PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2676659-1 1989 Fish oils, containing omega-3 fatty acids (omega 3FAs), favorably influence plasma lipoproteins in nondiabetic humans and prevent the development of insulin resistance induced by fat feeding in rats. Fatty Acids, Omega-3 22-41 insulin Homo sapiens 149-156 2676659-1 1989 Fish oils, containing omega-3 fatty acids (omega 3FAs), favorably influence plasma lipoproteins in nondiabetic humans and prevent the development of insulin resistance induced by fat feeding in rats. Fatty Acids, Omega-3 43-53 insulin Homo sapiens 149-156 2541665-5 1989 Plasma total cholesterol, low-density lipoprotein cholesterol, and serum apolipoprotein B levels rose significantly during the omega-3 fatty acid supplementation period. Fatty Acids, Omega-3 127-145 apolipoprotein B Homo sapiens 73-89 2751481-3 1989 To test the hypothesis that omega-3 fatty acids exert a protective effect in LDL receptor-deficient animals by lowering hyperlipidemia, reducing platelet aggregation, and reducing the severity of atherosclerosis, we evaluated young homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits that were fed omega-3 fatty acids. Fatty Acids, Omega-3 28-47 low-density lipoprotein receptor Oryctolagus cuniculus 77-89 2537393-1 1989 The effects of incorporation of dietary n-3 polyunsaturated fatty acids (PUFA) into rat liver plasma membrane on the activity of 5"-nucleotidase (EC 3.1.3.5) was studied. Fatty Acids, Omega-3 40-71 5' nucleotidase, ecto Rattus norvegicus 129-144 2653924-4 1989 However, enthusiasm for the use of omega-3 fatty acids in diabetes has been dampened by reports of potentially deleterious effects of these agents, including increased plasma glucose, glycosylated hemoglobin, plasma total cholesterol and LDL cholesterol, and serum apolipoprotein B levels. Fatty Acids, Omega-3 35-54 apolipoprotein B Homo sapiens 265-281 2651462-9 1989 It is suggested that the ameliorative effects of N-3 fatty acid dietary supplements in patients with hypersensitive diseases may be, in part, the result of decreased IL-1 production. Fatty Acids, Omega-3 49-63 interleukin 1 alpha Homo sapiens 166-170 2547543-6 1989 FO feeding (in SFO/FO and GLA/FO rats) further reduced the 20:4n-6 level and replaced it by n-3 fatty acids. Fatty Acids, Omega-3 92-107 galactosidase, alpha Rattus norvegicus 26-29 2536273-3 1989 Both cholesterol and saturated fat down-regulate the LDL receptor and inhibit the removal of LDL from the plasma by the liver. Fatty Acids, Omega-3 21-34 low density lipoprotein receptor Homo sapiens 53-65 2536273-4 1989 Saturated fat down-regulates the LDL receptor, especially when cholesterol is concurrently present in the diet. Fatty Acids, Omega-3 0-13 low density lipoprotein receptor Homo sapiens 33-45 2650691-1 1989 The evidence presented here favours the view that dietary supplementation with n-3 fatty acids results in attenuated activity of pro-inflammatory leukotrienes formed through the 5-lipoxygenase pathway in leucocytes. Fatty Acids, Omega-3 79-94 arachidonate 5-lipoxygenase Homo sapiens 178-192 3320694-4 1987 It is hypothesized that dietary enrichment with omega 3 fatty acids increases the incorporation of these fatty acids into the beta cell phospholipid membrane thus enhancing insulin secretion. Fatty Acids, Omega-3 48-67 insulin Homo sapiens 173-180 3342019-0 1988 Delta 6-desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or omega 3 fatty acids. Fatty Acids, Omega-3 99-118 fatty acid desaturase 2 Rattus norvegicus 0-18 2848770-0 1988 In vitro effects of omega-3 fatty acids on neutrophil intracellular calcium homeostasis and receptor expression for FMLP and LTB4. Fatty Acids, Omega-3 20-39 formyl peptide receptor 1 Homo sapiens 116-120 2848770-8 1988 Since omega-3 fatty acids inhibit the expression of receptors for two activators of PMNs, FMLP and LTB4, as well as the [Ca2+]i rise in response to those two stimuli, we propose that the antiinflammatory properties of EPA and DHA may be attributed, at least in part, to alteration in membrane activation of phagocytes. Fatty Acids, Omega-3 6-25 formyl peptide receptor 1 Homo sapiens 90-94 2836574-0 1988 Effect of dietary cholesterol and/or omega 3 fatty acids on lipid composition and delta 5-desaturase activity of rat liver microsomes. Fatty Acids, Omega-3 37-56 fatty acid desaturase 1 Rattus norvegicus 82-100 3320694-7 1987 Augmented insulin secretion and increased insulin sensitivity induced by chronic omega 3 fatty acid ingestion would positively influence carbohydrate metabolism and improve glucose homeostasis. Fatty Acids, Omega-3 81-99 insulin Homo sapiens 10-17 3002485-9 1986 These results suggest that the extensive elongation of eicosapentaenoate by these cells serves to remove n - 3 polyunsaturated fatty acids from the pool of cellular acyl groups which are released in response to thrombin and are thus made available for metabolism by cyclooxygenase and lipoxygenase enzymes. Fatty Acids, Omega-3 105-138 coagulation factor II, thrombin Homo sapiens 211-219 3038454-7 1987 We conclude that in NIDDs dietary supplementation of omega 3 fatty acids improves in vivo insulin sensitivity and lowers plasma triglyceride levels, while erythrocyte membrane fluidity remains unaltered. Fatty Acids, Omega-3 53-72 insulin Homo sapiens 90-97 3498153-8 1987 The differences in these enzymatic responses suggest that certain form(s) of cytochrome P-450 are preferentially increased by feeding the omega-3 fatty acids of menhaden oil. Fatty Acids, Omega-3 138-157 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 77-93 3037555-10 1987 The administration of n-3 fatty acids also reduced the ratio of 20:4n-6 to 20:3n-6 in GLA + FO-treated rats indicating that n-3 fatty acids inhibited the activity of delta-5-desaturase. Fatty Acids, Omega-3 22-37 fatty acid desaturase 1 Rattus norvegicus 166-184 3037555-10 1987 The administration of n-3 fatty acids also reduced the ratio of 20:4n-6 to 20:3n-6 in GLA + FO-treated rats indicating that n-3 fatty acids inhibited the activity of delta-5-desaturase. Fatty Acids, Omega-3 124-139 fatty acid desaturase 1 Rattus norvegicus 166-184 3559400-0 1987 Effect of dietary n-3 fatty acids on HMG-CoA reductase and ACAT activities in liver and intestine of the rabbit. Fatty Acids, Omega-3 18-33 sterol O-acyltransferase 1 Oryctolagus cuniculus 59-63 3321086-0 1986 Regulation of 5-lipoxygenase pathway product generation in human neutrophils by n-3 fatty acids. Fatty Acids, Omega-3 80-95 arachidonate 5-lipoxygenase Homo sapiens 14-28 21344281-0 1984 Effects of a (n-3) polyunsaturated fatty acid-deficient diet on profiles of serum vitellogenin and lipoprotein in vitellogenic trout (Salmo gairdneri). Fatty Acids, Omega-3 13-45 LOC100136735 Oncorhynchus mykiss 82-94 33705952-9 2021 In conclusion, a postweaning n-3 PUFA diet enhanced Nrg4 expression in adipose tissues, associated with attenuation of NAFLD induced by SL rearing. Fatty Acids, Omega-3 29-37 neuregulin 4 Homo sapiens 52-56 33705952-11 2021 Thus, white adipose tissue browning induced by n-3 PUFAs may promote NRG4 production through the PPARG pathway. Fatty Acids, Omega-3 47-56 neuregulin 4 Homo sapiens 69-73 33705952-11 2021 Thus, white adipose tissue browning induced by n-3 PUFAs may promote NRG4 production through the PPARG pathway. Fatty Acids, Omega-3 47-56 peroxisome proliferator-activated receptor gamma Rattus norvegicus 97-102 33864951-5 2021 N-3 polyunsaturated fatty acids (n-3 PUFA) have been of interest due to their anti-inflammatory actions and shown to have beneficial effects in obesity-related diseases. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 37-41 33665922-0 2021 Fat-1 transgenic mice rich in endogenous omega-3 fatty acids are protected from lipopolysaccharide-induced cardiac dysfunction. Fatty Acids, Omega-3 41-60 FAT atypical cadherin 1 Mus musculus 0-5 33665922-3 2021 In the present study, we investigated whether the constantly elevated levels of endogenous omega-3 PUFA in transgenic fat-1 mice would alleviate the lipopolysaccharide (LPS)-induced cardiac failure and death. Fatty Acids, Omega-3 91-103 FAT atypical cadherin 1 Mus musculus 118-123 34018532-3 2021 We have previously shown that FABP7"s effects on cell migration can be reversed when GBM cells are cultured in medium supplemented with the omega-3 fatty acid, docosahexaenoic acid (DHA). Fatty Acids, Omega-3 140-158 fatty acid binding protein 7 Homo sapiens 30-35 34049426-7 2021 Moreover, omega 3 fatty acids inhabited the expressions of inflammatory cells (CD4, CD8 and CD11b) and suppressed the level of NF-kappaB. Fatty Acids, Omega-3 10-29 Cd4 molecule Rattus norvegicus 79-82 34049426-7 2021 Moreover, omega 3 fatty acids inhabited the expressions of inflammatory cells (CD4, CD8 and CD11b) and suppressed the level of NF-kappaB. Fatty Acids, Omega-3 10-29 integrin subunit alpha M Rattus norvegicus 92-97 34052364-0 2021 Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice. Fatty Acids, Omega-3 11-20 FAT atypical cadherin 1 Mus musculus 105-110 34052364-8 2021 These OB-induced changes were markedly attenuated by endogenous n-3 PUFAs in Fat-1 mice. Fatty Acids, Omega-3 64-73 FAT atypical cadherin 1 Mus musculus 77-82 34052364-11 2021 In conclusion, endogenous n-3 PUFAs in Fat-1 mice attenuated abnormal behavior in the depression model through restoration of lipid metabolism and suppression of inflammatory response. Fatty Acids, Omega-3 26-35 FAT atypical cadherin 1 Mus musculus 39-44 33991364-2 2021 A recent randomized clinical trial demonstrated that daily supplementation with high-dose marine omega-3 FAs lowered plasma triglyceride and C-reactive protein levels (1). Fatty Acids, Omega-3 97-108 C-reactive protein Homo sapiens 141-159 33998914-7 2021 This meta-analysis indicates that supplementing participants with omega-3 fatty acids more than 2000 mg daily and more than 10 weeks resulted in a significant and more favorable improvement in plasma adiponectin levels. Fatty Acids, Omega-3 66-85 adiponectin, C1Q and collagen domain containing Homo sapiens 200-211 33998914-9 2021 CONCLUSION: The evidence supports a beneficial effect of omega-3 FAs intake on serum adiponectin levels but does not appear to impact on leptin concentrations. Fatty Acids, Omega-3 57-68 adiponectin, C1Q and collagen domain containing Homo sapiens 85-96 33998914-10 2021 Larger well-designed RCTs are still required to evaluate the effect of omega-3 FAs on leptin in specific diseases. Fatty Acids, Omega-3 71-82 leptin Homo sapiens 86-92 33306506-10 2021 By using an additive model of inheritance, our moderation analysis showed that PNPLA3 rs738409 significantly modulates the relationship between carbohydrate (%), n-3 PUFAs, total isoflavones, methionine, and choline intakes and fibrosis severity in a dose-dependent, genotype manner. Fatty Acids, Omega-3 162-171 patatin like phospholipase domain containing 3 Homo sapiens 79-85 33982073-0 2021 Dietary SFAs and omega-6 Fatty Acids Alter Incorporation of omega-3 Fatty Acids into Milk Fat of Lactating CD-1 Mice and Tissues of Offspring. Fatty Acids, Omega-3 60-79 CD1 antigen complex Mus musculus 107-111 33991364-4 2021 Previous reports indicate increased systemic exposures of cyclosporine and sirolimus in patients receiving high-dose marine omega-3 FA supplements (3, 4) which could be related to reduced drug metabolism supported by the in vitro experimental observation of an inhibitory effect of omega-3 FAs on cytochrome P450 (CYP) 3A enzymes (5) expressed in the intestine and liver. Fatty Acids, Omega-3 124-134 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 297-321 33991364-4 2021 Previous reports indicate increased systemic exposures of cyclosporine and sirolimus in patients receiving high-dose marine omega-3 FA supplements (3, 4) which could be related to reduced drug metabolism supported by the in vitro experimental observation of an inhibitory effect of omega-3 FAs on cytochrome P450 (CYP) 3A enzymes (5) expressed in the intestine and liver. Fatty Acids, Omega-3 282-293 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 297-321 33964966-0 2021 The effect of omega3 fatty acid supplementation on PPARgamma and UCP2 expressions, resting energy expenditure, and appetite in athletes. Fatty Acids, Omega-3 14-31 peroxisome proliferator activated receptor gamma Homo sapiens 51-60 33964966-0 2021 The effect of omega3 fatty acid supplementation on PPARgamma and UCP2 expressions, resting energy expenditure, and appetite in athletes. Fatty Acids, Omega-3 14-31 uncoupling protein 2 Homo sapiens 65-69 33744039-6 2021 Beta coefficients for annual eGFR change in relation to plasma linoleic acid (LA; 50.1% of total FAs in CE), omega-3 FAs (EPA + DHA; 1.7%), odd-chain FAs (C15:0 and C17:0; 0.2%), and C14:0 (0.7%) were obtained from linear regression analyses adjusted for age, sex, smoking, and alcohol intake. Fatty Acids, Omega-3 109-120 epidermal growth factor receptor Homo sapiens 29-33 33917814-2 2021 Here, mechanisms through which lifelong exposure to n-3 PUFA-enriched or n-6/n-3 balanced diets could elicit a protective role in a rat model of Abeta-induced toxicity were investigated. Fatty Acids, Omega-3 52-60 amyloid beta precursor protein Rattus norvegicus 145-150 33749495-8 2021 Long-chain omega-3 fatty acids, the soy isoflavone genistein, the AMPK activator berberine, glucosamine, and ketone bodies can down-regulate NF-kappaB activation. Fatty Acids, Omega-3 11-30 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 66-70 33749495-8 2021 Long-chain omega-3 fatty acids, the soy isoflavone genistein, the AMPK activator berberine, glucosamine, and ketone bodies can down-regulate NF-kappaB activation. Fatty Acids, Omega-3 11-30 nuclear factor kappa B subunit 1 Homo sapiens 141-150 33735708-9 2021 Besides, omega-3 reduced the expression of iNOS and Keap1 and increased the activity/concentration of HO1, NQO1 and GPX. Fatty Acids, Omega-3 9-16 nitric oxide synthase 2 Rattus norvegicus 43-47 33735708-9 2021 Besides, omega-3 reduced the expression of iNOS and Keap1 and increased the activity/concentration of HO1, NQO1 and GPX. Fatty Acids, Omega-3 9-16 Kelch-like ECH-associated protein 1 Rattus norvegicus 52-57 33735708-9 2021 Besides, omega-3 reduced the expression of iNOS and Keap1 and increased the activity/concentration of HO1, NQO1 and GPX. Fatty Acids, Omega-3 9-16 heme oxygenase 1 Rattus norvegicus 102-105 33735708-9 2021 Besides, omega-3 reduced the expression of iNOS and Keap1 and increased the activity/concentration of HO1, NQO1 and GPX. Fatty Acids, Omega-3 9-16 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 107-111 32716569-12 2021 Serum amyloid-A1 significantly reduced (P < .001) as a potential biomarker of efficacy for omega-3FA. Fatty Acids, Omega-3 91-100 serum amyloid A1 Homo sapiens 0-16 33190574-0 2021 Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation for prevention and treatment of perinatal depression: a systematic review and meta-analysis of randomized-controlled trials. Fatty Acids, Omega-3 0-34 pumilio RNA binding family member 3 Homo sapiens 40-44 33922600-2 2021 Seafood has long been considered a very valuable dietary component, mainly due to presence of n-3 polyunsaturated fatty acids (n-3 PUFA) but it is also an important source of protein (including collagen), anserine, taurine, iodine, selenium, vitamin A, vitamin K, vitamin D, tocopherols, B vitamins and astaxanthin. Fatty Acids, Omega-3 94-125 pumilio RNA binding family member 3 Homo sapiens 131-135 33840312-6 2022 The MCAP Score was correlated with serum carotenoids and serum omega-3 fatty acids, and improvements in the score were associated with weight loss over six months of study. Fatty Acids, Omega-3 63-82 bromodomain containing 4 Homo sapiens 4-8 33917814-9 2021 N-3 PUFA enriched diet further increased interleukin-10 and 8-hydroxy-2"-deoxyguanosine levels. Fatty Acids, Omega-3 0-8 interleukin 10 Rattus norvegicus 41-55 33917814-10 2021 In conclusion, our data highlight the possible neuroprotective role of n-3 PUFA in perturbation of oxidative equilibrium induced by Abeta-administration. Fatty Acids, Omega-3 71-79 amyloid beta precursor protein Rattus norvegicus 132-137 33710695-0 2021 Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid. Fatty Acids, Omega-3 0-19 arachidonate 15-lipoxygenase Mus musculus 48-54 33605486-0 2021 Endogenous production of n-3 PUFAs protects mice from CCl4 -induced liver fibrosis by regulating mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 25-34 chemokine (C-C motif) ligand 4 Mus musculus 54-58 33605486-0 2021 Endogenous production of n-3 PUFAs protects mice from CCl4 -induced liver fibrosis by regulating mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 25-34 mechanistic target of rapamycin kinase Mus musculus 97-101 33605486-0 2021 Endogenous production of n-3 PUFAs protects mice from CCl4 -induced liver fibrosis by regulating mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 25-34 B cell leukemia/lymphoma 2 Mus musculus 106-111 33605486-0 2021 Endogenous production of n-3 PUFAs protects mice from CCl4 -induced liver fibrosis by regulating mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 25-34 BCL2-associated X protein Mus musculus 112-115 33605486-4 2021 We demonstrated that n-3 PUFAs elevation strongly prevented CCl4 -induced hepatic damage and inhibited the activation of hepatic stellate cells. Fatty Acids, Omega-3 21-30 chemokine (C-C motif) ligand 4 Mus musculus 60-64 33605486-15 2021 The direct effect of DHA on primary hepatic stellate cells (HSCs) were also investigated in a co-culture experiment.N-3 PUFAs as a result of mfat-1 activity rendered a strong protective effect on liver fibrosis. Fatty Acids, Omega-3 116-125 M-line adipose tissue, general adiposity 1 Mus musculus 141-147 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 M-line adipose tissue, general adiposity 1 Mus musculus 10-16 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 mechanistic target of rapamycin kinase Mus musculus 96-100 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 B cell leukemia/lymphoma 2 Mus musculus 105-110 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 BCL2-associated X protein Mus musculus 111-114 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 chemokine (C-C motif) ligand 4 Mus musculus 213-217 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 mechanistic target of rapamycin kinase Mus musculus 325-329 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 B cell leukemia/lymphoma 2 Mus musculus 334-339 33605486-19 2021 Moreover, mfat-1 transgenic mice showed significant reduction of proteins which are involved in mTOR and Bcl-2/Bax signaling pathways.Collectively, these results suggest that n-3 PUFAs elevation strongly prevents CCl4 -induced hepatic damage by directly inhibiting the activation of HSCs and regulating the basal activity of mTOR and Bcl-2/Bax signaling pathways. Fatty Acids, Omega-3 175-184 BCL2-associated X protein Mus musculus 340-343 33710695-7 2021 Alox15 deficiency suppressed the formation of n-3 PUFA-derived 15-hydroxy eicosapentaenoic acid (15-HEPE). Fatty Acids, Omega-3 46-54 arachidonate 15-lipoxygenase Mus musculus 0-6 33170092-11 2021 Thus, it might be assumed that the protective role of omega-3 fatty acids might be mediated by adiponectin in patients with metabolic syndrome. Fatty Acids, Omega-3 54-73 adiponectin, C1Q and collagen domain containing Homo sapiens 95-106 33749892-0 2021 omega3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor alpha. Fatty Acids, Omega-3 0-17 C-X-C motif chemokine ligand 1 Homo sapiens 120-125 33749892-0 2021 omega3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor alpha. Fatty Acids, Omega-3 0-17 C-X-C motif chemokine ligand 2 Homo sapiens 130-135 33749892-0 2021 omega3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor alpha. Fatty Acids, Omega-3 0-17 retinoid X receptor alpha Homo sapiens 173-198 33502893-1 2021 Evidence suggests that n-3 polyunsaturated fatty acids (PUFA) may act as activators of the Nrf2 antioxidant pathway. Fatty Acids, Omega-3 23-54 nuclear factor, erythroid derived 2, like 2 Mus musculus 91-95 33630674-5 2021 Omega-3 fatty acids may mitigate the effects of disuse on IR by preventing a decline in insulin signaling proteins. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 88-95 33792795-3 2021 The objectives of this study were to determine the effectiveness of betaactin-D5D for improving n-3 fatty acid production in F1 transgenic channel catfish, as well as examine pleiotropic effects on growth, proximate analysis, disease resistance, and other performance traits. Fatty Acids, Omega-3 96-110 LOC100304816 Ictalurus punctatus 68-77 33714197-0 2021 Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids facilitates the repair of cardiotoxin-induced skeletal muscle injury in fat-1 mice. Fatty Acids, Omega-3 32-63 FAT atypical cadherin 1 Mus musculus 136-141 32799935-11 2021 The data suggest that supplementation of omega-3 fatty acids could reduce the inflammatory state in women with PCOS, through a decrease in hs-CRP and an increase in adiponectin levels. Fatty Acids, Omega-3 41-60 C-reactive protein Homo sapiens 142-145 32799935-11 2021 The data suggest that supplementation of omega-3 fatty acids could reduce the inflammatory state in women with PCOS, through a decrease in hs-CRP and an increase in adiponectin levels. Fatty Acids, Omega-3 41-60 adiponectin, C1Q and collagen domain containing Homo sapiens 165-176 33714197-2 2021 Transgenic fat-1 mice expressing the Caenorhabditis elegans fat-1 gene, encoding n-3 fatty acid desaturase, showed higher n-3 PUFA levels and lower n-6/n-3 PUFA ratios in gastrocnemius muscle tissues. Fatty Acids, Omega-3 81-95 FAT atypical cadherin 1 Mus musculus 11-16 33714197-2 2021 Transgenic fat-1 mice expressing the Caenorhabditis elegans fat-1 gene, encoding n-3 fatty acid desaturase, showed higher n-3 PUFA levels and lower n-6/n-3 PUFA ratios in gastrocnemius muscle tissues. Fatty Acids, Omega-3 81-95 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 60-65 33714197-7 2021 These findings demonstrate that higher endogenous n-3 PUFA levels in fat-1 mice enhances skeletal muscle repair and regeneration following cardiotoxin-induced injury. Fatty Acids, Omega-3 50-58 FAT atypical cadherin 1 Mus musculus 69-74 33580472-0 2021 Altered IFN-gamma Levels after Treatment of Epileptic Patients with Omega-3 Fatty Acids. Fatty Acids, Omega-3 68-87 interferon gamma Homo sapiens 8-17 33411639-0 2021 Omega-3 Fatty Acid Modulation of Serum and Osteocyte Tumor Necrosis Factor Alpha in Adult Mice Exposed to Ionizing Radiation. Fatty Acids, Omega-3 0-18 tumor necrosis factor Mus musculus 53-80 33031856-6 2021 Accumulating literature has demonstrated the beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFA) toward the cardiovascular system, which include ameliorating uncontrolled inflammatory reactions, reduced oxidative stress and mitigating coagulopathy. Fatty Acids, Omega-3 67-98 pumilio RNA binding family member 3 Homo sapiens 104-108 33284965-11 2021 Accordingly, muscle anabolism (mTORC1) and plasma CRP remained unchanged by RE and omega-3, whereas serum IL-6 tended to decrease in omega-3 (pinteraction=0.07). Fatty Acids, Omega-3 133-140 interleukin 6 Homo sapiens 106-110 33567784-7 2021 Free PUFA, mainly n-3 fatty acids (p = 0.0009), were also higher in the meat of pigs fed the high-dose mixture compared with the others. Fatty Acids, Omega-3 18-33 Polyunsaturated fatty acid percentage Sus scrofa 5-9 32853678-11 2021 SiRNA-mediated knock-down of LOX-1 inhibited palmitate-induced ER stress, whereas overexpression of LOX-1 dramatically induced ER stress in L02 cells.LOX-1 is may critical for HFD-induced ER stress, and inhibition of its expression under the treatment of n-3 PUFAs could ameliorate HFD-induced NAFLD. Fatty Acids, Omega-3 255-264 oxidized low density lipoprotein receptor 1 Homo sapiens 100-105 32948825-3 2021 As G protein-coupled receptor 120 (GPR120) was firstly identified as the receptor of omega3FAs, we here investigated the function of GPR120 in DN. Fatty Acids, Omega-3 85-94 free fatty acid receptor 4 Mus musculus 3-33 32948825-3 2021 As G protein-coupled receptor 120 (GPR120) was firstly identified as the receptor of omega3FAs, we here investigated the function of GPR120 in DN. Fatty Acids, Omega-3 85-94 free fatty acid receptor 4 Mus musculus 35-41 33245969-14 2021 CONCLUSIONS: omega-3 PUFAs supplementation influence the systemic effects caused by AP, decreasing the number of leukocytes, lymphocytes, and IL-6 in rat"s blood. Fatty Acids, Omega-3 13-26 interleukin 6 Rattus norvegicus 142-146 33487255-1 2021 BACKGROUND & AIMS: Docohexanoic acid (DHA), a dietary n-3 polyunsaturated fatty-acid omega-3 (n-3, PUFA), showed potential beneficial effects in reducing all-cause mortality in hemodialysis (HD) patients. Fatty Acids, Omega-3 85-92 pumilio RNA binding family member 3 Homo sapiens 99-103 32853678-11 2021 SiRNA-mediated knock-down of LOX-1 inhibited palmitate-induced ER stress, whereas overexpression of LOX-1 dramatically induced ER stress in L02 cells.LOX-1 is may critical for HFD-induced ER stress, and inhibition of its expression under the treatment of n-3 PUFAs could ameliorate HFD-induced NAFLD. Fatty Acids, Omega-3 255-264 oxidized low density lipoprotein receptor 1 Homo sapiens 100-105 33221631-1 2021 We examined the impact of treatment with fish oil (FO), a rich source of omega-3 polyunsaturated fatty acids (n-3 PUFA), on white matter in 37 recent-onset psychosis patients receiving risperidone in a double-blind placebo-controlled randomized clinical trial. Fatty Acids, Omega-3 73-108 pumilio RNA binding family member 3 Homo sapiens 114-118 33295913-0 2021 High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 mice via pre-adipocyte NLRP3 inflammasome inhibition. Fatty Acids, Omega-3 5-20 FAT atypical cadherin 1 Mus musculus 76-81 33446880-7 2021 Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = - 0.168) and interleukin-6 concentrations (r = - 0.115). Fatty Acids, Omega-3 20-51 interleukin 6 Homo sapiens 110-123 33530576-1 2021 BACKGROUND: The association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and prostate cancer (PC) remains unclear. Fatty Acids, Omega-3 47-82 pumilio RNA binding family member 3 Homo sapiens 88-92 33499257-11 2021 In conclusion, high educational levels, older age, fish, seafood consumption, and/or non-smoking, are factors that influence better omega-3 polyunsaturated fatty acid (n-3 PUFA) profile in both trimesters of pregnancy. Fatty Acids, Omega-3 132-166 pumilio RNA binding family member 3 Homo sapiens 172-176 33450081-13 2021 Omega-3 FAs also suppressed C-reactive protein levels and neutrophil-to-lymphocyte ratio in Gr. Fatty Acids, Omega-3 0-11 C-reactive protein Homo sapiens 28-46 33450081-16 2021 Omega-3 FAs significantly increased the expression of TLR2 and TLR4 on both CD14+ and CD16+ monocytes, and TLR4, on macrophages and neutrophils. Fatty Acids, Omega-3 0-11 toll like receptor 2 Homo sapiens 54-58 33450081-16 2021 Omega-3 FAs significantly increased the expression of TLR2 and TLR4 on both CD14+ and CD16+ monocytes, and TLR4, on macrophages and neutrophils. Fatty Acids, Omega-3 0-11 toll like receptor 4 Homo sapiens 63-67 33450081-16 2021 Omega-3 FAs significantly increased the expression of TLR2 and TLR4 on both CD14+ and CD16+ monocytes, and TLR4, on macrophages and neutrophils. Fatty Acids, Omega-3 0-11 CD14 molecule Homo sapiens 76-80 33450081-16 2021 Omega-3 FAs significantly increased the expression of TLR2 and TLR4 on both CD14+ and CD16+ monocytes, and TLR4, on macrophages and neutrophils. Fatty Acids, Omega-3 0-11 Fc gamma receptor IIIa Homo sapiens 86-90 33450081-16 2021 Omega-3 FAs significantly increased the expression of TLR2 and TLR4 on both CD14+ and CD16+ monocytes, and TLR4, on macrophages and neutrophils. Fatty Acids, Omega-3 0-11 toll like receptor 4 Homo sapiens 107-111 33295913-0 2021 High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 mice via pre-adipocyte NLRP3 inflammasome inhibition. Fatty Acids, Omega-3 5-20 NLR family, pyrin domain containing 3 Mus musculus 105-110 33295913-3 2021 Endogenous n-3 PUFAs in fat-1 mice were found to impair hyperglycemia or high glucose level-induced nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome activation and inhibit IL-1beta secretion in adipose tissues. Fatty Acids, Omega-3 11-20 FAT atypical cadherin 1 Mus musculus 24-29 33295913-3 2021 Endogenous n-3 PUFAs in fat-1 mice were found to impair hyperglycemia or high glucose level-induced nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome activation and inhibit IL-1beta secretion in adipose tissues. Fatty Acids, Omega-3 11-20 NLR family, pyrin domain containing 3 Mus musculus 166-171 33295913-3 2021 Endogenous n-3 PUFAs in fat-1 mice were found to impair hyperglycemia or high glucose level-induced nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome activation and inhibit IL-1beta secretion in adipose tissues. Fatty Acids, Omega-3 11-20 interleukin 1 alpha Mus musculus 209-217 33295913-4 2021 In addition, endogenous n-3 PUFAs also inhibited high glucose-induced caspase-1 activity and IL-1beta secretion in pre-adipocyte-enriched stromal vascular fractions (SVF) isolated from adipose tissues. Fatty Acids, Omega-3 24-33 caspase 1 Mus musculus 70-79 33295913-4 2021 In addition, endogenous n-3 PUFAs also inhibited high glucose-induced caspase-1 activity and IL-1beta secretion in pre-adipocyte-enriched stromal vascular fractions (SVF) isolated from adipose tissues. Fatty Acids, Omega-3 24-33 interleukin 1 alpha Mus musculus 93-101 32727335-3 2021 n-3 fatty acids and curcumin revealed neuro-modulatory and anti-inflammatory effects through several pathways, of which the suppression of IL-1beta gene expression is an important inflammatory pathway. Fatty Acids, Omega-3 0-15 interleukin 1 alpha Homo sapiens 139-147 32727335-4 2021 The aim of this study was the investigation of synergistic relation of n -3 fatty acids and nano-curcumin on IL-1beta gene expression and serum levels in migraine patients. Fatty Acids, Omega-3 71-87 interleukin 1 alpha Homo sapiens 109-117 33342151-10 2020 Interventions studies on n-3 polyunsaturated fatty acid (n-3 PUFA), zinc and vitamin A confirmed the positive effects of such nutrients on immunity and disease outcome. Fatty Acids, Omega-3 25-55 pumilio RNA binding family member 3 Homo sapiens 61-65 33536711-1 2021 The fact that Fat-1 transgenic mice producing n-3 polyunsaturated fatty acids via overexpressed 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric tumorigenesis through rejuvenation of chronic atrophic gastritis (CAG) led us to study whether dietary intake of walnut plentiful of n-3 PUFAs can be nutritional intervention to prevent H. pylori-associated gastric cancer. Fatty Acids, Omega-3 46-77 FAT atypical cadherin 1 Mus musculus 14-19 33536711-1 2021 The fact that Fat-1 transgenic mice producing n-3 polyunsaturated fatty acids via overexpressed 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric tumorigenesis through rejuvenation of chronic atrophic gastritis (CAG) led us to study whether dietary intake of walnut plentiful of n-3 PUFAs can be nutritional intervention to prevent H. pylori-associated gastric cancer. Fatty Acids, Omega-3 317-326 FAT atypical cadherin 1 Mus musculus 14-19 33482602-0 2021 Systematic review of marine-derived omega-3 fatty acid supplementation effects on leptin, adiponectin, and the leptin-to-adiponectin ratio. Fatty Acids, Omega-3 36-54 leptin Homo sapiens 82-88 33482602-0 2021 Systematic review of marine-derived omega-3 fatty acid supplementation effects on leptin, adiponectin, and the leptin-to-adiponectin ratio. Fatty Acids, Omega-3 36-54 adiponectin, C1Q and collagen domain containing Homo sapiens 90-101 33482602-0 2021 Systematic review of marine-derived omega-3 fatty acid supplementation effects on leptin, adiponectin, and the leptin-to-adiponectin ratio. Fatty Acids, Omega-3 36-54 leptin Homo sapiens 111-117 33482602-0 2021 Systematic review of marine-derived omega-3 fatty acid supplementation effects on leptin, adiponectin, and the leptin-to-adiponectin ratio. Fatty Acids, Omega-3 36-54 adiponectin, C1Q and collagen domain containing Homo sapiens 121-132 33482602-3 2021 While some studies have shown that marine-derived omega-3 fatty acids (eicosapentaenoic acid [EPA] and/or docosahexaenoic acid [DHA]) have effects on leptin and adiponectin in the context of inflammation, the extent of their effects remain unclear. Fatty Acids, Omega-3 50-69 leptin Homo sapiens 150-156 33482602-3 2021 While some studies have shown that marine-derived omega-3 fatty acids (eicosapentaenoic acid [EPA] and/or docosahexaenoic acid [DHA]) have effects on leptin and adiponectin in the context of inflammation, the extent of their effects remain unclear. Fatty Acids, Omega-3 50-69 adiponectin, C1Q and collagen domain containing Homo sapiens 161-172 32615378-3 2020 Oil recovery yield using the adjusted pH-shift process was lower than with classic heat-induced oil isolation (90 C/20 min), but pH-shift-produced oils had higher amounts of n-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 175-206 pumilio RNA binding family member 3 Homo sapiens 212-216 32886112-1 2020 BACKGROUND: Supplementing animal diets with fish oil increases myocardial omega-3 polyunsaturated fatty acids [omega-3 (n-3) PUFA], lowers heart rate, and prevents malignant cardiac arrhythmias. Fatty Acids, Omega-3 74-109 pumilio RNA binding family member 3 Homo sapiens 125-129 33428138-0 2020 Combined Effects of Plant Sterols with Low Ratio of n-6/n-3 Polyunsaturated Fatty Acids against Atherosclerosis in ApoE-/- Mice. Fatty Acids, Omega-3 56-87 apolipoprotein E Mus musculus 115-119 33180794-0 2020 Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy. Fatty Acids, Omega-3 0-19 NADPH oxidase 4 Rattus norvegicus 133-137 32632845-5 2020 Moreover, we identified 5-hydroxyeicosapentaenoic acid (5-HEPE), an omega-3 fatty acid metabolite, to be increased in Ames dwarf brown adipose tissue (BAT), as well as in circulation. Fatty Acids, Omega-3 68-86 paired like homeodomain factor 1 Mus musculus 118-128 33247230-1 2020 Supplementation of cattle diets with n-3-polyunsaturated fatty acids (PUFA) can improve reproductive efficiency. Fatty Acids, Omega-3 37-68 PUFA Bos taurus 70-74 33078809-0 2020 Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice. Fatty Acids, Omega-3 8-22 glucagon Mus musculus 85-90 33078809-6 2020 While the stimulatory effects of n-3 PUFA on GLP-1 levels could not be attributed to changes in intestinal or plasma dipeptidyl peptidase-4 activity, their beneficial effects on glucose tolerance were abolished when mice were pretreated with the GLP-1 receptor antagonist exendin 9-39. Fatty Acids, Omega-3 33-41 glucagon Mus musculus 45-50 33078809-6 2020 While the stimulatory effects of n-3 PUFA on GLP-1 levels could not be attributed to changes in intestinal or plasma dipeptidyl peptidase-4 activity, their beneficial effects on glucose tolerance were abolished when mice were pretreated with the GLP-1 receptor antagonist exendin 9-39. Fatty Acids, Omega-3 33-41 glucagon-like peptide 1 receptor Mus musculus 246-260 33202985-2 2020 We have previously showed that endogenous n-3 PUFAs contribute to skeletal development and bone quality in fat-1 mice. Fatty Acids, Omega-3 42-51 FAT atypical cadherin 1 Mus musculus 107-112 33227647-1 2020 BACKGROUND: Previous studies have suggested that omega-3 polyunsaturated fatty acids (n-3 PUFA) can favorably influence cardiac autonomic tone. Fatty Acids, Omega-3 49-84 pumilio RNA binding family member 3 Homo sapiens 90-94 33330598-0 2020 Disrupted Lipid Raft Shuttling of FcepsilonRI by n-3 Polyunsaturated Fatty Acid Is Associated With Ligation of G Protein-Coupled Receptor 120 (GPR120) in Human Mast Cell Line LAD2. Fatty Acids, Omega-3 49-79 free fatty acid receptor 4 Homo sapiens 111-141 33330598-0 2020 Disrupted Lipid Raft Shuttling of FcepsilonRI by n-3 Polyunsaturated Fatty Acid Is Associated With Ligation of G Protein-Coupled Receptor 120 (GPR120) in Human Mast Cell Line LAD2. Fatty Acids, Omega-3 49-79 free fatty acid receptor 4 Homo sapiens 143-149 33304901-5 2020 Recent findings point to the beneficial effects of omega-3 fatty acids in cardiac valves, being inversely associated with aortic valve calcification and contributing to the resolution of valvular inflammation by means of the pro-resolving mediator resolvin E1 and downstream signaling through its receptor ChemR23. Fatty Acids, Omega-3 51-70 chemerin chemokine-like receptor 1 Homo sapiens 306-313 32365195-9 2020 The restoration of FADS2 expression, which allows for the endogenous conversion of n-3 fatty acids into proresolving lipid mediators, resulted in a significant reduction in proinflammatory macrophage infiltration and attenuated expression of inflammatory cytokines or adipokines. Fatty Acids, Omega-3 83-98 fatty acid desaturase 2 Homo sapiens 19-24 33158207-6 2020 Oxidized omega-3 fatty acids react with Keap1 to induce Nrf2-regulated gene expression. Fatty Acids, Omega-3 9-28 Kelch-like ECH-associated protein 1 Rattus norvegicus 40-45 33158207-6 2020 Oxidized omega-3 fatty acids react with Keap1 to induce Nrf2-regulated gene expression. Fatty Acids, Omega-3 9-28 NFE2 like bZIP transcription factor 2 Rattus norvegicus 56-60 33081175-10 2020 Supplementing n-3 fatty acids, probiotics, synbiotics, and trace elements increased antioxidant enzymes and reduced hs-CRP and MDA. Fatty Acids, Omega-3 14-29 C-reactive protein Homo sapiens 119-122 32745880-10 2020 The results suggest that n-3 PUFAs possess the most potent protective effects against TGFbeta1-induced profibrogenic gene expression, which is, at least in part, PPARgamma-dependent in HSCs. Fatty Acids, Omega-3 25-34 transforming growth factor, beta 1 Mus musculus 86-94 32745880-10 2020 The results suggest that n-3 PUFAs possess the most potent protective effects against TGFbeta1-induced profibrogenic gene expression, which is, at least in part, PPARgamma-dependent in HSCs. Fatty Acids, Omega-3 25-34 peroxisome proliferator activated receptor gamma Homo sapiens 162-171 33021612-0 2020 n-3 polyunsaturated fatty acids regulate chemerin in cultured adipocytes: role of GPR120 and derived lipid mediators. Fatty Acids, Omega-3 0-31 retinoic acid receptor responder 2 Homo sapiens 41-49 33021612-2 2020 The aim of this study was to investigate the effects of omega-3 polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acids (EPA and DHA), on basal and tumor necrosis factor-alpha (TNF-alpha)-induced chemerin production in 3T3-L1 and human subcutaneous cultured adipocytes. Fatty Acids, Omega-3 56-91 tumor necrosis factor Homo sapiens 164-191 33021612-2 2020 The aim of this study was to investigate the effects of omega-3 polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acids (EPA and DHA), on basal and tumor necrosis factor-alpha (TNF-alpha)-induced chemerin production in 3T3-L1 and human subcutaneous cultured adipocytes. Fatty Acids, Omega-3 56-91 tumor necrosis factor Homo sapiens 193-202 33021612-2 2020 The aim of this study was to investigate the effects of omega-3 polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acids (EPA and DHA), on basal and tumor necrosis factor-alpha (TNF-alpha)-induced chemerin production in 3T3-L1 and human subcutaneous cultured adipocytes. Fatty Acids, Omega-3 56-91 retinoic acid receptor responder 2 Homo sapiens 212-220 33108021-7 2022 Interestingly, activation of PPARgamma and PPARalpha with selective agonists has been shown to decrease mesocorticolimbic DA activity and block neuropsychiatric symptoms similar to CBD and omega-3s, raising the possibility that CBD and omega-3s produce their effects through PPAR signaling. Fatty Acids, Omega-3 189-197 peroxisome proliferator activated receptor gamma Homo sapiens 29-38 33108021-7 2022 Interestingly, activation of PPARgamma and PPARalpha with selective agonists has been shown to decrease mesocorticolimbic DA activity and block neuropsychiatric symptoms similar to CBD and omega-3s, raising the possibility that CBD and omega-3s produce their effects through PPAR signaling. Fatty Acids, Omega-3 189-197 peroxisome proliferator activated receptor alpha Homo sapiens 43-52 33108021-7 2022 Interestingly, activation of PPARgamma and PPARalpha with selective agonists has been shown to decrease mesocorticolimbic DA activity and block neuropsychiatric symptoms similar to CBD and omega-3s, raising the possibility that CBD and omega-3s produce their effects through PPAR signaling. Fatty Acids, Omega-3 189-197 peroxisome proliferator activated receptor alpha Homo sapiens 29-33 33108021-7 2022 Interestingly, activation of PPARgamma and PPARalpha with selective agonists has been shown to decrease mesocorticolimbic DA activity and block neuropsychiatric symptoms similar to CBD and omega-3s, raising the possibility that CBD and omega-3s produce their effects through PPAR signaling. Fatty Acids, Omega-3 236-244 peroxisome proliferator activated receptor gamma Homo sapiens 29-38 33108021-7 2022 Interestingly, activation of PPARgamma and PPARalpha with selective agonists has been shown to decrease mesocorticolimbic DA activity and block neuropsychiatric symptoms similar to CBD and omega-3s, raising the possibility that CBD and omega-3s produce their effects through PPAR signaling. Fatty Acids, Omega-3 236-244 peroxisome proliferator activated receptor alpha Homo sapiens 43-52 33108021-7 2022 Interestingly, activation of PPARgamma and PPARalpha with selective agonists has been shown to decrease mesocorticolimbic DA activity and block neuropsychiatric symptoms similar to CBD and omega-3s, raising the possibility that CBD and omega-3s produce their effects through PPAR signaling. Fatty Acids, Omega-3 236-244 peroxisome proliferator activated receptor alpha Homo sapiens 29-33 33070195-0 2021 Omega-3 fatty acids improve flow-induced vasodilation by enhancing TRPV4 in arteries from diet-induced obese mice. Fatty Acids, Omega-3 0-19 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 67-72 33070195-12 2021 CONCLUSION: Omega-3 improve vascular function by improving flow-induced vasodilation via enhancing TRPV4 activity in the endothelium of obese mice which may be related to improved cell membrane physical property. Fatty Acids, Omega-3 12-19 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 99-104 33070195-13 2021 Activation of TRPV4 in endothelium plays an important role in the protective mechanisms of omega-3 against vascular dysfunction in obesity by improving flow-mediated vasodilation. Fatty Acids, Omega-3 91-98 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 14-19 33070195-14 2021 TRANSLATIONAL PERSPECTIVE: Omega-3 improve the endothelial function via enhancing TRPV4 activity and augmenting the endothelial-dependent flow-induced vasodilation in DIO mice resistance arteries. Fatty Acids, Omega-3 27-34 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 82-87 33061867-5 2020 However, such a cardioprotective effect of n-3 PUFAs has not been straightforward like for other cardiovascular drugs such as aspirin, statins or ACE inhibitors. Fatty Acids, Omega-3 43-52 angiotensin I converting enzyme Homo sapiens 146-149 33066081-1 2020 This placebo-controlled, double-blind, randomized, interventional study investigated the effects of low/intermediate doses of n-3 polyunsaturated fatty acids (PUFAs) on the endothelial function, markers of leukocyte activation, and oxidative status following dietary intake of n-3 PUFA-enriched hen eggs in young healthy individuals. Fatty Acids, Omega-3 126-157 pumilio RNA binding family member 3 Homo sapiens 159-163 33046020-11 2020 The mean intake of saturated fatty acid (SFA) decreased dramatically (P < 0.001) from 6 to 12 month; however, the median intake of n3-polyunsaturated fatty acid (n3-PUFA) intake increased (P = 0.02). Fatty Acids, Omega-3 131-160 pumilio RNA binding family member 3 Homo sapiens 165-169 31907728-12 2020 After stopping the supply of omega-3 fatty acids, the effect of Mfsd2a on inhibition of caveolae and protection of the blood-brain barrier was eliminated. Fatty Acids, Omega-3 29-48 major facilitator superfamily domain containing 2A Rattus norvegicus 64-70 32629237-8 2020 In addition, n-3 PUFA up-regulated the serotonergic pathway by increasing circulating levels of serotonin and hippocampal expression of serotonin-1A receptor, cAMP response element binding protein (CREB), pCREB, brain-derived neurotrophic factor, and miRNA-182 but did not affect the glutamatergic pathway according to the hippocampal expression of N-methyl-D-aspartate receptor-2B. Fatty Acids, Omega-3 13-21 5-hydroxytryptamine receptor 1A Rattus norvegicus 136-157 32629237-8 2020 In addition, n-3 PUFA up-regulated the serotonergic pathway by increasing circulating levels of serotonin and hippocampal expression of serotonin-1A receptor, cAMP response element binding protein (CREB), pCREB, brain-derived neurotrophic factor, and miRNA-182 but did not affect the glutamatergic pathway according to the hippocampal expression of N-methyl-D-aspartate receptor-2B. Fatty Acids, Omega-3 13-21 cAMP responsive element binding protein 1 Rattus norvegicus 159-196 32629237-8 2020 In addition, n-3 PUFA up-regulated the serotonergic pathway by increasing circulating levels of serotonin and hippocampal expression of serotonin-1A receptor, cAMP response element binding protein (CREB), pCREB, brain-derived neurotrophic factor, and miRNA-182 but did not affect the glutamatergic pathway according to the hippocampal expression of N-methyl-D-aspartate receptor-2B. Fatty Acids, Omega-3 13-21 cAMP responsive element binding protein 1 Rattus norvegicus 198-202 32629237-8 2020 In addition, n-3 PUFA up-regulated the serotonergic pathway by increasing circulating levels of serotonin and hippocampal expression of serotonin-1A receptor, cAMP response element binding protein (CREB), pCREB, brain-derived neurotrophic factor, and miRNA-182 but did not affect the glutamatergic pathway according to the hippocampal expression of N-methyl-D-aspartate receptor-2B. Fatty Acids, Omega-3 13-21 brain-derived neurotrophic factor Rattus norvegicus 212-245 32770320-5 2020 FINDING: Seafood and its derivative omega-3 polyunsaturated fatty acids (n-3 PUFAs) can suppress antigen presentation, T-cell activation, and nuclear factor-kappa B signaling pathway, modulate the overexpressed inflammatory cytokines, inhibit the expression of MMP-9, as well as regulate the expression of miRNAs and autophagy. Fatty Acids, Omega-3 36-71 matrix metallopeptidase 9 Homo sapiens 261-266 32770320-5 2020 FINDING: Seafood and its derivative omega-3 polyunsaturated fatty acids (n-3 PUFAs) can suppress antigen presentation, T-cell activation, and nuclear factor-kappa B signaling pathway, modulate the overexpressed inflammatory cytokines, inhibit the expression of MMP-9, as well as regulate the expression of miRNAs and autophagy. Fatty Acids, Omega-3 73-82 matrix metallopeptidase 9 Homo sapiens 261-266 32020589-9 2020 Moreover, PUFA-induced vasculogenesis was blunted by the PPAR-alpha inhibitor GW6471. Fatty Acids, Omega-3 10-14 peroxisome proliferator activated receptor alpha Mus musculus 57-67 31907728-13 2020 Taken together, Mfsd2a inhibits caveolae-based transcellular transport by transporting omega-3 fatty acids to protect the BBB after SAH. Fatty Acids, Omega-3 87-106 major facilitator superfamily domain containing 2A Rattus norvegicus 16-22 32622949-1 2020 AIMS: Anti-obesity effects and improved leptin sensitivity from n-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported in diet-induced obese animals. Fatty Acids, Omega-3 64-95 leptin Mus musculus 40-46 32995594-2 2020 However, the potential beneficial effect, on antidepressant treatment response, of adjunctive therapy with insulin sensitivity-enhancing lifestyle and dietary interventions (exercise; supplementation with: vitamin D, magnesium, zinc, probiotics or omega-3 fatty acids) has not been systematically explored. Fatty Acids, Omega-3 248-267 insulin Homo sapiens 107-114 32622949-1 2020 AIMS: Anti-obesity effects and improved leptin sensitivity from n-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported in diet-induced obese animals. Fatty Acids, Omega-3 97-106 leptin Mus musculus 40-46 32908639-8 2020 Moreover, we provided evidence that beta-catenin signaling activation is responsible for the sex-dependent regulation of APAP hepatotoxicity by n-3 PUFAs. Fatty Acids, Omega-3 144-153 catenin (cadherin associated protein), beta 1 Mus musculus 36-48 32912100-0 2022 Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats. Fatty Acids, Omega-3 31-50 fragile X messenger ribonucleoprotein 1 Rattus norvegicus 148-152 32912100-7 2022 To assess the impact of omega-3 PUFAs dietary supplementation during pregnancy and lactation on the altered behavior displayed by Fmr1-Deltaexon 8 rats. Fatty Acids, Omega-3 24-37 fragile X messenger ribonucleoprotein 1 Rattus norvegicus 130-134 32912100-11 2022 Juvenile and adult Fmr1-Deltaexon 8 rats showed deficits in the social and cognitive domains, that were counteracted by perinatal omega-3 PUFAs supplementation. Fatty Acids, Omega-3 130-143 fragile X messenger ribonucleoprotein 1 Rattus norvegicus 19-23 32676712-2 2020 Omega-3 desaturase (Fat-1) of Caenorhabditis elegans is able to convert n-6 PUFAs to n-3 PUFAs and thus induces a low n-6/n-3 PUFAs ratio alleviating lipid deposition. Fatty Acids, Omega-3 85-94 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 20-25 32676712-12 2020 KEY POINTS: fat-1 transgenic zebrafish (Tg:fat-1) can endogenously convert n-6 PUFAs to n-3 PUFAs. Fatty Acids, Omega-3 90-99 FAT atypical cadherin 1a Danio rerio 14-19 32676712-12 2020 KEY POINTS: fat-1 transgenic zebrafish (Tg:fat-1) can endogenously convert n-6 PUFAs to n-3 PUFAs. Fatty Acids, Omega-3 90-99 FAT atypical cadherin 1a Danio rerio 45-50 32921364-2 2020 We tested the hypothesis that parenteral omega-3 FA from a lipid emulsion that includes fish oil could be beneficial in patients with predicted SAP by reducing C-reactive protein (CRP) concentration (primary outcome), and modulating the inflammatory response and improving clinical outcome (secondary outcomes). Fatty Acids, Omega-3 41-51 C-reactive protein Homo sapiens 160-178 32921364-2 2020 We tested the hypothesis that parenteral omega-3 FA from a lipid emulsion that includes fish oil could be beneficial in patients with predicted SAP by reducing C-reactive protein (CRP) concentration (primary outcome), and modulating the inflammatory response and improving clinical outcome (secondary outcomes). Fatty Acids, Omega-3 41-51 C-reactive protein Homo sapiens 180-183 32613466-8 2020 This study suggests that n-3 PUFA has an antidepressant effect in rats exposed to combined stress, through the improvement of the HPA-axis abnormalities, the BDNF-serotonergic pathway, and the modulation of microRNAs. Fatty Acids, Omega-3 25-33 brain-derived neurotrophic factor Rattus norvegicus 158-162 32923627-7 2020 In addition, levels of omega-3 fatty acids are also decreased in Wnt signaling-deficient retinas, reflecting the basic function of MFSD2A as a lipid transporter. Fatty Acids, Omega-3 23-42 major facilitator superfamily domain containing 2A Mus musculus 131-137 32157816-0 2020 The association between plasma irisin and glucose metabolism in pregnant women is modified by dietary n-3 polyunsaturated fatty acid intake. Fatty Acids, Omega-3 102-132 fibronectin type III domain containing 5 Homo sapiens 31-37 32157816-2 2020 This study aimed to explore whether maternal plasma irisin is associated with glucose metabolism and whether this association is modified by dietary n-3 polyunsaturated fatty acid (n-3 PUFA). Fatty Acids, Omega-3 149-179 pumilio RNA binding family member 3 Homo sapiens 185-189 32639107-1 2020 The omega-3 fatty acids exert as an antioxidant via the G protein-coupled receptor 120 (GPR120). Fatty Acids, Omega-3 4-23 free fatty acid receptor 4 Rattus norvegicus 56-86 32506925-0 2020 Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease through the Resolvin E1 and ChemR23 Axis. Fatty Acids, Omega-3 0-35 chemerin chemokine-like receptor 1 Homo sapiens 94-101 32506925-2 2020 The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in cardiovascular prevention have been recently demonstrated in a large randomized controlled trial. Fatty Acids, Omega-3 26-61 pumilio RNA binding family member 3 Homo sapiens 67-71 32536300-10 2020 Positive correlations between hepatic elovl2 and fabp10a with muscle omega6:omega3 and EPA + DHA + ARA, respectively, were confirmed by reanalysing data from a previous salmon trial with lower variations in dietary EPA + DHA and omega6:omega3 ratios. Fatty Acids, Omega-3 76-82 elongation of very long chain fatty acids protein 2 Salmo salar 38-44 32536300-10 2020 Positive correlations between hepatic elovl2 and fabp10a with muscle omega6:omega3 and EPA + DHA + ARA, respectively, were confirmed by reanalysing data from a previous salmon trial with lower variations in dietary EPA + DHA and omega6:omega3 ratios. Fatty Acids, Omega-3 236-242 elongation of very long chain fatty acids protein 2 Salmo salar 38-44 32396264-8 2020 GA or omega-3-FA significantly (p < .05) prevented manganese-mediated increase in lipid peroxidation, myeloperoxidase activity, reactive oxygen and nitrogen species production but increased antioxidant enzymes activities and glutathione level in epididymis and testes treated rats. Fatty Acids, Omega-3 6-16 myeloperoxidase Rattus norvegicus 102-117 32396264-9 2020 GA or omega-3-FA enhanced the activities of testicular function marker enzymes, namely acid phosphatase (ACP), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and glucose-6-phosphate dehydrogenase (G6PD) in the treated rats. Fatty Acids, Omega-3 6-16 glucose-6-phosphate dehydrogenase Rattus norvegicus 171-204 32396264-9 2020 GA or omega-3-FA enhanced the activities of testicular function marker enzymes, namely acid phosphatase (ACP), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and glucose-6-phosphate dehydrogenase (G6PD) in the treated rats. Fatty Acids, Omega-3 6-16 glucose-6-phosphate dehydrogenase Rattus norvegicus 206-210 32304881-4 2020 Therefore, we hypothesized that omega-3 fatty acids may be of value in enhancing BDNF levels and improving cognitive function in patients with schizophrenia with metabolic syndrome (MetS). Fatty Acids, Omega-3 32-51 brain derived neurotrophic factor Homo sapiens 81-85 32304881-13 2020 Our findings provide suggestive evidence that omega-3 fatty acids have beneficial effects on cognitive function in patients with MetS, which is paralleled by enhanced BDNF levels. Fatty Acids, Omega-3 46-65 brain derived neurotrophic factor Homo sapiens 167-171 32424681-0 2020 Omega-3 offers better hypothalamus protection by decreasing POMC expression and elevating ghrelin hormone: a prospective trial to overcome methotrexate-induced anorexia. Fatty Acids, Omega-3 0-7 proopiomelanocortin Homo sapiens 60-64 32552354-7 2020 The gene expression of GPR120, a membrane receptor activated by omega-3 fatty acids, was increased in the oil-treated groups. Fatty Acids, Omega-3 64-83 free fatty acid receptor 4 Mus musculus 23-29 32401403-4 2020 The T cell mediated autoimmune diseases such as pristane induced arthritis (PIA) and autoimmune encephalomyelitis (EAE) in rats model were profoundly ameliorated by treating with the specific G protein couple receptors 120 (GPR120) stimuli Omega-3 fatty acids (omega-3 FAs). Fatty Acids, Omega-3 240-259 free fatty acid receptor 4 Rattus norvegicus 224-230 32639107-1 2020 The omega-3 fatty acids exert as an antioxidant via the G protein-coupled receptor 120 (GPR120). Fatty Acids, Omega-3 4-23 free fatty acid receptor 4 Rattus norvegicus 88-94 32698885-10 2020 However, n-3 polyunsaturated fatty acids (PUFAs) were inversely associated with CD8low but not CD8high cancers (CD8low ORT3 vs T1 = 0.45, 95% CI 0.23-0.87, Ptrend = 0.02; CD8high ORT3 vs T1 = 1.19, 95% CI 0.62-2.26, Ptrend = 0.62; Phet = 0.04). Fatty Acids, Omega-3 9-40 CD8a molecule Homo sapiens 80-83 32722083-7 2020 The performed tests demonstrated that the consumption of omega-3 enriched meat and eggs significantly increases the content of n-3 PUFA in the erythrocytes, which are a long-term indicator of fatty acid intake. Fatty Acids, Omega-3 57-64 pumilio RNA binding family member 3 Homo sapiens 131-135 32708453-5 2020 PC contained higher amounts of omega-3 polyunsaturated fatty acids (n-3 PUFA) and thus the lowest n-6/n-3 ratio. Fatty Acids, Omega-3 31-66 pumilio RNA binding family member 3 Homo sapiens 72-76 32348741-0 2020 Omega-3 fatty acids protect against acetaminophen-induced hepatic and renal toxicity in rats through HO-1-Nrf2-BACH1 pathway. Fatty Acids, Omega-3 0-19 heme oxygenase 1 Rattus norvegicus 101-105 32348741-0 2020 Omega-3 fatty acids protect against acetaminophen-induced hepatic and renal toxicity in rats through HO-1-Nrf2-BACH1 pathway. Fatty Acids, Omega-3 0-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 106-110 32348741-13 2020 Antioxidant Nrf2, its regulators (HO-1 and BACH1) and the anti-inflammatory cytokine (IL-10) were up-regulated by APAP administration as a compensatory mechanism and they were normalized by omega-3 fatty acids. Fatty Acids, Omega-3 190-209 NFE2 like bZIP transcription factor 2 Rattus norvegicus 12-16 32348741-13 2020 Antioxidant Nrf2, its regulators (HO-1 and BACH1) and the anti-inflammatory cytokine (IL-10) were up-regulated by APAP administration as a compensatory mechanism and they were normalized by omega-3 fatty acids. Fatty Acids, Omega-3 190-209 heme oxygenase 1 Rattus norvegicus 34-38 32348741-0 2020 Omega-3 fatty acids protect against acetaminophen-induced hepatic and renal toxicity in rats through HO-1-Nrf2-BACH1 pathway. Fatty Acids, Omega-3 0-19 BTB domain and CNC homolog 1 Rattus norvegicus 111-116 32348741-13 2020 Antioxidant Nrf2, its regulators (HO-1 and BACH1) and the anti-inflammatory cytokine (IL-10) were up-regulated by APAP administration as a compensatory mechanism and they were normalized by omega-3 fatty acids. Fatty Acids, Omega-3 190-209 interleukin 10 Rattus norvegicus 86-91 32348741-14 2020 omega-3 fatty acids showed anti-inflammatory actions through down-regulating nuclear factor kappa B (NF-kB) and its downstream TNF-alpha. Fatty Acids, Omega-3 0-19 nuclear factor kappa B subunit 1 Rattus norvegicus 77-99 32595696-9 2020 Cells treated with n-3 PUFAs had significantly less (P < 0.05) expression of the brown adipocyte marker genes PGC1alpha, DIO2, and UCP3. Fatty Acids, Omega-3 19-28 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 110-119 32348741-14 2020 omega-3 fatty acids showed anti-inflammatory actions through down-regulating nuclear factor kappa B (NF-kB) and its downstream TNF-alpha. Fatty Acids, Omega-3 0-19 nuclear factor kappa B subunit 1 Rattus norvegicus 101-106 32348741-14 2020 omega-3 fatty acids showed anti-inflammatory actions through down-regulating nuclear factor kappa B (NF-kB) and its downstream TNF-alpha. Fatty Acids, Omega-3 0-19 tumor necrosis factor Rattus norvegicus 127-136 32348741-15 2020 Moreover, Western blot analysis showed that omega-3 fatty acids promoted Nrf2 translocation to the nucleus; BACH1 exit from the nucleus and inhibited NF-kB nuclear translocation. Fatty Acids, Omega-3 44-63 NFE2 like bZIP transcription factor 2 Rattus norvegicus 73-77 32348741-15 2020 Moreover, Western blot analysis showed that omega-3 fatty acids promoted Nrf2 translocation to the nucleus; BACH1 exit from the nucleus and inhibited NF-kB nuclear translocation. Fatty Acids, Omega-3 44-63 nuclear factor kappa B subunit 1 Rattus norvegicus 150-155 32348741-16 2020 These findings suggested the protecting actions of omega-3 fatty acids against APAP-induced hepatic and renal toxicity through regulation of antioxidant Nrf2 and inflammatory NF-kB pathways. Fatty Acids, Omega-3 51-70 NFE2 like bZIP transcription factor 2 Rattus norvegicus 153-157 32348741-16 2020 These findings suggested the protecting actions of omega-3 fatty acids against APAP-induced hepatic and renal toxicity through regulation of antioxidant Nrf2 and inflammatory NF-kB pathways. Fatty Acids, Omega-3 51-70 nuclear factor kappa B subunit 1 Rattus norvegicus 175-180 32138466-11 2020 Conclusion: These results confirm that EPA is a tumor suppressor in human ovarian clear cell carcinoma cells and functions through a novel fatty acid receptor, GPR30, indicating a mechanistic linkage between omega-3 fatty acids and cancers. Fatty Acids, Omega-3 208-227 G protein-coupled estrogen receptor 1 Homo sapiens 160-165 31984565-7 2020 The concentration of n-3 polyunsaturated fatty acids (PUFAs) was greater in Tibetan sheep meat but saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and n-6 PUFA did not differ between breeds. Fatty Acids, Omega-3 21-52 PUFA Ovis aries 54-58 32616795-0 2020 Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain. Fatty Acids, Omega-3 80-98 brain-derived neurotrophic factor Rattus norvegicus 7-11 32616795-8 2020 These results show that the plasma BDNF is more reliable than the erythrocyte index as biomarker for assessing the effectiveness of omega-3 supplements in improving brain function. Fatty Acids, Omega-3 132-139 brain derived neurotrophic factor Mus musculus 35-39 31074595-8 2020 Both lupus activity and Patient-Reported Outcomes Measurement Information System (PROMIS) sleep disturbance scores were lower with each 1-gram/1,000 kcal increase of n-3 fatty acids (SLAQ regression coefficient beta = -0.8 [95% CI -1.6, 0.0]; P = 0.055; PROMIS sleep beta = -1.1 [95% CI -2.0, -0.2]; P = 0.017). Fatty Acids, Omega-3 166-181 immunoglobulin kappa variable 3D-20 Homo sapiens 267-278 32474355-9 2020 In India, n-3 fatty acid status is further reduced by higher intake of n-6 PUFA rich oils and trans fats. Fatty Acids, Omega-3 10-24 pumilio RNA binding family member 3 Homo sapiens 75-79 32595696-9 2020 Cells treated with n-3 PUFAs had significantly less (P < 0.05) expression of the brown adipocyte marker genes PGC1alpha, DIO2, and UCP3. Fatty Acids, Omega-3 19-28 deiodinase, iodothyronine, type II Mus musculus 121-125 32595696-9 2020 Cells treated with n-3 PUFAs had significantly less (P < 0.05) expression of the brown adipocyte marker genes PGC1alpha, DIO2, and UCP3. Fatty Acids, Omega-3 19-28 uncoupling protein 3 (mitochondrial, proton carrier) Mus musculus 131-135 32545480-0 2020 n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR-pMHC Interaction of Anti-Viral CD8+ T Cells. Fatty Acids, Omega-3 0-31 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 43-46 32595696-10 2020 Expression of mitochondrial biogenesis-related genes TFAM, PGC1alpha, and PGC1beta were significantly downregulated (P < 0.05) by n-3 PUFAs treatment. Fatty Acids, Omega-3 130-139 transcription factor A, mitochondrial Mus musculus 53-57 32545480-0 2020 n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR-pMHC Interaction of Anti-Viral CD8+ T Cells. Fatty Acids, Omega-3 0-31 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 64-67 32545480-0 2020 n-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR-pMHC Interaction of Anti-Viral CD8+ T Cells. Fatty Acids, Omega-3 0-31 CD8a molecule Homo sapiens 99-102 32545480-4 2020 The expansion of anti-viral CD8+ T cells that endogenously synthesize n-3 PUFAs (FAT-1) dramatically decreased upon lymphocytic choriomeningitis virus (LCMV) infection in vivo. Fatty Acids, Omega-3 70-79 CD8a molecule Homo sapiens 28-31 32595696-10 2020 Expression of mitochondrial biogenesis-related genes TFAM, PGC1alpha, and PGC1beta were significantly downregulated (P < 0.05) by n-3 PUFAs treatment. Fatty Acids, Omega-3 130-139 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 59-68 32545480-4 2020 The expansion of anti-viral CD8+ T cells that endogenously synthesize n-3 PUFAs (FAT-1) dramatically decreased upon lymphocytic choriomeningitis virus (LCMV) infection in vivo. Fatty Acids, Omega-3 70-79 FAT atypical cadherin 1 Homo sapiens 81-86 32595696-10 2020 Expression of mitochondrial biogenesis-related genes TFAM, PGC1alpha, and PGC1beta were significantly downregulated (P < 0.05) by n-3 PUFAs treatment. Fatty Acids, Omega-3 130-139 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 74-82 32545480-9 2020 Collectively, our results reveal a novel mechanism through which n-3 PUFAs decrease TCR-pMHC interactions by modulating TCR mobility on CD8+ T cell surfaces. Fatty Acids, Omega-3 65-74 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 84-87 32595696-11 2020 Expression of mitochondrial electron transportation chain (ETC)-regulated genes were significantly inhibited (P < 0.05) by n-3 PUFAs, including ATP5J2, COX7a1, and COX8b. Fatty Acids, Omega-3 123-132 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 Mus musculus 144-150 32545480-9 2020 Collectively, our results reveal a novel mechanism through which n-3 PUFAs decrease TCR-pMHC interactions by modulating TCR mobility on CD8+ T cell surfaces. Fatty Acids, Omega-3 65-74 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 120-123 32545480-9 2020 Collectively, our results reveal a novel mechanism through which n-3 PUFAs decrease TCR-pMHC interactions by modulating TCR mobility on CD8+ T cell surfaces. Fatty Acids, Omega-3 65-74 CD8a molecule Homo sapiens 136-139 32595696-11 2020 Expression of mitochondrial electron transportation chain (ETC)-regulated genes were significantly inhibited (P < 0.05) by n-3 PUFAs, including ATP5J2, COX7a1, and COX8b. Fatty Acids, Omega-3 123-132 cytochrome c oxidase subunit 7A1 Mus musculus 152-158 32595696-11 2020 Expression of mitochondrial electron transportation chain (ETC)-regulated genes were significantly inhibited (P < 0.05) by n-3 PUFAs, including ATP5J2, COX7a1, and COX8b. Fatty Acids, Omega-3 123-132 cytochrome c oxidase subunit 8B Mus musculus 164-169 33520859-8 2020 However, omega-3 PUFA significantly increased serum concentrations of HDL-cholesterol (WMD: 3.10; 95% CI: 0.18, 6.03) and reduced C-reactive protein (WMD: -1.85; 95% CI: -2.61, -1.09). Fatty Acids, Omega-3 9-21 C-reactive protein Homo sapiens 130-148 32504953-1 2020 Omega-3 polyunsaturated fatty acids (N3-PUFA) are widely reported to improve obesity-associated metabolic impairments, in part, through the regulation of adipokine and cytokine secretion from white adipose tissue (WAT). Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 40-44 32504049-0 2021 N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. Fatty Acids, Omega-3 0-31 brain derived neurotrophic factor Homo sapiens 70-82 32504049-7 2021 During astrocyte differentiation, we found that n-3 PUFAs increased GFAP expression and GFAP positive cell formation. Fatty Acids, Omega-3 48-57 glial fibrillary acidic protein Homo sapiens 68-72 32504049-7 2021 During astrocyte differentiation, we found that n-3 PUFAs increased GFAP expression and GFAP positive cell formation. Fatty Acids, Omega-3 48-57 glial fibrillary acidic protein Homo sapiens 88-92 32397743-3 2020 FADS1 encodes a rate-limiting enzyme for omega-3 and omega-6 fatty acid metabolism. Fatty Acids, Omega-3 41-48 fatty acid desaturase 1 Homo sapiens 0-5 32566179-8 2020 A significant (p < .05) reduction in blood pressure by 8.34/8.67 mm/Hg and insulin level was observed due to omega-3 egg consumption which indicates that omega-3 fatty acids improve insulin sensitivity. Fatty Acids, Omega-3 109-116 insulin Homo sapiens 75-82 32430018-11 2020 Chia is an accessible vegetal source of omega-3 fatty acids, antioxidants, and fiber, which could have the potential to prevent metabolic abnormalities in NAFLD patients. Fatty Acids, Omega-3 40-59 chitinase acidic Homo sapiens 0-4 30231792-7 2020 However, notably decreased high sensitivity C-reactive protein (hs-CRP) is revealed after omega-3 fatty acids supplementation (std. Fatty Acids, Omega-3 90-109 C-reactive protein Homo sapiens 44-62 32087424-1 2020 BACKGROUND: Temporality of the association of low omega-3 polyunsaturated fatty acid (n-3 PUFA) plasma levels with depression remains questionable. Fatty Acids, Omega-3 50-84 pumilio RNA binding family member 3 Homo sapiens 90-94 32486013-4 2020 We found that omega-3 PUFAs significantly improved Abeta-induced mitochondrial pathology in fat-1 mice. Fatty Acids, Omega-3 14-27 amyloid beta (A4) precursor protein Mus musculus 51-56 32486013-4 2020 We found that omega-3 PUFAs significantly improved Abeta-induced mitochondrial pathology in fat-1 mice. Fatty Acids, Omega-3 14-27 FAT atypical cadherin 1 Mus musculus 92-97 31781992-0 2020 Endoplasmic reticulum retention signaling and transmembrane channel proteins predicted for oilseed omega3 fatty acid desaturase 3 (FAD3) genes. Fatty Acids, Omega-3 99-116 omega-3 fatty acid desaturase, endoplasmic reticulum Brassica napus 131-135 31781992-9 2020 Additionally, it was found that BnFAD3 is a transmembrane protein that can convert omega6 to omega3 fatty acids and may simultaneously act as a potassium ion channel in the ER. Fatty Acids, Omega-3 93-111 omega-3 fatty acid desaturase, endoplasmic reticulum Brassica napus 32-38 32014347-3 2020 Considering that omega-3 fatty acid reduces subclinical inflammation, we hypothesized that fish oil could affect insulin resistance and AIP. Fatty Acids, Omega-3 17-35 insulin Homo sapiens 113-120 32566179-8 2020 A significant (p < .05) reduction in blood pressure by 8.34/8.67 mm/Hg and insulin level was observed due to omega-3 egg consumption which indicates that omega-3 fatty acids improve insulin sensitivity. Fatty Acids, Omega-3 109-116 insulin Homo sapiens 182-189 32566179-8 2020 A significant (p < .05) reduction in blood pressure by 8.34/8.67 mm/Hg and insulin level was observed due to omega-3 egg consumption which indicates that omega-3 fatty acids improve insulin sensitivity. Fatty Acids, Omega-3 154-173 insulin Homo sapiens 75-82 32566179-8 2020 A significant (p < .05) reduction in blood pressure by 8.34/8.67 mm/Hg and insulin level was observed due to omega-3 egg consumption which indicates that omega-3 fatty acids improve insulin sensitivity. Fatty Acids, Omega-3 154-173 insulin Homo sapiens 182-189 32382573-1 2020 Purpose: This systematic review and meta-analysis was performed to determine the effectiveness of Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplement on muscle soreness after eccentric exercise. Fatty Acids, Omega-3 98-132 pumilio RNA binding family member 3 Homo sapiens 138-142 32327735-8 2021 Here we showed that n-3 PUFAs and escitalopram (selective serotonin reuptake inhibitors, SSRIs) treatment increased adenylyl cyclase (AC) and BDNF gene expression in LCLs. Fatty Acids, Omega-3 20-29 brain derived neurotrophic factor Homo sapiens 142-146 31902378-4 2020 Omega-3 fatty acids intake upregulated peroxisome proliferator-activated receptor gamma (P<0.001) and low-density lipoprotein receptor (P=0.004), and downregulated gene expression of interleukin-1 (P=0.002) and tumor necrosis factor alpha (P=0.001) in peripheral blood mononuclear cells of subjects with GDM. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor gamma Homo sapiens 39-87 32295649-0 2020 Transgenic conversion of omega-6 to omega-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis. Fatty Acids, Omega-3 36-71 FAT atypical cadherin 1 Mus musculus 76-81 31902378-4 2020 Omega-3 fatty acids intake upregulated peroxisome proliferator-activated receptor gamma (P<0.001) and low-density lipoprotein receptor (P=0.004), and downregulated gene expression of interleukin-1 (P=0.002) and tumor necrosis factor alpha (P=0.001) in peripheral blood mononuclear cells of subjects with GDM. Fatty Acids, Omega-3 0-19 low density lipoprotein receptor Homo sapiens 105-137 31902378-4 2020 Omega-3 fatty acids intake upregulated peroxisome proliferator-activated receptor gamma (P<0.001) and low-density lipoprotein receptor (P=0.004), and downregulated gene expression of interleukin-1 (P=0.002) and tumor necrosis factor alpha (P=0.001) in peripheral blood mononuclear cells of subjects with GDM. Fatty Acids, Omega-3 0-19 interleukin 1 alpha Homo sapiens 186-199 31902378-4 2020 Omega-3 fatty acids intake upregulated peroxisome proliferator-activated receptor gamma (P<0.001) and low-density lipoprotein receptor (P=0.004), and downregulated gene expression of interleukin-1 (P=0.002) and tumor necrosis factor alpha (P=0.001) in peripheral blood mononuclear cells of subjects with GDM. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 214-241 31902378-5 2020 In addition, omega-3 fatty acids supplementation reduced fasting plasma glucose (P=0.001), insulin levels (P=0.001) and insulin resistance (P<0.001), and increased insulin sensitivity (P=0.005) when compared with the placebo. Fatty Acids, Omega-3 13-32 insulin Homo sapiens 91-98 31902378-5 2020 In addition, omega-3 fatty acids supplementation reduced fasting plasma glucose (P=0.001), insulin levels (P=0.001) and insulin resistance (P<0.001), and increased insulin sensitivity (P=0.005) when compared with the placebo. Fatty Acids, Omega-3 13-32 insulin Homo sapiens 120-127 31902378-5 2020 In addition, omega-3 fatty acids supplementation reduced fasting plasma glucose (P=0.001), insulin levels (P=0.001) and insulin resistance (P<0.001), and increased insulin sensitivity (P=0.005) when compared with the placebo. Fatty Acids, Omega-3 13-32 insulin Homo sapiens 120-127 31902378-7 2020 Omega-3 fatty acids administration was also associated with a significant reduction in high sensitivity C-reactive protein (P=0.006) and malondialdehyde (P<0.001), and an increase in total nitrite (P<0.001) and total glutathione levels (P=0.006) when compared with the placebo. Fatty Acids, Omega-3 0-19 C-reactive protein Homo sapiens 104-122 31902378-8 2020 Omega-3 fatty acids supplementation for 6 weeks to women with GDM had beneficial effects on gene expression related to insulin, lipid and inflammation, glycemic control, lipids, inflammatory markers and oxidative stress.This study was registered in the Iranian website (www.irct.ir) for registration of clinical trials (http://www.irct.ir: IRCT20170513033941N42). Fatty Acids, Omega-3 0-19 insulin Homo sapiens 119-126 32029482-0 2020 n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Muller BDNF in Diabetic Retinopathy. Fatty Acids, Omega-3 0-14 brain-derived neurotrophic factor Rattus norvegicus 107-111 31978277-5 2020 Administration of a high-fat diet rich in n-3 fatty acids (HFO) to lipoatrophic mice enriched liver with n-3 fatty acids, reduced hepatic steatosis, FAS content and activity, apoptosis, inflammation and improved glucose homeostasis. Fatty Acids, Omega-3 42-57 fatty acid synthase Mus musculus 149-152 32194222-0 2020 Improvement of NRF2 gene expression and antioxidant status in patients with type 2 diabetes mellitus after supplementation with omega-3 polyunsaturated fatty acids: A double-blind randomised placebo-controlled clinical trial. Fatty Acids, Omega-3 128-163 NFE2 like bZIP transcription factor 2 Homo sapiens 15-19 32194222-2 2020 OBJECTIVES: The aim of this research was to study the effect of supplementation with n-3 PUFAs on the antioxidant status and the gene expression of Nrf2 and Sestrin2 (Sesn2) in patients with type 2 diabetes mellitus (T2DM). Fatty Acids, Omega-3 85-94 NFE2 like bZIP transcription factor 2 Homo sapiens 148-152 32194222-2 2020 OBJECTIVES: The aim of this research was to study the effect of supplementation with n-3 PUFAs on the antioxidant status and the gene expression of Nrf2 and Sestrin2 (Sesn2) in patients with type 2 diabetes mellitus (T2DM). Fatty Acids, Omega-3 85-94 sestrin 2 Homo sapiens 157-165 32194222-2 2020 OBJECTIVES: The aim of this research was to study the effect of supplementation with n-3 PUFAs on the antioxidant status and the gene expression of Nrf2 and Sestrin2 (Sesn2) in patients with type 2 diabetes mellitus (T2DM). Fatty Acids, Omega-3 85-94 sestrin 2 Homo sapiens 167-172 32194222-10 2020 CONCLUSION: Supplementation with n-3 PUFAs enhanced NRF2 gene expression and improved overall antioxidant capacity and thus might be considered beneficial in the amelioration of oxidative stress and prevention of T2DM complications. Fatty Acids, Omega-3 33-42 NFE2 like bZIP transcription factor 2 Homo sapiens 52-56 31950220-0 2020 n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish. Fatty Acids, Omega-3 4-8 fatty acid binding protein 2, intestinal Danio rerio 29-34 31787466-1 2020 The eicosapentaenoic acid (EPA) is an n-3 polyunsaturated fatty acid (PUFA) present in the lipid composition of bovine oocytes. Fatty Acids, Omega-3 38-68 PUFA Bos taurus 70-74 31948661-4 2020 We hypothesized that insulin resistance modifies the therapeutic effect of O-3FA on post-MI cardiac remodeling. Fatty Acids, Omega-3 75-80 insulin Homo sapiens 21-28 31948661-12 2020 During the convalescent phase of acute infarct healing, patients with lower insulin resistance estimated by LAR appear to derive more therapeutic response from O-3FA toward improvement of LVESVI. Fatty Acids, Omega-3 160-165 insulin Homo sapiens 76-83 32138806-0 2020 Are marine n-3 fatty acids protective towards insulin resistance? Fatty Acids, Omega-3 11-26 insulin Homo sapiens 46-53 32138806-2 2020 Marine n-3 fatty acids improve most of the biochemical alterations associated with insulin resistance (IR). Fatty Acids, Omega-3 7-22 insulin Homo sapiens 83-90 32143275-1 2020 As major components of neuronal membranes, omega-3 polyunsaturated fatty acids (n-3 PUFA) exhibit a wide range of regulatory functions. Fatty Acids, Omega-3 43-78 pumilio RNA binding family member 3 Homo sapiens 84-88 31950220-9 2020 In conclusion, this study suggests that teleost fish fabp2 could promote intestinal n-3 PUFA absorption to mediate TAG synthesis and CL homeostasis, by regulating the genes involved in lipid metabolism. Fatty Acids, Omega-3 88-92 fatty acid binding protein 2, intestinal Danio rerio 53-58 31870843-3 2020 GPR120 is a recently identified omega-3 fatty acid receptor. Fatty Acids, Omega-3 32-50 free fatty acid receptor 4 Homo sapiens 0-6 31545905-8 2020 In MDA-MB231 cells, incubations with curcumin, quercetin, and somatostatin + quercetin induced the most significant membrane remodeling with the increase of stearic acid, diminution of omega6 linoleic, arachidonic acids, and omega3 (docosapentaenoic and docosahexaenoic acids). Fatty Acids, Omega-3 225-231 somatostatin Homo sapiens 62-74 31433904-2 2020 Some studies have reported an association between self-reported intake of n-3 polyunsaturated fatty acids (PUFAs) and serum resistin levels. Fatty Acids, Omega-3 74-105 resistin Homo sapiens 124-132 31433904-12 2020 Consumption of a large amount of n-3 PUFAs might have desirable effects on resistin-mediated diseases. Fatty Acids, Omega-3 33-42 resistin Homo sapiens 75-83 31928966-3 2020 Variants near ELOVL2 have repeatedly been associated with levels of LC-PUFA-derived metabolites in genome-wide association studies (GWAS), but the mechanisms behind these observations remain poorly defined. Fatty Acids, Omega-3 71-75 ELOVL fatty acid elongase 2 Homo sapiens 14-20 32037984-3 2022 Our data reveal a long-lasting impact of perinatal omega-3 fatty acid supplementation on hippocampal nerve growth factor levels mediated by reduced 3-hydroxy 3-methylglutaryl Coenzyme A reductase activation state and enhanced CREB signaling.Discussion: These data underline the importance of the perinatal omega-3 enriched diet for adult brain function and reveal a new pathway important for nerve growth factor regulation. Fatty Acids, Omega-3 51-69 nerve growth factor Homo sapiens 101-120 32037984-3 2022 Our data reveal a long-lasting impact of perinatal omega-3 fatty acid supplementation on hippocampal nerve growth factor levels mediated by reduced 3-hydroxy 3-methylglutaryl Coenzyme A reductase activation state and enhanced CREB signaling.Discussion: These data underline the importance of the perinatal omega-3 enriched diet for adult brain function and reveal a new pathway important for nerve growth factor regulation. Fatty Acids, Omega-3 51-69 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 148-195 32037984-3 2022 Our data reveal a long-lasting impact of perinatal omega-3 fatty acid supplementation on hippocampal nerve growth factor levels mediated by reduced 3-hydroxy 3-methylglutaryl Coenzyme A reductase activation state and enhanced CREB signaling.Discussion: These data underline the importance of the perinatal omega-3 enriched diet for adult brain function and reveal a new pathway important for nerve growth factor regulation. Fatty Acids, Omega-3 51-69 cAMP responsive element binding protein 1 Homo sapiens 226-230 32037984-3 2022 Our data reveal a long-lasting impact of perinatal omega-3 fatty acid supplementation on hippocampal nerve growth factor levels mediated by reduced 3-hydroxy 3-methylglutaryl Coenzyme A reductase activation state and enhanced CREB signaling.Discussion: These data underline the importance of the perinatal omega-3 enriched diet for adult brain function and reveal a new pathway important for nerve growth factor regulation. Fatty Acids, Omega-3 51-69 nerve growth factor Homo sapiens 392-411 31639282-5 2020 Additionally, omega-3FA administration markedly suppressed the increase in hepatic and renal myeloperoxidase activity, nitric oxide, tumor necrosis factor alpha, and interleukin-1 beta levels in the co-exposure group. Fatty Acids, Omega-3 14-23 myeloperoxidase Rattus norvegicus 93-108 31639282-5 2020 Additionally, omega-3FA administration markedly suppressed the increase in hepatic and renal myeloperoxidase activity, nitric oxide, tumor necrosis factor alpha, and interleukin-1 beta levels in the co-exposure group. Fatty Acids, Omega-3 14-23 tumor necrosis factor Rattus norvegicus 133-160 31639282-5 2020 Additionally, omega-3FA administration markedly suppressed the increase in hepatic and renal myeloperoxidase activity, nitric oxide, tumor necrosis factor alpha, and interleukin-1 beta levels in the co-exposure group. Fatty Acids, Omega-3 14-23 interleukin 1 beta Rattus norvegicus 166-184 31797565-5 2020 Supplementation of the biosynthetic intermediates of SPM (e.g., 17-hydroxy-DHA) or omega-3 fatty acids increases the level of adipose SPMs, reduces adipose inflammation (decrease in macrophage accumulation and change to less inflammatory macrophages), and enhances insulin sensitivity. Fatty Acids, Omega-3 83-102 insulin Homo sapiens 265-272 31698142-13 2020 In addition, heme oxygenase-1 (HO-1) which protects tubular function was also up-regulated in the treatment group receiving n3-PUFA supplemented chow. Fatty Acids, Omega-3 124-131 heme oxygenase 1 Mus musculus 13-29 31928474-2 2020 Chia seeds are used to treat certain noncommunicable diseases, and they are rich in omega-3 fatty acids, which contribute to the absorption of vitamins. Fatty Acids, Omega-3 84-103 chitinase acidic Homo sapiens 0-4 30905498-1 2020 BACKGROUND & AIMS: Dietary and supplemental long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) have shown vascular benefits for the general population, but effects among people with chronic kidney disease (CKD) are largely uncertain. Fatty Acids, Omega-3 59-94 pumilio RNA binding family member 3 Homo sapiens 100-104 31715372-11 2020 Relative to the diabetic control, treatments with omega-3 or metformin caused significant elevations in hepatic glycogen, total alkaline phosphatase (TALP), osteocalcin, PTH, estradiol, and calcium; however, significant decreases in TRAP and glucose. Fatty Acids, Omega-3 50-57 bone gamma-carboxyglutamate protein Rattus norvegicus 157-168 31630038-1 2020 BACKGROUND: To study the association of n-3 polyunsaturated fatty acid (n-3 PUFA) intake from diet with depressive symptoms in midlife women. Fatty Acids, Omega-3 40-70 pumilio RNA binding family member 3 Homo sapiens 76-80 31947691-0 2020 Suppression of beta1-Adrenoceptor Autoantibodies is Involved in the Antiarrhythmic Effects of Omega-3 Fatty Acids in Male and Female Hypertensive Rats. Fatty Acids, Omega-3 94-113 adrenoceptor beta 1 Rattus norvegicus 15-33 31952247-7 2020 Yet, several studies have shown that omega 3 fatty acids (FA) could prevent the development of RA, improve muscle metabolism and limit muscle atrophy in obese and insulin-resistant subjects. Fatty Acids, Omega-3 37-56 insulin Homo sapiens 163-170 31715372-11 2020 Relative to the diabetic control, treatments with omega-3 or metformin caused significant elevations in hepatic glycogen, total alkaline phosphatase (TALP), osteocalcin, PTH, estradiol, and calcium; however, significant decreases in TRAP and glucose. Fatty Acids, Omega-3 50-57 parathyroid hormone Rattus norvegicus 170-173 31715372-11 2020 Relative to the diabetic control, treatments with omega-3 or metformin caused significant elevations in hepatic glycogen, total alkaline phosphatase (TALP), osteocalcin, PTH, estradiol, and calcium; however, significant decreases in TRAP and glucose. Fatty Acids, Omega-3 50-57 acid phosphatase 5, tartrate resistant Rattus norvegicus 233-237 31232084-5 2020 It is put forward that some nutrients such as dairy products, curcumin, niacin, palmitate, coffee and alcohol consumption decrease fetuin-A level, and dietary omega-3 fatty acids intake may increase fetuin-A concentration. Fatty Acids, Omega-3 159-178 alpha 2-HS glycoprotein Homo sapiens 199-207 32053089-3 2020 OBJECTIVE: To analyse the effect of supplementation with n-3 fatty acids extracted from microalgae on the total antioxidant capacity (TAC) and lipid peroxidation of adipose tissue and plasma from diabetic (db/db) and healthy (CD1) mice. Fatty Acids, Omega-3 57-72 CD1 antigen complex Mus musculus 226-229 33395685-3 2020 Prenatal exposure to omega-3 fatty acids improved reductions in the number of calls produced by Fmr1heterozygotes females. Fatty Acids, Omega-3 21-40 fragile X messenger ribonucleoprotein 1 Mus musculus 96-100 33373352-3 2020 From observation in epidemiological studies that demonstrated longer pregnancies in populations with high consumption of marine oils, attempts have been made to define the benefit of omega-3 polyunsaturated fatty acids (n-3 PUFA) prevention in premature childbirth through randomized clinical trials, as well as its preventive value. Fatty Acids, Omega-3 183-218 pumilio RNA binding family member 3 Homo sapiens 224-228 32000355-17 2020 As for decreasing BNP, omega-3 was better than placebo (941.99 (-47.48, 1952.89) and was the best therapy for improving ventricle wall tension. Fatty Acids, Omega-3 23-30 natriuretic peptide B Homo sapiens 18-21 31106659-4 2020 After 8 weeks of intervention, patients who received combined vitamin D3 and omega-3 fatty acids supplements compared with omega-3, vitamin D3, and placebo groups had significantly decreased CRP and TNF-alpha. Fatty Acids, Omega-3 77-96 C-reactive protein Homo sapiens 191-194 31106659-4 2020 After 8 weeks of intervention, patients who received combined vitamin D3 and omega-3 fatty acids supplements compared with omega-3, vitamin D3, and placebo groups had significantly decreased CRP and TNF-alpha. Fatty Acids, Omega-3 77-96 tumor necrosis factor Homo sapiens 199-208 31106659-4 2020 After 8 weeks of intervention, patients who received combined vitamin D3 and omega-3 fatty acids supplements compared with omega-3, vitamin D3, and placebo groups had significantly decreased CRP and TNF-alpha. Fatty Acids, Omega-3 77-84 C-reactive protein Homo sapiens 191-194 31106659-4 2020 After 8 weeks of intervention, patients who received combined vitamin D3 and omega-3 fatty acids supplements compared with omega-3, vitamin D3, and placebo groups had significantly decreased CRP and TNF-alpha. Fatty Acids, Omega-3 77-84 tumor necrosis factor Homo sapiens 199-208 31106659-5 2020 In addition, serum level of IL-6 was decreased significantly in omega-3, vitamin D3, and cosupplementation groups compared with baseline. Fatty Acids, Omega-3 64-71 interleukin 6 Homo sapiens 28-32 33009536-0 2020 Long-Chain Omega-3 Fatty Acid Intake Is Associated with Age but not Cognitive Performance in an Older Australian Sample. Fatty Acids, Omega-3 11-29 renin binding protein Homo sapiens 56-59 33009536-1 2020 BACKGROUND: Long-chain omega-3 polyunsaturated fatty acids (LCn-3 PUFA) are essential nutrients and may be capable of delaying age-related cognitive decline. Fatty Acids, Omega-3 23-58 renin binding protein Homo sapiens 127-130 31409173-7 2020 Moreover, omega-3 fatty acid docosahexaenoic acid (DHA) showed an inhibitory effect on BMP-2 induced osteoblast-like potential presumably by abrogating BMP signaling. Fatty Acids, Omega-3 10-28 bone morphogenetic protein 2 Homo sapiens 87-92 31573353-8 2020 Conclusions: Omega-3 fatty acids may have an inhibitory effect on postoperative TNF-alpha elevation in patients with digestive system tumors, but additional supporting data require a large clinical trial. Fatty Acids, Omega-3 13-32 tumor necrosis factor Homo sapiens 80-89 31409173-7 2020 Moreover, omega-3 fatty acid docosahexaenoic acid (DHA) showed an inhibitory effect on BMP-2 induced osteoblast-like potential presumably by abrogating BMP signaling. Fatty Acids, Omega-3 10-28 bone morphogenetic protein 1 Homo sapiens 87-90 32441198-5 2020 Regarding CEA, there was no significant difference between the four groups at the end of intervention (P > .05).Conclusion: Results show that co-supplementation of vitamin D and omega-3 fatty acids co-supplementation, in colorectal cancer patients have beneficial impacts on inflammation and tumor marker CEA. Fatty Acids, Omega-3 178-197 pregnancy specific beta-1-glycoprotein 2 Homo sapiens 305-308 32441198-3 2020 In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. Fatty Acids, Omega-3 115-122 tumor necrosis factor Homo sapiens 29-38 31785633-1 2019 Dietary n-3 polyunsaturated fatty acids (n-3 PUFA) improve utero-ovarian functions and embryonic survival in postpartum dairy cows. Fatty Acids, Omega-3 8-39 PUFA Bos taurus 45-49 32441198-3 2020 In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. Fatty Acids, Omega-3 115-122 interleukin 1 alpha Homo sapiens 40-48 32441198-3 2020 In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. Fatty Acids, Omega-3 115-122 interleukin 6 Homo sapiens 50-54 32441198-3 2020 In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. Fatty Acids, Omega-3 115-122 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 32441198-3 2020 In addition, serum levels of TNF-alpha, IL-1beta, IL-6, IL-8, and tumor marker CEA were decreased significantly in omega-3, vitamin D, and co-supplementation of them, compared with baseline. Fatty Acids, Omega-3 115-122 pregnancy specific beta-1-glycoprotein 2 Homo sapiens 79-82 31908411-1 2019 Purpose: To determine if an eye drop containing omega-3 fatty acids (Refresh Optive MEGA-3 , Allergan plc, Dublin, Ireland) increases the lipid layer thickness (LLT) of the tear film versus a non-emollient eye drop (Refresh Optive, Allergan plc). Fatty Acids, Omega-3 48-67 heparan sulfate proteoglycan 2 Homo sapiens 102-105 31827125-1 2019 The purpose of this systematic review and meta-analysis was to investigate omega-3 fatty acids" influence on 12 inflammatory biomarkers-LDL, HDL, total cholesterol, TG, HbA1c, Apo AI, Apo AII, Apo B, CRP, TNF-alpha, glucose, and fasting blood glucose among diabetic and cardiovascular disease (CVD) patients. Fatty Acids, Omega-3 75-94 apolipoprotein A1 Homo sapiens 176-182 31827125-1 2019 The purpose of this systematic review and meta-analysis was to investigate omega-3 fatty acids" influence on 12 inflammatory biomarkers-LDL, HDL, total cholesterol, TG, HbA1c, Apo AI, Apo AII, Apo B, CRP, TNF-alpha, glucose, and fasting blood glucose among diabetic and cardiovascular disease (CVD) patients. Fatty Acids, Omega-3 75-94 apolipoprotein B Homo sapiens 193-198 31827125-1 2019 The purpose of this systematic review and meta-analysis was to investigate omega-3 fatty acids" influence on 12 inflammatory biomarkers-LDL, HDL, total cholesterol, TG, HbA1c, Apo AI, Apo AII, Apo B, CRP, TNF-alpha, glucose, and fasting blood glucose among diabetic and cardiovascular disease (CVD) patients. Fatty Acids, Omega-3 75-94 C-reactive protein Homo sapiens 200-203 31827125-1 2019 The purpose of this systematic review and meta-analysis was to investigate omega-3 fatty acids" influence on 12 inflammatory biomarkers-LDL, HDL, total cholesterol, TG, HbA1c, Apo AI, Apo AII, Apo B, CRP, TNF-alpha, glucose, and fasting blood glucose among diabetic and cardiovascular disease (CVD) patients. Fatty Acids, Omega-3 75-94 tumor necrosis factor Homo sapiens 205-214 31796080-3 2019 However, the effects of dietary mono- and poly-unsaturated fats (MUFA/PUFA) on nascent lipoprotein Abeta abundance have not been previously reported. Fatty Acids, Omega-3 70-74 amyloid beta (A4) precursor protein Mus musculus 99-104 31796080-7 2019 The mice maintained on MUFA or PUFA diet showed comparable enterocytic and plasma Abeta levels to the LF control mice. Fatty Acids, Omega-3 31-35 amyloid beta (A4) precursor protein Mus musculus 82-87 31817347-2 2019 Omega-3 fatty acids have been shown to induce thermogenic action in adipocytes via G-protein coupled receptor 120 (GPR120). Fatty Acids, Omega-3 0-19 free fatty acid receptor 4 Homo sapiens 83-113 31817347-2 2019 Omega-3 fatty acids have been shown to induce thermogenic action in adipocytes via G-protein coupled receptor 120 (GPR120). Fatty Acids, Omega-3 0-19 free fatty acid receptor 4 Homo sapiens 115-121 31816909-10 2019 In conclusion, the results demonstrate that ghrelin, GIP and VAS respond differently to MUFA and PUFA meals. Fatty Acids, Omega-3 97-101 gastric inhibitory polypeptide Homo sapiens 53-56 31722009-3 2019 FAT-1 mice had higher systemic (serum) and local (skin tissue) omega-3 FA levels, mainly docosahexaenoic acid (DHA), in comparison with WT mice. Fatty Acids, Omega-3 63-73 FAT atypical cadherin 1 Mus musculus 0-5 31791524-3 2019 Omega-3 fatty acid supplementation is a therapeutic strategy in humans with metabolic dysfunction that improves insulin sensitivity and reduces inflammation, but the effects of omega-3 fatty acid supplementation in horses with EMS are unclear. Fatty Acids, Omega-3 0-18 insulin Homo sapiens 112-119 31591263-0 2019 Absolute Quantification of Apolipoproteins Following Treatment with Omega-3 Carboxylic Acids and Fenofibrate Using a High Precision Stable Isotope-Labeled Recombinant Protein Fragments Based SRM Assay. Fatty Acids, Omega-3 68-92 apolipoprotein E Homo sapiens 27-42 31805709-1 2019 The protein 1alpha-hydroxylase (CYP27B1) was expressed in liver and omega-3 fatty acid (FA) elevated 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in dialysis patients. Fatty Acids, Omega-3 68-86 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 32-39 31805709-2 2019 The aim of this study was to determine whether omega-3 FA and cholecalciferol have effects on vitamin D metabolism related to CYP27B1 and 24-hydroxylase (CYP24) activities in the kidney and liver of 5/6 nephrectomy (Nx) rats. Fatty Acids, Omega-3 47-57 cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus 126-152 31805709-2 2019 The aim of this study was to determine whether omega-3 FA and cholecalciferol have effects on vitamin D metabolism related to CYP27B1 and 24-hydroxylase (CYP24) activities in the kidney and liver of 5/6 nephrectomy (Nx) rats. Fatty Acids, Omega-3 47-57 cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus 154-159 31805709-7 2019 CYP24 expression was increased in the kidney of the 5/6 Nx rat model, which was found to be reversed by omega-3 FA or cholecalciferol/omega-3 FA supplementation. Fatty Acids, Omega-3 104-114 cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus 0-5 31805709-7 2019 CYP24 expression was increased in the kidney of the 5/6 Nx rat model, which was found to be reversed by omega-3 FA or cholecalciferol/omega-3 FA supplementation. Fatty Acids, Omega-3 134-144 cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus 0-5 31805709-8 2019 Decreased CYP27B1 expression was observed in the liver of the 5/6 Nx rats and its expression was recovered by supplementation with cholecalciferol/omega-3 FA. Fatty Acids, Omega-3 147-157 cytochrome P450, family 27, subfamily b, polypeptide 1 Rattus norvegicus 10-17 31805709-9 2019 In conclusion, omega-3 FA and cholecalciferol may synergistically increase 1,25(OH)2D levels by inhibiting CYP24 expression in the kidney and liver and activating CYP27B1 expression in the liver of 5/6 Nx rats. Fatty Acids, Omega-3 15-25 cytochrome P450, family 24, subfamily a, polypeptide 1 Rattus norvegicus 107-112 31805709-9 2019 In conclusion, omega-3 FA and cholecalciferol may synergistically increase 1,25(OH)2D levels by inhibiting CYP24 expression in the kidney and liver and activating CYP27B1 expression in the liver of 5/6 Nx rats. Fatty Acids, Omega-3 15-25 cytochrome P450, family 27, subfamily b, polypeptide 1 Rattus norvegicus 163-170 31771637-0 2019 Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. Fatty Acids, Omega-3 31-50 cadherin 23 (otocadherin) Mus musculus 54-78 31761534-0 2019 Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Fatty Acids, Omega-3 0-19 free fatty acid receptor 4 Mus musculus 37-42 31761534-5 2019 We discover that TULP3-dependent ciliary localization of the omega-3 fatty acid receptor FFAR4/GPR120 promotes adipogenesis. Fatty Acids, Omega-3 61-79 tubby-like protein 3 Mus musculus 17-22 31761534-5 2019 We discover that TULP3-dependent ciliary localization of the omega-3 fatty acid receptor FFAR4/GPR120 promotes adipogenesis. Fatty Acids, Omega-3 61-79 free fatty acid receptor 4 Mus musculus 89-94 31761534-5 2019 We discover that TULP3-dependent ciliary localization of the omega-3 fatty acid receptor FFAR4/GPR120 promotes adipogenesis. Fatty Acids, Omega-3 61-79 free fatty acid receptor 4 Mus musculus 95-101 31775778-0 2019 The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus. Fatty Acids, Omega-3 15-45 toll-like receptor 4 Mus musculus 95-113 31771637-2 2019 Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Fatty Acids, Omega-3 0-41 cadherin 23 (otocadherin) Mus musculus 84-87 31694658-1 2019 BACKGROUND: Research indicates that low omega-3 polyunsaturated fatty acid (n-3 PUFA) may be associated with decreased cognitive function. Fatty Acids, Omega-3 40-74 pumilio RNA binding family member 3 Homo sapiens 80-84 31703120-11 2019 Mean change in eGFR was -12.2 (95% CI, -13.3 to -11.1) mL/min/1.73 m2 with omega-3 fatty acids vs -13.1 (95% CI, -14.2 to -12.0) mL/min/1.73 m2 with placebo (difference, 0.9 [95% CI, -0.7 to 2.6] mL/min/1.73 m2). Fatty Acids, Omega-3 75-94 epidermal growth factor receptor Homo sapiens 15-19 31729437-6 2019 Additionally, Delta6abc/5Mt demonstrated significant upregulation of the lipogenic transcription regulator, sterol regulatory element binding protein-1 (srebp-1) in liver and pyloric caeca under reduced dietary LC-PUFA. Fatty Acids, Omega-3 214-218 sterol regulatory element-binding protein 1 Salmo salar 108-151 31729437-6 2019 Additionally, Delta6abc/5Mt demonstrated significant upregulation of the lipogenic transcription regulator, sterol regulatory element binding protein-1 (srebp-1) in liver and pyloric caeca under reduced dietary LC-PUFA. Fatty Acids, Omega-3 214-218 sterol regulatory element-binding protein 1 Salmo salar 153-160 31729437-7 2019 Our data suggest a combined effect of endogenous LC-PUFA synthesis and dietary LC-PUFA levels on srebp-1 expression which ultimately affects LC-PUFA synthesis in salmon. Fatty Acids, Omega-3 52-56 sterol regulatory element-binding protein 1 Salmo salar 97-104 31729437-7 2019 Our data suggest a combined effect of endogenous LC-PUFA synthesis and dietary LC-PUFA levels on srebp-1 expression which ultimately affects LC-PUFA synthesis in salmon. Fatty Acids, Omega-3 82-86 sterol regulatory element-binding protein 1 Salmo salar 97-104 31729437-7 2019 Our data suggest a combined effect of endogenous LC-PUFA synthesis and dietary LC-PUFA levels on srebp-1 expression which ultimately affects LC-PUFA synthesis in salmon. Fatty Acids, Omega-3 82-86 sterol regulatory element-binding protein 1 Salmo salar 97-104 31518521-6 2019 Interestingly, n-3PUFA increased the infiltration of CD4+ and CD8+ T cells but did not alter the erythemal response, either the sunburn threshold or the resolution of erythema, as assessed by spectrophotometric hemoglobin index readings. Fatty Acids, Omega-3 15-22 CD4 molecule Homo sapiens 53-56 31518521-6 2019 Interestingly, n-3PUFA increased the infiltration of CD4+ and CD8+ T cells but did not alter the erythemal response, either the sunburn threshold or the resolution of erythema, as assessed by spectrophotometric hemoglobin index readings. Fatty Acids, Omega-3 15-22 CD8a molecule Homo sapiens 62-65 31660546-6 2019 The proportions of docosahexaenoic acid and n-3 polyunsaturated fatty acid (PUFA) and the ratio of PUFA to saturated fatty acid in LD muscle were increased by 400 mg kg-1 APPs. Fatty Acids, Omega-3 44-74 Polyunsaturated fatty acid percentage Sus scrofa 76-80 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Fatty Acids, Omega-3 31-50 tumor necrosis factor Rattus norvegicus 87-114 31455615-0 2019 Novel COX-2 products of n-3 polyunsaturated fatty acid-ethanolamine-conjugates identified in RAW 264.7 macrophages. Fatty Acids, Omega-3 24-54 prostaglandin-endoperoxide synthase 2 Homo sapiens 6-11 31455615-3 2019 We developed an LC-HRMS based hCOX-2 screening assay to examine its ability to also convert n-3 PUFA-derived N-acylethanolamines. Fatty Acids, Omega-3 92-100 mitochondrially encoded cytochrome c oxidase II Homo sapiens 30-36 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Fatty Acids, Omega-3 31-50 tumor necrosis factor Rattus norvegicus 116-125 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Fatty Acids, Omega-3 31-50 interleukin 1 beta Rattus norvegicus 131-148 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Fatty Acids, Omega-3 31-50 interleukin 1 beta Rattus norvegicus 150-158 31106412-9 2019 Omega-3 fatty acids only, aspirin only, or omega-3 fatty acids plus aspirin also inhibited the protein expressions of COX-2 and iNOS in LPS-stimulated RAW264.7 cells. Fatty Acids, Omega-3 0-19 cytochrome c oxidase II, mitochondrial Mus musculus 118-123 31106412-9 2019 Omega-3 fatty acids only, aspirin only, or omega-3 fatty acids plus aspirin also inhibited the protein expressions of COX-2 and iNOS in LPS-stimulated RAW264.7 cells. Fatty Acids, Omega-3 0-19 nitric oxide synthase 2, inducible Mus musculus 128-132 31106412-9 2019 Omega-3 fatty acids only, aspirin only, or omega-3 fatty acids plus aspirin also inhibited the protein expressions of COX-2 and iNOS in LPS-stimulated RAW264.7 cells. Fatty Acids, Omega-3 43-62 cytochrome c oxidase II, mitochondrial Mus musculus 118-123 31106412-9 2019 Omega-3 fatty acids only, aspirin only, or omega-3 fatty acids plus aspirin also inhibited the protein expressions of COX-2 and iNOS in LPS-stimulated RAW264.7 cells. Fatty Acids, Omega-3 43-62 nitric oxide synthase 2, inducible Mus musculus 128-132 31106412-10 2019 In addition, omega-3 combined with ASA also inhibited the RANKL-induced gene expressions of MMPs in dose-dependent manners. Fatty Acids, Omega-3 13-20 TNF superfamily member 11 Rattus norvegicus 58-63 31106412-10 2019 In addition, omega-3 combined with ASA also inhibited the RANKL-induced gene expressions of MMPs in dose-dependent manners. Fatty Acids, Omega-3 13-20 matrix metallopeptidase 2 Rattus norvegicus 92-96 31516639-5 2019 In contrast, FFAR4, which is a sensor for long-chain n-3 polyunsaturated fatty acids and also expressed on airway smooth muscle, does not contribute to airway contraction and airway smooth muscle cell proliferation. Fatty Acids, Omega-3 53-84 free fatty acid receptor 4 Homo sapiens 13-18 31671528-6 2019 phosphatidylethanolamine N-methyltransferase (PEMT) rs1109859 and methylenetetrahydrofolate reductase gene (MTHFR) rs4846052 genotypes were associated with PUFA levels in RBCs. Fatty Acids, Omega-3 156-160 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 31420792-9 2019 Supplementation of omega-3 fatty acids and vitamin E to LOP improved the levels of VEGF and VEGF receptor-1 only in the LOP but not in the EOP group. Fatty Acids, Omega-3 19-38 vascular endothelial growth factor A Rattus norvegicus 83-87 30943799-0 2019 Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat model. Fatty Acids, Omega-3 0-18 stearoyl-CoA desaturase Rattus norvegicus 54-59 30943799-6 2019 Compared to the control group, CsA-induced rats showed elevated SCD-1 expression in the kidney and liver, which omega-3 FA treatment reversed. Fatty Acids, Omega-3 112-122 stearoyl-CoA desaturase Rattus norvegicus 64-69 30943799-7 2019 Elovl-6 expression was increased in the liver, but decreased in the kidney in CsA group compared to control, which omega-3 FA treatment also reversed. Fatty Acids, Omega-3 115-125 ELOVL fatty acid elongase 6 Rattus norvegicus 0-7 30943799-8 2019 CONCLUSIONS: Omega-3 FA supplementation decreased erythrocyte membrane oleic acid content by modulating SCD-1 and Elovl-6 expression in the kidney and liver of CsA-induced rats. Fatty Acids, Omega-3 13-23 stearoyl-CoA desaturase Rattus norvegicus 104-109 30943799-8 2019 CONCLUSIONS: Omega-3 FA supplementation decreased erythrocyte membrane oleic acid content by modulating SCD-1 and Elovl-6 expression in the kidney and liver of CsA-induced rats. Fatty Acids, Omega-3 13-23 ELOVL fatty acid elongase 6 Rattus norvegicus 114-121 31671528-6 2019 phosphatidylethanolamine N-methyltransferase (PEMT) rs1109859 and methylenetetrahydrofolate reductase gene (MTHFR) rs4846052 genotypes were associated with PUFA levels in RBCs. Fatty Acids, Omega-3 156-160 methylenetetrahydrofolate reductase Homo sapiens 66-101 31671528-10 2019 Genetic variations in PEMT rs1109859 and MTHFR rs4846052 were associated with different PUFA levels in RBC membranes and are estimators for PUFA species in RBCs. Fatty Acids, Omega-3 88-92 phosphatidylethanolamine N-methyltransferase Homo sapiens 22-26 31671528-10 2019 Genetic variations in PEMT rs1109859 and MTHFR rs4846052 were associated with different PUFA levels in RBC membranes and are estimators for PUFA species in RBCs. Fatty Acids, Omega-3 88-92 methylenetetrahydrofolate reductase Homo sapiens 41-46 31671528-10 2019 Genetic variations in PEMT rs1109859 and MTHFR rs4846052 were associated with different PUFA levels in RBC membranes and are estimators for PUFA species in RBCs. Fatty Acids, Omega-3 140-144 phosphatidylethanolamine N-methyltransferase Homo sapiens 22-26 31671528-10 2019 Genetic variations in PEMT rs1109859 and MTHFR rs4846052 were associated with different PUFA levels in RBC membranes and are estimators for PUFA species in RBCs. Fatty Acids, Omega-3 140-144 methylenetetrahydrofolate reductase Homo sapiens 41-46 31513369-4 2019 We injected wild type and endogenously n-3-PUFA producing fat-1 transgenic mice with LPS (i.p., 2.5mg/kg) or PBS. Fatty Acids, Omega-3 39-47 FAT atypical cadherin 1 Mus musculus 58-63 31681849-0 2019 Zika virus degrades the omega-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis. Fatty Acids, Omega-3 24-42 major facilitator superfamily domain containing 2A Homo sapiens 55-61 31532795-0 2019 Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction-Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial. Fatty Acids, Omega-3 108-127 stearoyl-CoA desaturase Homo sapiens 21-42 31619022-0 2019 Lifelong n-3 Polyunsaturated Fatty Acid Exposure Modulates Size of Mammary Epithelial Cell Populations and Expression of Caveolae Resident Proteins in Fat-1 Mice. Fatty Acids, Omega-3 9-39 FAT atypical cadherin 1 Mus musculus 151-156 31468353-7 2019 Omega-3 fatty acid considerably improved the Cd-associated biochemical changes, reduced the elevation of lipid peroxidation, and normalized the Cd impact on the levels of superoxide dismutase, catalase, glutathione-S-transferases, 8-hydroxydeoxyguanosine, heatshock protein70, nuclear factor-kappaB, and interferon-gamma as well as of neuronal enzymes such as acetylecholinesterase and monoamine oxidase within the brains of treated rats. Fatty Acids, Omega-3 0-18 catalase Rattus norvegicus 193-201 31468353-7 2019 Omega-3 fatty acid considerably improved the Cd-associated biochemical changes, reduced the elevation of lipid peroxidation, and normalized the Cd impact on the levels of superoxide dismutase, catalase, glutathione-S-transferases, 8-hydroxydeoxyguanosine, heatshock protein70, nuclear factor-kappaB, and interferon-gamma as well as of neuronal enzymes such as acetylecholinesterase and monoamine oxidase within the brains of treated rats. Fatty Acids, Omega-3 0-18 interferon gamma Rattus norvegicus 304-320 31673534-0 2019 Endogenously increased n-3 PUFA levels in fat-1 transgenic mice do not protect from non-alcoholic steatohepatitis. Fatty Acids, Omega-3 27-31 FAT atypical cadherin 1 Mus musculus 42-47 31673534-4 2019 Herein, we examined the therapeutic effect of increased n-3 PUFA tissue levels in fat-1 transgenic mice on progressive NASH. Fatty Acids, Omega-3 60-64 FAT atypical cadherin 1 Mus musculus 82-87 31673534-7 2019 Unlike all other mammals, fat-1 transgenic mice ubiquitously express an n-3 fatty acid desaturase, which converts n-6 to n-3 PUFAs, leading to increased n-3 and decreased n-6 PUFA tissue contents. Fatty Acids, Omega-3 125-129 FAT atypical cadherin 1 Mus musculus 26-31 31673534-10 2019 Conclusions: Endogenously elevated n-3 PUFA levels in fat-1 transgenic mice transiently delay the onset of STZ/HFD induced NASH but failed to efficiently protect from NASH development. Fatty Acids, Omega-3 39-43 FAT atypical cadherin 1 Mus musculus 54-59 30887626-9 2019 Injection of macrophage clean reagent and omega-3PUFA significantly inhibited M2 activation, and decreased Masson staining, alpha-SMA, TGF-beta1, VEGF and ALK5 protein expression in peritoneal tissues in PD treated rats. Fatty Acids, Omega-3 42-53 transforming growth factor, beta 1 Rattus norvegicus 135-144 30887626-9 2019 Injection of macrophage clean reagent and omega-3PUFA significantly inhibited M2 activation, and decreased Masson staining, alpha-SMA, TGF-beta1, VEGF and ALK5 protein expression in peritoneal tissues in PD treated rats. Fatty Acids, Omega-3 42-53 vascular endothelial growth factor A Rattus norvegicus 146-150 30887626-9 2019 Injection of macrophage clean reagent and omega-3PUFA significantly inhibited M2 activation, and decreased Masson staining, alpha-SMA, TGF-beta1, VEGF and ALK5 protein expression in peritoneal tissues in PD treated rats. Fatty Acids, Omega-3 42-53 transforming growth factor, beta receptor 1 Rattus norvegicus 155-159 30887626-10 2019 omega-3PUFA injection significantly decreased PD-induced injury in ileum and normalized the expression of ZO-1 and occludin in the ileum of PD rats. Fatty Acids, Omega-3 0-11 tight junction protein 1 Rattus norvegicus 106-110 30887626-10 2019 omega-3PUFA injection significantly decreased PD-induced injury in ileum and normalized the expression of ZO-1 and occludin in the ileum of PD rats. Fatty Acids, Omega-3 0-11 occludin Rattus norvegicus 115-123 31532795-3 2019 METHODS AND RESULTS: We tested the hypothesis that the genotypic status of FADS2 (rs1535) modifies therapeutic response of O-3FA in post-AMI cardiac remodeling in 312 patients. Fatty Acids, Omega-3 123-128 fatty acid desaturase 2 Homo sapiens 75-80 31532795-8 2019 CONCLUSION: Genetic profiling using FADS2 genotype can predict the therapeutic benefits of O-3FA treatment against adverse cardiac remodeling during the convalescent phase of AMI. Fatty Acids, Omega-3 91-96 fatty acid desaturase 2 Homo sapiens 36-41 31488809-2 2019 Trials testing the effect of vitamin D or omega-3 polyunsaturated fatty acid (n3-PUFA) supplementation on major depressive disorder (MDD) reported conflicting findings. Fatty Acids, Omega-3 42-76 pumilio RNA binding family member 3 Homo sapiens 81-85 30908893-1 2019 OBJECTIVE: To determine the relationship between omega-3 polyunsaturated fatty acid (n-3 PUFA) consumption (dietary or supplemental) and risk of gout flares. Fatty Acids, Omega-3 49-83 pumilio RNA binding family member 3 Homo sapiens 89-93 31478478-1 2019 Objective: To assess the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on bone metabolism in HIV-infected patients presenting with hypertriglyceridemia. Fatty Acids, Omega-3 35-70 pumilio RNA binding family member 3 Homo sapiens 76-80 30234553-3 2019 In the present study, we quantified the dose-dependent synergistic properties of dietary n-3 polyunsaturated fatty acids (PUFA) and curcumin (Cur) to promote targeted apoptotic deletion of damaged colonic Lgr5 stem cells. Fatty Acids, Omega-3 89-120 leucine rich repeat containing G protein-coupled receptor 5 Homo sapiens 205-209 30803749-9 2019 The magnitude of increase in serum IL-18 (DeltaIL-18) was significantly less in participants in the omega3FA treatment group compared to placebo (P = .047). Fatty Acids, Omega-3 100-108 interleukin 18 Homo sapiens 35-40 30803749-10 2019 CONCLUSION(S): This study has shown that 4 g daily omega3FA supplementation may lower serum IL-18 levels in patients with moderate CKD. Fatty Acids, Omega-3 51-59 interleukin 18 Homo sapiens 92-97 30803749-0 2019 The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patients. Fatty Acids, Omega-3 15-33 interleukin 18 Homo sapiens 74-88 31098654-0 2019 An increase in plasma brain derived neurotrophic factor levels is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: secondary outcome analysis of the OFFER randomized clinical trial. Fatty Acids, Omega-3 77-107 brain derived neurotrophic factor Homo sapiens 22-55 31202891-0 2019 Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA). Fatty Acids, Omega-3 89-107 cAMP responsive element binding protein 1 Homo sapiens 22-26 31098654-1 2019 RATIONALE: N-3 polyunsaturated fatty acids (n-3 PUFA) influence multiple biochemical mechanisms postulated in the pathogenesis of schizophrenia that may influence BDNF synthesis. Fatty Acids, Omega-3 11-42 pumilio RNA binding family member 3 Homo sapiens 48-52 31098654-1 2019 RATIONALE: N-3 polyunsaturated fatty acids (n-3 PUFA) influence multiple biochemical mechanisms postulated in the pathogenesis of schizophrenia that may influence BDNF synthesis. Fatty Acids, Omega-3 11-42 brain derived neurotrophic factor Homo sapiens 163-167 30597013-11 2019 Introduction of the Caenorhabditis elegans Fat1 transgene, leading to an endogenous omega-3 fatty acid synthesis and hence increased substrate for resolvin E1 formation, significantly diminished the differences in phosphate-induced calcification between ChemR23+/+ and ChemR23-/- mice. Fatty Acids, Omega-3 84-102 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 43-47 31543828-0 2019 The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake? Fatty Acids, Omega-3 28-59 pumilio RNA binding family member 3 Homo sapiens 65-69 31192682-3 2019 In this work, omega-3 polyunsaturated fatty acids (PUFA Omega-3) were administered as they have been reported to modulate some molecular pathways such as nuclear factor-kappa B (NF-kappaB), which is associated with toxicity secondary to the administration of anthracyclines. Fatty Acids, Omega-3 14-49 pumilio RNA binding family member 3 Homo sapiens 51-55 31192682-3 2019 In this work, omega-3 polyunsaturated fatty acids (PUFA Omega-3) were administered as they have been reported to modulate some molecular pathways such as nuclear factor-kappa B (NF-kappaB), which is associated with toxicity secondary to the administration of anthracyclines. Fatty Acids, Omega-3 14-49 nuclear factor kappa B subunit 1 Homo sapiens 154-176 31192682-3 2019 In this work, omega-3 polyunsaturated fatty acids (PUFA Omega-3) were administered as they have been reported to modulate some molecular pathways such as nuclear factor-kappa B (NF-kappaB), which is associated with toxicity secondary to the administration of anthracyclines. Fatty Acids, Omega-3 14-49 nuclear factor kappa B subunit 1 Homo sapiens 178-187 31192682-3 2019 In this work, omega-3 polyunsaturated fatty acids (PUFA Omega-3) were administered as they have been reported to modulate some molecular pathways such as nuclear factor-kappa B (NF-kappaB), which is associated with toxicity secondary to the administration of anthracyclines. Fatty Acids, Omega-3 56-63 pumilio RNA binding family member 3 Homo sapiens 51-55 31192682-3 2019 In this work, omega-3 polyunsaturated fatty acids (PUFA Omega-3) were administered as they have been reported to modulate some molecular pathways such as nuclear factor-kappa B (NF-kappaB), which is associated with toxicity secondary to the administration of anthracyclines. Fatty Acids, Omega-3 56-63 nuclear factor kappa B subunit 1 Homo sapiens 154-176 31192682-3 2019 In this work, omega-3 polyunsaturated fatty acids (PUFA Omega-3) were administered as they have been reported to modulate some molecular pathways such as nuclear factor-kappa B (NF-kappaB), which is associated with toxicity secondary to the administration of anthracyclines. Fatty Acids, Omega-3 56-63 nuclear factor kappa B subunit 1 Homo sapiens 178-187 31192682-10 2019 Within the Edmonton scale, xerostomia presented a significant improvement (p = 0.032) in patients supplemented with PUFA Omega-3. Fatty Acids, Omega-3 121-128 pumilio RNA binding family member 3 Homo sapiens 116-120 31225705-5 2019 Omega-3 fatty acid supplementation decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels by >50%. Fatty Acids, Omega-3 0-18 tumor necrosis factor Rattus norvegicus 45-72 31225705-5 2019 Omega-3 fatty acid supplementation decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels by >50%. Fatty Acids, Omega-3 0-18 tumor necrosis factor Rattus norvegicus 74-83 31225705-5 2019 Omega-3 fatty acid supplementation decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels by >50%. Fatty Acids, Omega-3 0-18 interleukin 6 Rattus norvegicus 89-102 31225705-5 2019 Omega-3 fatty acid supplementation decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels by >50%. Fatty Acids, Omega-3 0-18 interleukin 6 Rattus norvegicus 104-108 31225705-8 2019 Omega-3 fatty acid supplementation decreased p53, caspase-3, bax, and pro-NGF mRNA expression by >40%, while the level of bcl-2 mRNA expression was increased by 286.9%. Fatty Acids, Omega-3 0-18 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 45-48 31225705-8 2019 Omega-3 fatty acid supplementation decreased p53, caspase-3, bax, and pro-NGF mRNA expression by >40%, while the level of bcl-2 mRNA expression was increased by 286.9%. Fatty Acids, Omega-3 0-18 caspase 3 Rattus norvegicus 50-59 31225705-8 2019 Omega-3 fatty acid supplementation decreased p53, caspase-3, bax, and pro-NGF mRNA expression by >40%, while the level of bcl-2 mRNA expression was increased by 286.9%. Fatty Acids, Omega-3 0-18 BCL2 associated X, apoptosis regulator Rattus norvegicus 61-64 31225705-9 2019 Omega-3 fatty acid supplementation decreased caspase-3 and p53 protein expression by >30%. Fatty Acids, Omega-3 0-18 caspase 3 Rattus norvegicus 45-54 31225705-9 2019 Omega-3 fatty acid supplementation decreased caspase-3 and p53 protein expression by >30%. Fatty Acids, Omega-3 0-18 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 59-62 31067438-4 2019 While there are many discrepancies in the literature, evidence from both bench and clinical research demonstrate important effects of n-3 polyunsaturated fatty acids (n-3 PUFA), eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA), toward IHD. Fatty Acids, Omega-3 134-165 pumilio RNA binding family member 3 Homo sapiens 171-175 31380384-2 2019 Dietary omega-3 polyunsaturated fatty acids (n-3PUFA) exhibit a protective effect on the loss of muscle tissue during catabolic situations such as injury-simulated leg immobilization. Fatty Acids, Omega-3 8-43 pumilio RNA binding family member 3 Homo sapiens 48-52 30097364-13 2019 CONCLUSIONS: The use of a nutritional supplement enriched with O3FA is associated with a greater preoperative weight loss, reduced postoperative pain and decreased postoperative levels of C reactive protein. Fatty Acids, Omega-3 63-67 C-reactive protein Homo sapiens 188-206 30949952-4 2019 Importantly, Tyrosinemia patients have deficient Omega-3 fatty acids (n-3 PUFA). Fatty Acids, Omega-3 49-68 pumilio RNA binding family member 3 Homo sapiens 74-78 32489952-1 2019 Docosahexaenoic acid (DHA), the most abundant n-3 polyunsaturated fatty acid (n-3PUFA) in the brain, has attracted great importance for a variety of neuronal functions such as signal transduction through plasma membranes, neuronal plasticity, and neuroprotection. Fatty Acids, Omega-3 46-76 pumilio RNA binding family member 3 Homo sapiens 81-85 31346865-3 2019 Intensification of LPO against the background of suppressed activity of antioxidant enzymes and reduced level of omega3 fatty acids attested to the development of oxidative stress. Fatty Acids, Omega-3 113-131 lactoperoxidase Rattus norvegicus 19-22 31029017-11 2019 The elimination of differences between TG and WT mice by an omega3-deficient diet suggests that mechanisms regulating PSD-95 expression and the oxidative degradation of ARA are related and that the timing of dietary omega3 intake during development may influence Alzheimer"s disease-related pathological changes later in life. Fatty Acids, Omega-3 60-66 discs large MAGUK scaffold protein 4 Mus musculus 118-124 31013477-1 2019 Beneficial effects of n-3 polyunsaturated fatty acid (PUFA) supplementation on dairy cow reproduction have been previously reported. Fatty Acids, Omega-3 22-52 PUFA Bos taurus 54-58 31122230-0 2019 Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD. Fatty Acids, Omega-3 0-18 COPD Homo sapiens 84-88 30998938-9 2019 Omega-3 fatty acids also prevented the decreases in hippocampal GPx, catalase and GSH/GSSG ratio and normalized the increases in GSSG levels, which were impaired by SD model. Fatty Acids, Omega-3 0-19 catalase Rattus norvegicus 69-77 30010011-3 2019 The great variety of phospholipase A2s, their differential substrate selectivity under a variety of pathophysiological conditions, as well as the different compartmentalization of each enzyme and accessibility to substrate, render this class of enzymes also key to membrane phospholipid remodeling reactions, and the generation of specific lipid mediators not related with canonical metabolites of omega-6 or omega-3 fatty acids. Fatty Acids, Omega-3 409-428 phospholipase A2 group IB Homo sapiens 21-37 31005316-3 2019 Chia seed has been reported to contain abundant phenolic compounds, dietary fiber, and n-3 fatty acids and therefore is a potential functional food additive. Fatty Acids, Omega-3 87-102 chitinase acidic Homo sapiens 0-4 31142011-3 2019 Various physiological activities of omega-3 fatty acids are due to their agonistic actions on G-protein-coupled receptor 40 (GPR40) and GPR120. Fatty Acids, Omega-3 36-55 free fatty acid receptor 1 Mus musculus 94-123 31138879-2 2019 Whereas animal studies revealed that n-3 polyunsaturated fatty acids (PUFAs) may be of benefit in preventing ROP, human studies conducted on preterm infants during the 1st weeks of life showed no association between blood n-3 PUFA bioavailability and ROP incidence and/or severity, probably because of the influence of nutrition on the lipid status of infants. Fatty Acids, Omega-3 37-68 pumilio RNA binding family member 3 Homo sapiens 70-74 31242648-0 2019 Omega-3 Fatty Acids-Enriched Fish Oil Activates AMPK/PGC-1alpha Signaling and Prevents Obesity-Related Skeletal Muscle Wasting. Fatty Acids, Omega-3 0-19 PPARG coactivator 1 alpha Rattus norvegicus 53-63 30836143-0 2019 Omega-3 fatty acids and docosahexaenoic acid oxymetabolites modulate the inflammatory response of equine recombinant interleukin1beta-stimulated equine synoviocytes. Fatty Acids, Omega-3 0-19 interleukin-1 beta Equus caballus 117-133 30836143-4 2019 We hypothesized that n-3 PUFA and selected docosanoids would modulate inflammatory mediator gene expression by recombinant equine (re)IL-1beta-stimulated synovial fibroblasts. Fatty Acids, Omega-3 21-29 interleukin 1 alpha Equus caballus 134-142 31142011-3 2019 Various physiological activities of omega-3 fatty acids are due to their agonistic actions on G-protein-coupled receptor 40 (GPR40) and GPR120. Fatty Acids, Omega-3 36-55 free fatty acid receptor 1 Mus musculus 125-130 31142011-3 2019 Various physiological activities of omega-3 fatty acids are due to their agonistic actions on G-protein-coupled receptor 40 (GPR40) and GPR120. Fatty Acids, Omega-3 36-55 free fatty acid receptor 4 Mus musculus 136-142 31128594-2 2019 Flaxseed is rich in omega-3 fatty acids (OM3FA), mostly alpha-Linoleic acid (ALA), which gets converted to Docosahexaenoic acid (DHA) by the action of delta-6 desaturase enzyme. Fatty Acids, Omega-3 20-39 fatty acid desaturase 2 Gallus gallus 151-169 31128594-2 2019 Flaxseed is rich in omega-3 fatty acids (OM3FA), mostly alpha-Linoleic acid (ALA), which gets converted to Docosahexaenoic acid (DHA) by the action of delta-6 desaturase enzyme. Fatty Acids, Omega-3 41-46 fatty acid desaturase 2 Gallus gallus 151-169 30941600-0 2019 N-3 Polyunsaturated Fatty Acids and Atrial Fibrillation: Friend or Foe? Fatty Acids, Omega-3 0-31 WAPL cohesin release factor Homo sapiens 67-70 31198496-10 2019 Conclusions: In conclusion, we found that omega-3 fatty acid administration for 12 weeks to subjects with EH significantly improved FPG, insulin, HOMA-IR, TAC and GSH levels, but did not influence regression, lipid profiles, and other biomarkers of inflammatory and oxidative stress. Fatty Acids, Omega-3 42-60 insulin Homo sapiens 137-144 30678465-3 2019 The rs59439148 ALOX5 polymorphism affects leukotriene production and possibly inflammatory responses to n3PUFA. Fatty Acids, Omega-3 104-110 arachidonate 5-lipoxygenase Homo sapiens 15-20 31043161-10 2019 CONCLUSIONS: In summary, this study has demonstrated for the first time that PS, omega-3 fatty acids or the combination thereof significantly improved inflammation, insulin resistance, as well as glucose and lipid metabolism in IGR individuals. Fatty Acids, Omega-3 81-100 insulin Homo sapiens 165-172 31003520-1 2019 While studies revealed that the omega-3 polyunsaturated fatty acids (n-3 PUFA) and their mediators would be able to regulate several biological processes involved into the development of postpartum depression (PPD), evidence from observational studies remains mixed. Fatty Acids, Omega-3 32-67 pumilio RNA binding family member 3 Homo sapiens 73-77 31003450-6 2019 A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Fatty Acids, Omega-3 65-100 pumilio RNA binding family member 3 Homo sapiens 106-110 30293230-10 2019 CONCLUSIONS: The combination of hydroxytyrosol, omega-3 fatty acids, and curcumin reduced inflammation as indicated by a reduction in CRP and reduced pain in patients with aromatase-induced musculoskeletal symptoms. Fatty Acids, Omega-3 48-67 C-reactive protein Homo sapiens 134-137 30735073-1 2019 Supplementation with monounsaturated or omega-3 polyunsaturated fatty acids ( n-3 PUFA) can lower resting blood pressure (BP) and reduce the risk of cardiovascular events. Fatty Acids, Omega-3 40-75 pumilio RNA binding family member 3 Homo sapiens 82-86 30632684-6 2019 CONCLUSION: Intake of a high-fat diet rich in omega-3 fatty acids protects both wild-type and UCP1-deficient mice from obesity and insulin resistance by increasing energy expenditure through unknown mechanisms. Fatty Acids, Omega-3 46-65 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 94-98 30446908-0 2019 Obesity-associated alterations in cardiac connexin-43 and PKC signaling are attenuated by melatonin and omega-3 fatty acids in female rats. Fatty Acids, Omega-3 104-123 gap junction protein, alpha 1 Rattus norvegicus 42-53 30446908-5 2019 There was a clear benefit of melatonin or omega-3 PUFA supplementation due to their antiarrhythmic effects associated with the attenuation of myocardial Cx43, PKC, and miR-30a abnormalities as well as adiposity. Fatty Acids, Omega-3 42-49 gap junction protein, alpha 1 Rattus norvegicus 153-157 30446908-5 2019 There was a clear benefit of melatonin or omega-3 PUFA supplementation due to their antiarrhythmic effects associated with the attenuation of myocardial Cx43, PKC, and miR-30a abnormalities as well as adiposity. Fatty Acids, Omega-3 42-49 microRNA 30a Rattus norvegicus 168-175 30293230-3 2019 We evaluated whether the olive-derived polyphenol hydroxytyrosol combined with omega-3 fatty acids and curcumin would reduce CRP and musculoskeletal symptoms in breast cancer patients receiving adjuvant hormonal therapies. Fatty Acids, Omega-3 79-98 C-reactive protein Homo sapiens 125-128 30519766-3 2019 Omega-3 fatty acids have a documented role in suppressing TNF-alpha; therefore, we hypothesized that they may be of value in relieving inflammation and improving metabolic disturbance in patients with both schizophrenia and MetS. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 58-67 30519766-9 2019 Along with metabolic improvement, omega-3 fatty acids decreased TNF-alpha levels after 12 weeks of treatment (Fgroup x time = 6.71; df = 1, 66; P = 0.012). Fatty Acids, Omega-3 34-53 tumor necrosis factor Homo sapiens 64-73 30975380-3 2019 Fish oil is rich in omega-3 fatty acids, which are ligands for the G-protein coupled receptor 120 (GPR120), expressed on hepatic Kupffer cells. Fatty Acids, Omega-3 20-39 free fatty acid receptor 4 Mus musculus 99-105 30866565-7 2019 Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-gamma at 1 year. Fatty Acids, Omega-3 0-19 interferon gamma Homo sapiens 82-91 30912414-0 2019 Effects of Omega-3 Supplementation on Ki-67 and VEGF Expression Levels and Clinical Outcomes of Locally AdvancedBreast Cancer Patients Treated with Neoadjuvant CAF Chemotherapy: A Randomized Controlled Trial Report Background: Omega-3 is a polyunsaturated fatty acid with an ability to regulate cell proliferation and apoptosisthrough interaction with inflammatory mediators. Fatty Acids, Omega-3 11-18 vascular endothelial growth factor A Homo sapiens 48-52 30899221-1 2019 The cardioprotective and anti-inflammatory effects of long chain omega-3 polyunsaturated fatty acids (n3 PUFA) are believed to be partly mediated by their oxygenated metabolites (oxylipins). Fatty Acids, Omega-3 65-100 pumilio RNA binding family member 3 Homo sapiens 105-109 31007691-2 2019 Some studies have suggested that n-3 polyunsaturated fatty acid (n-3 PUFA) might have beneficial effects in NAFLD. Fatty Acids, Omega-3 33-63 pumilio RNA binding family member 3 Homo sapiens 69-73 30949128-2 2019 DHA exerts potent anti-inflammatory effects through G protein-coupled receptor 120 (GPR120), which is a functional receptor for n-3 fatty acids. Fatty Acids, Omega-3 128-143 free fatty acid receptor 4 Mus musculus 52-82 30949128-2 2019 DHA exerts potent anti-inflammatory effects through G protein-coupled receptor 120 (GPR120), which is a functional receptor for n-3 fatty acids. Fatty Acids, Omega-3 128-143 free fatty acid receptor 4 Mus musculus 84-90 30677594-2 2019 There is some evidence that supplemental omega-3 dietary polyunsaturated fatty acids (n-3 PUFA) can exert positive effects on fertility. Fatty Acids, Omega-3 41-48 PUFA Bos taurus 90-94 30899805-1 2019 Omega-3 polyunsaturated fatty acids (n-3 PUFA) are linked to a variety of health benefits against human disorders and disease. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 30841603-1 2019 Weaning stress can negatively impact a pig"s performance; dietary supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA) reduces inflammatory stress and promotes nursery pig"s health and growth. Fatty Acids, Omega-3 87-122 Polyunsaturated fatty acid percentage Sus scrofa 128-132 30125457-6 2019 Significant beneficial effects from marine n-3 FA supplementation were, however, seen in secondary endpoints plasma triglycerides, plasma high-sensitivity C-reactive protein, and brachial artery flow-mediated dilation. Fatty Acids, Omega-3 43-49 C-reactive protein Homo sapiens 155-173 30199657-0 2019 Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Fatty Acids, Omega-3 0-19 dipeptidyl peptidase like 10 Homo sapiens 64-69 30841436-5 2019 The lipid peroxidation, GSH, SOD, catalase and Gpx levels recovered to near-normal levels following combined treatment with vancomycin and omega-3 fatty acids. Fatty Acids, Omega-3 139-158 catalase Rattus norvegicus 34-42 30804435-3 2019 Omega-3 treatment increased the number of white blood cell, lymphocytes, and monocytes and decreased tumor necrosis factor (TNF)-alpha production under CTX challenge. Fatty Acids, Omega-3 0-7 tumor necrosis factor Sus scrofa 101-134 33336944-1 2019 The consumption of chia seed (Salvia hispanica L.) has increased in recent years due its high content of omega-3 fatty acids and dietary fiber. Fatty Acids, Omega-3 105-124 chitinase acidic Homo sapiens 19-23 33336944-7 2019 However, eight proteins were specifically related to production and storage of plant lipids, thus explaining the high concentration of lipids in chia seeds (around 30%), especially omega-3 fatty acids (around 20%). Fatty Acids, Omega-3 181-200 chitinase acidic Homo sapiens 145-149 30569599-0 2019 Endogenously Synthesized n-3 Polyunsaturated Fatty Acids in Pregnant fat-1 Mice Decreases Mammary Cancer Risk of Female Offspring by Regulating Expression of Long Noncoding RNAs. Fatty Acids, Omega-3 25-56 FAT atypical cadherin 1 Mus musculus 69-74 30804435-4 2019 In addition, we confirmed that omega-3 decreased the expression of nuclear factor (NF)-kappaB, TNF-alpha, interferon (IFN)-gamma, and interleukin (IL)-8 in peripheral blood mononuclear cells. Fatty Acids, Omega-3 31-38 tumor necrosis factor Sus scrofa 95-104 30804435-4 2019 In addition, we confirmed that omega-3 decreased the expression of nuclear factor (NF)-kappaB, TNF-alpha, interferon (IFN)-gamma, and interleukin (IL)-8 in peripheral blood mononuclear cells. Fatty Acids, Omega-3 31-38 interferon gamma Sus scrofa 106-128 30804435-4 2019 In addition, we confirmed that omega-3 decreased the expression of nuclear factor (NF)-kappaB, TNF-alpha, interferon (IFN)-gamma, and interleukin (IL)-8 in peripheral blood mononuclear cells. Fatty Acids, Omega-3 31-38 C-X-C motif chemokine ligand 8 Sus scrofa 134-152 30804435-5 2019 Additionally, omega-3 alleviated the activities of liver injury markers (alanine transaminase [ALT] and aspartate transaminase [AST]) and modulated oxidative stress markers (superoxide dismutase [SOD], malondialdehyde [MDA], and glutathione peroxidase [GPx]) in the blood serum after the CTX challenge. Fatty Acids, Omega-3 14-21 AST Sus scrofa 128-131 30513433-6 2019 After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Fatty Acids, Omega-3 28-35 retinol binding protein 4 Homo sapiens 116-120 30837829-11 2019 The ratio of arachidonic acid (omega-6 FA) to docosahexaenoic acid (omega-3 FA)-containing PE species was increased at early time points in the hippocampus of injured versus sham mice, and in PS1/APP mice there was a coincidental increase compared to wild type littermates at all time points. Fatty Acids, Omega-3 68-78 presenilin 1 Mus musculus 192-195 30513433-6 2019 After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Fatty Acids, Omega-3 28-35 selectin E Homo sapiens 131-133 30513433-7 2019 Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. Fatty Acids, Omega-3 10-17 selectin E Homo sapiens 87-89 30513433-10 2019 Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents. Fatty Acids, Omega-3 24-31 insulin Homo sapiens 104-111 30511840-0 2019 Lowering Effects of n-3 Fatty Acid Supplements on Blood Pressure by Reducing Plasma Angiotensin II in Inner Mongolia Hypertensive Patients: A Double-Blind Randomized Controlled Trial. Fatty Acids, Omega-3 20-34 angiotensinogen Homo sapiens 84-98 30502680-1 2019 OBJECTIVE: Chia seed oil is the richest source of plant-based omega-3 fatty acid, alpha-linolenic acid, but its potential and mechanisms of action to treat obesity are unclear. Fatty Acids, Omega-3 62-80 chitinase, acidic 1 Mus musculus 11-15 30586310-1 2019 The first total synthesis of a lipid mediator derived from natural omega-3-fatty acid docosahexaenoic acid (DHA), 10 S,17 S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). Fatty Acids, Omega-3 67-85 CD59 molecule (CD59 blood group) Homo sapiens 152-161 30896407-1 2019 There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). Fatty Acids, Omega-3 56-91 pumilio RNA binding family member 3 Homo sapiens 97-101 30554092-0 2019 The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinson"s disease: A randomized, double-blind, placebo-controlled trial. Fatty Acids, Omega-3 15-34 insulin Homo sapiens 112-119 30554092-1 2019 OBJECTIVE: This study was conducted to evaluate the effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression related to inflammation, insulin and lipid in subjects with Parkinson"s disease (PD). Fatty Acids, Omega-3 63-82 insulin Homo sapiens 160-167 30554092-5 2019 RESULTS: After the 12-week intervention, compared with the placebo, omega-3 fatty acids and vitamin E co-supplementation downregulated gene expression of tumor necrosis factor alpha (TNF-alpha) (P = 0.002) in PBMC of subjects with PD. Fatty Acids, Omega-3 68-87 tumor necrosis factor Homo sapiens 154-181 30554092-5 2019 RESULTS: After the 12-week intervention, compared with the placebo, omega-3 fatty acids and vitamin E co-supplementation downregulated gene expression of tumor necrosis factor alpha (TNF-alpha) (P = 0.002) in PBMC of subjects with PD. Fatty Acids, Omega-3 68-87 tumor necrosis factor Homo sapiens 183-192 30554092-6 2019 In addition, omega-3 fatty acids and vitamin E co-supplementation upregulated peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.03), and downregulated oxidized low-density lipoprotein receptor (LDLR) (P = 0.002) in PBMC of subjects with PD compared with the placebo. Fatty Acids, Omega-3 13-32 peroxisome proliferator activated receptor gamma Homo sapiens 78-126 30554092-6 2019 In addition, omega-3 fatty acids and vitamin E co-supplementation upregulated peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.03), and downregulated oxidized low-density lipoprotein receptor (LDLR) (P = 0.002) in PBMC of subjects with PD compared with the placebo. Fatty Acids, Omega-3 13-32 peroxisome proliferator activated receptor gamma Homo sapiens 128-138 30554092-6 2019 In addition, omega-3 fatty acids and vitamin E co-supplementation upregulated peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.03), and downregulated oxidized low-density lipoprotein receptor (LDLR) (P = 0.002) in PBMC of subjects with PD compared with the placebo. Fatty Acids, Omega-3 13-32 low density lipoprotein receptor Homo sapiens 213-217 30554092-8 2019 CONCLUSIONS: Overall, omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PD patients significantly improved gene expression of TNF-alpha, PPAR-gamma and LDLR, but did not affect IL-1 and IL-8. Fatty Acids, Omega-3 22-41 tumor necrosis factor Homo sapiens 145-154 30554092-8 2019 CONCLUSIONS: Overall, omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PD patients significantly improved gene expression of TNF-alpha, PPAR-gamma and LDLR, but did not affect IL-1 and IL-8. Fatty Acids, Omega-3 22-41 peroxisome proliferator activated receptor gamma Homo sapiens 156-166 30554092-8 2019 CONCLUSIONS: Overall, omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PD patients significantly improved gene expression of TNF-alpha, PPAR-gamma and LDLR, but did not affect IL-1 and IL-8. Fatty Acids, Omega-3 22-41 low density lipoprotein receptor Homo sapiens 171-175 30760195-0 2019 The Neuromodulatory Effects of omega-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms. Fatty Acids, Omega-3 31-50 mitochondrially encoded cytochrome c oxidase II Homo sapiens 76-81 30760195-0 2019 The Neuromodulatory Effects of omega-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms. Fatty Acids, Omega-3 31-50 nitric oxide synthase 2 Homo sapiens 83-87 30760195-4 2019 Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels. Fatty Acids, Omega-3 0-20 mitochondrially encoded cytochrome c oxidase II Homo sapiens 177-182 30760195-4 2019 Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels. Fatty Acids, Omega-3 0-20 nitric oxide synthase 2 Homo sapiens 187-191 30760195-9 2019 RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels. Fatty Acids, Omega-3 54-73 mitochondrially encoded cytochrome c oxidase II Homo sapiens 152-157 30760195-9 2019 RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels. Fatty Acids, Omega-3 54-73 nitric oxide synthase 2 Homo sapiens 158-162 30367533-5 2019 We observed reduced concentrations of glutamate receptor subunits, including GluA1, GluA2 and NR2B, and synaptic vesicle proteins synaptophysin and synaptotagmin 1 in hippocampal synaptosomes of omega-3 fatty acid-deficient mice as compared to the omega-3 fatty acid rich group. Fatty Acids, Omega-3 195-213 synaptotagmin I Mus musculus 148-163 31332998-8 2019 Comparison between omega-3 fatty acids and sublingual immunotherapy as regards ACT, PEFR, and FEV1and IL17A showed that omega-3 fatty acids treatment was better than sublingual immunotherapy in decreasing IL17A, but both were effective in decreasing PEFR, FEV1 and ACT. Fatty Acids, Omega-3 120-139 interleukin 17A Homo sapiens 205-210 31454802-0 2019 Four-Week Omega-3 Supplementation in Carriers of the Prosteatotic PNPLA3 p.I148M Genetic Variant: An Open-Label Study. Fatty Acids, Omega-3 10-17 patatin like phospholipase domain containing 3 Homo sapiens 66-72 31543373-0 2019 Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function. Fatty Acids, Omega-3 19-38 low density lipoprotein receptor Homo sapiens 53-82 30321297-6 2019 Therefore, in this narrative review, we discuss how omega-3 fatty acid intake and physical activity may modify the impact of ApoE e4 on AD and CVD risk. Fatty Acids, Omega-3 52-70 apolipoprotein E Homo sapiens 125-129 30958356-6 2019 RESULTS: We found significant interactions between omega3-FA supplementation and tHcy on cognition and clinical stage assessed by MMSE (p = 0.040), global CDR (p = 0.059), and CDRsob (p = 0.023), but not on ADAS-cog (p = 0.649). Fatty Acids, Omega-3 51-60 alkylglycerone phosphate synthase Homo sapiens 207-211 30202902-0 2019 Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer. Fatty Acids, Omega-3 41-59 free fatty acid receptor 4 Mus musculus 13-19 30202902-1 2019 Background: GPR120, a G protein-coupled receptor for long-chain polyunsaturated fatty acids (FAs), mediates the anti-inflammatory effects of omega-3 (omega-3) FAs. Fatty Acids, Omega-3 141-148 free fatty acid receptor 4 Mus musculus 12-18 30202902-2 2019 We investigated whether host or tumor GPR120 plays a role in the anti-prostate cancer effects of omega-3 FAs. Fatty Acids, Omega-3 97-108 free fatty acid receptor 4 Mus musculus 38-44 30202902-11 2019 Conclusions: Host GPR120 plays a central role in the anti-prostate cancer effects of dietary omega-3 FAs. Fatty Acids, Omega-3 93-104 free fatty acid receptor 4 Mus musculus 18-24 31454802-3 2019 This study aimed to determine whether short-term supplementation with omega-3 fatty acids impacts hepatic steatosis differently in PNPLA3 p.148I wild-type individuals as compared to homozygous carriers of the PNPLA3 p.148M variant. Fatty Acids, Omega-3 70-89 patatin like phospholipase domain containing 3 Homo sapiens 131-137 31454802-13 2019 The nutrigenomic and metabolic effects of omega-3 fatty acids should be investigated further in carriers of the PNPLA3 148M risk variant. Fatty Acids, Omega-3 42-61 patatin like phospholipase domain containing 3 Homo sapiens 112-118 30296616-0 2019 Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson"s disease: The role of glia and NRf2 regulation. Fatty Acids, Omega-3 22-53 NFE2 like bZIP transcription factor 2 Homo sapiens 140-144 30296616-7 2019 Moreover, the n-3 PUFAs administration decreased the astrogliosis and microgliosis, in both the striatum and substantia nigra (SN), with a higher decrease of GFAP+ and Iba-1+ cells for the DHAH treated group. Fatty Acids, Omega-3 14-23 allograft inflammatory factor 1 Homo sapiens 168-173 30671538-3 2018 Recent reviews show that an increased ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing levels of the endocannabinoid signals AEA and 2-AG, overstimulating CB1R and leading to increased caloric intake, reduced metabolic rates, and weight gain. Fatty Acids, Omega-3 58-77 cannabinoid receptor 1 Homo sapiens 189-193 30788452-0 2019 Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose NLRP3 Inflammasome Signaling in Human Obesity. Fatty Acids, Omega-3 17-36 NLR family pyrin domain containing 3 Homo sapiens 54-59 30788452-1 2019 Context: The NRLP3 inflammasome is a multiprotein danger-sensing complex that serves as a critical link between obesity-related adipose inflammation and insulin resistance and has been shown in animal models to be inhibited by fish oil-derived long chain omega-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 255-290 pumilio RNA binding family member 3 Homo sapiens 296-300 30671538-7 2018 Theoretical explanation: We provide for the first time a causative explanation for this paradox, in which rapid and long-lasting downregulation of CB1R following acute Cannabis consumption reduces energy storage and increases metabolic rates, thus reversing the impact on body mass index of elevated dietary omega-6/omega-3 ratios. Fatty Acids, Omega-3 316-323 cannabinoid receptor 1 Homo sapiens 147-151 30138808-1 2018 OBJECTIVE: The aim of this study is to systematically review the efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplements in reducing depressive symptoms among older adults aged 60 and above. Fatty Acids, Omega-3 77-111 pumilio RNA binding family member 3 Homo sapiens 117-121 30184109-0 2018 An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis. Fatty Acids, Omega-3 3-10 chemokine (C-X-C motif) receptor 4 Mus musculus 76-81 30660136-1 2018 OBJECTIVE: The marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) exert numerous beneficial effects on health, but their potency to defend against development of peripheral insulin resistance of healthy person with overweight remains poorly characterized. Fatty Acids, Omega-3 22-37 insulin Homo sapiens 204-211 30403782-5 2018 Fat-1 mice constitutively express the fat-1 transgene, allowing the conversion of omega-6 to omega-3 fatty acids to yield an optimal tissue ratio of omega-6 to omega-3 fatty acids (~1:1). Fatty Acids, Omega-3 93-112 FAT atypical cadherin 1 Mus musculus 0-5 30403782-5 2018 Fat-1 mice constitutively express the fat-1 transgene, allowing the conversion of omega-6 to omega-3 fatty acids to yield an optimal tissue ratio of omega-6 to omega-3 fatty acids (~1:1). Fatty Acids, Omega-3 93-112 FAT atypical cadherin 1 Mus musculus 38-43 30403782-5 2018 Fat-1 mice constitutively express the fat-1 transgene, allowing the conversion of omega-6 to omega-3 fatty acids to yield an optimal tissue ratio of omega-6 to omega-3 fatty acids (~1:1). Fatty Acids, Omega-3 160-179 FAT atypical cadherin 1 Mus musculus 0-5 30403782-5 2018 Fat-1 mice constitutively express the fat-1 transgene, allowing the conversion of omega-6 to omega-3 fatty acids to yield an optimal tissue ratio of omega-6 to omega-3 fatty acids (~1:1). Fatty Acids, Omega-3 160-179 FAT atypical cadherin 1 Mus musculus 38-43 30515096-2 2018 Since omega-3 fatty acids reduce intimal hyperplasia, we hypothesized that the G protein-coupled receptor ChemR23 for the omega-3-derived pro-resolving lipid mediator resolvin E1 drives those effects. Fatty Acids, Omega-3 6-25 chemokine-like receptor 1 Mus musculus 106-113 30102930-6 2018 These studies indicate that n-3 PUFAs (both eicosapentaenoic acid and docosahexaenoic acid) can decrease the expression of key adhesion molecules, such as vascular cell adhesion molecule 1, by ECs and that this results in decreased adhesive interactions between leukocytes and ECs. Fatty Acids, Omega-3 28-37 vascular cell adhesion molecule 1 Homo sapiens 155-188 30527263-2 2018 We hypothesized that completing a 12-week omega-3 supplementation period along with whole body resistance exercise (3 times/wk) would result in a significantly greater improvement in lean tissue mass as well as a significant decrease in interleukin-6 and tumor necrosis factor-alpha when compared to placebo. Fatty Acids, Omega-3 42-49 interleukin 6 Homo sapiens 237-282 30054952-9 2018 Furthermore, a positive correlation (p < 0.01) was observed between inclusion of omega-3 in cryopreservation medium and each of post-thaw total sperm motility, progressive motility, live sperm, normal sperm, intact acrosome, intact cell membrane, VCL, VSL, VAP, ALH and STR (r = 0.76, 0.84, 0.79, 0.90, 0.89, 0.91, 0.61, 0.73, 0.65, 0.78 and 0.60, respectively). Fatty Acids, Omega-3 84-91 vinculin Ovis aries 250-253 29544992-3 2018 Several biological mechanisms have been identified that support this hypothesis; notably, it has been shown that long chain omega-3 fatty acids have a beneficial effect: a) on bioactive metabolites involved in inflammatory pathways, and b) on alteration of nuclear transcription factor activities such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), involved in inflammatory pathways and liver lipid metabolism. Fatty Acids, Omega-3 124-143 sterol regulatory element binding transcription factor 1 Homo sapiens 358-402 29544992-3 2018 Several biological mechanisms have been identified that support this hypothesis; notably, it has been shown that long chain omega-3 fatty acids have a beneficial effect: a) on bioactive metabolites involved in inflammatory pathways, and b) on alteration of nuclear transcription factor activities such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), involved in inflammatory pathways and liver lipid metabolism. Fatty Acids, Omega-3 124-143 sterol regulatory element binding transcription factor 1 Homo sapiens 404-412 29544992-3 2018 Several biological mechanisms have been identified that support this hypothesis; notably, it has been shown that long chain omega-3 fatty acids have a beneficial effect: a) on bioactive metabolites involved in inflammatory pathways, and b) on alteration of nuclear transcription factor activities such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), involved in inflammatory pathways and liver lipid metabolism. Fatty Acids, Omega-3 124-143 MLX interacting protein like Homo sapiens 418-465 29544992-3 2018 Several biological mechanisms have been identified that support this hypothesis; notably, it has been shown that long chain omega-3 fatty acids have a beneficial effect: a) on bioactive metabolites involved in inflammatory pathways, and b) on alteration of nuclear transcription factor activities such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), involved in inflammatory pathways and liver lipid metabolism. Fatty Acids, Omega-3 124-143 MLX interacting protein like Homo sapiens 467-473 29627343-8 2018 This can occur directly through incorporation of membrane substrates, such as fatty acids, e.g., n-3 polyunsaturated fatty acids (n-3 PUFA) and cholesterol. Fatty Acids, Omega-3 97-128 pumilio RNA binding family member 3 Homo sapiens 134-138 30471768-0 2018 Higher baseline expression of the PTGS2 gene and greater decreases in total colonic fatty acid content predict greater decreases in colonic prostaglandin-E2 concentrations after dietary supplementation with omega-3 fatty acids. Fatty Acids, Omega-3 207-226 prostaglandin-endoperoxide synthase 2 Homo sapiens 34-39 30515096-2 2018 Since omega-3 fatty acids reduce intimal hyperplasia, we hypothesized that the G protein-coupled receptor ChemR23 for the omega-3-derived pro-resolving lipid mediator resolvin E1 drives those effects. Fatty Acids, Omega-3 6-13 chemokine-like receptor 1 Mus musculus 106-113 30515096-3 2018 ChemR23+/+ and ChemR23-/- mice were generated with or without introduction of the Caenorhabditis elegans fat-1 transgene, which leads to an endogenous omega-3 fatty acid synthesis and thus increasing the substrate for resolvin E1 formation. Fatty Acids, Omega-3 151-169 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 105-110 30298620-10 2018 Catalase, Gpx, and SOD were increased in RBMVECs following incubation with omega-3 fatty acids. Fatty Acids, Omega-3 75-94 catalase Rattus norvegicus 0-8 30256492-0 2018 Improvement of insulin resistance via increase of GLUT4 and PPARgamma in metabolic syndrome-induced rats treated with omega-3 fatty acid or l-carnitine. Fatty Acids, Omega-3 118-136 solute carrier family 2 member 4 Rattus norvegicus 50-55 30256492-0 2018 Improvement of insulin resistance via increase of GLUT4 and PPARgamma in metabolic syndrome-induced rats treated with omega-3 fatty acid or l-carnitine. Fatty Acids, Omega-3 118-136 peroxisome proliferator-activated receptor gamma Rattus norvegicus 60-69 30256492-10 2018 CONCLUSION: Omega-3 and l-carnitine improve features of MS via increased GLUT4 and PPARgamma expression. Fatty Acids, Omega-3 12-19 solute carrier family 2 member 4 Rattus norvegicus 73-78 30256492-10 2018 CONCLUSION: Omega-3 and l-carnitine improve features of MS via increased GLUT4 and PPARgamma expression. Fatty Acids, Omega-3 12-19 peroxisome proliferator-activated receptor gamma Rattus norvegicus 83-92 29859385-8 2018 Results of RT-PCR demonstrated that vitamin D and omega-3 fatty acid co-supplementation significantly downregulated gene expression of interleukin-1 (IL-1) (P = 0.03), and upregulated vascular endothelial growth factor (VEGF) (P = 0.004) in PBMCs of subjects with PCOS, when compared with placebo. Fatty Acids, Omega-3 50-68 vascular endothelial growth factor A Homo sapiens 184-218 30197147-7 2018 Increasing the ratio of dietary n-6 to n-3 fatty acids increased mRNA expression of estrogen receptor 1, oxytocin receptor, cyclooxygenase 2, prostaglandin E and F synthases, and steroidogenic acute regulatory protein in endometrium, but decreased expression of peroxisome proliferator-activated receptor gamma and insulin-like growth factor-1. Fatty Acids, Omega-3 39-54 estrogen receptor 1 Bos taurus 84-103 30197147-7 2018 Increasing the ratio of dietary n-6 to n-3 fatty acids increased mRNA expression of estrogen receptor 1, oxytocin receptor, cyclooxygenase 2, prostaglandin E and F synthases, and steroidogenic acute regulatory protein in endometrium, but decreased expression of peroxisome proliferator-activated receptor gamma and insulin-like growth factor-1. Fatty Acids, Omega-3 39-54 prostaglandin-endoperoxide synthase 2 Bos taurus 124-140 30041907-0 2018 A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Delta6-desaturation of omega-3 fatty acids. Fatty Acids, Omega-3 108-127 fatty acid desaturase 2 Homo sapiens 8-13 30041907-0 2018 A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Delta6-desaturation of omega-3 fatty acids. Fatty Acids, Omega-3 108-127 fatty acid desaturase 2 Homo sapiens 70-75 30041907-3 2018 Here we report identification of a novel alternative transcript (AT) of fatty acid desaturase 2 (FADS2) that inhibits production of omega-3 but not omega-6 LCPUFA, discovered during study of ATs in human milk fat globules (MFG). Fatty Acids, Omega-3 132-139 fatty acid desaturase 2 Homo sapiens 72-95 30041907-3 2018 Here we report identification of a novel alternative transcript (AT) of fatty acid desaturase 2 (FADS2) that inhibits production of omega-3 but not omega-6 LCPUFA, discovered during study of ATs in human milk fat globules (MFG). Fatty Acids, Omega-3 132-139 fatty acid desaturase 2 Homo sapiens 97-102 30145885-6 2018 Importantly, the differential depositions of ALA and its long-chain n-3 fatty acids in plasma and ER membranes were observed, concomitant with the rescued ER unfolded protein response and Jun N-terminal kinase (JNK) signaling in mice liver. Fatty Acids, Omega-3 68-83 mitogen-activated protein kinase 8 Mus musculus 188-209 30145885-6 2018 Importantly, the differential depositions of ALA and its long-chain n-3 fatty acids in plasma and ER membranes were observed, concomitant with the rescued ER unfolded protein response and Jun N-terminal kinase (JNK) signaling in mice liver. Fatty Acids, Omega-3 68-83 mitogen-activated protein kinase 8 Mus musculus 211-214 30287519-0 2018 Omega-3 polyunsaturated fatty acids reduce preterm labor by inhibiting trophoblast cathepsin S and inflammasome activation. Fatty Acids, Omega-3 0-35 cathepsin S Homo sapiens 83-94 30333104-1 2018 OBJECTIVE: To determine the longitudinal association between serial biomarker measures of circulating omega 3 polyunsaturated fatty acid (n3-PUFA) levels and healthy ageing. Fatty Acids, Omega-3 102-136 pumilio RNA binding family member 3 Homo sapiens 141-145 29730243-1 2018 Docosahexaenoic acid (DHA, 22:6) is an n-3 polyunsaturated fatty acid (n-3 PUFA) that influences immunological, metabolic, and neurological responses through complex mechanisms. Fatty Acids, Omega-3 39-69 pumilio RNA binding family member 3 Homo sapiens 75-79 29859385-8 2018 Results of RT-PCR demonstrated that vitamin D and omega-3 fatty acid co-supplementation significantly downregulated gene expression of interleukin-1 (IL-1) (P = 0.03), and upregulated vascular endothelial growth factor (VEGF) (P = 0.004) in PBMCs of subjects with PCOS, when compared with placebo. Fatty Acids, Omega-3 50-68 vascular endothelial growth factor A Homo sapiens 220-224 29859385-9 2018 CONCLUSIONS: Overall, the co-administration of vitamin D and omega-3 fatty acid for 12 weeks had beneficial effects on mental health parameters, serum total testosterone, hs-CRP, plasma TAC and MDA levels, and gene expression of IL-1 and VEGF among women with PCOS. Fatty Acids, Omega-3 61-79 vascular endothelial growth factor A Homo sapiens 238-242 30324119-0 2018 The Effect of Omega-3 Fatty Acids on Serum Apelin Levels in Cardiovascular Disease: A Randomized, Double-Blind, Placebo-Controlled Trial. Fatty Acids, Omega-3 14-33 apelin Homo sapiens 43-49 30293593-2 2018 However, the consumption of omega-3 polyunsaturated fatty acid (n-3 PUFA) seems to be protective for this population, improving inhibitory control and behavioral reactivity. Fatty Acids, Omega-3 28-62 pumilio RNA binding family member 3 Homo sapiens 68-72 29981843-2 2018 Several studies have demonstrated the association of comorbid psychiatric conditions with decreased n-3 polyunsaturated fatty acids, which may act as an agonist for GPR40. Fatty Acids, Omega-3 100-131 free fatty acid receptor 1 Mus musculus 165-170 30142422-0 2018 n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation. Fatty Acids, Omega-3 0-31 NFE2 like bZIP transcription factor 2 Homo sapiens 125-129 30324119-4 2018 The aim of this study was to assess the influence of omega-3 fatty acids supplementation on the serum apelin levels in patients with cardiovascular disease. Fatty Acids, Omega-3 53-72 apelin Homo sapiens 102-108 30324119-13 2018 Compared to placebo, the intake of omega-3 fatty acids increased serum apelin levels (p= 0.018), decreased the levels of LDL cholesterol, and decreased serum hs-CRP concentrations (p= 0.007, p= 0.011 respectively). Fatty Acids, Omega-3 35-54 apelin Homo sapiens 71-77 30324119-15 2018 Conclusion: Omega-3 fatty acid supplementation increases serum apelin and HDL concentrations, while decreasing serum LDL-C and hs-CRP levels. Fatty Acids, Omega-3 12-30 apelin Homo sapiens 63-69 28981381-0 2018 Effects of n-3 Polyunsaturated Fatty Acid Supplementation on Serum Leptin Levels, Appetite Sensations, and Intake of Energy and Macronutrients in Obese People: A Randomized Clinical Trial. Fatty Acids, Omega-3 11-41 leptin Homo sapiens 67-73 30230402-5 2018 RESULTS: Compared with the placebo, omega-3 fatty acid intake led to a significant improvement in Beck Depression Inventory [beta (difference in the mean outcomes measures between treatment groups after intervention) -1.05; 95% CI: -1.84, -0.26; p = .01], general health questionnaire (beta -1.68; 95% CI: -3.12, -0.24; p = .02) and depression anxiety and stress scale (beta -2.03; 95% CI: -3.60, -0.46; p = .01). Fatty Acids, Omega-3 36-54 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 370-377 30213082-0 2018 Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway. Fatty Acids, Omega-3 0-19 AKT serine/threonine kinase 1 Homo sapiens 82-85 30254287-0 2018 Omega-3 from Flaxseed Oil Protects Obese Mice Against Diabetic Retinopathy Through GPR120 Receptor. Fatty Acids, Omega-3 0-7 free fatty acid receptor 4 Mus musculus 83-89 29397560-9 2018 Moreover, n-3 fatty acids (FAs) ingested as phospholipids increase BDNF levels favoring an improvement in energy state within neurons and facilitating both mitochondrial and protein synthesis, which are necessary for synaptic plasticity. Fatty Acids, Omega-3 10-25 brain-derived neurotrophic factor Rattus norvegicus 67-71 30181696-6 2018 Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines (IL-1beta, IL-2, and TNFalpha), whereas canagliflozin and omega-3 fatty acid combination has reduced these biochemical parameters significantly when compared with diabetic group. Fatty Acids, Omega-3 40-58 interleukin 1 beta Rattus norvegicus 148-156 30181696-6 2018 Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines (IL-1beta, IL-2, and TNFalpha), whereas canagliflozin and omega-3 fatty acid combination has reduced these biochemical parameters significantly when compared with diabetic group. Fatty Acids, Omega-3 40-58 interleukin 2 Rattus norvegicus 158-162 30181696-6 2018 Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines (IL-1beta, IL-2, and TNFalpha), whereas canagliflozin and omega-3 fatty acid combination has reduced these biochemical parameters significantly when compared with diabetic group. Fatty Acids, Omega-3 40-58 tumor necrosis factor Rattus norvegicus 168-176 30212928-0 2018 Effect of omega 3 fatty acids on C-reactive protein and interleukin-6 in patients with advanced nonsmall cell lung cancer. Fatty Acids, Omega-3 10-29 C-reactive protein Homo sapiens 33-51 30212928-0 2018 Effect of omega 3 fatty acids on C-reactive protein and interleukin-6 in patients with advanced nonsmall cell lung cancer. Fatty Acids, Omega-3 10-29 interleukin 6 Homo sapiens 56-69 30115829-3 2018 Among nutrients, high-quality protein, leucine, vitamin D, and omega-3 polyunsaturated fatty acids (n-3 PUFA) are of particular interest for their demonstrated effects on skeletal muscle health. Fatty Acids, Omega-3 63-98 pumilio RNA binding family member 3 Homo sapiens 104-108 28716464-0 2018 Modulating effects of omega-3 fatty acids and pioglitazone combination on insulin resistance through toll-like receptor 4 in type 2 diabetes mellitus. Fatty Acids, Omega-3 22-41 toll-like receptor 4 Rattus norvegicus 101-121 28716464-8 2018 Omega-3 fatty acids and the combination treatment significantly decreased TLR-4 activation. Fatty Acids, Omega-3 0-19 toll-like receptor 4 Rattus norvegicus 74-79 28716464-9 2018 Omega-3 fatty acids, pioglitazone, and their combination significantly decreased TLR-4 mRNA expression, hepatic malondialdehyde, total cholesterol and triglycerides levels, compared to diabetic group. Fatty Acids, Omega-3 0-19 toll-like receptor 4 Rattus norvegicus 81-86 28442236-0 2018 Red blood cell membrane omega-3 fatty acid levels and physical performance: Cross-sectional data from the MAPT study. Fatty Acids, Omega-3 24-42 microtubule associated protein tau Homo sapiens 106-110 29660442-4 2018 Decreased SorLA levels have been correlated to Alzheimer"s disease, and omega-3 fatty acid supplementation is known to increase SorLA expression in neuronal cell lines and mouse models. Fatty Acids, Omega-3 72-90 sortilin-related receptor, LDLR class A repeats-containing Mus musculus 128-133 29660442-7 2018 Lifelong exposure to omega-3 supplementation resulted in impaired spatial learning in Sorl1-/- mice. Fatty Acids, Omega-3 21-28 sortilin-related receptor, LDLR class A repeats-containing Mus musculus 86-91 29982544-9 2018 In addition, omega-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations. Fatty Acids, Omega-3 13-31 insulin Homo sapiens 109-116 29864682-6 2018 Supplementation of n-3 PUFA for 6 months resulted in a significant increase in concentrations of eicosapentaenoic and docosahexaenoic acids in red blood cells along with an attenuation of hepatic steatosis as reflected by the reduction of the FLI, ALT and ALT/AST ratio. Fatty Acids, Omega-3 19-27 solute carrier family 17 member 5 Homo sapiens 260-263 29982544-9 2018 In addition, omega-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations. Fatty Acids, Omega-3 13-31 insulin Homo sapiens 118-125 29982544-9 2018 In addition, omega-3 fatty acid and vitamin D cosupplementation resulted in a significant reduction in serum insulin, insulin resistance, and total/HDL-cholesterol, and a significant increase in insulin sensitivity and serum HDL-cholesterol concentrations. Fatty Acids, Omega-3 13-31 insulin Homo sapiens 118-125 30103934-7 2018 Summarily, while early exposure to TFAs-based diets seems to harm pups" glucose homeostasis, maternal consumption of n - 3 PUFAs can improve lipid metabolism, TAG hepatic accumulation and catalase protein expression in 21-day-old offspring. Fatty Acids, Omega-3 117-128 catalase Rattus norvegicus 188-196 29486268-1 2018 Among environmental factors that may affect on brain function, some nutrients and particularly n-3 polyunsaturated fatty acids (n-3 PUFA) are required for optimal brain development. Fatty Acids, Omega-3 95-126 pumilio RNA binding family member 3 Homo sapiens 132-136 29981570-10 2018 Moreover, n-3PUFAs supplementation was associated with reduction in plasma levels of TNF-alpha [ES: - 0.59 (- 1.17, - 0.01); p = 0.045] and IL-6 (ES: - 1.67 (- 3.14, - 0.20); p = 0.026]. Fatty Acids, Omega-3 10-18 tumor necrosis factor Homo sapiens 85-94 29981570-10 2018 Moreover, n-3PUFAs supplementation was associated with reduction in plasma levels of TNF-alpha [ES: - 0.59 (- 1.17, - 0.01); p = 0.045] and IL-6 (ES: - 1.67 (- 3.14, - 0.20); p = 0.026]. Fatty Acids, Omega-3 10-18 interleukin 6 Homo sapiens 140-144 29453672-11 2018 CONCLUSION: Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes. Fatty Acids, Omega-3 40-49 leptin Homo sapiens 67-73 29453672-11 2018 CONCLUSION: Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes. Fatty Acids, Omega-3 40-49 adiponectin, C1Q and collagen domain containing Homo sapiens 78-89 29453672-11 2018 CONCLUSION: Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes. Fatty Acids, Omega-3 40-49 adiponectin, C1Q and collagen domain containing Homo sapiens 111-122 29453672-11 2018 CONCLUSION: Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes. Fatty Acids, Omega-3 40-49 leptin Homo sapiens 138-144 29856782-0 2018 Long-term dietary (n-3) polyunsaturated fatty acids show benefits to the lungs of Cftr F508del mice. Fatty Acids, Omega-3 18-51 cystic fibrosis transmembrane conductance regulator Mus musculus 82-86 29151396-1 2018 In France, animal products (dairy products, meat and eggs) are the main source of n-3 polyunsaturated fatty acids (PUFA) in the human diet; however, many individuals do not consume enough of this nutrient. Fatty Acids, Omega-3 82-113 Polyunsaturated fatty acid percentage Sus scrofa 115-119 29626526-1 2018 n-3 polyunsaturated fatty acids (n-3 PUFA) might regulate metabolism by lowering endocannabinoid levels. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 37-41 29574938-2 2018 Resolvin E1 (Rv E1 ) is one of these SPM"s derived from the omega-3 fatty acid eicosapentaenoic acid. Fatty Acids, Omega-3 60-78 small nucleolar RNA, H/ACA box 73A Homo sapiens 9-18 30652834-3 2018 Fat-1 mice are able to convert omega-6 fatty acids to omega-3 fatty acids due to gene fat-1 from Caenorhabditis elegans that encodes an omega-3 fatty acids desaturase. Fatty Acids, Omega-3 54-73 FAT atypical cadherin 1 Mus musculus 0-5 30652834-3 2018 Fat-1 mice are able to convert omega-6 fatty acids to omega-3 fatty acids due to gene fat-1 from Caenorhabditis elegans that encodes an omega-3 fatty acids desaturase. Fatty Acids, Omega-3 54-73 FAT atypical cadherin 1 Mus musculus 86-91 30652834-3 2018 Fat-1 mice are able to convert omega-6 fatty acids to omega-3 fatty acids due to gene fat-1 from Caenorhabditis elegans that encodes an omega-3 fatty acids desaturase. Fatty Acids, Omega-3 136-155 FAT atypical cadherin 1 Mus musculus 0-5 30652834-3 2018 Fat-1 mice are able to convert omega-6 fatty acids to omega-3 fatty acids due to gene fat-1 from Caenorhabditis elegans that encodes an omega-3 fatty acids desaturase. Fatty Acids, Omega-3 136-155 FAT atypical cadherin 1 Mus musculus 86-91 29882567-9 2018 Additionally, our results firstly showed the decreased expression of GR in the hippocampus of parous rats that were exposed to Omega-3 PUFA-deficient diets, which may partly facilitate the hyperactivity of the HPA axis and exert detrimental effects. Fatty Acids, Omega-3 127-139 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 69-71 29882567-10 2018 Moreover, the reduction of GR was ameliorated by Omega-3 PUFA supplementation, providing new evidence for Omega-3 PUFAs in the progression of postpartum depression. Fatty Acids, Omega-3 49-61 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 27-29 29882567-10 2018 Moreover, the reduction of GR was ameliorated by Omega-3 PUFA supplementation, providing new evidence for Omega-3 PUFAs in the progression of postpartum depression. Fatty Acids, Omega-3 106-119 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 27-29 29684444-3 2018 We hypothesised that conflicting effects of immunonutrition could be explained by the influence of omega-3 fatty acids on systemic blood pressure or immune effector cells through Slo1. Fatty Acids, Omega-3 99-118 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Mus musculus 179-183 29899324-2 2018 Recently, we reported that fat-1 mice, which can convert n-6 to n-3 polyunsaturated fatty acids (PUFAs), are protected against allergic airway inflammation because their Th2 immune responses are suppressed. Fatty Acids, Omega-3 64-95 FAT atypical cadherin 1 Mus musculus 27-32 29899324-2 2018 Recently, we reported that fat-1 mice, which can convert n-6 to n-3 polyunsaturated fatty acids (PUFAs), are protected against allergic airway inflammation because their Th2 immune responses are suppressed. Fatty Acids, Omega-3 64-95 heart and neural crest derivatives expressed 2 Mus musculus 170-173 28857425-8 2018 The supplementation with MCP and omega-3 fatty acid also managed to reduce the level of IL-6 (P = 0.002). Fatty Acids, Omega-3 33-51 interleukin 6 Homo sapiens 88-92 29563188-1 2018 The fat-1 gene from Caenorhabditis elegans encodes a fatty acid desaturase which was widely studied due to its beneficial function of converting n-6 polyunsaturated fatty acids (n-6PUFAs) to n-3 polyunsaturated fatty acids (n-3PUFAs). Fatty Acids, Omega-3 191-222 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 4-9 29861448-1 2018 Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementations are thought to improve essential fatty acid deficiency (EFAD) as well as reduce inflammation in Cystic Fibrosis (CF), but their effectiveness in clinical studies remains unknown. Fatty Acids, Omega-3 0-34 pumilio RNA binding family member 3 Homo sapiens 40-44 29766165-10 2018 Besides, the changes in FGF21 levels were associated with the changes in EPA, n-3-PUFAs, Delta5/6D, and n-6/n-3 PUFA ratio. Fatty Acids, Omega-3 78-87 fibroblast growth factor 21 Homo sapiens 24-29 29766165-11 2018 Altogether, our study suggests that n-3-PUFAs influence FGF21 levels in obesity, although the specific mechanisms implicated remain to be elucidated. Fatty Acids, Omega-3 36-45 fibroblast growth factor 21 Homo sapiens 56-61 29686092-9 2018 This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids. Fatty Acids, Omega-3 240-259 ectodysplasin A receptor Homo sapiens 40-44 29686092-9 2018 This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids. Fatty Acids, Omega-3 240-259 stearoyl-CoA desaturase Homo sapiens 96-117 29686092-9 2018 This hypothesized selective context for EDAR V370A was likely intertwined with selection on the fatty acid desaturase (FADS) gene cluster because it is known to modulate lipid profiles transmitted to milk from a vitamin D-rich diet high in omega-3 fatty acids. Fatty Acids, Omega-3 240-259 stearoyl-CoA desaturase Homo sapiens 119-123 29563188-1 2018 The fat-1 gene from Caenorhabditis elegans encodes a fatty acid desaturase which was widely studied due to its beneficial function of converting n-6 polyunsaturated fatty acids (n-6PUFAs) to n-3 polyunsaturated fatty acids (n-3PUFAs). Fatty Acids, Omega-3 224-232 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 4-9 29577973-10 2018 Plasma MPO was significantly reduced with n-3 FA alone (P = 0.013) but not when given in combination with CoQ. Fatty Acids, Omega-3 42-48 myeloperoxidase Homo sapiens 7-10 28835131-0 2018 IL-1beta and TNFalpha inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids. Fatty Acids, Omega-3 191-206 interleukin 1 beta Homo sapiens 0-8 28835131-0 2018 IL-1beta and TNFalpha inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids. Fatty Acids, Omega-3 191-206 tumor necrosis factor Homo sapiens 13-21 29577973-11 2018 CONCLUSION: n-3 FA supplementation in patients with CKD leads to increased neutrophil release of LTB5 and several SPM, as well as a reduction in plasma MPO that may have important implications for limiting chronic inflammation. Fatty Acids, Omega-3 12-18 myeloperoxidase Homo sapiens 152-155 29892158-6 2018 Docosahexaenoic acid, an n-3 polyunsaturated fatty acids abundant in the neuronal membrane, was also found to enhance alpha-synuclein oligomerization; however, the precise details of the chemical reaction involved are unclear. Fatty Acids, Omega-3 25-56 synuclein alpha Homo sapiens 118-133 29695082-1 2018 Marine omega-3 polyunsaturated fatty acids (n-3 PUFA) are important nutrients during periods of rapid growth and development in utero and infancy. Fatty Acids, Omega-3 7-42 pumilio RNA binding family member 3 Homo sapiens 48-52 29699561-1 2018 BACKGROUND: Docosahexaenoic acid (DHA) is a n-3 polyunsaturated fatty acid (PUFA) belonging to a family of biologically active fatty acids (FA), which are known to have numerous health benefits. Fatty Acids, Omega-3 44-74 PUFA Bos taurus 76-80 29619114-0 2018 Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells. Fatty Acids, Omega-3 0-18 tumor protein p53 Homo sapiens 33-36 29619114-0 2018 Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells. Fatty Acids, Omega-3 0-18 microRNA 16-1 Homo sapiens 52-65 29619114-0 2018 Omega-3 fatty acid DHA modulates p53, survivin, and microRNA-16-1 expression in KRAS-mutant colorectal cancer stem-like cells. Fatty Acids, Omega-3 0-18 KRAS proto-oncogene, GTPase Homo sapiens 80-84 29452758-1 2018 OBJECTIVE: To study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements. Fatty Acids, Omega-3 102-120 adiponectin, C1Q and collagen domain containing Homo sapiens 27-38 28040302-2 2018 The dietary addition of omega-3 polyunsaturated fatty acids (PUFAs) provides a promising therapy for children with NAFLD due to its convenience and safety; however, several studies suggested contradictory results for PUFA supplementation in children. Fatty Acids, Omega-3 24-59 pumilio RNA binding family member 3 Homo sapiens 61-65 29452758-10 2018 CONCLUSION: Omega-3 fatty acid supplementation for 12weeks caused a significant increase in plasma adiponectin levels in women with polycystic ovary syndrome. Fatty Acids, Omega-3 12-30 adiponectin, C1Q and collagen domain containing Homo sapiens 99-110 29436695-12 2018 These results suggest that exogenous dietary n-3 PUFAs can inhibit mTORC1 signaling and enhance autophagy, promoting functional recovery of rats with SCI. Fatty Acids, Omega-3 45-54 CREB regulated transcription coactivator 1 Mus musculus 67-73 29397217-9 2018 CONCLUSIONS: Supplementation with omega-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF-alpha, IL-6, IL-1beta, and IL-17 but increasing levels of IL-10. Fatty Acids, Omega-3 34-47 tumor necrosis factor Rattus norvegicus 119-128 29397217-9 2018 CONCLUSIONS: Supplementation with omega-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF-alpha, IL-6, IL-1beta, and IL-17 but increasing levels of IL-10. Fatty Acids, Omega-3 34-47 interleukin 6 Rattus norvegicus 130-134 29397217-9 2018 CONCLUSIONS: Supplementation with omega-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF-alpha, IL-6, IL-1beta, and IL-17 but increasing levels of IL-10. Fatty Acids, Omega-3 34-47 interleukin 1 beta Rattus norvegicus 136-144 29397217-9 2018 CONCLUSIONS: Supplementation with omega-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF-alpha, IL-6, IL-1beta, and IL-17 but increasing levels of IL-10. Fatty Acids, Omega-3 34-47 interleukin 17A Rattus norvegicus 150-155 29397217-9 2018 CONCLUSIONS: Supplementation with omega-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF-alpha, IL-6, IL-1beta, and IL-17 but increasing levels of IL-10. Fatty Acids, Omega-3 34-47 interleukin 10 Rattus norvegicus 181-186 29580250-11 2018 CONCLUSION: Based on current evidence, omega-3 fatty acid may be recommended for the treatment of PCOS with insulin resistance as well as high TC (especially LDL-C) and TG. Fatty Acids, Omega-3 39-57 insulin Homo sapiens 108-115 29271576-11 2018 This suggested that there is insufficient evidence to conclude the benefit of omega-3 fatty acids oral supplementation in reducing serum levels of CRP, IL-6 and TNF-alpha in patients with CKD. Fatty Acids, Omega-3 78-97 C-reactive protein Homo sapiens 147-150 29271576-11 2018 This suggested that there is insufficient evidence to conclude the benefit of omega-3 fatty acids oral supplementation in reducing serum levels of CRP, IL-6 and TNF-alpha in patients with CKD. Fatty Acids, Omega-3 78-97 interleukin 6 Homo sapiens 152-156 29271576-11 2018 This suggested that there is insufficient evidence to conclude the benefit of omega-3 fatty acids oral supplementation in reducing serum levels of CRP, IL-6 and TNF-alpha in patients with CKD. Fatty Acids, Omega-3 78-97 tumor necrosis factor Homo sapiens 161-170 29538286-6 2018 Dietary omega 3 polyunsaturated fatty acids (PUFA) have been suggested to counteract insulin resistance development by modulating mitochondrial bioenergetics and ER stress. Fatty Acids, Omega-3 8-15 insulin Homo sapiens 85-92 29543869-7 2018 We used fat-1 transgenic mice expressing the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase that converts n-6 to n-3 fatty acids, leading to abundant n-3 fatty acids without the need of a dietary n-3 supply. Fatty Acids, Omega-3 138-153 FAT atypical cadherin 1 Mus musculus 8-13 29543869-7 2018 We used fat-1 transgenic mice expressing the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase that converts n-6 to n-3 fatty acids, leading to abundant n-3 fatty acids without the need of a dietary n-3 supply. Fatty Acids, Omega-3 138-153 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 68-73 29543869-7 2018 We used fat-1 transgenic mice expressing the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase that converts n-6 to n-3 fatty acids, leading to abundant n-3 fatty acids without the need of a dietary n-3 supply. Fatty Acids, Omega-3 175-190 FAT atypical cadherin 1 Mus musculus 8-13 29543869-7 2018 We used fat-1 transgenic mice expressing the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase that converts n-6 to n-3 fatty acids, leading to abundant n-3 fatty acids without the need of a dietary n-3 supply. Fatty Acids, Omega-3 175-190 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 68-73 29579102-1 2018 A few studies have assessed the association between omega-3 polyunsaturated fatty acids (n-3 PUFA) and cognitive impairment (CI) in very old adults. Fatty Acids, Omega-3 52-87 pumilio RNA binding family member 3 Homo sapiens 93-97 29570616-8 2018 Meta-analyses indicated significant reduction in CRP levels by omega-3 fatty acids (Random model effect: -0.667 mg/L, p < 0.001) and vitamin E (fixed model effect: -0.257 mg/L, p = 0.005). Fatty Acids, Omega-3 63-82 C-reactive protein Homo sapiens 49-52 29306057-6 2018 Compared with the placebo, omega-3 and vitamin E co-supplementation could up-regulate peroxisome proliferator-activated receptor gamma (PPAR-gamma) expression (P = 0.04) in peripheral blood mononuclear cells (PBMC) of PCOS women. Fatty Acids, Omega-3 27-34 peroxisome proliferator activated receptor gamma Homo sapiens 86-134 29306057-6 2018 Compared with the placebo, omega-3 and vitamin E co-supplementation could up-regulate peroxisome proliferator-activated receptor gamma (PPAR-gamma) expression (P = 0.04) in peripheral blood mononuclear cells (PBMC) of PCOS women. Fatty Acids, Omega-3 27-34 peroxisome proliferator activated receptor gamma Homo sapiens 136-146 29306057-7 2018 In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women. Fatty Acids, Omega-3 40-47 C-X-C motif chemokine ligand 8 Homo sapiens 96-109 29306057-7 2018 In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women. Fatty Acids, Omega-3 40-47 C-X-C motif chemokine ligand 8 Homo sapiens 111-115 29306057-7 2018 In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women. Fatty Acids, Omega-3 40-47 tumor necrosis factor Homo sapiens 133-160 29306057-7 2018 In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-alpha) expression (P = 0.001) in PBMC of PCOS women. Fatty Acids, Omega-3 40-47 tumor necrosis factor Homo sapiens 162-171 29306057-9 2018 CONCLUSION: Omega-3 and vitamin E co-supplementation was effective in improving parameters of mental health, and gene expression of PPAR-gamma, IL-8 and TNF-alpha of women with PCOS. Fatty Acids, Omega-3 12-19 peroxisome proliferator activated receptor gamma Homo sapiens 132-142 29306057-9 2018 CONCLUSION: Omega-3 and vitamin E co-supplementation was effective in improving parameters of mental health, and gene expression of PPAR-gamma, IL-8 and TNF-alpha of women with PCOS. Fatty Acids, Omega-3 12-19 C-X-C motif chemokine ligand 8 Homo sapiens 144-148 29306057-9 2018 CONCLUSION: Omega-3 and vitamin E co-supplementation was effective in improving parameters of mental health, and gene expression of PPAR-gamma, IL-8 and TNF-alpha of women with PCOS. Fatty Acids, Omega-3 12-19 tumor necrosis factor Homo sapiens 153-162 29237386-0 2018 The Combined Effects of omega -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients. Fatty Acids, Omega-3 24-44 intercellular adhesion molecule 1 Homo sapiens 82-115 29237386-0 2018 The Combined Effects of omega -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients. Fatty Acids, Omega-3 24-44 intercellular adhesion molecule 1 Homo sapiens 117-123 29237386-3 2018 Curcumin and omega-3 fatty acids, by affecting transcription factors, can regulate the gene expression and serum levels of ICAM-1. Fatty Acids, Omega-3 13-32 intercellular adhesion molecule 1 Homo sapiens 123-129 29237386-4 2018 Thus, this study aimed to evaluate the synergistic effects of omega-3 fatty acids and nano-curcumin on ICAM-1 gene expression and serum levels in migraine patients. Fatty Acids, Omega-3 62-81 intercellular adhesion molecule 1 Homo sapiens 103-109 29237386-10 2018 CONCLUSION: Considering the results of supplementation with omega-3 fatty acids plus curcumin led to reductions of both attack frequency and ICAM-1 serum level in patients, it seems that supplementation with these two nutrients not only can lead to improvements in the function of metabolic pathways, but can also be used effectively as a treatment or prevention of migraine complications. Fatty Acids, Omega-3 60-79 intercellular adhesion molecule 1 Homo sapiens 141-147 29356527-1 2018 Owing to its high omega-3 fatty acid content, milk from grass-fed dairy cows is becoming increasingly more attractive to consumers. Fatty Acids, Omega-3 18-36 Weaning weight-maternal milk Bos taurus 46-50 29552010-2 2018 Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation has been shown to improve endothelial function in a number of diseases; thus, it could be of high clinical relevance in APS. Fatty Acids, Omega-3 0-34 pumilio RNA binding family member 3 Homo sapiens 40-44 29538286-8 2018 Understanding the mechanisms by which omega 3 PUFA modulates cellular metabolism and insulin resistance in peripheral tissues may provide additional details on the potential impact of omega 3 PUFA on metabolic function and the management of insulin resistance in humans. Fatty Acids, Omega-3 38-50 insulin Homo sapiens 241-248 29229294-1 2018 Polyunsaturated fatty acids omega-3 (n-3 PUFA), such as docosahexaenoic acid (DHA), have been shown to prevent, and partially reverse, neurotoxin-induced nigrostriatal denervation in animal models of Parkinson"s disease (PD). Fatty Acids, Omega-3 28-35 pumilio RNA binding family member 3 Homo sapiens 41-45 29367704-4 2018 A 7 years and 10 months old girl affected by PELD was treated at age 3 years with metreleptin, adding at age 6 omega-3 fatty acid supplementation. Fatty Acids, Omega-3 111-129 BSCL2 lipid droplet biogenesis associated, seipin Homo sapiens 45-49 29466282-1 2018 There is evidence that sea buckthorn, as a source of n-3 polyunsaturated fatty acids (n-3 PUFA), possesses health-enhancing properties and may modulate neuroendocrine and immune functions. Fatty Acids, Omega-3 53-84 Polyunsaturated fatty acid percentage Sus scrofa 90-94 29452256-1 2018 Polyunsaturated fatty acids (PUFA"s) are majorly classified as omega-3 and omega-6 fatty acids. Fatty Acids, Omega-3 63-70 pumilio RNA binding family member 3 Homo sapiens 29-33 29096149-3 2018 Due to their potent anti-inflammatory effects, n-3 polyunsaturated fatty acids (n-3 PUFA) are a promising and safe dietary intervention in reducing breast cancer risk. Fatty Acids, Omega-3 47-78 pumilio RNA binding family member 3 Homo sapiens 84-88 29203442-9 2018 Results showed that n-3 PUFA enriched diet prevented the Abeta- induced depressive-like behaviors, as reveled by the reduction in the immobility time in the FST test. Fatty Acids, Omega-3 20-28 amyloid beta precursor protein Rattus norvegicus 57-62 29537934-2 2018 The n-3 Polyunsaturated Fatty acids prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance. Fatty Acids, Omega-3 4-35 insulin Homo sapiens 110-117 29331380-1 2018 The omega-3 fatty acid eicosapentaenoic acid (EPA) reduces oxidation of ApoB-containing particles in vitro and in patients with hypertriglyceridemia. Fatty Acids, Omega-3 4-22 apolipoprotein B Homo sapiens 72-76 29174352-1 2018 As one of the most important environmental factors, oxygen is particularly important for synthesis of n-3 polyunsaturated fatty acids (n-3 PUFA) in microalgae. Fatty Acids, Omega-3 102-133 pumilio RNA binding family member 3 Homo sapiens 139-143 29324650-0 2018 Update on the Impact of Omega 3 Fatty Acids on Inflammation, Insulin Resistance and Sarcopenia: A Review. Fatty Acids, Omega-3 24-43 insulin Homo sapiens 61-68 29324650-2 2018 Omega 3 fatty acids (FA) attenuate inflammation and age-associated muscle loss, prevent systemic insulin resistance and improve plasma lipids, potentially impacting on sarcopenia. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 97-104 29324650-3 2018 This paper aims to review recent randomized clinical studies assessing the effects a chronic omega 3 FA supplementation on inflammatory and metabolic profile during conditions characterized by sarcopenia (aging, insulin resistance, type 2 diabetes, chronic renal failure). Fatty Acids, Omega-3 93-103 insulin Homo sapiens 212-219 29258748-12 2018 The continued inflammation following omega3-PUFAs + timolol treatment suggests that downregulation of IL-18 and TNF-alpha may not be the only factors involved in omega3-PUFA-mediated neuroprotection in the retina. Fatty Acids, Omega-3 37-49 interleukin 18 Mus musculus 102-107 29573267-1 2018 The aim of this study was to determine the effect of n3 polyunsaturated fatty acids (PUFA) on canine adipose tissue secretion of adiponectin, interleukin-6 (IL6), and tumor necrosis factor-alpha (TNFalpha). Fatty Acids, Omega-3 53-83 adiponectin, C1Q and collagen domain containing Canis lupus familiaris 129-140 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Fatty Acids, Omega-3 25-40 interleukin 1 beta Rattus norvegicus 144-161 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Fatty Acids, Omega-3 25-40 interleukin 1 beta Rattus norvegicus 163-171 29352206-7 2018 Additionally, in complex formulations of OM-3 fatty acids, high levels of palmitic acid could reduce the in vivo effect on crystal-mediated IL-1beta elevation. Fatty Acids, Omega-3 41-57 interleukin 1 beta Rattus norvegicus 140-148 29537934-3 2018 Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptide-1 in tissue containing high levels of n-3 Polyunsaturated Fatty acids than lower level of n-3 Polyunsaturated Fatty acids. Fatty Acids, Omega-3 122-153 insulin Homo sapiens 0-7 30147809-0 2018 Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen? Fatty Acids, Omega-3 28-47 fibrinogen beta chain Homo sapiens 96-106 29537934-3 2018 Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptide-1 in tissue containing high levels of n-3 Polyunsaturated Fatty acids than lower level of n-3 Polyunsaturated Fatty acids. Fatty Acids, Omega-3 122-153 glucagon Homo sapiens 61-85 30147809-5 2018 Each 5.6 mug/m3 increase in PM2.5 concentration in the previous hour was associated with a 3.1% increase in fibrinogen (95% CI = 1.5%, 4.7%) in those subjects with LOWMED total omega-3 fatty acid levels, but only a 0.9% increase (95% CI = - 1.5%, 3.2%) in patients with HIGH total omega-3 fatty acid levels. Fatty Acids, Omega-3 177-195 fibrinogen beta chain Homo sapiens 108-118 30147809-5 2018 Each 5.6 mug/m3 increase in PM2.5 concentration in the previous hour was associated with a 3.1% increase in fibrinogen (95% CI = 1.5%, 4.7%) in those subjects with LOWMED total omega-3 fatty acid levels, but only a 0.9% increase (95% CI = - 1.5%, 3.2%) in patients with HIGH total omega-3 fatty acid levels. Fatty Acids, Omega-3 281-299 fibrinogen beta chain Homo sapiens 108-118 29537934-3 2018 Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptide-1 in tissue containing high levels of n-3 Polyunsaturated Fatty acids than lower level of n-3 Polyunsaturated Fatty acids. Fatty Acids, Omega-3 174-205 insulin Homo sapiens 0-7 30147809-8 2018 Thus, increased blood levels of fish-based omega-3 fatty acids attenuated increases in fibrinogen associated with short-term increases in ambient PM. Fatty Acids, Omega-3 43-62 fibrinogen beta chain Homo sapiens 87-97 29537934-3 2018 Insulin secretion is stimulated by glucose, amino acids, and glucagon- like peptide-1 in tissue containing high levels of n-3 Polyunsaturated Fatty acids than lower level of n-3 Polyunsaturated Fatty acids. Fatty Acids, Omega-3 174-205 glucagon Homo sapiens 61-85 29537934-4 2018 Also, n-3 Polyunsaturated Fatty acids led to decreased production of prostaglandin, which in turn contributed to the elevation of insulin secretion. Fatty Acids, Omega-3 6-37 insulin Homo sapiens 130-137 29537934-6 2018 Supplementation of n-3 Polyunsaturated Fatty acids for human subjects prevent beta cell destruction and insulin resistance. Fatty Acids, Omega-3 19-50 insulin Homo sapiens 104-111 29537934-8 2018 Therefore there should be a focus on the treatment mechanism of insulin related obesity and diabetes by n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 104-135 insulin Homo sapiens 64-71 29222889-9 2018 Meta-analysis also indicated that omega-3 fatty acids increased the level of CD4+ and CD4+/CD8+ ratio. Fatty Acids, Omega-3 34-53 CD4 molecule Homo sapiens 77-80 29222889-9 2018 Meta-analysis also indicated that omega-3 fatty acids increased the level of CD4+ and CD4+/CD8+ ratio. Fatty Acids, Omega-3 34-53 CD4 molecule Homo sapiens 86-89 29222889-9 2018 Meta-analysis also indicated that omega-3 fatty acids increased the level of CD4+ and CD4+/CD8+ ratio. Fatty Acids, Omega-3 34-53 CD8a molecule Homo sapiens 91-94 29321392-0 2018 [The role of brain n-3 fatty acids-GPR40/FFAR1 signaling in pain]. Fatty Acids, Omega-3 19-34 free fatty acid receptor 1 Homo sapiens 35-40 29044636-0 2018 An inverse association between serum resistin levels and n-3 polyunsaturated fatty acids intake was strongest in the SNP-420 G/G genotype in the Japanese cohort: The Toon Genome Study. Fatty Acids, Omega-3 57-88 resistin Homo sapiens 37-45 29044636-10 2018 Serum resistin was inversely associated with n-3 polyunsaturated fatty acids (PUFA) intake after adjustment for age, sex, BMI and energy intake (Q1 12.5, Q2 12.5, Q3 12.2, Q4 11.5 ng/mL; P for trend = .007). Fatty Acids, Omega-3 45-76 resistin Homo sapiens 6-14 28595549-4 2018 Although many drugs such as fibrates, statins and omega-3 fatty acids modestly decrease triglyceride levels (and apoC-III concentrations), there are many patients who still have severe hypertriglyceridemia and are at increased risk for pancreatitis and potentially for CVD. Fatty Acids, Omega-3 50-69 apolipoprotein C3 Homo sapiens 113-121 29105065-0 2018 Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets. Fatty Acids, Omega-3 161-179 fatty acid binding protein 5, epidermal Mus musculus 42-70 29938621-0 2018 A Novel Combination of omega-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study. Fatty Acids, Omega-3 23-42 interleukin 6 Homo sapiens 71-84 29938621-2 2018 Curcumin and omega-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. Fatty Acids, Omega-3 13-32 interleukin 6 Homo sapiens 89-93 29938621-2 2018 Curcumin and omega-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. Fatty Acids, Omega-3 13-32 C-reactive protein Homo sapiens 114-117 29938621-3 2018 The aim of present study is the evaluation of combined effects of omega-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and hs-CRP levels in migraine patients. Fatty Acids, Omega-3 66-85 interleukin 6 Homo sapiens 123-127 29938621-6 2018 RESULTS: The results showed that both of omega-3 and nano-curcumin down-regulated IL-6 mRAN and significantly decreased the serum concentration. Fatty Acids, Omega-3 41-48 interleukin 6 Homo sapiens 82-86 29321392-6 2018 Therefore, it is possible that the brain n-3 fatty acid-GPR40/FFAR1 signaling may play a key role in the modulation of the endogenous pain control system and emotional function. Fatty Acids, Omega-3 41-55 free fatty acid receptor 1 Homo sapiens 56-61 29321392-6 2018 Therefore, it is possible that the brain n-3 fatty acid-GPR40/FFAR1 signaling may play a key role in the modulation of the endogenous pain control system and emotional function. Fatty Acids, Omega-3 41-55 free fatty acid receptor 1 Homo sapiens 62-67 29321392-7 2018 Here, we discuss the role of brain n-3 fatty acids-GPR40/FFAR1 signaling in a pain, and we review the current status and future prospects of the brain GPR40/FFAR1. Fatty Acids, Omega-3 35-50 free fatty acid receptor 1 Homo sapiens 51-56 30175329-5 2018 RESULTS: By the end of the study period, the omega-3-treated group achieved a greater mean probing pocket depth reduction, a mean gain in clinical attachment level especially in deep periodontal pockets, as well as a greater increase in SOD activity (p < 0.01) compared to SRP alone. Fatty Acids, Omega-3 45-52 superoxide dismutase 1 Homo sapiens 237-240 28843519-1 2017 Fat-1 transgenic cattle have high levels of omega-3 fatty acids, which regulate several genes in fatty acid metabolism. Fatty Acids, Omega-3 44-63 FAT atypical cadherin 1 Bos taurus 0-5 28843519-9 2017 Together, these results suggest that miRNAs potentially play a role in expression of lipogenic and lipolytic genes as well as in synthesis of omega-3 fatty acids facilitated by fat-1. Fatty Acids, Omega-3 142-161 FAT atypical cadherin 1 Bos taurus 177-182 29412387-10 2017 Supplementation with n-3 PUFA modestly increases adiponectin levels, whereas conjugated linoleic acid supplementation appears to reduce concentrations when compared with unsaturated fatty acid supplementation used as an active placebo. Fatty Acids, Omega-3 21-29 adiponectin, C1Q and collagen domain containing Homo sapiens 49-60 28900676-5 2017 Because fat-1 Tg+ mice, in which n-6 is endogenously converted into n-3 FAs, contain high n-3 FA levels, they could be a good animal model for studying the effects of n-3 FAs in vivo. Fatty Acids, Omega-3 68-75 FAT atypical cadherin 1 Mus musculus 8-13 28847514-7 2017 Our findings identify that endogenous and exogenous n-3 PUFA enrichment ameliorated alcoholic liver injury by activation of GPR120 to suppress ethanol-stimulated adipose lipolysis, which provides the new insight to the hepatoprotective effect of n-3 PUFA against alcoholic liver disease. Fatty Acids, Omega-3 52-60 free fatty acid receptor 4 Mus musculus 124-130 28847514-7 2017 Our findings identify that endogenous and exogenous n-3 PUFA enrichment ameliorated alcoholic liver injury by activation of GPR120 to suppress ethanol-stimulated adipose lipolysis, which provides the new insight to the hepatoprotective effect of n-3 PUFA against alcoholic liver disease. Fatty Acids, Omega-3 246-254 free fatty acid receptor 4 Mus musculus 124-130 29034731-8 2017 CONCLUSION: Omega-3 fatty acids reduced postmenopausal women"s serum osteocalcin. Fatty Acids, Omega-3 12-31 bone gamma-carboxyglutamate protein Homo sapiens 69-80 28990050-0 2017 Dietary n-3 polyunsaturated fatty acids ameliorate Crohn"s disease in rats by modulating the expression of PPAR-gamma/NFAT. Fatty Acids, Omega-3 8-39 peroxisome proliferator-activated receptor gamma Rattus norvegicus 107-117 28756577-9 2017 In addition, there was an increase in GFAP-positive cells in the cerebral cortex of the HFD group, showing that omega-3 supplementation can be effective to decrease astrogliosis. Fatty Acids, Omega-3 112-119 glial fibrillary acidic protein Rattus norvegicus 38-42 28990050-0 2017 Dietary n-3 polyunsaturated fatty acids ameliorate Crohn"s disease in rats by modulating the expression of PPAR-gamma/NFAT. Fatty Acids, Omega-3 8-39 nuclear factor of activated T-cells 5 Rattus norvegicus 118-122 28990050-10 2017 In conclusion, the present study demonstrated that dietary n-3 PUFA may attenuate experimental CD induced by TNBS in rats by regulating the expression and activity of the PPAR-gamma/NFAT signaling pathway. Fatty Acids, Omega-3 59-67 peroxisome proliferator-activated receptor gamma Rattus norvegicus 171-181 28990050-10 2017 In conclusion, the present study demonstrated that dietary n-3 PUFA may attenuate experimental CD induced by TNBS in rats by regulating the expression and activity of the PPAR-gamma/NFAT signaling pathway. Fatty Acids, Omega-3 59-67 nuclear factor of activated T-cells 5 Rattus norvegicus 182-186 29096838-3 2017 However, until now only little is known about the effect of apheresis treatment on the levels of omega-6 and omega-3 polyunsaturated fatty acids (n-6 PUFA and n-3 PUFA) in patients. Fatty Acids, Omega-3 109-144 pumilio RNA binding family member 3 Homo sapiens 150-154 28972610-2 2017 This study aimed to investigate whether fat-1 transgenic mice with a higher tissue content of n-3 polyunsaturated fatty acids (PUFAs) could prevent HFS diet-induced NAFLD, compared with wild-type mice. Fatty Acids, Omega-3 94-125 FAT atypical cadherin 1 Mus musculus 40-45 28972610-10 2017 The endogenously synthesized n-3 PUFAs of the three fat-1 groups, which inhibit fatty acid synthesis and the TLR-4 signaling pathway, prevent HFS diet-induced NAFLD. Fatty Acids, Omega-3 29-38 FAT atypical cadherin 1 Mus musculus 52-57 28972610-10 2017 The endogenously synthesized n-3 PUFAs of the three fat-1 groups, which inhibit fatty acid synthesis and the TLR-4 signaling pathway, prevent HFS diet-induced NAFLD. Fatty Acids, Omega-3 29-38 toll-like receptor 4 Mus musculus 109-114 29137111-0 2017 Effect of Omega-3 Fatty Acid Supplementation on Plasma Fibroblast Growth Factor 23 Levels in Post-Myocardial Infarction Patients with Chronic Kidney Disease: The Alpha Omega Trial. Fatty Acids, Omega-3 10-28 fibroblast growth factor 23 Homo sapiens 55-82 29137111-3 2017 We examined the effect of marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and plant-derived alpha-linolenic acid (ALA) on plasma FGF23 levels in post-myocardial infarction patients with chronic kidney disease. Fatty Acids, Omega-3 33-48 fibroblast growth factor 23 Homo sapiens 163-168 29096837-4 2017 Although many drugs such as fibrates, statins and omega-3 fatty acids modestly decrease triglyceride levels (and apo-CIII concentrations), there are many patients who still have severe hypertriglyceridemia and are at risk for pancreatitis and potentially CVD. Fatty Acids, Omega-3 50-69 apolipoprotein C3 Homo sapiens 113-121 28881099-13 2017 Caspase-3 mRNA and protein expression were increased in aspartame treated cells, and these levels were reduced following omega-3 fatty acids treatment. Fatty Acids, Omega-3 121-140 caspase 3 Canis lupus familiaris 0-9 28666108-4 2017 The percentage of n-3 polyunsaturated fatty acid (n-3 PUFA) and the percentage of monounsaturated fatty acid in OEO muscle were higher and lower than those in RPD muscle, respectively. Fatty Acids, Omega-3 18-48 Polyunsaturated fatty acid percentage Sus scrofa 54-58 29031395-5 2017 After controlling for body mass index (BMI) and insulin, energy-adjusted dietary intake of SFA was positively and MUFA and n-3 fatty acids were negatively associated with subcutaneous and visceral adipose tissues leptin gene expression. Fatty Acids, Omega-3 123-138 leptin Homo sapiens 213-219 28984787-1 2017 OBJECTIVES: The aims of this study were to determine the effects of omega-3 fatty acids (omega-3FAs) on the Toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signaling pathway in the pancreas of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 68-87 toll-like receptor 4 Rattus norvegicus 108-128 28984787-1 2017 OBJECTIVES: The aims of this study were to determine the effects of omega-3 fatty acids (omega-3FAs) on the Toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signaling pathway in the pancreas of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 68-87 toll-like receptor 4 Rattus norvegicus 130-134 28984787-1 2017 OBJECTIVES: The aims of this study were to determine the effects of omega-3 fatty acids (omega-3FAs) on the Toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signaling pathway in the pancreas of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 89-99 toll-like receptor 4 Rattus norvegicus 108-128 28984787-1 2017 OBJECTIVES: The aims of this study were to determine the effects of omega-3 fatty acids (omega-3FAs) on the Toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signaling pathway in the pancreas of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 89-99 toll-like receptor 4 Rattus norvegicus 130-134 28583889-0 2017 A diet rich in omega-3 fatty acids enhances expression of soluble epoxide hydrolase in murine brain. Fatty Acids, Omega-3 15-34 epoxide hydrolase 2, cytoplasmic Mus musculus 58-83 29031395-10 2017 Habitual intake of SFA, MUFA, and n-3 fatty acids were associated with leptin gene expression in visceral and subcutaneous adipose tissues, suggesting an important role of quality and quantity of fatty acids intake in adipose tissue to regulate leptin expression. Fatty Acids, Omega-3 34-49 leptin Homo sapiens 71-77 29031395-10 2017 Habitual intake of SFA, MUFA, and n-3 fatty acids were associated with leptin gene expression in visceral and subcutaneous adipose tissues, suggesting an important role of quality and quantity of fatty acids intake in adipose tissue to regulate leptin expression. Fatty Acids, Omega-3 34-49 leptin Homo sapiens 245-251 29048366-0 2017 Lipase-Catalyzed Transesterification of Egg-Yolk Phophatidylcholine with Concentrate of n-3 Polyunsaturated Fatty Acids from Cod Liver Oil. Fatty Acids, Omega-3 88-119 PAN0_003d1715 Moesziomyces antarcticus 0-6 29064409-1 2017 Although there is accumulating evidence for a protective role of n-3 polyunsaturated fatty acids (n-3 PUFAs) on bone health, there are limited studies that examine the effect of altering dietary n-6:n-3 PUFA ratio with plant and marine sources of n-3 PUFA on bone health. Fatty Acids, Omega-3 65-96 pumilio RNA binding family member 3 Homo sapiens 102-106 29078847-0 2017 Involvement of Resveratrol and omega-3 Polyunsaturated Fatty Acids on Sirtuin 1 Gene Expression in THP1 Cells. Fatty Acids, Omega-3 31-66 sirtuin 1 Homo sapiens 70-79 29030414-1 2017 OBJECTIVES: Assess the association between marine omega-3 polyunsaturated fatty acid (n-3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. Fatty Acids, Omega-3 50-84 pumilio RNA binding family member 3 Homo sapiens 90-94 28978477-0 2017 Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling. Fatty Acids, Omega-3 0-19 transient receptor potential cation channel subfamily V member 4 Homo sapiens 29-34 28978477-3 2017 Here, we studied the contribution of omega-3 PUFAs to TRPV4 function by precisely manipulating the fatty acid content in Caenorhabditis elegans. Fatty Acids, Omega-3 37-50 transient receptor potential cation channel subfamily V member 4 Homo sapiens 54-59 28978477-4 2017 By genetically depriving the worms of PUFAs, we determined that the metabolism of omega-3 fatty acids is required for TRPV4 activity. Fatty Acids, Omega-3 82-101 transient receptor potential cation channel subfamily V member 4 Homo sapiens 118-123 28772063-0 2017 The omega-3 fatty acid alpha-linolenic acid extends Caenorhabditis elegans lifespan via NHR-49/PPARalpha and oxidation to oxylipins. Fatty Acids, Omega-3 4-22 NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49 Caenorhabditis elegans 88-94 28772063-2 2017 Additionally, long-lived Caenorhabditis elegans glp-1 germ line-less mutant animals show a number of changes in lipid metabolism including the increased production of the omega-3 fatty acid, alpha-linolenic acid (ALA). Fatty Acids, Omega-3 171-189 glp-1/Notch intracellular domain Caenorhabditis elegans 48-53 29078847-0 2017 Involvement of Resveratrol and omega-3 Polyunsaturated Fatty Acids on Sirtuin 1 Gene Expression in THP1 Cells. Fatty Acids, Omega-3 31-66 GLI family zinc finger 2 Homo sapiens 99-103 29078847-4 2017 Resveratol, eicosapentaenoic acid (EPA) and docosahexaeanoic acid (DHA) as n-3 polyunsaturated fatty acid were added on THP1 cells. Fatty Acids, Omega-3 75-105 GLI family zinc finger 2 Homo sapiens 120-124 28835582-4 2017 The serum levels of n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid and docosahexaenoic acid, are reportedly associated with an increased incidence of cardiovascular events and mortality, whereas the addition of n-3 PUFA treatment to the statin treatment decreases cardiovascular events. Fatty Acids, Omega-3 20-51 pumilio RNA binding family member 3 Homo sapiens 53-57 28529072-7 2017 Our results show common effects of monoaminergic antidepressants and omega-3 fatty acids on the reduction of neurogenesis caused by IL-1beta, but acting through both common and different kynurenine pathway-related mechanisms. Fatty Acids, Omega-3 69-88 interleukin 1 beta Homo sapiens 132-140 28529072-0 2017 Rescue of IL-1beta-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants. Fatty Acids, Omega-3 62-81 interleukin 1 beta Homo sapiens 10-18 28634213-0 2017 Omega-3 fatty acids increase the unfolded protein response and improve amyloid-beta phagocytosis by macrophages of patients with mild cognitive impairment. Fatty Acids, Omega-3 0-19 amyloid beta precursor protein Homo sapiens 71-83 28634213-2 2017 Omega-3 fatty acids (omega-3s) in vitro and in vivo and the omega-3 mediator, resolvin D1, in vitro increase Abeta phagocytosis by Mphis of patients with MCI. Fatty Acids, Omega-3 0-19 amyloid beta precursor protein Homo sapiens 109-114 28634213-2 2017 Omega-3 fatty acids (omega-3s) in vitro and in vivo and the omega-3 mediator, resolvin D1, in vitro increase Abeta phagocytosis by Mphis of patients with MCI. Fatty Acids, Omega-3 21-29 amyloid beta precursor protein Homo sapiens 109-114 28767202-8 2017 A weak negative correlation occurred between post-OVH CRP and postinfusion total long-chain omega-3 FA concentrations (r2 = 0.21, P = 0.014). Fatty Acids, Omega-3 92-102 C-reactive protein Canis lupus familiaris 54-57 27132650-0 2017 Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids. Fatty Acids, Omega-3 119-138 brain-derived neurotrophic factor Rattus norvegicus 17-50 27132650-0 2017 Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids. Fatty Acids, Omega-3 119-138 brain-derived neurotrophic factor Rattus norvegicus 52-56 27132650-1 2017 PURPOSE: The aim of this study was investigating the effect of omega-3 fatty acids (omega-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. Fatty Acids, Omega-3 63-82 brain-derived neurotrophic factor Rattus norvegicus 100-133 27132650-1 2017 PURPOSE: The aim of this study was investigating the effect of omega-3 fatty acids (omega-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. Fatty Acids, Omega-3 63-82 brain-derived neurotrophic factor Rattus norvegicus 135-139 27132650-1 2017 PURPOSE: The aim of this study was investigating the effect of omega-3 fatty acids (omega-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. Fatty Acids, Omega-3 84-95 brain-derived neurotrophic factor Rattus norvegicus 100-133 27132650-1 2017 PURPOSE: The aim of this study was investigating the effect of omega-3 fatty acids (omega-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. Fatty Acids, Omega-3 84-95 brain-derived neurotrophic factor Rattus norvegicus 135-139 27132650-3 2017 For the in vitro experiment, hypothalamic cells from six obese rats were cultured in the presence of different concentrations of omega-3 FAs to determine its direct effect on BDNF expression. Fatty Acids, Omega-3 129-140 brain-derived neurotrophic factor Rattus norvegicus 175-179 27132650-4 2017 RESULTS: In vivo results showed that obesity has negative effect on BDNF gene expression in rat hypothalamus that was reversed by administration of omega-3 FAs. Fatty Acids, Omega-3 148-159 brain-derived neurotrophic factor Rattus norvegicus 68-72 27132650-9 2017 CONCLUSIONS: Obesity causes down-regulation of BDNF gene expression that can be reversed by omega-3 FAs treatment, making them an interesting treatment approach for obesity and metabolic disease. Fatty Acids, Omega-3 92-103 brain-derived neurotrophic factor Rattus norvegicus 47-51 28912452-0 2017 Endogenous omega-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis. Fatty Acids, Omega-3 11-29 FAT atypical cadherin 1 Mus musculus 44-49 28932392-0 2017 Galectin-3, a marker of cardiac remodeling, is inversely related to serum levels of marine omega-3 fatty acids. Fatty Acids, Omega-3 91-110 galectin 3 Homo sapiens 0-10 28886129-1 2017 Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associated with omega-3 polyunsaturated fatty acids (n3-PUFA). Fatty Acids, Omega-3 108-143 FAT atypical cadherin 1 Mus musculus 33-38 28886129-1 2017 Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associated with omega-3 polyunsaturated fatty acids (n3-PUFA). Fatty Acids, Omega-3 145-152 FAT atypical cadherin 1 Mus musculus 33-38 28886129-7 2017 In plasma of n3-PUFA fed animals, EPA and DHA metabolites from the lipoxygenase and cytochrome P450 pathways dominated over ARA derived counterparts.Fat-1 mice show n3-PUFA level which can be reached by dietary interventions, supporting the applicability of this model in n3-PUFA research. Fatty Acids, Omega-3 13-20 FAT atypical cadherin 1 Mus musculus 149-154 28771600-12 2017 GPR120, a receptor of n-3 fatty acids, gene knockdown by siRNA canceled effects of EPA on NOX4 gene expression and NOX activity in arterial SMCs of klotho mice. Fatty Acids, Omega-3 22-37 free fatty acid receptor 4 Mus musculus 0-6 28337705-9 2017 It is concluded that treatment with omega-3 fatty acids and antioxidant vitamins reduces oxidative and nitrosative stress and prevents Cx40/Cx43 lateralization in atrial tissue likely contributing to POAF prevention. Fatty Acids, Omega-3 36-55 gap junction protein alpha 5 Homo sapiens 135-139 28337705-9 2017 It is concluded that treatment with omega-3 fatty acids and antioxidant vitamins reduces oxidative and nitrosative stress and prevents Cx40/Cx43 lateralization in atrial tissue likely contributing to POAF prevention. Fatty Acids, Omega-3 36-55 gap junction protein alpha 1 Homo sapiens 140-144 28606477-0 2017 N-3 polyunsaturated fatty acid-enriched lipid emulsion improves Paneth cell function via the IL-22/Stat3 pathway in a mouse model of total parenteral nutrition. Fatty Acids, Omega-3 0-30 interleukin 22 Mus musculus 93-98 28606477-0 2017 N-3 polyunsaturated fatty acid-enriched lipid emulsion improves Paneth cell function via the IL-22/Stat3 pathway in a mouse model of total parenteral nutrition. Fatty Acids, Omega-3 0-30 signal transducer and activator of transcription 3 Mus musculus 99-104 28854755-2 2017 Providing long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) during gestation and early life has been shown to improve the brain development and function of human and rodent offspring. Fatty Acids, Omega-3 21-52 pumilio RNA binding family member 3 Homo sapiens 61-65 28891094-9 2017 In this review, we highlight natural compounds, such as curcumin, indol-3 carbinol, and omega-3 fatty acids, that have the potential to restore or potentiate PTEN expression/activity, thereby suppressing cancer cell proliferation, survival, and resistance to chemotherapeutic agents. Fatty Acids, Omega-3 88-107 phosphatase and tensin homolog Homo sapiens 158-162 27271094-9 2017 RESULTS: Higher than median intake of omega-6 polyunsaturated fatty acids (n-6 PUFA) was associated with increased serum level of 8-isoprostane F2alpha in subjects with TT/TC genotype (p = 0.004), and higher than median intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) was associated with increased serum SOD activity in CC genotype (p < 0.001). Fatty Acids, Omega-3 230-265 pumilio RNA binding family member 3 Homo sapiens 79-83 28810616-9 2017 It was concluded that Omega-3 fatty acids improved T helper/inducer and CD4/CD8 ratios, and may have reduced mortality, among septic patients with intestinal dysfunction. Fatty Acids, Omega-3 22-41 CD4 molecule Homo sapiens 72-75 28655519-0 2017 Omega-3 polyunsaturated fatty acids ameliorates testicular ischemia-reperfusion injury through the induction of Nrf2 and inhibition of NF-kappaB in rats. Fatty Acids, Omega-3 0-35 NFE2 like bZIP transcription factor 2 Rattus norvegicus 112-116 28420693-5 2017 Recent studies of fish-derived omega-3 supplementation in patients with MCI have shown polarization of Apoepsilon3/epsilon3 patients" macrophages to an intermediate M1-M2 phenotype that is optimal for Abeta phagocytosis and the stabilization of cognitive decline. Fatty Acids, Omega-3 31-38 amyloid beta precursor protein Homo sapiens 201-206 28810616-9 2017 It was concluded that Omega-3 fatty acids improved T helper/inducer and CD4/CD8 ratios, and may have reduced mortality, among septic patients with intestinal dysfunction. Fatty Acids, Omega-3 22-41 CD8a molecule Homo sapiens 76-79 28831714-0 2017 Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study. Fatty Acids, Omega-3 0-18 microtubule associated protein tau Homo sapiens 116-120 28280951-0 2017 Effects of dietary n-3 fatty acids on Toll-like receptor activation in primary leucocytes from Atlantic salmon (Salmo salar). Fatty Acids, Omega-3 19-34 toll-like receptor 12 Salmo salar 38-56 28400162-8 2017 Most mammalian ALOX15 orthologs exhibit dual positional specificity with highly unsaturated n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 92-123 arachidonate 15-lipoxygenase Homo sapiens 15-21 28391389-2 2017 The aim of this study is to analyze whether combination therapy with omega-3 fatty acids, which have anti-inflammatory and COX-2 inhibitory effects, and tamsulocin plus finasteride offers an advantage compared to tamsulocin plus finasteride therapy in patients with BPH. Fatty Acids, Omega-3 69-88 prostaglandin-endoperoxide synthase 2 Homo sapiens 123-128 28177133-0 2017 Dietary supplementation with low-dose omega-3 fatty acids reduces salivary tumor necrosis factor-alpha levels in patients with chronic periodontitis: a randomized controlled clinical study. Fatty Acids, Omega-3 38-57 tumor necrosis factor Homo sapiens 75-102 28177133-10 2017 CONCLUSION: The results demonstrated that dietary supplementation with low-dose omega-3 PUFAs improves salivary TNF-alpha without any significant impact on clinical parameters in patients with chronic periodontitis, suggesting that the systemic benefits of dietary omega-3 PUFAs may not be translated to periodontal health. Fatty Acids, Omega-3 80-87 tumor necrosis factor Homo sapiens 112-121 28763008-0 2017 Omega-3 Fatty Acids Supplementation Differentially Modulates the SDF-1/CXCR-4 Cell Homing Axis in Hypertensive and Normotensive Rats. Fatty Acids, Omega-3 0-19 C-X-C motif chemokine ligand 12 Rattus norvegicus 65-70 28763008-0 2017 Omega-3 Fatty Acids Supplementation Differentially Modulates the SDF-1/CXCR-4 Cell Homing Axis in Hypertensive and Normotensive Rats. Fatty Acids, Omega-3 0-19 C-X-C motif chemokine receptor 4 Rattus norvegicus 71-77 28763008-1 2017 BACKGROUND: We assessed the effect of acute and chronic dietary supplementation of omega-3 on lipid metabolism and cardiac regeneration, through its influence on the Stromal Derived Factor-1 (SDF-1) and its receptor (CXCR4) axis in normotensive and hypertensive rats. Fatty Acids, Omega-3 83-90 C-X-C motif chemokine ligand 12 Rattus norvegicus 166-190 28763008-1 2017 BACKGROUND: We assessed the effect of acute and chronic dietary supplementation of omega-3 on lipid metabolism and cardiac regeneration, through its influence on the Stromal Derived Factor-1 (SDF-1) and its receptor (CXCR4) axis in normotensive and hypertensive rats. Fatty Acids, Omega-3 83-90 C-X-C motif chemokine ligand 12 Rattus norvegicus 192-197 28763008-1 2017 BACKGROUND: We assessed the effect of acute and chronic dietary supplementation of omega-3 on lipid metabolism and cardiac regeneration, through its influence on the Stromal Derived Factor-1 (SDF-1) and its receptor (CXCR4) axis in normotensive and hypertensive rats. Fatty Acids, Omega-3 83-90 C-X-C motif chemokine receptor 4 Rattus norvegicus 217-222 28763008-5 2017 RESULTS: The use of omega-3 caused a reduction in total cholesterol levels (p = 0.044), and acutely activated the SDF-1/CXCR4 axis in normotensive animals (p = 0.037). Fatty Acids, Omega-3 20-27 C-X-C motif chemokine ligand 12 Rattus norvegicus 114-119 28763008-5 2017 RESULTS: The use of omega-3 caused a reduction in total cholesterol levels (p = 0.044), and acutely activated the SDF-1/CXCR4 axis in normotensive animals (p = 0.037). Fatty Acids, Omega-3 20-27 C-X-C motif chemokine receptor 4 Rattus norvegicus 120-125 28763008-6 2017 In the presence of the omega-3, after 72 h, SDF-1 levels decreased in WKY and increased in SHR (p = 0.017), and tissue expression of the receptor CXCR4 was higher in WKY than in SHR (p = 0.001). Fatty Acids, Omega-3 23-30 C-X-C motif chemokine ligand 12 Rattus norvegicus 44-49 28763008-6 2017 In the presence of the omega-3, after 72 h, SDF-1 levels decreased in WKY and increased in SHR (p = 0.017), and tissue expression of the receptor CXCR4 was higher in WKY than in SHR (p = 0.001). Fatty Acids, Omega-3 23-30 C-X-C motif chemokine receptor 4 Rattus norvegicus 146-151 28763008-8 2017 While WKY rats respond acutely to omega-3 supplementation, showing increased release of SDF-1 and CXCR4, SHR exhibit a weaker, delayed response. Fatty Acids, Omega-3 34-41 C-X-C motif chemokine ligand 12 Rattus norvegicus 88-93 28763008-8 2017 While WKY rats respond acutely to omega-3 supplementation, showing increased release of SDF-1 and CXCR4, SHR exhibit a weaker, delayed response. Fatty Acids, Omega-3 34-41 C-X-C motif chemokine receptor 4 Rattus norvegicus 98-103 29133192-8 2017 The combined supplementation of folic acid, vitamin B12 and omega-3 fatty acids improved placental IL-10 levels and decreased TNF-alpha levels in offspring livers. Fatty Acids, Omega-3 60-79 interleukin 10 Rattus norvegicus 99-104 29133192-8 2017 The combined supplementation of folic acid, vitamin B12 and omega-3 fatty acids improved placental IL-10 levels and decreased TNF-alpha levels in offspring livers. Fatty Acids, Omega-3 60-79 tumor necrosis factor Rattus norvegicus 126-135 27167127-5 2017 Fat-1 mice with high endogenous omega-3 PUFAs significantly inhibited ROS expression and attenuated parenchymal cell death after compression injury during the early injury phase. Fatty Acids, Omega-3 32-45 FAT atypical cadherin 1 Mus musculus 0-5 26223942-8 2017 Levels of stem cell factor (SCF) and fibroblast growth factor 1 (FGF-1) were significantly higher in bone marrow supernatants from mice that consumed the omega-3-rich diet. Fatty Acids, Omega-3 154-161 kit ligand Mus musculus 10-26 26223942-8 2017 Levels of stem cell factor (SCF) and fibroblast growth factor 1 (FGF-1) were significantly higher in bone marrow supernatants from mice that consumed the omega-3-rich diet. Fatty Acids, Omega-3 154-161 kit ligand Mus musculus 28-31 26223942-8 2017 Levels of stem cell factor (SCF) and fibroblast growth factor 1 (FGF-1) were significantly higher in bone marrow supernatants from mice that consumed the omega-3-rich diet. Fatty Acids, Omega-3 154-161 fibroblast growth factor 1 Mus musculus 37-63 26223942-8 2017 Levels of stem cell factor (SCF) and fibroblast growth factor 1 (FGF-1) were significantly higher in bone marrow supernatants from mice that consumed the omega-3-rich diet. Fatty Acids, Omega-3 154-161 fibroblast growth factor 1 Mus musculus 65-70 28721137-0 2017 Beneficial effects of n-3 polyunsaturated fatty acids on adiponectin levels and AdipoR gene expression in patients with type 2 diabetes mellitus: a randomized, placebo-controlled, double-blind clinical trial. Fatty Acids, Omega-3 22-53 adiponectin, C1Q and collagen domain containing Homo sapiens 57-68 28672788-0 2017 N-3 Polyunsaturated Fatty Acids Decrease the Protein Expression of Soluble Epoxide Hydrolase via Oxidative Stress-Induced P38 Kinase in Rat Endothelial Cells. Fatty Acids, Omega-3 0-31 epoxide hydrolase 2 Rattus norvegicus 67-92 29354704-3 2017 Methods: Nine-month-old animals were allocated to different groups: (A) C57BL/6 untreated , (B) CCL2-/- untreated, (C) CCL2-/- treated with omega-3+omega-6, and (D) CCL2-/- treated with omega-3. Fatty Acids, Omega-3 140-147 chemokine (C-C motif) ligand 2 Mus musculus 119-123 29354704-3 2017 Methods: Nine-month-old animals were allocated to different groups: (A) C57BL/6 untreated , (B) CCL2-/- untreated, (C) CCL2-/- treated with omega-3+omega-6, and (D) CCL2-/- treated with omega-3. Fatty Acids, Omega-3 140-147 chemokine (C-C motif) ligand 2 Mus musculus 119-123 29354704-12 2017 Conclusion: Supplementation with omega-3+omega-6 or omega-3 alone (AA/EPA=1-1.5) suggests a protective mechanism in the CCL2-/- animal model of dry AMD, with a more beneficial effect when omega-3 are used alone. Fatty Acids, Omega-3 33-40 chemokine (C-C motif) ligand 2 Mus musculus 120-124 29354704-12 2017 Conclusion: Supplementation with omega-3+omega-6 or omega-3 alone (AA/EPA=1-1.5) suggests a protective mechanism in the CCL2-/- animal model of dry AMD, with a more beneficial effect when omega-3 are used alone. Fatty Acids, Omega-3 52-59 chemokine (C-C motif) ligand 2 Mus musculus 120-124 29354704-12 2017 Conclusion: Supplementation with omega-3+omega-6 or omega-3 alone (AA/EPA=1-1.5) suggests a protective mechanism in the CCL2-/- animal model of dry AMD, with a more beneficial effect when omega-3 are used alone. Fatty Acids, Omega-3 52-59 chemokine (C-C motif) ligand 2 Mus musculus 120-124 28599665-11 2017 CONCLUSION: Omega-3 PUFAs supplementation may favorably affect lipid and inflammatory profile in chronic Chagas cardiomyopathy patients, demonstrated by a decrease in triglycerides and improvements on IL-10 concentration. Fatty Acids, Omega-3 12-25 interleukin 10 Homo sapiens 201-206 28314803-1 2017 A G protein-coupled receptor (GPCR) named free fatty acid receptor 4 (FFA4, also known as GPR120) was found to act as a GPCR for omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 129-164 free fatty acid receptor 4 Mus musculus 90-96 28456627-0 2017 Constitutive omega-3 fatty acid production in fat-1 transgenic mice and docosahexaenoic acid administration to wild type mice protect against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Fatty Acids, Omega-3 13-31 FAT atypical cadherin 1 Mus musculus 46-51 28456627-3 2017 Intrarectal administration of 2.5% 2,4,6-trinitrobenzene sulfonic acid (TNBS) caused inflammation in the colon of wild type mice, but this was less severe in fat-1 transgenic mice that constitutively produce omega-3 PUFAs from omega-6 PUFAs. Fatty Acids, Omega-3 208-221 FAT atypical cadherin 1 Mus musculus 158-163 28721137-10 2017 The serum level of adiponectin significantly (p = 0.035) increased in n-3 PUFAs (5.09 to 5.58 mug/ml) but remained unchanged in the placebo group. Fatty Acids, Omega-3 70-79 adiponectin, C1Q and collagen domain containing Homo sapiens 19-30 28721137-11 2017 CONCLUSIONS: Daily supplementation with n-3 PUFAs (2.7 g) was effective to significantly improve gene expression of AdipoR1 and AdipoR2 and the serum level of adiponectin in T2DM patients. Fatty Acids, Omega-3 40-49 adiponectin receptor 1 Homo sapiens 116-123 28721137-11 2017 CONCLUSIONS: Daily supplementation with n-3 PUFAs (2.7 g) was effective to significantly improve gene expression of AdipoR1 and AdipoR2 and the serum level of adiponectin in T2DM patients. Fatty Acids, Omega-3 40-49 adiponectin receptor 2 Homo sapiens 128-135 28721137-11 2017 CONCLUSIONS: Daily supplementation with n-3 PUFAs (2.7 g) was effective to significantly improve gene expression of AdipoR1 and AdipoR2 and the serum level of adiponectin in T2DM patients. Fatty Acids, Omega-3 40-49 adiponectin, C1Q and collagen domain containing Homo sapiens 159-170 27406859-6 2017 In separate post-hoc analyses, we observed that median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium and C20:5 n-3 fatty acid (p = 0.003). Fatty Acids, Omega-3 160-174 kallikrein related peptidase 3 Homo sapiens 55-58 27406859-6 2017 In separate post-hoc analyses, we observed that median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium and C20:5 n-3 fatty acid (p = 0.003). Fatty Acids, Omega-3 278-292 kallikrein related peptidase 3 Homo sapiens 55-58 28611031-3 2017 METHODS AND RESULTS: Using array-based and targeted genotyping, we found that rs80356779, a p.Pro479Leu variant in CPT1A, was strongly associated with markers of n-3 fatty acid metabolism, including degree of unsaturation (P=1.16x10-34), levels of polyunsaturated fatty acids, n-3 fatty acids, and docosahexaoenic acid relative to total fatty acid levels (P=2.35x10-15, P=4.02x10-19, and P=7.92x10-27). Fatty Acids, Omega-3 162-176 carnitine palmitoyltransferase 1A Homo sapiens 115-120 27406859-8 2017 CONCLUSIONS: Three week nutritional interventions with tomato-products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer. Fatty Acids, Omega-3 113-128 kallikrein related peptidase 3 Homo sapiens 135-138 28611031-3 2017 METHODS AND RESULTS: Using array-based and targeted genotyping, we found that rs80356779, a p.Pro479Leu variant in CPT1A, was strongly associated with markers of n-3 fatty acid metabolism, including degree of unsaturation (P=1.16x10-34), levels of polyunsaturated fatty acids, n-3 fatty acids, and docosahexaoenic acid relative to total fatty acid levels (P=2.35x10-15, P=4.02x10-19, and P=7.92x10-27). Fatty Acids, Omega-3 277-292 carnitine palmitoyltransferase 1A Homo sapiens 115-120 28145413-2 2017 The aim of our study was to explore the regulation of SCD-1 by Raloxifene and omega-3 fatty acids in women at increased risk of breast cancer based on high breast density. Fatty Acids, Omega-3 78-97 stearoyl-CoA desaturase Homo sapiens 54-59 28235206-0 2017 The Effects of Omega-3 Fatty Acids Supplementation on Gene Expression Involved in the Insulin and Lipid Signaling Pathway in Patients with Polycystic Ovary Syndrome. Fatty Acids, Omega-3 15-34 insulin Homo sapiens 86-93 28407657-1 2017 This study was conducted to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in women with polycystic ovary syndrome (PCOS). Fatty Acids, Omega-3 53-72 insulin Homo sapiens 120-127 28407657-8 2017 Omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PCOS women significantly improved indices of insulin resistance, total and free testosterone. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 114-121 28235206-1 2017 Limited data are available evaluating the effects of omega-3 fatty acids supplementation on gene expression involved in the insulin and lipid-signaling pathway in women with polycystic ovary syndrome (PCOS). Fatty Acids, Omega-3 53-72 insulin Homo sapiens 124-131 28235206-2 2017 This study was conducted to evaluate the effects of omega-3 fatty acids supplementation on gene expression involved in the insulin and lipid signaling pathway in women with PCOS. Fatty Acids, Omega-3 52-71 insulin Homo sapiens 123-130 28235206-6 2017 Quantitative results of RT-PCR demonstrated that compared with the placebo, omega-3 fatty acids supplementation upregulated peroxisome proliferator-activated receptor gamma (PPAR-gamma) mRNA (p=0.005) in peripheral blood mononuclear cells of women with PCOS. Fatty Acids, Omega-3 76-95 peroxisome proliferator activated receptor gamma Homo sapiens 124-172 28235206-6 2017 Quantitative results of RT-PCR demonstrated that compared with the placebo, omega-3 fatty acids supplementation upregulated peroxisome proliferator-activated receptor gamma (PPAR-gamma) mRNA (p=0.005) in peripheral blood mononuclear cells of women with PCOS. Fatty Acids, Omega-3 76-95 peroxisome proliferator activated receptor gamma Homo sapiens 174-184 28235206-7 2017 In addition, compared to the placebo, omega-3 fatty acids supplementation downregulated expressed levels of oxidized low-density lipoprotein receptor (LDLR) mRNA (p=0.002) in peripheral blood mononuclear cells of women with PCOS. Fatty Acids, Omega-3 38-57 low density lipoprotein receptor Homo sapiens 117-149 28235206-7 2017 In addition, compared to the placebo, omega-3 fatty acids supplementation downregulated expressed levels of oxidized low-density lipoprotein receptor (LDLR) mRNA (p=0.002) in peripheral blood mononuclear cells of women with PCOS. Fatty Acids, Omega-3 38-57 low density lipoprotein receptor Homo sapiens 151-155 28235206-9 2017 Overall, omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-gamma and LDLR. Fatty Acids, Omega-3 9-28 peroxisome proliferator activated receptor gamma Homo sapiens 114-124 28235206-9 2017 Overall, omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-gamma and LDLR. Fatty Acids, Omega-3 9-28 low density lipoprotein receptor Homo sapiens 129-133 27838193-0 2017 Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients. Fatty Acids, Omega-3 24-39 interleukin 6 Homo sapiens 105-109 28478481-4 2017 omega-3 fatty acids and curcumin exert neuroprotective and anti-inflammatory effects via several mechanisms including suppression of TNF-alpha gene expression and its serum levels. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 133-142 28478481-5 2017 The aim of this study is an evaluation of synergistic effects of omega-3 fatty acids and nano-curcumin on TNF-alpha gene expression and serum levels in migraine patients. Fatty Acids, Omega-3 65-84 tumor necrosis factor Homo sapiens 106-115 28478481-8 2017 Our results showed that the combination of omega-3 fatty acids and nano-curcumin downregulated TNF-alpha messenger RNA (mRNA) significantly in a synergistic manner (P < 0.05). Fatty Acids, Omega-3 43-62 tumor necrosis factor Homo sapiens 95-104 28202745-1 2017 OBJECTIVE: To determine whether levels of plasma n-3 polyunsaturated fatty acids are associated with response to antitumor necrosis factor (anti-TNF) agents in rheumatoid arthritis (RA), and whether this putative effect may have its basis in altering anti-TNF-driven Th17 cell differentiation. Fatty Acids, Omega-3 49-80 tumor necrosis factor Homo sapiens 145-148 28259037-11 2017 We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s. Fatty Acids, Omega-3 157-175 epoxide hydrolase 2 Homo sapiens 199-202 28524103-8 2017 Future targeted lipidomics-based studies will help discover whether n-3-polyunsaturated fatty acid (n-3-PUFA) supplementation enhances inflammation resolution in athletes post-exercise. Fatty Acids, Omega-3 68-98 pumilio RNA binding family member 3 Homo sapiens 104-108 28478481-0 2017 The synergistic effects of omega-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-alpha gene expression and serum level in migraine patients. Fatty Acids, Omega-3 27-46 tumor necrosis factor Homo sapiens 84-117 28213052-8 2017 Finally, better cognitive performance was observed in men compared to women and mixed results were also found for the influence of APOE4 genotype on the association between n-3 fatty acids or MedDiet and cognition. Fatty Acids, Omega-3 173-188 apolipoprotein E Homo sapiens 131-136 28379169-1 2017 The effect of marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFA) on long-term outcome in renal transplant recipients (RTR) remains unclear. Fatty Acids, Omega-3 29-64 pumilio RNA binding family member 3 Homo sapiens 70-74 28393852-0 2017 Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression. Fatty Acids, Omega-3 0-35 CREB regulated transcription coactivator 2 Mus musculus 98-104 28393852-3 2017 A Caenorhabditis elegans fat-1 transgenic mouse model in which n-3 PUFAs are endogenously produced from n-6 PUFAs owing to the expression of n-3 fatty acid desaturase were deployed. Fatty Acids, Omega-3 63-72 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 25-30 28104476-9 2017 Meanwhile, pretreatment with vit E or Omega-3 FA induced a significantly alleviation of the inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and the elevation of the anti-oxidative activity especially in the rats pretreated with combined vit E and Omega-3 FA. Fatty Acids, Omega-3 38-48 tumor necrosis factor Rattus norvegicus 116-125 28379838-1 2017 Omega-3 polyunsaturated fatty acids (n3-PUFA) are recognized for their anti-inflammatory effects and may be beneficial in the context of sarcopenia. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 40-44 29165130-1 2017 BACKGROUND: N-3 polyunsaturated fatty acids (n-3 PUFA) may have multiple beneficial effects on the outcome of pregnancy, maternal health and child development. Fatty Acids, Omega-3 12-43 pumilio RNA binding family member 3 Homo sapiens 49-53 28104476-9 2017 Meanwhile, pretreatment with vit E or Omega-3 FA induced a significantly alleviation of the inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and the elevation of the anti-oxidative activity especially in the rats pretreated with combined vit E and Omega-3 FA. Fatty Acids, Omega-3 38-48 interleukin 1 beta Rattus norvegicus 127-135 28104476-9 2017 Meanwhile, pretreatment with vit E or Omega-3 FA induced a significantly alleviation of the inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and the elevation of the anti-oxidative activity especially in the rats pretreated with combined vit E and Omega-3 FA. Fatty Acids, Omega-3 38-48 interleukin 6 Rattus norvegicus 137-141 26830417-0 2017 Down-regulation of NF-kappaB expression by n-3 fatty acid-rich linseed oil is modulated by PPARgamma activation, eicosanoid cascade and secretion of cytokines by macrophages in rats fed partially hydrogenated vegetable fat. Fatty Acids, Omega-3 43-57 peroxisome proliferator-activated receptor gamma Rattus norvegicus 91-100 27987060-5 2017 Moreover, superoxide dismutase (SOD) activity was decreased in the striatum (54%) in the prevention treatment, and the administration of omega3 fatty acids alone or in combination with Li and VPA partially prevented this inhibition. Fatty Acids, Omega-3 137-155 superoxide dismutase 1 Homo sapiens 10-30 28077335-0 2017 Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury. Fatty Acids, Omega-3 0-19 NLR family pyrin domain containing 3 Homo sapiens 29-34 28077335-3 2017 Rats treated with omega-3 FAs had significantly less TBI-induced caspase-1 cleavage and IL-1beta secretion than those with vehicle. Fatty Acids, Omega-3 18-29 caspase 1 Rattus norvegicus 65-74 28077335-3 2017 Rats treated with omega-3 FAs had significantly less TBI-induced caspase-1 cleavage and IL-1beta secretion than those with vehicle. Fatty Acids, Omega-3 18-29 interleukin 1 beta Rattus norvegicus 88-96 28077335-5 2017 GW1100, a GPR40 inhibitor, eliminated the anti-inflammatory effect of omega-3 FAs after TBI. Fatty Acids, Omega-3 70-81 free fatty acid receptor 1 Homo sapiens 10-15 28077335-9 2017 Collectively, these data indicate that the GPR40-mediated pathway is involved in the inhibitory effects of omega-3 FAs on TBI-induced inflammation and ARRB2 is activated to interact with NLRP3. Fatty Acids, Omega-3 107-118 free fatty acid receptor 1 Homo sapiens 43-48 28069365-1 2017 A body of evidence has implicated dietary deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of recurrent mood disorders including major depressive disorder (MDD) and bipolar disorder. Fatty Acids, Omega-3 56-91 pumilio RNA binding family member 3 Homo sapiens 97-101 28356106-10 2017 These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent. Fatty Acids, Omega-3 17-48 fos-like antigen 1 Mus musculus 113-117 28179493-10 2017 Dietary n-3 polyunsaturated fatty acids have been shown to reduce plasma PCSK9 concentration and hepatic PCSK9 mRNA expression, consistent with their lipid-lowering effects, whereas dietary fructose appears to upregulate PCSK9 mRNA expression and plasma PCSK9 concentrations. Fatty Acids, Omega-3 8-39 proprotein convertase subtilisin/kexin type 9 Homo sapiens 73-78 28179493-10 2017 Dietary n-3 polyunsaturated fatty acids have been shown to reduce plasma PCSK9 concentration and hepatic PCSK9 mRNA expression, consistent with their lipid-lowering effects, whereas dietary fructose appears to upregulate PCSK9 mRNA expression and plasma PCSK9 concentrations. Fatty Acids, Omega-3 8-39 proprotein convertase subtilisin/kexin type 9 Homo sapiens 105-110 28179493-10 2017 Dietary n-3 polyunsaturated fatty acids have been shown to reduce plasma PCSK9 concentration and hepatic PCSK9 mRNA expression, consistent with their lipid-lowering effects, whereas dietary fructose appears to upregulate PCSK9 mRNA expression and plasma PCSK9 concentrations. Fatty Acids, Omega-3 8-39 proprotein convertase subtilisin/kexin type 9 Homo sapiens 105-110 28179493-10 2017 Dietary n-3 polyunsaturated fatty acids have been shown to reduce plasma PCSK9 concentration and hepatic PCSK9 mRNA expression, consistent with their lipid-lowering effects, whereas dietary fructose appears to upregulate PCSK9 mRNA expression and plasma PCSK9 concentrations. Fatty Acids, Omega-3 8-39 proprotein convertase subtilisin/kexin type 9 Homo sapiens 105-110 28187366-1 2017 We sought to determine whether a combination of purified n-3 fatty acids (n-3) and SC-560 (SC), a cyclooxygenase-1-specific inhibitor, is effective in ameliorating nonalcoholic fatty liver disease in obesity. Fatty Acids, Omega-3 57-72 prostaglandin-endoperoxide synthase 1 Mus musculus 98-114 28356106-10 2017 These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent. Fatty Acids, Omega-3 17-48 jun proto-oncogene Mus musculus 145-150 28356106-10 2017 These effects of n-3 polyunsaturated fatty acids (PUFA) on lipid metabolism may be linked to the upregulation of Fra1 and attenuated activity of c-Jun and c-Fos, thus ultimately reducing the severity of the lipid metabolism disorder and liver damage to some extent. Fatty Acids, Omega-3 17-48 FBJ osteosarcoma oncogene Mus musculus 155-160 26704762-1 2017 OBJECTIVE: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Fatty Acids, Omega-3 95-114 interleukin 6 Homo sapiens 216-220 28272299-0 2017 Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention. Fatty Acids, Omega-3 22-40 fatty acid desaturase 1 Homo sapiens 73-78 28272299-2 2017 Our objective was to evaluate if providing information for a common variant in the fatty acid desaturase 1 (FADS1) gene changed omega-3 fatty acid (FA) intake and blood levels in young female adults (18-25 years). Fatty Acids, Omega-3 128-146 fatty acid desaturase 1 Homo sapiens 83-106 28272299-2 2017 Our objective was to evaluate if providing information for a common variant in the fatty acid desaturase 1 (FADS1) gene changed omega-3 fatty acid (FA) intake and blood levels in young female adults (18-25 years). Fatty Acids, Omega-3 128-146 fatty acid desaturase 1 Homo sapiens 108-113 28011301-5 2017 Tissue levels of omega-3 fatty acids were elevated via dietary supplementation or the fat-1 transgenic mouse model. Fatty Acids, Omega-3 17-36 FAT atypical cadherin 1 Mus musculus 86-91 28160084-2 2017 Omega-3 polyunsaturated fatty acids (N-3 PUFA) are suggested to enhance neuromuscular adaptations to exercise. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 26704762-1 2017 OBJECTIVE: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Fatty Acids, Omega-3 95-114 interleukin 6 Homo sapiens 201-214 28250850-0 2017 Effect of different concentrations of omega-3 fatty acids on stimulated THP-1 macrophages. Fatty Acids, Omega-3 38-57 GLI family zinc finger 2 Homo sapiens 72-77 28241979-7 2017 Significant changes also were identified in the biochemical analysis in NSE and TGF-beta in the brain structures; these conditions were reversed after omega-3 PUFA supplementation. Fatty Acids, Omega-3 151-158 enolase 2 Rattus norvegicus 72-75 28241979-7 2017 Significant changes also were identified in the biochemical analysis in NSE and TGF-beta in the brain structures; these conditions were reversed after omega-3 PUFA supplementation. Fatty Acids, Omega-3 151-158 transforming growth factor, beta 1 Rattus norvegicus 80-88 28241979-8 2017 CONCLUSION: Supplementation with omega-3 PUFA reversed animal behaviors that often are observed in autism and other mental disorders in rats prenatally exposed to LPS, and also exerted neuroprotective effects in marker levels of neuronal damage and expression of TGF-beta. Fatty Acids, Omega-3 33-45 transforming growth factor, beta 1 Rattus norvegicus 263-271 27664694-5 2017 The contents of CLA and n-3 FA in a serving of whole milk (3.25% fat) increased when cows grazed CSP compared to PM. Fatty Acids, Omega-3 24-30 Weaning weight-maternal milk Bos taurus 53-57 28158319-6 2017 Expressions of exogenous genes fat-1 and EGFP were detectable in 10 examined tissues and upregulated omega-3 fatty acid content. Fatty Acids, Omega-3 101-119 protocadherin Fat 1 Ovis aries 31-36 28169288-1 2017 We previously reported that eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid (n-3 PUFA), effectively inhibits sphingosylphosphorylcholine (SPC)-induced Ca2+-sensitization of vascular smooth muscle (VSM) contraction which is a major cause of cardiovascular and cerebrovascular vasospasm, and EPA is utilized clinically to prevent cerebrovascular vasospasm. Fatty Acids, Omega-3 60-94 pumilio RNA binding family member 3 Homo sapiens 100-104 28017961-0 2017 Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression. Fatty Acids, Omega-3 57-75 RB transcriptional corepressor like 2 Mus musculus 12-15 28017961-0 2017 Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression. Fatty Acids, Omega-3 57-75 free fatty acid receptor 4 Mus musculus 131-137 28017961-5 2017 Treatment with a omega-3 fatty acid alpha-linolenic acid (ALA, 50 mumol/L) produced moderate reduction in LPS-stimulated inflammatory cytokines and NO production (TNF-alpha and IL-6 were decreased by 46% and 42%, respectively). Fatty Acids, Omega-3 17-35 tumor necrosis factor Mus musculus 163-172 27927977-0 2017 PPAR mRNA Levels Are Modified by Dietary n-3 Fatty Acid Restriction and Energy Restriction in the Brain and Liver of Growing Rats. Fatty Acids, Omega-3 41-55 peroxisome proliferator activated receptor alpha Rattus norvegicus 0-4 28017961-5 2017 Treatment with a omega-3 fatty acid alpha-linolenic acid (ALA, 50 mumol/L) produced moderate reduction in LPS-stimulated inflammatory cytokines and NO production (TNF-alpha and IL-6 were decreased by 46% and 42%, respectively). Fatty Acids, Omega-3 17-35 interleukin 6 Mus musculus 177-181 28017961-10 2017 In conclusion, Rb2 exerts anti-inflammatory effect in LPS-stimulated mouse macrophage RAW264.7 cells in vitro by increasing GPR120 expression and subsequently enhancing omega-3 fatty acid-induced GPR120 activation. Fatty Acids, Omega-3 169-187 RB transcriptional corepressor like 2 Mus musculus 15-18 28017961-10 2017 In conclusion, Rb2 exerts anti-inflammatory effect in LPS-stimulated mouse macrophage RAW264.7 cells in vitro by increasing GPR120 expression and subsequently enhancing omega-3 fatty acid-induced GPR120 activation. Fatty Acids, Omega-3 169-187 free fatty acid receptor 4 Mus musculus 196-202 26611718-1 2017 BACKGROUND & AIMS: This study was carried out to evaluate the effects of omega-3 fatty acid administration on markers of insulin resistance, lipid concentrations, biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy (DN). Fatty Acids, Omega-3 77-95 insulin Homo sapiens 125-132 26611718-9 2017 CONCLUSIONS: Our findings indicated that omega-3 fatty acid administration for 12 weeks among DN patients had favorable effects on insulin levels, HOMA-B, QUICKI, serum triglycerides and VLDL-cholesterol; however, it did not influence biomarkers of inflammation and oxidative stress. Fatty Acids, Omega-3 41-59 insulin Homo sapiens 131-138 27742581-1 2017 BACKGROUND: Antidepressant efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment in coronary artery disease (CAD) patients remains unpredictable. Fatty Acids, Omega-3 39-73 pumilio RNA binding family member 3 Homo sapiens 79-83 27619403-0 2017 The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome. Fatty Acids, Omega-3 15-34 lipoprotein(a) Homo sapiens 90-104 28134235-0 2017 Effects of Different Ratio of n-6/n-3 Polyunsaturated Fatty Acids on the PI3K/Akt Pathway in Rats with Reflux Esophagitis. Fatty Acids, Omega-3 34-65 AKT serine/threonine kinase 1 Rattus norvegicus 78-81 28197106-1 2017 Recent studies suggest modulation of KCa3.1 by omega-3 fatty acids as negative modulators and impaired KCa3.1 functions in the inherited lysosomal storage disorder (LSD), Fabry disease (FD). Fatty Acids, Omega-3 47-66 potassium calcium-activated channel subfamily N member 4 Homo sapiens 37-43 28197106-6 2017 Considering modulation by omega-3 fatty acids we found that alpha-linolenic acid (alpha-LA) and docosahexanenoic acid (DHA) inhibit KCa3.1 currents and strongly reduce fibroblast growth. Fatty Acids, Omega-3 26-45 potassium calcium-activated channel subfamily N member 4 Homo sapiens 132-138 28197106-9 2017 In conclusion, the omega-3 fatty acid, alpha-LA, and alpha-LA/gamma-LA-rich plant oils, inhibit fibroblast KCa3.1 channels and mitogenesis. Fatty Acids, Omega-3 19-37 potassium calcium-activated channel subfamily N member 4 Homo sapiens 107-113 28134766-1 2017 A genome-wide association study (GWAS) by our group identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB. Fatty Acids, Omega-3 125-143 IQ motif containing J Homo sapiens 168-172 28134766-1 2017 A genome-wide association study (GWAS) by our group identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB. Fatty Acids, Omega-3 125-143 jade family PHD finger 1 Homo sapiens 181-186 28134766-1 2017 A genome-wide association study (GWAS) by our group identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB. Fatty Acids, Omega-3 125-143 MYB proto-oncogene, transcription factor Homo sapiens 191-194 28835761-0 2017 The Effect of n-3 Polyunsaturated Fatty Acids Supplementation on Serum Irisin in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial. Fatty Acids, Omega-3 14-45 fibronectin type III domain containing 5 Homo sapiens 71-77 27984084-1 2017 Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) increase insulin signaling in skeletal muscle. Fatty Acids, Omega-3 8-39 insulin Homo sapiens 61-68 27984084-1 2017 Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) increase insulin signaling in skeletal muscle. Fatty Acids, Omega-3 41-50 insulin Homo sapiens 61-68 27619403-1 2017 This study was conducted to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) (Lp[a]) and oxidized low-density lipoprotein (Ox-LDL), lipid profiles and biomarkers of oxidative stress in women with polycystic ovary syndrome (PCOS). Fatty Acids, Omega-3 53-72 lipoprotein(a) Homo sapiens 128-142 27789520-3 2017 Here, we show that n-3 polyunsaturated fatty acids (PUFAs), by use of fat-1 transgenic mice and oral administration of fish oil, significantly promote interstitial Abeta clearance from the brain and resist Abeta injury. Fatty Acids, Omega-3 19-50 FAT atypical cadherin 1 Mus musculus 70-75 25830700-2 2017 This report reviews the etiology and pathophysiology of depression, and explores the role of omega 3 polyunsaturated fatty acids (n-3 PUFA) as a possible treatment. Fatty Acids, Omega-3 93-128 pumilio RNA binding family member 3 Homo sapiens 134-138 28112528-4 2017 This study was conducted to determine the effects of Omega-3 fatty acids supplementation on serum irisin in men with coronary artery disease (CAD). Fatty Acids, Omega-3 53-72 fibronectin type III domain containing 5 Homo sapiens 98-104 28112528-15 2017 RESULTS: Compared to placebo, Omega-3 fatty acids increased serum irisin (P = 0.044) and decreased serum hs-CRP (P = 0.018) and LDL cholesterol (P = 0.031). Fatty Acids, Omega-3 30-49 fibronectin type III domain containing 5 Homo sapiens 66-72 28112528-17 2017 CONCLUSION: Omega-3 fatty acids supplementation could elevate serum irisin in male patients with CAD. Fatty Acids, Omega-3 12-31 fibronectin type III domain containing 5 Homo sapiens 68-74 29349065-11 2017 Conclusions: The reduction of urinary MCP-1 excretion in the absence of MCP-1 serum concentration may suggest a beneficial effect of omega-3 supplementation on tubular MCP-1 production. Fatty Acids, Omega-3 133-140 C-C motif chemokine ligand 2 Homo sapiens 38-43 28245764-6 2017 Omega-3 polyunsaturated fatty acids (n -3 PUFA) have been widely used in different clinical settings to counteract the deleterious effects of OS. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 42-46 27389079-2 2017 The Immune-metabolic role of omega-3 fatty acids Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA), which capable of modulating both metabolic and immune process, which may decrease pro-inflammatory cytokines, insulin resistance, and dyslipidemia. Fatty Acids, Omega-3 29-48 insulin Homo sapiens 219-226 27484441-0 2017 Effect of omega-3 fatty acids supplementation on insulin resistance in women with polycystic ovary syndrome: Meta-analysis of randomized controlled trials. Fatty Acids, Omega-3 10-29 insulin Homo sapiens 49-56 27484441-1 2017 BACKGROUND: Several studies have shown that omega-3 polyunsaturated fatty acids (PUFA) may improve insulin resistance in various diseases. Fatty Acids, Omega-3 44-79 insulin Homo sapiens 99-106 27484441-3 2017 We evaluated the effect of omega-3 PUFA supplementation on insulin resistance in women with PCOS in a meta-analysis. Fatty Acids, Omega-3 27-39 insulin Homo sapiens 59-66 27484441-5 2017 We included all randomized controlled trials (RCTs) that investigated effects of omega-3 fatty acids supplements on insulin resistance in women with PCOS. Fatty Acids, Omega-3 81-100 insulin Homo sapiens 116-123 28802305-1 2017 BACKGROUND AND OBJECTIVES: The consumption of fish and long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) may influence the risk of all-cause mortality, but the findings have been inconsistent. Fatty Acids, Omega-3 66-101 pumilio RNA binding family member 3 Homo sapiens 107-111 27306037-1 2017 BACKGROUND: Omega-3 polyunsaturated fatty acids (n-3 PUFA) are structural components of the brain and are indispensable for neuronal membrane synthesis. Fatty Acids, Omega-3 12-47 pumilio RNA binding family member 3 Homo sapiens 53-57 27677546-11 2017 Antioxidant/omega-3/resveratrol supplementation was associated with favorable immune and cognitive responses in ApoE epsilon3/epsilon3 and individual patients bearing ApoE epsilon3/epsilon4, and brings into personalized clinical practice the immune benefits expected from omega-3 mediators called resolvins. Fatty Acids, Omega-3 12-19 apolipoprotein E Homo sapiens 112-116 27677546-11 2017 Antioxidant/omega-3/resveratrol supplementation was associated with favorable immune and cognitive responses in ApoE epsilon3/epsilon3 and individual patients bearing ApoE epsilon3/epsilon4, and brings into personalized clinical practice the immune benefits expected from omega-3 mediators called resolvins. Fatty Acids, Omega-3 12-19 apolipoprotein E Homo sapiens 167-171 28502503-6 2017 CONCLUSION: Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on fasting plasma glucose, serum insulin levels, homeostatic model of assessment for insulin resistance, quantitative insulin sensitivity check index, serum triglycerides, and very low-density lipoprotein cholesterol levels. Fatty Acids, Omega-3 35-54 insulin Homo sapiens 161-168 28502503-6 2017 CONCLUSION: Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on fasting plasma glucose, serum insulin levels, homeostatic model of assessment for insulin resistance, quantitative insulin sensitivity check index, serum triglycerides, and very low-density lipoprotein cholesterol levels. Fatty Acids, Omega-3 35-54 insulin Homo sapiens 213-220 28502503-6 2017 CONCLUSION: Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on fasting plasma glucose, serum insulin levels, homeostatic model of assessment for insulin resistance, quantitative insulin sensitivity check index, serum triglycerides, and very low-density lipoprotein cholesterol levels. Fatty Acids, Omega-3 35-54 insulin Homo sapiens 213-220 28112774-1 2017 OBJECTIVE: Studies in rodents and humans have indicated that omega-3 polyunsaturated fatty acids (n-3 PUFA) may reduce weight. Fatty Acids, Omega-3 61-96 pumilio RNA binding family member 3 Homo sapiens 102-106 28104968-7 2016 Omega-3 fatty acid therapy leads to a significant elevation in adiponectin serum levels from 4.1 +- 0.99 ng/mL to 6.11 +- 1.29 ng/mL compared to control P < 0.01. Fatty Acids, Omega-3 0-18 adiponectin, C1Q and collagen domain containing Homo sapiens 63-74 29040972-6 2017 Oral administration of n-3 PUFAs had no effects on protein expressions of BK channel subunits in nondiabetic rats, but significantly enhanced those of BK-beta1 in diabetic rats without altering BK-alpha protein levels. Fatty Acids, Omega-3 23-32 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Rattus norvegicus 151-159 29017158-1 2017 OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. Fatty Acids, Omega-3 59-90 C-C motif chemokine ligand 2 Homo sapiens 127-161 29017158-1 2017 OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. Fatty Acids, Omega-3 59-90 C-C motif chemokine ligand 2 Homo sapiens 163-168 29017158-11 2017 CONCLUSIONS: The MCP-1 levels and lipid profile were improved after supplementation with n-3 PUFAs, but resistin serum levels were not changed. Fatty Acids, Omega-3 89-98 C-C motif chemokine ligand 2 Homo sapiens 17-22 29186721-1 2017 Amidst voluminous literature, inconsistencies and opposing results have confused rather than clarified cardiologists" ability to assess the potential benefits of n-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 162-193 pumilio RNA binding family member 3 Homo sapiens 199-203 29173690-1 2017 BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. Fatty Acids, Omega-3 36-55 C-reactive protein Homo sapiens 121-139 29173690-1 2017 BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. Fatty Acids, Omega-3 36-55 C-reactive protein Homo sapiens 141-144 27743986-0 2016 A combined supplementation of vitamin B12 and n-3 polyunsaturated fatty acids across two generations improves nerve growth factor and vascular endothelial growth factor levels in the rat hippocampus. Fatty Acids, Omega-3 46-77 nerve growth factor Rattus norvegicus 110-129 27743986-0 2016 A combined supplementation of vitamin B12 and n-3 polyunsaturated fatty acids across two generations improves nerve growth factor and vascular endothelial growth factor levels in the rat hippocampus. Fatty Acids, Omega-3 46-77 vascular endothelial growth factor A Rattus norvegicus 134-168 27977757-2 2016 In NAFLD, several studies have shown a benefit of omega-3 fatty acid treatment on lipid profile, insulin-sensitivity and hepatic steatosis and it has also been suggested that Vitamin D treatment has potential antifibrotic properties in liver disease. Fatty Acids, Omega-3 50-68 insulin Homo sapiens 97-104 27818127-2 2016 Recent evidence reveals that omega-3 polyunsaturated fatty acid (n-3 PUFA) precursors provide a window to explore the pathobiology of inflammatory disease as well as structural templates for the design of novel pro-resolving precursors that are well absorbed by the gastrointestinal (GI) tract and metabolized into bioactive metabolites. Fatty Acids, Omega-3 29-63 pumilio RNA binding family member 3 Homo sapiens 69-73 27663185-0 2016 Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Fatty Acids, Omega-3 50-64 interleukin 23, alpha subunit p19 Mus musculus 133-138 29083439-1 2017 OBJECTIVES: To investigate the changes in specific domains of cognitive function in older adults reporting subjective memory complaints with a low omega-3 index receiving omega 3 polyunsaturated fatty acid (n-3 PUFA) supplementation or placebo. Fatty Acids, Omega-3 171-205 pumilio RNA binding family member 3 Homo sapiens 211-215 28849990-12 2017 In brain and thorax, these omega-3 fatty acids inhibited excess H2O2 production and restored AChE activity. Fatty Acids, Omega-3 27-46 Acetylcholine esterase Drosophila melanogaster 93-97 28104968-3 2016 The aim of the present study was to evaluate the effects of rosuvastatin and/or omega-3 fatty acid on adiponectin serum levels in patients with insulin resistance (IR) and CAD. Fatty Acids, Omega-3 80-98 adiponectin, C1Q and collagen domain containing Homo sapiens 102-113 28104968-8 2016 Rosuvastatin plus omega-3 fatty acid therapy lead to a significant elevation in adiponectin serum levels from 4.1 +- 0.99 ng/mL to 7.99 +- 1.76 ng/mL compared to control P < 0.01. Fatty Acids, Omega-3 18-36 adiponectin, C1Q and collagen domain containing Homo sapiens 80-91 28104968-9 2016 CONCLUSIONS: Rosuvastatin and/or omega-3 fatty acid lead to significant cardiometabolic protection through an increment in adiponectin serum levels. Fatty Acids, Omega-3 33-51 adiponectin, C1Q and collagen domain containing Homo sapiens 123-134 27793418-0 2016 Omega-3 fatty acids decreases oxidative stress, tumor necrosis factor-alpha, and interleukin-1 beta in hyperthyroidism-induced hepatic dysfunction rat model. Fatty Acids, Omega-3 0-19 interleukin 1 beta Rattus norvegicus 81-99 27825512-8 2016 The beneficial effects of this key omega-3 fatty acid supplementation may depend on the stage of disease progression, other dietary mediators and the apolipoprotein ApoE genotype. Fatty Acids, Omega-3 35-53 apolipoprotein E Homo sapiens 150-164 27825512-8 2016 The beneficial effects of this key omega-3 fatty acid supplementation may depend on the stage of disease progression, other dietary mediators and the apolipoprotein ApoE genotype. Fatty Acids, Omega-3 35-53 apolipoprotein E Homo sapiens 165-169 27614801-6 2016 omega3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9%) and reduced systolic blood pressure (-6%) and diastolic blood pressure (-6%), plasma triglycerides (-20%), apoB concentration (-8%). Fatty Acids, Omega-3 0-9 apolipoprotein B Homo sapiens 208-212 27732914-3 2016 This raises the question of whether diets high in omega-3 fatty acids will result in a greater sensitivity or resistance to liver fibrosis as a result of environmental toxicants like CCl4. Fatty Acids, Omega-3 50-69 chemokine (C-C motif) ligand 4 Mus musculus 183-187 27732914-12 2016 Additionally, oxylipin signaling molecules may play role in the CCl4-induced liver fibrosis in the high omega-3 diet groups. Fatty Acids, Omega-3 104-111 chemokine (C-C motif) ligand 4 Mus musculus 64-68 27467133-1 2016 SCOPE: n-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with protection from obesity; however, the mechanisms of protection remain poorly characterized. Fatty Acids, Omega-3 7-37 pumilio RNA binding family member 3 Homo sapiens 43-47 27793418-5 2016 Hyperthyroid omega-3 treated group showed significantly increased final body weight and body weight gain, decreased liver weight to body weight ratio, decreased serum triiodo-l-thyronine level, increased serum thyroid stimulating hormone level, decreased serum levels of alanine transaminase, aspartate transaminase and tumor necrosis factor-alpha, increased hepatic levels of total antioxidant capacity and decreased hepatic levels of total peroxide and interleukin-1 beta when compared with the hyperthyroid group. Fatty Acids, Omega-3 13-20 interleukin 1 beta Rattus norvegicus 455-473 26611833-3 2016 Here, we report that cultured cortical neurons isolated from fat-1 mice with high endogenous n-3 PUFAs were tolerant to oxygen-glucose deprivation/reperfusion (OGD/R) injury. Fatty Acids, Omega-3 93-102 FAT atypical cadherin 1 Mus musculus 61-66 27867031-2 2016 Because n-3 polyunsaturated fatty acids (n-3 PUFA) have an antiarrhythmic effect, we hypothesized that a high content of marine n-3 PUFA in the atrial wall was associated with a reduced risk of POAF. Fatty Acids, Omega-3 8-39 pumilio RNA binding family member 3 Homo sapiens 45-49 27867031-2 2016 Because n-3 polyunsaturated fatty acids (n-3 PUFA) have an antiarrhythmic effect, we hypothesized that a high content of marine n-3 PUFA in the atrial wall was associated with a reduced risk of POAF. Fatty Acids, Omega-3 8-39 pumilio RNA binding family member 3 Homo sapiens 132-136 28461812-1 2016 BACKGROUND: Omega-3 fatty acids (O3FA) have been used to treat IgA nephropathy (IgAN) but not cutaneous IgA vasculitis (IgAV). Fatty Acids, Omega-3 12-31 IGAN1 Homo sapiens 63-78 28461812-1 2016 BACKGROUND: Omega-3 fatty acids (O3FA) have been used to treat IgA nephropathy (IgAN) but not cutaneous IgA vasculitis (IgAV). Fatty Acids, Omega-3 12-31 IGAN1 Homo sapiens 80-84 28461812-1 2016 BACKGROUND: Omega-3 fatty acids (O3FA) have been used to treat IgA nephropathy (IgAN) but not cutaneous IgA vasculitis (IgAV). Fatty Acids, Omega-3 33-37 IGAN1 Homo sapiens 63-78 28461812-1 2016 BACKGROUND: Omega-3 fatty acids (O3FA) have been used to treat IgA nephropathy (IgAN) but not cutaneous IgA vasculitis (IgAV). Fatty Acids, Omega-3 33-37 IGAN1 Homo sapiens 80-84 27523631-7 2016 Ces3/Tgh expression is regulated by omega-3 fatty acids, thus, supplementation of diet with fish oil, allowed the restoration of Ces3/Tgh expression inside the foci and, more interestingly, led to the decrease in number and volume of the AHF. Fatty Acids, Omega-3 36-55 carboxylesterase 1D Rattus norvegicus 0-4 27523631-7 2016 Ces3/Tgh expression is regulated by omega-3 fatty acids, thus, supplementation of diet with fish oil, allowed the restoration of Ces3/Tgh expression inside the foci and, more interestingly, led to the decrease in number and volume of the AHF. Fatty Acids, Omega-3 36-55 carboxylesterase 1D Rattus norvegicus 129-133 27956802-1 2016 AIM: To determine the effects of omega-3 fatty acids (omega-3FA) on the toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signal pathway in the lungs of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 33-52 toll-like receptor 4 Rattus norvegicus 72-92 27956802-1 2016 AIM: To determine the effects of omega-3 fatty acids (omega-3FA) on the toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signal pathway in the lungs of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 33-52 toll-like receptor 4 Rattus norvegicus 94-98 27956802-1 2016 AIM: To determine the effects of omega-3 fatty acids (omega-3FA) on the toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signal pathway in the lungs of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 54-63 toll-like receptor 4 Rattus norvegicus 72-92 27956802-1 2016 AIM: To determine the effects of omega-3 fatty acids (omega-3FA) on the toll-like receptor 4 (TLR4)/nuclear factor kappaB p56 (NF-kappaBp56) signal pathway in the lungs of rats with severe acute pancreatitis (SAP). Fatty Acids, Omega-3 54-63 toll-like receptor 4 Rattus norvegicus 94-98 27956802-6 2016 RESULTS: The expression of TLR4 and NF-kappaBp56 in lungs and of inflammatory cytokines in serum significantly increased in the SAP group compared with the control group (P < 0.05), but was significantly decreased in the omega-3FA group compared with the soybean oil group at 12 and 24 h (P < 0.05). Fatty Acids, Omega-3 224-233 toll-like receptor 4 Rattus norvegicus 27-31 27956802-7 2016 CONCLUSION: During the initial stage of SAP, omega-3FA can efficiently lower the inflammatory response and reduce lung injury by triggering the TLR4/NF-kappaBp56 signal pathway. Fatty Acids, Omega-3 45-54 toll-like receptor 4 Rattus norvegicus 144-148 26970335-0 2016 High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy. Fatty Acids, Omega-3 15-34 immunoglobulin heavy constant epsilon Homo sapiens 108-124 26970335-0 2016 High levels of omega-3 fatty acids in milk from omega-3 fatty acid-supplemented mothers are related to less immunoglobulin E-associated disease in infancy. Fatty Acids, Omega-3 15-33 immunoglobulin heavy constant epsilon Homo sapiens 108-124 26970335-1 2016 AIM: We previously reported a protective effect of maternal omega-3 fatty acid supplements on the development of immunoglobulin E (IgE)-associated disease in infancy. Fatty Acids, Omega-3 60-78 immunoglobulin heavy constant epsilon Homo sapiens 113-129 26970335-1 2016 AIM: We previously reported a protective effect of maternal omega-3 fatty acid supplements on the development of immunoglobulin E (IgE)-associated disease in infancy. Fatty Acids, Omega-3 60-78 immunoglobulin heavy constant epsilon Homo sapiens 131-134 27600927-0 2016 Role of beta-catenin signaling in the anti-invasive effect of the omega-3 fatty acid DHA in human melanoma cells. Fatty Acids, Omega-3 66-84 catenin beta 1 Homo sapiens 8-20 27735847-4 2016 The n-3 polyunsaturated fatty acids (n-3 PUFA), DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) exert numerous beneficial effects to maintain physiological homeostasis. Fatty Acids, Omega-3 4-35 pumilio RNA binding family member 3 Homo sapiens 41-45 27741299-9 2016 In conclusion, lipid-encapsulation provides inadequate digestibility to achieve an optimal transfer efficiency of n-3 FA to milk. Fatty Acids, Omega-3 114-120 Weaning weight-maternal milk Bos taurus 124-128 27646578-0 2016 Effects of omega-3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial. Fatty Acids, Omega-3 11-30 fatty acid synthase Homo sapiens 48-67 27522963-14 2016 O3FA similarly decreased inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), markers affiliated with monocyte activity in atherosclerosis. Fatty Acids, Omega-3 0-4 nitric oxide synthase 2 Rattus norvegicus 25-56 27522963-14 2016 O3FA similarly decreased inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), markers affiliated with monocyte activity in atherosclerosis. Fatty Acids, Omega-3 0-4 nitric oxide synthase 2 Rattus norvegicus 58-62 27522963-14 2016 O3FA similarly decreased inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), markers affiliated with monocyte activity in atherosclerosis. Fatty Acids, Omega-3 0-4 tumor necrosis factor Rattus norvegicus 65-92 27522963-14 2016 O3FA similarly decreased inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), markers affiliated with monocyte activity in atherosclerosis. Fatty Acids, Omega-3 0-4 tumor necrosis factor Rattus norvegicus 94-103 27522963-14 2016 O3FA similarly decreased inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), markers affiliated with monocyte activity in atherosclerosis. Fatty Acids, Omega-3 0-4 interleukin 6 Rattus norvegicus 110-123 27522963-14 2016 O3FA similarly decreased inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), markers affiliated with monocyte activity in atherosclerosis. Fatty Acids, Omega-3 0-4 interleukin 6 Rattus norvegicus 125-129 27529771-1 2016 This trial investigated the efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment for improving depressive symptoms and cognitive performance in patients with coronary artery disease (CAD) participating in cardiac rehabilitation. Fatty Acids, Omega-3 40-74 pumilio RNA binding family member 3 Homo sapiens 80-84 27723672-0 2016 Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD. Fatty Acids, Omega-3 29-48 adiponectin, C1Q and collagen domain containing Homo sapiens 94-105 27573698-0 2016 Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting beta-catenin signaling. Fatty Acids, Omega-3 25-40 FAT atypical cadherin 1 Mus musculus 44-49 27474750-5 2016 Previous work in our laboratory has demonstrated that free fatty acid 4 (FFA4), a GPCR activated by omega-3 fatty acids, inhibits responses to both LPA and EGF in these cells. Fatty Acids, Omega-3 100-119 epidermal growth factor Homo sapiens 156-159 27573698-0 2016 Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting beta-catenin signaling. Fatty Acids, Omega-3 25-40 cadherin 1 Mus musculus 109-119 27573698-0 2016 Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting beta-catenin signaling. Fatty Acids, Omega-3 25-40 catenin (cadherin associated protein), beta 1 Mus musculus 146-158 27474225-3 2016 Here, we employed a transgenic mice carry fat-1 gene to encode n-3 desaturase from Caenorhabditis elegans, which increase endogenous n-3 PUFAs by converting n-6 PUFAs to n-3 PUFAs crossed with amyloid precursor protein (APP) Tg mice to evaluate the protective effects of endogenous n-3 PUFAs on cognitive and behavioral deficits of APP Tg mice. Fatty Acids, Omega-3 133-142 FAT atypical cadherin 1 Mus musculus 42-47 27474225-3 2016 Here, we employed a transgenic mice carry fat-1 gene to encode n-3 desaturase from Caenorhabditis elegans, which increase endogenous n-3 PUFAs by converting n-6 PUFAs to n-3 PUFAs crossed with amyloid precursor protein (APP) Tg mice to evaluate the protective effects of endogenous n-3 PUFAs on cognitive and behavioral deficits of APP Tg mice. Fatty Acids, Omega-3 170-179 FAT atypical cadherin 1 Mus musculus 42-47 27442314-11 2016 CONCLUSIONS: Oral consumption of re-esterified omega-3 fatty acids is associated with statistically significant improvement in tear osmolarity, omega-3 index levels, TBUT, MMP-9, and OSDI symptom scores. Fatty Acids, Omega-3 47-66 matrix metallopeptidase 9 Homo sapiens 172-177 27212621-3 2016 GPR120 is activated by long chain fatty acids (FAs) including omega-3 FAs. Fatty Acids, Omega-3 62-73 free fatty acid receptor 4 Homo sapiens 0-6 27643941-0 2016 Omega-3 fatty acids reduce lipopolysaccharide-induced abnormalities in expression of connexin-40 in aorta of hereditary hypertriglyceridemic rats. Fatty Acids, Omega-3 0-19 gap junction protein, alpha 5 Rattus norvegicus 85-96 27643941-3 2016 We examined, whether 10-day omega3FA diet can reduce bacterial lipopolysaccharide-induced changes in expression of gap junction protein connexin40 (Cx40) in the aorta of hereditary hypertriglyceridemic (hHTG) rats. Fatty Acids, Omega-3 28-36 gap junction protein, alpha 5 Rattus norvegicus 136-146 27643941-3 2016 We examined, whether 10-day omega3FA diet can reduce bacterial lipopolysaccharide-induced changes in expression of gap junction protein connexin40 (Cx40) in the aorta of hereditary hypertriglyceridemic (hHTG) rats. Fatty Acids, Omega-3 28-36 gap junction protein, alpha 5 Rattus norvegicus 148-152 27643941-8 2016 Our results suggest that 10-day omega3FA diet could protect endothelium-dependent relaxation of the aorta of hHTG rats against LPS-induced damage through the modulation of endothelial Cx40 expression. Fatty Acids, Omega-3 32-40 gap junction protein, alpha 5 Rattus norvegicus 184-188 27643942-0 2016 Cardiac connexin-43 and PKC signaling in rats with altered thyroid status without and with omega-3 fatty acids intake. Fatty Acids, Omega-3 91-110 gap junction protein, alpha 1 Rattus norvegicus 8-19 27643942-0 2016 Cardiac connexin-43 and PKC signaling in rats with altered thyroid status without and with omega-3 fatty acids intake. Fatty Acids, Omega-3 91-110 protein kinase C, gamma Rattus norvegicus 24-27 27569259-4 2016 This study reports the effects of vitamin B12 and omega-3 fatty acid supplementation across three consecutive generations on brain neurotrophins like brain derived neurotrophic factor (BDNF); nerve growth factor (NGF) and cognitive performance in the third generation male offspring. Fatty Acids, Omega-3 50-68 brain-derived neurotrophic factor Rattus norvegicus 150-183 27569259-4 2016 This study reports the effects of vitamin B12 and omega-3 fatty acid supplementation across three consecutive generations on brain neurotrophins like brain derived neurotrophic factor (BDNF); nerve growth factor (NGF) and cognitive performance in the third generation male offspring. Fatty Acids, Omega-3 50-68 brain-derived neurotrophic factor Rattus norvegicus 185-189 27569259-4 2016 This study reports the effects of vitamin B12 and omega-3 fatty acid supplementation across three consecutive generations on brain neurotrophins like brain derived neurotrophic factor (BDNF); nerve growth factor (NGF) and cognitive performance in the third generation male offspring. Fatty Acids, Omega-3 50-68 nerve growth factor Rattus norvegicus 192-211 27569259-10 2016 A combined supplementation of vitamin B12 and omega-3 fatty acid showed higher (p < 0.01) levels of DHA and NGF in the hippocampus, higher BDNF in both hippocampus and cortex and improved cognitive performance. Fatty Acids, Omega-3 46-64 nerve growth factor Rattus norvegicus 111-114 27569259-10 2016 A combined supplementation of vitamin B12 and omega-3 fatty acid showed higher (p < 0.01) levels of DHA and NGF in the hippocampus, higher BDNF in both hippocampus and cortex and improved cognitive performance. Fatty Acids, Omega-3 46-64 brain-derived neurotrophic factor Rattus norvegicus 142-146 27632922-0 2016 Maternal n-3 polyunsaturated fatty acid deprivation during pregnancy and lactation affects neurogenesis and apoptosis in adult offspring: associated with DNA methylation of brain-derived neurotrophic factor transcripts. Fatty Acids, Omega-3 9-39 brain derived neurotrophic factor Mus musculus 173-206 27192695-12 2016 Higher n-3 fatty acid status was associated with lower plasma F2-IsoPs and higher plasma F3-IsoPs, which provides partial explanation to the cardioprotective effects of the n-3 PUFA-rich Inuit diet. Fatty Acids, Omega-3 7-21 pumilio RNA binding family member 3 Homo sapiens 177-181 27193109-9 2016 Omega-3 FA or isorhapontigenin significantly decreased the ST segment elevation, LDH, CK-MB, cTnI, TNF-alpha, interleukin-6, malondialdehyde, and phospholipids and increased R wave amplitude and anti-oxidants. Fatty Acids, Omega-3 0-10 troponin I3, cardiac type Rattus norvegicus 93-97 27193109-9 2016 Omega-3 FA or isorhapontigenin significantly decreased the ST segment elevation, LDH, CK-MB, cTnI, TNF-alpha, interleukin-6, malondialdehyde, and phospholipids and increased R wave amplitude and anti-oxidants. Fatty Acids, Omega-3 0-10 tumor necrosis factor Rattus norvegicus 99-108 27193109-9 2016 Omega-3 FA or isorhapontigenin significantly decreased the ST segment elevation, LDH, CK-MB, cTnI, TNF-alpha, interleukin-6, malondialdehyde, and phospholipids and increased R wave amplitude and anti-oxidants. Fatty Acids, Omega-3 0-10 interleukin 6 Rattus norvegicus 110-123 27721230-0 2016 Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. Fatty Acids, Omega-3 21-40 insulin Homo sapiens 44-51 25987421-2 2016 GPR120 is a G protein-coupled receptor for long-chain unsaturated fatty acids, including n-3 PUFAs, and was recently renamed free fatty acid receptor 4 (FFA4). Fatty Acids, Omega-3 89-98 free fatty acid receptor 4 Mus musculus 0-6 27002183-3 2016 A number of the beneficial anti-inflammatory effects credited to dietary fats such as omega-3 fatty acids are attributed to their actions on FFAR4.This might play an important protective role in the development of obesity, insulin resistance or asthma. Fatty Acids, Omega-3 86-105 free fatty acid receptor 4 Homo sapiens 141-146 27357730-0 2016 Pyruvate dehydrogenase alpha 1 as a target of omega-3 polyunsaturated fatty acids in human prostate cancer through a global phosphoproteomic analysis. Fatty Acids, Omega-3 46-81 pyruvate dehydrogenase E1 subunit alpha 1 Homo sapiens 0-30 27470381-9 2016 Increased brain MDA and TNF-alpha levels due to amphetamine were significantly reduced in groups treated with celecoxib+risperidone or omega-3+ risperidone. Fatty Acids, Omega-3 135-142 tumor necrosis factor Rattus norvegicus 24-33 27405925-0 2016 Dietary fatty acid composition is sensed by the NLRP3 inflammasome: omega-3 fatty acid (DHA) prevents NLRP3 activation in human macrophages. Fatty Acids, Omega-3 68-86 NLR family pyrin domain containing 3 Homo sapiens 48-53 27405925-0 2016 Dietary fatty acid composition is sensed by the NLRP3 inflammasome: omega-3 fatty acid (DHA) prevents NLRP3 activation in human macrophages. Fatty Acids, Omega-3 68-86 NLR family pyrin domain containing 3 Homo sapiens 102-107 27415612-0 2016 Effect of rosuvastatin or its combination with omega-3 fatty acids on circulating CD34(+) progenitor cells and on endothelial colony formation in patients with mixed dyslipidaemia. Fatty Acids, Omega-3 47-66 CD34 molecule Homo sapiens 82-86 29648713-1 2016 Study results indicate that a diet rich in polyunsaturated fatty acids omega-3 (PUFA n-3) exerts favorable effect on human health, accounting for reduced cardiovascular morbidity and mortality. Fatty Acids, Omega-3 71-78 pumilio RNA binding family member 3 Homo sapiens 80-84 28191333-8 2016 Furthermore, omega-3 fatty acid supplementation containing 180 mg of eicosapentaenoic acid (EPA) and 120 mg DHA had beneficial effects on insulin resistance in women with GDM (change from baseline: 1.5 +- 7.5 vs 3.5 +- 8.5 mIU/mL, P = 0.02) but did not influence fasting plasma glucose, homeostatic model assessment-Beta cell function (HOMA-B), the quantitative insulin sensitivity check index (QUICKI), or lipid profiles (P > 0.05). Fatty Acids, Omega-3 13-31 insulin Homo sapiens 138-145 28191333-8 2016 Furthermore, omega-3 fatty acid supplementation containing 180 mg of eicosapentaenoic acid (EPA) and 120 mg DHA had beneficial effects on insulin resistance in women with GDM (change from baseline: 1.5 +- 7.5 vs 3.5 +- 8.5 mIU/mL, P = 0.02) but did not influence fasting plasma glucose, homeostatic model assessment-Beta cell function (HOMA-B), the quantitative insulin sensitivity check index (QUICKI), or lipid profiles (P > 0.05). Fatty Acids, Omega-3 13-31 insulin Homo sapiens 362-369 27208584-0 2016 Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b(+) macrophages. Fatty Acids, Omega-3 17-48 integrin alpha M Mus musculus 151-156 27264241-6 2016 The observed omega-3 fatty acid-mediated neuroprotection is likely achieved partially through ERK1/2 signaling as inhibition of this pathway by PD98059 hindered, but did not completely block, RGC protection. Fatty Acids, Omega-3 13-31 mitogen-activated protein kinase 3 Mus musculus 94-100 27145004-0 2016 Free Fatty Acid Receptor 4 (GPR120) Stimulates Bone Formation and Suppresses Bone Resorption in the Presence of Elevated n-3 Fatty Acid Levels. Fatty Acids, Omega-3 121-135 free fatty acid receptor 4 Mus musculus 28-34 26757835-3 2016 Omega-6 polyunsaturated fatty acids (n-6PUFA) are known to compete with n-3PUFA in the metabolic pathways and for the incorporation into phospholipids, whereas saturated fats (SFA) may enhance n-3PUFA incorporation into tissues. Fatty Acids, Omega-3 72-79 pumilio RNA binding family member 3 Homo sapiens 40-44 26757835-3 2016 Omega-6 polyunsaturated fatty acids (n-6PUFA) are known to compete with n-3PUFA in the metabolic pathways and for the incorporation into phospholipids, whereas saturated fats (SFA) may enhance n-3PUFA incorporation into tissues. Fatty Acids, Omega-3 193-200 pumilio RNA binding family member 3 Homo sapiens 40-44 26021747-4 2016 In transgenic fat-1 mice with enriched omega-3 fatty acids, Abeta oligomers induced fewer neuronal losses, when compared to wild-type (WT) mice. Fatty Acids, Omega-3 39-58 FAT atypical cadherin 1 Mus musculus 14-19 27482256-1 2016 BACKGROUND AND OBJECTIVES: Statins remain the mainstay of secondary coronary artery disease (CAD) prevention, but n-3 polyunsaturated fatty acids (omega-3 PUFA) display biological effects that may also reduce the risk of atherosclerosis and CAD. Fatty Acids, Omega-3 114-145 pumilio RNA binding family member 3 Homo sapiens 155-159 27206881-10 2016 Interestingly, a small group of follow-up patients (n=9) on intervention with, a nutrient supplement, omega-3 fatty acid (a known enhancer of mitochondrial metabolism) displayed a significant improvement in the levels of plasma mtDNA, supporting our hypothesis that plasma mtDNA can be a potential monitoring or prognosis biomarker for FRDA. Fatty Acids, Omega-3 102-120 frataxin Homo sapiens 336-340 27016717-0 2016 Oleic acid, hydroxytyrosol and n-3 fatty acids collectively modulate colitis through reduction of oxidative stress and IL-8 synthesis; in vitro and in vivo studies. Fatty Acids, Omega-3 31-46 C-X-C motif chemokine ligand 8 Homo sapiens 119-123 26876435-4 2016 Here, we utilize the fat-1 transgenic mouse model, which can endogenously produce omega-3 fatty acids and thereby eliminates confounding factors of diet, to show that elevated tissue levels of omega-3 fatty acids significantly reduce body weight gain and the severity of insulin resistance, fatty liver and dyslipidemia resulting from early-life exposure to azithromycin. Fatty Acids, Omega-3 82-101 FAT atypical cadherin 1 Mus musculus 21-26 27000704-1 2016 Omega-3 fatty acids have been reported to improve neuron functions during aging and in patients affected by mild cognitive impairment, and mediate potent anti-inflammatory via G protein-coupled receptor 120 (GPR120) signal pathway. Fatty Acids, Omega-3 0-19 free fatty acid receptor 4 Homo sapiens 176-206 27000704-1 2016 Omega-3 fatty acids have been reported to improve neuron functions during aging and in patients affected by mild cognitive impairment, and mediate potent anti-inflammatory via G protein-coupled receptor 120 (GPR120) signal pathway. Fatty Acids, Omega-3 0-19 free fatty acid receptor 4 Homo sapiens 208-214 27000704-7 2016 Western blot, immunoprecipitation, and electrophoretic mobility shift assays results showed that omega-3 fatty acids effectively suppressed SAH-induced elevation of inflammatory factors, including cyclooxygenase-2, monocyte chemoattractant protein-1, and inducible nitric oxide synthase. Fatty Acids, Omega-3 97-116 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 197-213 27000704-7 2016 Western blot, immunoprecipitation, and electrophoretic mobility shift assays results showed that omega-3 fatty acids effectively suppressed SAH-induced elevation of inflammatory factors, including cyclooxygenase-2, monocyte chemoattractant protein-1, and inducible nitric oxide synthase. Fatty Acids, Omega-3 97-116 C-C motif chemokine ligand 2 Rattus norvegicus 215-249 26876435-4 2016 Here, we utilize the fat-1 transgenic mouse model, which can endogenously produce omega-3 fatty acids and thereby eliminates confounding factors of diet, to show that elevated tissue levels of omega-3 fatty acids significantly reduce body weight gain and the severity of insulin resistance, fatty liver and dyslipidemia resulting from early-life exposure to azithromycin. Fatty Acids, Omega-3 193-212 FAT atypical cadherin 1 Mus musculus 21-26 26216648-0 2016 n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial. Fatty Acids, Omega-3 0-30 insulin Homo sapiens 55-62 27000704-8 2016 In addition, omega-3 fatty acids could inhibit phosphorylation of transforming growth factor beta activated kinase-1 (TAK1), MEK4, c-Jun N-terminal kinase, and IkappaB kinase as well as activation of nuclear factor kappa B through regulating GPR120/beta-arrestin2/TAK1 binding protein-1 pathway. Fatty Acids, Omega-3 13-32 mitogen activated protein kinase kinase kinase 7 Rattus norvegicus 118-122 27000704-8 2016 In addition, omega-3 fatty acids could inhibit phosphorylation of transforming growth factor beta activated kinase-1 (TAK1), MEK4, c-Jun N-terminal kinase, and IkappaB kinase as well as activation of nuclear factor kappa B through regulating GPR120/beta-arrestin2/TAK1 binding protein-1 pathway. Fatty Acids, Omega-3 13-32 free fatty acid receptor 4 Rattus norvegicus 242-248 27000704-8 2016 In addition, omega-3 fatty acids could inhibit phosphorylation of transforming growth factor beta activated kinase-1 (TAK1), MEK4, c-Jun N-terminal kinase, and IkappaB kinase as well as activation of nuclear factor kappa B through regulating GPR120/beta-arrestin2/TAK1 binding protein-1 pathway. Fatty Acids, Omega-3 13-32 arrestin, beta 2, pseudogene Rattus norvegicus 249-263 27000704-8 2016 In addition, omega-3 fatty acids could inhibit phosphorylation of transforming growth factor beta activated kinase-1 (TAK1), MEK4, c-Jun N-terminal kinase, and IkappaB kinase as well as activation of nuclear factor kappa B through regulating GPR120/beta-arrestin2/TAK1 binding protein-1 pathway. Fatty Acids, Omega-3 13-32 TGF-beta activated kinase 1/MAP3K7 binding protein 1 Rattus norvegicus 264-286 27000704-9 2016 Furthermore, siRNA-induced GPR120 silencing blocked the protective effects of omega-3 fatty acids. Fatty Acids, Omega-3 78-97 free fatty acid receptor 4 Rattus norvegicus 27-33 27000704-10 2016 Here, we show that stimulation of GPR120 with omega-3 fatty acids pretreatment causes anti-apoptosis and anti-inflammatory effects via beta-arrestin2/TAK1 binding protein-1/TAK1 pathway in the brains of SAH rats. Fatty Acids, Omega-3 46-65 free fatty acid receptor 4 Rattus norvegicus 34-40 27000704-10 2016 Here, we show that stimulation of GPR120 with omega-3 fatty acids pretreatment causes anti-apoptosis and anti-inflammatory effects via beta-arrestin2/TAK1 binding protein-1/TAK1 pathway in the brains of SAH rats. Fatty Acids, Omega-3 46-65 arrestin, beta 2, pseudogene Rattus norvegicus 135-149 27000704-10 2016 Here, we show that stimulation of GPR120 with omega-3 fatty acids pretreatment causes anti-apoptosis and anti-inflammatory effects via beta-arrestin2/TAK1 binding protein-1/TAK1 pathway in the brains of SAH rats. Fatty Acids, Omega-3 46-65 TGF-beta activated kinase 1/MAP3K7 binding protein 1 Rattus norvegicus 150-172 27000704-10 2016 Here, we show that stimulation of GPR120 with omega-3 fatty acids pretreatment causes anti-apoptosis and anti-inflammatory effects via beta-arrestin2/TAK1 binding protein-1/TAK1 pathway in the brains of SAH rats. Fatty Acids, Omega-3 46-65 mitogen activated protein kinase kinase kinase 7 Rattus norvegicus 150-154 26216648-2 2016 n-3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance. Fatty Acids, Omega-3 0-30 pumilio RNA binding family member 3 Homo sapiens 32-36 26216648-2 2016 n-3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance. Fatty Acids, Omega-3 0-30 insulin Homo sapiens 65-72 27258299-0 2016 Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation? Fatty Acids, Omega-3 31-50 insulin Homo sapiens 0-7 27033026-0 2016 Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1alpha and serum antioxidant enzymes in patients with coronary artery disease. Fatty Acids, Omega-3 22-29 sirtuin 1 Homo sapiens 83-88 27033026-0 2016 Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1alpha and serum antioxidant enzymes in patients with coronary artery disease. Fatty Acids, Omega-3 22-29 PPARG coactivator 1 alpha Homo sapiens 93-102 27033026-2 2016 The study aimed assess the effects of coadministration of omega-3 and vitamin E supplements on SIRT1 and PGC1alpha gene expression and serum levels of antioxidant enzymes in coronary artery disease (CAD) patients. Fatty Acids, Omega-3 58-65 sirtuin 1 Homo sapiens 95-100 27033026-2 2016 The study aimed assess the effects of coadministration of omega-3 and vitamin E supplements on SIRT1 and PGC1alpha gene expression and serum levels of antioxidant enzymes in coronary artery disease (CAD) patients. Fatty Acids, Omega-3 58-65 PPARG coactivator 1 alpha Homo sapiens 105-114 27033026-10 2016 CONCLUSION: Supplementation of omega-3 fatty acids in combination with vitamin E may have beneficial effects on CAD patients by increasing gene expression of SIRT1 and PGC1alpha and improving oxidative stress and inflammation in these patients. Fatty Acids, Omega-3 31-50 sirtuin 1 Homo sapiens 158-163 27033026-10 2016 CONCLUSION: Supplementation of omega-3 fatty acids in combination with vitamin E may have beneficial effects on CAD patients by increasing gene expression of SIRT1 and PGC1alpha and improving oxidative stress and inflammation in these patients. Fatty Acids, Omega-3 31-50 PPARG coactivator 1 alpha Homo sapiens 168-177 27258299-1 2016 Omega-3 polyunsaturated fatty acids (n-3 PUFA) of marine origin, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have been long studied for their therapeutic potential in the context of type 2 diabetes, insulin resistance, and glucose homeostasis. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 27258299-1 2016 Omega-3 polyunsaturated fatty acids (n-3 PUFA) of marine origin, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have been long studied for their therapeutic potential in the context of type 2 diabetes, insulin resistance, and glucose homeostasis. Fatty Acids, Omega-3 0-35 insulin Homo sapiens 216-223 27058904-9 2016 Further work is needed to validate CCL2 as a therapeutic response biomarker for omega-3 fatty acid treatment of CRC patients. Fatty Acids, Omega-3 80-98 C-C motif chemokine ligand 2 Homo sapiens 35-39 27035283-0 2016 n-3 polyunsaturated fatty acids abrogate mTORC1/2 signaling and inhibit adrenocortical carcinoma growth in vitro and in vivo. Fatty Acids, Omega-3 0-31 CREB regulated transcription coactivator 1 Mus musculus 41-47 26776249-2 2016 Marine n-3 polyunsaturated fatty acids (n-3 PUFA), found mainly in fish and seafood, may have beneficial effects on bone and are positively associated with bone mineral density (BMD) in healthy elderly. Fatty Acids, Omega-3 7-38 pumilio RNA binding family member 3 Homo sapiens 44-48 27110821-0 2016 N-3 Polyunsaturated Fatty Acids Improve Liver Lipid Oxidation-Related Enzyme Levels and Increased the Peroxisome Proliferator-Activated Receptor alpha Expression Level in Mice Subjected to Hemorrhagic Shock/Resuscitation. Fatty Acids, Omega-3 0-31 peroxisome proliferator activated receptor alpha Mus musculus 102-150 27044314-0 2016 Effect of n-3 fatty acids on the expression of inflammatory genes in THP-1 macrophages. Fatty Acids, Omega-3 10-25 GLI family zinc finger 2 Homo sapiens 69-74 27007186-11 2016 IL-6 and TNF-alpha expressions were significantly lower in combined Ve with Omega-3 FA than treatment with Ve or Omega-3 FA alone. Fatty Acids, Omega-3 76-86 interleukin 6 Homo sapiens 0-4 26673018-5 2016 Mean CCL2 was 512.9 pg/mL (range 220-917) and positively correlated with triglycerides (r=0.45; p=0.04) and TNF-alpha (r=0.57; p=0.007) and marginally negatively correlated with fruit/vegetable intake (r=-0.42, p=0.06) and omega-3 fatty acids (r=-0.41, p=0.07). Fatty Acids, Omega-3 223-242 C-C motif chemokine ligand 2 Homo sapiens 5-9 26791484-1 2016 GPR120 (free fatty acid receptor-4) is a G protein-coupled receptor for medium- and long-chain unsaturated fatty acids, including omega-3 fatty acids. Fatty Acids, Omega-3 130-149 free fatty acid receptor 4 Homo sapiens 0-6 27136019-1 2016 Flaxseed (FS) and chia seed (CS) are oilseeds rich in omega-3 fatty acids, which may change meat and milk composition when added to ruminants" diets and may have health benefits for humans. Fatty Acids, Omega-3 54-73 chitinase acidic Homo sapiens 18-22 27007186-11 2016 IL-6 and TNF-alpha expressions were significantly lower in combined Ve with Omega-3 FA than treatment with Ve or Omega-3 FA alone. Fatty Acids, Omega-3 76-86 tumor necrosis factor Homo sapiens 9-18 27007186-11 2016 IL-6 and TNF-alpha expressions were significantly lower in combined Ve with Omega-3 FA than treatment with Ve or Omega-3 FA alone. Fatty Acids, Omega-3 113-123 interleukin 6 Homo sapiens 0-4 27007186-11 2016 IL-6 and TNF-alpha expressions were significantly lower in combined Ve with Omega-3 FA than treatment with Ve or Omega-3 FA alone. Fatty Acids, Omega-3 113-123 tumor necrosis factor Homo sapiens 9-18 26882037-1 2016 N-3 polyunsaturated fatty acids (PUFAs), especially long-chain types such as docosahexaenoic acid, are important nutrients in pregnancy, but the relationship between n-3 PUFA levels and perinatal and postnatal depression remains controversial. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 33-37 26908433-6 2016 Saturated fat intake was associated with increased CRP, sTNFRII, TNFalpha, and IL1beta, whereas eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) intake (diet or total) was associated with decreased CRP, TNFalpha, and IL1beta. Fatty Acids, Omega-3 0-13 C-reactive protein Homo sapiens 51-54 26908433-6 2016 Saturated fat intake was associated with increased CRP, sTNFRII, TNFalpha, and IL1beta, whereas eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) intake (diet or total) was associated with decreased CRP, TNFalpha, and IL1beta. Fatty Acids, Omega-3 0-13 tumor necrosis factor Homo sapiens 65-73 26908433-6 2016 Saturated fat intake was associated with increased CRP, sTNFRII, TNFalpha, and IL1beta, whereas eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) intake (diet or total) was associated with decreased CRP, TNFalpha, and IL1beta. Fatty Acids, Omega-3 0-13 interleukin 1 beta Homo sapiens 79-86 26512023-0 2016 n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus. Fatty Acids, Omega-3 0-15 proopiomelanocortin Homo sapiens 53-57 26828581-3 2016 RECENT FINDINGS: Genome-wide association study (GWAS) of Greenland Inuit shows strong adaptation signals within FADS gene cluster, attributed to high omega-3 fatty acid intake, while GWAS found ELOVL2 associated with sleep duration, age and DNA methylation. Fatty Acids, Omega-3 150-168 stearoyl-CoA desaturase Homo sapiens 112-116 27114982-0 2016 Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients. Fatty Acids, Omega-3 10-17 lipocalin 2 Homo sapiens 37-48 26638987-2 2016 Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) decrease inflammation and oxidative stress in an angiotensin II-infused apolipoprotein E-knockout (ApoE(-/-)) mouse model of AAA. Fatty Acids, Omega-3 11-46 apolipoprotein E Mus musculus 134-150 26638987-2 2016 Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) decrease inflammation and oxidative stress in an angiotensin II-infused apolipoprotein E-knockout (ApoE(-/-)) mouse model of AAA. Fatty Acids, Omega-3 11-46 apolipoprotein E Mus musculus 161-165 27114982-0 2016 Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients. Fatty Acids, Omega-3 10-17 retinol binding protein 4 Homo sapiens 53-78 27114982-2 2016 We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. Fatty Acids, Omega-3 87-106 lipocalin 2 Homo sapiens 37-42 27114982-2 2016 We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. Fatty Acids, Omega-3 87-106 retinol binding protein 4 Homo sapiens 47-52 27114982-8 2016 CONCLUSION: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM. Fatty Acids, Omega-3 51-58 retinol binding protein 4 Homo sapiens 95-100 26679763-1 2016 Short-term clinical trials of omega-3 polyunsaturated fatty acids (n-3 PUFA) as add-on therapy in patients with schizophrenia revealed mixed results. Fatty Acids, Omega-3 30-65 pumilio RNA binding family member 3 Homo sapiens 71-75 26518514-5 2016 Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Fatty Acids, Omega-3 31-50 insulin Homo sapiens 230-237 26518514-5 2016 Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Fatty Acids, Omega-3 31-50 insulin Homo sapiens 290-297 26518514-5 2016 Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Fatty Acids, Omega-3 31-50 insulin Homo sapiens 290-297 26518514-5 2016 Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Fatty Acids, Omega-3 102-121 insulin Homo sapiens 230-237 26518514-5 2016 Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Fatty Acids, Omega-3 102-121 insulin Homo sapiens 290-297 26518514-5 2016 Patients who received combined omega-3 fatty acids and vitamin E supplements compared with vitamin E, omega-3 fatty acids, and placebo had significantly decreased SGA score (p < 0.001), fasting plasma glucose (p = 0.01), serum insulin levels (p = 0.001), homeostasis model of assessment insulin resistance (p = 0.002), and improved quantitative insulin sensitivity check index (p = 0.006). Fatty Acids, Omega-3 102-121 insulin Homo sapiens 290-297 26370400-6 2016 RESULTS: Anti-CCP2 positive cases were less likely than controls to report omega-3 FA supplement use (odds ratio: 0.14; 95% CI 0.03, 0.68). Fatty Acids, Omega-3 75-85 AGBL carboxypeptidase 2 Homo sapiens 14-18 26370400-7 2016 In addition, the likelihood of anti-CCP2 positivity was inversely associated with total omega-3 FA % in RBCs (odds ratio: 0.47; 95% CI 0.24, 0.92, for a s.d. Fatty Acids, Omega-3 88-98 AGBL carboxypeptidase 2 Homo sapiens 36-40 26370400-9 2016 CONCLUSION: The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA. Fatty Acids, Omega-3 83-93 AGBL carboxypeptidase 2 Homo sapiens 49-53 26370400-9 2016 CONCLUSION: The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA. Fatty Acids, Omega-3 113-123 AGBL carboxypeptidase 2 Homo sapiens 49-53 26821052-7 2016 The n-3 fatty acid eicosopentaneoic acid inhibited LPA- and EGF-induced proliferation in both cell lines. Fatty Acids, Omega-3 4-18 epidermal growth factor Homo sapiens 60-63 26856322-0 2016 n-3 Polyunsaturated Fatty Acids Improve Inflammation via Inhibiting Sphingosine Kinase 1 in a Rat Model of Parenteral Nutrition and CLP-Induced Sepsis. Fatty Acids, Omega-3 0-31 sphingosine kinase 1 Rattus norvegicus 68-88 26856322-15 2016 In conclusion, the anti-inflammatory effect of n-3 PUFA may be linked to the inhibition of the SphK1/S1P pathway in a rat model of parenteral nutrition and CLP-induced sepsis. Fatty Acids, Omega-3 47-55 sphingosine kinase 1 Rattus norvegicus 95-100 26821052-10 2016 The results indicate that n-3 fatty acids inhibit breast cancer cell proliferation via FFARs, and suggest a mechanism involving negative cross-talk between FFARS, LPA receptors, and EGF receptor. Fatty Acids, Omega-3 26-41 epidermal growth factor receptor Homo sapiens 182-194 26577021-2 2016 Dietary omega-3 fatty acids are known to possess antilipidemic properties, which could be mediated by activation of PPAR family transcription factors. Fatty Acids, Omega-3 8-27 peroxisome proliferator activated receptor alpha Homo sapiens 116-120 26476105-0 2016 n-3 polyunsaturated fatty acids suppress CD4(+) T cell proliferation by altering phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2] organization. Fatty Acids, Omega-3 0-31 CD4 antigen Mus musculus 41-44 26474750-7 2016 Overall, fat1-overexpression resulted in an increase in the n-3 fatty acids and altered expression of PUFA synthesis related genes in GEFCs. Fatty Acids, Omega-3 60-75 protocadherin Fat 1 Capra hircus 9-13 26551407-1 2016 BACKGROUND: A number of randomised controlled trials report a beneficial effect of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on emotional lability (EL) and related domains (e.g. oppositional behaviour, conduct problems). Fatty Acids, Omega-3 83-117 pumilio RNA binding family member 3 Homo sapiens 123-127 26754658-12 2016 Reducing FABP4 level might be involved in suppression of cardiovascular events by omega-3 fatty acids. Fatty Acids, Omega-3 82-101 fatty acid binding protein 4 Homo sapiens 9-14 26754658-8 2016 Change in FABP4 level by omega-3 fatty acids was negatively correlated with change in levels of EPA + DHA (r = -0.643, P = 0.013), EPA (r = -0.540, P = 0.046) and DHA (r = -0.650, P = 0.011) but not change in the level of triglycerides or other fatty acid composition. Fatty Acids, Omega-3 25-44 fatty acid binding protein 4 Homo sapiens 10-15 26754658-11 2016 CONCLUSIONS: Omega-3 fatty acids decrease circulating FABP4 level, possibly by reducing expression and consecutive secretion of FABP4 in adipocytes. Fatty Acids, Omega-3 13-32 fatty acid binding protein 4 Homo sapiens 54-59 26754658-11 2016 CONCLUSIONS: Omega-3 fatty acids decrease circulating FABP4 level, possibly by reducing expression and consecutive secretion of FABP4 in adipocytes. Fatty Acids, Omega-3 13-32 fatty acid binding protein 4 Homo sapiens 128-133 26476105-2 2016 We have previously demonstrated that n-3 PUFA decrease the amount of phosphatidylinositol-(4,5)-bisphosphate, [PI(4,5)P2], in CD4(+) T cells, leading to suppressed actin remodeling upon activation. Fatty Acids, Omega-3 37-45 CD4 antigen Mus musculus 126-129 26237277-1 2016 Evidence for the health-promoting effects of food rich in n-3 polyunsaturated fatty acids (n-3 PUFA) is reviewed. Fatty Acids, Omega-3 58-89 pumilio RNA binding family member 3 Homo sapiens 95-99 26683215-7 2016 A diet low in n-3 polyunsaturated fatty acids, as well as the presence of genetic factors, may induce a reduction in the GRP120 signal and the activation of Kupffer cells and inflammation during NAFLD. Fatty Acids, Omega-3 14-45 free fatty acid receptor 4 Homo sapiens 121-127 27041244-3 2016 We studied the effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in the VEGF and IL-8 plasma levels in patients with mixed dyslipidaemia. Fatty Acids, Omega-3 90-125 vascular endothelial growth factor A Homo sapiens 149-153 27041244-3 2016 We studied the effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in the VEGF and IL-8 plasma levels in patients with mixed dyslipidaemia. Fatty Acids, Omega-3 90-125 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 27041244-3 2016 We studied the effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in the VEGF and IL-8 plasma levels in patients with mixed dyslipidaemia. Fatty Acids, Omega-3 127-140 vascular endothelial growth factor A Homo sapiens 149-153 27041244-3 2016 We studied the effect of rosuvastatin monotherapy or its combination at a lower dose with omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in the VEGF and IL-8 plasma levels in patients with mixed dyslipidaemia. Fatty Acids, Omega-3 127-140 C-X-C motif chemokine ligand 8 Homo sapiens 158-162 27041244-11 2016 CONCLUSIONS: We show for the first time that either rosuvastatin monotherapy or its combination at a lower dose with omega-3 PUFAs reduces IL-8 levels in mixed dyslipidaemic patients. Fatty Acids, Omega-3 117-124 C-X-C motif chemokine ligand 8 Homo sapiens 139-143 26391044-2 2016 The suppressive effect of n-3 polyunsaturated fatty acids (n-3 PUFA) against oxidative/nitrosative stressinduced injury in nervous tissues has recently received increasing interest. Fatty Acids, Omega-3 26-57 pumilio RNA binding family member 3 Homo sapiens 63-67 27313878-5 2016 Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a Th2 phenotype and increasing insulin sensitivity. Fatty Acids, Omega-3 8-39 negative elongation factor complex member C/D Homo sapiens 94-97 27313878-5 2016 Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a Th2 phenotype and increasing insulin sensitivity. Fatty Acids, Omega-3 8-39 insulin Homo sapiens 144-151 27999451-1 2016 Free fatty acid receptor-4 (FFAR4), also known as GPR120, has been reported to mediate the beneficial effects of omega-3 polyunsaturated fatty acids (omega3-PUFAs) by inducing an anti-inflammatory immune response. Fatty Acids, Omega-3 113-148 free fatty acid receptor 4 Mus musculus 0-26 27057523-0 2016 Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients. Fatty Acids, Omega-3 10-17 lipocalin 2 Homo sapiens 37-48 27057523-0 2016 Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients. Fatty Acids, Omega-3 10-17 retinol binding protein 4 Homo sapiens 53-78 27057523-2 2016 We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. Fatty Acids, Omega-3 87-106 lipocalin 2 Homo sapiens 37-42 27057523-2 2016 We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. Fatty Acids, Omega-3 87-106 retinol binding protein 4 Homo sapiens 47-52 27057523-8 2016 CONCLUSIONS: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM. Fatty Acids, Omega-3 52-59 retinol binding protein 4 Homo sapiens 96-101 26662277-0 2016 Dietary Omega-3 Fatty Acids Prevented Adipocyte Hypertrophy by Downregulating DGAT-2 and FABP-4 in a Sex-Dependent Fashion. Fatty Acids, Omega-3 8-27 diacylglycerol O-acyltransferase 2 Mus musculus 78-84 26662277-0 2016 Dietary Omega-3 Fatty Acids Prevented Adipocyte Hypertrophy by Downregulating DGAT-2 and FABP-4 in a Sex-Dependent Fashion. Fatty Acids, Omega-3 8-27 fatty acid binding protein 4, adipocyte Mus musculus 89-95 27999451-1 2016 Free fatty acid receptor-4 (FFAR4), also known as GPR120, has been reported to mediate the beneficial effects of omega-3 polyunsaturated fatty acids (omega3-PUFAs) by inducing an anti-inflammatory immune response. Fatty Acids, Omega-3 113-148 free fatty acid receptor 4 Mus musculus 28-33 27999451-1 2016 Free fatty acid receptor-4 (FFAR4), also known as GPR120, has been reported to mediate the beneficial effects of omega-3 polyunsaturated fatty acids (omega3-PUFAs) by inducing an anti-inflammatory immune response. Fatty Acids, Omega-3 113-148 free fatty acid receptor 4 Mus musculus 50-56 27999451-1 2016 Free fatty acid receptor-4 (FFAR4), also known as GPR120, has been reported to mediate the beneficial effects of omega-3 polyunsaturated fatty acids (omega3-PUFAs) by inducing an anti-inflammatory immune response. Fatty Acids, Omega-3 150-162 free fatty acid receptor 4 Mus musculus 0-26 27999451-1 2016 Free fatty acid receptor-4 (FFAR4), also known as GPR120, has been reported to mediate the beneficial effects of omega-3 polyunsaturated fatty acids (omega3-PUFAs) by inducing an anti-inflammatory immune response. Fatty Acids, Omega-3 150-162 free fatty acid receptor 4 Mus musculus 28-33 27999451-1 2016 Free fatty acid receptor-4 (FFAR4), also known as GPR120, has been reported to mediate the beneficial effects of omega-3 polyunsaturated fatty acids (omega3-PUFAs) by inducing an anti-inflammatory immune response. Fatty Acids, Omega-3 150-162 free fatty acid receptor 4 Mus musculus 50-56 26709868-0 2016 Association between omega-3 fatty acids and serum prostate-specific antigen. Fatty Acids, Omega-3 20-39 kallikrein related peptidase 3 Homo sapiens 50-75 26709868-1 2016 We examined the association between omega-3 fatty acids (O3FAs) and prostate-specific antigen (PSA) in a cross-sectional analysis of 6219 men examined at the Cooper Clinic from 2009 to 2013. Fatty Acids, Omega-3 36-55 kallikrein related peptidase 3 Homo sapiens 68-99 26802939-0 2016 Supplementation of maternal omega-3 fatty acids to pregnancy induced hypertension Wistar rats improves IL10 and VEGF levels. Fatty Acids, Omega-3 28-47 interleukin 10 Rattus norvegicus 103-107 27891208-0 2016 Endogenous n-3 Fatty Acids Alleviate Carbon-Tetrachloride-Induced Acute Liver Injury in Fat-1 Transgenic Mice. Fatty Acids, Omega-3 11-26 FAT atypical cadherin 1 Mus musculus 88-93 27891208-5 2016 Endogenous n-3 PUFA decreased the elevation of oxidative stress induced by CCl4 challenge, which might be attributed to the activation of Nrf2/keap1 pathway. Fatty Acids, Omega-3 11-19 chemokine (C-C motif) ligand 4 Mus musculus 75-79 27891208-5 2016 Endogenous n-3 PUFA decreased the elevation of oxidative stress induced by CCl4 challenge, which might be attributed to the activation of Nrf2/keap1 pathway. Fatty Acids, Omega-3 11-19 nuclear factor, erythroid derived 2, like 2 Mus musculus 138-142 27891208-5 2016 Endogenous n-3 PUFA decreased the elevation of oxidative stress induced by CCl4 challenge, which might be attributed to the activation of Nrf2/keap1 pathway. Fatty Acids, Omega-3 11-19 kelch-like ECH-associated protein 1 Mus musculus 143-148 26802939-0 2016 Supplementation of maternal omega-3 fatty acids to pregnancy induced hypertension Wistar rats improves IL10 and VEGF levels. Fatty Acids, Omega-3 28-47 vascular endothelial growth factor A Rattus norvegicus 112-116 26802939-10 2016 In contrast individual omega-3 fatty acid as well as combined micronutrient supplementation showed IL-10 and VEGF levels comparable to that of control. Fatty Acids, Omega-3 23-41 interleukin 10 Rattus norvegicus 99-104 26802939-10 2016 In contrast individual omega-3 fatty acid as well as combined micronutrient supplementation showed IL-10 and VEGF levels comparable to that of control. Fatty Acids, Omega-3 23-41 vascular endothelial growth factor A Rattus norvegicus 109-113 26321228-8 2015 Western blotting showed that omega-3 supplementation precluded the CBS protein increase detected in 10-month-old controls but also produced an increase in BHMT protein levels. Fatty Acids, Omega-3 29-36 betaine-homocysteine methyltransferase Mus musculus 155-159 26672987-0 2015 Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. Fatty Acids, Omega-3 188-206 prostaglandin-endoperoxide synthase 1 Homo sapiens 11-16 26672987-0 2015 Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. Fatty Acids, Omega-3 188-206 arachidonate 12-lipoxygenase, 12S type Homo sapiens 21-27 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 prostaglandin-endoperoxide synthase 1 Homo sapiens 88-125 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 prostaglandin-endoperoxide synthase 1 Homo sapiens 127-132 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 135-172 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 174-179 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 arachidonate 12-lipoxygenase, 12S type Homo sapiens 182-210 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 arachidonate 12-lipoxygenase, 12S type Homo sapiens 212-218 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 C-X-C motif chemokine ligand 8 Homo sapiens 225-238 26672987-5 2015 RESULTS: Healthy individuals supplemented with omega-3 FA had differential responses in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), arachidonate 12-lipoxygenase (ALOX12), and interleukin 8 (IL-8) gene expression in isolated PBMCs. Fatty Acids, Omega-3 47-57 C-X-C motif chemokine ligand 8 Homo sapiens 240-244 26672987-6 2015 In those individuals for whom plasma arachidonic acid (ARA) in the phosphatidylethanolamine (PE) lipid class decreased in response to omega-3 intervention, there was a corresponding decrease in gene expression for PTGS1 and ALOX12. Fatty Acids, Omega-3 134-141 prostaglandin-endoperoxide synthase 1 Homo sapiens 214-219 26672987-6 2015 In those individuals for whom plasma arachidonic acid (ARA) in the phosphatidylethanolamine (PE) lipid class decreased in response to omega-3 intervention, there was a corresponding decrease in gene expression for PTGS1 and ALOX12. Fatty Acids, Omega-3 134-141 arachidonate 12-lipoxygenase, 12S type Homo sapiens 224-230 26790385-0 2015 Omega-3 Polyunsaturated Fatty Acids May Attenuate Streptozotocin-Induced Pancreatic beta-Cell Death via Autophagy Activation in Fat1 Transgenic Mice. Fatty Acids, Omega-3 0-35 FAT atypical cadherin 1 Mus musculus 128-132 26852691-11 2015 The simultaneous administration of Mesna and n-3 PUFAs is particularly effective in ameliorating DSS colitis in rats, by reducing oxidative stress, inflammation and apoptosis, probably through a mechanism that involves the inhibition of NF-kappaB and overexpression of iNOS. Fatty Acids, Omega-3 45-54 nitric oxide synthase 2 Rattus norvegicus 269-273 26143741-0 2016 Marine n-3 polyunsaturated fatty acids lower plasma proprotein convertase subtilisin kexin type 9 levels in pre- and postmenopausal women: A randomised study. Fatty Acids, Omega-3 7-38 proprotein convertase subtilisin/kexin type 9 Homo sapiens 52-97 26143741-1 2016 OBJECTIVE: To investigate whether a supplement of 2.2g of marine n-3 polyunsaturated fatty acids (PUFA) influences plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in pre- and postmenopausal women. Fatty Acids, Omega-3 65-96 proprotein convertase subtilisin/kexin type 9 Homo sapiens 122-167 26143741-1 2016 OBJECTIVE: To investigate whether a supplement of 2.2g of marine n-3 polyunsaturated fatty acids (PUFA) influences plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in pre- and postmenopausal women. Fatty Acids, Omega-3 65-96 proprotein convertase subtilisin/kexin type 9 Homo sapiens 169-174 27803479-4 2016 Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, potentiates IL-1beta-induced iNOS and COX-2 expression in VSMCs isolated from WKY, but not those from SHRSP. Fatty Acids, Omega-3 31-61 interleukin 1 beta Rattus norvegicus 75-83 26327595-6 2015 Here we demonstrate that the n-3 PUFA docosahexaenoic acid (DHA; 22:5 n-3) reduces nSREBP-1c by inhibiting regulated intramembrane proteolysis (RIP) of the nascent SREBP-1c. Fatty Acids, Omega-3 29-37 sterol regulatory element binding transcription factor 1 Rattus norvegicus 84-92 26327595-9 2015 We have defined a novel regulatory mechanism by which n-3 PUFA inhibit induction of SREBP-1c by insulin. Fatty Acids, Omega-3 54-62 sterol regulatory element binding transcription factor 1 Rattus norvegicus 84-92 26363927-4 2015 The fat-1 mice express fatty acid n-3 desaturase and produce endogenous n-3 PUFA. Fatty Acids, Omega-3 72-80 FAT atypical cadherin 1 Mus musculus 4-9 26402697-0 2015 Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal. Fatty Acids, Omega-3 11-42 C-C motif chemokine ligand 2 Rattus norvegicus 46-51 26675329-0 2015 A low ratio of n-6/n-3 polyunsaturated fatty acids suppresses matrix metalloproteinase 13 expression and reduces adjuvant-induced arthritis in rats. Fatty Acids, Omega-3 19-50 matrix metallopeptidase 13 Rattus norvegicus 62-89 26637972-2 2015 We evaluated whether the high endogenous levels of omega-3 polyunsaturated acids (n-3 PUFA) in fat-1 transgenic mice could protect them against acute ethanol-induced liver steatosis. Fatty Acids, Omega-3 82-90 FAT atypical cadherin 1 Mus musculus 95-100 26303404-0 2015 n-3 polyunsaturated fatty acids stimulate osteoclastogenesis through PPARgamma-mediated enhancement of c-Fos expression, and suppress osteoclastogenesis through PPARgamma-dependent inhibition of NFkB activation. Fatty Acids, Omega-3 0-31 peroxisome proliferator activated receptor gamma Homo sapiens 69-78 26303404-0 2015 n-3 polyunsaturated fatty acids stimulate osteoclastogenesis through PPARgamma-mediated enhancement of c-Fos expression, and suppress osteoclastogenesis through PPARgamma-dependent inhibition of NFkB activation. Fatty Acids, Omega-3 0-31 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 26303404-0 2015 n-3 polyunsaturated fatty acids stimulate osteoclastogenesis through PPARgamma-mediated enhancement of c-Fos expression, and suppress osteoclastogenesis through PPARgamma-dependent inhibition of NFkB activation. Fatty Acids, Omega-3 0-31 peroxisome proliferator activated receptor gamma Homo sapiens 161-170 26291662-1 2015 We have previously demonstrated that treating diabetic rats with enalapril, an angiotensin converting enzyme (ACE) inhibitor, alpha-lipoic acid, an antioxidant, or menhaden oil, a natural source of omega-3 fatty acids can partially improve diabetic peripheral neuropathy. Fatty Acids, Omega-3 198-217 angiotensin I converting enzyme Rattus norvegicus 79-108 26291662-1 2015 We have previously demonstrated that treating diabetic rats with enalapril, an angiotensin converting enzyme (ACE) inhibitor, alpha-lipoic acid, an antioxidant, or menhaden oil, a natural source of omega-3 fatty acids can partially improve diabetic peripheral neuropathy. Fatty Acids, Omega-3 198-217 angiotensin I converting enzyme Rattus norvegicus 110-113 26275932-5 2015 The aim of the current study was to assess the effects of dietary omega-3 fatty acid supplementation on FFAR4 expression in the rat colon. Fatty Acids, Omega-3 66-84 free fatty acid receptor 4 Rattus norvegicus 104-109 26275932-9 2015 CONCLUSIONS: These results suggest that similar to ingestion of other fats, dietary-intake of omega-3 fatty acids can alter FFAR4 expression within the colon. Fatty Acids, Omega-3 94-113 free fatty acid receptor 4 Rattus norvegicus 124-129 26374481-0 2015 n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling. Fatty Acids, Omega-3 0-31 AKT serine/threonine kinase 1 Rattus norvegicus 124-127 26374481-12 2015 In addition, n-3 PUFAs promote the formation of membrane phosphatidylserine, thereby promoting Akt activity and improving cellular survival. Fatty Acids, Omega-3 13-22 AKT serine/threonine kinase 1 Rattus norvegicus 95-98 25604769-1 2015 BACKGROUND AND OBJECTIVES: The aim of this study was, first, to investigate the effect of omega 3 (omega3) fatty acids plus low-dose aspirin with closed debridement in the treatment of patients with periodontitis and type 2 diabetes mellitus (DM), and second, to estimate the expression of monocyte chemoattractant protein-3 (MCP-3) in response to the supposed modulatory therapy. Fatty Acids, Omega-3 90-118 C-C motif chemokine ligand 7 Homo sapiens 290-324 25604769-1 2015 BACKGROUND AND OBJECTIVES: The aim of this study was, first, to investigate the effect of omega 3 (omega3) fatty acids plus low-dose aspirin with closed debridement in the treatment of patients with periodontitis and type 2 diabetes mellitus (DM), and second, to estimate the expression of monocyte chemoattractant protein-3 (MCP-3) in response to the supposed modulatory therapy. Fatty Acids, Omega-3 90-118 C-C motif chemokine ligand 7 Homo sapiens 326-331 26494286-7 2015 Dietary enrichment in omega-3 fatty acids during pregnancy and lactation in mice, which permanently reduces endocannabinoid levels in the offspring, phenocopies CB1R(-/-) islet microstructure and improves coordinated hormone secretion. Fatty Acids, Omega-3 22-41 cannabinoid receptor 1 (brain) Mus musculus 161-165 24214970-1 2015 OBJECTIVE: To investigate effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on attention, literacy, and behavior in children with ADHD. Fatty Acids, Omega-3 37-72 pumilio RNA binding family member 3 Homo sapiens 78-82 26318793-6 2015 We have also analyzed the effect of a chronic treatment of these rats with omega-3 fatty acid in CRP and cytokine levels, during an epileptic focus generation. Fatty Acids, Omega-3 75-93 C-reactive protein Rattus norvegicus 97-100 26318793-8 2015 We found reduced levels of CRP and all proinflammatory cytokines in the blood of animals with chronic seizures, treated with omega-3, when compared with those treated with vehicle solution. Fatty Acids, Omega-3 125-132 C-reactive protein Rattus norvegicus 27-30 25326195-1 2015 PURPOSE: Fish and rapeseed oil are major sources of omega-3 polyunsaturated fatty acids (n-3 PUFA) in complementary food, but little is known about current consumption in Germany. Fatty Acids, Omega-3 52-87 pumilio RNA binding family member 3 Homo sapiens 93-97 25900100-9 2015 These data suggest that the ER is an important site of adiponectin accumulation and that treatment with long chain omega-3 fatty acids increases adiponectin release. Fatty Acids, Omega-3 115-134 adiponectin, C1Q and collagen domain containing Homo sapiens 145-156 25096818-0 2015 Omega-3 fatty acids" effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial. Fatty Acids, Omega-3 0-19 leptin Homo sapiens 31-37 25416681-6 2015 The 150 g servings of baked and pickled herring provided 3.3 and 2.8 g of long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA), respectively, which was reflected in a substantial postprandial increase in plasma LC n-3 PUFA levels. Fatty Acids, Omega-3 85-116 pumilio RNA binding family member 3 Homo sapiens 125-129 26194111-8 2015 CONCLUSION: n-3 Polyunsaturated fatty acids are potent anti-inflammatory and pro-resolution products of 15-LOX-1 that can potentially prevent colitis-associated colorectal cancer and colorectal cancer. Fatty Acids, Omega-3 12-43 arachidonate 15-lipoxygenase Homo sapiens 104-112 25096818-0 2015 Omega-3 fatty acids" effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial. Fatty Acids, Omega-3 0-19 adiponectin, C1Q and collagen domain containing Homo sapiens 42-53 25096818-1 2015 CONTEXT: Omega-3 fatty acids have been recently proposed to induce neural improvement in patients with spinal cord injury (SCI) while affecting some hormones including leptin and adiponectin. Fatty Acids, Omega-3 9-28 leptin Homo sapiens 168-174 25096818-1 2015 CONTEXT: Omega-3 fatty acids have been recently proposed to induce neural improvement in patients with spinal cord injury (SCI) while affecting some hormones including leptin and adiponectin. Fatty Acids, Omega-3 9-28 adiponectin, C1Q and collagen domain containing Homo sapiens 179-190 25096818-2 2015 OBJECTIVES: We tried to evaluate the effect of omega-3 fatty acids on circulatory concentrations of leptin and adiponectin among these patients. Fatty Acids, Omega-3 47-66 leptin Homo sapiens 100-106 25096818-2 2015 OBJECTIVES: We tried to evaluate the effect of omega-3 fatty acids on circulatory concentrations of leptin and adiponectin among these patients. Fatty Acids, Omega-3 47-66 adiponectin, C1Q and collagen domain containing Homo sapiens 111-122 26268565-1 2015 BACKGROUND: The body is dependent on the exogenous supply of omega-3 polyunsaturated fatty acids (n3-PUFA). Fatty Acids, Omega-3 61-96 pumilio RNA binding family member 3 Homo sapiens 101-105 26219838-1 2015 The n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) have been reported to improve obesity-associated metabolic disorders including chronic inflammation, insulin resistance and dyslipidaemia. Fatty Acids, Omega-3 48-57 insulin Homo sapiens 217-224 26308008-1 2015 Algae contain a number of anti-inflammatory bioactive compounds such as omega-3 polyunsaturated fatty acids (n-3 PUFA) and chlorophyll a, hence as dietary ingredients, their extracts may be effective in chronic inflammation-linked metabolic diseases such as cardiovascular disease. Fatty Acids, Omega-3 72-107 pumilio RNA binding family member 3 Homo sapiens 113-117 26282560-1 2015 BACKGROUND: Diets rich in the n-3 fatty acid alpha-linolenic acid (ALA) have been shown to reduce breast tumor growth, enhance the effectiveness of the HER2-targeted drug trastuzumab (TRAS) and reduce HER2 signaling in mouse models. Fatty Acids, Omega-3 30-44 erb-b2 receptor tyrosine kinase 2 Mus musculus 152-156 26282560-1 2015 BACKGROUND: Diets rich in the n-3 fatty acid alpha-linolenic acid (ALA) have been shown to reduce breast tumor growth, enhance the effectiveness of the HER2-targeted drug trastuzumab (TRAS) and reduce HER2 signaling in mouse models. Fatty Acids, Omega-3 30-44 erb-b2 receptor tyrosine kinase 2 Mus musculus 201-205 26197477-4 2015 Dietary n-3 fatty acids supplements may change the developing immune system of the newborn before allergic responses are established, particularly for those with a genetic predisposition to the production of the immunoglobulin E (IgE) antibody. Fatty Acids, Omega-3 8-23 immunoglobulin heavy constant epsilon Homo sapiens 212-228 25913736-1 2015 SCOPE: Omega-3 polyunsaturated fatty acids (n-3 PUFA) found in fish oil activate PPAR-alpha, stimulate peroxisomal fatty acid (FA) beta-oxidation and prevent impairments on glucose homeostasis. Fatty Acids, Omega-3 7-42 peroxisome proliferator activated receptor alpha Mus musculus 81-91 25913736-1 2015 SCOPE: Omega-3 polyunsaturated fatty acids (n-3 PUFA) found in fish oil activate PPAR-alpha, stimulate peroxisomal fatty acid (FA) beta-oxidation and prevent impairments on glucose homeostasis. Fatty Acids, Omega-3 44-52 peroxisome proliferator activated receptor alpha Mus musculus 81-91 26197477-4 2015 Dietary n-3 fatty acids supplements may change the developing immune system of the newborn before allergic responses are established, particularly for those with a genetic predisposition to the production of the immunoglobulin E (IgE) antibody. Fatty Acids, Omega-3 8-23 immunoglobulin heavy constant epsilon Homo sapiens 230-233 25220417-8 2015 Although some anti-inflammatory effects of omega-3 PUFAs were previously shown to be mediated by the G-protein-coupled receptor 120 (GPR120), the FOD reduced Py230 tumor burden in GPR120-deficient mice to a similar degree as observed in wild-type mice, indicating that the effect of FOD to reduce tumor growth does not require GPR120 in the host mouse. Fatty Acids, Omega-3 43-56 free fatty acid receptor 4 Mus musculus 101-131 26184176-0 2015 Does Short-Term Dietary Omega-3 Fatty Acid Supplementation Influence Brain Hippocampus Gene Expression of Zinc Transporter-3? Fatty Acids, Omega-3 24-42 solute carrier family 30 (zinc transporter), member 3 Mus musculus 106-124 26184176-7 2015 The results showed that 3 weeks of dietary omega-3 fatty acid supplementation improved cognitive performance along with the up-regulation of alpha-synuclein, calmodulin and transthyretin genes expression. Fatty Acids, Omega-3 43-61 synuclein, alpha Mus musculus 141-156 26184176-7 2015 The results showed that 3 weeks of dietary omega-3 fatty acid supplementation improved cognitive performance along with the up-regulation of alpha-synuclein, calmodulin and transthyretin genes expression. Fatty Acids, Omega-3 43-61 calmodulin 2 Mus musculus 158-168 26184176-8 2015 In addition, dietary omega-3 fatty acid deficiency increased the level of ZnT3 gene and subsequently reduced cognitive performance in mice. Fatty Acids, Omega-3 21-39 solute carrier family 30 (zinc transporter), member 3 Mus musculus 74-78 26184176-9 2015 These results indicate that the increased the ZnT3 levels caused by the deficiency of omega-3 fatty acids produced an abnormal zinc metabolism that in turn impaired the brain cognitive performance in mice. Fatty Acids, Omega-3 86-105 solute carrier family 30 (zinc transporter), member 3 Mus musculus 46-50 26005911-1 2015 AIM: Free fatty acid receptor 4 (FFA4; formerly known as GPR120) is the G protein-coupled receptor (GPCR) for omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 110-145 free fatty acid receptor 4 Homo sapiens 57-63 25852206-0 2015 Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans. Fatty Acids, Omega-3 19-34 insulin Homo sapiens 61-68 25852206-1 2015 OBJECTIVE: Dietary n-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevent insulin resistance and stimulate mitochondrial biogenesis in rodents, but the findings of translational studies in humans are thus far ambiguous. Fatty Acids, Omega-3 19-50 insulin Homo sapiens 130-137 25934765-5 2015 We found that a omega-3 fatty acid diet: (i) normalizes red cell membrane omega-6/omega-3 ratio; (ii) reduces neutrophil count; (iii) decreases endothelial activation by targeting endothelin-1 and (iv) improves left ventricular outflow tract dimensions. Fatty Acids, Omega-3 16-34 endothelin 1 Mus musculus 180-192 25934765-5 2015 We found that a omega-3 fatty acid diet: (i) normalizes red cell membrane omega-6/omega-3 ratio; (ii) reduces neutrophil count; (iii) decreases endothelial activation by targeting endothelin-1 and (iv) improves left ventricular outflow tract dimensions. Fatty Acids, Omega-3 16-23 endothelin 1 Mus musculus 180-192 25910895-0 2015 Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids attenuates K/BxN serum-transfer arthritis in fat-1 mice. Fatty Acids, Omega-3 32-63 FAT atypical cadherin 1 Mus musculus 109-114 26249019-10 2015 The combined vitamin B12 and omega-3 fatty acid supplementation further enhanced the levels of DHA (P < 0.05) and BDNF (P < 0.05) in the hippocampus and CREB mRNA (P < 0.01) in the cortex as compared with BS group. Fatty Acids, Omega-3 29-47 brain-derived neurotrophic factor Rattus norvegicus 117-121 26249019-10 2015 The combined vitamin B12 and omega-3 fatty acid supplementation further enhanced the levels of DHA (P < 0.05) and BDNF (P < 0.05) in the hippocampus and CREB mRNA (P < 0.01) in the cortex as compared with BS group. Fatty Acids, Omega-3 29-47 cAMP responsive element binding protein 1 Rattus norvegicus 159-163 26005865-1 2015 The major pathway by which the brain obtains essential omega-3 fatty acids from the circulation is through a sodium-dependent lysophosphatidylcholine (LPC) transporter (MFSD2A), expressed in the endothelium of the blood-brain barrier. Fatty Acids, Omega-3 55-74 major facilitator superfamily domain containing 2A Homo sapiens 169-175 26005868-0 2015 Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Fatty Acids, Omega-3 47-65 major facilitator superfamily domain containing 2A Homo sapiens 26-32 25220417-8 2015 Although some anti-inflammatory effects of omega-3 PUFAs were previously shown to be mediated by the G-protein-coupled receptor 120 (GPR120), the FOD reduced Py230 tumor burden in GPR120-deficient mice to a similar degree as observed in wild-type mice, indicating that the effect of FOD to reduce tumor growth does not require GPR120 in the host mouse. Fatty Acids, Omega-3 43-56 free fatty acid receptor 4 Mus musculus 133-139 26085639-6 2015 We report that the omega-3 fatty acid docosahexaenoic acid (DHA), in combination with bexarotene, enhances LXR:RXR target gene expression of Abca1 and ApoE, reduces soluble forms of Abeta, and abrogates release of pro-inflammatory cytokines and mediators both in vitro and in a mouse model of AD. Fatty Acids, Omega-3 19-37 nuclear receptor subfamily 1, group H, member 3 Mus musculus 107-110 26085639-6 2015 We report that the omega-3 fatty acid docosahexaenoic acid (DHA), in combination with bexarotene, enhances LXR:RXR target gene expression of Abca1 and ApoE, reduces soluble forms of Abeta, and abrogates release of pro-inflammatory cytokines and mediators both in vitro and in a mouse model of AD. Fatty Acids, Omega-3 19-37 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 141-146 26085639-6 2015 We report that the omega-3 fatty acid docosahexaenoic acid (DHA), in combination with bexarotene, enhances LXR:RXR target gene expression of Abca1 and ApoE, reduces soluble forms of Abeta, and abrogates release of pro-inflammatory cytokines and mediators both in vitro and in a mouse model of AD. Fatty Acids, Omega-3 19-37 apolipoprotein E Mus musculus 151-155 26062993-4 2015 Analysis of gut microbiota and fecal transfer revealed that elevated tissue omega-3 fatty acids enhance intestinal production and secretion of intestinal alkaline phosphatase (IAP), which induces changes in the gut bacteria composition resulting in decreased lipopolysaccharide production and gut permeability, and ultimately, reduced metabolic endotoxemia and inflammation. Fatty Acids, Omega-3 76-95 alkaline phosphatase 3, intestine, not Mn requiring Mus musculus 143-174 26062993-4 2015 Analysis of gut microbiota and fecal transfer revealed that elevated tissue omega-3 fatty acids enhance intestinal production and secretion of intestinal alkaline phosphatase (IAP), which induces changes in the gut bacteria composition resulting in decreased lipopolysaccharide production and gut permeability, and ultimately, reduced metabolic endotoxemia and inflammation. Fatty Acids, Omega-3 76-95 alkaline phosphatase 3, intestine, not Mn requiring Mus musculus 176-179 26115279-6 2015 Supplementation of n-3 fatty acids reduced (P < 0.01 and P < 0.05) serum concentrations of cortisol and tumor necrosis factor alpha (TNF-alpha), respectively. Fatty Acids, Omega-3 19-34 tumor necrosis factor Sus scrofa 110-137 25932792-0 2015 Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol. Fatty Acids, Omega-3 22-41 apolipoprotein E Homo sapiens 49-64 25889224-4 2015 It remains to be established whether maternal nutrients like vitamin B12 and omega-3 fatty acids influence the levels of angiogenic markers like VEGF and NGF in the brain of the offspring. Fatty Acids, Omega-3 77-96 vascular endothelial growth factor A Homo sapiens 145-149 25889224-5 2015 Therefore the present study examines the effect of maternal vitamin B12 and omega-3 fatty acids on protein and mRNA levels of VEGF, HIF-1 alpha (hypoxia inducible factor alpha) and NGF in the pup brain at birth. Fatty Acids, Omega-3 76-95 vascular endothelial growth factor A Homo sapiens 126-130 25889224-9 2015 Omega-3 fatty acid supplementation to a vitamin B12 deficient group normalized the VEGF mRNA levels, NGF protein levels and HIF-1 alpha protein levels. Fatty Acids, Omega-3 0-18 vascular endothelial growth factor A Homo sapiens 83-87 25889224-9 2015 Omega-3 fatty acid supplementation to a vitamin B12 deficient group normalized the VEGF mRNA levels, NGF protein levels and HIF-1 alpha protein levels. Fatty Acids, Omega-3 0-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 124-135 24973862-0 2015 Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Fatty Acids, Omega-3 11-29 insulin Homo sapiens 49-56 24973862-1 2015 BACKGROUND & AIMS: We are aware of no study that examined the effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes (GDM). Fatty Acids, Omega-3 77-95 insulin Homo sapiens 115-122 24973862-2 2015 This study was designed to assess the effects of omega-3 fatty acid supplementation on insulin concentrations and lipid profiles among pregnant women with GDM. Fatty Acids, Omega-3 49-67 insulin Homo sapiens 87-94 24973862-7 2015 Furthermore, a significant reduction in serum high sensitivity C-reactive protein (hs-CRP) levels was seen after omega-3 fatty acid supplementation compared with placebo (-236.3 +- 1541.9 vs. 898.6 +- 2292.7 ng/mL, P = 0.03). Fatty Acids, Omega-3 113-131 C-reactive protein Homo sapiens 63-81 24973862-9 2015 CONCLUSIONS: Omega-3 fatty acid supplementation in GDM women had beneficial effects on insulin resistance, however, it did not affect plasma glucose, HOMA-B, QUICKI and lipid profiles. Fatty Acids, Omega-3 13-31 insulin Homo sapiens 87-94 25066733-1 2015 BACKGROUND & AIMS: Although the physiological effects of n-3 polyunsaturated fatty acids (n-3PUFA) are generally thought to require several weeks of exposure to allow their incorporation into plasma membranes, intravenous (IV) n-3PUFA attenuate the cardiovascular and neuroendocrine response to stress within 3 h. Whether oral n-3 PUFA exert similar early effects remains unknown. Fatty Acids, Omega-3 61-92 pumilio RNA binding family member 3 Homo sapiens 97-101 25889224-11 2015 Omega-3 fatty acid supplementation to the vitamin B12 supplemented group showed higher (p<0.01) protein and mRNA levels of NGF but the protein and mRNA levels of VEGF were comparable to control. Fatty Acids, Omega-3 0-18 vascular endothelial growth factor A Homo sapiens 165-169 26115279-6 2015 Supplementation of n-3 fatty acids reduced (P < 0.01 and P < 0.05) serum concentrations of cortisol and tumor necrosis factor alpha (TNF-alpha), respectively. Fatty Acids, Omega-3 19-34 tumor necrosis factor Sus scrofa 139-148 26115279-9 2015 The results suggest that n-3 fatty acids independently attenuate production of TNF-alpha and PGE2 in immune system-stimulated growing-finishing pigs. Fatty Acids, Omega-3 25-40 tumor necrosis factor Sus scrofa 79-88 25771388-10 2015 CONCLUSION: Omega-3 fatty acid supplementation did not increase the number of patients with decreased ALT levels and it did not affect liver steatosis on ultrasound, but it improved aspartate aminotransferase and gamma-glutamyl transpeptidase levels in children with NAFLD compared with placebo. Fatty Acids, Omega-3 12-30 inactive glutathione hydrolase 2 Homo sapiens 213-242 25659769-0 2015 Effect of omega-3 fatty acid oxidation products on the cellular and mitochondrial toxicity of BDE 47. Fatty Acids, Omega-3 10-28 homeobox D13 Homo sapiens 94-97 26925376-10 2015 GENERAL SIGNIFICANCE: Combining caloric restriction and n-3 PUFA improves insulin sensitivity, which may be related to a decrease of GIP levels. Fatty Acids, Omega-3 56-64 insulin Homo sapiens 74-81 26925376-10 2015 GENERAL SIGNIFICANCE: Combining caloric restriction and n-3 PUFA improves insulin sensitivity, which may be related to a decrease of GIP levels. Fatty Acids, Omega-3 56-64 gastric inhibitory polypeptide Homo sapiens 133-136 25860692-1 2015 The consumption of omega-3 polyunsaturated fatty acids (n-3 PUFA) is associated with a reduced risk of breast cancer. Fatty Acids, Omega-3 19-54 pumilio RNA binding family member 3 Homo sapiens 60-64 25816805-2 2015 n-3 polyunsaturated fatty acids (PUFA) from seafood have several beneficial effects in patients with endstage renal disease (ESRD) and the aim of the present study was to assess the effect of n-3 PUFA supplementation on plasma adiponectin levels in ESRD patients. Fatty Acids, Omega-3 0-31 adiponectin, C1Q and collagen domain containing Homo sapiens 227-238 25816805-2 2015 n-3 polyunsaturated fatty acids (PUFA) from seafood have several beneficial effects in patients with endstage renal disease (ESRD) and the aim of the present study was to assess the effect of n-3 PUFA supplementation on plasma adiponectin levels in ESRD patients. Fatty Acids, Omega-3 192-200 adiponectin, C1Q and collagen domain containing Homo sapiens 227-238 26073395-0 2015 Dose-response effects of marine omega-3 fatty acids on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and Lp-PLA2 in individuals with moderate hypertriglyceridemia. Fatty Acids, Omega-3 32-51 apolipoprotein E Homo sapiens 55-70 25782746-8 2015 Choline and omega-3 fatty acids have similar biological functions-affecting cell membranes, growth factor levels, and epigenetically altering gene transcription. Fatty Acids, Omega-3 12-31 myotrophin Rattus norvegicus 92-105 25641959-0 2015 Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARgamma-dependent and PPARgamma-independent actions. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor gamma Mus musculus 116-125 25641959-0 2015 Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARgamma-dependent and PPARgamma-independent actions. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor gamma Mus musculus 140-149 25641959-1 2015 SCOPE: We tested herein the hypothesis that peroxisome proliferator activated receptor gamma (PPARgamma) is a major mediator of omega-3 (n-3) protective actions against high-fat diet (HFD) induced obesity, glucose intolerance, and adipose tissue inflammation. Fatty Acids, Omega-3 128-135 peroxisome proliferator activated receptor gamma Mus musculus 44-92 25641959-1 2015 SCOPE: We tested herein the hypothesis that peroxisome proliferator activated receptor gamma (PPARgamma) is a major mediator of omega-3 (n-3) protective actions against high-fat diet (HFD) induced obesity, glucose intolerance, and adipose tissue inflammation. Fatty Acids, Omega-3 128-135 peroxisome proliferator activated receptor gamma Mus musculus 94-103 25860776-0 2015 Effect of Different Omega-6/Omega-3 Polyunsaturated Fatty Acid Ratios on the Formation of Monohydroxylated Fatty Acids in THP-1 Derived Macrophages. Fatty Acids, Omega-3 28-62 GLI family zinc finger 2 Homo sapiens 122-127 25860776-1 2015 Omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFA) can modulate inflammatory processes. Fatty Acids, Omega-3 12-47 pumilio RNA binding family member 3 Homo sapiens 61-65 25860776-3 2015 The aim of this study was to analyze the effect of modulating the n-6/n-3 PUFA ratio on the formation of monohydroxylated fatty acid (HO-FAs) derived from the n-6 PUFA arachidonic acid (AA) and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in THP-1 macrophages by means of LC-MS. Lipid metabolites were measured in THP-1 macrophage cell pellets. Fatty Acids, Omega-3 198-207 pumilio RNA binding family member 3 Homo sapiens 74-78 25860776-3 2015 The aim of this study was to analyze the effect of modulating the n-6/n-3 PUFA ratio on the formation of monohydroxylated fatty acid (HO-FAs) derived from the n-6 PUFA arachidonic acid (AA) and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in THP-1 macrophages by means of LC-MS. Lipid metabolites were measured in THP-1 macrophage cell pellets. Fatty Acids, Omega-3 198-207 pumilio RNA binding family member 3 Homo sapiens 163-167 25849351-0 2015 Dietary n-3 polyunsaturated fatty acid intakes modify the effect of genetic variation in fatty acid desaturase 1 on coronary artery disease. Fatty Acids, Omega-3 8-38 fatty acid desaturase 1 Homo sapiens 89-112 30155437-10 2015 Longer chain omega-3 fatty acids may play a role in regulating adiponectin concentrations in dogs. Fatty Acids, Omega-3 13-32 adiponectin, C1Q and collagen domain containing Canis lupus familiaris 63-74 30155437-12 2015 EPA and DPA may reduce the overall inflammatory state in dogs as these omega-3 fatty acids reflect increased adiponectin (increased EPA and decreased DHA) and decreased leptin (decreased DHA and increased DPA). Fatty Acids, Omega-3 71-90 adiponectin, C1Q and collagen domain containing Canis lupus familiaris 109-120 25852263-8 2015 Currently, insulin sensitizers (thiazolidinediones) and antioxidants (vitamin E) seem to be the most promising therapeutic agents for NAFLD/NASH, and lipid-lowering drugs, pentoxifylline, angiotensin receptor blockers, and n-3 polyunsaturated fatty acids also have promise. Fatty Acids, Omega-3 223-254 insulin Homo sapiens 11-18 25631736-4 2015 Our results showed that n-3 PUFAs docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) remarkably attenuated the adhesion of THP-1 cells to HAECs, probably through inhibiting the expression of VCAM-1 and ICAM-1. Fatty Acids, Omega-3 24-33 GLI family zinc finger 2 Homo sapiens 131-136 25845931-0 2015 Endogenously generated omega-3 fatty acids attenuate vascular inflammation and neointimal hyperplasia by interaction with free fatty acid receptor 4 in mice. Fatty Acids, Omega-3 23-42 free fatty acid receptor 4 Mus musculus 122-148 25845931-1 2015 BACKGROUND: Omega-3 polyunsaturated fatty acids (omega3 PUFAs) suppress inflammation through activation of free fatty acid receptor 4 (FFAR4), but this pathway has not been explored in the context of cardiovascular disease. Fatty Acids, Omega-3 12-47 free fatty acid receptor 4 Mus musculus 107-133 25845931-1 2015 BACKGROUND: Omega-3 polyunsaturated fatty acids (omega3 PUFAs) suppress inflammation through activation of free fatty acid receptor 4 (FFAR4), but this pathway has not been explored in the context of cardiovascular disease. Fatty Acids, Omega-3 12-47 free fatty acid receptor 4 Mus musculus 135-140 25512019-11 2015 CONCLUSION: Dietary supplementation with n-3 PUFAs may have protective anti-inflammatory effects mediated through modulation of MMPs and TIMPs. Fatty Acids, Omega-3 41-50 matrix metallopeptidase 2 Mus musculus 128-132 25631736-4 2015 Our results showed that n-3 PUFAs docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) remarkably attenuated the adhesion of THP-1 cells to HAECs, probably through inhibiting the expression of VCAM-1 and ICAM-1. Fatty Acids, Omega-3 24-33 vascular cell adhesion molecule 1 Homo sapiens 199-205 25631736-4 2015 Our results showed that n-3 PUFAs docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) remarkably attenuated the adhesion of THP-1 cells to HAECs, probably through inhibiting the expression of VCAM-1 and ICAM-1. Fatty Acids, Omega-3 24-33 intercellular adhesion molecule 1 Homo sapiens 210-216 25687496-1 2015 This paper presents a systematic review of human studies investigating the effect of altering dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) alpha-linolenic acid (ALA) and omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) intakes on n-3 long-chain polyunsaturated fatty acid (LCPUFA) status in adult humans. Fatty Acids, Omega-3 102-136 pumilio RNA binding family member 3 Homo sapiens 142-146 25701338-0 2015 omega-3 fatty acid differentially modulated serum levels of IGF1 and IGFBP3 in men with CVD: a randomized, double-blind placebo-controlled study. Fatty Acids, Omega-3 0-18 insulin like growth factor 1 Homo sapiens 60-64 25394495-3 2015 In this study, we focused on the regulatory effect of docosahexanoic acid (DHA), one type of omega-3 fatty acid, exerted on the LDL receptor (LDLR), a determinant regulator of the LDL-C metabolism, and explored the potential mechanism. Fatty Acids, Omega-3 93-111 low density lipoprotein receptor Homo sapiens 128-140 25394495-3 2015 In this study, we focused on the regulatory effect of docosahexanoic acid (DHA), one type of omega-3 fatty acid, exerted on the LDL receptor (LDLR), a determinant regulator of the LDL-C metabolism, and explored the potential mechanism. Fatty Acids, Omega-3 93-111 low density lipoprotein receptor Homo sapiens 142-146 25701338-0 2015 omega-3 fatty acid differentially modulated serum levels of IGF1 and IGFBP3 in men with CVD: a randomized, double-blind placebo-controlled study. Fatty Acids, Omega-3 0-18 insulin like growth factor binding protein 3 Homo sapiens 69-75 25701338-9 2015 Compared with placebo, omega-3 supplementation increased serum IGF1 levels (P = 0.01), and decreased serum level of IGFBP3 (P = 0.02). Fatty Acids, Omega-3 23-30 insulin like growth factor 1 Homo sapiens 63-67 25701338-9 2015 Compared with placebo, omega-3 supplementation increased serum IGF1 levels (P = 0.01), and decreased serum level of IGFBP3 (P = 0.02). Fatty Acids, Omega-3 23-30 insulin like growth factor binding protein 3 Homo sapiens 116-122 25701338-11 2015 CONCLUSIONS: omega-3 supplementation in patients with CVD increases serum IGF1 levels and decreases serum IGFBP3. Fatty Acids, Omega-3 13-20 insulin like growth factor 1 Homo sapiens 74-78 25701338-11 2015 CONCLUSIONS: omega-3 supplementation in patients with CVD increases serum IGF1 levels and decreases serum IGFBP3. Fatty Acids, Omega-3 13-20 insulin like growth factor binding protein 3 Homo sapiens 106-112 25690094-0 2015 Fish oil N-3 fatty acids increase adiponectin and decrease leptin levels in patients with systemic lupus erythematosus. Fatty Acids, Omega-3 9-24 adiponectin, C1Q and collagen domain containing Homo sapiens 34-45 25586183-0 2015 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy omega-3 fatty acids. Fatty Acids, Omega-3 105-124 carbonyl reductase 1 Homo sapiens 0-37 25586183-9 2015 These data reveal that 15PGDH-derived DHA metabolites are biologically active and can contribute to the salutary signaling actions of Omega-3 fatty acids. Fatty Acids, Omega-3 134-153 carbonyl reductase 1 Homo sapiens 23-29 25889505-10 2015 These studies suggest that omega-3 fatty acids have different potencies to preclude lipid accumulation in the offspring partially by affecting pathways associated to SCD1 modulation. Fatty Acids, Omega-3 27-46 stearoyl-Coenzyme A desaturase 1 Mus musculus 166-170 25690094-0 2015 Fish oil N-3 fatty acids increase adiponectin and decrease leptin levels in patients with systemic lupus erythematosus. Fatty Acids, Omega-3 9-24 leptin Homo sapiens 59-65 25351720-0 2015 N-3 polyunsaturated fatty acids inhibit IFN-gamma-induced IL-18 binding protein production by prostate cancer cells. Fatty Acids, Omega-3 0-31 interferon gamma Homo sapiens 40-49 25699037-0 2015 Threonine 286 of fatty acid desaturase 7 is essential for omega-3 fatty acid desaturation in the green microalga Chlamydomonas reinhardtii. Fatty Acids, Omega-3 58-76 uncharacterized protein Chlamydomonas reinhardtii 17-40 25699037-2 2015 Here, we describe a Thr residue located in the fourth transmembrane domain of fatty acid desaturase 7 (FAD7) that is essential for the biosynthesis of omega-3 fatty acids in C. reinhardtii. Fatty Acids, Omega-3 151-170 uncharacterized protein Chlamydomonas reinhardtii 78-101 25699037-2 2015 Here, we describe a Thr residue located in the fourth transmembrane domain of fatty acid desaturase 7 (FAD7) that is essential for the biosynthesis of omega-3 fatty acids in C. reinhardtii. Fatty Acids, Omega-3 151-170 uncharacterized protein Chlamydomonas reinhardtii 103-107 25351720-0 2015 N-3 polyunsaturated fatty acids inhibit IFN-gamma-induced IL-18 binding protein production by prostate cancer cells. Fatty Acids, Omega-3 0-31 interleukin 18 binding protein Homo sapiens 58-79 25551801-5 2015 n-3 polyunsaturated fatty acids (PUFAs) intake reduces the production of apoB-48-containing lipoproteins as well as of VLDL apoB-100 and increases their conversion into smaller lipoproteins. Fatty Acids, Omega-3 0-31 apolipoprotein B Homo sapiens 124-132 24862919-0 2015 Does omega-3 fatty acids supplementation affect circulating leptin levels? Fatty Acids, Omega-3 5-24 leptin Homo sapiens 60-66 24862919-3 2015 OBJECTIVE: Our objective was to conduct a systematic review and meta-analysis on randomized controlled trials (RCTs) assessed the effects of omega-3 supplementation on serum leptin concentration and to find the possible sources of heterogeneity in their results. Fatty Acids, Omega-3 141-148 leptin Homo sapiens 174-180 24862919-5 2015 RCTs conducted among human adults, examined the effect of omega-3 fatty acid supplements on serum leptin concentrations as an outcome variable were included. Fatty Acids, Omega-3 58-76 leptin Homo sapiens 98-104 24862919-9 2015 Our analysis showed that omega-3 supplementation significantly reduces leptin levels (mean difference (MD) = -1 71 ng/ml 95% confidence interval (CI): -3 17 to -0 24, P = 0 022). Fatty Acids, Omega-3 25-32 leptin Homo sapiens 71-77 24862919-10 2015 Subgroup analysis based on BMI status showed that the omega-3 supplementation reduces leptin when used for nonobese subjects (MD = -3 60 ng/ml; 95% CI -6 23 to -0 90; P = 0 011); however, this was not true for obese participants (MD = -0 86 ng/ml; 95% CI: -2 63 to -0 90; P = 0 296). Fatty Acids, Omega-3 54-61 leptin Homo sapiens 86-92 24862919-13 2015 CONCLUSIONS: Omega-3 supplementation might moderately decrease circulatory leptin levels only among nonobese adults. Fatty Acids, Omega-3 13-20 leptin Homo sapiens 75-81 25999995-0 2015 Influence of omega-3 fatty acid eicosapentaenoic acid on IGF-1 and COX-2 gene expression in granulosa cells of PCOS women. Fatty Acids, Omega-3 13-31 prostaglandin-endoperoxide synthase 2 Homo sapiens 67-72 25207475-7 2015 RESULTS: Significantly decreased docosapentaenoic (C22:5n-3), docosahexaenoic (C22:6n-3), n-3 polyunsaturated fatty acids (n-3 PUFA), and n-3 LCPUFA values were found in CDDM group compared with controls and patients with CD. Fatty Acids, Omega-3 90-121 pumilio RNA binding family member 3 Homo sapiens 127-131 25504868-1 2015 The aim of this study was to determine whether supplementation with fish oil-derived n-3 polyunsaturated fatty acids (n-3 PUFA) during pregnancy modifies placental PUFA composition, the accumulation of specialised pro-resolving lipid mediators (SPMs, specifically resolvins (Rv), protectins (PD) and upstream precursors) and inflammatory gene expression. Fatty Acids, Omega-3 85-116 pumilio RNA binding family member 3 Homo sapiens 122-126 25204316-10 2015 Supplementation of omega-3 PUFAs effectively decreased the LPS-induced PBMC expression of RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) and MCP-1 (Monocyte Chemotactic Protein-1; unadjusted P = 0.04 and 0.06; adjusted for demographics P = 0.02 and 0.05, respectively). Fatty Acids, Omega-3 19-32 C-C motif chemokine ligand 5 Homo sapiens 90-96 25204316-10 2015 Supplementation of omega-3 PUFAs effectively decreased the LPS-induced PBMC expression of RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) and MCP-1 (Monocyte Chemotactic Protein-1; unadjusted P = 0.04 and 0.06; adjusted for demographics P = 0.02 and 0.05, respectively). Fatty Acids, Omega-3 19-32 C-C motif chemokine ligand 2 Homo sapiens 167-172 25204316-10 2015 Supplementation of omega-3 PUFAs effectively decreased the LPS-induced PBMC expression of RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) and MCP-1 (Monocyte Chemotactic Protein-1; unadjusted P = 0.04 and 0.06; adjusted for demographics P = 0.02 and 0.05, respectively). Fatty Acids, Omega-3 19-32 C-C motif chemokine ligand 2 Homo sapiens 174-204 25204316-12 2015 CONCLUSIONS: The results of this pilot study suggest that supplementation of omega-3 PUFAs is beneficial in decreasing the levels of endothelial chemokines, RANTES and MCP-1. Fatty Acids, Omega-3 77-90 C-C motif chemokine ligand 5 Homo sapiens 157-163 25204316-12 2015 CONCLUSIONS: The results of this pilot study suggest that supplementation of omega-3 PUFAs is beneficial in decreasing the levels of endothelial chemokines, RANTES and MCP-1. Fatty Acids, Omega-3 77-90 C-C motif chemokine ligand 2 Homo sapiens 168-173 25449400-7 2015 N-3 polyunsaturated fatty acids (PUFAs) or sertraline administration reversed the changes in behavioral test and induced the expression of tPA in certain brain areas, but failed to restore the CUMS-induced PAI-1 expression. Fatty Acids, Omega-3 0-31 plasminogen activator, tissue type Rattus norvegicus 139-142 25504868-1 2015 The aim of this study was to determine whether supplementation with fish oil-derived n-3 polyunsaturated fatty acids (n-3 PUFA) during pregnancy modifies placental PUFA composition, the accumulation of specialised pro-resolving lipid mediators (SPMs, specifically resolvins (Rv), protectins (PD) and upstream precursors) and inflammatory gene expression. Fatty Acids, Omega-3 85-116 pumilio RNA binding family member 3 Homo sapiens 164-168 25880054-7 2015 RESULTS: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. Fatty Acids, Omega-3 28-47 fatty acid binding protein 4 Homo sapiens 120-125 25880054-0 2015 Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD. Fatty Acids, Omega-3 29-48 adiponectin, C1Q and collagen domain containing Homo sapiens 94-105 25498892-0 2015 Omega-3 fatty acids prevent the ketamine-induced increase in acetylcholinesterase activity in an animal model of schizophrenia. Fatty Acids, Omega-3 0-19 acetylcholinesterase Rattus norvegicus 61-81 25498892-3 2015 Therefore, we evaluated the preventive effects of omega-3 fatty acids on AChE activity in the prefrontal cortex, hippocampus and striatum in an animal model of schizophrenia. Fatty Acids, Omega-3 50-69 acetylcholinesterase Rattus norvegicus 73-77 25498892-10 2015 Together, these results indicate that omega-3 fatty acid supplementation effectively reduced AChE activity in an animal model of schizophrenia in all studied structures. Fatty Acids, Omega-3 38-56 acetylcholinesterase Rattus norvegicus 93-97 25880054-3 2015 The current trial study assessed the effects of omega-3 fatty acids with or without vitamin E on adiponectin gene expression in peripheral blood mononuclear cells and serum adiponectin and adipocyte fatty acid-binding protein (A-FABP; also called ap2 and FABP4) levels in patients with coronary artery disease (CAD). Fatty Acids, Omega-3 48-67 adiponectin, C1Q and collagen domain containing Homo sapiens 97-108 25880054-7 2015 RESULTS: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. Fatty Acids, Omega-3 28-47 adiponectin, C1Q and collagen domain containing Homo sapiens 104-115 25880054-7 2015 RESULTS: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. Fatty Acids, Omega-3 28-47 adiponectin, C1Q and collagen domain containing Homo sapiens 141-152 25880054-7 2015 RESULTS: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. Fatty Acids, Omega-3 28-47 fatty acid binding protein 4 Homo sapiens 153-158 25880054-10 2015 CONCLUSION: Omega-3 fatty acids with or without vitamin E improve adiponectin levels in patients, without any significant changes in adiponectin gene expression. Fatty Acids, Omega-3 12-31 adiponectin, C1Q and collagen domain containing Homo sapiens 66-77 26301252-1 2015 Omega-3 polyunsaturated fatty acids (n-3 PUFA) consumption is associated with reduced cardiovascular disease risk. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 25665478-0 2015 Effect of vitamins A, E, C and omega-3 fatty acids supplementation on the level of catalase and superoxide dismutase activities in streptozotocin-induced diabetic rats. Fatty Acids, Omega-3 31-50 catalase Rattus norvegicus 83-91 26339623-2 2015 N-3 Polyunsaturated fatty acids (n-3 PUFA), known as important modulators participating in inflammatory process, turn out to be an effective mitigating strategy dealing with local and systemic inflammation observed in obesity. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 37-41 25665478-1 2015 BACKGROUND: Since free radicals and antioxidant enzymes may play an important role in the development of diabetes, the present study was designed to assess the effect of supplementation with vitamins A, E and C and omega-3 fatty acids on catalase and superoxide dismutase activity in streptozotocin (STZ)-induced diabetic rats. Fatty Acids, Omega-3 215-234 catalase Rattus norvegicus 238-246 25665478-7 2015 CONCLUSION: Supplementation with vitamins A, E and C and omega-3 fatty acids was found to increase heart CAT activity in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes (Tab. Fatty Acids, Omega-3 57-76 catalase Rattus norvegicus 105-108 26230883-1 2015 GPR120 receptor functions as a receptor for omega-3 fatty acid, involving regulating the secretion of gastrointestinal peptide hormone, adipogenesis, adipogenic differentiation and anti-inflammatory process and the like in the aspect of biological functions. Fatty Acids, Omega-3 44-62 free fatty acid receptor 4 Homo sapiens 0-6 25975008-1 2015 BACKGROUND: To investigate the effect of different ratios of n-6/n-3 polyunsaturated fatty acids (PUFAs) on the expression of lipid metabolic genes and estrogen receptor (ER). Fatty Acids, Omega-3 65-96 estrogen receptor 1 Homo sapiens 152-169 25975008-1 2015 BACKGROUND: To investigate the effect of different ratios of n-6/n-3 polyunsaturated fatty acids (PUFAs) on the expression of lipid metabolic genes and estrogen receptor (ER). Fatty Acids, Omega-3 65-96 estrogen receptor 1 Homo sapiens 171-173 25176010-1 2015 The study aimed to evaluate the effects of a 3-week n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on serum nitric oxide (NO), asymmetric dimethyloarginine (ADMA), ultrasound indices of endothelial function and maximal oxygen uptake (VO2 max) of elite cyclists. Fatty Acids, Omega-3 52-83 pumilio RNA binding family member 3 Homo sapiens 89-93 26447526-0 2015 Modulation of cardiac connexin-43 by omega-3 fatty acid ethyl-ester supplementation demonstrated in spontaneously diabetic rats. Fatty Acids, Omega-3 37-55 gap junction protein, alpha 1 Rattus norvegicus 22-33 25557903-0 2015 Omega-3 fatty acid profile of eggs from laying hens fed diets supplemented with chia, fish oil, and flaxseed. Fatty Acids, Omega-3 0-18 acidic mammalian chitinase Gallus gallus 80-84 25557903-1 2015 The aim of this study was to investigate the effect of diets supplemented with fish oil, flaxseed, and chia seed on the omega-3 fatty acid composition and sensory properties of hens" eggs. Fatty Acids, Omega-3 120-138 acidic mammalian chitinase Gallus gallus 103-107 25557903-4 2015 Inclusion of chia at 300 g/kg into the diet produced eggs with the highest concentration of omega-3 fatty acid. Fatty Acids, Omega-3 92-110 acidic mammalian chitinase Gallus gallus 13-17 25557903-8 2015 Inclusion of chia into the hens" diet significantly increased the concentration of yolk omega-3 fatty acid without significant change in sensory properties. Fatty Acids, Omega-3 88-106 acidic mammalian chitinase Gallus gallus 13-17 26087900-0 2015 Modulation of the Association between the PEPD Variant and the Risk of Type 2 Diabetes by n-3 Fatty Acids in Chinese Hans. Fatty Acids, Omega-3 90-105 peptidase D Homo sapiens 42-46 26087900-7 2015 RESULTS: Among the 9 SNPs, only rs3786897 at PEPD (peptidase D) showed a significant interaction with n-3 fatty acids (p(interaction) after Bonferroni correction = 0.027). Fatty Acids, Omega-3 102-117 peptidase D Homo sapiens 45-49 26087900-7 2015 RESULTS: Among the 9 SNPs, only rs3786897 at PEPD (peptidase D) showed a significant interaction with n-3 fatty acids (p(interaction) after Bonferroni correction = 0.027). Fatty Acids, Omega-3 102-117 peptidase D Homo sapiens 51-62 26087900-9 2015 CONCLUSIONS: The association between the PEPD genetic variant and the risk of T2D was modulated by n-3 fatty acids. Fatty Acids, Omega-3 99-114 peptidase D Homo sapiens 41-45 26087900-10 2015 Higher n-3 fatty acids may abolish the adverse effect of the risk allele at PEPD for T2D. Fatty Acids, Omega-3 7-22 peptidase D Homo sapiens 76-80 26401996-0 2015 Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-beta Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. Fatty Acids, Omega-3 41-60 amyloid beta precursor protein Homo sapiens 69-81 26401996-6 2015 In a recent study of AD and MCI patients, nutritional supplementation by omega-3 fatty acids individually increased resolvin D1, improved Abeta phagocytosis, and regulated inflammatory genes toward a physiological state, but only in MCI patients. Fatty Acids, Omega-3 73-92 amyloid beta precursor protein Homo sapiens 138-143 25733777-4 2015 Mediterranean-like diet and omega-3 fatty acids (n3-PUFA) have documented cardioprotective and anti-inflammatory effects. Fatty Acids, Omega-3 28-47 pumilio RNA binding family member 3 Homo sapiens 52-56 25283985-2 2015 Here we report that early exposure to dietary omega-3 fatty acids orchestrates key interactions between metabolic signals and Bdnf methylation creating a reservoir of neuroplasticity that can protect the brain against the deleterious effects of switching to a Western diet (WD). Fatty Acids, Omega-3 46-65 brain-derived neurotrophic factor Rattus norvegicus 126-130 25425246-1 2015 This study was aimed to systematically evaluate results of trials examining the effects of omega-3 polyunsaturated fatty acid (n-3 PUFA) consumption on body weight, lean body mass, resting energy expenditure, and overall survival in pancreatic cancer patients. Fatty Acids, Omega-3 91-125 pumilio RNA binding family member 3 Homo sapiens 131-135 26447526-7 2015 Myocardial Cx43 mRNA and protein levels were higher in diabetic versus non-diabetic rats and were further enhanced by omega-3. Fatty Acids, Omega-3 118-125 gap junction protein, alpha 1 Rattus norvegicus 11-15 26447526-8 2015 The ratio of phosphorylated (functional) to non-phosphorylated Cx43 was lower in diabetic compared to non-diabetic rats but was increased by omega-3, in part due to up-regulation of PKC-epsilon. Fatty Acids, Omega-3 141-148 gap junction protein, alpha 1 Rattus norvegicus 63-67 26179891-0 2015 Effects of diet and/or n-3 fatty acid supplementation on components of the interleukin-6 trans-signalling system in elderly men. Fatty Acids, Omega-3 23-37 interleukin 6 Homo sapiens 75-88 26179891-1 2015 BACKGROUND: It has previously been shown that both very long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and a Mediterranean-like diet (Md), are able to reduce the risk of cardiovascular (CV) mortality and morbidity. Fatty Acids, Omega-3 67-102 pumilio RNA binding family member 3 Homo sapiens 108-112 25580420-0 2014 Expression of ezrin in vagina cells of postmenopausal rats after dietary administration of omega-3 Fatty Acid formula. Fatty Acids, Omega-3 91-109 ezrin Rattus norvegicus 14-19 24996368-1 2014 Fish is often promoted as a healthy part of the human diet due its high content of long chain n-3 polyunsaturated fatty acids (LC-PUFA). Fatty Acids, Omega-3 94-125 pumilio RNA binding family member 3 Homo sapiens 130-134 25670984-7 2014 The response of unstimulated and activated moDC to n-3 fatty acid treatment was tested by measuring the cell surface expression of CD1a used as a phenotypic and CD83 as an activation marker of inflammatory moDC differentiation and activation by using flow cytometry. Fatty Acids, Omega-3 51-65 CD1a molecule Homo sapiens 131-135 25670984-7 2014 The response of unstimulated and activated moDC to n-3 fatty acid treatment was tested by measuring the cell surface expression of CD1a used as a phenotypic and CD83 as an activation marker of inflammatory moDC differentiation and activation by using flow cytometry. Fatty Acids, Omega-3 51-65 CD83 molecule Homo sapiens 161-165 25670984-9 2014 We found that RAMEA-complexed n-3 fatty acids reduced the expression of CD1a protein in both LPS and Poly(I:C) stimulated moDC significantly, but most efficiently by eicosapentaenic acid, while no significant change in the expression of CD83 protein was observed. Fatty Acids, Omega-3 30-45 CD1a molecule Homo sapiens 72-76 25670984-9 2014 We found that RAMEA-complexed n-3 fatty acids reduced the expression of CD1a protein in both LPS and Poly(I:C) stimulated moDC significantly, but most efficiently by eicosapentaenic acid, while no significant change in the expression of CD83 protein was observed. Fatty Acids, Omega-3 30-45 CD83 molecule Homo sapiens 237-241 25670984-10 2014 The production of IL-6 by LPS-activated moDC was also reduced significantly when eicosapentaenic acid was added as a RAMEA complex as compared to its DMSO-solubilized form or to the other two n-3 fatty acids either complexed or not. Fatty Acids, Omega-3 192-207 interleukin 6 Homo sapiens 18-22 25670984-11 2014 Based on these results n-3 fatty acids solubilized by RAMEA provide with a new tool for optimizing the anti-inflammatory effects of n-3 fatty acids exerted on human moDC and mediated through the GP120 receptor without interfering with the cell membrane structure. Fatty Acids, Omega-3 23-38 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 195-200 25670984-11 2014 Based on these results n-3 fatty acids solubilized by RAMEA provide with a new tool for optimizing the anti-inflammatory effects of n-3 fatty acids exerted on human moDC and mediated through the GP120 receptor without interfering with the cell membrane structure. Fatty Acids, Omega-3 132-147 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 195-200 25496415-1 2014 BACKGROUND: There is a metabolic pathway by which mammals can convert the omega-3 (n-3) essential fatty acid alpha-linolenic acid (ALA) into longer-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Fatty Acids, Omega-3 154-185 pumilio RNA binding family member 3 Homo sapiens 194-198 25407516-0 2014 N-3 polyunsaturated fatty acids decrease levels of doxorubicin-induced reactive oxygen species in cardiomyocytes -- involvement of uncoupling protein UCP2. Fatty Acids, Omega-3 0-31 uncoupling protein 2 Homo sapiens 150-154 25301204-1 2014 Evidences suggest that omega-3 fatty acid (n-3 PUFA) metabolism is imbalanced in apolipoprotein E epsilon 4 isoform carriers (APOE4). Fatty Acids, Omega-3 23-41 apolipoprotein E Mus musculus 81-97 25301204-1 2014 Evidences suggest that omega-3 fatty acid (n-3 PUFA) metabolism is imbalanced in apolipoprotein E epsilon 4 isoform carriers (APOE4). Fatty Acids, Omega-3 43-51 apolipoprotein E Mus musculus 81-97 25316121-0 2014 Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 73-108 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 8-14 25316121-2 2014 Cytochrome P450 1A1 efficiently metabolizes n-3 PUFAs to potent vasodilators. Fatty Acids, Omega-3 44-53 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-19 25316121-3 2014 Thus, we hypothesized that dietary n-3 PUFAs increase nitric oxide (NO)-dependent blood pressure regulation and vasodilation in a CYP1A1-dependent manner. Fatty Acids, Omega-3 35-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 130-136 25089785-1 2014 The optimization of a gelled oil-in-water emulsion was performed for use as fat replacer in the formulation of omega-3 PUFA-enriched cooked meat products. Fatty Acids, Omega-3 111-118 pumilio RNA binding family member 3 Homo sapiens 119-123 25063539-13 2014 CONCLUSION: A higher intake of fish and dietary n-3 fatty acids (EPA-DHA) is related to lower circulating FGF23 levels in renal transplant recipients. Fatty Acids, Omega-3 48-63 fibroblast growth factor 23 Homo sapiens 106-111 25287609-5 2014 In addition, the mitigating effects of n-3 polyunsaturated fatty acids (n-3 PUFA) on the inflammation-associated synthesis of prostaglandins and their role as substrates for pro-resolving lipid mediators may also include effects in the H-P axis. Fatty Acids, Omega-3 39-70 pumilio RNA binding family member 3 Homo sapiens 76-80 25089351-10 2014 RESULTS: Patients receiving omega-3s (group 1) had significantly lower levels of vitreal VEGF-A (141.11 +- 61.89 pg/mL) when compared with group 2 (626.09 +- 279.27 pg/mL; P = .036) and group 3 (735.48 +- 216.43 pg/mL; P = .013), but similar levels to group 4 (235.81 +- 33.99 pg/mL; P = .215). Fatty Acids, Omega-3 28-36 vascular endothelial growth factor A Homo sapiens 89-95 25386693-1 2014 Chilean diets are characterized by a low supply of n-3 polyunsaturated fatty acids (n-3 PUFA), which are critical nutrients during pregnancy and lactation, because of their role in brain and visual development. Fatty Acids, Omega-3 51-82 pumilio RNA binding family member 3 Homo sapiens 88-92 25372486-0 2014 Modulation of K(Ca)3.1 channels by eicosanoids, omega-3 fatty acids, and molecular determinants. Fatty Acids, Omega-3 48-67 potassium calcium-activated channel subfamily N member 4 Homo sapiens 14-22 25089351-0 2014 Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration. Fatty Acids, Omega-3 0-7 vascular endothelial growth factor A Homo sapiens 103-137 25089351-1 2014 PURPOSE: To determine the influence of omega-3 supplementation on vitreous vascular endothelial growth factor A (VEGF-A) levels in patients with exudative age-related macular degeneration (wet AMD) receiving intravitreal anti-VEGF treatment. Fatty Acids, Omega-3 39-46 vascular endothelial growth factor A Homo sapiens 75-111 25089351-12 2014 CONCLUSIONS: This study demonstrated that omega-3 supplementation combined with anti-VEGF treatment is associated with decreased vitreal VEGF-A levels in wet AMD patients. Fatty Acids, Omega-3 42-49 vascular endothelial growth factor A Homo sapiens 137-143 25089351-1 2014 PURPOSE: To determine the influence of omega-3 supplementation on vitreous vascular endothelial growth factor A (VEGF-A) levels in patients with exudative age-related macular degeneration (wet AMD) receiving intravitreal anti-VEGF treatment. Fatty Acids, Omega-3 39-46 vascular endothelial growth factor A Homo sapiens 113-119 25089351-1 2014 PURPOSE: To determine the influence of omega-3 supplementation on vitreous vascular endothelial growth factor A (VEGF-A) levels in patients with exudative age-related macular degeneration (wet AMD) receiving intravitreal anti-VEGF treatment. Fatty Acids, Omega-3 39-46 vascular endothelial growth factor A Homo sapiens 113-117 25088402-11 2014 These beneficial effects are absent in mice with polymorphisms in the Ppargamma gene (6T), supporting the tenet that the actions of n-3 fatty acids on bone microstructure are likely to be genotype dependent. Fatty Acids, Omega-3 132-147 peroxisome proliferator activated receptor gamma Mus musculus 70-79 24953262-4 2014 Recent studies suggest that the levels of BDNF and NGF are regulated by docosahexaenoic acid (DHA) which is an important omega-3 fatty acid and is a structural component of the plasma membrane. Fatty Acids, Omega-3 121-139 brain derived neurotrophic factor Homo sapiens 42-46 25080404-0 2014 Dietary supplementation of omega-3 fatty acids rescues fragile X phenotypes in Fmr1-Ko mice. Fatty Acids, Omega-3 27-46 fragile X messenger ribonucleoprotein 1 Mus musculus 79-83 25147070-1 2014 BACKGROUND: Experimental studies demonstrate that higher intake of omega-3 fatty acids (n-3 FA) improves insulin sensitivity, however, we reported that n-3 FA 2g therapy, most commonly used dosage did not significantly improve insulin sensitivity despite reducing triglycerides by 21% in patients. Fatty Acids, Omega-3 67-86 insulin Homo sapiens 105-112 24972532-5 2014 PNPLA3 (I148M) minor allele carriers had an increased n-3 polyunsaturated fatty acid (PUFA) alpha-linolenic acid content and reductions in several n-6 PUFAs in the liver TAG fraction. Fatty Acids, Omega-3 54-84 patatin like phospholipase domain containing 3 Homo sapiens 0-6 26461405-14 2014 Omega-3 fatty acids also stimulate anti-inflammatory cytokines (IL-10) or inhibit the cyclooxygenase, platelet aggregation and formation of eicosanoids. Fatty Acids, Omega-3 0-19 interleukin 10 Homo sapiens 64-69 25445629-1 2014 Various studies have demonstrated the impact of omega-3 fatty acids on the concentration of C reactive protein (CRP), pro-inflammatory eicosanoids, cytokines, chemokines and other inflammatory mediators. Fatty Acids, Omega-3 48-67 C-reactive protein Homo sapiens 92-110 25445629-1 2014 Various studies have demonstrated the impact of omega-3 fatty acids on the concentration of C reactive protein (CRP), pro-inflammatory eicosanoids, cytokines, chemokines and other inflammatory mediators. Fatty Acids, Omega-3 48-67 C-reactive protein Homo sapiens 112-115 24602409-4 2014 In addition, lower erythrocyte levels of omega-3 polyunsaturated fatty acids have been associated with an increased risk of IFN-induced depression. Fatty Acids, Omega-3 41-76 interferon alpha 1 Homo sapiens 124-127 24953262-4 2014 Recent studies suggest that the levels of BDNF and NGF are regulated by docosahexaenoic acid (DHA) which is an important omega-3 fatty acid and is a structural component of the plasma membrane. Fatty Acids, Omega-3 121-139 nerve growth factor Homo sapiens 51-54 25227179-1 2014 BACKGROUND: We have previously demonstrated that carrying the apolipoprotein (apo) E epsilon 4 (E4+) genotype disrupts omega-3 fatty acids (n - 3 PUFA) metabolism. Fatty Acids, Omega-3 119-138 pumilio RNA binding family member 3 Homo sapiens 146-150 24679942-0 2014 Association of n-3 polyunsaturated fatty acids with soluble thrombomodulin as a marker of endothelial damage: a cross-sectional pilot study. Fatty Acids, Omega-3 15-46 thrombomodulin Homo sapiens 60-74 24879443-2 2014 Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-type FABP (E-FABP) has an affinity for n-3 fatty acids. Fatty Acids, Omega-3 160-175 fatty acid binding protein 5, epidermal Mus musculus 111-130 24879443-2 2014 Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-type FABP (E-FABP) has an affinity for n-3 fatty acids. Fatty Acids, Omega-3 160-175 fatty acid binding protein 5, epidermal Mus musculus 132-138 25122648-15 2014 Consumption of a low-fat spread enriched with PSs and different low doses of n-3 fatty acids from FO decreased TG concentrations in a dose-dependent manner and decreased LDL-C concentrations. Fatty Acids, Omega-3 77-92 component of oligomeric golgi complex 2 Homo sapiens 170-175 25726199-2 2014 Studies have linked a diet rich in n-3 fatty acids with a lower prevalence of insulin-resistance. Fatty Acids, Omega-3 35-50 insulin Homo sapiens 78-85 24096482-0 2014 mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression. Fatty Acids, Omega-3 21-52 CREB regulated transcription coactivator 1 Mus musculus 0-6 24096482-6 2014 In summary, dietary and endogenous n-3 PUFAs abrogate the activity of mTORC1/2 pathways in vitro and in vivo and prevent breast carcinogenesis, tumor growth and metastasis. Fatty Acids, Omega-3 35-44 CREB regulated transcription coactivator 1 Mus musculus 70-76 25203168-3 2014 Here we report that nutritional n-3 polyunsaturated fatty acids (PUFA) deficiency induces a chronic stress state reflected by disrupted glucocorticoid receptor (GR)-mediated signalling pathway along with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. Fatty Acids, Omega-3 32-63 nuclear receptor subfamily 3, group C, member 1 Mus musculus 136-159 25203168-3 2014 Here we report that nutritional n-3 polyunsaturated fatty acids (PUFA) deficiency induces a chronic stress state reflected by disrupted glucocorticoid receptor (GR)-mediated signalling pathway along with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. Fatty Acids, Omega-3 32-63 nuclear receptor subfamily 3, group C, member 1 Mus musculus 161-163 25133540-7 2014 CONCLUSION: Omega-3 fatty acids cause endothelium-dependent NO-mediated relaxations in coronary artery rings, which are dependent on the EPA:DHA ratio and amount, and involve an intracellular activation of the redox-sensitive PI3-kinase/Akt and MAPKs pathways to activate eNOS. Fatty Acids, Omega-3 12-31 AKT serine/threonine kinase 1 Homo sapiens 237-240 24611892-0 2014 Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation. Fatty Acids, Omega-3 9-28 insulin Homo sapiens 61-68 24611892-2 2014 Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced insulin resistance. Fatty Acids, Omega-3 17-52 insulin Homo sapiens 99-106 24611892-3 2014 The present study tested the hypothesis that the addition of n3PUFA to an intravenous lipid emulsion would limit muscle acylcarnitine accumulation and reduce the inhibitory effect of lipid overload on insulin action. Fatty Acids, Omega-3 61-67 insulin Homo sapiens 201-208 25134659-0 2014 The omega-3 fatty acid docosahexaenoic acid favorably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR(-/-) mice. Fatty Acids, Omega-3 4-22 low density lipoprotein receptor Mus musculus 134-138 25035188-7 2014 Omega-3 fatty acids alone and in combination with aripiprazole- and lithium-treated groups significantly reduced the levels of superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation products (thiobarbituric acid reactive substances) in the brain. Fatty Acids, Omega-3 0-19 catalase Mus musculus 155-163 25035188-7 2014 Omega-3 fatty acids alone and in combination with aripiprazole- and lithium-treated groups significantly reduced the levels of superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation products (thiobarbituric acid reactive substances) in the brain. Fatty Acids, Omega-3 0-19 catalase Mus musculus 165-168 25133540-7 2014 CONCLUSION: Omega-3 fatty acids cause endothelium-dependent NO-mediated relaxations in coronary artery rings, which are dependent on the EPA:DHA ratio and amount, and involve an intracellular activation of the redox-sensitive PI3-kinase/Akt and MAPKs pathways to activate eNOS. Fatty Acids, Omega-3 12-31 nitric oxide synthase 3 Homo sapiens 272-276 24997608-2 2014 Commonly consumed as fish products, dietary supplements and pharmaceuticals, omega-3-FAs have a number of health benefits ascribed to them, including reduced plasma triglyceride levels, amelioration of atherosclerosis and increased insulin sensitivity. Fatty Acids, Omega-3 77-88 insulin Homo sapiens 232-239 24794156-6 2014 Importantly, fat-1 transgenic mice also exhibited robust improvements in revascularization and angiogenesis compared to wild type littermates, suggesting a potential role for n-3 fatty acids in post-stroke cerebrovascular remodeling. Fatty Acids, Omega-3 175-190 FAT atypical cadherin 1 Mus musculus 13-18 24986865-9 2014 Instead, fish oil and fenofibrate reduced circulating and hepatic fatty acids in mice, and n-3 polyunsaturated fatty acids prevented palmitate inhibition of Sort1 protein in HepG2 cells. Fatty Acids, Omega-3 91-122 sortilin 1 Mus musculus 157-162 24866178-4 2014 Moreover, ectopic expression of fat-1, a desaturase, catalyzed the conversion of n-6 to n-3 PUFAs and produced n-3 PUFAs endogenously, also suppressed endometrial tumor cell growth and migration, and potentiated apoptosis in endometrial cancer cell lines. Fatty Acids, Omega-3 88-97 FAT atypical cadherin 1 Mus musculus 32-51 24866178-7 2014 Exogenous or endogenous n-3 PUFAs efficiently suppressed both mTOR complex 1 (mTORC1) and mTORC2 in vitro and in vivo. Fatty Acids, Omega-3 24-33 mechanistic target of rapamycin kinase Mus musculus 62-66 24866178-7 2014 Exogenous or endogenous n-3 PUFAs efficiently suppressed both mTOR complex 1 (mTORC1) and mTORC2 in vitro and in vivo. Fatty Acids, Omega-3 24-33 CREB regulated transcription coactivator 1 Mus musculus 78-84 24866178-7 2014 Exogenous or endogenous n-3 PUFAs efficiently suppressed both mTOR complex 1 (mTORC1) and mTORC2 in vitro and in vivo. Fatty Acids, Omega-3 24-33 CREB regulated transcription coactivator 2 Mus musculus 90-96 24818764-1 2014 BACKGROUND & AIMS: n-3 polyunsaturated fatty acids reduce insulin resistance, lipogenesis, and inflammation, which are features of nonalcoholic steatohepatitis (NASH). Fatty Acids, Omega-3 23-54 insulin Homo sapiens 62-69 24997608-3 2014 We reported that Gpr120 is the functional receptor for these fatty acids and that omega-3-FAs produce robust anti-inflammatory, insulin-sensitizing effects, both in vivo and in vitro, in a Gpr120-dependent manner. Fatty Acids, Omega-3 82-93 insulin Homo sapiens 128-135 25076939-3 2014 Although the whole mechanism of action is not fully described yet, it has been shown that stimulation of omega3-FA to FFAR4 is followed by receptor phosphorylation. Fatty Acids, Omega-3 105-114 free fatty acid receptor 4 Homo sapiens 118-123 24997608-3 2014 We reported that Gpr120 is the functional receptor for these fatty acids and that omega-3-FAs produce robust anti-inflammatory, insulin-sensitizing effects, both in vivo and in vitro, in a Gpr120-dependent manner. Fatty Acids, Omega-3 82-93 free fatty acid receptor 4 Mus musculus 189-195 25049337-2 2014 Fat-1 transgenic mice expressing Caenorhabditis elegans n-3 fatty acid desaturase, which is capable of producing n-3 PUFAs from n-6 PUFAs, exhibited resistance to pressure overload-induced inflammation and fibrosis, as well as reduced cardiac function. Fatty Acids, Omega-3 113-122 FAT atypical cadherin 1 Mus musculus 0-5 25076939-7 2014 In this review, we summarize the current knowledge about the interaction of omega3-FAs with FFAR4 and the consequent opportunities for the application of omega3-FAs and possible FFAR4 targets. Fatty Acids, Omega-3 76-86 free fatty acid receptor 4 Homo sapiens 92-97 25076939-7 2014 In this review, we summarize the current knowledge about the interaction of omega3-FAs with FFAR4 and the consequent opportunities for the application of omega3-FAs and possible FFAR4 targets. Fatty Acids, Omega-3 76-86 free fatty acid receptor 4 Homo sapiens 178-183 25076939-7 2014 In this review, we summarize the current knowledge about the interaction of omega3-FAs with FFAR4 and the consequent opportunities for the application of omega3-FAs and possible FFAR4 targets. Fatty Acids, Omega-3 154-164 free fatty acid receptor 4 Homo sapiens 92-97 27152159-4 2014 We have recently shown that GPR120 acts as a physiological receptor of omega-3 fatty acid in macrophages and adipocytes, which mediate potent anti-inflammatory and insulin-sensitizing effects. Fatty Acids, Omega-3 71-89 free fatty acid receptor 4 Homo sapiens 28-34 24594225-1 2014 BACKGROUND: 17-Oxo-DHA is an endogenous electrophilic derivative of the omega-3 fatty acid docosahexaenoic acid (DHA) which is generated in activated macrophages by the action of cyclooxygenase-2. Fatty Acids, Omega-3 72-90 prostaglandin-endoperoxide synthase 2 Homo sapiens 179-195 24749811-2 2014 We hypothesize that deficiency of maternal micronutrients such as folic acid and vitamin B12 will lead to increased oxidative stress, reduced long-chain polyunsaturated fatty acids, and altered expression of peroxisome proliferator activated receptor (PPARgamma) in the placenta, and omega-3 fatty acid supplementation to these diets will increase the expression of PPARgamma. Fatty Acids, Omega-3 284-302 peroxisome proliferator-activated receptor gamma Rattus norvegicus 252-261 24749811-6 2014 Omega-3 fatty acid supplementation to a vitamin B12 deficient diet normalized the expression of PPARgamma and lowered the levels of placental TNF-alpha. Fatty Acids, Omega-3 0-18 peroxisome proliferator-activated receptor gamma Rattus norvegicus 96-105 24749811-6 2014 Omega-3 fatty acid supplementation to a vitamin B12 deficient diet normalized the expression of PPARgamma and lowered the levels of placental TNF-alpha. Fatty Acids, Omega-3 0-18 tumor necrosis factor Rattus norvegicus 142-151 27152159-4 2014 We have recently shown that GPR120 acts as a physiological receptor of omega-3 fatty acid in macrophages and adipocytes, which mediate potent anti-inflammatory and insulin-sensitizing effects. Fatty Acids, Omega-3 71-89 insulin Homo sapiens 164-171 27152159-6 2014 In this review paper, we discuss omega-3 fatty acid-sensing GPR120 and highlight the potential outcomes of targeting this receptor in ameliorating disease. Fatty Acids, Omega-3 33-51 free fatty acid receptor 4 Homo sapiens 60-66 24747115-0 2014 Incremental replacement of saturated fats by n-3 fatty acids in high-fat, high-cholesterol diets reduces elevated plasma lipid levels and arterial lipoprotein lipase, macrophages and atherosclerosis in LDLR-/- mice. Fatty Acids, Omega-3 45-60 lipoprotein lipase Mus musculus 147-165 24595593-2 2014 In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Fatty Acids, Omega-3 117-135 component of oligomeric golgi complex 2 Homo sapiens 167-172 24595593-2 2014 In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Fatty Acids, Omega-3 117-135 apolipoprotein E Homo sapiens 189-193 24595593-2 2014 In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Fatty Acids, Omega-3 148-155 component of oligomeric golgi complex 2 Homo sapiens 167-172 24595593-2 2014 In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Fatty Acids, Omega-3 148-155 apolipoprotein E Homo sapiens 189-193 24875538-4 2014 Here, we report that the transgenic mice that express the fat-1 gene encoding for omega-3 fatty acid desaturase, which leads to an increase in endogenous omega-3 PUFAs and a concomitant decrease in omega-6 PUFAs, were protected from global cerebral ischemia injury. Fatty Acids, Omega-3 154-167 FAT atypical cadherin 1 Mus musculus 58-63 24621058-11 2014 Taken together, these data suggest that n-3 fatty acids influence the persistence of LTM by maintaining adequate levels of DHA and BDNF as well as by influencing the activation of NR2B and Fyn during the period of memory formation. Fatty Acids, Omega-3 40-55 brain-derived neurotrophic factor Rattus norvegicus 131-135 24621058-11 2014 Taken together, these data suggest that n-3 fatty acids influence the persistence of LTM by maintaining adequate levels of DHA and BDNF as well as by influencing the activation of NR2B and Fyn during the period of memory formation. Fatty Acids, Omega-3 40-55 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 180-184 24621058-11 2014 Taken together, these data suggest that n-3 fatty acids influence the persistence of LTM by maintaining adequate levels of DHA and BDNF as well as by influencing the activation of NR2B and Fyn during the period of memory formation. Fatty Acids, Omega-3 40-55 FYN proto-oncogene, Src family tyrosine kinase Rattus norvegicus 189-192 24923522-1 2014 We report evidence of a detailed epigenetic modification of the leptin promoter and the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), which is closely associated with the leptin gene transcription in obesity. Fatty Acids, Omega-3 99-130 leptin Mus musculus 181-187 24869970-5 2014 In these noncancer conditions, it has been reported that n-3 fatty acids act by increasing insulin sensitivity, reducing inflammatory mediators, and altering adipokine profiles and transcription factors; therefore, the plausibility of these mechanisms of action in the neoplastic state are considered. Fatty Acids, Omega-3 57-72 insulin Homo sapiens 91-98 23757305-1 2014 OBJECTIVES: omega-3 Fatty acids (FAs), natural ligands for the peroxisome proliferator-activated receptor-alpha (PPAR-alpha), attenuate parenteral nutrition-associated liver disease (PNALD). Fatty Acids, Omega-3 12-31 peroxisome proliferator activated receptor alpha Mus musculus 63-111 23757305-1 2014 OBJECTIVES: omega-3 Fatty acids (FAs), natural ligands for the peroxisome proliferator-activated receptor-alpha (PPAR-alpha), attenuate parenteral nutrition-associated liver disease (PNALD). Fatty Acids, Omega-3 12-31 peroxisome proliferator activated receptor alpha Mus musculus 113-123 24979774-0 2014 Cytochrome P450-generated metabolites derived from omega-3 fatty acids attenuate neovascularization. Fatty Acids, Omega-3 51-70 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-15 24817122-2 2014 Among these is FFA4, previously called GPR120, which responds to medium and long chain fatty acids, including health-promoting omega-3 fatty acids, which have been implicated in the regulation of metabolic and inflammatory responses. Fatty Acids, Omega-3 127-146 free fatty acid receptor 4 Homo sapiens 39-45 24911523-1 2014 The omega-3 (omega3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1beta production through poorly understood molecular mechanisms. Fatty Acids, Omega-3 4-31 interleukin 1 beta Mus musculus 99-107 24747115-0 2014 Incremental replacement of saturated fats by n-3 fatty acids in high-fat, high-cholesterol diets reduces elevated plasma lipid levels and arterial lipoprotein lipase, macrophages and atherosclerosis in LDLR-/- mice. Fatty Acids, Omega-3 45-60 low density lipoprotein receptor Mus musculus 202-206 24747115-12 2014 Even low levels of replacement of SAT by n-3 FA effectively reduce arterial lipid deposition by decreasing aortic LpL, macrophages and pro-inflammatory markers. Fatty Acids, Omega-3 41-47 lipoprotein lipase Mus musculus 114-117 24440463-11 2014 Finally, dietary supplementation of aged mice with anti-inflammatory n-3 polyunsaturated fatty acids in the form of fish oil lowered lung A20 levels and enhanced resistance, including a 100-fold reduction in bacterial titers in the lungs, to experimental challenge with S. pneumoniae. Fatty Acids, Omega-3 69-100 tumor necrosis factor, alpha-induced protein 3 Mus musculus 138-141 24643636-5 2014 Among pro- and anti-inflammatory mediators, only serum ferritin level and IL-10 to IL-6 ratio showed significant changes in favor of omega-3 supplement during the study. Fatty Acids, Omega-3 133-140 interleukin 10 Homo sapiens 74-79 24643636-5 2014 Among pro- and anti-inflammatory mediators, only serum ferritin level and IL-10 to IL-6 ratio showed significant changes in favor of omega-3 supplement during the study. Fatty Acids, Omega-3 133-140 interleukin 6 Homo sapiens 83-87 24634501-0 2014 Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway. Fatty Acids, Omega-3 8-27 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-88 24634501-2 2014 CYP enzymes also accept EPA and DHA to yield more potent vasodilatory and potentially anti-arrhythmic metabolites, suggesting that the endogenous CYP-eicosanoid profile can be favorably shifted by dietary omega-3 fatty acids. Fatty Acids, Omega-3 205-224 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 24634501-2 2014 CYP enzymes also accept EPA and DHA to yield more potent vasodilatory and potentially anti-arrhythmic metabolites, suggesting that the endogenous CYP-eicosanoid profile can be favorably shifted by dietary omega-3 fatty acids. Fatty Acids, Omega-3 205-224 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 146-149 24634501-7 2014 We propose that CYP-dependent epoxy-metabolites of EPA and DHA may function as mediators of the vasodilatory and cardioprotective effects of omega-3 fatty acids and could serve as biomarkers in clinical studies investigating the cardiovascular effects of EPA/DHA supplementation. Fatty Acids, Omega-3 141-160 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 16-19 24371037-0 2014 n-3 Polyunsaturated fatty acids modulate metabolism of insulin-sensitive tissues: implication for the prevention of type 2 diabetes. Fatty Acids, Omega-3 0-31 insulin Homo sapiens 55-62 24746838-9 2014 Most interestingly, the fat-1 model allowed us to demonstrate the role of maternal high omega-3 concentration on bone growth during the gestation and postnatal period. Fatty Acids, Omega-3 88-95 FAT atypical cadherin 1 Mus musculus 24-29 24371037-4 2014 In this context, many investigations were conducted to evaluate the potential beneficial impacts of n-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 100-131 pumilio RNA binding family member 3 Homo sapiens 137-141 25026921-0 2014 Apple flavonols and n-3 polyunsaturated fatty acid-rich fish oil lowers blood C-reactive protein in rats with hypercholesterolemia and acute inflammation. Fatty Acids, Omega-3 20-50 C-reactive protein Rattus norvegicus 78-96 24718773-0 2014 Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis. Fatty Acids, Omega-3 11-42 interleukin 17A Mus musculus 113-124 24718773-8 2014 n-3 fatty acids stimulated Th17 cells to produce lower levels of inflammatory factors, including interleukin (IL)-17, IL-22, IL-23 and stimulated Treg cells to produce higher anti-inflammatory factors, such as Foxp3. Fatty Acids, Omega-3 0-15 interleukin 22 Mus musculus 118-123 24718773-8 2014 n-3 fatty acids stimulated Th17 cells to produce lower levels of inflammatory factors, including interleukin (IL)-17, IL-22, IL-23 and stimulated Treg cells to produce higher anti-inflammatory factors, such as Foxp3. Fatty Acids, Omega-3 0-15 interleukin 23, alpha subunit p19 Mus musculus 125-130 24718773-8 2014 n-3 fatty acids stimulated Th17 cells to produce lower levels of inflammatory factors, including interleukin (IL)-17, IL-22, IL-23 and stimulated Treg cells to produce higher anti-inflammatory factors, such as Foxp3. Fatty Acids, Omega-3 0-15 forkhead box P3 Mus musculus 210-215 23517921-0 2014 Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes. Fatty Acids, Omega-3 6-20 insulin Homo sapiens 52-59 24726616-6 2014 Following FO supplementation n-3 polyunsaturated fatty acid (n-3 PUFA) muscle lipid composition was increased from W0 to W2 and continued to rise at W4. Fatty Acids, Omega-3 29-59 pumilio RNA binding family member 3 Homo sapiens 65-69 23517921-1 2014 OBJECTIVE: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. Fatty Acids, Omega-3 77-91 insulin Homo sapiens 113-120 24729033-6 2014 The nuclear form of the mutant SREBP-1c was induced by delipidated condition and suppressed by eicosapentaenoic acid, an n-3 PUFA, but not by sterols. Fatty Acids, Omega-3 121-129 sterol regulatory element binding transcription factor 1 Mus musculus 31-39 24449365-1 2014 Dietary n-3 polyunsaturated fatty acid (n-3 PUFA) supplementation is postulated to have positive effects on fertility. Fatty Acids, Omega-3 8-38 PUFA Bos taurus 44-48 24916550-3 2014 Based on previous literature, it was hypothesized that these would be adversely impacted by liver function parameters, and adiponectin levels would be positively correlated with phospholipid Omega-3 fatty acids. Fatty Acids, Omega-3 191-210 adiponectin, C1Q and collagen domain containing Homo sapiens 123-134 24587285-9 2014 Omega-3 fatty acids supplementation to this group normalized (p<0.05) levels of both PPARalpha and PPARgamma but reduced (p<0.05) SREBP-1c, LXRalpha and RXRalpha expression. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Rattus norvegicus 88-97 24786451-4 2014 The fat-1 gene, which is absent in mammals, can add a double bond into an unsaturated fatty acid hydrocarbon chain and convert omega-6 to omega-3 fatty acids. Fatty Acids, Omega-3 138-157 FAT atypical cadherin 1 Mus musculus 4-9 23575879-7 2014 Supplementation with omega-3 FA but not placebo significantly reduced elevated FSAP concentration. Fatty Acids, Omega-3 21-31 hyaluronan binding protein 2 Homo sapiens 79-83 23575879-10 2014 The possible effects of omega-3 FA on clinical AF potential could be linked with modulation of circulating FSAP levels. Fatty Acids, Omega-3 24-34 hyaluronan binding protein 2 Homo sapiens 107-111 24378994-8 2014 In conclusion, the results point out that STZ-diabetic rats benefit from n-3 PUFA consumption particularly because of the attenuation of myocardial Cx43 abnormalities that most likely contributes to improvement of cardiac function. Fatty Acids, Omega-3 73-81 gap junction protein, alpha 1 Rattus norvegicus 148-152 24262133-0 2014 GPR120 on Kupffer cells mediates hepatoprotective effects of omega3-fatty acids. Fatty Acids, Omega-3 61-79 free fatty acid receptor 4 Mus musculus 0-6 24360505-0 2014 Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. Fatty Acids, Omega-3 0-18 5-hydroxytryptamine receptor 1A Rattus norvegicus 167-173 24360505-0 2014 Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. Fatty Acids, Omega-3 0-18 adrenoceptor alpha 2A Rattus norvegicus 178-205 24587285-11 2014 Omega-3 fatty acids supplementation to this group reduced (p<0.05) PPARalpha, SREBP-1c and RXRalpha expression. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Rattus norvegicus 70-79 24587285-11 2014 Omega-3 fatty acids supplementation to this group reduced (p<0.05) PPARalpha, SREBP-1c and RXRalpha expression. Fatty Acids, Omega-3 0-19 sterol regulatory element binding transcription factor 1 Rattus norvegicus 81-89 24736647-2 2014 The generation of electrophilic alpha,beta-unsaturated ketone derivatives of the omega-3 PUFAs docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) in activated human macrophages is catalyzed by cyclooxygenase-2 (Cox-2). Fatty Acids, Omega-3 81-94 prostaglandin-endoperoxide synthase 2 Homo sapiens 201-217 24736647-2 2014 The generation of electrophilic alpha,beta-unsaturated ketone derivatives of the omega-3 PUFAs docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) in activated human macrophages is catalyzed by cyclooxygenase-2 (Cox-2). Fatty Acids, Omega-3 81-94 prostaglandin-endoperoxide synthase 2 Homo sapiens 219-224 24860731-4 2014 The inclusion of omega-3 FA in diet could normalize the levels of brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival of neuronal cells. Fatty Acids, Omega-3 17-27 brain derived neurotrophic factor Homo sapiens 66-99 24860731-4 2014 The inclusion of omega-3 FA in diet could normalize the levels of brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival of neuronal cells. Fatty Acids, Omega-3 17-27 brain derived neurotrophic factor Homo sapiens 101-105 24674717-5 2014 At least in the periphery, omega-3 fatty acids and their receptor, G-protein coupled receptor 120 (GPR120), have emerged as putative targets. Fatty Acids, Omega-3 27-46 free fatty acid receptor 4 Rattus norvegicus 99-105 24593295-0 2014 Correlation between n-3 polyunsaturated fatty acids consumption and BDNF peripheral levels in adolescents. Fatty Acids, Omega-3 20-51 brain derived neurotrophic factor Homo sapiens 68-72 24593295-2 2014 The study of factors associated with both BDNF levels and mental disorders, such as n-3 polyunsaturated fatty acids (n-3 PUFAs), may help to elucidate the mechanisms mediating the relationship between the two variables. Fatty Acids, Omega-3 84-115 brain derived neurotrophic factor Homo sapiens 42-46 23478748-0 2014 Omega-3 fatty acid supplementation changes intracellular phospholipase A2 activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis. Fatty Acids, Omega-3 0-18 phospholipase A2 group IB Homo sapiens 57-73 23478748-4 2014 Here, we report on the effects of omega-3 PUFA supplementation on intracellular phospholipase A2 (inPLA(2)) activity, the main enzymes regulating phospholipid metabolism, as well as on peripheral membrane lipid profiles in the individuals who participated in this randomized placebo-controlled trial. Fatty Acids, Omega-3 34-46 phospholipase A2 group IB Homo sapiens 80-96 24587285-11 2014 Omega-3 fatty acids supplementation to this group reduced (p<0.05) PPARalpha, SREBP-1c and RXRalpha expression. Fatty Acids, Omega-3 0-19 retinoid X receptor alpha Rattus norvegicus 94-102 24587285-9 2014 Omega-3 fatty acids supplementation to this group normalized (p<0.05) levels of both PPARalpha and PPARgamma but reduced (p<0.05) SREBP-1c, LXRalpha and RXRalpha expression. Fatty Acids, Omega-3 0-19 peroxisome proliferator-activated receptor gamma Rattus norvegicus 102-111 24587285-9 2014 Omega-3 fatty acids supplementation to this group normalized (p<0.05) levels of both PPARalpha and PPARgamma but reduced (p<0.05) SREBP-1c, LXRalpha and RXRalpha expression. Fatty Acids, Omega-3 0-19 sterol regulatory element binding transcription factor 1 Rattus norvegicus 136-144 24587285-9 2014 Omega-3 fatty acids supplementation to this group normalized (p<0.05) levels of both PPARalpha and PPARgamma but reduced (p<0.05) SREBP-1c, LXRalpha and RXRalpha expression. Fatty Acids, Omega-3 0-19 nuclear receptor subfamily 1, group H, member 3 Rattus norvegicus 146-154 24587285-9 2014 Omega-3 fatty acids supplementation to this group normalized (p<0.05) levels of both PPARalpha and PPARgamma but reduced (p<0.05) SREBP-1c, LXRalpha and RXRalpha expression. Fatty Acids, Omega-3 0-19 retinoid X receptor alpha Rattus norvegicus 159-167 24211484-0 2014 Elevated tissue omega-3 fatty acid status prevents age-related glucose intolerance in fat-1 transgenic mice. Fatty Acids, Omega-3 16-34 FAT atypical cadherin 1 Mus musculus 86-91 24505395-0 2014 Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor alpha: a meta-analysis. Fatty Acids, Omega-3 25-56 C-reactive protein Homo sapiens 60-78 24505395-0 2014 Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor alpha: a meta-analysis. Fatty Acids, Omega-3 25-56 interleukin 6 Homo sapiens 80-125 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 15-24 tumor necrosis factor Homo sapiens 147-156 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 15-24 interleukin 6 Homo sapiens 158-162 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 15-24 C-reactive protein Homo sapiens 167-170 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 84-93 tumor necrosis factor Homo sapiens 147-156 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 84-93 interleukin 6 Homo sapiens 158-162 24505395-4 2014 Marine-derived n-3 PUFAs supplementation showed a lowering effect on Marine-derived n-3 PUFAs supplementation had a significant lowering effect on TNF-alpha, IL-6 and CRP in three groups of subjects (subjects with chronic non-autoimmune disease, subjects with chronic autoimmune disease and healthy subjects). Fatty Acids, Omega-3 84-93 C-reactive protein Homo sapiens 167-170 24505395-8 2014 The effect of marine-derived n-3 PUFAs from dietary intake was only assessed in subjects with chronic non-autoimmune disease, and a significant lowering effect was observed on IL-6, but not on CRP and TNF-alpha. Fatty Acids, Omega-3 29-38 interleukin 6 Homo sapiens 176-180 24505395-9 2014 CONCLUSIONS: Marine-derived n-3 PUFAs supplementation had a significant lowering effect on CRP, IL-6 and TNF-alpha level. Fatty Acids, Omega-3 28-37 C-reactive protein Homo sapiens 91-94 24505395-9 2014 CONCLUSIONS: Marine-derived n-3 PUFAs supplementation had a significant lowering effect on CRP, IL-6 and TNF-alpha level. Fatty Acids, Omega-3 28-37 interleukin 6 Homo sapiens 96-100 24505395-9 2014 CONCLUSIONS: Marine-derived n-3 PUFAs supplementation had a significant lowering effect on CRP, IL-6 and TNF-alpha level. Fatty Acids, Omega-3 28-37 tumor necrosis factor Homo sapiens 105-114 23546614-0 2014 The consumption of n-3 polyunsaturated fatty acids differentially modulates gene expression of peroxisome proliferator-activated receptor alpha and gamma and hypoxia-inducible factor 1 alpha in subcutaneous adipose tissue of obese adolescents. Fatty Acids, Omega-3 19-50 hypoxia inducible factor 1 subunit alpha Homo sapiens 95-190 24290517-2 2014 However, the relationship between n-3 FAs and beta-catenin, one of the key components of the Wnt signaling pathway, in mouse breast cancer remains poorly characterized. Fatty Acids, Omega-3 34-41 catenin (cadherin associated protein), beta 1 Mus musculus 46-58 23492103-6 2014 Restoration of hepatic omega-3 content in transgenic fat-1 mice expressing an omega-3 desaturase, which allows the endogenous conversion of omega-6 into omega-3 fatty acids, produced a significant reduction in hepatic insulin resistance, steatosis, macrophage infiltration, necroinflammation and lipid peroxidation, accompanied by attenuated expression of genes involved in inflammation, fatty acid uptake and lipogenesis. Fatty Acids, Omega-3 23-30 FAT atypical cadherin 1 Mus musculus 53-58 23492103-6 2014 Restoration of hepatic omega-3 content in transgenic fat-1 mice expressing an omega-3 desaturase, which allows the endogenous conversion of omega-6 into omega-3 fatty acids, produced a significant reduction in hepatic insulin resistance, steatosis, macrophage infiltration, necroinflammation and lipid peroxidation, accompanied by attenuated expression of genes involved in inflammation, fatty acid uptake and lipogenesis. Fatty Acids, Omega-3 153-172 FAT atypical cadherin 1 Mus musculus 53-58 24048769-0 2014 The high-level accumulation of n-3 polyunsaturated fatty acids in transgenic pigs harboring the n-3 fatty acid desaturase gene from Caenorhabditis briggsae. Fatty Acids, Omega-3 31-62 stearoyl-CoA desaturase Sus scrofa 100-121 24365276-4 2014 Moreover, studies using animal models have demonstrated that dietary saturated fats raise blood lipid (cholesterol and triglycerides) levels only when the diet is deficient in omega-3 polyunsaturated fatty acids (n-3PUFA). Fatty Acids, Omega-3 176-211 pumilio RNA binding family member 3 Homo sapiens 216-220 24276408-1 2014 omega-3 polyunsaturated fatty acids (n-3 PUFA), in particular the marine-derived forms eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been demonstrated to affect cancer cell replication, the cell cycle and cell death. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 24622833-0 2014 The effect of omega-3 fatty acids on expression of connexin-40 in Wistar rat aorta after lipopolysaccharide administration. Fatty Acids, Omega-3 14-33 gap junction protein, alpha 5 Rattus norvegicus 51-62 23962659-1 2014 We have demonstrated previously that n-3 PUFA endogenously produced by fat-1 transgenic mice regulate CD4+ T-cell function by affecting the formation of lipid rafts, liquid-ordered mesodomains in the plasma membrane. Fatty Acids, Omega-3 37-45 FAT atypical cadherin 1 Mus musculus 71-76 24478369-0 2014 Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. Fatty Acids, Omega-3 0-19 nuclear factor, erythroid derived 2, like 2 Mus musculus 76-80 24478369-0 2014 Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. Fatty Acids, Omega-3 0-19 heme oxygenase 1 Mus musculus 98-114 24478369-4 2014 The present study tests the hypothesis that omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate ischemic neuronal injury by activating nuclear factor E2-related factor 2 (Nrf2) and upregulating heme oxygenase-1 (HO-1) in both in vitro and in vivo models. Fatty Acids, Omega-3 44-79 nuclear factor, erythroid derived 2, like 2 Mus musculus 177-181 24478369-4 2014 The present study tests the hypothesis that omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate ischemic neuronal injury by activating nuclear factor E2-related factor 2 (Nrf2) and upregulating heme oxygenase-1 (HO-1) in both in vitro and in vivo models. Fatty Acids, Omega-3 44-79 heme oxygenase 1 Mus musculus 200-216 24478369-4 2014 The present study tests the hypothesis that omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate ischemic neuronal injury by activating nuclear factor E2-related factor 2 (Nrf2) and upregulating heme oxygenase-1 (HO-1) in both in vitro and in vivo models. Fatty Acids, Omega-3 44-79 heme oxygenase 1 Mus musculus 218-222 24478369-4 2014 The present study tests the hypothesis that omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate ischemic neuronal injury by activating nuclear factor E2-related factor 2 (Nrf2) and upregulating heme oxygenase-1 (HO-1) in both in vitro and in vivo models. Fatty Acids, Omega-3 81-90 nuclear factor, erythroid derived 2, like 2 Mus musculus 177-181 24478369-4 2014 The present study tests the hypothesis that omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate ischemic neuronal injury by activating nuclear factor E2-related factor 2 (Nrf2) and upregulating heme oxygenase-1 (HO-1) in both in vitro and in vivo models. Fatty Acids, Omega-3 81-90 heme oxygenase 1 Mus musculus 200-216 24478369-4 2014 The present study tests the hypothesis that omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate ischemic neuronal injury by activating nuclear factor E2-related factor 2 (Nrf2) and upregulating heme oxygenase-1 (HO-1) in both in vitro and in vivo models. Fatty Acids, Omega-3 81-90 heme oxygenase 1 Mus musculus 218-222 24478369-8 2014 Further studies showed that 4-hydroxy-2E-hexenal (4-HHE), an end-product of peroxidation of n-3 PUFAs, was a more potent Nrf2 inducer than 4-hydroxy-2E-nonenal derived from n-6 PUFAs. Fatty Acids, Omega-3 92-101 nuclear factor, erythroid derived 2, like 2 Mus musculus 121-125 23962659-1 2014 We have demonstrated previously that n-3 PUFA endogenously produced by fat-1 transgenic mice regulate CD4+ T-cell function by affecting the formation of lipid rafts, liquid-ordered mesodomains in the plasma membrane. Fatty Acids, Omega-3 37-45 CD4 antigen Mus musculus 102-105 24246761-0 2014 Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. Fatty Acids, Omega-3 21-36 solute carrier family 9 member A1 Homo sapiens 122-126 24719886-7 2014 The results showed that the omega-3 fatty acid enriched chevon increased the omega-3 fatty acids in the rat tissues and altered PPAR-gamma and SREBP-1c genes expression. Fatty Acids, Omega-3 28-46 peroxisome proliferator-activated receptor gamma Rattus norvegicus 128-138 24012777-7 2014 The fat-1 transgenic mouse model is capable of converting n-6 to n-3 fatty acids leading to an increase in n-3 fatty acid content with a balanced n-6/n-3 fatty acid ratio in all tissues. Fatty Acids, Omega-3 65-80 FAT atypical cadherin 1 Mus musculus 4-9 24012777-7 2014 The fat-1 transgenic mouse model is capable of converting n-6 to n-3 fatty acids leading to an increase in n-3 fatty acid content with a balanced n-6/n-3 fatty acid ratio in all tissues. Fatty Acids, Omega-3 65-79 FAT atypical cadherin 1 Mus musculus 4-9 24719886-7 2014 The results showed that the omega-3 fatty acid enriched chevon increased the omega-3 fatty acids in the rat tissues and altered PPAR-gamma and SREBP-1c genes expression. Fatty Acids, Omega-3 28-46 sterol regulatory element binding transcription factor 1 Rattus norvegicus 143-151 24136824-1 2014 One mechanism of the lipid-lowering effects of the fish oil n-3 fatty acids [e.g., docosahexaenoic acid (DHA)] in cell and animal models is induced hepatic apolipoprotein B100 (apoB) presecretory degradation. Fatty Acids, Omega-3 60-75 apolipoprotein B Rattus norvegicus 177-181 24485693-0 2014 Comparison of supplementation of n-3 fatty acids from fish and flax oil on cytokine gene expression and growth of milk-fed Holstein calves. Fatty Acids, Omega-3 33-48 Weaning weight-maternal milk Bos taurus 114-118 24485693-3 2014 The objective of this study was to compare supplementation of n-3 fatty acids from fish and flax oil on gene expression of whole blood cells and growth of milk-fed Holstein calves. Fatty Acids, Omega-3 62-77 Weaning weight-maternal milk Bos taurus 155-159 24358308-0 2013 A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. Fatty Acids, Omega-3 26-44 low density lipoprotein receptor Mus musculus 122-126 24287500-11 2014 However, we observed evidence consistent with recessive modes of association and that an effect of CX3CR1 variants may depend on other factors including dietary intake of omega-3 fatty acids, obesity, and genotypes at CFH Y402H and C3 R102G. Fatty Acids, Omega-3 171-190 C-X3-C motif chemokine receptor 1 Homo sapiens 99-105 24640977-4 2014 Preclinically, the first line of defense is behavior-lowering peripheral insulin resistance (e.g., physical exercise and a Mediterranean diet supplemented with foods rich in flavonoids, curcumin and omega-3 fatty acids). Fatty Acids, Omega-3 199-218 insulin Homo sapiens 73-80 25477716-3 2014 Excessive diets in refined carbohydrates and saturated fats are risk factors for insulin resistance, but calcium, magnesium, vitamin-D, and the omega-3 fatty acids likely protect against inflammation and insulin resistance. Fatty Acids, Omega-3 45-59 insulin Homo sapiens 81-88 25477716-3 2014 Excessive diets in refined carbohydrates and saturated fats are risk factors for insulin resistance, but calcium, magnesium, vitamin-D, and the omega-3 fatty acids likely protect against inflammation and insulin resistance. Fatty Acids, Omega-3 144-163 insulin Homo sapiens 204-211 24564652-2 2014 Currently, we use hyperthyroid and hypothyroid rats as "models of a diseased organism" and analyze whether n-3 polyunsaturated fatty acids (n-3 PUFA) administration can ameliorate TH-induced pathophysiological changes. Fatty Acids, Omega-3 107-138 pumilio RNA binding family member 3 Homo sapiens 144-148 24564669-2 2014 This review focuses on the effects of long-chain n-3 polyunsaturated fatty acids (omega-3) on insulin sensitivity and glucose homeostasis, which are improved by omega-3 in many animal models of metabolic syndrome, but remain frequently unaffected in humans. Fatty Acids, Omega-3 82-89 insulin Homo sapiens 94-101 24564669-2 2014 This review focuses on the effects of long-chain n-3 polyunsaturated fatty acids (omega-3) on insulin sensitivity and glucose homeostasis, which are improved by omega-3 in many animal models of metabolic syndrome, but remain frequently unaffected in humans. Fatty Acids, Omega-3 161-168 insulin Homo sapiens 94-101 24564669-4 2014 Most animal experiments document beneficial effects of omega-3 on insulin sensitivity and glucose metabolism even under conditions of established obesity and insulin resistance. Fatty Acids, Omega-3 55-62 insulin Homo sapiens 66-73 25059053-5 2014 The use of high doses of omega-3 fatty acids (600 mg EPA and 400 mg DHA per kg of animal weight per day coming through fish oil) did not affect the activity of ALT and GGT, but increased AST serum activity (0.47 +/- 0.04 micromoles/min per mg protein) and the de Ritis ratio (2.53 +/- 0.23). Fatty Acids, Omega-3 25-44 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 187-190 24129365-0 2013 Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management. Fatty Acids, Omega-3 0-19 adiponectin, C1Q and collagen domain containing Homo sapiens 48-59 24358199-5 2013 Analysis of total saponified fatty acids revealed that the residual EWAT of Bscl2(-/-) mice contained a much higher proportion of oleic 18:1n9 acid concomitant with a lower proportion of palmitic 16:0 acid, as well as increased n3- polyunsaturated fatty acids (PUFA) remodeling. Fatty Acids, Omega-3 228-259 Berardinelli-Seip congenital lipodystrophy 2 (seipin) Mus musculus 76-81 23892603-0 2013 Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Fatty Acids, Omega-3 0-35 mitogen-activated protein kinase 3 Homo sapiens 125-131 24129365-0 2013 Omega-3 fatty acids: a review of the effects on adiponectin and leptin and potential implications for obesity management. Fatty Acids, Omega-3 0-19 leptin Homo sapiens 64-70 24129365-6 2013 This review explores animal and human data relating to the effects of omega-3 fatty acids (marine lipids) on adiponectin and leptin, considering plausible mechanisms and potential implications for obesity management. Fatty Acids, Omega-3 70-89 adiponectin, C1Q and collagen domain containing Homo sapiens 109-120 24129365-6 2013 This review explores animal and human data relating to the effects of omega-3 fatty acids (marine lipids) on adiponectin and leptin, considering plausible mechanisms and potential implications for obesity management. Fatty Acids, Omega-3 70-89 leptin Homo sapiens 125-131 24129365-7 2013 Current evidence suggests a positive, dose-dependent relationship between omega-3 fatty acid intake and circulating levels of adiponectin. Fatty Acids, Omega-3 74-92 adiponectin, C1Q and collagen domain containing Homo sapiens 126-137 24129365-9 2013 In non-obese subjects, omega-3 is observed to decrease circulating levels of leptin; however, omega-3-associated increases in leptin levels have been observed in obese subjects. Fatty Acids, Omega-3 23-30 leptin Homo sapiens 77-83 24129365-9 2013 In non-obese subjects, omega-3 is observed to decrease circulating levels of leptin; however, omega-3-associated increases in leptin levels have been observed in obese subjects. Fatty Acids, Omega-3 94-101 leptin Homo sapiens 126-132 24052576-0 2013 Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. Fatty Acids, Omega-3 34-65 erb-b2 receptor tyrosine kinase 2 Mus musculus 18-22 24052576-0 2013 Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. Fatty Acids, Omega-3 34-65 FAT atypical cadherin 1 Mus musculus 92-97 23957239-5 2013 Statins, fibrates, niacin and n-3 fatty acids may influence circulating adiponectin levels, indicating that adiponectin may mediate some of the metabolic effects of these agents. Fatty Acids, Omega-3 30-45 adiponectin, C1Q and collagen domain containing Homo sapiens 72-83 23845215-8 2013 Prenatal omega 3 fatty acid supplementation normalized DHA, BDNF and NGF while long term supplementation was not beneficial only when micronutrients were imbalanced. Fatty Acids, Omega-3 9-27 brain-derived neurotrophic factor Rattus norvegicus 60-64 23906790-1 2013 The effect of numerous anticancer drugs on breast cancer cell lines and rodent mammary tumors can be enhanced by a treatment with long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as docosahexaenoic acid (DHA, 22:6n-3) which is a natural ligand of peroxisome proliferator-activated receptors (PPAR). Fatty Acids, Omega-3 141-172 pumilio RNA binding family member 3 Homo sapiens 178-182 23906790-1 2013 The effect of numerous anticancer drugs on breast cancer cell lines and rodent mammary tumors can be enhanced by a treatment with long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as docosahexaenoic acid (DHA, 22:6n-3) which is a natural ligand of peroxisome proliferator-activated receptors (PPAR). Fatty Acids, Omega-3 141-172 peroxisome proliferator activated receptor alpha Homo sapiens 257-300 23906790-1 2013 The effect of numerous anticancer drugs on breast cancer cell lines and rodent mammary tumors can be enhanced by a treatment with long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as docosahexaenoic acid (DHA, 22:6n-3) which is a natural ligand of peroxisome proliferator-activated receptors (PPAR). Fatty Acids, Omega-3 141-172 peroxisome proliferator activated receptor alpha Homo sapiens 302-306 24164329-1 2013 Omega-3 polyunsaturated fatty acids (n-3 PUFA) enriched eggs have a growing market share in the egg industry. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 24195588-11 2013 CONCLUSION: The significant decrease in AA/EPA ratio indicates that insulin analog initiation therapy has anti-inflammatory properties by favoring the increase of n3 fatty acid EPA. Fatty Acids, Omega-3 163-176 insulin Homo sapiens 68-75 24074869-0 2013 NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Fatty Acids, Omega-3 81-100 nuclear receptor co-repressor 1 Mus musculus 0-4 24447198-4 2013 Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation may reduce symptoms of major depressive disorder and perinatal depression. Fatty Acids, Omega-3 0-34 pumilio RNA binding family member 3 Homo sapiens 40-44 24274717-3 2013 Fatty acid binding protein 7 (FABP7), which is a cellular chaperone for a variety of omega-3 fatty acids, is a known marker for neural stem cells. Fatty Acids, Omega-3 85-104 fatty acid binding protein 7 Homo sapiens 0-28 24274717-3 2013 Fatty acid binding protein 7 (FABP7), which is a cellular chaperone for a variety of omega-3 fatty acids, is a known marker for neural stem cells. Fatty Acids, Omega-3 85-104 fatty acid binding protein 7 Homo sapiens 30-35 24294136-0 2013 A high-fat diet enriched with low omega-6 to omega-3 fatty acid ratio reduced fat cellularity and plasma leptin concentration in Sprague-Dawley rats. Fatty Acids, Omega-3 45-63 leptin Rattus norvegicus 105-111 23683266-0 2013 Omega-3 fatty acid therapy reduces triglycerides and interleukin-6 in hypertriglyeridemic HIV patients. Fatty Acids, Omega-3 0-18 interleukin 6 Homo sapiens 53-66 24095588-6 2013 After six month of intervention, the patients on omega 3 fatty acids had lower GPx-1 (33.5+-13.4 versus 46.6 +-17.6, p<0.01) and Cu/Zn-SOD (1070+-600 versus 1470+-690 p<0.05) activities than at baseline. Fatty Acids, Omega-3 49-68 glutathione peroxidase 1 Homo sapiens 79-84 24113544-5 2013 CES-D-K scores and levels of iNOS and tumor necrosis factor (TNF)-alpha were negatively associated with Omega-3 Index (erythrocyte levels of eicosapentaenoic acid and docosahexaenoic acid) after adjusting for confounding factors. Fatty Acids, Omega-3 104-111 nitric oxide synthase 2 Homo sapiens 29-33 24113544-5 2013 CES-D-K scores and levels of iNOS and tumor necrosis factor (TNF)-alpha were negatively associated with Omega-3 Index (erythrocyte levels of eicosapentaenoic acid and docosahexaenoic acid) after adjusting for confounding factors. Fatty Acids, Omega-3 104-111 tumor necrosis factor Homo sapiens 38-71 24060958-8 2013 Statins are the cornerstone of treatment, followed by fibrates and n-3 fatty acids, to achieve recommended therapeutic levels of plasma LDL cholesterol, non-HDL cholesterol, and apolipoprotein (apo) B-100. Fatty Acids, Omega-3 67-82 apolipoprotein B Homo sapiens 178-204 24043885-4 2013 Dimerization of TLR2 with TLR1 was inhibited by the n-3 fatty acid docosahexaenoic acid. Fatty Acids, Omega-3 52-66 toll like receptor 2 Homo sapiens 16-20 24043885-4 2013 Dimerization of TLR2 with TLR1 was inhibited by the n-3 fatty acid docosahexaenoic acid. Fatty Acids, Omega-3 52-66 toll like receptor 1 Homo sapiens 26-30 24075775-1 2013 OBJECTIVE: Docosahexaenoic acid (DHA), a member of n-3 polyunsaturated fatty acids (n-3 PUFA) is a potent regulator of molecular events implicated in cardiovascular health. Fatty Acids, Omega-3 51-82 pumilio RNA binding family member 3 Homo sapiens 88-92 23963508-0 2013 Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. Fatty Acids, Omega-3 13-28 brain-derived neurotrophic factor Rattus norvegicus 131-164 23958863-6 2013 A comparative lipidomic analysis of the crfad7 mutant and the wild type revealed reductions in all omega-3 fatty acid-containing plastidic and extraplastidic glycerolipid molecular species. Fatty Acids, Omega-3 99-117 uncharacterized protein Chlamydomonas reinhardtii 40-46 23958863-8 2013 Transformation of the crfad7 plastidial genome with a codon-optimized CrFAD7 restored the omega-3 fatty acid content of both plastidic and extraplastidic lipids. Fatty Acids, Omega-3 90-108 uncharacterized protein Chlamydomonas reinhardtii 22-28 23958863-8 2013 Transformation of the crfad7 plastidial genome with a codon-optimized CrFAD7 restored the omega-3 fatty acid content of both plastidic and extraplastidic lipids. Fatty Acids, Omega-3 90-108 uncharacterized protein Chlamydomonas reinhardtii 70-76 23958863-9 2013 These results show that CrFAD7 is the only omega-3 fatty acid desaturase expressed in C. reinhardtii, and we discuss possible mechanisms of how a plastid-located desaturase may impact the omega-3 fatty acid content of extraplastidic lipids. Fatty Acids, Omega-3 43-61 uncharacterized protein Chlamydomonas reinhardtii 24-30 23719203-8 2013 Moreover, the omega-3 diet normalized MyHC profiles in SHR at early stage of disease and old nonhypertensive rats, but failed to do so in old SHR at late stage of disease. Fatty Acids, Omega-3 14-21 myosin heavy chain 13 Rattus norvegicus 38-42 23756387-1 2013 BACKGROUND/OBJECTIVES: Studies suggest that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFA) in pregnancy have an impact on birth weight, but only few have investigated the effect on early fetal growth. Fatty Acids, Omega-3 61-92 pumilio RNA binding family member 3 Homo sapiens 98-102 23528972-0 2013 Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. Fatty Acids, Omega-3 129-148 thrombospondin 1 Homo sapiens 14-30 23528972-8 2013 These results suggest that supplementation with dietary omega-3 fatty acids could potentially be beneficial to adipose tissue in obesity by reducing TSP-1 and fibrosis. Fatty Acids, Omega-3 56-75 thrombospondin 1 Homo sapiens 149-154 23834646-0 2013 Attenuation of rat chronic small bowel allograft rejection by n-3 polyunsaturated fatty acids is associated with reduced expression of graft IL-15. Fatty Acids, Omega-3 62-93 interleukin 15 Rattus norvegicus 141-146 23933981-11 2013 The severity of EAE was attenuated in mice given the amyotrophic lateral sclerosis drug riluzole or fed a diet enriched with linseed oil (which contains the TREK-1 activating omega-3 fatty acid alpha-linolenic acid). Fatty Acids, Omega-3 175-193 potassium channel, subfamily K, member 2 Mus musculus 157-163 23302662-10 2013 Conversely, a DP reflecting a high n-6:n-3 fatty acid intake ratio was positively and significantly associated with elevated CRP (adjusted OR 1 15; 95% CI 1 00, 1 32). Fatty Acids, Omega-3 39-53 C-reactive protein Homo sapiens 125-128 23994161-0 2013 Endogenous synthesis of n-3 PUFA modifies fatty acid composition of kidney phospholipids and eicosanoid levels in the fat-1 mouse. Fatty Acids, Omega-3 24-32 FAT atypical cadherin 1 Mus musculus 118-123 23994161-2 2013 Wild-type and heterozygous fat-1 mice, capable of synthesizing n-3 PUFA endogenously, were given diets enriched in either n-3 or n-6 PUFA in a 2x2 factorial design and terminated after 12 weeks. Fatty Acids, Omega-3 63-71 FAT atypical cadherin 1 Mus musculus 27-32 23594712-2 2013 RECENT FINDINGS: The effects of n-3 FA on modulating arterial lipoprotein lipase levels link to changes in lipid deposition in the arterial wall. Fatty Acids, Omega-3 32-38 lipoprotein lipase Homo sapiens 62-80 23092637-6 2013 RESULTS: The rs2179706 SNP interacted with plasma concentration of n - 3 polyunsaturated fatty acids (n - 3 PUFA), which were significantly associated with plasma concentrations of fasting insulin, peptide C, and HOMA-IR. Fatty Acids, Omega-3 67-100 pumilio RNA binding family member 3 Homo sapiens 108-112 23092637-6 2013 RESULTS: The rs2179706 SNP interacted with plasma concentration of n - 3 polyunsaturated fatty acids (n - 3 PUFA), which were significantly associated with plasma concentrations of fasting insulin, peptide C, and HOMA-IR. Fatty Acids, Omega-3 67-100 insulin Homo sapiens 189-196 23723388-0 2013 Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta. Fatty Acids, Omega-3 17-35 CD59 molecule Rattus norvegicus 66-75 23613529-8 2013 Finally, the products of lipoxygenases and omega-3 fatty acids among other molecules, such as divalent cations, have also been shown to endogenously regulate TRPV1 activity. Fatty Acids, Omega-3 43-62 transient receptor potential cation channel subfamily V member 1 Homo sapiens 158-163 23995083-0 2013 bZIP67 regulates the omega-3 fatty acid content of Arabidopsis seed oil by activating fatty acid desaturase3. Fatty Acids, Omega-3 21-39 fatty acid desaturase 3 Arabidopsis thaliana 86-108 24116330-3 2013 AIM: This study was intended to assess the effects of antioxidants; alpha lipoic acid (ALA), omega 3 fatty acid and vitamin E on parameters of insulin sensitivity (blood glucose and HbA1c) in patients of type 2 diabetes mellitus with documented insulin resistance. Fatty Acids, Omega-3 93-111 insulin Homo sapiens 143-150 24116330-15 2013 CONCLUSION: ALA, Omega 3 fatty acid and vitamin E can be used as add on therapy in patients with type 2 diabetes mellitus to improve insulin sensitivity and lipid metabolism. Fatty Acids, Omega-3 17-35 insulin Homo sapiens 133-140 23806688-1 2013 n-3-Polyunsaturated fatty acids (PUFAs) protect against myocardial infarction, arteriosclerosis and high blood pressure by stimulating endothelial nitric oxide synthase (eNOS) to increase nitric oxide (NO) production. Fatty Acids, Omega-3 0-31 nitric oxide synthase 3 Homo sapiens 135-168 23806688-1 2013 n-3-Polyunsaturated fatty acids (PUFAs) protect against myocardial infarction, arteriosclerosis and high blood pressure by stimulating endothelial nitric oxide synthase (eNOS) to increase nitric oxide (NO) production. Fatty Acids, Omega-3 33-38 nitric oxide synthase 3 Homo sapiens 135-168 23677863-0 2013 Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. Fatty Acids, Omega-3 30-60 vascular endothelial growth factor A Mus musculus 115-119 23677863-0 2013 Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. Fatty Acids, Omega-3 30-60 chemokine (C-C motif) ligand 2 Mus musculus 149-153 23677863-0 2013 Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. Fatty Acids, Omega-3 30-60 chemokine (C-X3-C motif) receptor 1 Mus musculus 154-160 23827131-0 2013 Low-fat diet with omega-3 fatty acids increases plasma insulin-like growth factor concentration in healthy postmenopausal women. Fatty Acids, Omega-3 18-37 insulin Homo sapiens 55-62 23827131-8 2013 Low-fat diet with high n-3 fatty acids may increase circulating IGF-I concentrations without adversely affecting insulin sensitivity in healthy individuals. Fatty Acids, Omega-3 23-38 insulin like growth factor 1 Homo sapiens 64-69 23843691-0 2013 Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice. Fatty Acids, Omega-3 11-42 FAT atypical cadherin 1 Mus musculus 133-137 25867037-8 2013 The n-3 fatty acid-fortified diet was found to have potent immunopotentiating and anti-inflammatory effects in the group receiving this diet, as evidenced by total blood lymphocyte count and plasma levels of interleukin-1 beta (IL-1beta) and sialic acid on day 1 after wounding. Fatty Acids, Omega-3 4-18 interleukin 1 beta Rattus norvegicus 208-226 25867037-8 2013 The n-3 fatty acid-fortified diet was found to have potent immunopotentiating and anti-inflammatory effects in the group receiving this diet, as evidenced by total blood lymphocyte count and plasma levels of interleukin-1 beta (IL-1beta) and sialic acid on day 1 after wounding. Fatty Acids, Omega-3 4-18 interleukin 1 beta Rattus norvegicus 228-236 23528830-3 2013 Epidemiological studies suggest the benefits of omega 3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on cardiovascular health. Fatty Acids, Omega-3 48-83 pumilio RNA binding family member 3 Homo sapiens 89-93 23619236-1 2013 Activation of the transcription factor PPARgamma by the n-3 fatty acid docosahexaenoic acid (DHA) is implicated in controlling proinflammatory cytokine secretion, but the intracellular signaling pathways engaged by PPARgamma are incompletely characterized. Fatty Acids, Omega-3 56-70 peroxisome proliferator activated receptor gamma Mus musculus 39-48 23574158-4 2013 We recently discovered that the fat-1 transgenic mouse, which has enriched levels of DHA in the brain because it can convert n-6 to n-3 fatty acids, exhibits increased hippocampal neurogenesis. Fatty Acids, Omega-3 132-147 FAT atypical cadherin 1 Mus musculus 32-37 23748282-0 2013 Effects of omega-3 polyunsaturated fatty acid supplementation on serum fetuin-A levels in type 2 diabetic patients. Fatty Acids, Omega-3 11-45 alpha 2-HS glycoprotein Homo sapiens 71-79 23748282-3 2013 The aim of this study to determine the effects of omega-3 PUFA supplementation on fetuin-A and glycemic control in patients with type 2 diabetes mellitus. Fatty Acids, Omega-3 50-57 alpha 2-HS glycoprotein Homo sapiens 82-90 23426968-0 2013 Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. Fatty Acids, Omega-3 22-41 epidermal growth factor receptor Mus musculus 60-92 23426968-2 2013 Since n-3 polyunsaturated fatty acids (PUFA), specifically docosahexaenoic acid (DHA), alter EGFR signaling and suppress downstream activation of key signaling pathways, we hypothesized that DHA would be detrimental to the process of intestinal wound healing. Fatty Acids, Omega-3 6-37 epidermal growth factor receptor Mus musculus 93-97 23809158-3 2013 (2013) suggest that omega-3 fatty acids commonly found in marine oils can suppress activation of NLRP3 and NLRP1b inflammasomes. Fatty Acids, Omega-3 20-39 NLR family pyrin domain containing 3 Homo sapiens 97-102 23809162-0 2013 Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Fatty Acids, Omega-3 0-19 NLR family pyrin domain containing 3 Homo sapiens 86-91 23809162-2 2013 Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion. Fatty Acids, Omega-3 50-61 NLR family pyrin domain containing 3 Homo sapiens 166-171 23809162-2 2013 Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion. Fatty Acids, Omega-3 50-61 caspase 1 Homo sapiens 221-230 23809162-2 2013 Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion. Fatty Acids, Omega-3 50-61 interleukin 1 beta Homo sapiens 246-254 23809162-5 2013 Our results reveal a mechanism through which omega-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of omega-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases. Fatty Acids, Omega-3 45-56 NLR family pyrin domain containing 3 Homo sapiens 219-224 23425772-1 2013 OBJECTIVE: We conducted a clinical trial to examine the effect of omega-3 fatty acids in patients with cardiac syndrome X (CSX). Fatty Acids, Omega-3 66-85 NK2 homeobox 5 Homo sapiens 123-126 23425772-2 2013 We aimed to evaluate the potential impact of omega-3 fatty acids on endothelial function, oxidative stress, and symptom relief in the CSX. Fatty Acids, Omega-3 45-64 NK2 homeobox 5 Homo sapiens 134-137 23425772-9 2013 CONCLUSION: Four months of therapy with a moderate dose of omega-3 fatty acids improved the endothelial function and reduced oxidative stress in patients with CSX. Fatty Acids, Omega-3 59-78 NK2 homeobox 5 Homo sapiens 159-162 23548281-8 2013 Concentrations of n-3 fatty acids and conjugated linoleic acids in milk fat were increased by UFCPGF relative to HGF, but ALA yield was not affected. Fatty Acids, Omega-3 18-33 Weaning weight-maternal milk Bos taurus 67-71 23625116-8 2013 These results indicate that increases in plasma n-3 fatty acid levels by fish oil led to the suppression of NFkappaB activation and subsequent downregulation of TNFalpha, followed by suppression of M-CSF and RANKL. Fatty Acids, Omega-3 48-62 colony stimulating factor 1 Rattus norvegicus 198-203 23466070-0 2013 APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA). Fatty Acids, Omega-3 54-73 apolipoprotein E Homo sapiens 0-4 23328126-0 2013 Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 77-84 23328126-8 2013 The addition of omega-3 fatty acids reduced MCP-1 expression with no effect on TNF-alpha. Fatty Acids, Omega-3 16-35 C-C motif chemokine ligand 2 Homo sapiens 44-49 23328126-9 2013 In addition, omega-3 fatty acids suppressed the upregulation of adipocyte MCP-1 that occurred when adipocytes were cocultured with macrophages. Fatty Acids, Omega-3 13-32 C-C motif chemokine ligand 2 Homo sapiens 74-79 23361365-2 2013 Several epidemiological studies have reported that dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) is inversely associated with serum CRP concentration. Fatty Acids, Omega-3 69-100 C-reactive protein Homo sapiens 148-151 22902330-0 2013 Omega-3 fatty acids suppress Th2-associated cytokine gene expressions and GATA transcription factors in mast cells. Fatty Acids, Omega-3 0-19 heart and neural crest derivatives expressed 2 Mus musculus 29-32 22902330-0 2013 Omega-3 fatty acids suppress Th2-associated cytokine gene expressions and GATA transcription factors in mast cells. Fatty Acids, Omega-3 0-19 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 Mus musculus 74-78 23361365-2 2013 Several epidemiological studies have reported that dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) is inversely associated with serum CRP concentration. Fatty Acids, Omega-3 102-111 C-reactive protein Homo sapiens 148-151 23361365-4 2013 The aims of this study were to examine the effect of the n-3 PUFAs, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), on the modulation of IL-6-induced CRP expression and to explore its possible mechanisms. Fatty Acids, Omega-3 57-66 interleukin 6 Homo sapiens 150-154 23361365-4 2013 The aims of this study were to examine the effect of the n-3 PUFAs, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), on the modulation of IL-6-induced CRP expression and to explore its possible mechanisms. Fatty Acids, Omega-3 57-66 C-reactive protein Homo sapiens 163-166 23620776-9 2013 The microglia in the spinal cord of G93A-SOD1 mice treated with EPA showed a significant increase in 4-hydroxy-2-hexenal, a highly toxic aldehydic oxidation product of omega-3 fatty acids. Fatty Acids, Omega-3 168-187 superoxide dismutase 1, soluble Mus musculus 41-45 22902330-7 2013 On the contrary, omega-3 fatty acids had less significant effects on IL-4 and IL-5 and resulted in a slight decrease in IL-13 production in EL-4 T cells. Fatty Acids, Omega-3 17-36 interleukin 4 Mus musculus 69-73 23104199-13 2013 The lipoxygenase gene (alox15b) is induced by omega-3 in MSC induced to osteoblasts, and by omega-6 in MSC induced to adipocytes. Fatty Acids, Omega-3 46-53 arachidonate 15-lipoxygenase type B Homo sapiens 23-30 23658609-4 2013 We and others have reported that prostaglandin E3 (PGE3), derived from COX-2 metabolism of the omega-3 fatty acid eicosapentaenoic acid (EPA), inhibited the proliferation of human lung, colon and pancreatic cancer cells. Fatty Acids, Omega-3 95-113 mitochondrially encoded cytochrome c oxidase II Homo sapiens 71-76 22902330-7 2013 On the contrary, omega-3 fatty acids had less significant effects on IL-4 and IL-5 and resulted in a slight decrease in IL-13 production in EL-4 T cells. Fatty Acids, Omega-3 17-36 interleukin 5 Mus musculus 78-82 22902330-7 2013 On the contrary, omega-3 fatty acids had less significant effects on IL-4 and IL-5 and resulted in a slight decrease in IL-13 production in EL-4 T cells. Fatty Acids, Omega-3 17-36 interleukin 13 Mus musculus 120-125 22902330-10 2013 Taken together, omega-3 fatty acids might target mast cells to a greater extent than T cells to suppress Th2 cytokine expression by inhibiting GATAs for alleviation of allergic disease. Fatty Acids, Omega-3 16-35 heart and neural crest derivatives expressed 2 Mus musculus 105-108 22849952-0 2013 n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. Fatty Acids, Omega-3 0-15 interleukin 13 Homo sapiens 47-52 23238663-3 2013 Here we investigated whether dietary n-3 polyunsaturated fatty acid (n-3 PUFA) supplementation positively affected platelet nitroso-redox imbalance. Fatty Acids, Omega-3 37-67 pumilio RNA binding family member 3 Homo sapiens 73-77 22729967-12 2013 CONCLUSION: The results of this short-term study suggest that DPA may act as a reservoir of the major long-chain n-3 fatty acids (LC n-3 PUFA) in humans. Fatty Acids, Omega-3 113-128 pumilio RNA binding family member 3 Homo sapiens 137-141 22993129-0 2013 Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. Fatty Acids, Omega-3 0-35 vascular endothelial growth factor A Homo sapiens 43-77 22849952-1 2013 Fish oil supplementation during pregnancy has been associated with lower levels of cord blood IL-13, suggesting that the administration of n-3 fatty acids may attenuate the development of allergic disease. Fatty Acids, Omega-3 139-154 interleukin 13 Homo sapiens 94-99 22849952-2 2013 The present study aimed to investigate the mechanism by which n-3 fatty acid administration influences the production of IL-13. Fatty Acids, Omega-3 62-76 interleukin 13 Homo sapiens 121-126 22849952-10 2013 These data indicate the potential of n-3 fatty acids to attenuate IL-13 expression, and suggest that they may subsequently reduce allergic sensitisation and the development of allergic disease. Fatty Acids, Omega-3 37-52 interleukin 13 Homo sapiens 66-71 26064833-5 2013 Recently, the fat-1 transgenic mice capable of converting n-6 to n-3 polyunsaturated fatty acids (PUFAs) have been used to examine the effects of endogenous n-3 PUFAs on NAFLD. Fatty Acids, Omega-3 65-96 FAT atypical cadherin 1 Mus musculus 14-19 24757612-2 2013 This study, aims to investigate the effect of supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA) on heart function and oxidative stress biomarkers in these patients. Fatty Acids, Omega-3 67-102 pumilio RNA binding family member 3 Homo sapiens 108-112 23487785-8 2013 Slo1 BK channels are thus receptors for long-chain omega-3 fatty acids, and these fatty acids--unlike their ethyl ester derivatives--activate the channels and lower blood pressure. Fatty Acids, Omega-3 51-70 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 Mus musculus 0-4 24023466-7 2013 CONCLUSION: The beneficial effects of omega-3 supplementation in patients with CHF were not as clear as hypothesized; however, omega-3 fatty acids can result in small changes in plasma BNP levels and modest improvements in echocardiographically assessed diastolic function (Clinical trial.gov registration: NCT01227837). Fatty Acids, Omega-3 127-146 natriuretic peptide B Homo sapiens 185-188 23006546-1 2013 BACKGROUND: Protectin D1 (PD1) is an anti-inflammatory and proresolving lipid mediator biosynthesized from the omega-3 fatty acid docosahexaenoic acid (DHA). Fatty Acids, Omega-3 111-129 ribosomal protein L17 Homo sapiens 26-29 23325431-1 2013 Omega 3 polyunsaturated fatty acids (n-3 PUFA) have long been studied for their health benefits. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 23102656-8 2013 The ethanol-induced activation of cPLA2 in association with reduced iPLA2 mirrors PLA2 changes in reports of neurotrauma and also of dietary omega-3 fatty acid depletion. Fatty Acids, Omega-3 141-159 phospholipase A2 group IVA Rattus norvegicus 34-39 23102656-8 2013 The ethanol-induced activation of cPLA2 in association with reduced iPLA2 mirrors PLA2 changes in reports of neurotrauma and also of dietary omega-3 fatty acid depletion. Fatty Acids, Omega-3 141-159 phospholipase A2 group VI Rattus norvegicus 68-73 23102656-8 2013 The ethanol-induced activation of cPLA2 in association with reduced iPLA2 mirrors PLA2 changes in reports of neurotrauma and also of dietary omega-3 fatty acid depletion. Fatty Acids, Omega-3 141-159 phospholipase A2 group IB Rattus norvegicus 35-39 23467944-1 2013 OBJECTIVES: In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in rats. Fatty Acids, Omega-3 69-84 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 260-286 23467944-1 2013 OBJECTIVES: In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in rats. Fatty Acids, Omega-3 69-84 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 288-291 23467944-1 2013 OBJECTIVES: In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in rats. Fatty Acids, Omega-3 86-92 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 260-286 23467944-1 2013 OBJECTIVES: In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in rats. Fatty Acids, Omega-3 86-92 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 288-291 23148256-1 2013 In spite of the difficulties in delivering PUFA to ruminants, studies have generally indicated that the PUFA of the omega-6 (linoleic acid) and omega-3 [alpha-linolenic acid; eicosapentaenoic (EPA), C20:5 omega-3; docosahexaenoic (DHA), C22:6 omega-3] families are the most beneficial to improving reproduction in cows. Fatty Acids, Omega-3 144-151 PUFA Bos taurus 104-108 23184014-8 2013 Compared with placebo, omega-3 fatty acid supplementation led to greater endothelium-dependent vasodilatation with acetylcholine and substance P (p=0.0032 and p=0.056). Fatty Acids, Omega-3 23-41 tachykinin precursor 1 Homo sapiens 133-144 23184014-9 2013 Substance P caused a dose-dependent increase in plasma t-PA concentrations (p<0.0001) that was greater after omega-3 fatty acid supplementation compared with placebo (8.8+-2.3 IU ml(-1) vs 3.6+-1.1 IU ml(-1); p=0.029). Fatty Acids, Omega-3 112-130 tachykinin precursor 1 Homo sapiens 0-11 23184014-9 2013 Substance P caused a dose-dependent increase in plasma t-PA concentrations (p<0.0001) that was greater after omega-3 fatty acid supplementation compared with placebo (8.8+-2.3 IU ml(-1) vs 3.6+-1.1 IU ml(-1); p=0.029). Fatty Acids, Omega-3 112-130 plasminogen activator, tissue type Homo sapiens 55-59 23184014-11 2013 CONCLUSIONS: We have demonstrated for the first time that omega-3 fatty acids augment acute endothelial t-PA release and improve endothelial vasomotor function in cigarette smokers. Fatty Acids, Omega-3 58-77 plasminogen activator, tissue type Homo sapiens 104-108 23201820-9 2013 The proportion of very long-chain n-3 fatty acids in plasma were positively correlated with the pollutants: r=0.24 (PCB 28), r=0.33 (PCB 118), r=0.35 (PCB 138-180), r=0.29 (HCB), r=0.18 (beta-HCH), r=0.34 (chlordane compounds), r=0.34 (p,p"-DDE), p<=0.005. Fatty Acids, Omega-3 34-49 pyruvate carboxylase Homo sapiens 116-119 23213007-1 2013 SCOPE: We previously demonstrated that lifelong feeding of diets enriched in n-3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) significantly inhibits HER-2/neu-mediated mammary tumorigenesis in mice. Fatty Acids, Omega-3 77-92 erb-b2 receptor tyrosine kinase 2 Mus musculus 183-188 23213007-1 2013 SCOPE: We previously demonstrated that lifelong feeding of diets enriched in n-3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) significantly inhibits HER-2/neu-mediated mammary tumorigenesis in mice. Fatty Acids, Omega-3 77-92 erb-b2 receptor tyrosine kinase 2 Mus musculus 189-192 23313470-6 2013 Omega 3 fatty acids readily incorporated into hepatic phospholipids, decreased stearoyl-CoA desaturase 16, stearoyl-CoA desaturase, delta 6 desaturase, and delta 5 desaturase activities (calculated as product/substrate ratio) and decreased the "lipogenesis index", i.e., the proportion of fatty acids endogenously synthesized in the liver and not provided with the diet. Fatty Acids, Omega-3 0-19 stearoyl-CoA desaturase Rattus norvegicus 79-102 23313470-6 2013 Omega 3 fatty acids readily incorporated into hepatic phospholipids, decreased stearoyl-CoA desaturase 16, stearoyl-CoA desaturase, delta 6 desaturase, and delta 5 desaturase activities (calculated as product/substrate ratio) and decreased the "lipogenesis index", i.e., the proportion of fatty acids endogenously synthesized in the liver and not provided with the diet. Fatty Acids, Omega-3 0-19 stearoyl-CoA desaturase Rattus norvegicus 107-130 23313470-6 2013 Omega 3 fatty acids readily incorporated into hepatic phospholipids, decreased stearoyl-CoA desaturase 16, stearoyl-CoA desaturase, delta 6 desaturase, and delta 5 desaturase activities (calculated as product/substrate ratio) and decreased the "lipogenesis index", i.e., the proportion of fatty acids endogenously synthesized in the liver and not provided with the diet. Fatty Acids, Omega-3 0-19 fatty acid desaturase 2 Rattus norvegicus 132-150 23313470-6 2013 Omega 3 fatty acids readily incorporated into hepatic phospholipids, decreased stearoyl-CoA desaturase 16, stearoyl-CoA desaturase, delta 6 desaturase, and delta 5 desaturase activities (calculated as product/substrate ratio) and decreased the "lipogenesis index", i.e., the proportion of fatty acids endogenously synthesized in the liver and not provided with the diet. Fatty Acids, Omega-3 0-19 fatty acid desaturase 1 Rattus norvegicus 156-174 23265344-0 2013 Omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) trial. Fatty Acids, Omega-3 0-19 pumilio RNA binding family member 3 Homo sapiens 148-152 23066085-2 2013 Our previous studies have shown that the n-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) induces apoptosis in human prostate cancer cells by a syndecan-1 (SDC-1)-dependent mechanism. Fatty Acids, Omega-3 41-71 syndecan 1 Homo sapiens 153-163 23066085-2 2013 Our previous studies have shown that the n-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) induces apoptosis in human prostate cancer cells by a syndecan-1 (SDC-1)-dependent mechanism. Fatty Acids, Omega-3 41-71 syndecan 1 Homo sapiens 165-170 23089109-7 2013 Insulin resistance, C-reactive protein, tumour necrosis factor alpha, and interleukin 6 decreased across omega-3 PUFA tertiles among the Health 2000 survey participants. Fatty Acids, Omega-3 105-112 insulin Homo sapiens 0-7 23193970-0 2013 Inhibition of nuclear factor kappa B activation in early-stage chronic lymphocytic leukemia by omega-3 fatty acids. Fatty Acids, Omega-3 95-114 nuclear factor kappa B subunit 1 Homo sapiens 14-36 23193970-2 2013 We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFkappaB activation in lymphocytes of Rai Stage 0-1 CLL patients. Fatty Acids, Omega-3 24-43 nuclear factor kappa B subunit 1 Homo sapiens 76-84 23047296-1 2013 BACKGROUND: Intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is associated with a lower risk of atherosclerotic cardiovascular events, particularly acute myocardial infarction (AMI). Fatty Acids, Omega-3 33-64 pumilio RNA binding family member 3 Homo sapiens 70-74 23201820-9 2013 The proportion of very long-chain n-3 fatty acids in plasma were positively correlated with the pollutants: r=0.24 (PCB 28), r=0.33 (PCB 118), r=0.35 (PCB 138-180), r=0.29 (HCB), r=0.18 (beta-HCH), r=0.34 (chlordane compounds), r=0.34 (p,p"-DDE), p<=0.005. Fatty Acids, Omega-3 34-49 pyruvate carboxylase Homo sapiens 133-136 23201820-9 2013 The proportion of very long-chain n-3 fatty acids in plasma were positively correlated with the pollutants: r=0.24 (PCB 28), r=0.33 (PCB 118), r=0.35 (PCB 138-180), r=0.29 (HCB), r=0.18 (beta-HCH), r=0.34 (chlordane compounds), r=0.34 (p,p"-DDE), p<=0.005. Fatty Acids, Omega-3 34-49 pyruvate carboxylase Homo sapiens 133-136 24002405-10 2013 Supplementation with omega-3 fatty acids, alpha-lipoic acid and N-acetylcysteine is considered to have an anti-inflammatory and antioxidant effect and to improve dyslipidemia and insulin sensitivity in PCOS women. Fatty Acids, Omega-3 21-40 insulin Homo sapiens 179-186 23548422-9 2013 Inclusion in the treatment of patients with chronic heart failure of ischemic etiology and persistent AF omega-3 fatty acids provides reliable vasoprotective effect by suppressing the abnormal collagen formation on the dynamics of TIMP-1 (p<0.001) and improving the elastic properties of the arterial wall to the dynamics of high-speed data and indexed blood flow the arterial tree (p<0.001), with the exception of ankle-brachial indexes. Fatty Acids, Omega-3 105-124 TIMP metallopeptidase inhibitor 1 Homo sapiens 231-237 22683527-7 2013 However, the protective effect of omega3 fatty acids might be limited to APOE4 non-carriers. Fatty Acids, Omega-3 34-52 apolipoprotein E Homo sapiens 73-78 23885993-1 2013 OBJECTIVE: The omega-3 polyunsaturated fatty acid (n-3 PUFA) as well as lignan components of flaxseed (FLX) can have beneficial effects. Fatty Acids, Omega-3 15-49 pumilio RNA binding family member 3 Homo sapiens 55-59 31667003-0 2013 Relationship of Omega-3 Fatty Acids on C-Reactive Protein and Homocysteine in Haitian and African Americans with and without Type 2 Diabetes. Fatty Acids, Omega-3 16-35 C-reactive protein Homo sapiens 39-57 22504132-1 2013 BACKGROUND: Omega-3 fatty acid (omega-3 FA) lipid emulsion has been reported to inhibit nitric oxide (NO) production and alter inducible nitric oxide synthase (iNOS) protein expression in lipopolysaccharide (LPS)-stimulated murine macrophages. Fatty Acids, Omega-3 12-30 nitric oxide synthase 2, inducible Mus musculus 127-158 22504132-1 2013 BACKGROUND: Omega-3 fatty acid (omega-3 FA) lipid emulsion has been reported to inhibit nitric oxide (NO) production and alter inducible nitric oxide synthase (iNOS) protein expression in lipopolysaccharide (LPS)-stimulated murine macrophages. Fatty Acids, Omega-3 12-30 nitric oxide synthase 2, inducible Mus musculus 160-164 22504132-1 2013 BACKGROUND: Omega-3 fatty acid (omega-3 FA) lipid emulsion has been reported to inhibit nitric oxide (NO) production and alter inducible nitric oxide synthase (iNOS) protein expression in lipopolysaccharide (LPS)-stimulated murine macrophages. Fatty Acids, Omega-3 32-42 nitric oxide synthase 2, inducible Mus musculus 127-158 22504132-1 2013 BACKGROUND: Omega-3 fatty acid (omega-3 FA) lipid emulsion has been reported to inhibit nitric oxide (NO) production and alter inducible nitric oxide synthase (iNOS) protein expression in lipopolysaccharide (LPS)-stimulated murine macrophages. Fatty Acids, Omega-3 32-42 nitric oxide synthase 2, inducible Mus musculus 160-164 22504132-5 2013 In the present study, we hypothesized that omega-3 FA emulsion pretreatment would decrease the production of NO in LPS-stimulated macrophages and that this effect would occur through alterations in the cellular uptake of l-arginine and CAT-2 expression, in addition to iNOS expression. Fatty Acids, Omega-3 43-53 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 236-241 22504132-5 2013 In the present study, we hypothesized that omega-3 FA emulsion pretreatment would decrease the production of NO in LPS-stimulated macrophages and that this effect would occur through alterations in the cellular uptake of l-arginine and CAT-2 expression, in addition to iNOS expression. Fatty Acids, Omega-3 43-53 nitric oxide synthase 2, inducible Mus musculus 269-273 23563245-0 2013 Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer"s disease: the OmegAD study. Fatty Acids, Omega-3 71-87 transthyretin Homo sapiens 11-24 23563245-2 2013 N - 3 fatty acids (FA), docosahexaenoic (DHA), and eicosapentaenoic acid (EPA) may increase TTR transcription in rat hippocampus. Fatty Acids, Omega-3 0-17 transthyretin Rattus norvegicus 92-95 23563245-3 2013 We studied effects of n - 3 FA supplementation on TTR-levels in patients with AD. Fatty Acids, Omega-3 22-30 transthyretin Homo sapiens 50-53 23563245-12 2013 Repeated measures ANOVA indicated an increase in TTR over time (p = 0.04) in those receiving n - 3 FA for 12 months. Fatty Acids, Omega-3 93-101 transthyretin Homo sapiens 49-52 23563245-14 2013 Thus, n - 3 FA treatment appeared to increase plasma-TTR in patients with AD. Fatty Acids, Omega-3 6-14 transthyretin Homo sapiens 53-56 22903547-1 2013 In a recent study, we showed that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two common omega-3 fatty acids, can cause ROS accumulation and subsequently induce caspase-8-dependent apoptosis in human breast cancer cells (Kang et al. Fatty Acids, Omega-3 105-124 caspase 8 Homo sapiens 177-186 22504132-13 2013 iNOS and CAT-2 mRNA was significantly decreased with omega-3 FA pretreatment compared with omega-6 FA or media-only treatment (P < 0.05). Fatty Acids, Omega-3 53-63 nitric oxide synthase 2, inducible Mus musculus 0-4 22504132-13 2013 iNOS and CAT-2 mRNA was significantly decreased with omega-3 FA pretreatment compared with omega-6 FA or media-only treatment (P < 0.05). Fatty Acids, Omega-3 53-63 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 9-14 23184649-5 2013 Co-treatment of ethanol-binged slice cultures with docosahexaenoic acid (DHA), an omega-3 fatty acid known to suppress brain damage from other insults, prevents both the AQP4 elevations and the neurodamage. Fatty Acids, Omega-3 82-100 aquaporin 4 Rattus norvegicus 170-174 23372666-5 2013 The addition of Fe/Asc to Caco-2/15 cells induced OxS as demonstrated by the rise in malondialdehyde, depletion of n-3 polyunsaturated fatty acids, and alterations in the activity of endogenous antioxidants (SOD, GPx, G-Red). Fatty Acids, Omega-3 115-146 PYD and CARD domain containing Homo sapiens 19-22 23563024-1 2013 BACKGROUND: Our aim was to assess whether an early introduced n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation affects depression symptoms, anxiety and emotional state in patients with acute myocardial infarction (AMI) and no history of mental disorders. Fatty Acids, Omega-3 62-93 pumilio RNA binding family member 3 Homo sapiens 99-103 22806626-5 2012 Ces1/Es-x deficiency prevents the release of polyunsaturated fatty acids from triacylglycerol stores, leading to an up-regulation of sterol regulatory element binding protein 1c-mediated lipogenesis, which can be reversed with dietary omega-3 fatty acids. Fatty Acids, Omega-3 235-254 carboxylesterase 1G Mus musculus 0-4 23589776-2 2013 Authors sought to assess the association of prostate cancer risk with blood levels of omega-3 polyunsaturated fatty acids (n-3 PUFA) through a meta-analysis of human epidemiological studies in available online databases (July, 2012). Fatty Acids, Omega-3 86-121 pumilio RNA binding family member 3 Homo sapiens 127-131 23649389-1 2013 Docosahexaenoic acid (DHA), a predominant of n-3 polyunsaturated fatty acids (n-3 PUFA), has numerous beneficial physiological effects, including neuroprotection and cardiovascular protection. Fatty Acids, Omega-3 45-76 pumilio RNA binding family member 3 Homo sapiens 82-86 23497599-7 2012 RESULTS: Although EPA supplementation increased the level of plasma EPA and omega-3 fatty acids in both carriers of FABP2 and PPARalpha genes, these effects were more pronounced in Thr54 and Val162 carriers. Fatty Acids, Omega-3 76-95 fatty acid binding protein 2 Homo sapiens 116-121 23497599-7 2012 RESULTS: Although EPA supplementation increased the level of plasma EPA and omega-3 fatty acids in both carriers of FABP2 and PPARalpha genes, these effects were more pronounced in Thr54 and Val162 carriers. Fatty Acids, Omega-3 76-95 peroxisome proliferator activated receptor alpha Homo sapiens 126-135 23561883-3 2012 Conversely, n3 fatty acids are generally antiinflammatory and promote insulin sensitivity, in part via peroxisome proliferator-activated receptor gamma. Fatty Acids, Omega-3 12-26 insulin Sus scrofa 70-77 23561883-3 2012 Conversely, n3 fatty acids are generally antiinflammatory and promote insulin sensitivity, in part via peroxisome proliferator-activated receptor gamma. Fatty Acids, Omega-3 12-26 peroxisome proliferator activated receptor gamma Sus scrofa 103-151 23561883-7 2012 In addition, n3 fatty acids attenuated the increase in inflammatory adipose tissue CD16(-)CD14(+) macrophages induced by high palm oil. Fatty Acids, Omega-3 13-27 CD14 Sus scrofa 90-94 23561883-11 2012 Therefore, in obese Ossabaw swine, n3 fatty acids partially attenuate insulin resistance but only marginally change inflammatory status and macrophage phenotype in adipose tissue. Fatty Acids, Omega-3 35-49 insulin Sus scrofa 70-77 22770766-4 2013 Omega-3 polyunsaturated fatty acids (n-3 PUFA) are anti-inflammatory in many non-neural tissues; their role in neuroinflammation is less studied. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 23338919-0 2013 Comment on: efficacy of omega-3 fatty acid supplementation on serum levels of tumour necrosis factor-alpha, C-reactive protein and interleukin-2 in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 24-42 C-reactive protein Homo sapiens 108-126 23338919-0 2013 Comment on: efficacy of omega-3 fatty acid supplementation on serum levels of tumour necrosis factor-alpha, C-reactive protein and interleukin-2 in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 24-42 interleukin 2 Homo sapiens 131-144 24688934-9 2012 RESULTS: Omega-3 fatty acids significantly decreased TC/HDL-C and LDL-C/HDL-C ratios (P = 0.009 for both) and significantly increased serum PON1 activity (P = 0.048) compared with placebo. Fatty Acids, Omega-3 9-28 paraoxonase 1 Homo sapiens 140-144 24688934-11 2012 Reduction in TC/HDL-C, LDL-C/HDL-C and TG/HDL-C ratios and increase in serum PON1 activity were also significant in omega-3 fatty acids group at the end of the study compared with baseline values (P <0.001, P < 0.001, P = 0.004, and P = 0.001, respectively). Fatty Acids, Omega-3 116-135 paraoxonase 1 Homo sapiens 77-81 23042820-2 2012 Because of their anti-inflammatory properties we hypothesized that n-3 fatty acids, in contrast to saturated fatty acids, would lower macrophages and arterial EL and inflammatory markers. Fatty Acids, Omega-3 67-82 lipase, endothelial Mus musculus 159-161 23042820-11 2012 CONCLUSIONS: n-3 fatty acids, in contrast to saturated fatty acids, decrease EL in parallel with modulating pro- and anti-inflammatory markers, and these effects on EL link to PPARgamma. Fatty Acids, Omega-3 13-28 peroxisome proliferator activated receptor gamma Mus musculus 176-185 22806626-5 2012 Ces1/Es-x deficiency prevents the release of polyunsaturated fatty acids from triacylglycerol stores, leading to an up-regulation of sterol regulatory element binding protein 1c-mediated lipogenesis, which can be reversed with dietary omega-3 fatty acids. Fatty Acids, Omega-3 235-254 sterol regulatory element binding transcription factor 1 Mus musculus 133-176 23308056-0 2012 Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice. Fatty Acids, Omega-3 11-42 FAT atypical cadherin 1 Mus musculus 100-105 23308056-0 2012 Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice. Fatty Acids, Omega-3 11-42 Kirsten rat sarcoma viral oncogene homolog Mus musculus 121-125 23308056-0 2012 Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice. Fatty Acids, Omega-3 11-42 interferon regulatory factor 9 Mus musculus 106-109 23149286-4 2012 This review focuses on 2 PPD risk factors of emerging interest: serotonin transporter (5-HTT) genotype and omega-3 polyunsaturated fatty acid (n-3 PUFA) status. Fatty Acids, Omega-3 107-141 pumilio RNA binding family member 3 Homo sapiens 147-151 22981383-0 2012 Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Fatty Acids, Omega-3 25-56 FAT atypical cadherin 1 Mus musculus 60-65 22981383-12 2012 These data suggest that n-3 PUFAs ameliorate diet-induced hyperlipidemia and fatty liver through induction of CYP7A1 expression and activation of cholesterol catabolism to bile acid. Fatty Acids, Omega-3 24-33 cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus 110-116 23312051-8 2012 CONCLUSION: Supplementation with n-3 PUFA resulted in lower levels of FPG, plasma lipids, MMPs, and inflammatory parameters and in a better increase of M value compared to placebo, both in the fasting state and after an OFL. Fatty Acids, Omega-3 33-41 matrix metallopeptidase 2 Homo sapiens 90-94 23285432-1 2012 OBJECTIVES: This study intended to assess the effects of the antioxidants; Alpha Lipoic Acid (ALA), omega 3 fatty acids and vitamin E on the parameters of insulin sensitivity, oxidative stress, lipid metabolism and glycaemic control in patients of type 2 diabetes mellitus. Fatty Acids, Omega-3 100-119 insulin Homo sapiens 155-162 23285432-10 2012 CONCLUSION: ALA, omega 3 fatty acids and vitamin E showed the improvement in insulin sensitivity. Fatty Acids, Omega-3 17-36 insulin Homo sapiens 77-84 23037902-1 2012 PURPOSE OF REVIEW: Evidence from various research paradigms supports the cardiovascular benefits of a high intake of n-3 polyunsaturated fatty acids (PUFAs), especially the long-chain, marine-derived n-3 PUFA, eicosapentaenoic acids and docosahexaenoic acids. Fatty Acids, Omega-3 117-148 pumilio RNA binding family member 3 Homo sapiens 150-154 22939867-2 2012 Substantial studies showed n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit a powerful anti-inflammatory effects in and ex vivo through reducing the production of IL-1 and TNF-alpha and increasing the expression of IL-4, IL-10, TGF-beta and IGF-1 in OA. Fatty Acids, Omega-3 27-58 interleukin 1 alpha Homo sapiens 166-170 22939867-2 2012 Substantial studies showed n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit a powerful anti-inflammatory effects in and ex vivo through reducing the production of IL-1 and TNF-alpha and increasing the expression of IL-4, IL-10, TGF-beta and IGF-1 in OA. Fatty Acids, Omega-3 27-58 tumor necrosis factor Homo sapiens 175-184 22939867-2 2012 Substantial studies showed n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit a powerful anti-inflammatory effects in and ex vivo through reducing the production of IL-1 and TNF-alpha and increasing the expression of IL-4, IL-10, TGF-beta and IGF-1 in OA. Fatty Acids, Omega-3 27-58 interleukin 4 Homo sapiens 218-222 22939867-2 2012 Substantial studies showed n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit a powerful anti-inflammatory effects in and ex vivo through reducing the production of IL-1 and TNF-alpha and increasing the expression of IL-4, IL-10, TGF-beta and IGF-1 in OA. Fatty Acids, Omega-3 27-58 interleukin 10 Homo sapiens 224-229 22939867-2 2012 Substantial studies showed n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit a powerful anti-inflammatory effects in and ex vivo through reducing the production of IL-1 and TNF-alpha and increasing the expression of IL-4, IL-10, TGF-beta and IGF-1 in OA. Fatty Acids, Omega-3 27-58 transforming growth factor beta 1 Homo sapiens 231-239 22939867-2 2012 Substantial studies showed n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibit a powerful anti-inflammatory effects in and ex vivo through reducing the production of IL-1 and TNF-alpha and increasing the expression of IL-4, IL-10, TGF-beta and IGF-1 in OA. Fatty Acids, Omega-3 27-58 insulin like growth factor 1 Homo sapiens 244-249 22217518-0 2012 Down-regulation of vascular HMGB1 and RAGE expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts. Fatty Acids, Omega-3 57-88 high mobility group box 1 Rattus norvegicus 28-33 22995157-0 2012 Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 103-138 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 27-45 22995157-1 2012 In vitro cytochrome P4501A1 (CYP1A1) metabolizes omega-3 polyunsaturated fatty acids (n-3 PUFAs); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), primarily to 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP), respectively. Fatty Acids, Omega-3 49-84 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 9-27 22995157-1 2012 In vitro cytochrome P4501A1 (CYP1A1) metabolizes omega-3 polyunsaturated fatty acids (n-3 PUFAs); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), primarily to 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP), respectively. Fatty Acids, Omega-3 49-84 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 29-35 22995157-1 2012 In vitro cytochrome P4501A1 (CYP1A1) metabolizes omega-3 polyunsaturated fatty acids (n-3 PUFAs); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), primarily to 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP), respectively. Fatty Acids, Omega-3 86-95 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 9-27 22995157-1 2012 In vitro cytochrome P4501A1 (CYP1A1) metabolizes omega-3 polyunsaturated fatty acids (n-3 PUFAs); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), primarily to 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP), respectively. Fatty Acids, Omega-3 86-95 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 29-35 28496771-1 2012 Many physicians recommend the use of fish oil or omega-3 polyunsaturated fatty acids (n-3 PUFA) in atrial fibrillation (AF) patients. Fatty Acids, Omega-3 49-84 pumilio RNA binding family member 3 Homo sapiens 90-94 22314192-5 2012 Various treatments successful at improving insulin response (thiazolidinediones (TZDs), n-3 polyunsaturated fatty acid (PUFA) supplementation) also stimulate adiponectin production. Fatty Acids, Omega-3 88-118 insulin Homo sapiens 43-50 22314192-5 2012 Various treatments successful at improving insulin response (thiazolidinediones (TZDs), n-3 polyunsaturated fatty acid (PUFA) supplementation) also stimulate adiponectin production. Fatty Acids, Omega-3 88-118 adiponectin, C1Q and collagen domain containing Homo sapiens 158-169 23529993-9 2012 Omega-3 fatty acids significantly decreased glucose (by 11.4%, p < 0.001), insulin (by 8.4%, p < 0.05), and homeostatic model assessment for insulin resistance (by 21.8%, p < 0.001) compared with placebo. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 78-85 23529993-9 2012 Omega-3 fatty acids significantly decreased glucose (by 11.4%, p < 0.001), insulin (by 8.4%, p < 0.05), and homeostatic model assessment for insulin resistance (by 21.8%, p < 0.001) compared with placebo. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 147-154 23529993-11 2012 CONCLUSION: Omega-3 fatty acids improved insulin sensitivity in PCOS patients. Fatty Acids, Omega-3 12-31 insulin Homo sapiens 41-48 22217518-0 2012 Down-regulation of vascular HMGB1 and RAGE expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts. Fatty Acids, Omega-3 57-88 advanced glycosylation end product-specific receptor Rattus norvegicus 38-42 23035806-1 2012 The purpose of this review is to outline the current evidence regarding the effects of micronutrient and omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on the cognition, learning, and behavior of children and adolescents living in developed societies. Fatty Acids, Omega-3 105-139 pumilio RNA binding family member 3 Homo sapiens 145-149 22976420-10 2012 Immunomodulating diets (IMDs) containing supplemental arginine and omega-3 fatty acids have been demonstrated to restore the Th1/Th2 balance after surgical trauma and to reduce the risk of infectious complications. Fatty Acids, Omega-3 67-86 negative elongation factor complex member C/D Homo sapiens 125-128 22226487-8 2012 Aged omega-3 fatty acid deficient animals displayed increased hypothalamic cytosolic phospholipase A(2) (cPLA(2)), cyclooxygenase (COX)-2, and prostaglandin E (PGE) synthase messenger (m)RNA expression, compared with animals that received omega-3 fatty acids. Fatty Acids, Omega-3 5-23 phospholipase A2 group IVA Rattus norvegicus 75-112 22226487-8 2012 Aged omega-3 fatty acid deficient animals displayed increased hypothalamic cytosolic phospholipase A(2) (cPLA(2)), cyclooxygenase (COX)-2, and prostaglandin E (PGE) synthase messenger (m)RNA expression, compared with animals that received omega-3 fatty acids. Fatty Acids, Omega-3 5-23 cytochrome c oxidase II, mitochondrial Rattus norvegicus 115-137 22750665-8 2012 These preclinical data support the hypothesis that low n-3 fatty acid status exacerbates RSP-induced hepatic steatosis by augmenting SCD1 expression and activity. Fatty Acids, Omega-3 55-69 stearoyl-CoA desaturase Rattus norvegicus 133-137 22945403-1 2012 BACKGROUND AND OBJECTIVE: Relative deficiency of dietary omega 3 polyunsaturated fatty acids (n-3 PUFA) has been implicated in the rising allergy prevalence in Westernized countries. Fatty Acids, Omega-3 57-92 pumilio RNA binding family member 3 Homo sapiens 98-102 22851761-1 2012 The potential for dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) to improve reproductive efficiency in cattle has received much interest. Fatty Acids, Omega-3 47-78 PUFA Bos taurus 84-88 22913633-7 2012 Hence, omega-3 fatty acids, which are also known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines interleukin (IL)-4 and IL-10 as well as acetylcholine in the hippocampus, may be protective. Fatty Acids, Omega-3 7-26 interleukin 10 Homo sapiens 166-171 22978374-6 2012 RESULTS: Among the altered proteins, clusterin, paraoxonase, and apoAI were found to increase, while fibronectin, alpha-1-antitrypsin, complement C1r subcomponent and complement factor H decreased after diet supplementation with omega-3 PUFAs. Fatty Acids, Omega-3 229-236 serpin family A member 1 Homo sapiens 114-133 22564824-5 2012 Studies in mice and human subjects indicate that the apoE epsilon3 but not the apoE epsilon4 genotype may significantly benefit from dietary flavonoids (e.g. quercetin) and n-3 fatty acids. Fatty Acids, Omega-3 173-188 apolipoprotein E Homo sapiens 53-57 23023905-0 2012 Efficacy of omega-3 fatty acid supplementation on serum levels of tumour necrosis factor-alpha, C-reactive protein and interleukin-2 in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 12-30 C-reactive protein Homo sapiens 96-114 23023905-0 2012 Efficacy of omega-3 fatty acid supplementation on serum levels of tumour necrosis factor-alpha, C-reactive protein and interleukin-2 in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 12-30 interleukin 2 Homo sapiens 119-132 23023905-2 2012 This study aimed to determine the effects of omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin (IL)-2 and tumour necrosis factor-alpha (TNF-alpha) in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 45-63 C-reactive protein Homo sapiens 103-121 23023905-2 2012 This study aimed to determine the effects of omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin (IL)-2 and tumour necrosis factor-alpha (TNF-alpha) in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 45-63 C-reactive protein Homo sapiens 123-126 23023905-2 2012 This study aimed to determine the effects of omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin (IL)-2 and tumour necrosis factor-alpha (TNF-alpha) in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 45-63 interleukin 2 Homo sapiens 129-147 23023905-2 2012 This study aimed to determine the effects of omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin (IL)-2 and tumour necrosis factor-alpha (TNF-alpha) in type 2 diabetes mellitus patients. Fatty Acids, Omega-3 45-63 tumor necrosis factor Homo sapiens 182-191 23023905-9 2012 CONCLUSION: Short-term omega-3 fatty acid supplementation (3 g/day for eight weeks) can decrease the serum levels of TNF-alpha and IL-2 in diabetic patients, with no change in CRP levels. Fatty Acids, Omega-3 23-41 tumor necrosis factor Homo sapiens 117-126 23023905-9 2012 CONCLUSION: Short-term omega-3 fatty acid supplementation (3 g/day for eight weeks) can decrease the serum levels of TNF-alpha and IL-2 in diabetic patients, with no change in CRP levels. Fatty Acids, Omega-3 23-41 interleukin 2 Homo sapiens 131-135 22579981-10 2012 Our findings for the first time suggest that omega 3 fatty acid supplementation to a micronutrient-imbalanced diet, during pregnancy and lactation protects the levels of BDNF and NGF. Fatty Acids, Omega-3 45-63 brain-derived neurotrophic factor Rattus norvegicus 170-174 22564824-8 2012 The present review aims at evaluation of current data available on interactions between apoE polymorphism and dietary responsiveness to flavonoids, fat soluble vitamins and n-3 fatty acids. Fatty Acids, Omega-3 173-188 apolipoprotein E Homo sapiens 88-92 21889886-7 2012 Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was associated with lower TNFalpha concentrations [adjusted odds ratio (OR)=0.46; P=.049]. Fatty Acids, Omega-3 43-61 tumor necrosis factor Homo sapiens 89-97 22934026-0 2012 Omega 3 fatty acid inhibition of inflammatory cytokine-mediated Connexin43 regulation in the heart. Fatty Acids, Omega-3 0-18 gap junction protein alpha 1 Canis lupus familiaris 64-74 22934026-2 2012 Omega 3 Fatty acids exhibit antiarrhythmic properties and impact IL-1beta signaling. Fatty Acids, Omega-3 0-19 interleukin 1 beta Canis lupus familiaris 65-73 22934026-3 2012 We hypothesize that Omega-3 fatty acids prevent arrhythmias in part, by inhibiting IL-1beta signaling thus maintaining functional Cx43 channels. Fatty Acids, Omega-3 20-39 interleukin 1 beta Canis lupus familiaris 83-91 22934026-3 2012 We hypothesize that Omega-3 fatty acids prevent arrhythmias in part, by inhibiting IL-1beta signaling thus maintaining functional Cx43 channels. Fatty Acids, Omega-3 20-39 gap junction protein alpha 1 Canis lupus familiaris 130-134 22934026-7 2012 In addition we used a murine model of MI for 24 h to determine the impact of an Omega-3 fatty acid enriched diet on Cx43 levels/localization post MI. Fatty Acids, Omega-3 80-98 gap junction protein, alpha 1 Mus musculus 116-120 22934026-12 2012 Additionally we found that a diet enriched in Omega-3 Fatty acids inhibited lateralization of Cx43 in the post-MI murine heart as well as limited activation of fibroblasts which would lead to decreased fibrosis overall. Fatty Acids, Omega-3 46-65 gap junction protein, alpha 1 Mus musculus 94-98 22934026-13 2012 CONCLUSIONS: Omega 3 Fatty acid treatment inhibited IL-1beta-stimulated loss of Cx43 protein, and more importantly, inhibited loss of Cx43 function by inhibiting translocation of NFkappabeta. Fatty Acids, Omega-3 13-31 interleukin 1 beta Canis lupus familiaris 52-60 22934026-13 2012 CONCLUSIONS: Omega 3 Fatty acid treatment inhibited IL-1beta-stimulated loss of Cx43 protein, and more importantly, inhibited loss of Cx43 function by inhibiting translocation of NFkappabeta. Fatty Acids, Omega-3 13-31 gap junction protein alpha 1 Canis lupus familiaris 80-84 22934026-13 2012 CONCLUSIONS: Omega 3 Fatty acid treatment inhibited IL-1beta-stimulated loss of Cx43 protein, and more importantly, inhibited loss of Cx43 function by inhibiting translocation of NFkappabeta. Fatty Acids, Omega-3 13-31 gap junction protein alpha 1 Canis lupus familiaris 134-138 22934026-14 2012 In the intact heart a diet enriched in Omega 3 Fatty Acids limited loss of Cx43 at the intercalated disk in the heart following MI. Fatty Acids, Omega-3 39-58 gap junction protein alpha 1 Canis lupus familiaris 75-79 22934026-15 2012 These data suggest that one of cardio-protective mechanisms by which Omega 3 Fatty acids work includes prevention of the pro-arrhythmic loss of Cx43 post MI and the attenuation of cardiac fibrosis after injury. Fatty Acids, Omega-3 69-88 gap junction protein alpha 1 Canis lupus familiaris 144-148 22668831-12 2012 CONCLUSIONS: The data suggest that TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel of adipocytes that negatively regulates adiponectin and through which omega-3 fatty acids enhance the anti-inflammatory adipokine, adiponectin. Fatty Acids, Omega-3 181-200 transient receptor potential cation channel subfamily C member 1 Homo sapiens 35-40 22668831-12 2012 CONCLUSIONS: The data suggest that TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel of adipocytes that negatively regulates adiponectin and through which omega-3 fatty acids enhance the anti-inflammatory adipokine, adiponectin. Fatty Acids, Omega-3 181-200 transient receptor potential cation channel subfamily C member 5 Homo sapiens 45-50 22668831-12 2012 CONCLUSIONS: The data suggest that TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel of adipocytes that negatively regulates adiponectin and through which omega-3 fatty acids enhance the anti-inflammatory adipokine, adiponectin. Fatty Acids, Omega-3 181-200 adiponectin, C1Q and collagen domain containing Homo sapiens 151-162 22668831-12 2012 CONCLUSIONS: The data suggest that TRPC1 and TRPC5 contribute a constitutively active heteromultimeric channel of adipocytes that negatively regulates adiponectin and through which omega-3 fatty acids enhance the anti-inflammatory adipokine, adiponectin. Fatty Acids, Omega-3 181-200 adiponectin, C1Q and collagen domain containing Homo sapiens 242-253 22901557-0 2012 Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. Fatty Acids, Omega-3 0-18 alpha 2-HS glycoprotein Homo sapiens 73-81 22901557-2 2012 We hypothesized that omega-3 fatty acid (FA), which has cardioprotective properties, modifies vitamin D status, fetuin-A, and FGF-23 levels in dialysis patients. Fatty Acids, Omega-3 21-39 alpha 2-HS glycoprotein Homo sapiens 112-120 22901557-2 2012 We hypothesized that omega-3 fatty acid (FA), which has cardioprotective properties, modifies vitamin D status, fetuin-A, and FGF-23 levels in dialysis patients. Fatty Acids, Omega-3 21-39 fibroblast growth factor 23 Homo sapiens 126-132 22901557-7 2012 After 6 months, the levels of 1,25-dihydroxyvitamin D and fetuin-A were significantly increased in the group taking the omega-3 FA supplement compared with baseline. Fatty Acids, Omega-3 120-130 alpha 2-HS glycoprotein Homo sapiens 58-66 22901557-10 2012 Regarding vascular calcification and cardiovascular disease, omega-3 FA supplementation may have a clinical benefit caused by activating vitamin D, increasing fetuin-A levels, and modifying erythrocyte membrane FA contents in dialysis patients. Fatty Acids, Omega-3 61-71 alpha 2-HS glycoprotein Homo sapiens 159-167 22473784-10 2012 Results showed that dietary n-3 fatty acid deficiency elevates the vulnerability to metabolic dysfunction and impaired cognitive functions by modulating insulin receptor signalling and synaptic plasticity. Fatty Acids, Omega-3 28-42 insulin receptor Rattus norvegicus 153-169 22542696-2 2012 Recent pharmacological studies have suggested several molecular targets for the anti-inflammatory effects of omega-3 fatty acids, namely, nuclear receptor PPARgamma and the G protein-coupled receptor GPR120. Fatty Acids, Omega-3 109-128 peroxisome proliferator activated receptor gamma Homo sapiens 155-164 22542696-2 2012 Recent pharmacological studies have suggested several molecular targets for the anti-inflammatory effects of omega-3 fatty acids, namely, nuclear receptor PPARgamma and the G protein-coupled receptor GPR120. Fatty Acids, Omega-3 109-128 free fatty acid receptor 4 Homo sapiens 200-206 22738017-0 2012 Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat. Fatty Acids, Omega-3 132-147 peroxisome proliferator activated receptor alpha Rattus norvegicus 33-37 22113248-0 2012 Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. Fatty Acids, Omega-3 21-52 C-reactive protein Homo sapiens 58-76 22436699-6 2012 Chia seed supplementation for 24 wk attenuated most structural and functional modifications induced by age or H diet, including increased whole body lean mass and lipid redistribution from the abdominal area, and normalized the chronic low-grade inflammation induced by H diet feeding; these effects may be mediated by increased metabolism of anti-inflammatory n-3 fatty acids from chia seed. Fatty Acids, Omega-3 361-376 chitinase, acidic Rattus norvegicus 0-4 22591892-2 2012 The use of very long chain n-3 polyunsaturated fatty acids (VLC n3 PUFA) could potentially benefit MS by reducing risk factors. Fatty Acids, Omega-3 27-58 pumilio RNA binding family member 3 Homo sapiens 67-71 22591898-3 2012 METHODS: Electronic databases were systematically searched for RCT of fish oil or omega-3 PUFA therapy in both active and inactive ulcerative colitis or Crohn"s disease, without limitation on either the length of therapy or the form it was given, including nutritional supplements and enteral formula diets. Fatty Acids, Omega-3 82-89 pumilio RNA binding family member 3 Homo sapiens 90-94 22591901-8 2012 Greater consistency was observed in studies that involved the FADS1 and FADS2 locus in the determination of n-3 fatty acid concentrations in biological samples. Fatty Acids, Omega-3 108-122 fatty acid desaturase 1 Homo sapiens 62-67 22591901-8 2012 Greater consistency was observed in studies that involved the FADS1 and FADS2 locus in the determination of n-3 fatty acid concentrations in biological samples. Fatty Acids, Omega-3 108-122 fatty acid desaturase 2 Homo sapiens 72-77 22591904-1 2012 The aims of the present study were to review the validity of dietary methods used to measure the usual long chain (LC) omega-3 polyunsaturated fatty acid (n-3 PUFA) intake of a population and to assess the usefulness of different biomarkers of n-3 PUFA in healthy humans. Fatty Acids, Omega-3 119-153 pumilio RNA binding family member 3 Homo sapiens 159-163 21918821-1 2012 n-3 Polyunsaturated fatty acids (n-3 PUFA) are important for human health. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 37-41 22473784-0 2012 "Metabolic syndrome" in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. Fatty Acids, Omega-3 49-67 insulin receptor Rattus norvegicus 96-112 22227286-0 2012 n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice. Fatty Acids, Omega-3 0-15 tumor necrosis factor (ligand) superfamily, member 13b Mus musculus 78-102 22227286-0 2012 n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice. Fatty Acids, Omega-3 0-15 tumor necrosis factor (ligand) superfamily, member 13b Mus musculus 104-108 22227286-3 2012 METHODS: B-cell activating factor transgenic mice were fed for 12 weeks with either n-3 polyunsaturated fatty acids-enriched or control diet and we tested the effect of this dietary supplementation on hippocampal inflammation, progenitor cell proliferation and neurogenesis-dependent and neurogenesis-independent long-term potentiation. Fatty Acids, Omega-3 84-115 tumor necrosis factor (ligand) superfamily, member 13b Mus musculus 9-33 22227286-5 2012 Furthermore, B-cell activating factor transgenic mice fed with n-3 polyunsaturated fatty acids-enriched diet displayed normal long-term potentiation at the medial perforant pathway/dentate gyrus connections. Fatty Acids, Omega-3 63-94 tumor necrosis factor (ligand) superfamily, member 13b Mus musculus 13-37 22227286-6 2012 CONCLUSIONS: The results indicate that n-3 fatty acids prevent neuroinflammation and deficits of hippocampal plasticity in B-cell activating factor transgenic mice and suggest that increased n-3 fatty acids intake might represent a potential therapeutic option to prevent neuropsychiatric symptoms associated with autoimmune diseases. Fatty Acids, Omega-3 39-54 tumor necrosis factor (ligand) superfamily, member 13b Mus musculus 123-147 22227286-6 2012 CONCLUSIONS: The results indicate that n-3 fatty acids prevent neuroinflammation and deficits of hippocampal plasticity in B-cell activating factor transgenic mice and suggest that increased n-3 fatty acids intake might represent a potential therapeutic option to prevent neuropsychiatric symptoms associated with autoimmune diseases. Fatty Acids, Omega-3 191-206 tumor necrosis factor (ligand) superfamily, member 13b Mus musculus 123-147 22072108-1 2012 Dietary deficiency of omega-3 fatty acids (omega-3 DEF) produces hypertension in later life. Fatty Acids, Omega-3 22-41 UTP25 small subunit processome component Rattus norvegicus 51-54 22569435-0 2012 Effect of treatment with omega-3 fatty acids on C-reactive protein and tumor necrosis factor-alfa in hemodialysis patients. Fatty Acids, Omega-3 25-44 C-reactive protein Homo sapiens 48-66 22569435-3 2012 The aim of this study is to review the alterations in serum levels of TNF-alpha, CRP and other parameters caused by omega-3 supplementation in dialysis patients. Fatty Acids, Omega-3 116-123 tumor necrosis factor Homo sapiens 70-79 22569435-3 2012 The aim of this study is to review the alterations in serum levels of TNF-alpha, CRP and other parameters caused by omega-3 supplementation in dialysis patients. Fatty Acids, Omega-3 116-123 C-reactive protein Homo sapiens 81-84 22569435-9 2012 However, the use of omega-3 decreased the serum levels of TNF-alpha significantly. Fatty Acids, Omega-3 20-27 tumor necrosis factor Homo sapiens 58-67 22569435-10 2012 We conclude that the use of 3 g of omega-3 per day caused significant decrease in serum levels of TNF-alpha in the dialysis population, and its use is recommended in such patients. Fatty Acids, Omega-3 35-42 tumor necrosis factor Homo sapiens 98-107 22648845-1 2012 OBJECTIVE: To investigate the effects of n-3 polyunsaturated fatty acids(n-3PUFA) on human colorectal cancer cell line HT-29 and associated mechanism. Fatty Acids, Omega-3 41-72 pumilio RNA binding family member 3 Homo sapiens 76-80 22250985-0 2012 n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation. Fatty Acids, Omega-3 0-31 CD4 antigen Mus musculus 114-117 22458582-5 2012 Treatment of clinical LPL deficiency is by ultra-low-fat diet along with the use of fibrates, omega-3 fatty acids, niacin, statins and insulin-sensitizing therapies, depending on the extent of residual LPL activity. Fatty Acids, Omega-3 94-113 lipoprotein lipase Homo sapiens 22-25 22072108-1 2012 Dietary deficiency of omega-3 fatty acids (omega-3 DEF) produces hypertension in later life. Fatty Acids, Omega-3 22-29 UTP25 small subunit processome component Rattus norvegicus 51-54 24250476-11 2012 Long-term pretreatment with omega-3 fatty acids also decreased Bax protein expression (p < 0.05) with no effect on the expression of Bcl-2 protein. Fatty Acids, Omega-3 28-47 BCL2 associated X, apoptosis regulator Rattus norvegicus 63-66 21897424-0 2012 Significant inverse association of marine n-3 fatty acids with plasma fibrinogen levels in Japanese in Japan but not in whites or Japanese Americans. Fatty Acids, Omega-3 42-57 fibrinogen beta chain Homo sapiens 70-80 22316559-10 2012 Other mechanisms of the anti-inflammatory actions of omega-3 FAs involve the peroxisome proliferator-activated receptor-gamma, omega-3 FA incorporation into the cell membrane, and inhibition of ion currents. Fatty Acids, Omega-3 53-64 peroxisome proliferator activated receptor gamma Homo sapiens 77-134 21940900-2 2012 Recent evidence suggests that the anti-inflammatory/chemoprotective properties of fish oil (FO)-derived n-3 polyunsaturated fatty acids (PUFAs) may be partly mediated by PPARdelta. Fatty Acids, Omega-3 104-135 peroxisome proliferator activator receptor delta Mus musculus 170-179 22147666-0 2012 Insulin receptor substrate-2 gene variants in subjects with metabolic syndrome: association with plasma monounsaturated and n-3 polyunsaturated fatty acid levels and insulin resistance. Fatty Acids, Omega-3 124-154 insulin receptor substrate 2 Homo sapiens 0-28 22153696-7 2012 RESULTS: Omega-3 fatty acids therapy decreased triglycerides by 21% and triglycerides/HDL cholesterol and improved flow-mediated dilation (P<0.01), however, did not significantly change insulin, plasma adiponectin levels, and insulin sensitivity (determined by QUICKI) relative to baseline measurements. Fatty Acids, Omega-3 9-28 adiponectin, C1Q and collagen domain containing Homo sapiens 205-216 22153696-7 2012 RESULTS: Omega-3 fatty acids therapy decreased triglycerides by 21% and triglycerides/HDL cholesterol and improved flow-mediated dilation (P<0.01), however, did not significantly change insulin, plasma adiponectin levels, and insulin sensitivity (determined by QUICKI) relative to baseline measurements. Fatty Acids, Omega-3 9-28 insulin Homo sapiens 229-236 21922187-0 2012 Omega-3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-alpha), disease activity and response criteria. Fatty Acids, Omega-3 0-19 interleukin 1 alpha Homo sapiens 75-79 21922187-0 2012 Omega-3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-alpha), disease activity and response criteria. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 84-93 21922187-1 2012 This study aims to demonstrate the effect of omega-3 fatty acids (omega-3 FAs) supplements on the clinical manifestations, laboratory investigations, disease activity, functional capacity, response criteria as well as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) levels in juvenile idiopathic arthritis (JIA) patients. Fatty Acids, Omega-3 45-64 tumor necrosis factor Homo sapiens 272-281 22045025-10 2012 Our results suggest that consumption of high omega-3 diet slows down prostate tumorigenesis by lowering estradiol, testosterone and AR levels, promoting apoptosis and suppressing cell proliferation in C3(1)Tag mice. Fatty Acids, Omega-3 45-52 androgen receptor Mus musculus 132-134 23017309-0 2012 Effects of omega-3 fatty acids supplementation on serum adiponectin levels and some metabolic risk factors in women with polycystic ovary syndrome. Fatty Acids, Omega-3 11-30 adiponectin, C1Q and collagen domain containing Homo sapiens 56-67 23017309-2 2012 The objectives of this study were to investigate the effects of omega-3 fatty acids on serum adiponectin levels and some metabolic risk factors in PCOS patients. Fatty Acids, Omega-3 64-83 adiponectin, C1Q and collagen domain containing Homo sapiens 93-104 23017309-7 2012 Omega-3 fatty acids significantly increased serum levels of adiponectin (p=0.003) and decreased glucose (p<0.001), insulin (p=0.002), homeostatic model assessment for insulin resistance (p<0.001), total cholesterol (p=0.002) and low-density lipoprotein cholesterol (p=0.003) compared with placebo. Fatty Acids, Omega-3 0-19 adiponectin, C1Q and collagen domain containing Homo sapiens 60-71 23017309-7 2012 Omega-3 fatty acids significantly increased serum levels of adiponectin (p=0.003) and decreased glucose (p<0.001), insulin (p=0.002), homeostatic model assessment for insulin resistance (p<0.001), total cholesterol (p=0.002) and low-density lipoprotein cholesterol (p=0.003) compared with placebo. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 118-125 23017309-7 2012 Omega-3 fatty acids significantly increased serum levels of adiponectin (p=0.003) and decreased glucose (p<0.001), insulin (p=0.002), homeostatic model assessment for insulin resistance (p<0.001), total cholesterol (p=0.002) and low-density lipoprotein cholesterol (p=0.003) compared with placebo. Fatty Acids, Omega-3 0-19 insulin Homo sapiens 170-177 23017309-10 2012 CONCLUSION: Omega-3 fatty acids had some beneficial effects on serum adiponectin levels, insulin resistance and lipid profile in PCOS patients and may contribute to the improvement of metabolic complications in these patients. Fatty Acids, Omega-3 12-31 adiponectin, C1Q and collagen domain containing Homo sapiens 69-80 23017309-10 2012 CONCLUSION: Omega-3 fatty acids had some beneficial effects on serum adiponectin levels, insulin resistance and lipid profile in PCOS patients and may contribute to the improvement of metabolic complications in these patients. Fatty Acids, Omega-3 12-31 insulin Homo sapiens 89-96 21880016-0 2012 Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 142-173 nuclear factor, erythroid derived 2, like 2 Mus musculus 37-41 23056476-1 2012 Studies in rodents indicate that diets deficient in omega-3 polyunsaturated fatty acids (n-3 PUFA) lower dopamine neurotransmission as measured by striatal vesicular monoamine transporter type 2 (VMAT2) density and amphetamine-induced dopamine release. Fatty Acids, Omega-3 52-87 pumilio RNA binding family member 3 Homo sapiens 93-97 22698270-2 2012 However, both the n-3 LC-PUFA and the short-chain C18 PUFA (i.e., ALA) are commonly referred to as "omega-3" fatty acids, and it is difficult for consumers to recognize this difference. Fatty Acids, Omega-3 100-120 pumilio RNA binding family member 3 Homo sapiens 25-29 22698270-2 2012 However, both the n-3 LC-PUFA and the short-chain C18 PUFA (i.e., ALA) are commonly referred to as "omega-3" fatty acids, and it is difficult for consumers to recognize this difference. Fatty Acids, Omega-3 100-120 pumilio RNA binding family member 3 Homo sapiens 54-58 22698270-3 2012 A current gap of many food labelling legislations worldwide allow products containing only ALA and without n-3 LC-PUFA to be marketed as "omega-3 source" and this misleading information can negatively impact the ability of consumers to choose more healthy diets. Fatty Acids, Omega-3 138-145 pumilio RNA binding family member 3 Homo sapiens 114-118 23304508-4 2012 In this paper, we highlight genes including apolipoprotein E (APOE), brain derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) along with dietary omega-3 fatty acid, docosahexaenoic acid (DHA), as potential moderators of the effect of physical activity on brain health. Fatty Acids, Omega-3 170-188 apolipoprotein E Homo sapiens 62-66 22442634-0 2012 Attenuation of niacin-induced prostaglandin D(2) generation by omega-3 fatty acids in THP-1 macrophages and Langerhans dendritic cells. Fatty Acids, Omega-3 63-82 GLI family zinc finger 2 Homo sapiens 86-91 22975950-11 2012 These results indicate a highly specific role of CYP-eicosanoids in preventing thromboembolic events and suggest that the formation of 17,18-EEQ and 19,20-EDP may contribute to the anti-thrombotic effects of omega-3 fatty acids. Fatty Acids, Omega-3 208-227 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-52 23095320-1 2012 BACKGROUND/AIM: The effects of omega-3 fatty acids (O3FAs) on renal function and proteinuria in immunoglobulin A nephropathy (IgAN) are not fully understood. Fatty Acids, Omega-3 31-50 IGAN1 Homo sapiens 126-130 23095320-1 2012 BACKGROUND/AIM: The effects of omega-3 fatty acids (O3FAs) on renal function and proteinuria in immunoglobulin A nephropathy (IgAN) are not fully understood. Fatty Acids, Omega-3 52-57 IGAN1 Homo sapiens 126-130 23095320-2 2012 Thus, we conducted an up-to-date meta-analysis of the currently available randomized controlled trials (RCTs) to validate the effects of O3FA in IgAN. Fatty Acids, Omega-3 137-141 IGAN1 Homo sapiens 145-149 23095320-3 2012 METHODS: A literature search was performed in PubMed, Medline, Embase and the Cochrane Central Registry of Controlled Trials using an extended search strategy to identify RCTs that assessed the treatment efficacy of O3FA in IgAN. Fatty Acids, Omega-3 216-220 IGAN1 Homo sapiens 224-228 23056476-1 2012 Studies in rodents indicate that diets deficient in omega-3 polyunsaturated fatty acids (n-3 PUFA) lower dopamine neurotransmission as measured by striatal vesicular monoamine transporter type 2 (VMAT2) density and amphetamine-induced dopamine release. Fatty Acids, Omega-3 52-87 solute carrier family 18 member A2 Homo sapiens 156-194 23056476-1 2012 Studies in rodents indicate that diets deficient in omega-3 polyunsaturated fatty acids (n-3 PUFA) lower dopamine neurotransmission as measured by striatal vesicular monoamine transporter type 2 (VMAT2) density and amphetamine-induced dopamine release. Fatty Acids, Omega-3 52-87 solute carrier family 18 member A2 Homo sapiens 196-201 22133376-6 2012 mRNA level of Delta5 desaturase reverts back to the levels of the control group as a result of omega 3 fatty acid supplementation. Fatty Acids, Omega-3 95-113 fatty acid desaturase 1 Rattus norvegicus 14-31 22848573-1 2012 Epidemiological studies and interventional clinical trials indicate that consumption of long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) such as docosahexaenoic acid (DHA) lengthen gestational duration. Fatty Acids, Omega-3 99-130 pumilio RNA binding family member 3 Homo sapiens 139-143 22629455-8 2012 Linear regression modeling was used to assess the association between lipid levels, n-3 fatty acid intake and FADS genotype. Fatty Acids, Omega-3 84-98 stearoyl-CoA desaturase Homo sapiens 110-114 22047910-0 2012 Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. Fatty Acids, Omega-3 0-18 stearoyl-CoA desaturase Rattus norvegicus 40-63 23193480-2 2012 To determine the relationship between dietary omega-3 fatty acids (n-3 PUFA) and omega-6 fatty acids (n-6 PUFA) with prostate cancer risk from meta-analysis of prospective studies. Fatty Acids, Omega-3 46-65 pumilio RNA binding family member 3 Homo sapiens 71-75 22047910-9 2012 These preclinical findings demonstrate that n-3 fatty acid status is an important determinant of liver Scd1 mRNA expression and activity, and suggest that down-regulation of Scd1 is a mechanism by which n-3 fatty acids repress constitutive triglyceride biosynthesis. Fatty Acids, Omega-3 44-58 stearoyl-CoA desaturase Rattus norvegicus 103-107 22489205-5 2012 The Diet 1 : 1 group showed significantly greater percentages of total n-3 PUFA and docosahexaenoic acid in adipose and liver tissue, and this clearly reflected the contribution of n-3 fatty acids from CLO. Fatty Acids, Omega-3 71-79 MAM and LDL receptor class A domain containing 1 Rattus norvegicus 4-10 22047910-9 2012 These preclinical findings demonstrate that n-3 fatty acid status is an important determinant of liver Scd1 mRNA expression and activity, and suggest that down-regulation of Scd1 is a mechanism by which n-3 fatty acids repress constitutive triglyceride biosynthesis. Fatty Acids, Omega-3 203-218 stearoyl-CoA desaturase Rattus norvegicus 103-107 22047910-9 2012 These preclinical findings demonstrate that n-3 fatty acid status is an important determinant of liver Scd1 mRNA expression and activity, and suggest that down-regulation of Scd1 is a mechanism by which n-3 fatty acids repress constitutive triglyceride biosynthesis. Fatty Acids, Omega-3 203-218 stearoyl-CoA desaturase Rattus norvegicus 174-178 22489205-5 2012 The Diet 1 : 1 group showed significantly greater percentages of total n-3 PUFA and docosahexaenoic acid in adipose and liver tissue, and this clearly reflected the contribution of n-3 fatty acids from CLO. Fatty Acids, Omega-3 181-196 MAM and LDL receptor class A domain containing 1 Rattus norvegicus 4-10 21840275-9 2011 Following IR/PHx, omega-3-treated rats exhibited reduced serum ALT levels after 6- and 24-h reperfusion, a reduced hepatic TNF-alpha content, and an improved anti-oxidative capacity. Fatty Acids, Omega-3 18-25 tumor necrosis factor Rattus norvegicus 123-132 22536073-13 2012 CONCLUSION: "Directly observed treatment" with an omega-3 based supplement (as opposed to a pure protein supplement) showed beneficial effects on the lipid profile, and C-reactive protein levels. Fatty Acids, Omega-3 50-57 C-reactive protein Homo sapiens 169-187 22206437-0 2011 Fat-1 transgenic cattle as a model to study the function of omega-3 fatty acids. Fatty Acids, Omega-3 60-79 FAT atypical cadherin 1 Bos taurus 0-5 22206437-3 2011 In this context, fat-1 transgenic cattle was designed to convert omega-6 to omega-3 fatty acids could form an ideal model to study the effect of omega-3 fatty acids on the above functions. Fatty Acids, Omega-3 76-95 FAT atypical cadherin 1 Bos taurus 17-22 22206437-3 2011 In this context, fat-1 transgenic cattle was designed to convert omega-6 to omega-3 fatty acids could form an ideal model to study the effect of omega-3 fatty acids on the above functions. Fatty Acids, Omega-3 145-164 FAT atypical cadherin 1 Bos taurus 17-22 23017722-6 2012 In this chapter, we present a comprehensive analysis of the effects of the available classes of lipid-lowering drugs (statins, fibrates, niacin, and omega-3-fatty acids) on circulating adiponectin and the known mechanisms which produce these important events. Fatty Acids, Omega-3 149-168 adiponectin, C1Q and collagen domain containing Homo sapiens 185-196 21828168-1 2011 Suboptimal omega-3 polyunsaturated fatty acid (n-3 PUFA) levels may contribute to attention deficit hyperactivity disorder (ADHD) and related developmental problems. Fatty Acids, Omega-3 11-45 pumilio RNA binding family member 3 Homo sapiens 51-55 22078495-9 2011 The association analysis identified the gene variant in intron 5 of the ACSL1 gene (c.481-233A>G) to be significantly associated with the relative content of distinct fractions and ratios of fatty acids (e.g., n-3 fatty acids, polyunsaturated, n-3 long-chain polyunsaturated fatty acids, trans vaccenic acid) in skeletal muscle. Fatty Acids, Omega-3 213-228 fatty-acid-Coenzyme A ligase long chain 2 Bos taurus 72-77 21980057-7 2011 Omega-3 fatty acids decreased by nearly one half relative to omega-6 fatty acids in PTB knockdown cells compared with controls, with a particularly strong decrease in eicosapentaenoic acid (EPA) concentration and its ratio to arachidonic acid (ARA). Fatty Acids, Omega-3 0-19 polypyrimidine tract binding protein 1 Homo sapiens 84-87 22172813-0 2011 Effects of n-3 polyunsaturated fatty acids on rat livers after partial hepatectomy via LKB1-AMPK signaling pathway. Fatty Acids, Omega-3 11-42 serine/threonine kinase 11 Rattus norvegicus 87-91 22172813-7 2011 We observed treatment with n-3 PUFA to activated the LKB1-AMPK signaling pathway as well as to earlier, stronger and prolonged of the expression of Occludin, Claudin-3, zonula occludens-1, and proliferating cell nuclear antigen proteins. Fatty Acids, Omega-3 27-35 serine/threonine kinase 11 Rattus norvegicus 53-57 22172813-7 2011 We observed treatment with n-3 PUFA to activated the LKB1-AMPK signaling pathway as well as to earlier, stronger and prolonged of the expression of Occludin, Claudin-3, zonula occludens-1, and proliferating cell nuclear antigen proteins. Fatty Acids, Omega-3 27-35 occludin Rattus norvegicus 148-156 22172813-7 2011 We observed treatment with n-3 PUFA to activated the LKB1-AMPK signaling pathway as well as to earlier, stronger and prolonged of the expression of Occludin, Claudin-3, zonula occludens-1, and proliferating cell nuclear antigen proteins. Fatty Acids, Omega-3 27-35 claudin 3 Rattus norvegicus 158-187 21791621-7 2011 High LC n-3 fatty acid in rat milk was associated with lower hepatic Pklr, Acly, Fasn, and Scd1 and higher Hmgcs2 in the milk-fed rat neonate, with no effect of milk 18:1n-9, 18:2n-6, or MCFA. Fatty Acids, Omega-3 8-22 pyruvate kinase L/R Rattus norvegicus 69-73 21791621-7 2011 High LC n-3 fatty acid in rat milk was associated with lower hepatic Pklr, Acly, Fasn, and Scd1 and higher Hmgcs2 in the milk-fed rat neonate, with no effect of milk 18:1n-9, 18:2n-6, or MCFA. Fatty Acids, Omega-3 8-22 ATP citrate lyase Rattus norvegicus 75-79 21791621-7 2011 High LC n-3 fatty acid in rat milk was associated with lower hepatic Pklr, Acly, Fasn, and Scd1 and higher Hmgcs2 in the milk-fed rat neonate, with no effect of milk 18:1n-9, 18:2n-6, or MCFA. Fatty Acids, Omega-3 8-22 fatty acid synthase Rattus norvegicus 81-85 21791621-7 2011 High LC n-3 fatty acid in rat milk was associated with lower hepatic Pklr, Acly, Fasn, and Scd1 and higher Hmgcs2 in the milk-fed rat neonate, with no effect of milk 18:1n-9, 18:2n-6, or MCFA. Fatty Acids, Omega-3 8-22 stearoyl-CoA desaturase Rattus norvegicus 91-95 21791621-7 2011 High LC n-3 fatty acid in rat milk was associated with lower hepatic Pklr, Acly, Fasn, and Scd1 and higher Hmgcs2 in the milk-fed rat neonate, with no effect of milk 18:1n-9, 18:2n-6, or MCFA. Fatty Acids, Omega-3 8-22 3-hydroxy-3-methylglutaryl-CoA synthase 2 Rattus norvegicus 107-113 22291823-0 2011 N-3 Polyunsaturated fatty acid therapy improves endothelial function and affects adiponectin and resistin balance in the first month after myocardial infarction. Fatty Acids, Omega-3 0-30 adiponectin, C1Q and collagen domain containing Homo sapiens 81-92 21870174-12 2011 A greater increase in plasma concentration of very-long-chain n-3 fatty acids and in the intake of fibre during the study was associated with a greater decrease in plasma E-selectin (p < 0.05). Fatty Acids, Omega-3 62-77 selectin E Homo sapiens 171-181 21938553-9 2011 Primary cultured astrocytes from FABP7-KO mice also showed a significant decrease in proliferation and omega-3 fatty acid incorporation compared with wild-type astrocytes. Fatty Acids, Omega-3 103-121 fatty acid binding protein 7, brain Mus musculus 33-38 21945326-0 2011 CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? Fatty Acids, Omega-3 36-55 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 0-3 22291823-0 2011 N-3 Polyunsaturated fatty acid therapy improves endothelial function and affects adiponectin and resistin balance in the first month after myocardial infarction. Fatty Acids, Omega-3 0-30 resistin Homo sapiens 97-105 22291823-1 2011 INTRODUCTION: N-3 Polyunsaturated fatty acids (n-3 PUFA) exert clinical beneficial effects in patients after acute myocardial infarction (AMI). Fatty Acids, Omega-3 14-45 pumilio RNA binding family member 3 Homo sapiens 51-55 21779875-0 2011 The n3-polyunsaturated fatty acid docosahexaenoic acid induces immunogenic cell death in human cancer cell lines via pre-apoptotic calreticulin exposure. Fatty Acids, Omega-3 4-33 calreticulin Homo sapiens 131-143 21771724-0 2011 Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Fatty Acids, Omega-3 0-19 syndecan 1 Mus musculus 99-109 21779875-3 2011 We investigated the ability of the n3-polyunsaturated fatty acid docosahexaenoic acid (22:6n3, DHA) to induce pre-apoptotic CRT exposure on the surface of the human PaCa-44 pancreatic and EJ bladder cancer cell lines. Fatty Acids, Omega-3 35-64 calreticulin Homo sapiens 124-127 20548327-1 2011 The cyclooxygenase (COX) activity of prostaglandin H synthase-2 (PGHS-2) is implicated in colorectal cancer and is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) and dietary n-3 fatty acids. Fatty Acids, Omega-3 185-200 prostaglandin-endoperoxide synthase 2 Homo sapiens 37-63 21771724-0 2011 Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Fatty Acids, Omega-3 0-19 mitogen-activated protein kinase kinase 7 Homo sapiens 128-131 21771724-0 2011 Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Fatty Acids, Omega-3 0-19 mitogen-activated protein kinase 1 Mus musculus 132-135 21771724-1 2011 Human epidemiological studies have shown that diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFA) are associated with a lower incidence of cancers including breast cancer. Fatty Acids, Omega-3 64-95 pumilio RNA binding family member 3 Homo sapiens 101-105 20548327-1 2011 The cyclooxygenase (COX) activity of prostaglandin H synthase-2 (PGHS-2) is implicated in colorectal cancer and is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) and dietary n-3 fatty acids. Fatty Acids, Omega-3 185-200 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-71 20548327-7 2011 Thus, the E488G and V511A PGHS-2 polymorphisms may predict who will most likely benefit from interventions with some NSAIDs or n-3 fatty acids. Fatty Acids, Omega-3 127-142 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-32 21879986-1 2011 OBJECTIVE: To determine associations between serum concentrations of omega-3 polyunsaturated fatty acids and concentrations of adiponectin, leptin, and insulin in healthy cats. Fatty Acids, Omega-3 69-104 adiponectin, C1Q and collagen domain containing Felis catus 127-138 21762726-4 2011 Evidence for pharmacological responses and the mechanism of action of each of the n-3 fatty acid trio will be discussed for the major risk factors of metabolic syndrome, especially adiposity, dyslipidemia, insulin resistance and diabetes, hypertension, oxidative stress, and inflammation. Fatty Acids, Omega-3 82-96 insulin Homo sapiens 206-213 21768100-0 2011 Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol. Fatty Acids, Omega-3 150-165 solute carrier family 27 member 2 Homo sapiens 38-73 21768100-0 2011 Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol. Fatty Acids, Omega-3 150-165 solute carrier family 27 member 2 Homo sapiens 84-90 21768100-6 2011 The use of stable isotopically labeled fatty acids demonstrated FATP2a is involved in the uptake and activation of exogenous fatty acids, with a preference toward n-3 fatty acids (C18:3 and C22:6). Fatty Acids, Omega-3 163-178 solute carrier family 27 (fatty acid transporter), member 2 Mus musculus 64-69 21768100-9 2011 Collectively these data demonstrate FATP2a functions in fatty acid transport and activation and provides specificity toward n-3 fatty acids in which the corresponding n-3 acyl-CoAs are preferentially trafficked into acyl-CoA pools destined for phosphatidylinositol incorporation. Fatty Acids, Omega-3 124-139 solute carrier family 27 member 2 Homo sapiens 36-41 21879986-1 2011 OBJECTIVE: To determine associations between serum concentrations of omega-3 polyunsaturated fatty acids and concentrations of adiponectin, leptin, and insulin in healthy cats. Fatty Acids, Omega-3 69-104 leptin Felis catus 140-146 21879986-1 2011 OBJECTIVE: To determine associations between serum concentrations of omega-3 polyunsaturated fatty acids and concentrations of adiponectin, leptin, and insulin in healthy cats. Fatty Acids, Omega-3 69-104 insulin Felis catus 152-159 21704188-0 2011 n-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice. Fatty Acids, Omega-3 0-15 nuclear receptor subfamily 1, group H, member 3 Mus musculus 67-70 21616147-0 2011 Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. Fatty Acids, Omega-3 36-55 FAT atypical cadherin 1 Mus musculus 0-5 21663979-3 2011 We have recently shown that GPR120 acts as a physiological receptor of omega3 fatty acids in macrophages and adipocytes, which mediate potent anti-inflammatory and insulin sensitizing effects. Fatty Acids, Omega-3 71-89 insulin Homo sapiens 164-171 21775525-0 2011 Ingestion of (n-3) fatty acids augments basal and platelet activating factor-induced permeability to dextran in the rat mesenteric vascular bed. Fatty Acids, Omega-3 13-30 PCNA clamp associated factor Rattus norvegicus 50-76 21775525-4 2011 We hypothesized that dietary (n-3) FA would ameliorate PAF-induced vasoconstriction and enhance vascular leakage of dextran tracers. Fatty Acids, Omega-3 29-37 PCNA clamp associated factor Rattus norvegicus 55-58 22024496-2 2011 It was hypothesized that chronic n-3 fatty acid deficiency would increase liver Fads1 and Fads2 messenger RNA (mRNA) expression/activity and that n-3 fatty acid repletion would normalize this response. Fatty Acids, Omega-3 33-47 fatty acid desaturase 1 Rattus norvegicus 80-85 22024496-2 2011 It was hypothesized that chronic n-3 fatty acid deficiency would increase liver Fads1 and Fads2 messenger RNA (mRNA) expression/activity and that n-3 fatty acid repletion would normalize this response. Fatty Acids, Omega-3 33-47 fatty acid desaturase 2 Rattus norvegicus 90-95 22024496-8 2011 These results confirm previous findings that liver, but not brain, delta6-desaturase expression and activity indices are negatively regulated by dietary n-3 fatty acids. Fatty Acids, Omega-3 153-168 fatty acid desaturase 2 Rattus norvegicus 67-84 21800004-0 2011 Dose-dependent decrease of platelet activation and tissue factor by omega-3 polyunsaturated fatty acids in patients with advanced chronic heart failure. Fatty Acids, Omega-3 68-103 coagulation factor III, tissue factor Homo sapiens 51-64 21800004-2 2011 Treatment with omega-3 polyunsaturated fatty acids (n3-PUFA) showed significant benefits including mortality reduction in CHF, but exact mechanisms of action are still unclear. Fatty Acids, Omega-3 15-50 pumilio RNA binding family member 3 Homo sapiens 55-59 21871057-9 2011 Alpha-linolenic acid (ALA), the major n-3 polyunsaturated fatty acids found in walnuts, recaptured SCD1 reduction in MDFC, a mechanism mediated through activation of nuclear receptor farnesoid-X-receptor (FXR). Fatty Acids, Omega-3 38-69 stearoyl-CoA desaturase Homo sapiens 99-103 21871057-9 2011 Alpha-linolenic acid (ALA), the major n-3 polyunsaturated fatty acids found in walnuts, recaptured SCD1 reduction in MDFC, a mechanism mediated through activation of nuclear receptor farnesoid-X-receptor (FXR). Fatty Acids, Omega-3 38-69 nuclear receptor subfamily 1 group H member 4 Homo sapiens 205-208 21854591-11 2011 CONCLUSIONS: Omega-3 fatty acids showed a protective effects on PPA - induced changes in rats as there was a remarkable amelioration of most of the measured parameters (i.e. higher GABA, 5HT, DA, PE, PS and PC) and lower Il-6, TNF-alpha and caspase-3. Fatty Acids, Omega-3 13-32 tumor necrosis factor Rattus norvegicus 227-236 21605051-2 2011 In the last 10 years, epidemiological, preclinical and clinical data have enlightened the possible preventive action of omega-3 polyunsaturated fatty acids (n-3 PUFA) in AD and other diseases. Fatty Acids, Omega-3 120-155 pumilio RNA binding family member 3 Homo sapiens 161-165 21846343-0 2011 Attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among disaster medical assistance team members after the Great East Japan Earthquake: the APOP randomized controlled trial. Fatty Acids, Omega-3 40-75 cytochrome c oxidase assembly factor 8 Homo sapiens 166-170 21846343-5 2011 METHOD/DESIGN: This study is designed to determine the effectiveness of attenuating posttraumatic distress with omega-3 polyunsaturated fatty acids among Disaster Medical Assistance Team members after the Great East Japan Earthquake, and is named the APOP randomized controlled trial which is currently ongoing. Fatty Acids, Omega-3 112-147 cytochrome c oxidase assembly factor 8 Homo sapiens 251-255 21658782-0 2011 Higher n-3 fatty acids are associated with more intense fenfluramine-induced ACTH and cortisol responses among cocaine-abusing men. Fatty Acids, Omega-3 7-22 proopiomelanocortin Homo sapiens 77-81 21605054-0 2011 Dietary omega 3 polyunsaturated fatty acids and Alzheimer"s disease: interaction with apolipoprotein E genotype. Fatty Acids, Omega-3 8-43 apolipoprotein E Homo sapiens 86-102 21605054-1 2011 Epidemiological studies suggest a protective role of omega-3 poly-unsaturated fatty acids (n-3 PUFA) against Alzheimer"s disease (AD). Fatty Acids, Omega-3 53-89 pumilio RNA binding family member 3 Homo sapiens 95-99 21111596-0 2011 Omega-3 fatty acids attenuate dendritic cell function via NF-kappaB independent of PPARgamma. Fatty Acids, Omega-3 0-19 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 58-67 21854591-11 2011 CONCLUSIONS: Omega-3 fatty acids showed a protective effects on PPA - induced changes in rats as there was a remarkable amelioration of most of the measured parameters (i.e. higher GABA, 5HT, DA, PE, PS and PC) and lower Il-6, TNF-alpha and caspase-3. Fatty Acids, Omega-3 13-32 caspase 3 Rattus norvegicus 241-250 22332072-0 2011 (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Fatty Acids, Omega-3 0-17 insulin Homo sapiens 60-67 21538725-1 2011 BACKGROUND: Previous randomized controlled trials have demonstrated that omega-3 polyunsaturated fatty acids (n-3 PUFA) are beneficial in reducing symptoms of depression. Fatty Acids, Omega-3 73-108 pumilio RNA binding family member 3 Homo sapiens 114-118 21658192-1 2011 BACKGROUND: Maternal supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA) may modulate immune responses and allergy in neonates and children. Fatty Acids, Omega-3 42-77 pumilio RNA binding family member 3 Homo sapiens 83-87 21561620-8 2011 n-3 fatty acids increased the plasma malondialdehyde and SOD activity but reduced catalase expression (p<0.05). Fatty Acids, Omega-3 0-15 superoxide dismutase 1 Homo sapiens 57-60 21617138-1 2011 OBJECTIVE: The goal of this study was to investigate whether omega-3 polyunsaturated fatty acids (n-3 PUFA) are able to alter plasma fibrin clot properties and reduce thrombin formation in stable coronary artery disease patients undergoing percutaneous coronary intervention (PCI). Fatty Acids, Omega-3 61-96 pumilio RNA binding family member 3 Homo sapiens 102-106 21617138-1 2011 OBJECTIVE: The goal of this study was to investigate whether omega-3 polyunsaturated fatty acids (n-3 PUFA) are able to alter plasma fibrin clot properties and reduce thrombin formation in stable coronary artery disease patients undergoing percutaneous coronary intervention (PCI). Fatty Acids, Omega-3 61-96 coagulation factor II, thrombin Homo sapiens 167-175 21543294-6 2011 Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Fatty Acids, Omega-3 10-41 C-reactive protein Homo sapiens 94-112 21569104-4 2011 Omega-3 polyunsaturated fatty acids (n-3 PUFA) are promising candidates, showing potential to protect the skin from UVR injury through a range of mechanisms. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 21205027-10 2011 It is hypothesized that the administration of omega-3 fatty acids in combination with l-carnitine would increase CPT-I activity and improve chronic fatigue syndrome symptomology. Fatty Acids, Omega-3 46-65 carnitine palmitoyltransferase 1B Homo sapiens 113-118 21036590-12 2011 These data suggest that long-term intake of omega-3 FA, particularly EPA, may modestly improve the structural and mechanical properties of cortical bone by an increase in leptin and IGF-1 levels, without affecting trabecular bone loss. Fatty Acids, Omega-3 44-54 insulin-like growth factor 1 Mus musculus 182-187 21444354-9 2011 Whereas, it was seen that there was an increase in SOD and CAT enzyme activities and decrease in MDA, XO, and GSH-Px levels in rats administered to omega-3 fatty acids with exposure of formaldehyde. Fatty Acids, Omega-3 148-167 glutathione peroxidase 1 Rattus norvegicus 110-116 21226540-11 2011 CONCLUSION; The observed association between the omega-3 index, weight status and insulin resistance in children highlights the importance of omega-3 fatty acids in the prevention of obesity-related chronic diseases in later life. Fatty Acids, Omega-3 142-161 insulin Homo sapiens 82-89 21421544-0 2011 Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-alpha. Fatty Acids, Omega-3 59-78 FAT atypical cadherin 1 Mus musculus 34-39 21421544-0 2011 Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-alpha. Fatty Acids, Omega-3 59-78 tumor necrosis factor Mus musculus 152-161 21421544-0 2011 Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-alpha. Fatty Acids, Omega-3 59-66 FAT atypical cadherin 1 Mus musculus 34-39 21421544-0 2011 Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-alpha. Fatty Acids, Omega-3 59-66 tumor necrosis factor Mus musculus 152-161 21421544-4 2011 In this study, we used the fat-1 transgenic mouse model, which endogenously forms n-3 PUFA from n-6 PUFA to determine the effect of an increased n-3 PUFA tissue status on tumor formation in the diethylnitrosamine (DEN)-induced liver tumor model. Fatty Acids, Omega-3 82-90 FAT atypical cadherin 1 Mus musculus 27-32 20817187-0 2011 Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid-induced up-regulation of mitofusin 2. Fatty Acids, Omega-3 78-96 mitofusin 2 Homo sapiens 122-133 22432684-1 2011 There has been limited research to date into methods for increasing people"s intentions to use omega-3 polyunsaturated fatty acids (n-3 PUFA), which have been linked with decreased risk of suffering from numerous major diseases. Fatty Acids, Omega-3 95-130 pumilio RNA binding family member 3 Homo sapiens 136-140 21525263-10 2011 The ex vivo data, which confirm previous studies with EL4 cells, provide evidence that (n-3) PUFA consumed through the diet disrupt B cell lipid raft clustering. Fatty Acids, Omega-3 87-97 epilepsy 4 Mus musculus 54-57 21609458-0 2011 The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters. Fatty Acids, Omega-3 81-90 leptin Mus musculus 18-24 21609458-0 2011 The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters. Fatty Acids, Omega-3 81-90 leptin receptor Mus musculus 26-41 21609458-0 2011 The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters. Fatty Acids, Omega-3 81-90 pro-opiomelanocortin-alpha Mus musculus 46-66 21609458-1 2011 BACKGROUND: The expression of leptin is increased in obesity and inhibited by n-3 polyunsaturated fatty acids (n-3 PUFAs), but the underlying molecular mechanisms have not been firmly established. Fatty Acids, Omega-3 78-109 leptin Mus musculus 30-36 21609458-1 2011 BACKGROUND: The expression of leptin is increased in obesity and inhibited by n-3 polyunsaturated fatty acids (n-3 PUFAs), but the underlying molecular mechanisms have not been firmly established. Fatty Acids, Omega-3 111-120 leptin Mus musculus 30-36 21477296-1 2011 BACKGROUND: Medium-chain triacylglycerols (MCT), omega-3 polyunsaturated fatty acids (n-3-PUFA) and micronutrients may be useful for weight and cardiometabolic risk management. Fatty Acids, Omega-3 49-84 pumilio RNA binding family member 3 Homo sapiens 90-94 21569413-11 2011 Both EPA and DHA reduce the activation of EGFR.N-3 fatty acids are partially metabolized in both cell lines; AA is integrated without being further metabolized. Fatty Acids, Omega-3 47-62 epidermal growth factor receptor Homo sapiens 42-46 21367920-0 2011 n-3 Fatty acids block TNF-alpha-stimulated MCP-1 expression in rat mesangial cells. Fatty Acids, Omega-3 0-15 tumor necrosis factor Mus musculus 22-31 21367920-0 2011 n-3 Fatty acids block TNF-alpha-stimulated MCP-1 expression in rat mesangial cells. Fatty Acids, Omega-3 0-15 chemokine (C-C motif) ligand 2 Mus musculus 43-48 21367920-6 2011 Cultured mesangial cells were treated with TNF-alpha in the presence of the n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA); equimolar concentrations of the n-6 fatty acids LA and OA served as controls. Fatty Acids, Omega-3 76-91 tumor necrosis factor Mus musculus 43-52 21138533-3 2011 Here, we tested whether combined omega 3 polyunsaturated fatty acids (n-3 PUFA)-antioxidant vitamin protocol therapy reduces oxidative and inflammatory cardiac tissue damage. Fatty Acids, Omega-3 33-68 pumilio RNA binding family member 3 Homo sapiens 74-78 21311505-1 2011 BACKGROUND: Effects of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) intake on the cardiovascular system have been reported, and thus we hypothesized that the prevalence of hypertensive cardiovascular remodeling would be lower in a fishing than a farming community. Fatty Acids, Omega-3 31-62 pumilio RNA binding family member 3 Homo sapiens 68-72 21330635-0 2011 High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition. Fatty Acids, Omega-3 16-31 FAT atypical cadherin 1 Mus musculus 64-69 21330635-2 2011 We therefore evaluated whether fat-1 transgenic mice, a well-controlled experimental model endogenously synthesizing n-3 PUFA, were protected against streptozotocin (STZ)-induced diabetes. Fatty Acids, Omega-3 117-125 FAT atypical cadherin 1 Mus musculus 31-36 21749023-6 2011 Women in the highest adiponectin tertile had a lower dietary intake of omega-3-fatty acid compared to those with lower adiponectin levels (P < .005). Fatty Acids, Omega-3 71-89 adiponectin, C1Q and collagen domain containing Homo sapiens 21-32 21236358-1 2011 Mass spectrometry techniques have enabled the identification of different lipid metabolites and mediators derived from omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFA) that are implicated in various biological processes. Fatty Acids, Omega-3 131-166 pumilio RNA binding family member 3 Homo sapiens 180-184 20655721-0 2011 Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice. Fatty Acids, Omega-3 92-101 prostaglandin-endoperoxide synthase 2 Mus musculus 0-5 20655721-0 2011 Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice. Fatty Acids, Omega-3 92-101 FAT atypical cadherin 1 Mus musculus 123-128 21217086-5 2011 RESULTS: There was an inverse association, showing a dose-response relationship, between total n-3 fatty acid serum concentrations and p53 immunoreactivity in the whole epidermis and the basal layer. Fatty Acids, Omega-3 95-109 tumor protein p53 Homo sapiens 135-138 21299240-1 2011 The importance of n-3 polyunsaturated fatty acid (n-3 PUFA) intake has long been recognized in human nutrition. Fatty Acids, Omega-3 18-48 pumilio RNA binding family member 3 Homo sapiens 54-58 20532624-2 2011 Transgenic female mice expressing the Fat-1 gene under transcriptional control of the goat beta-casein promoter produce milk phospholipids having elevated levels of n-3 polyunsaturated fatty acids (PUFA). Fatty Acids, Omega-3 165-196 FAT atypical cadherin 1 Mus musculus 38-43 21773019-0 2011 Peroxidation of n-3 Polyunsaturated Fatty Acids Inhibits the Induction of iNOS Gene Expression in Proinflammatory Cytokine-Stimulated Hepatocytes. Fatty Acids, Omega-3 16-47 nitric oxide synthase 2 Homo sapiens 74-78 21329629-0 2011 Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients. Fatty Acids, Omega-3 72-79 adiponectin, C1Q and collagen domain containing Homo sapiens 15-26 21329629-0 2011 Association of adiponectin and leptin with serum lipids and erythrocyte omega-3 and omega-6 fatty acids in dialysis patients. Fatty Acids, Omega-3 72-79 leptin Homo sapiens 31-37 21099447-0 2011 Th1 and Th2 chemokines, vaccine-induced immunity, and allergic disease in infants after maternal omega-3 fatty acid supplementation during pregnancy and lactation. Fatty Acids, Omega-3 97-115 negative elongation factor complex member C/D Homo sapiens 0-3 21099447-1 2011 We investigated whether the previously reported preventive effect of maternal omega-3 fatty acid supplementation on IgE-associated allergic disease in infancy may be mediated by facilitating a balanced circulating Th2/Th1 chemokine profile in the infant. Fatty Acids, Omega-3 78-96 negative elongation factor complex member C/D Homo sapiens 218-221 21099447-7 2011 Furthermore, in nonallergic, but not in allergic infants, omega-3 supplementation was linked with higher Th1-associated CXCL11 levels (p < 0.05), as well as increased IgG titers to diphtheria (p = 0.01) and tetanus (p = 0.05) toxins. Fatty Acids, Omega-3 58-65 negative elongation factor complex member C/D Homo sapiens 105-108 21099447-7 2011 Furthermore, in nonallergic, but not in allergic infants, omega-3 supplementation was linked with higher Th1-associated CXCL11 levels (p < 0.05), as well as increased IgG titers to diphtheria (p = 0.01) and tetanus (p = 0.05) toxins. Fatty Acids, Omega-3 58-65 C-X-C motif chemokine ligand 11 Homo sapiens 120-126 20573493-1 2011 This study was conducted to test the hypothesis that n-3 polyunsaturated fatty acids are able to down-regulate expression of adhesion molecules and nuclear factor-kappaB (NF-kappaB) activation in vascular endothelial cells, in addition to reducing atherosclerotic lesions in vivo. Fatty Acids, Omega-3 53-84 nuclear factor kappa B subunit 1 Homo sapiens 148-169 20573493-1 2011 This study was conducted to test the hypothesis that n-3 polyunsaturated fatty acids are able to down-regulate expression of adhesion molecules and nuclear factor-kappaB (NF-kappaB) activation in vascular endothelial cells, in addition to reducing atherosclerotic lesions in vivo. Fatty Acids, Omega-3 53-84 nuclear factor kappa B subunit 1 Homo sapiens 171-180 20635852-14 2011 Similarly, immunohistochemical analysis of caspase-3 expression demonstrated significant (p < 0.05) reduction in animals receiving O3FA supplementation, 18.5 +- 28.3 axons per mm(2) in the 10 mg/kg/day group and 13.8 +- 18.9 axons per mm(2) in the 40 mg/kg/day group, versus 129.3 +- 49.1 axons per mm(2) in unsupplemented animals. Fatty Acids, Omega-3 134-138 caspase 3 Rattus norvegicus 43-52 20863572-1 2011 BACKGROUND: Major depressive disorder (MDD) is associated with central and peripheral deficits in long-chain polyunsaturated fatty acids (LC-PUFA), particularly those in the omega-3 fatty acid family. Fatty Acids, Omega-3 174-192 pumilio RNA binding family member 3 Homo sapiens 141-145 21282499-0 2011 Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts. Fatty Acids, Omega-3 0-19 5'-nucleotidase, cytosolic II Mus musculus 100-103 21282499-13 2011 CONCLUSION: Omega-3 fatty acids prevent cardiac fibrosis and cardiac dysfunction by blocking transforming growth factor-beta1-induced phospho-Smad2/3 nuclear translocation through activation of the cyclic GMP/protein kinase G pathway in cardiac fibroblasts. Fatty Acids, Omega-3 12-31 transforming growth factor, beta 1 Mus musculus 93-125 21282499-13 2011 CONCLUSION: Omega-3 fatty acids prevent cardiac fibrosis and cardiac dysfunction by blocking transforming growth factor-beta1-induced phospho-Smad2/3 nuclear translocation through activation of the cyclic GMP/protein kinase G pathway in cardiac fibroblasts. Fatty Acids, Omega-3 12-31 SMAD family member 2 Mus musculus 142-147 21282499-13 2011 CONCLUSION: Omega-3 fatty acids prevent cardiac fibrosis and cardiac dysfunction by blocking transforming growth factor-beta1-induced phospho-Smad2/3 nuclear translocation through activation of the cyclic GMP/protein kinase G pathway in cardiac fibroblasts. Fatty Acids, Omega-3 12-31 5'-nucleotidase, cytosolic II Mus musculus 205-208 21799946-0 2011 The effects of omega-3 Fatty acids on matrix metalloproteinase-9 production and cell migration in human immune cells: implications for multiple sclerosis. Fatty Acids, Omega-3 15-34 matrix metallopeptidase 9 Homo sapiens 38-64 21799946-3 2011 The aim of this paper was to evaluate the effects of omega-3 fatty acids on MMP-9 levels and T cell migration. Fatty Acids, Omega-3 53-72 matrix metallopeptidase 9 Homo sapiens 76-81 21799946-8 2011 The data suggest that omega-3 fatty acids may benefit patients with multiple sclerosis by modulating immune cell production of MMP-9. Fatty Acids, Omega-3 22-41 matrix metallopeptidase 9 Homo sapiens 127-132 21914946-1 2011 Dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) reduces amyloid-beta (Abeta) and tau pathology and improves cognitive performance in animal models of Alzheimer"s disease (AD). Fatty Acids, Omega-3 29-60 amyloid beta (A4) precursor protein Mus musculus 94-99 21914946-1 2011 Dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) reduces amyloid-beta (Abeta) and tau pathology and improves cognitive performance in animal models of Alzheimer"s disease (AD). Fatty Acids, Omega-3 62-70 amyloid beta (A4) precursor protein Mus musculus 94-99 20797725-1 2011 OBJECTIVE: To assess the long-term effect on visual development of omega-3 polyunsaturated fatty acid (n-3 PUFA) intake during gestation. Fatty Acids, Omega-3 67-101 pumilio RNA binding family member 3 Homo sapiens 107-111 22141190-4 2011 Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults. Fatty Acids, Omega-3 0-19 brain derived neurotrophic factor Homo sapiens 103-136 21667400-0 2011 Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. Fatty Acids, Omega-3 0-18 mechanistic target of rapamycin kinase Homo sapiens 119-123 21667400-0 2011 Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. Fatty Acids, Omega-3 0-18 androgen receptor Homo sapiens 138-155 21183832-1 2011 The purpose of this study was to determine if Omega 3 Chia seed loading is a viable option for enhancing sports performance in events lasting >90 minutes and allow athletes to decrease their dietary intake of sugar while increasing their intake of Omega 3 fatty acids. Fatty Acids, Omega-3 251-270 chitinase acidic Homo sapiens 54-58 21183832-10 2011 Under our conditions, Omega 3 Chia loading appears a viable option for enhancing performance for endurance events lasting >90 minutes and allows athletes to decrease their dietary intake of sugar while increasing their intake of Omega 3 fatty acids but offered no performance advantages. Fatty Acids, Omega-3 232-251 chitinase acidic Homo sapiens 30-34 21547255-5 2011 Serum GAS and MTL levels in omega-3 fatty acid group were higher than those in normal saline group, but serum IL-1, IL-6, TNF-alpha, and COX-2 levels were lower than those in normal saline group and intralipid group. Fatty Acids, Omega-3 28-46 gastrin Rattus norvegicus 6-9 21547255-5 2011 Serum GAS and MTL levels in omega-3 fatty acid group were higher than those in normal saline group, but serum IL-1, IL-6, TNF-alpha, and COX-2 levels were lower than those in normal saline group and intralipid group. Fatty Acids, Omega-3 28-46 motilin Rattus norvegicus 14-17 22141190-4 2011 Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults. Fatty Acids, Omega-3 0-19 brain derived neurotrophic factor Homo sapiens 138-142 21674002-3 2011 Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been of considerable interest, due to their potential to reduce metabolic syndrome (MetS) risk. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 21655218-0 2011 Endogenous synthesis of n-3 polyunsaturated fatty acids in Fat-1 mice is associated with increased mammary gland and liver syndecan-1. Fatty Acids, Omega-3 24-55 FAT atypical cadherin 1 Mus musculus 59-64 20930167-0 2010 n-3 Fatty acids decrease arterial low-density lipoprotein cholesterol delivery and lipoprotein lipase levels in insulin-resistant mice. Fatty Acids, Omega-3 0-15 lipoprotein lipase Mus musculus 83-101 21655218-0 2011 Endogenous synthesis of n-3 polyunsaturated fatty acids in Fat-1 mice is associated with increased mammary gland and liver syndecan-1. Fatty Acids, Omega-3 24-55 syndecan 1 Mus musculus 123-133 21720194-0 2011 Potential role of brain-derived neurotrophic factor in omega-3 Fatty Acid supplementation to prevent posttraumatic distress after accidental injury: an open-label pilot study. Fatty Acids, Omega-3 55-73 brain derived neurotrophic factor Homo sapiens 18-51 21209961-6 2010 A conjugate of PS and an omega-3 fatty acid also increased IKAP mRNA levels. Fatty Acids, Omega-3 25-43 elongator acetyltransferase complex subunit 1 Homo sapiens 59-63 20705919-3 2010 The fat-1 transgenic mouse model, expressing an n-3 fatty acid desaturase, is capable of producing n-3 PUFAs from n-6 PUFAs and thereby has a ratio of n-6/n-3 fatty acids close to 1:1 in tissues and organs. Fatty Acids, Omega-3 99-108 FAT atypical cadherin 1 Mus musculus 4-9 20705919-3 2010 The fat-1 transgenic mouse model, expressing an n-3 fatty acid desaturase, is capable of producing n-3 PUFAs from n-6 PUFAs and thereby has a ratio of n-6/n-3 fatty acids close to 1:1 in tissues and organs. Fatty Acids, Omega-3 155-170 FAT atypical cadherin 1 Mus musculus 4-9 21147363-1 2010 N-3 polyunsaturated fatty acids (PUFAs) are known to have antihypertensive properties, but the association between 24-hour ambulatory blood pressure and the tissue content of n-3 PUFA remains controversial. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 33-37 20841610-3 2010 RESEARCH DESIGN AND METHODS: We used transgenic expression of the fat-1 n-3 fatty acid desaturase from C. elegans to endogenously restore n-3 fatty acids in HF-fed mice. Fatty Acids, Omega-3 138-153 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 66-75 20465434-7 2010 CONCLUSION: The results of this preliminary study showed that long-term consumption of olive oil enriched with n-3 PUFA in patients with NAFLD is able to decrease circulating liver enzymes and triglycerides, with a significant improvement of adiponectin levels. Fatty Acids, Omega-3 111-119 adiponectin, C1Q and collagen domain containing Homo sapiens 242-253 21313786-0 2010 [Ameliorative effect of n-3 fatty acid on insulin resistance through GPR120]. Fatty Acids, Omega-3 24-38 insulin Homo sapiens 42-49 21313786-0 2010 [Ameliorative effect of n-3 fatty acid on insulin resistance through GPR120]. Fatty Acids, Omega-3 24-38 free fatty acid receptor 4 Homo sapiens 69-75 20919854-2 2010 Compared to mice fed a standard diet, TLL mice fed omega-3 (menhaden fish oil) experienced a significant delay in disease progression and were more likely to remain alive and symptom free during the first 8 months of the study. Fatty Acids, Omega-3 51-58 tolloid-like Mus musculus 38-41 21147655-12 2010 CONCLUSION: A comparative analysis of diary records (omega-3 fatty acids & PANAS) and cardiovascular responses (Sphygmochron) showed that a person who is professionally and socially active in middle age can actively reduce her SBP/DBP with omega-3 fatty acids intervention. Fatty Acids, Omega-3 53-72 selenium binding protein 1 Homo sapiens 231-234 20180775-8 2010 Niacin, omega-3 fatty acids, plant sterols and bezafibrate primarily act by increasing PPAR-gamma activity and possibly by reducing oxidative stress or inflammation. Fatty Acids, Omega-3 8-27 peroxisome proliferator activated receptor gamma Homo sapiens 87-97 21147655-12 2010 CONCLUSION: A comparative analysis of diary records (omega-3 fatty acids & PANAS) and cardiovascular responses (Sphygmochron) showed that a person who is professionally and socially active in middle age can actively reduce her SBP/DBP with omega-3 fatty acids intervention. Fatty Acids, Omega-3 244-263 selenium binding protein 1 Homo sapiens 231-234 20393761-0 2010 Endogenously produced n-3 fatty acids protect against ovariectomy induced bone loss in fat-1 transgenic mice. Fatty Acids, Omega-3 22-37 FAT atypical cadherin 1 Mus musculus 87-92 21519759-1 2010 This paper compares the pleiotropic effects of statins and omega-3 fatty acids (n-3 PUFA) in treating and preventing cardiovascular disease (CVD) and deals with the possible interactions of those compounds. Fatty Acids, Omega-3 59-78 pumilio RNA binding family member 3 Homo sapiens 84-88 20732876-9 2010 These results demonstrate that CYP enzymes efficiently convert EPA and DHA to novel epoxy and hydroxy metabolites that could mediate some of the beneficial cardiovascular effects of dietary omega-3 fatty acids. Fatty Acids, Omega-3 190-209 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 31-34 20817496-9 2010 Changes in membrane n-3 and n-6 fatty acid composition, elevations in plasma IL-6 and TNFalpha, and increased central 5-HT turnover were all prevented by normalization of n-3 fatty acid status. Fatty Acids, Omega-3 171-185 interleukin 6 Rattus norvegicus 77-81 20732876-0 2010 Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids. Fatty Acids, Omega-3 69-90 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 30-45 20620224-0 2010 Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia. Fatty Acids, Omega-3 99-118 FAT atypical cadherin 1 Homo sapiens 14-19 20651599-9 2010 The omega-3 fatty acid treatment increased serum aspartate aminotransferase significantly, whereas exendin-4 had no effect. Fatty Acids, Omega-3 4-22 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 49-75 20817496-9 2010 Changes in membrane n-3 and n-6 fatty acid composition, elevations in plasma IL-6 and TNFalpha, and increased central 5-HT turnover were all prevented by normalization of n-3 fatty acid status. Fatty Acids, Omega-3 171-185 tumor necrosis factor Rattus norvegicus 86-94 20856881-3 2010 The present study used fat-1 transgenic mice, that are capable of synthesizing n-3 fatty acids, to investigate the influence of increases in n-3 fatty acids and resultant decreases in the n-6:n-3 ratio on liver mitochondrial H(2)O(2) production and electron transport chain (ETC) activity. Fatty Acids, Omega-3 79-94 FAT atypical cadherin 1 Mus musculus 23-28 21537437-4 2010 The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs (statins, fibrates, niacin and omega-3-fatty acids) on the circulating concentrations of leptin, adiponectin, tumor necrosis-factor-alpha (TNF-alpha), Retinol binding protein 4 (RBP4) and resistin. Fatty Acids, Omega-3 136-155 leptin Homo sapiens 194-200 21537437-4 2010 The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs (statins, fibrates, niacin and omega-3-fatty acids) on the circulating concentrations of leptin, adiponectin, tumor necrosis-factor-alpha (TNF-alpha), Retinol binding protein 4 (RBP4) and resistin. Fatty Acids, Omega-3 136-155 tumor necrosis factor Homo sapiens 215-242 21537437-4 2010 The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs (statins, fibrates, niacin and omega-3-fatty acids) on the circulating concentrations of leptin, adiponectin, tumor necrosis-factor-alpha (TNF-alpha), Retinol binding protein 4 (RBP4) and resistin. Fatty Acids, Omega-3 136-155 tumor necrosis factor Homo sapiens 244-253 21537437-4 2010 The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs (statins, fibrates, niacin and omega-3-fatty acids) on the circulating concentrations of leptin, adiponectin, tumor necrosis-factor-alpha (TNF-alpha), Retinol binding protein 4 (RBP4) and resistin. Fatty Acids, Omega-3 136-155 retinol binding protein 4 Homo sapiens 256-281 21537437-4 2010 The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs (statins, fibrates, niacin and omega-3-fatty acids) on the circulating concentrations of leptin, adiponectin, tumor necrosis-factor-alpha (TNF-alpha), Retinol binding protein 4 (RBP4) and resistin. Fatty Acids, Omega-3 136-155 retinol binding protein 4 Homo sapiens 283-287 21537437-6 2010 Studies that have examined the effects of statins, niacin and omega-3-fatty acids on TNF-alpha demonstrate that these agents have little effect on circulating TNF-alpha concentrations. Fatty Acids, Omega-3 62-81 tumor necrosis factor Homo sapiens 85-94 20856881-4 2010 There was an increase in n-3 fatty acids and a decrease in the n-6:n-3 ratio in liver mitochondria from the fat-1 compared to control mice. Fatty Acids, Omega-3 25-40 FAT atypical cadherin 1 Mus musculus 108-113 20813253-3 2010 (2010) demonstrate that the G protein-coupled receptor GPR120 is a receptor for omega-3 fatty acids on macrophages and fat cells. Fatty Acids, Omega-3 80-99 free fatty acid receptor 4 Homo sapiens 55-61 20813253-4 2010 Activation of GPR120 by omega-3 fatty acids inhibits multiple inflammation cascades in macrophages and reverses insulin resistance in obese mice. Fatty Acids, Omega-3 24-43 free fatty acid receptor 4 Mus musculus 14-20 20813258-3 2010 Stimulation of GPR120 with omega-3 FAs or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages. Fatty Acids, Omega-3 27-38 free fatty acid receptor 4 Mus musculus 15-21 20660502-1 2010 The omega-3 fatty acid ethanolamides, docosahexaenoyl ethanolamide (DHEA) and eicosapentaenoyl ethanolamide (EPEA), displayed greater anti-proliferative potency than their parent omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in LNCaP and PC3 prostate cancer cells. Fatty Acids, Omega-3 4-22 BTG anti-proliferation factor 2 Homo sapiens 273-276 20336774-3 2010 The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have neuroprotective effects in the aged brain and are endogenous ligands of RXR and PPAR. Fatty Acids, Omega-3 4-23 peroxisome proliferator activated receptor alpha Rattus norvegicus 168-172 20452984-3 2010 Here, we expressed two closely related plant FAD3 genes in yeast cells and found that their enzymes produced significantly different amounts of omega-3 fatty acids and that these differences correlated to differences in rates of protein turnover. Fatty Acids, Omega-3 144-163 omega-3 fatty acid desaturase, endoplasmic reticulum Nicotiana tabacum 45-49 20534879-7 2010 Duodenal FABP2 expression was correlated with (n-3) fatty acid (FA) intake in AA homozygotes (r = 0.49; P = 0.021). Fatty Acids, Omega-3 46-62 fatty acid binding protein 2 Homo sapiens 9-14 20004083-0 2010 Low omega-6/omega-3 polyunsaturated fatty acid ratios reduce hepatic C-reactive protein expression in apolipoprotein E-null mice. Fatty Acids, Omega-3 12-46 C-reactive protein, pentraxin-related Mus musculus 69-87 20004083-1 2010 OBJECTIVE: Expression characteristics of C-reactive protein (CRP) for the omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratios have not been evaluated in the well-qualified experimental atherosclerotic mouse model. Fatty Acids, Omega-3 82-116 C-reactive protein, pentraxin-related Mus musculus 41-59 20004083-1 2010 OBJECTIVE: Expression characteristics of C-reactive protein (CRP) for the omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratios have not been evaluated in the well-qualified experimental atherosclerotic mouse model. Fatty Acids, Omega-3 82-116 C-reactive protein, pentraxin-related Mus musculus 61-64 20004083-0 2010 Low omega-6/omega-3 polyunsaturated fatty acid ratios reduce hepatic C-reactive protein expression in apolipoprotein E-null mice. Fatty Acids, Omega-3 12-46 apolipoprotein E Mus musculus 102-118 20004083-2 2010 This work focused on characteristics of CRP expression in the liver of apolipoprotein E-null (apoE(-/-)) mice influenced by omega-6/omega-3 PUFA ratios. Fatty Acids, Omega-3 132-139 C-reactive protein, pentraxin-related Mus musculus 40-43 20004083-5 2010 RESULTS: As the dietary ratio of omega-6/omega-3 fatty acids ascended, so did the expression of hepatic and aortic CRP and hepatic IL-6 protein. Fatty Acids, Omega-3 41-60 C-reactive protein, pentraxin-related Mus musculus 115-118 19948371-5 2010 In the last few years, several studies have reported an association between single nucleotide polymorphisms (SNPs) in the two desaturase encoding genes (FADS1 and FADS2) and the concentration of omega-6 and omega-3 fatty acids. Fatty Acids, Omega-3 207-226 fatty acid desaturase 1 Homo sapiens 153-158 20004083-5 2010 RESULTS: As the dietary ratio of omega-6/omega-3 fatty acids ascended, so did the expression of hepatic and aortic CRP and hepatic IL-6 protein. Fatty Acids, Omega-3 41-60 interleukin 6 Mus musculus 131-135 20004083-9 2010 CONCLUSION: The results indicated that low ratios of omega-6/omega-3 PUFAs (1.28-9.98) downregulated the hepatic and aortic CRP expressions and reduced aortic en face lesions in apoE(-/-) mice compared with the high ratio of the omega-6/omega-3 PUFA diet. Fatty Acids, Omega-3 61-74 C-reactive protein, pentraxin-related Mus musculus 124-127 20004083-9 2010 CONCLUSION: The results indicated that low ratios of omega-6/omega-3 PUFAs (1.28-9.98) downregulated the hepatic and aortic CRP expressions and reduced aortic en face lesions in apoE(-/-) mice compared with the high ratio of the omega-6/omega-3 PUFA diet. Fatty Acids, Omega-3 61-73 C-reactive protein, pentraxin-related Mus musculus 124-127 20363734-7 2010 By contrast, the omega-3 fatty acid docosahexaenoic acid derivative, neuroprotectin D1 (NPD1), a potent activator of survival signaling, down-regulated oxidative stress-induced phosphorylation of Bcl-x(L) by increasing protein phosphatase activity. Fatty Acids, Omega-3 17-35 BCL2 like 1 Homo sapiens 196-201 20435334-6 2010 Multiple linear regression analyses revealed that age and omega-3 fatty acids in erythrocyte membranes (an index of marine food consumption) were positively associated with plasma AhR-mediated activity (p<0.001), whereas a negative association was noted with body fat mass (p=0.037). Fatty Acids, Omega-3 58-77 aryl hydrocarbon receptor Homo sapiens 180-183 20471368-0 2010 Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Fatty Acids, Omega-3 17-36 free fatty acid receptor 4 Homo sapiens 157-163 20471368-5 2010 Using a clonal HEK293 cell model, we examined agonist-mediated phosphorylation of GPR120-S and GPR120-L with the omega-3 fatty acids alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA). Fatty Acids, Omega-3 113-132 free fatty acid receptor 4 Homo sapiens 82-88 20471368-5 2010 Using a clonal HEK293 cell model, we examined agonist-mediated phosphorylation of GPR120-S and GPR120-L with the omega-3 fatty acids alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA). Fatty Acids, Omega-3 113-132 free fatty acid receptor 4 Homo sapiens 95-101 20148912-13 2010 Fish oil supplementation affects Th1 and Th2 immune responses conversely; significant consumption of n-3 fatty acids occurs during Th2-driven inflammation. Fatty Acids, Omega-3 101-116 heart and neural crest derivatives expressed 2 Mus musculus 131-134 20148912-14 2010 The latter observation may explain the association between Th2-mediated inflammation and low serum levels of n-3 fatty acids. Fatty Acids, Omega-3 109-124 heart and neural crest derivatives expressed 2 Mus musculus 59-62 19948371-5 2010 In the last few years, several studies have reported an association between single nucleotide polymorphisms (SNPs) in the two desaturase encoding genes (FADS1 and FADS2) and the concentration of omega-6 and omega-3 fatty acids. Fatty Acids, Omega-3 207-226 fatty acid desaturase 2 Homo sapiens 163-168 20194532-6 2010 The 18R- and 17R-resolvins putatively involved in resolution of inflammation are reportedly formed via aspirin-acetylated PGHS-2 from eicosapentaenoic acid and docosahexaenoic acid, respectively, so we also characterized the oxygenation of these omega-3 fatty acids by aspirin-treated huPGHS-2. Fatty Acids, Omega-3 246-265 prostaglandin-endoperoxide synthase 2 Homo sapiens 122-128 22435614-0 2010 Omega-3 but not omega-6 unsaturated fatty acids inhibit the cancer-specific ENOX2 of the HeLa cell surface with no effect on the constitutive ENOX1. Fatty Acids, Omega-3 0-7 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 76-81 22435614-8 2010 In experiments with surface NOX proteins released from HeLa cells, spectrophotometric measurements of the oxidation of NADH revealed inhibition of the cancer-specific ENOX2 activity by CLA and the omega-3 fatty acids, eicosapentaenoic, docosahexaenoic, and alpha-linolenic acids. Fatty Acids, Omega-3 197-216 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 167-172 22435614-11 2010 The findings indicate the possibility that a direct effect of CLA and omega-3 fatty acids on ENOX2 may be responsible for the potent activity of CLA and omega-3 fatty acids in cancer prevention and therapy. Fatty Acids, Omega-3 70-89 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 93-98 22435614-11 2010 The findings indicate the possibility that a direct effect of CLA and omega-3 fatty acids on ENOX2 may be responsible for the potent activity of CLA and omega-3 fatty acids in cancer prevention and therapy. Fatty Acids, Omega-3 153-172 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 93-98 20494167-5 2010 As expected, both fish oil and flaxseed supplementation increased the content of n-3 polyunsaturated fatty acids in milk fat. Fatty Acids, Omega-3 81-112 Weaning weight-maternal milk Bos taurus 116-120 20487553-6 2010 These PUFAs, in particular the highly unsaturated n-3 fatty acids change the gene expression of PPARa and SREBP, suppress the expression of mRNAs encoding key metabolic enzymes and hereby suppress hepatic lipogenesis and triglyceride synthesis, as well as secretion and accumulation in tissues. Fatty Acids, Omega-3 50-65 peroxisome proliferator activated receptor alpha Homo sapiens 96-101 20436486-0 2010 Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids. Fatty Acids, Omega-3 60-79 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 20233652-6 2010 Exposure to n-3 fatty acids enhances synaptic plasticity by increasing long-term potentiation and synaptic protein expression to increase the dendritic spine density, number of c-Fos-positive neurons and neurogenesis in the hippocampus for learning memory processing. Fatty Acids, Omega-3 12-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 177-182 22444129-3 2010 The diet enriched with n-3 polyunsaturated fatty acids (PUFAs) significantly inhibited SCD protein expression in muscle and subcutaneous adipose tissue, and reduced the Delta6d expression in muscle. Fatty Acids, Omega-3 23-54 stearoyl-CoA desaturase Bos taurus 87-90 22444129-3 2010 The diet enriched with n-3 polyunsaturated fatty acids (PUFAs) significantly inhibited SCD protein expression in muscle and subcutaneous adipose tissue, and reduced the Delta6d expression in muscle. Fatty Acids, Omega-3 23-54 fatty acid desaturase 2 Bos taurus 169-176 19874203-0 2010 Capacity of omega-3 fatty acids or eicosapentaenoic acid to counteract weightlessness-induced bone loss by inhibiting NF-kappaB activation: from cells to bed rest to astronauts. Fatty Acids, Omega-3 12-31 nuclear factor kappa B subunit 1 Homo sapiens 118-127 19998382-0 2010 Increased plasma n-3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China. Fatty Acids, Omega-3 17-47 insulin Homo sapiens 76-83 20639712-9 2010 The inflammatory biomarkers, erythrocyte sedimentation rate, and interleukin-8 decreased after supplementation with n-3 FA and erythrocyte sedimentation rate increased after supplementation with n-6 FA. Fatty Acids, Omega-3 116-122 C-X-C motif chemokine ligand 8 Homo sapiens 65-78 19998382-1 2010 Increased tissue n-3 polyunsaturated fatty acid (PUFA) is associated with improved insulin sensitivity in type 2 diabetes. Fatty Acids, Omega-3 17-47 insulin Homo sapiens 83-90 20177777-1 2010 Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). Fatty Acids, Omega-3 50-81 FAT atypical cadherin 1 Mus musculus 0-5 20042400-1 2010 BACKGROUND: We assumed that n-3 polyunsaturated fatty acid (n-3 PUFA) would attenuate the tissue dyslipidemic condition through suppression of sterol regulatory element-binding protein (SREBP-1) in the kidney and would prevent renal progression in diabetic animals. Fatty Acids, Omega-3 28-58 sterol regulatory element binding transcription factor 1 Mus musculus 186-193 20042400-1 2010 BACKGROUND: We assumed that n-3 polyunsaturated fatty acid (n-3 PUFA) would attenuate the tissue dyslipidemic condition through suppression of sterol regulatory element-binding protein (SREBP-1) in the kidney and would prevent renal progression in diabetic animals. Fatty Acids, Omega-3 60-68 sterol regulatory element binding transcription factor 1 Mus musculus 186-193 20396634-7 2010 However, these trials produced intriguing data suggesting that the beneficial effects of omega-3 fatty acid supplementation may depend on the stage of disease, other dietary mediators, and apolipoprotein E status. Fatty Acids, Omega-3 89-107 apolipoprotein E Homo sapiens 189-205 22444044-1 2010 The objective of our study was to determine the antioxidative potential of a plant extract (PE) mixture composed of carvacrol, capsicum oleoresin and cinnamaldehyde against high n-3 polyunsaturated fatty acid (PUFA)-induced oxidative stress in young pigs. Fatty Acids, Omega-3 178-208 Polyunsaturated fatty acid percentage Sus scrofa 210-214 20097190-6 2010 RESULTS: Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Fatty Acids, Omega-3 65-80 interleukin 6 Homo sapiens 117-121 20097190-6 2010 RESULTS: Multi-adjusted regression analyses revealed that plasma n-3 fatty acids were inversely associated with CRP, IL-6 and TNF-alpha; plasma n-6 fatty acids were inversely associated with CRP, IL-6 and fibrinogen; monounsaturated fatty acids were inversely associated with CRP and IL-6 (all p-values<0.05). Fatty Acids, Omega-3 65-80 tumor necrosis factor Homo sapiens 126-135 19909377-0 2010 CD4(+) T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 124-155 CD4 molecule Homo sapiens 0-3 19937854-0 2010 PPARalpha L162V polymorphism alters the potential of n-3 fatty acids to increase lipoprotein lipase activity. Fatty Acids, Omega-3 53-68 peroxisome proliferator activated receptor alpha Homo sapiens 0-9 19937854-0 2010 PPARalpha L162V polymorphism alters the potential of n-3 fatty acids to increase lipoprotein lipase activity. Fatty Acids, Omega-3 53-68 lipoprotein lipase Homo sapiens 81-99 19937854-1 2010 Omega-3 fatty acids (FAs) may accelerate plasma triglyceride (TG) clearance by altering lipoprotein lipase (LPL) activity. Fatty Acids, Omega-3 0-19 lipoprotein lipase Homo sapiens 88-106 19937854-1 2010 Omega-3 fatty acids (FAs) may accelerate plasma triglyceride (TG) clearance by altering lipoprotein lipase (LPL) activity. Fatty Acids, Omega-3 0-19 lipoprotein lipase Homo sapiens 108-111 20189790-2 2010 Both pre-clinical and clinical studies have been conducted to determine whether fish oils containing the n-3 PUFAs docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can be used in the prevention and treatment of immunoglobulin A nephropathy (IgAN) and lupus nephritis. Fatty Acids, Omega-3 105-114 IGAN1 Homo sapiens 251-255 20028357-5 2010 RESULTS: High omega-3 PUFA decreased liver PON1 mRNA expression, serum PON1, and HCTLase activity by 23% (p < 0.01), 20% (p < 0.05), and 28% (p < 0.05), respectively compared to the low omega-3 PUFA group. Fatty Acids, Omega-3 14-26 paraoxonase 1 Rattus norvegicus 43-47 20028357-5 2010 RESULTS: High omega-3 PUFA decreased liver PON1 mRNA expression, serum PON1, and HCTLase activity by 23% (p < 0.01), 20% (p < 0.05), and 28% (p < 0.05), respectively compared to the low omega-3 PUFA group. Fatty Acids, Omega-3 14-26 paraoxonase 1 Rattus norvegicus 71-75 20010096-7 2010 SUMMARY: In-vitro and animal studies show that n-3 PUFAs, cholesterol, and gangliosides modulate the structure and composition of lipid rafts, potentially influencing a wide range of biological processes, including immune function, neuronal signaling, cancer cell growth, entry of pathogens through the gut barrier, and insulin resistance in metabolic disorders. Fatty Acids, Omega-3 47-56 insulin Homo sapiens 320-327 19410444-6 2010 Moreover, omega-3 deprivation influenced antiapoptotic cell response after OGD, affecting GSK-3beta and ERK1/2, but not Akt, phosphorylation. Fatty Acids, Omega-3 10-17 glycogen synthase kinase 3 beta Rattus norvegicus 90-99 19410444-6 2010 Moreover, omega-3 deprivation influenced antiapoptotic cell response after OGD, affecting GSK-3beta and ERK1/2, but not Akt, phosphorylation. Fatty Acids, Omega-3 10-17 mitogen activated protein kinase 3 Rattus norvegicus 104-110 20028357-2 2010 Chronic alcohol (ETOH) and high omega-3 polyunsaturated fatty acids (omega-3 PUFA) consumption may affect PON1 status presumably via reactive oxygen species by depleting liver glutathione (GSH), whereas betaine may counter their effects. Fatty Acids, Omega-3 32-67 paraoxonase 1 Rattus norvegicus 106-110 20028357-2 2010 Chronic alcohol (ETOH) and high omega-3 polyunsaturated fatty acids (omega-3 PUFA) consumption may affect PON1 status presumably via reactive oxygen species by depleting liver glutathione (GSH), whereas betaine may counter their effects. Fatty Acids, Omega-3 69-81 paraoxonase 1 Rattus norvegicus 106-110 19909377-2 2010 Here, we showed that CD4(+) T-cell activation is dependent on changes in membrane n-3 polyunsaturated fatty acids (PUFAs) and is dynamically regulated by the type of signals provided by dendritic cells (DCs). Fatty Acids, Omega-3 82-113 CD4 molecule Homo sapiens 21-24 20196965-1 2010 Some evidence suggests that long-chain marine n-3 polyunsaturated fatty acids (n-3 PUFA) may increase production of vasodilatory nitric oxide from vascular endothelium. Fatty Acids, Omega-3 46-77 pumilio RNA binding family member 3 Homo sapiens 83-87 20196966-2 2010 In the SHOT study supplementation with 3.4 g/day of highly concentrated n-3 PUFA for 1 year significantly reduced the occlusion rate of venous aortocoronary bypass grafts, and this effect correlated significantly to the change in serum levels of n-3 fatty acids. Fatty Acids, Omega-3 246-261 pumilio RNA binding family member 3 Homo sapiens 76-80 19933995-2 2010 RESEARCH DESIGN AND METHODS: We developed an mfat-1 transgenic mouse model in which endogenous production of n-3 PUFAs was achieved through overexpressing a C. elegans n-3 fatty acid desaturase gene, mfat-1. Fatty Acids, Omega-3 109-118 M-line adipose tissue, general adiposity 1 Mus musculus 45-51 19573959-7 2010 Highest intake terciles of animal protein, refined carbohydrates, saturated fat, n-6 fatty acids and alcohol were associated with higher NF-kappaB, apoptosis and histological aggressiveness (p<0.01); the opposite tissue characteristics were associated with highest intake terciles of n-3 fatty acids, fibre, vitamin E, flavonoids, isoflavones, beta-carotene and selenium (p<0.002). Fatty Acids, Omega-3 66-79 nuclear factor kappa B subunit 1 Homo sapiens 137-146 19573959-8 2010 Additionally, higher n-6:n-3 fatty acids ratio (median 26:1) was associated with higher NF-kappaB (p<0.006) and apoptosis (p<0.01), and more aggressive histology (p<0.01). Fatty Acids, Omega-3 25-40 nuclear factor kappa B subunit 1 Homo sapiens 88-97 19573959-9 2010 Conversely, lower n-6:n-3 fatty acids ratio (median 6:1) was associated with lower NF-kappaB (p<0.002) and apoptosis (p<0.002), and less aggressive histology (p<0.002). Fatty Acids, Omega-3 22-37 nuclear factor kappa B subunit 1 Homo sapiens 83-92 19933995-2 2010 RESEARCH DESIGN AND METHODS: We developed an mfat-1 transgenic mouse model in which endogenous production of n-3 PUFAs was achieved through overexpressing a C. elegans n-3 fatty acid desaturase gene, mfat-1. Fatty Acids, Omega-3 109-118 M-line adipose tissue, general adiposity 1 Mus musculus 200-206 22254013-2 2010 There is increasing awareness of the importance of nutrition, particularly omega-3 polyunsaturated fatty acids (n-3 PUFA), for optimal brain development and function. Fatty Acids, Omega-3 75-110 pumilio RNA binding family member 3 Homo sapiens 116-120 20053136-0 2010 Transgenic mice enriched in omega-3 fatty acids are more susceptible to pulmonary tuberculosis: impaired resistance to tuberculosis in fat-1 mice. Fatty Acids, Omega-3 28-47 FAT atypical cadherin 1 Mus musculus 135-140 20155656-5 2010 Treatment strategies for reducing NF-kappaB are to reduce intraocular pressure as well as therapies with statins, omega-3-fatty acids and alpha-lipoic acid. Fatty Acids, Omega-3 114-133 nuclear factor kappa B subunit 1 Homo sapiens 34-43 19932682-4 2010 Docosahexaenoic acid (DHA), an omega-3 fatty acid, is known to inhibit IFNgamma signaling in inflammatory cells. Fatty Acids, Omega-3 31-49 interferon gamma Homo sapiens 71-79 21147711-0 2010 Association of interleukin-6 gene -572 C > G polymorphism with dietary intake of n-3 fatty acids on plasma HDL-c level in Chinese male adults. Fatty Acids, Omega-3 84-99 interleukin 6 Homo sapiens 15-28 20059901-3 2010 In utilizing SDA-enhanced soybean oil (SBO) derived from genetically modified soybeans, our objectives were to examine the potential to increase the n-3 fatty acid content of milk fat and to determine the efficiency of SDA uptake from the digestive tract and transfer to milk fat. Fatty Acids, Omega-3 149-163 Weaning weight-maternal milk Bos taurus 175-179 22952485-0 2010 Effect of Early Intervention with Omega-3 on Insulin Resistance in Patients Initiated on Olanzapine with either Sodium Valproate or Lithium: A randomized, Double-blind, Placebo-Controlled Trial. Fatty Acids, Omega-3 34-41 insulin Homo sapiens 45-52 22952485-8 2010 However, trends toward decreasing both fasting insulin levels (p=0.06) and HOMA-IR (p=0.07) were noted in the group receiving omega-3. Fatty Acids, Omega-3 126-133 insulin Homo sapiens 47-54 22952485-11 2010 However, trends toward a decrease in insulin levels (p=0.06) and HOMA-IR (p=0.07) observed in patients receiving omega-3 suggest a possible beneficial role of this supplement in this population and, therefore, warrant further evaluation. Fatty Acids, Omega-3 113-120 insulin Homo sapiens 37-44 21504136-1 2010 The effect of supplementation with the omega 3 polyunsaturated fatty acid (n3 PUFA) docosahexaenoic acid (DHA) on membrane composition and amyloid-beta1-42 (Abeta42) secretion was studied in human amyloid-beta protein precursor-transfected Chinese Hamster Ovary (CHO) cells. Fatty Acids, Omega-3 39-73 pumilio RNA binding family member 3 Homo sapiens 78-82 20059901-0 2010 Hot topic: Enhancing omega-3 fatty acids in milk fat of dairy cows by using stearidonic acid-enriched soybean oil from genetically modified soybeans. Fatty Acids, Omega-3 21-40 Weaning weight-maternal milk Bos taurus 44-48 20059901-9 2010 The SDA-abo treatment increased n-3 fatty acids to 3.9% of total milk fatty acids, a value more than 5-fold greater than that for the control. Fatty Acids, Omega-3 32-47 Weaning weight-maternal milk Bos taurus 65-69 20059901-13 2010 Overall, results demonstrate the potential to use SDA-enhanced SBO from genetically modified soybeans combined with proper ruminal protection to achieve impressive increases in the milk fat content of SDA and other n-3 fatty acids that are beneficial for human health. Fatty Acids, Omega-3 215-230 Weaning weight-maternal milk Bos taurus 181-185 19699314-0 2009 Suppression of VLDL secretion by cultured hepatocytes incubated with chylomicron remnants enriched in n-3 polyunsaturated fatty acids is regulated by hepatic nuclear factor-4alpha. Fatty Acids, Omega-3 102-133 hepatocyte nuclear factor 4, alpha Rattus norvegicus 150-179 19846544-0 2009 Effect of a dietary intervention and n-3 fatty acid supplementation on measures of serum lipid and insulin sensitivity in persons with HIV. Fatty Acids, Omega-3 37-51 insulin Homo sapiens 99-106 19545870-5 2009 Of the available options, adding either a niacin, fibrate or omega-3 fatty acids provides greater opportunity to achieve non-HDL-C and apoB targets, given complementary profiles of lipid-modifying activity and supported by evidence from clinical studies. Fatty Acids, Omega-3 61-80 apolipoprotein B Homo sapiens 135-139 20042103-5 2009 In this context, transgenic fat-1 mouse that is designed to convert n-6 to n-3 fatty acids could form an ideal model to study the altered metabolism of essential fatty acids in the above mentioned conditions. Fatty Acids, Omega-3 75-90 FAT atypical cadherin 1 Mus musculus 28-33 19716432-6 2009 N-3 fatty acids also effectively prevented insulin induction of the downstream lipogenic enzyme targets fatty acid synthase (FAS) and acetyl carboxyl coenzyme acetyltransferase-1 (ACC-1), and reduced de novo lipogenesis. Fatty Acids, Omega-3 0-15 fatty acid synthase Rattus norvegicus 125-128 19716432-0 2009 N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha. Fatty Acids, Omega-3 0-31 sterol regulatory element binding transcription factor 1 Rattus norvegicus 57-65 19716432-6 2009 N-3 fatty acids also effectively prevented insulin induction of the downstream lipogenic enzyme targets fatty acid synthase (FAS) and acetyl carboxyl coenzyme acetyltransferase-1 (ACC-1), and reduced de novo lipogenesis. Fatty Acids, Omega-3 0-15 acetyl-CoA carboxylase alpha Rattus norvegicus 134-178 19716432-6 2009 N-3 fatty acids also effectively prevented insulin induction of the downstream lipogenic enzyme targets fatty acid synthase (FAS) and acetyl carboxyl coenzyme acetyltransferase-1 (ACC-1), and reduced de novo lipogenesis. Fatty Acids, Omega-3 0-15 acetyl-CoA carboxylase alpha Rattus norvegicus 180-185 19716432-0 2009 N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha. Fatty Acids, Omega-3 0-31 nuclear receptor subfamily 1, group H, member 3 Rattus norvegicus 121-129 19716432-6 2009 N-3 fatty acids also effectively prevented insulin induction of the downstream lipogenic enzyme targets fatty acid synthase (FAS) and acetyl carboxyl coenzyme acetyltransferase-1 (ACC-1), and reduced de novo lipogenesis. Fatty Acids, Omega-3 0-15 fatty acid synthase Rattus norvegicus 104-123 19595382-0 2009 Serum levels of interleukin-18 are reduced by diet and n-3 fatty acid intervention in elderly high-risk men. Fatty Acids, Omega-3 55-69 interleukin 18 Homo sapiens 16-30 20029544-0 2009 Omega-3 fatty acids and atorvastatin affect connexin 43 expression in the aorta of hereditary hypertriglyceridemic rats. Fatty Acids, Omega-3 0-19 gap junction protein, alpha 1 Rattus norvegicus 44-55 19625064-2 2009 Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied. Fatty Acids, Omega-3 130-160 interleukin 6 Homo sapiens 26-39 19625064-2 2009 Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied. Fatty Acids, Omega-3 130-160 C-reactive protein Homo sapiens 71-74 19632286-0 2009 Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model. Fatty Acids, Omega-3 102-121 brain derived neurotrophic factor Mus musculus 14-47 19648503-0 2009 Chia (Salvia hispanica L.) seed as an n-3 fatty acid source for finishing pigs: effects on fatty acid composition and fat stability of the meat and internal fat, growth performance, and meat sensory characteristics. Fatty Acids, Omega-3 38-52 chitinase acidic Sus scrofa 0-4 19561360-4 2009 In this study, we observed that docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, diminished, in a dose-dependent manner, the capacity of Treg cells to inhibit the CD4(+)CD25(-) effector T-cell proliferation. Fatty Acids, Omega-3 63-93 CD4 molecule Homo sapiens 177-180 19595382-2 2009 Mediterranean-like diet and very long chain omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation have been reported to reduce the risk of cardiovascular mortality and morbidity, but the mechanisms are not fully clarified. Fatty Acids, Omega-3 44-78 pumilio RNA binding family member 3 Homo sapiens 84-88 20716918-2 2009 In this study, we investigated the synergistic anti-inflammatory and anti-oxidative capacity of n-3 FA and CR using Fat-1 transgenic mice (Fat-1) that are capable of converting n-6 FA to n-3 FA endogenously. Fatty Acids, Omega-3 187-193 FAT atypical cadherin 1 Mus musculus 139-144 19352379-0 2009 An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals. Fatty Acids, Omega-3 39-54 C-reactive protein Homo sapiens 59-77 19394939-2 2009 N-3 polyunsaturated fatty acids (n-3 PUFA) may have antioxidant and anti-inflammatory properties that are beneficial for cardiovascular and metabolic health. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 37-41 19828088-0 2009 Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men. Fatty Acids, Omega-3 7-21 apolipoprotein E Homo sapiens 79-83 19828088-0 2009 Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men. Fatty Acids, Omega-3 37-51 apolipoprotein E Homo sapiens 79-83 19568921-6 2009 A significant IL-10 increase was associated with the administration of omega-3 FAs (p = 0.04, vs omega-6 FAs group). Fatty Acids, Omega-3 71-82 interleukin 10 Homo sapiens 14-19 19568921-10 2009 In conclusion, omega-3 FAs supplemented PN can elevate the IL-10 level and HLA-DR expression in SAP patients. Fatty Acids, Omega-3 15-26 interleukin 10 Homo sapiens 59-64 19814866-6 2009 The aim of this study was to investigate and compare the potential effects of peroxisome proliferator-activated receptor (PPAR)-alpha agonists fenofibrate and n-3 polyunsaturated fatty acids (PUFAs) in modulation of AMPK-alpha1 activity in liver and skeletal muscle of high-fat diet fed rats. Fatty Acids, Omega-3 159-190 protein kinase AMP-activated catalytic subunit alpha 1 Rattus norvegicus 216-227 19648648-6 2009 However, docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, inhibited LPS- or lauric acid-induced dimerization and recruitment of TLR4 into lipid raft fractions. Fatty Acids, Omega-3 40-70 toll like receptor 4 Homo sapiens 142-146 19910654-1 2009 The purpose of this study was to test the influence of 2.4 g/d fish oil n-3 polyunsaturated fatty acids (n-3 PUFA) over 6 wk on exercise performance, inflammation, and immune measures in 23 trained cyclists before and after a 3-d period of intense exercise. Fatty Acids, Omega-3 72-103 pumilio RNA binding family member 3 Homo sapiens 109-113 19422375-1 2009 Evidence from observational studies, prospective cohort studies and randomized clinical intervention studies indicate that moderate doses of long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) significantly decrease risk of fatal coronary heart disease (CHD). Fatty Acids, Omega-3 152-183 pumilio RNA binding family member 3 Homo sapiens 192-196 19585164-0 2009 Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARalpha L162V polymorphism. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Homo sapiens 89-98 19501157-0 2009 Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation. Fatty Acids, Omega-3 27-45 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 157-166 19585164-1 2009 Omega-3 fatty acids (FAs) are natural ligands of the peroxisome proliferator-activated receptor-alpha (PPARalpha), a nuclear receptor that modulates expression levels of genes involved in lipid metabolism. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Homo sapiens 53-101 19585164-7 2009 Consequently, individuals carrying the PPARalpha-V162 allele may demonstrate inferior improvements in their lipid profile due to alterations in gene expression rates in response to omega-3 FA supplementation. Fatty Acids, Omega-3 181-191 peroxisome proliferator activated receptor alpha Homo sapiens 39-48 19585164-1 2009 Omega-3 fatty acids (FAs) are natural ligands of the peroxisome proliferator-activated receptor-alpha (PPARalpha), a nuclear receptor that modulates expression levels of genes involved in lipid metabolism. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Homo sapiens 103-112 19917185-0 2009 The association between n-3 fatty acids in erythrocyte membranes and insulin resistance: the Inuit Health in Transition Study. Fatty Acids, Omega-3 24-39 insulin Homo sapiens 69-76 19917185-1 2009 OBJECTIVES: To examine the association between the content of n-3 fatty acids and insulin resistance in an Inuit population. Fatty Acids, Omega-3 62-77 insulin Homo sapiens 82-89 19917185-10 2009 CONCLUSIONS: Our findings suggest that some types of n-3 fatty acids may have a protective effect against insulin resistance. Fatty Acids, Omega-3 53-68 insulin Homo sapiens 106-113 19264893-1 2009 PURPOSE: Fat-1 mice can convert n-6 to n-3 fatty acids endogenously, resulting in the accumulation of n-3 fatty acids in major tissues. Fatty Acids, Omega-3 39-54 FAT atypical cadherin 1 Mus musculus 9-14 19826183-0 2009 Modulation of connexin-43 by omega-3 fatty acids in the aorta of old spontaneously hypertensive rats. Fatty Acids, Omega-3 29-48 gap junction protein, alpha 1 Rattus norvegicus 14-25 19264893-1 2009 PURPOSE: Fat-1 mice can convert n-6 to n-3 fatty acids endogenously, resulting in the accumulation of n-3 fatty acids in major tissues. Fatty Acids, Omega-3 102-117 FAT atypical cadherin 1 Mus musculus 9-14 19826183-2 2009 The aim of the study was to investigate the effect of omega-3 polyunsaturated fatty acids (30 mg/day for 2 months) on expression of Cx43 in the aorta of 1-year-old male spontaneously hypertensive rats (SHR). Fatty Acids, Omega-3 54-89 gap junction protein, alpha 1 Rattus norvegicus 132-136 19826183-7 2009 Omega-3 fatty acid diet increased Cx43 immunolabeling in endothelium and media of SHR comparing to untreated ones. Fatty Acids, Omega-3 0-18 gap junction protein, alpha 1 Rattus norvegicus 34-38 19723076-7 2009 Omega-3 fatty acids inhibited oxidative stress-induced cell death, DNA fragmentation, and induction of p53 and Bax of the cells. Fatty Acids, Omega-3 0-19 tumor protein p53 Homo sapiens 103-106 19664246-1 2009 N-3 Polyunsaturated fatty acids have been shown to have potential beneficial effects for chronic diseases including cancer, insulin resistance and cardiovascular disease. Fatty Acids, Omega-3 0-31 insulin Homo sapiens 124-131 19664246-4 2009 Thus, clarification of ALA"s involvement in health and disease is essential, as it is the principle n-3 polyunsaturated fatty acid consumed in the North American diet and intakes of EPA and DHA are typically very low. Fatty Acids, Omega-3 100-130 5'-aminolevulinate synthase 1 Homo sapiens 23-28 19608872-4 2009 Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Fatty Acids, Omega-3 48-62 chemokine (C-C motif) ligand 2 Mus musculus 0-4 19608872-4 2009 Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Fatty Acids, Omega-3 48-62 chemokine (C-X3-C motif) receptor 1 Mus musculus 10-16 19608872-4 2009 Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Fatty Acids, Omega-3 137-152 chemokine (C-C motif) ligand 2 Mus musculus 0-4 19608872-4 2009 Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Fatty Acids, Omega-3 137-152 chemokine (C-X3-C motif) receptor 1 Mus musculus 10-16 19608872-7 2009 We also measured lower ocular TNF-alpha and IL-6 transcript levels in the mice fed a diet of high n-3 fatty acids. Fatty Acids, Omega-3 98-113 interleukin 6 Mus musculus 44-48 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. Fatty Acids, Omega-3 14-33 interleukin 1 beta Homo sapiens 155-163 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. Fatty Acids, Omega-3 14-33 interleukin 6 Homo sapiens 165-169 19723085-6 2009 We found that omega-3 fatty acids, such as docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA), suppressed the expression of inflammatory cytokines (IL-1beta, IL-6) and inhibited the activation of transcription factor activator protein-1 in cerulein-stimulated pancreatic acinar cells. Fatty Acids, Omega-3 14-33 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 224-243 19723076-7 2009 Omega-3 fatty acids inhibited oxidative stress-induced cell death, DNA fragmentation, and induction of p53 and Bax of the cells. Fatty Acids, Omega-3 0-19 BCL2 associated X, apoptosis regulator Homo sapiens 111-114 19185299-5 2009 RESULTS: After multivariable adjustment, n-3 fatty acid levels (DHA+EPA) were inversely associated with CRP and IL-6. Fatty Acids, Omega-3 41-55 C-reactive protein Homo sapiens 104-107 19185299-5 2009 RESULTS: After multivariable adjustment, n-3 fatty acid levels (DHA+EPA) were inversely associated with CRP and IL-6. Fatty Acids, Omega-3 41-55 interleukin 6 Homo sapiens 112-116 19185299-6 2009 The inverse association of n-3 fatty acids with CRP and IL-6 was not modified by demographics, body-mass index, smoking, LDL-cholesterol, or statin use (p values for interaction>0.1). Fatty Acids, Omega-3 27-42 C-reactive protein Homo sapiens 48-51 19185299-6 2009 The inverse association of n-3 fatty acids with CRP and IL-6 was not modified by demographics, body-mass index, smoking, LDL-cholesterol, or statin use (p values for interaction>0.1). Fatty Acids, Omega-3 27-42 interleukin 6 Homo sapiens 56-60 19567784-0 2009 Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells. Fatty Acids, Omega-3 0-7 C-X-C motif chemokine receptor 4 Homo sapiens 50-55 19729862-7 2009 As the dietary ratio of n-6/n-3 fatty acids increased, so did mRNA levels of hepatic apoA-I, scavenger receptor B class-1 (SR-B1), LCAT, ATP binding cassette transporter A1 (ABCA1), ABCG1 and liver X receptor alpha (LXRalpha). Fatty Acids, Omega-3 28-43 apolipoprotein A-I Mus musculus 85-91 19605645-6 2009 The omega-3 fatty acid docosahexaenoic acid (DHA) similarly inhibited JNK and the phosphorylation of IRS-1 and tau in cultured hippocampal neurons. Fatty Acids, Omega-3 4-22 mitogen-activated protein kinase 8 Mus musculus 70-73 20141608-9 2009 In conclusion, we offer further insight into the mechanisms involved in preventing the BMD loss in Ovx mice by n-3 FA using a Fat-1 transgenic mouse model. Fatty Acids, Omega-3 111-117 FAT atypical cadherin 1 Mus musculus 126-131 19605645-6 2009 The omega-3 fatty acid docosahexaenoic acid (DHA) similarly inhibited JNK and the phosphorylation of IRS-1 and tau in cultured hippocampal neurons. Fatty Acids, Omega-3 4-22 insulin receptor substrate 1 Mus musculus 101-106 19567784-3 2009 Much is known of the beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) on cancer; however, the mechanisms behind these effects are unclear. Fatty Acids, Omega-3 43-78 pumilio RNA binding family member 3 Homo sapiens 84-88 19567784-4 2009 For this study, we investigated the effects of two n-3 PUFAs, docosahexaenoic acid and eicosapentaenoic acid, on CXCR4 expression and activity in the MDA-MB-231 breast cancer cell line. Fatty Acids, Omega-3 51-60 C-X-C motif chemokine receptor 4 Homo sapiens 113-118 18772894-0 2009 Effects of conjugated linoleic acid plus n-3 polyunsaturated fatty acids on insulin secretion and estimated insulin sensitivity in men. Fatty Acids, Omega-3 41-72 insulin Homo sapiens 76-83 19568414-15 2009 Together, these observations provide mechanistic roles of omega-3 fatty acids in slowing prostate cancer growth by altering omega-6/omega-3 ratios through diet and by promoting apoptosis and inhibiting proliferation in tumors by directly competing with omega-6 fatty acids for 15-LO-1 and COX-2 activities. Fatty Acids, Omega-3 58-77 prostaglandin-endoperoxide synthase 2 Mus musculus 289-294 19438228-0 2009 Increase of cholesterol oxidation and decrease of PUFA as a result of thermal processing and storage in eggs enriched with n-3 fatty acids. Fatty Acids, Omega-3 123-138 pumilio RNA binding family member 3 Homo sapiens 50-54 19601807-2 2009 Rvs are biosynthesized from omega-3 fatty acids eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) via cyclooxygenase-2/lipoxygenase (COX-2/LOX) pathways; Rvs are shown to dramatically reduce dermal inflammation, peritonitis, dendritic cell migration, and interleukin production. Fatty Acids, Omega-3 28-47 mitochondrially encoded cytochrome c oxidase II Homo sapiens 141-146 19211925-5 2009 Moreover, omega-3-PUFAs increased adiponectin, an anti-inflammatory and insulin-sensitizing adipokine, and induced AMPK phosphorylation, a fuel-sensing enzyme and a gatekeeper of the energy balance. Fatty Acids, Omega-3 10-23 adiponectin, C1Q and collagen domain containing Mus musculus 34-45 19211925-8 2009 Moreover, representative members of these lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin expression to a similar extent that of rosiglitazone, a member of the thiazolidinedione family of antidiabetic drugs. Fatty Acids, Omega-3 158-171 skull morphology 2 Mus musculus 75-94 19272447-2 2009 Nvarepsilon-(propanoyl)lysine (propionyllysine, or PRL) is formed from the reaction of the oxidized products of n-3 PUFAs and lysine. Fatty Acids, Omega-3 112-121 prolactin Homo sapiens 51-54 19480700-1 2009 BACKGROUND: Dietary n-3-polyunsaturated fatty acids (n-3-PUFA) have been shown to reduce body weight and fat mass in rodents as well as in humans in one small short-term study. Fatty Acids, Omega-3 20-51 pumilio RNA binding family member 3 Homo sapiens 57-61 19460632-8 2009 omega3 FAs increased the levels of anti-apoptotic proteins like Bcl-2 and Bcl-extra large (Bcl-x(L)), known to be repressed in hypothyroidism. Fatty Acids, Omega-3 0-10 BCL2, apoptosis regulator Rattus norvegicus 64-69 19460632-8 2009 omega3 FAs increased the levels of anti-apoptotic proteins like Bcl-2 and Bcl-extra large (Bcl-x(L)), known to be repressed in hypothyroidism. Fatty Acids, Omega-3 0-10 Bcl2-like 1 Rattus norvegicus 91-99 19416532-4 2009 This analysis identifies natural and synthetic retinoids, antipsychotic medications, Omega 3 fatty acids, and pyrethroid pesticides as potential environmental modulators of metabolic syndrome phenotypes through PPAR and adipocytokine signaling and organophosphate pesticides as potential environmental modulators of neuropsychiatric phenotypes. Fatty Acids, Omega-3 85-104 peroxisome proliferator activated receptor alpha Homo sapiens 211-215 19268879-0 2009 Effects of omega-3 fatty acids on components of the transforming growth factor beta-1 pathway: implication for dietary modification and prevention in ovarian cancer. Fatty Acids, Omega-3 11-30 transforming growth factor beta 1 Homo sapiens 52-85 19318492-11 2009 CONCLUSIONS: Dietary LC n-3 polyunsaturated fatty acids appear protective for aggressive prostate cancer, and this effect is modified by the COX-2 SNP rs4648310. Fatty Acids, Omega-3 24-55 prostaglandin-endoperoxide synthase 2 Homo sapiens 141-146 19201689-0 2009 n-3 fatty acids reduce arterial LDL-cholesterol delivery and arterial lipoprotein lipase levels and lipase distribution. Fatty Acids, Omega-3 0-15 lipoprotein lipase Homo sapiens 70-88 19201689-1 2009 OBJECTIVE: We previously reported that saturated fat (SAT)-enriched diets increase arterial cholesteryl ester (CE) deposition, especially from LDL-selective uptake (SU), and this was associated with increased arterial lipoprotein lipase (LpL). Fatty Acids, Omega-3 39-52 lipoprotein lipase Homo sapiens 218-236 19201689-1 2009 OBJECTIVE: We previously reported that saturated fat (SAT)-enriched diets increase arterial cholesteryl ester (CE) deposition, especially from LDL-selective uptake (SU), and this was associated with increased arterial lipoprotein lipase (LpL). Fatty Acids, Omega-3 39-52 lipoprotein lipase Homo sapiens 238-241 19201689-1 2009 OBJECTIVE: We previously reported that saturated fat (SAT)-enriched diets increase arterial cholesteryl ester (CE) deposition, especially from LDL-selective uptake (SU), and this was associated with increased arterial lipoprotein lipase (LpL). Fatty Acids, Omega-3 54-57 lipoprotein lipase Homo sapiens 218-236 19201689-1 2009 OBJECTIVE: We previously reported that saturated fat (SAT)-enriched diets increase arterial cholesteryl ester (CE) deposition, especially from LDL-selective uptake (SU), and this was associated with increased arterial lipoprotein lipase (LpL). Fatty Acids, Omega-3 54-57 lipoprotein lipase Homo sapiens 238-241 19295455-10 2009 CONCLUSIONS: Parenteral therapy with n-3 fatty acids decreased histopathologic severity in ANP by early inhibition of prostaglandin (E2 and F1alpha) synthesis and reduction of lipid peroxidation. Fatty Acids, Omega-3 37-52 dihydrolipoamide S-succinyltransferase Rattus norvegicus 133-147 19088251-0 2009 Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids. Fatty Acids, Omega-3 80-99 adiponectin, C1Q and collagen domain containing Rattus norvegicus 0-11 20048483-6 2009 Lipid-modifying agents such as niacin, omega-3 fatty acids, and statins also decrease fasting and postprandial triglycerides by increasing lipoprotein lipase (LPL) activity and/or decreasing VLDL synthesis. Fatty Acids, Omega-3 39-58 lipoprotein lipase Homo sapiens 139-157 20048483-6 2009 Lipid-modifying agents such as niacin, omega-3 fatty acids, and statins also decrease fasting and postprandial triglycerides by increasing lipoprotein lipase (LPL) activity and/or decreasing VLDL synthesis. Fatty Acids, Omega-3 39-58 lipoprotein lipase Homo sapiens 159-162 19136374-0 2009 Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. Fatty Acids, Omega-3 69-84 FAT atypical cadherin 1 Mus musculus 32-37 19136374-4 2009 OBJECTIVES: To determine whether the ability of fat-1 mice to endogenously convert n-6 to n-3 FA, and thus generate an increased ratio of n-3 to n-6 FA, impacts experimental ALI. Fatty Acids, Omega-3 90-96 FAT atypical cadherin 1 Mus musculus 48-53 19088251-0 2009 Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids. Fatty Acids, Omega-3 80-99 peroxisome proliferator-activated receptor gamma Rattus norvegicus 44-53 19358934-0 2009 Dietary omega-3 fatty acids differentially influence ova release and ovarian cyclooxygenase-1 and cyclooxygenase-2 expression in rats. Fatty Acids, Omega-3 8-27 prostaglandin-endoperoxide synthase 1 Rattus norvegicus 77-93 19202385-0 2009 Prevention of insulin resistance by n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 36-67 insulin Homo sapiens 14-21 19202385-1 2009 PURPOSE OF REVIEW: Review results from recent human and animal studies regarding the effects of n-3 polyunsaturated fatty acid (PUFA) in the prevention of insulin resistance. Fatty Acids, Omega-3 96-126 insulin Homo sapiens 155-162 19358934-0 2009 Dietary omega-3 fatty acids differentially influence ova release and ovarian cyclooxygenase-1 and cyclooxygenase-2 expression in rats. Fatty Acids, Omega-3 8-27 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 98-114 19171471-0 2009 Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. Fatty Acids, Omega-3 0-18 matrix metallopeptidase 9 Homo sapiens 45-71 18631416-9 2009 In overweight women only (n 366), a high pre-pregnancy n-3 fatty acid intake (% PUFA) was positively associated with the newborn"s birth weight (P=0.01), head, arm and wrist circumferences and sum of skinfolds (P<0.04). Fatty Acids, Omega-3 55-69 pumilio RNA binding family member 3 Homo sapiens 80-84 18631416-12 2009 We concluded that a high pre-pregnancy n-3 fatty acid:PUFA ratio may sustain fetal growth in overweight women. Fatty Acids, Omega-3 39-53 pumilio RNA binding family member 3 Homo sapiens 54-58 19030909-0 2009 The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults. Fatty Acids, Omega-3 21-36 phospholipase A2 group VII Homo sapiens 84-91 19030909-3 2009 AIM OF THE STUDY: The aim of the trial was to study the effect of marine n-3 polyunsaturated fatty acids (PUFA) on plasma Lp-PLA(2) levels in healthy subjects. Fatty Acids, Omega-3 73-104 phospholipase A2 group VII Homo sapiens 122-131 19171471-1 2009 OBJECTIVES: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Fatty Acids, Omega-3 64-83 matrix metallopeptidase 9 Homo sapiens 100-126 19171471-1 2009 OBJECTIVES: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Fatty Acids, Omega-3 64-83 matrix metallopeptidase 9 Homo sapiens 128-133 19171471-1 2009 OBJECTIVES: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Fatty Acids, Omega-3 85-95 matrix metallopeptidase 9 Homo sapiens 100-126 19171471-1 2009 OBJECTIVES: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Fatty Acids, Omega-3 85-95 matrix metallopeptidase 9 Homo sapiens 128-133 19171471-5 2009 RESULTS: Immune cell secretion of MMP-9 decreased by 58% after 3 months of omega-3 FA supplementation when compared with baseline levels (p<0.01). Fatty Acids, Omega-3 75-85 matrix metallopeptidase 9 Homo sapiens 34-39 19133114-0 2009 Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report. Fatty Acids, Omega-3 0-19 apolipoprotein B Homo sapiens 49-67 20029635-2 2009 Adipogenesis observed in the low n-3 fatty acid mice was accompanied by a 6-fold upregulation of stearyl-coenzyme A desaturase 1 (Scd1), whose activity is correlated to plasma triglyceride levels. Fatty Acids, Omega-3 33-47 stearoyl-Coenzyme A desaturase 1 Mus musculus 97-128 19786387-9 2009 As newborns primarily depend on placental transfer of omega-3 FA there is need to examine the omega-3 LC-PUFA concentration in infants of mother"s with low intakes of omega-3 FA. Fatty Acids, Omega-3 167-177 pumilio RNA binding family member 3 Homo sapiens 105-109 20029635-2 2009 Adipogenesis observed in the low n-3 fatty acid mice was accompanied by a 6-fold upregulation of stearyl-coenzyme A desaturase 1 (Scd1), whose activity is correlated to plasma triglyceride levels. Fatty Acids, Omega-3 33-47 stearoyl-Coenzyme A desaturase 1 Mus musculus 130-134 19776639-4 2009 Several studies in the last few years have revealed that single nucleotide polymorphisms (SNPs) in the 2 desaturase encoding genes (FADS1 and FADS2) are highly associated with the concentration of omega-6 and omega-3 fatty acids, showing that beside nutrition, genetic factors also play an important role in the regulation of LC-PUFAs. Fatty Acids, Omega-3 209-228 fatty acid desaturase 1 Homo sapiens 132-137 19468948-7 2009 We conclude that the beneficial effect of omega-3 fatty acid supplementation during endurance exercise may be due to the activation of the superoxide dismutase and catalase pathways. Fatty Acids, Omega-3 42-60 catalase Homo sapiens 164-172 18791145-0 2009 Effect of level and duration of dietary n-3 polyunsaturated fatty acid supplementation on the transcriptional regulation of Delta9-desaturase in muscle of beef cattle. Fatty Acids, Omega-3 40-70 stearoyl-CoA desaturase Bos taurus 124-141 19776639-4 2009 Several studies in the last few years have revealed that single nucleotide polymorphisms (SNPs) in the 2 desaturase encoding genes (FADS1 and FADS2) are highly associated with the concentration of omega-6 and omega-3 fatty acids, showing that beside nutrition, genetic factors also play an important role in the regulation of LC-PUFAs. Fatty Acids, Omega-3 209-228 fatty acid desaturase 2 Homo sapiens 142-147 19784597-4 2009 We recently identified propanoyl-lysine (propionyl-lysine, PRL) from the reaction of an n-3 FA and a lysine residue. Fatty Acids, Omega-3 88-94 prolactin Homo sapiens 59-62 19266045-0 2009 Differences in transcriptional activation by the two allelic (L162V Polymorphic) variants of PPARalpha after Omega-3 fatty acids treatment. Fatty Acids, Omega-3 109-128 peroxisome proliferator activated receptor alpha Homo sapiens 93-102 19266045-1 2009 Omega-3 fatty acids (FAs) have the potential to regulate gene expression via the peroxisome proliferator-activated receptor alpha (PPARalpha); therefore, genetic variations in this gene may impact its transcriptional activity on target genes. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Homo sapiens 81-129 19266045-1 2009 Omega-3 fatty acids (FAs) have the potential to regulate gene expression via the peroxisome proliferator-activated receptor alpha (PPARalpha); therefore, genetic variations in this gene may impact its transcriptional activity on target genes. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Homo sapiens 131-140 19138887-5 2009 Mice engineered to carry a fat-1 gene from Caenorhabditis elegans add a double bond into an unsaturated fatty acid hydrocarbon chain and convert n-6 to n-3 fatty acids. Fatty Acids, Omega-3 152-167 FAT atypical cadherin 1 Mus musculus 27-32 19266045-7 2009 In conclusion, both allelic variants of the PPARalpha L162V are activated by omega-3 FAs; however, the V162 allelic form displays a lower transcriptional activity than the wild-type variant. Fatty Acids, Omega-3 77-88 peroxisome proliferator activated receptor alpha Homo sapiens 44-53 19340699-7 2009 D5D expression was inversely correlated with EPA, DPA, DHA and total n-3 FA, and positively correlated with the ratio total n-6 FA/total n-3 FA at t = 0. Fatty Acids, Omega-3 69-75 fatty acid desaturase 1 Homo sapiens 0-3 18343384-0 2008 Dietary intake of n-3 polyunsaturated fatty acids is inversely associated with CRP levels, especially among male smokers. Fatty Acids, Omega-3 18-49 C-reactive protein Homo sapiens 79-82 17700648-10 2008 CONCLUSIONS: The findings suggest that PPARG polymorphism might affect the plasma proportion of eicosapentaenoic acid and modulate the associations of fish intake and marine n-3 fatty acids with glucose metabolism and fasting free fatty acids. Fatty Acids, Omega-3 174-189 peroxisome proliferator activated receptor gamma Homo sapiens 39-44 18977126-0 2008 fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cells. Fatty Acids, Omega-3 74-89 FAT atypical cadherin 1 Mus musculus 0-5 18977126-0 2008 fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cells. Fatty Acids, Omega-3 74-89 CD4 antigen Mus musculus 103-106 18343384-1 2008 OBJECTIVE: To examine whether dietary intake of n-3 polyunsaturated fatty acid (n-3PUFA) is associated with serum C-reactive protein (CRP) levels with regard to smoking status in the Japanese general population in a cross-sectional study. Fatty Acids, Omega-3 80-87 C-reactive protein Homo sapiens 114-132 18343384-1 2008 OBJECTIVE: To examine whether dietary intake of n-3 polyunsaturated fatty acid (n-3PUFA) is associated with serum C-reactive protein (CRP) levels with regard to smoking status in the Japanese general population in a cross-sectional study. Fatty Acids, Omega-3 80-87 C-reactive protein Homo sapiens 134-137 18977126-9 2008 We conclude that fat-1-containing CD4+ T-cells express a physiologically relevant, n-3 PUFA enriched, membrane fatty acid composition which is resistant to conventional cell culture-induced depletion. Fatty Acids, Omega-3 83-91 FAT atypical cadherin 1 Mus musculus 17-22 18977126-9 2008 We conclude that fat-1-containing CD4+ T-cells express a physiologically relevant, n-3 PUFA enriched, membrane fatty acid composition which is resistant to conventional cell culture-induced depletion. Fatty Acids, Omega-3 83-91 CD4 antigen Mus musculus 34-37 18343384-1 2008 OBJECTIVE: To examine whether dietary intake of n-3 polyunsaturated fatty acid (n-3PUFA) is associated with serum C-reactive protein (CRP) levels with regard to smoking status in the Japanese general population in a cross-sectional study. Fatty Acids, Omega-3 48-78 C-reactive protein Homo sapiens 114-132 18343384-1 2008 OBJECTIVE: To examine whether dietary intake of n-3 polyunsaturated fatty acid (n-3PUFA) is associated with serum C-reactive protein (CRP) levels with regard to smoking status in the Japanese general population in a cross-sectional study. Fatty Acids, Omega-3 48-78 C-reactive protein Homo sapiens 134-137 18941214-0 2008 n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation. Fatty Acids, Omega-3 0-31 CD4 antigen Mus musculus 134-137 18832028-0 2008 Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Fatty Acids, Omega-3 55-74 FAT atypical cadherin 1 Mus musculus 78-83 18973601-0 2008 Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice. Fatty Acids, Omega-3 67-97 interleukin 6 Mus musculus 14-27 19048591-5 2008 Alexopoulos and Donadio found that the progression of IgAN slowed down with the use of omega-3 fatty acids; Woo and Nakao used angiotensin inhibitors to obtain the same result, while Ballardie used immunosuppressors. Fatty Acids, Omega-3 87-106 IGAN1 Homo sapiens 54-58 18632990-0 2008 Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids. Fatty Acids, Omega-3 53-71 retinoid X receptor alpha Homo sapiens 122-125 18936223-4 2008 We determined if single nucleotide polymorphisms in FADS1 and FADS2 influence plasma phospholipid and erythrocyte ethanolamine phosphoglyceride (EPG) (n-6) and (n-3) fatty acids of women in pregnancy or their breast milk during lactation. Fatty Acids, Omega-3 160-177 fatty acid desaturase 1 Homo sapiens 52-57 18936223-4 2008 We determined if single nucleotide polymorphisms in FADS1 and FADS2 influence plasma phospholipid and erythrocyte ethanolamine phosphoglyceride (EPG) (n-6) and (n-3) fatty acids of women in pregnancy or their breast milk during lactation. Fatty Acids, Omega-3 160-177 fatty acid desaturase 2 Homo sapiens 62-67 18484673-0 2008 Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Fatty Acids, Omega-3 0-19 adiponectin, C1Q and collagen domain containing Mus musculus 69-80 18484673-14 2008 Adiponectin expression was significantly suppressed by induction of colitis, and aggravation of colitis after exposure to omega-3 fat may be due to a further decrease in the expression level of adiponectin. Fatty Acids, Omega-3 122-129 adiponectin, C1Q and collagen domain containing Mus musculus 0-11 18484673-14 2008 Adiponectin expression was significantly suppressed by induction of colitis, and aggravation of colitis after exposure to omega-3 fat may be due to a further decrease in the expression level of adiponectin. Fatty Acids, Omega-3 122-129 adiponectin, C1Q and collagen domain containing Mus musculus 194-205 18834249-4 2008 The purpose of the present study was to evaluate the effects of celecoxib and omega-3 fatty acid administration on the gingival tissue expression of MMP-8, -13, and -14, tissue inhibitor of MMP (TIMP)-1, and laminin (Ln)-5gamma2-chain in rat experimental periodontitis induced by Escherichia coli endotoxin (lipopolysaccharide [LPS]). Fatty Acids, Omega-3 78-96 matrix metallopeptidase 8 Rattus norvegicus 149-154 18834249-17 2008 CONCLUSIONS: Selective cyclooxygenase-2 inhibitor, prophylactic omega-3 fatty acid, and a combination of these two agents can inhibit gingival tissue MMP-8 expression. Fatty Acids, Omega-3 64-82 matrix metallopeptidase 8 Rattus norvegicus 150-155 18262557-9 2008 omega-3 FA pretreatment at 12 and 24 h also had less iNOS protein expression compared to omega-6 FA or media-only conditions. Fatty Acids, Omega-3 0-10 nitric oxide synthase 2 Homo sapiens 53-57 18803934-12 2008 These data suggest that omega-6 and omega-3 fatty acids can differentially modulate TNF-alpha-induced inflammatory stimuli and that caveolae and its fatty acid composition play a regulatory role during TNF-alpha-induced endothelial cell activation and inflammation. Fatty Acids, Omega-3 36-55 tumor necrosis factor Homo sapiens 84-93 18262557-10 2008 Tumor necrosis factor-alpha production was significantly decreased with omega-3 FA treatment compared to omega-6 FA treatment (P < 0.05) after 24 h LPS stimulation. Fatty Acids, Omega-3 72-82 tumor necrosis factor Homo sapiens 0-27 18638380-0 2008 The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation. Fatty Acids, Omega-3 4-22 tumor necrosis factor Mus musculus 86-120 18718737-7 2008 The formula also rich in slowly digested carbohydrate and monounsaturated and omega-3 fatty acids (SDC) produced significantly lower blood glucose and insulin responses and higher levels of GLP-1 in the presence of significantly lower insulin concentrations. Fatty Acids, Omega-3 78-97 glucagon Homo sapiens 190-195 18718737-7 2008 The formula also rich in slowly digested carbohydrate and monounsaturated and omega-3 fatty acids (SDC) produced significantly lower blood glucose and insulin responses and higher levels of GLP-1 in the presence of significantly lower insulin concentrations. Fatty Acids, Omega-3 78-97 insulin Homo sapiens 151-158 18679798-3 2008 Our aim was to assess whether the n-3 polyunsaturated fatty acid docosahexaenoic acid (DHA), known to inhibit the growth of several cancer cells mainly inducing apoptosis, may exert pro-apoptotic effect in lung cancer cells by modifying MKP-1 expression. Fatty Acids, Omega-3 34-64 dual specificity phosphatase 1 Homo sapiens 237-242 18205990-1 2008 In mammals, (n-3) PUFA and conjugated linoleic acids (CLA) act as activators of PPAR alpha and alter nuclear concentrations of sterol regulatory element-binding proteins (SREBP) in the liver, and thereby influence hepatic lipid catabolism and synthesis. Fatty Acids, Omega-3 12-22 peroxisome proliferator activated receptor alpha Gallus gallus 80-90 18573585-7 2008 However, the omega-3 fatty acids group showed significant improvement in ADAS-cog compared to the placebo group in participants with mild cognitive impairment (p=0.03), which was not observed in those with Alzheimer"s disease. Fatty Acids, Omega-3 13-32 alkylglycerone phosphate synthase Homo sapiens 73-77 18803934-3 2008 We hypothesize that omega-6 and omega-3 fatty acids can differentially modulate tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation and that functional plasma membrane microdomains called caveolae are required for endothelial cell activation. Fatty Acids, Omega-3 32-51 tumor necrosis factor Homo sapiens 80-107 18803934-3 2008 We hypothesize that omega-6 and omega-3 fatty acids can differentially modulate tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation and that functional plasma membrane microdomains called caveolae are required for endothelial cell activation. Fatty Acids, Omega-3 32-51 tumor necrosis factor Homo sapiens 109-118 18504706-1 2008 With regard to inflammatory processes, the main fatty acids of interest are the n-6 PUFA arachidonic acid (AA), which is the precursor of inflammatory eicosanoids like prostaglandin E(2) and leukotriene B(4), and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Fatty Acids, Omega-3 217-226 pumilio RNA binding family member 3 Homo sapiens 84-88 18491071-1 2008 AIMS/HYPOTHESIS: Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. Fatty Acids, Omega-3 68-99 pumilio RNA binding family member 3 Homo sapiens 108-112 18368490-6 2008 Individual administration of omega-3 fatty acids 12 mg/kg, black seed oil 50 mg/kg, and curcuminoids 50 mg/kg body weight orally daily for 3 weeks decreased MDA, gastrin, and NO, and normalized mucosal GSH but failed to affect serum pepsinogen level. Fatty Acids, Omega-3 29-48 gastrin Rattus norvegicus 162-169 18491071-1 2008 AIMS/HYPOTHESIS: Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. Fatty Acids, Omega-3 68-99 insulin Homo sapiens 122-129 18555833-2 2008 This diet is also an abundant source of n-3 polyunsaturated fatty acids (n-3 PUFA), selenium, and antioxidants, which might reduce cardiovascular risk. Fatty Acids, Omega-3 40-71 pumilio RNA binding family member 3 Homo sapiens 77-81 17855067-0 2008 Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta-intestinal intraepithelial lymphocytes. Fatty Acids, Omega-3 29-60 interleukin 15 Rattus norvegicus 75-80 17855067-0 2008 Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta-intestinal intraepithelial lymphocytes. Fatty Acids, Omega-3 29-60 CD8a molecule Rattus norvegicus 137-145 17855067-0 2008 Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta-intestinal intraepithelial lymphocytes. Fatty Acids, Omega-3 29-60 CD8b molecule Rattus norvegicus 146-153 18603066-7 2008 RESULTS: Four-hour pretreatment markedly reduced inflammatory endothelial release of interleukin 8 (2587 +/- 82 pg/mL control vs 208 +/- 3 pg/mL omega-3 pretreated, P < .01) and endothelial expression of intercellular adhesion molecule 1 (196.1 +/- 2.0 vs 71.9 +/- 0.6 mean channel fluorescence, P < .01) in response to endotoxin and tumor necrosis factor a. Neutrophil activation (CD11b and respiratory burst) was maintained, but pretreated neutrophils had shorter survival. Fatty Acids, Omega-3 145-152 C-X-C motif chemokine ligand 8 Homo sapiens 85-98 18508495-2 2008 Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-1, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Fatty Acids, Omega-3 81-87 interleukin 1 complex Mus musculus 238-242 18450755-0 2008 In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 67-98 syndecan 1 Homo sapiens 35-45 18450755-4 2008 The present study examined the regulation of syndecan 1 in prostate epithelial cells by n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 88-119 syndecan 1 Homo sapiens 45-55 18450755-10 2008 These findings indicate that syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma. Fatty Acids, Omega-3 59-74 syndecan 1 Homo sapiens 29-39 18450755-10 2008 These findings indicate that syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma. Fatty Acids, Omega-3 59-74 peroxisome proliferator activated receptor gamma Homo sapiens 114-123 18460914-4 2008 RECENT FINDINGS: Dietary n-3 polyunsaturated fatty acid regulates hepatic gene expression by targeting three major transcriptional regulatory networks: peroxisome proliferator-activated receptor alpha, sterol regulatory element binding protein-1 and the carbohydrate regulatory element binding protein/Max-like factor X heterodimer. Fatty Acids, Omega-3 25-55 peroxisome proliferator activated receptor alpha Homo sapiens 152-200 18460914-4 2008 RECENT FINDINGS: Dietary n-3 polyunsaturated fatty acid regulates hepatic gene expression by targeting three major transcriptional regulatory networks: peroxisome proliferator-activated receptor alpha, sterol regulatory element binding protein-1 and the carbohydrate regulatory element binding protein/Max-like factor X heterodimer. Fatty Acids, Omega-3 25-55 sterol regulatory element binding transcription factor 1 Homo sapiens 202-245 18460914-5 2008 22:6,n-3, the most prominent n-3 polyunsaturated fatty acid in tissues, is a weak activator of peroxisome proliferator-activated receptor alpha. Fatty Acids, Omega-3 29-59 peroxisome proliferator activated receptor alpha Homo sapiens 95-143 18469350-8 2008 Total microparticle tissue factor-procoagulant activity was also reduced in the n-3 fatty acid group compared to that in the placebo group. Fatty Acids, Omega-3 80-94 coagulation factor III, tissue factor Homo sapiens 20-33 18309477-2 2008 We aim to assess the relationship between omega-3 fatty acids (n-3 PUFA) and AF occurrence in post-myocardial infarction (MI) patients. Fatty Acids, Omega-3 42-61 pumilio RNA binding family member 3 Homo sapiens 67-71 18403593-10 2008 These results also suggest that the beneficial inhibitory effects of DHA on fibrinolytic/MMP activity are related in part to the effects of DHA on the expression of Notch pathway components, providing new insight into the mechanisms by which omega-3 fatty acids prevent cardiovascular diseases. Fatty Acids, Omega-3 242-261 notch receptor 1 Rattus norvegicus 165-170 18508495-2 2008 Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-1, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Fatty Acids, Omega-3 81-87 interleukin 6 Mus musculus 244-248 18508495-2 2008 Recent studies show that reduced calorie intake and supplementation of diet with n-3 FA delays the onset of autoimmune renal disease, primarily, due to increased antioxidant enzyme activities, decreased NF-kappaB activation and decreased IL-1, IL-6 and TNF-alpha mRNA expression in the kidney tissue. Fatty Acids, Omega-3 81-87 tumor necrosis factor Mus musculus 253-262 19083425-0 2008 Total n-3 polyunsaturated fatty acid intake is inversely associated with serum C-reactive protein in young Japanese women. Fatty Acids, Omega-3 6-36 C-reactive protein Homo sapiens 79-97 18356842-0 2008 Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin. Fatty Acids, Omega-3 41-59 adiponectin, C1Q and collagen domain containing Homo sapiens 92-103 19083425-7 2008 After adjustment for possible confounding factors including body mass index, a significant inverse association was seen between total n-3 polyunsaturated fatty acid intake and elevated CRP. Fatty Acids, Omega-3 134-164 C-reactive protein Homo sapiens 185-188 19083425-12 2008 In conclusion, total n-3 polyunsaturated fatty acid intake showed an independent inverse association with elevated serum CRP concentration in a group of young Japanese women. Fatty Acids, Omega-3 21-51 C-reactive protein Homo sapiens 121-124 18413760-0 2008 Peroxisome proliferator-activated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells. Fatty Acids, Omega-3 89-104 peroxisome proliferator activated receptor gamma Homo sapiens 0-48 18413760-0 2008 Peroxisome proliferator-activated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells. Fatty Acids, Omega-3 89-104 syndecan 1 Homo sapiens 75-85 18413760-1 2008 Diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFA) may protect against breast cancer but biochemical mechanisms are unclear. Fatty Acids, Omega-3 18-49 pumilio RNA binding family member 3 Homo sapiens 55-59 18413760-2 2008 Our studies showed that the n-3 fatty acid docosahexaenoic acid (DHA) up-regulated syndecan-1 (SDC-1) in human breast cancer cells, and we tested the hypothesis that DHA-mediated up-regulation of SDC-1 induces apoptosis. Fatty Acids, Omega-3 28-42 syndecan 1 Homo sapiens 83-93 18413760-2 2008 Our studies showed that the n-3 fatty acid docosahexaenoic acid (DHA) up-regulated syndecan-1 (SDC-1) in human breast cancer cells, and we tested the hypothesis that DHA-mediated up-regulation of SDC-1 induces apoptosis. Fatty Acids, Omega-3 28-42 syndecan 1 Homo sapiens 95-100 18067925-0 2008 Attenuation of iNOS in an LPS-stimulated macrophage model by omega-3 fatty acids is independent of COX-2 derived PGE2. Fatty Acids, Omega-3 61-80 nitric oxide synthase 2 Homo sapiens 15-19 18158339-0 2008 Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension. Fatty Acids, Omega-3 8-39 renin Homo sapiens 123-128 18155686-4 2008 We tested the hypothesis that mechanisms of PCB-induced endothelial cell activation and inflammation can be modified by different ratios of omega-6 to omega-3 fatty acids. Fatty Acids, Omega-3 151-170 pyruvate carboxylase Homo sapiens 44-47 18155686-10 2008 The present studies suggest that NF-kappaB is a critical player in the regulation of PCB-induced inflammatory markers as modulated by omega-6 and omega-3 fatty acids. Fatty Acids, Omega-3 146-165 nuclear factor kappa B subunit 1 Homo sapiens 33-42 18155686-10 2008 The present studies suggest that NF-kappaB is a critical player in the regulation of PCB-induced inflammatory markers as modulated by omega-6 and omega-3 fatty acids. Fatty Acids, Omega-3 146-165 pyruvate carboxylase Homo sapiens 85-88 18206980-6 2008 It ensued that 10muM of these two omega3 fatty acids decreased by more than 80% and 60%, respectively, the formation by CYP2C9 of AA-epoxidised derivatives. Fatty Acids, Omega-3 34-52 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 120-126 18206980-7 2008 These findings suggest that some physiological effects of omega3 fatty acids may be due to a shift in the generation of active epoxidised metabolites of AA through CYP-mediated catalysis. Fatty Acids, Omega-3 58-76 peptidylprolyl isomerase G Homo sapiens 164-167 18258624-0 2008 Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women. Fatty Acids, Omega-3 18-49 adiponectin, C1Q and collagen domain containing Homo sapiens 92-103 18258624-1 2008 BACKGROUND: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Fatty Acids, Omega-3 50-81 adiponectin, C1Q and collagen domain containing Homo sapiens 111-122 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 interleukin 1 beta Homo sapiens 68-86 17868330-3 2008 n-3 polyunsaturated fatty acids (PUFA), such as those found in fish oil (FO), are naturally occurring PPARalpha ligands which also suppress lipid synthesis. Fatty Acids, Omega-3 0-31 peroxisome proliferator activated receptor alpha Mus musculus 102-111 18155022-0 2008 Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid. Fatty Acids, Omega-3 55-85 potassium voltage-gated channel subfamily A member 5 Homo sapiens 34-39 18211635-2 2008 n-3 fatty acids are ligands for the peroxisome proliferator-activated receptor-gamma (PPARG), which has recently been implicated in the control of inflammation and possibly autoimmunity. Fatty Acids, Omega-3 0-15 peroxisome proliferator activated receptor gamma Homo sapiens 36-84 18211635-2 2008 n-3 fatty acids are ligands for the peroxisome proliferator-activated receptor-gamma (PPARG), which has recently been implicated in the control of inflammation and possibly autoimmunity. Fatty Acids, Omega-3 0-15 peroxisome proliferator activated receptor gamma Homo sapiens 86-91 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 interleukin 1 beta Homo sapiens 88-97 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 100-127 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 129-138 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 144-157 18296320-4 2008 Omega-3 fatty acids have strong anti-inflammatory effects, suppress interleukin 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids tend to be pro-inflammatory. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 159-163 17157859-0 2008 Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids. Fatty Acids, Omega-3 172-187 phospholipase A2 group VII Homo sapiens 0-39 17157859-4 2008 Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). Fatty Acids, Omega-3 31-45 phospholipase A2 group VII Homo sapiens 217-226 18296320-5 2008 Because inflammation is at the base of many chronic diseases, including coronary heart disease, dietary intake of omega-3 fatty acids plays an important role in the manifestation of disease, particularly in persons with genetic variation, as for example in individuals with genetic variants at the 5-lipoxygenase (5-LO). Fatty Acids, Omega-3 114-133 arachidonate 5-lipoxygenase Homo sapiens 298-312 17311056-1 2008 OBJECTIVE: To test whether breastfeeding"s protection against anorectic responses to infection is mediated by n-3 fatty acids" attenuation of interleukin (IL)-1beta and tumor necrosis factor (TNF)alpha. Fatty Acids, Omega-3 110-125 interleukin 1 beta Homo sapiens 142-164 17311056-1 2008 OBJECTIVE: To test whether breastfeeding"s protection against anorectic responses to infection is mediated by n-3 fatty acids" attenuation of interleukin (IL)-1beta and tumor necrosis factor (TNF)alpha. Fatty Acids, Omega-3 110-125 tumor necrosis factor Homo sapiens 192-201 18160637-6 2007 Because lipoprotein receptors are typically lipid-regulated, we postulated that LR11 is regulated by docosahexaenoic acid (DHA), an essential omega-3 fatty acid related to reduced AD risk and reduced Abeta accumulation. Fatty Acids, Omega-3 142-160 sortilin related receptor 1 Rattus norvegicus 80-84 19776625-3 2008 The newly generated fat-1 transgenic mouse was genetically engineered to carry a gene, namely fat-1, from the round worm Caenorhabditis elegans and is capable of converting n-6 to n-3 fatty acids (which is naturally impossible in mammals), leading to an increase in n-3 fatty acid content with a balanced n-6/n-3 fatty acid ratio in all tissues, independent of diet. Fatty Acids, Omega-3 180-195 FAT atypical cadherin 1 Mus musculus 20-25 19776625-3 2008 The newly generated fat-1 transgenic mouse was genetically engineered to carry a gene, namely fat-1, from the round worm Caenorhabditis elegans and is capable of converting n-6 to n-3 fatty acids (which is naturally impossible in mammals), leading to an increase in n-3 fatty acid content with a balanced n-6/n-3 fatty acid ratio in all tissues, independent of diet. Fatty Acids, Omega-3 180-195 FAT atypical cadherin 1 Mus musculus 94-99 19776625-3 2008 The newly generated fat-1 transgenic mouse was genetically engineered to carry a gene, namely fat-1, from the round worm Caenorhabditis elegans and is capable of converting n-6 to n-3 fatty acids (which is naturally impossible in mammals), leading to an increase in n-3 fatty acid content with a balanced n-6/n-3 fatty acid ratio in all tissues, independent of diet. Fatty Acids, Omega-3 180-194 FAT atypical cadherin 1 Mus musculus 20-25 19776625-3 2008 The newly generated fat-1 transgenic mouse was genetically engineered to carry a gene, namely fat-1, from the round worm Caenorhabditis elegans and is capable of converting n-6 to n-3 fatty acids (which is naturally impossible in mammals), leading to an increase in n-3 fatty acid content with a balanced n-6/n-3 fatty acid ratio in all tissues, independent of diet. Fatty Acids, Omega-3 180-194 FAT atypical cadherin 1 Mus musculus 94-99 19776627-0 2008 Effect of the PPAR-Alpha L162V polymorphism on the cardiovascular disease risk factor in response to n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 101-132 peroxisome proliferator activated receptor alpha Homo sapiens 14-24 19776627-3 2008 Since fatty acids, including n-3 PUFAs, are natural ligands of PPARalpha, a gene-diet interaction effect could be observed. Fatty Acids, Omega-3 29-38 peroxisome proliferator activated receptor alpha Homo sapiens 63-72 18223605-8 2008 For instance, n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic and docosahexaenoic acids are preferentially oxidizied to other PUFA but results remain inconsistent. Fatty Acids, Omega-3 14-45 pumilio RNA binding family member 3 Homo sapiens 47-51 18769551-1 2008 Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)gamma and, due to the effects of PPARgamma on cell proliferation, survival, and differentiation, are potential anticancer agents. Fatty Acids, Omega-3 0-7 peroxisome proliferator activated receptor gamma Homo sapiens 143-153 18769551-1 2008 Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)gamma and, due to the effects of PPARgamma on cell proliferation, survival, and differentiation, are potential anticancer agents. Fatty Acids, Omega-3 0-7 peroxisome proliferator activated receptor gamma Homo sapiens 181-190 18769551-1 2008 Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)gamma and, due to the effects of PPARgamma on cell proliferation, survival, and differentiation, are potential anticancer agents. Fatty Acids, Omega-3 12-44 peroxisome proliferator activated receptor gamma Homo sapiens 143-153 18769551-1 2008 Omega-3 (or n-3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural ligands for peroxisome proliferator receptor activator (PPAR)gamma and, due to the effects of PPARgamma on cell proliferation, survival, and differentiation, are potential anticancer agents. Fatty Acids, Omega-3 12-44 peroxisome proliferator activated receptor gamma Homo sapiens 181-190 18160637-0 2007 Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer"s disease (AD): relevance to AD prevention. Fatty Acids, Omega-3 0-18 sortilin related receptor 1 Rattus norvegicus 56-60 17686536-0 2007 Olfactory discrimination ability and brain expression of c-fos, Gir and Glut1 mRNA are altered in n-3 fatty acid-depleted rats. Fatty Acids, Omega-3 98-112 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 57-62 17475460-0 2007 COX-2 expression in cystic kidneys is dependent on dietary n-3 fatty acid composition. Fatty Acids, Omega-3 59-73 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-5 17475460-1 2007 Dietary n-3 fatty acids generally attenuate elevated cyclooxygenase-2 (COX-2) levels in disease states. Fatty Acids, Omega-3 8-23 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 53-69 17475460-1 2007 Dietary n-3 fatty acids generally attenuate elevated cyclooxygenase-2 (COX-2) levels in disease states. Fatty Acids, Omega-3 8-23 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 71-76 17475460-3 2007 Therefore, the in vivo regulation of COX-2 expression by dietary n-3 fatty acids was examined. Fatty Acids, Omega-3 65-80 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 37-42 17623719-1 2007 BACKGROUND: We previously reported that haemodialysis patients have suboptimal blood levels of the cardioprotective omega-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. Fatty Acids, Omega-3 116-151 pumilio RNA binding family member 3 Homo sapiens 157-161 17686536-0 2007 Olfactory discrimination ability and brain expression of c-fos, Gir and Glut1 mRNA are altered in n-3 fatty acid-depleted rats. Fatty Acids, Omega-3 98-112 G protein-coupled receptor 83 Rattus norvegicus 64-67 17686536-0 2007 Olfactory discrimination ability and brain expression of c-fos, Gir and Glut1 mRNA are altered in n-3 fatty acid-depleted rats. Fatty Acids, Omega-3 98-112 solute carrier family 2 member 1 Rattus norvegicus 72-77 18042365-3 2007 The fat-1 transgenic mice are capable of producing n-3 fatty acids from the n-6 type, leading to abundant n-3 fatty acids with reduced levels of n-6 fatty acids in their organs and tissues, without the need of a dietary n-3 supply. Fatty Acids, Omega-3 51-66 FAT atypical cadherin 1 Mus musculus 4-9 17713802-1 2007 Omega-3 polyunsaturated fatty acids (n-3 PUFA) are noted for their ability to diminish inflammatory and immune responses in vitro and in a variety of animal-based models of autoimmunity and inflammation. Fatty Acids, Omega-3 0-35 pumilio RNA binding family member 3 Homo sapiens 41-45 18042365-3 2007 The fat-1 transgenic mice are capable of producing n-3 fatty acids from the n-6 type, leading to abundant n-3 fatty acids with reduced levels of n-6 fatty acids in their organs and tissues, without the need of a dietary n-3 supply. Fatty Acids, Omega-3 106-121 FAT atypical cadherin 1 Mus musculus 4-9 18042368-3 2007 GLUT1 expression in the cerebral cortex microvessels of rats fed different amounts of n-3 PUFA (low vs. adequate vs. high) was studied. Fatty Acids, Omega-3 86-94 solute carrier family 2 member 1 Rattus norvegicus 0-5 17970622-5 2007 In addition, we show that dietary supplementation of omega-3 fatty acids that ameliorates protein oxidation was effective to reverse the reduction of Sir2alpha level in injured rats. Fatty Acids, Omega-3 53-72 sirtuin 1 Rattus norvegicus 150-159 17970622-9 2007 Omega-3 fatty acids supplements normalized the levels of uMtCK after lesion. Fatty Acids, Omega-3 0-19 creatine kinase, mitochondrial 1B Homo sapiens 57-62 17970622-10 2007 Furthermore, we found that the correlation between Sir2alpha and AMPK or p-AMPK was disrupted by TBI, but restored by omega-3 fatty acids supplements. Fatty Acids, Omega-3 118-137 sirtuin 1 Homo sapiens 51-60 17970622-10 2007 Furthermore, we found that the correlation between Sir2alpha and AMPK or p-AMPK was disrupted by TBI, but restored by omega-3 fatty acids supplements. Fatty Acids, Omega-3 118-137 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 65-69 17970622-10 2007 Furthermore, we found that the correlation between Sir2alpha and AMPK or p-AMPK was disrupted by TBI, but restored by omega-3 fatty acids supplements. Fatty Acids, Omega-3 118-137 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 75-79 17634405-4 2007 An increased tissue content of omega-3 polyunsaturated fatty acids (n-3 PUFA) can dampen colon inflammation in animals as well as in humans. Fatty Acids, Omega-3 31-66 pumilio RNA binding family member 3 Homo sapiens 72-76 17869078-8 2007 Furthermore, there is evidence that 15-LOX is involved in the metabolism of the long-chain omega-3 fatty acid docosahexaenoic acid (DHA) leading to a family of anti-inflammatory resolvins and protectins. Fatty Acids, Omega-3 91-109 arachidonate 15-lipoxygenase type B Homo sapiens 36-42 17697863-11 2007 Although the change in adiponectin in response to the omega-3 fatty acids was not accompanied by any change in glucose, insulin, or quantitative insulin sensitivity check index, long-term implications of such a decrease should be considered in future studies. Fatty Acids, Omega-3 54-73 adiponectin, C1Q and collagen domain containing Homo sapiens 23-34 17693979-8 2007 It is suggested that CFS patients should be treated with antioxidants, which inhibit the production of NFkappabeta, such as curcumin, N-Acetyl-Cysteine, quercitin, silimarin, lipoic acid and omega-3 fatty acids. Fatty Acids, Omega-3 191-210 nuclear factor kappa B subunit 1 Homo sapiens 103-114 17600534-5 2007 RESULTS: Rats on the omega-3 FA diet exhibited decreased proinflammatory cytokine gene expression (IL-1beta, TNF-alpha) and enhanced IFN-gamma, CAT and SOD messenger RNA expression compared to rats fed a corn oil diet, supporting a diet-induced modulation of host inflammatory reactions. Fatty Acids, Omega-3 21-31 interleukin 1 beta Rattus norvegicus 99-107 17600534-5 2007 RESULTS: Rats on the omega-3 FA diet exhibited decreased proinflammatory cytokine gene expression (IL-1beta, TNF-alpha) and enhanced IFN-gamma, CAT and SOD messenger RNA expression compared to rats fed a corn oil diet, supporting a diet-induced modulation of host inflammatory reactions. Fatty Acids, Omega-3 21-31 tumor necrosis factor Rattus norvegicus 109-118 17600534-5 2007 RESULTS: Rats on the omega-3 FA diet exhibited decreased proinflammatory cytokine gene expression (IL-1beta, TNF-alpha) and enhanced IFN-gamma, CAT and SOD messenger RNA expression compared to rats fed a corn oil diet, supporting a diet-induced modulation of host inflammatory reactions. Fatty Acids, Omega-3 21-31 interferon gamma Rattus norvegicus 133-142 17607361-5 2007 Introducing an omega-3 desaturase, which converts omega-6 to omega-3 fatty acids, into the Pten-knockout mice reduced tumor growth similarly to the omega-3 diet. Fatty Acids, Omega-3 61-80 phosphatase and tensin homolog Mus musculus 91-95 17607361-5 2007 Introducing an omega-3 desaturase, which converts omega-6 to omega-3 fatty acids, into the Pten-knockout mice reduced tumor growth similarly to the omega-3 diet. Fatty Acids, Omega-3 15-22 phosphatase and tensin homolog Mus musculus 91-95 17510185-0 2007 Protein kinase A is activated by the n-3 polyunsaturated fatty acid eicosapentaenoic acid in rat ventricular muscle. Fatty Acids, Omega-3 37-67 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-16 17568059-8 2007 K-ras mutated cases reported a lower intake of vitamin E (ORa = 0.2, p for trend = 0.036), polyunsaturated fats and omega 3 fatty acids (ORa = 0.2; p for trend <0.03). Fatty Acids, Omega-3 91-111 KRAS proto-oncogene, GTPase Homo sapiens 0-5 17568059-8 2007 K-ras mutated cases reported a lower intake of vitamin E (ORa = 0.2, p for trend = 0.036), polyunsaturated fats and omega 3 fatty acids (ORa = 0.2; p for trend <0.03). Fatty Acids, Omega-3 116-135 KRAS proto-oncogene, GTPase Homo sapiens 0-5 17510185-1 2007 During cardiac ischaemia antiarrhythmic n-3 polyunsaturated fatty acids (PUFAs) are released following activation of phospholipase A2, if they are in the diet prior to ischaemia. Fatty Acids, Omega-3 40-71 phospholipase A2 group IB Rattus norvegicus 117-133 17953212-1 2007 OBJECTIVE: To study the effect of n-3 polyunsaturated fatty acids (EPA, DHA) on the production of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte. Fatty Acids, Omega-3 34-65 nitric oxide synthase 2 Homo sapiens 116-120 17598015-0 2007 Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. Fatty Acids, Omega-3 111-125 coagulation factor III, tissue factor Homo sapiens 68-81 17586424-0 2007 The effect of n-3 fatty acids on C-reactive protein levels in patients with chronic renal failure. Fatty Acids, Omega-3 14-29 C-reactive protein Homo sapiens 33-51 17953212-1 2007 OBJECTIVE: To study the effect of n-3 polyunsaturated fatty acids (EPA, DHA) on the production of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte. Fatty Acids, Omega-3 34-65 nuclear factor kappa B subunit 1 Homo sapiens 154-162 17613244-2 2007 The objective of this study was to determine the effect of an isocaloric diet supplemented with a plant-based dietary omega-3 fatty acid [alpha-linolenic acid (ALA)] on interleukin-6, C-reactive protein, serum amyloid A, and tumor necrosis factor-alpha. Fatty Acids, Omega-3 118-136 interleukin 6 Homo sapiens 169-182 17478424-0 2007 Epithelial Na+ channel stimulation by n-3 fatty acids requires proximity to a membrane-bound A-kinase-anchoring protein complexed with protein kinase A and phosphodiesterase. Fatty Acids, Omega-3 38-53 A-kinase anchoring protein 13 Homo sapiens 93-119 17262807-3 2007 However, there are also anti-inflammatory lipid mediators: lipoxins and resolvins, derived from essential omega-6 and omega-3 polyunsaturated fatty acids (n-3 and n-6 PUFA), have been shown to control and resolve inflammation in a variety of experimental models of inflammatory disorders. Fatty Acids, Omega-3 118-153 pumilio RNA binding family member 3 Homo sapiens 167-171 17574755-1 2007 BACKGROUND: In animals, dendritic arborization and levels of brain derived neurotrophic factor are positively associated with intake of the omega-3 fatty acids. Fatty Acids, Omega-3 140-159 brain derived neurotrophic factor Homo sapiens 61-94 17555288-5 2007 Oleic acid or n-3 fatty acids downregulate the expression of leptin, fatty acid synthase and lipoprotein lipase in retroperitoneal adipose tissue. Fatty Acids, Omega-3 14-29 leptin Sus scrofa 61-67 17555288-5 2007 Oleic acid or n-3 fatty acids downregulate the expression of leptin, fatty acid synthase and lipoprotein lipase in retroperitoneal adipose tissue. Fatty Acids, Omega-3 14-29 fatty acid synthase Sus scrofa 69-88 17555288-5 2007 Oleic acid or n-3 fatty acids downregulate the expression of leptin, fatty acid synthase and lipoprotein lipase in retroperitoneal adipose tissue. Fatty Acids, Omega-3 14-29 lipoprotein lipase Sus scrofa 93-111 17613244-2 2007 The objective of this study was to determine the effect of an isocaloric diet supplemented with a plant-based dietary omega-3 fatty acid [alpha-linolenic acid (ALA)] on interleukin-6, C-reactive protein, serum amyloid A, and tumor necrosis factor-alpha. Fatty Acids, Omega-3 118-136 tumor necrosis factor Homo sapiens 204-252 17545695-7 2007 A multiple regression analysis showed that, especially in the middle tertile of long-chain n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) intake, CRP was inversely related to the intake of oleic acid and linoleic acid in both sexes and to the intake of alpha-linolenic acid in women. Fatty Acids, Omega-3 91-100 C-reactive protein Homo sapiens 158-161 17052999-1 2007 N-3 polyunsaturated fatty acids (PUFA) and genistein have been associated with lowered cancer risk by reducing inflammatory prostanoids, cyclooxygenase-2 (COX-2) activity, and altering cell signaling. Fatty Acids, Omega-3 0-31 prostaglandin-endoperoxide synthase 2 Homo sapiens 137-153 17291531-1 2007 BACKGROUND: n-3 fatty acids (n-3FA) have anti-inflammatory and anti-proliferative effects including modulation of pro-inflammatory cascade mediators and cytokine elaboration (i.e., TNF-alpha, IL-10 and PGE(2)) in many cell lines. Fatty Acids, Omega-3 12-27 tumor necrosis factor Homo sapiens 181-190 17291531-1 2007 BACKGROUND: n-3 fatty acids (n-3FA) have anti-inflammatory and anti-proliferative effects including modulation of pro-inflammatory cascade mediators and cytokine elaboration (i.e., TNF-alpha, IL-10 and PGE(2)) in many cell lines. Fatty Acids, Omega-3 12-27 interleukin 10 Homo sapiens 192-197 17291531-1 2007 BACKGROUND: n-3 fatty acids (n-3FA) have anti-inflammatory and anti-proliferative effects including modulation of pro-inflammatory cascade mediators and cytokine elaboration (i.e., TNF-alpha, IL-10 and PGE(2)) in many cell lines. Fatty Acids, Omega-3 29-34 tumor necrosis factor Homo sapiens 181-190 17291531-1 2007 BACKGROUND: n-3 fatty acids (n-3FA) have anti-inflammatory and anti-proliferative effects including modulation of pro-inflammatory cascade mediators and cytokine elaboration (i.e., TNF-alpha, IL-10 and PGE(2)) in many cell lines. Fatty Acids, Omega-3 29-34 interleukin 10 Homo sapiens 192-197 17291531-10 2007 Annexin-V staining of n-3FA-treated cells demonstrated time-dependent increased apoptosis and PARP cleavage was present only in the n-3FA treatment group. Fatty Acids, Omega-3 22-27 annexin A5 Homo sapiens 0-9 17291531-10 2007 Annexin-V staining of n-3FA-treated cells demonstrated time-dependent increased apoptosis and PARP cleavage was present only in the n-3FA treatment group. Fatty Acids, Omega-3 22-27 poly(ADP-ribose) polymerase 1 Homo sapiens 94-98 17291531-10 2007 Annexin-V staining of n-3FA-treated cells demonstrated time-dependent increased apoptosis and PARP cleavage was present only in the n-3FA treatment group. Fatty Acids, Omega-3 132-137 annexin A5 Homo sapiens 0-9 17291531-10 2007 Annexin-V staining of n-3FA-treated cells demonstrated time-dependent increased apoptosis and PARP cleavage was present only in the n-3FA treatment group. Fatty Acids, Omega-3 132-137 poly(ADP-ribose) polymerase 1 Homo sapiens 94-98 17303577-8 2007 In contrast, polyunsaturated fatty acids, especially n-3 polyunsaturated fatty acids, inhibited the activation of NF-kappaB and IL-8 expression induced by lauric acid or known Nods ligands in HCT116. Fatty Acids, Omega-3 53-84 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 17052999-1 2007 N-3 polyunsaturated fatty acids (PUFA) and genistein have been associated with lowered cancer risk by reducing inflammatory prostanoids, cyclooxygenase-2 (COX-2) activity, and altering cell signaling. Fatty Acids, Omega-3 0-31 prostaglandin-endoperoxide synthase 2 Homo sapiens 155-160 17251275-0 2007 n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Fatty Acids, Omega-3 0-15 peroxisome proliferator activated receptor alpha Mus musculus 58-106 17251275-6 2007 These data support the hypothesis that n-3 fatty acids protect from high-fat diet-induced hepatic insulin resistance in a PPAR-alpha-and diacylglycerol-dependent manner. Fatty Acids, Omega-3 39-54 peroxisome proliferator activated receptor alpha Mus musculus 122-132 17342305-0 2007 Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids. Fatty Acids, Omega-3 62-81 BRCA1, DNA repair associated Rattus norvegicus 10-15 17393517-2 2007 Supplementation with essential omega-3 polyunsaturated fatty acids (n-3 PUFA) has been demonstrated to lower TNF-alpha and IL-1 production in mononuclear cells. Fatty Acids, Omega-3 68-76 tumor necrosis factor Mus musculus 109-118 17393517-2 2007 Supplementation with essential omega-3 polyunsaturated fatty acids (n-3 PUFA) has been demonstrated to lower TNF-alpha and IL-1 production in mononuclear cells. Fatty Acids, Omega-3 68-76 interleukin 1 complex Mus musculus 123-127 17119918-1 2007 AIM/HYPOTHESIS: To determine whether marine-derived n-3 polyunsaturated fatty acids (n-3 PUFA) (also known as omega-3 fatty acids) have beneficial effects on haematological and thrombogenic risk markers in addition to dyslipidaemia, in patients with type 2 diabetes. Fatty Acids, Omega-3 52-83 pumilio RNA binding family member 3 Homo sapiens 89-93 17608265-7 2007 Circulating adiponectin values, were positively associated with the proportion of n-3 polyunsaturated fatty acids in plasma (r=0.62, P=0.002). Fatty Acids, Omega-3 82-113 adiponectin, C1Q and collagen domain containing Homo sapiens 12-23 17328054-0 2007 Novel action of n-3 polyunsaturated fatty acids: inhibition of arachidonic acid-induced increase in tumor necrosis factor receptor expression on neutrophils and a role for proteases. Fatty Acids, Omega-3 16-47 tumor necrosis factor Homo sapiens 100-121 16794572-0 2007 Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion. Fatty Acids, Omega-3 0-18 interleukin 1 beta Homo sapiens 54-62 16794572-0 2007 Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion. Fatty Acids, Omega-3 0-18 phospholipase A2 group IB Homo sapiens 160-164 17311938-6 2007 As sustained activation of the EGFR and p38 MAPK has been associated with apoptosis in human breast cancer cells, our results indicate that (n-3) FA modify the lipid composition of membrane rafts and alter EGFR signaling in a way that decreases the growth of breast tumors. Fatty Acids, Omega-3 140-148 epidermal growth factor receptor Homo sapiens 31-35 17311938-6 2007 As sustained activation of the EGFR and p38 MAPK has been associated with apoptosis in human breast cancer cells, our results indicate that (n-3) FA modify the lipid composition of membrane rafts and alter EGFR signaling in a way that decreases the growth of breast tumors. Fatty Acids, Omega-3 140-148 epidermal growth factor receptor Homo sapiens 206-210 17546842-13 2007 No change during the control period regarding baseline occurred when placebo was randomized to be given first; however, when it followed omega-3 supplementation, CRP and SAA recovered, whereas WBC and fibronection remained depressed during those 2 weeks (7500 +/- 2100/mm3 and 393.2 +/- 75.8 mg/dL, P<0.05). Fatty Acids, Omega-3 137-144 C-reactive protein Homo sapiens 162-165 17301265-1 2007 BACKGROUND: N-3 fatty acids may decrease risk of colorectal cancer by inhibiting the cyclooxygenase-2 enzyme and production of proinflammatory eicosanoids derived from arachidonic acid (20:4n-6). Fatty Acids, Omega-3 12-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 85-101 17119918-1 2007 AIM/HYPOTHESIS: To determine whether marine-derived n-3 polyunsaturated fatty acids (n-3 PUFA) (also known as omega-3 fatty acids) have beneficial effects on haematological and thrombogenic risk markers in addition to dyslipidaemia, in patients with type 2 diabetes. Fatty Acids, Omega-3 110-129 pumilio RNA binding family member 3 Homo sapiens 89-93 17127771-0 2007 Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. Fatty Acids, Omega-3 6-20 NFE2 like bZIP transcription factor 2 Homo sapiens 49-53 17127771-0 2007 Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. Fatty Acids, Omega-3 6-20 kelch like ECH associated protein 1 Homo sapiens 95-100 17127771-0 2007 Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. Fatty Acids, Omega-3 6-20 cullin 3 Homo sapiens 105-112 17127771-4 2007 Oxidized n-3 fatty acids reacted directly with the negative regulator of Nrf2, Keap1, initiating Keap1 dissociation with Cullin3, thereby inducing Nrf2-directed gene expression. Fatty Acids, Omega-3 9-24 NFE2 like bZIP transcription factor 2 Homo sapiens 73-77 17127771-4 2007 Oxidized n-3 fatty acids reacted directly with the negative regulator of Nrf2, Keap1, initiating Keap1 dissociation with Cullin3, thereby inducing Nrf2-directed gene expression. Fatty Acids, Omega-3 9-24 kelch like ECH associated protein 1 Homo sapiens 79-84 17127771-4 2007 Oxidized n-3 fatty acids reacted directly with the negative regulator of Nrf2, Keap1, initiating Keap1 dissociation with Cullin3, thereby inducing Nrf2-directed gene expression. Fatty Acids, Omega-3 9-24 kelch like ECH associated protein 1 Homo sapiens 97-102 17127771-4 2007 Oxidized n-3 fatty acids reacted directly with the negative regulator of Nrf2, Keap1, initiating Keap1 dissociation with Cullin3, thereby inducing Nrf2-directed gene expression. Fatty Acids, Omega-3 9-24 cullin 3 Homo sapiens 121-128 17127771-4 2007 Oxidized n-3 fatty acids reacted directly with the negative regulator of Nrf2, Keap1, initiating Keap1 dissociation with Cullin3, thereby inducing Nrf2-directed gene expression. Fatty Acids, Omega-3 9-24 NFE2 like bZIP transcription factor 2 Homo sapiens 147-151 17049785-3 2007 This has prompted ongoing clinical trials in AD patients to test the efficacy of improving insulin - like signaling with dietary omega-3 fatty acids or insulin - sensitizing drugs as well as exercise regimens. Fatty Acids, Omega-3 129-148 insulin Homo sapiens 91-98 17356263-10 2007 Significant (p < 0.05) improvement in n-6/n-3 fatty acid ratio was observed for all chia diets when compared to the control. Fatty Acids, Omega-3 45-59 chitinase, acidic Rattus norvegicus 87-91 17691948-0 2007 Anti-arrhythmic properties of N-3 poly-unsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 30-62 pumilio RNA binding family member 3 Homo sapiens 68-72 17691948-1 2007 Omega-3 fatty acids (Poly-Unsaturated Fatty Acids or PUFA n-3) have been initially found to reduce plasma levels of triglycerides and to increase levels of high-density lipoprotein in patients with marked hypertriglyceridemia. Fatty Acids, Omega-3 0-19 pumilio RNA binding family member 3 Homo sapiens 53-57 17429201-0 2007 Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn"s disease treated with prednisolone. Fatty Acids, Omega-3 44-63 leptin Homo sapiens 135-141 17038422-0 2007 TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 28-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17038422-2 2007 Here we show that n-3 fatty acids interact directly with TRPV1, an ion channel expressed in nociceptive neurones and brain. Fatty Acids, Omega-3 18-33 transient receptor potential cation channel subfamily V member 1 Homo sapiens 57-62 17038422-9 2007 Thus, n-3 fatty acids differentially regulate TRPV1 and this form of signalling may contribute to their biological effects. Fatty Acids, Omega-3 6-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 17192169-4 2007 Some studies have demonstrated that consumption of fish oil concentrate, n-3 polyunsaturated fatty acid (n-3 PUFA), results in cardiovascular benefits that include reductions in mortality, sudden death, nonfatal myocardial infarction, and thrombotic stoke, as well as improvement in graft patency. Fatty Acids, Omega-3 73-103 pumilio RNA binding family member 3 Homo sapiens 109-113 16983391-0 2007 n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Fatty Acids, Omega-3 0-30 brain-derived neurotrophic factor Rattus norvegicus 76-80 17982923-1 2007 BACKGROUND: The anti-inflammatory effects of n-3 polyunsaturated fatty acids (n-3 PUFA) have been demonstrated both in vitro and in vivo. Fatty Acids, Omega-3 45-76 pumilio RNA binding family member 3 Homo sapiens 82-86 16517146-0 2006 n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. Fatty Acids, Omega-3 8-39 cytochrome P450 2B1 Rattus norvegicus 54-74 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 interleukin 1 beta Homo sapiens 61-78 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 interleukin 1 beta Homo sapiens 80-88 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 91-118 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 120-128 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 134-147 17045449-5 2006 Omega-3 fatty acids have anti-inflammatory effects, suppress interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha) and interleukin-6 (IL-6), whereas omega-6 fatty acids do not. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 149-153 17045449-6 2006 Because inflammation is at the base of many chronic diseases, dietary intake of omega-3 fatty acids plays an important role in the manifestation of disease, particularly in persons with genetic variation, as for example in individuals with genetic variants at the 5-lipoxygenase (5-LO). Fatty Acids, Omega-3 80-99 arachidonate 5-lipoxygenase Homo sapiens 264-278 17018645-0 2006 The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition. Fatty Acids, Omega-3 4-22 prostaglandin-endoperoxide synthase 2 Homo sapiens 63-79 17497447-0 2007 Effects of N-3 PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. Fatty Acids, Omega-3 11-20 insulin Homo sapiens 40-47 17497447-1 2007 AIMS/HYPOTHESIS: It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. Fatty Acids, Omega-3 72-81 insulin Homo sapiens 97-104 17497447-2 2007 This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Fatty Acids, Omega-3 45-54 insulin Homo sapiens 78-85 17497447-2 2007 This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Fatty Acids, Omega-3 45-54 insulin Homo sapiens 231-238 16792994-0 2006 Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1beta. Fatty Acids, Omega-3 0-19 interleukin 1 beta Homo sapiens 104-112 16792994-1 2006 OBJECTIVE: The objective of this study was to determine the effect of omega-3 fatty acids (eicosapentaenoic acid [EPA]; docosahexaenoic acid [DHA]) on prostaglandin production and prostanoid enzyme expression in cultured decidual cells exposed to interleukin-1beta (IL-1beta), a cytokine that plays a major role in inflammation. Fatty Acids, Omega-3 70-89 interleukin 1 beta Homo sapiens 247-264 16792994-1 2006 OBJECTIVE: The objective of this study was to determine the effect of omega-3 fatty acids (eicosapentaenoic acid [EPA]; docosahexaenoic acid [DHA]) on prostaglandin production and prostanoid enzyme expression in cultured decidual cells exposed to interleukin-1beta (IL-1beta), a cytokine that plays a major role in inflammation. Fatty Acids, Omega-3 70-89 interleukin 1 beta Homo sapiens 266-274 17699343-0 2006 Efficacy of omega-3 fatty acids in children and adults with IgA nephropathy is dosage- and size-dependent. Fatty Acids, Omega-3 12-31 immunoglobulin heavy variable 4-38-2-like Homo sapiens 60-63 16960073-8 2006 Milk total n-3 fatty acids were increased (0.82, 0.96, 0.92, and 1.01 g/100 g of fatty acids) by all fat-supplemented diets. Fatty Acids, Omega-3 11-26 Weaning weight-maternal milk Bos taurus 0-4 16524712-1 2006 Clinical trials have revealed that progression of immunoglobulin A nephropathy (IgAN), the most common form of human glomerulonephritis, is inhibited by dietary (n-3) polyunsaturated fatty acid (PUFA) supplementation. Fatty Acids, Omega-3 162-193 IGAN1 Homo sapiens 80-84 16783472-0 2006 Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 92-123 WD and tetratricopeptide repeats 1 Mus musculus 0-7 16936261-6 2006 Supplementation of n-3 polyunsaturated fatty acid, a PPARalpha ligand, to HFD-treated animals restored hepatic adiponectin and PPARalpha expression, reduced TNF-alpha hepatic levels, and ameliorated fatty liver and the degree of liver injury. Fatty Acids, Omega-3 19-49 peroxisome proliferator activated receptor alpha Rattus norvegicus 53-62 16936261-6 2006 Supplementation of n-3 polyunsaturated fatty acid, a PPARalpha ligand, to HFD-treated animals restored hepatic adiponectin and PPARalpha expression, reduced TNF-alpha hepatic levels, and ameliorated fatty liver and the degree of liver injury. Fatty Acids, Omega-3 19-49 adiponectin, C1Q and collagen domain containing Rattus norvegicus 111-122 16936261-6 2006 Supplementation of n-3 polyunsaturated fatty acid, a PPARalpha ligand, to HFD-treated animals restored hepatic adiponectin and PPARalpha expression, reduced TNF-alpha hepatic levels, and ameliorated fatty liver and the degree of liver injury. Fatty Acids, Omega-3 19-49 peroxisome proliferator activated receptor alpha Rattus norvegicus 127-136 16936261-6 2006 Supplementation of n-3 polyunsaturated fatty acid, a PPARalpha ligand, to HFD-treated animals restored hepatic adiponectin and PPARalpha expression, reduced TNF-alpha hepatic levels, and ameliorated fatty liver and the degree of liver injury. Fatty Acids, Omega-3 19-49 tumor necrosis factor Rattus norvegicus 157-166 16936261-7 2006 Thus, our model mimics the most common features of NASH in humans and provides an ideal tool to study the role of individual pathogenetic events (as for PPARalpha down-regulation) and to define any future experimental therapy, such as n-3 polyunsaturated fatty acid, which ameliorated the degree of liver injury. Fatty Acids, Omega-3 235-265 peroxisome proliferator activated receptor alpha Homo sapiens 153-162 16919514-5 2006 Omega-3 fatty acids elicit hypotriglyceridemic effects by coordinately suppressing hepatic lipogenesis through reducing levels of SREBP-1c, upregulating fatty oxidation in the liver and skeletal muscle through PPAR activation, and enhancing flux of glucose to glycogen through downregulation of HNF-4alpha. Fatty Acids, Omega-3 0-19 sterol regulatory element binding transcription factor 1 Homo sapiens 130-138 16889775-1 2006 In this study the n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid and docosahexaenoic acid appear to be effective inducers of electrophile-responsive element (EpRE) regulated genes, whereas the n-6 PUFA arachidonic acid is not. Fatty Acids, Omega-3 18-49 pumilio RNA binding family member 3 Homo sapiens 51-55 16919514-5 2006 Omega-3 fatty acids elicit hypotriglyceridemic effects by coordinately suppressing hepatic lipogenesis through reducing levels of SREBP-1c, upregulating fatty oxidation in the liver and skeletal muscle through PPAR activation, and enhancing flux of glucose to glycogen through downregulation of HNF-4alpha. Fatty Acids, Omega-3 0-19 peroxisome proliferator activated receptor alpha Homo sapiens 210-214 16919514-5 2006 Omega-3 fatty acids elicit hypotriglyceridemic effects by coordinately suppressing hepatic lipogenesis through reducing levels of SREBP-1c, upregulating fatty oxidation in the liver and skeletal muscle through PPAR activation, and enhancing flux of glucose to glycogen through downregulation of HNF-4alpha. Fatty Acids, Omega-3 0-19 hepatocyte nuclear factor 4 alpha Homo sapiens 295-305 16919514-8 2006 Additionally, peroxidation of omega-3 fatty acids may reduce VLDL secretion through stimulating apolipoprotein B degradation. Fatty Acids, Omega-3 30-49 apolipoprotein B Homo sapiens 96-112 16701922-12 2006 CONCLUSIONS: Dietary supplementation with 500 cm(3) of enriched milk with omega-3 fatty acid, oleic acid and folic acid, reduces serum tryglicerides, total and LDL cholesterol, Apo B, glucose and homocysteine in patients with MS. Fatty Acids, Omega-3 74-92 apolipoprotein B Homo sapiens 177-182 16888035-2 2006 The recently engineered fat-1 mice, which can convert n-6 to n-3 fatty acids and have a balanced ratio of n-6 to n-3 fatty acids in their tissues and organs independent of diet, allow carefully controlled studies to be performed in the absence of potential confounding factors of diet and therefore are a useful model for elucidating the role of n-6/n-3 fatty acid ratio in tumorigenesis. Fatty Acids, Omega-3 61-76 FAT atypical cadherin 1 Mus musculus 24-29 16888035-2 2006 The recently engineered fat-1 mice, which can convert n-6 to n-3 fatty acids and have a balanced ratio of n-6 to n-3 fatty acids in their tissues and organs independent of diet, allow carefully controlled studies to be performed in the absence of potential confounding factors of diet and therefore are a useful model for elucidating the role of n-6/n-3 fatty acid ratio in tumorigenesis. Fatty Acids, Omega-3 113-128 FAT atypical cadherin 1 Mus musculus 24-29 16888035-2 2006 The recently engineered fat-1 mice, which can convert n-6 to n-3 fatty acids and have a balanced ratio of n-6 to n-3 fatty acids in their tissues and organs independent of diet, allow carefully controlled studies to be performed in the absence of potential confounding factors of diet and therefore are a useful model for elucidating the role of n-6/n-3 fatty acid ratio in tumorigenesis. Fatty Acids, Omega-3 61-75 FAT atypical cadherin 1 Mus musculus 24-29 16888035-5 2006 The level of n-3 fatty acids and their metabolite prostaglandin E(3) (PGE(3)) were much higher (but the n-6/n-3 ratio is much lower) in the tumor and surrounding tissues of fat-1 mice than that of WT animals. Fatty Acids, Omega-3 13-28 FAT atypical cadherin 1 Mus musculus 173-178 16888035-7 2006 In vitro experiments showed that addition of the n-3 fatty acid eicosapentaenoic acid or PGE(3) inhibited the growth of B16 cell line and increased the expression of PTEN, which could be partially attenuated by inhibition of PGE(3) production, suggesting that PGE(3) may act as an antitumor mediator. Fatty Acids, Omega-3 49-63 phosphatase and tensin homolog Mus musculus 166-170 16888035-8 2006 These data demonstrate an anticancer (antimelanoma) effect of n-3 fatty acids through, at least in part, activation of PTEN pathway mediated by PGE(3). Fatty Acids, Omega-3 62-77 phosphatase and tensin homolog Mus musculus 119-123 16697496-1 2006 BACKGROUND & AIMS: n-3 fatty acids are expected to downregulate the inflammatory responses, and hence may decrease insulin resistance. Fatty Acids, Omega-3 23-38 insulin Homo sapiens 119-126 16584347-15 2006 However, the failure to observe any significant inhibition of bone loss in celecoxib- and/or omega-3 fatty acid-treated rats compared to the LPS group suggests that their therapeutic effect may be reduced by other factors, such as increases in serum IL-1beta promoting osteoclast activity. Fatty Acids, Omega-3 93-111 interleukin 1 beta Rattus norvegicus 250-258 16825699-1 2006 BACKGROUND: Several studies have reported that the intake of n-3 polyunsaturated fatty acids (PUFAs) or fish is inversely associated with serum C-reactive protein (CRP) concentrations, but few studies have evaluated the relations between serum CRP concentrations and consumption of n-3 PUFAs derived from marine products in populations with a diet rich in marine products. Fatty Acids, Omega-3 61-92 C-reactive protein Homo sapiens 144-162 16825699-1 2006 BACKGROUND: Several studies have reported that the intake of n-3 polyunsaturated fatty acids (PUFAs) or fish is inversely associated with serum C-reactive protein (CRP) concentrations, but few studies have evaluated the relations between serum CRP concentrations and consumption of n-3 PUFAs derived from marine products in populations with a diet rich in marine products. Fatty Acids, Omega-3 61-92 C-reactive protein Homo sapiens 164-167 16825699-8 2006 CONCLUSIONS: Greater intake of n-3 PUFAs derived from marine products, as measured with a self-administered questionnaire, was independently related to a lower prevalence of high CRP concentrations in this older Japanese population with a diet rich in marine products. Fatty Acids, Omega-3 31-40 C-reactive protein Homo sapiens 179-182 16825699-9 2006 Our findings suggest that even very high intakes of n-3 PUFAs may lower serum CRP concentrations. Fatty Acids, Omega-3 52-61 C-reactive protein Homo sapiens 78-81 16869997-0 2006 Effect of n-3 fatty acids on metabolism of apoB100-containing lipoprotein in type 2 diabetic subjects. Fatty Acids, Omega-3 10-25 apolipoprotein B Homo sapiens 43-50 16869997-9 2006 In conclusion, the present study, conducted in the fasting state, showed that supplementation with n-3 fatty acids in type 2 diabetic patients induced beneficial changes in the metabolism of apoB100-containing lipoprotein. Fatty Acids, Omega-3 99-114 apolipoprotein B Homo sapiens 191-198 16671691-1 2006 Recent NMR experiments and molecular dynamics simulations have indicated that rhodopsin is preferentially solvated by omega-3 fatty acids compared to saturated chains. Fatty Acids, Omega-3 118-137 rhodopsin Homo sapiens 78-87 16671873-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 145-163 16671873-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 165-173 16499938-8 2006 These results indicated that n-3 fatty acid containing spray-dried milk formulation would bring about the hypocholesterolemic effect by lowering HMG Co A reductase activity in liver and by increasing the secretion of bile constituents. Fatty Acids, Omega-3 29-43 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 145-163 29539151-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 156-174 16644726-2 2006 n-3 polyunsaturated fatty acids (PUFA) and WY14643 (peroxisome proliferator-activated receptor alpha (PPARalpha) agonist) interfere with glucose-stimulated L-PK gene transcription in vivo and in rat primary hepatocytes. Fatty Acids, Omega-3 0-31 peroxisome proliferator activated receptor alpha Rattus norvegicus 102-111 16644726-2 2006 n-3 polyunsaturated fatty acids (PUFA) and WY14643 (peroxisome proliferator-activated receptor alpha (PPARalpha) agonist) interfere with glucose-stimulated L-PK gene transcription in vivo and in rat primary hepatocytes. Fatty Acids, Omega-3 0-31 pyruvate kinase L/R Rattus norvegicus 156-160 16818127-6 2006 n-3 fatty acids resulted in a 59% reduction in TNF-alpha (from 1.64 to 0.68 pg/ml; p = 0.02) and 39% decrease in IL-1 (from 1.98 to 1.21 pg/ml; p = 0.09) production. Fatty Acids, Omega-3 0-15 tumor necrosis factor Homo sapiens 47-56 16818127-6 2006 n-3 fatty acids resulted in a 59% reduction in TNF-alpha (from 1.64 to 0.68 pg/ml; p = 0.02) and 39% decrease in IL-1 (from 1.98 to 1.21 pg/ml; p = 0.09) production. Fatty Acids, Omega-3 0-15 interleukin 1 alpha Homo sapiens 113-117 16698153-1 2006 BACKGROUND AND AIMS: Conjugated linoleic acid (CLA) and n-3 polyunsaturated fatty acids (PUFA) have been proposed as important pharmaco-nutrients for modulating mucosal immunity and therapeutic responses in patients with inflammatory bowel disease (IBD). Fatty Acids, Omega-3 56-87 Polyunsaturated fatty acid percentage Sus scrofa 89-93 17217160-3 2006 Eicosapentaenoic acid (EPA) is a dietary n-3 polyunsaturated fatty acid that improves insulin sensitivity in several models of obesity and diabetes, which has been suggested to be related to adiponectin induction. Fatty Acids, Omega-3 41-71 adiponectin, C1Q and collagen domain containing Rattus norvegicus 191-202 29539164-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 145-163 29539164-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 165-173 22062055-9 2006 These results suggest that the outdoor rearing allows a higher accumulation of n-3 fatty acids maybe due to an increased activity of the desaturase and elongase enzymes. Fatty Acids, Omega-3 79-94 ELOVL fatty acid elongase 5 Sus scrofa 152-160 16584347-0 2006 Effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. Fatty Acids, Omega-3 52-70 interleukin 1 beta Rattus norvegicus 80-97 16584347-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 156-174 16584347-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 176-184 16584347-10 2006 Omega-3 fatty acid, both alone and in combination with celecoxib, revealed significantly higher IL-1beta levels than LPS and celecoxib groups (P <0.05). Fatty Acids, Omega-3 0-18 interleukin 1 beta Rattus norvegicus 96-104 16584347-14 2006 The significantly increased serum OC level observed after individual and combination administration suggests that celecoxib and omega-3 fatty acid may influence bone remodeling and thereby inhibit the progression of alveolar bone resorption. Fatty Acids, Omega-3 128-146 bone gamma-carboxyglutamate protein Rattus norvegicus 34-36 29539151-10 2006 Omega-3 fatty acid, both alone and in combination with celecoxib, revealed significantly higher IL-1beta levels than LPS and celecoxib groups (P <0.05). Fatty Acids, Omega-3 0-18 interleukin 1 beta Rattus norvegicus 96-104 29539151-14 2006 The significantly increased serum OC level observed after individual and combination administration suggests that celecoxib and omega-3 fatty acid may influence bone remodeling and thereby inhibit the progression of alveolar bone resorption. Fatty Acids, Omega-3 128-146 bone gamma-carboxyglutamate protein Rattus norvegicus 34-36 29539151-15 2006 However, the failure to observe any significant inhibition of bone loss in celecoxib- and/or omega-3 fatty acid-treated rats compared to the LPS group suggests that their therapeutic effect may be reduced by other factors, such as increases in serum IL-1beta promoting osteoclast activity. Fatty Acids, Omega-3 93-111 interleukin 1 beta Rattus norvegicus 250-258 29539151-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 176-184 16531984-4 2006 Omega-3 may interfere with the arachidonic acid cascade by inhibiting 5-Lox. Fatty Acids, Omega-3 0-7 arachidonate 5-lipoxygenase Homo sapiens 70-75 16531984-7 2006 Administration of omega-3 reduced significantly lipid peroxidation (P < 0.0001), LTB(4) synthesis (P < 0.0001) and 5-Lox activity (P < 0.0001), with no effect on 5-Lox protein expression. Fatty Acids, Omega-3 18-25 lysyl oxidase Homo sapiens 123-126 16531984-7 2006 Administration of omega-3 reduced significantly lipid peroxidation (P < 0.0001), LTB(4) synthesis (P < 0.0001) and 5-Lox activity (P < 0.0001), with no effect on 5-Lox protein expression. Fatty Acids, Omega-3 18-25 arachidonate 5-lipoxygenase Homo sapiens 121-126 16531984-9 2006 Our results resemble those obtained after oral administration of vitamin E and are consistent with a reversible, dose-dependent inhibition of 5-Lox by omega-3. Fatty Acids, Omega-3 151-158 lysyl oxidase Homo sapiens 144-147 16938806-1 2006 BACKGROUND: Intake of n-3 polyunsaturated fatty acids (n-3 PUFA) either from natural sources or dietary supplementation is inversely associated with atherothrombosis. Fatty Acids, Omega-3 22-53 pumilio RNA binding family member 3 Homo sapiens 59-63 16194618-0 2006 CDK1-cyclin B1 mediates the inhibition of proliferation induced by omega-3 fatty acids in MDA-MB-231 breast cancer cells. Fatty Acids, Omega-3 67-86 cyclin dependent kinase 1 Homo sapiens 0-4 16194618-0 2006 CDK1-cyclin B1 mediates the inhibition of proliferation induced by omega-3 fatty acids in MDA-MB-231 breast cancer cells. Fatty Acids, Omega-3 67-86 cyclin B1 Homo sapiens 5-14 16194618-9 2006 Upon omega-3 fatty acids treatment, cyclin B1 phosphorylation was inhibited and the expression of the cell division cycle 25C phosphatase, which dephosphorylates cyclin-dependent kinase 1, was decreased. Fatty Acids, Omega-3 5-24 cyclin B1 Homo sapiens 36-45 16194618-9 2006 Upon omega-3 fatty acids treatment, cyclin B1 phosphorylation was inhibited and the expression of the cell division cycle 25C phosphatase, which dephosphorylates cyclin-dependent kinase 1, was decreased. Fatty Acids, Omega-3 5-24 cyclin dependent kinase 1 Homo sapiens 162-187 16194618-10 2006 We conclude that the anti-proliferative effect of omega-3 fatty acids occurs via the regulation of the cyclin-dependent kinase 1-cyclin B1 complex. Fatty Acids, Omega-3 50-69 cyclin dependent kinase 1 Homo sapiens 103-128 16194618-10 2006 We conclude that the anti-proliferative effect of omega-3 fatty acids occurs via the regulation of the cyclin-dependent kinase 1-cyclin B1 complex. Fatty Acids, Omega-3 50-69 cyclin B1 Homo sapiens 129-138 16234304-8 2006 Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Fatty Acids, Omega-3 6-21 interleukin 6 Homo sapiens 49-53 16234304-8 2006 Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Fatty Acids, Omega-3 6-21 interleukin 1 receptor antagonist Homo sapiens 67-73 16234304-8 2006 Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Fatty Acids, Omega-3 6-21 tumor necrosis factor Homo sapiens 91-99 16234304-8 2006 Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Fatty Acids, Omega-3 6-21 interleukin 6 receptor Homo sapiens 131-136 16234304-8 2006 Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Fatty Acids, Omega-3 6-21 interleukin 10 Homo sapiens 153-158 16234304-8 2006 Total n-3 fatty acids were associated with lower IL-6 (P = 0.005), IL-1ra (P = 0.004), and TNFalpha (P = 0.040) and higher soluble IL-6r (P < 0.001), IL-10 (P = 0.024), and TGFbeta (P = 0.0012). Fatty Acids, Omega-3 6-21 transforming growth factor beta 1 Homo sapiens 176-183 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 interleukin 6 Homo sapiens 166-170 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 interleukin 1 receptor antagonist Homo sapiens 172-178 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 tumor necrosis factor Homo sapiens 180-188 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 C-reactive protein Homo sapiens 190-208 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 interleukin 6 receptor Homo sapiens 265-270 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 interleukin 10 Homo sapiens 272-277 16234304-12 2006 CONCLUSIONS: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers (IL-6, IL-1ra, TNFalpha, C-reactive protein) and higher levels of antiinflammatory markers (soluble IL-6r, IL-10, TGFbeta) independent of confounders. Fatty Acids, Omega-3 73-88 transforming growth factor beta 1 Homo sapiens 279-286 16611404-10 2006 Our results provide evidence that prostate tumors can be modulated by the manipulation of omega-6:omega-3 ratios through diet and that the omega-3 fatty acid SDA [precursor of eicosapentaenoic acid (EPA)] promotes apoptosis and decreases proliferation in cancer cells, causing decreased PSA doubling time, compared to omega-6 LA fatty acid, likely by competing with the enzymes of LA and AA pathways, namely, 15-LO-1 and cyclooxygenases (COXs). Fatty Acids, Omega-3 139-157 kallikrein B, plasma 1 Mus musculus 287-290 16455329-2 2006 We hypothesize that omega-3FA modulates up-regulation of hypothalamic orexigenic neuropeptide Y (NPY) and down-regulation of anorexigenic alpha melanocyte-stimulating hormone (alpha-MSH) and serotonin 1B receptors (5-HT(1B)-receptors) in tumor-bearing rats. Fatty Acids, Omega-3 20-29 proopiomelanocortin Rattus norvegicus 176-185 16455329-8 2006 Omega-3FA diet in anorexia (TB-omega-3FA vs R-omega-3FA) produced similar qualitative changes of NPY (22% increase) and alpha-MSH (31% decrease) in ARC, with concomitant decrease of 37% in 5-HT(1B)-receptors in PVN, confirming the influence of omega-3FA on the hypothalamic food intake modulators. Fatty Acids, Omega-3 31-40 neuropeptide Y Rattus norvegicus 97-100 16455329-8 2006 Omega-3FA diet in anorexia (TB-omega-3FA vs R-omega-3FA) produced similar qualitative changes of NPY (22% increase) and alpha-MSH (31% decrease) in ARC, with concomitant decrease of 37% in 5-HT(1B)-receptors in PVN, confirming the influence of omega-3FA on the hypothalamic food intake modulators. Fatty Acids, Omega-3 31-40 proopiomelanocortin Rattus norvegicus 120-129 16154718-10 2006 In conclusion, PPARalpha and PPARdelta function in the response of bovine endometrium to growth hormone and long chain omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 119-154 peroxisome proliferator activated receptor alpha Bos taurus 15-24 16397791-1 2006 AIMS/HYPOTHESIS: Diets rich in n-3 polyunsaturated fatty acids, namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against insulin resistance and obesity in rodents and increase insulin sensitivity in healthy humans. Fatty Acids, Omega-3 31-62 insulin Homo sapiens 147-154 16441943-3 2006 An important question is whether dietary intake of the precursor n-3 fatty acid, alpha-linolenic acid (alphaLNA), can provide sufficient amounts of tissue EPA and DHA by conversion through the n-3 PUFA elongation-desaturation pathway. Fatty Acids, Omega-3 65-79 pumilio RNA binding family member 3 Homo sapiens 197-201 16455329-2 2006 We hypothesize that omega-3FA modulates up-regulation of hypothalamic orexigenic neuropeptide Y (NPY) and down-regulation of anorexigenic alpha melanocyte-stimulating hormone (alpha-MSH) and serotonin 1B receptors (5-HT(1B)-receptors) in tumor-bearing rats. Fatty Acids, Omega-3 20-29 neuropeptide Y Rattus norvegicus 97-100 16455329-2 2006 We hypothesize that omega-3FA modulates up-regulation of hypothalamic orexigenic neuropeptide Y (NPY) and down-regulation of anorexigenic alpha melanocyte-stimulating hormone (alpha-MSH) and serotonin 1B receptors (5-HT(1B)-receptors) in tumor-bearing rats. Fatty Acids, Omega-3 20-29 proopiomelanocortin Rattus norvegicus 138-174 16493496-0 2006 Long term influence of regular intake of high dose n-3 fatty acids on CD40-ligand, pregnancy-associated plasma protein A and matrix metalloproteinase-9 following acute myocardial infarction. Fatty Acids, Omega-3 51-66 matrix metallopeptidase 9 Homo sapiens 70-151 16319686-8 2006 Since lipid constitution of cell membranes affects surface expression of adhesion molecules, the above findings could account for earlier observations that omega-3 fatty acids reduce P-selectin expression and reduce the frequency of sickle cell crisis. Fatty Acids, Omega-3 156-175 selectin P Homo sapiens 183-193 16249288-10 2006 RESULTS: Expression of PLA2G2A and PLA2G5, the main placenta phospholipases, was greater (P < 0.05) in placenta of obese compared with control neonates and was associated with increased 20:3 and 20:5 omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 203-238 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 23-30 17017909-10 2006 Likewise, a possible down-regulation of COX-2 by omega-3 fatty acids has been suggested. Fatty Acids, Omega-3 49-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 40-45 16222032-1 2006 Insulin induces and dietary n-3 PUFAs suppress hepatic de novo lipogenesis by controlling sterol-regulatory element binding protein-1 nuclear abundance (nSREBP-1). Fatty Acids, Omega-3 28-37 sterol regulatory element binding transcription factor 1 Rattus norvegicus 90-133 16249288-10 2006 RESULTS: Expression of PLA2G2A and PLA2G5, the main placenta phospholipases, was greater (P < 0.05) in placenta of obese compared with control neonates and was associated with increased 20:3 and 20:5 omega-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 203-238 phospholipase A2, group V Mus musculus 35-41 16249288-13 2006 CONCLUSION: Accumulation of omega-3 fatty acids through secretory PLA2 activation is associated with high neonatal adiposity. Fatty Acids, Omega-3 28-47 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 66-70 16555469-0 2006 N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland. Fatty Acids, Omega-3 0-31 FAT atypical cadherin 1 Mus musculus 60-65 16555469-3 2006 The synthesis of n-3 PUFA is achieved through the expression of the fat-1 transgene encoding for an n-3 desaturase from Caenorhabditis elegans, which utilizes n-6 PUFA as substrate. Fatty Acids, Omega-3 17-25 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 68-73 18370748-8 2006 Reduced mitochondrial oxidative phosphorylation can be partially reversed by improved diet, increased exercise, and administration of peroxisome proliferator-activated receptor-alpha agonists (omega-3 fatty acids and fibrates). Fatty Acids, Omega-3 193-212 peroxisome proliferator activated receptor alpha Homo sapiens 134-182 16500033-5 2006 Suggested mechanisms of action of omega-3 fatty acids include the downregulation of VEGF and bFGF, and the suppression of pro-angiogenic eicosanoids such as cylooxygenase-2. Fatty Acids, Omega-3 34-53 vascular endothelial growth factor A Homo sapiens 84-88 16500033-5 2006 Suggested mechanisms of action of omega-3 fatty acids include the downregulation of VEGF and bFGF, and the suppression of pro-angiogenic eicosanoids such as cylooxygenase-2. Fatty Acids, Omega-3 34-53 fibroblast growth factor 2 Homo sapiens 93-97 16437718-10 2005 This effect of omega-3 fatty acid modulation is significantly more marked in UC compared with CD and is accompanied by both a reduction of IL-1beta and increase of IL-1ra. Fatty Acids, Omega-3 15-33 interleukin 1 receptor antagonist Homo sapiens 164-170 16898866-17 2006 Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels. Fatty Acids, Omega-3 48-67 cytokinin dehydrogenase 1 Zea mays 232-237 16898866-17 2006 Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels. Fatty Acids, Omega-3 48-66 cytokinin dehydrogenase 1 Zea mays 232-237 16608011-4 2006 Probably, the most interesting prescription of omega-3 supplementations would benefit to the patients after myocardial infarction, in addition to drugs that have proved their efficacy (aspirine, beta-blocker statin and ACE inhibitor). Fatty Acids, Omega-3 47-54 angiotensin I converting enzyme Homo sapiens 219-222 16399491-9 2006 A significant negative correlation was found between plasma CETP activity and MUFA of plasma phospholipids or free PUFA (P = 0.032), especially with omega3-fatty acids (P = 0.001). Fatty Acids, Omega-3 149-167 cholesteryl ester transfer protein Homo sapiens 60-64 16876587-13 2006 Supplementation of tumor bearing rats with omega-3 fatty acid vs. control diet delayed the appearance of tumor, reduced tumor-growth rate and volume, negated onset of anorexia, increased body weight, decreased cytokines production and increased expression of NPY and decreased alpha-melanocyte-stimulating hormone (alpha-MSH) in hypothalamic nuclei. Fatty Acids, Omega-3 43-61 neuropeptide Y Rattus norvegicus 259-262 16876587-13 2006 Supplementation of tumor bearing rats with omega-3 fatty acid vs. control diet delayed the appearance of tumor, reduced tumor-growth rate and volume, negated onset of anorexia, increased body weight, decreased cytokines production and increased expression of NPY and decreased alpha-melanocyte-stimulating hormone (alpha-MSH) in hypothalamic nuclei. Fatty Acids, Omega-3 43-61 proopiomelanocortin Rattus norvegicus 277-313 16876587-13 2006 Supplementation of tumor bearing rats with omega-3 fatty acid vs. control diet delayed the appearance of tumor, reduced tumor-growth rate and volume, negated onset of anorexia, increased body weight, decreased cytokines production and increased expression of NPY and decreased alpha-melanocyte-stimulating hormone (alpha-MSH) in hypothalamic nuclei. Fatty Acids, Omega-3 43-61 proopiomelanocortin Rattus norvegicus 315-324 16489323-5 2005 Moreover, an increase in the eicosapentaenoic acid (EPA) intake leads to a reduction in the production of inflammatory cytokines (interleukin 1, 2, 6 and tumor necrosis factor); so, it is important to use omega-3 in chronic inflammatory diseases, as the rheumatoid arthritis. Fatty Acids, Omega-3 205-212 tumor necrosis factor Homo sapiens 130-175 16317153-7 2005 The high-(n-3) PUFA diet had opposite effects on these 2 key biomarkers and increased phospho-Akt levels, a survival factor. Fatty Acids, Omega-3 10-19 AKT serine/threonine kinase 1 Rattus norvegicus 94-97 16255998-5 2005 In contrast, unsaturated fats, and particularly omega-3 fatty acids, have the combined benefits of lowering serum cholesterol and raising high-density lipoprotein, as well as favorable effects on insulin resistance and inflammation; they also lower cardiovascular events in high-risk patients. Fatty Acids, Omega-3 48-67 insulin Homo sapiens 196-203 16043214-7 2005 CONCLUSION: These data suggest that, under the influence of OM-3FAs, there are definitive growth suppressive mechanisms at work and that the biologic effects of OM-3FAs may in part be mediated by the p53 status. Fatty Acids, Omega-3 161-168 transformation related protein 53, pseudogene Mus musculus 200-203 16205884-1 2005 AIMS/HYPOTHESIS: Intake of n-3 polyunsaturated fatty acids reduces adipose tissue mass, preferentially in the abdomen. Fatty Acids, Omega-3 27-58 WD and tetratricopeptide repeats 1 Mus musculus 67-74 16205884-12 2005 The expression of Ppargc1a and Nrf1 was also stimulated by n-3 polyunsaturated fatty acids in 3T3-L1 cells. Fatty Acids, Omega-3 59-90 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 18-26 16205884-12 2005 The expression of Ppargc1a and Nrf1 was also stimulated by n-3 polyunsaturated fatty acids in 3T3-L1 cells. Fatty Acids, Omega-3 59-90 nuclear respiratory factor 1 Mus musculus 31-35 16249517-1 2005 PURPOSE: Docosahexaenoic acid (DHA(22:6n3)), the principal n3-polyunsaturated fatty acid (PUFA) in the retina, has been shown to have a pronounced anti-inflammatory effect in numerous in vivo and in vitro studies. Fatty Acids, Omega-3 59-88 pumilio RNA binding family member 3 Homo sapiens 90-94 15894339-8 2005 In addition, the stimulation of AOX was highly associated with the content of long chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in hepatic microsome. Fatty Acids, Omega-3 89-97 acyl-CoA oxidase 1 Rattus norvegicus 32-35 16277123-6 2005 RESULTS: Plasma omega-3 FA concentrations were highly correlated with dietary omega-3 FAs and HDL levels and inversely correlated with plasma levels of insulin, 2-h insulin (OGTT), HOMI-IR, 2-h glucose (OGTT), triglyceride levels and diastolic blood pressure. Fatty Acids, Omega-3 16-26 insulin Homo sapiens 152-159 16277123-6 2005 RESULTS: Plasma omega-3 FA concentrations were highly correlated with dietary omega-3 FAs and HDL levels and inversely correlated with plasma levels of insulin, 2-h insulin (OGTT), HOMI-IR, 2-h glucose (OGTT), triglyceride levels and diastolic blood pressure. Fatty Acids, Omega-3 16-26 insulin Homo sapiens 165-172 16277123-7 2005 CONCLUSIONS: High consumption of omega-3 FAs positively affects components of the MS, insulin sensitivity and glucose tolerance. Fatty Acids, Omega-3 33-44 insulin Homo sapiens 86-93 16265778-0 2005 Insulin-like growth factors (IGFs) and IGF binding proteins in active Crohn"s disease treated with omega-3 or omega-6 fatty acids and corticosteroids. Fatty Acids, Omega-3 99-106 insulin Homo sapiens 0-7 23105526-5 2005 After substitution of omega-3 fatty acid, a significant reduction of fasting plasma insulin levels in both group 1 (29%) and group 2 (22.8%) was observed (p<0.001). Fatty Acids, Omega-3 22-40 insulin Homo sapiens 84-91 16040805-2 2005 Here, we demonstrate a mechanism where membrane alteration by the n-3 fatty acid status affects Akt signaling, impacting neuronal survival. Fatty Acids, Omega-3 66-80 AKT serine/threonine kinase 1 Homo sapiens 96-99 16040805-3 2005 Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid highly enriched in neuronal membranes, promotes neuronal survival by facilitating membrane translocation/activation of Akt through its capacity to increase phosphatidylserine (PS), the major acidic phospholipid in cell membranes. Fatty Acids, Omega-3 31-61 AKT serine/threonine kinase 1 Homo sapiens 181-184 16101743-3 2005 Here, we show that in transgenic mice overexpressing the human AD gene APPswe (Tg2576), safflower oil-induced n-3 PFA deficiency caused a decrease in N-methyl-D-aspartate (NMDA) receptor subunits, NR2A and NR2B, in the cortex and hippocampus with no loss of the presynaptic markers, synaptophysin and synaptosomal-associated protein 25 (SNAP-25). Fatty Acids, Omega-3 110-117 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 206-210 16101743-7 2005 Most interestingly, n-3 PFA deficiency dramatically increased levels of protein fragments, corresponding to caspase/calpain-cleaved fodrin and gelsolin in Tg2576 mice. Fatty Acids, Omega-3 20-27 gelsolin Mus musculus 143-151 16288576-0 2005 [Relation between intake of omega 3 fatty acids and CD4 count in patients with HIV infection: a transversal study]. Fatty Acids, Omega-3 28-47 CD4 molecule Homo sapiens 52-55 16288576-12 2005 CONCLUSION: In patients with HIV infection, dietary intake of omega 3 fatty acids increase CD4 count. Fatty Acids, Omega-3 62-81 CD4 molecule Homo sapiens 91-94 15986129-7 2005 Cells incubated with omega-3 fatty acids demonstrated decreased Akt phosphorylation, as well as NFkappaB DNA binding activity (p<0.05). Fatty Acids, Omega-3 21-40 AKT serine/threonine kinase 1 Homo sapiens 64-67 15986129-8 2005 The results of this study indicate that omega-3 fatty acids decrease cell proliferation and induce apoptotic cell death in human breast cancer cells, possibly by decreasing signal transduction through the Akt/NFkappaB cell survival pathway. Fatty Acids, Omega-3 40-59 AKT serine/threonine kinase 1 Homo sapiens 205-208 15930965-2 2005 RECENT FINDINGS: Recent studies have demonstrated that omega-3 fatty acids modulate changes in the concentrations and actions of several orexigenic and anorexigenic neuropeptides in the brain, including neuropeptide Y, alpha-melanocyte stimulating hormone and the neurotransmitters serotonin and dopamine. Fatty Acids, Omega-3 55-74 neuropeptide Y Homo sapiens 203-217 15930965-2 2005 RECENT FINDINGS: Recent studies have demonstrated that omega-3 fatty acids modulate changes in the concentrations and actions of several orexigenic and anorexigenic neuropeptides in the brain, including neuropeptide Y, alpha-melanocyte stimulating hormone and the neurotransmitters serotonin and dopamine. Fatty Acids, Omega-3 55-74 proopiomelanocortin Homo sapiens 219-255 15845652-2 2005 We hypothesized that the direction of the association between the (CCND1) G870A-polymorphism and breast cancer risk may be modified by dietary and genetic factors influencing the oxidant-antioxidant balance, such as a dietary pattern with a high intake of n-6 fatty acids and a low intake of n-3 fatty acids, or a genetic profile that is deficient in glutathione S-transferases. Fatty Acids, Omega-3 292-307 cyclin D1 Homo sapiens 67-72 16054558-0 2005 The effects of consumption of omega3 fatty acid-enriched eggs on insulin and CRP. Fatty Acids, Omega-3 30-47 C-reactive protein Homo sapiens 77-80 16456721-4 2005 By similar mechanisms, omega-3 fatty acids have been recently shown to reduce gene expression of cyclooxygenase-2, an inflammatory gene involved, through the activation of some metalloproteinases, in plaque angiogenesis and plaque rupture. Fatty Acids, Omega-3 23-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 97-113 16456726-0 2005 From fat to fat-1: a tale of omega-3 fatty acids. Fatty Acids, Omega-3 29-48 FAT atypical cadherin 1 Homo sapiens 12-17 15927553-3 2005 We hypothesize that, in cancer anorexia, omega-3FA is associated with quantitative reversal of hypothalamic NPY, alpha-MSH, and serotonin receptor (5-HT(1B)-receptor) enhancing FI. Fatty Acids, Omega-3 41-50 neuropeptide Y Rattus norvegicus 108-111 15927553-3 2005 We hypothesize that, in cancer anorexia, omega-3FA is associated with quantitative reversal of hypothalamic NPY, alpha-MSH, and serotonin receptor (5-HT(1B)-receptor) enhancing FI. Fatty Acids, Omega-3 41-50 proopiomelanocortin Rattus norvegicus 113-122 15650121-1 2005 Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, has been shown to stimulate leptin mRNA expression and secretion in 3T3-L1 cells. Fatty Acids, Omega-3 40-71 leptin Mus musculus 101-107 16054080-0 2005 Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain. Fatty Acids, Omega-3 56-87 leptin Homo sapiens 37-43 15772428-0 2005 Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. Fatty Acids, Omega-3 8-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-63 15772428-3 2005 We investigated the effects of omega-3 PUFA on the expression and function of COX-2 in 70W, a human melanoma cell line that metastasizes to the brain in nude mice. Fatty Acids, Omega-3 31-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 78-83 15899837-0 2005 Omega-3 polyunsaturated fatty acids regulate syndecan-1 expression in human breast cancer cells. Fatty Acids, Omega-3 0-35 syndecan 1 Homo sapiens 45-55 16054080-2 2005 We examined the role of n-3 polyunsaturated fatty acid (PUFA) in peripheral leptin resistance. Fatty Acids, Omega-3 24-54 leptin Homo sapiens 76-82 16054080-7 2005 We conclude that n-3 PUFA induces peripheral leptin resistance via an increase in the expression of hypothalamic occludin, reducing paracellular transport of leptin into the brain. Fatty Acids, Omega-3 17-25 leptin Homo sapiens 45-51 16054080-7 2005 We conclude that n-3 PUFA induces peripheral leptin resistance via an increase in the expression of hypothalamic occludin, reducing paracellular transport of leptin into the brain. Fatty Acids, Omega-3 17-25 occludin Homo sapiens 113-121 16054080-7 2005 We conclude that n-3 PUFA induces peripheral leptin resistance via an increase in the expression of hypothalamic occludin, reducing paracellular transport of leptin into the brain. Fatty Acids, Omega-3 17-25 leptin Homo sapiens 158-164 15867269-0 2005 Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone. Fatty Acids, Omega-3 8-41 erb-b2 receptor tyrosine kinase 2 Mus musculus 50-55 15843537-6 2005 In contrast, an n-3 polyunsaturated fatty acid, docosahexaenoic acid, inhibits TLR4 agonist (LPS)-induced up-regulation of the costimulatory molecules, MHC class II, and cytokine production. Fatty Acids, Omega-3 16-46 toll like receptor 4 Homo sapiens 79-83 15867269-0 2005 Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone. Fatty Acids, Omega-3 8-41 erb-b2 receptor tyrosine kinase 2 Mus musculus 56-59 15867269-10 2005 Further studies focusing on the mechanisms by which (n-3) fatty acids suppress HER-2/neu signaling pathways involved in the pathogenesis of breast cancer are warranted. Fatty Acids, Omega-3 52-69 erb-b2 receptor tyrosine kinase 2 Mus musculus 79-84 15867269-10 2005 Further studies focusing on the mechanisms by which (n-3) fatty acids suppress HER-2/neu signaling pathways involved in the pathogenesis of breast cancer are warranted. Fatty Acids, Omega-3 52-69 erb-b2 receptor tyrosine kinase 2 Homo sapiens 85-88 15654818-0 2005 Dietary n-3 polyunsaturated fatty acids suppress splenic CD4(+) T cell function in interleukin (IL)-10(-/-) mice. Fatty Acids, Omega-3 8-39 CD4 antigen Mus musculus 57-60 16187707-3 2005 It has been demonstrated that consumption of n-6 and n-3 PUFAs decreases blood triglycerides by increasing fatty acid oxidation through activation of PPARalpha or by reducing the activation of SREBP-1 inhibiting lipogenesis. Fatty Acids, Omega-3 53-62 peroxisome proliferator activated receptor alpha Homo sapiens 150-159 16187707-3 2005 It has been demonstrated that consumption of n-6 and n-3 PUFAs decreases blood triglycerides by increasing fatty acid oxidation through activation of PPARalpha or by reducing the activation of SREBP-1 inhibiting lipogenesis. Fatty Acids, Omega-3 53-62 sterol regulatory element binding transcription factor 1 Homo sapiens 193-200 15637134-10 2005 Among nonsmokers, the percentages of palmitic acid (P = 0.01) and omega-3 fatty acids contributed 8% and 7%, respectively, to adiponectin variance. Fatty Acids, Omega-3 66-85 adiponectin, C1Q and collagen domain containing Homo sapiens 126-137 15654818-0 2005 Dietary n-3 polyunsaturated fatty acids suppress splenic CD4(+) T cell function in interleukin (IL)-10(-/-) mice. Fatty Acids, Omega-3 8-39 interleukin 10 Mus musculus 83-102 15654818-1 2005 Our laboratory has demonstrated that down-regulation of proliferation and cytokine synthesis by CD4(+) T cells in mice fed diets rich in n-3 polyunsaturated fatty acids (PUFA) is highly dependent on the involvement of the co-stimulatory molecule, CD28. Fatty Acids, Omega-3 137-168 CD4 antigen Mus musculus 96-99 15654818-1 2005 Our laboratory has demonstrated that down-regulation of proliferation and cytokine synthesis by CD4(+) T cells in mice fed diets rich in n-3 polyunsaturated fatty acids (PUFA) is highly dependent on the involvement of the co-stimulatory molecule, CD28. Fatty Acids, Omega-3 137-168 CD28 antigen Mus musculus 247-251 15639338-1 2005 The proliferative and apoptotic response to TNF-alpha and anti-Fas antibody (CH-11) in human colon adenocarcinoma HT-29 cells was modulated by pretreatment with arachidonic (AA, 20:4, n-6) or docosahexaenoic (DHA, 22:6, n-3) fatty acids, which alone increased reactive oxygen species production and lipid peroxidation, and decreased the S-phase of the cell cycle. Fatty Acids, Omega-3 220-236 tumor necrosis factor Homo sapiens 44-53 15633108-0 2005 Omega-3 polyunsaturated fatty acids impair in vivo interferon- gamma responsiveness via diminished receptor signaling. Fatty Acids, Omega-3 0-35 interferon gamma Mus musculus 51-68 15629236-1 2005 We demonstrate in this study that the n-3 polyunsaturated fatty acids derived from fish oil, namely, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), can increase levels of tissue inhibitors of metalloproteinase-1 (TIMP-1) in the renal cell carcinoma cell line caki-1 by 26% and 17.42% respectively. Fatty Acids, Omega-3 38-69 TIMP metallopeptidase inhibitor 1 Homo sapiens 225-231 16050054-14 2005 RESULTS: After 8 weeks, omega-3 FA + policosanol 5 and 10 mg/day, but not omega-3 FA + placebo, significantly reduced LDL-C by 21.1% and 24.4%, respectively (both p < 0.0001). Fatty Acids, Omega-3 24-34 component of oligomeric golgi complex 2 Homo sapiens 118-123 16050054-18 2005 The proportion of randomised patients in the omega-3 FA + policosanol 5 or 10 mg/day groups that achieved LDL-C targets or reductions 15% was significantly greater than in the omega-3 FA + placebo group (p < 0.001). Fatty Acids, Omega-3 45-55 component of oligomeric golgi complex 2 Homo sapiens 106-111 16050054-19 2005 Combined therapy with omega-3 FA + policosanol 5 or 10 mg/day resulted in significantly greater changes in LDL-C, TC and HDL-C than treatment with omega-3 FA + placebo, but did not modify the TG response compared with the omega-3 FA + placebo group. Fatty Acids, Omega-3 22-32 component of oligomeric golgi complex 2 Homo sapiens 107-112 16050054-22 2005 CONCLUSIONS: Policosanol 5 or 10 mg/day administered concomitantly with omega-3 FA 1 g/day improved LDL-C, TC and HDL-C, maintained the reduction in TG attributable to omega-3 FA monotherapy, and was well tolerated. Fatty Acids, Omega-3 72-82 component of oligomeric golgi complex 2 Homo sapiens 100-105 15591305-0 2005 Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle. Fatty Acids, Omega-3 9-24 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 70-73 16122552-0 2005 Varying the ratio of dietary n-6/n-3 polyunsaturated fatty acid alters the tendency to thrombosis and progress of atherosclerosis in apoE-/- LDLR-/- double knockout mouse. Fatty Acids, Omega-3 33-63 apolipoprotein E Mus musculus 133-137 15830643-11 2005 CONCLUSIONS: The results of the present study indicate that celecoxib and omega-3 fatty acid, when used individually, show a rather partial effect on the control of the analyzed mediators, but when combined they show a synergic effect and provide significant reductions in the gingival tissue levels of PGE2, PGF2alpha, LTB4, and PAF in LPS-induced experimental periodontitis. Fatty Acids, Omega-3 74-92 PCNA clamp associated factor Rattus norvegicus 330-333 16122552-0 2005 Varying the ratio of dietary n-6/n-3 polyunsaturated fatty acid alters the tendency to thrombosis and progress of atherosclerosis in apoE-/- LDLR-/- double knockout mouse. Fatty Acids, Omega-3 33-63 low density lipoprotein receptor Mus musculus 141-145 15732866-1 2004 BACKGROUND: The aim of the present study was 1) to evaluate the possible effects of therapeutic usage of omega-3 fatty acid on the gingival tissue levels of prostaglandin E2 (PGE2), prostaglandin F2alpha (PGF2alpha), platelet activating factor (PAF), and leukotriene B4 (LTB4) in endotoxin-induced periodontitis in rats and 2) to investigate whether prophylactic usage provides any additional benefits to therapeutic doses of omega-3 fatty acid. Fatty Acids, Omega-3 105-123 PCNA clamp associated factor Rattus norvegicus 245-248 15732866-14 2004 CONCLUSIONS: Therapeutic omega-3 fatty acid significantly reduced the gingival tissue levels of PGE2, PGF2alpha, LTB4, and PAF in experimental periodontitis. Fatty Acids, Omega-3 25-43 PCNA clamp associated factor Rattus norvegicus 123-126 22062543-4 2004 The outdoor environment resulted in a slightly higher level of n-3 polyunsaturated FA (PUFA) in muscle PL and NL of entire males compared with females and castrated males. Fatty Acids, Omega-3 63-85 Polyunsaturated fatty acid percentage Sus scrofa 87-91 15522828-11 2004 These results suggest that the transcription level of ACMSD is modulated by polyunsaturated fatty acids, and suppressive potency of ACMSD mRNA is n-3 fatty acid family>linoleic acid (n-6 fatty acid)>saturated fatty acid. Fatty Acids, Omega-3 146-160 aminocarboxymuconate semialdehyde decarboxylase Rattus norvegicus 132-137 15522828-11 2004 These results suggest that the transcription level of ACMSD is modulated by polyunsaturated fatty acids, and suppressive potency of ACMSD mRNA is n-3 fatty acid family>linoleic acid (n-6 fatty acid)>saturated fatty acid. Fatty Acids, Omega-3 146-160 aminocarboxymuconate semialdehyde decarboxylase Rattus norvegicus 54-59 15339646-3 2004 Here, we report that reduction of dietary n-3 PFA in an AD mouse model resulted in 80%-90% losses of the p85alpha subunit of phosphatidylinositol 3-kinase and the postsynaptic actin-regulating protein drebrin, as in AD brain. Fatty Acids, Omega-3 42-49 drebrin 1 Mus musculus 201-208 15256483-5 2004 Therefore, we hypothesized that individuals possessing the low activity genotypes of GSTM1, GSTT1 and/or GSTP1 (i.e. the GSTM1 null, GSTT1 null and GSTP1 AB/BB genotypes, respectively) may exhibit a stronger marine n-3 fatty acid-breast cancer association than their high activity counterparts. Fatty Acids, Omega-3 215-229 glutathione S-transferase mu 1 Homo sapiens 85-90 15256483-5 2004 Therefore, we hypothesized that individuals possessing the low activity genotypes of GSTM1, GSTT1 and/or GSTP1 (i.e. the GSTM1 null, GSTT1 null and GSTP1 AB/BB genotypes, respectively) may exhibit a stronger marine n-3 fatty acid-breast cancer association than their high activity counterparts. Fatty Acids, Omega-3 215-229 glutathione S-transferase theta 1 Homo sapiens 92-97 15256483-5 2004 Therefore, we hypothesized that individuals possessing the low activity genotypes of GSTM1, GSTT1 and/or GSTP1 (i.e. the GSTM1 null, GSTT1 null and GSTP1 AB/BB genotypes, respectively) may exhibit a stronger marine n-3 fatty acid-breast cancer association than their high activity counterparts. Fatty Acids, Omega-3 215-229 glutathione S-transferase pi 1 Homo sapiens 105-110 15672655-0 2004 [Il-10 expression is involved in the regulation of the immune response by omega 3 fatty acids]. Fatty Acids, Omega-3 74-93 interleukin 10 Mus musculus 1-6 15672635-0 2004 Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. Fatty Acids, Omega-3 8-27 brain-derived neurotrophic factor Rattus norvegicus 38-42 15672635-7 2004 Supplementation of omega-3 fatty acids in the diet counteracted all of the studied effects of FPI, that is, normalized levels of BDNF and associated synapsin I and CREB, reduced oxidative damage, and counteracted learning disability. Fatty Acids, Omega-3 19-38 brain-derived neurotrophic factor Rattus norvegicus 129-133 15672635-7 2004 Supplementation of omega-3 fatty acids in the diet counteracted all of the studied effects of FPI, that is, normalized levels of BDNF and associated synapsin I and CREB, reduced oxidative damage, and counteracted learning disability. Fatty Acids, Omega-3 19-38 synapsin I Rattus norvegicus 149-159 15672635-7 2004 Supplementation of omega-3 fatty acids in the diet counteracted all of the studied effects of FPI, that is, normalized levels of BDNF and associated synapsin I and CREB, reduced oxidative damage, and counteracted learning disability. Fatty Acids, Omega-3 19-38 cAMP responsive element binding protein 1 Rattus norvegicus 164-168 15483173-6 2004 Concentrations of n-3 fatty acids and the n-6 to n-3 fatty acids ratio in milk were the highest and lowest, respectively, for cows fed whole flaxseed. Fatty Acids, Omega-3 18-33 Weaning weight-maternal milk Bos taurus 74-78 15483173-6 2004 Concentrations of n-3 fatty acids and the n-6 to n-3 fatty acids ratio in milk were the highest and lowest, respectively, for cows fed whole flaxseed. Fatty Acids, Omega-3 49-64 Weaning weight-maternal milk Bos taurus 74-78 15754841-8 2004 It is possible that a marginal deficiency of long-chain PUFAs, especially n-3 fatty acids, due to poor dietary intake during the critical period of brain growth and development in the fetus, and later in the infant and also possibly in the child, adolescent and adult may enhance the release of tumor necrosis factor-alpha (TNF-alpha) interleukin (IL)-1, 2 and 6 and cause neuronal dysfunction. Fatty Acids, Omega-3 74-89 tumor necrosis factor Homo sapiens 295-322 15157896-0 2004 Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males. Fatty Acids, Omega-3 25-43 interleukin 6 receptor Homo sapiens 66-88 15458276-7 2004 Supplementation with n-3 FA and a low n-6 FA intake decreased serum sTNF-R p55 and CRP levels in patients with RA. Fatty Acids, Omega-3 21-27 C-reactive protein Homo sapiens 83-86 15298768-7 2004 Increased plasma membrane concentrations of n-3 FA, such as DHA, might exert regulatory effects on PKC by increasing membrane fluidity, causing changes in CYP2E1, elevating levels of LPO, or producing oxidative stress. Fatty Acids, Omega-3 44-50 proline rich transmembrane protein 2 Homo sapiens 99-102 15298768-7 2004 Increased plasma membrane concentrations of n-3 FA, such as DHA, might exert regulatory effects on PKC by increasing membrane fluidity, causing changes in CYP2E1, elevating levels of LPO, or producing oxidative stress. Fatty Acids, Omega-3 44-50 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 155-161 15231516-0 2004 Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway. Fatty Acids, Omega-3 9-28 peroxisome proliferator activated receptor alpha Mus musculus 64-73 15231516-1 2004 OBJECTIVE: The aim of this study was to determine the effects of oxidized versus native omega-3 fatty acids on the endothelial expression of chemokines MCP-1 and IL-8, and, if effective in inhibiting chemokine expression, to determine the mechanism for the inhibition of chemokine expression. Fatty Acids, Omega-3 88-107 chemokine (C-C motif) ligand 2 Mus musculus 152-157 15231516-1 2004 OBJECTIVE: The aim of this study was to determine the effects of oxidized versus native omega-3 fatty acids on the endothelial expression of chemokines MCP-1 and IL-8, and, if effective in inhibiting chemokine expression, to determine the mechanism for the inhibition of chemokine expression. Fatty Acids, Omega-3 88-107 chemokine (C-X-C motif) ligand 15 Mus musculus 162-166 15207530-9 2004 As a result, n-3 PUFA may regulate the metabolic function of liver effectively by increasing HK, G6PD, 6PGD, LDH, and MDH enzyme activities of rat liver when added in enough amounts to the regular diet. Fatty Acids, Omega-3 13-21 glucose-6-phosphate dehydrogenase Rattus norvegicus 97-101 15226473-4 2004 C-reactive protein (CRP) levels were 29% lower among those in the highest quintile of total (n-3) fatty acids, compared with the lowest quintile; interleukin-6 (IL-6) levels were 23% lower, E-selectin levels 10% lower, soluble intracellular adhesion molecule (sICAM-1) levels 7% lower, and soluble vascular adhesion molecule (sVCAM-1) levels 8% lower. Fatty Acids, Omega-3 92-109 C-reactive protein Homo sapiens 0-18 15226473-4 2004 C-reactive protein (CRP) levels were 29% lower among those in the highest quintile of total (n-3) fatty acids, compared with the lowest quintile; interleukin-6 (IL-6) levels were 23% lower, E-selectin levels 10% lower, soluble intracellular adhesion molecule (sICAM-1) levels 7% lower, and soluble vascular adhesion molecule (sVCAM-1) levels 8% lower. Fatty Acids, Omega-3 92-109 C-reactive protein Homo sapiens 20-23 15226473-7 2004 Total (n-3) fatty acids had an inverse relation with CRP (beta = -0.44, P = 0.007), IL-6 (beta = -0.26, P = 0.009), E-selectin (beta = -0.17, P = 0.004), sICAM-1 (beta = -0.07, P = 0.02), and sVCAM-1 (beta = -0.10, P = 0.004). Fatty Acids, Omega-3 6-23 C-reactive protein Homo sapiens 53-56 15226473-7 2004 Total (n-3) fatty acids had an inverse relation with CRP (beta = -0.44, P = 0.007), IL-6 (beta = -0.26, P = 0.009), E-selectin (beta = -0.17, P = 0.004), sICAM-1 (beta = -0.07, P = 0.02), and sVCAM-1 (beta = -0.10, P = 0.004). Fatty Acids, Omega-3 6-23 interleukin 6 Homo sapiens 84-88 15226473-7 2004 Total (n-3) fatty acids had an inverse relation with CRP (beta = -0.44, P = 0.007), IL-6 (beta = -0.26, P = 0.009), E-selectin (beta = -0.17, P = 0.004), sICAM-1 (beta = -0.07, P = 0.02), and sVCAM-1 (beta = -0.10, P = 0.004). Fatty Acids, Omega-3 6-23 selectin E Homo sapiens 116-126 15462115-0 2004 Treatment of severe IgA nephropathy with omega-3 fatty acids: the effect of a "very low dose" regimen. Fatty Acids, Omega-3 41-60 IGAN1 Homo sapiens 20-35 15462115-1 2004 BACKGROUND: The effect of a "very low dose" of purified omega-3 fatty acids (PFA) in the progression of severe IgA nephropathy (IgAN) was tested, in a randomized, prospective, controlled trial. Fatty Acids, Omega-3 56-75 IGAN1 Homo sapiens 111-126 15462115-1 2004 BACKGROUND: The effect of a "very low dose" of purified omega-3 fatty acids (PFA) in the progression of severe IgA nephropathy (IgAN) was tested, in a randomized, prospective, controlled trial. Fatty Acids, Omega-3 56-75 IGAN1 Homo sapiens 128-132 15124014-2 2004 Stimulation of post-ER presecretory proteolysis (PERPP) of ApoB by n-3 polyunsaturated fatty acids has been found to result in reduced secretion of VLDL particles by hepatocytes. Fatty Acids, Omega-3 67-98 apolipoprotein B Homo sapiens 59-63 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Fatty Acids, Omega-3 29-47 interleukin 1 beta Rattus norvegicus 220-228 15175795-0 2004 The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene. Fatty Acids, Omega-3 34-52 coagulation factor VII Homo sapiens 72-94 15060086-0 2004 Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration. Fatty Acids, Omega-3 0-18 interleukin 1 beta Rattus norvegicus 113-121 14966134-5 2004 An n-3 polyunsaturated fatty acid (docosahexaenoic acid (DHA)) suppressed NFkappaB activation and cyclooxygenase-2 expression induced by the agonist for TLR2, 3, 4, 5, or 9 in a macrophage cell line (RAW264.7). Fatty Acids, Omega-3 3-33 prostaglandin-endoperoxide synthase 2 Homo sapiens 98-114 14966134-5 2004 An n-3 polyunsaturated fatty acid (docosahexaenoic acid (DHA)) suppressed NFkappaB activation and cyclooxygenase-2 expression induced by the agonist for TLR2, 3, 4, 5, or 9 in a macrophage cell line (RAW264.7). Fatty Acids, Omega-3 3-33 toll like receptor 2 Homo sapiens 153-160 15043759-4 2004 The most effective therapies for IgAN appear to be corticosteroids, ACEi, and FOS that contain a high concentration of omega 3 fatty acids. Fatty Acids, Omega-3 119-138 IGAN1 Homo sapiens 33-37 15043759-4 2004 The most effective therapies for IgAN appear to be corticosteroids, ACEi, and FOS that contain a high concentration of omega 3 fatty acids. Fatty Acids, Omega-3 119-138 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 78-81 14767877-2 2004 While both omega-3 polyunsaturated fatty acids (n3PUFA) and the lipid-soluble antioxidant alpha-tocopherol (AT) have been shown to independently have significant anti-inflammatory effects, there is paucity of data examining the effect of n3PUFA alone and in combination with AT on markers of inflammation and monocyte function. Fatty Acids, Omega-3 11-46 pumilio RNA binding family member 3 Homo sapiens 50-54 15064683-14 2004 CONCLUSIONS: Feeding n-3 fatty acids to rats with mutant rhodopsin transgenes significantly increased the levels of 22:6n-3 in ROS membranes, but had no effect on the rate of retinal degeneration. Fatty Acids, Omega-3 21-36 rhodopsin Rattus norvegicus 57-66 15068229-9 2004 Treatment with the omega-3 fatty acid 20:5, but not 18:1, enhanced insulin-stimulated NO production but failed to alter insulin-stimulated Akt activation or eNOS serine 1179 phosphorylation. Fatty Acids, Omega-3 19-37 insulin Homo sapiens 67-74 15023399-3 2004 To test the hypothesis that apoE expression is required for n-3 fatty acid-dependent regulation of serum lipid levels and hepatic fatty acid metabolism, we examined the effect of fish oil and n-3 fatty acid ethyl esters on the activity and gene expression of hepatic enzymes involved in fatty acid oxidation and synthesis using an alternative apoE-deficient mouse model with the BALB/c genetic background (BALB/c.KOR-Apoeshl). Fatty Acids, Omega-3 60-74 apolipoprotein E Mus musculus 28-32 14960319-2 2004 Using cDNA microarrays, we assessed expression levels of 1176 genes, and we found that D-site binding protein (DBP) was three-fold increased in mice on a LC omega-3 fatty acid-rich diet compared to controls. Fatty Acids, Omega-3 157-175 D site albumin promoter binding protein Mus musculus 87-109 14960319-2 2004 Using cDNA microarrays, we assessed expression levels of 1176 genes, and we found that D-site binding protein (DBP) was three-fold increased in mice on a LC omega-3 fatty acid-rich diet compared to controls. Fatty Acids, Omega-3 157-175 D site albumin promoter binding protein Mus musculus 111-114 14960319-3 2004 DBP is known to increase transcriptional level of cholesterol 7alpha-hydroxylase (C7alpha), the rate-limiting enzyme for bile acid production and cholesterol excretion, and we found that C7alpha mRNA was also up-regulated by LC omega-3 fatty acids. Fatty Acids, Omega-3 228-247 D site albumin promoter binding protein Mus musculus 0-3 14960319-3 2004 DBP is known to increase transcriptional level of cholesterol 7alpha-hydroxylase (C7alpha), the rate-limiting enzyme for bile acid production and cholesterol excretion, and we found that C7alpha mRNA was also up-regulated by LC omega-3 fatty acids. Fatty Acids, Omega-3 228-247 cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus 50-80 14756913-5 2004 Total n-3 PUFA concentration in milk fat was increased three- to fourfold by tuna-oil supplementation (8.4 to 32.0 g/kg milk fat). Fatty Acids, Omega-3 6-14 Weaning weight-maternal milk Bos taurus 32-36 14756913-5 2004 Total n-3 PUFA concentration in milk fat was increased three- to fourfold by tuna-oil supplementation (8.4 to 32.0 g/kg milk fat). Fatty Acids, Omega-3 6-14 Weaning weight-maternal milk Bos taurus 120-124 14979680-12 2003 However, according to recent studies on endothelial nitric oxide synthase (eNOS) gene polymorphisms, it is likely that only certain patients could benefit from n-3 fatty acid supplementation. Fatty Acids, Omega-3 160-174 nitric oxide synthase 3 Homo sapiens 40-73 15581413-7 2004 Future research should characterize the role of the 5-LOX pathway in comorbid cardio-cerebro-vascular and psychiatric disorders and in the therapeutic actions of dietary omega-3 fatty acids. Fatty Acids, Omega-3 170-189 arachidonate 5-lipoxygenase Homo sapiens 52-57 14612948-9 2003 These results suggest that the omega-3 fatty acid EPA perturbs the NFkappaB pathway by a novel mechanism. Fatty Acids, Omega-3 31-49 nuclear factor kappa B subunit 1 Homo sapiens 67-75 14979680-12 2003 However, according to recent studies on endothelial nitric oxide synthase (eNOS) gene polymorphisms, it is likely that only certain patients could benefit from n-3 fatty acid supplementation. Fatty Acids, Omega-3 160-174 nitric oxide synthase 3 Homo sapiens 75-79 12821543-3 2003 After adjustment for other predictors of inflammation, intake of the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was inversely associated with plasma levels of sTNF-R1 and sTNF-R2 (P=0.03 and P<0.001, respectively) and somewhat less so for C-reactive protein (P=0.08). Fatty Acids, Omega-3 69-84 C-reactive protein Homo sapiens 274-292 12844485-0 2003 Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes. Fatty Acids, Omega-3 16-31 retinoid X receptor alpha Homo sapiens 41-49 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 interleukin 1 alpha Homo sapiens 141-145 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 interleukin 6 Homo sapiens 149-153 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 C-X-C motif chemokine ligand 8 Homo sapiens 155-159 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 colony stimulating factor 2 Homo sapiens 172-178 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 intercellular adhesion molecule 1 Homo sapiens 252-286 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 intercellular adhesion molecule 1 Homo sapiens 288-294 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 phospholipase A2 group IB Homo sapiens 326-342 12915334-12 2003 In these experiments EPA was the omega-3 fatty acid responsible for improvement, with distinct effects on inhibition of cytokines formation (IL-1 to IL-6, IL-8, TFN-alpha, GM-CSF), decreased induction of proinflammatory adhesion molecules (selectines, intercellular adhesions molecule-1 (ICAM-1)), and degrading enzymes (e.g. phospholipase A2, cyclooxygenase-2, inducible NO-synthetase). Fatty Acids, Omega-3 33-51 prostaglandin-endoperoxide synthase 2 Homo sapiens 344-360 14533000-0 2003 N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis. Fatty Acids, Omega-3 0-14 interleukin 6 Homo sapiens 52-65 14533000-10 2003 Serum IL-6 levels were significantly higher in the n-6 fatty acid-rich diet group than in the n-3 fatty acid-rich group (P<0.05). Fatty Acids, Omega-3 94-108 interleukin 6 Homo sapiens 6-10 14533000-13 2003 The effects of the n-3 fatty acids were associated with blockage of mucosal IL-6 secretion. Fatty Acids, Omega-3 19-34 interleukin 6 Homo sapiens 76-80 12615711-0 2003 Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. Fatty Acids, Omega-3 87-105 nitric oxide synthase 2 Homo sapiens 14-45 12853346-7 2003 MATERIALS AND METHODS: In this study we demonstrate that the n-3 fatty acid, eicosapentaenoic acid (EPA), inhibits the kinase activity of Akt. Fatty Acids, Omega-3 61-75 AKT serine/threonine kinase 1 Homo sapiens 138-141 12854830-15 2003 Selected n-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) added in vitro caused a significant decrease in TRACP activity and TRACP+ multinuclear cell formation from BM cells compared with selected n-6 fatty acids (linoleic acid [LA] and arachidonic acid [AA]). Fatty Acids, Omega-3 9-24 acid phosphatase 5, tartrate resistant Mus musculus 134-139 12854830-15 2003 Selected n-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) added in vitro caused a significant decrease in TRACP activity and TRACP+ multinuclear cell formation from BM cells compared with selected n-6 fatty acids (linoleic acid [LA] and arachidonic acid [AA]). Fatty Acids, Omega-3 9-24 acid phosphatase 5, tartrate resistant Mus musculus 153-158 12840197-11 2003 The S and CSF diets increased (P < 0.05) the (n-3) PUFA content in hepatic triacylglyceride, cholesterol ester and phospholipid fractions. Fatty Acids, Omega-3 48-58 colony stimulating factor 2 Rattus norvegicus 10-13 12802594-4 2003 The specific localization of B-FABP, but not the other FABPs, in Kupffer cells, and its rapid decrease after LPS injection suggest the intimate involvement of B-FABP in Kupffer cells in the inflammatory reaction, probably through mediation of n-3 polyunsaturated fatty acids, which are strong binders of B-FABP. Fatty Acids, Omega-3 243-274 fatty acid binding protein 7, brain Mus musculus 29-35 12802594-4 2003 The specific localization of B-FABP, but not the other FABPs, in Kupffer cells, and its rapid decrease after LPS injection suggest the intimate involvement of B-FABP in Kupffer cells in the inflammatory reaction, probably through mediation of n-3 polyunsaturated fatty acids, which are strong binders of B-FABP. Fatty Acids, Omega-3 243-274 fatty acid binding protein 7, brain Mus musculus 159-165 12802594-4 2003 The specific localization of B-FABP, but not the other FABPs, in Kupffer cells, and its rapid decrease after LPS injection suggest the intimate involvement of B-FABP in Kupffer cells in the inflammatory reaction, probably through mediation of n-3 polyunsaturated fatty acids, which are strong binders of B-FABP. Fatty Acids, Omega-3 243-274 fatty acid binding protein 7, brain Mus musculus 159-165 12716789-6 2003 Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively. Fatty Acids, Omega-3 13-20 C-reactive protein Homo sapiens 106-124 12716789-6 2003 Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively. Fatty Acids, Omega-3 13-20 interleukin 6 Homo sapiens 145-149 12716789-13 2003 In overweight men, the ratio of saturated to omega-3 FAs (P = 0.01), but not age, sex, BMI, WHR, or smoking status, independently contributed to 17% of IL-6 variance. Fatty Acids, Omega-3 45-56 interleukin 6 Homo sapiens 152-156 12757110-10 2003 RESULTS: Phosphorylation of p44/42 and JNK/SAPK proteins of the MAPK pathways in LPS-stimulated Mpsi(s) was significantly reduced by omega-3 FA treatment compared with Mphi treated with omega-6 FA or media alone. Fatty Acids, Omega-3 133-143 mitogen-activated protein kinase 3 Mus musculus 28-31 12757110-10 2003 RESULTS: Phosphorylation of p44/42 and JNK/SAPK proteins of the MAPK pathways in LPS-stimulated Mpsi(s) was significantly reduced by omega-3 FA treatment compared with Mphi treated with omega-6 FA or media alone. Fatty Acids, Omega-3 133-143 mitogen-activated protein kinase 8 Mus musculus 39-42 12757110-10 2003 RESULTS: Phosphorylation of p44/42 and JNK/SAPK proteins of the MAPK pathways in LPS-stimulated Mpsi(s) was significantly reduced by omega-3 FA treatment compared with Mphi treated with omega-6 FA or media alone. Fatty Acids, Omega-3 133-143 mitogen-activated protein kinase 1 Mus musculus 64-68 12757110-12 2003 Omega-3 FA pretreatment inhibited AP-1 activation. Fatty Acids, Omega-3 0-10 jun proto-oncogene Mus musculus 34-38 12765846-0 2003 Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementation. Fatty Acids, Omega-3 97-111 peroxisome proliferator activated receptor gamma Homo sapiens 43-54 12765846-2 2003 The objective of the present study was to investigate the influence of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene on serum lipid and lipoprotein responses to n-3 fatty acid supplementation. Fatty Acids, Omega-3 217-231 peroxisome proliferator activated receptor gamma Homo sapiens 104-153 12765846-2 2003 The objective of the present study was to investigate the influence of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene on serum lipid and lipoprotein responses to n-3 fatty acid supplementation. Fatty Acids, Omega-3 217-231 peroxisome proliferator activated receptor gamma Homo sapiens 155-166 12765846-8 2003 In conclusion, the Pro12Ala polymorphism of the PPAR-gamma2 gene may modify the inter-individual variability in serum triacylglycerol response to n-3 fatty acid supplementation. Fatty Acids, Omega-3 146-160 peroxisome proliferator activated receptor gamma Homo sapiens 48-59 12676476-8 2003 Interestingly, dietary omega-3 fatty acids can downregulate these processes and ameliorate DON-induced IgA nephropathy. Fatty Acids, Omega-3 23-42 CD79A antigen (immunoglobulin-associated alpha) Mus musculus 103-106 12480928-9 2003 Likewise, the omega-3 fatty acid eicosapentaenoic acid (EPA), which inhibits PKC beta II activity and colon carcinogenesis, causes inhibition of Cox-2 protein expression, re-expression of TGF-beta RII, and restoration of TGF-beta1-mediated transcription in RIE/PKC beta II cells. Fatty Acids, Omega-3 14-32 phospholipase C, beta 2 Rattus norvegicus 77-88 12480928-9 2003 Likewise, the omega-3 fatty acid eicosapentaenoic acid (EPA), which inhibits PKC beta II activity and colon carcinogenesis, causes inhibition of Cox-2 protein expression, re-expression of TGF-beta RII, and restoration of TGF-beta1-mediated transcription in RIE/PKC beta II cells. Fatty Acids, Omega-3 14-32 transforming growth factor, beta 1 Mus musculus 221-230 12480928-9 2003 Likewise, the omega-3 fatty acid eicosapentaenoic acid (EPA), which inhibits PKC beta II activity and colon carcinogenesis, causes inhibition of Cox-2 protein expression, re-expression of TGF-beta RII, and restoration of TGF-beta1-mediated transcription in RIE/PKC beta II cells. Fatty Acids, Omega-3 14-32 phospholipase C, beta 2 Rattus norvegicus 261-272 12480928-11 2003 Our data define a procarcinogenic PKC beta II --> Cox-2 --> TGF-beta signaling axis within the colonic epithelium, and provide a molecular mechanism by which dietary omega-3 fatty acids and nonsteroidal antiinflammatory agents such as Celecoxib suppress colon carcinogenesis. Fatty Acids, Omega-3 172-191 phospholipase C, beta 2 Rattus norvegicus 34-45 12480928-11 2003 Our data define a procarcinogenic PKC beta II --> Cox-2 --> TGF-beta signaling axis within the colonic epithelium, and provide a molecular mechanism by which dietary omega-3 fatty acids and nonsteroidal antiinflammatory agents such as Celecoxib suppress colon carcinogenesis. Fatty Acids, Omega-3 172-191 transforming growth factor, beta 1 Mus musculus 66-74 12847992-2 2003 Omega-3 fatty acids (n-3FAs) have desirable effects on serum triglyceride (TG) levels, thrombosis, and arrhythmia, but lead to increases in serum low-density lipoprotein (LDL) and apo-B as well. Fatty Acids, Omega-3 0-19 apolipoprotein B Homo sapiens 180-185 12757110-0 2003 Inhibition of activator protein-1 transcription factor activation by omega-3 fatty acid modulation of mitogen-activated protein kinase signaling kinases. Fatty Acids, Omega-3 69-87 jun proto-oncogene Mus musculus 14-33 12757110-5 2003 In this set of experiments, it was hypothesized that inhibition of MAPK signaling phosphorylation kinases by omega-3 fatty acids in a model of LPS-stimulated Mphi(s) would alter the activation of the proinflammatory cytokine transcription factor AP-1. Fatty Acids, Omega-3 109-128 mitogen-activated protein kinase 1 Mus musculus 67-71 12757110-5 2003 In this set of experiments, it was hypothesized that inhibition of MAPK signaling phosphorylation kinases by omega-3 fatty acids in a model of LPS-stimulated Mphi(s) would alter the activation of the proinflammatory cytokine transcription factor AP-1. Fatty Acids, Omega-3 109-128 jun proto-oncogene Mus musculus 246-250 12682744-9 2003 Omega-3 fatty acids are therefore considered to have an immunosuppressive effect on rat allogenic small intestinal transplantation based on the recipient plasma IL-1 beta, TNF and IL-2 levels and the histological findings of the grafts. Fatty Acids, Omega-3 0-19 interleukin 1 beta Rattus norvegicus 161-170 12682744-9 2003 Omega-3 fatty acids are therefore considered to have an immunosuppressive effect on rat allogenic small intestinal transplantation based on the recipient plasma IL-1 beta, TNF and IL-2 levels and the histological findings of the grafts. Fatty Acids, Omega-3 0-19 tumor necrosis factor Rattus norvegicus 172-175 12682744-9 2003 Omega-3 fatty acids are therefore considered to have an immunosuppressive effect on rat allogenic small intestinal transplantation based on the recipient plasma IL-1 beta, TNF and IL-2 levels and the histological findings of the grafts. Fatty Acids, Omega-3 0-19 interleukin 2 Rattus norvegicus 180-184 12654170-0 2003 The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study. Fatty Acids, Omega-3 22-37 C-reactive protein Homo sapiens 65-83 12706135-1 2003 BACKGROUND AND AIMS: Numerous studies suggest n -3 polyunsaturated fatty acids (n -3 PUFA) and oleic acid intake have beneficial effects on health including risk reduction of coronary heart disease. Fatty Acids, Omega-3 46-78 pumilio RNA binding family member 3 Homo sapiens 85-89 12388359-0 2003 NF-kappa B inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Fatty Acids, Omega-3 25-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 0-10 12562859-0 2003 Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. Fatty Acids, Omega-3 29-60 interleukin 1 beta Rattus norvegicus 109-127 12540386-0 2003 Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. Fatty Acids, Omega-3 45-59 apolipoprotein B Homo sapiens 97-117 12388359-0 2003 NF-kappa B inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Fatty Acids, Omega-3 25-45 tumor necrosis factor Mus musculus 82-91 12388359-1 2003 Omega-3 fatty acid (FA) emulsions reduce LPS-stimulated murine macrophage TNF-alpha production, but the exact mechanism has yet to be defined. Fatty Acids, Omega-3 0-18 tumor necrosis factor Mus musculus 74-83 12388359-8 2003 Moreover, omega-3-treated cells demonstrated significant decreases in both TNF-alpha mRNA and protein expression by 47 and 46%, respectively. Fatty Acids, Omega-3 10-17 tumor necrosis factor Mus musculus 75-84 12455601-0 2002 Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. Fatty Acids, Omega-3 17-32 albumin Gallus gallus 84-97 12421878-2 2002 Molecular mechanisms postulated to contribute to the multiple benefits of omega-3 fatty acids include 1) suppressing the expression of cyclooxygenase-2 in tumors, thus decreasing proliferation of cancer cells and reducing angiogenesis in the tumor; 2) decreasing the expression of AP-1 and ras, two oncogenes implicated in tumor promotion; 3) inducing differentiation of cancer cells; 4) suppressing nuclear factor-kappaB activation and bcl-2 expression, thus allowing apoptosis of cancer cells; and 5) reducing cancer-induced cachexia. Fatty Acids, Omega-3 74-93 prostaglandin-endoperoxide synthase 2 Homo sapiens 135-151 12421878-2 2002 Molecular mechanisms postulated to contribute to the multiple benefits of omega-3 fatty acids include 1) suppressing the expression of cyclooxygenase-2 in tumors, thus decreasing proliferation of cancer cells and reducing angiogenesis in the tumor; 2) decreasing the expression of AP-1 and ras, two oncogenes implicated in tumor promotion; 3) inducing differentiation of cancer cells; 4) suppressing nuclear factor-kappaB activation and bcl-2 expression, thus allowing apoptosis of cancer cells; and 5) reducing cancer-induced cachexia. Fatty Acids, Omega-3 74-93 BCL2 apoptosis regulator Homo sapiens 437-442 12468264-0 2002 The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. Fatty Acids, Omega-3 43-74 patchy fur Mus musculus 96-122 12468264-3 2002 We investigated the effect of dietary supplementation with n-3 fatty acids on endogenous PAF and LTB(4) biosynthesis in hypoxic-ischemic brain of young mice. Fatty Acids, Omega-3 59-74 patchy fur Mus musculus 89-92 12468264-11 2002 The present study shows that n-3 fatty-acid-enriched diet inhibits endogenous PAF and LTB(4) generation in hypoxic-ischemic brain tissue; however it demonstrates that 6 weeks of dietary supplementation with n-3 fatty acids results in a significant decrease in tissue level of PAF in the brain. Fatty Acids, Omega-3 29-43 patchy fur Mus musculus 78-81 12468264-11 2002 The present study shows that n-3 fatty-acid-enriched diet inhibits endogenous PAF and LTB(4) generation in hypoxic-ischemic brain tissue; however it demonstrates that 6 weeks of dietary supplementation with n-3 fatty acids results in a significant decrease in tissue level of PAF in the brain. Fatty Acids, Omega-3 29-43 patchy fur Mus musculus 276-279 12468264-11 2002 The present study shows that n-3 fatty-acid-enriched diet inhibits endogenous PAF and LTB(4) generation in hypoxic-ischemic brain tissue; however it demonstrates that 6 weeks of dietary supplementation with n-3 fatty acids results in a significant decrease in tissue level of PAF in the brain. Fatty Acids, Omega-3 207-222 patchy fur Mus musculus 78-81 12468264-11 2002 The present study shows that n-3 fatty-acid-enriched diet inhibits endogenous PAF and LTB(4) generation in hypoxic-ischemic brain tissue; however it demonstrates that 6 weeks of dietary supplementation with n-3 fatty acids results in a significant decrease in tissue level of PAF in the brain. Fatty Acids, Omega-3 207-222 patchy fur Mus musculus 276-279 12421842-0 2002 Antigen-driven murine CD4+ T lymphocyte proliferation and interleukin-2 production are diminished by dietary (n-3) polyunsaturated fatty acids. Fatty Acids, Omega-3 109-142 CD4 antigen Mus musculus 22-25 12421842-0 2002 Antigen-driven murine CD4+ T lymphocyte proliferation and interleukin-2 production are diminished by dietary (n-3) polyunsaturated fatty acids. Fatty Acids, Omega-3 109-142 interleukin 2 Mus musculus 58-71 12421842-1 2002 This study is the first to describe the impact of consuming a diet rich in (n-3) polyunsaturated fatty acids (PUFA) from fish oil on antigen-driven activation of naive CD4+ T lymphocytes. Fatty Acids, Omega-3 75-108 CD4 antigen Mus musculus 168-171 12421842-10 2002 In summary, we report for the first time that feeding mice a diet enriched with (n-3) PUFA reduces in vitro antigen-stimulated production of IL-2 and subsequent proliferation of naive CD4+ T lymphocytes. Fatty Acids, Omega-3 80-90 interleukin 2 Mus musculus 141-145 12421842-10 2002 In summary, we report for the first time that feeding mice a diet enriched with (n-3) PUFA reduces in vitro antigen-stimulated production of IL-2 and subsequent proliferation of naive CD4+ T lymphocytes. Fatty Acids, Omega-3 80-90 CD4 antigen Mus musculus 184-187 12401440-1 2002 We have previously reported that the n-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) inhibited the abnormal gap junctional intercellular communication (GJIC) induced by hypoxia/reoxygenation (H/R) via suppressing tyrosine kinase (TK) activation (Zhang et al., Prostaglandins Leukot Essent Fatty Acids, 1999; 61: 33-40). Fatty Acids, Omega-3 37-67 TXK tyrosine kinase Homo sapiens 224-239 12140281-1 2002 Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid that inhibits T lymphocyte activation, has been shown to stimulate phospholipase D (PLD) activity in stimulated human peripheral blood mononuclear cells (PBMC). Fatty Acids, Omega-3 31-61 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 146-149 12479567-2 2002 Subfamily proteins bind retinoids, subfamily II proteins bind bulky ligands, examples are intestinal bile acid binding protein (I-BABP) and liver fatty acid binding protein (L-FABP) which binds 2 ligand molecules, preferably monounsaturated and n-3 fatty acids. Fatty Acids, Omega-3 245-260 fatty acid binding protein 6 Homo sapiens 90-126 12479567-2 2002 Subfamily proteins bind retinoids, subfamily II proteins bind bulky ligands, examples are intestinal bile acid binding protein (I-BABP) and liver fatty acid binding protein (L-FABP) which binds 2 ligand molecules, preferably monounsaturated and n-3 fatty acids. Fatty Acids, Omega-3 245-260 fatty acid binding protein 6 Homo sapiens 128-134 12479567-2 2002 Subfamily proteins bind retinoids, subfamily II proteins bind bulky ligands, examples are intestinal bile acid binding protein (I-BABP) and liver fatty acid binding protein (L-FABP) which binds 2 ligand molecules, preferably monounsaturated and n-3 fatty acids. Fatty Acids, Omega-3 245-260 fatty acid binding protein 1 Homo sapiens 140-172 12479567-2 2002 Subfamily proteins bind retinoids, subfamily II proteins bind bulky ligands, examples are intestinal bile acid binding protein (I-BABP) and liver fatty acid binding protein (L-FABP) which binds 2 ligand molecules, preferably monounsaturated and n-3 fatty acids. Fatty Acids, Omega-3 245-260 fatty acid binding protein 1 Homo sapiens 174-180 12401440-1 2002 We have previously reported that the n-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) inhibited the abnormal gap junctional intercellular communication (GJIC) induced by hypoxia/reoxygenation (H/R) via suppressing tyrosine kinase (TK) activation (Zhang et al., Prostaglandins Leukot Essent Fatty Acids, 1999; 61: 33-40). Fatty Acids, Omega-3 37-67 TXK tyrosine kinase Homo sapiens 241-243 12384076-0 2002 Modulation of lipopolysaccharide-stimulated macrophage tumor necrosis factor-alpha production by omega-3 fatty acid is associated with differential cyclooxygenase-2 protein expression and is independent of interleukin-10. Fatty Acids, Omega-3 97-115 prostaglandin-endoperoxide synthase 2 Homo sapiens 148-164 12384076-7 2002 In addition, pretreatment with omega-3 FA dramatically decreased the PGE(2) and IL-10 production induced by LPS, whereas pretreatment with an equivalent dose of omega-6 FA only resulted in a modest increase in PGE(2) and a slight decrease in IL-10 production compared to controls. Fatty Acids, Omega-3 31-41 interleukin 10 Homo sapiens 80-85 12384076-7 2002 In addition, pretreatment with omega-3 FA dramatically decreased the PGE(2) and IL-10 production induced by LPS, whereas pretreatment with an equivalent dose of omega-6 FA only resulted in a modest increase in PGE(2) and a slight decrease in IL-10 production compared to controls. Fatty Acids, Omega-3 31-41 interleukin 10 Homo sapiens 242-247 12384076-11 2002 The decreased PGE(2) production could be attributed to the replacement of Mphi membrane omega-6 FA substrates by omega-3 FA and the competitive inhibition of COX-2 enzyme by omega-3 FA. Fatty Acids, Omega-3 174-184 prostaglandin-endoperoxide synthase 2 Homo sapiens 158-163 12384076-13 2002 Surprisingly, IL-10 production was decreased by omega-3 FA pretreatment, indicating that the reduced IL-10 inhibition of Mphi cytokine production was superceded by the other actions of omega-3 FA. Fatty Acids, Omega-3 48-58 interleukin 10 Homo sapiens 14-19 12384076-13 2002 Surprisingly, IL-10 production was decreased by omega-3 FA pretreatment, indicating that the reduced IL-10 inhibition of Mphi cytokine production was superceded by the other actions of omega-3 FA. Fatty Acids, Omega-3 48-58 interleukin 10 Homo sapiens 101-106 12115185-4 2002 RESULTS: Supplementation with n-3 PUFA (but not other fatty acids) reduced, in a dose-dependent manner, the endogenous and IL-1-induced release of proteoglycan metabolites from articular cartilage explants and specifically abolished endogenous aggrecanase and collagenase proteolytic activity. Fatty Acids, Omega-3 30-38 interleukin 1 alpha Homo sapiens 123-127 12163668-0 2002 Dietary (n-3) polyunsaturated fatty acids up-regulate plasma leptin in insulin-resistant rats. Fatty Acids, Omega-3 8-41 leptin Rattus norvegicus 61-67 12163668-1 2002 The study was designed to evaluate the chronic regulation of plasma leptin by dietary (n-3) polyunsaturated fatty acids (PUFA) in insulin-resistant, sucrose-fed rats. Fatty Acids, Omega-3 87-119 leptin Rattus norvegicus 68-74 12081840-10 2002 CONCLUSION: The inclusion of n-3 PUFAs in a meal alters the gastric emptying rate, potentially as the result of changes in the pattern of cholecystokinin and glucagon-like peptide 1 release. Fatty Acids, Omega-3 29-38 glucagon Homo sapiens 158-181 12519481-0 2002 Omega-3 fatty acid lipid emulsion reduces LPS-stimulated macrophage TNF-alpha production. Fatty Acids, Omega-3 0-18 tumor necrosis factor Mus musculus 68-77 12519481-4 2002 In the present work, this omega-3 FA emulsion has been evaluated in order to define its effects on TNF-alpha production in a model of LPS-stimulated macrophages. Fatty Acids, Omega-3 26-36 tumor necrosis factor Mus musculus 99-108 12519481-10 2002 CONCLUSION: Four-hour omega-3 FA emulsion pretreatment significantly attenuated LPS-stimulated macrophage TNF-alpha production. Fatty Acids, Omega-3 22-32 tumor necrosis factor Mus musculus 106-115 12519481-11 2002 These data support the contention that antiinflammatory effects of omega-3 FA occur at least in part through the inhibition of macrophage TNF-alpha production in response to endotoxin. Fatty Acids, Omega-3 67-77 tumor necrosis factor Mus musculus 138-147 12058013-6 2002 These data indicate that dietary omega-3 fatty acids prevent colon cancer, at least in part, through inhibition of colonic PKCbetaII signaling and restoration of TGF-beta responsiveness. Fatty Acids, Omega-3 33-52 transforming growth factor, beta 1 Mus musculus 162-170 12149216-0 2002 Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha. Fatty Acids, Omega-3 9-28 peroxisome proliferator activated receptor alpha Mus musculus 106-116 12149216-7 2002 Therefore, the beneficial effects of omega-3 fatty acids may be explained by a PPAR alpha-mediated anti-inflammatory effect of oxidized EPA. Fatty Acids, Omega-3 37-56 peroxisome proliferator activated receptor alpha Mus musculus 79-89 12165360-12 2002 The data obtained from this study in MRL/lpr and MRL/++ mice suggest that FO diets containing omega-3 fatty acids are beneficial in decreasing the levels of certain pro-inflammatory chemokines (RANTES and MCP-1) thereby delaying the onset of and severity of autoimmune symptoms in MRL/lpr mouse model. Fatty Acids, Omega-3 94-113 Fas (TNF receptor superfamily member 6) Mus musculus 41-44 12165360-12 2002 The data obtained from this study in MRL/lpr and MRL/++ mice suggest that FO diets containing omega-3 fatty acids are beneficial in decreasing the levels of certain pro-inflammatory chemokines (RANTES and MCP-1) thereby delaying the onset of and severity of autoimmune symptoms in MRL/lpr mouse model. Fatty Acids, Omega-3 94-113 chemokine (C-C motif) ligand 5 Mus musculus 194-200 12165360-12 2002 The data obtained from this study in MRL/lpr and MRL/++ mice suggest that FO diets containing omega-3 fatty acids are beneficial in decreasing the levels of certain pro-inflammatory chemokines (RANTES and MCP-1) thereby delaying the onset of and severity of autoimmune symptoms in MRL/lpr mouse model. Fatty Acids, Omega-3 94-113 chemokine (C-C motif) ligand 2 Mus musculus 205-210 12165360-12 2002 The data obtained from this study in MRL/lpr and MRL/++ mice suggest that FO diets containing omega-3 fatty acids are beneficial in decreasing the levels of certain pro-inflammatory chemokines (RANTES and MCP-1) thereby delaying the onset of and severity of autoimmune symptoms in MRL/lpr mouse model. Fatty Acids, Omega-3 94-113 Fas (TNF receptor superfamily member 6) Mus musculus 285-288 12064337-5 2002 Real-time quantitative polymerase chain reaction determinations conclusively demonstrated increases in BRCA1 and BRCA2 mRNA expressions in MCF7 and MDA-MB 231 tumour cell lines after treatment with n-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid), but no variation was noticed with the n-6 polyunsaturated fatty acid (arachidonic acid). Fatty Acids, Omega-3 198-229 BRCA1 DNA repair associated Homo sapiens 103-108 12068080-7 2002 In n-3 fatty acid deficient rats, GLUT1-immunoreactivity readily detectable in microvessels became sparse, whereas the number of GLUT3 immunoreactive neurones was increased. Fatty Acids, Omega-3 3-17 solute carrier family 2 member 1 Rattus norvegicus 34-39 12068080-7 2002 In n-3 fatty acid deficient rats, GLUT1-immunoreactivity readily detectable in microvessels became sparse, whereas the number of GLUT3 immunoreactive neurones was increased. Fatty Acids, Omega-3 3-17 solute carrier family 2 member 3 Rattus norvegicus 129-134 11971949-0 2002 Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice. Fatty Acids, Omega-3 41-56 low density lipoprotein receptor Mus musculus 60-72 12084030-1 2002 BACKGROUND: : Previously, we have observed that highly unsaturated dietary (n-3) fatty acids inhibit cell proliferation in conjunction with stimulation of insulin-like growth factor-binding protein (IGFBP)-6 secretion in Caco-2 cells, a human colon carcinoma cell line. Fatty Acids, Omega-3 75-92 insulin like growth factor binding protein 6 Homo sapiens 155-207 12064337-5 2002 Real-time quantitative polymerase chain reaction determinations conclusively demonstrated increases in BRCA1 and BRCA2 mRNA expressions in MCF7 and MDA-MB 231 tumour cell lines after treatment with n-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid), but no variation was noticed with the n-6 polyunsaturated fatty acid (arachidonic acid). Fatty Acids, Omega-3 198-229 BRCA2 DNA repair associated Homo sapiens 113-118 12064337-8 2002 We suggest the presence of a possible transcriptional or post-transcriptional regulation of BRCA1 and BRCA2 after n-3 polyunsaturated fatty acid treatment in breast tumour cells. Fatty Acids, Omega-3 114-144 BRCA1 DNA repair associated Homo sapiens 92-97 12064337-8 2002 We suggest the presence of a possible transcriptional or post-transcriptional regulation of BRCA1 and BRCA2 after n-3 polyunsaturated fatty acid treatment in breast tumour cells. Fatty Acids, Omega-3 114-144 BRCA2 DNA repair associated Homo sapiens 102-107 11832371-0 2002 N-3 polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle. Fatty Acids, Omega-3 0-31 insulin receptor Rattus norvegicus 54-70 12062374-1 2002 OBJECTIVE: Omega-3 polyunsaturated fatty acids (omega-3 PUFA) from fish oil slow atherosclerosis progression in coronary arteries, as we showed in a randomized double-blind placebo-controlled clinical trial. Fatty Acids, Omega-3 11-46 pumilio RNA binding family member 3 Homo sapiens 56-60 11918718-0 2002 Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha, IL-6 and PGE2 expression in UVB-irradiated human keratinocytes. Fatty Acids, Omega-3 25-55 tumor necrosis factor Homo sapiens 81-90 11918718-0 2002 Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha, IL-6 and PGE2 expression in UVB-irradiated human keratinocytes. Fatty Acids, Omega-3 25-55 interleukin 1 alpha Homo sapiens 92-101 11918718-0 2002 Eicosapentaenoic acid, a n-3 polyunsaturated fatty acid differentially modulates TNF-alpha, IL-1alpha, IL-6 and PGE2 expression in UVB-irradiated human keratinocytes. Fatty Acids, Omega-3 25-55 interleukin 6 Homo sapiens 103-107 11872265-1 2002 We hypothesized that the chronic dietary deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) might affect the density and/or function of dopamine transporters (DAT), which have a major role in regulating the synaptic level of dopamine. Fatty Acids, Omega-3 55-86 solute carrier family 6 member 3 Rattus norvegicus 143-164 11872265-1 2002 We hypothesized that the chronic dietary deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) might affect the density and/or function of dopamine transporters (DAT), which have a major role in regulating the synaptic level of dopamine. Fatty Acids, Omega-3 55-86 solute carrier family 6 member 3 Rattus norvegicus 166-169 11872265-1 2002 We hypothesized that the chronic dietary deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) might affect the density and/or function of dopamine transporters (DAT), which have a major role in regulating the synaptic level of dopamine. Fatty Acids, Omega-3 88-97 solute carrier family 6 member 3 Rattus norvegicus 143-164 11872265-1 2002 We hypothesized that the chronic dietary deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) might affect the density and/or function of dopamine transporters (DAT), which have a major role in regulating the synaptic level of dopamine. Fatty Acids, Omega-3 88-97 solute carrier family 6 member 3 Rattus norvegicus 166-169 11832371-8 2002 In conclusion, a high-fat diet enriched in n-3 fatty acids maintained IR, IRS-1 tyrosine phosphorylation, and PI 3"-kinase activity and total GLUT-44 content in muscle but not in liver. Fatty Acids, Omega-3 43-58 insulin receptor Rattus norvegicus 70-72 11832371-8 2002 In conclusion, a high-fat diet enriched in n-3 fatty acids maintained IR, IRS-1 tyrosine phosphorylation, and PI 3"-kinase activity and total GLUT-44 content in muscle but not in liver. Fatty Acids, Omega-3 43-58 insulin receptor substrate 1 Rattus norvegicus 74-79 12014621-4 2002 MATERIALS AND METHODS: Adenoviral strategies were used to introduce the C. elegans fat-1 gene encoding an n-3 fatty acid desaturase into human breast cancer cells followed by examination of the n-6/n-3 fatty acid ratio and growth of the cells. Fatty Acids, Omega-3 106-120 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 83-88 12031825-2 2002 Fish consumption has been inversely related to coronary disease, which has been partly attributed to an inhibitory effect of n-3 polyunsaturated fatty acids (n-3 PUFA) on platelet production of tromboxane A2. Fatty Acids, Omega-3 125-156 pumilio RNA binding family member 3 Homo sapiens 162-166 12064327-5 2002 Increased apoptosis in human BC cells following exposure to long-chain n-3 FA such as eicosapentaenoic and docosahexaenoic acids is generally ascribed to their inhibition of cyclooxygenase 2 which promotes mammary carcinogenesis. Fatty Acids, Omega-3 71-77 prostaglandin-endoperoxide synthase 2 Homo sapiens 174-190 12018979-2 2002 omega-3 fatty acids decrease the production of putative mediators of inflammation, including interleukin-1, and tumor necrosis factor. Fatty Acids, Omega-3 0-19 tumor necrosis factor Homo sapiens 112-133 12018979-3 2002 Since interleukin-1 and tumor necrosis factor are the principal polypeptide mediators of immunoregulation, reduced production of these cytokines by dietary supplementation with omega-3, may be a possible mechanism for the treatment of chronic fatigue syndrome. Fatty Acids, Omega-3 177-184 interleukin 1 alpha Homo sapiens 6-45 11544435-3 2001 In this study, we examined plasma levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL) 10, and their relations to antioxidant vitamins in 45 HTx recipients before and after treatment with omega-3 fatty acids or placebo. Fatty Acids, Omega-3 203-222 tumor necrosis factor Homo sapiens 44-71 11829698-11 2002 CONCLUSIONS: A modified Mediterranean-type diet rich in omega-3 fatty acids efficiently potentiated the cholesterol-lowering effect of simvastatin, counteracted the fasting insulin-elevating effect of simvastatin, and, unlike simvastatin, did not decrease serum levels of beta-carotene and ubiquinol-10. Fatty Acids, Omega-3 56-75 insulin Homo sapiens 173-180 12653178-12 2002 We have also found that n-3 fatty acids plus CoQ can decrease TNF-alpha and IL-6 in AMI which are pro-inflammatory agents. Fatty Acids, Omega-3 24-39 tumor necrosis factor Homo sapiens 62-71 12653178-12 2002 We have also found that n-3 fatty acids plus CoQ can decrease TNF-alpha and IL-6 in AMI which are pro-inflammatory agents. Fatty Acids, Omega-3 24-39 interleukin 6 Homo sapiens 76-80 11781670-20 2001 Supplement-enriched formula, with peptides and n-3 fatty acids, increased CD4 count. Fatty Acids, Omega-3 47-62 CD4 molecule Homo sapiens 74-77 11789299-2 2001 Our objective was to examine whether a dietary supplement containing omega-3 fatty acids (n-3 FA) can reduce the levels of serum lipids, fasting insulin and glucose in documented CVD patients treated by statins or bezafibrates. Fatty Acids, Omega-3 69-88 insulin Homo sapiens 145-152 11684525-9 2001 Oleic and n-3 fatty acids from adipose regions were negatively correlated with apolipoprotein B and triacylglycerols; adipose tissue 22:1n-9, 20:2n-6, stearic acid, and eicosapentaenoic acid were positively correlated with HDL and apolipoprotein A; and adipose tissue myristic acid was negatively correlated with apolipoprotein A (P < 0.05). Fatty Acids, Omega-3 10-25 apolipoprotein B Homo sapiens 79-95 11684525-9 2001 Oleic and n-3 fatty acids from adipose regions were negatively correlated with apolipoprotein B and triacylglycerols; adipose tissue 22:1n-9, 20:2n-6, stearic acid, and eicosapentaenoic acid were positively correlated with HDL and apolipoprotein A; and adipose tissue myristic acid was negatively correlated with apolipoprotein A (P < 0.05). Fatty Acids, Omega-3 10-25 lipoprotein(a) Homo sapiens 231-247 11684525-9 2001 Oleic and n-3 fatty acids from adipose regions were negatively correlated with apolipoprotein B and triacylglycerols; adipose tissue 22:1n-9, 20:2n-6, stearic acid, and eicosapentaenoic acid were positively correlated with HDL and apolipoprotein A; and adipose tissue myristic acid was negatively correlated with apolipoprotein A (P < 0.05). Fatty Acids, Omega-3 10-25 lipoprotein(a) Homo sapiens 313-329 11885896-12 2002 The content of n-3 fatty acids in SP2, SP4, and SP5 were similar to control eggs. Fatty Acids, Omega-3 15-30 Sp2 transcription factor Gallus gallus 34-37 11885896-12 2002 The content of n-3 fatty acids in SP2, SP4, and SP5 were similar to control eggs. Fatty Acids, Omega-3 15-30 Sp4 transcription factor Gallus gallus 39-42 11885896-12 2002 The content of n-3 fatty acids in SP2, SP4, and SP5 were similar to control eggs. Fatty Acids, Omega-3 15-30 Sp5 transcription factor Gallus gallus 48-51 11531960-5 2001 The IL-4 driven proliferation of putative Th2 CD4 cells was enhanced by dietary n-3 fatty acids (P = 0.02). Fatty Acids, Omega-3 80-95 interleukin 4 Mus musculus 4-8 11531960-5 2001 The IL-4 driven proliferation of putative Th2 CD4 cells was enhanced by dietary n-3 fatty acids (P = 0.02). Fatty Acids, Omega-3 80-95 CD4 antigen Mus musculus 46-49 11531960-9 2001 These data suggest that dietary n-3 fatty acids down-regulated IL-2 driven CD4 and CD8 activation, while up-regulating the activation of the Th2 CD4 T-cell subset. Fatty Acids, Omega-3 32-47 interleukin 2 Mus musculus 63-67 11531960-9 2001 These data suggest that dietary n-3 fatty acids down-regulated IL-2 driven CD4 and CD8 activation, while up-regulating the activation of the Th2 CD4 T-cell subset. Fatty Acids, Omega-3 32-47 CD4 antigen Mus musculus 75-78 11531960-9 2001 These data suggest that dietary n-3 fatty acids down-regulated IL-2 driven CD4 and CD8 activation, while up-regulating the activation of the Th2 CD4 T-cell subset. Fatty Acids, Omega-3 32-47 CD4 antigen Mus musculus 145-148 11531960-10 2001 Thus, the anti-inflammatory effects of n-3 fatty acids may result in both the direct suppression of IL-2-induced Th1 cell activation and the indirect suppression of Th1 cells by the enhanced cross-regulatory function of Th2 cells. Fatty Acids, Omega-3 39-54 interleukin 2 Mus musculus 100-104 11544435-8 2001 During omega-3 fatty-acid treatment, but not during placebo, there was a decrease in vitamin E (P<0.05) and beta-carotene (P<0.05) levels, and the decrease in vitamin E was inversely correlated with the increase in TNF-alpha (r= -0.56, P<0.01). Fatty Acids, Omega-3 7-25 tumor necrosis factor Homo sapiens 221-230 11544435-9 2001 The rise in TNF-alpha levels during omega-3 fatty acids treatment was most pronounced in those patients with transplant coronary artery disease (P<0.04). Fatty Acids, Omega-3 36-55 tumor necrosis factor Homo sapiens 12-21 11470750-2 2001 We wanted to explore whether omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can affect androgen receptor function in prostate cancer cells. Fatty Acids, Omega-3 29-64 androgen receptor Homo sapiens 143-160 11470750-10 2001 Thus, this study found that the inhibitory effects of omega-3 polyunsaturated fatty acids on AR-mediated actions are due, at least in part, to an increase in c-jun protein. Fatty Acids, Omega-3 54-89 androgen receptor Homo sapiens 93-95 11470750-10 2001 Thus, this study found that the inhibitory effects of omega-3 polyunsaturated fatty acids on AR-mediated actions are due, at least in part, to an increase in c-jun protein. Fatty Acids, Omega-3 54-89 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 158-163 11466662-4 2001 The largest long-term clinical trial evaluating n-3 fatty acids in high-risk patients with IgAN showed that early and prolonged treatment with n-3 fatty acids retards renal progression. Fatty Acids, Omega-3 48-63 IGAN1 Homo sapiens 91-95 11590875-1 2001 In order to evaluate the effect of marine n-3 polyunsaturated fatty acids (n-3 PUFA) on systolic left ventricular function, we investigated the effect of daily supplementation with 5.2 g n-3 PUFA for 12 weeks in 55 patients with a recent myocardial infarction in a double blind placebo-controlled design. Fatty Acids, Omega-3 42-73 pumilio RNA binding family member 3 Homo sapiens 79-83 11681814-5 2001 n-3 Polyunsaturated fatty acids (n-3 PUFA), glutamine, arginine, S amino acids and nucleotides are important components of immunonutrient mixes. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 37-41 11285257-2 2001 We previously showed that Omega-3 fatty acids reduce secretion of apolipoprotein B (apoB) from cultured hepatocytes by stimulating post-translational degradation. Fatty Acids, Omega-3 26-45 apolipoprotein B Homo sapiens 66-82 11285257-2 2001 We previously showed that Omega-3 fatty acids reduce secretion of apolipoprotein B (apoB) from cultured hepatocytes by stimulating post-translational degradation. Fatty Acids, Omega-3 26-45 apolipoprotein B Homo sapiens 84-88 11285257-4 2001 First, we found that Omega-3-induced degradation preferentially reduces the secretion of large, assembled apoB-lipoprotein particles, and apoB polypeptide length is not a determinant. Fatty Acids, Omega-3 21-28 apolipoprotein B Homo sapiens 106-110 11285257-6 2001 Third, re-uptake, the only process known to destroy fully assembled nascent lipoproteins, was clearly active in primary hepatocytes, but Omega-3-induced degradation of apoB continued even when re-uptake was blocked. Fatty Acids, Omega-3 137-144 apolipoprotein B Homo sapiens 168-172 11285257-7 2001 Cell fractionation showed that Omega-3 fatty acids induced a striking loss of apoB100 from the Golgi, while sparing apoB100 in the ER, indicating a post-ER process. Fatty Acids, Omega-3 31-50 apolipoprotein B Homo sapiens 78-85 11285257-7 2001 Cell fractionation showed that Omega-3 fatty acids induced a striking loss of apoB100 from the Golgi, while sparing apoB100 in the ER, indicating a post-ER process. Fatty Acids, Omega-3 31-50 apolipoprotein B Homo sapiens 116-123 11427212-0 2001 Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus. Fatty Acids, Omega-3 18-37 apolipoprotein A1 Homo sapiens 66-83 11466662-4 2001 The largest long-term clinical trial evaluating n-3 fatty acids in high-risk patients with IgAN showed that early and prolonged treatment with n-3 fatty acids retards renal progression. Fatty Acids, Omega-3 143-158 IGAN1 Homo sapiens 91-95 11471489-0 2001 Effect of omega-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line. Fatty Acids, Omega-3 10-28 BRCA1 DNA repair associated Homo sapiens 54-59 11360128-2 2001 Plasma leptin concentrations and gene expression have been related to n-3 fatty acids. Fatty Acids, Omega-3 70-85 leptin Homo sapiens 7-13 11171151-1 2000 In order to define the substrate requirements, regiochemistry and cryptoregiochemistry of the omega-3 fatty acid desaturases involved in polyunsaturated fatty acid formation, the genes Fad3 and fat-1 from Brassica napus and the nematode Caenorhabditis elegans respectively were expressed in baker"s yeast (Saccharomyces cerevisiae). Fatty Acids, Omega-3 94-112 omega-3 fatty acid desaturase, endoplasmic reticulum Brassica napus 185-189 11838000-3 2001 In two independent studies, we demonstrated that mRNA levels for PDGF-A and -B and for MCP-1 are reduced after ingestion of n-3 fatty acids by human volunteers. Fatty Acids, Omega-3 124-139 platelet derived growth factor subunit A Homo sapiens 65-78 11838000-3 2001 In two independent studies, we demonstrated that mRNA levels for PDGF-A and -B and for MCP-1 are reduced after ingestion of n-3 fatty acids by human volunteers. Fatty Acids, Omega-3 124-139 C-C motif chemokine ligand 2 Homo sapiens 87-92 11080210-4 2000 Levels of total brain n-3 fatty acids were reduced in the n-3 Def group by 83 and 87% in the F2 and F3 generations, respectively. Fatty Acids, Omega-3 22-37 UTP25 small subunit processome component Rattus norvegicus 62-65 11202508-1 2000 The chronic oral administration of epaden (a concentrate of n-3 polyunsaturated fatty acids, n-3 PUFA) to rabbits leads to a decrease in activity of the tissue type plasminogen activator (t-PA) in the blood plasma. Fatty Acids, Omega-3 60-91 tissue-type plasminogen activator Oryctolagus cuniculus 153-186 11192938-0 2000 Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. Fatty Acids, Omega-3 60-75 prostaglandin-endoperoxide synthase 2 Homo sapiens 80-96 11192938-0 2000 Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. Fatty Acids, Omega-3 60-75 pumilio RNA binding family member 3 Homo sapiens 163-167 11103817-0 2000 Induction of mammary differentiation by mammary-derived growth inhibitor-related gene that interacts with an omega-3 fatty acid on growth inhibition of breast cancer cells. Fatty Acids, Omega-3 109-127 fatty acid binding protein 7 Homo sapiens 40-85 11202508-1 2000 The chronic oral administration of epaden (a concentrate of n-3 polyunsaturated fatty acids, n-3 PUFA) to rabbits leads to a decrease in activity of the tissue type plasminogen activator (t-PA) in the blood plasma. Fatty Acids, Omega-3 93-101 tissue-type plasminogen activator Oryctolagus cuniculus 153-186 11029968-0 2000 Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat. Fatty Acids, Omega-3 8-23 uncoupling protein 1 Rattus norvegicus 66-86 11104282-1 2000 Lactating cows were fed menhaden fish oil to elevate concentrations of conjugated linoleic acid, transvaccenic acid, and n-3 fatty acids in milk. Fatty Acids, Omega-3 121-136 Weaning weight-maternal milk Bos taurus 140-144 11104282-11 2000 The n-3 fatty acids increased from a trace to over 1 g/100 g of milk fatty acids, when the 3% fish oil diet was fed. Fatty Acids, Omega-3 4-19 Weaning weight-maternal milk Bos taurus 64-68 11104282-12 2000 Fish oil supplementation to diets of dairy cows increased the conjugated linoleic acid, transvaccenic acid, and n-3 fatty acids in milk. Fatty Acids, Omega-3 112-127 Weaning weight-maternal milk Bos taurus 131-135 11034610-0 2000 Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. Fatty Acids, Omega-3 94-113 prostaglandin-endoperoxide synthase 2 Homo sapiens 118-134 11034610-3 2000 Human endothelial cells with upregulated COX-2 treated with ASA converted C20:5 omega-3 to 18R-hydroxyeicosapentaenoic acid (HEPE) and 15R-HEPE. Fatty Acids, Omega-3 80-87 prostaglandin-endoperoxide synthase 2 Homo sapiens 41-46 10946095-2 2000 A fish oil-supplemented diet containing n-3 polyunsaturated fatty acids (PUFA) reduces thromboxane A(2) (TxA(2)) synthesis and, thus, vasoconstriction and platelet aggregation. Fatty Acids, Omega-3 40-71 Polyunsaturated fatty acid percentage Sus scrofa 73-77 10901195-1 2000 Dietary intake of omega-3 fatty acids (n-3 PUFA) decreases the risk of heart disease, inhibits the growth of prostate and breast cancer, delays the loss of immunological functions, and is required for normal fetal brain and visual development. Fatty Acids, Omega-3 18-37 pumilio RNA binding family member 3 Homo sapiens 43-47 10715540-0 2000 Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells. Fatty Acids, Omega-3 95-102 peroxisome proliferator activated receptor gamma Homo sapiens 43-91 10793236-2 2000 Here, we examined a possible correlation between nerve growth factor (NGF) content and n-3 fatty acid status in the brain. Fatty Acids, Omega-3 87-101 nerve growth factor Rattus norvegicus 49-68 10793236-2 2000 Here, we examined a possible correlation between nerve growth factor (NGF) content and n-3 fatty acid status in the brain. Fatty Acids, Omega-3 87-101 nerve growth factor Rattus norvegicus 70-73 10713313-3 2000 Dietary intervention with very long n-3 fatty acids from marine sources is known to decrease serum triglycerides, but an adverse increase in PAI-1 activity has been reported in some studies. Fatty Acids, Omega-3 36-51 serpin family E member 1 Homo sapiens 141-146 10713313-12 2000 In a review of 17 trials, including 935 subjects that assessed the effect of n-3 fatty acids on PAI-1 activity, an overall 17.7% increase in PAI-1 activity was estimated by n-3 supplementation. Fatty Acids, Omega-3 77-92 serpin family E member 1 Homo sapiens 96-101 10713313-12 2000 In a review of 17 trials, including 935 subjects that assessed the effect of n-3 fatty acids on PAI-1 activity, an overall 17.7% increase in PAI-1 activity was estimated by n-3 supplementation. Fatty Acids, Omega-3 77-92 serpin family E member 1 Homo sapiens 141-146 10713313-13 2000 However, only two studies were able to demonstrate a significant increase in PAI-1 attributable to n-3 fatty acid supplementation. Fatty Acids, Omega-3 99-113 serpin family E member 1 Homo sapiens 77-82 10715540-3 2000 Whereas omega-3 fatty acids inhibit transactivation of PPARgamma to levels below control, omega-6, monounsaturated and saturated fatty acids stimulate the activity of the transcriptional reporter. Fatty Acids, Omega-3 8-27 peroxisome proliferator activated receptor gamma Homo sapiens 55-64 10720161-4 2000 A diet high in (n-3) polyunsaturated fatty acids was predicted to be associated with higher levels of lipoprotein lipase (LPL) activity and expression and lower levels of plasma triglyceride after a high fat meal challenge. Fatty Acids, Omega-3 15-48 lipoprotein lipase Rattus norvegicus 102-120 10720161-4 2000 A diet high in (n-3) polyunsaturated fatty acids was predicted to be associated with higher levels of lipoprotein lipase (LPL) activity and expression and lower levels of plasma triglyceride after a high fat meal challenge. Fatty Acids, Omega-3 15-48 lipoprotein lipase Rattus norvegicus 122-125 10617967-1 2000 In the past 2 decades, views about dietary n-3 fatty acids have moved from speculation about their functions to solid evidence that they are not only essential nutrients but also may favorably modulate many diseases. Fatty Acids, Omega-3 43-58 EH domain containing 2 Homo sapiens 7-13 10696629-7 2000 Treatment with omega-3 fatty acids resulted in greater disease activity as detected by a significant increase in platelet count, erythrocyte sedimentation rate, C-reactive protein, and total fecal nitrogen excretion. Fatty Acids, Omega-3 15-34 C-reactive protein Homo sapiens 161-179 10617995-4 2000 These doses of n-3 fatty acids are associated with significant reductions in the release of leukotriene B(4) from stimulated neutrophils and of interleukin 1 from monocytes. Fatty Acids, Omega-3 15-30 interleukin 1 alpha Homo sapiens 144-157 10539783-4 1999 The objectives of this study were to increase the concentrations of beneficial fatty acids in milk fat by feeding a diet rich in (n-3) fatty acids from algae to dairy cows. Fatty Acids, Omega-3 129-146 Weaning weight-maternal milk Bos taurus 94-98 10763110-1 2000 Epaden, the new domestic concentrate of n-3 polyunsaturated fatty acids (PUFA), is capable of inhibiting in vitro the human thrombocyte aggregation induced by ADP, collagen, and thrombin. Fatty Acids, Omega-3 40-71 coagulation factor II, thrombin Homo sapiens 178-186 10642312-0 2000 Endothelin-1 attenuates omega3 fatty acid-induced apoptosis by inhibition of caspase 3. Fatty Acids, Omega-3 24-41 endothelin 1 Homo sapiens 0-12 10642312-0 2000 Endothelin-1 attenuates omega3 fatty acid-induced apoptosis by inhibition of caspase 3. Fatty Acids, Omega-3 24-41 caspase 3 Homo sapiens 77-86 10890025-4 2000 Our data show a consistent tendency for a lower risk of SCC with higher intakes of n-3 fatty acids [p (for trend) = 0.055]. Fatty Acids, Omega-3 83-98 serpin family B member 3 Homo sapiens 56-59 10965515-5 2000 The evidence suggests that diets high in energy and saturated fat and with high glycemic index carbohydrate and low levels of fiber and n-3 fatty acids lead to insulin resistance with hyperinsulinemia, hyperglycemia, and hypertriglyceridemia. Fatty Acids, Omega-3 52-65 insulin Homo sapiens 160-167 10965515-5 2000 The evidence suggests that diets high in energy and saturated fat and with high glycemic index carbohydrate and low levels of fiber and n-3 fatty acids lead to insulin resistance with hyperinsulinemia, hyperglycemia, and hypertriglyceridemia. Fatty Acids, Omega-3 136-151 insulin Homo sapiens 160-167 10632966-0 2000 Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Fatty Acids, Omega-3 0-19 interleukin 6 Homo sapiens 98-111 10600352-2 1999 We have previously reported that polyunsaturated n-3 fatty acids (n-3 FA) including eicosapentaenoic acid (20:5) and docosahexaenoic acid (22:6) prevent the activation of monocytic tissue factor (TF) induced by bacterial endotoxin [lipopolysaccharide (LPS)] in cell cultures and animals. Fatty Acids, Omega-3 66-72 coagulation factor III, tissue factor Homo sapiens 181-194 10600352-2 1999 We have previously reported that polyunsaturated n-3 fatty acids (n-3 FA) including eicosapentaenoic acid (20:5) and docosahexaenoic acid (22:6) prevent the activation of monocytic tissue factor (TF) induced by bacterial endotoxin [lipopolysaccharide (LPS)] in cell cultures and animals. Fatty Acids, Omega-3 66-72 coagulation factor III, tissue factor Homo sapiens 196-198 10600352-5 1999 Pretreatment with n-3 FA, 20:5 and 22:6 at 10 microM, resulted in time-dependent suppression of not only TF activation but also the elicitation of NO, TNF-alpha, and IL-1beta. Fatty Acids, Omega-3 18-24 coagulation factor III, tissue factor Homo sapiens 105-107 10600352-5 1999 Pretreatment with n-3 FA, 20:5 and 22:6 at 10 microM, resulted in time-dependent suppression of not only TF activation but also the elicitation of NO, TNF-alpha, and IL-1beta. Fatty Acids, Omega-3 18-24 tumor necrosis factor Homo sapiens 151-160 10600352-5 1999 Pretreatment with n-3 FA, 20:5 and 22:6 at 10 microM, resulted in time-dependent suppression of not only TF activation but also the elicitation of NO, TNF-alpha, and IL-1beta. Fatty Acids, Omega-3 18-24 interleukin 1 beta Homo sapiens 166-174 10574656-1 1999 The present study was designed to investigate the effect of dietary n-6 and n-3 polyunsaturated fatty acids (PUFA) on anti-CD3 and anti-Fas antibody-induced apoptosis and its mediators in mouse spleen cells. Fatty Acids, Omega-3 76-107 CD3 antigen, epsilon polypeptide Mus musculus 123-126 10485437-11 1999 Thus, our data suggest that the incorporation of omega-3 TG with LCT/MCT will result in greater delivery of omega-3 fatty acids to extrahepatic tissue, which could be important in modulating immune and other responses. Fatty Acids, Omega-3 108-127 lactase Mus musculus 65-68 10485437-11 1999 Thus, our data suggest that the incorporation of omega-3 TG with LCT/MCT will result in greater delivery of omega-3 fatty acids to extrahepatic tissue, which could be important in modulating immune and other responses. Fatty Acids, Omega-3 108-127 microcephaly, primary autosomal recessive 1 Mus musculus 69-72 10582655-4 1999 On the other hand, BCL-2 prevented apoptosis induced by these long-chain fatty acids, where as n-3 fatty acids suppressed ras expression leading to suppression of development of overt neoplasia. Fatty Acids, Omega-3 95-110 BCL2 apoptosis regulator Homo sapiens 19-24 10433502-0 1999 Blockade by N-3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese hamster ovary cells. Fatty Acids, Omega-3 12-42 potassium voltage-gated channel subfamily D member 3 Homo sapiens 50-55 10529090-11 1999 Results are discussed in terms of the influence that arachidonic and n-3 polyunsaturated fatty acids may exert on the transcriptional and translational control of the GLUT4 gene. Fatty Acids, Omega-3 69-100 solute carrier family 2 member 4 Rattus norvegicus 167-172 10433502-5 1999 Epidemiological, clinical, animal, and cellular studies indicate that these arrhythmias may be ameliorated in myocardial ischaemia by n-3 polyunsaturated fatty acids (n-3 PUFA) present in fish oils. Fatty Acids, Omega-3 134-165 pumilio RNA binding family member 3 Homo sapiens 171-175 10024686-4 1999 In this study we have demonstrated the presence of two immunoreactive isoforms of cyclooxygenase (COX-1 and -2), and the modulating effects of n-3 fatty acids on their expression, in N-nitrosomethylurea (NMU)-induced rat mammary tumors. Fatty Acids, Omega-3 143-158 cytochrome c oxidase I, mitochondrial Rattus norvegicus 98-110 10024686-7 1999 Moreover, the high menhaden oil diet (rich in n-3 fatty acids) significantly suppressed both COX-1 (-28%) and COX-2 (-36%) protein levels when compared to the high corn oil diet. Fatty Acids, Omega-3 46-61 cytokinin dehydrogenase 1 Zea mays 93-98 10024686-7 1999 Moreover, the high menhaden oil diet (rich in n-3 fatty acids) significantly suppressed both COX-1 (-28%) and COX-2 (-36%) protein levels when compared to the high corn oil diet. Fatty Acids, Omega-3 46-61 cytochrome c oxidase II, mitochondrial Rattus norvegicus 110-115 10024686-9 1999 The mechanism(s) by which n-3 fatty acids suppress COX-1 and COX-2 remain to be determined. Fatty Acids, Omega-3 26-41 cytochrome c oxidase I, mitochondrial Rattus norvegicus 51-56 10024686-9 1999 The mechanism(s) by which n-3 fatty acids suppress COX-1 and COX-2 remain to be determined. Fatty Acids, Omega-3 26-41 cytochrome c oxidase II, mitochondrial Rattus norvegicus 61-66 9888867-3 1999 Previously, we demonstrated that dietary omega-3 fatty acids reduce platelet-derived growth factor (PDGF)-A and PDGF-B mRNA levels in unstimulated, human mononuclear cells (MNCs). Fatty Acids, Omega-3 41-60 platelet derived growth factor subunit A Homo sapiens 100-107 10065739-1 1999 The objective of this study was to investigate the impact of feeding mice a diet rich in n-3 polyunsaturated fatty acids (PUFA) from fish oil on the interleukin-12 (IL-12) and interferon-gamma (IFNgamma) production during the early stage of an infectious challenge with Listeria monocytogenes. Fatty Acids, Omega-3 89-120 interferon gamma Mus musculus 194-202 10338684-0 1999 Small supplements of N-3 fatty acids change serum low density lipoprotein composition by decreasing phospholid and apolipoprotein B concentrations in young adult women. Fatty Acids, Omega-3 21-36 apolipoprotein B Homo sapiens 115-131 9888872-0 1999 Administration of n-3 fatty acids in the diets of rats or directly to hepatocyte cultures results in different effects on hepatocellular ApoB metabolism and secretion. Fatty Acids, Omega-3 18-33 apolipoprotein B Rattus norvegicus 137-141 9888872-4 1999 When n-3 fatty acid was given via the dietary route, apoB-48 very low density lipoprotein (VLDL) secretion was inhibited, but there was no effect on the secretion of apoB-100 VLDL. Fatty Acids, Omega-3 5-19 apolipoprotein B Rattus norvegicus 53-60 9888872-10 1999 In addition, whereas dietary administration of n-3 fatty acid gave rise to decreased net synthesis and degradation of apoB-48, direct administration in vitro resulted in increased degradation with no effect on net synthesis. Fatty Acids, Omega-3 47-61 apolipoprotein B Rattus norvegicus 118-125 9888872-11 1999 We conclude that the effects of n-3 fatty acids on hepatic lipid and apoB metabolism differ according to whether they are administered in vivo, via the dietary route, or in vitro, via direct addition to hepatocyte cultures. Fatty Acids, Omega-3 32-47 apolipoprotein B Rattus norvegicus 69-73 9888867-3 1999 Previously, we demonstrated that dietary omega-3 fatty acids reduce platelet-derived growth factor (PDGF)-A and PDGF-B mRNA levels in unstimulated, human mononuclear cells (MNCs). Fatty Acids, Omega-3 41-60 platelet derived growth factor subunit B Homo sapiens 112-118 9888867-5 1999 In unstimulated MNCs, mRNA steady-state levels of PDGF-A, PDGF-B, and MCP-1 were reduced by 25+/-10%, 31+/-13%, and 40+/-14%, respectively, after omega-3 fatty acid ingestion, as assessed by quantitative polymerase chain reaction (all P<0.05). Fatty Acids, Omega-3 146-164 platelet derived growth factor subunit A Homo sapiens 50-56 9888867-5 1999 In unstimulated MNCs, mRNA steady-state levels of PDGF-A, PDGF-B, and MCP-1 were reduced by 25+/-10%, 31+/-13%, and 40+/-14%, respectively, after omega-3 fatty acid ingestion, as assessed by quantitative polymerase chain reaction (all P<0.05). Fatty Acids, Omega-3 146-164 platelet derived growth factor subunit B Homo sapiens 58-64 9888867-5 1999 In unstimulated MNCs, mRNA steady-state levels of PDGF-A, PDGF-B, and MCP-1 were reduced by 25+/-10%, 31+/-13%, and 40+/-14%, respectively, after omega-3 fatty acid ingestion, as assessed by quantitative polymerase chain reaction (all P<0.05). Fatty Acids, Omega-3 146-164 C-C motif chemokine ligand 2 Homo sapiens 70-75 9888867-9 1999 We conclude that human gene expression for PDGF-A, PDGF-B, and MCP-1, factors thought relevant to atherosclerosis, is constitutive, is constant, and can be reduced only by dietary omega-3 fatty acids in unstimulated and adherence-activated monocytes. Fatty Acids, Omega-3 180-199 platelet derived growth factor subunit A Homo sapiens 43-49 9888867-9 1999 We conclude that human gene expression for PDGF-A, PDGF-B, and MCP-1, factors thought relevant to atherosclerosis, is constitutive, is constant, and can be reduced only by dietary omega-3 fatty acids in unstimulated and adherence-activated monocytes. Fatty Acids, Omega-3 180-199 platelet derived growth factor subunit B Homo sapiens 51-57 9888867-9 1999 We conclude that human gene expression for PDGF-A, PDGF-B, and MCP-1, factors thought relevant to atherosclerosis, is constitutive, is constant, and can be reduced only by dietary omega-3 fatty acids in unstimulated and adherence-activated monocytes. Fatty Acids, Omega-3 180-199 C-C motif chemokine ligand 2 Homo sapiens 63-68 10435119-1 1999 Polyunsaturated fatty acids of omega-3 series (omega-3 or n-3 PUFA), especially long chain EPA and DHA, exert strong positive influence on human health. Fatty Acids, Omega-3 31-38 pumilio RNA binding family member 3 Homo sapiens 62-66 10435119-1 1999 Polyunsaturated fatty acids of omega-3 series (omega-3 or n-3 PUFA), especially long chain EPA and DHA, exert strong positive influence on human health. Fatty Acids, Omega-3 47-54 pumilio RNA binding family member 3 Homo sapiens 62-66 9823904-6 1998 RESULTS: Individuals with a genetic susceptibility to insulin resistance show triggering of hyperinsulinaemia following excessive weight gain or long-term diet high in saturated fat. Fatty Acids, Omega-3 168-181 insulin Homo sapiens 54-61 10048767-0 1999 Dietary omega-3 polyunsaturated fatty acids reduce IFN-gamma receptor expression in mice. Fatty Acids, Omega-3 8-43 interferon gamma Mus musculus 51-60 10048767-1 1999 Enrichment of immune cells in vivo or in vitro with omega-3 polyunsaturated fatty acid (n-3 PUFA) has been reported to diminish their response to interferon-y (IFN-gamma). Fatty Acids, Omega-3 52-86 interferon gamma Mus musculus 160-169 10048767-1 1999 Enrichment of immune cells in vivo or in vitro with omega-3 polyunsaturated fatty acid (n-3 PUFA) has been reported to diminish their response to interferon-y (IFN-gamma). Fatty Acids, Omega-3 88-96 interferon gamma Mus musculus 160-169 10578489-8 1999 Moreover, we observed an increase in the activity of palmitoyl-CoA oxidase, the limiting enzyme of peroxisomal beta-oxidation, the preferential metabolic pathway of n-3 polyunsaturated fatty acid. Fatty Acids, Omega-3 165-195 acyl-CoA oxidase 1 Rattus norvegicus 53-74 9823904-11 1998 Recent research suggests that a diet high in n-3 polyunsaturated fatty acids may reduce the risk of developing insulin resistance. Fatty Acids, Omega-3 45-76 insulin Homo sapiens 111-118 9637532-0 1998 Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. Fatty Acids, Omega-3 131-146 coagulation factor III, tissue factor Homo sapiens 30-43 10096112-6 1998 Dietary supplementation with n-3 PUFA also resulted in augmentation of depressed neutrophil chemotaxis to LTB4 and FMLP. Fatty Acids, Omega-3 29-37 formyl peptide receptor 1 Homo sapiens 115-119 9733153-1 1998 Several studies have shown that n-3 polyunsaturated fatty acids (n-3 PUFA) are able to lower blood pressure (BP) in humans, but large doses of fish oils have been often used. Fatty Acids, Omega-3 32-63 pumilio RNA binding family member 3 Homo sapiens 69-73 9637532-0 1998 Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. Fatty Acids, Omega-3 131-146 prostaglandin-endoperoxide synthase 1 Homo sapiens 83-100 9598830-6 1998 In 27 patients who received purified n-3 fatty acid (Omacor) 4 g/d for > or =7 months, triglyceride level was reduced by 47+/-4.6%, sICAM-1 level was reduced by 9+/-3.4% (P=.02), and soluble E-selectin level was reduced by 16+/-3.2% (P<.0001), with the greatest reduction in diabetic patients. Fatty Acids, Omega-3 37-51 selectin E Homo sapiens 194-204 9566646-6 1998 Addition of omega-3 fatty acids (4 g day[-1]) further decreased serum triacylglycerols (P = 0.007), total cholesterol (P = 0.052) and apolipoprotein E (P = 0.035). Fatty Acids, Omega-3 12-31 apolipoprotein E Homo sapiens 134-150 9642696-2 1998 N-3 polyunsaturated fatty acid (n-3 PUFA) were reported to increase the survival rate, and to improve the nutritional and immune status of septic or burned animals. Fatty Acids, Omega-3 0-30 pumilio RNA binding family member 3 Homo sapiens 36-40 9654402-0 1998 Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. Fatty Acids, Omega-3 18-33 interleukin 2 Mus musculus 37-50 9654402-0 1998 Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. Fatty Acids, Omega-3 18-33 interleukin 2 Mus musculus 55-68 9425302-2 1997 Western blot analysis indicated that the mass of the constitutive isoform of PGH synthase (PGH synthase 1), but not PGI2 synthase, was significantly reduced in n-3 fatty acid-enriched cells. Fatty Acids, Omega-3 160-174 prostaglandin-endoperoxide synthase 1 Bos taurus 91-105 9657667-1 1998 n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine. Fatty Acids, Omega-3 0-15 patchy fur Mus musculus 22-48 9657667-13 1998 The present study also suggests that dietary supplementation with n-3 fatty acids suppress intestinal PAF and LTB4 generation in hypoxia-induced bowel necrosis. Fatty Acids, Omega-3 66-81 patchy fur Mus musculus 102-105 9437192-15 1997 An increased intake of long chain n-3 fatty acids decreases fasting plasma triglyceride and apoprotein AII concentrations and increases HDL2 cholesterol concentrations and results in less postprandial lipemia but leads to an increase in VIIc. Fatty Acids, Omega-3 34-49 junctophilin 3 Homo sapiens 136-140 9459135-0 1997 Effects of omega 3 fatty acids on receptor tyrosine kinase and PLC activities in EMT6 cells. Fatty Acids, Omega-3 11-30 TYRO3 protein tyrosine kinase 3 Mus musculus 34-58 9409332-2 1997 In contrast, the n-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid, have been shown to reduce apoB secretion by increasing its intracellular degradation in rat hepatocytes. Fatty Acids, Omega-3 17-32 apolipoprotein B Rattus norvegicus 114-118 9466128-2 1997 Reductions in the production of pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation. Fatty Acids, Omega-3 200-214 interleukin 1 beta Homo sapiens 59-77 9466128-2 1997 Reductions in the production of pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation. Fatty Acids, Omega-3 200-214 interleukin 6 Homo sapiens 152-156 9542772-3 1997 n-3 fatty acid supplementation did not significantly decrease total cholesterol and triglyceride levels but markedly decreased the Apo A1 and Apo B concentrations (12.7%, p < 0.01 and 23.1%, p < 0.001, respectively), while the Apo A1/Apo B ratio significantly increased (14.8%, p < 0.02). Fatty Acids, Omega-3 0-14 apolipoprotein A1 Homo sapiens 131-137 9542772-3 1997 n-3 fatty acid supplementation did not significantly decrease total cholesterol and triglyceride levels but markedly decreased the Apo A1 and Apo B concentrations (12.7%, p < 0.01 and 23.1%, p < 0.001, respectively), while the Apo A1/Apo B ratio significantly increased (14.8%, p < 0.02). Fatty Acids, Omega-3 0-14 apolipoprotein B Homo sapiens 142-147 9542772-3 1997 n-3 fatty acid supplementation did not significantly decrease total cholesterol and triglyceride levels but markedly decreased the Apo A1 and Apo B concentrations (12.7%, p < 0.01 and 23.1%, p < 0.001, respectively), while the Apo A1/Apo B ratio significantly increased (14.8%, p < 0.02). Fatty Acids, Omega-3 0-14 apolipoprotein A1 Homo sapiens 233-239 9542772-3 1997 n-3 fatty acid supplementation did not significantly decrease total cholesterol and triglyceride levels but markedly decreased the Apo A1 and Apo B concentrations (12.7%, p < 0.01 and 23.1%, p < 0.001, respectively), while the Apo A1/Apo B ratio significantly increased (14.8%, p < 0.02). Fatty Acids, Omega-3 0-14 apolipoprotein B Homo sapiens 240-245 9459135-0 1997 Effects of omega 3 fatty acids on receptor tyrosine kinase and PLC activities in EMT6 cells. Fatty Acids, Omega-3 11-30 perlecan (heparan sulfate proteoglycan 2) Mus musculus 63-66 9459135-1 1997 The effects of omega 3 fatty acids and epidermal growth factor (EGF) on the activity of receptor tyrosine kinase (RTK) and phospholipase C (phosphatidylinositol (PI)-specific PLC) were examined in EMT6 cells. Fatty Acids, Omega-3 15-34 TYRO3 protein tyrosine kinase 3 Mus musculus 88-112 9459135-1 1997 The effects of omega 3 fatty acids and epidermal growth factor (EGF) on the activity of receptor tyrosine kinase (RTK) and phospholipase C (phosphatidylinositol (PI)-specific PLC) were examined in EMT6 cells. Fatty Acids, Omega-3 15-34 TYRO3 protein tyrosine kinase 3 Mus musculus 114-117 9459135-3 1997 Treatment of the EMT6 cells with omega 3 fatty acids resulted in a 62% increase in RTK activity and a 67% increase in PI-specific PLC activity. Fatty Acids, Omega-3 33-52 TYRO3 protein tyrosine kinase 3 Mus musculus 83-86 9459135-3 1997 Treatment of the EMT6 cells with omega 3 fatty acids resulted in a 62% increase in RTK activity and a 67% increase in PI-specific PLC activity. Fatty Acids, Omega-3 33-52 perlecan (heparan sulfate proteoglycan 2) Mus musculus 130-133 9459135-4 1997 When EGF was added to incubations for RTK activity, it stimulated the RTK activity 40% in the control cells and 130% in the omega 3-treated cells. Fatty Acids, Omega-3 124-131 epidermal growth factor Homo sapiens 5-8 9459135-4 1997 When EGF was added to incubations for RTK activity, it stimulated the RTK activity 40% in the control cells and 130% in the omega 3-treated cells. Fatty Acids, Omega-3 124-131 TYRO3 protein tyrosine kinase 3 Mus musculus 38-41 9459135-4 1997 When EGF was added to incubations for RTK activity, it stimulated the RTK activity 40% in the control cells and 130% in the omega 3-treated cells. Fatty Acids, Omega-3 124-131 TYRO3 protein tyrosine kinase 3 Mus musculus 70-73 9459135-6 1997 Thus, treating EMT6 cells with omega 3 fatty acids seems to increase RTK activity and PI-specific PLC activity to a similar extent, but has differential effects on the ability of these enzyme activities to be stimulated by EGF. Fatty Acids, Omega-3 31-50 TYRO3 protein tyrosine kinase 3 Mus musculus 69-72 9459135-6 1997 Thus, treating EMT6 cells with omega 3 fatty acids seems to increase RTK activity and PI-specific PLC activity to a similar extent, but has differential effects on the ability of these enzyme activities to be stimulated by EGF. Fatty Acids, Omega-3 31-50 perlecan (heparan sulfate proteoglycan 2) Mus musculus 98-101 9459135-6 1997 Thus, treating EMT6 cells with omega 3 fatty acids seems to increase RTK activity and PI-specific PLC activity to a similar extent, but has differential effects on the ability of these enzyme activities to be stimulated by EGF. Fatty Acids, Omega-3 31-50 epidermal growth factor Mus musculus 223-226 9350068-1 1997 The effect of three different doses of n-3 polyunsaturated fatty acids (PUFA) on endothelin-1 (ET-1) was studied. Fatty Acids, Omega-3 39-70 endothelin 1 Homo sapiens 81-93 9322579-2 1997 In human experiments, n-3 fatty acids may improve many of the metabolic sequelae of insulin resistance by lowering blood pressure and triacylglycerol concentrations. Fatty Acids, Omega-3 22-37 insulin Homo sapiens 84-91 9430382-4 1997 Good insulin action is associated with an increased proportion of n-3 fatty acids, low saturates, a low n-6/n-3 ratio and possibly increased monounsaturates. Fatty Acids, Omega-3 66-81 insulin Homo sapiens 5-12 9430382-7 1997 However, the n-3 fatty acids might also be a key to amelioration of both insulin resistance and thrombosis. Fatty Acids, Omega-3 13-28 insulin Homo sapiens 73-80 9430382-12 1997 Linoleic acid, in high amounts, is known to inhibit the delta6 fatty acid desaturase enzyme and with the competition between n-6 and n-3 fatty acids for the enzymes of desaturation and elongation it does focus on a high n-6/n-3 ratio as a critical factor in both insulin resistance and atherosclerosis. Fatty Acids, Omega-3 133-148 insulin Homo sapiens 263-270 9350068-1 1997 The effect of three different doses of n-3 polyunsaturated fatty acids (PUFA) on endothelin-1 (ET-1) was studied. Fatty Acids, Omega-3 39-70 endothelin 1 Homo sapiens 95-99 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. Fatty Acids, Omega-3 16-25 interleukin 6 Homo sapiens 107-111 9181465-1 1997 The objective of this study was to investigate the impact of feeding mice a diet rich in n-3 polyunsaturated fatty acids (PUFA) from fish oil on the interferon-gamma (IFN-gamma) response during an active infection with Listeria monocytogenes. Fatty Acids, Omega-3 89-120 interferon gamma Mus musculus 167-176 9101428-0 1997 Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B-48. Fatty Acids, Omega-3 75-90 apolipoprotein B Rattus norvegicus 168-187 9042869-9 1997 CONCLUSION: Our data provide evidence that a total parenteral nutrition enriched with omega-3 fatty acids modulates the lipid mediator pattern and systemic tumor necrosis factor-alpha levels. Fatty Acids, Omega-3 86-105 tumor necrosis factor Homo sapiens 156-183 9015191-3 1997 In this study, we investigated how n-3 fatty acids altered the signaling pathway of the lipid-based mediator platelet-activating factor (PAF). Fatty Acids, Omega-3 35-50 patchy fur Mus musculus 137-140 9015191-4 1997 Macrophages from mice fed a diet containing n-3 fatty acids showed a greater increase in PAF-induced intracellular Ca2+ mobilization than macrophages from mice fed an n-6 fatty acid-rich diet. Fatty Acids, Omega-3 44-59 patchy fur Mus musculus 89-92 9015191-10 1997 Collectively, these results showed that n-3 fatty acids can enhance the PAF-signaling pathway in macrophages by increasing the activation potential of phospholipase C, without affecting PAF receptor number and affinity. Fatty Acids, Omega-3 40-55 patchy fur Mus musculus 72-75 9290048-0 1997 Decreased secretion of very-low-density lipoprotein triacylglycerol and apolipoprotein B is associated with decreased intracellular triacylglycerol lipolysis in hepatocytes derived from rats fed orotic acid or n-3 fatty acids. Fatty Acids, Omega-3 210-225 apolipoprotein B Rattus norvegicus 72-88 9140033-11 1997 We speculate that dietary n-3 fatty acids suppressed PGE2-related responses, including a PGE2-dependent negative feedback on TNF-alpha production, which resulted in differential modulation of sickness behavior depending on the locus of inflammation. Fatty Acids, Omega-3 26-41 tumor necrosis factor Mus musculus 125-134 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. Fatty Acids, Omega-3 16-25 tumor necrosis factor Homo sapiens 151-160 9547608-6 1997 The addition of n-3 PUFAs in culture medium (100 ug/ml DHA or EPA) significantly reduces the production of IL-6 by unstimulated EC; or stimulated with TNF-alpha; IL-4 pg/ml); LPS or depleted PBL respectively for DHA and EPA, whereas the n-6 PUFAs (Arachidonic acid), even used at the highest concentration, was ineffective. Fatty Acids, Omega-3 16-25 interleukin 4 Homo sapiens 162-166 9040541-0 1997 Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide. Fatty Acids, Omega-3 8-41 Fas (TNF receptor superfamily member 6) Mus musculus 58-77 9040541-0 1997 Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide. Fatty Acids, Omega-3 8-41 interleukin 2 Mus musculus 79-92 8955208-0 1996 Dietary n-3 fatty acids increase spleen size and postendotoxin circulating TNF in mice; role of macrophages, macrophage precursors, and colony-stimulating factor-1. Fatty Acids, Omega-3 8-23 tumor necrosis factor Mus musculus 75-78 8981628-1 1996 The metabolism of [3H]arachidonic acid (3H-AA) by control and omega-3 polyunsaturated fatty acid (n-3 PUFA)-enriched piglet alveolar macrophages (AM) was studied after a 4 and 24 h labeling period. Fatty Acids, Omega-3 62-96 pumilio RNA binding family member 3 Homo sapiens 102-106 8970622-5 1996 When EC were pretreated with (n-3) PUFAs for 18 hr, washed, and then stimulated by TNF alpha, IL-4, or lipopolysaccharide, PBL adhesion was also significantly reduced compared with controls. Fatty Acids, Omega-3 29-40 tumor necrosis factor Homo sapiens 83-92 8970622-5 1996 When EC were pretreated with (n-3) PUFAs for 18 hr, washed, and then stimulated by TNF alpha, IL-4, or lipopolysaccharide, PBL adhesion was also significantly reduced compared with controls. Fatty Acids, Omega-3 29-40 interleukin 4 Homo sapiens 94-98 8970622-7 1996 Cytofluorometry and immunoenzymatic analyses indicated that pretreatment of EC with (n-3) PUFAs before their activation significantly reduced the EC-induced expression of vascular cell adhesion molecule 1, whereas the level of expression of intercellular adhesion molecule 1 and E-selectin was not modified. Fatty Acids, Omega-3 84-95 vascular cell adhesion molecule 1 Homo sapiens 171-204 8970622-7 1996 Cytofluorometry and immunoenzymatic analyses indicated that pretreatment of EC with (n-3) PUFAs before their activation significantly reduced the EC-induced expression of vascular cell adhesion molecule 1, whereas the level of expression of intercellular adhesion molecule 1 and E-selectin was not modified. Fatty Acids, Omega-3 84-95 intercellular adhesion molecule 1 Homo sapiens 241-274 8970622-7 1996 Cytofluorometry and immunoenzymatic analyses indicated that pretreatment of EC with (n-3) PUFAs before their activation significantly reduced the EC-induced expression of vascular cell adhesion molecule 1, whereas the level of expression of intercellular adhesion molecule 1 and E-selectin was not modified. Fatty Acids, Omega-3 84-95 selectin E Homo sapiens 279-289 8655902-10 1996 CONCLUSION: Increasing dietary intakes of n-3 polyunsaturated fatty acids, L-arginine, and RNA increased body weight, possibly by modulating the negative effects of TNF. Fatty Acids, Omega-3 42-73 tumor necrosis factor Homo sapiens 165-168 8828435-0 1996 The effect of high dietary n-3 fatty acid supplementation on angiotensin II pressor response in human pregnancy. Fatty Acids, Omega-3 27-41 angiotensinogen Homo sapiens 61-75 8828435-1 1996 OBJECTIVE: Our purpose was to evaluate the effects of n-3 fatty acid supplementation on vascular reactivity as measured by the angiotensin II sensitivity test. Fatty Acids, Omega-3 54-68 angiotensinogen Homo sapiens 127-141 8828435-9 1996 CONCLUSIONS: High-dose n-3 fatty acid supplementation resulted in an enhancement of the pregnancy-acquired refractoriness to angiotensin II. Fatty Acids, Omega-3 23-37 angiotensinogen Homo sapiens 125-139 8816853-10 1996 Raised levels of fatty acid synthase mRNA in liver and brown adipose tissue of control rats fed high sucrose diet were suppressed by consumption of diet high in n-3 fatty acids. Fatty Acids, Omega-3 161-176 fatty acid synthase Rattus norvegicus 17-36 8862462-5 1996 Specific granule release and chemiluminescence response in cord blood neutrophils were evident at 0.1-0.5 microgram/ml of PUFA, concentrations normally found in vivo during inflammation or following diets enriched with n-3 fatty acids. Fatty Acids, Omega-3 219-234 pumilio RNA binding family member 3 Homo sapiens 122-126 8603262-2 1996 Dietary n-3 fatty acids reduce the production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) by peripheral blood mononuclear cells (PBMC) in normal humans and prevent IL-1 and TNF anorexia in animals. Fatty Acids, Omega-3 8-23 tumor necrosis factor Homo sapiens 74-95 8603262-2 1996 Dietary n-3 fatty acids reduce the production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) by peripheral blood mononuclear cells (PBMC) in normal humans and prevent IL-1 and TNF anorexia in animals. Fatty Acids, Omega-3 8-23 tumor necrosis factor Homo sapiens 97-100 8729089-3 1996 The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid. Fatty Acids, Omega-3 51-66 interleukin 1 beta Mus musculus 167-185 8729089-3 1996 The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid. Fatty Acids, Omega-3 51-66 interleukin 1 beta Mus musculus 187-196 8729089-3 1996 The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid. Fatty Acids, Omega-3 51-65 interleukin 1 beta Mus musculus 167-185 8729089-3 1996 The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid. Fatty Acids, Omega-3 51-65 interleukin 1 beta Mus musculus 187-196 8701396-0 1996 Increased plasma levels of tissue factor pathway inhibitor (TFPI) after n-3 polyunsaturated fatty acids supplementation in patients with chronic atherosclerotic disease. Fatty Acids, Omega-3 72-103 tissue factor pathway inhibitor Homo sapiens 27-58 8701396-0 1996 Increased plasma levels of tissue factor pathway inhibitor (TFPI) after n-3 polyunsaturated fatty acids supplementation in patients with chronic atherosclerotic disease. Fatty Acids, Omega-3 72-103 tissue factor pathway inhibitor Homo sapiens 60-64 8701396-1 1996 This double-blind, randomised, controlled study examined the effect of a daily dosage of 3 g n-3 polyunsaturated fatty acids (n-3 PUFA) on plasma lipids and some haemostatic factors in 40 patients with chronic atherosclerotic diseases. Fatty Acids, Omega-3 93-124 pumilio RNA binding family member 3 Homo sapiens 130-134 8850218-11 1996 Thus, dietary n-3 fatty acids may significantly alter macrophage tumoricidal activation and TNF-alpha production through the modulation of PGE2 production and signal transduction. Fatty Acids, Omega-3 14-29 tumor necrosis factor Mus musculus 92-101 8852484-3 1996 Omega-3 polyunsaturated fatty acids (omega-3 FA) have been reported to decrease Lp(a) concentrations in nonrenal subjects. Fatty Acids, Omega-3 0-35 lipoprotein(a) Homo sapiens 80-85 8852484-3 1996 Omega-3 polyunsaturated fatty acids (omega-3 FA) have been reported to decrease Lp(a) concentrations in nonrenal subjects. Fatty Acids, Omega-3 37-47 lipoprotein(a) Homo sapiens 80-85 7569731-5 1995 We investigated the long-term effects of supplementation with n-3 polyunsaturated fatty acids (n-3 PUFAs) on the Lp(a) concentrations. Fatty Acids, Omega-3 62-93 lipoprotein(a) Homo sapiens 113-118 8719931-0 1995 Omega-3 fatty acids suppress the enhanced production of 5-lipoxygenase products from polymorph neutrophil granulocytes in cystic fibrosis. Fatty Acids, Omega-3 0-19 arachidonate 5-lipoxygenase Homo sapiens 56-70 8587238-9 1995 Moreover, angiotensin II-stimulated phospholipid turnover was attenuated in intact glomeruli pretreated with omega-3 FAs. Fatty Acids, Omega-3 109-120 angiotensinogen Rattus norvegicus 10-24 7556148-6 1995 When rats were fed isocaloric diets enriched in saturated fat (hydrogenated coconut oil), n-6 PUFAs (safflower oil) or n-3 PUFAs (fish oil), a significant decrease in liver apo A-I and apo A-II mRNA levels was only observed after fish oil feeding. Fatty Acids, Omega-3 119-128 apolipoprotein A1 Rattus norvegicus 173-193 7562078-1 1995 The hypothesis tested was that dietary medium-chain or (n-3) polyunsaturated fatty acids, when compared with (n-6) polyunsaturated fatty acids, alter plasma triacylglycerol levels by affecting hepatic triacylglycerol synthesis as reflected by the activities of acetyl-CoA carboxylase, fatty acid synthase and diacylglycerol acyltransferase in liver. Fatty Acids, Omega-3 55-88 fatty acid synthase Rattus norvegicus 285-304 7562078-1 1995 The hypothesis tested was that dietary medium-chain or (n-3) polyunsaturated fatty acids, when compared with (n-6) polyunsaturated fatty acids, alter plasma triacylglycerol levels by affecting hepatic triacylglycerol synthesis as reflected by the activities of acetyl-CoA carboxylase, fatty acid synthase and diacylglycerol acyltransferase in liver. Fatty Acids, Omega-3 55-88 diacylglycerol O-acyltransferase 1 Rattus norvegicus 309-339 7569731-5 1995 We investigated the long-term effects of supplementation with n-3 polyunsaturated fatty acids (n-3 PUFAs) on the Lp(a) concentrations. Fatty Acids, Omega-3 95-104 lipoprotein(a) Homo sapiens 113-118 7794954-1 1995 Here we test whether the incorporation of docosahexaenoic acid (DHA, 22:6), an (n-3) fatty acid, into lymphocyte membranes affects the expression of the surface proteins Thy-1.2 and CD8. Fatty Acids, Omega-3 79-95 thymus cell antigen 1, theta Mus musculus 170-177 7794954-4 1995 As (n-3) fatty acid incorporation into the lymphocytes increased, the expression of one Thy-1.2 epitope and one CD8 epitope decreased; the expression of two CD8 epitopes increased. Fatty Acids, Omega-3 3-19 thymus cell antigen 1, theta Mus musculus 88-95 7794954-6 1995 The decrease in Thy-1.2 expression was sustained for more than a week after removal of (n-3) fatty acids from the diet, most likely due to retention of membrane-bound (n-3) fatty acids. Fatty Acids, Omega-3 87-104 thymus cell antigen 1, theta Mus musculus 16-23 7794954-6 1995 The decrease in Thy-1.2 expression was sustained for more than a week after removal of (n-3) fatty acids from the diet, most likely due to retention of membrane-bound (n-3) fatty acids. Fatty Acids, Omega-3 167-184 thymus cell antigen 1, theta Mus musculus 16-23 7658148-5 1995 In hamsters fed n-3 fatty acids, changes in receptor-dependent LDL transport were accompanied by parallel changes in LDL receptor mRNA, indicating regulation of the receptor at the pretranslational level. Fatty Acids, Omega-3 16-31 low density lipoprotein receptor Rattus norvegicus 117-129 7740525-0 1995 Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. Fatty Acids, Omega-3 56-75 interleukin 6 Homo sapiens 125-138 7539633-9 1995 CONCLUSION: Supplementation of an enteral diet with arginine, RNA and omega-3 fatty acids can modulate the acute phase reaction as indicated by the reduction in concentrations of TNF-alpha and IL-6 in the group fed the supplemented diet. Fatty Acids, Omega-3 70-89 tumor necrosis factor Homo sapiens 179-188 7713324-0 1995 Plasma endothelin-1 immunoreactivity is increased following long-term dietary supplementation with omega-3 fatty acids in microalbuminuric IDDM patients. Fatty Acids, Omega-3 99-118 endothelin 1 Homo sapiens 7-19 7539633-9 1995 CONCLUSION: Supplementation of an enteral diet with arginine, RNA and omega-3 fatty acids can modulate the acute phase reaction as indicated by the reduction in concentrations of TNF-alpha and IL-6 in the group fed the supplemented diet. Fatty Acids, Omega-3 70-89 interleukin 6 Homo sapiens 193-197 7743372-0 1994 Dietary source of omega-3 fatty acids affects endotoxin-induced peritoneal macrophage tumor necrosis factor and eicosanoid synthesis. Fatty Acids, Omega-3 18-37 tumor necrosis factor-like Rattus norvegicus 86-107 8789319-4 1995 Furthermore, marine fish oil (FO) rich in n-3 polyunsaturated fatty acids (PUFA), added to the basal diet (30 wt % of n-3 PUFA) reduced the GLUT4 protein levels (B: 100 +/- 3 vs B+FO: 42 +/- 4%, p < 0.005) in control rats to values similar to those found in HTG rats (B: 46 +/- 4%). Fatty Acids, Omega-3 42-73 solute carrier family 2 member 4 Rattus norvegicus 140-145 7889894-1 1994 OBJECTIVES: The effect of a fish oil preparation, K-85, in which the omega-3 fatty acid content was concentrated to 92% of total fat, on serum lipid and lipoprotein concentrations was investigated in patients with primary hypertriglyceridaemia. Fatty Acids, Omega-3 69-87 keratin 85 Homo sapiens 50-54 7918310-0 1994 n-3 fatty acid ethyl ester administration to healthy subjects and to hypertriglyceridemic patients reduces tissue factor activity in adherent monocytes. Fatty Acids, Omega-3 0-14 coagulation factor III, tissue factor Homo sapiens 107-120 7918310-3 1994 In this study we evaluated the effects of administration of n-3 fatty acid ethyl esters to healthy volunteers and to hypertriglyceridemic patients on tissue factor activity (TF activity) in adherent monocytes. Fatty Acids, Omega-3 60-74 coagulation factor III, tissue factor Homo sapiens 150-163 7824535-3 1994 The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo. Fatty Acids, Omega-3 4-19 interleukin 1 alpha Homo sapiens 143-156 7926817-2 1994 SR1) leaf cDNA library using, as a hybridization probe, a cDNA fragment from the gene (fad7) encoding Arabidopsis thaliana chloroplast omega-3 fatty acid (FA) desaturase. Fatty Acids, Omega-3 135-153 signal responsive 1 Arabidopsis thaliana 0-3 7926817-2 1994 SR1) leaf cDNA library using, as a hybridization probe, a cDNA fragment from the gene (fad7) encoding Arabidopsis thaliana chloroplast omega-3 fatty acid (FA) desaturase. Fatty Acids, Omega-3 135-153 fatty acid desaturase 7 Arabidopsis thaliana 87-91 7824535-3 1994 The n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can suppress T-cell proliferation and the production of interleukin-1, interleukin-2, and tumor necrosis factor by these cells both in vitro and in vivo. Fatty Acids, Omega-3 4-19 interleukin 2 Homo sapiens 158-171 7939369-7 1994 In both groups combined, the recorded changes in serum triglyceride and serum insulin levels were negatively correlated with the change in serum phospholipid n-3 fatty acids (r = -0.35, p = 0.008 and r = -0.32, p = 0.016, respectively). Fatty Acids, Omega-3 158-173 insulin Homo sapiens 78-85 8034600-1 1994 We have previously reported that in primary rat hepatocytes, n-3 fatty acid (either eicosapentaenoic or docosahexaenoic) stimulates intracellular degradation of apoprotein B100 (apoB100) and apoB48 (Wang, H., Chen, X., and Fisher, E.A. Fatty Acids, Omega-3 61-75 apolipoprotein B Rattus norvegicus 161-176 8034600-1 1994 We have previously reported that in primary rat hepatocytes, n-3 fatty acid (either eicosapentaenoic or docosahexaenoic) stimulates intracellular degradation of apoprotein B100 (apoB100) and apoB48 (Wang, H., Chen, X., and Fisher, E.A. Fatty Acids, Omega-3 61-75 apolipoprotein B Rattus norvegicus 178-185 8034600-1 1994 We have previously reported that in primary rat hepatocytes, n-3 fatty acid (either eicosapentaenoic or docosahexaenoic) stimulates intracellular degradation of apoprotein B100 (apoB100) and apoB48 (Wang, H., Chen, X., and Fisher, E.A. Fatty Acids, Omega-3 61-75 apolipoprotein B Rattus norvegicus 191-197 8034600-11 1994 We conclude that the ability of the n-3 fatty acids to promote apoB degradation correlated with the degree of lipidation of the secreted apoB, consistent with specialized intracellular pathways for the degradation of apoB and the assembly of buoyant, apoB-containing lipoproteins. Fatty Acids, Omega-3 36-51 apolipoprotein B Homo sapiens 63-67 8034600-11 1994 We conclude that the ability of the n-3 fatty acids to promote apoB degradation correlated with the degree of lipidation of the secreted apoB, consistent with specialized intracellular pathways for the degradation of apoB and the assembly of buoyant, apoB-containing lipoproteins. Fatty Acids, Omega-3 36-51 apolipoprotein B Homo sapiens 137-141 8034600-11 1994 We conclude that the ability of the n-3 fatty acids to promote apoB degradation correlated with the degree of lipidation of the secreted apoB, consistent with specialized intracellular pathways for the degradation of apoB and the assembly of buoyant, apoB-containing lipoproteins. Fatty Acids, Omega-3 36-51 apolipoprotein B Homo sapiens 137-141 8034600-11 1994 We conclude that the ability of the n-3 fatty acids to promote apoB degradation correlated with the degree of lipidation of the secreted apoB, consistent with specialized intracellular pathways for the degradation of apoB and the assembly of buoyant, apoB-containing lipoproteins. Fatty Acids, Omega-3 36-51 apolipoprotein B Homo sapiens 137-141 7968719-1 1994 N-3 polyunsaturated fatty acids reduce the synthesis of IL-1, the main molecule responsible for fever. Fatty Acids, Omega-3 0-31 interleukin 1 alpha Homo sapiens 56-60 8069236-3 1994 Cytochrome P 450 level was decreased by n-3 PUFA (Polyunsaturated fatty acid) deficiency. Fatty Acids, Omega-3 40-48 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 8066866-2 1994 The effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with active rheumatoid arthritis was evaluated in a multicentre, randomized and double blind study. Fatty Acids, Omega-3 43-74 pumilio RNA binding family member 3 Homo sapiens 80-84 8070921-8 1994 Our results demonstrate that an increased dietary intake of (n-3)-PUFA suppress LTB4 and PGE2 synthesis. Fatty Acids, Omega-3 60-70 prostaglandin reductase 1 Cavia porcellus 80-84 8050452-0 1994 Dietary supplementation with very long-chain n-3 fatty acids in man decreases expression of the interleukin-2 receptor (CD25) on mitogen-stimulated lymphocytes from patients with inflammatory skin diseases. Fatty Acids, Omega-3 45-60 interleukin 2 Homo sapiens 96-109 8050452-0 1994 Dietary supplementation with very long-chain n-3 fatty acids in man decreases expression of the interleukin-2 receptor (CD25) on mitogen-stimulated lymphocytes from patients with inflammatory skin diseases. Fatty Acids, Omega-3 45-60 interleukin 2 receptor subunit alpha Homo sapiens 120-124 8118867-3 1994 In this study, production of the inflammatory monokine, tumor necrosis factor-alpha (TNF alpha), by isolated murine macrophages was assessed following a 3-week feeding with diets containing either 10% menhaden fish oil as a source of n-3 fatty acids or, as a control and source of n-6 fatty acids, 10% safflower oil. Fatty Acids, Omega-3 234-249 tumor necrosis factor Mus musculus 56-83 8125741-9 1994 Species having n-3 fatty acids in the sn-2 position contributed 59%, 36%, and 70% of total species in the diacyl, alkenylacyl, and alkylacyl subclasses, respectively. Fatty Acids, Omega-3 15-30 solute carrier family 38 member 5 Homo sapiens 38-42 8118867-4 1994 Cultures of peritoneal macrophages from mice fed diets with n-3 fatty acids had more TNF alpha activity 24 hr after in vitro stimulation with bacterial lipopolysaccharide than did macrophages from mice fed the n-6-containing diet. Fatty Acids, Omega-3 60-75 tumor necrosis factor Mus musculus 85-94 8118867-6 1994 Experiments in which PGE2 was added exogenously indicated that the removal of TNF alpha from culture supernatant by macrophages was induced by lower concentrations of PGE2 than that associated with termination of production, and that n-3 fatty acid diets caused a selective loss in the clearance mechanism. Fatty Acids, Omega-3 234-248 tumor necrosis factor Mus musculus 78-87 8118867-7 1994 These results demonstrate a specific alteration of PGE2-mediated regulation of macrophage-produced TNF alpha by n-3 fatty acids. Fatty Acids, Omega-3 112-127 tumor necrosis factor Mus musculus 99-108 8165608-3 1993 The ability of n-3 fatty acids to modify tissue factor pathway inhibitor (TFPI) and tissue plasminogen activator inhibitor (PAI-1) was also evaluated along with fibrinogen and thrombin-antithrombin III (TAT) complexes. Fatty Acids, Omega-3 15-30 tissue factor pathway inhibitor Homo sapiens 41-72 8300367-0 1994 Dietary deficiency of N-3 fatty acids alters rhodopsin content and function in the rat retina. Fatty Acids, Omega-3 22-37 rhodopsin Rattus norvegicus 45-54 8300367-1 1994 PURPOSE: To investigate the possibility that previously demonstrated reductions in photoreceptor sensitivity to light in n-3 fatty-acid-deficient rats can be explained by alterations in rhodopsin content and/or function. Fatty Acids, Omega-3 121-135 rhodopsin Rattus norvegicus 186-195 8300367-12 1994 CONCLUSION: A reduced capacity for photon absorption by rhodopsin could play a role in lowering retinal sensitivity to light in n-3 fatty-acid-deficient rats. Fatty Acids, Omega-3 128-142 rhodopsin Rattus norvegicus 56-65 7979549-5 1994 In support of the latter response, i.e. repair, ornithine decarboxylase activity was about 20% greater in animals receiving the omega-3 fatty-acid source. Fatty Acids, Omega-3 128-146 ornithine decarboxylase, structural 1 Mus musculus 48-71 7938179-8 1994 n-3 FA reduce platelet aggregation, blood viscosity, plasma levels of fibrinogen, PF4 and beta-thromboglobulin and increase capillary flow and red cell membrane fluidity, but their long-term effects on cardiovascular mortality are largely unknown. Fatty Acids, Omega-3 0-6 fibrinogen beta chain Homo sapiens 70-80 7938179-8 1994 n-3 FA reduce platelet aggregation, blood viscosity, plasma levels of fibrinogen, PF4 and beta-thromboglobulin and increase capillary flow and red cell membrane fluidity, but their long-term effects on cardiovascular mortality are largely unknown. Fatty Acids, Omega-3 0-6 platelet factor 4 Homo sapiens 82-85 8165608-3 1993 The ability of n-3 fatty acids to modify tissue factor pathway inhibitor (TFPI) and tissue plasminogen activator inhibitor (PAI-1) was also evaluated along with fibrinogen and thrombin-antithrombin III (TAT) complexes. Fatty Acids, Omega-3 15-30 tissue factor pathway inhibitor Homo sapiens 74-78 8200011-3 1993 We evaluated the effect of the association of simvastatin 10 mg/day [an hydroxymethyl-glutaryl-CoA (HMG-CoA) reductase inhibitor] and omega-3 polyunsaturated fatty acids (n3-PUFA) in comparison with simvastatin 10 mg/day alone. Fatty Acids, Omega-3 134-169 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 72-118 8213496-3 1993 Both cholesterol and saturated fat down-regulate the LDL receptor and inhibit the removal of LDL from the plasma by the liver. Fatty Acids, Omega-3 21-34 low density lipoprotein receptor Homo sapiens 53-65 8213496-4 1993 Saturated fat down-regulates the LDL receptor, especially when cholesterol is concurrently present in the diet. Fatty Acids, Omega-3 0-13 low density lipoprotein receptor Homo sapiens 33-45 8343495-7 1993 Dietary intake of n-3 polyunsaturated fatty acids (PUFAs) showed negative associations with fibrinogen, factor VIII, and vWF (blacks and whites) and a positive association with protein C (whites only). Fatty Acids, Omega-3 18-49 von Willebrand factor Homo sapiens 121-124 8352474-0 1993 Raised dietary intake of N-3 polyunsaturated fatty acids in high sucrose-induced insulin resistance. Fatty Acids, Omega-3 25-56 insulin Homo sapiens 81-88 8415812-0 1993 Inhibition of the thermogenic and pyrogenic responses to interleukin-1 beta in the rat by dietary N-3 fatty acid supplementation. Fatty Acids, Omega-3 98-112 interleukin 1 beta Rattus norvegicus 57-75 8349510-1 1993 This study was designed to determine whether substituting menhaden fish oil (FO) for lard (LA) in a practical sow diet was a suitable method for enriching newborn pigs with omega-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 173-208 Polyunsaturated fatty acid percentage Sus scrofa 214-218 8355578-1 1993 It has recently been shown that the omega 3 fatty acid status in humans can be predicted by the concentration of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids in plasma phospholipids [Bjerve, K.S., Brubakk, A.M., Fougner, K.J., Johnsen, H., Midjthell, K., and Vik, T. (1993) Am. Fatty Acids, Omega-3 36-54 zinc finger protein 655 Homo sapiens 269-272 8461472-10 1993 Dietary omega-3 fatty acids downregulate gene expression of both PDGF-A (-66%), and PDGF-B (-70%). Fatty Acids, Omega-3 8-27 platelet derived growth factor subunit A Homo sapiens 65-71 8461472-10 1993 Dietary omega-3 fatty acids downregulate gene expression of both PDGF-A (-66%), and PDGF-B (-70%). Fatty Acids, Omega-3 8-27 platelet derived growth factor subunit B Homo sapiens 84-90 8473489-5 1993 Thus, in the primary hepatocyte, apoB degradation is not constitutive, but can be regulated by n-3 fatty acids. Fatty Acids, Omega-3 95-110 apolipoprotein B Rattus norvegicus 33-37 1459169-0 1992 Supplementation with n-3 fatty acids reduces triglycerides but increases PAI-1 in non-insulin-dependent diabetes mellitus. Fatty Acids, Omega-3 21-36 serpin family E member 1 Homo sapiens 73-78 1299268-3 1992 This change in cholesterol esterification appears to be the result of reductions in the activity of acyl-CoA:cholesterol acyltransferase (ACAT) in the endoplasmic reticulum of the macrophages incubated with the n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 211-242 sterol O-acyltransferase 2 Mus musculus 100-136 1299268-3 1992 This change in cholesterol esterification appears to be the result of reductions in the activity of acyl-CoA:cholesterol acyltransferase (ACAT) in the endoplasmic reticulum of the macrophages incubated with the n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 211-242 sterol O-acyltransferase 2 Mus musculus 138-142 1299268-6 1992 In microsomes from cells incubated with n-3 polyunsaturated fatty acids, both the Km and the Vmax of ACAT were lower than in microsomes from cells incubated with n-6 fatty acids or oleic acid. Fatty Acids, Omega-3 40-71 sterol O-acyltransferase 2 Mus musculus 101-105 1491607-5 1992 Feeding LCPE-SMA normalized plasma phospholipid levels of C20 and C22 omega 6 and omega 3 fatty acids to be similar to levels of C20 and C22 omega 6 and omega 3 fatty acids found in infants fed EBM, and significantly higher than characteristic levels for infants fed SMA-24. Fatty Acids, Omega-3 82-101 survival of motor neuron 1, telomeric Homo sapiens 13-16 1459173-1 1992 STUDY OBJECTIVE: To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis. Fatty Acids, Omega-3 73-104 pumilio RNA binding family member 3 Homo sapiens 110-114 1417409-2 1992 It has since been shown that Omega-3 fatty acids have a number of beneficial effects in the prevention of atherosclerosis in man: reduction of blood pressure, modifications of lipoprotein metabolism, modifications of haemostasis (increased bleeding time and reduced platelet aggregation), decreased plasma fibrinogen, modifications of the metabolism of arachidonic acid and its derivatives (decreased thromboxane and leukotriene synthesis, increased prostacyclin synthesis). Fatty Acids, Omega-3 29-48 fibrinogen beta chain Homo sapiens 306-316 1458789-0 1992 Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 116-147 interleukin 1 beta Homo sapiens 10-28 1458789-10 1992 We conclude that dietary supplementation with n-3 fatty acids results in significantly reduced plasma IL-1 beta levels in patients with rheumatoid arthritis. Fatty Acids, Omega-3 46-61 interleukin 1 beta Homo sapiens 102-111 1398747-0 1992 Kinetics of tumour necrosis factor and prostaglandin production by murine resident peritoneal macrophages as affected by dietary n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 129-160 tumor necrosis factor Mus musculus 12-34 1576094-3 1992 It is also known that prolonged administration of N-3 fatty acids, ticlopidine, fibrates, pentoxifylline, or alcohol lower plasma fibrinogen levels. Fatty Acids, Omega-3 50-65 fibrinogen beta chain Homo sapiens 130-140 1535648-0 1992 Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells. Fatty Acids, Omega-3 54-69 low density lipoprotein receptor Homo sapiens 85-97 1535648-0 1992 Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells. Fatty Acids, Omega-3 54-69 low density lipoprotein receptor Homo sapiens 111-115 1533162-3 1992 The supplementation of moderate amounts of n-3 fatty acids suppressed the activity of delta 6-desaturase (50%) and to a smaller extent of the delta 5-desaturase (60-70%) compared to controls. Fatty Acids, Omega-3 43-58 fatty acid desaturase 2 Rattus norvegicus 86-104 1533162-3 1992 The supplementation of moderate amounts of n-3 fatty acids suppressed the activity of delta 6-desaturase (50%) and to a smaller extent of the delta 5-desaturase (60-70%) compared to controls. Fatty Acids, Omega-3 43-58 fatty acid desaturase 1 Rattus norvegicus 142-160 1975751-0 1990 Modulation of CD4 expression on lymphoma cells transplanted to mice fed (n - 3) polyunsaturated fatty acids. Fatty Acids, Omega-3 72-107 CD4 antigen Mus musculus 14-17 1789795-4 1991 We also observed significantly lower ACAT activities in the microsomes from fibroblasts enriched with the n-3 polyunsaturated fatty acids relative to cells enriched with oleic acid or linoleic acid. Fatty Acids, Omega-3 106-137 sterol O-acyltransferase 1 Homo sapiens 37-41 1771322-3 1991 Thus, the thromboxane A2 receptor can be blocked, or its synthesis can be interrupted, by thromboxane synthetase inhibitors, by cyclooxygenase inhibitors, or by omega 3 fatty acids which are competitive inhibitors. Fatty Acids, Omega-3 161-180 thromboxane A2 receptor Homo sapiens 10-33 1832569-0 1991 Plasmatic factors of haemostasis remain essentially unchanged except for PAI activity during n-3 fatty acid intake in type I diabetes mellitus. Fatty Acids, Omega-3 93-107 serpin family E member 1 Homo sapiens 73-76 1832569-11 1991 A dietary intervention with n-3 fatty acids in these patients does not affect the plasmatic haemostatic pattern except for an increase in PAI activity. Fatty Acids, Omega-3 28-43 serpin family E member 1 Homo sapiens 138-141 1837923-3 1991 However, n-3 fatty acids in fish oils might limit oxidants via competitive inhibition of key enzymes, elevate ADPRT, and lower cancer risk. Fatty Acids, Omega-3 9-24 poly(ADP-ribose) polymerase 1 Homo sapiens 110-115 1837923-5 1991 After six weeks, ADPRT increased by 9.3 +/- 10.8% (SD) for the n-3 fatty acid group relative to the n-6 fatty acid group. Fatty Acids, Omega-3 63-77 poly(ADP-ribose) polymerase 1 Homo sapiens 17-22 1837923-8 1991 The trial suggests a "normalizing" effect of low-dose n-3 fatty acids on the ADPRT measure. Fatty Acids, Omega-3 54-69 poly(ADP-ribose) polymerase 1 Homo sapiens 77-82 2124137-7 1990 The dietary treatments did not produce significant differences in tumour incidence and mortality, but tumour size was decreased by diets supplying omega-3 fatty acids: in the EL4 mice tumour weight was markedly depressed by linseed oil, compared to soya-bean oil, whereas thymoma tumour weight was lowest in mice receiving fish oil and highest in the soya-bean oil group. Fatty Acids, Omega-3 147-166 epilepsy 4 Mus musculus 175-178 2123344-0 1990 Incorporation of marine lipids into mitochondrial membranes increases susceptibility to damage by calcium and reactive oxygen species: evidence for enhanced activation of phospholipase A2 in mitochondria enriched with n-3 fatty acids. Fatty Acids, Omega-3 218-233 phospholipase A2 group IB Rattus norvegicus 171-187 2123344-9 1990 Phospholipase A2 activity and mitochondrial damage are enhanced when mitochondrial membranes are enriched with n-3 fatty acids. Fatty Acids, Omega-3 111-126 phospholipase A2 group IB Rattus norvegicus 0-16 1578344-1 1992 Fresh lamprey (F-La) or sardine (F-Sa) oil is known to contain a large amount of n-3 polyunsaturated fatty acids such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. Fatty Acids, Omega-3 81-112 RIKEN cDNA 4932438A13 gene Mus musculus 33-37 1958693-0 1991 Tumor necrosis factor production by murine resident peritoneal macrophages is enhanced by dietary n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 98-129 tumor necrosis factor Mus musculus 0-21 1958693-2 1991 Dietary fatty acids may modulate TNF production as dietary n-3 polyunsaturated fatty acids suppress human monocyte TNF production, but enhance its secretion by murine peritoneal macrophages. Fatty Acids, Omega-3 59-90 tumor necrosis factor Homo sapiens 33-36 1958693-2 1991 Dietary fatty acids may modulate TNF production as dietary n-3 polyunsaturated fatty acids suppress human monocyte TNF production, but enhance its secretion by murine peritoneal macrophages. Fatty Acids, Omega-3 59-90 tumor necrosis factor Homo sapiens 115-118 1958693-8 1991 The results show that feeding n-3 polyunsaturated fatty acids may cause enhanced TNF production by resident peritoneal macrophages and that PGE2 is partly responsible for the effect. Fatty Acids, Omega-3 30-61 tumor necrosis factor Mus musculus 81-84 1908631-2 1991 Omega-3 fatty acids increase bleeding time; decrease platelet aggregation, blood viscosity, and fibrinogen; and increase erythrocyte deformability, thus decreasing the tendency to thrombus formation. Fatty Acids, Omega-3 0-19 fibrinogen beta chain Homo sapiens 96-106 2007907-4 1991 The (n-3) fatty acid supplementation reduced total interleukin (IL)-1 beta synthesis by 48% in young women but by 90% in older women; tumor necrosis factor was reduced by 58% in young and 70% in older women. Fatty Acids, Omega-3 4-20 interleukin 1 beta Homo sapiens 51-74 2007907-7 1991 The (n-3) fatty acid supplementation reduced IL-2 production in both groups; however, this reduction was significant only in older women. Fatty Acids, Omega-3 4-20 interleukin 2 Homo sapiens 45-49 2112114-0 1990 Interleukin-1 and tumor necrosis factor synthesis by mouse peritoneal macrophages is enhanced by dietary n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 105-136 tumor necrosis factor Mus musculus 0-39 2143055-10 1990 The n-3 oil, but not ethanol, increased the 20:3n-6/20:4n-6 ratio, indicative of an inhibition of the activity of delta-5 desaturase. Fatty Acids, Omega-3 4-11 fatty acid desaturase 1 Mus musculus 114-132 2383918-1 1990 We have studied the effect of dietary supplementation with 4 g of n-3 polyunsaturated fatty acids (n-3 PUFA) daily for 6 wk on plasma lipids, haemostasis and monocyte chemotaxis in 10 patients with untreated hypertension. Fatty Acids, Omega-3 66-97 pumilio RNA binding family member 3 Homo sapiens 103-107 2116491-15 1990 By providing competing substrates for neutrophil 5-lipoxygenase, platelets might contribute to the antiinflammatory potential of dietary n-3 fatty acids through platelet-neutrophil interaction. Fatty Acids, Omega-3 137-152 arachidonate 5-lipoxygenase Homo sapiens 49-63 33791918-0 2021 Omega-3 fatty acid protects cardiomyocytes against hypoxia-induced injury through targeting MiR-210-3p/CASP8AP2 axis. Fatty Acids, Omega-3 0-18 caspase 8 associated protein 2 Rattus norvegicus 103-111 2193579-5 1990 Reduced production of cyclooxygenase products such as PGE2 also occurs in rats fed supplemental N-3 fatty acids, and this was associated with a decreased anorexic response to IL-1. Fatty Acids, Omega-3 96-111 interleukin 1 beta Homo sapiens 175-179 2193579-10 1990 The ability of N-3 fatty acids to reduce IL-1 synthesis appears to be via the lipoxygenase pathway. Fatty Acids, Omega-3 15-30 interleukin 1 beta Homo sapiens 41-45 2193579-11 1990 Therefore, N-3 fatty acids may be beneficial to patients with anorexia, since such supplements would decrease both the anorexic response to IL-1 via reduced cyclooxygenase metabolites and the production of IL-1, via altered lipoxygenase metabolites. Fatty Acids, Omega-3 11-26 interleukin 1 beta Homo sapiens 140-144 2193579-11 1990 Therefore, N-3 fatty acids may be beneficial to patients with anorexia, since such supplements would decrease both the anorexic response to IL-1 via reduced cyclooxygenase metabolites and the production of IL-1, via altered lipoxygenase metabolites. Fatty Acids, Omega-3 11-26 interleukin 1 beta Homo sapiens 206-236 33791918-13 2021 We provide strong evidence showing that Omega-3 fatty acids can attenuate apoptosis in cardiomyocyte under hypoxic conditions via the up-regulation of miR-210-3p and targeting CASP8AP2 signaling pathway. Fatty Acids, Omega-3 40-59 caspase 8 associated protein 2 Rattus norvegicus 176-184 33810216-0 2021 Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1alpha via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model. Fatty Acids, Omega-3 0-19 sirtuin 1 Rattus norvegicus 31-38 33801688-8 2021 Compared to the omega-6 FA group, the supplementation with omega-3 FA for 12 weeks significantly reduced plasma TXB (p = 0.024) and increased BDNF (p = 0.011) levels. Fatty Acids, Omega-3 59-69 brain derived neurotrophic factor Homo sapiens 142-146 33810216-0 2021 Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1alpha via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model. Fatty Acids, Omega-3 0-19 PPARG coactivator 1 alpha Rattus norvegicus 49-59 33810216-0 2021 Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1alpha via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model. Fatty Acids, Omega-3 0-19 nuclear respiratory factor 1 Rattus norvegicus 90-94 33801889-9 2021 Conclusions: n-3 PUFAs inhibit NF-kappaB/COX-2 induced production of pro-inflammatory cytokines and inhibit cell apoptosis mainly by extrinsic pathway in rats with MTX-induced intestinal damage. Fatty Acids, Omega-3 13-22 cytochrome c oxidase II, mitochondrial Rattus norvegicus 41-46 33760818-10 2021 This locus is significantly associated with higher GJB2 expression of connexin 26 in adipose tissue; connexin activity is known to change upon exposure to omega-3 fatty acids. Fatty Acids, Omega-3 155-174 gap junction protein beta 2 Homo sapiens 51-55 33760818-10 2021 This locus is significantly associated with higher GJB2 expression of connexin 26 in adipose tissue; connexin activity is known to change upon exposure to omega-3 fatty acids. Fatty Acids, Omega-3 155-174 gap junction protein beta 2 Homo sapiens 70-81 27367537-0 2016 n-3 Fatty acids modulate the mRNA expression of the Nlrp3 inflammasome and Mtor in the liver of rats fed with high-fat or high-fat/fructose diets. Fatty Acids, Omega-3 0-15 NLR family, pyrin domain containing 3 Rattus norvegicus 52-57 27367537-0 2016 n-3 Fatty acids modulate the mRNA expression of the Nlrp3 inflammasome and Mtor in the liver of rats fed with high-fat or high-fat/fructose diets. Fatty Acids, Omega-3 0-15 mechanistic target of rapamycin kinase Rattus norvegicus 75-79 27367537-1 2016 CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. Fatty Acids, Omega-3 32-63 CREB regulated transcription coactivator 1 Mus musculus 88-94 27367537-1 2016 CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. Fatty Acids, Omega-3 32-63 NLR family, pyrin domain containing 3 Rattus norvegicus 144-149 27367537-1 2016 CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. Fatty Acids, Omega-3 65-74 CREB regulated transcription coactivator 1 Mus musculus 88-94 27367537-1 2016 CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. Fatty Acids, Omega-3 65-74 NLR family, pyrin domain containing 3 Rattus norvegicus 144-149 34801691-8 2022 CONCLUSION: Lifetime supply of n-3 PUFA ameliorated bone loss induced by chronic stress by regulating hypothalamic-pituitary-adrenal axis activity and serotonin-CREB signaling. Fatty Acids, Omega-3 31-39 cAMP responsive element binding protein 1 Rattus norvegicus 161-165 34895805-7 2022 Dietetic (omega-3 fatty acids, stanols, polyphenols, lycopene) and non-dietetic (fibrates, statins, and antisense oligonucleotides) therapies have shown promising results to regulate Apo-CIII and triglyceride levels. Fatty Acids, Omega-3 10-29 apolipoprotein C3 Homo sapiens 183-191 34922604-2 2021 Omega-3 (omega3) fatty acids can modulate the downstream signaling of Toll-like receptor (TLR) and tumor necrosis factor-alpha receptor (TNFalpha) through GPR120, a G-protein-coupled receptor, a mechanism not yet elucidated in humans. Fatty Acids, Omega-3 0-28 TNF receptor superfamily member 1A Homo sapiens 99-135 34896909-4 2022 The objective of this study was to investigate the effect of omega3 fatty acid deficiency in the perinatal period on maternal behavior and the oxytocin concentration and fatty acid composition in brain tissue. Fatty Acids, Omega-3 61-78 oxytocin/neurophysin I prepropeptide Homo sapiens 143-151 34896909-5 2022 MATERIALS AND METHODS: Virgin female C57BL/6 J mice fed a omega3 fatty acid-deficient (omega3-Def) or adequate (omega3-Adq) diet were mated for use in this study. Fatty Acids, Omega-3 87-93 UTP25 small subunit processome component Mus musculus 94-97 34933001-0 2022 Omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of OPA1-related autosomal dominant optic atrophy. Fatty Acids, Omega-3 0-19 OPA1, mitochondrial dynamin like GTPase Mus musculus 133-137 34933001-1 2022 The purpose of this study was to evaluate the neuroprotective effects of omega-3 polyunsaturated fatty acid (omega3-PUFA) supplementation in a mouse model of OPA1-associated autosomal dominant optic atrophy (ADOA). Fatty Acids, Omega-3 73-107 OPA1, mitochondrial dynamin like GTPase Mus musculus 158-162 34933001-1 2022 The purpose of this study was to evaluate the neuroprotective effects of omega-3 polyunsaturated fatty acid (omega3-PUFA) supplementation in a mouse model of OPA1-associated autosomal dominant optic atrophy (ADOA). Fatty Acids, Omega-3 109-120 OPA1, mitochondrial dynamin like GTPase Mus musculus 158-162 34922604-2 2021 Omega-3 (omega3) fatty acids can modulate the downstream signaling of Toll-like receptor (TLR) and tumor necrosis factor-alpha receptor (TNFalpha) through GPR120, a G-protein-coupled receptor, a mechanism not yet elucidated in humans. Fatty Acids, Omega-3 0-28 tumor necrosis factor Homo sapiens 137-145 34922604-2 2021 Omega-3 (omega3) fatty acids can modulate the downstream signaling of Toll-like receptor (TLR) and tumor necrosis factor-alpha receptor (TNFalpha) through GPR120, a G-protein-coupled receptor, a mechanism not yet elucidated in humans. Fatty Acids, Omega-3 0-28 free fatty acid receptor 4 Homo sapiens 155-161 34922604-3 2021 This work aims to investigate if the omega3 supplementation, at a feasible level below the previously recommended level in the literature, is enough to disrupt the inflammation and endoplasmic reticulum stress (ER-stress), and also if in acute treatment (3 h) omega3 can activate the GPR120 in peripheral blood mononuclear cells (PBMC) and leukocytes from overweight non-alcoholic fatty liver disease (NAFLD) participants. Fatty Acids, Omega-3 37-43 free fatty acid receptor 4 Homo sapiens 284-290 34922604-3 2021 This work aims to investigate if the omega3 supplementation, at a feasible level below the previously recommended level in the literature, is enough to disrupt the inflammation and endoplasmic reticulum stress (ER-stress), and also if in acute treatment (3 h) omega3 can activate the GPR120 in peripheral blood mononuclear cells (PBMC) and leukocytes from overweight non-alcoholic fatty liver disease (NAFLD) participants. Fatty Acids, Omega-3 260-266 free fatty acid receptor 4 Homo sapiens 284-290 34455435-3 2021 Long-Term Outcomes Study to Assess Statin Residual Risk with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridaemia (STRENGTH), can be explained by differences in the effect of active and comparator oils on lipid traits and C-reactive protein. Fatty Acids, Omega-3 61-68 C-reactive protein Homo sapiens 241-259 34943094-0 2021 The Impact of Medium Chain and Polyunsaturated omega-3-Fatty Acids on Amyloid-beta Deposition, Oxidative Stress and Metabolic Dysfunction Associated with Alzheimer"s Disease. Fatty Acids, Omega-3 47-66 amyloid beta precursor protein Homo sapiens 70-82 34943094-6 2021 This review summarizes the current knowledge about the molecular mechanisms by which MCFAs and omega-3-PUFAs reduce the cerebral Abeta deposition, improve brain energy metabolism, and lessen oxidative stress levels. Fatty Acids, Omega-3 95-108 amyloid beta precursor protein Homo sapiens 129-134 34742136-1 2021 BACKGROUND & AIMS: Circulating microvesicles (cMV) are both effectors and biomarkers of cardiovascular disease (CVD), and the effects of omega 3 polyunsaturated fatty acids (n3 PUFA) in MV shedding are not yet well known. Fatty Acids, Omega-3 137-172 pumilio RNA binding family member 3 Homo sapiens 177-181 34945600-1 2021 Gluten-free pasta enriched with fish can support a nutritive and suitable option for people with celiac disease that allows achieving the benefits of fish consumption, especially the consumption of Omega-3 fatty acids; however, this requires that the pasta has adequate technological and sensory properties. Fatty Acids, Omega-3 198-217 solute carrier family 45 member 1 Homo sapiens 12-17 34812629-1 2021 Numerous health benefits are associated with omega-3 polyunsaturated fatty acids (n-3 PUFA) consumed in fish oils. Fatty Acids, Omega-3 45-80 pumilio RNA binding family member 3 Homo sapiens 86-90 34959363-5 2021 N-3 polyunsaturated fatty acids (n-3 PUFA) have a protective effect, affect beta-cell preservation, and increase endogenous insulin production. Fatty Acids, Omega-3 0-31 pumilio RNA binding family member 3 Homo sapiens 37-41 34959363-5 2021 N-3 polyunsaturated fatty acids (n-3 PUFA) have a protective effect, affect beta-cell preservation, and increase endogenous insulin production. Fatty Acids, Omega-3 0-31 insulin Homo sapiens 124-131 34857226-1 2021 BACKGROUND & AIMS: The skeletal muscle anabolic effects of n-3 polyunsaturated fatty acids (n-3 PUFA) appear favoured towards women; a property that could be exploited in older women who typically exhibit poor muscle growth responses to resistance exercise training (RET). Fatty Acids, Omega-3 59-90 pumilio RNA binding family member 3 Homo sapiens 96-100 34849527-9 2021 PEMT is dramatically induced in response to estrogen, producing not only a PC molecule and source of choline for the brain but also a key source of the long-chain omega-3 fatty acid, DHA. Fatty Acids, Omega-3 163-181 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-4 34516692-9 2021 Reducing effects of omega-3 supplementation compared to control group were also observed in the levels of ESR and CRP after treatment (p<0.001 for CRP and p=0.02 for ESR). Fatty Acids, Omega-3 20-27 C-reactive protein Homo sapiens 114-117 34516692-9 2021 Reducing effects of omega-3 supplementation compared to control group were also observed in the levels of ESR and CRP after treatment (p<0.001 for CRP and p=0.02 for ESR). Fatty Acids, Omega-3 20-27 C-reactive protein Homo sapiens 147-150 34836347-0 2021 N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the Fat-1 Mouse Model. Fatty Acids, Omega-3 0-31 FAT atypical cadherin 1 Mus musculus 108-113 34884454-2 2021 Interestingly, these lower levels of PKCzeta were increased/normalized by supplementing women during pregnancy with n-3 polyunsaturated fatty acids. Fatty Acids, Omega-3 116-147 protein kinase C zeta Homo sapiens 37-44 34813379-1 2022 It is well established that diets containing an increased omega-6 polyunsaturated fatty acid (n-6 PUFA) to omega-3 polyunsaturated fatty acid (n-3 PUFA) ratios are linked to inflammation and chronic diseases such as nonalcoholic fatty liver disease (NAFLD). Fatty Acids, Omega-3 107-114 pumilio RNA binding family member 3 Homo sapiens 98-102 34813379-1 2022 It is well established that diets containing an increased omega-6 polyunsaturated fatty acid (n-6 PUFA) to omega-3 polyunsaturated fatty acid (n-3 PUFA) ratios are linked to inflammation and chronic diseases such as nonalcoholic fatty liver disease (NAFLD). Fatty Acids, Omega-3 107-114 pumilio RNA binding family member 3 Homo sapiens 147-151 34836347-4 2021 Fat-1 mice, capable of synthesizing n-3 PUFA endogenously from n-6 PUFA, and their wild-type (WT) counterparts, were subjected to a mild low-impact WDI on the closed cranium, and recovery was evaluated using the neurological severity score (NSS) to assess the motor and neurobehavioral outcomes. Fatty Acids, Omega-3 36-44 FAT atypical cadherin 1 Mus musculus 0-5 34549475-0 2021 Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice. Fatty Acids, Omega-3 17-36 apolipoprotein E Homo sapiens 77-82 34706241-4 2021 Using fat-1 transgenic mice, which convert n-6 fatty acids to n-3 fatty acids, we find that reduction of the n-6/n-3 ratio decreases the phagocytic infiltrate. Fatty Acids, Omega-3 62-77 FAT atypical cadherin 1 Mus musculus 6-11 34132788-10 2021 CONCLUSIONS: n-3 PUFAs consumption alters IgG N-glycan traits and IL-10 in healthy individuals, and total plasma protein N-glycan traits in CV patients, by shifting them toward less inflammatory N-glycosylation profile. Fatty Acids, Omega-3 13-22 interleukin 10 Homo sapiens 66-71 34414450-0 2021 Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity. Fatty Acids, Omega-3 0-35 interleukin 11 Mus musculus 44-49 34414450-0 2021 Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity. Fatty Acids, Omega-3 0-35 signal transducer and activator of transcription 3 Mus musculus 50-55 34414450-1 2021 Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert a negative effect on IL-6 production in several liver disorders, including cirrhosis, acute liver failure and fatty liver disease. Fatty Acids, Omega-3 0-35 interleukin 6 Mus musculus 75-79 34414450-1 2021 Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert a negative effect on IL-6 production in several liver disorders, including cirrhosis, acute liver failure and fatty liver disease. Fatty Acids, Omega-3 37-46 interleukin 6 Mus musculus 75-79 34414450-9 2021 The results revealed that both endogenous and exogenous n-3 PUFAs significantly aggravated APAP-induced liver damage via the downregulation of STAT3 signaling. Fatty Acids, Omega-3 56-65 signal transducer and activator of transcription 3 Mus musculus 143-148 34414450-12 2021 It was concluded that n-3 PUFAs inhibit IL-11 production and further STAT3 activation in hepatocytes during APAP-induced liver injury. Fatty Acids, Omega-3 22-31 interleukin 11 Mus musculus 40-45 34414450-12 2021 It was concluded that n-3 PUFAs inhibit IL-11 production and further STAT3 activation in hepatocytes during APAP-induced liver injury. Fatty Acids, Omega-3 22-31 signal transducer and activator of transcription 3 Mus musculus 69-74 34246922-9 2021 Furthermore, in cellular systems, n-3 PUFAs favored the synthesis of CoQ10 over CoQ9, thus altering the ratio between CoQ isoforms through a mechanism that involved downregulation of farnesyl diphosphate synthase activity. Fatty Acids, Omega-3 34-43 farnesyl diphosphate synthase Homo sapiens 183-212 34638763-6 2021 However, n-3 polyunsaturated fatty acids (PUFA) were decreased in the category with the highest C-peptide concentration (n-3 PUFA: CI -35.82--6.28, p < 0.006) and in the lowest ISHOMA category (n-3 PUFA: CI -36.48--5.61, p < 0.008). Fatty Acids, Omega-3 9-40 insulin Homo sapiens 96-105 34760272-9 2021 Conclusion: The current meta-analysis indicated an efficacy of omega 3 in reducing CK, LDH, and Mb serum concentration among healthy individuals, overall and in subgroups analysis. Fatty Acids, Omega-3 63-70 cytidine/uridine monophosphate kinase 1 Homo sapiens 83-85 34378609-5 2021 The aim of this study was to evaluate the effect of consumption of chia seeds on the lipid profile, triglycerides, and serum omega-3 fatty acids in adults. Fatty Acids, Omega-3 125-144 chitinase acidic Homo sapiens 67-71 34298398-0 2021 omega-3 fatty acid alleviates virus-induced myocardial injury by regulating TLR4 and TLR3 expression. Fatty Acids, Omega-3 0-18 toll like receptor 4 Homo sapiens 76-80 34298398-0 2021 omega-3 fatty acid alleviates virus-induced myocardial injury by regulating TLR4 and TLR3 expression. Fatty Acids, Omega-3 0-18 toll like receptor 3 Homo sapiens 85-89 34298398-6 2021 omega-3 fatty acid therapy in patients with virus-induced myocardial injury significantly regulates the expression of TLR3 and TLR4 and their downstream signal protein, increases antioxidant expression, reduces the secretion of inflammatory factors, alleviates myocardial injury, and improves cardiac function. Fatty Acids, Omega-3 0-18 toll like receptor 3 Homo sapiens 118-122 34298398-6 2021 omega-3 fatty acid therapy in patients with virus-induced myocardial injury significantly regulates the expression of TLR3 and TLR4 and their downstream signal protein, increases antioxidant expression, reduces the secretion of inflammatory factors, alleviates myocardial injury, and improves cardiac function. Fatty Acids, Omega-3 0-18 toll like receptor 4 Homo sapiens 127-131 34488585-5 2021 These omega-3 fatty acids target therapy-induced central players NF-kappaB, and ROS to prevent drug-associated metastasis, therapy resistance, and off-target toxicities. Fatty Acids, Omega-3 6-25 nuclear factor kappa B subunit 1 Homo sapiens 65-74 34604280-0 2021 APOE Genotype Modifies the Plasma Oxylipin Response to Omega-3 Polyunsaturated Fatty Acid Supplementation in Healthy Individuals. Fatty Acids, Omega-3 55-89 apolipoprotein E Homo sapiens 0-4 34578973-2 2021 Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation could diminish the adverse effect of weight loss on bone health. Fatty Acids, Omega-3 0-34 pumilio RNA binding family member 3 Homo sapiens 40-44 34144071-11 2021 CONCLUSIONS: Intensive nutritional intervention with Vitamin D and Omega-3 PUFA supplementation may benefit men on active surveillance for prostate cancer and further studies are warranted. Fatty Acids, Omega-3 67-74 pumilio RNA binding family member 3 Homo sapiens 75-79 34515971-2 2021 Several reports in the clinical literature show that long chain n-3 polyunsaturated fatty acid (LC n-3 PUFA) ingestion promotes skeletal muscle anabolism and strength in untrained older persons. Fatty Acids, Omega-3 64-94 pumilio RNA binding family member 3 Homo sapiens 103-107 34458651-21 2021 Highlights: Omega3 fatty acids as a ligand of metabolic-related genes, have a role in energy expenditure.Omega3 supplements effect on PPARgamma and UCP2 mRNA expression as regulators of energy metabolismOmega3 supplements increased REE.Omega-3 supplementation could change the changes in body composition.For athletes, omega-3 simultaneously decreased fat mass and increased fat-mass.HDL-C increased after short-term supplementation with omega-3.Increased intake of omega-3, caused increased intake of energy and protein. Fatty Acids, Omega-3 12-30 uncoupling protein 2 Homo sapiens 148-152 34531743-0 2021 Fat-1 Transgenic Mice With Augmented n3-Polyunsaturated Fatty Acids Are Protected From Liver Injury Caused by Acute-On-Chronic Ethanol Administration. Fatty Acids, Omega-3 37-67 FAT atypical cadherin 1 Mus musculus 0-5 34378390-0 2021 Using Fecal DNA Metabarcoding to Investigate Foraging Reveals the Effects of Specific Herbage on the Improved n-3 Fatty Acid (PUFA) Composition in the Longissimus Dorsi Muscle of Grazing Tan Sheep. Fatty Acids, Omega-3 110-124 PUFA Ovis aries 126-130 34458651-0 2021 The Effect of omega3 Fatty Acids Supplementation on Levels of PPARgamma and UCP2 Genes Expression, Serum Level of UCP2 Protein, Metabolic Status, and Appetite in Elite male Athletes: Protocol for a Randomized Control Trial. Fatty Acids, Omega-3 14-32 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 34458651-0 2021 The Effect of omega3 Fatty Acids Supplementation on Levels of PPARgamma and UCP2 Genes Expression, Serum Level of UCP2 Protein, Metabolic Status, and Appetite in Elite male Athletes: Protocol for a Randomized Control Trial. Fatty Acids, Omega-3 14-32 uncoupling protein 2 Homo sapiens 76-80 34369571-3 2021 Results showed that n-3 PUFAs could abate LPS-induced secretions of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta in MAC-T cells through the nuclear transcription factor kappa B (NF-kappaB) signal pathway. Fatty Acids, Omega-3 20-29 tumor necrosis factor Bos taurus 68-95 34369571-3 2021 Results showed that n-3 PUFAs could abate LPS-induced secretions of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta in MAC-T cells through the nuclear transcription factor kappa B (NF-kappaB) signal pathway. Fatty Acids, Omega-3 20-29 interferon beta-2 Bos taurus 97-115 34369571-3 2021 Results showed that n-3 PUFAs could abate LPS-induced secretions of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta in MAC-T cells through the nuclear transcription factor kappa B (NF-kappaB) signal pathway. Fatty Acids, Omega-3 20-29 interleukin 1 alpha Bos taurus 120-128 34369571-3 2021 Results showed that n-3 PUFAs could abate LPS-induced secretions of tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta in MAC-T cells through the nuclear transcription factor kappa B (NF-kappaB) signal pathway. Fatty Acids, Omega-3 20-29 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 194-203 34369571-6 2021 Collectively, both in vitro and in vivo experiments revealed that n-3 PUFAs have a positive effect on LPS-induced inflammatory response, which was possibly mediated by the NF-kappaB signaling pathway and the intestinal microbiota. Fatty Acids, Omega-3 66-75 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 172-181 34458651-3 2021 The objective of the present study is to determine the effects of omega3 fatty acids on the gene expression of PPARgamma and UCP2, levels of blood lipid profile, fat mass, and fat-free mass, and appetite. Fatty Acids, Omega-3 66-84 peroxisome proliferator activated receptor gamma Homo sapiens 111-120 34458651-3 2021 The objective of the present study is to determine the effects of omega3 fatty acids on the gene expression of PPARgamma and UCP2, levels of blood lipid profile, fat mass, and fat-free mass, and appetite. Fatty Acids, Omega-3 66-84 uncoupling protein 2 Homo sapiens 125-129 34458651-21 2021 Highlights: Omega3 fatty acids as a ligand of metabolic-related genes, have a role in energy expenditure.Omega3 supplements effect on PPARgamma and UCP2 mRNA expression as regulators of energy metabolismOmega3 supplements increased REE.Omega-3 supplementation could change the changes in body composition.For athletes, omega-3 simultaneously decreased fat mass and increased fat-mass.HDL-C increased after short-term supplementation with omega-3.Increased intake of omega-3, caused increased intake of energy and protein. Fatty Acids, Omega-3 105-111 peroxisome proliferator activated receptor gamma Homo sapiens 134-143 34458651-18 2021 This study could result in the effects of omega-3 fatty acids on PPARgamma, and UCP2 expressions, blood lipid profiles and body composition. Fatty Acids, Omega-3 42-61 peroxisome proliferator activated receptor gamma Homo sapiens 65-74 34458651-18 2021 This study could result in the effects of omega-3 fatty acids on PPARgamma, and UCP2 expressions, blood lipid profiles and body composition. Fatty Acids, Omega-3 42-61 uncoupling protein 2 Homo sapiens 80-84 34458651-21 2021 Highlights: Omega3 fatty acids as a ligand of metabolic-related genes, have a role in energy expenditure.Omega3 supplements effect on PPARgamma and UCP2 mRNA expression as regulators of energy metabolismOmega3 supplements increased REE.Omega-3 supplementation could change the changes in body composition.For athletes, omega-3 simultaneously decreased fat mass and increased fat-mass.HDL-C increased after short-term supplementation with omega-3.Increased intake of omega-3, caused increased intake of energy and protein. Fatty Acids, Omega-3 105-111 uncoupling protein 2 Homo sapiens 148-152 34458651-21 2021 Highlights: Omega3 fatty acids as a ligand of metabolic-related genes, have a role in energy expenditure.Omega3 supplements effect on PPARgamma and UCP2 mRNA expression as regulators of energy metabolismOmega3 supplements increased REE.Omega-3 supplementation could change the changes in body composition.For athletes, omega-3 simultaneously decreased fat mass and increased fat-mass.HDL-C increased after short-term supplementation with omega-3.Increased intake of omega-3, caused increased intake of energy and protein. Fatty Acids, Omega-3 319-326 peroxisome proliferator activated receptor gamma Homo sapiens 134-143 34458651-21 2021 Highlights: Omega3 fatty acids as a ligand of metabolic-related genes, have a role in energy expenditure.Omega3 supplements effect on PPARgamma and UCP2 mRNA expression as regulators of energy metabolismOmega3 supplements increased REE.Omega-3 supplementation could change the changes in body composition.For athletes, omega-3 simultaneously decreased fat mass and increased fat-mass.HDL-C increased after short-term supplementation with omega-3.Increased intake of omega-3, caused increased intake of energy and protein. Fatty Acids, Omega-3 319-326 uncoupling protein 2 Homo sapiens 148-152 34458651-21 2021 Highlights: Omega3 fatty acids as a ligand of metabolic-related genes, have a role in energy expenditure.Omega3 supplements effect on PPARgamma and UCP2 mRNA expression as regulators of energy metabolismOmega3 supplements increased REE.Omega-3 supplementation could change the changes in body composition.For athletes, omega-3 simultaneously decreased fat mass and increased fat-mass.HDL-C increased after short-term supplementation with omega-3.Increased intake of omega-3, caused increased intake of energy and protein. Fatty Acids, Omega-3 438-445 peroxisome proliferator activated receptor gamma Homo sapiens 134-143 34458651-21 2021 Highlights: Omega3 fatty acids as a ligand of metabolic-related genes, have a role in energy expenditure.Omega3 supplements effect on PPARgamma and UCP2 mRNA expression as regulators of energy metabolismOmega3 supplements increased REE.Omega-3 supplementation could change the changes in body composition.For athletes, omega-3 simultaneously decreased fat mass and increased fat-mass.HDL-C increased after short-term supplementation with omega-3.Increased intake of omega-3, caused increased intake of energy and protein. Fatty Acids, Omega-3 438-445 uncoupling protein 2 Homo sapiens 148-152 34353392-0 2022 Long-term vitamin D and high-dose n-3 fatty acids" supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD - Expression of concern. Fatty Acids, Omega-3 34-49 choline dehydrogenase Homo sapiens 140-143 34439504-9 2021 A supplementation with omega-3 FA, but not with omega-6 FA, decreased 8-IsoP-U, AOPP, NT levels and increased TEAC and SOD activity. Fatty Acids, Omega-3 23-33 superoxide dismutase 1 Homo sapiens 119-122 34421366-10 2021 Omega-3 partially prevented the damage caused by the HFD to the expression of alpha7nAChR in the bone marrow and hypothalamus, decreased the inflammatory markers, and reduced susceptibility to sepsis-induced death. Fatty Acids, Omega-3 0-7 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 78-89 34286397-0 2022 Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patients. Fatty Acids, Omega-3 0-19 alpha 2-HS glycoprotein Homo sapiens 68-76 34216224-5 2021 The anti-inflammatory role of resolvin D1 (RvD1), a pro-resolving mediator derived from omega-3 fatty acids, has demonstrated that the NF-kappaB/NLRP3 inflammasome pathway in different tissues is attenuated after treatment with RvD1. Fatty Acids, Omega-3 88-107 nuclear factor kappa B subunit 1 Homo sapiens 135-144 34216224-5 2021 The anti-inflammatory role of resolvin D1 (RvD1), a pro-resolving mediator derived from omega-3 fatty acids, has demonstrated that the NF-kappaB/NLRP3 inflammasome pathway in different tissues is attenuated after treatment with RvD1. Fatty Acids, Omega-3 88-107 NLR family pyrin domain containing 3 Homo sapiens 145-150 34246927-0 2021 Endogenous omega-3 fatty acids in Fat-1 mice attenuated depression-like behaviors, spatial memory impairment and relevant changes induced by olfactory bulbectomy. Fatty Acids, Omega-3 11-30 FAT atypical cadherin 1 Mus musculus 34-39 34246927-4 2021 This study used Fat-1 mice, which can convert n-6 to n-3 PUFAs in the brain, to study the effect of n-3 PUFAs on OB-induced behaviors and related changes. Fatty Acids, Omega-3 53-62 FAT atypical cadherin 1 Mus musculus 16-21 34286397-0 2022 Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patients. Fatty Acids, Omega-3 0-19 TNF receptor superfamily member 11b Homo sapiens 81-96 34286397-2 2022 This study aimed at investigating the effect of omega-3 fatty acids on the vascular calcification biomarkers fetuin-A and osteoprotegerin (OPG) in patients with chronic renal failure who are undergoing hemodialysis. Fatty Acids, Omega-3 48-67 alpha 2-HS glycoprotein Homo sapiens 109-117 34286397-2 2022 This study aimed at investigating the effect of omega-3 fatty acids on the vascular calcification biomarkers fetuin-A and osteoprotegerin (OPG) in patients with chronic renal failure who are undergoing hemodialysis. Fatty Acids, Omega-3 48-67 TNF receptor superfamily member 11b Homo sapiens 122-137 34286397-2 2022 This study aimed at investigating the effect of omega-3 fatty acids on the vascular calcification biomarkers fetuin-A and osteoprotegerin (OPG) in patients with chronic renal failure who are undergoing hemodialysis. Fatty Acids, Omega-3 48-67 TNF receptor superfamily member 11b Homo sapiens 139-142 34286397-7 2022 Our study concluded that omega-3 may have a clinically beneficial effect in decreasing cardiovascular events by increasing the levels of the protective vascular calcification inhibitors fetuin-A and osteoprotegerin in chronic renal failure patients who are undergoing hemodialysis. Fatty Acids, Omega-3 25-32 alpha 2-HS glycoprotein Homo sapiens 186-194 34286397-7 2022 Our study concluded that omega-3 may have a clinically beneficial effect in decreasing cardiovascular events by increasing the levels of the protective vascular calcification inhibitors fetuin-A and osteoprotegerin in chronic renal failure patients who are undergoing hemodialysis. Fatty Acids, Omega-3 25-32 TNF receptor superfamily member 11b Homo sapiens 199-214 34371972-1 2021 Resistance training (RT) and n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation have emerged as strategies to improve muscle function in older adults. Fatty Acids, Omega-3 29-60 pumilio RNA binding family member 3 Homo sapiens 66-70 34214231-1 2022 OBJECTIVE: To evaluate the effects of fish oil (FO), a source of the omega-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on emotion-generated corticolimbic functional connectivity in depressed youth at high risk for developing bipolar I disorder. Fatty Acids, Omega-3 69-104 pumilio RNA binding family member 3 Homo sapiens 110-114 34371852-1 2021 Previous epidemiological studies have investigated the association of fish and marine n-3 polyunsaturated fatty acids (n-3 PUFA) consumption with cardiovascular disease (CVD) mortality risk. Fatty Acids, Omega-3 86-117 pumilio RNA binding family member 3 Homo sapiens 123-127 34327207-13 2021 Red blood cell omega-3 fatty acid content increased from PRE to POST in the MV group (p < 0.001) and placebo group (p < 0.05), although POST values were greater in the MV group (p < 0.001). Fatty Acids, Omega-3 15-33 solute carrier family 35 member G1 Homo sapiens 64-68 34405148-1 2021 Introduction: Collagen and omega-3 fatty acids (FAs) are suggested to have anti-inflammatory, anti-oxidant, and insulin-sensitizing properties. Fatty Acids, Omega-3 27-46 insulin Homo sapiens 112-119 34405148-5 2021 Results: Based on post-hoc analyses, hs-CRP levels were significantly lower in the collagen (p=0.026) and collagen+omega-3 (p=0.044) groups compared to the control group, at week three. Fatty Acids, Omega-3 115-122 C-reactive protein Homo sapiens 40-43 34183020-4 2021 The use of omega-3 fatty acid supplements was reported in 856 out of 1002 recreational athletes, and the association between supplement use and the exercise-induced CRP response was assessed. Fatty Acids, Omega-3 11-29 C-reactive protein Homo sapiens 165-168 34356043-5 2021 Importantly, gas chromatography analysis revealed a significantly increased n-3 polyunsaturated fatty acid (PUFA) level in these genetically modified pigs, which led to a significant decrease of the n-6 PUFA/n-3 PUFA ratio from 6.982 to 3.122 (*** p < 0.001). Fatty Acids, Omega-3 76-106 Polyunsaturated fatty acid percentage Sus scrofa 108-112 34356043-5 2021 Importantly, gas chromatography analysis revealed a significantly increased n-3 polyunsaturated fatty acid (PUFA) level in these genetically modified pigs, which led to a significant decrease of the n-6 PUFA/n-3 PUFA ratio from 6.982 to 3.122 (*** p < 0.001). Fatty Acids, Omega-3 76-106 Polyunsaturated fatty acid percentage Sus scrofa 203-207 34356043-5 2021 Importantly, gas chromatography analysis revealed a significantly increased n-3 polyunsaturated fatty acid (PUFA) level in these genetically modified pigs, which led to a significant decrease of the n-6 PUFA/n-3 PUFA ratio from 6.982 to 3.122 (*** p < 0.001). Fatty Acids, Omega-3 76-106 Polyunsaturated fatty acid percentage Sus scrofa 212-216 34208905-0 2021 Simultaneous Pretreatment of Aspirin and Omega-3 Fatty Acid Attenuates Nuclear Factor-kappaB Activation in a Murine Model with Ventilator-Induced Lung Injury. Fatty Acids, Omega-3 41-59 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 71-92 34208905-4 2021 We compared the lung inflammation after the sequential administration of lipopolysaccharides and mechanical ventilation between the pretreated simultaneous enteral aspirin and omega-3 fatty acid group and the non-pretreatment group, by quantifying NF-kappaB activation using an in vivo imaging system to detect bioluminescence signals. Fatty Acids, Omega-3 176-194 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 248-257 34208905-6 2021 Compared to the non-pretreated group, the pretreatment group with simultaneous enteral aspirin and omega-3 fatty acid showed reduced expression of the pro-inflammatory cytokine, tumor necrosis factor-alpha, in bronchoalveolar lavage fluid (p = 0.038). Fatty Acids, Omega-3 99-117 tumor necrosis factor Mus musculus 178-205 34183020-7 2021 Regular users of omega-3 fatty acid supplements had significantly lower basal and exercise-induced CRP levels as compared to non-users (n = 348, p < 0.001). Fatty Acids, Omega-3 17-35 C-reactive protein Homo sapiens 99-102 34183020-11 2021 CONCLUSION: Basal CRP levels were reduced, and the exercise-induced CRP response was attenuated in healthy recreational cyclists who used omega-3 fatty acid supplements regularly. Fatty Acids, Omega-3 138-156 C-reactive protein Homo sapiens 18-21 34183020-11 2021 CONCLUSION: Basal CRP levels were reduced, and the exercise-induced CRP response was attenuated in healthy recreational cyclists who used omega-3 fatty acid supplements regularly. Fatty Acids, Omega-3 138-156 C-reactive protein Homo sapiens 68-71 34201625-5 2021 Here, we discuss the role of a FADS gene-by-dietary PUFA interaction model that takes into consideration dietary exposure, including the intake of LA and ALA, n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in determining the efficacy of n-3 PUFA supplementation. Fatty Acids, Omega-3 159-168 stearoyl-CoA desaturase Homo sapiens 31-35 34091118-1 2021 Fish contain many important nutrients and are primarily known for high n-3 polyunsaturated fatty acids (n-3 PUFA) content. Fatty Acids, Omega-3 71-102 pumilio RNA binding family member 3 Homo sapiens 108-112 34207160-3 2021 Thus, the modification of the FA profile-especially an increase in the concentration of polyunsaturated FAs and n-3 FAs in bovine milk fat-is desirable. Fatty Acids, Omega-3 112-119 FAT atypical cadherin 1 Bos taurus 135-138 34150829-0 2021 Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-Tau, GFAP, and UCH-L1 in Experimental Traumatic Brain Injury. Fatty Acids, Omega-3 0-19 glial fibrillary acidic protein Rattus norvegicus 57-61 34150829-0 2021 Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-Tau, GFAP, and UCH-L1 in Experimental Traumatic Brain Injury. Fatty Acids, Omega-3 0-19 ubiquitin C-terminal hydrolase L1 Rattus norvegicus 67-73 34204898-1 2021 Background: This study investigated the association of omega-3 polyunsaturated fatty acids (n-3 PUFA) within erythrocyte membranes and cardiovascular risk assessed by three different estimates. Fatty Acids, Omega-3 55-90 pumilio RNA binding family member 3 Homo sapiens 96-100 34237964-9 2021 DISCUSSION: The current meta-analysis demonstrated that omega-3 fatty acid supplementation for women with PCOS resulted in a statistical improvement in insulin, HOMA-IR, TC, triglyceride, LDL-C, VLDL-C, and HDL-C, but did not affect serum glucose. Fatty Acids, Omega-3 56-74 insulin Homo sapiens 152-159 34205419-4 2021 We highlight that Resvega , a combination of omega-3 fatty acids with an antioxidant, resveratrol, inhibits VEGF-A secretion in vitro by disrupting the dissociation of the VEGF-R2/Cav-1 complex into rafts and subsequently preventing MAPK activation. Fatty Acids, Omega-3 45-64 vascular endothelial growth factor A Homo sapiens 108-114 34205419-4 2021 We highlight that Resvega , a combination of omega-3 fatty acids with an antioxidant, resveratrol, inhibits VEGF-A secretion in vitro by disrupting the dissociation of the VEGF-R2/Cav-1 complex into rafts and subsequently preventing MAPK activation. Fatty Acids, Omega-3 45-64 kinase insert domain receptor Homo sapiens 172-179 34205419-4 2021 We highlight that Resvega , a combination of omega-3 fatty acids with an antioxidant, resveratrol, inhibits VEGF-A secretion in vitro by disrupting the dissociation of the VEGF-R2/Cav-1 complex into rafts and subsequently preventing MAPK activation. Fatty Acids, Omega-3 45-64 caveolin 1 Homo sapiens 180-185 34107720-7 2021 Repeated measures variance was used to analyze the effects of vitamin D and omega-3 fatty acids on insulin metabolism markers and blood lipid profiles. Fatty Acids, Omega-3 76-95 insulin Homo sapiens 99-106 34095193-6 2021 Several BACs such as omega-3 fatty acid, curcumin, vitamins, essential oils, antimicrobials, and probiotic bacteria can be encapsulated which exhibit immunological activity through different mechanisms. Fatty Acids, Omega-3 21-39 bacs None 8-12 34262728-12 2021 Furthermore, n-3 PUFA-FO brought about a decrease in malondialdehyde (MDA) levels but increased the activity of catalase (CAT) and glutathione peroxidase (GP), without changing superoxide dismutase (SOD) activity. Fatty Acids, Omega-3 13-21 catalase Mus musculus 112-120 34262728-12 2021 Furthermore, n-3 PUFA-FO brought about a decrease in malondialdehyde (MDA) levels but increased the activity of catalase (CAT) and glutathione peroxidase (GP), without changing superoxide dismutase (SOD) activity. Fatty Acids, Omega-3 13-21 catalase Mus musculus 122-125 34107720-11 2021 CONCLUSIONS: Combined supplementation with vitamin D and omega-3 fatty acids for 6 weeks in patients with GDM can effectively reduce blood sugar and blood lipids, improve HOMA-beta and insulin resistance, and ultimately effectively improve the glucose and lipid metabolism of patients. Fatty Acids, Omega-3 57-76 insulin Homo sapiens 185-192 35532744-6 2022 To exclude the possibility that the other ingredients in the chow may have taken the suppressive effect, fat-1 transgenic mice, which can produce n-3 PUFAs endogenously, demonstrated significant suppression of myopia. Fatty Acids, Omega-3 146-155 FAT atypical cadherin 1 Mus musculus 105-110 35561465-1 2022 Docosahexaenoic acid (DHA) is an n-3 polyunsaturated fatty acid (PUFA) that improves fertility by increasing membrane fluidity. Fatty Acids, Omega-3 33-63 PUFA Bos taurus 65-69 34825869-0 2021 Regulatory effects of N-3 PUFAs on pancreatic beta-cells and insulin-sensitive tissues. Fatty Acids, Omega-3 22-31 insulin Homo sapiens 61-68 34825869-1 2021 The N-3 polyunsaturated fatty acids (PUFAs) have a wide range of health benefits, including anti-inflammatory effects, improvements in lipids metabolism and promoting insulin secretion, as well as reduction of cancer risk. Fatty Acids, Omega-3 4-35 insulin Homo sapiens 167-174 34474084-4 2021 We demonstrate that each PLA2 has a unique preference between the specific omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the omega-6 arachidonic acid (AA), which are the precursors of most pro-inflammatory and anti-inflammatory or resolving eicosanoids and related oxylipins. Fatty Acids, Omega-3 75-94 phospholipase A2 group VI Homo sapiens 25-29 35584792-0 2022 Midlife omega-3 fatty acid intake predicts later life white matter microstructure in an age- and APOE-dependent manner. Fatty Acids, Omega-3 8-26 apolipoprotein E Homo sapiens 97-101 35584792-7 2022 Higher omega-3 intake correlated with greater restricted diffusion in the inferior longitudinal and inferior fronto-occipital fasciculus more strongly for apolipoprotein E (APOE) epsilon4 carriers than noncarriers. Fatty Acids, Omega-3 7-14 apolipoprotein E Homo sapiens 155-171 35584792-7 2022 Higher omega-3 intake correlated with greater restricted diffusion in the inferior longitudinal and inferior fronto-occipital fasciculus more strongly for apolipoprotein E (APOE) epsilon4 carriers than noncarriers. Fatty Acids, Omega-3 7-14 apolipoprotein E Homo sapiens 173-177 35468731-8 2022 A10-FMT improved T1D-disturbed gut microbiota, especially the increase in small intestinal lactobacillus, and blood and testicular metabolome to produce n-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to ameliorate spermatogenesis and semen quality. Fatty Acids, Omega-3 153-183 UDP glucuronosyltransferase 1 family, polypeptide A7C Mus musculus 0-3 35566382-0 2022 Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study. Fatty Acids, Omega-3 0-35 signal transducer and activator of transcription 3 Homo sapiens 108-113 35566382-11 2022 Here we report that n-3 PUFAs may be an ideal cancer chemo-preventive candidate by targeting STAT3 signaling, which is involved in cell proliferation and apoptosis. Fatty Acids, Omega-3 20-29 signal transducer and activator of transcription 3 Homo sapiens 93-98 35571243-7 2022 Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways. Fatty Acids, Omega-3 14-45 toll-like receptor 4 Mus musculus 86-90 35571243-7 2022 Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways. Fatty Acids, Omega-3 14-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 91-100 35571243-7 2022 Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways. Fatty Acids, Omega-3 14-45 caspase 1 Mus musculus 111-120 35565948-3 2022 This review focused on the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) on anxiety, depression, and cognition during the menopausal transition. Fatty Acids, Omega-3 38-73 pumilio RNA binding family member 3 Homo sapiens 79-83 35496049-15 2022 Conclusively, the combination of omega-3 and vitamin C demonstrated a synergistic therapeutic effect against MTX-intoxicated mice, hence representing a potential novel strategy for the management of drug-induced liver disorders. Fatty Acids, Omega-3 33-40 metaxin 1 Mus musculus 109-112 35517863-1 2022 The fatty acid dehydrogenase fat-1 gene, derived from Caenorhabditis elegans, encodes n-3 polyunsaturated fatty acid dehydrogenase (Delta15 desaturase) and catalyzes the 18-20-carbon n-6 polyunsaturated fatty acids (n-6 PUFA) to generate corresponding n-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 252-283 Omega-3 fatty acid desaturase fat-1 Caenorhabditis elegans 29-34 35517863-1 2022 The fatty acid dehydrogenase fat-1 gene, derived from Caenorhabditis elegans, encodes n-3 polyunsaturated fatty acid dehydrogenase (Delta15 desaturase) and catalyzes the 18-20-carbon n-6 polyunsaturated fatty acids (n-6 PUFA) to generate corresponding n-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 252-283 PUFA Bos taurus 220-224 35517863-1 2022 The fatty acid dehydrogenase fat-1 gene, derived from Caenorhabditis elegans, encodes n-3 polyunsaturated fatty acid dehydrogenase (Delta15 desaturase) and catalyzes the 18-20-carbon n-6 polyunsaturated fatty acids (n-6 PUFA) to generate corresponding n-3 polyunsaturated fatty acids (n-3 PUFA). Fatty Acids, Omega-3 252-283 PUFA Bos taurus 289-293 35157910-0 2022 Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E2 and suppress tumor growth in medulloblastoma. Fatty Acids, Omega-3 0-19 crystallin, alpha B Mus musculus 29-34 35139656-0 2022 NAD+ Levels Are Augmented in Aortic Tissue of ApoE-/- Mice by Dietary Omega-3 Fatty Acids. Fatty Acids, Omega-3 70-89 apolipoprotein E Mus musculus 46-50 35209939-0 2022 Effect of omega-3 fatty acids on TH1/TH2 polarization in individuals with high exposure to particulate matter <= 2.5 mum (PM2.5): a randomized, double-blind, placebo-controlled clinical study. Fatty Acids, Omega-3 10-29 negative elongation factor complex member C/D Homo sapiens 33-36 35139656-8 2022 RESULTS: NAD+, NADH, NADP+, NADPH, FAD+, FADH, and nicotinic acid adenine dinucleotide of the aortic arches were detected higher in the omega-3 polyunsaturated fatty acids-treated mice than the nontreated control. Fatty Acids, Omega-3 136-171 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 28-33 35467300-4 2022 RESULTS: After 14 days of immunonutritional therapy with omega-3 fatty acid or placebo, patients in the omega-3 group had significantly higher average NK cell activity (0.27 vs. 0.24, P=0.013) and lower percentages of TNF-alpha gene promoter methylation (25.7% vs. 60%, P<0.05) than the placebo group. Fatty Acids, Omega-3 57-75 tumor necrosis factor Homo sapiens 218-227 35467300-4 2022 RESULTS: After 14 days of immunonutritional therapy with omega-3 fatty acid or placebo, patients in the omega-3 group had significantly higher average NK cell activity (0.27 vs. 0.24, P=0.013) and lower percentages of TNF-alpha gene promoter methylation (25.7% vs. 60%, P<0.05) than the placebo group. Fatty Acids, Omega-3 104-111 tumor necrosis factor Homo sapiens 218-227 35467300-6 2022 CONCLUSION: The postoperative application of omega-3 fatty acid may improve the activity of NK cells, which is correlated to the methylation status of the TNF-alpha gene promoter. Fatty Acids, Omega-3 45-63 tumor necrosis factor Homo sapiens 155-164 34985587-0 2022 Retraction Note to: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study. Fatty Acids, Omega-3 20-38 microtubule associated protein tau Homo sapiens 136-140 35391753-10 2022 However, omega-3 supplementation reversed the I/R-related reduction in IL-4 in the paw muscle compared to groups supplemented with saline and corn oil. Fatty Acids, Omega-3 9-16 interleukin 4 Mus musculus 71-75 35391753-11 2022 Furthermore, omega-3 promoted the reduction of IL-10 levels in the paw skin, compared to animals with lesions supplemented with saline, until the 2nd-day post-CPIP. Fatty Acids, Omega-3 13-20 interleukin 10 Mus musculus 47-52 35391753-13 2022 Conclusion: The results suggest that omega-3 PUFA supplementation has anti-inflammatory effects in the CPIP model of CRPS-Type I, significantly reducing paw edema and regulating concentrations of anti-inflammatory cytokines, including IL-4 and IL-10. Fatty Acids, Omega-3 37-44 interleukin 4 Mus musculus 235-239 35391753-13 2022 Conclusion: The results suggest that omega-3 PUFA supplementation has anti-inflammatory effects in the CPIP model of CRPS-Type I, significantly reducing paw edema and regulating concentrations of anti-inflammatory cytokines, including IL-4 and IL-10. Fatty Acids, Omega-3 37-44 interleukin 10 Mus musculus 244-249 35150739-6 2022 A mouse model with inducible AT2 cell-specific deficiency of Mfsd2a exhibited AT2 cell hypertrophy with reduced total surfactant phospholipid levels due to reductions in the most abundant surfactants, phosphatidylcholine containing di-palmitic acid and phosphatidylcholine species containing the omega-3 fatty acid docosahexaenoic acid. Fatty Acids, Omega-3 296-314 major facilitator superfamily domain containing 2A Mus musculus 61-67 35187664-8 2022 In summary, we demonstrate that increased vacuolar TST activity may lead to optimized yield of an oil-seed crop species with high levels of healthy omega3 fatty acids in storage lipids. Fatty Acids, Omega-3 148-166 thiosulfate sulfurtransferase Solanum lycopersicum 51-54 35017005-9 2022 In the fasted state, mice fed either N3-PUFA accumulated less liver TAG, had lower plasma NEFA, and suppressed eWAT HSL activity compared to lard. Fatty Acids, Omega-3 37-44 lipase, hormone sensitive Mus musculus 116-119 35381532-9 2022 IL-6, TNF-alpha, TGF-beta, and IL-10 were attenuated in all O3FA groups. Fatty Acids, Omega-3 60-64 interleukin 6 Rattus norvegicus 0-4 35381532-9 2022 IL-6, TNF-alpha, TGF-beta, and IL-10 were attenuated in all O3FA groups. Fatty Acids, Omega-3 60-64 tumor necrosis factor Rattus norvegicus 6-15 35381532-9 2022 IL-6, TNF-alpha, TGF-beta, and IL-10 were attenuated in all O3FA groups. Fatty Acids, Omega-3 60-64 transforming growth factor alpha Rattus norvegicus 17-25 35381532-9 2022 IL-6, TNF-alpha, TGF-beta, and IL-10 were attenuated in all O3FA groups. Fatty Acids, Omega-3 60-64 interleukin 10 Rattus norvegicus 31-36 35240690-2 2022 Based on the anti-inflammatory properties and mitigating effects on IR and stress of n-3 polyunsaturated fatty acids (n-3 PUFA), an experiment was performed to evaluate the effect of n-3 PUFA supplementation to feedlot-finished steers during summer on animal performance, physiological and biochemical variables associated with glucose metabolism, heat and pre-slaughter-induced stress, and meat quality. Fatty Acids, Omega-3 85-116 PUFA Bos taurus 122-126 34981516-1 2022 There are conflicting findings over the bioavailability of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) from krill oil (KO) compared with fish oil (FO) in short- and long-term studies. Fatty Acids, Omega-3 70-101 pumilio RNA binding family member 3 Homo sapiens 107-111 35193914-2 2022 The objective of this review was to: retrieve, synthesise and assess the quality of evidence (confidence) for nutrigenetic approaches related to the effect of genetic variation on plasma lipid, lipoprotein and apolipoprotein responsiveness to omega-3 fatty acid intake. Fatty Acids, Omega-3 243-261 apolipoprotein E Homo sapiens 210-224 35237638-3 2021 Objective: To provide guidance for clinical practice related to genetic testing for evaluating responsiveness to dietary/supplemental omega-3s and their impact on plasma lipids/lipoproteins/apolipoproteins. Fatty Acids, Omega-3 134-142 apolipoprotein E Homo sapiens 190-205 35157107-6 2022 Both concentration and composition of the SFA and SFA plus n-3 polyunsaturated fatty acids (PUFA) mixtures had significant effects on genes involved in the PI3K/Akt pathway. Fatty Acids, Omega-3 59-90 AKT serine/threonine kinase 1 Homo sapiens 161-164 35237638-7 2021 However, two gene-diet associations with strong evidence (GRADE quality: moderate and high) can be considered for implementation into clinical practice in certain cases: male APOE-E4 carriers (rs429358, rs7412) and TG changes in response to the omega-3 fatty acids eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) as well as a 31-SNP nutrigenetic risk score and TG changes in response to EPA+DHA among adults with overweight/obesity. Fatty Acids, Omega-3 245-264 apolipoprotein E Homo sapiens 175-179 35237645-1 2022 Flaxseed supplementation in diet of dairy cow can effectively enhance the production of omega-3 polyunsaturated fatty acids (n-3 PUFA) in raw milk, which further give rise to the changes of volatile organic compounds (VOCs). Fatty Acids, Omega-3 88-123 PUFA Bos taurus 129-133 35163842-7 2022 omega-3 fatty acids (e.g., docosahexaenoic acid) appear to be less prevalent in obese patient RBCs, and this is the case for both the global fatty acid distribution and for the individual major lipids in the membrane phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS). Fatty Acids, Omega-3 0-19 pyruvate carboxylase Homo sapiens 238-240 35112608-1 2022 The use of omega-3 polyunsaturated fatty acids (n-3 PUFA) has been studied in physically active population, however, there is a lack of information about the effects of n-3 PUFA supplementation on people with a sedentary behavior or who are undergoing a period of limb immobilization. Fatty Acids, Omega-3 11-46 pumilio RNA binding family member 3 Homo sapiens 52-56 35047577-5 2021 A transgenic fat-1 mouse model carrying the n-3 fatty acid desaturase gene fat-1 gene from Caenorhabditis elegans was used to evaluate the mechanism of n-3 PUFAs in this disease. Fatty Acids, Omega-3 44-58 FAT atypical cadherin 1 Mus musculus 75-80 35090386-0 2022 Omega-3 fatty acids impair miR-1-3p-dependent Notch3 down-regulation and alleviate sepsis-induced intestinal injury. Fatty Acids, Omega-3 0-19 notch 3 Mus musculus 46-52 35090386-7 2022 RESULTS: Omega-3 FAs inhibited CLP-induced intestinal injury and ameliorated LPS-induced intestinal epithelial cell injury by down-regulating miR-1-3p, as evidenced by decreased levels of tumor necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6, in addition to diminished levels of reactive oxygen species, malondialdehyde levels and superoxide dismutase activity. Fatty Acids, Omega-3 9-20 tumor necrosis factor Mus musculus 188-215 35090386-7 2022 RESULTS: Omega-3 FAs inhibited CLP-induced intestinal injury and ameliorated LPS-induced intestinal epithelial cell injury by down-regulating miR-1-3p, as evidenced by decreased levels of tumor necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6, in addition to diminished levels of reactive oxygen species, malondialdehyde levels and superoxide dismutase activity. Fatty Acids, Omega-3 9-20 interleukin 1 beta Mus musculus 217-234 35090386-7 2022 RESULTS: Omega-3 FAs inhibited CLP-induced intestinal injury and ameliorated LPS-induced intestinal epithelial cell injury by down-regulating miR-1-3p, as evidenced by decreased levels of tumor necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6, in addition to diminished levels of reactive oxygen species, malondialdehyde levels and superoxide dismutase activity. Fatty Acids, Omega-3 9-20 interleukin 1 alpha Mus musculus 236-244 35090386-7 2022 RESULTS: Omega-3 FAs inhibited CLP-induced intestinal injury and ameliorated LPS-induced intestinal epithelial cell injury by down-regulating miR-1-3p, as evidenced by decreased levels of tumor necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6, in addition to diminished levels of reactive oxygen species, malondialdehyde levels and superoxide dismutase activity. Fatty Acids, Omega-3 9-20 interleukin 6 Mus musculus 250-254 34986656-7 2022 The highest GLP-1 levels were in ALA (0.70 ng/mL) and DHA (0.67 ng/mL) supplemented groups at 60th and 120th min indicating n-3 fatty acids efficiency on satiety compared to LA. Fatty Acids, Omega-3 124-139 glucagon Rattus norvegicus 12-17 35040258-10 2022 In conclusion, n-3 PUFAs improve atherosclerosis in Fat-1 transgenic rabbits, and this process may depend on the increase in plasma HDL-C and the decrease in the amount of SMCs in atherosclerotic plaques. Fatty Acids, Omega-3 15-24 LOW QUALITY PROTEIN: protocadherin Fat 1 Oryctolagus cuniculus 52-57 35089938-1 2022 The current study aimed to further address important questions regarding the therapeutic efficacy of omega-3 fatty acids for various behavioral and neuroimmune aspects of the Fmr1 phenotype. Fatty Acids, Omega-3 101-120 fragile X messenger ribonucleoprotein 1 Mus musculus 175-179 35089938-5 2022 The post-weaning Omega-3 diet reduced hippocampal expression of IL-6 and this reduction of IL-6 was significantly associated with diminished performance in the fear conditioning task. Fatty Acids, Omega-3 17-24 interleukin 6 Mus musculus 64-68 35089938-5 2022 The post-weaning Omega-3 diet reduced hippocampal expression of IL-6 and this reduction of IL-6 was significantly associated with diminished performance in the fear conditioning task. Fatty Acids, Omega-3 17-24 interleukin 6 Mus musculus 91-95 35075215-0 2022 Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation-dependence on GPR120. Fatty Acids, Omega-3 19-38 free fatty acid receptor 4 Mus musculus 161-167 35075215-1 2022 BACKGROUND: The antiprostate cancer effects of dietary omega-3 fatty acids (FAs) were previously found to be dependent on host G-protein coupled receptor 120 (GPR120). Fatty Acids, Omega-3 55-74 free fatty acid receptor 4 Mus musculus 127-157 35075215-1 2022 BACKGROUND: The antiprostate cancer effects of dietary omega-3 fatty acids (FAs) were previously found to be dependent on host G-protein coupled receptor 120 (GPR120). Fatty Acids, Omega-3 55-74 free fatty acid receptor 4 Mus musculus 159-165 35075215-11 2022 Given the central role of M2-like macrophages in prostate cancer progression, GPR120-dependent omega-3 FA inhibition of M2-like macrophages may play an important role in prostate cancer therapeutics. Fatty Acids, Omega-3 95-105 free fatty acid receptor 4 Mus musculus 78-84 35052622-0 2022 Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary DNA Adducts and Cytochrome P450 (CYP)1B1 by Dietary Antioxidants, Omega-3 Fatty Acids, in Mice. Fatty Acids, Omega-3 138-157 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 88-112 35052622-13 2022 Our results suggest that a combination of mechanism entailing CYP1B1 inhibition and the modulation of DNA repair genes contribute to the attenuation of PAH-mediated carcinogenesis by omega 3 fatty acids. Fatty Acids, Omega-3 183-202 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 62-68 35527006-11 2022 Omega-3 significantly upregulated Nrf2 nuclear expression and HO-1 expression after prenatal lead exposure. Fatty Acids, Omega-3 0-7 nuclear factor, erythroid derived 2, like 2 Mus musculus 34-38 35527006-11 2022 Omega-3 significantly upregulated Nrf2 nuclear expression and HO-1 expression after prenatal lead exposure. Fatty Acids, Omega-3 0-7 heme oxygenase 1 Mus musculus 62-66 35527006-12 2022 Overall, omega-3 supplementation significantly elevated the BDNF/TrkB/CREB pathway and restores anti-oxidants by upregulating the Nrf2/HO-1, thereby improving cognitive function in offspring after prenatal lead exposure. Fatty Acids, Omega-3 9-16 brain derived neurotrophic factor Mus musculus 60-64 35527006-12 2022 Overall, omega-3 supplementation significantly elevated the BDNF/TrkB/CREB pathway and restores anti-oxidants by upregulating the Nrf2/HO-1, thereby improving cognitive function in offspring after prenatal lead exposure. Fatty Acids, Omega-3 9-16 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 65-69 35527006-12 2022 Overall, omega-3 supplementation significantly elevated the BDNF/TrkB/CREB pathway and restores anti-oxidants by upregulating the Nrf2/HO-1, thereby improving cognitive function in offspring after prenatal lead exposure. Fatty Acids, Omega-3 9-16 cAMP responsive element binding protein 1 Mus musculus 70-74 35527006-12 2022 Overall, omega-3 supplementation significantly elevated the BDNF/TrkB/CREB pathway and restores anti-oxidants by upregulating the Nrf2/HO-1, thereby improving cognitive function in offspring after prenatal lead exposure. Fatty Acids, Omega-3 9-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 130-134 35527006-12 2022 Overall, omega-3 supplementation significantly elevated the BDNF/TrkB/CREB pathway and restores anti-oxidants by upregulating the Nrf2/HO-1, thereby improving cognitive function in offspring after prenatal lead exposure. Fatty Acids, Omega-3 9-16 heme oxygenase 1 Mus musculus 135-139 35527006-8 2022 The protein and mRNA levels of BDNF, TrkB and CREB in the prenatal lead exposure group were significantly upregulated by omega-3 supplementation. Fatty Acids, Omega-3 121-128 brain derived neurotrophic factor Mus musculus 31-35 35527006-8 2022 The protein and mRNA levels of BDNF, TrkB and CREB in the prenatal lead exposure group were significantly upregulated by omega-3 supplementation. Fatty Acids, Omega-3 121-128 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 37-41 35527006-8 2022 The protein and mRNA levels of BDNF, TrkB and CREB in the prenatal lead exposure group were significantly upregulated by omega-3 supplementation. Fatty Acids, Omega-3 121-128 cAMP responsive element binding protein 1 Mus musculus 46-50 35527006-10 2022 Omega-3 restored anti-oxidants SOD, GSH and CAT to control levels after prenatal lead exposure. Fatty Acids, Omega-3 0-7 catalase Mus musculus 44-47