PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25176127-0	2014	Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.	A73025	0-27	TIMP metallopeptidase inhibitor 3	Homo sapiens	116-122
19614999-1	2010	Dermal mucinoses are a heterogeneous group of disorders characterized by abnormal deposition of dermal mucin, an amorphous substance composed of hyaluronic acid and sulfated glycosaminoglycans.	A73025	165-192	LOC100508689	Homo sapiens	7-12
21177248-2	2011	LPL also plays a role in the binding of lipoprotein particles to cell-surface molecules, including sulfated glycosaminoglycans (GAGs).	A73025	99-126	lipoprotein lipase	Mus musculus	0-3
23253807-19	2012	Alcian blue staining also showed abundant accumulation of sulfated glycosaminoglycans in the SOX9-induced cartilage nodules.	A73025	58-85	SRY-box transcription factor 9	Homo sapiens	93-97
22704650-4	2012	With the porcine cartilage explant, IL-1beta induced release of sulfated-glycosaminoglycan (s-GAG) and hydroxyproline release, and this induction was significantly inhibited by sesamin.	A73025	64-90	interleukin 1 beta	Rattus norvegicus	36-44
16972247-0	2006	Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells.	A73025	0-27	fibroblast growth factor 2	Rattus norvegicus	51-55
17974491-8	2008	RESULTS: Biochemical assays revealed an elevated sulfated glycosaminoglycan (GAG)/DNA ratio in mouse IVD cells that were cultured in the presence of various concentrations of mouse GDF-5(mGDF-5) protein.	A73025	49-75	growth differentiation factor 5	Mus musculus	181-186
17974491-8	2008	RESULTS: Biochemical assays revealed an elevated sulfated glycosaminoglycan (GAG)/DNA ratio in mouse IVD cells that were cultured in the presence of various concentrations of mouse GDF-5(mGDF-5) protein.	A73025	49-75	growth differentiation factor 5	Mus musculus	187-193
15878877-6	2005	The interaction of apoA-V with sulfated glycosaminoglycans was further studied by surface plasmon resonance spectroscopy.	A73025	31-58	apolipoprotein A5	Homo sapiens	19-25
1384503-1	1992	The effects of the chondroprotective drugs, sodium pentosan polysulphate (SP54) and Arteparon (glycosaminoglycan polysulphate), on the in vitro activities of the purified matrix metalloproteinases interstitial collagenase (matrix metalloproteinase 1, MMP1) and stromelysin (MMP3) were examined.	A73025	95-125	matrix metallopeptidase 1	Homo sapiens	171-249
10749566-4	2000	In the cultured metanephros deprived of sulfated glycosaminoglycans (S-GAGs), BMP4-loaded beads partially rescue growth and elongation of the ureter.	A73025	40-67	bone morphogenetic protein 4	Mus musculus	78-82
10749566-4	2000	In the cultured metanephros deprived of sulfated glycosaminoglycans (S-GAGs), BMP4-loaded beads partially rescue growth and elongation of the ureter.	A73025	69-75	bone morphogenetic protein 4	Mus musculus	78-82
8900394-2	1996	ATIII attains its full biological activity only upon binding polysulfated glycosaminoglycans, such as heparin.	A73025	61-92	serpin family C member 1	Homo sapiens	0-5
8311117-3	1994	In the present study, Alcian blue staining and immunocytochemical techniques were used to determine whether highly sulfated glycosaminoglycans (GAGs) and/or HSPG (perlecan) were also present in diffuse A beta plaques of cerebellum.	A73025	115-142	amyloid beta precursor protein	Homo sapiens	202-208
1466504-2	1992	Glycosaminoglycan polysulfate stimulated dose-dependent incorporation of [35S]methionine into protein and fibronectin, whereas incorporation of [3H]thymidine into DNA was unaffected.	A73025	0-29	fibronectin 1	Canis lupus familiaris	106-117
1466504-3	1992	Total fibronectin, extradomain-A fibronectin, and keratan sulfate content were high in chondrocyte cultures treated with glycosaminoglycan polysulfate.	A73025	121-150	fibronectin 1	Canis lupus familiaris	6-17
1466504-3	1992	Total fibronectin, extradomain-A fibronectin, and keratan sulfate content were high in chondrocyte cultures treated with glycosaminoglycan polysulfate.	A73025	121-150	fibronectin 1	Canis lupus familiaris	33-44
12923462-13	2003	Sulfated-glycosaminoglycan increase was greatest at day 7, increasing by 1.3-, 2.1-, and 3.6-fold with recombinant human bone morphogenetic protein-2 treatments of 10, 100, and 1000 ng/mL, respectively.	A73025	0-26	bone morphogenetic protein 2	Homo sapiens	121-149
12625842-6	2003	However, enzymatic and chemical depletion of sulfated glycosaminoglycans from the Y-79 cell cultures by heparitinase and chlorate treatments decreased the degree of 125I-PEDF binding to cell-surface receptors.	A73025	45-72	serpin family F member 1	Homo sapiens	170-174
12123742-0	2002	Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes.	A73025	11-41	interleukin 1 alpha	Bos taurus	126-135
12123742-1	2002	In this study we determined the in vitro effects of polysulfated glycosaminoglycan (PSGAG) and the glucocorticoid triamcinolone acetonid (TA) on the IL-1 altered expression and activity of matrix metalloproteinases (MMP-1, MMP-3), tissue inhibitor of metalloproteinases-1, the plasminogen activators tPA and uPA and plasminogen activator inhibitor 1 by articular chondrocytes.	A73025	52-82	interstitial collagenase	Bos taurus	216-221
12123742-1	2002	In this study we determined the in vitro effects of polysulfated glycosaminoglycan (PSGAG) and the glucocorticoid triamcinolone acetonid (TA) on the IL-1 altered expression and activity of matrix metalloproteinases (MMP-1, MMP-3), tissue inhibitor of metalloproteinases-1, the plasminogen activators tPA and uPA and plasminogen activator inhibitor 1 by articular chondrocytes.	A73025	52-82	stromelysin-1	Bos taurus	223-228
12123742-1	2002	In this study we determined the in vitro effects of polysulfated glycosaminoglycan (PSGAG) and the glucocorticoid triamcinolone acetonid (TA) on the IL-1 altered expression and activity of matrix metalloproteinases (MMP-1, MMP-3), tissue inhibitor of metalloproteinases-1, the plasminogen activators tPA and uPA and plasminogen activator inhibitor 1 by articular chondrocytes.	A73025	52-82	TIMP metallopeptidase inhibitor 1	Bos taurus	231-271
12123742-1	2002	In this study we determined the in vitro effects of polysulfated glycosaminoglycan (PSGAG) and the glucocorticoid triamcinolone acetonid (TA) on the IL-1 altered expression and activity of matrix metalloproteinases (MMP-1, MMP-3), tissue inhibitor of metalloproteinases-1, the plasminogen activators tPA and uPA and plasminogen activator inhibitor 1 by articular chondrocytes.	A73025	52-82	plasminogen activator, tissue type	Bos taurus	300-303
12123742-1	2002	In this study we determined the in vitro effects of polysulfated glycosaminoglycan (PSGAG) and the glucocorticoid triamcinolone acetonid (TA) on the IL-1 altered expression and activity of matrix metalloproteinases (MMP-1, MMP-3), tissue inhibitor of metalloproteinases-1, the plasminogen activators tPA and uPA and plasminogen activator inhibitor 1 by articular chondrocytes.	A73025	52-82	plasminogen activator, urokinase	Bos taurus	308-311
12123742-1	2002	In this study we determined the in vitro effects of polysulfated glycosaminoglycan (PSGAG) and the glucocorticoid triamcinolone acetonid (TA) on the IL-1 altered expression and activity of matrix metalloproteinases (MMP-1, MMP-3), tissue inhibitor of metalloproteinases-1, the plasminogen activators tPA and uPA and plasminogen activator inhibitor 1 by articular chondrocytes.	A73025	52-82	serpin family E member 1	Bos taurus	316-349
9407097-0	1997	Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans.	A73025	72-99	microtubule associated protein tau	Homo sapiens	57-60
2396900-7	1990	Total lipoprotein lipase activity (T-LPL) (LPL + HTGL) of the GAG-PS group at 10 weeks was higher than that of the cholesterol-diet group.	A73025	62-68	lipoprotein lipase	Oryctolagus cuniculus	37-40
1710897-4	1991	Surprisingly a higher amount of product in the elastase containing assays were found in the presence of glycosaminoglycan polysulfate and sodium pentosan polysulfate.	A73025	104-133	elastase, neutrophil expressed	Homo sapiens	47-55
2282507-4	1990	Sulfated glycosaminoglycans as heparan sulfate and heparin extracted the asymmetric AChE from the synaptic basal lamina.	A73025	0-27	acetylcholinesterase	Rattus norvegicus	84-88
2334461-1	1990	The effect of diclofenac-Na, glycosaminoglycanpolysulfate (GAGPS), eglin C and alpha 1-proteinase inhibitor on the activity of elastase from polymorphonuclear granulocytes (PMN-elastase) was tested under various conditions.	A73025	29-57	elastase, neutrophil expressed	Homo sapiens	127-135
2334461-1	1990	The effect of diclofenac-Na, glycosaminoglycanpolysulfate (GAGPS), eglin C and alpha 1-proteinase inhibitor on the activity of elastase from polymorphonuclear granulocytes (PMN-elastase) was tested under various conditions.	A73025	59-64	elastase, neutrophil expressed	Homo sapiens	127-135
2396900-7	1990	Total lipoprotein lipase activity (T-LPL) (LPL + HTGL) of the GAG-PS group at 10 weeks was higher than that of the cholesterol-diet group.	A73025	62-68	lipoprotein lipase	Oryctolagus cuniculus	43-46
7192112-2	1980	The effect of glycosaminoglycan polysulphate (GAGPS) upon the metabolism of proteoglycan (PG) and collagen in chick embryos and human cartilage was studied.	A73025	14-44	versican	Gallus gallus	76-88
2776976-2	1989	TGF-beta 1 and 2 (1-10 ng/ml) elicit a striking increase in the accumulation of Alcian blue, pH 1-positive cartilage matrix, and a corresponding twofold to threefold increase in the accumulation of 35S-sulfate- or 3H-glucosamine-labeled sulfated glycosaminoglycans (GAG) by high density micromass cultures prepared from the cells of whole stage 23/24 limb buds or the homogeneous population of chondrogenic precursor cells comprising the distal subridge mesenchyme of stage 25 wing buds.	A73025	237-264	transforming growth factor beta 1	Gallus gallus	0-16
6268728-5	1981	The monosaccharide composition of these sulfated glycosaminoglycans showed N-acetyl glucosamine (Glu-NAc) as a main monosaccharide, and xylose (Xyl), glucose (Glu), galactose (Gal), hyaluronic acid (Hu-A) as minor monosaccharides.	A73025	40-67	synuclein alpha	Homo sapiens	101-104
34272015-1	2021	Cutaneous dermal mucinoses are a group of conditions characterized by abnormal deposition of mucin (hyaluronic acid and sulfated glycosaminoglycans) in the dermis.	A73025	120-147	LOC100508689	Homo sapiens	93-98
2470746-1	1989	The high heparin affinity subtype C of the secretory enzyme extracellular superoxide dismutase (EC-SOD) exists in the body mainly complexed with extracellular sulfated glycosaminoglycans (SGAGs).	A73025	159-186	superoxide dismutase 3	Homo sapiens	60-94
2470746-1	1989	The high heparin affinity subtype C of the secretory enzyme extracellular superoxide dismutase (EC-SOD) exists in the body mainly complexed with extracellular sulfated glycosaminoglycans (SGAGs).	A73025	159-186	superoxide dismutase 3	Homo sapiens	96-102
2967302-0	1988	Sulfated glycosaminoglycans modify growth factor-induced neurite outgrowth in PC12 cells.	A73025	0-27	myotrophin	Rattus norvegicus	35-48
6217139-2	1982	Glycosaminoglycan polysulfate (GAGPS = Arteparon) is used for the treatment of degenerative joint diseases; it inhibits enzymes that dissociate ground substance, e.g. hyaluronidase, beta-glucuronidase, and acid phosphatase.	A73025	0-29	glucuronidase beta	Homo sapiens	182-200
6210440-5	1982	Interactions between sulfated glycosaminoglycans produced by the fibroblasts and fibronectin could also be demonstrated by affinity chromatography on immobilized plasma fibronectin and by immunoprecipitation of fibronectin in conditioned culture medium, which resulted in a coprecipitation of the sulfated glycosaminoglycans.	A73025	21-48	fibronectin 1	Homo sapiens	81-92
6210440-5	1982	Interactions between sulfated glycosaminoglycans produced by the fibroblasts and fibronectin could also be demonstrated by affinity chromatography on immobilized plasma fibronectin and by immunoprecipitation of fibronectin in conditioned culture medium, which resulted in a coprecipitation of the sulfated glycosaminoglycans.	A73025	21-48	fibronectin 1	Homo sapiens	169-180
6210440-5	1982	Interactions between sulfated glycosaminoglycans produced by the fibroblasts and fibronectin could also be demonstrated by affinity chromatography on immobilized plasma fibronectin and by immunoprecipitation of fibronectin in conditioned culture medium, which resulted in a coprecipitation of the sulfated glycosaminoglycans.	A73025	21-48	fibronectin 1	Homo sapiens	169-180
7192112-2	1980	The effect of glycosaminoglycan polysulphate (GAGPS) upon the metabolism of proteoglycan (PG) and collagen in chick embryos and human cartilage was studied.	A73025	14-44	versican	Gallus gallus	90-92
7192112-2	1980	The effect of glycosaminoglycan polysulphate (GAGPS) upon the metabolism of proteoglycan (PG) and collagen in chick embryos and human cartilage was studied.	A73025	46-51	versican	Gallus gallus	76-88
7192112-2	1980	The effect of glycosaminoglycan polysulphate (GAGPS) upon the metabolism of proteoglycan (PG) and collagen in chick embryos and human cartilage was studied.	A73025	46-51	versican	Gallus gallus	90-92
31749361-7	2019	Moreover, the amounts of hydroxyproline and sulfated glycosaminoglycan (sGAG) as the main components of ECM, which were quantified by colorimetry using various APM concentrations, were found to have a linear relationship with DeltaVout (DeltapHint) of the cultured-chondrocyte-based gate ISFET sensor.	A73025	44-70	alanyl aminopeptidase, membrane	Homo sapiens	160-163
303116-8	1977	Diisopropyl phosphorofluoridate, benzamidine, polyanethol sulfonate and pentosane polysulphate inhibit the activation, which is also sensitive to C1-inactivator and anti-C1r IgC.	A73025	72-94	complement C1r	Homo sapiens	170-173
603757-2	1977	A study has been made of a low molecular weight semi-synthetic heparin analogue, A73025, that may be clinically useful as an antithrombotic agent because of its reported high specificity for antithrombin III.	A73025	81-87	serpin family C member 1	Homo sapiens	191-207
603758-5	1977	Following intravenous injection of twice the quantity of A73025, an equivalent anti-factor Xa activity was obtained, in the agreement with our previous studies.	A73025	57-63	coagulation factor X	Homo sapiens	84-93
603758-6	1977	However, it was found that PRP containing heparin and A73025 with comparable anti-Factor Xa acitvity responded differently to the addition of thrombin, as A73025 barely inhibited thrombin induced aggregation.	A73025	54-60	coagulation factor X	Homo sapiens	82-91
603758-6	1977	However, it was found that PRP containing heparin and A73025 with comparable anti-Factor Xa acitvity responded differently to the addition of thrombin, as A73025 barely inhibited thrombin induced aggregation.	A73025	54-60	coagulation factor II, thrombin	Homo sapiens	142-150
603758-6	1977	However, it was found that PRP containing heparin and A73025 with comparable anti-Factor Xa acitvity responded differently to the addition of thrombin, as A73025 barely inhibited thrombin induced aggregation.	A73025	155-161	complement component 4 binding protein alpha	Homo sapiens	27-30
603758-8	1977	Heparin and A73025 were neutralized to approximately the same degree by a crude PF4 preparation.	A73025	12-18	platelet factor 4	Homo sapiens	80-83
33318190-0	2020	Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates.	A73025	0-27	tumor protein p53	Homo sapiens	59-62
32448126-1	2020	BACKGROUND: Mucopolysaccharidosis type II (MPS II) or Hunter syndrome is an X-linked recessive lysosomal storage disorder resulting from deficient activity of iduronate 2-sulfatase (IDS) and the progressive lysosomal accumulation of sulfated glycosaminoglycans (GAGs).	A73025	233-260	iduronate 2-sulfatase	Homo sapiens	182-185
31749361-7	2019	Moreover, the amounts of hydroxyproline and sulfated glycosaminoglycan (sGAG) as the main components of ECM, which were quantified by colorimetry using various APM concentrations, were found to have a linear relationship with DeltaVout (DeltapHint) of the cultured-chondrocyte-based gate ISFET sensor.	A73025	72-76	alanyl aminopeptidase, membrane	Homo sapiens	160-163
28209294-0	2017	Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-beta-induced cell behaviors of human scar dermal fibroblasts.	A73025	0-27	syntaxin 2	Homo sapiens	81-91
29737046-7	2019	Petaloid RCP significantly increased the weight of the cartilage pellets: The petaloid RCP group weighed 7.7 +- 1.2 mg (n = 108), whereas the control group weighed 5.3 +- 1.6 mg. Sulfated glycosaminoglycan and DNA contents were significantly higher in the petaloid RCP group than in the control group.	A73025	179-205	CGRP receptor component	Homo sapiens	9-12
32254916-3	2019	Chondroitin sulfate (CS), a sulfated glycosaminoglycan (GAG), is distributed throughout animal bodies, including cartilage and the extracellular matrix (ECM), and it has been widely utilized in the dietary supplement and pharmaceutical industries.	A73025	28-54	citrate synthase	Homo sapiens	21-23
28209294-0	2017	Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-beta-induced cell behaviors of human scar dermal fibroblasts.	A73025	0-27	transforming growth factor beta 1	Homo sapiens	115-123