PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 27896073-7 2014 MCT administration can provide energy to hepatocytes and was expected to have a good effect on CTLN2. mct 0-3 solute carrier family 25 member 13 Homo sapiens 95-100 23727642-9 2013 In addition, plasma insulin concentration, liver phosphorylated Akt/Akt and phosphorylated mTOR/mTOR levels were significantly higher in the MCT-fed group than in the LCT-fed group. mct 141-144 insulin Homo sapiens 20-27 23525442-10 2013 In vivo, RAGE inhibition in monocrotaline- and Sugen-induced PAH demonstrates therapeutic effects characterized by PA pressure and right ventricular hypertrophy decrease (control rats have an mPAP around 15 mm Hg, PAH rats have an mPAP >40 mm Hg, and with RAGE inhibition, mPAP decreases to 20 and 28 mm Hg, respectively, in MCT and Sugen models). mct 328-331 advanced glycosylation end product-specific receptor Rattus norvegicus 9-13 23727642-9 2013 In addition, plasma insulin concentration, liver phosphorylated Akt/Akt and phosphorylated mTOR/mTOR levels were significantly higher in the MCT-fed group than in the LCT-fed group. mct 141-144 AKT serine/threonine kinase 1 Rattus norvegicus 64-67 23727642-9 2013 In addition, plasma insulin concentration, liver phosphorylated Akt/Akt and phosphorylated mTOR/mTOR levels were significantly higher in the MCT-fed group than in the LCT-fed group. mct 141-144 AKT serine/threonine kinase 1 Rattus norvegicus 68-71 23727642-9 2013 In addition, plasma insulin concentration, liver phosphorylated Akt/Akt and phosphorylated mTOR/mTOR levels were significantly higher in the MCT-fed group than in the LCT-fed group. mct 141-144 mechanistic target of rapamycin kinase Rattus norvegicus 91-95 23727642-9 2013 In addition, plasma insulin concentration, liver phosphorylated Akt/Akt and phosphorylated mTOR/mTOR levels were significantly higher in the MCT-fed group than in the LCT-fed group. mct 141-144 mechanistic target of rapamycin kinase Rattus norvegicus 96-100 21658367-3 2011 We now report the involvement of TF in the release of retinoid receptors RAR-alpha and RXR-alpha as accumulated lipid droplet during monocrotaline/lipopolysaccharide (MCT/LPS)-liver injury. mct 167-170 coagulation factor III, tissue factor Homo sapiens 33-35 22270906-3 2012 The aim of this study was to investigate whether a polymorphism in the FABP2 promoter does affect the metabolic response to either an medium-chain triacylglycerol (MCT) or an long-chain triacylglycerol (LCT) diet, which were suggested to differ in transport mechanisms, in affinity to FABP2, in activating transcription factors binding to the FABP2 promoter and in their effects on insulin sensitivity. mct 164-167 fatty acid binding protein 2 Homo sapiens 71-76 21658367-3 2011 We now report the involvement of TF in the release of retinoid receptors RAR-alpha and RXR-alpha as accumulated lipid droplet during monocrotaline/lipopolysaccharide (MCT/LPS)-liver injury. mct 167-170 retinoic acid receptor alpha Homo sapiens 73-82 21658367-3 2011 We now report the involvement of TF in the release of retinoid receptors RAR-alpha and RXR-alpha as accumulated lipid droplet during monocrotaline/lipopolysaccharide (MCT/LPS)-liver injury. mct 167-170 retinoid X receptor alpha Homo sapiens 87-96 19656485-2 2009 Work in genetically modified mice (Kirchner et al., 2009) now shows that in vivo activity of ghrelin O-acyltransferase (GOAT), responsible for ghrelin octanoylation, decreases during fasting but increases after ingesting medium-chain fatty acid triglycerides (MCT). mct 260-263 membrane bound O-acyltransferase domain containing 4 Mus musculus 93-118 11350261-3 2001 The present study was performed to compare the effect of long chain triglycerides (LCT, corn oil), very long chain triglycerides (VLCT, fish oil) and medium chain triglycerides (MCT) on SMA flow. mct 178-181 survival of motor neuron 1, telomeric Homo sapiens 186-189 19710535-1 2009 BACKGROUND: We investigated whether (1) monocrotaline(MCT)-induced right ventricular (RV) dilatation is associated with re-expression of myocardial tenascin-C (TNC), (2) elevated plasma TNC levels can be used as a marker of ventricular dilatation, and (3) MCT-induced RV dilatation is associated with alterations of other remodeling-related proteins. mct 54-57 tenascin C Rattus norvegicus 148-158 11602676-9 2001 After the rats were switched to palm oil or MCT, there was marked histological improvement with decreased levels of endotoxin and lipid peroxidation, absence of NF-kappaB activation, and reduced expression of TNF-alpha and Cox-2. mct 44-47 tumor necrosis factor Rattus norvegicus 209-218 11602676-9 2001 After the rats were switched to palm oil or MCT, there was marked histological improvement with decreased levels of endotoxin and lipid peroxidation, absence of NF-kappaB activation, and reduced expression of TNF-alpha and Cox-2. mct 44-47 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 223-228 8770048-4 1996 On the other hand, portal FFA and apo A-IV transports increased at 15 min after MCT infusion but not after LCT infusion. mct 80-83 apolipoprotein A4 Rattus norvegicus 34-42 10069039-3 1999 Among dietary fat sources, medium-chain triacylglycerol (MCT) was a potent stimulator of CCK release compared with long-chain triacylglycerol (LCT). mct 57-60 cholecystokinin Gallus gallus 89-92 8510520-2 1993 The objective of this study was to test the hypothesis that parenteral LCT require more extensive modification via hydrolysis and reesterification (triglyceride-free fatty acid [TG-FFA] recycling) for effective utilization, whereas MCT and SL do not. mct 232-235 lactase Rattus norvegicus 71-74 8505832-4 1993 There was an eightfold increase in plasma beta-hydroxybutyrate and acetoacetate concentrations and a threefold increase in serum insulin levels during MCT/LCT infusion, but no significant change in ketone bodies and insulin from basal values was observed during and after Sb infusion. mct 151-154 insulin Homo sapiens 129-136 1601800-1 1992 On the basis of the previous findings that alpha-difluoromethylornithine (DFMO, an inhibitor of ornithine decarboxylase, which is the rate-limiting enzyme in polyamine biosynthesis) treatment prevents monocrotaline-(MCT) induced pulmonary hypertension and that ventilatory dysfunction precedes pulmonary hypertension in MCT-treated rats, we hypothesize that MCT-induced changes in airway/lung function are polyamine dependent. mct 216-219 ornithine decarboxylase 1 Rattus norvegicus 96-119 1568535-1 1992 Dietary medium-chain triglycerides (MCT) may improve insulin-mediated glucose metabolism. mct 36-39 insulin Homo sapiens 53-60 1601800-1 1992 On the basis of the previous findings that alpha-difluoromethylornithine (DFMO, an inhibitor of ornithine decarboxylase, which is the rate-limiting enzyme in polyamine biosynthesis) treatment prevents monocrotaline-(MCT) induced pulmonary hypertension and that ventilatory dysfunction precedes pulmonary hypertension in MCT-treated rats, we hypothesize that MCT-induced changes in airway/lung function are polyamine dependent. mct 320-323 ornithine decarboxylase 1 Rattus norvegicus 96-119 1601800-1 1992 On the basis of the previous findings that alpha-difluoromethylornithine (DFMO, an inhibitor of ornithine decarboxylase, which is the rate-limiting enzyme in polyamine biosynthesis) treatment prevents monocrotaline-(MCT) induced pulmonary hypertension and that ventilatory dysfunction precedes pulmonary hypertension in MCT-treated rats, we hypothesize that MCT-induced changes in airway/lung function are polyamine dependent. mct 320-323 ornithine decarboxylase 1 Rattus norvegicus 96-119 34466786-2 2021 In this study, we found that medium-chain triglycerides (MCTs) inhibit GIP secretion after single LCT ingestion and clarified the mechanism underlying MCT-induced inhibition of GIP secretion. mct 151-154 gastric inhibitory polypeptide Mus musculus 71-74 34676402-6 2021 Intratracheal injection of adeno-associated virus serotype 1 carrying xbp1s shRNA (AAV-xbp1s) to knock down the expression of xbp1s effectively ameliorated the MCT-induced elevation of right ventricular systolic pressure (RVSP), total pulmonary resistance (TPR), right ventricular hypertrophy and medial wall thickness of muscularized distal pulmonary arterioles. mct 160-163 X-box binding protein 1 Homo sapiens 70-74 1778219-5 1991 MCT/LCT infusion resulted in higher plasma levels at steady-state of TG (3.63 +/- 0.45 [SEM] vs 2.73 +/- 0.45 mmol l-1; P less than 0.05), FFA (1.05 +/- 0.08 vs 0.54 +/- 0.04 mmol l-1; P less than 0.01) and LPL (4.6 +/- 0.6 vs 2.6 +/- 0.5 mU ml-1; P less than 0.05) in comparison with LCT administration. mct 0-3 lipoprotein lipase Homo sapiens 207-210 2325241-4 1990 Mitogen-stimulated and IL-2 activated human lymphocyte proliferation were both inhibited in a dose-dependent manner in the presence of all three lipid emulsions although the effects were less marked with the solution in which 50% of the calories are present as medium-chain triglycerides (MCT) rather than long-chain triglycerides (LCT). mct 289-292 interleukin 2 Homo sapiens 23-27 34466786-2 2021 In this study, we found that medium-chain triglycerides (MCTs) inhibit GIP secretion after single LCT ingestion and clarified the mechanism underlying MCT-induced inhibition of GIP secretion. mct 151-154 gastric inhibitory polypeptide Mus musculus 177-180 34466786-3 2021 MCTs reduced the CCK effect after single LCT ingestion in wild-type (WT) mice, and a CCK agonist completely reversed MCT-induced inhibition of GIP secretion. mct 117-120 cholecystokinin Mus musculus 85-88 34466786-3 2021 MCTs reduced the CCK effect after single LCT ingestion in wild-type (WT) mice, and a CCK agonist completely reversed MCT-induced inhibition of GIP secretion. mct 117-120 gastric inhibitory polypeptide Mus musculus 143-146 34466786-6 2021 Thus, MCT-induced inhibition of GIP hypersecretion reduces obesity and insulin resistance under high-LCT diet feeding condition. mct 6-9 gastric inhibitory polypeptide Mus musculus 32-35 35222742-8 2022 These results indicate that Shufeiya Recipe can improve MCT-induced pulmonary hypertension in rats by regulating SIRT3/FOXO3a and its downstream PI3K/AKT/eNOS and Ras/ERK signaling pathways. mct 56-59 sirtuin 3 Rattus norvegicus 113-118 35531709-5 2022 The static binding capacity (SBC) for BSA was 79.7 +- 1.3 mg/g and 92.9 +- 8.2 mg/g for PVAm-modified and PVAm-MCT-beta-CD-modified fabrics, respectively. mct 111-114 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 115-122 35531709-7 2022 SBC for lysozyme and toluidine blue O (TBO, a basic dye) onto PVAm-MCT-beta-CD functionalized PET was 52.7 +- 5.1 mg/g and 73.3 +- 0.6 mg/g, respectively. mct 67-70 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 71-78 35222742-8 2022 These results indicate that Shufeiya Recipe can improve MCT-induced pulmonary hypertension in rats by regulating SIRT3/FOXO3a and its downstream PI3K/AKT/eNOS and Ras/ERK signaling pathways. mct 56-59 forkhead box O3 Rattus norvegicus 119-125 35222742-8 2022 These results indicate that Shufeiya Recipe can improve MCT-induced pulmonary hypertension in rats by regulating SIRT3/FOXO3a and its downstream PI3K/AKT/eNOS and Ras/ERK signaling pathways. mct 56-59 AKT serine/threonine kinase 1 Rattus norvegicus 150-153 35222742-8 2022 These results indicate that Shufeiya Recipe can improve MCT-induced pulmonary hypertension in rats by regulating SIRT3/FOXO3a and its downstream PI3K/AKT/eNOS and Ras/ERK signaling pathways. mct 56-59 nitric oxide synthase 3 Rattus norvegicus 154-158 35222742-8 2022 These results indicate that Shufeiya Recipe can improve MCT-induced pulmonary hypertension in rats by regulating SIRT3/FOXO3a and its downstream PI3K/AKT/eNOS and Ras/ERK signaling pathways. mct 56-59 mitogen activated protein kinase 3 Rattus norvegicus 167-170 3369689-7 1988 MCT-Sepharose and benzylthio-Sepharose provide rapid and convenient one-step procedures for obtaining purified cytosolic epoxide hydrolase from numerous species and tissues. mct 0-3 epoxide hydrolase 2, cytoplasmic Mus musculus 111-138 2731160-3 1989 Since the TNF-induced weight loss was accompanied by hypophagia and a concomitant hypoglycaemia we attempted to reverse the weight loss by force-feeding either glucose or medium chain-triglycerides (MCT). mct 199-202 tumor necrosis factor Mus musculus 10-13 6695835-1 1984 The present study was undertaken to compare the effects of equimolar amounts of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) on plasma cholecystokinin (CCK) concentrations and gallbladder contraction in man. mct 143-146 cholecystokinin Homo sapiens 175-178 32740958-8 2021 Medium-chain triglyceride (MCT) supplementation with a lactose-restricted formula and MCT supplementation under a low-carbohydrate diet are recommended for NICCD and CTLN2, respectively. mct 27-30 solute carrier family 25 member 13 Homo sapiens 166-171 33613315-10 2021 The inhibition of ROCK by Y-27632 attenuated the sensitivity to U46619 in both control and PAH-MCT. mct 95-98 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 18-22 33574976-5 2021 In addition, aerosolized CSNO significantly inhibited the hyperactivation of signal transducers and activators of transduction 3 (STAT3) and extracellular regulated protein kinases (ERK) pathways in the lung of MCT-induced rats. mct 211-214 signal transducer and activator of transcription 3 Rattus norvegicus 77-128 33574976-5 2021 In addition, aerosolized CSNO significantly inhibited the hyperactivation of signal transducers and activators of transduction 3 (STAT3) and extracellular regulated protein kinases (ERK) pathways in the lung of MCT-induced rats. mct 211-214 signal transducer and activator of transcription 3 Rattus norvegicus 130-135 33574976-5 2021 In addition, aerosolized CSNO significantly inhibited the hyperactivation of signal transducers and activators of transduction 3 (STAT3) and extracellular regulated protein kinases (ERK) pathways in the lung of MCT-induced rats. mct 211-214 Eph receptor B1 Rattus norvegicus 141-180 33574976-5 2021 In addition, aerosolized CSNO significantly inhibited the hyperactivation of signal transducers and activators of transduction 3 (STAT3) and extracellular regulated protein kinases (ERK) pathways in the lung of MCT-induced rats. mct 211-214 Eph receptor B1 Rattus norvegicus 182-185 33152351-4 2021 METHODS: mRNA, and protein levels of IRF7 were assessed in the lung samples and isolated pulmonary artery smooth muscle cells (PASMCs) from MCT-induced PH in rats. mct 140-143 interferon regulatory factor 7 Rattus norvegicus 37-41 33152351-7 2021 RESULTS: mRNA and protein levels of IRF7 were decreased in vivo and in vitro in the pulmonary vascular from MCT induced PH rats. mct 108-111 interferon regulatory factor 7 Rattus norvegicus 36-40 33053685-6 2020 Compared with the NC treatment, the MCT treatment significantly increased the level of claudin-1, Zonula occludens-1(ZO-1), while the GML treatment significantly increased the level of claudin-1, occludin, ZO-1 (p < 0.05). mct 36-39 claudin 1 Homo sapiens 87-96 33448436-5 2020 In mice fed either MCT or triheptanoin, succinate and malate were greater in VLCAD-/- mice fed triheptanoin compared to VLCAD-/- animals fed MCT but lower than WT mice fed triheptanoin. mct 19-22 acyl-Coenzyme A dehydrogenase, very long chain Mus musculus 77-82 33053685-6 2020 Compared with the NC treatment, the MCT treatment significantly increased the level of claudin-1, Zonula occludens-1(ZO-1), while the GML treatment significantly increased the level of claudin-1, occludin, ZO-1 (p < 0.05). mct 36-39 tight junction protein 1 Homo sapiens 117-121 31394165-2 2019 Long-term treatment with MCT led to a sexually dimorphic response in the mouse model of very-long-chain-acyl-CoA-dehydrogenase-deficiency (VLCAD-/-) with the subsequent development of a metabolic syndrome in female mice. mct 25-28 acyl-Coenzyme A dehydrogenase, very long chain Mus musculus 139-144 30588060-5 2018 Patients with CTLN2 required liver transplantation for the most promising prognosis; however, they were successfully treated with MCT supplement with a low carbohydrate formula. mct 130-133 solute carrier family 25 member 13 Homo sapiens 14-19 31017016-6 2019 In addition, pulmonary hypertension can be treated in MCT-PAH rats by administering a selective Cat S inhibitor, Millipore-219393, which stimulates peroxisome proliferator-activated receptor-gamma (PPARgamma) to inhibit the expression of Cat S, thus suppressing the proliferation and migration of MCT-PAH PASMCs. mct 54-57 cathepsin S Homo sapiens 96-101 31017016-6 2019 In addition, pulmonary hypertension can be treated in MCT-PAH rats by administering a selective Cat S inhibitor, Millipore-219393, which stimulates peroxisome proliferator-activated receptor-gamma (PPARgamma) to inhibit the expression of Cat S, thus suppressing the proliferation and migration of MCT-PAH PASMCs. mct 54-57 peroxisome proliferator-activated receptor gamma Rattus norvegicus 148-196 31017016-6 2019 In addition, pulmonary hypertension can be treated in MCT-PAH rats by administering a selective Cat S inhibitor, Millipore-219393, which stimulates peroxisome proliferator-activated receptor-gamma (PPARgamma) to inhibit the expression of Cat S, thus suppressing the proliferation and migration of MCT-PAH PASMCs. mct 54-57 peroxisome proliferator-activated receptor gamma Rattus norvegicus 198-207 31017016-6 2019 In addition, pulmonary hypertension can be treated in MCT-PAH rats by administering a selective Cat S inhibitor, Millipore-219393, which stimulates peroxisome proliferator-activated receptor-gamma (PPARgamma) to inhibit the expression of Cat S, thus suppressing the proliferation and migration of MCT-PAH PASMCs. mct 54-57 cathepsin S Homo sapiens 238-243 30171047-8 2018 In a trial of dogs with MCT, D1/D2 dosing of HSP90i was associated with sustained KIT downregulation, 50% objective response rate and 100% clinical benefit rate compared with D1 and D1/D4 schedules. mct 24-27 deiodinase, iodothyronine, type I Mus musculus 29-34 29597044-3 2018 The aim of this work was to study the absorption and transport mechanism across the intestinal barrier of new R-ALA stable and water soluble form, consisting in the lysine R-ALA salt, in presence and absence of specific inhibitors of Na+/multivitamin (SMVT) and monocarboxylic acids (MCT). mct 284-287 RAS like proto-oncogene A Rattus norvegicus 110-115 29969608-14 2018 SIGNIFICANCE: Baicalein attenuated MCT-induced PAH in rats by inhibiting EndoMT partially via the NF-kappaB-BMPR2 pathway. mct 35-38 bone morphogenetic protein receptor type 2 Rattus norvegicus 108-113 29651749-5 2018 We previously reported that medium-chain triglyceride (MCT) supplement therapy with a low-carbohydrate formula was effective in CTLN2 to prevent a relapse of hyperammonemic encephalopathy. mct 55-58 solute carrier family 25 member 13 Homo sapiens 128-133 29508680-6 2018 Furthermore, the protein expression of heat-shock protein 70 in jejunum and the concentration of TNF-alpha in plasma were reduced in the piglets fed diets supplemented with MCT. mct 173-176 heat shock 70 kDa protein 4 Zea mays 39-60 28926926-11 2017 Furthermore, aloperine also alleviated the MCT-induced changes of p27kip1, Bax and Bcl-2. mct 43-46 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 66-73 29290032-11 2018 Pharmacological inhibition of FOXM1 improves established PAH in the MCT and Su/Hx rat models. mct 68-71 forkhead box M1 Rattus norvegicus 30-35 28926926-11 2017 Furthermore, aloperine also alleviated the MCT-induced changes of p27kip1, Bax and Bcl-2. mct 43-46 BCL2 associated X, apoptosis regulator Rattus norvegicus 75-78 28926926-11 2017 Furthermore, aloperine also alleviated the MCT-induced changes of p27kip1, Bax and Bcl-2. mct 43-46 BCL2, apoptosis regulator Rattus norvegicus 83-88 28292027-4 2017 Our study showed that CLDN1 expression was markedly increased in the lungs of rats with monocrotaline(MCT)-induced PAH, especially in the pulmonary arterial smooth muscle sections. mct 102-105 claudin 1 Rattus norvegicus 22-27 28682459-1 2017 OBJECTIVE: The medium-chain triglyceride (MCT) ketogenic diet contains both octanoic (C8) and decanoic (C10) acids. mct 42-45 homeobox C10 Homo sapiens 104-107 24735404-3 2014 Thus, this new sustained release system was named PME (first letter of phospholipids, MCT, and ethanol). mct 86-89 cystatin B Homo sapiens 50-53 27420584-10 2016 TQ also blocked MCT-induced pulmonary arterial remodeling, proliferation of PASMCs, elevation of MMP2 and downregulation of ratio of Bax/Bcl-2, cleaved caspase-3 and cleaved PARP. mct 16-19 matrix metallopeptidase 2 Rattus norvegicus 97-101 27420584-10 2016 TQ also blocked MCT-induced pulmonary arterial remodeling, proliferation of PASMCs, elevation of MMP2 and downregulation of ratio of Bax/Bcl-2, cleaved caspase-3 and cleaved PARP. mct 16-19 BCL2 associated X, apoptosis regulator Rattus norvegicus 133-136 27420584-10 2016 TQ also blocked MCT-induced pulmonary arterial remodeling, proliferation of PASMCs, elevation of MMP2 and downregulation of ratio of Bax/Bcl-2, cleaved caspase-3 and cleaved PARP. mct 16-19 BCL2, apoptosis regulator Rattus norvegicus 137-142 26337118-0 2015 The adsorption of allergoids and 3-O-desacyl-4"-monophosphoryl lipid A (MPL ) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy. mct 108-111 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 72-75 26337118-11 2015 MCT formulations treated to disrupt electrostatic, hydrophobic and ligand exchange interactions, gave an MPL content of <=2 mug/mL in supernatant samples. mct 0-3 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 105-108 25197199-1 2014 Medium chain triglyceride (MCT)-based diet, total parenteral nutrition (TPN) and repeated paracentesis are considered as supportive management for congenital chylous ascites (CCA). mct 27-30 fibrillin 2 Homo sapiens 175-178