PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33217013-11	2021	EPHX1-416G/G genotype was a significant covariate for the clearance of carbamazepine 10,11-epoxide.	10,11-epoxide	85-98	epoxide hydrolase 1	Homo sapiens	0-5
8010982-1	1994	Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.	10,11-epoxide	29-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	8-14
8010982-1	1994	Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.	10,11-epoxide	29-42	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	19-25
8010982-6	1994	These findings indicate that CYP3A4 is the principal catalyst of 10,11-epoxide formation in human liver.	10,11-epoxide	65-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
33217013-12	2021	CONCLUSION: Our data indicate that carbamazepine clearance was affected by total dose and phenytoin co-administration, but not by genetic factors, while carbamazepine 10,11-epoxide clearance was affected by a variant in the microsomal epoxide hydrolase gene.	10,11-epoxide	167-180	epoxide hydrolase 1	Homo sapiens	224-252
33671323-5	2021	The carbamazepine model applies metabolism by CYP3A4 and CYP2C8 to produce carbamazepine-10,11-epoxide, metabolism by CYP2B6 and UDP-glucuronosyltransferase (UGT) 2B7 and glomerular filtration.	10,11-epoxide	89-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	46-52
33671323-5	2021	The carbamazepine model applies metabolism by CYP3A4 and CYP2C8 to produce carbamazepine-10,11-epoxide, metabolism by CYP2B6 and UDP-glucuronosyltransferase (UGT) 2B7 and glomerular filtration.	10,11-epoxide	89-102	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	57-63
33671323-6	2021	The carbamazepine-10,11-epoxide model applies metabolism by epoxide hydroxylase 1 (EPHX1) and glomerular filtration.	10,11-epoxide	18-31	epoxide hydrolase 1	Homo sapiens	60-81
33671323-6	2021	The carbamazepine-10,11-epoxide model applies metabolism by epoxide hydroxylase 1 (EPHX1) and glomerular filtration.	10,11-epoxide	18-31	epoxide hydrolase 1	Homo sapiens	83-88
25545162-3	2015	On the basis of these simulations, we engineered CYP3A4 mutants I369F, I369L, A370V, and A370L, in which the productive binding orientation was expected to be stabilized, thus leading to increased turnover of CBZ to the 10,11-epoxide product.	10,11-epoxide	220-233	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55
24817818-1	2014	BACKGROUND: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the active metabolite of CBZ) by evaluating the variation in serum CBZ 10,11-epoxide levels 4 hours after administration of the drug.	10,11-epoxide	238-251	epoxide hydrolase 1	Homo sapiens	142-147