PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
6427217-4	1984	IRBP also binds exogenous cholesterol, alpha-tocopherol, and all-trans retinoic acid, all of which are completely displaced by all trans retinol.	2-octenal	65-70	retinol binding protein 3	Bos taurus	0-4
4039817-1	1985	The effective unwinding angle, phi, for cis-diamminedichloroplatinum(II) (cis-DDP) and trans-DDP was determined by utilizing high resolution gel electrophoresis and supercoiled phi X174 RF DNA as a substrate.	2-octenal	87-92	translocase of inner mitochondrial membrane 8A	Homo sapiens	93-96
30674964-4	2019	We have also found that all-trans retinoic acid (ATRA) treatment increased AGAP2 protein levels in both cell lines whilst curcumin treatment reduced ATRA-mediated AGAP2 increase.	2-octenal	28-33	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Homo sapiens	75-80
198206-4	1977	Inversion at C-1 during hydrolysis of trans,trans-farnesyl diphosphate to trans,trans-farnesol could explain this anomaly.	2-octenal	38-43	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	13-16
30679324-0	2019	All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement-interleukin-1beta loop.	2-octenal	4-9	interleukin 1 beta	Homo sapiens	114-131
30824184-1	2019	Genetic mutations on PML-RARalpha in acute promyelocytic leukemia (APL) are reported to associate with arsenic trioxide (ATO) or all-trans retinoic acid (ATRA) resistance.	2-octenal	133-138	PML nuclear body scaffold	Homo sapiens	21-24
30824184-1	2019	Genetic mutations on PML-RARalpha in acute promyelocytic leukemia (APL) are reported to associate with arsenic trioxide (ATO) or all-trans retinoic acid (ATRA) resistance.	2-octenal	133-138	retinoic acid receptor alpha	Homo sapiens	25-33
30864551-1	2019	BACKGROUND: All-trans retinoic acid (ATRA) potentiates TGF-beta-dependent regulatory T cells (Treg) induction, while it inhibits pro-inflammatory interleukin-17-producing T helper cells (Th17) differentiation.	2-octenal	16-21	transforming growth factor, beta 1	Mus musculus	55-63
6847765-0	1983	Inhibition of ultraviolet-B skin carcinogenesis by all-trans-retinoic acid regimens that inhibit ornithine decarboxylase induction.	2-octenal	55-61	ornithine decarboxylase, structural 1	Mus musculus	97-120
413278-5	1977	L-2 at pH 7 yielded hexanal (31), two geometric isomers of 2,4-decadienal (40), 2-trans-heptenal (12) and 2-trans-octenal (10).	2-octenal	106-121	immunoglobulin kappa variable 3-15	Homo sapiens	0-3
31368475-6	2019	The treatment of macrocyclic-bis(NHC)silver(i) complexes 4a and 4b with one equivalent of PdCl2(MeCN)2 in methylene chloride afforded square-planar trans-macrocyclic-bis(NHC)Pd(ii)X2 complexes 5a and 5b.	2-octenal	148-154	phosducin like 2	Homo sapiens	90-102
30612000-0	2019	Lipid-polymer nanoparticles with CD133 aptamers for targeted delivery of all-trans retinoic acid to osteosarcoma initiating cells.	2-octenal	77-82	prominin 1	Homo sapiens	33-38
30237268-2	2019	Administration of all-trans retinoic acid leads to significant changes in gene expression, among the most induced of which is transglutaminase 2, which is not normally expressed in neutrophil granulocytes.	2-octenal	22-27	transglutaminase 2	Homo sapiens	126-144
30316033-3	2019	Instead, TPA might arise from dietary trans-vaccenic acid (trans-C18:1 n-7, TVA), which is more abundant in foods.	2-octenal	38-43	plasminogen activator, tissue type	Rattus norvegicus	9-12
29792731-2	2018	Apoptosis-related protein 3 (APR3) was recently discovered after treatment with all- trans retinoic acid, a pivotal molecule in RPE cells.	2-octenal	85-90	all-trans retinoic acid induced differentiation factor	Homo sapiens	0-27
29938900-8	2018	CCK secretion induced by representative fatty acids (10-oxo-trans-11-18:1 and 13-oxo-cis-9,cis-15-18:2) was attenuated by a fatty acid receptor G-protein coupled receptor 40 antagonist.	2-octenal	60-65	cholecystokinin	Rattus norvegicus	0-3
29938900-8	2018	CCK secretion induced by representative fatty acids (10-oxo-trans-11-18:1 and 13-oxo-cis-9,cis-15-18:2) was attenuated by a fatty acid receptor G-protein coupled receptor 40 antagonist.	2-octenal	60-65	free fatty acid receptor 1	Rattus norvegicus	144-173
30159139-10	2018	Conclusions: All-trans retinoic acid inhibits BMP2/7-induced osteoclastogenesis, and resorption activity possibly via RANKL-RANK pathway.	2-octenal	17-22	bone morphogenetic protein 2	Mus musculus	46-50
30159139-10	2018	Conclusions: All-trans retinoic acid inhibits BMP2/7-induced osteoclastogenesis, and resorption activity possibly via RANKL-RANK pathway.	2-octenal	17-22	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	118-123
30061204-1	2018	BACKGROUND/AIM: N-(4-hydroxyphenyl)retinamide (4-HPR) is a synthetic retinoid, less toxic than the parent all-trans retinoic acid (RA).	2-octenal	110-115	haptoglobin-related protein	Homo sapiens	49-52
29792731-2	2018	Apoptosis-related protein 3 (APR3) was recently discovered after treatment with all- trans retinoic acid, a pivotal molecule in RPE cells.	2-octenal	85-90	all-trans retinoic acid induced differentiation factor	Homo sapiens	29-33
29398485-7	2018	Rescue experiments indicate that FOXD3-AS1 harbors tumor-suppressive properties by inhibiting the oncogenic roles of PARP1 or CTCF and plays crucial roles in all-trans-retinoic-acid-mediated therapeutic effects on NB.	2-octenal	162-168	forkhead box D3	Homo sapiens	33-38
29111326-2	2018	LncRNA Nuclear Enriched Abundant Transcript 1 (NEAT1) is indispensable during acute promyelocytic leukemia (APL) cell differentiation induced by all-trans retinoic acid (ATRA).	2-octenal	149-154	nuclear paraspeckle assembly transcript 1	Homo sapiens	7-45
29111326-2	2018	LncRNA Nuclear Enriched Abundant Transcript 1 (NEAT1) is indispensable during acute promyelocytic leukemia (APL) cell differentiation induced by all-trans retinoic acid (ATRA).	2-octenal	149-154	nuclear paraspeckle assembly transcript 1	Homo sapiens	47-52
29500243-0	2018	All-Trans Retinoic Acid Enhances Antibody Production by Inducing the Expression of Thymic Stromal Lymphopoietin Protein.	2-octenal	4-9	thymic stromal lymphopoietin	Mus musculus	83-111
29398485-7	2018	Rescue experiments indicate that FOXD3-AS1 harbors tumor-suppressive properties by inhibiting the oncogenic roles of PARP1 or CTCF and plays crucial roles in all-trans-retinoic-acid-mediated therapeutic effects on NB.	2-octenal	162-168	prostaglandin D2 receptor	Homo sapiens	39-42
28817605-0	2017	All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis.	2-octenal	4-9	prominin 1	Homo sapiens	64-69
29433202-3	2018	The binding of native SPI to the flavor compounds decreased in the order trans-2-nonenal>nonanal>trans-2-octenal>trans-2-hexenal>hexanal>1-octen-3-ol.	2-octenal	103-118	chromogranin A	Homo sapiens	22-25
29068287-0	2017	Hepatitis B virus X protein suppresses all-trans retinoic acid-induced apoptosis in human hepatocytes by repressing p14 expression via DNA methylation.	2-octenal	43-48	ribonuclease P/MRP subunit p14	Homo sapiens	116-119
28739877-3	2017	We report that PALLD is highly induced along with all-trans-retinoic acid-induced maturation of myeloid leukemia cells, to promote Ig- or complement-opsonized phagocytosis.	2-octenal	54-60	palladin, cytoskeletal associated protein	Homo sapiens	15-20
28394339-0	2017	NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma.	2-octenal	80-85	polycomb group ring finger 1	Homo sapiens	0-5
28928446-4	2017	Upon treating APL with all-trans retinoic acid and achieving complete remission, the levels of PGD2, NKp30, ILC2s, IL-13 and M-MDSCs are restored.	2-octenal	27-32	prostaglandin D2 synthase	Homo sapiens	95-99
28928446-4	2017	Upon treating APL with all-trans retinoic acid and achieving complete remission, the levels of PGD2, NKp30, ILC2s, IL-13 and M-MDSCs are restored.	2-octenal	27-32	natural cytotoxicity triggering receptor 3	Homo sapiens	101-106
28928446-4	2017	Upon treating APL with all-trans retinoic acid and achieving complete remission, the levels of PGD2, NKp30, ILC2s, IL-13 and M-MDSCs are restored.	2-octenal	27-32	interleukin 13	Homo sapiens	115-120
28053092-0	2017	Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells.	2-octenal	97-103	E1A binding protein p300	Homo sapiens	0-30
28482326-7	2017	The Trans-AM assay for Nrf2-binding to the antioxidant response element (ARE) showed a dose-dependent increase associated with upregulation of several major antioxidant genes and proteins.	2-octenal	4-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
28232094-0	2017	Chromatin reader ZMYND8 is a key target of all trans retinoic acid-mediated inhibition of cancer cell proliferation.	2-octenal	47-52	zinc finger, MYND-type containing 8	Mus musculus	17-23
28211306-0	2017	Ex vivo all-trans retinoic acid modulates NO production and regulates IL-6 effect during rheumatoid arthritis: a study in Algerian patients.	2-octenal	12-17	interleukin 6	Homo sapiens	70-74
28053092-0	2017	Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells.	2-octenal	97-103	lysine acetyltransferase 2B	Homo sapiens	71-75
27602766-1	2016	The expression of the retinoic acid-induced G (Rig-G) gene, an all trans retinoic acid (ATRA)-inducible gene, was observed in multiple cancer cells, including lung cancer cells.	2-octenal	67-72	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	47-52
28090317-5	2016	Intriguingly, 10 nM all-trans retinoic acid (ATRA) augmented CD38 expression in KG1, U937 and HL60 cells and primary leukemic cells from AML patients.	2-octenal	24-29	CD38 molecule	Homo sapiens	61-65
28052022-6	2017	By contrast, TbetaRII blocked all-trans retinoic acid-induced differentiation through inhibition of TbetaRII-B.	2-octenal	34-39	transforming growth factor beta receptor 2	Homo sapiens	13-21
28052022-6	2017	By contrast, TbetaRII blocked all-trans retinoic acid-induced differentiation through inhibition of TbetaRII-B.	2-octenal	34-39	transforming growth factor beta receptor 2	Homo sapiens	100-108
27989102-9	2016	Furthermore, silencing of either TIG1 or TMEM192 led to alleviation of the upregulation of autophagy induced by all-trans retinoic acid.	2-octenal	116-121	retinoic acid receptor responder 1	Homo sapiens	33-37
27989102-9	2016	Furthermore, silencing of either TIG1 or TMEM192 led to alleviation of the upregulation of autophagy induced by all-trans retinoic acid.	2-octenal	116-121	transmembrane protein 192	Homo sapiens	41-48
27759097-4	2016	Here we report the first crystal structure of human ALDH1A3 complexed with NAD+ and the product all-trans retinoic acid (REA).	2-octenal	100-105	aldehyde dehydrogenase 1 family member A3	Homo sapiens	52-59
27486764-6	2016	We also show that let-7 microRNA family members promote differentiation of All-Trans-Retinoic Acid (ATRA)-induced NB4 cells and their activities are affected by expression levels of both c-Myc and PML/RARalpha through altering miRNA targets.	2-octenal	79-85	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	187-192
27486764-6	2016	We also show that let-7 microRNA family members promote differentiation of All-Trans-Retinoic Acid (ATRA)-induced NB4 cells and their activities are affected by expression levels of both c-Myc and PML/RARalpha through altering miRNA targets.	2-octenal	79-85	PML nuclear body scaffold	Homo sapiens	197-200
27486764-6	2016	We also show that let-7 microRNA family members promote differentiation of All-Trans-Retinoic Acid (ATRA)-induced NB4 cells and their activities are affected by expression levels of both c-Myc and PML/RARalpha through altering miRNA targets.	2-octenal	79-85	retinoic acid receptor alpha	Homo sapiens	201-209
27367907-3	2016	N-(4-Hydroxyphenyl) retinamide (4-HPR, fenretinide), a synthetic analogue of all-trans retinoic acid, has emerged as a promising and well-tolerated cancer chemopreventive and chemotherapeutic agent for various neoplasms, from breast cancer to neuroblastoma.	2-octenal	81-86	haptoglobin-related protein	Homo sapiens	34-37
27177208-0	2016	A novel all-trans retinoic acid derivative 4-amino-2-trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP.	2-octenal	12-17	tumor protein p53	Homo sapiens	228-231
27177208-0	2016	A novel all-trans retinoic acid derivative 4-amino-2-trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP.	2-octenal	12-17	protein phosphatase 1 regulatory subunit 13B	Homo sapiens	236-241
27177208-0	2016	A novel all-trans retinoic acid derivative 4-amino-2-trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP.	2-octenal	12-17	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	264-269
27050967-0	2016	All-trans retinoic acid prevents the development of type 1 diabetes by affecting the levels of interferon gamma and interleukin 4 in streptozotocin-induced murine diabetes model.	2-octenal	4-9	interferon gamma	Mus musculus	95-111
27146823-1	2016	BACKGROUND: Long noncoding RNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been characterized as a critical factor in all-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia (APL) cells.	2-octenal	132-137	HOXA transcript antisense RNA, myeloid-specific 1	Homo sapiens	71-79
26934949-3	2016	Apoptosis related protein 3 (Apr3) was originally cloned from HL-60 cells induced by all-trans retinoic acid (ATRA).	2-octenal	89-94	all-trans retinoic acid induced differentiation factor	Homo sapiens	0-27
26934949-3	2016	Apoptosis related protein 3 (Apr3) was originally cloned from HL-60 cells induced by all-trans retinoic acid (ATRA).	2-octenal	89-94	all-trans retinoic acid induced differentiation factor	Homo sapiens	29-33
26951332-4	2016	We show that treatment with all-trans retinoic acid (ATRA) at clinically achievable doses markedly enhanced terminal granulocytic differentiation in AML cell lines, primary patient samples, and a xenograft mouse model carrying mutant IDH1.	2-octenal	32-37	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	234-238
27050967-0	2016	All-trans retinoic acid prevents the development of type 1 diabetes by affecting the levels of interferon gamma and interleukin 4 in streptozotocin-induced murine diabetes model.	2-octenal	4-9	interleukin 4	Mus musculus	116-129
27081671-8	2016	Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands.	2-octenal	88-93	steroidogenic acute regulatory protein	Mus musculus	18-22
26531761-6	2016	Synthetic agonists of the VDR and RARgamma as well as the natural agonist all-trans retinoic acid (ATRA) increased TSLP expression in the skin, while an RXR agonist was not active.	2-octenal	78-83	thymic stromal lymphopoietin	Mus musculus	115-119
27081671-8	2016	Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands.	2-octenal	88-93	retinoic acid receptor, alpha	Mus musculus	192-214
27081671-8	2016	Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands.	2-octenal	88-93	retinoic acid receptor, alpha	Mus musculus	216-219
26843326-10	2016	Short-term treatment of mice with all-trans retinoic acid resulted in increased PreB lymphopoiesis in BM and an increase in thymic double-negative 4 T cells, inverse to that observed upon Nes cell-specific deletion of Rargamma.	2-octenal	38-43	prolactin regulatory element binding	Mus musculus	80-84
26843326-10	2016	Short-term treatment of mice with all-trans retinoic acid resulted in increased PreB lymphopoiesis in BM and an increase in thymic double-negative 4 T cells, inverse to that observed upon Nes cell-specific deletion of Rargamma.	2-octenal	38-43	nestin	Mus musculus	188-191
26843326-10	2016	Short-term treatment of mice with all-trans retinoic acid resulted in increased PreB lymphopoiesis in BM and an increase in thymic double-negative 4 T cells, inverse to that observed upon Nes cell-specific deletion of Rargamma.	2-octenal	38-43	retinoic acid receptor, gamma	Mus musculus	218-226
26397460-8	2015	Knockdown of OTX2 expression by siRNA or pharmacologic inhibition by all-trans retinoic acid (ATRA) repressed OTX2 expression and cell proliferation and significantly decreased tumor growth in vivo.	2-octenal	73-78	orthodenticle homeobox 2	Homo sapiens	110-114
25510432-4	2015	In contrast to other NUP98 fusions, cells transformed by the NUP98-RARG fusion were extremely sensitive to all-trans retinoic acid (ATRA) treatment.	2-octenal	42-47	nucleoporin 98	Mus musculus	61-66
26464515-9	2015	Furthermore, differentiation of the neuroblastoma cell line SH-SY5Y induced by all-trans retinoic acid (ATRA) increased both TXNRD1_v1 and TXNRD1_v2 expressions along with several of the identified genes associated with differentiation and adhesion.	2-octenal	83-88	thioredoxin reductase 1	Homo sapiens	125-131
26464515-9	2015	Furthermore, differentiation of the neuroblastoma cell line SH-SY5Y induced by all-trans retinoic acid (ATRA) increased both TXNRD1_v1 and TXNRD1_v2 expressions along with several of the identified genes associated with differentiation and adhesion.	2-octenal	83-88	thioredoxin reductase 1	Homo sapiens	139-145
26059631-6	2015	Finally, miR-125b-2 overexpression was found to impair all-trans-retinoic acid-induced neuron development in embryoid bodies.	2-octenal	59-65	microRNA 125b-2	Mus musculus	9-19
25864619-0	2015	Protection of acute GVHD by all-trans retinoic acid through suppression of T cell expansion and induction of regulatory T cells through IL-2 signaling.	2-octenal	32-37	interleukin 2	Homo sapiens	136-140
26349992-0	2015	Low-dose all-trans retinoic acid enhances cytotoxicity of cisplatin and 5-fluorouracil on CD44(+) cancer stem cells.	2-octenal	12-18	CD44 molecule (Indian blood group)	Homo sapiens	90-94
24992177-2	2015	It is now becoming apparent that signaling through vitamin A metabolites, such as all-trans retinoic acid (ATRA), is indispensable for spermatogenesis and disruption of retinoic acid receptor-alpha (RARalpha) function may result in male sterility and aberrant spermatogenesis.	2-octenal	86-91	retinoic acid receptor alpha	Homo sapiens	199-207
25510432-4	2015	In contrast to other NUP98 fusions, cells transformed by the NUP98-RARG fusion were extremely sensitive to all-trans retinoic acid (ATRA) treatment.	2-octenal	42-47	retinoic acid receptor, gamma	Mus musculus	67-71
25849135-0	2015	Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.	2-octenal	35-40	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	7-11
25451924-6	2015	Indeed, ectopic expression of miR-638 promoted phorbol 12-myristate 13-acetate- or all-trans-retinoic acid-induced differentiation of leukemic cell lines and primary AML blasts, whereas miR-638 inhibition caused an opposite phenotype.	2-octenal	87-93	microRNA 638	Homo sapiens	30-37
25627686-0	2015	Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.	2-octenal	59-65	insulin	Homo sapiens	0-7
25627686-0	2015	Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.	2-octenal	59-65	forkhead box O1	Homo sapiens	100-105
25973309-2	2015	As a fusion protein of promyelocytic leukemia (PML) and retinoic acid receptor-alpha (RARalpha), PML-RARalpha oncoprotein is degraded through the differentiation of all-trans retinoic acid (ATRA)-induced cells.	2-octenal	169-174	PML nuclear body scaffold	Homo sapiens	47-50
25973309-2	2015	As a fusion protein of promyelocytic leukemia (PML) and retinoic acid receptor-alpha (RARalpha), PML-RARalpha oncoprotein is degraded through the differentiation of all-trans retinoic acid (ATRA)-induced cells.	2-octenal	169-174	retinoic acid receptor alpha	Homo sapiens	56-84
25973309-2	2015	As a fusion protein of promyelocytic leukemia (PML) and retinoic acid receptor-alpha (RARalpha), PML-RARalpha oncoprotein is degraded through the differentiation of all-trans retinoic acid (ATRA)-induced cells.	2-octenal	169-174	retinoic acid receptor alpha	Homo sapiens	86-94
25973309-2	2015	As a fusion protein of promyelocytic leukemia (PML) and retinoic acid receptor-alpha (RARalpha), PML-RARalpha oncoprotein is degraded through the differentiation of all-trans retinoic acid (ATRA)-induced cells.	2-octenal	169-174	PML nuclear body scaffold	Homo sapiens	97-100
25973309-2	2015	As a fusion protein of promyelocytic leukemia (PML) and retinoic acid receptor-alpha (RARalpha), PML-RARalpha oncoprotein is degraded through the differentiation of all-trans retinoic acid (ATRA)-induced cells.	2-octenal	169-174	retinoic acid receptor alpha	Homo sapiens	101-109
25161098-0	2014	SPLUNC1 is associated with nasopharyngeal carcinoma prognosis and plays an important role in all-trans-retinoic acid-induced growth inhibition and differentiation in nasopharyngeal cancer cells.	2-octenal	97-103	BPI fold containing family A member 1	Homo sapiens	0-7
25064461-0	2014	Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[(18)F]Mefway.	2-octenal	84-91	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-73
25292047-0	2014	A novel all-trans retinoid acid derivative N-(3-trifluoromethyl- phenyl)- retinamide inhibits lung adenocarcinoma A549 cell migration through down-regulating expression of myosin light chain kinase.	2-octenal	12-17	myosin light chain kinase	Homo sapiens	172-197
24908182-5	2014	The current study investigated the role of CX3CL1 in the chemoattraction of all-trans retinoic acid (ATRA)-treated NB4 (ATRA-NB4) cells toward apoptotic cells.	2-octenal	80-85	C-X3-C motif chemokine ligand 1	Homo sapiens	43-49
24265455-3	2014	In this study we demonstrate that all-trans retinoic acid (atRA) enhances StAR expression, but not its phosphorylation (P-StAR), and progesterone production in MA-10 mouse Leydig cells.	2-octenal	38-43	steroidogenic acute regulatory protein	Mus musculus	74-78
24798977-0	2014	LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines.	2-octenal	61-66	lysyl oxidase	Homo sapiens	0-3
24987934-0	2014	Theoretical study of the gas-phase reactions of NO3 radical with a series of trans-2-unsaturated aldehydes: from acrolein to trans-2-octenal.	2-octenal	125-140	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
24566867-3	2014	In acute promyelocytic leukemia (APL), repression by the PML-RARalpha oncofusion protein is mediated by an HDAC-containing complex that can be dissociated by pharmacologic doses of all trans retinoic acid (ATRA) inducing differentiation and cell death at the expense of side effects and recurrence.	2-octenal	185-190	PML nuclear body scaffold	Homo sapiens	57-60
24566867-3	2014	In acute promyelocytic leukemia (APL), repression by the PML-RARalpha oncofusion protein is mediated by an HDAC-containing complex that can be dissociated by pharmacologic doses of all trans retinoic acid (ATRA) inducing differentiation and cell death at the expense of side effects and recurrence.	2-octenal	185-190	retinoic acid receptor alpha	Homo sapiens	61-69
24566867-3	2014	In acute promyelocytic leukemia (APL), repression by the PML-RARalpha oncofusion protein is mediated by an HDAC-containing complex that can be dissociated by pharmacologic doses of all trans retinoic acid (ATRA) inducing differentiation and cell death at the expense of side effects and recurrence.	2-octenal	185-190	histone deacetylase 9	Homo sapiens	107-111
24655379-8	2014	When differentiation was induced by all-trans retinoic acid, CEACAM6 expression strongly correlated with luminal-like differentiation.	2-octenal	40-45	CEA cell adhesion molecule 6	Homo sapiens	61-68
24051074-2	2013	Among eight stereoisomers synthesized, [trans-(1"R,2"R),6S] isomer 6 exhibited the best BACE1 inhibitory activity, which was statistically superior to that of the corresponding ethylene linker compound (R)-3.	2-octenal	40-45	beta-secretase 1	Homo sapiens	88-93
25030439-0	2014	Effect of 9-cis retinoic acid and all-trans retinoic acid in combination with verapamil on P-glycoprotein expression in L1210 cells.	2-octenal	38-43	phosphoglycolate phosphatase	Mus musculus	91-105
24824789-2	2014	Knockdown of HOTAIRM1 in the NB4 acute promyelocytic leukemia cell line retarded all-trans retinoid acid (ATRA)-induced granulocytic differentiation, resulting in a significantly larger population of immature and proliferating cells that maintained cell cycle progression from G1 to S phases.	2-octenal	85-90	HOXA transcript antisense RNA, myeloid-specific 1	Homo sapiens	13-21
23440512-2	2013	The pleiotropic effects of vitamin A are exerted mainly by one active metabolite, all-trans retinoic acid (atRA), which regulates the expression of a battery of target genes through several families of nuclear receptors (RARs, RXRs, and PPARbeta/delta), polymorphic retinoic acid (RA) response elements, and multiple coregulators.	2-octenal	86-91	peroxisome proliferator activated receptor delta	Homo sapiens	237-245
24099613-3	2013	Therefore, the purpose of our study was to examine the effect of vitamin A metabolite all-trans retinoic acid (ATRA) on Th1-Th2 differentiation in CD4+ T cells under GATA-3 deficiency, which can induce Th1-polarizing condition.	2-octenal	90-95	negative elongation factor complex member C/D	Homo sapiens	120-123
24099613-3	2013	Therefore, the purpose of our study was to examine the effect of vitamin A metabolite all-trans retinoic acid (ATRA) on Th1-Th2 differentiation in CD4+ T cells under GATA-3 deficiency, which can induce Th1-polarizing condition.	2-octenal	90-95	GATA binding protein 3	Homo sapiens	166-172
24099613-3	2013	Therefore, the purpose of our study was to examine the effect of vitamin A metabolite all-trans retinoic acid (ATRA) on Th1-Th2 differentiation in CD4+ T cells under GATA-3 deficiency, which can induce Th1-polarizing condition.	2-octenal	90-95	negative elongation factor complex member C/D	Homo sapiens	202-205
23271512-0	2013	All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene.	2-octenal	4-9	signal transducer and activator of transcription 5B	Homo sapiens	105-111
23271512-0	2013	All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene.	2-octenal	4-9	retinoic acid receptor alpha	Homo sapiens	112-116
22676378-2	2012	In the present study, we aim to test the effect of all trans retinoic acid (ATRA) on ABCA1 expression in human CD4+ T cells and the involvement of cholesterol in ATRA mediated anti-HIV effect.	2-octenal	55-60	ATP binding cassette subfamily A member 1	Homo sapiens	85-90
22982089-0	2013	Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.	2-octenal	98-103	cellular retinoic acid binding protein 1	Homo sapiens	0-40
22982089-0	2013	Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.	2-octenal	98-103	mitogen-activated protein kinase 3	Homo sapiens	84-90
22378018-0	2012	Annexin A1 mediates the anti-inflammatory effects during the granulocytic differentiation process in all-trans retinoic acid-treated acute promyelocytic leukemic cells.	2-octenal	105-110	annexin A1	Homo sapiens	0-10
23207146-9	2013	PDX-1/Hes-1 interactions on cell proliferation were determined by exposure to All-trans Retinoic Acid (At-RA), an inductor of Hes-1.	2-octenal	82-87	pancreatic and duodenal homeobox 1	Mus musculus	0-5
23207146-9	2013	PDX-1/Hes-1 interactions on cell proliferation were determined by exposure to All-trans Retinoic Acid (At-RA), an inductor of Hes-1.	2-octenal	82-87	hes family bHLH transcription factor 1	Mus musculus	6-11
23063977-1	2012	The present study tested whether all-trans retinoic acid (ATRA) and 5-Aza-2"-deoxycitidine (5-Aza) affect AML cell differentiation and growth in vitro by acting on the CCAAT/enhancer binding protein alpha (C/EBPalpha) and c-Myc axis.	2-octenal	37-42	CCAAT enhancer binding protein alpha	Homo sapiens	168-204
23004348-0	2012	An experimental study of the gas-phase reactions of NO3 radicals with a series of unsaturated aldehydes: trans-2-hexenal, trans-2-heptenal, and trans-2-octenal.	2-octenal	144-159	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
22614235-10	2012	Differentiation induction with all-trans retinoic acid induced the upregulation of Reelin and DAB1.	2-octenal	35-40	reelin	Homo sapiens	83-89
22614235-10	2012	Differentiation induction with all-trans retinoic acid induced the upregulation of Reelin and DAB1.	2-octenal	35-40	DAB adaptor protein 1	Homo sapiens	94-98
22807598-10	2012	CONCLUSION: Excess dietary trans fats, saturated fats and salt, along with insufficient fruits and vegetables, generate a substantial burden of CVD in the United Kingdom.	2-octenal	27-32	chromosome 10 open reading frame 90	Homo sapiens	33-37
22798714-7	2012	These observations suggest that, in contrast to all-cis arachidonic acid, all-trans arachidonic acid has the potential to enhance reactive oxygen species generation via xanthine dehydrogenase/xanthine oxidase interconversion in the liver cytosol in vitro.	2-octenal	78-83	xanthine dehydrogenase	Rattus norvegicus	169-191
22258322-2	2012	Our recent in vitro studies suggest that all-trans retinoic acid induces podocyte differentiation by activating the retinoic acid receptor-alpha (RARalpha)/cAMP/PKA/CREB pathway.	2-octenal	45-50	retinoic acid receptor alpha	Homo sapiens	116-144
22327096-0	2012	Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells.	2-octenal	77-82	thrombomodulin	Homo sapiens	0-14
22180426-11	2012	CONCLUSIONS: Improvement of ex vivo fludarabine sensitivity in chronic lymphocytic leukemia cells is associated with increased hCNT3 activity after all-trans-retinoic acid treatment.	2-octenal	152-158	solute carrier family 28 member 3	Homo sapiens	127-132
22258322-2	2012	Our recent in vitro studies suggest that all-trans retinoic acid induces podocyte differentiation by activating the retinoic acid receptor-alpha (RARalpha)/cAMP/PKA/CREB pathway.	2-octenal	45-50	retinoic acid receptor alpha	Homo sapiens	146-154
22258322-2	2012	Our recent in vitro studies suggest that all-trans retinoic acid induces podocyte differentiation by activating the retinoic acid receptor-alpha (RARalpha)/cAMP/PKA/CREB pathway.	2-octenal	45-50	cAMP responsive element binding protein 1	Homo sapiens	165-169
22648617-5	2012	The aim of this study was to investigate the potential of orally administered lycopene and all-trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response-element (RARE)-reporter mouse system.	2-octenal	95-100	retinoic acid receptor, alpha	Mus musculus	171-174
22848172-3	2012	Here we describe targeting of TrkB-binding peptide-conjugated liposomes (PCL) to the TrkB-expressing mouse macrophage-like cell line RAW264, and to all-trans-retinoic acid-treated neuron-like TrkB+ SH-SY5Y human neuroblastoma cells.	2-octenal	152-158	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	30-34
22228505-3	2012	The standard treatment for APL includes anthracycline-based chemotherapeutic agents plus the RARalpha agonist all-trans retinoic acid (ATRA).	2-octenal	114-119	retinoic acid receptor alpha	Homo sapiens	93-101
21954838-3	2012	METHODS: Previous studies have shown that all trans retinoic acid (ATRA) induces the expression of cytokeratin 18 (CK18), indicating the beginning of differentiation into the epithelial lineage.	2-octenal	46-51	keratin 18	Homo sapiens	99-113
21954838-3	2012	METHODS: Previous studies have shown that all trans retinoic acid (ATRA) induces the expression of cytokeratin 18 (CK18), indicating the beginning of differentiation into the epithelial lineage.	2-octenal	46-51	keratin 18	Homo sapiens	115-119
21987446-6	2011	Here, we treated the seminoma-like cell line TCam-2 with the HDAC-inhibitor Depsipeptide, the global demethylating agent 5-aza-2"-deocycytidine, all-trans retinoic acid and the monaminooxidase inhibitor Tranylcipromine and also used knock down approaches to reduce expression of the pluripotency marker NANOG and/or the inhibitor of primordial germ cell differentiation TFAP2C.	2-octenal	149-154	histone deacetylase 9	Homo sapiens	61-65
21308896-0	2011	Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans delta-6-desaturase mutant fat-3.	2-octenal	0-5	Delta(6)-fatty-acid desaturase fat-3;FA_desaturase domain-containing protein	Caenorhabditis elegans	118-123
21907828-0	2011	All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats.	2-octenal	4-9	apolipoprotein E	Rattus norvegicus	72-88
21325480-0	2011	Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation.	2-octenal	42-47	cyclin dependent kinase inhibitor 2A	Homo sapiens	118-121
21488975-6	2011	In skin equivalent cultures, all-trans retinoic acid (RA), the major bioactive form of vitamin A in skin, significantly increased type I procollagen and reduced collagenase (matrix metalloproteinases-1, MMP-1).	2-octenal	33-38	matrix metallopeptidase 1	Homo sapiens	130-201
21488975-6	2011	In skin equivalent cultures, all-trans retinoic acid (RA), the major bioactive form of vitamin A in skin, significantly increased type I procollagen and reduced collagenase (matrix metalloproteinases-1, MMP-1).	2-octenal	33-38	matrix metallopeptidase 1	Homo sapiens	203-208
21325480-0	2011	Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation.	2-octenal	42-47	H3 histone pseudogene 16	Homo sapiens	126-129
21148082-0	2011	Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens.	2-octenal	104-109	neural cell adhesion molecule 1	Homo sapiens	25-29
21187718-2	2011	A hallmark of all-trans retinoic acid (ATRA) responses in APL is PML-RARalpha degradation which promotes cell differentiation.	2-octenal	18-23	PML nuclear body scaffold	Homo sapiens	65-68
21187718-2	2011	A hallmark of all-trans retinoic acid (ATRA) responses in APL is PML-RARalpha degradation which promotes cell differentiation.	2-octenal	18-23	retinoic acid receptor alpha	Homo sapiens	69-77
21285336-4	2011	Computational-based molecular docking simulations indicated that the trans- but not the cis-amide isomers of the benzoquinone ansamycins could be accommodated by the NQO1 active site, and the ranking order of binding energies correlated with the relative reduction rate using purified human NQO1.	2-octenal	69-74	NAD(P)H quinone dehydrogenase 1	Homo sapiens	166-170
21285336-4	2011	Computational-based molecular docking simulations indicated that the trans- but not the cis-amide isomers of the benzoquinone ansamycins could be accommodated by the NQO1 active site, and the ranking order of binding energies correlated with the relative reduction rate using purified human NQO1.	2-octenal	69-74	NAD(P)H quinone dehydrogenase 1	Homo sapiens	291-295
20699116-10	2010	ALDH3B1-transfected HEK293 cells were significantly protected from the lipid peroxidation-derived aldehydes trans-2-octenal, 4HNE, and hexanal and the oxidants H(2)O(2) and menadione.	2-octenal	108-123	aldehyde dehydrogenase 3 family member B1	Homo sapiens	0-7
20974122-7	2011	Its expression was found to be strongly inhibited by DN-RARalpha, an inhibition relieved by pharmacological doses of all-trans retinoic acid (atRA) in culture and in vivo.	2-octenal	121-126	retinoic acid receptor, alpha	Mus musculus	56-64
22128244-9	2011	The FRMD7 transcripts showed similar tissue distributions and were upregulated following all trans retinoic acid (ATRA)-induced differentiation of NT2 cells.	2-octenal	10-15	FERM domain containing 7	Homo sapiens	4-9
21152046-3	2010	To address the question of the effect of rexinoid antagonists on RAR/RXR function, we solved the crystal structure of the heterodimer formed by the ligand binding domain (LBD) of the RARalpha bound to its natural agonist ligand (all-trans retinoic acid, atRA) and RXRalpha bound to a rexinoid antagonist (LG100754).	2-octenal	233-238	retinoic acid receptor alpha	Homo sapiens	183-191
20574048-4	2010	We found that both all-trans retinoic acid and arsenic trioxide induce autophagy via the mammalian target of rapamycin pathway in APL cells and that autophagic degradation contributes significantly both to the basal turnover as well as the therapy-induced proteolysis of PML/RARA.	2-octenal	23-28	PML nuclear body scaffold	Homo sapiens	271-274
20869773-2	2010	Likewise, it is shown that all-trans retinoic acid (ATRA) can greatly enhance TGF-beta-induced Treg conversion, a phenomenon which has mainly been studied in C57BL/6 mice.	2-octenal	31-36	transforming growth factor, beta 1	Mus musculus	78-86
20574048-4	2010	We found that both all-trans retinoic acid and arsenic trioxide induce autophagy via the mammalian target of rapamycin pathway in APL cells and that autophagic degradation contributes significantly both to the basal turnover as well as the therapy-induced proteolysis of PML/RARA.	2-octenal	23-28	retinoic acid receptor alpha	Homo sapiens	275-279
20032483-0	2010	All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases insulin sensitivity in diabetic mice.	2-octenal	3-9	retinol binding protein 4, plasma	Mus musculus	37-62
20081085-12	2010	However, trans-10, cis-12-18:2, rather than cis-9, trans-11-18:2, was detected in the umbilical cord blood, which indicates that CLA may be transported from the sow to the fetus in an isomer-specific manner.	2-octenal	9-14	selectin P ligand	Homo sapiens	129-132
20117194-3	2010	The present study detected expression of sHsps, Hsp40 and Hsp60 in normal and abnormal development of embryonic forelimbs in all-trans retinoic acid (atRA)-induced phocomelic, oligodactylic and atRA-induced abnormal limb bud development models in mice ex vivo.	2-octenal	129-134	heat shock protein 1 (chaperonin)	Mus musculus	58-63
20117817-3	2010	RARalpha agonistic activity was commonly detected in the surface water samples collected along two rivers at different periods, with maximum all-trans retinoic acid (atRA) equivalents of 47.6 ng-atRA/L and 23.5 ng-atRA/L being observed in Lake Biwa-Yodo River and Ina River, respectively.	2-octenal	145-150	retinoic acid receptor alpha	Homo sapiens	0-8
19743856-3	2009	The concentration of hexanal in the headspace increased from 4 to 23 degrees C, but decreased at 37 degrees C. The activity of hexanal-specific hydroperoxide lyase decreases at 37 degrees C. Moreover, precursors of hexanal may go through alternative pathways to form trans-2-heptenal and trans-2-octenal.	2-octenal	288-303	probable pectate lyase P18	Solanum lycopersicum	158-163
19690170-10	2009	In acute promyelocytic leukemia (APL) cells, C/EBPbeta activity is known to be required for all-trans-retinoic acid-induced cell differentiation and disease remission.	2-octenal	96-102	CCAAT enhancer binding protein beta	Homo sapiens	45-54
18728026-11	2008	CONCLUSIONS: This work provides the first demonstration that HIF-1 alpha, a protein rapidly responsive to all-trans retinoic acid, plays a role in all-trans retinoic acid-induced differentiation of leukemic cells.	2-octenal	110-115	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-72
19729598-10	2009	AR(-/-)/apoE(-/-) mice displayed a greater accumulation of the AR substrate 4-hydroxy trans-2-nonenal (HNE) in the plasma and protein-HNE adducts in arterial lesions than AR(+/+)/apoE(-/-) mice.	2-octenal	86-91	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	0-2
19729598-10	2009	AR(-/-)/apoE(-/-) mice displayed a greater accumulation of the AR substrate 4-hydroxy trans-2-nonenal (HNE) in the plasma and protein-HNE adducts in arterial lesions than AR(+/+)/apoE(-/-) mice.	2-octenal	86-91	apolipoprotein E	Mus musculus	8-12
19729598-10	2009	AR(-/-)/apoE(-/-) mice displayed a greater accumulation of the AR substrate 4-hydroxy trans-2-nonenal (HNE) in the plasma and protein-HNE adducts in arterial lesions than AR(+/+)/apoE(-/-) mice.	2-octenal	86-91	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	63-65
19729598-10	2009	AR(-/-)/apoE(-/-) mice displayed a greater accumulation of the AR substrate 4-hydroxy trans-2-nonenal (HNE) in the plasma and protein-HNE adducts in arterial lesions than AR(+/+)/apoE(-/-) mice.	2-octenal	86-91	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	63-65
19486889-1	2009	The zinc finger transcription factor Kruppel-like factor 4 (KLF4) has been implicated in vascular smooth muscle cell differentiation induced by all-trans retinoic acid (ATRA).	2-octenal	16-21	Kruppel like factor 4	Homo sapiens	37-58
19486889-1	2009	The zinc finger transcription factor Kruppel-like factor 4 (KLF4) has been implicated in vascular smooth muscle cell differentiation induced by all-trans retinoic acid (ATRA).	2-octenal	16-21	Kruppel like factor 4	Homo sapiens	60-64
19723072-1	2009	Acute promyelocytic leukemia KG1 cells with t(11;17) PLZF-RARalpha respond poorly to the differentiation inducer all-trans retinoic acid (RA), and the reason for the RA resistance is the recruitment of histone deacetylase by PLZF-RARalpha.	2-octenal	116-122	retinoic acid receptor alpha	Homo sapiens	58-66
19115248-2	2009	The combined action of tamoxifen/all-trans retinoic acid was advantageous in MCF-7 cells, reducing cell proliferation, Bcl-2 and c-Myc protein levels and increasing E-Cadherin protein levels and Gap junctional Intercellular Communication.	2-octenal	37-42	BCL2 apoptosis regulator	Homo sapiens	119-124
19115248-2	2009	The combined action of tamoxifen/all-trans retinoic acid was advantageous in MCF-7 cells, reducing cell proliferation, Bcl-2 and c-Myc protein levels and increasing E-Cadherin protein levels and Gap junctional Intercellular Communication.	2-octenal	37-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	129-134
19115248-2	2009	The combined action of tamoxifen/all-trans retinoic acid was advantageous in MCF-7 cells, reducing cell proliferation, Bcl-2 and c-Myc protein levels and increasing E-Cadherin protein levels and Gap junctional Intercellular Communication.	2-octenal	37-42	cadherin 1	Homo sapiens	165-175
19041605-2	2008	Most patients are treated with all-trans retinoic acid (ATRA), which targets the RAR-alpha moiety of the PML/RAR-alpha fusion transcript, and anthracycline-based chemotherapy.	2-octenal	35-40	PML nuclear body scaffold	Homo sapiens	105-118
19507250-1	2009	Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells.	2-octenal	47-52	CREB regulated transcription coactivator 1	Mus musculus	157-163
19736933-4	2009	We observe that the trans- ONOO- isomer is formed directly and solely from the excited NO3- ion within the first two picoseconds after excitation.	2-octenal	20-25	NBL1, DAN family BMP antagonist	Homo sapiens	87-90
19298684-3	2009	The increased carnitine palmitoyltransferase (CPT)-I activity and mRNA level as well as the increased n-3:n-6 PUFA ratio in liver suggest that trans-10, cis-12-CLA increased the hepatic beta-oxidation by stimulation of PPARalpha.	2-octenal	143-149	carnitine palmitoyltransferase 1B	Rattus norvegicus	14-52
19298684-3	2009	The increased carnitine palmitoyltransferase (CPT)-I activity and mRNA level as well as the increased n-3:n-6 PUFA ratio in liver suggest that trans-10, cis-12-CLA increased the hepatic beta-oxidation by stimulation of PPARalpha.	2-octenal	143-149	peroxisome proliferator activated receptor alpha	Rattus norvegicus	219-228
19557639-0	2009	Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis.	2-octenal	56-62	H3 histone pseudogene 16	Homo sapiens	45-48
19364826-1	2009	Many biological activities of all-trans-retinoic acid (RA) are mediated by the ligand-activated transcription factors termed retinoic acid receptors (RARs), but this hormone can also activate the nuclear receptor peroxisome proliferation-activated receptor beta/delta (PPARbeta/delta).	2-octenal	34-40	peroxisome proliferator activator receptor delta	Mus musculus	269-277
19432991-0	2009	Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion.	2-octenal	75-80	Braf transforming gene	Mus musculus	22-27
19432991-0	2009	Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion.	2-octenal	75-80	midkine	Mus musculus	28-31
19432991-0	2009	Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion.	2-octenal	75-80	mitogen-activated protein kinase 1	Mus musculus	32-35
19171200-1	2009	All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1).	2-octenal	4-9	retinol dehydrogenase 16	Homo sapiens	91-96
19171200-1	2009	All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1).	2-octenal	4-9	aldehyde dehydrogenase 1 family member A2	Homo sapiens	98-104
19171200-1	2009	All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1).	2-octenal	4-9	lecithin retinol acyltransferase	Homo sapiens	110-114
19171200-1	2009	All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1).	2-octenal	4-9	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	135-140
19171200-1	2009	All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1).	2-octenal	4-9	cytochrome P450 family 2 subfamily S member 1	Homo sapiens	145-151
18840692-3	2008	We have previously shown that all-trans retinoic acid (RA) mediates activity blockade-induced synaptic scaling by activating dendritic GluR1 synthesis and that this process requires RARalpha, a member of the nuclear RA receptor family.	2-octenal	34-39	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	135-140
18840692-3	2008	We have previously shown that all-trans retinoic acid (RA) mediates activity blockade-induced synaptic scaling by activating dendritic GluR1 synthesis and that this process requires RARalpha, a member of the nuclear RA receptor family.	2-octenal	34-39	retinoic acid receptor alpha	Homo sapiens	182-190
18446820-0	2008	Characterization of alterations of Rb2/p130 tumor suppressor in all-trans-retinoic acid resistant SK-OV3 ovarian carcinoma cells.	2-octenal	68-74	RB transcriptional corepressor like 2	Homo sapiens	35-38
18446820-0	2008	Characterization of alterations of Rb2/p130 tumor suppressor in all-trans-retinoic acid resistant SK-OV3 ovarian carcinoma cells.	2-octenal	68-74	RB transcriptional corepressor like 2	Homo sapiens	39-43
18798497-0	2008	[Effects of all-trans retinoic acid on the expression of TGF-beta 1 and COL-I in rat model of peritoneal dialysis].	2-octenal	16-21	transforming growth factor, beta 1	Rattus norvegicus	57-67
18839023-0	2008	Inhibition of all-trans retinoic acid on MDM2 gene expression in astrocytoma cell line SHG-44.	2-octenal	18-23	MDM2 proto-oncogene	Homo sapiens	41-45
18585997-1	2008	We previously identified NEDD9 (RAINB2/HEF1/Cas-L) as a new downstream target of all-trans retinoic acid (atRA) and its receptors in the human neuroblastoma cell line, SH-SY5Y [R.A. Merrill, A.W.-M. See, M.L.	2-octenal	85-90	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	25-30
18585997-1	2008	We previously identified NEDD9 (RAINB2/HEF1/Cas-L) as a new downstream target of all-trans retinoic acid (atRA) and its receptors in the human neuroblastoma cell line, SH-SY5Y [R.A. Merrill, A.W.-M. See, M.L.	2-octenal	85-90	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	39-43
18585997-1	2008	We previously identified NEDD9 (RAINB2/HEF1/Cas-L) as a new downstream target of all-trans retinoic acid (atRA) and its receptors in the human neuroblastoma cell line, SH-SY5Y [R.A. Merrill, A.W.-M. See, M.L.	2-octenal	85-90	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	44-49
17824602-3	2007	The reaction of H3L and trans-[CoIIICl2(py)4]+ afforded the chiral (Delta or Lambda) [CoIII(H3L)]3+ complex.	2-octenal	24-29	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	31-36
18084321-4	2008	We report that nanomolar concentrations of all-trans retinoic acid (ATRA) amplify TNFalpha-induced apoptosis in APL cells expressing a specific repressor of NF-kappaB activation.	2-octenal	47-52	tumor necrosis factor	Homo sapiens	82-90
17993618-1	2008	The retinoic acid receptor (RAR) alpha gene (RARA) encodes 2 major isoforms and mediates positive effects of all-trans retinoic acid (ATRA) on myelomonocytic differentiation.	2-octenal	113-118	retinoic acid receptor alpha	Homo sapiens	28-31
17993618-1	2008	The retinoic acid receptor (RAR) alpha gene (RARA) encodes 2 major isoforms and mediates positive effects of all-trans retinoic acid (ATRA) on myelomonocytic differentiation.	2-octenal	113-118	retinoic acid receptor alpha	Homo sapiens	45-49
18974614-3	2008	In this study, the effects of all-trans retinoic acid (atRA), 9-cis RA, and the RAR agonist TTNPB, on UGT2B7 and UGT2B15 mRNA expression in Caco-2 cells have been examined.	2-octenal	34-39	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	102-108
18974614-3	2008	In this study, the effects of all-trans retinoic acid (atRA), 9-cis RA, and the RAR agonist TTNPB, on UGT2B7 and UGT2B15 mRNA expression in Caco-2 cells have been examined.	2-octenal	34-39	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	113-120
18476539-1	2007	OBJECTIVE: To study the reactivation of retinoic acid receptor beta (RARbeta) expression in myeloid leukemia cells by a combination of all-trans retinoic acid (ATRA) with a DNA demethylating agent, decitabine (DAC), and valproic acid (VPA, a histone deacetylase inhibitor),and their effects on cell differentiation and proliferation.	2-octenal	139-144	retinoic acid receptor beta	Homo sapiens	40-67
18476539-1	2007	OBJECTIVE: To study the reactivation of retinoic acid receptor beta (RARbeta) expression in myeloid leukemia cells by a combination of all-trans retinoic acid (ATRA) with a DNA demethylating agent, decitabine (DAC), and valproic acid (VPA, a histone deacetylase inhibitor),and their effects on cell differentiation and proliferation.	2-octenal	139-144	retinoic acid receptor beta	Homo sapiens	69-76
17909034-0	2007	Insulin receptor substrate-1 is an important mediator of ovarian cancer cell growth suppression by all-trans retinoic acid.	2-octenal	103-108	insulin receptor substrate 1	Homo sapiens	0-28
18026954-0	2008	Overexpression of BP1, a homeobox gene, is associated with resistance to all-trans retinoic acid in acute promyelocytic leukemia cells.	2-octenal	77-82	BP1	Homo sapiens	18-21
18156191-0	2008	All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system.	2-octenal	4-9	renin	Rattus norvegicus	107-112
17369494-4	2007	Treatment of THP-1 cells with catalase was able to synergize with all-trans retinoic acid (ATRA) to enhance macrophage differentiation, demonstrated by changes of cell adherence, cell cycle arrest, nitroblue tetrazolium reduction, and expression of differentiation markers including CD68, CD11b, and matrix metalloproteinase 9 (MMP9).	2-octenal	70-75	GLI family zinc finger 2	Homo sapiens	13-18
17510468-6	2007	Thus, an alternative approach to exogenous retinoid administration could be to increase the intracellular level of all-trans retinoic acid by blocking CYP26-mediated degradation of retinoids.	2-octenal	119-124	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	151-156
17369494-4	2007	Treatment of THP-1 cells with catalase was able to synergize with all-trans retinoic acid (ATRA) to enhance macrophage differentiation, demonstrated by changes of cell adherence, cell cycle arrest, nitroblue tetrazolium reduction, and expression of differentiation markers including CD68, CD11b, and matrix metalloproteinase 9 (MMP9).	2-octenal	70-75	catalase	Homo sapiens	30-38
16938888-6	2006	Morpholino knockdown of Rdh5 phenocopied the apc mutant retinal differentiation defects and was rescued by treatment with exogenous all-trans retinoic acid.	2-octenal	136-141	retinol dehydrogenase 5	Homo sapiens	24-28
17035595-2	2007	We have demonstrated previously that all-trans retinoic acid (atRA) plays an important role in forming functional TJs through a specific retinoic acid receptor (RAR)/retinoid X receptor heterodimer in epithelial cells.	2-octenal	41-46	retinoic acid receptor, alpha	Mus musculus	161-164
17257835-2	2007	These inhibitors contain a trans-S,S-methyl cyclopropane P(3) which bind BACE-1 in a 10s-loop down conformation giving rise to highly potent compounds with favorable molecular weight and moderate to high susceptibility to P-glycoprotein (P-gp) efflux.	2-octenal	27-34	beta-secretase 1	Homo sapiens	73-79
17257835-2	2007	These inhibitors contain a trans-S,S-methyl cyclopropane P(3) which bind BACE-1 in a 10s-loop down conformation giving rise to highly potent compounds with favorable molecular weight and moderate to high susceptibility to P-glycoprotein (P-gp) efflux.	2-octenal	27-34	ATP binding cassette subfamily B member 1	Homo sapiens	222-236
17257835-2	2007	These inhibitors contain a trans-S,S-methyl cyclopropane P(3) which bind BACE-1 in a 10s-loop down conformation giving rise to highly potent compounds with favorable molecular weight and moderate to high susceptibility to P-glycoprotein (P-gp) efflux.	2-octenal	27-34	ATP binding cassette subfamily B member 1	Homo sapiens	238-242
17031849-1	2007	We previously demonstrated that endoplasmic reticulum (ER) stress was triggered in human hepatocarcinoma 7721 cells transfected with antisense cDNA of N-acetylglucosaminyltransferase V (GnT-V-AS/7721) which were more susceptible to apoptosis induced by all-trans retinoic acid (ATRA).	2-octenal	116-121	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	151-184
17134824-12	2007	IL-6 was down-regulated in all three cell lines by all-trans-retinoic acid treatment.	2-octenal	55-61	interleukin 6	Homo sapiens	0-4
16458520-8	2006	Sci.1997, 19, 136] demonstrating the inhibitory activity of the terpene trans,trans-farnesol on rat brain MAO-B.	2-octenal	72-77	monoamine oxidase B	Rattus norvegicus	106-111
16922813-0	2006	JWA is required for the antiproliferative and pro-apoptotic effects of all-trans retinoic acid in Hela cells.	2-octenal	75-80	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	0-3
16936753-0	2006	Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid.	2-octenal	103-108	RB transcriptional corepressor like 2	Homo sapiens	0-3
16936753-0	2006	Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid.	2-octenal	103-108	RB transcriptional corepressor like 2	Homo sapiens	4-8
16684888-6	2006	We show that treatment of NB4 cells with all-trans retinoic acid (ATRA) induces BPI expression at mRNA and at protein level.	2-octenal	45-50	bactericidal permeability increasing protein	Homo sapiens	80-83
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	2-octenal	15-20	annexin A6	Homo sapiens	87-97
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	2-octenal	15-20	annexin A6	Homo sapiens	99-104
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	2-octenal	15-20	annexin A6	Homo sapiens	122-127
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	2-octenal	15-20	annexin A6	Homo sapiens	122-127
16674946-1	2006	Vitamin A (all-trans retinol) and all-trans retinoid acid (ATRA) interacted with human annexin A6 (AnxA6) as evidenced by AnxA6-induced blue shift of retinoid absorption maxima, by AnxA6-Trp fluorescence quenching and by a fluorescence resonance energy transfer from a Trp residue of AnxA6 to retinol.	2-octenal	15-20	annexin A6	Homo sapiens	122-127
16479313-8	2005	In view of the present findings we suggest that TGF-beta2 plays important role in pancreatic morphogenesis and administration of excess all-trans retinoic acid before neurulation inhibit TGF-beta2 expression disrupted pancreatic morphogenesis particularly Langerhans islets.	2-octenal	140-145	transforming growth factor, beta 2	Rattus norvegicus	187-196
16914095-5	2006	The inhibitory action of all-trans retinoic acid toward matrix metalloproteinase-9 was however not associated with the STAT1/IRF-1 pathway involved in interferon-mediated matrix metalloproteinase-9 inhibition indicating that all-trans retinoic acid did not bypass IFN receptor signaling.	2-octenal	29-34	matrix metallopeptidase 9	Homo sapiens	56-82
16352814-3	2006	Here we found that conditional expression of promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA), the protein encoded by the t(15;17) translocation found in acute promyelocytic leukemia (APL), suppressed PU.1 expression, while treatment of APL cell lines and primary cells with all-trans retinoic acid (ATRA) restored PU.1 expression and induced neutrophil differentiation.	2-octenal	145-150	Spi-1 proto-oncogene	Homo sapiens	215-219
16352814-3	2006	Here we found that conditional expression of promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA), the protein encoded by the t(15;17) translocation found in acute promyelocytic leukemia (APL), suppressed PU.1 expression, while treatment of APL cell lines and primary cells with all-trans retinoic acid (ATRA) restored PU.1 expression and induced neutrophil differentiation.	2-octenal	145-150	Spi-1 proto-oncogene	Homo sapiens	329-333
16274701-4	2006	Similarly, the increase of Akt activation, as well as PTEN inactivation, was accompanied both by a decrease of CKIepsilon expression induced by all-trans retinoic acid and by the addition of a specific inhibitor for CKIepsilon in HL-60 cells.	2-octenal	148-153	AKT serine/threonine kinase 1	Homo sapiens	27-30
16274701-4	2006	Similarly, the increase of Akt activation, as well as PTEN inactivation, was accompanied both by a decrease of CKIepsilon expression induced by all-trans retinoic acid and by the addition of a specific inhibitor for CKIepsilon in HL-60 cells.	2-octenal	148-153	phosphatase and tensin homolog	Homo sapiens	54-58
16274701-4	2006	Similarly, the increase of Akt activation, as well as PTEN inactivation, was accompanied both by a decrease of CKIepsilon expression induced by all-trans retinoic acid and by the addition of a specific inhibitor for CKIepsilon in HL-60 cells.	2-octenal	148-153	TPTEP2-CSNK1E readthrough	Homo sapiens	111-121
16274701-4	2006	Similarly, the increase of Akt activation, as well as PTEN inactivation, was accompanied both by a decrease of CKIepsilon expression induced by all-trans retinoic acid and by the addition of a specific inhibitor for CKIepsilon in HL-60 cells.	2-octenal	148-153	TPTEP2-CSNK1E readthrough	Homo sapiens	216-226
16517207-6	2006	We found that all-trans retinoic acid-induced apoptosis was associated with concomitant increase in cyclin A1 expression.	2-octenal	18-23	cyclin A1	Homo sapiens	100-109
16517207-10	2006	Further, U-937 cells overexpressing cyclin A1 appeared to be more sensitive to all-trans retinoic acid-induced apoptosis indicating the ability of cyclin A1 to mediate all-trans retinoic acid-induced apoptosis.	2-octenal	83-88	cyclin A1	Homo sapiens	36-45
16517207-12	2006	Our results indicate that cyclin A1 might have a role in apoptosis by mediating all-trans retinoic acid-induced apoptosis.	2-octenal	84-89	cyclin A1	Homo sapiens	26-35
15596294-0	2005	Expression profiles of Id1 and p16 proteins in all-trans-retinoic acid-induced apoptosis and cell cycle re-distribution in melanoma.	2-octenal	51-56	inhibitor of DNA binding 1, HLH protein	Homo sapiens	23-26
15867224-6	2005	Also, shcB was hardly expressed in neuroblastoma cell lines, but its expression in RT-BM-1 cells was enhanced after all-trans-retinoic acid-induced differentiation, and it was highly expressed in low-stage tumors (P = 0.0095).	2-octenal	120-126	SHC adaptor protein 2	Homo sapiens	6-10
15596294-0	2005	Expression profiles of Id1 and p16 proteins in all-trans-retinoic acid-induced apoptosis and cell cycle re-distribution in melanoma.	2-octenal	51-56	cyclin dependent kinase inhibitor 2A	Homo sapiens	31-34
15382060-9	2004	In an RTBM1 neuroblastoma cell line, hTTL was increased after treating the cells with bone morphogenetic protein 2 (BMP2) or all-trans retinoic acid (RA), which induced neuronal differentiation.	2-octenal	129-134	tubulin tyrosine ligase	Homo sapiens	37-41
15510290-4	2004	A similar reaction of fac(S)-[Co(aet)(3)] with [PtCl(4)](2-) or trans-[PtCl(2)(NH(3))(2)] produced an analogous Co(III)Pt(II)Co(III) trinuclear complex, [Pt[Co(aet)(3)](2)](2+)([2](2+)), but both the syn and anti forms were formed for [2](2+).	2-octenal	64-69	synemin	Homo sapiens	200-203
15522764-10	2004	Reports of detrimental effects of CLA intake appear to be largely in mice and due mainly to the trans-10, cis-12 isomer.	2-octenal	96-101	clasper	Mus musculus	34-37
15609095-9	2004	The expression of TGF-beta2 in fetuses whose mothers had been given all-trans retinoic acid after the neurulation period (on day 12 of gestation) was generally similar to that in a control group.	2-octenal	72-77	transforming growth factor, beta 2	Rattus norvegicus	18-27
15369700-3	2004	We demonstrated that nanomolar EGF further enhances transglutaminase activity previously induced by all-trans retinoic acid.	2-octenal	52-57	epidermal growth factor	Homo sapiens	31-34
15326479-5	2004	Conversely, in these cells, TRAIL-induced cell death is magnified by all-trans retinoic acid (ATRA) treatment, independently of telomerase activity on telomeres.	2-octenal	73-78	TNF superfamily member 10	Homo sapiens	28-33
15254726-0	2004	Expression profiles of p53, p21, bax and bcl-2 proteins in all-trans-retinoic acid treated primary and metastatic melanoma cells.	2-octenal	63-69	BCL2 apoptosis regulator	Homo sapiens	41-46
15383262-5	2004	The expression of Bcl-2 was higher in the Bugu Mixture group than that in the all-trans retinoic acid (ATRA) induced group, and the expression of Bax was lower in the Bugu Mixture group than that in the ATRA induced group.	2-octenal	82-87	BCL2, apoptosis regulator	Rattus norvegicus	18-23
15109540-0	2004	Combination of all-trans retinoic acid and lithium chloride surmounts a retinoid differentiation block induced by expression of Scl and Rbtn2 transcription factors in myeloid leukemia cells.	2-octenal	19-24	LIM domain only 2	Homo sapiens	136-141
15246741-6	2004	Furthermore, addition of all-trans retinoic acid (RA) to cultures of RAR alpha-transfected COS-1 cells diminishes RAR alpha and returns levels of MMP-1 to those approaching baseline.	2-octenal	29-34	retinoic acid receptor alpha	Homo sapiens	69-78
15246741-6	2004	Furthermore, addition of all-trans retinoic acid (RA) to cultures of RAR alpha-transfected COS-1 cells diminishes RAR alpha and returns levels of MMP-1 to those approaching baseline.	2-octenal	29-34	retinoic acid receptor alpha	Homo sapiens	114-123
15246741-6	2004	Furthermore, addition of all-trans retinoic acid (RA) to cultures of RAR alpha-transfected COS-1 cells diminishes RAR alpha and returns levels of MMP-1 to those approaching baseline.	2-octenal	29-34	matrix metallopeptidase 1	Homo sapiens	146-151
14729653-2	2004	We recently demonstrated that all-trans retinoic acid (tRA) induces both NIS gene expression and iodide accumulation in vitro in well-differentiated human breast cancer cells (MCF-7).	2-octenal	34-39	solute carrier family 5 member 5	Homo sapiens	73-76
14579009-3	2004	Except for phytoestrogens, most of the tested chemicals (DDT and its metabolites, aldrin, alpha- and beta-endosulfan, toxaphen, trans-nonachlor) show higher affinities for hPR than for hERalpha, indicating that the interaction with the progesterone receptor could contribute to the endocrine-disrupting effects imputed to these chemicals.	2-octenal	128-133	haptoglobin-related protein	Homo sapiens	172-175
14966734-2	2004	The authors investigated whether all-trans retinoic acid (ATRA) affects the expression pattern of Sonic hedgehog (Shh) and Bone morphogenetic protein 4 (BMP4), which play important roles in anorectal morphogenesis in vertebrates.	2-octenal	37-42	sonic hedgehog	Mus musculus	98-112
14966734-2	2004	The authors investigated whether all-trans retinoic acid (ATRA) affects the expression pattern of Sonic hedgehog (Shh) and Bone morphogenetic protein 4 (BMP4), which play important roles in anorectal morphogenesis in vertebrates.	2-octenal	37-42	sonic hedgehog	Mus musculus	114-117
14966734-2	2004	The authors investigated whether all-trans retinoic acid (ATRA) affects the expression pattern of Sonic hedgehog (Shh) and Bone morphogenetic protein 4 (BMP4), which play important roles in anorectal morphogenesis in vertebrates.	2-octenal	37-42	bone morphogenetic protein 4	Mus musculus	153-157
12644474-4	2003	We observed growth arrest and apoptosis, upon decreasing Bcl-2 protein and transcript in the high Bcl-2-expressing, androgen-independent prostate cancer cell line, by all-trans-retinoic acid treatment (ATRA), but this did not occur in the androgen-dependent cell line expressing low levels of Bcl-2.	2-octenal	171-177	BCL2 apoptosis regulator	Homo sapiens	57-62
12958591-3	2003	Using nondenaturing mass spectrometry and scintillation proximity assays we found that all-trans retinoic acid (ATRA) and several retinoids bind to the ROR beta ligand-binding domain (LBD).	2-octenal	91-96	RAR related orphan receptor B	Homo sapiens	152-160
12644474-4	2003	We observed growth arrest and apoptosis, upon decreasing Bcl-2 protein and transcript in the high Bcl-2-expressing, androgen-independent prostate cancer cell line, by all-trans-retinoic acid treatment (ATRA), but this did not occur in the androgen-dependent cell line expressing low levels of Bcl-2.	2-octenal	171-177	BCL2 apoptosis regulator	Homo sapiens	98-103
12644474-4	2003	We observed growth arrest and apoptosis, upon decreasing Bcl-2 protein and transcript in the high Bcl-2-expressing, androgen-independent prostate cancer cell line, by all-trans-retinoic acid treatment (ATRA), but this did not occur in the androgen-dependent cell line expressing low levels of Bcl-2.	2-octenal	171-177	BCL2 apoptosis regulator	Homo sapiens	98-103
12515727-11	2003	Our findings also indicate that APL patients with FLT3 mutations may benefit from combination therapy with all-trans retinoic acid plus an FLT3 inhibitor.	2-octenal	111-116	fms related receptor tyrosine kinase 3	Homo sapiens	50-54
12021230-0	2002	Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice.	2-octenal	34-39	apolipoprotein E	Mus musculus	104-120
12139725-0	2002	Simultaneous induction of matrix metalloproteinase-9 and interleukin 8 by all-trans retinoic acid in human PL-21 and NB4 myeloid leukaemia cells.	2-octenal	78-83	matrix metallopeptidase 9	Homo sapiens	26-52
12139725-0	2002	Simultaneous induction of matrix metalloproteinase-9 and interleukin 8 by all-trans retinoic acid in human PL-21 and NB4 myeloid leukaemia cells.	2-octenal	78-83	C-X-C motif chemokine ligand 8	Homo sapiens	57-70
12632092-2	2003	We have investigated the effects of all-trans retinoic acid (atRA) on the mRNA and protein levels of ABCA1 in THP-1 cells.	2-octenal	40-45	ATP binding cassette subfamily A member 1	Homo sapiens	101-106
12616482-0	2003	All-trans retinoic acid down-regulates expression and function of beta2 integrins by human monocytes: opposite effects on monocytic cell lines.	2-octenal	4-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	66-71
12393450-6	2003	PML-RARalpha inhibits expression of C/EBPepsilon, whereas all-trans retinoic acid (tRA), a differentiating agent to which APL is particularly susceptible, induces C/EBPepsilon expression.	2-octenal	62-67	CCAAT/enhancer binding protein (C/EBP), epsilon	Mus musculus	163-175
12529666-3	2003	c-fms was constitutively and constantly expressed in all cases sensitive in vivo to all-trans retinoic acid (ATRA) and its expression was further potentiated following in vitro induction with ATRA.	2-octenal	88-93	colony stimulating factor 1 receptor	Homo sapiens	0-5
12423348-11	2002	Cells stimulated with all-trans retinoic acid to differentiate them towards a granulocytic pathway, showed a strong ( approximately 18-fold) down-regulation of intracellular cystatin F and almost abolished secreted levels of the inhibitor.	2-octenal	26-31	cystatin F	Homo sapiens	174-184
12056806-6	2002	Real-time quantitative PCR analysis confirmed an increase in ARHGAP10 expression during differentiation of HL-60 cells with all-trans-retinoic acid and hematopoietic stem cells with erythropoietin, suggesting that this gene could play a role in normal hematopoiesis.	2-octenal	128-134	Rho GTPase activating protein 10	Homo sapiens	61-69
11929748-2	2002	Initially described in a patient with all-trans retinoic acid (ATRA)-unresponsive disease, STAT5b-RARalpha resulted from an interstitial deletion on chromosome 17.	2-octenal	42-47	signal transducer and activator of transcription 5B	Homo sapiens	91-97
12148907-5	2002	In addition, IL-10 abolishes all trans retinoic acid (ATRA)-induced growth inhibition of myeloma cells.	2-octenal	33-38	interleukin 10	Homo sapiens	13-18
11929748-2	2002	Initially described in a patient with all-trans retinoic acid (ATRA)-unresponsive disease, STAT5b-RARalpha resulted from an interstitial deletion on chromosome 17.	2-octenal	42-47	retinoic acid receptor alpha	Homo sapiens	98-106
11851873-5	2002	After treatment with all-trans retinoic acid, many of the cells became tyrosinase- and dihydroxyphenylalanine-reaction-positive, changed from polygonal to dendritic in shape, and had stage III to IV melanosomes.	2-octenal	25-30	tyrosinase	Mus musculus	71-81
11943730-0	2002	Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers.	2-octenal	40-45	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	14-20
12207051-9	2002	Significant increase observed in interferon gamma inducing factor (IGIF/IL-18) mRNA expression in all-trans-retinoic acid-treated cells on day 14 and 17 did not translate to increased INF gamma expression.	2-octenal	102-108	interleukin 18	Mus musculus	67-71
12207051-9	2002	Significant increase observed in interferon gamma inducing factor (IGIF/IL-18) mRNA expression in all-trans-retinoic acid-treated cells on day 14 and 17 did not translate to increased INF gamma expression.	2-octenal	102-108	interleukin 18	Mus musculus	72-77
11886382-0	2002	Interleukin 10 abolishes the growth inhibitory effects of all-trans retinoic acid on human myeloma cells.	2-octenal	62-67	interleukin 10	Homo sapiens	0-14
11804877-0	2002	Stimulation of vascular endothelial growth factor gene transcription by all trans retinoic acid through Sp1 and Sp3 sites in human bronchioloalveolar carcinoma cells.	2-octenal	55-60	vascular endothelial growth factor A	Homo sapiens	15-49
11804877-0	2002	Stimulation of vascular endothelial growth factor gene transcription by all trans retinoic acid through Sp1 and Sp3 sites in human bronchioloalveolar carcinoma cells.	2-octenal	55-60	Sp3 transcription factor	Homo sapiens	112-115
11872149-0	2002	4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.	2-octenal	64-69	aldehyde dehydrogenase 1 family member A1	Homo sapiens	108-115
12207051-11	2002	The function of TNF alpha, IGIF/IL-18 and MIF in all-trans-retinoic acid-treated cells during ES differentiation and apoptosis is still speculatory.	2-octenal	53-59	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	42-45
11588034-6	2001	The addition of all-trans retinoic acid also enhanced this granulocytic differentiation of the cultured C/EBPalpha(-/-) cells, indicating that the activated retinoic acid receptors can enhance granulocytic differentiation through a molecular pathway that is independent of C/EBPalpha.	2-octenal	20-25	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	104-114
11588034-6	2001	The addition of all-trans retinoic acid also enhanced this granulocytic differentiation of the cultured C/EBPalpha(-/-) cells, indicating that the activated retinoic acid receptors can enhance granulocytic differentiation through a molecular pathway that is independent of C/EBPalpha.	2-octenal	20-25	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	273-283
11588055-8	2001	Taken together, these results suggest that erythropoiesis and granulopoiesis require diminished and enhanced RARalpha activities, respectively, which at physiological all-trans-retinoic acid (RA) concentrations may be accomplished by reciprocal effects of EPO and myelomonocytic growth factors on its expression.	2-octenal	171-177	retinoic acid receptor, alpha	Mus musculus	109-117
11603003-0	2001	13cis- and all-trans retinoic acid have antiproliferative effects on CML cells and render IFN alpha antiproliferative potency after combined treatment in vitro.	2-octenal	15-20	interferon alpha 1	Homo sapiens	90-99
11432447-1	2001	It has been shown that all-trans retinoic acid induces prematurely hepatic glucokinase mRNA in ten days-old neonatal rat hepatocytes, however, this effect could be related to the capacity of the retinoid to promote a more differentiated state of the hepatocyte.	2-octenal	27-32	glucokinase	Rattus norvegicus	75-86
11432447-2	2001	In this report we demonstrate that physiological concentrations of all-trans retinoic acid stimulate glucokinase activity in both mature fully differentiated hepatocytes and at the onset of the induction of the enzyme in 15 to 17 days-old neonatal hepatocytes.	2-octenal	71-76	glucokinase	Rattus norvegicus	101-112
10970819-0	2000	Insulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with all-trans-retinoic acid treatment.	2-octenal	137-143	insulin like growth factor binding protein 6	Homo sapiens	0-44
11313272-7	2001	Conversely, all-trans retinoic acid significantly decreased survivin protein levels in HL-60, OCI-AML3, and NB-4 cells within 96 hours, parallel to the induction of myelomonocytic differentiation.	2-octenal	16-21	RUNX family transcription factor 2	Homo sapiens	98-102
11172538-6	2001	Targeting of the PLZF-RARalpha-bound corepressor complexes using a combination of all-trans retinoic acid (ATRA) and deacetylase inhibitors has shown that the repression of target genes can be relieved, allowing differentiation of the cells.	2-octenal	86-91	zinc finger and BTB domain containing 16	Homo sapiens	17-21
11172538-6	2001	Targeting of the PLZF-RARalpha-bound corepressor complexes using a combination of all-trans retinoic acid (ATRA) and deacetylase inhibitors has shown that the repression of target genes can be relieved, allowing differentiation of the cells.	2-octenal	86-91	retinoic acid receptor alpha	Homo sapiens	22-30
10979975-0	2000	Maintenance of retinoic acid receptor alpha pools by granulocyte colony-stimulating factor and lithium chloride in all-trans retinoic acid-treated WEHI-3B leukemia cells: relevance to the synergistic induction of terminal differentiation.	2-octenal	119-124	retinoic acid receptor, alpha	Mus musculus	15-43
11306050-4	2001	Expression of ALDH3A1 by stable transfection in V79 cells conferred a high level of protection against growth inhibition by the medium-chain length aldehyde substrates with highest substrate activity, including hexanal, trans-2-hexenal, trans-2-octenal, trans-2-nonenal, and 4-hydroxy-2-nonenal (HNE).	2-octenal	237-252	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	14-21
10874126-0	2000	Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation.	2-octenal	72-78	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	24-39
10974019-0	2000	c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid.	2-octenal	52-57	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
10748128-5	2000	Our results indicate that RARgamma is the principle receptor contributing to all-trans-retinoic acid (RA)-mediated growth arrest in this system.	2-octenal	81-87	retinoic acid receptor, gamma	Mus musculus	26-34
10840941-5	2000	Our experimental results clearly indicate that All Trans Retinoic Acid (ATRA) inhibit metastatic potential of highly metastatic B16F10 melanoma cells by 1) downregulating the cell surface integrin receptors against ECM proteins specially laminin and vitronectin and 2) by inhibiting the 72 kd collagenase activity.	2-octenal	51-56	vitronectin	Mus musculus	250-267
10870476-4	2000	In the presence of high levels of all-trans retinoic acid (ATRA), both PML-dependent apoptotic mechanisms and myeloid-specific gene expression programs are reactivated.	2-octenal	38-43	PML nuclear body scaffold	Homo sapiens	71-74
11059564-0	2000	Inhibition of the cytochrome P-450 modulates all-trans-retinoic acid-induced differentiation and apoptosis of HL-60 cells.	2-octenal	49-55	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	18-34
10720132-7	2000	Comparing HLA frequencies, clinical features at diagnosis and clinical outcome of the 64 patients homogeneously treated with all-trans retinoic acid and idarubicin (AIDA protocol) we observed a statistically significant association between HLA-B*13 and risk of relapse by univariate and multivariate regression analysis.	2-octenal	129-134	major histocompatibility complex, class I, B	Homo sapiens	240-245
10699467-10	2000	The decrease in GnT-V and the corresponding increase in GnT-III activities were also found after the cells were treated with all-trans retinoic acid (ATRA), and the mechanism of this might be different from that in the cell cycle.	2-octenal	129-134	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	16-21
10699467-10	2000	The decrease in GnT-V and the corresponding increase in GnT-III activities were also found after the cells were treated with all-trans retinoic acid (ATRA), and the mechanism of this might be different from that in the cell cycle.	2-octenal	129-134	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	56-63
9989778-8	1999	All-trans retinoic acid was effective in reducing the levels of focal adhesion kinase and paxillin protein.	2-octenal	4-9	paxillin	Homo sapiens	90-98
10863413-0	1999	Effects of all-trans retinoic acid and interferon-gamma on expression of RAR beta gene in Tca8113 cells.	2-octenal	15-20	retinoic acid receptor beta	Homo sapiens	73-81
10523855-2	1999	We previously reported that all-trans retinoic acid (RA) triggers terminal differentiation in the human embryonal carcinoma cell line NTERA-2 clone D1 (NT2/D1), through an RARgamma dependent pathway.	2-octenal	32-37	retinoic acid receptor gamma	Homo sapiens	172-180
10456672-0	1999	Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid leukaemia CD34 positive cells.	2-octenal	14-19	BCL2 apoptosis regulator	Homo sapiens	91-96
10456672-0	1999	Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid leukaemia CD34 positive cells.	2-octenal	14-19	CD34 molecule	Homo sapiens	124-128
10024510-1	1999	To investigate which retinoid receptors are critical in the regulation by all-trans-retinoic acid (RA) of the mucin genes MUC2, MUC5AC and MUC5B in cultured normal human tracheobronchial epithelial (NHTBE) cells, we used pan-RAR-, pan-RXR- and RAR- isotype (alpha, beta and gamma)-selective agonists and RARalpha- and RARgamma-selective antagonists (RAR is RA receptor and RXR is retinoid X receptor).	2-octenal	78-84	LOC100508689	Homo sapiens	110-115
9804832-8	1998	These experiments define the following pathway as a major pathway in the synergistic growth inhibition of MCF-7 cells by all-trans-retinoic acid plus interferon-alpha: all-trans-retinoic acid + interferon-alpha --> upward arrow double-stranded RNA-dependent protein kinase --> downward arrow c-Myc --> cell growth inhibition.	2-octenal	125-131	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	298-303
9973197-0	1999	Phosphoinositide 3-kinase activity is essential for all-trans-retinoic acid-induced granulocytic differentiation of HL-60 cells.	2-octenal	56-62	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	0-25
9738944-2	1998	Using rat muscle PAD cDNA as a probe, we obtained two novel cDNAs, PAD-R11 and PAD-R4, from immortalized rat keratinocytes treated with all-trans retinoic acid.	2-octenal	140-145	peptidyl arginine deiminase 1	Rattus norvegicus	67-74
9778041-2	1998	PML/RAR alpha expression is linked to leukemogenesis and to clinical sensitivity to all-trans retinoic acid (RA).	2-octenal	88-93	PML nuclear body scaffold	Homo sapiens	0-13
9740237-0	1998	Retinoic acid receptors regulate expression of retinoic acid 4-hydroxylase that specifically inactivates all-trans retinoic acid in human keratinocyte HaCaT cells.	2-octenal	109-114	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	47-74
11189487-0	1998	[Tissue factor expression during all-trans retinoic acid or arsenic trioxide treatment in acute promyelocytic leukemia].	2-octenal	37-42	coagulation factor III, tissue factor	Homo sapiens	1-14
9738944-2	1998	Using rat muscle PAD cDNA as a probe, we obtained two novel cDNAs, PAD-R11 and PAD-R4, from immortalized rat keratinocytes treated with all-trans retinoic acid.	2-octenal	140-145	peptidyl arginine deiminase 4	Rattus norvegicus	79-85
9488621-1	1998	Acute myeloid leukaemia (AML) of FAB subtype M3 is associated with t(15;17)(q22;q21) and a relatively good prognosis when treated with all-trans retinoic acid (ATRA) and combination chemotherapy.	2-octenal	139-144	FA complementation group B	Homo sapiens	33-36
9792441-2	1998	Exposure of Tera-2 cells to all-trans retinoic acid for up to 16 days led to a decrease of CD95 ligand expression when compared to the control conditions, whereas expression of both CD95 isoforms increased.	2-octenal	32-37	Fas cell surface death receptor	Homo sapiens	91-95
9792441-2	1998	Exposure of Tera-2 cells to all-trans retinoic acid for up to 16 days led to a decrease of CD95 ligand expression when compared to the control conditions, whereas expression of both CD95 isoforms increased.	2-octenal	32-37	Fas cell surface death receptor	Homo sapiens	182-186
9718082-8	1998	An increase in the level of immunophenotypic expression of wild type p53 was also noted after treatment with all trans retinoic acid and 9-cis retinoic acid.	2-octenal	113-118	tumor protein p53	Homo sapiens	69-72
9447832-0	1997	Induction of thrombospondin-1 by all-trans retinoic acid modulates growth and differentiation of HL-60 myeloid leukemia cells.	2-octenal	37-42	thrombospondin 1	Homo sapiens	13-29
9428648-1	1997	All-trans retinoic acid (10(-7) M) induces cell-cell communication and the expression of the gap junction protein connexin43 in mouse F9 teratocarcinoma cells.	2-octenal	4-9	gap junction protein, alpha 1	Mus musculus	114-124
9242531-0	1997	Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy.	2-octenal	91-96	retinoic acid receptor alpha	Homo sapiens	27-36
9398654-3	1997	However, in follicular thyroid carcinoma cell lines FTC-133 and FTC-238, treatment with 1 microM all-trans retinoic acid (RA) markedly increased NIS mRNA levels.	2-octenal	101-106	solute carrier family 5 member 5	Rattus norvegicus	145-148
9357979-0	1997	Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.	2-octenal	25-30	homeobox B cluster	Homo sapiens	69-73
9357979-0	1997	Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.	2-octenal	25-30	homeobox C cluster	Homo sapiens	78-82
9193684-2	1997	We previously demonstrated that an ecto-form NAD+ glycohydrolase (NADase) activity induced by all-trans retinoic acid in HL-60 cells is due to the extracellular domain of CD38.	2-octenal	98-103	CD38 molecule	Homo sapiens	171-175
9277051-0	1997	Prediction of growth sensitivity of acute promyelocytic leukemia cells to granulocyte colony-stimulating factor using 7AAD/PY during administration of all-trans retinoic acid.	2-octenal	155-160	colony stimulating factor 3	Homo sapiens	74-111
9186002-4	1997	Here we have studied the activation and induction of IFN-specific transcription factors signal transducer and activator of transcription (STAT) 1, STAT2, and p48 in all-trans-retinoic acid (ATRA)-differentiated myeloid leukemia cells using promyelocytic NB4, myeloblastic HL-60, and monoblastic U937 cells as model systems.	2-octenal	66-71	interferon alpha 1	Homo sapiens	53-56
9186002-4	1997	Here we have studied the activation and induction of IFN-specific transcription factors signal transducer and activator of transcription (STAT) 1, STAT2, and p48 in all-trans-retinoic acid (ATRA)-differentiated myeloid leukemia cells using promyelocytic NB4, myeloblastic HL-60, and monoblastic U937 cells as model systems.	2-octenal	66-71	signal transducer and activator of transcription 1	Homo sapiens	88-145
9028332-0	1997	Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells.	2-octenal	38-43	signal transducer and activator of transcription 1	Homo sapiens	0-5
8690916-7	1996	However, noninflammatory stimuli induced qualitatively similar changes in M phi and EC; all-trans retinoic acid and prostaglandin E up-regulated surface TM, and PMA decreased TM expression.	2-octenal	92-97	thrombomodulin	Homo sapiens	153-155
8923783-1	1996	Granulocyte colony-stimulating factor (G-CSF) enhances the differentiation of acute promyelocytic leukemia (APL) cells induced by all-trans retinoic acid (ATRA) in vitro.	2-octenal	134-139	colony stimulating factor 3	Homo sapiens	0-37
8923783-1	1996	Granulocyte colony-stimulating factor (G-CSF) enhances the differentiation of acute promyelocytic leukemia (APL) cells induced by all-trans retinoic acid (ATRA) in vitro.	2-octenal	134-139	colony stimulating factor 3	Homo sapiens	39-44
8646757-0	1996	Regulation of differentiation and keratin 10 expression by all-trans retinoic acid during the estrous cycle in the rat vaginal epithelium.	2-octenal	63-68	keratin 10	Rattus norvegicus	34-44
8806687-9	1996	However, following all trans retinoic acid treatment of NB4 cells a significant relocalisation of PIC1 and PML is observed.	2-octenal	23-28	small ubiquitin like modifier 1	Homo sapiens	98-102
8806687-9	1996	However, following all trans retinoic acid treatment of NB4 cells a significant relocalisation of PIC1 and PML is observed.	2-octenal	23-28	PML nuclear body scaffold	Homo sapiens	107-110
8754760-0	1996	Differential growth regulation by all-trans retinoic acid is determined by protein kinase C alpha in human pancreatic carcinoma cells.	2-octenal	38-43	protein kinase C alpha	Homo sapiens	75-97
8589272-2	1995	Upon granulocytic differentiation with all-trans retinoic acid (ATRA) or the combination of ATRA and granulocyte-colony-stimulating factor (G-CSF), significant amounts of IL-1 beta and IL-8 mRNAs accumulated in both cell types.	2-octenal	43-48	interleukin 1 beta	Homo sapiens	171-180
8656080-10	1995	The CYP7 promoter activity was induced nearly 5-fold by all-trans-retinoic acid through sequences in the region from -200 to -129.	2-octenal	60-66	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	4-8
7536661-5	1995	Treatment of Ob cells with either IGF-I or all-trans-retinoic acid (RA) caused a time- and dose-dependent increase in IGFBP-5 messenger RNA (mRNA) levels, as determined by Northern blot analysis.	2-octenal	46-53	insulin-like growth factor binding protein 5	Rattus norvegicus	118-125
8601734-1	1996	Application of all-trans retinoic acid to human skin for 4 d under occlusion produces a marked increase in retinoic acid 4-hydroxylase activity.	2-octenal	19-24	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	107-134
8547658-8	1996	Dexamethasone increased, while all-trans retinoic acid reduced, IL-6R but not gp130 mRNA expression.	2-octenal	35-40	interleukin 6 receptor	Homo sapiens	64-69
7492559-1	1995	Cellular retinoic acid binding protein-I (CRABP-I) and cellular retinoic acid binding protein-II (CRABP-II) are highly homologous, 15 kDa proteins which bind all-trans-retinoic acid.	2-octenal	162-167	cellular retinoic acid binding protein 1	Homo sapiens	0-40
7492559-1	1995	Cellular retinoic acid binding protein-I (CRABP-I) and cellular retinoic acid binding protein-II (CRABP-II) are highly homologous, 15 kDa proteins which bind all-trans-retinoic acid.	2-octenal	162-167	cellular retinoic acid binding protein 1	Homo sapiens	42-49
7492559-1	1995	Cellular retinoic acid binding protein-I (CRABP-I) and cellular retinoic acid binding protein-II (CRABP-II) are highly homologous, 15 kDa proteins which bind all-trans-retinoic acid.	2-octenal	162-167	cellular retinoic acid binding protein 2	Homo sapiens	55-96
7492559-1	1995	Cellular retinoic acid binding protein-I (CRABP-I) and cellular retinoic acid binding protein-II (CRABP-II) are highly homologous, 15 kDa proteins which bind all-trans-retinoic acid.	2-octenal	162-167	cellular retinoic acid binding protein 2	Homo sapiens	98-106
7644503-1	1995	Disruption of retinoic acid receptor (RAR) gamma in F9 embryonal carcinoma cells leads to aberrent differentiation and reduced activation of expression of several all-trans-retinoic acid (RA)-induced genes.	2-octenal	167-173	retinoic acid receptor alpha	Homo sapiens	14-36
7644503-1	1995	Disruption of retinoic acid receptor (RAR) gamma in F9 embryonal carcinoma cells leads to aberrent differentiation and reduced activation of expression of several all-trans-retinoic acid (RA)-induced genes.	2-octenal	167-173	retinoic acid receptor alpha	Homo sapiens	38-41
7698301-3	1995	This study shows that all trans retinoic acid significantly enhances this activity by increasing production of tumour necrosis factor and gamma interferon, which results in enhanced expression of the p55 part of the interleukin 2 receptor.	2-octenal	26-31	interleukin 2 receptor subunit alpha	Homo sapiens	200-203
7533656-4	1995	Systemic treatment of mice with all-trans retinoic acid, 13-cis retinoic acid, 9-cis retinoic acid, IFN alpha or 1,25(OH)2D3 significantly decreased tumor cell-induced angiogenesis (TIA).	2-octenal	36-41	interferon alpha	Mus musculus	100-109
7998926-7	1994	The induction of RAR-beta and CRABP II by all-trans retinoic acid was maintained in the subsequent absence of all-trans retinoic acid, whereas induction by 9-cis retinoic acid was dependent on its continued presence in the culture medium.	2-octenal	46-51	retinoic acid receptor beta	Homo sapiens	17-25
7998926-7	1994	The induction of RAR-beta and CRABP II by all-trans retinoic acid was maintained in the subsequent absence of all-trans retinoic acid, whereas induction by 9-cis retinoic acid was dependent on its continued presence in the culture medium.	2-octenal	46-51	cellular retinoic acid binding protein 2	Homo sapiens	30-38
7998926-7	1994	The induction of RAR-beta and CRABP II by all-trans retinoic acid was maintained in the subsequent absence of all-trans retinoic acid, whereas induction by 9-cis retinoic acid was dependent on its continued presence in the culture medium.	2-octenal	114-119	retinoic acid receptor beta	Homo sapiens	17-25
7524761-0	1994	All-trans retinoic acid directly inhibits granulocyte colony-stimulating factor-induced proliferation of CD34+ human hematopoietic progenitor cells.	2-octenal	4-9	colony stimulating factor 3	Homo sapiens	42-79
7524761-0	1994	All-trans retinoic acid directly inhibits granulocyte colony-stimulating factor-induced proliferation of CD34+ human hematopoietic progenitor cells.	2-octenal	4-9	CD34 molecule	Homo sapiens	105-109
7918317-3	1994	In HepG2 cells, addition of all-trans retinoic acid (RA) doubled apoA-I mRNA within 24 hours and protein secreted in the culture medium after 48 hours.	2-octenal	32-37	apolipoprotein A1	Homo sapiens	65-71
7949172-1	1994	The expressions of thrombomodulin (TM) and tissue factor (TF) by all-trans retinoic acid (ATRA) were studied in human leukemic cell lines including NB4 (acute promyelocytic leukemia) and U937 (monoblastic leukemia).	2-octenal	69-74	thrombomodulin	Homo sapiens	19-33
7949172-1	1994	The expressions of thrombomodulin (TM) and tissue factor (TF) by all-trans retinoic acid (ATRA) were studied in human leukemic cell lines including NB4 (acute promyelocytic leukemia) and U937 (monoblastic leukemia).	2-octenal	69-74	thrombomodulin	Homo sapiens	35-37
7949172-1	1994	The expressions of thrombomodulin (TM) and tissue factor (TF) by all-trans retinoic acid (ATRA) were studied in human leukemic cell lines including NB4 (acute promyelocytic leukemia) and U937 (monoblastic leukemia).	2-octenal	69-74	coagulation factor III, tissue factor	Homo sapiens	43-56
7949172-1	1994	The expressions of thrombomodulin (TM) and tissue factor (TF) by all-trans retinoic acid (ATRA) were studied in human leukemic cell lines including NB4 (acute promyelocytic leukemia) and U937 (monoblastic leukemia).	2-octenal	69-74	coagulation factor III, tissue factor	Homo sapiens	58-60
8014577-8	1994	The alkenals 2,4-decadienal and 2-octenal were tested and shown to induce IL-1 beta release while their saturated homologues had no effect.	2-octenal	32-41	interleukin 1 beta	Homo sapiens	74-83
8207983-1	1994	The current treatment of acute promyelocytic leukemia (APL, also called AML3 subtype) is focused on differentiating agents such as the vitamin A derivative all-trans retinoic acid (ATRA).	2-octenal	160-165	RUNX family transcription factor 2	Homo sapiens	72-76
8194491-1	1994	Retinoids (all trans and 9-cis retinoic acid) are pleiotropic regulators of cell fate, and have been shown to regulate the expression of helix loop helix transcription factors (e.g MyoD, myogenin and Myf-5) that control myogenic differentiation.	2-octenal	15-20	myogenic differentiation 1	Homo sapiens	181-185
8194491-1	1994	Retinoids (all trans and 9-cis retinoic acid) are pleiotropic regulators of cell fate, and have been shown to regulate the expression of helix loop helix transcription factors (e.g MyoD, myogenin and Myf-5) that control myogenic differentiation.	2-octenal	15-20	myogenin	Homo sapiens	187-195
8194491-1	1994	Retinoids (all trans and 9-cis retinoic acid) are pleiotropic regulators of cell fate, and have been shown to regulate the expression of helix loop helix transcription factors (e.g MyoD, myogenin and Myf-5) that control myogenic differentiation.	2-octenal	15-20	myogenic factor 5	Homo sapiens	200-205
8142457-5	1994	The Ki values for (E)-2-octenal and (E)-3-nonen-2-one toward selected alpha- and mu-class of rat liver glutathione S-transferase isozymes were determined and both of these compounds competitively inhibited all five of the rat liver glutathione S-transferase isozymes examined.	2-octenal	18-31	hematopoietic prostaglandin D synthase	Rattus norvegicus	103-128
8142457-5	1994	The Ki values for (E)-2-octenal and (E)-3-nonen-2-one toward selected alpha- and mu-class of rat liver glutathione S-transferase isozymes were determined and both of these compounds competitively inhibited all five of the rat liver glutathione S-transferase isozymes examined.	2-octenal	18-31	hematopoietic prostaglandin D synthase	Rattus norvegicus	232-257
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	2-octenal	50-55	interleukin 1 alpha	Homo sapiens	116-120
8301142-9	1994	13-cis-retinoic acid, retinol, retinaldehyde, all-trans etretin, Ro 13-6298, and 9-cis retinoic acid also inhibited IL-1-induced IL-6 production.	2-octenal	50-55	interleukin 6	Homo sapiens	129-133
7815831-1	1994	The current treatment of acute promyelocytic leukemia (APL, also called AML3 subtype) is focused on differentiating agents such as the vitamin A derivative all-trans retinoic acid (ATRA).	2-octenal	160-165	RUNX family transcription factor 2	Homo sapiens	72-76
8148817-3	1994	When delipidated apo B was treated with linoleic acid 13-mono-hydroperoxide (LOOH) and trans-2-octenal (octenal), apo B became fluorescent and its Lys and histidine (His) residues were decreased.	2-octenal	87-102	apolipoprotein B	Mus musculus	17-22
8385314-2	1993	We found that in Drosophila SL-3 cells that are devoid of endogenous RARs and RXRs the presence of RAR is sufficient to confer a response to all-trans retinoic acid (RA).	2-octenal	145-150	retinoic acid receptor alpha	Homo sapiens	69-72
1312497-4	1992	Recently, we demonstrated that all-trans retinoic acid (RA) serves as a "pro-hormone" to the isomer 9-cis RA, which is a high-affinity ligand for the human RXR alpha.	2-octenal	35-40	retinoid X receptor alpha	Homo sapiens	156-165
7507222-3	1993	All-trans retinoic acid weakly down-regulated cell surface protectin on K-562, while 1,25(OH)2-vitamin D3 produced such effect on HL-60 cells.	2-octenal	4-9	CD59 molecule (CD59 blood group)	Homo sapiens	59-68
1336225-6	1992	We report that L-2-amino-3-phosphonopropionic acid (L-AP3), an antagonist of trans-ACPD-stimulated phosphoinositide hydrolysis, does not inhibit the physiological effects of trans-ACPD in area CA1 at concentrations that maximally inhibit trans-ACPD-stimulated phosphoinositide hydrolysis in this region.	2-octenal	77-82	homer scaffold protein 2	Homo sapiens	83-87
1332684-7	1992	The overexpressed receptor specifically bound all-trans-retinoic acid (RA) and the synthetic retinoid CD367 with high affinity (Kd 0.15 nM and 0.23 nM respectively).	2-octenal	50-56	C-type lectin domain family 4 member A	Homo sapiens	102-107
1797449-6	1991	The addition of interleukin-6 to all-trans retinoic acid-treated cultures of HL-60 human myeloid leukaemia cells significantly enhanced the desired antiproliferation effect of all-trans retinoic acid.	2-octenal	37-42	interleukin 6	Homo sapiens	16-29
1661301-0	1991	All-trans retinoic acid modulates the retinoic acid receptor-alpha in promyelocytic cells.	2-octenal	4-9	retinoic acid receptor alpha	Homo sapiens	38-66