PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 9915811-2 1999 The kinetics of PI-PLCgamma1 toward a water-soluble substrate (inositol 1,2-cyclic phosphate, cIP) and phosphatidylinositol (PI) in detergent mixed micelles were monitored by 31P NMR spectroscopy. inositol cyclic phosphate 63-92 phospholipase C gamma 1 Homo sapiens 19-28 7629237-8 1995 These findings represent the first report of a naturally occurring mammalian inositol 1,2-cyclic phosphate containing phosphoglycan related to insulin action. inositol cyclic phosphate 77-106 insulin Homo sapiens 143-150 1318746-2 1992 The phosphatidylinositol-specific phospholipase C (PI-PLC) from mammalian sources catalyzes the simultaneous formation of both inositol 1,2-cyclic phosphate (IcP) and inositol 1-phosphate (IP). inositol cyclic phosphate 127-156 phospholipase C beta 1 Homo sapiens 4-49 1318746-2 1992 The phosphatidylinositol-specific phospholipase C (PI-PLC) from mammalian sources catalyzes the simultaneous formation of both inositol 1,2-cyclic phosphate (IcP) and inositol 1-phosphate (IP). inositol cyclic phosphate 127-156 phospholipase C beta 1 Homo sapiens 51-57 1318746-2 1992 The phosphatidylinositol-specific phospholipase C (PI-PLC) from mammalian sources catalyzes the simultaneous formation of both inositol 1,2-cyclic phosphate (IcP) and inositol 1-phosphate (IP). inositol cyclic phosphate 158-161 phospholipase C beta 1 Homo sapiens 4-49 1318746-2 1992 The phosphatidylinositol-specific phospholipase C (PI-PLC) from mammalian sources catalyzes the simultaneous formation of both inositol 1,2-cyclic phosphate (IcP) and inositol 1-phosphate (IP). inositol cyclic phosphate 158-161 phospholipase C beta 1 Homo sapiens 51-57 2137335-4 1990 The glycosyl-phosphatidylinositol anchor of purified human renal dipeptidase was hydrolysed by a range of bacterial PI-PLCs and by a plasma phospholipase D. Mild acid treatment and nitrous acid deamination of the hydrophilic form revealed that the cross-reacting determinant, characteristic of the glycosyl-phosphatidylinositol anchor, was due exclusively to the inositol 1,2-cyclic phosphate ring epitope. inositol cyclic phosphate 363-392 dipeptidase 1 Homo sapiens 59-76 9003188-1 1997 Three inositol 1,2-(cyclic)-phosphate analogs, inositol cyclic phosphonates with different stereochemistry at the C-2 position of the inositol ring, have been synthesized as water-soluble inhibitors of phosphatidylinositol-specific phospholipase C (PI-PLC). inositol cyclic phosphate 6-37 phospholipase C beta 1 Homo sapiens 202-247 9003188-1 1997 Three inositol 1,2-(cyclic)-phosphate analogs, inositol cyclic phosphonates with different stereochemistry at the C-2 position of the inositol ring, have been synthesized as water-soluble inhibitors of phosphatidylinositol-specific phospholipase C (PI-PLC). inositol cyclic phosphate 6-37 phospholipase C beta 1 Homo sapiens 249-255 9003188-4 1997 (i) Only the analog with the same stereochemistry at the C-2 position of the inositol ring as the natural substrate, myo-inositol 1,2-(cyclic)-phosphate (cIP), exhibits effective inhibition of PI-PLC. inositol cyclic phosphate 117-152 phospholipase C beta 1 Homo sapiens 193-199