PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21139430-5	2010	Here, we discuss results from global transcript profiling of white leaf tissues of Arabidopsis that are blocked at the PDS step in three different ways--two by mutation (immutans & pds3) and one by inhibitor treatment (norflurazon).	norflurazone	223-234	phytoene desaturase 3	Arabidopsis thaliana	119-122
19363094-9	2009	In addition, we show that a semidominant chli1 mutant allele and the chli1/chli1 chli2/chli2 double mutant accumulated Lhcb1 transcripts when treated with the herbicide norflurazon, indicating that knocking out the CHLI activity causes the genome-uncoupled phenotype.	norflurazone	169-180	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	41-46
20143129-8	2010	The ZAT10 gene encodes a transcription factor and its expression is down-regulated by norflurazon treatment in wild type.	norflurazone	86-97	salt tolerance zinc finger	Arabidopsis thaliana	4-9
19951003-7	2009	Analysis of the expression of omega(3) FAD3 and omega(3) FAD7 genes in norflurazon treated plants indicate that omega(3) FAD7 and omega(3) FAD3 desaturases are controlled at the post-transcriptional level.	norflurazone	71-82	omega-3 fatty acid desaturase, endoplasmic reticulum	Glycine max	39-43
19951003-7	2009	Analysis of the expression of omega(3) FAD3 and omega(3) FAD7 genes in norflurazon treated plants indicate that omega(3) FAD7 and omega(3) FAD3 desaturases are controlled at the post-transcriptional level.	norflurazone	71-82	omega-3 fatty acid desaturase, chloroplastic	Glycine max	57-61
19951003-7	2009	Analysis of the expression of omega(3) FAD3 and omega(3) FAD7 genes in norflurazon treated plants indicate that omega(3) FAD7 and omega(3) FAD3 desaturases are controlled at the post-transcriptional level.	norflurazone	71-82	omega-3 fatty acid desaturase, chloroplastic	Glycine max	121-125
19951003-7	2009	Analysis of the expression of omega(3) FAD3 and omega(3) FAD7 genes in norflurazon treated plants indicate that omega(3) FAD7 and omega(3) FAD3 desaturases are controlled at the post-transcriptional level.	norflurazone	71-82	omega-3 fatty acid desaturase, endoplasmic reticulum	Glycine max	139-143
19363094-9	2009	In addition, we show that a semidominant chli1 mutant allele and the chli1/chli1 chli2/chli2 double mutant accumulated Lhcb1 transcripts when treated with the herbicide norflurazon, indicating that knocking out the CHLI activity causes the genome-uncoupled phenotype.	norflurazone	169-180	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	69-74
19363094-9	2009	In addition, we show that a semidominant chli1 mutant allele and the chli1/chli1 chli2/chli2 double mutant accumulated Lhcb1 transcripts when treated with the herbicide norflurazon, indicating that knocking out the CHLI activity causes the genome-uncoupled phenotype.	norflurazone	169-180	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	69-74
19363094-9	2009	In addition, we show that a semidominant chli1 mutant allele and the chli1/chli1 chli2/chli2 double mutant accumulated Lhcb1 transcripts when treated with the herbicide norflurazon, indicating that knocking out the CHLI activity causes the genome-uncoupled phenotype.	norflurazone	169-180	magnesium chelatase i2	Arabidopsis thaliana	81-86
19363094-9	2009	In addition, we show that a semidominant chli1 mutant allele and the chli1/chli1 chli2/chli2 double mutant accumulated Lhcb1 transcripts when treated with the herbicide norflurazon, indicating that knocking out the CHLI activity causes the genome-uncoupled phenotype.	norflurazone	169-180	magnesium chelatase i2	Arabidopsis thaliana	87-92
32689394-7	2007	Herbicide treatments that inhibit carotenoid biosynthetic enzymes in wildtype and ccr2 etiolated seedlings were used to demonstrate that the loss of the PLB in ccr2 mutants is a result of perturbations in carotenoid accumulation, not indirect secondary effects, as PLB formation could be restored in ccr2 mutants treated with norflurazon.	norflurazone	326-337	CRINKLY4 related 2	Arabidopsis thaliana	160-164
32689394-7	2007	Herbicide treatments that inhibit carotenoid biosynthetic enzymes in wildtype and ccr2 etiolated seedlings were used to demonstrate that the loss of the PLB in ccr2 mutants is a result of perturbations in carotenoid accumulation, not indirect secondary effects, as PLB formation could be restored in ccr2 mutants treated with norflurazon.	norflurazone	326-337	CRINKLY4 related 2	Arabidopsis thaliana	160-164
12374304-7	2002	Treatment of soybean cotyledons with norflurazon also induced expression of Aox1.	norflurazone	37-48	ubiquinol oxidase 1, mitochondrial	Glycine max	76-80
14579534-2	2003	From the tetrad analysis result of hybridizations of psbA mutant with wild strains CC-124 and nfr mutant, it have been demonstrated that the sensitivity of psbA mutated strain to norflurazon under photoautotrophic condition is due to its multiple effect whereas the chloroplast genome under the mixotrophic situation also gives some effect for resistance to norflurazon.	norflurazone	179-190	photosystem II protein D1	Chlamydomonas reinhardtii	53-57
14579534-2	2003	From the tetrad analysis result of hybridizations of psbA mutant with wild strains CC-124 and nfr mutant, it have been demonstrated that the sensitivity of psbA mutated strain to norflurazon under photoautotrophic condition is due to its multiple effect whereas the chloroplast genome under the mixotrophic situation also gives some effect for resistance to norflurazon.	norflurazone	179-190	photosystem II protein D1	Chlamydomonas reinhardtii	156-160
14579534-2	2003	From the tetrad analysis result of hybridizations of psbA mutant with wild strains CC-124 and nfr mutant, it have been demonstrated that the sensitivity of psbA mutated strain to norflurazon under photoautotrophic condition is due to its multiple effect whereas the chloroplast genome under the mixotrophic situation also gives some effect for resistance to norflurazon.	norflurazone	358-369	photosystem II protein D1	Chlamydomonas reinhardtii	53-57
14579534-2	2003	From the tetrad analysis result of hybridizations of psbA mutant with wild strains CC-124 and nfr mutant, it have been demonstrated that the sensitivity of psbA mutated strain to norflurazon under photoautotrophic condition is due to its multiple effect whereas the chloroplast genome under the mixotrophic situation also gives some effect for resistance to norflurazon.	norflurazone	358-369	photosystem II protein D1	Chlamydomonas reinhardtii	156-160
17156966-7	2007	The introduced CYP1A1 enhanced the metabolism of chlorotoluron and norflurazon.	norflurazone	67-78	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	15-21
16315095-5	2005	CYP2C49 rice plants showed tolerance towards 13 herbicides, including chlortoluron (100 microM), norflurazon (0.5 microM), amiprofos-methyl (2.5 microM), alachlor (0.8 microM), and isoxaben (1 microM).	norflurazone	97-108	cytochrome P450 2C49	Sus scrofa	0-7
15853388-5	2005	CYP2B6 rice plants were able to grow in the presence of 13 out of 17 herbicides: five chloroacetamides and mefenacet, pyributicarb, amiprofos-methyl, trifluralin, pendimethalin, norflurazon, and chlorotoluron.	norflurazone	178-189	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-6
12068118-5	2002	In both green- and norflurazon-treated (chlorophyll-deficient) seedlings, cryptochrome activity is fairly uniform throughout its range of maximal response (390-480 nm), with no sharply defined peak at 450 nm; however, activity at longer wavelengths was disproportionately enhanced in CRY1-overexpressing seedlings as compared with wild type.	norflurazone	19-30	cryptochrome 1	Arabidopsis thaliana	284-288
12430024-4	2002	Precursor accumulation after inhibition of phytoene desaturase (Pds) activity by norflurazon indicated an increased phytoene biosynthetic capacity in mycorrhizal roots of all species analyzed.	norflurazone	81-92	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Zea mays	43-62
12430024-4	2002	Precursor accumulation after inhibition of phytoene desaturase (Pds) activity by norflurazon indicated an increased phytoene biosynthetic capacity in mycorrhizal roots of all species analyzed.	norflurazone	81-92	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Zea mays	64-67
12139011-8	2002	In addition, elimination of a promotive plastid signal by Norflurazon-induced photobleaching of plastids had no effect on HEMA2 expression while being required for normal white-light induction of HEMA1.	norflurazone	58-69	Glutamyl-tRNA reductase family protein	Arabidopsis thaliana	196-201
11352459-5	2001	The GLO transcript was almost undetectable in seedlings in which chloroplast development was impaired by photooxidation with the herbicide norflurazon.	norflurazone	139-150	peroxisomal (S)-2-hydroxy-acid oxidase-like	Nicotiana tabacum	4-7
12000679-7	2002	Barley infected with BSMV expressing barley, rice or maize PDS fragments became photo-bleached and accumulated phytoene (the substrate for PDS) in a manner similar to plants treated with the chemical inhibitor of PDS, norflurazon.	norflurazone	218-229	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Zea mays	59-62
16228450-1	2000	The chloroplast photo-oxidation and the expression of the Cab gene Lhcb1, encoding the Lhcb1 light-harvesting chlorophyll a/b-protein of PS II, have been studied in leaf cells of maize treated with the two bleaching herbicides norflurazon and amitrole and of the two carotenoid-free mutants vp9 and vp2 grown under high photodamaging light.	norflurazone	227-238	chlorophyll a-b binding protein, chloroplastic	Zea mays	67-72
11052718-3	2000	Whereas norflurazon is a potent inhibitor of phytoene desaturase (PDS) (I(50) = 0.12 microM) but not of zeta-carotene desaturase (ZDS) (I(50) = 144 microM), J852 inhibits both PDS (I(50) = 23 microM) and ZDS (I(50) = 49 microM).	norflurazone	8-19	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Capsicum annuum	45-64
10794528-6	2000	Furthermore, AtZFP1 expression does not depend on active photosynthesis as shown by analysis of plants grown on the carotenoid biosynthetic inhibitor norflurazon.	norflurazone	150-161	zinc-finger protein 1	Arabidopsis thaliana	13-19
8485401-4	1993	Expression of both genes is induced in seedlings of the phytoene-accumulating mutant ghost and in wild-type seedlings treated with the Pds inhibitor norflurazon.	norflurazone	149-160	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum	135-138
7696878-7	1995	Expression of ATH1 does not require the presence of active chloroplasts because photooxidative destruction of the chloroplast by norflurazon treatment did not influence the ATH1 mRNA level.	norflurazone	129-140	homeobox protein ATH1	Arabidopsis thaliana	14-18
35177117-9	2022	NFZ-induced inhibition of PHYTOENE DESATURASE (PDS) activity caused higher phytoene accumulation in younger crtiso leaves compared to WT indicating a continued substrate supply from the methylerythritol 4-phosphate (MEP) pathway.	norflurazone	0-3	phytoene desaturase 3	Arabidopsis thaliana	26-45
34768794-8	2021	Genes for these GUN1-interacting proteins showed different fluctuations in the WT and gun1 mutant under norflurazon and lincomycin treatments.	norflurazone	104-115	s uncoupled 1	Arabidopsis thaliana	16-20
34768794-8	2021	Genes for these GUN1-interacting proteins showed different fluctuations in the WT and gun1 mutant under norflurazon and lincomycin treatments.	norflurazone	104-115	s uncoupled 1	Arabidopsis thaliana	86-90
16663185-6	1983	Induction of nitrate reductase activity in norflurazon-treated cotyledons had an absolute requirement for NO(3) (-) and was completely inhibited by tungstate.	norflurazone	43-54	inducible nitrate reductase [NADH] 1	Glycine max	13-30
16663185-8	1983	The optimum pH for cotyledon nitrate reductase activity from norflurazon-treated seedlings was at pH 7.5, and near that for root nitrate reductase activity, whereas the optimum pH for nitrate reductase activity from greening cotyledons was pH 6.5.	norflurazone	61-72	chalcone reductase CHR1	Glycine max	37-46
16663185-8	1983	The optimum pH for cotyledon nitrate reductase activity from norflurazon-treated seedlings was at pH 7.5, and near that for root nitrate reductase activity, whereas the optimum pH for nitrate reductase activity from greening cotyledons was pH 6.5.	norflurazone	61-72	chalcone reductase CHR1	Glycine max	137-146
16663185-8	1983	The optimum pH for cotyledon nitrate reductase activity from norflurazon-treated seedlings was at pH 7.5, and near that for root nitrate reductase activity, whereas the optimum pH for nitrate reductase activity from greening cotyledons was pH 6.5.	norflurazone	61-72	inducible nitrate reductase [NADH] 1	Glycine max	29-46
16663185-9	1983	Induction of root nitrate reductase activity was also inhibited by tungstate and was dependent on the presence of NO(3) (-), further indicating that the isoform of nitrate reductase induced in norflurazon-treated cotyledons is the same or similar to that found in roots.	norflurazone	193-204	chalcone reductase CHR1	Glycine max	26-35
16663185-9	1983	Induction of root nitrate reductase activity was also inhibited by tungstate and was dependent on the presence of NO(3) (-), further indicating that the isoform of nitrate reductase induced in norflurazon-treated cotyledons is the same or similar to that found in roots.	norflurazone	193-204	chalcone reductase CHR1	Glycine max	172-181
32963291-6	2020	Application of inhibitors like lincomycin or norflurazon inhibits greening of seedlings and represses the expression of photosynthesis-related genes including LIGHT HARVESTING CHLOROPHYLL A/B BINDING PROTEIN1.2 (LHCB1.2) in the nucleus.	norflurazone	45-56	chlorophyll A/B binding protein 3	Arabidopsis thaliana	159-210
16659463-1	1976	Inhibition of Carotenoid Biosynthesis by the Herbicide SAN 9789 (4-Chloro-5-(methylamino)-2-(alpha,alpha,alpha,-trifluoro-m-tolyl)-3-(2H)pyridazinone) and Its Developmental Consequences.	norflurazone	65-149	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	55-58
16659463-2	1976	The herbicide SAN 9789 (4-chloro-5-(methylamino)-2-(alpha,alpha,alpha-trifluoro-m-tolyl-3- (2H)pyridazinone) blocks carotenoid synthesis in growing and resting cells of Euglena at concentrations of 20 to 100 mug/ml without affecting cell viability.	norflurazone	24-107	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	14-17
32963291-6	2020	Application of inhibitors like lincomycin or norflurazon inhibits greening of seedlings and represses the expression of photosynthesis-related genes including LIGHT HARVESTING CHLOROPHYLL A/B BINDING PROTEIN1.2 (LHCB1.2) in the nucleus.	norflurazone	45-56	chlorophyll A/B binding protein 3	Arabidopsis thaliana	212-219
32639635-3	2020	We performed sRNA profiling in response to norflurazon (NF) that provokes retrograde signals in A. thaliana wild type and the two retrograde signalling mutants gun1 and gun5.	norflurazone	43-54	s uncoupled 1	Arabidopsis thaliana	160-164
32639635-3	2020	We performed sRNA profiling in response to norflurazon (NF) that provokes retrograde signals in A. thaliana wild type and the two retrograde signalling mutants gun1 and gun5.	norflurazone	43-54	magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH)	Arabidopsis thaliana	169-173
31745929-7	2020	For this purpose, enzymatic metabolization of phytoene in the tissue under investigation is prevented by treatment with the bleaching herbicide norflurazon, blocking the carotenogenic pathway downstream of PSY.	norflurazone	144-155	PHYTOENE SYNTHASE	Arabidopsis thaliana	206-209
32362255-5	2020	Our results show that targeting of FC1 to chloroplasts results in increased expression of the nuclear-encoded chloroplast genes GUN4, CA1, HEMA1, LHCB2.1, CHLH after treatment with Norflurazon (NF) and that this increase correlates to FC1 gene expression and haem production measured by feedback inhibition of protochlorophyllide synthesis.	norflurazone	181-192	carbonic anhydrase 1	Homo sapiens	134-137
32362266-5	2020	Particular attention is given to the link between NEP and PEP activity and the GUN1- (Genomes Uncoupled 1) mediated chloroplast-to-nucleus retrograde communication with respect to the Deltarpo adaptive response, i.e. the increased accumulation of NEP-dependent transcripts upon depletion of PEP activity, and the editing-level changes observed in NEP-dependent transcripts, including rpoB and rpoC1, in gun1 cotyledons after norflurazon or lincomycin treatment.	norflurazone	425-436	s uncoupled 1	Arabidopsis thaliana	79-83
32362266-5	2020	Particular attention is given to the link between NEP and PEP activity and the GUN1- (Genomes Uncoupled 1) mediated chloroplast-to-nucleus retrograde communication with respect to the Deltarpo adaptive response, i.e. the increased accumulation of NEP-dependent transcripts upon depletion of PEP activity, and the editing-level changes observed in NEP-dependent transcripts, including rpoB and rpoC1, in gun1 cotyledons after norflurazon or lincomycin treatment.	norflurazone	425-436	s uncoupled 1	Arabidopsis thaliana	86-105
32362266-5	2020	Particular attention is given to the link between NEP and PEP activity and the GUN1- (Genomes Uncoupled 1) mediated chloroplast-to-nucleus retrograde communication with respect to the Deltarpo adaptive response, i.e. the increased accumulation of NEP-dependent transcripts upon depletion of PEP activity, and the editing-level changes observed in NEP-dependent transcripts, including rpoB and rpoC1, in gun1 cotyledons after norflurazon or lincomycin treatment.	norflurazone	425-436	s uncoupled 1	Arabidopsis thaliana	403-407
31850621-8	2020	Expression of the photosynthesis gene LHCB1, a retrograde signalling marker, was differentially affected in mda1-1 and/or mterf9 compared to wild-type Col-0, after treatments with inhibitors of carotenoid biosynthesis (norflurazon) or chloroplast translation (lincomycin).	norflurazone	219-230	Mitochondrial transcription termination factor family protein	Arabidopsis thaliana	108-112
27821720-6	2017	In contrast, norflurazon- or lincomycin-treated gun1-101 mutant expressing normal levels of GLK1 mRNA failed to accumulate GLK1 protein, suggesting that plastid signals directly regulate the accumulation of GLK1 protein in a GUN1-independent manner.	norflurazone	13-24	s uncoupled 1	Arabidopsis thaliana	48-52
27821720-6	2017	In contrast, norflurazon- or lincomycin-treated gun1-101 mutant expressing normal levels of GLK1 mRNA failed to accumulate GLK1 protein, suggesting that plastid signals directly regulate the accumulation of GLK1 protein in a GUN1-independent manner.	norflurazone	13-24	GBF's pro-rich region-interacting factor 1	Arabidopsis thaliana	92-96
27821720-6	2017	In contrast, norflurazon- or lincomycin-treated gun1-101 mutant expressing normal levels of GLK1 mRNA failed to accumulate GLK1 protein, suggesting that plastid signals directly regulate the accumulation of GLK1 protein in a GUN1-independent manner.	norflurazone	13-24	s uncoupled 1	Arabidopsis thaliana	225-229
23832569-10	2013	abi4, cbfA and cbp mutants showed weaker drought-tolerance after a herbicide norflurazon treatment, which indicated the physiological role of these key transcription factors.	norflurazone	77-88	nuclear transcription factor Y subunit beta	Homo sapiens	6-10
23832569-10	2013	abi4, cbfA and cbp mutants showed weaker drought-tolerance after a herbicide norflurazon treatment, which indicated the physiological role of these key transcription factors.	norflurazone	77-88	CREB binding protein	Homo sapiens	15-18