-short-loop negative feedback by which NO inhibits the release of the catecholamines, thereby reducing the activation of the NOergic neurons and decreasing the release of LHRH. Catecholamines 11-25 gonadotropin releasing hormone 1 Rattus norvegicus 283-287 7479983-19 1995 Since both catecholamines activate the release of LHRH, the inhibition of their release by NO serves as an ultra-short-loop negative feedback by which NO inhibits the release of the catecholamines, thereby reducing the activation of the NOergic neurons and decreasing the release of LHRH. Catecholamines 182-196 gonadotropin releasing hormone 1 Rattus norvegicus 50-54 7592982-1 1995 Tyrosine 3-hydroxylase (TH, EC 1.14.16.2) catalyzes the first and rate-limiting step of the catecholamine biosynthetic pathway in the nervous and endocrine systems. Catecholamines 92-105 tyrosine hydroxylase Mus musculus 0-22 7592982-1 1995 Tyrosine 3-hydroxylase (TH, EC 1.14.16.2) catalyzes the first and rate-limiting step of the catecholamine biosynthetic pathway in the nervous and endocrine systems. Catecholamines 92-105 tyrosine hydroxylase Mus musculus 24-26 7592982-4 1995 In these mice, TH activity in the embryos and adult tissues was less than 50% of the wild-type values, but the catecholamine level was decreased only moderately in the developing animals and was maintained normally at adulthood, suggesting the presence of a regulatory mechanism for ensuring the proper catecholamine level during animal development. Catecholamines 303-316 tyrosine hydroxylase Mus musculus 15-17 7592982-6 1995 Both TH mRNA and enzyme activity were lacking in the homozygous mutants, which thus explained the severe depletion of catecholamines. Catecholamines 118-132 tyrosine hydroxylase Mus musculus 5-7 7479983-19 1995 Since both catecholamines activate the release of LHRH, the inhibition of their release by NO serves as an ultra-short-loop negative feedback by which NO inhibits the release of the catecholamines, thereby reducing the activation of the NOergic neurons and decreasing the release of LHRH. Catecholamines 182-196 gonadotropin releasing hormone 1 Rattus norvegicus 283-287 7503249-0 1995 Catecholamine response to chronic ANG II infusion and its role in myocyte and coronary vascular damage. Catecholamines 0-13 angiotensinogen Homo sapiens 34-40 7503249-3 1995 Furthermore, it is unknown if this ANG II-induced catecholamine release is ANG II type 1 (AT1) receptor mediated or whether the increase in serum catecholamines is responsible for the myocyte and coronary vascular damage seen within the first 3 days of chronic ANG II infusion. Catecholamines 50-63 angiotensinogen Homo sapiens 35-41 7491942-0 1995 PACAP stimulates catecholamine release from adrenal medulla: a novel noncholinergic secretagogue. Catecholamines 17-30 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 7491942-2 1995 The injection of PACAP (1.5 nmol) caused a greater amount of increase in catecholamine concentration than carbachol (30 nmol) or VIP (30 nmol) in the dialysate for a period of 60 min. Catecholamines 73-86 adenylate cyclase activating polypeptide 1 Rattus norvegicus 17-22 7491942-5 1995 In contrast, PACAP-induced catecholamine secretion was not inhibited by these cholinergic antagonists. Catecholamines 27-40 adenylate cyclase activating polypeptide 1 Rattus norvegicus 13-18 7593632-3 1995 Catecholamines are known to decrease the activity of LPL in adipocytes, and we have previously demonstrated that this inhibition occurs posttranscriptionally, with a prominent inhibition of LPL translation. Catecholamines 0-14 lipoprotein lipase Mus musculus 53-56 7491942-6 1995 These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release. Catecholamines 129-142 adenylate cyclase activating polypeptide 1 Rattus norvegicus 48-53 7491942-6 1995 These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release. Catecholamines 129-142 vasoactive intestinal peptide Rattus norvegicus 95-98 7491942-6 1995 These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release. Catecholamines 129-142 adenylate cyclase activating polypeptide 1 Rattus norvegicus 176-181 7491942-6 1995 These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release. Catecholamines 129-142 adenylate cyclase activating polypeptide 1 Rattus norvegicus 176-181 7491942-6 1995 These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release. Catecholamines 190-203 adenylate cyclase activating polypeptide 1 Rattus norvegicus 48-53 7491942-6 1995 These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release. Catecholamines 190-203 adenylate cyclase activating polypeptide 1 Rattus norvegicus 176-181 7491942-6 1995 These data led to the following conclusions: 1) PACAP was more potent than either carbachol or VIP in enhancing the secretion of catecholamine from the adrenal medulla, and 2) PACAP-induced catecholamine secretion was due to the direct action of PACAP on the adrenal medulla rather than an indirect action mediated by acetylcholine release. Catecholamines 190-203 adenylate cyclase activating polypeptide 1 Rattus norvegicus 176-181 8586028-0 1995 Involvement of brain catecholamines and acetylcholine in growth hormone hypersecretory states. Catecholamines 21-35 growth hormone 1 Homo sapiens 57-71 8586028-5 1995 In the cohort of brain neurotransmitters, catecholamines and acetylcholine reportedly play a major role in the control of neurosecretory GH-releasing hormone (GHRH) and somatostatin (SS)-producing neurons, and hence GH secretion. Catecholamines 42-56 growth hormone releasing hormone Homo sapiens 137-157 8586028-5 1995 In the cohort of brain neurotransmitters, catecholamines and acetylcholine reportedly play a major role in the control of neurosecretory GH-releasing hormone (GHRH) and somatostatin (SS)-producing neurons, and hence GH secretion. Catecholamines 42-56 growth hormone releasing hormone Homo sapiens 159-163 8586028-5 1995 In the cohort of brain neurotransmitters, catecholamines and acetylcholine reportedly play a major role in the control of neurosecretory GH-releasing hormone (GHRH) and somatostatin (SS)-producing neurons, and hence GH secretion. Catecholamines 42-56 somatostatin Homo sapiens 169-181 8586028-5 1995 In the cohort of brain neurotransmitters, catecholamines and acetylcholine reportedly play a major role in the control of neurosecretory GH-releasing hormone (GHRH) and somatostatin (SS)-producing neurons, and hence GH secretion. Catecholamines 42-56 growth hormone 1 Homo sapiens 137-139 8586028-8 1995 This review discusses the involvement of brain catecholamines and acetylcholine in GH hypersecretory states, including anorexia nervosa, acromegaly, IDDM, liver cirrhosis, depression, renal failure and GH insensitivity syndrome, with a view to providing a fuller understanding of their pathophysiology and, whenever possible, diagnostic and therapeutic implications. Catecholamines 47-61 growth hormone 1 Homo sapiens 83-85 7593632-3 1995 Catecholamines are known to decrease the activity of LPL in adipocytes, and we have previously demonstrated that this inhibition occurs posttranscriptionally, with a prominent inhibition of LPL translation. Catecholamines 0-14 lipoprotein lipase Mus musculus 190-193 8697051-1 1995 The control of fat cell lipolysis by the catecholamines involves at least four different adrenoceptor subtypes; three beta (beta 1-, beta 2-, and beta 3-ARs) and one alpha 2-adrenoceptor (alpha 2-AR). Catecholamines 41-55 adrenoceptor beta 1 Homo sapiens 124-156 7595477-2 1995 We have analyzed the expression of the neuronal promoter of the AADC gene in cells synthesizing catecholamines and serotonin, as well as in non-AADC-expressing cells. Catecholamines 96-110 dopa decarboxylase Rattus norvegicus 64-68 7595482-0 1995 Induction of gene expression of the catecholamine-synthesizing enzymes by insulin-like growth factor-I. Catecholamines 36-49 insulin like growth factor 1 Bos taurus 74-102 7595482-1 1995 The effects of insulin-like growth factor-I (IGF-I) on gene expression and the activities of the three enzymes specific for catecholamine biosynthesis, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT), were determined in bovine adrenomedullary chromaffin cells primary cultured in serum-free medium. Catecholamines 124-137 insulin like growth factor 1 Bos taurus 15-43 7595482-1 1995 The effects of insulin-like growth factor-I (IGF-I) on gene expression and the activities of the three enzymes specific for catecholamine biosynthesis, tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT), were determined in bovine adrenomedullary chromaffin cells primary cultured in serum-free medium. Catecholamines 124-137 insulin like growth factor 1 Bos taurus 45-50 8697051-8 1995 When considering differential beta-AR recruitment by catecholamines, it is the beta 1-AR which is always activated at the lowest norepinephrine levels, whatever the species, while the activation of the beta 3-AR requires higher norepinephrine levels. Catecholamines 53-67 adrenoceptor beta 1 Homo sapiens 79-88 8697051-5 1995 The affinity of the beta 3-AR for catecholamines is less than that of the classical beta 1- and beta 2-ARs in the various species investigated. Catecholamines 34-48 adrenoceptor beta 3 Homo sapiens 20-29 7586625-25 1995 Furthermore, these data suggest that the catabolic hormones (catecholamines, cortisol and glucagon), primarily glucagon seem to be involved in the modulation of IGF-I and IGFBP-1 levels following burn injury. Catecholamines 61-75 insulin like growth factor 1 Homo sapiens 161-166 7577928-11 1995 We propose a new model in which the pGlu of TRH binds to Asn289 in EL3 and conclude that, unlike catecholamines which bind completely within the transmembrane domain of their receptors, this tripeptide binds, at least in part, to the extracellular domain of its receptor. Catecholamines 97-111 thyrotropin releasing hormone Rattus norvegicus 44-47 7559551-1 1995 We reported recently that the gene that encodes tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is regulated by hypoxia in the dopaminergic cells of the mammalian carotid body (Czyzyk-Krzeska, M. F., Bayliss, D. A., Lawson, E. E. & Millhorn, D. E. (1992) J. Neurochem. Catecholamines 123-137 tyrosine hydroxylase Homo sapiens 48-68 7559551-1 1995 We reported recently that the gene that encodes tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, is regulated by hypoxia in the dopaminergic cells of the mammalian carotid body (Czyzyk-Krzeska, M. F., Bayliss, D. A., Lawson, E. E. & Millhorn, D. E. (1992) J. Neurochem. Catecholamines 123-137 tyrosine hydroxylase Homo sapiens 70-72 7586621-1 1995 OBJECTIVE: As part of a study on the effect of dopamine therapy on pituitary dependent hormone secretion in critical illness, we documented the impact of this inotropic and vasoactive catecholamine on the serum concentrations of dehydroepiandrosterone sulphate (DHEAS). Catecholamines 184-197 sulfotransferase family 2A member 1 Homo sapiens 262-267 7586625-25 1995 Furthermore, these data suggest that the catabolic hormones (catecholamines, cortisol and glucagon), primarily glucagon seem to be involved in the modulation of IGF-I and IGFBP-1 levels following burn injury. Catecholamines 61-75 insulin like growth factor binding protein 1 Homo sapiens 171-178 8588833-0 1995 Immunocytochemical localization of the catecholamine-synthesizing enzymes, tyrosine hydroxylase and dopamine-beta-hydroxylase, in the hypothalamus of cattle. Catecholamines 39-52 dopamine beta-hydroxylase Bos taurus 100-125 8563461-9 1995 As catecholamines antagonize insulin effects, one possible explanation for insulin resistance in amputees is hyperglycaemia-induced sympathoneural activation and a failure of hyperglycaemia to decrease adrenomedullary secretion. Catecholamines 3-17 insulin Homo sapiens 29-36 8563461-9 1995 As catecholamines antagonize insulin effects, one possible explanation for insulin resistance in amputees is hyperglycaemia-induced sympathoneural activation and a failure of hyperglycaemia to decrease adrenomedullary secretion. Catecholamines 3-17 insulin Homo sapiens 75-82 8568012-5 1995 Also, insulin can augment catecholamine release, increase vascular sensitivity to vasoconstrictor substances, and decrease vascular sensitivity to vasodilator substances. Catecholamines 26-39 insulin Homo sapiens 6-13 7557274-4 1995 Central and peripheral catecholamine-depleting agents, such as reserpine or alpha-methyl-p-tyrosine, exerted a more pronounced effect on renal ODC than the selective agents tetrabenazine or guanethidine. Catecholamines 23-36 ornithine decarboxylase, structural 1 Mus musculus 143-146 8535550-1 1995 The aim of the present study was to compare insulin sensitivity and catecholamine responses to insulin in lean, hypertensive (HT) and normotensive (NT) premenopausal women. Catecholamines 68-81 insulin Homo sapiens 95-102 7556639-2 1995 SNAP-25 occurs in neuroendocrine cells and, in analogy to its role in neurons, has been implicated in catecholamine secretion, yet the nature of the underlying mechanism remains obscure. Catecholamines 102-115 synaptosome associated protein 25 Homo sapiens 0-7 7556639-5 1995 Remarkably, a 20-mer synthetic peptide representing the sequence of the C-terminal domain of SNAP-25 blocked Ca(2+)-dependent catecholamine release with an IC50 = 20 microM. Catecholamines 126-139 synaptosome associated protein 25 Homo sapiens 93-100 7643107-3 1995 Here we report that histamine-H1 receptor activation induces redistribution of scinderin, a Ca(2+)-dependent F-actin severing protein, cortical F-actin disassembly, and catecholamine release. Catecholamines 169-182 histamine receptor H1 Homo sapiens 20-41 7593548-5 1995 The role of beta-adrenoceptors and endogenous catecholamines is further substantiated by the finding that pretreatment of animals with propranolol alone resulted in a dose-dependent increase of the TNF-alpha response induced by LPS, and that isoproterenol, a non-selective beta-adrenoceptor agonist, decreased it. Catecholamines 46-60 tumor necrosis factor Mus musculus 198-207 7593548-5 1995 The role of beta-adrenoceptors and endogenous catecholamines is further substantiated by the finding that pretreatment of animals with propranolol alone resulted in a dose-dependent increase of the TNF-alpha response induced by LPS, and that isoproterenol, a non-selective beta-adrenoceptor agonist, decreased it. Catecholamines 46-60 toll-like receptor 4 Mus musculus 228-231 7643128-0 1995 Pituitary adenylate cyclase-activating polypeptide (PACAP) regulation of sympathetic neuron neuropeptide Y and catecholamine expression. Catecholamines 111-124 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 7643128-0 1995 Pituitary adenylate cyclase-activating polypeptide (PACAP) regulation of sympathetic neuron neuropeptide Y and catecholamine expression. Catecholamines 111-124 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 7643128-1 1995 Two forms of pituitary adenylate cyclase-activating polypeptide (PACAP), the 38- and 27-amino-acid forms (PACAP38 and PACAP27, respectively), which share amino acid sequence homology with vasoactive intestinal peptide (VIP), were evaluated for their abilities to regulate sympathetic neuron catecholamine and neuropeptide Y (NPY) expression. Catecholamines 291-304 adenylate cyclase activating polypeptide 1 Homo sapiens 65-70 8521164-16 1995 Furthermore, as the beta 3-adrenoceptor activity correlates to the norepinephrine activity, more pronounced effects will be expected in catecholamine sensitive subjects. Catecholamines 136-149 adrenoceptor beta 3 Homo sapiens 20-39 7643128-2 1995 PACAP38 and PACAP27 potently and efficaciously stimulated NPY and catecholamine secretion in primary cultured superior cervical ganglion (SCG) neurons; 100- to 1,000-fold higher concentrations of VIP were required to modulate secretion, suggesting that SCG neurons express the PACAP-selective type I receptor. Catecholamines 66-79 adenylate cyclase activating polypeptide 1 Homo sapiens 0-5 7643128-5 1995 Sympathetic neuron NPY content was decreased, whereas cellular total catecholamine levels were elevated by the PACAP peptides; total NPY and catecholamine levels (secreted plus cellular content) were increased. Catecholamines 69-82 adenylate cyclase activating polypeptide 1 Homo sapiens 111-116 7643128-8 1995 SCG neuronal expression of mRNA encoding the type I PACAP receptor further supported the studies demonstrating that sympathetic neuronal levels of NPY and catecholamine content and secretion and mRNA are differentially regulated by the PACAP peptides. Catecholamines 155-168 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 7643128-8 1995 SCG neuronal expression of mRNA encoding the type I PACAP receptor further supported the studies demonstrating that sympathetic neuronal levels of NPY and catecholamine content and secretion and mRNA are differentially regulated by the PACAP peptides. Catecholamines 155-168 adenylate cyclase activating polypeptide 1 Homo sapiens 236-241 7653649-0 1995 Implication of L-type Ca2+ channels in noncholinergic adrenal catecholamine secretion by endothelin-1 in vivo. Catecholamines 62-75 endothelin 1 Canis lupus familiaris 89-101 7496795-1 1995 NPY is co-localised with catecholamines in the brain and periphery. Catecholamines 25-39 neuropeptide Y Rattus norvegicus 0-3 7653649-1 1995 The aim of the present study was to investigate if either dihydropyridine-sensitive L-type Ca2+ channels or cholinergic receptor-mediated mechanisms are implicated in endothelin-1 (ET)-induced adrenal catecholamine (CA) secretion in anesthetized dogs. Catecholamines 201-214 endothelin 1 Canis lupus familiaris 167-179 7653649-1 1995 The aim of the present study was to investigate if either dihydropyridine-sensitive L-type Ca2+ channels or cholinergic receptor-mediated mechanisms are implicated in endothelin-1 (ET)-induced adrenal catecholamine (CA) secretion in anesthetized dogs. Catecholamines 201-214 endothelin 1 Canis lupus familiaris 181-183 7648772-2 1995 Entacapone could potentiate the hemodynamic effects of exogenously administered catecholamines, which are substrates of the COMT enzyme. Catecholamines 80-94 catechol-O-methyltransferase Homo sapiens 124-128 7496035-9 1995 The number of catecholamine-positive cells which developed after 7 days in vitro in the presence of OP-1 was increased in a dose-dependent manner, with a greater than 100-fold maximal stimulation observed. Catecholamines 14-27 bone morphogenetic protein 7 Homo sapiens 100-104 7494448-3 1995 In this study we show that single and repeated injections of nicotine increase the expression of tyrosine hydroxylase (TH), a rate limiting enzyme in the catecholamine biosynthetic pathway. Catecholamines 154-167 tyrosine hydroxylase Rattus norvegicus 97-117 7494448-3 1995 In this study we show that single and repeated injections of nicotine increase the expression of tyrosine hydroxylase (TH), a rate limiting enzyme in the catecholamine biosynthetic pathway. Catecholamines 154-167 tyrosine hydroxylase Rattus norvegicus 119-121 7616202-2 1995 We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype. Catecholamines 176-189 phenylethanolamine-N-methyltransferase Mus musculus 51-89 7674267-2 1995 Thus, diuretics stimulate the renin angiotensin and catecholamine systems and, in some cases, vasopressin. Catecholamines 52-65 renin Homo sapiens 30-35 7496035-10 1995 The increase in the number of catecholamine-positive cells in the presence of OP-1 was paralleled by an increase in the number of tyrosine hydroxylase (TH)-positive cells. Catecholamines 30-43 bone morphogenetic protein 7 Homo sapiens 78-82 7629242-4 1995 To determine whether CRH was significantly involved in tonic as well as psychological stress-induced catecholamine levels in man, we infused 24 normal male undergraduate students with either saline (n = 12) or dexamethasone (DEX; n = 12) and evaluated their subsequent plasma levels of ACTH, cortisol, epinephrine (EPI), and not epinephrine (NEPI). Catecholamines 101-114 corticotropin releasing hormone Homo sapiens 21-24 7616202-2 1995 We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype. Catecholamines 176-189 phenylethanolamine-N-methyltransferase Mus musculus 91-95 7616202-2 1995 We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype. Catecholamines 176-189 dopamine beta-hydroxylase Homo sapiens 126-151 7616202-9 1995 These results strongly suggest that alteration of catecholamine specificity in the transgenic sympathetic neurons leads to regulated expression of the beta-AR subtypes in their target tissues. Catecholamines 50-63 adrenergic receptor, beta 1 Mus musculus 151-158 7477767-1 1995 Pancreastatin (PST), a 49 amino acid peptide originally isolated from porcine pancreas, is derived from chromogranin A (Cg A), an acidic protein co-released with catecholamines from sympathetic nerve terminals and chromaffin cells. Catecholamines 162-176 chromogranin A Homo sapiens 120-124 7543575-0 1995 Neuropeptide Y (18-36) modulates chromaffin cell catecholamine secretion by blocking the nicotinic receptor ion channel. Catecholamines 49-62 neuropeptide Y Bos taurus 0-14 8704732-3 1995 Since tuberoinfundibular dopaminergic (TIDA) neurons are involved in the negative regulation of PRL, we have also evaluated the effects of DHEA on the genetic expression of tyrosine hydroxylase (TH), the limiting enzyme in catecholamine biosynthesis in TIDA neurons. Catecholamines 223-236 tyrosine hydroxylase Rattus norvegicus 173-193 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 tyrosine hydroxylase Rattus norvegicus 113-133 7556372-9 1995 In the whole group of hypertensive patients (n = 26), partial correlations showed left ventricular mass index (LVMI) associated with fasting plasma insulin levels (r = 0.44 P < 0.005), insulin-mediated whole body glucose disposal (r = -0.41 P < 0.01) and nonoxidative glucose metabolism (r = -0.33 P < 0.04) independently of age, body weight, systolic blood pressure and plasma catecholamines levels. Catecholamines 387-401 insulin Homo sapiens 188-195 7635243-2 1995 Aromatic L-amino acid decarboxylase is the enzyme responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. Catecholamines 103-116 dopa decarboxylase Homo sapiens 0-35 8532850-11 1995 Clinical studies have been initiated for terminal cancer patients with promising results as assessed by markedly reduced narcotic intake, visual analog scale ratings, and increased CSF levels of catecholamines and met-enkephalin. Catecholamines 195-209 colony stimulating factor 2 Homo sapiens 181-184 7588884-2 1995 The rop gene product is homologous to the Caenorhabditis elegans UNC-18 and the rat munc-18/n-Sec1/rbSec1 proteins, implicated in the final steps of neurotransmitter exocytosis in nerve terminals, and the bovine mSec1 protein implicated in the secretion of catecholamines in chromaffin cells. Catecholamines 257-271 Ras opposite Drosophila melanogaster 4-7 7588884-2 1995 The rop gene product is homologous to the Caenorhabditis elegans UNC-18 and the rat munc-18/n-Sec1/rbSec1 proteins, implicated in the final steps of neurotransmitter exocytosis in nerve terminals, and the bovine mSec1 protein implicated in the secretion of catecholamines in chromaffin cells. Catecholamines 257-271 Putative acetylcholine regulator unc-18 Caenorhabditis elegans 65-71 7588884-2 1995 The rop gene product is homologous to the Caenorhabditis elegans UNC-18 and the rat munc-18/n-Sec1/rbSec1 proteins, implicated in the final steps of neurotransmitter exocytosis in nerve terminals, and the bovine mSec1 protein implicated in the secretion of catecholamines in chromaffin cells. Catecholamines 257-271 syntaxin binding protein 1 Rattus norvegicus 92-98 7588884-2 1995 The rop gene product is homologous to the Caenorhabditis elegans UNC-18 and the rat munc-18/n-Sec1/rbSec1 proteins, implicated in the final steps of neurotransmitter exocytosis in nerve terminals, and the bovine mSec1 protein implicated in the secretion of catecholamines in chromaffin cells. Catecholamines 257-271 syntaxin binding protein 1 Rattus norvegicus 99-105 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 dopamine beta-hydroxylase Rattus norvegicus 167-170 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 phenylethanolamine-N-methyltransferase Rattus norvegicus 176-214 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 phenylethanolamine-N-methyltransferase Rattus norvegicus 216-220 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 tyrosine hydroxylase Rattus norvegicus 135-137 7584561-1 1995 Local production of catecholamines in the stomach of the rat was studied by immunohistochemical demonstration of tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), the enzymes catalyzing the formation of dopamine, noradrenaline and adrenaline, respectively. Catecholamines 20-34 dopamine beta-hydroxylase Rattus norvegicus 140-165 7551967-0 1995 Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia. Catecholamines 105-118 tyrosine hydroxylase Homo sapiens 72-74 7790865-1 1995 Cell type-specific expression of the catecholamine synthetic enzyme, tyrosine hydroxylase (TH), appears to be mediated in part by cis-acting elements located at the 3" end of the human gene. Catecholamines 37-50 tyrosine hydroxylase Homo sapiens 69-89 7790865-1 1995 Cell type-specific expression of the catecholamine synthetic enzyme, tyrosine hydroxylase (TH), appears to be mediated in part by cis-acting elements located at the 3" end of the human gene. Catecholamines 37-50 tyrosine hydroxylase Homo sapiens 91-93 7616447-4 1995 These effects of NPFF were also observed, although attenuated, in catecholamine-depleted rats and in rats pretreated with a ganglionic blocking agent, hexamethonium (10 mg/kg, i.v.). Catecholamines 66-79 neuropeptide FF-amide peptide precursor Rattus norvegicus 17-21 7616447-14 1995 In addition, the present data show that the aforementioned NPFF-induced responses are also mediated by catecholamine-dependent mechanisms and suggest a functional interaction between adrenergic and NPFF systems. Catecholamines 103-116 neuropeptide FF-amide peptide precursor Rattus norvegicus 59-63 7616447-14 1995 In addition, the present data show that the aforementioned NPFF-induced responses are also mediated by catecholamine-dependent mechanisms and suggest a functional interaction between adrenergic and NPFF systems. Catecholamines 103-116 neuropeptide FF-amide peptide precursor Rattus norvegicus 198-202 7542701-2 1995 De novo transcription and translation of the CA biosynthetic enzyme, tyrosine hydroxylase (TH), was induced in striatal neurons exposed, simultaneously or sequentially, to the growth factor, acidic fibroblast growth factor (aFGF) and a catecholamine. Catecholamines 236-249 tyrosine hydroxylase Mus musculus 69-89 7542701-2 1995 De novo transcription and translation of the CA biosynthetic enzyme, tyrosine hydroxylase (TH), was induced in striatal neurons exposed, simultaneously or sequentially, to the growth factor, acidic fibroblast growth factor (aFGF) and a catecholamine. Catecholamines 236-249 tyrosine hydroxylase Mus musculus 91-93 7542701-2 1995 De novo transcription and translation of the CA biosynthetic enzyme, tyrosine hydroxylase (TH), was induced in striatal neurons exposed, simultaneously or sequentially, to the growth factor, acidic fibroblast growth factor (aFGF) and a catecholamine. Catecholamines 236-249 fibroblast growth factor 1 Mus musculus 224-228 7551967-4 1995 These results suggest that the polymorphic intron 1 of the human TH gene may be associated with disturbances of the catecholamine pathway in schizophrenia. Catecholamines 116-129 tyrosine hydroxylase Homo sapiens 65-67 7668357-5 1995 YAC and cosmid cloning results have further substantiated the close proximity of STP and a highly related sulfotransferase (STM), encoding the catecholamine-preferring enzyme, to the CLN3 region of chromosome 16p. Catecholamines 143-156 sulfotransferase family 1A member 1 Homo sapiens 81-84 7777510-1 1995 It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. Catecholamines 105-119 nuclear factor I/A Rattus norvegicus 48-65 7777510-1 1995 It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. Catecholamines 105-119 nuclear factor I/A Rattus norvegicus 67-70 7668357-5 1995 YAC and cosmid cloning results have further substantiated the close proximity of STP and a highly related sulfotransferase (STM), encoding the catecholamine-preferring enzyme, to the CLN3 region of chromosome 16p. Catecholamines 143-156 sulfotransferase family 1A member 3 Homo sapiens 124-127 7668357-5 1995 YAC and cosmid cloning results have further substantiated the close proximity of STP and a highly related sulfotransferase (STM), encoding the catecholamine-preferring enzyme, to the CLN3 region of chromosome 16p. Catecholamines 143-156 CLN3 lysosomal/endosomal transmembrane protein, battenin Homo sapiens 183-187 7611521-0 1995 Correlation between neural release of VIP and adrenomedullary catecholamine secretion in vivo. Catecholamines 62-75 vasoactive intestinal peptide Canis lupus familiaris 38-41 7611521-6 1995 The multiple linear regression analyses revealed that the net increases in adrenal venous catecholamine concentrations were strongly correlated with combined variables of VIP-ir concentration and frequencies, indicating r = 0.915 and 0.949 (n = 42, P < 0.0001) for epinephrine and norepinephrine concentrations, respectively. Catecholamines 90-103 vasoactive intestinal peptide Canis lupus familiaris 171-174 7673275-10 1995 The adverse effect of yohimbine and domperidone on lesion formation is probably mediated through the release of catecholamines, which subsequently act on the beta 2- and alpha 1-adrenoceptors respectively. Catecholamines 112-126 adrenoceptor beta 2 Rattus norvegicus 158-191 7743482-2 1995 The feasibility and clinical value of using the reverse transcriptase-(RT) polymerase chain reaction (PCR) to amplify mRNA for tyrosine hydroxylase (TH), the first enzyme of catecholamine synthesis, was evaluated to detect neuroblastoma cells in patient samples. Catecholamines 174-187 tyrosine hydroxylase Homo sapiens 127-147 7743482-2 1995 The feasibility and clinical value of using the reverse transcriptase-(RT) polymerase chain reaction (PCR) to amplify mRNA for tyrosine hydroxylase (TH), the first enzyme of catecholamine synthesis, was evaluated to detect neuroblastoma cells in patient samples. Catecholamines 174-187 tyrosine hydroxylase Homo sapiens 149-151 8529034-3 1995 The syndrome of complete dopamine-beta-hydroxylase deficiency with orthostatic hypotension and very high DA contributes to our understanding of the role of DA as a catecholamine with a peripheral biological action of its own. Catecholamines 164-177 dopamine beta-hydroxylase Homo sapiens 25-50 7539818-1 1995 The neuropeptide galanin (GAL) is widely distributed in the peripheral and central nervous systems, where it often coexists with catecholamines. Catecholamines 129-143 galanin and GMAP prepropeptide Homo sapiens 17-24 7539818-1 1995 The neuropeptide galanin (GAL) is widely distributed in the peripheral and central nervous systems, where it often coexists with catecholamines. Catecholamines 129-143 galanin and GMAP prepropeptide Homo sapiens 26-29 21153248-3 1995 We wondered if prolonged exposure to high concentrations of catecholamines might inhibit expression of the fatty acid synthase gene in fat cells. Catecholamines 60-74 fatty acid synthase Rattus norvegicus 107-126 21153248-10 1995 These results indicate that prolonged exposure to catecholamines, acting via beta adrenergic receptors, inhibit expression of the fatty acid synthase gene possibly by increasing intracellular concentrations of cAMP. Catecholamines 50-64 fatty acid synthase Rattus norvegicus 130-149 7611579-19 1995 The elevation of the plasma catecholamines immediately after SNP administration should also be taken into account, because an augmentation of the cAMP in various cell types has been proven to result in increased release of IL-6. Catecholamines 28-42 interleukin 6 Homo sapiens 223-227 7602797-4 1995 As a first step toward understanding the molecular mechanisms by which catecholamine synthesis is controlled in the tumor, we measured the levels of mRNA coding for the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH) and catecholamines in 6 pheochromocytomas and 2 normal adrenal glands. Catecholamines 71-84 tyrosine hydroxylase Homo sapiens 204-224 7602797-6 1995 There was a close correlation between the TH mRNA level and the catecholamines content in the tumors. Catecholamines 64-78 tyrosine hydroxylase Homo sapiens 42-44 7602797-9 1995 These findings indicate that catecholamine overproduction in pheochromocytomas is mediated by the overexpression of genes coding for catecholamines synthesizing enzymes, TH, DBH, and AADC. Catecholamines 29-42 tyrosine hydroxylase Homo sapiens 170-172 7602797-9 1995 These findings indicate that catecholamine overproduction in pheochromocytomas is mediated by the overexpression of genes coding for catecholamines synthesizing enzymes, TH, DBH, and AADC. Catecholamines 29-42 dopamine beta-hydroxylase Homo sapiens 174-177 7602797-9 1995 These findings indicate that catecholamine overproduction in pheochromocytomas is mediated by the overexpression of genes coding for catecholamines synthesizing enzymes, TH, DBH, and AADC. Catecholamines 29-42 dopa decarboxylase Homo sapiens 183-187 7602797-9 1995 These findings indicate that catecholamine overproduction in pheochromocytomas is mediated by the overexpression of genes coding for catecholamines synthesizing enzymes, TH, DBH, and AADC. Catecholamines 133-147 tyrosine hydroxylase Homo sapiens 170-172 7602797-9 1995 These findings indicate that catecholamine overproduction in pheochromocytomas is mediated by the overexpression of genes coding for catecholamines synthesizing enzymes, TH, DBH, and AADC. Catecholamines 133-147 dopa decarboxylase Homo sapiens 183-187 7644023-1 1995 The effect of catecholamine depletion or blockade of dopaminergic or noradrenergic receptors on the neuropeptide Y immunoreactivity was studied in the rat brain cortex using immunohistochemical methods. Catecholamines 14-27 pyroglutamylated RFamide peptide Rattus norvegicus 100-112 7545067-1 1995 Previous studies demonstrated that the cooperative interaction of acidic fibroblast growth factor (aFGF) and a partner molecule could induce the novel expression of the catecholamine (CA) biosynthetic enzyme, tyrosine hydroxylase (TH) in striatal neurons [Du and Iacovitti, J. Catecholamines 169-182 fibroblast growth factor 1 Homo sapiens 66-97 7545067-1 1995 Previous studies demonstrated that the cooperative interaction of acidic fibroblast growth factor (aFGF) and a partner molecule could induce the novel expression of the catecholamine (CA) biosynthetic enzyme, tyrosine hydroxylase (TH) in striatal neurons [Du and Iacovitti, J. Catecholamines 169-182 fibroblast growth factor 1 Homo sapiens 99-103 7545067-1 1995 Previous studies demonstrated that the cooperative interaction of acidic fibroblast growth factor (aFGF) and a partner molecule could induce the novel expression of the catecholamine (CA) biosynthetic enzyme, tyrosine hydroxylase (TH) in striatal neurons [Du and Iacovitti, J. Catecholamines 169-182 tyrosine hydroxylase Homo sapiens 209-229 7545067-1 1995 Previous studies demonstrated that the cooperative interaction of acidic fibroblast growth factor (aFGF) and a partner molecule could induce the novel expression of the catecholamine (CA) biosynthetic enzyme, tyrosine hydroxylase (TH) in striatal neurons [Du and Iacovitti, J. Catecholamines 169-182 tyrosine hydroxylase Homo sapiens 231-233 7477879-1 1995 Medullary catecholamine cell groups are involved in multiple modes of cardiovascular regulation and display indices of functional activation, including widespread c-fos expression, in response to hypotensive hemorrhage. Catecholamines 10-23 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 163-168 7551678-0 1995 Platelet-activating factor mediated potentiation of stimulation-evoked catecholamine release and the rise in intracellular free Ca2+ concentration in adrenal chromaffin cells. Catecholamines 71-84 PCNA-associated factor Bos taurus 0-26 7551678-1 1995 The effects of platelet-activating factor (PAF) on catecholamine (CA) release and intracellular free Ca2+ concentration ([Ca2+]i) were studied in cultured bovine adrenal chromaffin cells. Catecholamines 51-64 PCNA-associated factor Bos taurus 43-46 7617129-0 1995 Removal of adrenal steroids from the medium reverses the stimulating effect of catecholamines on corticotropin-releasing hormone neurons in organotypic cultures. Catecholamines 79-93 corticotropin releasing hormone Homo sapiens 97-128 7617129-1 1995 An organotypic culture system of anterior hypothalamic slices was developed for studying the secretory responses of corticotropin-releasing hormone (CRH) neurons to corticosteroid-catecholamine interactions. Catecholamines 180-193 corticotropin releasing hormone Homo sapiens 116-147 7617129-1 1995 An organotypic culture system of anterior hypothalamic slices was developed for studying the secretory responses of corticotropin-releasing hormone (CRH) neurons to corticosteroid-catecholamine interactions. Catecholamines 180-193 corticotropin releasing hormone Homo sapiens 149-152 7643912-6 1995 Inhibition of MAO reduced the deamination of dopamine and noradrenaline by 99.8% and 98.6%, respectively, indicating that MAO, and not SSAO, was responsible for deamination of the catecholamines in the lungs. Catecholamines 180-194 monoamine oxidase A Rattus norvegicus 14-17 7643912-6 1995 Inhibition of MAO reduced the deamination of dopamine and noradrenaline by 99.8% and 98.6%, respectively, indicating that MAO, and not SSAO, was responsible for deamination of the catecholamines in the lungs. Catecholamines 180-194 monoamine oxidase A Rattus norvegicus 122-125 7477880-11 1995 Double-labeling for tyrosine hydroxylase and Fos immunoreactivity showed that clonidine pretreatment greatly reduced the numbers of both catecholamine and non-catecholamine Fos-positive neurons. Catecholamines 137-150 proto-oncogene c-Fos Oryctolagus cuniculus 45-48 7618158-4 1995 Since DBH is an expression of catecholamine release, the relative increase in such activity could be envisaged as a compensatory mechanism to a reduced turnover rate as reflected by MAO-B activity. Catecholamines 30-43 dopamine beta-hydroxylase Homo sapiens 6-9 7618158-4 1995 Since DBH is an expression of catecholamine release, the relative increase in such activity could be envisaged as a compensatory mechanism to a reduced turnover rate as reflected by MAO-B activity. Catecholamines 30-43 monoamine oxidase B Homo sapiens 182-187 7621895-1 1995 The beta 3-adrenoceptor is a G protein-coupled receptor which mediates metabolic functions of the endogenous catecholamines epinephrine and norepinephrine. Catecholamines 109-123 adrenoceptor beta 3 Homo sapiens 4-23 7624029-4 1995 Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines. Catecholamines 370-384 adenylate cyclase activating polypeptide 1 Rattus norvegicus 5-10 7624029-1 1995 The neurotransmitter, pituitary adenylate cyclase-activating polypeptide (PACAP), is present in the rat adrenal medulla and is a potent stimulus for catecholamine secretion. Catecholamines 149-162 adenylate cyclase activating polypeptide 1 Rattus norvegicus 22-72 7624029-4 1995 Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines. Catecholamines 370-384 adenylate cyclase activating polypeptide 1 Rattus norvegicus 18-23 7624029-1 1995 The neurotransmitter, pituitary adenylate cyclase-activating polypeptide (PACAP), is present in the rat adrenal medulla and is a potent stimulus for catecholamine secretion. Catecholamines 149-162 adenylate cyclase activating polypeptide 1 Rattus norvegicus 74-79 7624029-4 1995 Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines. Catecholamines 370-384 adenylate cyclase activating polypeptide 1 Rattus norvegicus 18-23 7703232-6 1995 S-COMT showed about 15 times higher Km values for catecholamines than MB-COMT. Catecholamines 50-64 catechol-O-methyltransferase Homo sapiens 2-6 7715703-0 1995 Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Catecholamines 66-80 tyrosine hydroxylase Mus musculus 27-47 7715703-1 1995 Tyrosine hydroxylase catalyses the initial, rate-limiting step in the catecholamine biosynthetic pathway. Catecholamines 70-83 tyrosine hydroxylase Mus musculus 0-20 7717451-5 1995 A subpopulation of neuroblastomas expressed IGF2, which correlated with an early age at diagnosis, an extra-adrenal tumor origin, and severe hemodynamic signs of catecholamine secretion. Catecholamines 162-175 insulin like growth factor 2 Homo sapiens 44-48 7733246-1 1995 A recently discovered endogenous autacoid, C-type natriuretic peptide, was tested in a pheochromocytoma (PC12) cell line for effects on 1) catecholamine release induced by a depolarizing stimulus, 2) guanylyl and adenylyl cyclase activities, and 3) specific 125I-labeled atrial natriuretic peptide (ANP) binding. Catecholamines 139-152 natriuretic peptide C Rattus norvegicus 43-69 7608329-1 1995 The objectives of the present study were 1) to utilize Fos immunohistochemistry as a marker for neuronal activity in order to examine the population of neurons in the medulla that is engaged by activation of nociceptive peripheral afferents and 2) to determine whether catecholamine-containing neurons in the medulla also express noxious heat-evoked Fos-like immunoreactivity. Catecholamines 269-282 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 55-58 7608329-4 1995 Increased numbers of Fos-positive neurons also were observed in both the ipsilateral and the contralateral A1 catecholamine cell groups. Catecholamines 110-123 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 21-24 8574778-4 1995 Since both ANG II and ANG III have a physiological role on catecholamine metabolism, these peptides could modulate the adrenal medulla functions. Catecholamines 59-72 angiotensinogen Rattus norvegicus 11-17 8574778-4 1995 Since both ANG II and ANG III have a physiological role on catecholamine metabolism, these peptides could modulate the adrenal medulla functions. Catecholamines 59-72 angiogenin Rattus norvegicus 11-14 8574778-7 1995 The interaction between ANF and the renin-angiotensin system could contribute to the regulation of the adrenal medulla catecholamines pathway and sympathetic activity. Catecholamines 119-133 natriuretic peptide A Rattus norvegicus 24-27 7543184-9 1995 While the NPY(16-36)-induced inhibition of IACh was reversed on washout of the peptide, the slightly shorter C-terminal fragment NPY(18-36) caused a long-lasting depression of both IACh and catecholamine secretion evoked by nicotine. Catecholamines 190-203 neuropeptide Y Bos taurus 129-132 7620295-1 1995 Neuropeptide Y, a potent vasoconstrictor peptide with 36 amino acid residues, is co-stored and released with catecholamines in sympathetic nerve endings. Catecholamines 109-123 neuropeptide Y Homo sapiens 0-14 7735898-2 1995 In addition, dopamine beta-hydroxylase (DBH) and tyrosine hydroxylase (TH), two enzymes involved in catecholamine synthesis, were localized immunohistochemically to delineate hepatic sympathetic nerve fibres. Catecholamines 100-113 tyrosine hydroxylase Homo sapiens 71-73 7671188-1 1995 The aim of the present study was to investigate whether a novel nonpeptide AT1 selective antagonist, BMS 186295 (BMS), can antagonize adrenal catecholamine release induced by local administration of angiotensin II (AII) in anesthetized dogs. Catecholamines 142-155 angiotensin II receptor type 1 Canis lupus familiaris 75-78 7613527-1 1995 To study the effect of chronic exposure to elevated plasma catecholamines on surface beta 2-adrenoceptor density, we measured these receptors in the lymphocytes of 9 patients with pheochromocytoma as well as in 27 healthy control subjects. Catecholamines 59-73 adrenoceptor beta 2 Homo sapiens 85-104 7613527-6 1995 We conclude that chronic catecholamine excess induces a decrease of lymphocyte beta 2-adrenoceptor surface number and response that is reversible upon normalization of plasma catecholamine levels. Catecholamines 25-38 adrenoceptor beta 2 Homo sapiens 79-98 7613527-6 1995 We conclude that chronic catecholamine excess induces a decrease of lymphocyte beta 2-adrenoceptor surface number and response that is reversible upon normalization of plasma catecholamine levels. Catecholamines 175-188 adrenoceptor beta 2 Homo sapiens 79-98 7543184-12 1995 It appears that, by activating Y3-receptors, NPY inhibits nAChR-current and the resulting secretion of catecholamines from bovine chromaffin cells. Catecholamines 103-117 neuropeptide Y Bos taurus 45-48 7890648-3 1995 Results from classic depolarizing stimuli, high potassium (30-140 mM) and 1,1-dimethyl-4-phenylpiperazinium (3-50 microM), show a dependence of peak cytosolic Ca2+ concentration and catecholamine release on secretagogue concentration. Catecholamines 182-195 carbonic anhydrase 2 Bos taurus 159-162 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 catechol-O-methyltransferase Rattus norvegicus 215-243 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 catechol-O-methyltransferase Rattus norvegicus 245-249 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 monoamine oxidase A Rattus norvegicus 255-272 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 monoamine oxidase A Rattus norvegicus 274-277 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 catechol-O-methyltransferase Rattus norvegicus 337-341 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Catecholamines 60-74 monoamine oxidase A Rattus norvegicus 346-349 7781689-4 1995 However, if the catecholamine neuronal uptake blocker cocaine was added to the tissue bath, neuropeptide Y induced a contraction which could be fully blocked by prazosin (1000 nM). Catecholamines 16-29 neuropeptide Y Rattus norvegicus 92-106 7890648-9 1995 Taken together, these results show that exocytosis of catecholamines can be induced by an increase in cytosolic Ca2+ either as a result of transmembrane entry or by release of internal stores. Catecholamines 54-68 carbonic anhydrase 2 Bos taurus 112-115 7887448-4 1995 Diffuse and membrane staining of c-ErbB2 was well correlated with high urinary catecholamine secretion. Catecholamines 79-92 erb-b2 receptor tyrosine kinase 2 Mus musculus 33-40 7535011-1 1995 Previous studies demonstrated that catecholamines modulate the phosphaturic response to parathyroid hormone (PTH) in normal rats. Catecholamines 35-49 parathyroid hormone Rattus norvegicus 88-107 7867187-2 1995 BACKGROUND: Angiotensin II (Ang II) facilitates adrenergic neurotransmission in normotensive and hypertensive subjects, whereas angiotensin-converting enzyme inhibitors have been shown to depress circulating catecholamine concentrations in some studies. Catecholamines 208-221 angiotensinogen Homo sapiens 12-26 7867187-2 1995 BACKGROUND: Angiotensin II (Ang II) facilitates adrenergic neurotransmission in normotensive and hypertensive subjects, whereas angiotensin-converting enzyme inhibitors have been shown to depress circulating catecholamine concentrations in some studies. Catecholamines 208-221 angiotensinogen Homo sapiens 28-34 7835334-8 1995 Furthermore, Ca2+ concentrations which trigger catecholamine secretion acted to prevent the leakage of NSF and alpha-SNAP from permeabilized cells. Catecholamines 47-60 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 103-106 7535224-0 1995 Catecholaminergic function and P300 amplitude in major depressive disorder (P300 and catecholamines). Catecholamines 85-99 E1A binding protein p300 Homo sapiens 31-35 7790611-2 1995 We refer to a patient with a brain stem compression after head injury, who developed a profound hypokalemia (K+ = 1.2 mmol/l) with life-threatening arrhythmias, probably due to a catecholamine induced intracellular potassium shift (beta-2-stimulation). Catecholamines 179-192 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 232-238 7883959-12 1995 In conclusion, catecholamine-induced rate of FFA mobilization from omental fat cells is accelerated due to elevated rate of lipolysis in obesity, mainly because of an increased beta 3-adrenoceptor function, but partly also because of a decreased alpha 2-adrenoceptor function. Catecholamines 15-28 adrenoceptor beta 3 Homo sapiens 177-196 7744305-2 1995 This study explored the possible interaction between the two molecules: the effects of acetylcholinesterase on the autoxidation of the catecholamine were tested, and, in turn, modification of the catalytic activity of the enzyme by products of dopamine oxidation were studied. Catecholamines 135-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 7599533-1 1995 Levels of catecholamines and the synthesizing enzyme, tyrosine hydroxylase (TH) are markedly decreased in the dorsal striatum, caudate-putamen nuclei, following neurotoxic lesions with 6-hydroxy-dopamine (6-OHDA). Catecholamines 10-24 tyrosine hydroxylase Rattus norvegicus 54-74 7599533-1 1995 Levels of catecholamines and the synthesizing enzyme, tyrosine hydroxylase (TH) are markedly decreased in the dorsal striatum, caudate-putamen nuclei, following neurotoxic lesions with 6-hydroxy-dopamine (6-OHDA). Catecholamines 10-24 tyrosine hydroxylase Rattus norvegicus 76-78 7861137-6 1995 Like the patch-clamp studies, secretion experiments demonstrated that both CNP and C-ANF are equally effective in reducing nicotine-evoked catecholamine secretion by cultured chromaffin cells, raising the possibility that the effect of CNP is predominantly mediated by the ANF-R2 and not the ANF-R1C receptors. Catecholamines 139-152 natriuretic peptide A Bos taurus 85-88 7617303-6 1995 The results suggest that postsynaptic dendritic spines and astrocytic processes may be the sites of catecholamine inactivation by COMT in rat brain. Catecholamines 100-113 catechol-O-methyltransferase Rattus norvegicus 130-134 7726391-3 1995 TH is the rate-limiting enzyme in catecholamine biosynthesis and reflects noradrenergic differentiation. Catecholamines 34-47 tyrosine hydroxylase Bos taurus 0-2 7858743-9 1995 We conclude that HA-induced secretion of POMC-derived peptides from the anterior and intermediate lobe of the pituitary gland and of PRL from the anterior lobe is, at least in part, mediated via catecholamines. Catecholamines 195-209 proopiomelanocortin Rattus norvegicus 41-45 7739100-4 1995 Platelet activation by contact with tissue collagen or thrombin results in the release of catecholamine concentrated in the dense body. Catecholamines 90-103 coagulation factor II, thrombin Homo sapiens 55-63 7721981-5 1995 as revealed with immunocytochemical techniques, with antibodies raised against three synthetic enzymes of the catecholamine (CA) pathway: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 110-123 dopamine beta-hydroxylase Homo sapiens 165-190 7721981-5 1995 as revealed with immunocytochemical techniques, with antibodies raised against three synthetic enzymes of the catecholamine (CA) pathway: tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 110-123 dopamine beta-hydroxylase Homo sapiens 192-195 7836399-3 1995 Subcellular fractionation demonstrates that a substantial amount of the VAMP-2 (24-36%) is associated with dense core, catecholamine-containing granules (DCGs). Catecholamines 119-132 vesicle-associated membrane protein 2 Rattus norvegicus 72-78 7835334-8 1995 Furthermore, Ca2+ concentrations which trigger catecholamine secretion acted to prevent the leakage of NSF and alpha-SNAP from permeabilized cells. Catecholamines 47-60 NSF attachment protein alpha Homo sapiens 111-121 7819204-1 1995 Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis. Catecholamines 52-65 tyrosine hydroxylase Rattus norvegicus 0-20 8572926-7 1995 The determination of plasma DBH activity could be a marker to monitor the effect of thiram on catecholamine metabolism in occupationally exposed workers but not that of disulfiram in abstinent alcoholics. Catecholamines 94-107 dopamine beta-hydroxylase Rattus norvegicus 28-31 7771182-6 1995 Therefore, different from our current knowledge in rats COMT and MAOX either co-operate in catecholamine degradation or they degrade the respective catecholamines alone. Catecholamines 91-104 catechol-O-methyltransferase Rattus norvegicus 56-60 7771182-6 1995 Therefore, different from our current knowledge in rats COMT and MAOX either co-operate in catecholamine degradation or they degrade the respective catecholamines alone. Catecholamines 148-162 catechol-O-methyltransferase Rattus norvegicus 56-60 7660756-4 1995 Furthermore, in double-labeling studies, it was demonstrated that a large percentage of the vagally innervated glomus cells were capable of catecholamine synthesis on the basis of their positive staining for tyrosine hydroxylase antibody. Catecholamines 140-153 tyrosine hydroxylase Rattus norvegicus 208-228 7484438-11 1995 Earlier studies showed that catecholamines release Ang II from neurons and not from glia involving alpha 2 receptor blockade to increase norepinephrine by inhibiting reuptake (7). Catecholamines 28-42 angiogenin Rattus norvegicus 51-54 7840338-0 1995 Hepatic denervation reduces adrenal catecholamine secretion during insulin-induced hypoglycemia. Catecholamines 36-49 insulin Canis lupus familiaris 67-74 7840338-4 1995 The catecholamine output from the adrenal glands in the sham group significantly increased (P < 0.05), reaching a maximum level 45 min after insulin injection from a control value for epinephrine of 86.35 +/- 26.65 ng/min and for norepinephrine of 32.14 +/- 11.68 ng/min to 659.03 +/- 269.39 and 181.21 +/- 63.03 ng/min, respectively. Catecholamines 4-17 insulin Canis lupus familiaris 144-151 7840338-5 1995 By contrast, however, adrenal catecholamine output increased only slightly in the hepatic-denervated group during insulin-induced hypoglycemia, from 148.37 +/- 95.29 and 52.06 +/- 28.05 ng/min to 210.49 +/- 96.09 and 79.61 +/- 26.11 ng/min for epinephrine and norepinephrine, respectively, the difference being statistically nonsignificant compared with the corresponding preinjection control value. Catecholamines 30-43 insulin Canis lupus familiaris 114-121 7496819-2 1995 The combined retrograde tracing/immunohistochemical method was used to test for the presence of catecholamines and neuropeptide Y (NPY) in ventrolateral medulla neurons that innervate the CeA. Catecholamines 96-110 carcinoembryonic antigen gene family 4 Rattus norvegicus 188-191 7496819-8 1995 The high percentage of double-labeled NPY-immunoreactive neurons suggests NPY is colocalized in CeA-projecting catecholamine neurons, indicating that input from the ventrolateral medulla to the CeA primarily arises from C1 adrenergic neurons that also express NPY. Catecholamines 111-124 neuropeptide Y Rattus norvegicus 74-77 7496819-8 1995 The high percentage of double-labeled NPY-immunoreactive neurons suggests NPY is colocalized in CeA-projecting catecholamine neurons, indicating that input from the ventrolateral medulla to the CeA primarily arises from C1 adrenergic neurons that also express NPY. Catecholamines 111-124 carcinoembryonic antigen gene family 4 Rattus norvegicus 96-99 7633891-0 1995 Vasopressin and oxytocin gene expression in intact rats and under catecholamine deficiency during ontogenesis. Catecholamines 66-79 arginine vasopressin Rattus norvegicus 0-11 7496819-8 1995 The high percentage of double-labeled NPY-immunoreactive neurons suggests NPY is colocalized in CeA-projecting catecholamine neurons, indicating that input from the ventrolateral medulla to the CeA primarily arises from C1 adrenergic neurons that also express NPY. Catecholamines 111-124 neuropeptide Y Rattus norvegicus 74-77 7576974-6 1995 Furthermore, an inverse correlation of noradrenaline transporter and tyrosine hydroxylase gene expression, the key regulatory enzyme of catecholamine synthesis, was observed. Catecholamines 136-149 solute carrier family 6 member 2 Homo sapiens 39-64 7735274-0 1995 Interactions of angiotensin II with central catecholamines. Catecholamines 44-58 angiotensinogen Homo sapiens 16-30 7557818-7 1995 Activation of this vascular beta 3-adrenoceptor requires higher doses of catecholamines than for beta 1- or beta 2-adrenoceptors. Catecholamines 73-87 adrenoceptor beta 3 Homo sapiens 28-47 7553077-7 1995 Altered membrane lipid composition and increased levels of free fatty acids; 2. long-lasting hyperinsulinemia; 3. increased plasma levels of insulin counteracting hormones such as growth hormone, glucagon, catecholamines and possibly cytokines; 4. a lack of liver-derived humoral factors with insulin-like activity, i.e. insulin-like growth factors I and II. Catecholamines 206-220 insulin Homo sapiens 141-148 7553079-0 1995 Enhanced cAMP production mediates the stimulatory action of pituitary adenylate cyclase activating polypeptide (PACAP) on in vitro catecholamine secretion from bovine adrenal chromaffin cells. Catecholamines 131-144 adenylate cyclase activating polypeptide 1 Bos taurus 60-118 7553079-1 1995 The 38 amino acid peptide pituitary adenylate cyclase activating polypeptide (PACAP) induced a dose dependent increase of catecholamine secretion in cultures of bovine chromaffin cells. Catecholamines 122-135 adenylate cyclase activating polypeptide 1 Bos taurus 26-76 7628838-1 1995 Catecholamines (adrenaline and noradrenaline) stimulate adipocyte lipolysis via three beta-adrenoceptor subtypes beta 1, beta 2 and beta 3. Catecholamines 0-14 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 113-119 7628838-1 1995 Catecholamines (adrenaline and noradrenaline) stimulate adipocyte lipolysis via three beta-adrenoceptor subtypes beta 1, beta 2 and beta 3. Catecholamines 0-14 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 121-138 7628838-17 1995 From these observations, it could be hypothesized that the beta 3-adrenoceptor, that shows a low affinity for catecholamines, is the "emergency" beta-adrenoceptor which is essential under conditions of strong and sustained sympathetic nervous system activation. Catecholamines 110-124 adrenoceptor beta 3 Homo sapiens 59-78 7843740-9 1995 Our data may be important in understanding the molecular mechanism(s) of the stimulatory effect of catecholamines/glucocorticoid-induced expression of the angiotensinogen gene in the liver. Catecholamines 99-113 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 155-170 7768322-5 1995 The abundance of PACAP and its type I receptors in the adrenal medulla and the results of studies with synthetic PACAP suggest that PACAP is a potent noncholinergic secretogue for catecholamines. Catecholamines 180-194 adenylate cyclase activating polypeptide 1 Homo sapiens 17-22 7768322-5 1995 The abundance of PACAP and its type I receptors in the adrenal medulla and the results of studies with synthetic PACAP suggest that PACAP is a potent noncholinergic secretogue for catecholamines. Catecholamines 180-194 adenylate cyclase activating polypeptide 1 Homo sapiens 113-118 7768322-5 1995 The abundance of PACAP and its type I receptors in the adrenal medulla and the results of studies with synthetic PACAP suggest that PACAP is a potent noncholinergic secretogue for catecholamines. Catecholamines 180-194 adenylate cyclase activating polypeptide 1 Homo sapiens 113-118 7553079-1 1995 The 38 amino acid peptide pituitary adenylate cyclase activating polypeptide (PACAP) induced a dose dependent increase of catecholamine secretion in cultures of bovine chromaffin cells. Catecholamines 122-135 adenylate cyclase activating polypeptide 1 Bos taurus 78-83 7553079-4 1995 Preincubation of cells with 1 nM PACAP for 5 min facilitated the subsequent nicotine stimulated catecholamine secretion during a 20 min incubation without addition of the peptide. Catecholamines 96-109 adenylate cyclase activating polypeptide 1 Bos taurus 33-38 7553079-5 1995 PACAP induced catecholamine secretion was clearly accompanied by a dose dependent increase of intracellular cAMP concentrations. Catecholamines 14-27 adenylate cyclase activating polypeptide 1 Bos taurus 0-5 7553079-6 1995 The percentage of cells responding to PACAP with increased catecholamine secretion was assessed by immunocytochemistry of the transient appearance of dopamine-beta-hydroxylase, associated with the membranes of the chromaffin granules on the cell surface during the secretory process. Catecholamines 59-72 adenylate cyclase activating polypeptide 1 Bos taurus 38-43 7553079-6 1995 The percentage of cells responding to PACAP with increased catecholamine secretion was assessed by immunocytochemistry of the transient appearance of dopamine-beta-hydroxylase, associated with the membranes of the chromaffin granules on the cell surface during the secretory process. Catecholamines 59-72 dopamine beta-hydroxylase Bos taurus 150-175 7553079-8 1995 Though PACAP stimulated catecholamine secretion, we did not observed major effects on intracellular free calcium concentrations ([Ca2+]i) as determined with fura-2 by single cell fluorescence microscopy. Catecholamines 24-37 adenylate cyclase activating polypeptide 1 Bos taurus 7-12 7553079-11 1995 These data indicate that the stimulatory action of PACAP on in vitro catecholamine secretion from bovine chromaffin cells is linked to a rise of intracellular cAMP. Catecholamines 69-82 adenylate cyclase activating polypeptide 1 Bos taurus 51-56 7744361-3 1995 Cell bodies of CRH neurons exist in the paraventricular nucleus (PVN) which receives neuropeptide Y (NPY) containing neurons of two different origins: one from the brainstem, in which catecholamine (CA) coexists, and the other from the arcuate nucleus (ARC). Catecholamines 184-197 corticotropin releasing hormone Rattus norvegicus 15-18 7721260-7 1995 Reportedly, catecholamines induce GH release by stimulating GHRH neurons and inhibiting somatostatin-releasing neurons; acetylcholine stimulates GH release via muscarinic receptors, in this way inhibiting the action of somatostatin neurons. Catecholamines 12-26 growth hormone releasing hormone Rattus norvegicus 60-64 7721260-7 1995 Reportedly, catecholamines induce GH release by stimulating GHRH neurons and inhibiting somatostatin-releasing neurons; acetylcholine stimulates GH release via muscarinic receptors, in this way inhibiting the action of somatostatin neurons. Catecholamines 12-26 somatostatin Rattus norvegicus 88-100 8821055-0 1995 Exogenous stimulation of NGF synthesis by catecholamines and their analogues. Catecholamines 42-56 nerve growth factor Homo sapiens 25-28 8821055-3 1995 For various compounds, especially catecholamines and their analogues, it has been demonstrated that induction of synthesis of NGF in glial and neuronal cells is possible. Catecholamines 34-48 nerve growth factor Homo sapiens 126-129 7823760-6 1995 The hypothesis is advanced that adrenal medulla plays a pivotal role in the mechanism(s) underlying the adrenocortical secretagogue action of PACAP, being mineralocorticoid and glucocorticoid responses probably mediated by the release by chromaffin cells of catecholamine and ACTH or exclusively ACTH, respectively. Catecholamines 258-271 adenylate cyclase activating polypeptide 1 Rattus norvegicus 142-147 8788067-1 1995 GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively. Catecholamines 224-238 GTP cyclohydrolase 1 Mus musculus 0-20 8788067-1 1995 GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively. Catecholamines 224-238 GTP cyclohydrolase 1 Mus musculus 22-25 7564901-1 1995 The effect of bradykinin (BK), in the presence of ouabain, an inhibitor of Na(+)-K+ ATPase, on catecholamine (CA) secretion was studied in cultured bovine adrenal chromaffin cells, to determine whether Na+, as well as Ca2+, is involved in BK-receptor mediated CA secretion. Catecholamines 95-108 kininogen 1 Bos taurus 14-24 7564901-1 1995 The effect of bradykinin (BK), in the presence of ouabain, an inhibitor of Na(+)-K+ ATPase, on catecholamine (CA) secretion was studied in cultured bovine adrenal chromaffin cells, to determine whether Na+, as well as Ca2+, is involved in BK-receptor mediated CA secretion. Catecholamines 95-108 kininogen 1 Bos taurus 26-28 7564901-0 1995 Potentiation by ouabain of bradykinin-induced catecholamine secretion and calcium influx into cultured bovine adrenal chromaffin cells: evidence for involvement of Na+ influx associated with the bradykinin B2-receptor. Catecholamines 46-59 kininogen 1 Bos taurus 27-37 7564902-1 1995 In response to biochemical factors like catecholamines, bradykinins, histamine and physical factors like shear stress, endothelial cells release a non prostanoid factor, called endothelium derived relaxing factor (EDRF), which relaxes vascular smooth muscle. Catecholamines 40-54 alpha hemoglobin stabilizing protein Homo sapiens 177-212 7564902-1 1995 In response to biochemical factors like catecholamines, bradykinins, histamine and physical factors like shear stress, endothelial cells release a non prostanoid factor, called endothelium derived relaxing factor (EDRF), which relaxes vascular smooth muscle. Catecholamines 40-54 alpha hemoglobin stabilizing protein Homo sapiens 214-218 7540295-4 1995 These findings suggest that the mechanism underlying the aldosterone secretagogue action of SP probably involves the stimulation of catecholamine release by adrenal medulla chromaffin cells. Catecholamines 132-145 surfactant protein A1 Rattus norvegicus 92-94 8728769-0 1995 [Inactivation of the myocardial lipoamide dehydrogenase by catecholamines. Catecholamines 59-73 dihydrolipoamide dehydrogenase Homo sapiens 32-55 8728769-2 1995 Inactivation of lipoamide dehydrogenase (LipDH) by the Cu(II)/H2O2 Fenton system (SF-Cu(II): (5.0 microM Cu(II), 3.0 mM H2O2) was enhanced by catecholamines (CAs), namely, epinephrine, levoDOPA (DOPA), DOPAMINE, 6-hydroxyDOPAMINE (OH-DOPAMINE) and related compounds (DOPAC, CATECHOL, etc.). Catecholamines 142-156 dihydrolipoamide dehydrogenase Homo sapiens 16-39 8728769-2 1995 Inactivation of lipoamide dehydrogenase (LipDH) by the Cu(II)/H2O2 Fenton system (SF-Cu(II): (5.0 microM Cu(II), 3.0 mM H2O2) was enhanced by catecholamines (CAs), namely, epinephrine, levoDOPA (DOPA), DOPAMINE, 6-hydroxyDOPAMINE (OH-DOPAMINE) and related compounds (DOPAC, CATECHOL, etc.). Catecholamines 158-161 dihydrolipoamide dehydrogenase Homo sapiens 16-39 7731501-7 1995 They suggest that variations in the levels of circulating NPY or in the release of NPY by the chromaffin cells themselves (in autocrine and/or paracrine way) can increase the biosynthesis of catecholamines in rat adrenals. Catecholamines 191-205 neuropeptide Y Rattus norvegicus 58-61 7731501-7 1995 They suggest that variations in the levels of circulating NPY or in the release of NPY by the chromaffin cells themselves (in autocrine and/or paracrine way) can increase the biosynthesis of catecholamines in rat adrenals. Catecholamines 191-205 neuropeptide Y Rattus norvegicus 83-86 8584678-1 1995 Aromatic L-amino acid decarboxylase (AAAD) is the second enzyme in the sequence leading to the synthesis of the catecholamines and serotonin, and it is the rate-limiting enzyme for the synthesis of the trace amines. Catecholamines 112-126 dopa decarboxylase Homo sapiens 0-35 7700724-1 1995 Chromogranin A (CGA), a large acidic 48-kD protein, costored and coreleased by exocytosis with catecholamines, has been shown to be a precursor of peptides that exert feedback regulatory control on catecholamine secretion. Catecholamines 95-109 chromogranin A Homo sapiens 0-14 7700724-1 1995 Chromogranin A (CGA), a large acidic 48-kD protein, costored and coreleased by exocytosis with catecholamines, has been shown to be a precursor of peptides that exert feedback regulatory control on catecholamine secretion. Catecholamines 95-109 chromogranin A Homo sapiens 16-19 7700724-1 1995 Chromogranin A (CGA), a large acidic 48-kD protein, costored and coreleased by exocytosis with catecholamines, has been shown to be a precursor of peptides that exert feedback regulatory control on catecholamine secretion. Catecholamines 95-108 chromogranin A Homo sapiens 0-14 7700724-1 1995 Chromogranin A (CGA), a large acidic 48-kD protein, costored and coreleased by exocytosis with catecholamines, has been shown to be a precursor of peptides that exert feedback regulatory control on catecholamine secretion. Catecholamines 95-108 chromogranin A Homo sapiens 16-19 7700724-2 1995 In plasma, CGA levels increase in response to a large-amplitude physical stimulation in adult subjects and may be related to catecholamine levels. Catecholamines 125-138 chromogranin A Homo sapiens 11-14 7700724-5 1995 The aim of our study was to determine CGA plasma levels in infants delivered vaginally or by elective cesarean section and to investigate the possible correlation between CGA and catecholamine concentrations. Catecholamines 179-192 chromogranin A Homo sapiens 171-174 8532586-3 1995 In comparison with adjacent sections stained with antisera to catecholamine synthesizing enzymes, PACAP-positive cells were immunoreactive to tyrosine hydroxylase and dopamine beta-hydroxylase, but not to phenylethanolamine-N-methyltransferase, suggesting that they were coincident with noradrenaline secreting cells. Catecholamines 62-75 adenylate cyclase activating polypeptide 1 Rattus norvegicus 98-103 8532586-7 1995 It was suggested that PACAP would localize in the cytoplasmic matrix of noradrenaline cells and stimulate the catecholamine synthesis and release in the adrenal medulla. Catecholamines 110-123 adenylate cyclase activating polypeptide 1 Rattus norvegicus 22-27 8584678-1 1995 Aromatic L-amino acid decarboxylase (AAAD) is the second enzyme in the sequence leading to the synthesis of the catecholamines and serotonin, and it is the rate-limiting enzyme for the synthesis of the trace amines. Catecholamines 112-126 dopa decarboxylase Homo sapiens 37-41 7715798-3 1994 Polyclonal antisera directed towards phenylethanolamine N-methyltransferase (PNMT) and tyrosine hydroxylase (TH), biosynthetic enzymes of catecholamines, were used for the simultaneous immunocytochemical detection of adrenergic fibers and TIDA neurons, respectively, in Vibratome sections of the rat hypothalamus. Catecholamines 138-152 phenylethanolamine-N-methyltransferase Rattus norvegicus 37-75 7810621-0 1994 Roles of uptake1 and catechol-O-methyltransferase in removal of circulating catecholamines in the rabbit. Catecholamines 76-90 catechol O-methyltransferase Oryctolagus cuniculus 21-49 7527027-8 1994 A synthetic peptide corresponding to the GAP-43 domain that interacts with G0 inhibited catecholamine secretion. Catecholamines 88-101 growth associated protein 43 Homo sapiens 41-47 7711467-2 1994 ANP levels were compared with blood pressure, heart rate, plasma catecholamines and parameters of renal function. Catecholamines 65-79 natriuretic peptide A Homo sapiens 0-3 7986160-0 1994 Lipolysis in burned patients is stimulated by the beta 2-receptor for catecholamines. Catecholamines 70-84 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 50-56 7986160-12 1994 Thus, the increased lipolysis, characteristic of severely burned patients, is caused by stimulation of the beta 2-adrenergic receptors for catecholamines. Catecholamines 139-153 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 107-113 7898312-1 1994 Tyrosine hydroxylase (TH), the first and rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, is expressed within central and peripheral catecholaminergic cells. Catecholamines 85-98 tyrosine hydroxylase Mus musculus 0-20 7898312-1 1994 Tyrosine hydroxylase (TH), the first and rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, is expressed within central and peripheral catecholaminergic cells. Catecholamines 85-98 tyrosine hydroxylase Mus musculus 22-24 7988454-1 1994 We assessed the role of catecholamines in mediating the hypertriglyceridemia induced by lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF alpha) in rats by employing specific adrenoreceptor antagonists. Catecholamines 24-38 tumor necrosis factor Rattus norvegicus 116-143 7988454-1 1994 We assessed the role of catecholamines in mediating the hypertriglyceridemia induced by lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF alpha) in rats by employing specific adrenoreceptor antagonists. Catecholamines 24-38 tumor necrosis factor Rattus norvegicus 145-154 7989592-3 1994 Chromogranin A, an abundant protein complexed with catecholamines in secretory vesicles of chromaffin cells and sympathetic axons, is also augmented by glucocorticoids. Catecholamines 51-65 chromogranin A Rattus norvegicus 0-14 7898082-6 1994 Prazosin and propranolol, adrenergic blocking agents, and reserpine, a depletor of catecholamine stores, reduced either ET-1 or L-NAME pressor effects. Catecholamines 83-96 endothelin 1 Rattus norvegicus 120-124 7894468-6 1994 As the technical parameters and particularly the tissue fixation used to detect neutral endopeptidase are compatible with immunocytochemical detection of GnRH and tyrosine-hydroxylase (the rate limiting enzyme in the synthesis of catecholamines), two double immunolabelings were realised at the ultrastructural level to determine if GnRH and dopamine nerve endings have the enzyme inserted within their plasma membrane. Catecholamines 230-244 membrane metallo-endopeptidase Rattus norvegicus 80-101 7527848-1 1994 Substances found in the soluble extract of muscle can alter the differentiative fate of certain brain neurons in culture by triggering novel expression of the gene for the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) (Iacovitti et al., 1989; Iacovitt, 1991). Catecholamines 172-185 tyrosine hydroxylase Homo sapiens 206-226 7527848-1 1994 Substances found in the soluble extract of muscle can alter the differentiative fate of certain brain neurons in culture by triggering novel expression of the gene for the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) (Iacovitti et al., 1989; Iacovitt, 1991). Catecholamines 172-185 tyrosine hydroxylase Homo sapiens 228-230 7894468-6 1994 As the technical parameters and particularly the tissue fixation used to detect neutral endopeptidase are compatible with immunocytochemical detection of GnRH and tyrosine-hydroxylase (the rate limiting enzyme in the synthesis of catecholamines), two double immunolabelings were realised at the ultrastructural level to determine if GnRH and dopamine nerve endings have the enzyme inserted within their plasma membrane. Catecholamines 230-244 gonadotropin releasing hormone 1 Rattus norvegicus 154-158 7986204-5 1994 This relatively small increase in PNMT was reflected in the catecholamine levels in that the total epinephrine (EPI) was elevated by only 16% while norepinephrine (NE) was elevated by 99%, which caused a shift in the molar ratio of EPI to NE from 7.0 in the untreated control to 4.1 after forskolin treatment. Catecholamines 60-73 phenylethanolamine N-methyltransferase Bos taurus 34-38 7996204-2 1994 Recently we found that a specific inhibitor of myosin light chain kinase (MLCK), wortmannin, inhibits Ca(2+)-induced catecholamine release from digitonin-permeabilized chromaffin cells, suggesting an implication of MLCK in the mechanisms of Ca(2+)-induced exocytosis (Imaizumi et al., 1992b). Catecholamines 117-130 myosin light chain kinase Homo sapiens 47-72 7996204-2 1994 Recently we found that a specific inhibitor of myosin light chain kinase (MLCK), wortmannin, inhibits Ca(2+)-induced catecholamine release from digitonin-permeabilized chromaffin cells, suggesting an implication of MLCK in the mechanisms of Ca(2+)-induced exocytosis (Imaizumi et al., 1992b). Catecholamines 117-130 myosin light chain kinase Homo sapiens 74-78 7825812-2 1994 This phenomenon was due to activation of antigen nonspecific L3T4-/Lyt-2- T lymphocytes (double-negative T cells) by the beta-adrenergic action of endogenous catecholamines released from the adrenal gland after pain stimulation. Catecholamines 158-172 CD8 antigen, alpha chain Mus musculus 67-72 7825812-8 1994 These data suggest that the enhanced production of IL-2 in mice given pain stimulation resulted from the activation of L3T4- T cells by endogenous catecholamines released from the adrenal gland after pain stimulation. Catecholamines 147-161 interleukin 2 Mus musculus 51-55 7999068-4 1994 Sequencing of these STP-like sequences confirmed that STP is contained within contig 343.1 and maps proximal to FRA16E, and that a related sulphotransferase STM, encoding the catecholamine-sulphating enzyme, is contained within contig 55.4 and maps to the adjacent hybrid interval CY12-CY180A. Catecholamines 175-188 sulfotransferase family 1A member 1 Homo sapiens 20-23 7999068-4 1994 Sequencing of these STP-like sequences confirmed that STP is contained within contig 343.1 and maps proximal to FRA16E, and that a related sulphotransferase STM, encoding the catecholamine-sulphating enzyme, is contained within contig 55.4 and maps to the adjacent hybrid interval CY12-CY180A. Catecholamines 175-188 sulfotransferase family 1A member 1 Homo sapiens 54-57 7999068-4 1994 Sequencing of these STP-like sequences confirmed that STP is contained within contig 343.1 and maps proximal to FRA16E, and that a related sulphotransferase STM, encoding the catecholamine-sulphating enzyme, is contained within contig 55.4 and maps to the adjacent hybrid interval CY12-CY180A. Catecholamines 175-188 sulfotransferase family 1A member 3 Homo sapiens 157-160 7955144-4 1994 Vasoconstrictor responses to des-Arg9-bradykinin under low-tone conditions were attenuated by phentolamine, prazosin, and reserpine but not by sodium meclofenamate, suggesting that release of catecholamines and activation of alpha-adrenergic receptors are involved. Catecholamines 192-206 kininogen 1 Homo sapiens 38-48 7955144-6 1994 These results suggest that vasoconstrictor responses to des-Arg9-bradykinin under low-tone conditions are mediated by the activation of kinin B1 receptors, the release of catecholamines within the lung, and the activation of alpha-adrenergic receptors, whereas vasodilator responses under elevated tone conditions are mediated by activation of B1 receptors and the release of nitric oxide from the endothelium. Catecholamines 171-185 kininogen 1 Homo sapiens 65-75 7961964-1 1994 Dopamine beta-hydroxylase (DBH; EC 1.14.17.1) catalyzes the production of the neurotransmitter and hormone norepinephrine in the third step of the catecholamine biosynthesis pathway. Catecholamines 147-160 dopamine beta hydroxylase Mus musculus 0-25 7961964-1 1994 Dopamine beta-hydroxylase (DBH; EC 1.14.17.1) catalyzes the production of the neurotransmitter and hormone norepinephrine in the third step of the catecholamine biosynthesis pathway. Catecholamines 147-160 dopamine beta hydroxylase Mus musculus 27-30 7961964-5 1994 We detected a marked increase in DBH activity in various catecholamine-containing tissues of the mice that occurred as a consequence of expression of the catalytically active human DBH enzyme. Catecholamines 57-70 dopamine beta hydroxylase Mus musculus 33-36 7961964-5 1994 We detected a marked increase in DBH activity in various catecholamine-containing tissues of the mice that occurred as a consequence of expression of the catalytically active human DBH enzyme. Catecholamines 57-70 dopamine beta-hydroxylase Homo sapiens 181-184 7958625-4 1994 By contrast, the expression, specific activity, and immunoreactivity of other catecholamine-synthesizing enzymes, e.g., phenylethanolamine-N-methyl-transferase (PNMT), were not altered. Catecholamines 78-91 phenylethanolamine-N-methyltransferase Rattus norvegicus 161-165 7980462-1 1994 Cytochrome b561 is a major transmembrane protein of catecholamine and neuropeptide secretory vesicles. Catecholamines 52-65 cytochrome b561 Homo sapiens 0-15 7869619-4 1994 Catecholamine synthesis and tyrosine hydroxylase phosphorylation stimulated by the maximal effective concentration of dibutyryl cAMP or high K+, which activates Ca2+ uptake, were further enhanced by PACAP, suggesting that both cAMP- and Ca(2+)-dependent protein kinases may be involved in the stimulation of tyrosine hydroxylase phosphorylation and catecholamine synthesis caused by PACAP. Catecholamines 349-362 adenylate cyclase activating polypeptide 1 Bos taurus 199-204 7874370-0 1994 COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. Catecholamines 81-94 catechol-O-methyltransferase Homo sapiens 0-4 7965104-2 1994 Subsets of adrenal medullary cells and postganglionic sympathetic nerves coexpress the peptide neurotransmitter neuropeptide Y (NPY) with catecholamines. Catecholamines 138-152 neuropeptide Y Rattus norvegicus 112-126 7965104-2 1994 Subsets of adrenal medullary cells and postganglionic sympathetic nerves coexpress the peptide neurotransmitter neuropeptide Y (NPY) with catecholamines. Catecholamines 138-152 neuropeptide Y Rattus norvegicus 128-131 7967610-1 1994 Among catecholamine synthesizing enzymes, phenylethanolamine-N-methyltransferase (PNMT) exists only in adrenal and extra-adrenal pheochromocytoma has been believed not to produce adrenaline. Catecholamines 6-19 phenylethanolamine N-methyltransferase Homo sapiens 42-80 7967610-1 1994 Among catecholamine synthesizing enzymes, phenylethanolamine-N-methyltransferase (PNMT) exists only in adrenal and extra-adrenal pheochromocytoma has been believed not to produce adrenaline. Catecholamines 6-19 phenylethanolamine N-methyltransferase Homo sapiens 82-86 7869619-0 1994 Stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine synthesis in cultured bovine adrenal chromaffin cells: involvements of tyrosine hydroxylase phosphorylation caused by Ca2+ influx and cAMP. Catecholamines 76-89 adenylate cyclase activating polypeptide 1 Bos taurus 22-72 7869619-4 1994 Catecholamine synthesis and tyrosine hydroxylase phosphorylation stimulated by the maximal effective concentration of dibutyryl cAMP or high K+, which activates Ca2+ uptake, were further enhanced by PACAP, suggesting that both cAMP- and Ca(2+)-dependent protein kinases may be involved in the stimulation of tyrosine hydroxylase phosphorylation and catecholamine synthesis caused by PACAP. Catecholamines 0-13 adenylate cyclase activating polypeptide 1 Bos taurus 199-204 7869619-4 1994 Catecholamine synthesis and tyrosine hydroxylase phosphorylation stimulated by the maximal effective concentration of dibutyryl cAMP or high K+, which activates Ca2+ uptake, were further enhanced by PACAP, suggesting that both cAMP- and Ca(2+)-dependent protein kinases may be involved in the stimulation of tyrosine hydroxylase phosphorylation and catecholamine synthesis caused by PACAP. Catecholamines 0-13 adenylate cyclase activating polypeptide 1 Bos taurus 383-388 7862259-0 1994 Pertussis toxin pretreatment enhances catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide in cultured porcine adrenal medullary chromaffin cells: a possible role of the inositol lipid cascade. Catecholamines 38-51 adenylate cyclase activating polypeptide 1 Homo sapiens 73-123 7671121-0 1994 Immobilization stress may increase plasma interleukin-6 via central and peripheral catecholamines. Catecholamines 83-97 interleukin 6 Mus musculus 42-55 7862259-1 1994 We determined how pertussis toxin (PTX) pretreatment alters PACAP-induced catecholamine secretion in cultured porcine adrenal medullary cells. Catecholamines 74-87 adenylate cyclase activating polypeptide 1 Homo sapiens 60-65 7862259-2 1994 Pretreatment of these cells with PTX (1 ng/ml for 24 h or 10 ng/ml for 6 h) markedly enhanced PACAP-induced catecholamine secretion. Catecholamines 108-121 adenylate cyclase activating polypeptide 1 Homo sapiens 94-99 7862259-4 1994 We examined the role of the phosphoinositol cascade in potentiating the PACAP-induced catecholamine secretion by PTX and found that PACAP-induced accumulation of inositol phosphates in PTX-pretreated cells was significantly greater than that in untreated cells. Catecholamines 86-99 adenylate cyclase activating polypeptide 1 Homo sapiens 72-77 7862259-4 1994 We examined the role of the phosphoinositol cascade in potentiating the PACAP-induced catecholamine secretion by PTX and found that PACAP-induced accumulation of inositol phosphates in PTX-pretreated cells was significantly greater than that in untreated cells. Catecholamines 86-99 adenylate cyclase activating polypeptide 1 Homo sapiens 132-137 7862259-5 1994 Furthermore, removal of extracellular Ca2+ and addition of Ca2+ channel blockers inhibited the catecholamine secretion induced by PACAP in PTX-pretreated cells. Catecholamines 95-108 adenylate cyclase activating polypeptide 1 Homo sapiens 130-135 7969082-3 1994 Catecholamines and phenylethylamines, but not lower efficacy agonists, were more potent in inhibiting radioligand binding to the expressed alpha 1A/D subtype than to the alpha 1B or alpha 1C subtypes; this selectivity remained in the presence of different buffers, nucleotides, and cations. Catecholamines 0-14 calcium voltage-gated channel subunit alpha1 A Homo sapiens 139-147 7862259-6 1994 From these results, we speculate that a PTX-sensitive G-protein tonically inhibits phospholipase C. PTX enhances the PACAP-induced secretion of catecholamine by blocking the action of this inhibitory G-protein. Catecholamines 144-157 adenylate cyclase activating polypeptide 1 Homo sapiens 117-122 23961728-9 1994 Septal choline acetyltrans-ferase (CAT, the acetylcholine-synthesizing enzyme) activity was reduced and tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine biosynthesis) activity in noradrenergic lc neurons was increased after both the unilateral and bilateral lesion. Catecholamines 158-171 tyrosine hydroxylase Rattus norvegicus 104-124 7873097-8 1994 When compared with the development of catecholamine systems, it is clear that the NPY neurotransmitter system develops earlier. Catecholamines 38-51 neuropeptide Y S homeolog Xenopus laevis 82-85 7838011-5 1994 Conversely, promoting brain insulin activity with chromium picolinate may help to maintain the hypothalamus in a more functionally youthful state; increased hypothalamic catecholamine activity, sensitization of insulin-responsive central mechanisms regulating appetite and thermogenesis, and perhaps trophic effects on brain neurons may play a role in this regard. Catecholamines 170-183 insulin Homo sapiens 28-35 7529068-12 1994 Colocalization of GAL or VIP with tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, reveals a reduced immunoreactivity for TH in intensely GAL- or VIP-positive cells, and vice versa at day 6. Catecholamines 89-102 galanin and GMAP prepropeptide Rattus norvegicus 18-21 7529068-12 1994 Colocalization of GAL or VIP with tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, reveals a reduced immunoreactivity for TH in intensely GAL- or VIP-positive cells, and vice versa at day 6. Catecholamines 89-102 vasoactive intestinal peptide Rattus norvegicus 25-28 7719703-1 1994 Tyrosine hydroxylase (TH) is the key enzyme in the synthesis of catecholamines and may therefore be of aetiological relevance in the development of psychiatric illness. Catecholamines 64-78 tyrosine hydroxylase Homo sapiens 0-20 7529068-12 1994 Colocalization of GAL or VIP with tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, reveals a reduced immunoreactivity for TH in intensely GAL- or VIP-positive cells, and vice versa at day 6. Catecholamines 89-102 tyrosine hydroxylase Rattus norvegicus 34-54 7529068-12 1994 Colocalization of GAL or VIP with tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, reveals a reduced immunoreactivity for TH in intensely GAL- or VIP-positive cells, and vice versa at day 6. Catecholamines 89-102 tyrosine hydroxylase Rattus norvegicus 56-58 7529068-12 1994 Colocalization of GAL or VIP with tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, reveals a reduced immunoreactivity for TH in intensely GAL- or VIP-positive cells, and vice versa at day 6. Catecholamines 89-102 tyrosine hydroxylase Rattus norvegicus 153-155 7529068-12 1994 Colocalization of GAL or VIP with tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, reveals a reduced immunoreactivity for TH in intensely GAL- or VIP-positive cells, and vice versa at day 6. Catecholamines 89-102 galanin and GMAP prepropeptide Rattus norvegicus 169-172 7529068-12 1994 Colocalization of GAL or VIP with tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis, reveals a reduced immunoreactivity for TH in intensely GAL- or VIP-positive cells, and vice versa at day 6. Catecholamines 89-102 vasoactive intestinal peptide Rattus norvegicus 177-180 7719704-2 1994 DBH is required for conversion of dopamine to norepinephrine, the third step in catecholamine biosynthesis. Catecholamines 80-93 dopamine beta-hydroxylase Homo sapiens 0-3 7719703-1 1994 Tyrosine hydroxylase (TH) is the key enzyme in the synthesis of catecholamines and may therefore be of aetiological relevance in the development of psychiatric illness. Catecholamines 64-78 tyrosine hydroxylase Homo sapiens 22-24 7978886-6 1994 Within the sympathoadrenal system, interest focuses on a recently proposed (though as yet incompletely investigated) function of CgA: its ability to suppress catecholamine release from adrenal chromaffin cells when such cells are stimulated by their usual physiologic secretagogue. Catecholamines 158-171 chromogranin A Homo sapiens 129-132 7524340-3 1994 In contrast, SP inhibited the output of both catecholamines and enkephalins in response to acetylcholine, without affecting the output of corticotropin-releasing factor (CRF). Catecholamines 45-59 tachykinin precursor 1 Bos taurus 13-15 7804822-1 1994 In humans, the RNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines, can undergo alternative splicing to produce four different types of mRNA. Catecholamines 95-109 tyrosine hydroxylase Homo sapiens 23-43 7804822-1 1994 In humans, the RNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines, can undergo alternative splicing to produce four different types of mRNA. Catecholamines 95-109 tyrosine hydroxylase Homo sapiens 45-47 7827340-0 1994 Generalized presence of a PEC-60-like peptide in catecholamine neurones. Catecholamines 49-62 serine peptidase inhibitor Kazal type 4 Homo sapiens 26-32 7827340-4 1994 PEC-60-like immunoreactivity was present in cell bodies, dendrites and nerve terminals of virtually all catecholamine neurones examined and including the noradrenergic gland cells of the adrenal medulla. Catecholamines 104-117 serine peptidase inhibitor Kazal type 4 Homo sapiens 0-6 7982299-7 1994 Circumstantial evidence, including a close homology within the aryl sulfatases and steroid sulfatase gene, the first implicated in catecholamine metabolism, the second in steroid metabolism, suggests a genetic defect of sulfatases in essential hypertension. Catecholamines 131-144 arylsulfatase family member H Homo sapiens 68-77 7936367-2 1994 The mineral, which enters in the composition of zinc-enzyme "angiotensin-converting-enzyme" (ACE), takes part in arterial pressure regulation also through influences on others hormonal systems, which carry on many complex actions on circulation (glucocorticoids, catecholamines). Catecholamines 263-277 angiotensin I converting enzyme Homo sapiens 93-96 7812764-10 1994 The selective inhibition of TPH by dopamine-derived catechol isoquinolines was discussed in relationship to the interactions between catecholamines, indoleamines and their metabolites in the brain under physiological and pathological conditions. Catecholamines 133-147 tryptophan hydroxylase 1 Rattus norvegicus 28-31 7914698-4 1994 Our data demonstrate that tyrosine hydroxylase and catecholamines declined and choline acetyltransferase increased in response to LIF. Catecholamines 51-65 leukemia inhibitory factor Mus musculus 130-133 7894976-7 1994 Thus, 4 may provide a reliable measure of TH activity in such catecholamine structures. Catecholamines 62-75 tyrosine hydroxylase Rattus norvegicus 42-44 7982299-8 1994 A similar, but secondary, sulfatase defect may affect catecholamine metabolism and action in chronic renal failure. Catecholamines 54-67 arylsulfatase family member H Homo sapiens 26-35 7982460-5 1994 The present study suggests that prostaglandin E2 inhibits the release of catecholamines in pithed rats via prostanoid receptors of the EP3 subtype, probably located presynaptically on the postganglionic sympathetic nerve fibres. Catecholamines 73-87 prostaglandin E receptor 3 Rattus norvegicus 135-138 7822236-6 1994 RNA blot analysis revealed that Rabphilin-3A mRNA is expressed in endocrine and hormone-secreting clonal cells, including rat adrenal glands, MIN6, the hamster insulin-secreting cell line, HIT-T15, and the rat catecholamine-secreting cell line, PC12, as well as rat brain. Catecholamines 210-223 rabphilin 3A Rattus norvegicus 32-44 8035193-1 1994 Aromatic L-amino acid decarboxylase (AAAD) is required for the synthesis of catecholamines, serotonin, and the trace amines. Catecholamines 76-90 dopa decarboxylase Mus musculus 0-35 8035193-1 1994 Aromatic L-amino acid decarboxylase (AAAD) is required for the synthesis of catecholamines, serotonin, and the trace amines. Catecholamines 76-90 dopa decarboxylase Mus musculus 37-41 8035878-6 1994 This effect of endothelin-1 should help protect the ventricle against potentially arrhythmogenic shortening of the action potential during ischaemia when the circulating levels of catecholamines are increased. Catecholamines 180-194 endothelin-1 Cavia porcellus 15-27 8026585-2 1994 Nicotinic (but not muscarinic) receptors mediated the Ca(2+)-dependent co-secretion of adrenomedullin and catecholamines, with the molar ratio of adrenomedullin/catecholamines secreted into the medium being equal to the ratio stored in the cells. Catecholamines 106-120 adrenomedullin Bos taurus 146-160 8026585-2 1994 Nicotinic (but not muscarinic) receptors mediated the Ca(2+)-dependent co-secretion of adrenomedullin and catecholamines, with the molar ratio of adrenomedullin/catecholamines secreted into the medium being equal to the ratio stored in the cells. Catecholamines 161-175 adrenomedullin Bos taurus 87-101 8048512-8 1994 The results indicate that 1) the enhanced whole body glucose metabolism seen after central administration of IL-1 alpha is mediated by increased sympathoadrenal activity and 2) the IL-1 alpha-induced increase in pancreatic insulin and glucagon secretion as well as part of the peripheral catecholamine release is mediated by central adrenoreceptors. Catecholamines 288-301 interleukin 1 alpha Rattus norvegicus 109-119 8048512-8 1994 The results indicate that 1) the enhanced whole body glucose metabolism seen after central administration of IL-1 alpha is mediated by increased sympathoadrenal activity and 2) the IL-1 alpha-induced increase in pancreatic insulin and glucagon secretion as well as part of the peripheral catecholamine release is mediated by central adrenoreceptors. Catecholamines 288-301 interleukin 1 alpha Rattus norvegicus 181-191 7964280-0 1994 Angiotensin II-mediated catecholamine release during the pressor response in rats. Catecholamines 24-37 angiotensinogen Rattus norvegicus 0-14 7964280-1 1994 Angiotensin II (ANG II)-mediated catecholamine release and its possible contribution to the pressor response was assessed in baroreceptor-denervated rats. Catecholamines 33-46 angiotensinogen Rattus norvegicus 0-14 7964280-1 1994 Angiotensin II (ANG II)-mediated catecholamine release and its possible contribution to the pressor response was assessed in baroreceptor-denervated rats. Catecholamines 33-46 angiotensinogen Rattus norvegicus 16-22 8035323-1 1994 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 0-28 8035323-1 1994 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. Catecholamines 67-80 catechol-O-methyltransferase Homo sapiens 30-34 7614422-3 1994 The aim of the present study was to investigate ET-1 plasma concentration in patients with mild-to-moderate essential hypertension and its interrelationship with catecholamines, neuropeptide Y and atrial natriuretic peptide (ANP). Catecholamines 162-176 endothelin 1 Homo sapiens 48-52 7812042-1 1994 Secretion of parathyroid hormone (PTH) is regulated in part by a classical "stimulus-secretion" pathway responsive to catecholamines. Catecholamines 118-132 parathyroid hormone Bos taurus 13-32 7812042-1 1994 Secretion of parathyroid hormone (PTH) is regulated in part by a classical "stimulus-secretion" pathway responsive to catecholamines. Catecholamines 118-132 parathyroid hormone Bos taurus 34-37 18407209-4 1994 The expression o f several other receptors by GnRH neurons provides the means for integrated regulation of pulse generator activity from without the network by agonists including glutamate, GABA, endothelin, and catecholamines. Catecholamines 212-226 gonadotropin releasing hormone 1 Homo sapiens 46-50 7912437-2 1994 Here we examine the changes of gene expression of tyrosine hydroxylase (TH; EC 1.14.16.2), the initial enzyme of catecholamine biosynthesis, with stress. Catecholamines 113-126 tyrosine hydroxylase Rattus norvegicus 50-70 7912437-2 1994 Here we examine the changes of gene expression of tyrosine hydroxylase (TH; EC 1.14.16.2), the initial enzyme of catecholamine biosynthesis, with stress. Catecholamines 113-126 tyrosine hydroxylase Rattus norvegicus 72-74 7929473-2 1994 In postganglionic sympathetic neurones and adrenal chromaffin cells, catecholamines are co-stored in vesicles with soluble peptides, including chromogranin A (CgA) and neuropeptide Y (NPY), which are subject to exocytotic co-release with catecholamines. Catecholamines 69-83 neuropeptide Y Homo sapiens 168-182 7929473-2 1994 In postganglionic sympathetic neurones and adrenal chromaffin cells, catecholamines are co-stored in vesicles with soluble peptides, including chromogranin A (CgA) and neuropeptide Y (NPY), which are subject to exocytotic co-release with catecholamines. Catecholamines 69-83 neuropeptide Y Homo sapiens 184-187 7929473-24 1994 Activation of catecholamine release from either the adrenal medulla or sympathetic nerves, therefore, results in quite different changes in plasma concentrations of the catecholamine storage vesicle peptides CgA and NPY. Catecholamines 14-27 chromogranin A Homo sapiens 208-211 7929473-24 1994 Activation of catecholamine release from either the adrenal medulla or sympathetic nerves, therefore, results in quite different changes in plasma concentrations of the catecholamine storage vesicle peptides CgA and NPY. Catecholamines 14-27 neuropeptide Y Homo sapiens 216-219 7929473-24 1994 Activation of catecholamine release from either the adrenal medulla or sympathetic nerves, therefore, results in quite different changes in plasma concentrations of the catecholamine storage vesicle peptides CgA and NPY. Catecholamines 169-182 chromogranin A Homo sapiens 208-211 7929473-24 1994 Activation of catecholamine release from either the adrenal medulla or sympathetic nerves, therefore, results in quite different changes in plasma concentrations of the catecholamine storage vesicle peptides CgA and NPY. Catecholamines 169-182 neuropeptide Y Homo sapiens 216-219 7801765-3 1994 Catecholamines, serotonin, and cocaine inhibited the DA transport, but tyramine (TA) and tryptamine, as well as benztropine and imipramine (which are potent inhibitors for hepatic TA transporter and neuronal DA transporter), had no inhibitory effect on the transport of DA in these cells. Catecholamines 0-14 solute carrier family 6 member 3 Rattus norvegicus 208-222 8065532-1 1994 Wild type PC12 pheochromocytoma cells express a Na(+)-dependent norepinephrine transporter that operates in the uptake of catecholamines. Catecholamines 122-136 solute carrier family 6 member 2 Rattus norvegicus 64-90 8069676-0 1994 Cd2+ and Co2+ at micromolar concentrations stimulate catecholamine secretion by increasing the cytosolic free Ca2+ concentration in cat adrenal chromaffin cells. Catecholamines 53-66 CD2 molecule Homo sapiens 0-3 8185573-4 1994 In addition, induction of neuronal differentiation in PC12 cells, which causes an increase in catecholamine secretion, also led to an increase in rab3C expression. Catecholamines 94-107 RAB3C, member RAS oncogene family Rattus norvegicus 146-151 7910484-1 1994 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in catecholamine biosynthesis. Catecholamines 62-75 tyrosine hydroxylase Rattus norvegicus 0-20 7910484-1 1994 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in catecholamine biosynthesis. Catecholamines 62-75 tyrosine hydroxylase Rattus norvegicus 22-24 8062098-2 1994 It is then presumed that the action of NMDA on GnRH neurons may be indirectly mediated through interneurons, such as catecholamines. Catecholamines 117-131 gonadotropin releasing hormone 1 Rattus norvegicus 47-51 7914819-7 1994 Both the neurochemical data and the developmental response to the general catecholamine agonist, amphetamine, suggest that the monaminergic neurotransmitter system may be altered as a consequence of the hotfoot mutation. Catecholamines 74-87 glutamate receptor, ionotropic, delta 2 Mus musculus 203-210 8198537-12 1994 7,7-Dimethyl-5,8-eicosadienoic acid, a potent inhibitor of intracellular phospholipase A2, inhibited both the arachidonate release and the MgATP-independent catecholamine secretion evoked by mastoparan. Catecholamines 157-170 phospholipase A2 group IB Homo sapiens 73-89 8193992-1 1994 OBJECTIVE: To clarify whether central catecholamine systems are modulated by neuropeptide Y (NPY) soon after imposing an increased pressure overload on the heart. Catecholamines 38-51 neuropeptide Y Rattus norvegicus 77-91 7912958-4 1994 The increase in catecholamine metabolite levels could be due to stimulation of tyrosine hydroxylase (TH) activity in the catecholaminergic systems of this region. Catecholamines 16-29 tyrosine hydroxylase Homo sapiens 79-99 7912958-4 1994 The increase in catecholamine metabolite levels could be due to stimulation of tyrosine hydroxylase (TH) activity in the catecholaminergic systems of this region. Catecholamines 16-29 tyrosine hydroxylase Homo sapiens 101-103 8181167-5 1994 Neutrophils may cause lysis of myocytes, and cytokines produced by infiltrating macrophages and HtL may reach a sufficient concentration in the interstitial microenvironment to decrease myocyte catecholamine responsiveness and/or directly depress myocyte contractility. Catecholamines 194-207 Leucine transport, high Homo sapiens 96-99 8025914-0 1994 Angiotensin II associated cardiac myocyte necrosis: role of adrenal catecholamines. Catecholamines 68-82 angiotensinogen Rattus norvegicus 0-14 8025914-4 1994 The aim of this study was to determine whether myocyte necrosis is induced directly by angiotensin II, or indirectly by catecholamines or aldosterone released from adrenal glands in response to angiotensin II. Catecholamines 120-134 angiotensinogen Rattus norvegicus 194-208 8025914-9 1994 CONCLUSIONS: In the presence of increased circulating levels of angiotensin II, bilateral medullectomy and total adrenalectomy (in contrast to spironolactone) reduced myocyte injury and scarring of the right and left ventricular myocardium, suggesting that the cytotoxic effect of angiotensin II is largely indirect and related to circulating catecholamines released by the adrenal medulla. Catecholamines 343-357 angiotensinogen Rattus norvegicus 64-78 8158121-1 1994 Previous studies have demonstrated that bovine chromaffin cells cultured in medium with 10 nM insulin-like growth factor-I (IGF-I) secrete about twofold more catecholamine when exposed to secretory stimuli than do cells cultured without IGF-I. Catecholamines 158-171 insulin like growth factor 1 Bos taurus 94-122 7908942-1 1994 In order to define cell type-specific elements associated with the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), transient transfections of promoter deletion constructs were used to test relative reporter-gene activities in TH-expressing and -nonexpressing cell lines. Catecholamines 67-80 tyrosine hydroxylase Rattus norvegicus 102-122 7908942-1 1994 In order to define cell type-specific elements associated with the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), transient transfections of promoter deletion constructs were used to test relative reporter-gene activities in TH-expressing and -nonexpressing cell lines. Catecholamines 67-80 tyrosine hydroxylase Rattus norvegicus 124-126 8158121-1 1994 Previous studies have demonstrated that bovine chromaffin cells cultured in medium with 10 nM insulin-like growth factor-I (IGF-I) secrete about twofold more catecholamine when exposed to secretory stimuli than do cells cultured without IGF-I. Catecholamines 158-171 insulin like growth factor 1 Bos taurus 124-129 8063046-0 1994 Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta 2-adrenoceptors. Catecholamines 0-13 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 102-108 7480961-3 1994 Previous studies indicated that plasma ANF provides prognostic information and, ANF levels closely related to both severity of disease and catecholamine levels but, it is still unclear if high circulating levels of ANF, which are present in heart failure constantly, may be to correlate with sympathetic nervous activity in man. Catecholamines 139-152 natriuretic peptide A Homo sapiens 80-83 7480961-3 1994 Previous studies indicated that plasma ANF provides prognostic information and, ANF levels closely related to both severity of disease and catecholamine levels but, it is still unclear if high circulating levels of ANF, which are present in heart failure constantly, may be to correlate with sympathetic nervous activity in man. Catecholamines 139-152 natriuretic peptide A Homo sapiens 80-83 8184985-3 1994 ET-1 (icv) caused significant increases in mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), plasma catecholamines, and vasopressin levels. Catecholamines 121-135 endothelin-1 Oryctolagus cuniculus 0-4 8166703-0 1994 Lipoxygenase-catalyzed oxidation of catecholamines. Catecholamines 36-50 linoleate 9S-lipoxygenase-4 Glycine max 0-12 8166703-1 1994 Dopa and structurally related catecholamines in presence of hydrogen peroxide are oxidized in vitro by soybean lipoxygenase producing the corresponding melanin pigments. Catecholamines 30-44 linoleate 9S-lipoxygenase-4 Glycine max 111-123 7913046-10 1994 administration of PAF in rats is dependent on the stimulation of beta-adrenoceptors by catecholamines released from adrenal glands. Catecholamines 87-101 PCNA clamp associated factor Rattus norvegicus 18-21 8063046-10 1994 Thus, lipolytic catecholamine resistance is present in abdominal obesity, due to low density of beta 2-adrenoceptors, which in its turn may be caused by a post-transcriptional defect in beta 2-receptor expression. Catecholamines 16-29 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 96-102 8063046-10 1994 Thus, lipolytic catecholamine resistance is present in abdominal obesity, due to low density of beta 2-adrenoceptors, which in its turn may be caused by a post-transcriptional defect in beta 2-receptor expression. Catecholamines 16-29 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 186-192 7916000-5 1994 Since human mononuclear leukocytes possess beta 2-, but not beta 1-adrenoceptors (Brodde, Engel and Hoyer 1981), catecholamines may act via beta-adrenergic receptors of the beta 2-subtype. Catecholamines 113-127 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 173-179 7916000-9 1994 The results provide evidence that catecholamines may inhibit the synthesis rate of fatty acids by stimulation of both, beta 2- and alpha 2-adrenergic receptors. Catecholamines 34-48 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 119-125 7916000-5 1994 Since human mononuclear leukocytes possess beta 2-, but not beta 1-adrenoceptors (Brodde, Engel and Hoyer 1981), catecholamines may act via beta-adrenergic receptors of the beta 2-subtype. Catecholamines 113-127 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 43-49 7914681-6 1994 Simultaneous staining for both Fos and tyrosine hydroxylase revealed Fos immunoreactivity in catecholamine neurons, including A1, A2, C1, A5, subcoeruleus and locus coeruleus (A6) groups. Catecholamines 93-106 proto-oncogene c-Fos Oryctolagus cuniculus 31-34 7916342-1 1994 We performed a comparative study on tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, in two ocular tissues, the retina and the iris-ciliary body. Catecholamines 89-102 tyrosine hydroxylase Bos taurus 36-56 7916342-1 1994 We performed a comparative study on tyrosine hydroxylase (TH), a rate-limiting enzyme in catecholamine biosynthesis, in two ocular tissues, the retina and the iris-ciliary body. Catecholamines 89-102 tyrosine hydroxylase Bos taurus 58-60 7523477-0 1994 Tyrosine hydroxylase indicates cell differentiation of catecholamine biosynthesis in neuroendocrine tumors. Catecholamines 55-68 tyrosine hydroxylase Homo sapiens 0-20 7908289-1 1994 Reduced oxygen tension (hypoxia) induces a 3-fold increase in stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line. Catecholamines 139-152 tyrosine hydroxylase Rattus norvegicus 84-104 7908289-1 1994 Reduced oxygen tension (hypoxia) induces a 3-fold increase in stability of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, in the pheochromocytoma (PC12) clonal cell line. Catecholamines 139-152 tyrosine hydroxylase Rattus norvegicus 106-108 7523477-1 1994 The intracellular localization of tyrosine hydroxylase (TH), which is the rate limiting enzyme in catecholamine (CA) biosynthesis, and its activity in various adrenal and other neuroendocrine tumors was studied. Catecholamines 98-111 tyrosine hydroxylase Homo sapiens 34-54 7523477-1 1994 The intracellular localization of tyrosine hydroxylase (TH), which is the rate limiting enzyme in catecholamine (CA) biosynthesis, and its activity in various adrenal and other neuroendocrine tumors was studied. Catecholamines 98-111 tyrosine hydroxylase Homo sapiens 56-58 8049696-4 1994 All these mechanisms are involved in homologous and heterologous regulation of beta 2-AR, which accounts for the modulation of beta 2-AR synthesis and responsiveness mediated by catecholamines, steroid hormones, inflammatory mediators and other agents. Catecholamines 178-192 adrenoceptor beta 2 Homo sapiens 79-88 7914681-6 1994 Simultaneous staining for both Fos and tyrosine hydroxylase revealed Fos immunoreactivity in catecholamine neurons, including A1, A2, C1, A5, subcoeruleus and locus coeruleus (A6) groups. Catecholamines 93-106 proto-oncogene c-Fos Oryctolagus cuniculus 69-72 8049696-4 1994 All these mechanisms are involved in homologous and heterologous regulation of beta 2-AR, which accounts for the modulation of beta 2-AR synthesis and responsiveness mediated by catecholamines, steroid hormones, inflammatory mediators and other agents. Catecholamines 178-192 adrenoceptor beta 2 Homo sapiens 127-136 8058111-16 1994 CGRP are mediated by catecholamine release due to stimulation of sympathetic nervous system activity, possibly via specific CGRP receptors in the central nervous system. Catecholamines 21-34 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 7909223-6 1994 Thus, MDMA is converted to the catecholamine DHMA by CYP2D6, and this may give rise to genetically-determined differences in toxicity. Catecholamines 31-44 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 53-59 8058111-16 1994 CGRP are mediated by catecholamine release due to stimulation of sympathetic nervous system activity, possibly via specific CGRP receptors in the central nervous system. Catecholamines 21-34 calcitonin-related polypeptide alpha Rattus norvegicus 124-128 8006835-11 1994 Perfusion with VIP (10 microM for 4 min) resulted in the secretion of 27 ng of catecholamines and the ratio of adrenaline to noradrenaline was 9.7. Catecholamines 79-93 vasoactive intestinal peptide Rattus norvegicus 15-18 8127373-1 1994 Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 0-28 8127373-1 1994 Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. Catecholamines 114-127 catechol-O-methyltransferase Homo sapiens 30-34 8006835-12 1994 A higher concentration of VIP (20 microM for 4 min) resulted in the secretion of greater amounts of catecholamines (102 ng) without significantly altering the ratio of adrenaline to noradrenaline (10.9). Catecholamines 100-114 vasoactive intestinal peptide Rattus norvegicus 26-29 8006835-14 1994 Perfusion with as low as 0.01 microM pituitary adenylate cyclase-activating polypeptide (PACAP) increased the secretion of catecholamines to 31 ng and the secretion increased in a dose-dependent manner up to 0.3 microM. Catecholamines 123-137 adenylate cyclase activating polypeptide 1 Rattus norvegicus 37-87 8006835-14 1994 Perfusion with as low as 0.01 microM pituitary adenylate cyclase-activating polypeptide (PACAP) increased the secretion of catecholamines to 31 ng and the secretion increased in a dose-dependent manner up to 0.3 microM. Catecholamines 123-137 adenylate cyclase activating polypeptide 1 Rattus norvegicus 89-94 8156281-0 1994 Role of central catecholamines in the modulation of corticotrophin-releasing factor mRNA during adjuvant-induced arthritis in the rat. Catecholamines 16-30 corticotropin releasing hormone Rattus norvegicus 52-83 7912405-7 1994 Veratridine treatment also increased the levels of mRNAs for the catecholamine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT), and proenkephalin A (PEK). Catecholamines 65-78 phenylethanolamine N-methyltransferase Bos taurus 99-137 7912405-7 1994 Veratridine treatment also increased the levels of mRNAs for the catecholamine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT), and proenkephalin A (PEK). Catecholamines 65-78 phenylethanolamine N-methyltransferase Bos taurus 139-143 7509734-0 1994 Catecholamines stimulate the synthesis and release of insulin-like growth factor binding protein-1 (IGFBP-1) by fetal sheep liver in vivo. Catecholamines 0-14 insulin-like growth factor-binding protein 1 Ovis aries 54-98 7509734-0 1994 Catecholamines stimulate the synthesis and release of insulin-like growth factor binding protein-1 (IGFBP-1) by fetal sheep liver in vivo. Catecholamines 0-14 insulin-like growth factor-binding protein 1 Ovis aries 100-107 7509734-2 1994 Since IGFBP-1 synthesis in liver cells in vitro is stimulated by compounds that increase intracellular cAMP concentrations, we hypothesized that the increased IGFBP-1 synthesis during prolonged hypoxemia may be induced by circulating catecholamines, that are released during hypoxia, and that elevate fetal liver cAMP levels. Catecholamines 234-248 insulin-like growth factor-binding protein 1 Ovis aries 6-13 7509734-2 1994 Since IGFBP-1 synthesis in liver cells in vitro is stimulated by compounds that increase intracellular cAMP concentrations, we hypothesized that the increased IGFBP-1 synthesis during prolonged hypoxemia may be induced by circulating catecholamines, that are released during hypoxia, and that elevate fetal liver cAMP levels. Catecholamines 234-248 insulin-like growth factor-binding protein 1 Ovis aries 159-166 7509734-3 1994 Our aim was to determine the effect of 24-h catecholamine infusions on the synthesis and release of IGFBP-1 and IGFBP-2 in fetal sheep. Catecholamines 44-57 insulin-like growth factor-binding protein 1 Ovis aries 100-107 7509734-3 1994 Our aim was to determine the effect of 24-h catecholamine infusions on the synthesis and release of IGFBP-1 and IGFBP-2 in fetal sheep. Catecholamines 44-57 insulin-like growth factor-binding protein 2 Ovis aries 112-119 7509377-5 1994 The level of enhanced catecholamine release correlated directly with the time and level of exogenous c-src expression. Catecholamines 22-35 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 101-106 8156092-5 1994 In which catecholamine levels from the cord blood were low despite simultaneous elevated maternal values (1.93 and 29.46 nmol/l norepinephrine, respectively), possibly owing to the high activity of the catecholamine degradative enzymes monoamine oxidase and COMT at the placental level. Catecholamines 202-215 catechol-O-methyltransferase Homo sapiens 258-262 8156093-0 1994 Plasma catecholamines after thyrotropin-releasing hormone administration in hypothyroid patients before and during therapy. Catecholamines 7-21 thyrotropin releasing hormone Homo sapiens 28-57 7509377-7 1994 Surprisingly, exogenous expression of an enzymatically inactive mutant c-src also restored catecholamine release, indicating that regions of the introduced c-src protein other than the kinase domain may affect catecholamine release. Catecholamines 91-104 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 71-76 7509377-7 1994 Surprisingly, exogenous expression of an enzymatically inactive mutant c-src also restored catecholamine release, indicating that regions of the introduced c-src protein other than the kinase domain may affect catecholamine release. Catecholamines 91-104 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 156-161 7509377-7 1994 Surprisingly, exogenous expression of an enzymatically inactive mutant c-src also restored catecholamine release, indicating that regions of the introduced c-src protein other than the kinase domain may affect catecholamine release. Catecholamines 210-223 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 71-76 7509377-7 1994 Surprisingly, exogenous expression of an enzymatically inactive mutant c-src also restored catecholamine release, indicating that regions of the introduced c-src protein other than the kinase domain may affect catecholamine release. Catecholamines 210-223 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 156-161 7910672-6 1994 A most intriguing property of rat chromaffin cells is that stimulation of nicotinic, muscarinic, VIP or PACAP receptors are each able to produce robust catecholamine secretion on their own. Catecholamines 152-165 vasoactive intestinal peptide Rattus norvegicus 97-100 7908406-4 1994 The increase and its reversal both were independent of the possible presence of contaminating catecholamines in the culture medium and thus appear to reflect spontaneous beta 2AR activity and direct antagonist-receptor interactions, respectively. Catecholamines 94-108 adrenoceptor beta 2 Homo sapiens 170-178 7910672-6 1994 A most intriguing property of rat chromaffin cells is that stimulation of nicotinic, muscarinic, VIP or PACAP receptors are each able to produce robust catecholamine secretion on their own. Catecholamines 152-165 adenylate cyclase activating polypeptide 1 Rattus norvegicus 104-109 7910672-9 1994 We demonstrate that acetylcholine, nicotine, muscarine, VIP and PACAP are each able to evoke catecholamine secretion from a single chromaffin cell. Catecholamines 93-106 vasoactive intestinal peptide Rattus norvegicus 56-59 7910672-9 1994 We demonstrate that acetylcholine, nicotine, muscarine, VIP and PACAP are each able to evoke catecholamine secretion from a single chromaffin cell. Catecholamines 93-106 adenylate cyclase activating polypeptide 1 Rattus norvegicus 64-69 7515319-3 1994 Brainstem sections were then processed immunohistochemically for the identification of cell bodies containing the catecholamine biosynthetic enzymes tyrosine hydroxylase, dopamine beta-hydroxylase (DBH) or phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 114-127 dopamine beta-hydroxylase Rattus norvegicus 171-196 8029532-1 1994 Cardiac arrest is associated with major metabolic disturbances, including severe hypoxia and large increases in circulating catecholamines, both of which are known to stimulate generation of the potent endothelium-derived vasoconstrictor peptide endothelin-1. Catecholamines 124-138 endothelin 1 Homo sapiens 246-258 7908852-0 1994 Vasoconstriction induced by inhalation of irritant vapour is associated with appearance of Fos protein in C1 catecholamine neurons in rabbit medulla oblongata. Catecholamines 109-122 proto-oncogene c-Fos Oryctolagus cuniculus 91-94 7909932-2 1994 An antisense oligonucleotide corresponding to the start coding region of rat tyrosine hydroxylase (TH) mRNA, the transcriptional message of the rate limiting enzyme in the metabolic pathway leading to catecholamine synthesis, was constructed and injected into the ventral tegmental area (VTA). Catecholamines 201-214 tyrosine hydroxylase Rattus norvegicus 77-97 7909932-2 1994 An antisense oligonucleotide corresponding to the start coding region of rat tyrosine hydroxylase (TH) mRNA, the transcriptional message of the rate limiting enzyme in the metabolic pathway leading to catecholamine synthesis, was constructed and injected into the ventral tegmental area (VTA). Catecholamines 201-214 tyrosine hydroxylase Rattus norvegicus 99-101 8177860-6 1994 CGRP is a powerful endogenous vasodilator in man; plasma concentrations of 56 pmol/l (slightly above physiological levels) provoke flush, hypotension and secondary catecholamine release and subsequent tachycardia. Catecholamines 164-177 calcitonin related polypeptide alpha Homo sapiens 0-4 8141398-5 1994 The increases in glucose and catecholamines induced by 2-B4O injection were abolished by bilateral splanchnicotomy (SPX) but not by pretreatment with anti-corticotropin-releasing factor (CRF) antibody. Catecholamines 29-43 spexin hormone Rattus norvegicus 116-119 8143425-2 1994 Dopamine beta-hydroxylase is stored and released with catecholamines by exocytosis from secretory vesicles in noradrenergic neurons and chromaffin cells. Catecholamines 54-68 dopamine beta-hydroxylase Homo sapiens 0-25 8141314-9 1994 These results suggest that TGF-beta 1 in the lung could play a role in changing the responsiveness of airway smooth muscle cells to endogenous catecholamines and to beta-adrenergic agonists used in therapy. Catecholamines 143-157 transforming growth factor beta 1 Homo sapiens 27-37 8299567-8 1994 Dexamethasone-differentiated PC12 cells were, however, responsive to LP-NPY, as this agonist enhanced evoked catecholamine overflow and inhibited binding of [125I]NPY-(1-36). Catecholamines 109-122 neuropeptide Y Rattus norvegicus 72-75 8106563-10 1994 These findings suggest that down-regulation of gas-6 expression during hepatic regeneration is triggered by catecholamines interaction with alpha-1-adrenergic receptors and by subsequent calcium release. Catecholamines 108-122 growth arrest specific 6 Rattus norvegicus 47-52 8106563-12 1994 Therefore, we suggest that up-regulation of gas-6 gene expression is mediated by the interaction of calcium with calmodulin, independently of catecholamines. Catecholamines 142-156 growth arrest specific 6 Rattus norvegicus 44-49 8299567-9 1994 Peptide-YY also enhanced catecholamine overflow, but only significantly at 100 nM. Catecholamines 25-38 peptide YY Rattus norvegicus 0-10 8299567-4 1994 NPY 13-36 1) inhibited binding of [125I]NPY 1-36, 2) inhibited accumulation of evoked cAMP, and 3) inhibited evoked catecholamine overflow. Catecholamines 116-129 neuropeptide Y Rattus norvegicus 0-3 8299567-10 1994 The data suggest differential expression of NPY receptor subtypes on neuronal and endocrine cells where catecholamine overflow is a key feature. Catecholamines 104-117 neuropeptide Y Rattus norvegicus 44-47 8299567-11 1994 These studies further demonstrate inhibitory or excitatory modulation of catecholamine transmission by NPY via distinct receptor subtypes in homogeneous sympathoadrenomedullary models resembling sympathetic neurons and chromaffin cells. Catecholamines 73-86 neuropeptide Y Rattus norvegicus 103-106 7906732-0 1994 C-type natriuretic peptide stimulates catecholamine synthesis through the accumulation of cyclic GMP in cultured bovine adrenal medullary cells. Catecholamines 38-51 natriuretic peptide C Bos taurus 0-26 7906732-6 1994 5) CNP stimulated the synthesis of 14C-labeled catecholamines from [14C] tyrosine but not from [14C] dopa. Catecholamines 47-61 natriuretic peptide C Bos taurus 3-6 8307017-2 1994 6-Pyruvoyl-tetrahydropterin synthase is the rate-limiting enzyme in the synthesis of human tetrahydrobiopterin, a cofactor for several hydroxylases involved in catecholamine and serotonin biosynthesis. Catecholamines 160-173 6-pyruvoyltetrahydropterin synthase Homo sapiens 0-36 8190350-0 1994 Neuropeptide Y (NPY)- and vasoactive intestinal peptide (VIP)-induced aldosterone secretion by rat capsule/glomerular zone could be mediated by catecholamines via beta 1 adrenergic receptors. Catecholamines 144-158 neuropeptide Y Rattus norvegicus 0-14 8190350-0 1994 Neuropeptide Y (NPY)- and vasoactive intestinal peptide (VIP)-induced aldosterone secretion by rat capsule/glomerular zone could be mediated by catecholamines via beta 1 adrenergic receptors. Catecholamines 144-158 neuropeptide Y Rattus norvegicus 16-19 8190350-0 1994 Neuropeptide Y (NPY)- and vasoactive intestinal peptide (VIP)-induced aldosterone secretion by rat capsule/glomerular zone could be mediated by catecholamines via beta 1 adrenergic receptors. Catecholamines 144-158 vasoactive intestinal peptide Rattus norvegicus 57-60 8190350-3 1994 The two NPY analogs as well as the VIP stimulated the release of catecholamines and of aldosterone. Catecholamines 65-79 neuropeptide Y Rattus norvegicus 8-11 8190350-3 1994 The two NPY analogs as well as the VIP stimulated the release of catecholamines and of aldosterone. Catecholamines 65-79 vasoactive intestinal peptide Rattus norvegicus 35-38 8190253-0 1994 c-fos expression in hypothalamic neurosecretory and brainstem catecholamine cells following noxious somatic stimuli. Catecholamines 62-75 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 0-5 8190253-1 1994 Noxious somatic stimuli elicit vasopressin secretion, an effect thought to result from activation of a facilitatory input from A1 catecholamine cells of the medulla oblongata. Catecholamines 130-143 arginine vasopressin Homo sapiens 31-42 8190253-2 1994 To better characterize the A1 cell response and effects on other neuroendocrine A1 projection targets, particularly within the paraventricular nucleus, we have now mapped c-fos expression in neurochemically identified catecholamine and neurosecretory cells following a noxious somatic stimulus. Catecholamines 218-231 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 171-176 8292052-0 1994 Stimulatory effect of IL-1 beta on catecholamine secretion from cultured bovine adrenal medullary cells. Catecholamines 35-48 interleukin 1 beta Bos taurus 22-31 8156394-0 1994 Brain catecholamines mediate the delayed reduction in renin release after injection of fenfluramine. Catecholamines 6-20 renin Rattus norvegicus 54-59 8292052-1 1994 We investigated the effect of recombinant human interleukin-1 beta (IL-1 beta) on catecholamine secretion from cultured bovine adrenal medullary cells. Catecholamines 82-95 interleukin 1 beta Homo sapiens 48-66 8137175-0 1994 Astrocytes and catalase prevent the toxicity of catecholamines to oligodendrocytes. Catecholamines 48-62 catalase Rattus norvegicus 15-23 8292052-1 1994 We investigated the effect of recombinant human interleukin-1 beta (IL-1 beta) on catecholamine secretion from cultured bovine adrenal medullary cells. Catecholamines 82-95 interleukin 1 beta Homo sapiens 68-77 8137175-3 1994 The catecholamine toxicity, reproduced by equimolar concentrations of H2O2, could be completely prevented by simultaneous treatment of OLs with the H2O2-decomposing enzyme catalase. Catecholamines 4-17 catalase Rattus norvegicus 172-180 8292052-2 1994 Treatment of cultured cells with IL-1 beta (10 ng/ml) for 24 hr caused an increase in accumulation of catecholamines in the cultured medium. Catecholamines 102-116 interleukin 1 beta Bos taurus 33-42 8292052-3 1994 The accumulation of catecholamines stimulated by IL-1 beta was observed in time (4-48 hr)- and concentration (3-30 ng/ml)-dependent manners. Catecholamines 20-34 interleukin 1 beta Bos taurus 49-58 8292052-6 1994 These results suggest that IL-1 beta stimulates catecholamine secretion through activation of IL-1 receptors in adrenal medullary cells. Catecholamines 48-61 interleukin 1 beta Bos taurus 27-36 7903902-1 1994 Projections of catecholamine neurons to the bed nucleus of the stria terminalis (BST), especially its corticotropin releasing factor (CRF)-producing neurons, are implicated as being major contributors to the neurochemically mediated central regulation of the stress response. Catecholamines 15-28 corticotropin releasing hormone Rattus norvegicus 102-132 7903970-2 1994 We reported recently that hypoxia stimulates gene expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis in type I cells of the carotid body. Catecholamines 120-133 tyrosine hydroxylase Rattus norvegicus 65-85 7903970-2 1994 We reported recently that hypoxia stimulates gene expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis in type I cells of the carotid body. Catecholamines 120-133 tyrosine hydroxylase Rattus norvegicus 87-89 8175918-3 1994 UCP gene expression, which was virtually undetectable under basic conditions, was stimulated by acute catecholamine or cyclic AMP treatment to levels comparable to primary cultures of brown adipocytes. Catecholamines 102-115 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 0-3 8131222-7 1994 The inhibition (expressed as a % of control) after incubating 0.5 microM GST in the presence of 100 units/ml tyrosinase with 5 microM of the catecholamines for 10 min at 25 degrees, was 99% and 67% for dopamine and alpha-methyldopa, respectively. Catecholamines 141-155 tyrosinase Homo sapiens 109-119 8175918-8 1994 From pharmacological evidence we conclude that beta 3-adrenergic receptors account for approximately 30-40% of catecholamine induced UCP gene stimulation, whereas about 60-70% is stimulated via the classical beta 1/2 adrenergic pathway. Catecholamines 111-124 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 133-136 8298261-2 1994 The purpose of these experiments was twofold: first, to study the relationship between plasma catecholamines and rCBF to determine if increased concentrations of plasma catecholamines were responsible for the increase in rCBF observed during insulin-induced hypoglycemia, and second, to study changes in rCBF after recovery from hypoglycemia. Catecholamines 169-183 CCAAT/enhancer binding protein zeta Rattus norvegicus 221-225 8298261-2 1994 The purpose of these experiments was twofold: first, to study the relationship between plasma catecholamines and rCBF to determine if increased concentrations of plasma catecholamines were responsible for the increase in rCBF observed during insulin-induced hypoglycemia, and second, to study changes in rCBF after recovery from hypoglycemia. Catecholamines 169-183 CCAAT/enhancer binding protein zeta Rattus norvegicus 221-225 8298261-18 1994 The dissociation of rCBF and plasma catecholamines casts doubt on the hypothesis that plasma catecholamines are responsible for increases in rCBF. Catecholamines 93-107 CCAAT/enhancer binding protein zeta Rattus norvegicus 141-145 7862266-6 1994 Our data suggest that only TRH clearly augments blood pressure and catecholamine secretion in the anesthetized animal, while CRH does not exert major effects under the two anesthetic conditions employed. Catecholamines 67-80 thyrotropin releasing hormone Rattus norvegicus 27-30 7760523-0 1994 Changes in plasma catecholamines during fever induced by bacterial endotoxin and interleukin-1 beta. Catecholamines 18-32 interleukin 1 beta Homo sapiens 81-99 7760523-4 1994 Pretreatment with intravenous indomethacin (1 mg/kg) markedly suppressed the increase in catecholamines induced by LPS and rIL-1 beta. Catecholamines 89-103 interleukin 1 beta Rattus norvegicus 123-133 7760523-7 1994 These results suggest that IL-1 acts via prostaglandins on the peripheral tissues to release catecholamines into the circulation. Catecholamines 93-107 interleukin 1 beta Homo sapiens 27-31 8190005-0 1994 Growth hormone increases the lipolytic sensitivity for catecholamines in adipocytes from healthy adults. Catecholamines 55-69 growth hormone 1 Homo sapiens 0-14 8301594-8 1994 In the aorta, depletion of catecholamines by reserpine pretreatment paradoxically augmented cocaine-induced HSP70 expression. Catecholamines 27-41 heat shock protein family A (Hsp70) member 4 Homo sapiens 108-113 8272186-8 1993 It appears that for the dog, deamination of catecholamines is controlled by MAO-A. Catecholamines 44-58 monoamine oxidase A Canis lupus familiaris 76-81 8267623-2 1993 PEC-60-like immunoreactivity is found in catecholamine neurons and intracerebroventricular injections of PEC-60 reduce dopamine utilization within the caudate nucleus indicating a possible role of this peptide in the central nervous system. Catecholamines 41-54 serine peptidase inhibitor, Kazal type 4 Rattus norvegicus 0-6 8015978-2 1994 Recently, an interior fragment of CgA [CgA(124-143)], also called chromostatin, was reported to suppress catecholamine release from chromaffin cells in vitro. Catecholamines 105-118 chromogranin A Rattus norvegicus 34-37 8015978-2 1994 Recently, an interior fragment of CgA [CgA(124-143)], also called chromostatin, was reported to suppress catecholamine release from chromaffin cells in vitro. Catecholamines 105-118 chromogranin A Rattus norvegicus 39-42 8036617-10 1994 Our results suggest that MAO activity in rat reproductive organs such as uterus, ovary, and placenta might fluctuate significantly near term, in correlation with steroid levels, tissue catecholamine contents and so on, in order to maintain pregnancy. Catecholamines 185-198 monoamine oxidase A Rattus norvegicus 25-28 8258340-10 1993 The results of the present study lend support to the hypothesis that catecholamines, via beta 2-adrenergic receptors, can induce recruitment of NK cells from the marginating pool to the circulating pool, by changing the adhesive interactions between NK cells and EC. Catecholamines 69-83 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 89-95 7504087-1 1993 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 77-91 tyrosine hydroxylase Gallus gallus 0-20 7504087-1 1993 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. Catecholamines 77-91 tyrosine hydroxylase Gallus gallus 22-24 7909954-1 1993 The present study was undertaken to determine if gene expression for tyrosine hydroxylase (TH), the rate limiting enzyme in the biosynthesis of catecholamines, is regulated in the carotid body, sympathetic ganglia and adrenal medulla by hypoxia. Catecholamines 144-158 tyrosine hydroxylase Homo sapiens 69-89 7909954-1 1993 The present study was undertaken to determine if gene expression for tyrosine hydroxylase (TH), the rate limiting enzyme in the biosynthesis of catecholamines, is regulated in the carotid body, sympathetic ganglia and adrenal medulla by hypoxia. Catecholamines 144-158 tyrosine hydroxylase Homo sapiens 91-93 7909954-5 1993 Our results show that TH gene expression is regulated by hypoxia in the carotid body but not in other peripheral catecholamine synthesizing tissue and that the regulatory mechanism is intrinsic to type I cells. Catecholamines 113-126 tyrosine hydroxylase Homo sapiens 22-24 7901211-2 1993 Nicotine, a major component of tobacco smoke, stimulates catecholamine secretion and activates catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medullary cells. Catecholamines 95-108 tyrosine hydroxylase Rattus norvegicus 138-158 7904615-1 1993 Aromatic L-amino acid decarboxylase (AAAD) is the second enzyme in the sequence leading to the synthesis of catecholamines or serotonin. Catecholamines 108-122 dopa decarboxylase Mus musculus 0-35 7904615-1 1993 Aromatic L-amino acid decarboxylase (AAAD) is the second enzyme in the sequence leading to the synthesis of catecholamines or serotonin. Catecholamines 108-122 dopa decarboxylase Mus musculus 37-41 8226929-1 1993 Wild type PC12 pheochromocytoma cells express a Na(+)-dependent norepinephrine transporter that operates in the uptake of catecholamines, including dopamine. Catecholamines 122-136 solute carrier family 6 member 2 Rattus norvegicus 64-90 7901211-2 1993 Nicotine, a major component of tobacco smoke, stimulates catecholamine secretion and activates catecholamine biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in adrenal medullary cells. Catecholamines 95-108 dopamine beta-hydroxylase Rattus norvegicus 195-198 7902002-3 1993 We hypothesized that insulin-induced catecholamine-mediated beta-adrenergic stimulation supports some of these hemodynamic changes in the hyperinsulinemic ovine fetus. Catecholamines 37-50 insulin Homo sapiens 21-28 8252754-3 1993 These findings provide the first evidence that insulin receptor mRNA levels may be modulated in vivo by high levels of catecholamines. Catecholamines 119-133 insulin receptor Homo sapiens 47-63 7902002-8 1993 We conclude that in the hyperinsulinemic-hypoglycemic normoxemic ovine fetus, insulin-induced catecholamine-mediated hemodynamic changes are modulated in part by beta-adrenergic receptor stimulation. Catecholamines 94-107 insulin Homo sapiens 29-36 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 0-28 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-119 catechol-O-methyltransferase Homo sapiens 30-34 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-118 catechol-O-methyltransferase Homo sapiens 0-28 12959293-2 1993 Catechol-O-methyltransferase (COMT) inhibition might be assumed to potentiate the effects of circulating catecholamines, particularly under conditions of enhanced catecholamine release. Catecholamines 105-118 catechol-O-methyltransferase Homo sapiens 30-34 12959293-4 1993 The purpose of the present study was to establish whether the novel COMT inhibitor, entacapone, changes haemodynamic responses and catecholamine metabolism during exercise. Catecholamines 131-144 catechol-O-methyltransferase Homo sapiens 68-72 12959293-12 1993 However, it altered the metabolic profile of catecholamines, which was shown by increases in the plasma concentrations of the monoamine oxidase-dependent metabolites DHPG (by up to 100%) and DOPAC (by up to 53%), and by a decrease of the COMT-dependent metabolite MHPG (by up to 29%). Catecholamines 45-59 catechol-O-methyltransferase Homo sapiens 238-242 8112501-8 1993 The possible use of liposome-entrapped tyrosinase to raise L-DOPA levels in catecholamine related disorders is discussed. Catecholamines 76-89 tyrosinase Rattus norvegicus 39-49 8114953-0 1993 Both beta 1- and beta 2-adrenoceptors mediate catecholamine-evoked arrhythmias in isolated human right atrium. Catecholamines 46-59 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 5-23 8114953-1 1993 The involvement of beta 1- and beta 2-adrenoceptors in catecholamine-evoked arrhythmias was investigated in isolated human right atrial appendages obtained from 22 patients chronically treated with beta blockers (usually beta 1-selective) and 9 patients not treated with beta blockers. Catecholamines 55-68 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 19-37 8230093-2 1993 In previous papers dealing with the study of the conformations and the biopharmacological activity of conformationally restrained analogs of sympathomimetic catecholamines (NE and ISO), proposals were advanced for the three-dimensional molecular models A, B, and C; these models provided information about the steric requirements for the direct activation of alpha 1, alpha 2,beta 1, and beta 2 adrenoceptors, respectively. Catecholamines 157-171 adrenoceptor alpha 1D Homo sapiens 359-394 7902953-1 1993 The neuropeptide vasoactive intestinal polypeptide (VIP) increases the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, in cultured chicken sympathetic neurons. Catecholamines 158-172 vasoactive intestinal peptide Gallus gallus 52-55 7902953-1 1993 The neuropeptide vasoactive intestinal polypeptide (VIP) increases the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, in cultured chicken sympathetic neurons. Catecholamines 158-172 tyrosine hydroxylase Gallus gallus 83-103 7902953-1 1993 The neuropeptide vasoactive intestinal polypeptide (VIP) increases the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamines, in cultured chicken sympathetic neurons. Catecholamines 158-172 tyrosine hydroxylase Gallus gallus 105-107 7904926-11 1993 Our results suggest that atrial natriuretic factor effects on noradrenaline release, evoked by angiotensin II, III and KCl, may be involved in the regulation of the central catecholamine pathways and sympathetic activity. Catecholamines 173-186 natriuretic peptide A Rattus norvegicus 25-50 7904926-11 1993 Our results suggest that atrial natriuretic factor effects on noradrenaline release, evoked by angiotensin II, III and KCl, may be involved in the regulation of the central catecholamine pathways and sympathetic activity. Catecholamines 173-186 angiotensinogen Rattus norvegicus 95-109 8405291-1 1993 The activity of three catecholamine-metabolizing enzymes, monoamine oxidase type A and type B (MAO-A and MAO-B) as well as catechol-O-methyltransferase (COMT), were estimated in homogenates of human spinal cord using radiometric assays. Catecholamines 22-35 monoamine oxidase A Homo sapiens 58-93 8104777-2 1993 We have examined the effects of suckling on TIDA activity in the arcuate nucleus by measuring changes in gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 179-192 tyrosine hydroxylase Rattus norvegicus 124-144 8104777-2 1993 We have examined the effects of suckling on TIDA activity in the arcuate nucleus by measuring changes in gene expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Catecholamines 179-192 tyrosine hydroxylase Rattus norvegicus 146-148 8215065-0 1993 Relationship of parotid saliva C-reactive protein to catecholamine release. Catecholamines 53-66 C-reactive protein Homo sapiens 31-49 7507911-3 1993 Here we briefly review the mechanisms by which one such agent (the neuropeptide substance P) modulates the cholinergic secretory response of adrenal chromaffin cells, and another agent (angiotensin II) elicits catecholamine secretion independently of the cholinergic innervation. Catecholamines 210-223 angiotensinogen Homo sapiens 186-200 8292490-5 1993 Increased intracellular calcium by the ionophore A23187 ranging from 50 to 500 nM caused DBH mRNA to decrease, which began to be observed after 6 h and was undetectable by 48 h. The results demonstrate the existence of coordinate and differential regulations among the enzymes involved in catecholamine biosynthesis in bovine adrenomedullary cells. Catecholamines 289-302 dopamine beta-hydroxylase Bos taurus 89-92 8287440-2 1993 Vasopressin is an abundantly available neuropeptide having well known interactions with catecholamines in vascular smooth muscle. Catecholamines 88-102 arginine vasopressin Rattus norvegicus 0-11 8362843-8 1993 In this case, the effect of stress on serum gastrin mimicked the effect of catecholamine infusion in ZES. Catecholamines 75-88 gastrin Homo sapiens 44-51 7903945-1 1993 The activity of the rate-limiting enzyme of catecholamine synthesis--the tyrosine hydroxylase (TH) increased in the brain of 20-day-old fetuses of the Wistar strain and aggressive gray rats, 6 hours after corticosterone injection to their mothers. Catecholamines 44-57 tyrosine hydroxylase Rattus norvegicus 73-93 7903945-1 1993 The activity of the rate-limiting enzyme of catecholamine synthesis--the tyrosine hydroxylase (TH) increased in the brain of 20-day-old fetuses of the Wistar strain and aggressive gray rats, 6 hours after corticosterone injection to their mothers. Catecholamines 44-57 tyrosine hydroxylase Rattus norvegicus 95-97 8375616-3 1993 The rank order of potency of ligands to inhibit nicotine-stimulated catecholamine release is significantly correlated (P < 0.005) with that observed in radioligand binding assays selective for the sigma 1 receptor subtype. Catecholamines 68-81 sigma non-opioid intracellular receptor 1 Bos taurus 200-216 8103077-1 1993 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the reduced pteridine cofactor required for catecholamine (CA), indoleamine, and nitric oxide biosynthesis. Catecholamines 145-158 GTP cyclohydrolase 1 Rattus norvegicus 0-20 8103077-1 1993 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, the reduced pteridine cofactor required for catecholamine (CA), indoleamine, and nitric oxide biosynthesis. Catecholamines 145-158 GTP cyclohydrolase 1 Rattus norvegicus 22-27 8103077-5 1993 Levels of GTPCH mRNA in central and peripheral catecholamine neurons determined by nuclease protection assay were increased twofold 24 h after a single injection of the CA-depleting drug reserpine; both the 1.2- and 3.8-kb transcripts were increased in the adrenal gland. Catecholamines 47-60 GTP cyclohydrolase 1 Rattus norvegicus 10-15 8284275-1 1993 Neurotensin (NT) is coexpressed with catecholamines in sympathetic neurons and adrenal chromaffin cells. Catecholamines 37-51 neurotensin Rattus norvegicus 0-11 8284275-1 1993 Neurotensin (NT) is coexpressed with catecholamines in sympathetic neurons and adrenal chromaffin cells. Catecholamines 37-51 neurotensin Rattus norvegicus 13-15 8394336-0 1993 Epidermal growth factor modulates the lipolytic action of catecholamines in rat adipocytes. Catecholamines 58-72 epidermal growth factor like 1 Rattus norvegicus 0-23 8076058-9 1993 catecholamine dosage was significantly less in the leucocyte-depleted group than in controls (1.1(1.9) versus 4.9(2.2) micrograms kg-1 min-1; P < 0.05), whereas the cardiac index was significantly higher (3.3(0.5) versus 2.3(0.4) l min-1 m-2; P < 0.05). Catecholamines 0-13 CD59 molecule (CD59 blood group) Homo sapiens 135-140 8405129-3 1993 Perfusion with 1-10 microM D-myo-inositol 1,2,6-trisphosphate (alpha-trinositol) reduced, in a concentration-dependent fashion, the neuropeptide Y-induced potentiation of the noradrenaline-evoked vasoconstriction without altering the potency or maximal response evoked by the catecholamine alone. Catecholamines 276-289 neuropeptide Y Rattus norvegicus 132-146 8076058-9 1993 catecholamine dosage was significantly less in the leucocyte-depleted group than in controls (1.1(1.9) versus 4.9(2.2) micrograms kg-1 min-1; P < 0.05), whereas the cardiac index was significantly higher (3.3(0.5) versus 2.3(0.4) l min-1 m-2; P < 0.05). Catecholamines 0-13 CD59 molecule (CD59 blood group) Homo sapiens 235-240 8394383-4 1993 Chromaffin cell secretagogues (0.1 mM nicotinic cholinergic agonist, 55 mM K+, or 2 mM Ba++) caused cosecretion of human CgA and catecholamines from human CgA-expressing cells. Catecholamines 129-143 chromogranin A Homo sapiens 155-158 8228731-11 1993 TRH challenge occurred in birds pretreated with reserpine (a catecholamine depletor), alpha-methyl-paratyrosine (a DA synthesis inhibitor) and pimozide (a DA receptor antagonist). Catecholamines 61-74 thyrotropin releasing hormone Homo sapiens 0-3 8393882-4 1993 The beta 3-AR has been reported to mediate catecholamine-induced cAMP accumulation and to be more responsive in this regard than either the beta 1- or the beta 2-AR. Catecholamines 43-56 adrenoceptor beta 3 Homo sapiens 4-13 8406464-1 1993 Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension. Catecholamines 62-76 chromogranin A Rattus norvegicus 0-14 8393882-5 1993 To examine the possibility that a beta 3-AR plays a significant role in the control of catecholamine-stimulated lipolysis in human adipose tissue, we used a sensitive in vitro measure of lipolysis. Catecholamines 87-100 adrenoceptor beta 3 Homo sapiens 34-43 8401564-1 1993 Chromogranin A (CGA) belongs to a family of highly acidic proteins which are co-stored and co-released with the catecholamines from the mammalian adrenal gland and occur in nmolar concentrations in the human circulation. Catecholamines 112-126 chromogranin A Homo sapiens 0-14 8401564-1 1993 Chromogranin A (CGA) belongs to a family of highly acidic proteins which are co-stored and co-released with the catecholamines from the mammalian adrenal gland and occur in nmolar concentrations in the human circulation. Catecholamines 112-126 chromogranin A Homo sapiens 16-19 8248005-6 1993 It is suggested that the pesticide effects on motor function are consequences of the inhibitory effects on MAO activity, most probably through the increases produced on catecholamine levels within the central nervous system. Catecholamines 169-182 monoamine oxidase A Rattus norvegicus 107-110 8325848-10 1993 The variability in the occurrence of the pre-spike feature suggests it originates from free catecholamine within the vesicle, since the molar fraction bound by the vesicular matrix is regulated by the pH-dependent conformation and Ca(2+)-dependent binding affinity of chromogranin A, a major protein in the vesicle. Catecholamines 92-105 chromogranin A Bos taurus 268-282 7686903-10 1993 Moreover, specific antibodies raised against the carboxyl terminus of G(o) alpha reversed in a dose-dependent manner the inhibition by mastoparan on catecholamine release and the stimulation by mastoparan of chromaffin granule-associated G proteins. Catecholamines 149-162 tripartite motif containing 47 Homo sapiens 70-80 8243716-7 1993 The obtained results show that catecholamines participate in activation of heparin release from mast cells induced both by the stress and by thrombin injection. Catecholamines 31-45 coagulation factor II Rattus norvegicus 141-149 8369734-7 1993 The results suggested that NPY was co-released with CAs from chromaffin cells and then acted as a modulator on CA secretion. Catecholamines 52-55 neuropeptide Y Rattus norvegicus 27-30 8103115-4 1993 Concomitantly, RA reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and the level of norepinephrine (NE). Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 90-110 8103115-4 1993 Concomitantly, RA reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and the level of norepinephrine (NE). Catecholamines 57-70 tyrosine hydroxylase Rattus norvegicus 112-114 8103115-4 1993 Concomitantly, RA reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and the level of norepinephrine (NE). Catecholamines 57-70 dopamine beta-hydroxylase Rattus norvegicus 120-145 8103115-4 1993 Concomitantly, RA reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and the level of norepinephrine (NE). Catecholamines 57-70 dopamine beta-hydroxylase Rattus norvegicus 147-150 8031723-1 1993 The present study was conducted to investigate the influence of arachidonic acid, which is known to be an important unsaturated fatty acid component of membrane phospholipids and to be liberated by phospholipase A2 action, on secretion of catecholamines (CA) from the isolated perfused rat adrenal glands and to clarify the mechanism of its action. Catecholamines 239-253 phospholipase A2 group IB Rattus norvegicus 198-214 8264849-1 1993 Central catecholamines (CA) are known to be involved in the regulation of synthesis and secretion of gonadotropin releasing hormone (GnRH) from the hypothalamus. Catecholamines 8-22 gonadotropin releasing hormone 1 Rattus norvegicus 101-131 8264849-1 1993 Central catecholamines (CA) are known to be involved in the regulation of synthesis and secretion of gonadotropin releasing hormone (GnRH) from the hypothalamus. Catecholamines 8-22 gonadotropin releasing hormone 1 Rattus norvegicus 133-137 8371057-8 1993 The affinity of the beta 3-adrenoceptor for catecholamines is less than that of the classical beta 1- and beta 2-adrenoceptors. Catecholamines 44-58 adrenoceptor beta 3 Homo sapiens 20-39 8264854-2 1993 The subpopulation of corticotropin-releasing hormone (CRH) neurosecretory cells that contains vasopressin (VP) is selectively activated by several types of stress (immobilization, hypoglycemia, and intracerebroventricular, i.c.v., colchicine), and is located in a catecholamine-rich area of the hypothalamic paraventricular nucleus. Catecholamines 264-277 corticotropin releasing hormone Rattus norvegicus 21-52 8264854-2 1993 The subpopulation of corticotropin-releasing hormone (CRH) neurosecretory cells that contains vasopressin (VP) is selectively activated by several types of stress (immobilization, hypoglycemia, and intracerebroventricular, i.c.v., colchicine), and is located in a catecholamine-rich area of the hypothalamic paraventricular nucleus. Catecholamines 264-277 corticotropin releasing hormone Rattus norvegicus 54-57 8264854-2 1993 The subpopulation of corticotropin-releasing hormone (CRH) neurosecretory cells that contains vasopressin (VP) is selectively activated by several types of stress (immobilization, hypoglycemia, and intracerebroventricular, i.c.v., colchicine), and is located in a catecholamine-rich area of the hypothalamic paraventricular nucleus. Catecholamines 264-277 arginine vasopressin Rattus norvegicus 94-105 8264854-2 1993 The subpopulation of corticotropin-releasing hormone (CRH) neurosecretory cells that contains vasopressin (VP) is selectively activated by several types of stress (immobilization, hypoglycemia, and intracerebroventricular, i.c.v., colchicine), and is located in a catecholamine-rich area of the hypothalamic paraventricular nucleus. Catecholamines 264-277 arginine vasopressin Rattus norvegicus 107-109 8356302-6 1993 Previously we have shown that in congestive diseases there is a relation between ANF and catecholamine secretion. Catecholamines 89-102 natriuretic peptide A Homo sapiens 81-84 8400589-9 1993 Anabolic IGF-1 and insulin levels showed significant negative correlation with the catabolic indicators 3-methylhistidine and catecholamine excretion. Catecholamines 126-139 insulin like growth factor 1 Homo sapiens 9-14 8400589-9 1993 Anabolic IGF-1 and insulin levels showed significant negative correlation with the catabolic indicators 3-methylhistidine and catecholamine excretion. Catecholamines 126-139 insulin Homo sapiens 19-26 8102600-2 1993 For this aim, "long-survival" [3H]thymidine autoradiography was used in combination with immunocytochemistry of TH, the first enzyme of catecholamine synthesis. Catecholamines 136-149 tyrosine hydroxylase Rattus norvegicus 112-114 8394164-7 1993 The effects of catecholamines appear to be mediated at the level of antigen processing/presentation: Amphetamine given prior to sacrifice inhibited interleukin 2 production when irradiated spleen cells were used to present HEL and HEL-related peptides to HEL-specific T-cell hybridomas. Catecholamines 15-29 interleukin 2 Mus musculus 148-161 8513278-3 1993 The reported co-existence of CCK and dopamine in some meso-limbic neurons has led to speculation that the neuropeptide may interact with the catecholamine in neuropsychopathologies linked to dopamine dysfunctions, like schizophrenia. Catecholamines 141-154 cholecystokinin Rattus norvegicus 29-32 8099794-8 1993 The enzymes involved in catecholamine biosynthesis, including PNMT and tyrosine hydroxylase, were identified immunocytochemically in the tumor. Catecholamines 24-37 phenylethanolamine N-methyltransferase Homo sapiens 62-66 8100544-2 1993 The catecholamine-containing cells were identified using antisera against enzymes of catecholamine synthesis (tyrosine-hydroxylase, dopamine-beta-hydroxylase, and phenylethanolamine-N-methyl-transferase). Catecholamines 4-17 dopamine beta-hydroxylase Homo sapiens 132-157 8100046-13 1993 Based on previous data reporting a lack of dopamine-beta-hydroxylase-like immunoreactivity within the organ of Corti, and the effectiveness of a D2 agonist on the cochlear compound action potential of the auditory nerve, this catecholamine could well be dopamine. Catecholamines 226-239 dopamine beta-hydroxylase Cavia porcellus 43-68 8482451-1 1993 BACKGROUND: Catechol-O-methyltransferase (COMT) inhibition prevents tissue degradation of catecholamines including dopamine. Catecholamines 90-104 catechol-O-methyltransferase Homo sapiens 12-40 8482451-1 1993 BACKGROUND: Catechol-O-methyltransferase (COMT) inhibition prevents tissue degradation of catecholamines including dopamine. Catecholamines 90-104 catechol-O-methyltransferase Homo sapiens 42-46 8321395-1 1993 Several lines of evidence link chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, with the cholinergic nervous system, abnormalities of which may play a central role in memory deficits in Alzheimer dementia. Catecholamines 82-95 chromogranin A Homo sapiens 31-45 8321395-1 1993 Several lines of evidence link chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, with the cholinergic nervous system, abnormalities of which may play a central role in memory deficits in Alzheimer dementia. Catecholamines 82-95 chromogranin A Homo sapiens 47-50 7682702-2 1993 MR22 and REC17 are 371 and 357 amino acids long, respectively, as deduced from nucleotide sequence and share 68% mutual amino acid identity and 30-35% identity with known catecholamine and 5-HT receptors. Catecholamines 171-184 5-hydroxytryptamine (serotonin) receptor 5B Rattus norvegicus 0-4 7682705-1 1993 Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine to 3,4-dihydroxy-L-phenylalanine, the first and rate-limiting step in catecholamine biosynthesis. Catecholamines 135-148 tyrosine hydroxylase Rattus norvegicus 0-20 7682702-2 1993 MR22 and REC17 are 371 and 357 amino acids long, respectively, as deduced from nucleotide sequence and share 68% mutual amino acid identity and 30-35% identity with known catecholamine and 5-HT receptors. Catecholamines 171-184 5-hydroxytryptamine (serotonin) receptor 5B Rattus norvegicus 9-14 7682705-1 1993 Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine to 3,4-dihydroxy-L-phenylalanine, the first and rate-limiting step in catecholamine biosynthesis. Catecholamines 135-148 tyrosine hydroxylase Rattus norvegicus 22-24 8481799-4 1993 Although LHRH-catecholamine synapses are established before or at birth, whether such synapses are functional remains to be resolved. Catecholamines 14-27 gonadotropin releasing hormone 1 Rattus norvegicus 9-13 7681672-0 1993 Substance P inhibits catecholamine biosynthesis stimulated by carbamylcholine in cultured adrenal chromaffin cells. Catecholamines 21-34 tachykinin precursor 1 Bos taurus 0-11 8386972-0 1993 Evaluation for roles of brain prostaglandins in the catecholamine-induced vasopressin secretion in conscious rats. Catecholamines 52-65 arginine vasopressin Rattus norvegicus 74-85 8097943-0 1993 Endogenous catecholamines modulate growth hormone release in the conscious rat during hypoglycaemia but not in the basal state. Catecholamines 11-25 gonadotropin releasing hormone receptor Rattus norvegicus 35-49 8384992-7 1993 In conclusion, these and previous results suggest that the testosterone-induced increase in lipolytic response to catecholamines in rat white adipocytes is mediated through several events including an increased beta-adrenergic receptor density, probably an increased adenylate cyclase activity and an increased protein kinase A/hormone sensitive lipase activity at the postreceptor level with apparent absence of effect on the expression of G-proteins. Catecholamines 114-128 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 311-327 8384992-7 1993 In conclusion, these and previous results suggest that the testosterone-induced increase in lipolytic response to catecholamines in rat white adipocytes is mediated through several events including an increased beta-adrenergic receptor density, probably an increased adenylate cyclase activity and an increased protein kinase A/hormone sensitive lipase activity at the postreceptor level with apparent absence of effect on the expression of G-proteins. Catecholamines 114-128 lipase E, hormone sensitive type Rattus norvegicus 328-352 8384995-0 1993 Ca(2+)-dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells. Catecholamines 93-106 adenylate cyclase activating polypeptide 1 Homo sapiens 39-89 8384995-1 1993 Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates catecholamine secretion from cultured porcine adrenal medullary chromaffin cells in a dose-dependent manner with the half-maximal and maximal doses of 30 nM and 1 microM, respectively. Catecholamines 70-83 adenylate cyclase activating polypeptide 1 Homo sapiens 0-50 8384995-1 1993 Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates catecholamine secretion from cultured porcine adrenal medullary chromaffin cells in a dose-dependent manner with the half-maximal and maximal doses of 30 nM and 1 microM, respectively. Catecholamines 70-83 adenylate cyclase activating polypeptide 1 Homo sapiens 52-57 8384995-2 1993 Either removal of extracellular Ca2+ or addition of Gd3+, an inorganic Ca2+ channel blocker, very potently inhibits PACAP-induced catecholamine secretion. Catecholamines 130-143 adenylate cyclase activating polypeptide 1 Homo sapiens 116-121 8384995-3 1993 Both nicardipine (1 microM) and methoxyverapamil (1 microM), blockers of voltage-dependent Ca2+ channels, are also effective in inhibiting PACAP-induced catecholamine secretion. Catecholamines 153-166 adenylate cyclase activating polypeptide 1 Homo sapiens 139-144 8384995-7 1993 Removal of extracellular Ca2+ enhances PACAP-induced cAMP production but strongly inhibits PACAP-induced catecholamine secretion. Catecholamines 105-118 adenylate cyclase activating polypeptide 1 Homo sapiens 91-96 8384995-10 1993 These results indicate that PACAP activates voltage-dependent Ca2+ channels and phospholipase C as well as adenylate cyclase in cultured porcine adrenal medullary cells and strongly suggest that PACAP-induced catecholamine secretion is mainly mediated by activation of voltage-dependent Ca2+ channels. Catecholamines 209-222 adenylate cyclase activating polypeptide 1 Homo sapiens 28-33 8384995-10 1993 These results indicate that PACAP activates voltage-dependent Ca2+ channels and phospholipase C as well as adenylate cyclase in cultured porcine adrenal medullary cells and strongly suggest that PACAP-induced catecholamine secretion is mainly mediated by activation of voltage-dependent Ca2+ channels. Catecholamines 209-222 adenylate cyclase activating polypeptide 1 Homo sapiens 195-200 8469920-9 1993 Humoral factors have been suggested as regulators of ANF release, particularly catecholamines and angiotensin II. Catecholamines 79-93 natriuretic peptide A Homo sapiens 53-56 8469920-11 1993 Circulating catecholamines and angiotensin II stimulate ANF release mainly through their haemodynamic effects. Catecholamines 12-26 natriuretic peptide A Homo sapiens 56-59 8095939-1 1993 The distribution of dopamine beta-hydroxylase and tyrosine hydroxylase, two key enzymes in the biosynthesis of catecholamines, was investigated by immunocytochemistry in the brain of male and female Japanese quail. Catecholamines 111-125 dopamine beta-hydroxylase Coturnix japonica 20-45 7681672-1 1993 The effect of substance P on catecholamine biosynthesis was examined using cultured bovine adrenal chromaffin cells as a model for the sympathoadrenergic system. Catecholamines 29-42 tachykinin precursor 1 Bos taurus 14-25 7681672-4 1993 Under the conditions in which the inhibition of catecholamine biosynthesis was observed, substance P also inhibited the influx of extracellular 45Ca2+ into these cells, and this inhibitory action on Ca2+ influx was almost identical to that on the biosynthesis. Catecholamines 48-61 tachykinin precursor 1 Bos taurus 89-100 8386030-7 1993 A survey of other neuropeptides and catecholamines indicated that the addition of ACTH or epinephrine to macrophage cultures resulted in a suppression of I-A expression. Catecholamines 36-50 pro-opiomelanocortin-alpha Mus musculus 82-86 8402382-11 1993 These effects of atrial natriuretic factor may be related to the catecholamine peripheral mechanism involved in the regulation of arterial blood pressure, smooth muscle tone, metabolic activity, etc. Catecholamines 65-78 natriuretic peptide A Rattus norvegicus 17-42 8402396-1 1993 The present study was conducted to investigate local effects of endothelin-1 (ET-1) on basal adrenal catecholamine (CA) secretion and underlying mechanisms of action of ET-1 in anesthetized dogs. Catecholamines 101-114 endothelin 1 Canis lupus familiaris 64-76 8484015-5 1993 These results suggest that EGF interfered with catecholamine actions in the liver at a site distal from the generation of the calcium signal. Catecholamines 47-60 epidermal growth factor like 1 Rattus norvegicus 27-30 8382265-5 1993 FTX or nitrendipine reduced adrenaline and noradrenaline release by approximately 80 and 70%, respectively, but both substances together abolished the K(+)-evoked catecholamine release, as measured by HPLC. Catecholamines 163-176 FTX transcript, XIST regulator Homo sapiens 0-3 8510498-1 1993 Dopamine beta-hydroxylase (DBH, EC 1.14.17.1) catalyzes the conversion of dopamine to norepinephrine, the third step of catecholamine biosynthesis. Catecholamines 120-133 dopamine beta-hydroxylase Homo sapiens 0-25 8510498-1 1993 Dopamine beta-hydroxylase (DBH, EC 1.14.17.1) catalyzes the conversion of dopamine to norepinephrine, the third step of catecholamine biosynthesis. Catecholamines 120-133 dopamine beta-hydroxylase Homo sapiens 27-30 8097474-2 1993 After 1 week in vitro, cultures of 18-h clusters grown with the RBM gel overlay exhibited a 60-fold increase in the number of catecholamine-positive cells, while the number of melanocytes was decreased to one-quarter the control value. Catecholamines 126-139 RNA binding motif protein Y-linked family 1 member A1 Homo sapiens 64-67 8402396-1 1993 The present study was conducted to investigate local effects of endothelin-1 (ET-1) on basal adrenal catecholamine (CA) secretion and underlying mechanisms of action of ET-1 in anesthetized dogs. Catecholamines 101-114 endothelin 1 Canis lupus familiaris 78-82 8382265-0 1993 A toxin fraction (FTX) from the funnel-web spider poison inhibits dihydropyridine-insensitive Ca2+ channels coupled to catecholamine release in bovine adrenal chromaffin cells. Catecholamines 119-132 FTX transcript, XIST regulator Homo sapiens 18-21 8382265-2 1993 We have now evaluated the sensitivity of the dihydropyridine-resistant components of Ca2+ influx and catecholamine release to a toxin fraction (FTX) from the funnel-web spider poison, which is known to block P-type channels in mammalian neurons. Catecholamines 101-114 FTX transcript, XIST regulator Homo sapiens 144-147 8382265-7 1993 Our results indicate that FTX blocks dihydropyridine- and omega-conotoxin-insensitive Ca2+ channels that, together with L-type voltage-sensitive Ca2+ channels, are coupled to catecholamine release. Catecholamines 175-188 FTX transcript, XIST regulator Homo sapiens 26-29 8479600-2 1993 Naphthalenesulfonamide derivatives as ML9 and ML7, more specific for the myosin light chain kinase, and the calmodulin antagonist W7 inhibited catecholamine secretion 20 and 40% respectively in digitonin-permeabilized chromaffin cells. Catecholamines 143-156 calmodulin Bos taurus 108-118 7716647-2 1993 Having the most and longest vasoconstrictor activity that has been described to date and ability to stimulate the release aldosterone, catecholamine and renin, endothelin-1 became the subject of many studies on its pathogenetic role in arterial hypertension. Catecholamines 135-148 endothelin 1 Homo sapiens 160-172 8098879-10 1993 Despite the general lack of beta-receptors in area CA3, abundant catecholamine immunoreactive fibers were observed in CA3 of rat and guinea pig hippocampus. Catecholamines 65-78 carbonic anhydrase 3 Rattus norvegicus 118-121 8095774-1 1993 The role of catecholamine neuronal systems in mediating the analeptic and thermogenic effects of thyrotropin-releasing hormone (TRH) was examined in long-sleep (LS) and short-sleep (SS) mice. Catecholamines 12-25 thyrotropin releasing hormone Mus musculus 97-126 8383904-1 1993 In several animal species the catecholamines stimulate the release of alpha-MSH from the melanotrope cells of the pituitary neurointermediate lobe through beta-receptors. Catecholamines 30-44 proopiomelanocortin Homo sapiens 70-79 8432989-2 1993 The IFN-gamma-induced surface expression of MHC class II molecules on those cells is stimulated by catecholamines through a cAMP-independent mechanism. Catecholamines 99-113 interferon gamma Bos taurus 4-13 8432989-3 1993 We report that both the induction of MHC class II molecule expression by IFN-gamma and its potentiation by isoproterenol, a catecholamine analog, are preceded by increases of steady-state levels of the corresponding mRNA. Catecholamines 124-137 interferon gamma Bos taurus 73-82 8095774-7 1993 Thus, there was an association between the ability of TRH to produce an activation of catecholamine neuronal systems (increased rate of catecholamine biosynthesis) and the analeptic action of TRH to reduce the CNS depressant effects of ethanol (decreased sleep times). Catecholamines 136-149 thyrotropin releasing hormone Mus musculus 54-57 8095774-7 1993 Thus, there was an association between the ability of TRH to produce an activation of catecholamine neuronal systems (increased rate of catecholamine biosynthesis) and the analeptic action of TRH to reduce the CNS depressant effects of ethanol (decreased sleep times). Catecholamines 136-149 thyrotropin releasing hormone Mus musculus 192-195 8095774-1 1993 The role of catecholamine neuronal systems in mediating the analeptic and thermogenic effects of thyrotropin-releasing hormone (TRH) was examined in long-sleep (LS) and short-sleep (SS) mice. Catecholamines 12-25 thyrotropin releasing hormone Mus musculus 128-131 8095774-5 1993 TRH (20 micrograms, icv) given alone produced an activation of central and peripheral catecholamine systems in LS, but not SS mice, as reflected by an increase in the in vivo tyrosine hydroxylase (TH) activity in the brain and adrenal gland. Catecholamines 86-99 thyrotropin releasing hormone Mus musculus 0-3 8095774-7 1993 Thus, there was an association between the ability of TRH to produce an activation of catecholamine neuronal systems (increased rate of catecholamine biosynthesis) and the analeptic action of TRH to reduce the CNS depressant effects of ethanol (decreased sleep times). Catecholamines 86-99 thyrotropin releasing hormone Mus musculus 54-57 8095774-7 1993 Thus, there was an association between the ability of TRH to produce an activation of catecholamine neuronal systems (increased rate of catecholamine biosynthesis) and the analeptic action of TRH to reduce the CNS depressant effects of ethanol (decreased sleep times). Catecholamines 86-99 thyrotropin releasing hormone Mus musculus 192-195 8425662-10 1993 In summary, the 6-fold higher insulin level resulted in significantly greater increases in catecholamine and cortisol secretion, HGP, lipolysis, heart rate, and sBP despite equivalent hypoglycemia. Catecholamines 91-104 insulin Homo sapiens 30-37 8097300-1 1993 Immunohistochemical study of catecholamine synthesizing enzymes tyrosine hydroxylase (TH) and phenylethanolamine-N-methyl transferase (PNMT) was performed in lower brain stem of 5 controls and 9 sudden infant death "syndrome" (SIDS) cases. Catecholamines 29-42 phenylethanolamine N-methyltransferase Homo sapiens 135-139 8382054-4 1993 In addition, a number of other adaptations in the beta-adrenergic signal-transduction system occur during the lactation cycle and in response to growth hormone treatment, including changes in receptor number, adenylate cyclase activity and cyclic AMP phosphodiesterase activity, but a defect in the ability of hormone-sensitive lipase to associate with the lipid droplet appears to be the major reason for the diminished response to catecholamines on litter removal. Catecholamines 433-447 gonadotropin releasing hormone receptor Rattus norvegicus 145-159 7678287-0 1993 Corticotropin-releasing factor stimulates catecholamine release in hypothalamus and prefrontal cortex in freely moving rats as assessed by microdialysis. Catecholamines 42-55 corticotropin releasing hormone Rattus norvegicus 0-30 7678287-1 1993 In vivo microdialysis was used to measure changes in extracellular concentrations of catecholamines and indoleamines in freely moving rats in response to administration of corticotropin-releasing factor (CRF). Catecholamines 85-99 corticotropin releasing hormone Rattus norvegicus 172-202 8462624-6 1993 These results indicate that in Bartter"s syndrome the vasoconstrictive effect of catecholamines and angiotensin II may be enhanced by concomitant NPY release. Catecholamines 81-95 neuropeptide Y Homo sapiens 146-149 8462624-7 1993 Whether a release of the vasodilator substance P is an independent mechanism or represents a reflex response to the increased secretion of angiotensin II, catecholamines and/or NPY remains to be established. Catecholamines 155-169 tachykinin precursor 1 Homo sapiens 37-48 8459190-0 1993 Growth hormone (GH) suppression of catecholamine turnover in the chicken hypothalamus: implications for GH autoregulation. Catecholamines 35-48 growth hormone Gallus gallus 0-14 8459190-0 1993 Growth hormone (GH) suppression of catecholamine turnover in the chicken hypothalamus: implications for GH autoregulation. Catecholamines 35-48 growth hormone Gallus gallus 16-18 8348337-1 1993 Aromatic L-amino acid decarboxylase (AADC) is involved in the biosynthesis of catecholamines and indolamines. Catecholamines 78-92 dopa decarboxylase Homo sapiens 37-41 8480508-6 1993 Increases in peripheral vascular resistance (PVR), caused by elevated levels of circulating catecholamines, appear to be the primary aetiology. Catecholamines 92-106 PVR cell adhesion molecule Homo sapiens 45-48 8055053-7 1993 On that base we suppose that variations of COMT and MAO activities can significantly change the catecholamines content in the blood vessels of reproductive organs of pigs. Catecholamines 96-110 catechol-O-methyltransferase Sus scrofa 43-47 8374808-10 1993 It is concluded from our studies that in general, catecholamine concentrations in various regions of the brain and spinal cord of sexually mature pigs parallel distributions of neuropeptides, substance P, and methionine enkephalin, as previously reported. Catecholamines 50-63 proenkephalin Sus scrofa 220-230 7834495-12 1993 In lactotroph cells Rab3b seems to play a stimulatory role, whereas Rab3a acts as a negative regulator of catecholamine release in chromaffin cells. Catecholamines 106-119 RAB3A, member RAS oncogene family Homo sapiens 68-73 8101456-6 1993 TGF-beta 1 substituted for CEE-derived factors and supported the in vitro differentiation of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) immunoreactivities, as well as catecholamine biosynthesis and storage. Catecholamines 186-199 transforming growth factor beta 1 Gallus gallus 0-10 8454456-2 1993 Activation of these multiple systems--as a result of renin, angiotensin II and the action of circulatory catecholamines--causes the release of norepinephrine vasopressin and aldosterone. Catecholamines 105-119 arginine vasopressin Homo sapiens 158-169 8432288-1 1993 Neuropeptide Y (NPY) is thought to be co-released with catecholamines in response to major cardiovascular stresses, but its relation to the release of catecholamines in response to minor stresses has been less well described. Catecholamines 55-69 neuropeptide Y Homo sapiens 0-14 8432288-1 1993 Neuropeptide Y (NPY) is thought to be co-released with catecholamines in response to major cardiovascular stresses, but its relation to the release of catecholamines in response to minor stresses has been less well described. Catecholamines 55-69 neuropeptide Y Homo sapiens 16-19 8432288-1 1993 Neuropeptide Y (NPY) is thought to be co-released with catecholamines in response to major cardiovascular stresses, but its relation to the release of catecholamines in response to minor stresses has been less well described. Catecholamines 151-165 neuropeptide Y Homo sapiens 0-14 8432288-1 1993 Neuropeptide Y (NPY) is thought to be co-released with catecholamines in response to major cardiovascular stresses, but its relation to the release of catecholamines in response to minor stresses has been less well described. Catecholamines 151-165 neuropeptide Y Homo sapiens 16-19 8432288-3 1993 In both normal and heart failure patients, NPY-Li-decreased (296 +/- 73 to 233 +/- 63 pg.ml-1 and 652 +/- 36 to 516 +/- 25 pg.ml-1 (P < 0.01) respectively) in response to standing, whereas catecholamines increased in both groups (norepinephrine 203 +/- 73 to 507 +/- 165 pg.ml-1 and 493 +/- 197 to 813 +/- 336 pg.ml-1 (P < 0.001) respectively and epinephrine 23 +/- 12 to 38 +/- 12 pg.ml-1 and 46 +/- 19 to 62 +/- 28 pg.ml-1 (P < 0.001) respectively). Catecholamines 192-206 neuropeptide Y Homo sapiens 43-46 8428704-6 1993 These results demonstrate that catecholamines are part of the factors which determine the tissue specificity of LPL regulation. Catecholamines 31-45 lipoprotein lipase Rattus norvegicus 112-115 8433522-3 1993 To switch of catecholamine phenotype in the nervous and endocrine systems, we generated a line of transgenic mice carrying a chimeric gene containing human phenylethanolamine N-methyltransferase (PNMT) cDNA fused to the 4-kb fragment of the human dopamine beta-hydroxylase (DBH) gene promoter. Catecholamines 13-26 phenylethanolamine N-methyltransferase Homo sapiens 196-200 8093477-3 1993 This study examined the distribution of fibers, terminals, and cell bodies that are immunoreactive for tyrosine hydroxylase (TH) (the rate-limiting enzyme in the synthesis of catecholamines) in song-control nuclei of adult males and females and juvenile males. Catecholamines 175-189 tyrosine hydroxylase Homo sapiens 103-123 8093477-3 1993 This study examined the distribution of fibers, terminals, and cell bodies that are immunoreactive for tyrosine hydroxylase (TH) (the rate-limiting enzyme in the synthesis of catecholamines) in song-control nuclei of adult males and females and juvenile males. Catecholamines 175-189 tyrosine hydroxylase Homo sapiens 125-127 8100277-13 1993 Catecholamines induce GH release in most animal species by stimulating GHRH neurones and inhibiting somatostatin-releasing neurones. Catecholamines 0-14 gonadotropin releasing hormone receptor Rattus norvegicus 22-24 8100277-13 1993 Catecholamines induce GH release in most animal species by stimulating GHRH neurones and inhibiting somatostatin-releasing neurones. Catecholamines 0-14 growth hormone releasing hormone Rattus norvegicus 71-75 8100277-13 1993 Catecholamines induce GH release in most animal species by stimulating GHRH neurones and inhibiting somatostatin-releasing neurones. Catecholamines 0-14 somatostatin Rattus norvegicus 100-112 8389998-1 1993 The controversy about putative stimulatory and inhibitory functions of catecholamines in regulation of ACTH secretion has been recently shifted towards a consensus that during stress catecholamines stimulate corticotropin-releasing factor (CRF-41) containing neurons through alpha 1-adrenoreceptors, while inhibiting their own secretion acting on presynaptic alpha 2-receptors. Catecholamines 183-197 corticotropin releasing hormone Rattus norvegicus 208-238 8417001-8 1993 MAO inhibitors eliminated the biochemical indications of increased H2O2 production and increased the catecholamine concentrations. Catecholamines 101-114 monoamine oxidase A Rattus norvegicus 0-3 8369108-3 1993 Therefore inhibition of enzymes, like the extraneuronal and neuronal located MAO or the predominantly glial situated COMT, which both metabolize catecholamines, may induce an increased biosynthesis of neurotrophic factors. Catecholamines 145-159 catechol-O-methyltransferase Homo sapiens 117-121 8369108-6 1993 But on the other hand in vivo and in vitro studies show, that COMT-inhibitors may intensify the metabolisation of catecholamines in neurones by MAO, what may cause an enhanced generation of free radicals. Catecholamines 114-128 catechol-O-methyltransferase Homo sapiens 62-66 8321376-0 1993 Acute effect of erythropoietin on catecholamine levels in uremia. Catecholamines 34-47 erythropoietin Homo sapiens 16-30 1363170-9 1992 In contrast, cultures containing numerous neurons immunoreactive for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, could be successfully established from medulla oblongata of any age between E13 and E16. Catecholamines 124-137 tyrosine hydroxylase Rattus norvegicus 69-89 8419906-4 1993 Since alpha 2-adrenoceptor stimulation suppresses insulin secretion, catecholamines from intrapancreatic nerve terminals may be involved in the mechanism behind the marked impairment of the glucose-stimulated insulin response in the intact pancreas. Catecholamines 69-83 insulin Homo sapiens 209-216 1335253-2 1992 In the present study, we examined the relationship between phospholipase A2 and C activation and catecholamine secretion by PGE2 in chromaffin cells. Catecholamines 97-110 LOC104974671 Bos taurus 59-75 1335253-3 1992 The phospholipase A2 inhibitors p-bromophenacyl bromide and mepacrine did not affect the basal and ouabain-induced release, but dose-dependently blocked PGE2-evoked phosphoinositide metabolism and the consequent catecholamine release at an IC50 value of 3 microM. Catecholamines 212-225 LOC104974671 Bos taurus 4-20 1465439-1 1992 Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons. Catecholamines 111-124 dopa decarboxylase Rattus norvegicus 0-35 1465439-1 1992 Aromatic L-amino acid decarboxylase (AADC, EC 4.1.1.28) catalyzes the decarboxylation of L-dopa to dopamine in catecholamine cells and 5-hydroxytryptophan to serotonin in serotonin-producing neurons. Catecholamines 111-124 dopa decarboxylase Rattus norvegicus 37-41 1290617-4 1992 The losartan-sensitive sites have been shown to mediate all of the major ANG II-induced biologic effects, including vasoconstriction, aldosterone and catecholamine release, and central, ANG II-induced drinking behavior. Catecholamines 150-163 angiotensinogen Homo sapiens 73-79 1334970-0 1992 Lipolytic catecholamine resistance due to decreased beta 2-adrenoceptor expression in fat cells. Catecholamines 10-23 adrenoceptor beta 2 Homo sapiens 52-71 1359019-11 1992 That in situ DA synthesis rates are elevated consequent to the rise in TH levels demonstrates that TH induction serves as a mechanism for enhancing the catecholamine-synthesizing capacity of the chromaffin cell on a long-term basis. Catecholamines 152-165 tyrosine hydroxylase Bos taurus 99-101 1481892-10 1992 These data suggest that responses to PACAP and VIP are mediated by distinct receptors and that pressor responses to PACAP are due to the release of catecholamines from the adrenal gland. Catecholamines 148-162 adenylate cyclase activating polypeptide 1 Homo sapiens 116-121 1336886-9 1992 This data supports the known effects of CPR on catecholamine release. Catecholamines 47-60 cytochrome p450 oxidoreductase Homo sapiens 40-43 1431906-0 1992 Regulation of carboxypeptidase E by membrane depolarization in PC12 pheochromocytoma cells: comparison with mRNAs encoding other peptide- and catecholamine-biosynthetic enzymes. Catecholamines 142-155 carboxypeptidase E Rattus norvegicus 14-32 1283213-5 1992 Our results indicate that 41% of all carotid body afferent neurons express tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, whereas 7% contain substance P. Tyrosine hydroxylase- and substance P-positive neurons constitute separate subpopulations of carotid body afferents, as these two phenotypes were not colocalized. Catecholamines 125-138 tyrosine hydroxylase Rattus norvegicus 75-95 1304621-5 1992 These data indicate the possibility that peripherally administered R-THBP increases the biosynthesis of catecholamine especially in the daytime. Catecholamines 104-117 prolyl 4-hydroxylase, beta polypeptide Mus musculus 69-73 1331087-1 1992 Catecholamines stimulate proopiomelanocortin (POMC) gene expression in corticotrope cells, but the molecular mechanisms of these effects are not known. Catecholamines 0-14 pro-opiomelanocortin-alpha Mus musculus 25-44 1331087-1 1992 Catecholamines stimulate proopiomelanocortin (POMC) gene expression in corticotrope cells, but the molecular mechanisms of these effects are not known. Catecholamines 0-14 pro-opiomelanocortin-alpha Mus musculus 46-50 1422854-2 1992 Central administration of the stress hormone corticotropin releasing factor (CRF) has been shown to affect a variety of behaviors and also to potently increase the release of central catecholamines. Catecholamines 183-197 corticotropin releasing hormone Rattus norvegicus 45-75 1445888-1 1992 Aromatic-L-amino-acid decarboxylase (AADC) is an enzyme that plays an essential role in synthesizing catecholamines and serotonin in neuronal and endocrine tissues. Catecholamines 101-115 dopa decarboxylase Homo sapiens 0-35 1445888-1 1992 Aromatic-L-amino-acid decarboxylase (AADC) is an enzyme that plays an essential role in synthesizing catecholamines and serotonin in neuronal and endocrine tissues. Catecholamines 101-115 dopa decarboxylase Homo sapiens 37-41 1298554-7 1992 Moreover, the plasma NPY increase which has been observed in preclinic heart failure when plasma catecholamine levels is usually not significantly different from normal values, may be a useful and reliable prognostic marker. Catecholamines 97-110 neuropeptide Y Homo sapiens 21-24 1474052-5 1992 On the other hand, insulin-induced hypoglycemia during HDT produced increases in ADH, cortisol, PRA, aldosterone, and catecholamine levels. Catecholamines 118-131 insulin Homo sapiens 19-26 1289063-4 1992 When assayed on cultured rat sympathetic neurons, the major activities in footpad extracts from postnatal day 21 rat pups that induce choline acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP) and reduce catecholamines and neuropeptide Y (NPY) are associated with a soluble protein of 22-26 x 10(3) M(r) and a pI of 5.0. Catecholamines 218-232 vasoactive intestinal peptide Rattus norvegicus 202-205 1402916-11 1992 The experiments suggest that: (1) scinderin is an intracellular target for Ca2+, (2) permeabilization of chromaffin cells with digitonin in the presence of micromolar Ca2+ concentrations retained Ca(2+)-binding proteins including scinderin, and (3) the retention of these proteins may be related to the increase in the subsequent Ca(2+)-dependent catecholamine release observed in permeabilized chromaffin cells. Catecholamines 347-360 scinderin Homo sapiens 34-43 1281529-6 1992 The present data suggest that arcuate nucleus GABA and catecholamine fibers may influence luteinizing hormone-releasing hormone-containing neurons via projective pro-opiomelanocortin cells. Catecholamines 55-68 proopiomelanocortin Rattus norvegicus 162-182 1335129-8 1992 Furthermore, catecholamines and ATP, which are released under various pathophysiological conditions often associated with intracellular acidosis, could play an important role in the modulation of pHi under these conditions. Catecholamines 13-27 glucose-6-phosphate isomerase Rattus norvegicus 196-199 1461360-10 1992 Thus, these catecholamine neurotransmitters are envisaged to comprise an intermediary step in the functional role played by NPY in the hypothalamus in integrating the control of energy metabolism and caloric intake. Catecholamines 12-25 neuropeptide Y Rattus norvegicus 124-127 1335135-3 1992 In PTX-treated cells catecholamine secretion evoked by VIP occurs with minimal elevation of cyclic AMP and is only slightly enhanced by cyclic nucleotide phosphodiesterase inhibitors. Catecholamines 21-34 vasoactive intestinal peptide Bos taurus 55-58 1359396-3 1992 When beta 1 receptors were blocked with 10 microM CGP 20712A, catecholamines still maximally activated cAMP accumulation, with only small decreases in potency. Catecholamines 62-76 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 5-11 1445298-0 1992 Regulation of human cardiac myosin heavy chain genes: the effect of catecholamine. Catecholamines 68-81 myosin heavy chain 6 Homo sapiens 28-46 1488103-1 1992 Catecholamines have been shown to activate hypothalamic corticotropin-releasing factor-41 (CRF) synthesis and release. Catecholamines 0-14 corticotropin releasing hormone Homo sapiens 56-89 1439397-12 1992 But modulators such as growth hormone and catecholamines may also potentiate the effect of hypoxia per se on erythropoietin production. Catecholamines 42-56 erythropoietin Homo sapiens 109-123 1475022-4 1992 The frequency of the contralateral rotation, induced by intra-ventral pallidal injection of DADL (which closely mimics the endogenous enkephalin peptides, exhibiting a high affinity for the delta receptor with a moderate affinity for mu receptors), increased with intraperitoneal pretreatment with amphetamine, suggesting that enhanced release of catecholamines potentiated effects of opioids in the ventral pallidum. Catecholamines 347-361 proenkephalin Rattus norvegicus 134-144 1445298-8 1992 These findings suggest that catecholamine does activate the human cardiac MyHC genes but does not differentiate the specific expression of either the alpha- or beta-MyHC genes. Catecholamines 28-41 myosin heavy chain 6 Homo sapiens 74-78 1445172-3 1992 On the other hand, phaeochromocytoma and hyperaldosteronism, via the respective actions of catecholamines and hypokalaemia on the pancreatic beta-cell, impair glucose tolerance primarily by inhibiting insulin release. Catecholamines 91-105 insulin Homo sapiens 201-208 1329466-6 1992 Angiotensin-converting enzyme (ACE) inhibitors can modulate circulating catecholamines, and the persistence and degree of ACE inhibition may be important not only in reducing catecholamines, but possibly also in reducing mortality in heart failure. Catecholamines 72-86 angiotensin I converting enzyme Homo sapiens 0-29 1329466-6 1992 Angiotensin-converting enzyme (ACE) inhibitors can modulate circulating catecholamines, and the persistence and degree of ACE inhibition may be important not only in reducing catecholamines, but possibly also in reducing mortality in heart failure. Catecholamines 72-86 angiotensin I converting enzyme Homo sapiens 31-34 1329466-6 1992 Angiotensin-converting enzyme (ACE) inhibitors can modulate circulating catecholamines, and the persistence and degree of ACE inhibition may be important not only in reducing catecholamines, but possibly also in reducing mortality in heart failure. Catecholamines 175-189 angiotensin I converting enzyme Homo sapiens 0-29 1329466-6 1992 Angiotensin-converting enzyme (ACE) inhibitors can modulate circulating catecholamines, and the persistence and degree of ACE inhibition may be important not only in reducing catecholamines, but possibly also in reducing mortality in heart failure. Catecholamines 175-189 angiotensin I converting enzyme Homo sapiens 31-34 1329466-6 1992 Angiotensin-converting enzyme (ACE) inhibitors can modulate circulating catecholamines, and the persistence and degree of ACE inhibition may be important not only in reducing catecholamines, but possibly also in reducing mortality in heart failure. Catecholamines 175-189 angiotensin I converting enzyme Homo sapiens 122-125 1331675-1 1992 We investigated the effect of catecholamine depletion on gene expression for preproenkephalin A (PPA) and D2 dopamine receptor (D2R) in the rat nigrostriatal complex, using quantitative Northern blot analysis. Catecholamines 30-43 dopamine receptor D2 Rattus norvegicus 106-126 1417915-0 1992 Catecholamines are required for testosterone induction of ornithine decarboxylase in the mouse kidney. Catecholamines 0-14 ornithine decarboxylase, structural 1 Mus musculus 58-81 1331675-1 1992 We investigated the effect of catecholamine depletion on gene expression for preproenkephalin A (PPA) and D2 dopamine receptor (D2R) in the rat nigrostriatal complex, using quantitative Northern blot analysis. Catecholamines 30-43 dopamine receptor D2 Rattus norvegicus 128-131 1336061-10 1992 It is suggested that this up-regulation of the beta 2-adrenoceptor subtype could be owing to an increased importance of circulating catecholamines in modulating positive chronotropic and inotropic effects. Catecholamines 132-146 adrenoceptor beta 2 Homo sapiens 47-66 1331754-4 1992 The endogenous catecholamines epinephrine (EPI) and norepinephrine (NE) were found to have low affinities (micromolar) for the beta 3AR of both species. Catecholamines 15-29 adrenoceptor beta 3 Homo sapiens 127-135 1395110-0 1992 Enhancement by endothelin-1 of the release of catecholamines from the canine adrenal gland in response to splanchnic nerve stimulation. Catecholamines 46-60 endothelin 1 Canis lupus familiaris 15-27 1395110-2 1992 The effect of endothelin-1 on the release of adrenal catecholamines was examined in anaesthetized dogs. Catecholamines 53-67 endothelin 1 Canis lupus familiaris 14-26 1395110-6 1992 Endothelin-1 (0.1 and 0.3 micrograms/kg) significantly enhanced the release of adrenal catecholamines induced by 3 Hz SNS, but did not affect basal release and the release of adrenal catecholamines induced by 1 Hz SNS. Catecholamines 87-101 endothelin 1 Canis lupus familiaris 0-12 1395110-10 1992 These results indicate that endothelin-1 enhances the release of adrenal catecholamines from the canine adrenal gland in response to relatively high frequency SNS. Catecholamines 73-87 endothelin 1 Canis lupus familiaris 28-40 1505449-4 1992 In addition, CRH produced a greater elevation of plasma levels of catecholamines and NPY, which persisted for a longer period of time in the aged rats compared to responses in the young animals. Catecholamines 66-80 corticotropin releasing hormone Rattus norvegicus 13-16 1300039-0 1992 Effects of neuropeptide Y injected into A1 noradrenergic nucleus on blood pressure and catecholamines in plasma of cats. Catecholamines 87-101 neuropeptide Y Felis catus 11-25 1358455-6 1992 Immunohistochemistry performed on either fetal (day 19) or newborn (less than 15h after birth) ovaries showed the presence of catecholaminergic nerves, identified by their content of immunoreactive tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 126-139 tyrosine hydroxylase Rattus norvegicus 198-218 1358455-6 1992 Immunohistochemistry performed on either fetal (day 19) or newborn (less than 15h after birth) ovaries showed the presence of catecholaminergic nerves, identified by their content of immunoreactive tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 126-139 tyrosine hydroxylase Rattus norvegicus 220-222 1356768-4 1992 Combining visible spectroscopy and equilibrium-binding studies, it was found that catecholamines bind to hTH1 and hTH2 with a stoichiometry of about 1.0 mol/mol enzyme subunit, interacting with the catalytic iron at the active site. Catecholamines 82-96 negative elongation factor complex member C/D Homo sapiens 105-109 1438987-6 1992 These findings suggest that the atrial natriuretic factor may alter catecholamine secretion by modifying the calcium available for the exocytotic process of catecholamine output. Catecholamines 68-81 natriuretic peptide A Rattus norvegicus 32-57 1438987-6 1992 These findings suggest that the atrial natriuretic factor may alter catecholamine secretion by modifying the calcium available for the exocytotic process of catecholamine output. Catecholamines 157-170 natriuretic peptide A Rattus norvegicus 32-57 1356594-8 1992 Immunohistochemical staining with antibodies against catecholamine synthesizing enzymes tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) showed that surgical reconstruction treated cat cords but not transection-only, developed dense bundles of dopaminergic and noradrenergic fibers which were present in the collagen matrix bridge and in the distal spinal cord. Catecholamines 53-66 dopamine beta-hydroxylase Felis catus 145-148 1356595-6 1992 In addition, the content of either of the opioids enkephalin or dynorphin appears to distinguish subsets of medullary catecholamine neurons. Catecholamines 118-131 proenkephalin Rattus norvegicus 50-60 1337228-3 1992 Within 1-2 hrs after administration of dihydroxyphenylalanine the excessive secretion of catecholamines altered adrenoreceptor system sensitivity in Langerhans islands with the subsequent decrease in insulin production. Catecholamines 89-103 insulin Canis lupus familiaris 200-207 1327833-4 1992 These results suggest that beta 2-adrenoceptor-mediated electrical cardiac responses to endogenous catecholamines also exist in addition to the predominant beta 1-adrenoceptor-mediated responses, and that the order of the proportion of beta 2-adrenoceptor-mediated cardiac effects was SA node pacemaker activity much greater than AV conductivity = atrial ERP much greater than ventricular ERP in the dog heart. Catecholamines 99-113 beta-2 adrenergic receptor Canis lupus familiaris 27-46 1327833-4 1992 These results suggest that beta 2-adrenoceptor-mediated electrical cardiac responses to endogenous catecholamines also exist in addition to the predominant beta 1-adrenoceptor-mediated responses, and that the order of the proportion of beta 2-adrenoceptor-mediated cardiac effects was SA node pacemaker activity much greater than AV conductivity = atrial ERP much greater than ventricular ERP in the dog heart. Catecholamines 99-113 beta-2 adrenergic receptor Canis lupus familiaris 236-255 1327836-5 1992 In the present study, we examined the possible involvement of hypothalamic catecholamines in the effect of IL-1 beta on hypothalamic CRF secretion, by using an in vitro rat hypothalami continuous perifusion system. Catecholamines 75-89 interleukin 1 beta Rattus norvegicus 107-116 1417915-2 1992 We have found that the existing levels of renal ODC in male mice and the increase induced by testosterone in male, female, castrated male and hypophysectomized mice were dramatically impaired by catecholamine depletion produced by treatment with either alpha-methyl-p-tyrosine or reserpine. Catecholamines 195-208 ornithine decarboxylase, structural 1 Mus musculus 48-51 1417915-5 1992 All these findings demonstrate that catecholamines and alpha 1-adrenergic receptors are implicated in androgen-regulated ODC activity in the mouse kidney and suggest a plausible role of sympathetic renal innervation in enzyme induction by steroid hormones in this organ. Catecholamines 36-50 ornithine decarboxylase, structural 1 Mus musculus 121-124 1459656-2 1992 The relative rate of different routes of disposition of catecholamines was in the following order: for (-)-NE COMT greater than or equal to MAO greater than or equal to U2 greater than U1, for (-)-Epi U2 greater than or equal to COMT greater than MAO greater than U1. Catecholamines 56-70 catechol-O-methyltransferase Gallus gallus 110-114 1423500-5 1992 During the active phase of cholinergically stimulated catecholamine secretion, the amount of synexin label was reduced by 33% in the nucleus, by 23% in the cytosol, and by 51% in the granule area. Catecholamines 54-67 annexin A7 Bos taurus 93-100 1353443-16 1992 Thus, it appears that after cholinergic stimulation, PC12 dynorphin is cosecreted with catecholamines, a phenomenon described for a number of neuropeptides, including the proenkephalin-derived opioids. Catecholamines 87-101 proenkephalin Rattus norvegicus 171-184 1357020-3 1992 To determine if the increase in TH protein content in the carotid body could alter catecholamine biosynthesis, in vitro TH activity and catecholamine turnover were measured in rats submitted to hypoxia for 14 days. Catecholamines 83-96 tyrosine hydroxylase Rattus norvegicus 32-34 1459656-2 1992 The relative rate of different routes of disposition of catecholamines was in the following order: for (-)-NE COMT greater than or equal to MAO greater than or equal to U2 greater than U1, for (-)-Epi U2 greater than or equal to COMT greater than MAO greater than U1. Catecholamines 56-70 catechol-O-methyltransferase Gallus gallus 229-233 1353301-9 1992 These results indicate that the inhibitory effects exerted by the sympathetic nervous system on insulin secretion are mediated not only by the classical neurotransmitter norepinephrine acting on alpha 2-adrenoceptors but also by a nonadrenergic cotransmitter that can maintain transmission under conditions of catecholamine deficiency. Catecholamines 310-323 insulin Canis lupus familiaris 96-103 1497634-0 1992 Calmodulin is involved in catecholamine secretion from digitonin-permeabilized bovine adrenal medullary chromaffin cells. Catecholamines 26-39 calmodulin Bos taurus 0-10 1511343-7 1992 Overall, catecholamine concentrations within the OB, but not the hypothalamus, were significantly greater in C57/Bl compared to CD-1 mice. Catecholamines 9-22 Casitas B-lineage lymphoma Mus musculus 109-115 1511343-7 1992 Overall, catecholamine concentrations within the OB, but not the hypothalamus, were significantly greater in C57/Bl compared to CD-1 mice. Catecholamines 9-22 CD1 antigen complex Mus musculus 128-132 1488334-2 1992 It was found, that captopril in hypertensive patients with high plasma renin activity decreases both systolic and diastolic blood pressure, decelerates heart rate, and decreases serum total catecholamines and plasma renin activity. Catecholamines 190-204 renin Homo sapiens 71-76 1639176-0 1992 Catecholamine metabolism in the vas deferens and the adrenal gland with special reference to the central catecholamine-depleted state. Catecholamines 0-13 arginine vasopressin Rattus norvegicus 32-35 1639176-1 1992 Experiments were carried out to elucidate the role of central catecholamines in regulating catecholamine metabolism in the vas deferens and adrenal gland of the rat. Catecholamines 62-76 arginine vasopressin Rattus norvegicus 123-126 1639176-1 1992 Experiments were carried out to elucidate the role of central catecholamines in regulating catecholamine metabolism in the vas deferens and adrenal gland of the rat. Catecholamines 62-75 arginine vasopressin Rattus norvegicus 123-126 1495171-6 1992 These results suggest that Ca2+ antagonist such as nicardipine directly inhibits the catecholamine releases from the adrenal glands. Catecholamines 85-98 carbonic anhydrase 2 Canis lupus familiaris 27-30 1384463-6 1992 All catecholamines that were administered stimulated the activity of myocardial G-6-PD in a time- and dose-dependent manner. Catecholamines 4-18 glucose-6-phosphate dehydrogenase Rattus norvegicus 80-86 1504752-11 1992 Binding of [3H]-GR65630 and [3H]-LY278584 to the terminal region of the small intestine was inhibited by 5-HT3 receptor ligands ondansetron and S-zacopride (and 5-hydroxytryptamine), but not by 5-HT1, 5-HT2, catecholamine, gamma-aminobutyric acid and opioid receptor ligands. Catecholamines 208-221 5-hydroxytryptamine receptor 3A Rattus norvegicus 105-119 1473654-8 1992 CONCLUSIONS: The relationship between the renin angiotensin system and catecholamines is complex but our findings indicate that: 1) Traditional therapy is effective in improving symptoms, but cannot induce a decrease of vasoconstrictive neurohormones; 2) ACE inhibitor therapy reduces ANF and neurohormonal activation. Catecholamines 71-85 renin Homo sapiens 42-47 1352511-6 1992 In addition, the pressor response to exogenously administered ANG I and ANG II was attenuated by alpha adrenergic receptor blockade and thus may be due, in part, to secondary catecholamine release. Catecholamines 175-188 angiogenin-4 Alligator mississippiensis 62-65 1352511-6 1992 In addition, the pressor response to exogenously administered ANG I and ANG II was attenuated by alpha adrenergic receptor blockade and thus may be due, in part, to secondary catecholamine release. Catecholamines 175-188 angiogenin-4 Alligator mississippiensis 72-75 1320047-9 1992 It is concluded that an increased lipolytic sensitivity for beta 1- and beta 2-agonists can be due to an increase in the amount of the two adrenoceptor subtypes in omental fat cells and thereby explain why catecholamines are more lipolytic in omental cells than in sc fat cells. Catecholamines 206-220 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 60-78 1618356-5 1992 Stress hormones such as catecholamines (adrenalin, nonadrenaline and dopamine) and the hypothalamic-pituitary-adrenal axis interact with hormones which are responsible for normal ovulatory cycles: i.e., gonadotropin releasing hormone (GnRH), prolactin, LH and FSH. Catecholamines 24-38 gonadotropin releasing hormone 1 Homo sapiens 203-233 1352985-1 1992 Transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated in a tissue-specific manner. Catecholamines 72-85 tyrosine hydroxylase Rattus norvegicus 17-37 1352985-1 1992 Transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated in a tissue-specific manner. Catecholamines 72-85 tyrosine hydroxylase Rattus norvegicus 39-41 1509494-4 1992 The observation of high blood pressure and elevated levels of renin suggests that in addition to increased circulating catecholamines following scorpion envenomation, sympathetically induced renin release may play an important role in the pathogenesis of hypertension. Catecholamines 119-133 renin Homo sapiens 62-67 1627126-0 1992 Inhibition of Ca(2+)-dependent catecholamine release by myosin light chain kinase inhibitor, wortmannin, in adrenal chromaffin cells. Catecholamines 31-44 myosin light chain kinase, smooth muscle Bos taurus 56-81 1352466-1 1992 Catecholamine-induced lipolysis is chiefly mediated through the recently characterized beta 3-adrenergic receptor (AR) in rat adipocytes. Catecholamines 0-13 adrenoceptor beta 3 Rattus norvegicus 87-113 1524767-8 1992 The DuP 753-sensitive site (AT1 receptor) mediates all the major Ang II-induced biological effects, including adrenal aldosterone and catecholamine secretion, release of catecholamines from sympathetic ganglia, central nervous system responses, and vasoconstriction. Catecholamines 134-147 angiotensin II receptor type 1 Homo sapiens 28-31 1331222-13 1992 Circulating catecholamine levels were reduced by central ACE inhibition. Catecholamines 12-25 angiotensin I converting enzyme Rattus norvegicus 57-60 1524767-8 1992 The DuP 753-sensitive site (AT1 receptor) mediates all the major Ang II-induced biological effects, including adrenal aldosterone and catecholamine secretion, release of catecholamines from sympathetic ganglia, central nervous system responses, and vasoconstriction. Catecholamines 170-184 angiotensin II receptor type 1 Homo sapiens 28-31 1353855-10 1992 Our data suggest that the previously reported diminution in catecholamines associated with exercise may be due to a decrease in TH mRNA and a resulting decrease in TH activity. Catecholamines 60-74 tyrosine hydroxylase Rattus norvegicus 128-130 1353855-10 1992 Our data suggest that the previously reported diminution in catecholamines associated with exercise may be due to a decrease in TH mRNA and a resulting decrease in TH activity. Catecholamines 60-74 tyrosine hydroxylase Rattus norvegicus 164-166 1629106-6 1992 The catecholamine- (epinephrine plus norepinephrine) to-insulin molar ratio was correlated with Ra during the early period (r = 0.52, P less than 0.01) and over the entire period of exercise (r = 0.66, P less than 0.0001). Catecholamines 4-17 insulin Canis lupus familiaris 56-63 1504370-5 1992 This suggests that catecholamines mediate shock-induced suppression of interferon-gamma production. Catecholamines 19-33 interferon gamma Rattus norvegicus 71-87 1303174-1 1992 We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine. Catecholamines 141-154 phenylethanolamine N-methyltransferase Homo sapiens 67-105 1303174-1 1992 We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine. Catecholamines 141-154 phenylethanolamine N-methyltransferase Homo sapiens 107-111 1629106-8 1992 We hypothesize that the catecholamine-to-insulin molar ratio is important during the early period of exercise and possibly during late exercise as an additional regulatory factor to the glucagon-to-insulin molar ratio. Catecholamines 24-37 insulin Canis lupus familiaris 41-48 1629106-8 1992 We hypothesize that the catecholamine-to-insulin molar ratio is important during the early period of exercise and possibly during late exercise as an additional regulatory factor to the glucagon-to-insulin molar ratio. Catecholamines 24-37 insulin Canis lupus familiaris 198-205 1629521-3 1992 Plasma levels of catecholamine (CA) were elevated in both groups II and III, particularly in NA: average value at 33 h after the exposure of CCl4 increased to 290-fold of the control in group II and to 513-fold in group III. Catecholamines 17-30 C-C motif chemokine ligand 4 Rattus norvegicus 141-145 1383560-1 1992 We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. Catecholamines 188-201 tyrosine hydroxylase Rattus norvegicus 143-163 1349344-3 1992 In this study the effects of a single and repeated immobilization stress on mRNA levels of the adrenal catecholamine biosynthetic enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase, were examined. Catecholamines 103-116 tyrosine hydroxylase Rattus norvegicus 139-159 1349344-3 1992 In this study the effects of a single and repeated immobilization stress on mRNA levels of the adrenal catecholamine biosynthetic enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase, were examined. Catecholamines 103-116 dopamine beta-hydroxylase Rattus norvegicus 164-189 1353501-1 1992 Catecholamines produce a number of biochemical changes most of which result from stimulation of beta 2-receptors. Catecholamines 0-14 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 96-102 1383560-1 1992 We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. Catecholamines 188-201 tyrosine hydroxylase Rattus norvegicus 165-167 1424336-2 1992 Administration of digitalis, catecholamine and angiotensin converting enzyme inhibitor resulted in decrease of ANP levels as well as improvement of clinical symptoms of CHF and cardiomegaly. Catecholamines 29-42 natriuretic peptide A Homo sapiens 111-114 1602402-1 1992 Administration of either endotoxin (lipopolysaccharide, LPS) or interleukin-1 (IL-1) activates the hypothalamic-pituitary-adrenal axis and cerebral catecholamine systems. Catecholamines 148-161 interleukin 1 complex Mus musculus 64-83 1377728-7 1992 An immunohistochemical examination using the avidin-biotin procedure revealed that many SRF cells (estimated 57% of all SRF cells) were immunoreactive for tyrosine hydroxylase (TH, a marker of catecholamine cells). Catecholamines 193-206 tyrosine hydroxylase Homo sapiens 177-179 1334871-0 1992 [Changes in the catecholamine level in a dialysate of the striatum with the chronic administration into it of an enkephalin-like tetrapeptide causing catalepsy in rats]. Catecholamines 16-29 proenkephalin Rattus norvegicus 113-123 1320721-1 1992 Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis. Catecholamines 135-148 phenylethanolamine-N-methyltransferase Mus musculus 0-38 1320721-1 1992 Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis. Catecholamines 135-148 phenylethanolamine-N-methyltransferase Mus musculus 40-44 1604044-2 1992 Some anesthetic agents are known to modify plasma levels of catecholamines; moreover NPY is co-released with noradrenaline or adrenaline under certain conditions. Catecholamines 60-74 neuropeptide Y Rattus norvegicus 85-88 1332098-2 1992 Because (1) acute LiCl administration increases sympathoadrenal function, and in turn plasma glucose levels, and (2) stimulation of either the 5-HT1A, the 5-HT1C or the 5-HT2 receptor subtype has adrenal catecholamine-releasing and hyperglycemic effects, we have investigated the influence of prior blockade of either of these receptor subtypes on plasma catecholamine and glucose responses to acute LiCl administration in conscious, catheterized rats. Catecholamines 204-217 5-hydroxytryptamine receptor 1A Rattus norvegicus 143-149 1332098-2 1992 Because (1) acute LiCl administration increases sympathoadrenal function, and in turn plasma glucose levels, and (2) stimulation of either the 5-HT1A, the 5-HT1C or the 5-HT2 receptor subtype has adrenal catecholamine-releasing and hyperglycemic effects, we have investigated the influence of prior blockade of either of these receptor subtypes on plasma catecholamine and glucose responses to acute LiCl administration in conscious, catheterized rats. Catecholamines 204-217 5-hydroxytryptamine receptor 2C Rattus norvegicus 155-161 1619214-6 1992 The decrease in concentration of inner medullary catecholamines in the early postnatal period is consistent with the reported total loss of tyrosine hydroxylase- and dopamine beta hydroxylase-immunoreactive inner medullary nerve terminals at approximately 12 weeks of age. Catecholamines 49-63 dopamine beta-hydroxylase Felis catus 166-191 1613427-0 1992 Vasoactive intestinal peptide stimulation of aldosterone secretion by the rat adrenal cortex may be mediated by the local release of catecholamines. Catecholamines 133-147 vasoactive intestinal peptide Rattus norvegicus 0-29 1349644-5 1992 These data indicate that both receptor subtypes can stimulate the same adenylyl cyclase in membranes of control cells, and that the activation of adenylyl cyclase by beta 1 receptors by low concentrations of catecholamines can obscure the activation by beta 3 receptors by high concentrations of catecholamines. Catecholamines 208-222 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 166-172 1349644-5 1992 These data indicate that both receptor subtypes can stimulate the same adenylyl cyclase in membranes of control cells, and that the activation of adenylyl cyclase by beta 1 receptors by low concentrations of catecholamines can obscure the activation by beta 3 receptors by high concentrations of catecholamines. Catecholamines 296-310 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 166-172 1566932-0 1992 Evidence against a humoral control mechanism in adrenal catecholamine secretion during insulin-induced hypoglycemia. Catecholamines 56-69 insulin Canis lupus familiaris 87-94 1566932-1 1992 The present study tested the hypothesis that a humoral control mechanism is involved in the enhanced adrenal catecholamine secretion during insulin-induced hypoglycemia. Catecholamines 109-122 insulin Canis lupus familiaris 140-147 1566932-4 1992 Catecholamine output in the right innervated gland increased dose dependently (P less than 0.05), reaching a maximum level 45 min after insulin administration. Catecholamines 0-13 insulin Canis lupus familiaris 136-143 1317492-10 1992 We conclude that enkephalin biosynthesis, like co-stored catecholamines, is induced by a transsynaptic process. Catecholamines 57-71 proenkephalin Rattus norvegicus 17-27 1312445-3 1992 In this study we examined the effect of ACTH, potassium, (Bu)2cAMP (dbcAMP), and catecholamines on the adrenal renin-angiotensin system. Catecholamines 81-95 renin Bos taurus 111-116 1324051-2 1992 Bradykinin can release neuronal calcitonin gene-related peptide (CGRP) and adrenal medullary catecholamines, both of which could contribute to its cardiovascular effects in vivo. Catecholamines 93-107 kininogen 1 Homo sapiens 0-10 1324051-20 1992 The results indicate that the increase in hindquarters blood flow following administration of bradykinin in vivo is largely due to activation of beta 2-adrenoceptors by catecholamines released subsequent to direct stimulation of the adrenal medulla by the peptide. Catecholamines 169-183 kininogen 1 Homo sapiens 94-104 1312445-9 1992 Catecholamines had a weak stimulating effect on aldosterone secretion and were potent stimulators of adrenal renin activity in cells and medium. Catecholamines 0-14 renin Bos taurus 109-114 1572656-1 1992 Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a physiologically important enzyme in the metabolism of catecholamine neurotransmitters and catechol drugs. Catecholamines 107-120 catechol-O-methyltransferase Homo sapiens 0-28 1572656-1 1992 Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a physiologically important enzyme in the metabolism of catecholamine neurotransmitters and catechol drugs. Catecholamines 107-120 catechol-O-methyltransferase Homo sapiens 30-34 1325637-1 1992 Neuropeptide Y (NPY), first isolated in 1982, is widely distributed among the neurons of the central and peripheral nervous systems, often in close association with catecholamines. Catecholamines 165-179 neuropeptide Y Rattus norvegicus 0-14 1347783-1 1992 The activity (Vmax) of tyrosine hydroxylase (TH; EC 1.14.16.2), the rate limiting enzyme in the synthesis of catecholamines, is increased in carotid body, superior cervical ganglion, and the adrenal medulla during hypoxia (i.e., reduced PaO2). Catecholamines 109-123 tyrosine hydroxylase Rattus norvegicus 23-43 1347783-1 1992 The activity (Vmax) of tyrosine hydroxylase (TH; EC 1.14.16.2), the rate limiting enzyme in the synthesis of catecholamines, is increased in carotid body, superior cervical ganglion, and the adrenal medulla during hypoxia (i.e., reduced PaO2). Catecholamines 109-123 tyrosine hydroxylase Rattus norvegicus 45-47 1350074-6 1992 The extraneuronal enzyme, catechol-O-methyl transferase (COMT), inactivates catecholamines by O-methylation, and its inhibition leads to increased levels of striatal DA. Catecholamines 76-90 catechol-O-methyltransferase Mus musculus 26-55 1350074-6 1992 The extraneuronal enzyme, catechol-O-methyl transferase (COMT), inactivates catecholamines by O-methylation, and its inhibition leads to increased levels of striatal DA. Catecholamines 76-90 catechol-O-methyltransferase Mus musculus 57-61 1350074-8 1992 The intraneuronal enzymes, monoamine oxidase (MAO)-A and MAO-B, inactivate catecholamines and other biogenic amines, such as serotonin, by deamination. Catecholamines 75-89 monoamine oxidase A Mus musculus 27-52 1350074-8 1992 The intraneuronal enzymes, monoamine oxidase (MAO)-A and MAO-B, inactivate catecholamines and other biogenic amines, such as serotonin, by deamination. Catecholamines 75-89 monoamine oxidase B Mus musculus 57-62 1620243-1 1992 The release of catecholamines and their coneurotransmitter neuropeptide Y (NPY) was investigated in conscious dogs with neurogenic arterial hypertension elicited by sinoaortic denervation. Catecholamines 15-29 neuropeptide Y Canis lupus familiaris 75-78 1325637-1 1992 Neuropeptide Y (NPY), first isolated in 1982, is widely distributed among the neurons of the central and peripheral nervous systems, often in close association with catecholamines. Catecholamines 165-179 neuropeptide Y Rattus norvegicus 16-19 1325637-4 1992 The ability of NPY to interact with the catecholamine transmission line may underly a possible modulatory influence of NPY on catecholamine receptor characteristics. Catecholamines 40-53 neuropeptide Y Rattus norvegicus 15-18 1325637-4 1992 The ability of NPY to interact with the catecholamine transmission line may underly a possible modulatory influence of NPY on catecholamine receptor characteristics. Catecholamines 40-53 neuropeptide Y Rattus norvegicus 119-122 1315817-9 1992 CONCLUSIONS: These findings suggest that, except for the heart, the SHR tissues observed overproduce NGF at a young age, leading to enhancement of peripheral sympathetic nervous system activity and the production of vasoconstrictive catecholamines. Catecholamines 233-247 nerve growth factor Rattus norvegicus 101-104 1540578-0 1992 Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis. Catecholamines 134-147 dopa decarboxylase Homo sapiens 82-117 1540578-1 1992 Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Catecholamines 247-261 dopa decarboxylase Homo sapiens 0-35 1540578-1 1992 Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Catecholamines 247-261 dopa decarboxylase Homo sapiens 37-41 1326931-0 1992 Role of atrial natriuretic peptide on calcium channel mechanisms involved in catecholamine release from bovine adrenal medulla. Catecholamines 77-90 natriuretic peptide A Bos taurus 8-34 1326931-1 1992 The role of the atrial natriuretic peptide on calcium channel mechanisms involved in catecholamine release was studied in the perfused bovine adrenal medulla. Catecholamines 85-98 natriuretic peptide A Bos taurus 16-42 1326931-3 1992 Ten nM of atrial natriuretic peptide decreased the output of catecholamines induced by acetylcholine, KCl-depolarizing solutions and angiotensin II. Catecholamines 61-75 natriuretic peptide A Bos taurus 10-36 1326931-6 1992 In conclusion, atrial natriuretic peptide inhibited the induced secretion of catecholamines in the bovine adrenal medulla and interfered as a partial blocker with calcium-dependent mechanisms. Catecholamines 77-91 natriuretic peptide A Bos taurus 15-41 1349592-5 1992 These data suggest that an excess of norepinephrine is present in polycystic ovary syndrome and that the hypophyseal response to LH-RH administration is correlated with catecholamine, especially norepinephrine activity. Catecholamines 169-182 gonadotropin releasing hormone 1 Homo sapiens 129-134 1737985-0 1992 Tumor necrosis factor modulates the inactivation of catecholamine secretion in cultured sympathetic neurons. Catecholamines 52-65 tumor necrosis factor Homo sapiens 0-21 1312137-0 1992 Demonstration of coexisting catecholamine (dopamine), amino acid (GABA), and peptide (NPY) involved in inhibition of melanotrope cell activity in Xenopus laevis: a quantitative ultrastructural, freeze-substitution immunocytochemical study. Catecholamines 28-41 neuropeptide Y S homeolog Xenopus laevis 86-89 1628451-0 1992 [Effects of insulin-induced hypoglycemia on catecholamine secretion and blood pressure in neurological disorders affecting autonomic nervous system]. Catecholamines 44-57 insulin Homo sapiens 12-19 1350645-1 1992 Neuropeptide Y (NPY) has a wide and specific distribution in the central nervous system, and is colocalized with catecholamines in specific neuronal systems. Catecholamines 113-127 neuropeptide Y Rattus norvegicus 0-20 1542654-2 1992 We generated a line of transgenic mice carrying a chimeric gene containing human PNMT cDNA fused to the 4-kilobase fragment of the human dopamine beta-hydroxylase (DBH) gene promoter, to switch catecholamine phenotype in the nervous and endocrine systems. Catecholamines 194-207 phenylethanolamine N-methyltransferase Homo sapiens 81-85 1542654-2 1992 We generated a line of transgenic mice carrying a chimeric gene containing human PNMT cDNA fused to the 4-kilobase fragment of the human dopamine beta-hydroxylase (DBH) gene promoter, to switch catecholamine phenotype in the nervous and endocrine systems. Catecholamines 194-207 dopamine beta-hydroxylase Homo sapiens 137-162 1542654-2 1992 We generated a line of transgenic mice carrying a chimeric gene containing human PNMT cDNA fused to the 4-kilobase fragment of the human dopamine beta-hydroxylase (DBH) gene promoter, to switch catecholamine phenotype in the nervous and endocrine systems. Catecholamines 194-207 dopamine beta-hydroxylase Homo sapiens 164-167 1542654-4 1992 Analysis of catecholamines in the various tissues showed that the expression of human PNMT in transgenic mice induced the appearance of epinephrine in sympathetic ganglion and dramatic changes in norepinephrine and epinephrine levels in brain, adrenal gland, and blood. Catecholamines 12-26 phenylethanolamine N-methyltransferase Homo sapiens 86-90 1545373-1 1992 Stimulation of either the 5-hydroxytryptamine (5-HT)1A, the 5-HT1C or the 5-HT2 receptor subtype triggers adrenal catecholamine release and hyperglycemia. Catecholamines 114-127 5-hydroxytryptamine receptor 2C Rattus norvegicus 60-66 1628451-1 1992 The effects of insulin-induced hypoglycemia on catecholamine secretion were investigated in patients with various neurological disorders affecting the autonomic nervous system. Catecholamines 47-60 insulin Homo sapiens 15-22 1349269-1 1992 We have studied the effects of basic fibroblast growth factor (bFGF), which occurs in the adrenal medulla, on the survival, morphological phenotype, storage capacity for catecholamines and induction of the synthesizing enzymes tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT) of cultured chromaffin cells from young postnatal rats. Catecholamines 170-184 fibroblast growth factor 2 Rattus norvegicus 63-67 1349269-3 1992 Basic FGF was also more effective than NGF in maintaining the initial storage capacity for catecholamines, and even increased it under certain culture conditions (laminin instead of polyornithine, or 200 ng instead of 40 ng/ml). Catecholamines 91-105 fibroblast growth factor 2 Rattus norvegicus 6-9 1547683-0 1992 Catecholamine response during human and pork insulin-induced hypoglycemia in IDDM patients. Catecholamines 0-13 insulin Homo sapiens 45-52 1577991-1 1992 Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species. Catecholamines 71-84 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 1577991-1 1992 Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species. Catecholamines 71-84 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 1547683-1 1992 OBJECTIVE: To evaluate the catecholamine response during human and pork insulin-induced hypoglycemia. Catecholamines 27-40 insulin Homo sapiens 72-79 1346640-1 1992 We reported previously that atrial natriuretic factor (ANF) and the ANF clearance receptor binding peptide, C-ANF(4-23)-NH2 (C-ANF), inhibit catecholamine (CA) release from rat, nerve growth factor-treated pheochromocytoma cells (PC12 cells) by a guanylate cyclase independent mechanism. Catecholamines 141-154 natriuretic peptide A Rattus norvegicus 28-53 1311009-0 1992 High plasma levels of catecholamines during insulin-induced hypoglycemic stress do not cause beta-adrenergic receptor sequestration. Catecholamines 22-36 insulin Homo sapiens 44-51 1534778-1 1992 The effects of atrial natriuretic factor (ANF) on the adreno-corticosteroid and catecholamine secretion of Xenopus laevis were studied in vitro and in vivo. Catecholamines 80-93 natriuretic peptide A L homeolog Xenopus laevis 15-40 1534778-1 1992 The effects of atrial natriuretic factor (ANF) on the adreno-corticosteroid and catecholamine secretion of Xenopus laevis were studied in vitro and in vivo. Catecholamines 80-93 natriuretic peptide A L homeolog Xenopus laevis 42-45 1349353-2 1992 We examined the dual immunocytochemical localization of antisera raised against Leu5-enkephalin and the catecholamine-synthesizing enzyme, tyrosine hydroxylase (TH), to determine the cellular substrates for these and/or other functional interactions. Catecholamines 104-117 tyrosine hydroxylase Rattus norvegicus 139-159 1349353-14 1992 The findings of the study provide anatomical substrates for multilevel interactions between catecholamines, mostly dopamine, and enkephalin in rat dorsal striatum. Catecholamines 92-106 proenkephalin Rattus norvegicus 129-139 1729391-5 1992 The time course of histamine-stimulated synapsin II phosphorylation closely paralleled that of histamine-stimulated catecholamine release. Catecholamines 116-129 synapsin II Bos taurus 40-51 1346640-1 1992 We reported previously that atrial natriuretic factor (ANF) and the ANF clearance receptor binding peptide, C-ANF(4-23)-NH2 (C-ANF), inhibit catecholamine (CA) release from rat, nerve growth factor-treated pheochromocytoma cells (PC12 cells) by a guanylate cyclase independent mechanism. Catecholamines 141-154 natriuretic peptide A Rattus norvegicus 55-58 1346640-1 1992 We reported previously that atrial natriuretic factor (ANF) and the ANF clearance receptor binding peptide, C-ANF(4-23)-NH2 (C-ANF), inhibit catecholamine (CA) release from rat, nerve growth factor-treated pheochromocytoma cells (PC12 cells) by a guanylate cyclase independent mechanism. Catecholamines 141-154 natriuretic peptide A Rattus norvegicus 68-71 1346640-1 1992 We reported previously that atrial natriuretic factor (ANF) and the ANF clearance receptor binding peptide, C-ANF(4-23)-NH2 (C-ANF), inhibit catecholamine (CA) release from rat, nerve growth factor-treated pheochromocytoma cells (PC12 cells) by a guanylate cyclase independent mechanism. Catecholamines 141-154 natriuretic peptide A Rattus norvegicus 68-71 1593369-5 1992 Altered hepatic metabolism of catecholamines due to growth hormone and cortisol deficiency may explain this observation. Catecholamines 30-44 growth hormone 1 Homo sapiens 52-66 1346640-1 1992 We reported previously that atrial natriuretic factor (ANF) and the ANF clearance receptor binding peptide, C-ANF(4-23)-NH2 (C-ANF), inhibit catecholamine (CA) release from rat, nerve growth factor-treated pheochromocytoma cells (PC12 cells) by a guanylate cyclase independent mechanism. Catecholamines 141-154 natriuretic peptide A Rattus norvegicus 68-71 1346644-2 1992 The purpose of this study was to examine effects of pretreatment of blood vessels with catecholamines on relaxant responses of the vessels to sodium nitroprusside (SNP) and atriopeptin III (ANF). Catecholamines 87-101 natriuretic peptide A Rattus norvegicus 190-193 1346644-10 1992 Changes in sensitivity of smooth muscle relaxation to SNP and ANF after prolonged exposure to catecholamines may relate to changes in capacity of the cyclic GMP system. Catecholamines 94-108 natriuretic peptide A Rattus norvegicus 62-65 19912846-2 1992 In this study, cellular distributions of mRNAs for the nerve growth factor (NGF) family of neurotrophins (NGF, BDNF, and NT-3) and the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) were evaluated in the ventral mesencephalon of adult rat to determine if the neurotrophins are synthesized in regions of the responsive dopaminergic cells. Catecholamines 135-148 tyrosine hydroxylase Rattus norvegicus 169-189 1343264-5 1992 Even potential vasoconstrictors such as vasopressin, catecholamines and serotonin release EDRF. Catecholamines 53-67 alpha hemoglobin stabilizing protein Homo sapiens 90-94 1589148-0 1992 Endothelin-3 stimulates the release of catecholamine from cortical and striatal slices of the rat. Catecholamines 39-52 endothelin 3 Rattus norvegicus 0-12 1309479-9 1992 Moreover, because beta 3AR mRNA was detected in rodent adipose tissues, liver, and muscle, we propose that the beta 3AR participates to the control by catecholamines of energy expenditure. Catecholamines 151-165 adrenoceptor beta 3 Homo sapiens 18-26 1309479-9 1992 Moreover, because beta 3AR mRNA was detected in rodent adipose tissues, liver, and muscle, we propose that the beta 3AR participates to the control by catecholamines of energy expenditure. Catecholamines 151-165 adrenoceptor beta 3 Homo sapiens 111-119 1463271-6 1992 Further studies employing dopamine receptor blockers and inhibitors of catecholamine synthesis indicated that the action of the peptide to block prolactin release was probably mediated by release of dopamine, which then inhibited prolactin release by the pituitary gland directly. Catecholamines 71-84 prolactin Rattus norvegicus 145-154 1370421-2 1992 In the present study, 2-aminopurine, which has been reported to selectively block c-fos gene expression, was used to test the hypothesis that c-fos protein might be involved in the desensitization to catecholamines was observed in 2-aminopurine-treated C6-2B rat glioma cells. Catecholamines 200-214 FBJ osteosarcoma oncogene Mus musculus 142-147 1358050-2 1992 TH was chosen as a marker for the sympathetic fibers because TH regulates the first step of catecholamine synthesis by converting tyrosine to dopa. Catecholamines 92-105 tyrosine 3-monooxygenase Cavia porcellus 0-2 1358050-2 1992 TH was chosen as a marker for the sympathetic fibers because TH regulates the first step of catecholamine synthesis by converting tyrosine to dopa. Catecholamines 92-105 tyrosine 3-monooxygenase Cavia porcellus 61-63 1600963-2 1992 Patients with chronic congestive heart failure (CHF) show down-regulation of the beta 1-adrenergic receptor with a decrease in receptor density and altered responses to catecholamines. Catecholamines 169-183 adrenoceptor beta 1 Homo sapiens 81-107 1351832-1 1992 The gene for tyrosine hydroxylase, the first and rate-limiting enzyme in the biosynthetic pathway of catecholamine neurotransmitters, has been localized in situ to chromosome 6 in the chicken. Catecholamines 101-114 tyrosine hydroxylase Gallus gallus 13-33 1314173-0 1992 Inter-relationships between pituitary-adrenal hormones and catecholamines during a 6-day Nordic ski race. Catecholamines 59-73 SKI proto-oncogene Homo sapiens 96-99 12106366-5 1992 The nature of these chromaffin cells was examined by immunocytochemistry using antibodies against the catecholamine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), which are capable of distinguishing between adrenergic and noradrenergic cells. Catecholamines 102-115 phenylethanolamine-N-methyltransferase Rattus norvegicus 136-174 1349535-0 1992 Is there a dopaminergic projection from the A11 catecholamine cell group to the amygdala? Catecholamines 48-61 DXS435E Homo sapiens 44-47 1349535-5 1992 The present study, in contrast to the previous report describing the dopaminergic innervation of the amygdala by the cells in and around the subparafascicular area (A11 catecholamine cell group), indicates that the A11 cell group does not contribute to a dopaminergic input to the amygdala. Catecholamines 169-182 DXS435E Homo sapiens 215-218 1369505-10 1992 We suggest that the increase of the adrenaline-induced hyperglycemia and the attenuation of the insulin-induced hypoglycemia could be linked to the release of catecholamines in the acute stage of the action of Digitalis glycosides. Catecholamines 159-173 insulin Oryctolagus cuniculus 96-103 1355073-2 1992 Alterations in dopaminergic and noradrenergic neurotransmission have been implicated in the pathogenesis of this disease, and tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of these two catecholamines. Catecholamines 210-224 tyrosine hydroxylase Homo sapiens 126-146 1355073-2 1992 Alterations in dopaminergic and noradrenergic neurotransmission have been implicated in the pathogenesis of this disease, and tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of these two catecholamines. Catecholamines 210-224 tyrosine hydroxylase Homo sapiens 148-150 1283768-5 1992 Catecholamines may raise total cholesterol, triglycerides, and insulin, decrease HDL cholesterol, and cause insulin resistance and glucose intolerance, and recent evidence supports an in vivo influence of epinephrine on blood platelets, causing dysfunction in hypertensive subjects. Catecholamines 0-14 insulin Homo sapiens 63-70 1283768-5 1992 Catecholamines may raise total cholesterol, triglycerides, and insulin, decrease HDL cholesterol, and cause insulin resistance and glucose intolerance, and recent evidence supports an in vivo influence of epinephrine on blood platelets, causing dysfunction in hypertensive subjects. Catecholamines 0-14 insulin Homo sapiens 108-115 12106366-5 1992 The nature of these chromaffin cells was examined by immunocytochemistry using antibodies against the catecholamine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), which are capable of distinguishing between adrenergic and noradrenergic cells. Catecholamines 102-115 phenylethanolamine-N-methyltransferase Rattus norvegicus 176-180 1551941-0 1992 Secretion of salivary immunoglobulin A in relation to age, saliva flow, mood states, secretion of albumin, cortisol, and catecholamines in saliva. Catecholamines 121-135 CD79a molecule Homo sapiens 22-38 1320891-1 1992 Neuropeptide Y, one of the most abundant polypeptides within the nervous system, is co-stored with catecholamines, especially norepinephrine (NE), thus suggesting its possible involvement in pathologies characterized by a noradrenergic impairment. Catecholamines 99-113 neuropeptide Y Homo sapiens 0-14 1312546-11 1992 CONCLUSIONS: We have already reported that BNP attenuated central endothelin-induced pressor response and plasma catecholamine secretion. Catecholamines 113-126 natriuretic peptide B Rattus norvegicus 43-46 1345770-8 1992 Thus, the regulation of rat adrenal medullary TH phosphorylation by nerve impulses is mediated by multiple first and second messenger systems, as previously shown for catecholamine secretion. Catecholamines 167-180 tyrosine hydroxylase Rattus norvegicus 46-48 1346629-6 1992 The results indicate that dopamine is the major catecholamine located in the laryngeal nerve paraganglia and show that ganglionic cells in the recurrent and superior laryngeal nerves show immunolabelling for one of the enzymes in the catecholamine synthetic pathway, dopamine-beta-hydroxylase. Catecholamines 234-247 dopamine beta-hydroxylase Rattus norvegicus 267-292 1640800-1 1992 Chromogranin A (CgA) is an acidic protein co-released with catecholamines during exocytosis from sympathetic nerve terminals and chromaffin cells. Catecholamines 59-73 chromogranin A Homo sapiens 0-14 1281506-0 1992 Synergistic action of cyclic GMP on catecholamine-induced chloride current in guinea-pig ventricular cells. Catecholamines 36-49 5'-nucleotidase, cytosolic II Homo sapiens 29-32 1281506-2 1992 Effects of cyclic GMP on the catecholamine-induced chloride current (ICl) were studied using the whole-cell patch-clamp technique combined with internal perfusion in single ventricular myocytes dispersed from guinea-pig heart. Catecholamines 29-42 5'-nucleotidase, cytosolic II Homo sapiens 18-21 1535395-5 1992 There were higher positive correlations between the levels of natural natriuretic factor and those of hormones of the renin-angiotensin-aldosterone system and catecholamines in patients having a diastolic pressure of greater than 115 mm Hg. Catecholamines 159-173 renin Homo sapiens 118-123 1640800-1 1992 Chromogranin A (CgA) is an acidic protein co-released with catecholamines during exocytosis from sympathetic nerve terminals and chromaffin cells. Catecholamines 59-73 chromogranin A Homo sapiens 16-19 1303778-3 1992 As we know procaterol has been included into group of beta-2-selective non-catecholamines with a reasonably long duration of action. Catecholamines 75-89 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 54-60 1351969-2 1992 The physiological effects of endogenous circulating catecholamines and exogenous adrenergic agonists in the lung are mediated by the beta 2-adrenergic receptor, which is present on a variety of cell types. Catecholamines 52-66 adrenoceptor beta 2 Homo sapiens 133-159 1738372-1 1992 Previous studies have demonstrated that in vitro treatment of adipocytes with catecholamines results in a decrease in the activity of the enzyme lipoprotein lipase (LPL). Catecholamines 78-92 lipoprotein lipase Rattus norvegicus 145-163 1738372-1 1992 Previous studies have demonstrated that in vitro treatment of adipocytes with catecholamines results in a decrease in the activity of the enzyme lipoprotein lipase (LPL). Catecholamines 78-92 lipoprotein lipase Rattus norvegicus 165-168 1817725-0 1991 Chromogranin A: localization and stoichiometry in large dense core catecholamine storage vesicles from sympathetic nerve. Catecholamines 67-80 chromogranin A Homo sapiens 0-14 1338161-4 1992 PEN patients demonstrated segmental vegetative disorders that manifested by reduced conduction in sweating fibers (a method of evoked cutaneous sympathetic potentials), a lowering of sympathetic effects in the cardiovascular system, a decline of diurnal excretion of catecholamines. Catecholamines 267-281 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 1765102-0 1991 Combined glyceraldehyde-3-phosphate dehydrogenase/phosphoglycerate kinase in catecholamine-stimulated guinea-pig cardiac muscle. Catecholamines 77-90 glyceraldehyde-3-phosphate dehydrogenase Cavia porcellus 9-49 1353277-7 1992 TH is a rate-limiting enzyme of catecholamine biosynthesis and deficiency of TH is an important feature of extra-adrenal non-functioning phaeochromocytomas. Catecholamines 32-45 tyrosine hydroxylase Homo sapiens 0-2 1817725-1 1991 Chromogranin A is present in both adrenal medullary chromaffin granules and sympathetic nerve large dense core catecholamine storage vesicles (LDVs), yet selective stimulation of sympathetic axons provokes only minor changes in chromogranin A in the circulation. Catecholamines 111-124 chromogranin A Homo sapiens 0-14 1817725-11 1991 Thus, only profound changes in exocytotic catecholamine release from sympathetic axon LDVs would be expected to perturb circulating chromogranin A concentrations. Catecholamines 42-55 chromogranin A Homo sapiens 132-146 1817730-7 1991 These results suggest that NE converted from L-threo-DOPS plays an important role in inducing LTP in the mossy fiber-CA3 system in the animals deficient in catecholamines. Catecholamines 156-170 carbonic anhydrase 3 Rattus norvegicus 117-120 1688031-0 1991 The peptide VIP is a neurotransmitter in rat adrenal medulla: physiological role in controlling catecholamine secretion. Catecholamines 96-109 vasoactive intestinal peptide Rattus norvegicus 12-15 1823883-13 1991 It is most likely that the adrenal renin plays a role in the production of aldosterone in the adrenal cortex or in the secretion of catecholamines from the adrenal medulla through intra- and/or extracellular formation of angiotensin II. Catecholamines 132-146 renin Rattus norvegicus 35-40 19215537-4 1991 Incubation of cells with carbamylcholine, nigh K(+) or histamine, three potent stimulators of catecholamine secretion in chromaffin cells, increased the rate of CGA and CGB synthesis. Catecholamines 94-107 chromogranin A Bos taurus 161-164 19215537-4 1991 Incubation of cells with carbamylcholine, nigh K(+) or histamine, three potent stimulators of catecholamine secretion in chromaffin cells, increased the rate of CGA and CGB synthesis. Catecholamines 94-107 chromogranin B Bos taurus 169-172 1688031-20 1991 The VIP receptor antagonist inhibited VIP-evoked secretion of catecholamines without affecting ACh-evoked secretion. Catecholamines 62-76 vasoactive intestinal peptide Rattus norvegicus 4-7 1688031-20 1991 The VIP receptor antagonist inhibited VIP-evoked secretion of catecholamines without affecting ACh-evoked secretion. Catecholamines 62-76 vasoactive intestinal peptide Rattus norvegicus 38-41 1667428-3 1991 The pressor response to TRH was blocked after depletion of catecholamines by i.p. Catecholamines 59-73 thyrotropin releasing hormone Rattus norvegicus 24-27 1784347-2 1991 In addition, recent studies have shown that activation of either the 5-HT1A, the 5-HT1C or the 5-HT2 receptor triggers adrenal catecholamine release. Catecholamines 127-140 5-hydroxytryptamine receptor 1A Rattus norvegicus 69-75 1667428-10 1991 Central serotonergic mechanisms rather than those related to catecholamines appear to be involved in the pressor response to TRH. Catecholamines 61-75 thyrotropin releasing hormone Rattus norvegicus 125-128 1784347-2 1991 In addition, recent studies have shown that activation of either the 5-HT1A, the 5-HT1C or the 5-HT2 receptor triggers adrenal catecholamine release. Catecholamines 127-140 5-hydroxytryptamine receptor 2C Rattus norvegicus 81-87 1723893-2 1991 Chromogranin A (CgA) is co-released with catecholamines and peptides and has a wide distribution in the brain. Catecholamines 41-55 chromogranin A Homo sapiens 0-14 1723893-2 1991 Chromogranin A (CgA) is co-released with catecholamines and peptides and has a wide distribution in the brain. Catecholamines 41-55 chromogranin A Homo sapiens 16-19 1682318-2 1991 Since tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and is regulated by second messenger systems known to be modulated by ethanol, we studied ethanol-induced changes in TH gene expression. Catecholamines 64-77 tyrosine hydroxylase Mus musculus 6-26 1682318-2 1991 Since tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and is regulated by second messenger systems known to be modulated by ethanol, we studied ethanol-induced changes in TH gene expression. Catecholamines 64-77 tyrosine hydroxylase Mus musculus 28-30 1935790-0 1991 Involvement of catecholamines in the effect of fasting on hepatic endothelial lipase activity in the rat. Catecholamines 15-29 lipase G, endothelial type Rattus norvegicus 66-84 1761139-12 1991 Immunohistochemical study of BAT showed localization of DBH in perivascular mesenchymal cells which corresponded with the morphologic distribution of catecholamine as reported by Lever. Catecholamines 150-163 dopamine beta-hydroxylase Rattus norvegicus 56-59 1932101-7 1991 This suggests that the lipolytic effect of TNF-alpha may be direct, whereas that of PAF is indirect, possibly via increased catecholamines in the sham-operated rats. Catecholamines 124-138 PCNA clamp associated factor Rattus norvegicus 84-87 1797336-11 1991 The release of catecholamines from chromaffin cells in response to milacemide (10(-4) M) was partially inhibited by the selective MAO-B inhibitors (-)-deprenyl (10(-7) M) and AGN 1135 (10(-6) M). Catecholamines 15-29 monoamine oxidase B Bos taurus 130-135 1797336-12 1991 This indicates that the MAO-B derived metabolites, glycineamide and glycine, contribute to the secretion of catecholamines as does milacemide itself. Catecholamines 108-122 monoamine oxidase B Bos taurus 24-29 1686923-2 1991 In this study, the effect of elevated KCl, under isotonic and hypertonic conditions, on the changes in mRNA levels of the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was compared. Catecholamines 122-135 dopamine beta-hydroxylase Rattus norvegicus 188-213 1686923-2 1991 In this study, the effect of elevated KCl, under isotonic and hypertonic conditions, on the changes in mRNA levels of the catecholamine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was compared. Catecholamines 122-135 dopamine beta-hydroxylase Rattus norvegicus 215-218 1791995-0 1991 c-Fos response to administration of catecholamines into brain by microdialysis. Catecholamines 36-50 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 0-5 1946455-4 1991 Thus, NGF mRNA was present, for example, in many motor nuclei and in the basal forebrain, and BDNF mRNA was seen in many nuclei in the brain stem and in catecholamine neurons, including dopamine neurons in the substantia nigra. Catecholamines 153-166 brain-derived neurotrophic factor Rattus norvegicus 94-98 1951755-6 1991 Plasma total catecholamine (norepinephrine + epinephrine) was increased in ANG II-salt rats (176 +/- 14 vs. 290 +/- 23 pg/ml, P less than 0.05), but Ca loading decreased plasma catecholamine (182 +/- 13 pg/ml, P less than 0.05). Catecholamines 13-26 angiotensinogen Rattus norvegicus 75-81 1786526-2 1991 We used the novel technique of brain microdialysis in conscious rats to investigate whether ANG II influences the release of endogenous catecholamines (CA) from the anterior hypothalamus (AH). Catecholamines 136-150 angiotensinogen Rattus norvegicus 92-98 1935790-12 1991 Those results suggest that catecholamines are involved in the decreased hepatic endothelial lipase activity found in the liver of fasted rats, and points out the role of these hormones in the acute modulation of an enzyme involved in reverse cholesterol transport. Catecholamines 27-41 lipase G, endothelial type Rattus norvegicus 80-98 1778660-5 1991 The decrease in the ability of insulin to either stimulate glucose transport or inhibit catecholamine induced lipolysis in SC cells was associated with a decrease in insulin receptor autophosphorylation and receptor tyrosine kinase activity. Catecholamines 88-101 insulin receptor Rattus norvegicus 166-182 1959929-5 1991 The regions that have been found to be linked to TSC in different families map to the positions of three enzymes, phenylalanine hydroxylase (12q22-24), tyrosinase (11q14-22), and dopamine-beta-hydroxylase (9q34), all of which are involved in the conversion of phenylalanine to catecholamine neurotransmitters or melanin. Catecholamines 277-290 phenylalanine hydroxylase Homo sapiens 114-139 1959929-5 1991 The regions that have been found to be linked to TSC in different families map to the positions of three enzymes, phenylalanine hydroxylase (12q22-24), tyrosinase (11q14-22), and dopamine-beta-hydroxylase (9q34), all of which are involved in the conversion of phenylalanine to catecholamine neurotransmitters or melanin. Catecholamines 277-290 dopamine beta-hydroxylase Homo sapiens 179-204 1717565-0 1991 Catecholamines stimulate the IFN-gamma-induced class II MHC expression on bovine brain capillary endothelial cells. Catecholamines 0-14 interferon gamma Bos taurus 29-38 1757773-3 1991 Fluorescent microscopy, following treatment of the ganglion with glyoxylic acid, showed that in both species only the SN1 neurones contained catecholamines. Catecholamines 141-155 solute carrier family 38 member 3 Homo sapiens 118-121 1757773-4 1991 A radioenzymatic assay for dopamine, performed on the locust SN1 neurones, confirmed that this catecholamine was present. Catecholamines 95-108 solute carrier family 38 member 3 Homo sapiens 61-64 1742021-4 1991 The expression pattern of the transgene in DBH-immunonegative sites overlapped with many sites where expression of tyrosine hydroxylase or phenylethanolamine N-methyltransferase, two other catecholamine biosynthetic enzymes, has been reported. Catecholamines 189-202 phenylethanolamine-N-methyltransferase Mus musculus 139-177 1769099-7 1991 The dose-responses of acetylcholine and catecholamine metabolisms to CDF are different, although the same molecule affects both transmitters. Catecholamines 40-53 LIF, interleukin 6 family cytokine Rattus norvegicus 69-72 1769099-8 1991 While the half-maximal concentrations for acetylcholine induction (0.20 nM) and for catecholamine suppression (0.28 nM) are similar, the response of catecholamine metabolism begins slowly and saturates at a CDF concentration (5-20 nM) considerably higher than that of acetylcholine (0.6 nM). Catecholamines 149-162 LIF, interleukin 6 family cytokine Rattus norvegicus 207-210 1769099-9 1991 This may indicate that CDF affects multiple processes in catecholamine metabolism. Catecholamines 57-70 LIF, interleukin 6 family cytokine Rattus norvegicus 23-26 1936584-2 1991 Physiological concentrations of insulin decrease the catecholamine-induced production of prostaglandin I2 (PGI2; prostacyclin) and PGE2, two potent vasodilators, in adipose tissue, one of the largest organs in the body. Catecholamines 53-66 insulin Homo sapiens 32-39 1662341-3 1991 The density of ET-1 receptors was measured by binding of [125I]ET-1 on rat astrocytoma C6 intact cells exposed to catecholamines, dibutyryl-cAMP or forskolin. Catecholamines 114-128 endothelin 1 Rattus norvegicus 15-19 1748061-6 1991 Our data suggested that aldose reductase inhibitors might be useful for the treatment of diabetic retinopathy, since the polyol pathway appears to be an important factor in its pathogenesis, and that catecholamines might have some role in the activation of the retinal polyol pathway. Catecholamines 200-214 aldo-keto reductase family 1 member B Homo sapiens 24-40 1680163-1 1991 Vasoactive intestinal peptide (VIP) increased catecholamine biosynthesis in bovine adrenal chromaffin cells by 50-200%. Catecholamines 46-59 vasoactive intestinal peptide Bos taurus 31-34 1680164-1 1991 Previous studies have shown that insulin-like growth factor-I (IGF-I) enhances secretagogue-stimulated Ca2+ uptake and catecholamine release in bovine chromaffin cells. Catecholamines 119-132 insulin like growth factor 1 Bos taurus 33-61 1680163-5 1991 VIP led to an elevation of cyclic AMP levels, and this increase occurred over a similar concentration range and time course as the activation of TH and the increase in catecholamine biosynthesis. Catecholamines 168-181 vasoactive intestinal peptide Bos taurus 0-3 1680164-1 1991 Previous studies have shown that insulin-like growth factor-I (IGF-I) enhances secretagogue-stimulated Ca2+ uptake and catecholamine release in bovine chromaffin cells. Catecholamines 119-132 insulin like growth factor 1 Bos taurus 63-68 1680164-2 1991 This report describes the effect of IGF-I on the activity of tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2), the major regulatory enzyme in the pathway of catecholamine biosynthesis. Catecholamines 170-183 insulin like growth factor 1 Bos taurus 36-41 1680163-9 1991 Our results indicate that VIP stimulates catecholamine biosynthesis in chromaffin cells through the phosphorylation and activation of TH and support the conclusion that a cyclic AMP-dependent phosphorylation of TH is responsible for these effects. Catecholamines 41-54 vasoactive intestinal peptide Bos taurus 26-29 1680164-2 1991 This report describes the effect of IGF-I on the activity of tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2), the major regulatory enzyme in the pathway of catecholamine biosynthesis. Catecholamines 170-183 tyrosine hydroxylase Bos taurus 83-107 1680163-9 1991 Our results indicate that VIP stimulates catecholamine biosynthesis in chromaffin cells through the phosphorylation and activation of TH and support the conclusion that a cyclic AMP-dependent phosphorylation of TH is responsible for these effects. Catecholamines 41-54 tyrosine hydroxylase Bos taurus 211-213 19912827-1 1991 6-hydroxydopamine (6-OHDA), a catecholamine neurotoxin, has been shown previously to induce degenerative changes in nerve terminals innervating proopiomelanocortin (POMC) cells of the pituitary intermediate lobe. Catecholamines 30-43 proopiomelanocortin Rattus norvegicus 165-169 1681086-0 1991 In vivo interactions between beta-1 and beta-2 adrenoceptors regulate catecholamine tachyphylaxia in human adipose tissue. Catecholamines 70-83 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 29-35 1681086-0 1991 In vivo interactions between beta-1 and beta-2 adrenoceptors regulate catecholamine tachyphylaxia in human adipose tissue. Catecholamines 70-83 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 40-46 1909899-0 1991 Insulin-like action of catecholamines and Ca2+ to stimulate glucose transport and GLUT4 translocation in perfused rat heart. Catecholamines 23-37 solute carrier family 2 member 4 Rattus norvegicus 82-87 1835732-9 1991 Postoperative catecholamines needed for P-1 was greater than P-2. Catecholamines 14-28 crystallin gamma F, pseudogene Homo sapiens 40-43 1688174-4 1991 These results suggest that SDZ HDC 912 may exhibit dopamine receptor agonistic effect under certain conditions, such as supersensitivity and/or catecholamine depletion. Catecholamines 144-157 histidine decarboxylase Mus musculus 31-34 1686575-7 1991 This function of NGF might be considered as an inhibitory feedback mechanism against catecholamine-stimulated NGF synthesis. Catecholamines 85-98 nerve growth factor Rattus norvegicus 17-20 1686575-7 1991 This function of NGF might be considered as an inhibitory feedback mechanism against catecholamine-stimulated NGF synthesis. Catecholamines 85-98 nerve growth factor Rattus norvegicus 110-113 1681489-4 1991 Under somatostatin infusion the urinary excretion of catecholamines, PGE2, PGF2 alfa and the plasma renin activity and the plasma concentration of glucagon and growth hormone decrease. Catecholamines 53-67 somatostatin Homo sapiens 6-18 1684650-3 1991 We cloned full-length complementary DNAs (cDNAs) and genomic DNAs of human catecholamine-synthesizing enzymes (TH, AADC, DBH, PNMT) and determined the nucleotide sequences and the deduced amino acid sequences. Catecholamines 75-88 dopa decarboxylase Homo sapiens 115-119 1684650-3 1991 We cloned full-length complementary DNAs (cDNAs) and genomic DNAs of human catecholamine-synthesizing enzymes (TH, AADC, DBH, PNMT) and determined the nucleotide sequences and the deduced amino acid sequences. Catecholamines 75-88 dopamine beta-hydroxylase Homo sapiens 121-124 1684650-3 1991 We cloned full-length complementary DNAs (cDNAs) and genomic DNAs of human catecholamine-synthesizing enzymes (TH, AADC, DBH, PNMT) and determined the nucleotide sequences and the deduced amino acid sequences. Catecholamines 75-88 phenylethanolamine N-methyltransferase Homo sapiens 126-130 1933373-4 1991 However, norepinephrine infusion in combination with ANG II injection restored the drinking response to ANG II in rats with catecholamine depletions of the lamina terminalis region. Catecholamines 124-137 angiotensinogen Rattus norvegicus 53-59 1666613-4 1991 Stress, catecholamines sharply increased the sensitivity of coronary vessels of old rats to vasopressin. Catecholamines 8-22 arginine vasopressin Rattus norvegicus 92-103 1861147-1 1991 Earlier studies have shown that bradykinin stimulated release of catecholamines from chromaffin cells by an influx of calcium through dihydropyridine-insensitive channels, and also that bradykinin stimulated (poly)phosphoinositide hydrolysis. Catecholamines 65-79 kininogen 1 Bos taurus 32-42 8577141-3 1991 The subjects with a higher insulin in plasma and renal excretion of catecholamines showed a longer time of tolerance to the above exposure which varied from 50 to 120 min. Catecholamines 68-82 insulin Homo sapiens 27-34 1747753-2 1991 We used antisera against the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), and one against the transmitter serotonin (5-HT). Catecholamines 29-42 dopamine beta-hydroxylase Rattus norvegicus 91-116 1879614-6 1991 At this stage the adult cuticle is unsclerotized and unpigmented and dopa decarboxylase levels, a key enzyme in catecholamine metabolism which provides the crosslinking agents as well as the precursors for melanin, is low. Catecholamines 112-125 Dopa decarboxylase Drosophila melanogaster 69-87 1832677-0 1991 The participation of annexin II (calpactin I) in calcium-evoked exocytosis requires protein kinase C. Permeabilized adrenal chromaffin cells secrete catecholamines by exocytosis in response to micromolar calcium concentrations. Catecholamines 149-163 annexin A2 Homo sapiens 21-31 1861155-6 1991 Addition of tetrabenazine, an inhibitor of catecholamine uptake into chromaffin vesicles, during radiolabeling and a 6-h chase period caused enhanced proenkephalin processing. Catecholamines 43-56 proenkephalin Bos taurus 150-163 1758263-1 1991 This study was designed to determine the presence and different levels of placental neuropeptide Y (NPY) in women at parturition between normal spontaneous delivery (NSD) and cesarean section (C/S) under spinal anesthesia and to compare it with the level of catecholamines. Catecholamines 258-272 neuropeptide Y Homo sapiens 84-98 1758263-1 1991 This study was designed to determine the presence and different levels of placental neuropeptide Y (NPY) in women at parturition between normal spontaneous delivery (NSD) and cesarean section (C/S) under spinal anesthesia and to compare it with the level of catecholamines. Catecholamines 258-272 neuropeptide Y Homo sapiens 100-103 1660576-0 1991 Differential effects of protein kinase C activation on catecholamine secretions evoked by stimulations of various receptors in the rat adrenal medulla. Catecholamines 55-68 protein kinase C, gamma Rattus norvegicus 24-40 1747753-2 1991 We used antisera against the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), and one against the transmitter serotonin (5-HT). Catecholamines 29-42 dopamine beta-hydroxylase Rattus norvegicus 118-121 1747753-2 1991 We used antisera against the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT), and one against the transmitter serotonin (5-HT). Catecholamines 29-42 phenylethanolamine-N-methyltransferase Rattus norvegicus 167-171 1933373-4 1991 However, norepinephrine infusion in combination with ANG II injection restored the drinking response to ANG II in rats with catecholamine depletions of the lamina terminalis region. Catecholamines 124-137 angiotensinogen Rattus norvegicus 104-110 1685006-2 1991 In order to delineate the role of cell aggregation and nerve growth factor (NGF) in regulating catecholamine expression, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) mRNA levels were examined in PC12 cells at different cell densities with and without NGF treatment. Catecholamines 95-108 nerve growth factor Rattus norvegicus 76-79 1719746-10 1991 The data suggest that galanin-like immunoreactivity and neuropeptide Y-like immunoreactivity are partly stored with catecholamines in chromaffin granules. Catecholamines 116-130 pro-neuropeptide Y Cavia porcellus 56-70 1893643-4 1991 For example, ACE inhibitors decrease angiotensin II-mediated vasoconstriction, reduce adrenal medullary catecholamine release, restore baroreceptor activity, and normalize vasomotor sympathetic activity. Catecholamines 104-117 angiotensin I converting enzyme Homo sapiens 13-16 1893645-3 1991 The benefits of ACE inhibition include not only a reduction in blood pressure but also improved insulin responsiveness, prevention of potassium loss, diminished myocardial oxygen demand, suppression of catecholamines, and interaction with bradykinin and prostaglandins. Catecholamines 202-216 angiotensin I converting enzyme Homo sapiens 16-19 1956581-5 1991 Since BH4, NADH and DHPR are ubiquitous in mammalian tissues, this system may play an important role in the reduction of the oxidation products of catecholamines. Catecholamines 147-161 quinoid dihydropteridine reductase Homo sapiens 20-24 1668161-1 1991 Administration of corticoliberin to dorsal hippocampus through implanted chemotrodes decreased the number of positive salivary conditioned and unconditioned reflexes, enhanced their variability, reduced motor activity and food excitability, decreased the pulse and respiration rate, enhanced the contents of cortisol, vasopressin, catecholamines in the blood of dogs. Catecholamines 331-345 corticotropin releasing hormone Canis lupus familiaris 18-32 1922677-1 1991 This is an investigation of the effects of active immunization against gonadotrophin-releasing hormone (GnRH) conjugated to keyhole limpet hemocyanin on brain and male sexual organ concentration of catecholamines and 5-hydroxytryptamine. Catecholamines 198-212 gonadotropin releasing hormone 1 Rattus norvegicus 71-102 1922677-1 1991 This is an investigation of the effects of active immunization against gonadotrophin-releasing hormone (GnRH) conjugated to keyhole limpet hemocyanin on brain and male sexual organ concentration of catecholamines and 5-hydroxytryptamine. Catecholamines 198-212 gonadotropin releasing hormone 1 Rattus norvegicus 104-108 1909680-1 1991 The Drosophila melanogaster diphenol oxidase (DOX) A2-encoding gene (Dox-A2) is involved in catecholamine metabolism, melanin formation and sclerotization of the cuticle. Catecholamines 92-105 Regulatory particle non-ATPase 3 Drosophila melanogaster 69-75 1685739-1 1991 We have measured levels of mRNA coding for the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (D beta H), phenylethanolamine N-methyltransferase (PNMT) and for neuropeptide Y (NPY) in rat adrenal medulla by using in situ hybridization histochemistry. Catecholamines 47-60 tyrosine hydroxylase Rattus norvegicus 82-102 1685739-1 1991 We have measured levels of mRNA coding for the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (D beta H), phenylethanolamine N-methyltransferase (PNMT) and for neuropeptide Y (NPY) in rat adrenal medulla by using in situ hybridization histochemistry. Catecholamines 47-60 tyrosine hydroxylase Rattus norvegicus 104-106 1685739-1 1991 We have measured levels of mRNA coding for the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (D beta H), phenylethanolamine N-methyltransferase (PNMT) and for neuropeptide Y (NPY) in rat adrenal medulla by using in situ hybridization histochemistry. Catecholamines 47-60 phenylethanolamine-N-methyltransferase Rattus norvegicus 187-191 1685739-1 1991 We have measured levels of mRNA coding for the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (D beta H), phenylethanolamine N-methyltransferase (PNMT) and for neuropeptide Y (NPY) in rat adrenal medulla by using in situ hybridization histochemistry. Catecholamines 47-60 neuropeptide Y Rattus norvegicus 201-215 1685739-1 1991 We have measured levels of mRNA coding for the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (D beta H), phenylethanolamine N-methyltransferase (PNMT) and for neuropeptide Y (NPY) in rat adrenal medulla by using in situ hybridization histochemistry. Catecholamines 47-60 neuropeptide Y Rattus norvegicus 217-220 1895364-8 1991 Fat is mobilized from adipose tissue in response to stimulation of an intracellular lipase by the catecholamines. Catecholamines 98-112 FAT atypical cadherin 1 Homo sapiens 0-3 1685558-4 1991 The beta 2AR-mediated responses to the catecholamines, disclosed by CGP 20,712 A, were verified by blockade with the beta 2AR-selective ICI 118,551. Catecholamines 39-53 adrenoceptor beta 2 Homo sapiens 4-12 1685558-4 1991 The beta 2AR-mediated responses to the catecholamines, disclosed by CGP 20,712 A, were verified by blockade with the beta 2AR-selective ICI 118,551. Catecholamines 39-53 adrenoceptor beta 2 Homo sapiens 117-125 1918805-3 1991 The number of catecholamine-containing neurons in the A11 group in the rat was estimated to be 173 +/- 4. Catecholamines 14-27 selectin L Rattus norvegicus 54-57 1884235-4 1991 In addition, unilateral vsubLC lesions dramatically reduced the catecholamine innervation of the ipsilateral paraventricular nucleus (PVN), as qualitatively determined with dopamine beta-hydroxylase immunocytochemistry, suggesting that a pathway ascending with catecholaminergic fibers was disrupted. Catecholamines 64-77 dopamine beta-hydroxylase Rattus norvegicus 173-198 1713332-4 1991 The effectiveness of anti-NGF treatment was monitored by viewing catecholamine (CA)-containing nerves, which were virtually absent from the blood vessels, but were little affected in the vas deferens and bladder in both age groups. Catecholamines 65-78 nerve growth factor Rattus norvegicus 26-29 1652275-4 1991 Chronic exposure (days or months), but not acute exposure (hours), to a catecholamine downregulates human heart beta 1AR. Catecholamines 72-85 adrenoceptor beta 1 Homo sapiens 112-120 1653068-5 1991 Catecholamines inhibited this process with an order of potency: isoprenaline greater than adrenaline greater than noradrenaline indicating involvement of beta 2-adrenoceptors. Catecholamines 0-14 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 154-160 1682018-1 1991 Immunohistochemical distributions of tyrosine hydroxylase and calmodulin in the rat forebrain were analyzed quantitatively to confirm our previous results that the activities of central catecholamine-synthesizing enzymes are regulated by a calcium-calmodulin-dependent system. Catecholamines 186-199 calmodulin 1 Rattus norvegicus 62-72 1682018-1 1991 Immunohistochemical distributions of tyrosine hydroxylase and calmodulin in the rat forebrain were analyzed quantitatively to confirm our previous results that the activities of central catecholamine-synthesizing enzymes are regulated by a calcium-calmodulin-dependent system. Catecholamines 186-199 calmodulin 1 Rattus norvegicus 248-258 1682018-8 1991 These findings suggest that the synthesis of central catecholamines is regulated by a calcium-calmodulin-dependent system. Catecholamines 53-67 calmodulin 1 Rattus norvegicus 94-104 2068891-3 1991 Histamine stimulates the secretion of ACTH, beta-endorphin (mediated by CRH and AVP), alpha-MSH (mediated by dopamine and peripheral catecholamines), and PRL (mediated by dopamine, serotonin and AVP), and participates in the stress-induced release of these hormones and possibly in the suckling- and estrogen-induced PRL release. Catecholamines 133-147 proopiomelanocortin Homo sapiens 86-95 1859148-3 1991 Dobutamine is a synthetic catecholamine that acts on alpha-1, beta-1 and beta-2 adrenergic receptors. Catecholamines 26-39 adrenoceptor alpha 1D Homo sapiens 53-68 1859148-3 1991 Dobutamine is a synthetic catecholamine that acts on alpha-1, beta-1 and beta-2 adrenergic receptors. Catecholamines 26-39 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 73-79 1652275-7 1991 In human heart, catecholamine-induced activation of one beta 2AR causes the production of at least four times more cyclic AMP than activation of one beta 1AR. Catecholamines 16-29 adrenoceptor beta 2 Homo sapiens 56-64 1652275-7 1991 In human heart, catecholamine-induced activation of one beta 2AR causes the production of at least four times more cyclic AMP than activation of one beta 1AR. Catecholamines 16-29 adrenoceptor beta 1 Homo sapiens 149-157 1675550-2 1991 Epinine is one of the few catecholamines that possess dopaminergic--DA1 and DA2--activity, alpha 1, alpha 2, beta 1, and beta 2 activity, with indirect sympathomimetic action of dopamine. Catecholamines 26-40 tropomyosin 2 Homo sapiens 68-71 1810694-1 1991 During three consecutive days of prazosin treatment in a patient with pheochromocytoma, urinary catecholamine metabolite levels were correlated with plasma renin activity. Catecholamines 96-109 renin Homo sapiens 156-161 1810694-3 1991 This suggests that prazosin may interrupt the vicious cycle of worsening hypertension provoked by further activation of the renin-angiotensin system mediated by excessive circulating catecholamines. Catecholamines 183-197 renin Homo sapiens 124-129 1680842-3 1991 A noradrenergic component was demonstrated by immunoreactivity (IR) of the catecholamine-synthesising enzymes tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in neuronal perikarya. Catecholamines 75-88 dopamine beta-hydroxylase Cavia porcellus 167-170 2045576-3 1991 The pattern of localization suggests that COMT may function in extraneuronal inactivation of catecholamines in dental pulp. Catecholamines 93-107 catechol-O-methyltransferase Rattus norvegicus 42-46 19912803-1 1991 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, has been reported to be present in interneurons in human cerebral cortex. Catecholamines 55-68 tyrosine hydroxylase Homo sapiens 0-20 19912803-1 1991 Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, has been reported to be present in interneurons in human cerebral cortex. Catecholamines 55-68 tyrosine hydroxylase Homo sapiens 22-24 1852128-0 1991 Evidence that beta 2-receptors mediate action of catecholamines on endolymphatic sac DC potential. Catecholamines 49-63 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 14-20 1674642-7 1991 Thus we conclude that sympathochromaffin activation plays a minor role when insulin and glucagon are operative, but a catecholamine, probably epinephrine, becomes critical to the prevention of hypoglycemia during exercise when changes in insulin and glucagon do not occur. Catecholamines 118-131 insulin Homo sapiens 238-245 1849789-1 1991 Catecholamines are involved critically in the mechanisms of liver cell proliferation by acting on hepatic alpha-1 and beta-2 adrenoceptors. Catecholamines 0-14 adrenoceptor alpha 1D Homo sapiens 106-113 1849789-1 1991 Catecholamines are involved critically in the mechanisms of liver cell proliferation by acting on hepatic alpha-1 and beta-2 adrenoceptors. Catecholamines 0-14 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 118-124 1680272-2 1991 Tyrosine hydroxylase (TH) immunoreactivity was used as a marker of catecholamine synthesis. Catecholamines 67-80 tyrosine hydroxylase Rattus norvegicus 0-20 1852128-1 1991 Our recent study has revealed that catecholamines depress the endolymphatic sac direct current potential (ESP) by the beta-adrenergic action [Mori et al., Am. Catecholamines 35-49 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 106-109 1852128-10 1991 The results indicate that beta 2-receptors mediate the action of catecholamines on the ESP. Catecholamines 65-79 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 26-32 1852128-10 1991 The results indicate that beta 2-receptors mediate the action of catecholamines on the ESP. Catecholamines 65-79 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 87-90 1687976-3 1991 Synthetic oligonucleotide probes complementary to mRNA coding for the catecholamine synthesizing enzymes phenylethanolamine N-methyltransferase (PNMT), tyrosine hydroxylase (TH) and NPY were used to analyse the regulation of these genes following administration of the catecholamine depleting drug reserpine. Catecholamines 70-83 phenylethanolamine N-methyltransferase Homo sapiens 105-143 1687976-3 1991 Synthetic oligonucleotide probes complementary to mRNA coding for the catecholamine synthesizing enzymes phenylethanolamine N-methyltransferase (PNMT), tyrosine hydroxylase (TH) and NPY were used to analyse the regulation of these genes following administration of the catecholamine depleting drug reserpine. Catecholamines 70-83 phenylethanolamine N-methyltransferase Homo sapiens 145-149 1680175-11 1991 Acetylcholine-induced catecholamine release was accompanied by increased dopamine-beta-hydroxylase release, whereas pentazocine-induced catecholamine efflux was not. Catecholamines 22-35 dopamine beta-hydroxylase Canis lupus familiaris 73-98 1860789-13 1991 The decreased serum IL-2 level, observed in this study, might reflect a reduction in 5-HT or catecholamine levels in CNS in the patients with migraine or TH. Catecholamines 93-106 interleukin 2 Homo sapiens 20-24 1747158-5 1991 It is concluded that inhibition of IACh probably represents the mechanism by which NPY decreases catecholamine release from adrenal medulla. Catecholamines 97-110 neuropeptide Y Bos taurus 83-86 2012249-4 1991 Total catecholamine secretion during insulin-induced hypoglycemia was significantly lower in the RO. Catecholamines 6-19 insulin Homo sapiens 37-44 1926973-10 1991 There is discussed that persisting anxious hostile behaviour is able to induce PIH by catecholamine-prostaglandin-mechanism. Catecholamines 86-99 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 79-82 1882084-0 1991 Neural influence on oxytocin-induced changes of adrenomedullary catecholamines in the pigeon. Catecholamines 64-78 oxytocin/neurophysin I prepropeptide Homo sapiens 20-28 1848811-1 1991 The alpha 1-adrenergic receptor mediates the effects of catecholamines on DNA synthesis, as observed in rat liver following a 2/3 partial hepatectomy and in serum-free primary cultures of adult rat hepatocytes exposed to epidermal growth factor. Catecholamines 56-70 epidermal growth factor like 1 Rattus norvegicus 221-244 1716525-6 1991 The elevated levels of proteinase inhibitors in late gestoses support the view on a possibly impaired coagulation equilibrium in late gestoses, and the high ceruloplasmin levels suggest an enhanced catecholamine breakdown during the stress alarm reaction. Catecholamines 198-211 ceruloplasmin Homo sapiens 157-170 1716298-1 1991 Previous work has demonstrated that catecholamine-containing cells differentiate preferentially from populations of quail trunk neural crest cells isolated by cell sorting using the HNK-1 antibody (Maxwell, Forbes, and Christie, 1988). Catecholamines 36-49 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus 182-187 1716298-4 1991 Twice as many catecholamine-positive and total cells developed from the brightest third of the HNK-1+ cells compared to the remaining HNK-1+ cells, but the proportion of catecholamine-containing cells was similar in both populations. Catecholamines 14-27 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus 95-100 2071822-0 1991 Is prolactin playing a role in the regulation of catecholamine synthesis and release from male rat adrenal medulla? Catecholamines 49-62 prolactin Rattus norvegicus 3-12 1658840-9 1991 These results demonstrate a reciprocal potentiation of NPY and alpha 2 agonists in the brainstem, and suggest that NPY and catecholamines interact in central cardiovascular regulation. Catecholamines 123-137 neuropeptide Y Rattus norvegicus 55-58 1672315-2 1991 Tyrosine hydroxylase, which catalyzes the initial step in catecholamine biosynthesis, is phosphorylated at serines 8, 19, 31, and 40 in intact pheochromocytoma (PC12) cells (Haycock, J.W. Catecholamines 58-71 tyrosine hydroxylase Rattus norvegicus 0-20 1677301-2 1991 Acute stress induces norepinephrine synthesis and release, and noradrenergic cells compensate by increasing the activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis. Catecholamines 174-187 tyrosine hydroxylase Rattus norvegicus 124-144 1676862-2 1991 Previous studies have suggested a stimulating effect of catecholamines on ANF release. Catecholamines 56-70 natriuretic peptide A Homo sapiens 74-77 1676862-6 1991 We concluded that chronic elevation of basal catecholamines are without effect on plasma ANF but that manipulation of pheochromocytoma leads to a stimulation of ANF release, possibly mediated by either a direct effect of endogenously released catecholamines and/or an increase in atrial pressure. Catecholamines 243-257 natriuretic peptide A Homo sapiens 161-164 1673823-1 1991 The present immunocytochemical study used an antiserum to tyrosine hydroxylase (TH), the first enzyme in the biosynthetic pathway of catecholamines, and revealed TH immunoreactivity in the ganglion cells and in the varicose nerve fibers of the cortex and medulla in the rat adrenal gland. Catecholamines 133-147 tyrosine hydroxylase Rattus norvegicus 58-78 1673823-1 1991 The present immunocytochemical study used an antiserum to tyrosine hydroxylase (TH), the first enzyme in the biosynthetic pathway of catecholamines, and revealed TH immunoreactivity in the ganglion cells and in the varicose nerve fibers of the cortex and medulla in the rat adrenal gland. Catecholamines 133-147 tyrosine hydroxylase Rattus norvegicus 80-82 1673823-1 1991 The present immunocytochemical study used an antiserum to tyrosine hydroxylase (TH), the first enzyme in the biosynthetic pathway of catecholamines, and revealed TH immunoreactivity in the ganglion cells and in the varicose nerve fibers of the cortex and medulla in the rat adrenal gland. Catecholamines 133-147 tyrosine hydroxylase Rattus norvegicus 162-164 2071822-1 1991 Previous evidence allows one to suspect that prolactin (PRL) may be a physiological regulator of catecholamine (CA) synthesis and release in the adrenal gland of rodents. Catecholamines 97-110 prolactin Rattus norvegicus 45-54 2071822-1 1991 Previous evidence allows one to suspect that prolactin (PRL) may be a physiological regulator of catecholamine (CA) synthesis and release in the adrenal gland of rodents. Catecholamines 97-110 prolactin Rattus norvegicus 56-59 1675919-0 1991 Central nervous system site of action of bombesin to elevate plasma concentrations of catecholamines. Catecholamines 86-100 gastrin releasing peptide Homo sapiens 41-49 1993889-1 1991 In previous studies it has been shown that both bradykinin and histamine increase the formation of 3H-labeled inositol phosphates in adrenal chromaffin cells prelabelled with [3H]inositol and that both these agonists stimulate release of catecholamines by a mechanism dependent on extracellular calcium. Catecholamines 238-252 kininogen 1 Homo sapiens 48-58 1871416-4 1991 The results showed that ANG II stimulates catecholamine metabolism in the CNS. Catecholamines 42-55 angiotensinogen Rattus norvegicus 24-30 1675919-1 1991 To identify the central nervous system site of action of bombesin to elevate plasma concentrations of catecholamines, this peptide has been injected into numerous brain ventricular and parenchymal sites. Catecholamines 102-116 gastrin releasing peptide Homo sapiens 57-65 1675919-2 1991 Low doses of bombesin (1-10 ng) injected into the region of the rostral nucleus tractus solitarius (NTS) elicited an elevation of plasma catecholamines greater than those observed following an injection of bombesin into other brain regions. Catecholamines 137-151 gastrin releasing peptide Homo sapiens 13-21 1709847-2 1991 A cohort of brain neurotransmitters, especially catecholamines and acetylcholine, play a crucial role in the control of neurosecretory growth hormone-releasing hormone (GH-RH)- and somatostatin (SS)-producing neurons, and hence growth hormone (GH) secretion. Catecholamines 48-62 growth hormone releasing hormone Homo sapiens 135-167 1675919-6 1991 These studies demonstrate that bombesin injected into the dorsal medulla resulted in significant changes of plasma catecholamine levels and HR. Catecholamines 115-128 gastrin releasing peptide Homo sapiens 31-39 1996343-3 1991 Here we cleaved CGA purified from bovine chromaffin granules with endoproteinase Lys-C, and we isolated and partially sequenced the peptide inhibiting catecholamine secretion from cultured chromaffin cells. Catecholamines 151-164 chromogranin A Bos taurus 16-19 1992709-4 1991 The other enzyme of catecholamine metabolism, catechol-O-methyltransferase, did not show any difference in activity between the two layers. Catecholamines 20-33 catechol-O-methyltransferase Homo sapiens 46-74 2049814-6 1991 Elevated pulse rates, early hyperglycemia, late hypoglycemia, hyperlactacidemia, hypoinsulinemia, and elevated catecholamine concentrations were evident after injection of 1.0 mg/kg TNF. Catecholamines 111-124 tumor necrosis factor Rattus norvegicus 182-185 1709847-2 1991 A cohort of brain neurotransmitters, especially catecholamines and acetylcholine, play a crucial role in the control of neurosecretory growth hormone-releasing hormone (GH-RH)- and somatostatin (SS)-producing neurons, and hence growth hormone (GH) secretion. Catecholamines 48-62 growth hormone releasing hormone Homo sapiens 169-174 1709847-2 1991 A cohort of brain neurotransmitters, especially catecholamines and acetylcholine, play a crucial role in the control of neurosecretory growth hormone-releasing hormone (GH-RH)- and somatostatin (SS)-producing neurons, and hence growth hormone (GH) secretion. Catecholamines 48-62 growth hormone 1 Homo sapiens 135-149 2060427-7 1991 RESULTS: Basal plasma catecholamine levels were lower in diabetic subjects after intensive insulin therapy than in control subjects (P = 0.008). Catecholamines 22-35 insulin Homo sapiens 91-98 2060427-8 1991 The peak and incremental catecholamine responses after insulin withdrawal and intensive insulin therapy in IDDM subjects were significantly decreased compared with control subjects (P less than 0.001). Catecholamines 25-38 insulin Homo sapiens 55-62 1709847-2 1991 A cohort of brain neurotransmitters, especially catecholamines and acetylcholine, play a crucial role in the control of neurosecretory growth hormone-releasing hormone (GH-RH)- and somatostatin (SS)-producing neurons, and hence growth hormone (GH) secretion. Catecholamines 48-62 growth hormone 1 Homo sapiens 169-171 2060427-8 1991 The peak and incremental catecholamine responses after insulin withdrawal and intensive insulin therapy in IDDM subjects were significantly decreased compared with control subjects (P less than 0.001). Catecholamines 25-38 insulin Homo sapiens 88-95 1996081-3 1991 Northern blot analysis of NGF mRNA, in combination with a two-site enzyme immunoassay for NGF, showed that depletion of catecholamines was associated with a 3-fold increase in NGF mRNA, which was followed by a significant increase in the NGF content of cerebral cortex. Catecholamines 120-134 nerve growth factor Rattus norvegicus 26-29 2060427-9 1991 Peak catecholamine responses to hypoglycemia in IDDM were decreased after intensive insulin therapy (P = 0.002). Catecholamines 5-18 insulin Homo sapiens 84-91 2060427-11 1991 The diminished catecholamine responses were primarily due to decreased peak epinephrine responses after intensive insulin therapy compared with insulin withdrawal (P = 0.011). Catecholamines 15-28 insulin Homo sapiens 114-121 2060427-13 1991 CONCLUSIONS: These results suggest that children and adolescents with IDDM after insulin withdrawal have diminished catecholamine response to hypoglycemia compared with control subjects and indicate that short-term intensive insulin therapy diminishes this response further. Catecholamines 116-129 insulin Homo sapiens 81-88 2060427-13 1991 CONCLUSIONS: These results suggest that children and adolescents with IDDM after insulin withdrawal have diminished catecholamine response to hypoglycemia compared with control subjects and indicate that short-term intensive insulin therapy diminishes this response further. Catecholamines 116-129 insulin Homo sapiens 225-232 1988560-2 1991 This analgesia most likely results from the release of neuroactive substances, particularly catecholamines and opioid peptides, from the transplanted cells into the CSF of the spinal cord, since it can be attenuated or blocked by alpha-adrenergic or opiate antagonists. Catecholamines 92-106 colony stimulating factor 2 Rattus norvegicus 165-168 1988560-3 1991 The purpose of the present study was to more directly measure the release of catecholamines from adrenal medullary transplants in the spinal cord CSF using a spinal superfusion technique. Catecholamines 77-91 colony stimulating factor 2 Rattus norvegicus 146-149 1996081-3 1991 Northern blot analysis of NGF mRNA, in combination with a two-site enzyme immunoassay for NGF, showed that depletion of catecholamines was associated with a 3-fold increase in NGF mRNA, which was followed by a significant increase in the NGF content of cerebral cortex. Catecholamines 120-134 nerve growth factor Rattus norvegicus 90-93 1996081-3 1991 Northern blot analysis of NGF mRNA, in combination with a two-site enzyme immunoassay for NGF, showed that depletion of catecholamines was associated with a 3-fold increase in NGF mRNA, which was followed by a significant increase in the NGF content of cerebral cortex. Catecholamines 120-134 nerve growth factor Rattus norvegicus 90-93 1996081-3 1991 Northern blot analysis of NGF mRNA, in combination with a two-site enzyme immunoassay for NGF, showed that depletion of catecholamines was associated with a 3-fold increase in NGF mRNA, which was followed by a significant increase in the NGF content of cerebral cortex. Catecholamines 120-134 nerve growth factor Rattus norvegicus 90-93 1671550-4 1991 Under the same conditions, induction of tyrosine aminotransferase by dexamethasone is not significantly affected by catecholamine availability, which altogether demonstrates that rat liver ornithine decarboxylase activity is specifically governed by the interaction between glucocorticoids and catecholamines. Catecholamines 294-308 ornithine decarboxylase 1 Rattus norvegicus 189-212 1927294-1 1991 Catecholamines that are released in excess during human labor are inactivated mainly by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 88-116 1671550-1 1991 Rat liver ornithine decarboxylase induction by dexamethasone or laparatomy, which is dramatically impaired by catecholamine depletion, is not affected by alpha-and beta -adrenergic blockers administered simultaneously 1 h prior to steroid injection or operation. Catecholamines 110-123 ornithine decarboxylase 1 Rattus norvegicus 10-33 1833942-7 1991 That ANF-resistance may be related to the activation of the renin-angiotensin-aldosterone axis, increased circulating catecholamines, renal sympathetic nerve stimulation, changes in renal hemodynamics or increased degradation of ANF. Catecholamines 118-132 natriuretic peptide A Homo sapiens 5-8 1927294-1 1991 Catecholamines that are released in excess during human labor are inactivated mainly by catechol-O-methyltransferase (COMT). Catecholamines 0-14 catechol-O-methyltransferase Homo sapiens 118-122 1719750-5 1991 An increasing body of evidence indicates that IL-1, IFN-alpha, as well as C3a and C5a of the complement cascade, are capable of acting on central catecholamines within the brain. Catecholamines 146-160 interleukin 1 alpha Homo sapiens 46-50 1719750-5 1991 An increasing body of evidence indicates that IL-1, IFN-alpha, as well as C3a and C5a of the complement cascade, are capable of acting on central catecholamines within the brain. Catecholamines 146-160 interferon alpha 1 Homo sapiens 52-61 1719750-5 1991 An increasing body of evidence indicates that IL-1, IFN-alpha, as well as C3a and C5a of the complement cascade, are capable of acting on central catecholamines within the brain. Catecholamines 146-160 complement C5a receptor 1 Homo sapiens 82-85 1673911-2 1991 Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 67-80 tyrosine hydroxylase Homo sapiens 0-20 1664747-6 1991 Our data suggest that the increase in beta 2-adrenoceptors may be due to a compensatory phenomenon, owing to the reduced beta-adrenergic sensitivity observed in the elderly subjects; moreover, the regulation of beta-adrenoceptors by plasma catecholamines seems to be altered by aging. Catecholamines 240-254 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 38-44 1674668-1 1991 In the present study, we have evaluated the effect of both facilitatory beta 2-adrenoceptor and angiotensin II receptor on the release of adrenal catecholamines induced by electrical stimulation of the splanchnic nerve in anaesthetized and vagotomized dog. Catecholamines 146-160 beta-2 adrenergic receptor Canis lupus familiaris 72-91 1682049-1 1991 The presence of enzymes (tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (D beta H)) and enzymatic activities (monoamino oxidase, (MAO)) related to catecholamine synthesis and degradation have been investigated in cervical, thoracic and lumbar dorsal root ganglia (DRG) of adult male rats using immunohistochemical and enzyme histochemical techniques, respectively. Catecholamines 156-169 monoamine oxidase A Rattus norvegicus 139-142 2006996-9 1991 This enzyme differs from adrenal PNMT in substrate and inhibitor specificity and its activity is enhanced by catecholamine depletion and by glucocorticoid treatment. Catecholamines 109-122 phenylethanolamine-N-methyltransferase Rattus norvegicus 33-37 1673911-2 1991 Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 67-80 tyrosine hydroxylase Homo sapiens 22-24 1895567-1 1991 Interactions between gamma-aminobutyric acid (GABA)- and catecholamine (CA)-containing cells in the rat retina was revealed by a double-labeling immunocytochemical technique using the antisera to GABA- and CA-synthesizing enzymes, such as tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 57-70 phenylethanolamine-N-methyltransferase Rattus norvegicus 269-307 1664342-4 1991 Catecholamines seem to be more regulator than originator of the insulin secretory process. Catecholamines 0-14 insulin Homo sapiens 64-71 1937065-1 1991 A direct synapse between catecholamine fibers and neuropeptide Y-containing neurons is demonstrated in rat cerebral cortex using an immunohistochemical double-staining method under the electron microscope. Catecholamines 25-38 neuropeptide Y Rattus norvegicus 50-64 1817165-4 1991 Like the observations on adrenergic neurones, non-selective and selective MAO-A inhibitors potentiate the catecholamine-releasing property of tyramine in PC12 cells. Catecholamines 106-119 monoamine oxidase A Rattus norvegicus 74-79 1817165-8 1991 In the final analysis the inter-relationship between MAO-A activity and the presence of tyramine-releasable pool of catecholamines in adrenergic neurons and PC12 cells may have a genetic basis and could be important in illuminating the differentiation of neural crest into adrenergic neurones and adrenal medulla on the one hand and chromaffin cells to PC12 cells on the other. Catecholamines 116-130 monoamine oxidase A Rattus norvegicus 53-58 1680735-3 1991 Cocaine, a catecholamine agonist, has been shown to produce a transient induction of the immediate-early gene c-fos and its protein product Fos in the striatum of normal rats. Catecholamines 11-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 110-115 1680735-3 1991 Cocaine, a catecholamine agonist, has been shown to produce a transient induction of the immediate-early gene c-fos and its protein product Fos in the striatum of normal rats. Catecholamines 11-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 140-143 1680735-9 1991 The preferential expression of Fos in neurons of the P regions of the grafts thus implies that the induction of Fos was cell-type specific in being concentrated in the parts of the grafts that express striatal phenotype and that are innervated by catecholamine-containing fibers. Catecholamines 247-260 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-34 1680735-9 1991 The preferential expression of Fos in neurons of the P regions of the grafts thus implies that the induction of Fos was cell-type specific in being concentrated in the parts of the grafts that express striatal phenotype and that are innervated by catecholamine-containing fibers. Catecholamines 247-260 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 112-115 1725316-1 1991 Recently, we have observed that endothelin-1 (ET-1) evokes the release of catecholamines (CA) from adrenal chromaffin cells. Catecholamines 74-88 endothelin 1 Homo sapiens 32-44 1725316-1 1991 Recently, we have observed that endothelin-1 (ET-1) evokes the release of catecholamines (CA) from adrenal chromaffin cells. Catecholamines 74-88 endothelin 1 Homo sapiens 46-50 1895567-1 1991 Interactions between gamma-aminobutyric acid (GABA)- and catecholamine (CA)-containing cells in the rat retina was revealed by a double-labeling immunocytochemical technique using the antisera to GABA- and CA-synthesizing enzymes, such as tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT). Catecholamines 57-70 phenylethanolamine-N-methyltransferase Rattus norvegicus 309-313 1997793-5 1991 It is concluded that IL-1 beta affects the metabolism of catecholamines (and probably other neurotransmitters) in the brain, which, in turn, mediate its central and neuroendocrine actions. Catecholamines 57-71 interleukin 1 beta Rattus norvegicus 21-30 1648157-3 1991 Thus, alpha 2-adrenoceptor activation by circulating or neuronally released catecholamines inhibits the release of insulin from pancreatic islet beta-cells and, by inhibiting this response, alpha 2-adrenoceptor antagonists have been shown to have an antihyperglycemic effect. Catecholamines 76-90 insulin Homo sapiens 115-122 1654493-1 1991 To test the hypothesis that angiotensin II (Ang II) in the central nervous system modulates catecholamine-induced cardiac arrhythmias and to determine whether endogenous opioids are operative in this action, arrhythmias were produced in male Wistar rats, by continuous infusion of epinephrine at incremental doses until the development of fatal arrhythmias that were usually ventricular fibrillation. Catecholamines 92-105 angiotensinogen Rattus norvegicus 44-50 1988765-1 1991 Chromogranin A, co-stored and co-released with catecholamines from adrenal medullary and sympathetic neuronal vesicles, is elevated in the plasma of patients with pheochromocytoma. Catecholamines 47-61 chromogranin A Homo sapiens 0-14 1710791-6 1991 These data suggest that alpha 2u-globulin-induced changes in gonadotropin and prolactin secretion are mediated by changes in catecholamine metabolism in several hypothalamic regions. Catecholamines 125-138 alpha2u globulin Rattus norvegicus 24-41 1646411-2 1991 This hypothesis has been tested here by investigating the effect of the met-enkephalin analog, DAMME (FK-33,824), on the elevation in serum cortisol induced by the catecholamine-releasing agent d-amphetamine (10 and 25 mg p.o.) Catecholamines 164-177 proopiomelanocortin Homo sapiens 72-86 1813924-1 1991 Neuroendocrine and catecholamine dysfunctions in depression may be linked by corticotropin-releasing factor (CRF) effects on locus coeruleus (LC) neurons. Catecholamines 19-32 corticotropin releasing hormone Homo sapiens 77-107 2046887-0 1991 Neural modulation of lysine vasopressin-induced changes of catecholamines in the adrenal medulla of the pigeon. Catecholamines 59-73 arginine vasopressin Homo sapiens 28-39 2260723-1 1990 The present studies were designed to determine the fetal catecholamine and metabolic responses to insulin-induced maternal hypoglycemia. Catecholamines 57-70 insulin Homo sapiens 98-105 2175152-6 1990 The metabolism of catecholestrogens may be divided into reversible and irreversible reactions, of which the reaction with the catechol-O-methyltransferase, and thereby the interaction with catecholamines, the conjugation, and the thioether formation are the most prominent. Catecholamines 189-203 catechol-O-methyltransferase Homo sapiens 126-154 19912776-4 1990 The catecholamine uptake blocker desipramine and the alpha(2)-adrenergic receptor agonist clonidine inhibited accumulation of newly synthesized catecholamines, but only after prolonged exposure to drug; NPY synthesis and accumulation were unaltered by these treatments. Catecholamines 4-17 neuropeptide Y Rattus norvegicus 203-206 2076856-5 1990 It has been suggested that hyperinsulinism and insulin resistance may lead to hypertension through altered intracellular calcium metabolism, enhanced renal sodium reabsorption, or through an effect of insulin upon lipid and/or catecholamine metabolism. Catecholamines 227-240 insulin Homo sapiens 32-39 2076856-5 1990 It has been suggested that hyperinsulinism and insulin resistance may lead to hypertension through altered intracellular calcium metabolism, enhanced renal sodium reabsorption, or through an effect of insulin upon lipid and/or catecholamine metabolism. Catecholamines 227-240 insulin Homo sapiens 47-54 1977891-1 1990 The expression of the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), is confined to several different types of neuroendocrine cells. Catecholamines 22-35 tyrosine hydroxylase Homo sapiens 57-77 1977891-1 1990 The expression of the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), is confined to several different types of neuroendocrine cells. Catecholamines 22-35 tyrosine hydroxylase Homo sapiens 79-81 1700068-9 1990 Removal of SP after a desensitizing stimulation with SP + DMPP caused a slow secondary release of catecholamine in response to the continued stimulation with DMPP. Catecholamines 98-111 tachykinin precursor 1 Bos taurus 11-13 1700068-9 1990 Removal of SP after a desensitizing stimulation with SP + DMPP caused a slow secondary release of catecholamine in response to the continued stimulation with DMPP. Catecholamines 98-111 tachykinin precursor 1 Bos taurus 53-55 2173628-1 1990 Incubation of cardiac sarcolemma in the presence of dopamine beta-hydroxylase (DBH), a catecholamine biosynthetic enzyme, increased beta-adrenergic receptor density by 68% as measured by [3H]dihydroalprenolol (DHA) binding. Catecholamines 87-100 dopamine beta-hydroxylase Homo sapiens 52-77 1963557-7 1990 administration of BNP (0.2, 1 nmol/3 microliters) dose-dependently attenuated central ET (40 pmol/2 microliter)-induced pressor response, plasma catecholamine and ACTH secretion. Catecholamines 145-158 natriuretic peptide B Rattus norvegicus 18-21 1982693-5 1990 The possible roles of brain catecholamines on the behavioral effects of LHRH are analysed. Catecholamines 28-42 gonadotropin releasing hormone 1 Rattus norvegicus 72-76 2173628-1 1990 Incubation of cardiac sarcolemma in the presence of dopamine beta-hydroxylase (DBH), a catecholamine biosynthetic enzyme, increased beta-adrenergic receptor density by 68% as measured by [3H]dihydroalprenolol (DHA) binding. Catecholamines 87-100 dopamine beta-hydroxylase Homo sapiens 79-82 2280902-1 1990 Bradykinin (BK), a nonapeptide acting at the B2-type BK-receptor, and depolarization with high KCl (50 mM), induce catecholamine secretion in pheochromocytoma cells (PC-12). Catecholamines 115-128 kininogen 1 Homo sapiens 0-10 2171909-0 1990 The adrenocorticotropin response to interleukin-1 beta instilled into the rat median eminence depends on the local release of catecholamines. Catecholamines 126-140 interleukin 1 beta Rattus norvegicus 36-54 2280902-1 1990 Bradykinin (BK), a nonapeptide acting at the B2-type BK-receptor, and depolarization with high KCl (50 mM), induce catecholamine secretion in pheochromocytoma cells (PC-12). Catecholamines 115-128 kininogen 1 Homo sapiens 12-14 2223810-9 1990 Although chromaffin granule ghost-associated phospholipase A2 is most likely a lysosomal contaminant, its broad, biomembrane-modulated pH range may still allow it to participate in catecholamine secretion. Catecholamines 181-194 LOC104974671 Bos taurus 45-61 2078982-0 1990 EOG and ERG modifications induced in the chicken eye after blockade of catecholamine and 5-hydroxytryptamine biosynthesis. Catecholamines 71-84 ETS transcription factor ERG Gallus gallus 8-11 2240130-1 1990 The pulsatile release of gonadotropin-releasing hormone and the consequent secretion of gonadotropins are regulated by a complex interplay of steroids, neuropeptides, catecholamines, and environmental factors. Catecholamines 167-181 gonadotropin releasing hormone 1 Homo sapiens 25-55 2243344-14 1990 However, the DuP 753-sensitive site (AII-1) appears to mediate the AII-induced responses such as adrenal aldosterone and catecholamine secretion, release of catecholamine from sympathetic ganglia, drinking and vasoconstriction. Catecholamines 121-134 angiotensinogen Rattus norvegicus 37-40 1978729-1 1990 This study tests the hypothesis that atrial natriuretic factor (ANF) and C-ANF(4-23)-NH2 (C-ANF) augment cGMP generation and inhibit both cAMP generation and depolarization-induced catecholamine release in nerve growth factor treated pheochromocytoma cells by a pertussis toxin (PTX)-sensitive mechanism. Catecholamines 181-194 natriuretic peptide A Rattus norvegicus 37-62 1978729-1 1990 This study tests the hypothesis that atrial natriuretic factor (ANF) and C-ANF(4-23)-NH2 (C-ANF) augment cGMP generation and inhibit both cAMP generation and depolarization-induced catecholamine release in nerve growth factor treated pheochromocytoma cells by a pertussis toxin (PTX)-sensitive mechanism. Catecholamines 181-194 natriuretic peptide A Rattus norvegicus 64-67 1978729-1 1990 This study tests the hypothesis that atrial natriuretic factor (ANF) and C-ANF(4-23)-NH2 (C-ANF) augment cGMP generation and inhibit both cAMP generation and depolarization-induced catecholamine release in nerve growth factor treated pheochromocytoma cells by a pertussis toxin (PTX)-sensitive mechanism. Catecholamines 181-194 natriuretic peptide A Rattus norvegicus 75-78 1978729-1 1990 This study tests the hypothesis that atrial natriuretic factor (ANF) and C-ANF(4-23)-NH2 (C-ANF) augment cGMP generation and inhibit both cAMP generation and depolarization-induced catecholamine release in nerve growth factor treated pheochromocytoma cells by a pertussis toxin (PTX)-sensitive mechanism. Catecholamines 181-194 natriuretic peptide A Rattus norvegicus 75-78 1978729-4 1990 Both ANF (10(-11)-10(-9) M) and C-ANF (10(-11)-10(-8) M) also inhibited K(+)-induced catecholamine release in a concentration-dependent manner. Catecholamines 85-98 natriuretic peptide A Rattus norvegicus 5-8 1978729-4 1990 Both ANF (10(-11)-10(-9) M) and C-ANF (10(-11)-10(-8) M) also inhibited K(+)-induced catecholamine release in a concentration-dependent manner. Catecholamines 85-98 natriuretic peptide A Rattus norvegicus 34-37 1978729-7 1990 Therefore, PTX dissociated the increased concentrations of cGMP from the ANF-mediated depression of evoked catecholamine release. Catecholamines 107-120 natriuretic peptide A Rattus norvegicus 73-76 1978729-8 1990 C-ANF also dissociated elevations in cGMP concentrations from an ANF-mediated attenuation of evoked catecholamine release. Catecholamines 100-113 natriuretic peptide A Rattus norvegicus 2-5 1978729-8 1990 C-ANF also dissociated elevations in cGMP concentrations from an ANF-mediated attenuation of evoked catecholamine release. Catecholamines 100-113 natriuretic peptide A Rattus norvegicus 65-68 2243344-14 1990 However, the DuP 753-sensitive site (AII-1) appears to mediate the AII-induced responses such as adrenal aldosterone and catecholamine secretion, release of catecholamine from sympathetic ganglia, drinking and vasoconstriction. Catecholamines 121-134 angiotensinogen Rattus norvegicus 67-70 2243344-14 1990 However, the DuP 753-sensitive site (AII-1) appears to mediate the AII-induced responses such as adrenal aldosterone and catecholamine secretion, release of catecholamine from sympathetic ganglia, drinking and vasoconstriction. Catecholamines 157-170 angiotensinogen Rattus norvegicus 37-40 2126354-6 1990 The rise of catecholamines in the hypothalamus of 10-day-old female rats induced by COMT inhibition with tropolone (0.3 mg on postnatal days 5 and 7) was unable to masculinize developing neuroendocrine regions responsible for sexual cyclicity. Catecholamines 12-26 catechol-O-methyltransferase Rattus norvegicus 84-88 1979671-0 1990 The A11 catecholamine cell group: another origin of the dopaminergic innervation of the amygdala. Catecholamines 8-21 selectin L Rattus norvegicus 4-7 2171935-1 1990 The reaction of myeloperoxidase with biologically active polyhydroxyphenols (substituted catechols): catecholamine, norepinephrine and 2,4,5-trihydroxyphenylalanine [Phe(OH)3] were investigated by using the ESR spin-stabilization technique and rapid-scan spectrophometry in the millisecond time scale. Catecholamines 101-114 myeloperoxidase Homo sapiens 16-31 2171935-4 1990 The first evidence of o-semiquinone radical formation as a product of the enzymatic oxidation of catecholamine by myeloperoxidase is reported. Catecholamines 97-110 myeloperoxidase Homo sapiens 114-129 2226440-1 1990 Catecholamines (adrenaline, noradrenaline and dopamine) are potent inhibitors of phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1). Catecholamines 0-14 phenylalanine hydroxylase Rattus norvegicus 112-137 2226440-9 1990 The high-affinity of catecholamines to phenylalanine hydroxylase is a valuable probe to study the active site of this enzyme and is also relevant for the homologous enzyme tyrosine hydroxylase, which is purified as a stable catecholamine-Fe(III) complex. Catecholamines 21-35 phenylalanine hydroxylase Rattus norvegicus 39-64 2097576-4 1990 These results may indicate a biological role for the putative PEC-60-like peptide demonstrated within central catecholamine cardiovascular neurons. Catecholamines 110-123 serine peptidase inhibitor, Kazal type 4 Rattus norvegicus 62-68 2253318-4 1990 Both the hemodynamic and plasma catecholamine alterations induced with PAF were completely blocked with WEB 2086 pretreatment. Catecholamines 32-45 PCNA clamp associated factor Rattus norvegicus 71-74 1977390-12 1990 As a working hypothesis it is proposed that Ca2(+)-mediated processes induced by catecholamines are involved in ODC gene expression during the prereplicative phase of liver regeneration. Catecholamines 81-95 ornithine decarboxylase 1 Rattus norvegicus 112-115 2175252-9 1990 ACTH-like peptide in the brain may act as a neuromodulator, mainly in the NLT and the preoptic nucleus, and around the nuclei of the ventricular recesses containing serotonin and catecholamines. Catecholamines 179-193 proopiomelanocortin Homo sapiens 0-4 2171366-3 1990 Histochemical studies revealed the presence of acetylcholinesterase activity associated with neuronal cell bodies and fibers, catecholamine-containing, small intensely fluorescent cells, and cell bodies and nerve fibers immunoreactive for vasoactive intestinal polypeptide. Catecholamines 126-139 acetylcholinesterase Rattus norvegicus 47-67 2282071-1 1990 Insulin receptor activity and its relationship with catecholamines and serotonin were investigated in rat whole brain membranes, synaptosomes and choroid plexus in alloxan induced short term and long term hyperglycemia and hyperinsulinemia. Catecholamines 52-66 insulin receptor Rattus norvegicus 0-16 2282071-2 1990 Insulin receptor activity was measured by [125I]insulin binding and catecholamines by high performance liquid chromatography with electrochemical detection. Catecholamines 68-82 insulin receptor Rattus norvegicus 0-16 2169395-3 1990 Therefore, these studies investigated the role of catecholamines in nicotine-stimulated ACTH secretion. Catecholamines 50-64 proopiomelanocortin Homo sapiens 88-92 1981788-5 1990 Compared to naive PC12 cells, K-ras infected PC12 cells had (a) higher activities of acetylcholinesterase and choline acetyltransferase, two enzymes involved in acetylcholine metabolism; (b) enhanced activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis; (c) a higher, evoked norepinephrine release; and (d) similar levels of sodium-dependent uptake of both choline and norepinephrine. Catecholamines 262-275 KRAS proto-oncogene, GTPase Rattus norvegicus 30-35 1981788-6 1990 Although the total content of catecholamines in K-ras-differentiated PC12 cells was less than that of naive cells, both norepinephrine and dopamine were present in substantial amounts and norepinephrine was released after stimulation. Catecholamines 30-44 KRAS proto-oncogene, GTPase Rattus norvegicus 48-53 2262866-6 1990 However, the amounts of catecholamine metabolites were low in the cases with amplification, and this suggests immaturity of catecholamine metabolism in the tumor with N-myc gene amplification. Catecholamines 24-37 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 167-172 2204682-4 1990 The selective presence of PST in the neurons of the CNS raises the issue as to the role of this enzyme in sulfating neurotransmitters because PST has been shown to be capable of conjugating a variety of neurotransmitters including the catecholamines as well as the tyrosine moiety of a number of small peptides such as enkephalin and cholecystokinin. Catecholamines 235-249 sulfotransferase family 1A member 1 Homo sapiens 26-29 2204682-4 1990 The selective presence of PST in the neurons of the CNS raises the issue as to the role of this enzyme in sulfating neurotransmitters because PST has been shown to be capable of conjugating a variety of neurotransmitters including the catecholamines as well as the tyrosine moiety of a number of small peptides such as enkephalin and cholecystokinin. Catecholamines 235-249 sulfotransferase family 1A member 1 Homo sapiens 142-145 1982150-6 1990 The increase in mean blood pressure in urethane-anaesthetized rats after clenbuterol treatment may be a consequence of a reduced vasodilator beta 2-adrenoceptor-mediated response to circulating catecholamines. Catecholamines 194-208 adrenoceptor beta 2 Rattus norvegicus 141-160 2262866-6 1990 However, the amounts of catecholamine metabolites were low in the cases with amplification, and this suggests immaturity of catecholamine metabolism in the tumor with N-myc gene amplification. Catecholamines 124-137 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 167-172 2276081-1 1990 The present study was carried out to determine whether an increase in the pancreatic immunoreactive glucagon (IRG) secretion during the acute phase of insulin-induced hypoglycemia depends on circulating catecholamines of adrenal origin. Catecholamines 203-217 insulin Canis lupus familiaris 151-158 1980840-1 1990 We have examined the soma diameters and distribution of catecholaminergic (CA) cells in human retinae, by using an antibody to tyrosine hydroxylase (TH), the rate limiting enzyme in the production of catecholamines. Catecholamines 200-214 tyrosine hydroxylase Homo sapiens 127-147 1978793-3 1990 In these cells, prolactin inhibited the activity of tyrosine hydroxylase, the rate-limiting enzyme in the catecholamine synthesis, in a dose-dependent manner, from a concentration above 50 ng/ml of prolactin in the incubation medium. Catecholamines 106-119 prolactin Bos taurus 16-25 1978793-3 1990 In these cells, prolactin inhibited the activity of tyrosine hydroxylase, the rate-limiting enzyme in the catecholamine synthesis, in a dose-dependent manner, from a concentration above 50 ng/ml of prolactin in the incubation medium. Catecholamines 106-119 prolactin Bos taurus 198-207 1978796-2 1990 Tyrosine hydroxylase (TH)-immunofluorescent neurons which collateralize to the PAG and the cervical spinal cord were found in all brainstem catecholamine cell groups previously shown to contain neurons which project to the spinal cord, including the A5 and A7 cell groups, locus coeruleus, subcoeruleus and the C1 cell group. Catecholamines 140-153 tyrosine hydroxylase Rattus norvegicus 0-20 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 102-127 2126661-1 1990 Neuropeptide Y is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. Catecholamines 105-119 neuropeptide Y Rattus norvegicus 0-14 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 dopamine beta-hydroxylase Rattus norvegicus 129-132 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 phenylethanolamine-N-methyltransferase Rattus norvegicus 139-177 1976532-1 1990 Immunohistochemical localization of the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and phenylethanolamine N-methyltransferase (PNMT) was employed to reveal the anatomical organization of the A1 noradrenergic cell group in the caudal ventrolateral medulla oblongata of the rat. Catecholamines 40-53 phenylethanolamine-N-methyltransferase Rattus norvegicus 179-183 1704616-7 1990 In light of other pharmacological and anatomical evidence, it is suggested the PVN GAL, in modulating feeding behavior, may work in association with the catecholamine norepinephrine (NE) which is known to coexist with GAL in PVN neurons. Catecholamines 153-166 galanin and GMAP prepropeptide Rattus norvegicus 83-86 1975839-2 1990 Also, the activity of these neurons at least partially reflects their content of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Catecholamines 136-149 tyrosine hydroxylase Rattus norvegicus 81-101 1983139-0 1990 Plasma gastrin and somatostatin in newborn infants and their relationship to catecholamines. Catecholamines 77-91 gastrin Homo sapiens 7-14 1983139-0 1990 Plasma gastrin and somatostatin in newborn infants and their relationship to catecholamines. Catecholamines 77-91 somatostatin Homo sapiens 19-31 2233752-1 1990 Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Catecholamines 48-62 lipoprotein lipase Rattus norvegicus 0-18 2233752-1 1990 Lipoprotein lipase (LPL) is highly regulated by catecholamines and insulin in adipocytes. Catecholamines 48-62 lipoprotein lipase Rattus norvegicus 20-23 1704616-7 1990 In light of other pharmacological and anatomical evidence, it is suggested the PVN GAL, in modulating feeding behavior, may work in association with the catecholamine norepinephrine (NE) which is known to coexist with GAL in PVN neurons. Catecholamines 153-166 galanin and GMAP prepropeptide Rattus norvegicus 218-221 2283382-5 1990 After switching columns, the fluorescent derivatized catecholamines were separated with an ODS-4PW column (TSK) and a mobile phase of pH 2 and the fluorescence was monitored with excitation at 340 and emission at 440 nm. Catecholamines 53-67 tsukushi, small leucine rich proteoglycan Homo sapiens 107-110 2117669-2 1990 To do this, we have employed volume expansion, nursed patients in the flat position, and actively used catecholamine infusions to maintain the SABP side of the CPP equation at levels necessary to obtain the target CPP. Catecholamines 103-116 prolactin induced protein Homo sapiens 143-147 2243613-0 1990 Neural influence on the action of insulin in the adrenomedullary catecholamine content in the pigeon. Catecholamines 65-78 insulin Homo sapiens 34-41 2164894-2 1990 Two genetically and pharmacologically distinct receptors, beta 1 and beta 2, mediate the contractile effects of catecholamines in a similar manner. Catecholamines 112-126 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 58-75 2197024-2 1990 In particular, catecholamines may selectively improve diastolic function by reducing myofilament calcium sensitivity, accelerating sequestration of calcium into the sarcoplasmic reticulum, and increasing the rate of actin-myosin cross-bridge turnover. Catecholamines 15-29 myosin heavy chain 14 Homo sapiens 222-228 2204497-0 1990 Dopamine beta-hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues. Catecholamines 83-96 dopamine beta-hydroxylase Rattus norvegicus 0-25 1974641-8 1990 The same catecholamine oxidation product, characterized as the GSH adduct, could be generated by a xanthine-xanthine oxidase mixture and by tyrosinase. Catecholamines 9-22 tyrosinase Rattus norvegicus 140-150 2117444-0 1990 Stimulation of Ca2(+)-independent catecholamine secretion from digitonin-permeabilized bovine adrenal chromaffin cells by guanine nucleotide analogues. Catecholamines 34-47 carbonic anhydrase 2 Bos taurus 15-18 2165599-6 1990 Rab3A was specifically expressed in the catecholamine-secreting chromaffin cells. Catecholamines 40-53 RAB3A, member RAS oncogene family Bos taurus 0-5 2165599-7 1990 Subcellular fractionation suggested that Rab3A is about 30% cytosolic and that particulate Rab3A is associated with the membrane of chromaffin granules (the catecholamine storage organelles) and with a second compartment likely to be the plasma membrane. Catecholamines 157-170 RAB3A, member RAS oncogene family Bos taurus 91-96 1976030-1 1990 Previous studies have shown that preganglionic nerve stimulation in vitro increases acutely the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, in sympathetic neuronal cell bodies in the rat superior cervical ganglion (SCG). Catecholamines 163-176 tyrosine hydroxylase Rattus norvegicus 108-128 1976030-1 1990 Previous studies have shown that preganglionic nerve stimulation in vitro increases acutely the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, in sympathetic neuronal cell bodies in the rat superior cervical ganglion (SCG). Catecholamines 163-176 tyrosine hydroxylase Rattus norvegicus 130-132 2117444-7 1990 Arachidonic acid (100 microM) also stimulated Ca2(+)-independent catecholamine secretion. Catecholamines 65-78 carbonic anhydrase 2 Bos taurus 46-49 1697664-3 1990 These results suggest the existence of ANG II/NA and ANG II/A costoring neurons in the A1 and C1 group, respectively, opening new possibilities for ANG II-catecholamine interactions in cardiovascular and neuroendocrine regulation. Catecholamines 155-168 angiotensinogen Rattus norvegicus 39-45 2364381-5 1990 Catecholamines are increased after TNF administration, but alpha- and beta-adrenergic blockade did not prevent the lipogenic effects of TNF. Catecholamines 0-14 tumor necrosis factor-like Rattus norvegicus 35-38 2171719-4 1990 Differences in NAT into cortical and hypothalamic synaptosomes were also observed with noradrenaline itself (Km = 39.5 +/- 7.5 nM and 100 +/- 12.1 nM, respectively) and with the catecholamine uptake blocker mazindol (Ki = 0.55 +/- 0.05 nM and 0.30 +/- 0.08 nM, respectively). Catecholamines 178-191 N-acetyltransferase 1 Rattus norvegicus 15-18 1697664-3 1990 These results suggest the existence of ANG II/NA and ANG II/A costoring neurons in the A1 and C1 group, respectively, opening new possibilities for ANG II-catecholamine interactions in cardiovascular and neuroendocrine regulation. Catecholamines 155-168 angiotensinogen Rattus norvegicus 53-59 1697664-3 1990 These results suggest the existence of ANG II/NA and ANG II/A costoring neurons in the A1 and C1 group, respectively, opening new possibilities for ANG II-catecholamine interactions in cardiovascular and neuroendocrine regulation. Catecholamines 155-168 angiotensinogen Rattus norvegicus 53-59 2195410-0 1990 Opioid, catecholamine, and steroid interaction in prolactin and gonadotropin regulation. Catecholamines 8-21 prolactin Homo sapiens 50-59 2118962-0 1990 Nerve growth factor and K-252a increase catecholamine release from PC12 cells. Catecholamines 40-53 nerve growth factor Rattus norvegicus 0-19 2232318-8 1990 Plasma catecholamine levels also increased (Adr 0.01-0.10 ng/ml, Ndr 0.05-0.22 ng/ml). Catecholamines 7-20 serine/threonine kinase 38 Homo sapiens 65-68 2353937-10 1990 The accumulation of MIBG in SK-N-SH cells, reflecting "pure" Uptake-1, appears to be a powerful system for exploring various cellular and molecular aspects of catecholamine uptake. Catecholamines 159-172 hedgehog acyltransferase Homo sapiens 28-32 1698509-4 1990 Further, experimentation with the catecholamine synthesis inhibitors, alpha-methyl-p-tyrosine and Fla-63, suggested that GAL"s action also depends upon the release of endogenous NE. Catecholamines 34-47 galanin and GMAP prepropeptide Homo sapiens 121-124 1698509-6 1990 Neuropeptide Y remains effective in eliciting feeding in the presence of alpha 2-receptor antagonists and catecholamine-synthesis inhibitors, suggesting that, unlike GAL, it can act independently of endogenous NE. Catecholamines 106-119 neuropeptide Y Homo sapiens 0-14 1975832-11 1990 It is well known that catecholamine, especially noradrenaline has an inhibiting action on insulin secretion from beta cell. Catecholamines 22-35 insulin Homo sapiens 90-97 1975832-14 1990 We think an inhibiting action on insulin secretion of catecholamine was diminished through its action as adrenoceptor antagonist. Catecholamines 54-67 insulin Homo sapiens 33-40 1971535-0 1990 Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium. Catecholamines 91-105 adrenoceptor beta 1 Homo sapiens 10-29 2189303-1 1990 PURPOSE: Chromogranin A, co-released with catecholamines from the adrenal medullary and sympathetic neuronal vesicles, is elevated in plasma from patients with pheochromocytoma. Catecholamines 42-56 chromogranin A Homo sapiens 9-23 2203383-2 1990 It is possible that these factors may play a role in changes in insulin sensitivity in vivo produced by such diverse conditions as treatment with furosemide, thyroid status or catecholamine status. Catecholamines 176-189 insulin Homo sapiens 64-71 2203383-3 1990 In particular, there is evidence that chronic elevation of catecholamine or sympathetic stimulation improves insulin sensitivity. Catecholamines 59-72 insulin Homo sapiens 109-116 2203383-5 1990 Consequently, insulin resistance and decreased thermogenesis may be explained by decreased levels of catecholamines and/or a decreased sensitivity of skeletal muscle and perhaps other tissues to catecholamines or a decreased activity of the sympathetic nervous system. Catecholamines 101-115 insulin Homo sapiens 14-21 2203383-5 1990 Consequently, insulin resistance and decreased thermogenesis may be explained by decreased levels of catecholamines and/or a decreased sensitivity of skeletal muscle and perhaps other tissues to catecholamines or a decreased activity of the sympathetic nervous system. Catecholamines 195-209 insulin Homo sapiens 14-21 1971535-0 1990 Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium. Catecholamines 91-105 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 123-129 1971535-1 1990 We determined the relative contribution of beta 1- and beta 2-adrenoceptor stimulation to the positive inotropic responses of human atrial myocardium to catecholamines. Catecholamines 153-167 adrenoceptor beta 1 Homo sapiens 43-74 2172554-0 1990 Cooperative action of insulin and catecholamines on stimulation of ornithine decarboxylase activity in neonatal rat heart cells. Catecholamines 34-48 ornithine decarboxylase 1 Rattus norvegicus 67-90 2172554-4 1990 Co-administration of serum and catecholamines at 10(-5) M induced an ODC response that was significantly greater than that induced by serum alone. Catecholamines 31-45 ornithine decarboxylase 1 Rattus norvegicus 69-72 2172554-5 1990 A screen of various constituents of serum revealed that insulin, though relatively ineffective alone, acted cooperatively with catecholamines to produce an ODC response equivalent to that induced by 10% serum. Catecholamines 127-141 ornithine decarboxylase 1 Rattus norvegicus 156-159 2338548-6 1990 Recently it has been demonstrated in human brain that neurons in regions rich in catecholamines are positive for MAO-A. Catecholamines 81-95 monoamine oxidase A Homo sapiens 113-118 2172554-6 1990 Propranolol effectively blocked the cooperative effect of insulin on catecholamine stimulation of ODC activity, and markedly inhibited the stimulation of ODC by 10% serum. Catecholamines 69-82 ornithine decarboxylase 1 Rattus norvegicus 98-101 2109687-8 1990 Reports of the colocalization of NPY and catecholamines in the same axon terminals raises the possibility of a potential interaction between NPY and catecholamines to influence TRH neurons in the PVN. Catecholamines 41-55 neuropeptide Y Rattus norvegicus 141-144 1694105-9 1990 The catecholamine-synthesizing enzyme TH, however, which has a cytoplasmic localization and is not released from nerve endings, remains high in the cell bodies and nerve endings during this state of increased activity. Catecholamines 4-17 tyrosine hydroxylase Rattus norvegicus 38-40 1972655-4 1990 Tyrosine hydroxylase immunohistochemistry revealed that new catecholamine fibers of central nervous origin extended only into the periphery and not into the core of transplants grafted within the cortex. Catecholamines 60-73 tyrosine hydroxylase Rattus norvegicus 0-20 2328841-5 1990 In addition, MANS as well as CNTF and CDF decreased catecholamine synthesis. Catecholamines 52-65 ciliary neurotrophic factor Homo sapiens 29-33 2328841-5 1990 In addition, MANS as well as CNTF and CDF decreased catecholamine synthesis. Catecholamines 52-65 LIF interleukin 6 family cytokine Homo sapiens 38-41 2170629-15 1990 Vasoactive intestinal polypeptide (VIP) and muscarine induced catecholamine secretion from the perfused adrenal medulla via formation of inositol-1,4,5-tirisphosphate (IP3). Catecholamines 62-75 vasoactive intestinal peptide Rattus norvegicus 0-33 2170629-15 1990 Vasoactive intestinal polypeptide (VIP) and muscarine induced catecholamine secretion from the perfused adrenal medulla via formation of inositol-1,4,5-tirisphosphate (IP3). Catecholamines 62-75 vasoactive intestinal peptide Rattus norvegicus 35-38 1975102-3 1990 The tyrosine hydroxylase gene encodes the rate-limiting enzyme in the synthesis of catecholamines and might be a candidate for causing the manic-depressive phenotype. Catecholamines 83-97 tyrosine hydroxylase Homo sapiens 4-24 2159229-2 1990 Catecholamines stimulated lipolysis in an affinity sequence typical of the beta 1-adrenoceptor subtype: one-half maximum velocity (1/2 Vmax) isoproterenol (35 nM) much greater than 1/2 Vmax norepinephrine (150 nM) approximately 1/2 Vmax epinephrine (200 nM). Catecholamines 0-14 adrenoceptor beta 1 Rattus norvegicus 75-94 1972647-3 1990 A neuromodulatory interaction that has been linked to memory function and which has been the subject of biochemical inquiry is the interaction between the catecholamine, norepinephrine (NE) and the neuropeptide, vasopressin (AVP). Catecholamines 155-168 arginine vasopressin Homo sapiens 212-223 2331903-0 1990 Platelet and plasma catecholamines in relation to plasma minerals and parathyroid hormone following acute myocardial infarction. Catecholamines 20-34 parathyroid hormone Homo sapiens 70-89 1970290-1 1990 Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. Catecholamines 111-125 neuropeptide Y Rattus norvegicus 0-14 1970290-1 1990 Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. Catecholamines 111-125 neuropeptide Y Rattus norvegicus 16-19 2109687-8 1990 Reports of the colocalization of NPY and catecholamines in the same axon terminals raises the possibility of a potential interaction between NPY and catecholamines to influence TRH neurons in the PVN. Catecholamines 149-163 neuropeptide Y Rattus norvegicus 33-36 2332506-2 1990 Chromogranin A is an acidic protein costored and coreleased with catecholamines from storage vesicles. Catecholamines 65-79 chromogranin A Homo sapiens 0-14 2322933-5 1990 Based on these observations and the fact that neuroblastoma is not innervated in vivo, we hypothesize that in this tumor VIP is responsible for Ca2(+)-dependent release of catecholamines in an autocrine or paracrine fashion. Catecholamines 172-186 vasoactive intestinal peptide Homo sapiens 121-124 2380503-11 1990 These results suggested that adrenal NPY seemed to be coregulated with catecholamine, while VIP was mainly affected by histaminergic control. Catecholamines 71-84 neuropeptide Y Rattus norvegicus 37-40 2195784-7 1990 These observations suggest that endogenous insulin secretion is suppressed by increase plasma catecholamines, and that excessive rebound secretion of insulin after removal of a pheochromocytoma is a rather common phenomenon. Catecholamines 94-108 insulin Homo sapiens 43-50 2322933-1 1990 Release of catecholamines, a Ca2(+)-dependent process, is the most useful biochemical marker in the diagnosis of neuroblastoma. Catecholamines 11-25 carbonic anhydrase 2 Homo sapiens 29-32 1971451-1 1990 The patterns of colocalization of somatostatin (SOM), neuropeptide Y (NPY) and the catecholamine-synthesizing enzyme, dopamine beta-hydroxylase (DBH), were examined in intramural neurones in dissociated cell culture preparations from the detrusor muscle of the urinary bladder of the newborn guinea-pig using an elution-restaining immunocytochemical technique. Catecholamines 83-96 dopamine beta-hydroxylase Cavia porcellus 118-143 2322933-5 1990 Based on these observations and the fact that neuroblastoma is not innervated in vivo, we hypothesize that in this tumor VIP is responsible for Ca2(+)-dependent release of catecholamines in an autocrine or paracrine fashion. Catecholamines 172-186 carbonic anhydrase 2 Homo sapiens 144-147 1971451-1 1990 The patterns of colocalization of somatostatin (SOM), neuropeptide Y (NPY) and the catecholamine-synthesizing enzyme, dopamine beta-hydroxylase (DBH), were examined in intramural neurones in dissociated cell culture preparations from the detrusor muscle of the urinary bladder of the newborn guinea-pig using an elution-restaining immunocytochemical technique. Catecholamines 83-96 dopamine beta-hydroxylase Cavia porcellus 145-148 1972039-1 1990 Using specific antiserum against tyrosine hydroxylase, the key enzyme in catecholamine synthesis, we found tyrosine hydroxylase immunoreactive neurons (TH-IN) in the cerebral cortex of Swiss Webster mice. Catecholamines 73-86 tyrosine hydroxylase Mus musculus 33-53 2113409-10 1990 These findings suggest that TRH may act on sympathetic preganglionic neurons at the T7-10 spinal levels and stimulate the release of catecholamines from the adrenal medulla. Catecholamines 133-147 thyrotropin releasing hormone Rattus norvegicus 28-31 1969407-14 1990 The association of TH with granule membranes may play a role in coordinating TH activity and catecholamine release. Catecholamines 93-106 tyrosine hydroxylase Bos taurus 19-21 2354362-7 1990 These results suggest that phenylethanolamine N-methyltransferase (PNMT)-containing terminals in the rat spinal cord can synthesize epinephrine, but that little if any epinephrine is stored in synaptic vesicles due to the rapid metabolism of cytoplasmic catecholamines by monoamine oxidase. Catecholamines 254-268 phenylethanolamine-N-methyltransferase Rattus norvegicus 27-65 2354362-7 1990 These results suggest that phenylethanolamine N-methyltransferase (PNMT)-containing terminals in the rat spinal cord can synthesize epinephrine, but that little if any epinephrine is stored in synaptic vesicles due to the rapid metabolism of cytoplasmic catecholamines by monoamine oxidase. Catecholamines 254-268 phenylethanolamine-N-methyltransferase Rattus norvegicus 67-71 2192764-0 1990 Chronic and endogenous regulation of insulin receptors by catecholamines in adipocytes from patients with a phaeochromocytoma. Catecholamines 58-72 insulin Homo sapiens 37-44 2192764-5 1990 This was accompanied by a catecholamine-desensitization of the adipocytes to the antilipolytic action of insulin. Catecholamines 26-39 insulin Homo sapiens 105-112 2192764-6 1990 These events could represent a final situation of a chronic and endogenous regulation by high levels of catecholamines of insulin receptors in human adipose tissue. Catecholamines 104-118 insulin Homo sapiens 122-129 2170177-0 1990 [The effect of angiotensin II on the catecholamine content of the blood plasma in rats]. Catecholamines 37-50 angiotensinogen Rattus norvegicus 15-29 2317504-5 1990 It is concluded that catecholamine regulates the female rat liver regeneration through both alpha- and beta-adrenergic pathways by the inductions of thymidylate synthase and thymidine kinase, while in adult male and ovariectomized female rats, only the alpha-mediated pathway is involved. Catecholamines 21-34 thymidylate synthetase Rattus norvegicus 149-169 1972929-2 1990 The TH gene encodes the initial and rate-limiting enzyme of the catecholamine biosynthetic pathway. Catecholamines 64-77 tyrosine hydroxylase Rattus norvegicus 4-6 1970616-1 1990 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a 5-HT1A receptor-selective agonist that has recently been reported to trigger adrenal catecholamine release and hyperglycemia. Catecholamines 141-154 5-hydroxytryptamine receptor 1A Rattus norvegicus 56-62 2402098-6 1990 2) As for the enzymes of catecholamine biosynthesis, tyrosine hydroxylase (TyrOHase) activity was increased in the hypothalamus (p less than 0.05) and was reduced in the ME (p less than 0.01). Catecholamines 25-38 tyrosine hydroxylase Rattus norvegicus 53-73 2402098-6 1990 2) As for the enzymes of catecholamine biosynthesis, tyrosine hydroxylase (TyrOHase) activity was increased in the hypothalamus (p less than 0.05) and was reduced in the ME (p less than 0.01). Catecholamines 25-38 tyrosine hydroxylase Rattus norvegicus 75-83 1970788-0 1990 pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40. Catecholamines 24-38 tyrosine hydroxylase Bos taurus 44-64 2336195-3 1990 On retrograde perfusion of isolated bovine adrenal gland, release of VIP with catecholamine (CA) was marked on stimulation with high K+, but slight on stimulation with acetylcholine, which induced marked release of CA. Catecholamines 78-91 vasoactive intestinal peptide Bos taurus 69-72 2322238-0 1990 The influence of angiotensin II on catecholamine synthesis in neuronal cultures from rat brain. Catecholamines 35-48 angiotensinogen Rattus norvegicus 17-31 2322238-1 1990 Incubation of primary neuronal cultures prepared from the hypothalamus and brainstem of neonatal rats with angiotensin II (Ang-II) resulted in a concentration-dependent effect on the incorporation of [3H]-tyrosine ([3H]-Tyr) into [3H]-catecholamines ([3H]-CA). Catecholamines 235-249 angiotensinogen Rattus norvegicus 107-121 2322238-1 1990 Incubation of primary neuronal cultures prepared from the hypothalamus and brainstem of neonatal rats with angiotensin II (Ang-II) resulted in a concentration-dependent effect on the incorporation of [3H]-tyrosine ([3H]-Tyr) into [3H]-catecholamines ([3H]-CA). Catecholamines 235-249 angiotensinogen Rattus norvegicus 123-129 1970506-6 1990 Decreases in cellular catecholamine contents were accompanied by increases in TH and pEK mRNA levels, while the expression of PNMT gene exhibited a transient 4-fold increase and then profound inhibition (60-95%) over a 48-h period. Catecholamines 22-35 tyrosine hydroxylase Bos taurus 78-80 1968464-2 1990 The purpose of this study was to examine the effects of angiotensin on the enzyme activities and gene expression of two catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT), in bovine adrenal medullary (AM) cells. Catecholamines 120-133 tyrosine hydroxylase Bos taurus 156-176 1968464-2 1990 The purpose of this study was to examine the effects of angiotensin on the enzyme activities and gene expression of two catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT), in bovine adrenal medullary (AM) cells. Catecholamines 120-133 tyrosine hydroxylase Bos taurus 178-180 1968464-2 1990 The purpose of this study was to examine the effects of angiotensin on the enzyme activities and gene expression of two catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT), in bovine adrenal medullary (AM) cells. Catecholamines 120-133 phenylethanolamine N-methyltransferase Bos taurus 186-224 1968464-2 1990 The purpose of this study was to examine the effects of angiotensin on the enzyme activities and gene expression of two catecholamine synthesizing enzymes, tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT), in bovine adrenal medullary (AM) cells. Catecholamines 120-133 phenylethanolamine N-methyltransferase Bos taurus 226-230 1970506-6 1990 Decreases in cellular catecholamine contents were accompanied by increases in TH and pEK mRNA levels, while the expression of PNMT gene exhibited a transient 4-fold increase and then profound inhibition (60-95%) over a 48-h period. Catecholamines 22-35 proenkephalin Bos taurus 85-88 1970506-13 1990 Taken together, these results indicate that (1) the level of TH, PNMT, and pEK mRNAs are regulated by direct neural (acetylcholine) and hormonal (glucocorticoid) inputs to adrenal medullary cells; (2) effects of acetylcholine could be mediated by cyclic AMP and alterations in catecholamine content; and (3) expression of individual genes is regulated differentially. Catecholamines 277-290 tyrosine hydroxylase Bos taurus 61-63 1970506-13 1990 Taken together, these results indicate that (1) the level of TH, PNMT, and pEK mRNAs are regulated by direct neural (acetylcholine) and hormonal (glucocorticoid) inputs to adrenal medullary cells; (2) effects of acetylcholine could be mediated by cyclic AMP and alterations in catecholamine content; and (3) expression of individual genes is regulated differentially. Catecholamines 277-290 phenylethanolamine N-methyltransferase Bos taurus 65-69 19189710-5 1990 Immunohistochemistry showed tyrosine hydroxylase (TH) to be present in the same cells and the same strata of the inner plexiform layer as the endogenous catecholamines. Catecholamines 153-167 LOC100008895 Oryctolagus cuniculus 28-48 19189710-5 1990 Immunohistochemistry showed tyrosine hydroxylase (TH) to be present in the same cells and the same strata of the inner plexiform layer as the endogenous catecholamines. Catecholamines 153-167 LOC100008895 Oryctolagus cuniculus 50-52 1970506-13 1990 Taken together, these results indicate that (1) the level of TH, PNMT, and pEK mRNAs are regulated by direct neural (acetylcholine) and hormonal (glucocorticoid) inputs to adrenal medullary cells; (2) effects of acetylcholine could be mediated by cyclic AMP and alterations in catecholamine content; and (3) expression of individual genes is regulated differentially. Catecholamines 277-290 proenkephalin Bos taurus 75-78 1689379-0 1990 Studies on the effect of insulin-like growth factor-I on catecholamine secretion from chromaffin cells. Catecholamines 57-70 insulin like growth factor 1 Homo sapiens 25-53 1968697-1 1990 To study the physiologic role of human myocardial beta-2 adrenoceptors, the beta adrenoceptor subtype(s) involved in the effects of catecholamines in vitro on the force of contraction and in vivo on heart rate were characterized. Catecholamines 132-146 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 50-56 2346532-1 1990 Catecholamine metabolism was assessed in 14 patients with chronic congestive heart failure (NYHA class IV; cardiac index 2.4 +/- 0.2 l min-1, ejection fraction 20 +/- 11%) on levodopa (L-Dopa-ratiopharm) treatment: 1. prior to the start of levodopa treatment; 2. following acute administration of levodopa in the 14 patients and in 4 healthy control subjects; 3. after 30 days +/- 1 day with 2-4 g levodopa p.o. Catecholamines 0-13 CD59 molecule (CD59 blood group) Homo sapiens 135-140 2325882-2 1990 Treatment of chromaffin cells with IAP resulted in an increase in both basal release of catecholamine and evoked-release by either acetylcholine (ACh) or high K+. Catecholamines 88-101 intestinal-type alkaline phosphatase Bos taurus 35-38 2184065-0 1990 The activity of the renin-angiotensin-aldosterone system before and during submaximal bicycle exercise in relation to circulatory catecholamines in patients with type 1 (insulin-dependent) diabetes mellitus. Catecholamines 130-144 renin Homo sapiens 20-25 1689379-2 1990 Addition of insulin-like growth factor-I (IGF-I) to serum-free medium restored high K(+)-stimulated catecholamine secretion to the levels seen in serum-treated cultures. Catecholamines 100-113 insulin like growth factor 1 Homo sapiens 12-40 1689379-2 1990 Addition of insulin-like growth factor-I (IGF-I) to serum-free medium restored high K(+)-stimulated catecholamine secretion to the levels seen in serum-treated cultures. Catecholamines 100-113 insulin like growth factor 1 Homo sapiens 42-47 1689379-5 1990 IGF-I not only enhanced high K(+)-stimulated catecholamine secretion, but also augmented secretion elicited by the nicotinic agonist dimethyl-phenylpiperazinium, the dihydropyridine agonist Bay K 8644, and Ba2+. Catecholamines 45-58 insulin like growth factor 1 Homo sapiens 0-5 2138208-0 1990 Gamma 2-MSH in congestive heart failure: relation to atrial natriuretic peptide, arginine vasopressin and catecholamines. Catecholamines 106-120 proopiomelanocortin Homo sapiens 8-11 1689379-8 1990 When cells were permeabilized by treatment with digitonin, Ca2(+)-dependent catecholamine secretion was slightly, but consistently, greater from IGF-I-treated cells than from untreated cells. Catecholamines 76-89 carbonic anhydrase 2 Homo sapiens 59-62 1689379-8 1990 When cells were permeabilized by treatment with digitonin, Ca2(+)-dependent catecholamine secretion was slightly, but consistently, greater from IGF-I-treated cells than from untreated cells. Catecholamines 76-89 insulin like growth factor 1 Homo sapiens 145-150 1689379-9 1990 Our results suggest that IGF-I may enhance catecholamine secretion partly by increasing Ca2+ entry into the cells and partly by affecting a step distal to Ca2+ entry. Catecholamines 43-56 insulin like growth factor 1 Homo sapiens 25-30 1689379-9 1990 Our results suggest that IGF-I may enhance catecholamine secretion partly by increasing Ca2+ entry into the cells and partly by affecting a step distal to Ca2+ entry. Catecholamines 43-56 carbonic anhydrase 2 Homo sapiens 88-91 2313983-1 1990 Chromogranin A is a soluble protein that is stored and released with catecholamines from their secretory vesicles. Catecholamines 69-83 chromogranin A Homo sapiens 0-14 1970632-1 1990 The aim of the study was to analyse the beta 2-adrenoceptor selectivity earlier found in two series of catecholamines and one series of resorcinolamines (Johansson et al. Catecholamines 103-117 beta-2 adrenergic receptor Cavia porcellus 40-59 2299343-0 1990 Monoamine oxidase (MAO)-A but not MAO-B inhibitors potentiate tyramine-induced catecholamine release from PC12 cells. Catecholamines 79-92 monoamine oxidase A Rattus norvegicus 0-25 2362932-1 1990 The authors described a cooperative effect of glucocorticoids, catecholamines and high density lipoproteins (HDLP), based on increased hexokinase and glucokinase biosynthesis in the liver, resulting in elevated activity of the respective enzymes. Catecholamines 63-77 hexokinase 1 Homo sapiens 135-145 2362932-1 1990 The authors described a cooperative effect of glucocorticoids, catecholamines and high density lipoproteins (HDLP), based on increased hexokinase and glucokinase biosynthesis in the liver, resulting in elevated activity of the respective enzymes. Catecholamines 63-77 glucokinase Homo sapiens 150-161 2307236-1 1990 Previously we reported that astroglial cells cultured from mouse brain synthesize and secrete nerve growth factor (NGF) and that, in quiescent cells, catecholamines markedly increase the NGF content in the conditioned medium (CM). Catecholamines 150-164 nerve growth factor Mus musculus 187-190 2406199-4 1990 Chromogranin A is coreleased with catecholamines by exocytosis from vesicles in the adrenal medulla and sympathetic nerve endings. Catecholamines 34-48 chromogranin A Homo sapiens 0-14 2227123-6 1990 Moreover, although intravenous injection of CGRP (5.67 nmol/kg) elicited a significant increase in plasma epinephrine and norepinephrine concentrations, concomitant administration of epinephrine and norepinephrine, inducing a more prominent rise in plasma catecholamines than those induced by CGRP, affected neither plasma glucose nor insulin levels. Catecholamines 256-270 calcitonin-related polypeptide alpha Rattus norvegicus 44-48 2227123-7 1990 Finally, plasma insulin levels obtained by simulating CGRP-induced changes in plasma glucose or glucose plus catecholamine levels by infusion of glucose or glucose plus catecholamines were not different from those induced by CGRP injection. Catecholamines 109-122 calcitonin-related polypeptide alpha Rattus norvegicus 54-58 2227123-7 1990 Finally, plasma insulin levels obtained by simulating CGRP-induced changes in plasma glucose or glucose plus catecholamine levels by infusion of glucose or glucose plus catecholamines were not different from those induced by CGRP injection. Catecholamines 169-183 calcitonin-related polypeptide alpha Rattus norvegicus 54-58 1690819-1 1990 Previous work (Maxwell and Forbes: Development 101:767-776, 1987) has shown that an overlay of reconstituted basement membrane-like (RBM) gel dramatically increased the number of catecholamine-positive (CA+) cells which differentiated in neural crest cultures. Catecholamines 179-192 RNA binding motif protein Y-linked family 1 member A1 Homo sapiens 133-136 2299343-2 1990 Selective monoamine oxidase (MAO)-A (clorgyline and moclobemide) and not MAO-B inhibitors (l-deprenyl, AGN 1135, and Ro 16-6491) potentiate the catecholamine-releasing action of tyramine significantly more than that of K+. Catecholamines 144-157 monoamine oxidase A Rattus norvegicus 10-35 2147376-3 1990 Autoradiographic studies have shown that some V1 receptors are localized presynaptically on catecholaminergic neuronal terminals in the mouse lateral septum, suggesting that vasopressin may act via modulation of catecholamine release. Catecholamines 92-105 arginine vasopressin Rattus norvegicus 174-185 2239489-0 1990 Catechol-O-methyltransferase and its role in catecholamine metabolism. Catecholamines 45-58 catechol-O-methyltransferase Homo sapiens 0-28 2173366-4 1990 Reports differ as to whether circulating catecholamines can release ACTH in vivo by direct action on the pituitary. Catecholamines 41-55 proopiomelanocortin Homo sapiens 68-72 2375503-8 1990 The augmentation of blood glucose was discussed in connection with influences of the likewise increased thyrotropin-releasing hormone and thyrotropin on the increased plasma levels of catecholamines, with secondary increased plasma levels of glucagon as well as decreased insulin levels after SCGx and exposure to cold. Catecholamines 184-198 thyrotropin releasing hormone Rattus norvegicus 104-133 2350237-5 1990 Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism. Catecholamines 209-222 calmodulin 2 Mus musculus 278-288 1978998-15 1990 Since it has been demonstrated that arcuate NPY neurons are projected to other hypothalamic areas, such as the paraventricular and dorsomedial nuclei, it might be speculated that arcuate 5-HT/NPY and catecholamines/NPY interactions might be involved in regulation of behavior and neuroendocrine functions. Catecholamines 200-214 neuropeptide Y Homo sapiens 44-47 1979934-10 1990 Enoximone thus causes positive inotropic effects and potentiates the effects of catecholamines acting through both beta 1- and beta 2-AR. Catecholamines 80-94 adrenoceptor beta 1 Homo sapiens 115-136 2196058-1 1990 Insulin receptor activity and its relationship with catecholamines and serotonin were investigated in rat brain using Triton X-100 extracts from total membranes, synaptosomes and choroid plexus in experimental hypothyroidism and hyperthyroidism. Catecholamines 52-66 insulin receptor Rattus norvegicus 0-16 2196058-2 1990 Insulin receptor activity was assessed by binding to [125I]insulin and catecholamines by high performance liquid chromatography. Catecholamines 71-85 insulin receptor Rattus norvegicus 0-16 2201297-1 1990 Insulin receptor activity and its relationship with catecholamines in rat young, middle aged and old red blood cells were investigated in experimental hypothyroidism and hyperthyroidism. Catecholamines 52-66 insulin receptor Rattus norvegicus 0-16 1976425-1 1990 We have recently assigned a major stimulatory role to the brain catecholamines (CA) via alpha 1 and beta receptors on CRH-ACTH secretion, e.g. in the physiological response to stress. Catecholamines 64-78 corticotropin releasing hormone Rattus norvegicus 118-121 2153488-6 1990 An arginine vasopressin level of 18 X 10(12) mol/l, which can be achieved physiologically, increased the sensitivity of platelets to adenosine 5"-pyrophosphate and collagen in vitro; the same concentration of arginine vasopressin caused a potentiation of the effect of catecholamines on the response of platelets to sodium arachidonate. Catecholamines 269-283 arginine vasopressin Homo sapiens 12-23 2404624-1 1990 In cultured cells and isolated perfused organs, catecholamines are coreleased with chromogranin A (CgA) from adrenal chromaffin cells and sympathetic neurons. Catecholamines 48-62 chromogranin A Homo sapiens 83-97 2404624-1 1990 In cultured cells and isolated perfused organs, catecholamines are coreleased with chromogranin A (CgA) from adrenal chromaffin cells and sympathetic neurons. Catecholamines 48-62 chromogranin A Homo sapiens 99-102 1980419-8 1990 To elucidate neuronal influences, we tested various neurotransmitters and found that catecholamines and their analogues have stimulatory effects on NGF synthesis of nonneuronal cells. Catecholamines 85-99 nerve growth factor Rattus norvegicus 148-151 2192824-0 1990 Relationship between plasma catecholamines and the renin-aldosterone system during exercise in normal and essential hypertensive subjects. Catecholamines 28-42 renin Homo sapiens 51-56 2403522-9 1990 Catecholamine content in microdissected nuclei of the LHRH neuronal system [medial preoptic nucleus, suprachiasmatic nucleus, retrochiasmatic area, arcuate nucleus (ARC), and median eminence (ME)] was measured by HPLC with electrochemical detection. Catecholamines 0-13 gonadotropin releasing hormone 1 Rattus norvegicus 54-58 12106021-2 1990 The alkaline phosphatase labelled probe revealed the presence of tyrosine hydroxylase mRNA in all the major cell groups and cell bodies previously described as containing catecholamine fluorescence or known to contain tyrosine hydroxylase immunoreactivity. Catecholamines 171-184 tyrosine hydroxylase Rattus norvegicus 65-85 2282903-0 1990 The effects of graded exercise on plasma proenkephalin peptide F and catecholamine responses at sea level. Catecholamines 69-82 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 96-99 2176172-7 1990 A plausible explanation for this finding might be downregulation of beta 2-adrenoceptors because of elevated plasma catecholamine level. Catecholamines 116-129 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 68-74 2269460-0 1990 Catecholamines and indolalkylamines of the pia mater and spinal cord in vertebrates. Catecholamines 0-14 RPTOR independent companion of MTOR complex 2 Homo sapiens 43-46 2089098-1 1990 The life span of extracellular catecholamines is limited by the combination of uptake and subsequent intracellular metabolism by either monoamine oxidase (MAO) and/or catechol-O-methyl transferase (COMT). Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 167-196 1980787-3 1990 The number of catecholamine cells increased dramatically by embryonic day 9.5-10; at gestation days 10.5-11 numerous TH positive cells bearing many neurites were localized in the ventral part of the mesencephalon but they were not yet separated into two different groups (A9 and A10). Catecholamines 14-27 tyrosine hydroxylase Mus musculus 117-119 1969278-7 1990 Perhaps TH-positive, catecholamine-negative neurons are more common than previously held or alternatively, TH expression in non-catecholamine neurons is induced by perturbations such as grafting brain tissue. Catecholamines 128-141 tyrosine hydroxylase Homo sapiens 107-109 2279621-10 1990 Here we report for the first time the complete sequence of a human pseudogene for phenylethanolamine N-methyltransferase and this is the first report of cloning of pseudogene for catecholamine biosynthetic enzymes. Catecholamines 179-192 phenylethanolamine N-methyltransferase Homo sapiens 82-120 2193112-5 1990 With the use of a specific immunoradiometric assay, we have demonstrated that NPY is released into the peripheral circulation during psychological stress together with catecholamines. Catecholamines 168-182 neuropeptide Y Rattus norvegicus 78-81 2089098-1 1990 The life span of extracellular catecholamines is limited by the combination of uptake and subsequent intracellular metabolism by either monoamine oxidase (MAO) and/or catechol-O-methyl transferase (COMT). Catecholamines 31-45 catechol-O-methyltransferase Homo sapiens 198-202 2266781-4 1990 In a following 60-min period, when the hypothalami from the treatment groups were incubated without IL-1 beta, it resulted in sharp declines in the release of NE and DA, confirming that IL-1 beta was the stimulus for the increases in catecholamine release in the previous incubation period. Catecholamines 234-247 interleukin 1 beta Rattus norvegicus 186-195 1967813-5 1990 It is suggested that this lower response to catecholamines at the end of pregnancy could be a cause for the reduced success of beta 2-adrenergic drugs to stop premature labor. Catecholamines 44-58 hemoglobin, beta adult minor chain Mus musculus 127-133 2266781-5 1990 It is concluded that IL-1 beta stimulates the release of catecholamines (and probably other neurotransmitters) in the brain which, in turn, mediate its central and neuroendocrine actions. Catecholamines 57-71 interleukin 1 beta Rattus norvegicus 21-30 1968233-6 1990 This provides an explanation for some of the apparent contradictions in interpreting the data from previous studies on the effects of catecholamines on the secretion of ACTH. Catecholamines 134-148 proopiomelanocortin Homo sapiens 169-173 1968265-0 1990 Tyrosine hydroxylase and enkephalin in nuclei of the solitary tracts: co-existence and convergent synaptic input to catecholamine neurons. Catecholamines 116-129 tyrosine hydroxylase Homo sapiens 0-20 2106713-0 1990 Effect of castration on eicosanoid and catecholamine-induced luteinizing hormone-releasing hormone release in vitro. Catecholamines 39-52 gonadotropin releasing hormone 1 Rattus norvegicus 61-98 2308223-3 1990 The pretreatment of samples such as deproteinization was also important for the accurate results and the analysis of plasma catecholamines and hemoglobin A1c were described as examples with use of column switching technique, step-wise separation, gradient elution method on TSK gels. Catecholamines 124-138 tsukushi, small leucine rich proteoglycan Homo sapiens 274-277 20504631-1 1990 Phosphorylation of tyrosine hydroxylase, the rate-limiting enzyme, by a variety of protein kinases provides multiple mechanisms for the regulation of catecholamine synthesis. Catecholamines 150-163 tyrosine hydroxylase Homo sapiens 19-39 2260105-1 1990 Tetanus toxin blocks Ca2(+)-evoked catecholamine release from permeabilized bovine adrenal chromaffin cells preloaded with gangliosides. Catecholamines 35-48 carbonic anhydrase 2 Bos taurus 21-24 2404349-0 1990 Inverse correlation between N-myc amplification and catecholamine metabolism in children with advanced neuroblastoma. Catecholamines 52-65 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 28-33 2404349-1 1990 The relationship between urinary excretion of catecholamine and/or its metabolites before the initiation of therapy and the genomic amplification of N-myc of the extirpated primary tumors was studied in 32 patients who had advanced neuroblastoma (stages III and IV). Catecholamines 46-59 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 149-154 2304627-1 1990 Catecholamine secretion evoked by caffeine (40 mM) was markedly enhanced by replacing NaCl in the medium with sucrose or KCl in the absence, but not in the presence, of extracellular Ca2+ and Mg2+ in both perfused adrenal glands and isolated chromaffin cells of the guinea pig. Catecholamines 0-13 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 183-186 2281657-0 1990 [Catecholamine excretion in diabetics on insulin treatment]. Catecholamines 1-14 insulin Homo sapiens 41-48 2304627-3 1990 These results indicate that extracellular Na+ inhibits caffeine from stimulating catecholamine secretion, which may be mediated by a release of Ca2+ from intracellular storage sites in the adrenal chromaffin cells in the presence of extracellular Ca2+ and/or Mg2+. Catecholamines 81-94 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 247-250 2404349-5 1990 These data suggest that an inverse regulatory mechanism might be present between the N-myc amplification and catecholamine metabolism in patients who have advanced neuroblastoma, possibly at the level of gene and/or enzyme. Catecholamines 109-122 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 85-90 33775645-0 2021 Inhibition of the norepinephrine transporter rescues vascular hyporeactivity to catecholamine in obstructive jaundice. Catecholamines 80-93 solute carrier family 6 member 2 Rattus norvegicus 18-44 6170913-0 1981 Somatostatin and substance P inhibit catecholamine secretion from isolated cells of guinea-pig adrenal medulla. Catecholamines 37-50 somatostatin Cavia porcellus 0-12 2837475-3 1988 Glucocorticoid treatment (1 X 10(-7) M) produced a 2.2 +/- 0.4-fold (n = 8) increase in beta 2-adrenergic receptor number (maximum) between 6 and 12 h) as determined by radioligand binding and a similar increase in catecholamine-stimulated adenylate cyclase activity. Catecholamines 215-228 beta-2 adrenergic receptor Mesocricetus auratus 88-114 2837475-7 1988 These studies indicate that glucocorticoids regulate the beta 2-adrenergic receptor-adenylate cyclase system by controlling the rate of transcription of the beta 2-adrenergic receptor gene and hence the responsiveness of the enzyme to catecholamine stimulation. Catecholamines 235-248 beta-2 adrenergic receptor Mesocricetus auratus 57-83 2837475-7 1988 These studies indicate that glucocorticoids regulate the beta 2-adrenergic receptor-adenylate cyclase system by controlling the rate of transcription of the beta 2-adrenergic receptor gene and hence the responsiveness of the enzyme to catecholamine stimulation. Catecholamines 235-248 beta-2 adrenergic receptor Mesocricetus auratus 157-183 33972609-7 2021 Nevertheless, four patients were heterozygous carriers of rare variants of ATP7B gene, which is related to catecholamines. Catecholamines 107-121 ATPase copper transporting beta Homo sapiens 75-80 33764618-3 2021 Here we demonstrate that PTP-MEG2 controls multiple steps of catecholamine secretion. Catecholamines 61-74 protein tyrosine phosphatase non-receptor type 9 Homo sapiens 29-33 33764618-4 2021 Biochemical and crystallographic analyses reveal key residues that govern the interaction between PTP-MEG2 and its substrate, a peptide containing the phosphorylated NSF-pY83 site, specify PTP-MEG2 substrate selectivity, and modulate the fusion of catecholamine-containing vesicles. Catecholamines 248-261 protein tyrosine phosphatase non-receptor type 9 Homo sapiens 102-106 33764618-4 2021 Biochemical and crystallographic analyses reveal key residues that govern the interaction between PTP-MEG2 and its substrate, a peptide containing the phosphorylated NSF-pY83 site, specify PTP-MEG2 substrate selectivity, and modulate the fusion of catecholamine-containing vesicles. Catecholamines 248-261 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 166-169 33764618-4 2021 Biochemical and crystallographic analyses reveal key residues that govern the interaction between PTP-MEG2 and its substrate, a peptide containing the phosphorylated NSF-pY83 site, specify PTP-MEG2 substrate selectivity, and modulate the fusion of catecholamine-containing vesicles. Catecholamines 248-261 protein tyrosine phosphatase non-receptor type 9 Homo sapiens 193-197 33034000-0 2021 Utility of Low Dose Vasopressin for Persistent Pulmonary Hypertension of Newborn with Catecholamine Refractory Shock. Catecholamines 86-99 arginine vasopressin Homo sapiens 20-31 33034000-1 2021 OBJECTIVE: To evaluate the effect of low dose vasopressin on the hemodynamics of neonates with persistent pulmonary hypertension and catecholamine refractory shock. Catecholamines 133-146 arginine vasopressin Homo sapiens 46-57 22237745-1 2012 INTRODUCTION: Renalase is an enzyme released by the kidneys, which breaks down catecholamines in the blood and thus may regulate blood pressure. Catecholamines 79-93 renalase, FAD dependent amine oxidase Homo sapiens 14-22 33814251-9 2021 Furthermore, patients in the high IL-6 group significantly more frequently received catecholamine therapy (P = 0.005), venoarterial extracorporeal membrane oxygenation (P = 0.029), and artificial respirator support (P = 0.021) in the acute phase of myocarditis. Catecholamines 84-97 interleukin 6 Homo sapiens 34-38 33800219-3 2021 Acknowledging that CKD and CKD progression are associated with increased sympathetic tone, which is implicated in CVR, and that renalase metabolizes catecholamines, we aimed to evaluate the relationship between renalase serum levels (RNLS) and cardiovascular and renal outcomes. Catecholamines 149-163 renalase, FAD dependent amine oxidase Homo sapiens 128-136 22626958-2 2012 It has been recently postulated that the loss or reduced levels of renalase in patients with chronic renal disease are, at least in part, responsible for elevated plasma catecholamine levels, which leads to increased CVD. Catecholamines 170-183 renalase, FAD dependent amine oxidase Homo sapiens 67-75 12097482-2 2002 Calcium influx is required for PACAP-stimulated secretion of catecholamines and neuropeptides. Catecholamines 61-75 adenylate cyclase activating polypeptide 1 Homo sapiens 31-36 22415317-6 2012 Experimental in vitro studies showed that renalase degrades catecholamines and thus may have a significant hemodynamic effect in vivo, for example may decrease cardiac contractility, heart rate, and blood pressure. Catecholamines 60-74 renalase, FAD dependent amine oxidase Homo sapiens 42-50 17520784-10 2007 Sleep, however, substantially decreased numbers of CD14(dim)CD16+ monocytes, probably reflecting increased margination of the cells upon a sleep-related drop in catecholamine release. Catecholamines 161-174 CD14 molecule Homo sapiens 51-55 34953210-2 2022 Signaling pathways mediated by catecholamine receptors, such as beta3-adrenergic receptor pathway, can induce body energy expenditure via activating thermogenesis of adipose tissue. Catecholamines 31-44 adrenergic receptor, beta 3 Mus musculus 64-89 8082488-5 1994 COMT inhibitors decrease tissue degradation of catecholamines, including dopamine. Catecholamines 47-61 catechol-O-methyltransferase Homo sapiens 0-4 34343670-6 2022 The expression of leptin and its receptor is influenced by numerous factors including sex steroids, stress and stress-induced catecholamines and glucocorticoids though their effect in non-mammalian vertebrates is hard to be generalized due to limited studies. Catecholamines 126-140 leptin Homo sapiens 18-24 34545616-5 2022 It was also put into question whether many physiological discoveries published based on the notion that renalase is secreted into the blood and acts by oxidation of catecholamines can still be considered valid. Catecholamines 165-179 renalase, FAD dependent amine oxidase Homo sapiens 104-112 34952194-1 2022 Phenylalanine hydroxylase (PAH) is involved in immune defence reactions by providing the starting material, tyrosine, to synthesise catecholamines and melanin. Catecholamines 132-146 phenylalanine hydroxylase Homo sapiens 0-25 34952194-1 2022 Phenylalanine hydroxylase (PAH) is involved in immune defence reactions by providing the starting material, tyrosine, to synthesise catecholamines and melanin. Catecholamines 132-146 phenylalanine hydroxylase Homo sapiens 27-30 34967939-9 2021 CONCLUSIONS: Increasing the dose of catecholamines is associated with higher lactate and NSE concentration, which may suggest their importance for tissue oxygen delivery, anaerobic metabolism, and organ function early after OHCA. Catecholamines 36-50 enolase 2 Homo sapiens 89-92 34767786-8 2021 SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline). Catecholamines 205-219 adenosine A2a receptor Homo sapiens 44-52 34767786-2 2021 The 3.2 A X-ray crystal structure of human beta2 AR active-state in combination with the endogenous low affinity agonist adrenaline offers an ideal starting structure for studying the binding of various catecholamines to adrenergic receptors. Catecholamines 203-217 adenosine A2a receptor Homo sapiens 43-51 34767786-8 2021 SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline). Catecholamines 205-219 adrenoceptor beta 2 Homo sapiens 17-42 34756930-3 2021 All these cerebrovascular diseases may trigger pronounced catecholamine surges through diverse ways, including stimulation of hypothalamic-pituitary adrenal axis, dysregulation of autonomic system, and secretion of adrenocorticotropic hormone. Catecholamines 58-71 proopiomelanocortin Homo sapiens 215-242 34919642-5 2021 All 3 also had microscopic findings of myocardial necrosis associated with supraphysiologic levels of catecholamine, a well-documented finding associated with stress but rarely reported in fatalities associated with child abuse. Catecholamines 102-115 paired box 5 Homo sapiens 0-5 34766253-4 2021 Further, catecholamine metabolites and amphetamine analogs are also potent agonists of TAAR1, implicating the receptor in mediating the monoaminergic system and in substance use disorders. Catecholamines 9-22 trace amine associated receptor 1 Homo sapiens 87-92 34966735-0 2021 ADAM17, A Key Player of Cardiac Inflammation and Fibrosis in Heart Failure Development During Chronic Catecholamine Stress. Catecholamines 102-115 ADAM metallopeptidase domain 17 Homo sapiens 0-6 34966735-7 2021 Hence, this concise review provides a comprehensive insight into the structure of ADAM17, how it is activated and regulated during chronic catecholamine stress in heart failure development. Catecholamines 139-152 ADAM metallopeptidase domain 17 Homo sapiens 82-88 34156537-1 2021 AIMS: Renalase (RNLS) is an enzyme with monoamine oxidase activity that metabolizes circulating catecholamines. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 6-14 34156537-1 2021 AIMS: Renalase (RNLS) is an enzyme with monoamine oxidase activity that metabolizes circulating catecholamines. Catecholamines 96-110 renalase, FAD dependent amine oxidase Homo sapiens 16-20 34884863-1 2021 The ability of NQO2 to increase the production of free radicals under enhanced generation of quinone derivatives of catecholamines is considered to be a component of neurodegenerative disease pathogenesis. Catecholamines 116-130 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 15-19 34597810-7 2021 However, intravenous angiotensin II in catecholamine-resistant septic shock patients showed substantial evidence of raising the MAP to target hemodynamic levels, thus allowing time to treat underlying conditions. Catecholamines 39-52 angiotensinogen Homo sapiens 21-35 34854055-8 2021 Our data show that CCN5 gene transcription and protein levels are induced by catecholamines via beta2-adrenergic receptors. Catecholamines 77-91 cellular communication network factor 5 Mus musculus 19-23 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 261-275 monoamine oxidase A Homo sapiens 302-307 34944578-7 2021 Specifically, in this review, we aimed to discuss the role of catestatin, a potent physiological inhibitor of catecholamine spillover that offers cardioprotective effects. Catecholamines 110-123 chromogranin A Homo sapiens 62-72 34858321-7 2021 Intracranial vascular stenosis may have been caused by a genetic mutation of RNF213 and hypersecretion of catecholamines by MEN2A. Catecholamines 106-120 ret proto-oncogene Homo sapiens 124-129 34614428-2 2021 Angiotensin II causes constriction of arterioles and venules, inhibits the reuptake of norepinephrine, stimulates the release of catecholamines, and hypertrophy of vascular smooth muscle cells. Catecholamines 129-143 angiotensinogen Homo sapiens 0-14 34884498-0 2021 Cardioprotective Effects of Palmitoleic Acid (C16:1n7) in a Mouse Model of Catecholamine-Induced Cardiac Damage Are Mediated by PPAR Activation. Catecholamines 75-88 peroxisome proliferator activated receptor alpha Mus musculus 128-132 34481663-1 2021 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency, caused by a pathogenic variant in the dopa decarboxylase (DDC) gene, is a rare neurometabolic disorder in which catecholamine and serotonin are not synthesized. Catecholamines 179-192 dopa decarboxylase Homo sapiens 12-47 34481663-1 2021 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency, caused by a pathogenic variant in the dopa decarboxylase (DDC) gene, is a rare neurometabolic disorder in which catecholamine and serotonin are not synthesized. Catecholamines 179-192 dopa decarboxylase Homo sapiens 49-53 34481663-1 2021 BACKGROUND: Aromatic L-amino acid decarboxylase (AADC) deficiency, caused by a pathogenic variant in the dopa decarboxylase (DDC) gene, is a rare neurometabolic disorder in which catecholamine and serotonin are not synthesized. Catecholamines 179-192 dopa decarboxylase Homo sapiens 105-123 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 0-14 monoamine oxidase A Homo sapiens 69-74 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 0-14 monoamine oxidase B Homo sapiens 79-84 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 0-14 monoamine oxidase A Homo sapiens 128-133 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 0-14 monoamine oxidase B Homo sapiens 138-143 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 261-275 monoamine oxidase B Homo sapiens 312-317 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 0-14 monoamine oxidase A Homo sapiens 302-307 34503991-3 2021 Catecholamines are metabolized by two isoforms of monoamine oxidase, MAO-A and MAO-B; and although the anatomic localization of MAO-A and MAO-B and substrate specificities of enzyme inhibitors are well characterized, relative susceptibilities of the endogenous catecholamines to enzymatic oxidation by MAO-A and MAO-B have not been studied systematically. Catecholamines 0-14 monoamine oxidase B Homo sapiens 312-317 34503991-7 2021 Since catecholaminergic neurons express mainly MAO-A, the finding that MAO-A is more efficient than MAO-B in metabolizing endogenous catecholamines reinforces the view that the predominant route of intra-neuronal enzymatic oxidation of catecholamines is via MAO-A. Catecholamines 133-147 monoamine oxidase A Homo sapiens 71-76 34503991-7 2021 Since catecholaminergic neurons express mainly MAO-A, the finding that MAO-A is more efficient than MAO-B in metabolizing endogenous catecholamines reinforces the view that the predominant route of intra-neuronal enzymatic oxidation of catecholamines is via MAO-A. Catecholamines 133-147 monoamine oxidase B Homo sapiens 100-105 34503991-7 2021 Since catecholaminergic neurons express mainly MAO-A, the finding that MAO-A is more efficient than MAO-B in metabolizing endogenous catecholamines reinforces the view that the predominant route of intra-neuronal enzymatic oxidation of catecholamines is via MAO-A. Catecholamines 133-147 monoamine oxidase A Homo sapiens 258-263 34503991-7 2021 Since catecholaminergic neurons express mainly MAO-A, the finding that MAO-A is more efficient than MAO-B in metabolizing endogenous catecholamines reinforces the view that the predominant route of intra-neuronal enzymatic oxidation of catecholamines is via MAO-A. Catecholamines 236-250 monoamine oxidase A Homo sapiens 47-52 34503991-7 2021 Since catecholaminergic neurons express mainly MAO-A, the finding that MAO-A is more efficient than MAO-B in metabolizing endogenous catecholamines reinforces the view that the predominant route of intra-neuronal enzymatic oxidation of catecholamines is via MAO-A. Catecholamines 236-250 monoamine oxidase A Homo sapiens 71-76 34503991-7 2021 Since catecholaminergic neurons express mainly MAO-A, the finding that MAO-A is more efficient than MAO-B in metabolizing endogenous catecholamines reinforces the view that the predominant route of intra-neuronal enzymatic oxidation of catecholamines is via MAO-A. Catecholamines 236-250 monoamine oxidase B Homo sapiens 100-105 34503991-7 2021 Since catecholaminergic neurons express mainly MAO-A, the finding that MAO-A is more efficient than MAO-B in metabolizing endogenous catecholamines reinforces the view that the predominant route of intra-neuronal enzymatic oxidation of catecholamines is via MAO-A. Catecholamines 236-250 monoamine oxidase A Homo sapiens 258-263 34503991-10 2021 Significance Statement Endogenous catecholamines are metabolized by monoamine oxidase (MAO)-A and -B, yielding the catecholaldehydes 3,4-dihydroxyphenylacetaldehyde (DOPAL) from dopamine (DA) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) from norepinephrine (NE) and epinephrine (EPI). Catecholamines 34-48 monoamine oxidase A Homo sapiens 68-100 34503991-12 2021 MAO-A is the main route of intra-neuronal metabolism of endogenous catecholamines. Catecholamines 67-81 monoamine oxidase A Homo sapiens 0-5 34834946-1 2021 A bidirectional negative relationship between Hepatitis C virus (HCV) replication and gene expression of the catecholamine biosynthetic enzyme L-Dopa decarboxylase (DDC) was previously shown in the liver and attributed at least to an association of DDC with phosphatidylinositol 3-kinase (PI3K). Catecholamines 109-122 dopa decarboxylase Homo sapiens 165-168 34768597-8 2021 The 4V OT also induced Fos in tyrosine hydroxylase (TH; marker of catecholamine neurons) (+) neurons (25 +- 7%) relative to vehicle (0.8 +- 0.3%). Catecholamines 66-79 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-26 34707293-2 2021 Here we report that the regulation of glycogen metabolism by catecholamines is critical for UCP1 expression. Catecholamines 61-75 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 92-96 34707293-5 2021 Unexpectedly, we observed that glycogen synthesis and degradation are increased in response to catecholamines, and that glycogen turnover is required to produce reactive oxygen species leading to the activation of p38 MAPK, which drives UCP1 expression. Catecholamines 95-109 mitogen-activated protein kinase 14 Mus musculus 214-222 34707293-5 2021 Unexpectedly, we observed that glycogen synthesis and degradation are increased in response to catecholamines, and that glycogen turnover is required to produce reactive oxygen species leading to the activation of p38 MAPK, which drives UCP1 expression. Catecholamines 95-109 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 237-241 34510286-3 2021 As both acute hypoxia and high plasma catecholamine levels may elicit PE, we had originally expected that adrenergic blockade may attenuate the severity of hypoxic pulmonary injury. Catecholamines 38-51 prolyl endopeptidase Rattus norvegicus 70-72 34870059-7 2021 The tumor was histologically comprised of small polygonal cells with high cellularity and was immunohistochemically positive for all 3 catecholamine-synthesizing enzymes: tyrosine hydroxylase (very weak), dopamine beta-hydroxylase (heterogeneous), and phenylethanolamine N-methyltransferase (very weak). Catecholamines 135-148 paired box 5 Homo sapiens 129-134 34870059-13 2021 Histological findings in our case give a possible hypothesis that the mechanism underlying a dopamine-secreting pheochromocytoma is associated with immature catecholamine vesicles in which dopamine beta-hydroxylase is localized, thus resulting in inhibited conversion from dopamine to norepinephrine. Catecholamines 157-170 dopamine beta-hydroxylase Homo sapiens 189-214 34834946-1 2021 A bidirectional negative relationship between Hepatitis C virus (HCV) replication and gene expression of the catecholamine biosynthetic enzyme L-Dopa decarboxylase (DDC) was previously shown in the liver and attributed at least to an association of DDC with phosphatidylinositol 3-kinase (PI3K). Catecholamines 109-122 dopa decarboxylase Homo sapiens 249-252 34834946-5 2021 To counteract the effect of catecholamines, HCV, apart from the already reported effects on DDC, causes the down-regulation of tyrosine hydroxylase that encodes the rate-limiting enzyme of catecholamine biosynthesis and suppresses dopamine beta-hydroxylase mRNA and protein amounts, while increasing the catecholamine degradation enzyme monoamine oxidase. Catecholamines 28-42 dopamine beta-hydroxylase Homo sapiens 231-256 34288568-0 2021 Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/beta2 -AR/MACC1 axis. Catecholamines 109-122 G protein-coupled receptor 162 Homo sapiens 123-128 34415184-4 2021 In heart failure, catecholamines are elevated, leading to chronic betaAR activation and contributing to the detrimental effects in the heart. Catecholamines 18-32 adrenergic receptor, beta 1 Mus musculus 66-72 34415184-5 2021 We hypothesized that immune cell beta2AR plays a critical role in the development of heart failure in response to chronic catecholamine elevations through their regulation of immune cell recruitment. Catecholamines 122-135 adenosine A2a receptor Mus musculus 33-40 34415184-11 2021 These findings demonstrate an important role for immune cell beta2AR expression in the heart"s response to chronically elevated catecholamines. Catecholamines 128-142 adenosine A2a receptor Mus musculus 61-68 34455221-3 2021 The beta2 adrenergic receptor (beta2AR) is a catecholamine-liganded GPCR that is involved in cancer progression and wound healing. Catecholamines 45-58 adrenoceptor beta 2 Homo sapiens 4-29 34455221-3 2021 The beta2 adrenergic receptor (beta2AR) is a catecholamine-liganded GPCR that is involved in cancer progression and wound healing. Catecholamines 45-58 adenosine A2a receptor Homo sapiens 31-38 34455221-3 2021 The beta2 adrenergic receptor (beta2AR) is a catecholamine-liganded GPCR that is involved in cancer progression and wound healing. Catecholamines 45-58 adrenoceptor alpha 2B Homo sapiens 68-72 34455221-10 2021 This study suggests that beta2AR is a GPCR that regulates HA production, and that stimulation with a catecholamine (beta2 agonist) can regulate HA production. Catecholamines 101-114 adenosine A2a receptor Homo sapiens 25-32 34455221-10 2021 This study suggests that beta2AR is a GPCR that regulates HA production, and that stimulation with a catecholamine (beta2 agonist) can regulate HA production. Catecholamines 101-114 G protein-coupled receptor 162 Homo sapiens 116-121 34805785-4 2021 CLS and cardiac CL species were significantly downregulated in cardiomyocytes following catecholamine-induced cardiac damage in mice, accompanied by increased oxygen consumption rates, signs of oxidative stress, and mitochondrial uncoupling. Catecholamines 88-101 cardiolipin synthase 1 Mus musculus 0-3 34288568-12 2021 However, beta2 -AR antagonist ICI-118,551 or MACC1 silencing effectively blocked the catecholamine-induced neuroendocrine phenotypic transformation and eliminated depression-enhanced GC migration and invasion. Catecholamines 85-98 MET transcriptional regulator MACC1 Homo sapiens 45-50 34288568-14 2021 CONCLUSIONS: Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the beta2 -AR/MACC1 axis, while beta2 -AR antagonist or MACC1 silencing could reverse it, showing promising potential therapeutic strategies for improving the outcome of GC patients with comorbid depression. Catecholamines 13-26 G protein-coupled receptor 162 Homo sapiens 138-143 34288568-14 2021 CONCLUSIONS: Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the beta2 -AR/MACC1 axis, while beta2 -AR antagonist or MACC1 silencing could reverse it, showing promising potential therapeutic strategies for improving the outcome of GC patients with comorbid depression. Catecholamines 13-26 MET transcriptional regulator MACC1 Homo sapiens 148-153 34288568-0 2021 Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/beta2 -AR/MACC1 axis. Catecholamines 109-122 MET transcriptional regulator MACC1 Homo sapiens 133-138 34288568-10 2021 Further, depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor (beta2 -AR) and upregulated MACC1 expression, and thus promoting neuroendocrine phenotypic transformation through direct binding between MACC1 and synaptophysin. Catecholamines 31-44 adrenoceptor beta 2 Homo sapiens 71-97 34288568-14 2021 CONCLUSIONS: Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the beta2 -AR/MACC1 axis, while beta2 -AR antagonist or MACC1 silencing could reverse it, showing promising potential therapeutic strategies for improving the outcome of GC patients with comorbid depression. Catecholamines 13-26 G protein-coupled receptor 162 Homo sapiens 166-171 34288568-10 2021 Further, depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor (beta2 -AR) and upregulated MACC1 expression, and thus promoting neuroendocrine phenotypic transformation through direct binding between MACC1 and synaptophysin. Catecholamines 31-44 G protein-coupled receptor 162 Homo sapiens 99-104 34288568-14 2021 CONCLUSIONS: Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the beta2 -AR/MACC1 axis, while beta2 -AR antagonist or MACC1 silencing could reverse it, showing promising potential therapeutic strategies for improving the outcome of GC patients with comorbid depression. Catecholamines 13-26 MET transcriptional regulator MACC1 Homo sapiens 190-195 34288568-10 2021 Further, depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor (beta2 -AR) and upregulated MACC1 expression, and thus promoting neuroendocrine phenotypic transformation through direct binding between MACC1 and synaptophysin. Catecholamines 31-44 MET transcriptional regulator MACC1 Homo sapiens 126-131 34288568-10 2021 Further, depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor (beta2 -AR) and upregulated MACC1 expression, and thus promoting neuroendocrine phenotypic transformation through direct binding between MACC1 and synaptophysin. Catecholamines 31-44 MET transcriptional regulator MACC1 Homo sapiens 235-240 34288568-10 2021 Further, depression-associated catecholamine specifically bound to the beta-2 adrenergic receptor (beta2 -AR) and upregulated MACC1 expression, and thus promoting neuroendocrine phenotypic transformation through direct binding between MACC1 and synaptophysin. Catecholamines 31-44 synaptophysin Homo sapiens 245-258 34288568-12 2021 However, beta2 -AR antagonist ICI-118,551 or MACC1 silencing effectively blocked the catecholamine-induced neuroendocrine phenotypic transformation and eliminated depression-enhanced GC migration and invasion. Catecholamines 85-98 G protein-coupled receptor 162 Homo sapiens 9-14 34417872-1 2021 Argininosuccinate lyase (ASL) is essential for the NO-dependent regulation of tyrosine hydroxylase (TH) and thus for catecholamine production. Catecholamines 117-130 argininosuccinate lyase Mus musculus 0-23 34424614-10 2021 Moreover, in 7 days, the need of catecholamines (calculated as vasoactive-inotropic score) decreased from 32.0 (11.1, 47.0) at baseline to 5.3 (0, 16.1) in the non-ischaemic group (P = 0.001) and from 35.2 (18.11, 67.0) to zero (0, 0) in the AMI-related CS group (P = 0.001). Catecholamines 33-47 citrate synthase Homo sapiens 254-256 34417872-1 2021 Argininosuccinate lyase (ASL) is essential for the NO-dependent regulation of tyrosine hydroxylase (TH) and thus for catecholamine production. Catecholamines 117-130 argininosuccinate lyase Mus musculus 25-28 34417872-2 2021 Using a conditional mouse model with loss of ASL in catecholamine neurons, we demonstrate that ASL is expressed in dopaminergic neurons in the substantia nigra pars compacta, including the ALDH1A1 + subpopulation that is pivotal for the pathogenesis of Parkinson disease (PD). Catecholamines 52-65 argininosuccinate lyase Mus musculus 95-98 34417872-3 2021 Neuronal loss of ASL results in catecholamine deficiency, in accumulation and formation of tyrosine aggregates, in elevation of alpha-synuclein, and phenotypically in motor and cognitive deficits. Catecholamines 32-45 argininosuccinate lyase Mus musculus 17-20 34679699-5 2021 In the present study, we assessed the influences of glutamate on the autoxidation of catecholamines, the copper- and copper-containing ceruloplasmin-mediated oxidation of catecholamines, the catecholamine-induced formation of quinoprotein, catecholamine/copper-induced hydroxyl radicals, and DNA damage in vitro. Catecholamines 171-185 ceruloplasmin Homo sapiens 135-148 34229214-0 2021 Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Catecholamines 47-60 neuropeptide Y Gallus gallus 0-14 34229214-2 2021 This study aimed to investigate the changes in catecholamine and indolamine metabolism in response to the central action of neuropeptide Y (NPY) in different feeding statuses and the underlying mechanisms. Catecholamines 47-60 neuropeptide Y Gallus gallus 124-138 34229214-2 2021 This study aimed to investigate the changes in catecholamine and indolamine metabolism in response to the central action of neuropeptide Y (NPY) in different feeding statuses and the underlying mechanisms. Catecholamines 47-60 neuropeptide Y Gallus gallus 140-143 34229214-4 2021 Central NPY significantly decreased L-tyrosine concentration, the precursor of catecholamines under feeding condition, but not under fasting condition. Catecholamines 79-93 neuropeptide Y Gallus gallus 8-11 34229214-8 2021 Therefore, the mechanism of action of catecholamines with central NPY under feeding condition was elucidated in Experiment 2. Catecholamines 38-52 neuropeptide Y Gallus gallus 66-69 34229214-12 2021 In conclusion, central NPY modifies a part of catecholamine metabolism, which is illustrated by the involvement of dopamine transmission and metabolism under feeding but not fasting conditions. Catecholamines 46-59 neuropeptide Y Gallus gallus 23-26 34575135-5 2021 In addition, ET-1 is involved in the complex regulation of BP through synergistic interactions with angiotensin II, regulates the production of catecholamines and sympathetic activity, affects renal hemodynamics and water-salt balance, and regulates baroreceptor activity and myocardial contractility. Catecholamines 144-158 endothelin 1 Homo sapiens 13-17 34631843-0 2021 Catecholamine-Induced Secondary Takotsubo Syndrome in Children With Severe Enterovirus 71 Infection and Acute Heart Failure: A 20-year Experience of a Single Institute. Catecholamines 0-13 immunoglobulin kappa variable 1-27 Homo sapiens 125-129 34679357-3 2021 The catechol O-methyltransferase (COMT) gene is located within the 22q11.2 region, and its product is an enzyme involved in transferring a methyl group from S-adenosylmethionine to catecholamines, including dopamine. Catecholamines 181-195 catechol-O-methyltransferase Homo sapiens 4-32 34679357-3 2021 The catechol O-methyltransferase (COMT) gene is located within the 22q11.2 region, and its product is an enzyme involved in transferring a methyl group from S-adenosylmethionine to catecholamines, including dopamine. Catecholamines 181-195 catechol-O-methyltransferase Homo sapiens 34-38 34630037-3 2021 Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and consequently, DBH inhibition reduces catecholamines. Catecholamines 127-141 dopamine beta hydroxylase Mus musculus 0-25 34630037-3 2021 Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and consequently, DBH inhibition reduces catecholamines. Catecholamines 127-141 dopamine beta hydroxylase Mus musculus 27-30 34630037-3 2021 Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and consequently, DBH inhibition reduces catecholamines. Catecholamines 127-141 dopamine beta hydroxylase Mus musculus 104-107 34603559-2 2021 Renalase is a catecholamine-degrading enzyme playing a major role in blood pressure control. Catecholamines 14-27 renalase, FAD dependent amine oxidase Homo sapiens 0-8 34604361-0 2021 Catecholamine Surges Cause Cardiomyocyte Necroptosis via a RIPK1-RIPK3-Dependent Pathway in Mice. Catecholamines 0-13 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 59-64 34604361-0 2021 Catecholamine Surges Cause Cardiomyocyte Necroptosis via a RIPK1-RIPK3-Dependent Pathway in Mice. Catecholamines 0-13 receptor-interacting serine-threonine kinase 3 Mus musculus 65-70 34604361-9 2021 Conclusions: A large proportion of cardiomyocyte necrosis induced by excessive beta-adrenergic stimulation belongs to necroptosis and is mediated by a RIPK1-RIPK3-dependent pathway, identifying RIPK1 and RIPK3 as potential therapeutic targets for catecholamine surges. Catecholamines 247-260 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 151-156 34526601-12 2021 The in vitro studies showed that catecholamine-induced endothelial apoptosis was inhibited by NO, arginine, or AKT activator. Catecholamines 33-46 thymoma viral proto-oncogene 1 Mus musculus 111-114 34604361-9 2021 Conclusions: A large proportion of cardiomyocyte necrosis induced by excessive beta-adrenergic stimulation belongs to necroptosis and is mediated by a RIPK1-RIPK3-dependent pathway, identifying RIPK1 and RIPK3 as potential therapeutic targets for catecholamine surges. Catecholamines 247-260 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 194-199 34604361-9 2021 Conclusions: A large proportion of cardiomyocyte necrosis induced by excessive beta-adrenergic stimulation belongs to necroptosis and is mediated by a RIPK1-RIPK3-dependent pathway, identifying RIPK1 and RIPK3 as potential therapeutic targets for catecholamine surges. Catecholamines 247-260 receptor-interacting serine-threonine kinase 3 Mus musculus 204-209 34576151-6 2021 Insulin is known to regulate glucose metabolism, support cognition, enhance the outgrowth of neurons, modulate the release and uptake of catecholamine, and regulate the expression and localization of gamma-aminobutyric acid (GABA). Catecholamines 137-150 insulin Homo sapiens 0-7 34433018-4 2021 Exendin-4, a synthetic analog of GLP-1, increases the synthesis and the release of catecholamines (CAs) by increasing cyclic AMP (cAMP) production, without apparent participation of cAMP-regulated guanine nucleotide exchange factor (Epac). Catecholamines 83-97 glucagon like peptide 1 receptor Homo sapiens 33-38 34466783-5 2021 In addition, in ASCL1-high SCLC, we show ASCL1 complexes with NKX2-1 and PROX1 to co-regulate genes functioning in NOTCH signaling, catecholamine biosynthesis, and cell-cycle processes. Catecholamines 132-145 achaete-scute family bHLH transcription factor 1 Homo sapiens 41-46 34466783-5 2021 In addition, in ASCL1-high SCLC, we show ASCL1 complexes with NKX2-1 and PROX1 to co-regulate genes functioning in NOTCH signaling, catecholamine biosynthesis, and cell-cycle processes. Catecholamines 132-145 NK2 homeobox 1 Homo sapiens 62-68 34351905-3 2021 IL-25 induced beige fat formation in white adipose tissue (WAT) by releasing IL-4 and IL-13 and promoting alternative activation of macrophages that regulate innervation and up-regulate tyrosine hydroxylase (TH) up-regulation to produce more catecholamine including norepinephrine (NE). Catecholamines 242-255 interleukin 25 Mus musculus 0-5 34466783-5 2021 In addition, in ASCL1-high SCLC, we show ASCL1 complexes with NKX2-1 and PROX1 to co-regulate genes functioning in NOTCH signaling, catecholamine biosynthesis, and cell-cycle processes. Catecholamines 132-145 prospero homeobox 1 Homo sapiens 73-78 34245608-3 2021 Constitutive ablation of the activin receptor ALK7 in adipose tissue enhances catecholamine signaling and lipolysis in adipocytes, and protects mice from diet-induced obesity. Catecholamines 78-91 activin A receptor, type IC Mus musculus 46-50 34341386-1 2021 Chromogranin A (CgA) is the precursor of several antimicrobial peptides, such as Catestatin (Cts, bovine CgA344-364), initially described as a potent inhibitor of catecholamines. Catecholamines 163-177 chromogranin A Bos taurus 0-14 34341386-1 2021 Chromogranin A (CgA) is the precursor of several antimicrobial peptides, such as Catestatin (Cts, bovine CgA344-364), initially described as a potent inhibitor of catecholamines. Catecholamines 163-177 chromogranin A Bos taurus 16-19 34245608-7 2021 Mechanistically, combination of ALK7 ablation with either treatment strongly enhanced the levels of beta3-AR, the main adrenergic receptor for catecholamine stimulation of lipolysis, and C/EBPalpha, an upstream regulator of beta3-AR expression. Catecholamines 143-156 activin A receptor, type IC Mus musculus 32-36 34245608-7 2021 Mechanistically, combination of ALK7 ablation with either treatment strongly enhanced the levels of beta3-AR, the main adrenergic receptor for catecholamine stimulation of lipolysis, and C/EBPalpha, an upstream regulator of beta3-AR expression. Catecholamines 143-156 adenosine A3 receptor Mus musculus 100-108 34357092-9 2021 In conclusion, mGluR2 signaling in the dorsal brainstem is crucial for preventing the worsening of hypertension over a relatively long period in SHRs, through a mechanism of catecholamine secretion. Catecholamines 174-187 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 15-21 34367696-2 2021 The purpose of this study was to evaluate the relationship between the plasma levels of catecholamines (such as epinephrine (Ep), norepinephrine (Nep), and dopamine) and vasopressin (antidiuretic hormone (ADH)) and the acquisition of return of spontaneous circulation (ROSC) in OHCA patients. Catecholamines 88-102 epiregulin Homo sapiens 125-127 34367696-2 2021 The purpose of this study was to evaluate the relationship between the plasma levels of catecholamines (such as epinephrine (Ep), norepinephrine (Nep), and dopamine) and vasopressin (antidiuretic hormone (ADH)) and the acquisition of return of spontaneous circulation (ROSC) in OHCA patients. Catecholamines 88-102 arginine vasopressin Homo sapiens 183-203 34320663-6 2022 Generally, mutations that lead to stabilization of HIF2alpha result in distinct catecholamine phenotype through blockade of glucocorticoid-mediated induction of phenylethanolamine N-methyltransferase, leading to the formation of tumors that lack epinephrine. Catecholamines 80-93 endothelial PAS domain protein 1 Homo sapiens 51-60 34320663-6 2022 Generally, mutations that lead to stabilization of HIF2alpha result in distinct catecholamine phenotype through blockade of glucocorticoid-mediated induction of phenylethanolamine N-methyltransferase, leading to the formation of tumors that lack epinephrine. Catecholamines 80-93 phenylethanolamine N-methyltransferase Homo sapiens 161-199 34439627-4 2021 Childhood trauma and functional genetic polymorphisms in catecholamines converting enzymes, such as mono-amino-oxidase A (MAO-A) and catechol-o-methyltransferase (COMT) have been suggested to augment an aggressive behavioral response in adulthood. Catecholamines 57-71 monoamine oxidase A Homo sapiens 100-120 34439627-4 2021 Childhood trauma and functional genetic polymorphisms in catecholamines converting enzymes, such as mono-amino-oxidase A (MAO-A) and catechol-o-methyltransferase (COMT) have been suggested to augment an aggressive behavioral response in adulthood. Catecholamines 57-71 monoamine oxidase A Homo sapiens 122-127 34439627-4 2021 Childhood trauma and functional genetic polymorphisms in catecholamines converting enzymes, such as mono-amino-oxidase A (MAO-A) and catechol-o-methyltransferase (COMT) have been suggested to augment an aggressive behavioral response in adulthood. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 133-161 34439627-4 2021 Childhood trauma and functional genetic polymorphisms in catecholamines converting enzymes, such as mono-amino-oxidase A (MAO-A) and catechol-o-methyltransferase (COMT) have been suggested to augment an aggressive behavioral response in adulthood. Catecholamines 57-71 catechol-O-methyltransferase Homo sapiens 163-167 34381743-2 2021 Arginine vasopressin has gained popularity in recent years as a non-catecholamine vasoactive medication due to its unique properties. Catecholamines 68-81 arginine vasopressin Homo sapiens 9-20 34130840-5 2021 Meanwhile, 15-week of real-ambient PM2.5 exposure decreased the heart rate and amounts of associated catecholamines to induce heart failure in Sirt3 KO mice. Catecholamines 101-115 sirtuin 3 Mus musculus 143-148 34345329-1 2021 Adrenocorticotropic hormone (ACTH)-producing pheochromocytoma can cause a variety of clinical manifestations of excess catecholamine and corticosteroid. Catecholamines 119-132 proopiomelanocortin Homo sapiens 0-27 34345329-1 2021 Adrenocorticotropic hormone (ACTH)-producing pheochromocytoma can cause a variety of clinical manifestations of excess catecholamine and corticosteroid. Catecholamines 119-132 proopiomelanocortin Homo sapiens 29-33 34281748-2 2021 Renalase metabolizes catecholamines and have an important role in blood pressure (BP) regulation. Catecholamines 21-35 renalase, FAD dependent amine oxidase Homo sapiens 0-8 34381974-2 2021 Here, we report that nucleotide-binding oligomerization domain 1 (Nod1) ligand derived from intestinal bacteria modulates catecholamine storage and secretion in mouse adrenal chromaffin cells. Catecholamines 122-135 nucleotide-binding oligomerization domain containing 1 Mus musculus 21-64 34381974-2 2021 Here, we report that nucleotide-binding oligomerization domain 1 (Nod1) ligand derived from intestinal bacteria modulates catecholamine storage and secretion in mouse adrenal chromaffin cells. Catecholamines 122-135 nucleotide-binding oligomerization domain containing 1 Mus musculus 66-70 34200667-1 2021 BACKGROUND/AIMS: Renalase is an enzyme with monoamine oxidase activity that metabolizes catecholamines; therefore, it has a significant influence on arterial blood pressure regulation and the development of cardiovascular diseases. Catecholamines 88-102 renalase, FAD dependent amine oxidase Homo sapiens 17-25 34191746-3 2021 Renalase, whose expression was first confirmed in the kidneys, is a physiologically active substance that decomposes circulating catecholamines; additionally, it has been reported to be present in the skeletal muscles. Catecholamines 129-143 renalase, FAD-dependent amine oxidase Mus musculus 0-8 34191746-10 2021 Conclusion: We demonstrated that exercise training increased the gene expression of renalase in the skeletal muscles and kidneys, thus lowering circulating catecholamine levels. Catecholamines 156-169 renalase, FAD-dependent amine oxidase Mus musculus 84-92 34061169-18 2021 TRANSLATIONAL PERSPECTIVE: The pharmacological inhibition of ATGL activity in adipose tissue improves heart function in a murine model of catecholamine-induced myocardial damage, via significant reduction of cardiac apoptosis and fibrosis. Catecholamines 138-151 patatin-like phospholipase domain containing 2 Mus musculus 61-65 34179127-0 2021 beta1-Blockers Enhance Inotropy of Endogenous Catecholamines in Chronic Heart Failure. Catecholamines 46-60 BCL2 related protein A1 Homo sapiens 0-5 34179127-3 2021 In CHF, concentrations of catecholamines at the beta1-adrenoceptors usually exceed their dissociation constants (K Ds). Catecholamines 26-40 BCL2 related protein A1 Homo sapiens 48-53 34179127-8 2021 This leads to increased positive inotropic effects of endogenous catecholamines due to a beta1-blocker. Catecholamines 65-79 AA1 Homo sapiens 87-94 34150874-5 2021 Under acute stressful conditions, the hyperstimulation of beta-adrenergic receptors (beta-ARs) resulting from excessive release of catecholamines induces intracellular kinases capable of phosphorylating and activating "A Disintegrin and Metalloprotease 17" (ADAM17), a type-I transmembrane protease that plays a central role in acute myocardial inflammation and metabolic lipids dysregulation which are the main hallmarks of TTC. Catecholamines 131-145 ADAM metallopeptidase domain 17 Homo sapiens 218-256 34150874-5 2021 Under acute stressful conditions, the hyperstimulation of beta-adrenergic receptors (beta-ARs) resulting from excessive release of catecholamines induces intracellular kinases capable of phosphorylating and activating "A Disintegrin and Metalloprotease 17" (ADAM17), a type-I transmembrane protease that plays a central role in acute myocardial inflammation and metabolic lipids dysregulation which are the main hallmarks of TTC. Catecholamines 131-145 ADAM metallopeptidase domain 17 Homo sapiens 258-264 34061169-18 2021 TRANSLATIONAL PERSPECTIVE: The pharmacological inhibition of ATGL activity in adipose tissue improves heart function in a murine model of catecholamine-induced myocardial damage, via significant reduction of cardiac apoptosis and fibrosis. Catecholamines 138-151 WD and tetratricopeptide repeats 1 Mus musculus 78-85 35283192-5 2022 Moreover, we show that the acquisition of catechol siderophores and catecholamine stress hormones by S. lugdunensis required the presence of the sst-1 transporter-encoding locus, but not the sst-2 locus. Catecholamines 68-81 susceptibility to tuberculosis 1 Mus musculus 145-150 34063503-12 2021 This study provides novel insight into chronic sympathetic nervous system activation in HF where excessive catecholamines may not only participate in pathological remodeling of the heart but alter other organs due to secretion of EVs with altered miR content. Catecholamines 107-121 microRNA 615 Mus musculus 247-250 34515205-4 2021 OBJECTIVES: Since both NET and DAT are downregulated by AMPH and NK1R activation and share high sequence homology, the objective of the study was to determine the catecholamine transporter specificity in NK1R modulation of AMPH-induced behaviors. Catecholamines 163-176 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus 31-34 34515205-4 2021 OBJECTIVES: Since both NET and DAT are downregulated by AMPH and NK1R activation and share high sequence homology, the objective of the study was to determine the catecholamine transporter specificity in NK1R modulation of AMPH-induced behaviors. Catecholamines 163-176 tachykinin receptor 1 Mus musculus 65-69 34515205-4 2021 OBJECTIVES: Since both NET and DAT are downregulated by AMPH and NK1R activation and share high sequence homology, the objective of the study was to determine the catecholamine transporter specificity in NK1R modulation of AMPH-induced behaviors. Catecholamines 163-176 tachykinin receptor 1 Mus musculus 204-208 35397175-9 2022 A small proportion of ERalpha and GPER1 are localized to catecholaminergic terminals, suggesting that binding at these ERs alters release of catecholamines, including dopamine. Catecholamines 141-155 estrogen receptor 1 Rattus norvegicus 22-29 35397175-9 2022 A small proportion of ERalpha and GPER1 are localized to catecholaminergic terminals, suggesting that binding at these ERs alters release of catecholamines, including dopamine. Catecholamines 141-155 G protein-coupled estrogen receptor 1 Rattus norvegicus 34-39 35628613-7 2022 Additionally, catecholamine pretreatment blocked propionic acid/FFAR3 signaling via PKA-dependent activation of RGS4 in H9c2 cardiomyocytes. Catecholamines 14-27 free fatty acid receptor 3 Mus musculus 64-69 35628613-7 2022 Additionally, catecholamine pretreatment blocked propionic acid/FFAR3 signaling via PKA-dependent activation of RGS4 in H9c2 cardiomyocytes. Catecholamines 14-27 regulator of G-protein signaling 4 Mus musculus 112-116 35589612-5 2022 Here, we used immunofluorescence and western blot to show that beta1 -adrenergic receptors are localized to astrocyte inner nuclear membranes; that key adrenergic signaling partners are present in astrocyte nuclei; and that OCT3 and other catecholamine transporters are localized to astrocyte plasma and nuclear membranes. Catecholamines 239-252 OCTN3 Homo sapiens 224-228 35580792-5 2022 Furthermore, we have previously elucidated that T-lymphocytes generate their own catecholamines, and strong associations exist between tyrosine hydroxylase (TH; the rate-limiting enzyme in the synthesis of catecholamines) and pro-inflammatory interleukin 17A (IL-17A) expression within purified T-lymphocytes in a rodent model of psychological trauma. Catecholamines 81-95 interleukin 17A Homo sapiens 243-258 35580792-5 2022 Furthermore, we have previously elucidated that T-lymphocytes generate their own catecholamines, and strong associations exist between tyrosine hydroxylase (TH; the rate-limiting enzyme in the synthesis of catecholamines) and pro-inflammatory interleukin 17A (IL-17A) expression within purified T-lymphocytes in a rodent model of psychological trauma. Catecholamines 81-95 interleukin 17A Homo sapiens 260-266 35580792-5 2022 Furthermore, we have previously elucidated that T-lymphocytes generate their own catecholamines, and strong associations exist between tyrosine hydroxylase (TH; the rate-limiting enzyme in the synthesis of catecholamines) and pro-inflammatory interleukin 17A (IL-17A) expression within purified T-lymphocytes in a rodent model of psychological trauma. Catecholamines 206-220 interleukin 17A Homo sapiens 243-258 35580792-5 2022 Furthermore, we have previously elucidated that T-lymphocytes generate their own catecholamines, and strong associations exist between tyrosine hydroxylase (TH; the rate-limiting enzyme in the synthesis of catecholamines) and pro-inflammatory interleukin 17A (IL-17A) expression within purified T-lymphocytes in a rodent model of psychological trauma. Catecholamines 206-220 interleukin 17A Homo sapiens 260-266 35622651-9 2022 Cardiac immunohistochemistry revealed an LV upregulation of FGF-23 in the catecholamine groups, and this improved in low-dose propranolol groups. Catecholamines 74-87 fibroblast growth factor 23 Rattus norvegicus 60-66 35622651-10 2022 These results suggest catecholamine-induced heart failure initiates early pre-fibrotic pathways through FGF-23 upregulation. Catecholamines 22-35 fibroblast growth factor 23 Rattus norvegicus 104-110 35189708-11 2022 CONCLUSIONS: Pregnancy may thus favor surges in plasma catecholamine and hypertensive crises through hCG-induced stimulation of epinephrine production by pheochromocytomas. Catecholamines 55-68 cathepsin G Homo sapiens 101-104 35409327-3 2022 Four weeks after kaolin injection into the cisterna magna, immunodetection of the catecholamine-synthetizing enzymes TH and dopamine-beta-hydroxylase (DBH) was performed in the LC and spinal cord. Catecholamines 82-95 tyrosine hydroxylase Rattus norvegicus 117-119 35241492-10 2022 Disruption of ClC-3 impairs catecholamine accumulation and secretory vesicle priming. Catecholamines 28-41 chloride voltage-gated channel 3 Homo sapiens 14-19 35391571-1 2022 Dopamine (DA), epinephrine (EP), and norepinephrine (NEP) are the main catecholamine of clinical interest, as they play crucial roles in the regulation of nervous and cardiovascular systems and are involved in some brain behaviors, such as stress, panic, anxiety, and depression. Catecholamines 71-84 epiregulin Homo sapiens 28-30 35474805-2 2022 Once lipolysis is stimulated by catecholamines, protein kinase A (PKA)-mediated phosphorylation enables the dissociation of the CGI-58/PLIN1 complex, thereby recruiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to initiate fatty acid release. Catecholamines 32-46 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase Homo sapiens 128-134 35474805-2 2022 Once lipolysis is stimulated by catecholamines, protein kinase A (PKA)-mediated phosphorylation enables the dissociation of the CGI-58/PLIN1 complex, thereby recruiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to initiate fatty acid release. Catecholamines 32-46 perilipin 1 Homo sapiens 135-140 35474805-2 2022 Once lipolysis is stimulated by catecholamines, protein kinase A (PKA)-mediated phosphorylation enables the dissociation of the CGI-58/PLIN1 complex, thereby recruiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to initiate fatty acid release. Catecholamines 32-46 patatin like phospholipase domain containing 2 Homo sapiens 169-196 35474805-2 2022 Once lipolysis is stimulated by catecholamines, protein kinase A (PKA)-mediated phosphorylation enables the dissociation of the CGI-58/PLIN1 complex, thereby recruiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to initiate fatty acid release. Catecholamines 32-46 patatin like phospholipase domain containing 2 Homo sapiens 198-202 35474805-2 2022 Once lipolysis is stimulated by catecholamines, protein kinase A (PKA)-mediated phosphorylation enables the dissociation of the CGI-58/PLIN1 complex, thereby recruiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to initiate fatty acid release. Catecholamines 32-46 lipase E, hormone sensitive type Homo sapiens 208-232 35474805-2 2022 Once lipolysis is stimulated by catecholamines, protein kinase A (PKA)-mediated phosphorylation enables the dissociation of the CGI-58/PLIN1 complex, thereby recruiting adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) to initiate fatty acid release. Catecholamines 32-46 lipase E, hormone sensitive type Homo sapiens 234-237 35409327-3 2022 Four weeks after kaolin injection into the cisterna magna, immunodetection of the catecholamine-synthetizing enzymes TH and dopamine-beta-hydroxylase (DBH) was performed in the LC and spinal cord. Catecholamines 82-95 dopamine beta-hydroxylase Rattus norvegicus 124-149 35323624-6 2022 High-level glucose reduced the expression levels of PI3K/Akt, beta1-adrenoceptors, Gs-protein, and PKA, suggesting their involvement in the protective effects of high-level glucose against toxic effects of catecholamine. Catecholamines 206-219 AKT serine/threonine kinase 1 Homo sapiens 57-60 35045722-0 2022 DPP4 (Dipeptidyl Peptidase-4) Inhibition Increases Catecholamines Without Increasing Blood Pressure During Sustained ACE (Angiotensin-Converting Enzyme) Inhibitor Treatment. Catecholamines 51-65 dipeptidyl peptidase 4 Homo sapiens 0-4 35045722-0 2022 DPP4 (Dipeptidyl Peptidase-4) Inhibition Increases Catecholamines Without Increasing Blood Pressure During Sustained ACE (Angiotensin-Converting Enzyme) Inhibitor Treatment. Catecholamines 51-65 dipeptidyl peptidase 4 Homo sapiens 6-28 35045722-8 2022 CONCLUSIONS: Increased catecholamines during concurrent ACE and DPP4 inhibition may contribute to cardiovascular complications in patients predisposed to heart failure. Catecholamines 23-37 angiotensin I converting enzyme Homo sapiens 56-59 35045722-8 2022 CONCLUSIONS: Increased catecholamines during concurrent ACE and DPP4 inhibition may contribute to cardiovascular complications in patients predisposed to heart failure. Catecholamines 23-37 dipeptidyl peptidase 4 Homo sapiens 64-68 35323624-8 2022 High-level glucose may protect cardiomyocytes from the toxic effects of catecholamine excess through suppressing beta1-adrenoceptor-Gs-PKA signaling. Catecholamines 72-85 adrenoceptor beta 1 Homo sapiens 113-131 35210363-6 2022 1) Interleukin-4 receptor deficiency impeded the alternative activation of macrophages, reduced sympathetic activity, and restrained WAT browning, and 2) reduced catecholamine synthesis in peripheral dopamine beta-hydroxylase (DBH)-deficient mice prevented cancer-induced WAT browning and adipose atrophy. Catecholamines 162-175 dopamine beta hydroxylase Mus musculus 200-225 35284140-6 2022 In addition, despite no significant correlations between plasma levels of NGF and catecholamines in both groups, urinary NGF significantly correlated positively with both urinary noradrenaline and urinary adrenaline in the hypertensive group (r = 0.259, p=0.018 and r = 0.232, p=0.035), but not in the normotensive group (r = 0.115, p=0.307 and r = -0.018, p=0.871). Catecholamines 82-96 nerve growth factor Homo sapiens 121-124 35210363-6 2022 1) Interleukin-4 receptor deficiency impeded the alternative activation of macrophages, reduced sympathetic activity, and restrained WAT browning, and 2) reduced catecholamine synthesis in peripheral dopamine beta-hydroxylase (DBH)-deficient mice prevented cancer-induced WAT browning and adipose atrophy. Catecholamines 162-175 dopamine beta hydroxylase Mus musculus 227-230 35195486-0 2022 Influence of Timing and Catecholamine Requirements on Vasopressin Responsiveness in Critically ill Patients with Septic Shock. Catecholamines 24-37 arginine vasopressin Homo sapiens 54-65 35213289-3 2022 In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP responses to beta-blockers. Catecholamines 92-105 aminoacylase 3 Homo sapiens 127-131 35226170-2 2022 This study was done to evaluate the levels of catecholamines in skin and plasma samples of active vitiligo patients" and gene expression changes in catecholamines" metabolism regulatory genes (COMT and GTPCH1), immunoregulatory genes (CTLA4 and PTPN22), and Catalase in active vitiligo patients. Catecholamines 148-162 catechol-O-methyltransferase Homo sapiens 193-197 35226170-2 2022 This study was done to evaluate the levels of catecholamines in skin and plasma samples of active vitiligo patients" and gene expression changes in catecholamines" metabolism regulatory genes (COMT and GTPCH1), immunoregulatory genes (CTLA4 and PTPN22), and Catalase in active vitiligo patients. Catecholamines 148-162 GTP cyclohydrolase 1 Homo sapiens 202-208 35226170-2 2022 This study was done to evaluate the levels of catecholamines in skin and plasma samples of active vitiligo patients" and gene expression changes in catecholamines" metabolism regulatory genes (COMT and GTPCH1), immunoregulatory genes (CTLA4 and PTPN22), and Catalase in active vitiligo patients. Catecholamines 148-162 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 245-251 35226170-2 2022 This study was done to evaluate the levels of catecholamines in skin and plasma samples of active vitiligo patients" and gene expression changes in catecholamines" metabolism regulatory genes (COMT and GTPCH1), immunoregulatory genes (CTLA4 and PTPN22), and Catalase in active vitiligo patients. Catecholamines 148-162 catalase Homo sapiens 258-266 35195486-2 2022 Methods: This multicenter retrospective cohort study conducted in critically ill adults sought to evaluate the role of catecholamine requirements and timing on responsiveness to AVP. Catecholamines 119-132 arginine vasopressin Homo sapiens 178-181 35124671-3 2022 Psychological stress leads to an increase of serum glucocorticoid concentrations and catecholamines release increasing the insulin need and the insulin resistance. Catecholamines 85-99 insulin Homo sapiens 123-130 35156051-6 2022 PATIENTS: Patients with septic shock initiated on vasopressin as a catecholamine adjunct between January 2012 and November 2017 were screened for inclusion. Catecholamines 67-80 arginine vasopressin Homo sapiens 50-61 35156051-11 2022 For each 0.1 unit the pH was below 7.40 at vasopressin initiation, the norepinephrine-equivalent catecholamine dose increased by 1.5 microg/min (95% CI, 0.5-2.5 microg/min) at 1 hour, and increased by 2.5 microg/min (95% CI, 1.4-3.5 microg/min) at 6 hours after vasopressin initiation. Catecholamines 97-110 arginine vasopressin Homo sapiens 43-54 35156051-11 2022 For each 0.1 unit the pH was below 7.40 at vasopressin initiation, the norepinephrine-equivalent catecholamine dose increased by 1.5 microg/min (95% CI, 0.5-2.5 microg/min) at 1 hour, and increased by 2.5 microg/min (95% CI, 1.4-3.5 microg/min) at 6 hours after vasopressin initiation. Catecholamines 97-110 arginine vasopressin Homo sapiens 262-273 35156051-12 2022 CONCLUSIONS: Compared with higher arterial pH, patients with septic shock and low arterial pH had lower odds of vasopressin response and higher catecholamine doses after vasopressin initiation. Catecholamines 144-157 arginine vasopressin Homo sapiens 170-181 35124671-3 2022 Psychological stress leads to an increase of serum glucocorticoid concentrations and catecholamines release increasing the insulin need and the insulin resistance. Catecholamines 85-99 insulin Homo sapiens 144-151 35073310-0 2022 Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells. Catecholamines 22-36 toll-like receptor 9 Mus musculus 72-76 33092667-4 2022 Anxiolytic pherines could activate the forward inhibitory GABAergic neurons that facilitate the release of neuropeptide S (NPS) in the locus coeruleus (LC) and GABA in the bed nucleus of the stria terminalis (BNST) and inhibit catecholamine release in the LC and ventral tegmental area (VTA) leading to rapid anxiolytic effect. Catecholamines 227-240 neuropeptide S Homo sapiens 107-121 35169262-3 2022 We found that most of these variants resulted either in a lower abundance or a partial impairment in one of the basic functions of CADPS in regulating neuronal exocytosis, synaptic plasticity and vesicular transporter-dependent uptake of catecholamines. Catecholamines 238-252 calcium dependent secretion activator Homo sapiens 131-136 35073310-3 2022 In this study, we investigated the ability of B cells to synthesize their own catecholamines upon stimulation with different B cell activators and found that expression of the enzyme tyrosine hydroxylase (TH), required to generate catecholamines, is up-regulated by Toll-like receptor (TLR)9. Catecholamines 78-92 tyrosine hydroxylase Mus musculus 183-203 35073310-3 2022 In this study, we investigated the ability of B cells to synthesize their own catecholamines upon stimulation with different B cell activators and found that expression of the enzyme tyrosine hydroxylase (TH), required to generate catecholamines, is up-regulated by Toll-like receptor (TLR)9. Catecholamines 78-92 tyrosine hydroxylase Mus musculus 205-207 35073310-3 2022 In this study, we investigated the ability of B cells to synthesize their own catecholamines upon stimulation with different B cell activators and found that expression of the enzyme tyrosine hydroxylase (TH), required to generate catecholamines, is up-regulated by Toll-like receptor (TLR)9. Catecholamines 78-92 toll-like receptor 9 Mus musculus 266-291 35073310-3 2022 In this study, we investigated the ability of B cells to synthesize their own catecholamines upon stimulation with different B cell activators and found that expression of the enzyme tyrosine hydroxylase (TH), required to generate catecholamines, is up-regulated by Toll-like receptor (TLR)9. Catecholamines 231-245 tyrosine hydroxylase Mus musculus 183-203 35073310-3 2022 In this study, we investigated the ability of B cells to synthesize their own catecholamines upon stimulation with different B cell activators and found that expression of the enzyme tyrosine hydroxylase (TH), required to generate catecholamines, is up-regulated by Toll-like receptor (TLR)9. Catecholamines 231-245 tyrosine hydroxylase Mus musculus 205-207 35046103-1 2022 OBJECTIVE: This study aimed to reveal the clinical characteristics of patients with severe Takotsubo syndrome (TTS) who needed catecholamine support (CS) or mechanical support (MS) and to identify factors associated with serious illness and in-hospital mortality. Catecholamines 127-140 citrate synthase Homo sapiens 150-152 35066506-1 2022 BACKGROUND: Selenoprotein T (SELENOT), a PACAP-regulated thioredoxin-like protein, plays a role in catecholamine secretion and protects dopaminergic neurons. Catecholamines 99-112 selenoprotein T Mus musculus 12-27 35066506-1 2022 BACKGROUND: Selenoprotein T (SELENOT), a PACAP-regulated thioredoxin-like protein, plays a role in catecholamine secretion and protects dopaminergic neurons. Catecholamines 99-112 selenoprotein T Mus musculus 29-36 35072084-0 2022 Effectiveness of Angiotensin II for Catecholamine Refractory Septic or Distributive Shock on Mortality: A Propensity Score Weighted Analysis of Real-World Experience in the Medical ICU. Catecholamines 36-49 angiotensinogen Homo sapiens 17-31 35044787-6 2022 Bag5 mutant knock-in mice exhibited ventricular dilatation, arrhythmogenicity, and poor prognosis under catecholamine stimulation, recapitulating the human DCM phenotype, and administration of an adeno-associated virus 9 vector carrying the wild-type BAG5 gene could fully ameliorate these DCM phenotypes. Catecholamines 104-117 BCL2-associated athanogene 5 Mus musculus 0-4 35044787-8 2022 Bag5-mutant mouse cardiomyocytes exhibited decreased abundance of functional JMC proteins under catecholamine stimulation, disrupted JMC structure, and calcium handling abnormalities. Catecholamines 96-109 BCL2-associated athanogene 5 Mus musculus 0-4 35070058-11 2022 CONCLUSION: High doses of catecholamines exert insulin-like actions on glucose transport in human adipocytes. Catecholamines 26-40 insulin Homo sapiens 47-54 34847077-0 2022 beta3-adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. Catecholamines 60-73 adrenergic receptor, beta 3 Mus musculus 0-25 34847077-5 2022 beta3-adrenergic receptor downregulation also occurs after high fat diet feeding, concurrent with catecholamine resistance and elevated inflammation. Catecholamines 98-111 adrenergic receptor, beta 3 Mus musculus 0-25 34847077-9 2022 EPAC/RAP inhibition enhanced catecholamine-stimulated lipolysis and energy expenditure in obese mice. Catecholamines 29-42 Rap guanine nucleotide exchange factor (GEF) 3 Mus musculus 0-4 34847077-9 2022 EPAC/RAP inhibition enhanced catecholamine-stimulated lipolysis and energy expenditure in obese mice. Catecholamines 29-42 low density lipoprotein receptor-related protein associated protein 1 Mus musculus 5-8 35058750-7 2021 Brain FXR activation decreases the rate-limiting enzyme in catecholamine synthesis, tyrosine hydroxylase (TH), and consequently the sympathetic tone. Catecholamines 59-72 nuclear receptor subfamily 1, group H, member 4 Mus musculus 6-9 35013193-1 2022 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Catecholamines 106-120 tyrosine hydroxylase Homo sapiens 0-20 35013193-1 2022 Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Catecholamines 106-120 tyrosine hydroxylase Homo sapiens 22-24 35013193-2 2022 Inhibition by catecholamines and reactivation by S40 phosphorylation are key regulatory mechanisms of TH activity and conformational stability. Catecholamines 14-28 tyrosine hydroxylase Homo sapiens 102-104 35058750-7 2021 Brain FXR activation decreases the rate-limiting enzyme in catecholamine synthesis, tyrosine hydroxylase (TH), and consequently the sympathetic tone. Catecholamines 59-72 tyrosine hydroxylase Mus musculus 106-108 35381093-2 2022 Chromogranin A (CgA) and peptide proSAAS belong to the family of granins and are present in neuroendocrine cells of adrenal medulla, from where they are released to circulation, along with catecholamines. Catecholamines 189-203 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 33-40 35046893-0 2021 Electroacupuncture Stimulation Regulates Adipose Lipolysis via Catecholamine Signaling Mediated by NLRP3 Suppression in Obese Rats. Catecholamines 63-76 NLR family, pyrin domain containing 3 Rattus norvegicus 99-104 34842277-1 2022 BACKGROUND: Recent reports indicate that Parkinson"s disease (PD) involves specific functional abnormalities in residual neurons-decreased vesicular sequestration of cytoplasmic catecholamines via the vesicular monoamine transporter (VMAT) and decreased aldehyde dehydrogenase (ALDH) activity. Catecholamines 178-192 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 278-282 34865027-2 2022 Chronic fetal hypoxemia elevates circulating catecholamines, which reduces skeletal muscle beta2 adrenoceptor content and contributes to growth and metabolic pathologies in IUGR-born offspring. Catecholamines 45-59 adrenoceptor beta 2 Homo sapiens 91-109 35085004-10 2022 Finally, a strong MYCN and weak dopamine beta-hydroxylase staining of tumors derived from patients with elevated urinary 3MT levels was observed, linking MYC activity in the tumor to both catecholamine biosynthesis and elevated urinary 3MT levels. Catecholamines 188-201 MYC proto-oncogene, bHLH transcription factor Homo sapiens 154-157