PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 16904801-6 2006 Data demonstrate a suppressive influence of sodium sulfite and sorbic acid on the activated Th1-type immune response. Sorbic Acid 63-74 negative elongation factor complex member C/D Homo sapiens 92-95 17141908-0 2007 High Pdr12 levels in spoilage yeast (Saccharomyces cerevisiae) correlate directly with sorbic acid levels in the culture medium but are not sufficient to provide cells with acquired resistance to the food preservative. Sorbic Acid 87-98 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 5-10 17141908-3 2007 Here we show that the yeast membrane protein Pdr12, previously shown to be prominently involved in sorbic acid resistance development in laboratory strains, was strongly induced by the presence of sorbic acid in the culture medium in Saccharomyces strains isolated from spoiled foods. Sorbic Acid 99-110 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 45-50 17141908-3 2007 Here we show that the yeast membrane protein Pdr12, previously shown to be prominently involved in sorbic acid resistance development in laboratory strains, was strongly induced by the presence of sorbic acid in the culture medium in Saccharomyces strains isolated from spoiled foods. Sorbic Acid 197-208 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 45-50 11746603-7 2001 Thus, the induction of Hsp26, which occurs during adaptation to sorbic acid, confers resistance to the inhibitory effects of this compound. Sorbic Acid 64-75 chaperone protein HSP26 Saccharomyces cerevisiae S288C 23-28 16544288-0 2006 New tools for phenotypic analysis in Candida albicans: the WAR1 gene confers resistance to sorbate. Sorbic Acid 91-98 War1p Saccharomyces cerevisiae S288C 59-63 15490173-4 2004 We show here that PB and sorbic acid induce an ubiquitin-dependent turnover of the tryptophan permease Tat2p. Sorbic Acid 25-36 aromatic amino acid transmembrane transporter TAT2 Saccharomyces cerevisiae S288C 103-108 11737636-0 2001 The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in Saccharomyces cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives. Sorbic Acid 171-178 Yme2p Saccharomyces cerevisiae S288C 6-10 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 heat shock protein HSP42 Saccharomyces cerevisiae S288C 114-119 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 F1F0 ATP synthase subunit beta Saccharomyces cerevisiae S288C 121-125 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 chaperone protein HSP26 Saccharomyces cerevisiae S288C 127-132 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 134-138 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 Hsp70 family chaperone SSA2 Saccharomyces cerevisiae S288C 142-146 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 Hsp70 family ATPase SSB1 Saccharomyces cerevisiae S288C 148-152 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 Hsp70 family ATPase SSB2 Saccharomyces cerevisiae S288C 156-160 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 Hsp70 family ATPase SSC1 Saccharomyces cerevisiae S288C 162-166 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 Hsp70 family chaperone SSA4 Saccharomyces cerevisiae S288C 168-172 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 acetyl-CoA hydrolase Saccharomyces cerevisiae S288C 174-178 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 glucose-6-phosphate dehydrogenase Saccharomyces cerevisiae S288C 180-184 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 Saccharomyces cerevisiae S288C 189-193 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16 Saccharomyces cerevisiae S288C 237-242 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 alcohol dehydrogenase ADH3 Saccharomyces cerevisiae S288C 244-248 11746603-1 2001 Exposure of Saccharomyces cerevisiae to 0.9 mM sorbic acid at pH 4.5 resulted in the upregulation of 10 proteins; Hsp42, Atp2, Hsp26, Ssa1 or Ssa2, Ssb1 or Ssb2, Ssc1, Ssa4, Ach1, Zwf1 and Tdh1; and the downregulation of three proteins; Ade16, Adh3 and Eno2. Sorbic Acid 47-58 phosphopyruvate hydratase ENO2 Saccharomyces cerevisiae S288C 253-257 11746603-2 2001 In parallel, of 6144 ORFs, 94 (1.53%) showed greater than a 1.4-fold increase in transcript level after exposure to sorbic acid and five of these were increased greater than two-fold; MFA1, AGA2, HSP26, SIP18 and YDR533C. Sorbic Acid 116-127 mating pheromone a Saccharomyces cerevisiae S288C 184-188 11746603-2 2001 In parallel, of 6144 ORFs, 94 (1.53%) showed greater than a 1.4-fold increase in transcript level after exposure to sorbic acid and five of these were increased greater than two-fold; MFA1, AGA2, HSP26, SIP18 and YDR533C. Sorbic Acid 116-127 Aga2p Saccharomyces cerevisiae S288C 190-194 11746603-2 2001 In parallel, of 6144 ORFs, 94 (1.53%) showed greater than a 1.4-fold increase in transcript level after exposure to sorbic acid and five of these were increased greater than two-fold; MFA1, AGA2, HSP26, SIP18 and YDR533C. Sorbic Acid 116-127 chaperone protein HSP26 Saccharomyces cerevisiae S288C 196-201 11746603-2 2001 In parallel, of 6144 ORFs, 94 (1.53%) showed greater than a 1.4-fold increase in transcript level after exposure to sorbic acid and five of these were increased greater than two-fold; MFA1, AGA2, HSP26, SIP18 and YDR533C. Sorbic Acid 116-127 Sip18p Saccharomyces cerevisiae S288C 203-208 11746603-3 2001 Similarly, of 6144 ORFs, 72 (1.17%) showed greater than a 1.4-fold decrease in transcript level and only one of these, PCK1, was decreased greater than two-fold Functional categories of genes that were induced by sorbic acid stress included cell stress (particularly oxidative stress), transposon function, mating response and energy generation. Sorbic Acid 213-224 phosphoenolpyruvate carboxykinase PCK1 Saccharomyces cerevisiae S288C 119-123 11746603-6 2001 Subsequently, we demonstrated that a deletion mutant of Hsp26 was sensitive to sorbic acid. Sorbic Acid 79-90 chaperone protein HSP26 Saccharomyces cerevisiae S288C 56-61 14617816-7 2004 Although induction of the majority of sorbate-induced genes required Msn2p/4p, weak acid tolerance was unaffected by a lack of Msn2p/4p. Sorbic Acid 38-45 stress-responsive transcriptional activator MSN2 Saccharomyces cerevisiae S288C 69-74 14617816-8 2004 Ectopic expression of PDR12 from the GAL1-10 promoter fully restored sorbate resistance in a strain lacking War1p, demonstrating that PDR12 is the major target of War1p under sorbic acid stress. Sorbic Acid 175-186 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 22-27 14617816-8 2004 Ectopic expression of PDR12 from the GAL1-10 promoter fully restored sorbate resistance in a strain lacking War1p, demonstrating that PDR12 is the major target of War1p under sorbic acid stress. Sorbic Acid 175-186 galactokinase Saccharomyces cerevisiae S288C 37-41 14617816-8 2004 Ectopic expression of PDR12 from the GAL1-10 promoter fully restored sorbate resistance in a strain lacking War1p, demonstrating that PDR12 is the major target of War1p under sorbic acid stress. Sorbic Acid 175-186 War1p Saccharomyces cerevisiae S288C 108-113 14617816-8 2004 Ectopic expression of PDR12 from the GAL1-10 promoter fully restored sorbate resistance in a strain lacking War1p, demonstrating that PDR12 is the major target of War1p under sorbic acid stress. Sorbic Acid 175-186 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 134-139 14617816-8 2004 Ectopic expression of PDR12 from the GAL1-10 promoter fully restored sorbate resistance in a strain lacking War1p, demonstrating that PDR12 is the major target of War1p under sorbic acid stress. Sorbic Acid 175-186 War1p Saccharomyces cerevisiae S288C 163-168 12734796-6 2003 Its gene (PDR12) is strongly induced by sorbate, benzoate and certain other moderately lipophilic carboxylate compounds, but not by organic alcohols or high levels of acetate. Sorbic Acid 40-47 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 10-15 11053386-5 2000 Deletion of BTN1, BTN2, or HSP30 does not alter cytosolic pH but diminishes pH buffering capacity and causes poor growth at low pH in a medium containing sorbic acid, a condition known to result in disturbed intracellular pH homeostasis. Sorbic Acid 154-165 CLN3 lysosomal/endosomal transmembrane protein, battenin Homo sapiens 12-16 11053386-5 2000 Deletion of BTN1, BTN2, or HSP30 does not alter cytosolic pH but diminishes pH buffering capacity and causes poor growth at low pH in a medium containing sorbic acid, a condition known to result in disturbed intracellular pH homeostasis. Sorbic Acid 154-165 Btn2p Saccharomyces cerevisiae S288C 18-22 11053386-5 2000 Deletion of BTN1, BTN2, or HSP30 does not alter cytosolic pH but diminishes pH buffering capacity and causes poor growth at low pH in a medium containing sorbic acid, a condition known to result in disturbed intracellular pH homeostasis. Sorbic Acid 154-165 Hsp30p Saccharomyces cerevisiae S288C 27-32 10419965-1 1999 Growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid results in the induction of the ATP-binding cassette (ABC) transporter Pdr12 in the plasma membrane (P. Piper, Y. Mahe, S. Thompson, R. Pandjaitan, C. Holyoak, R. Egner, M. Muhlbauer, P. Coote, and K. Kuchler, EMBO J. Sorbic Acid 81-92 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 164-169 10809730-2 2000 K. lactis cells carrying a disrupted sit4 allele are resistant to oligomycin, antimycin, ketoconazole, and econazole but hypersensitive to paromomycin, sorbic acid, and 4-nitroquinoline-N-oxide (4-NQO). Sorbic Acid 152-163 type 2A-related serine/threonine-protein phosphatase SIT4 Saccharomyces cerevisiae S288C 37-41 10809730-3 2000 Overexpression of SIT4 leads to an elevation in resistance to paromomycin and to lesser extent tolerance to sorbic acid, but it has no detectable effect on resistance to 4-NQO. Sorbic Acid 108-119 type 2A-related serine/threonine-protein phosphatase SIT4 Saccharomyces cerevisiae S288C 18-22 10419965-11 1999 Thus, these data provide strong evidence that sorbate and benzoate anions compete with fluorescein for a putative monocarboxylate binding site on the Pdr12 transporter. Sorbic Acid 46-53 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 150-155 23604654-1 1996 The effect of processing steps as well preservatives used in French bread making namely propionic acid and/or potassium sorbate (0.2%) on the destruction of aflatoxins B1 and G1 was studied.Mixing and baking processes showed marked destruction of aflatoxins B1 and G1; being 71.2% and 52.5% for aflatoxin B1 after mixing and baking steps, while reaching 73.9% and 54.5% for aflatoxin G1. Sorbic Acid 110-127 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 168-177 9687494-1 1998 Exposure of Saccharomyces cerevisiae to sorbic acid strongly induces two plasma membrane proteins, one of which is identified in this study as the ATP-binding cassette (ABC) transporter Pdr12. Sorbic Acid 40-51 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 186-191 9687494-3 1998 However, sorbate treatment causes a dramatic induction of Pdr12 in the plasma membrane. Sorbic Acid 9-16 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 58-63 8795204-4 1996 A pma1-205 mutant, with about half the normal membrane H+-ATPase activity, was shown to be more sensitive to sorbic acid than its parent. Sorbic Acid 109-120 H(+)-exporting P2-type ATPase PMA1 Saccharomyces cerevisiae S288C 2-6 8795204-5 1996 Sorbic acid appeared to stimulate plasma membrane H+-ATPase activity in both PMA1 and pma1-205. Sorbic Acid 0-11 H(+)-exporting P2-type ATPase PMA1 Saccharomyces cerevisiae S288C 77-81 8795204-5 1996 Sorbic acid appeared to stimulate plasma membrane H+-ATPase activity in both PMA1 and pma1-205. Sorbic Acid 0-11 H(+)-exporting P2-type ATPase PMA1 Saccharomyces cerevisiae S288C 86-90 7979442-0 1994 Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. Sorbic Acid 122-133 prostaglandin D2 synthase Homo sapiens 44-60 7979442-3 1994 Recently, we have shown that cutaneous erythema similar to that associated with the application of sorbic acid is induced by topical administration of methylnicotinate and is mediated by the release of prostaglandin D2 (PGD2) from the skin. Sorbic Acid 99-110 prostaglandin D2 synthase Homo sapiens 202-218 34461170-4 2021 Benzalkonium chloride (0.015% w/w), Methocel E50 premium LV (1.0% w/w), propylene glycol (1.5% w/w), potassium sorbate + propylene glycol (0.3% w/w + 1.5% w/w) and polysorbate 80 (0.025% w/w), used at common working concentrations, all increased the secretion of mucin from the explants (P<0.05). Sorbic Acid 102-119 LOC100508689 Homo sapiens 264-269 32795858-1 2021 Sorbic acid and its potassium and calcium salts used as food preservatives and sorbic chloride were submitted to thermal analysis in order to characterize their thermal behavior on heating and cooling processes, using TG/DTG/DTA, TG-MS, DSC, hot stage microscopy and DRX analysis. Sorbic Acid 0-11 desmocollin 3 Homo sapiens 237-240 30866360-5 1982 In general, the 40 ppm of nitrite + 0.26% of potassium sorbate cure provided greater bacterial inhibition (especially in fat bacon) than did the nitrite cure. Sorbic Acid 45-62 FAT atypical cadherin 1 Homo sapiens 121-124 5861281-0 1965 Catalase inhibition as a possible mechanism of the fungistatic action of sorbic acid. Sorbic Acid 73-84 catalase Homo sapiens 0-8 4464080-0 1974 [Study of the interaction of sorbic acid with T-1 and T-2 emulsifiers]. Sorbic Acid 29-40 interleukin 1 receptor like 1 Homo sapiens 46-49 33241373-9 2020 HIGHLIGHTS: The HPLC methods coupled with the PLS-2 and PCR algorithm could provide a simple, quick and accurate strategy for simultaneous determination of sodium benzoate, potassium sorbate, ponceau 4R, and carmoisine in a beverage sample. Sorbic Acid 173-190 lymphocyte cytosolic protein 1 Homo sapiens 46-51 14938321-0 1952 Selectivity of sorbic acid media for the catalase negative lactic acid bacteria and clostridia. Sorbic Acid 15-26 catalase Homo sapiens 41-49 30579637-8 2019 Under optimal experimental conditions the linear detection ranges were found to be 0.1-150 mg L-1 for benzoic acid and 0.05-100 mg L-1 for sorbic acid with LODs calculated from a blank test, based on 3sigma, 0.03 mg L-1 and 0.02 mg L-1, respectively. Sorbic Acid 139-150 immunoglobulin kappa variable 1-16 Homo sapiens 131-134 31751501-6 2019 PRACTICAL APPLICATION: The study indicates that Brazilian red propolis at 0.05% concentration to replace the potassium sorbate is an efficient alternative for use in yogurt production. Sorbic Acid 109-126 PRAC1 small nuclear protein Homo sapiens 0-9 31596293-3 2019 PS exposure triggered immune regulation of zebrafish, significantly reducing the content of diverse biomarkers in the gut, including Immunoglobulin G (IgG), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Sorbic Acid 0-2 interleukin 1, beta Danio rerio 157-174 31596293-3 2019 PS exposure triggered immune regulation of zebrafish, significantly reducing the content of diverse biomarkers in the gut, including Immunoglobulin G (IgG), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Sorbic Acid 0-2 interleukin 1, beta Danio rerio 176-184 31596293-3 2019 PS exposure triggered immune regulation of zebrafish, significantly reducing the content of diverse biomarkers in the gut, including Immunoglobulin G (IgG), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Sorbic Acid 0-2 tumor necrosis factor a (TNF superfamily, member 2) Danio rerio 190-217 31596293-3 2019 PS exposure triggered immune regulation of zebrafish, significantly reducing the content of diverse biomarkers in the gut, including Immunoglobulin G (IgG), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Sorbic Acid 0-2 tumor necrosis factor a (TNF superfamily, member 2) Danio rerio 219-228 31100042-5 2019 This method showed good linearity, and the LOQs were 10 mg/kg for BA, SOA and DHA and 5 mg/kg for the PHBAs. Sorbic Acid 70-73 TARBP2 subunit of RISC loading complex Homo sapiens 43-47 30579637-8 2019 Under optimal experimental conditions the linear detection ranges were found to be 0.1-150 mg L-1 for benzoic acid and 0.05-100 mg L-1 for sorbic acid with LODs calculated from a blank test, based on 3sigma, 0.03 mg L-1 and 0.02 mg L-1, respectively. Sorbic Acid 139-150 immunoglobulin kappa variable 1-16 Homo sapiens 131-134 30579637-8 2019 Under optimal experimental conditions the linear detection ranges were found to be 0.1-150 mg L-1 for benzoic acid and 0.05-100 mg L-1 for sorbic acid with LODs calculated from a blank test, based on 3sigma, 0.03 mg L-1 and 0.02 mg L-1, respectively. Sorbic Acid 139-150 immunoglobulin kappa variable 1-16 Homo sapiens 131-134 30476185-4 2019 Haa1 is most sensitive to acetate, followed by lactate, whereas War1 is most sensitive to benzoate, followed by sorbate, reflecting their differential activation during weak acid stresses. Sorbic Acid 112-119 Haa1p Saccharomyces cerevisiae S288C 0-4 32626251-1 2019 In this opinion, the EFSA Panel on Food Additives and Flavourings (FAF Panel) was requested by the European Commission to carry out a scientific evaluation of an extended one-generation reproductive toxicity study (EOGRTS) to determine whether it would allow reconsideration of the temporary group acceptable daily intake (ADI) for sorbic acid (E 200) and potassium sorbate (E 202), established by the Panel on Food Additives and Nutrient Sources added to Food (ANS Panel) in 2015. Sorbic Acid 332-343 ubiquitin specific peptidase 9 X-linked Homo sapiens 67-70 32626251-2 2019 From the EOGTRS, the FAF Panel identified a lower confidence limit of the benchmark dose (BMDL) of 1,110 mg sorbic acid/kg body weight (bw) per day. Sorbic Acid 108-119 ubiquitin specific peptidase 9 X-linked Homo sapiens 21-24 30476185-4 2019 Haa1 is most sensitive to acetate, followed by lactate, whereas War1 is most sensitive to benzoate, followed by sorbate, reflecting their differential activation during weak acid stresses. Sorbic Acid 112-119 War1p Saccharomyces cerevisiae S288C 64-68 25965485-3 2015 S95 films formed bilayers with PCL with very good adhesion and good mechanical performance, especially when potassium sorbate was added at the interface. Sorbic Acid 108-125 PHD finger protein 1 Homo sapiens 31-34 28535459-9 2017 Based on the high agreement between the calculated and experimental NIR spectra, a detailed NIR band assignments are proposed for hexanoic acid and sorbic acid. Sorbic Acid 148-159 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 68-71 28535459-9 2017 Based on the high agreement between the calculated and experimental NIR spectra, a detailed NIR band assignments are proposed for hexanoic acid and sorbic acid. Sorbic Acid 148-159 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 92-95 27135698-9 2016 Addition of sorbic acid (a (3)NOM* quencher) significantly reduced the photolytic rate of BDE-153 confirming the important role of (3)NOM* in indirect photolysis. Sorbic Acid 12-23 homeobox D13 Homo sapiens 90-93 28229641-0 2016 Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFkappaB, GADD45alpha, and MAPK8 genes. Sorbic Acid 33-50 nuclear factor kappa B subunit 1 Homo sapiens 103-111 28229641-0 2016 Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFkappaB, GADD45alpha, and MAPK8 genes. Sorbic Acid 33-50 growth arrest and DNA damage inducible alpha Homo sapiens 113-124 28229641-0 2016 Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFkappaB, GADD45alpha, and MAPK8 genes. Sorbic Acid 33-50 mitogen-activated protein kinase 8 Homo sapiens 130-135 26964248-5 2015 The PSO-BP neural network can accurately measure the concentration of potassium sorbate in orange juice in the range of 0.1-2.0 g L-1. Sorbic Acid 70-87 L1 cell adhesion molecule Homo sapiens 132-135 25965485-5 2015 Bilayers consisting of PCL and starch containing 5% PCL, with potassium sorbate at the interface, showed the best mechanical and barrier properties and interfacial adhesion while having active properties, associated with the antimicrobial action of potassium sorbate. Sorbic Acid 62-79 PHD finger protein 1 Homo sapiens 23-26 25965485-5 2015 Bilayers consisting of PCL and starch containing 5% PCL, with potassium sorbate at the interface, showed the best mechanical and barrier properties and interfacial adhesion while having active properties, associated with the antimicrobial action of potassium sorbate. Sorbic Acid 62-79 PHD finger protein 1 Homo sapiens 52-55 25965485-5 2015 Bilayers consisting of PCL and starch containing 5% PCL, with potassium sorbate at the interface, showed the best mechanical and barrier properties and interfacial adhesion while having active properties, associated with the antimicrobial action of potassium sorbate. Sorbic Acid 249-266 PHD finger protein 1 Homo sapiens 23-26 25965485-5 2015 Bilayers consisting of PCL and starch containing 5% PCL, with potassium sorbate at the interface, showed the best mechanical and barrier properties and interfacial adhesion while having active properties, associated with the antimicrobial action of potassium sorbate. Sorbic Acid 249-266 PHD finger protein 1 Homo sapiens 52-55 25406487-0 2014 Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517-sorbic acid cocrystal production. Sorbic Acid 90-101 amelogenin X-linked Homo sapiens 82-85 24647746-2 2014 The application of this methodology in the asymmetric synthesis of a range of C(5)-substituted 1,2-anti-1,5-syn-transpentacins was demonstrated by the rearrangement of a range of beta-amino esters derived from sorbic acid, followed by esterification, ring-closing metathesis, hydrogenolytic deprotection/reduction, and hydrolysis, which gave the C(5)-substituted transpentacins in only 9 steps from commercially available starting materials. Sorbic Acid 210-221 synemin Homo sapiens 54-57 24324463-5 2013 In yeast, sorbic acid stress causes activation of many genes via the transcription factors Msn2 and Msn4. Sorbic Acid 10-21 stress-responsive transcriptional activator MSN2 Saccharomyces cerevisiae S288C 91-95 24324463-5 2013 In yeast, sorbic acid stress causes activation of many genes via the transcription factors Msn2 and Msn4. Sorbic Acid 10-21 stress-responsive transcriptional activator MSN4 Saccharomyces cerevisiae S288C 100-104 22919070-6 2012 The resulting FFA2-RASSL displayed a >100-fold loss of activity to endogenous ligands, while responding to the distinct ligand sorbic acid with pEC(50) values for inhibition of cAMP, 5.83 +- 0.11; Ca(2+) mobilization, 4.63 +- 0.05; ERK phosphorylation, 5.61 +- 0.06; and dynamic mass redistribution, 5.35 +- 0.06. Sorbic Acid 130-141 free fatty acid receptor 2 Homo sapiens 14-18 23334094-5 2013 The plasma membrane H+-ATPase proton pump (Pma1p) was strongly inhibited by sorbic acid at the growth-inhibitory concentration, but was stimulated by acetic acid. Sorbic Acid 76-87 H(+)-exporting P2-type ATPase PMA1 Saccharomyces cerevisiae S288C 43-48 23334094-7 2013 Levels of PMA1 transcripts increased briefly following sorbic acid addition, but soon returned to normal levels. Sorbic Acid 55-66 H(+)-exporting P2-type ATPase PMA1 Saccharomyces cerevisiae S288C 10-14 21238741-4 2011 Under optimized conditions, sorbic acid and benzoic acid were well separated within 10 min, and the detection limits were 0.05 muM (5.6 mug L(-1)) and 0.08 muM (9.8 mug L(-1)), respectively. Sorbic Acid 28-39 latexin Homo sapiens 127-130 22113732-7 2012 However, the mrk1 mutant was identified as having an elevated Pdr12 level in the absence of sorbate stress. Sorbic Acid 93-100 putative serine/threonine protein kinase MRK1 Saccharomyces cerevisiae S288C 13-17 21421836-1 2011 Sorbic acid (SA) is a PUFA with a conjugated double bond. Sorbic Acid 0-11 Polyunsaturated fatty acid percentage Sus scrofa 22-26 21421836-1 2011 Sorbic acid (SA) is a PUFA with a conjugated double bond. Sorbic Acid 13-15 Polyunsaturated fatty acid percentage Sus scrofa 22-26 21421836-10 2011 It was noted that the smallest SA treatment dose (0.5 g/kg) dramatically increased (P < 0.05) serum IGF-I concentration but decreased (P < 0.05) the concentrations of blood urea N and cortisol. Sorbic Acid 31-33 insulin like growth factor 1 Sus scrofa 103-108 21238741-4 2011 Under optimized conditions, sorbic acid and benzoic acid were well separated within 10 min, and the detection limits were 0.05 muM (5.6 mug L(-1)) and 0.08 muM (9.8 mug L(-1)), respectively. Sorbic Acid 28-39 latexin Homo sapiens 156-159 17766451-0 2007 Decarboxylation of sorbic acid by spoilage yeasts is associated with the PAD1 gene. Sorbic Acid 19-30 phenylacrylic acid decarboxylase PAD1 Saccharomyces cerevisiae S288C 73-77 18952040-3 2009 After enzymatic reaction of human serum paraoxonase (PON1) with nerve gas, substrate was removed with dichloromethane, and alkyl methylphoshphonates were quantified by capillary electrophoresis of reversed osmotic flow using cationic detergent and sorbic acid. Sorbic Acid 248-259 paraoxonase 1 Homo sapiens 53-57 18240334-5 2008 Other carboxylate preservatives (propionate, sorbate or benzoate) are too large to traverse the Fps1p pore. Sorbic Acid 45-52 Fps1p Saccharomyces cerevisiae S288C 96-101 20726777-1 2010 Exposure of Saccharomyces cerevisiae to weak organic acids such as sorbate, propionate, or benzoate rapidly induces the plasma membrane ABC transporter Pdr12, requiring the Zn(II)(2)Cys(6) zinc-finger transcription factor War1. Sorbic Acid 67-74 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 152-157 20726777-1 2010 Exposure of Saccharomyces cerevisiae to weak organic acids such as sorbate, propionate, or benzoate rapidly induces the plasma membrane ABC transporter Pdr12, requiring the Zn(II)(2)Cys(6) zinc-finger transcription factor War1. Sorbic Acid 67-74 War1p Saccharomyces cerevisiae S288C 222-226 24061826-4 2010 The kinetic uptake data, obtained at different sorbate concentrations, is best interpreted by pseudo second order model and rate constants for adsorption are found to be 8.5 x 10-3, 22.2 x 10-3 and 42.0 x 10-3 g mg-1 min-1 for initial dye concentrations of 10, 20 and 30 mg L-1 respectively. Sorbic Acid 47-54 immunoglobulin kappa variable 1-16 Homo sapiens 274-277 19534119-2 2009 However, prediction methods for Koc such as linear free energy relationships (LFERs) are currently only available for high sorbate concentrations (i.e., near solubility limits), reflecting the lack of a set of consistent experimental data in an environmentally more relevant concentration range (i.e., orders of magnitude lower than solubilities). Sorbic Acid 123-130 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 32-35 19534119-8 2009 The present study offers the first PP-LFER equation for log Koc in soil organic matter at typical environmental sorbate concentrations. Sorbic Acid 112-119 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 60-63 18048916-0 2007 A novel role for the yeast protein kinase Dbf2p in vacuolar H+-ATPase function and sorbic acid stress tolerance. Sorbic Acid 83-94 serine/threonine-protein kinase DBF2 Saccharomyces cerevisiae S288C 42-47 18048916-1 2007 In Saccharomyces cerevisiae, the serine-threonine protein kinase activity of Dbf2p is required for tolerance to the weak organic acid sorbic acid. Sorbic Acid 134-145 serine/threonine-protein kinase DBF2 Saccharomyces cerevisiae S288C 77-82 18048916-3 2007 Loss of V-ATPase activity due to bafilomycin treatment or deletion of either VMA1 or VMA2 resulted in sorbic acid hypersensitivity and impaired vacuolar acidification, phenotypes also observed in both a kinase-inactive dbf2 mutant and cells completely lacking DBF2 (dbf2Delta). Sorbic Acid 102-113 H(+)-transporting V1 sector ATPase subunit A Saccharomyces cerevisiae S288C 77-81 18048916-3 2007 Loss of V-ATPase activity due to bafilomycin treatment or deletion of either VMA1 or VMA2 resulted in sorbic acid hypersensitivity and impaired vacuolar acidification, phenotypes also observed in both a kinase-inactive dbf2 mutant and cells completely lacking DBF2 (dbf2Delta). Sorbic Acid 102-113 H(+)-transporting V1 sector ATPase subunit B Saccharomyces cerevisiae S288C 85-89 18048916-4 2007 Crucially, VMA2 is a multicopy suppressor of both the sorbic acid-sensitive phenotype and the impaired vacuolar-acidification defect of dbf2Delta cells, confirming a functional interaction between Dbf2p and Vma2p. Sorbic Acid 54-65 H(+)-transporting V1 sector ATPase subunit B Saccharomyces cerevisiae S288C 11-15 18048916-5 2007 The yeast V-ATPase is therefore involved in mediating sorbic acid stress tolerance, and we have shown a novel and unexpected role for the cell cycle-regulated protein kinase Dbf2p in promoting V-ATPase function. Sorbic Acid 54-65 serine/threonine-protein kinase DBF2 Saccharomyces cerevisiae S288C 174-179 17766451-11 2007 We concluded that Pad1p-mediated sorbic acid decarboxylation did not constitute a significant mechanism of resistance to weak-acid preservatives by spoilage yeasts, even if the decarboxylation contributed to spoilage through the generation of unpleasant odors. Sorbic Acid 33-44 phenylacrylic acid decarboxylase PAD1 Saccharomyces cerevisiae S288C 18-23