PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35572840-14	2022	Conclusion: In summary, these findings provide the first evidence that alisol B 23-acetate improves the anticancer activity of bufalin on liver cancer through activation of the Wnt/beta-catenin axis, and these outcomes might shed new lights on exploring the new methods against liver cancer.	alisol B monoacetate	80-90	catenin beta 1	Homo sapiens	181-193
10549876-1	1999	Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3).	alisol B monoacetate	168-188	nitric oxide synthase 2, inducible	Mus musculus	124-128
33616795-9	2021	We found that two triterpenes 16-hydroxy-alisol B 23-acetate and alisol M 23-acetate showed favorable ADMET properties and high binding affinity against LXRbeta.	alisol B monoacetate	50-60	nuclear receptor subfamily 1 group H member 3	Homo sapiens	153-160
33616795-9	2021	We found that two triterpenes 16-hydroxy-alisol B 23-acetate and alisol M 23-acetate showed favorable ADMET properties and high binding affinity against LXRbeta.	alisol B monoacetate	74-84	nuclear receptor subfamily 1 group H member 3	Homo sapiens	153-160
24915879-4	2014	Indeed, in the transient transfection reporter assays, alisol M 23-acetate and alisol A 23-acetate transactivated AR in dose-dependent manner, while they transrepressed the transactivation effects exerted by agonist-activated PR and GR.	alisol B monoacetate	64-74	androgen receptor	Homo sapiens	114-116
24915879-4	2014	Indeed, in the transient transfection reporter assays, alisol M 23-acetate and alisol A 23-acetate transactivated AR in dose-dependent manner, while they transrepressed the transactivation effects exerted by agonist-activated PR and GR.	alisol B monoacetate	64-74	nuclear receptor subfamily 3 group C member 1	Homo sapiens	233-235
24915879-4	2014	Indeed, in the transient transfection reporter assays, alisol M 23-acetate and alisol A 23-acetate transactivated AR in dose-dependent manner, while they transrepressed the transactivation effects exerted by agonist-activated PR and GR.	alisol B monoacetate	88-98	androgen receptor	Homo sapiens	114-116
24915879-6	2014	All these results indicate that alisol M 23-acetate and alisol A 23-acetate from Alisma orientalis might possess therapeutic effects through their modulation of AR, PR, and GR pathways.	alisol B monoacetate	41-51	androgen receptor	Homo sapiens	161-163
24915879-6	2014	All these results indicate that alisol M 23-acetate and alisol A 23-acetate from Alisma orientalis might possess therapeutic effects through their modulation of AR, PR, and GR pathways.	alisol B monoacetate	41-51	progesterone receptor	Homo sapiens	165-167
24915879-6	2014	All these results indicate that alisol M 23-acetate and alisol A 23-acetate from Alisma orientalis might possess therapeutic effects through their modulation of AR, PR, and GR pathways.	alisol B monoacetate	41-51	nuclear receptor subfamily 3 group C member 1	Homo sapiens	173-175
19533808-0	2009	Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways.	alisol B monoacetate	0-16	sarcoglycan beta	Homo sapiens	38-41
23037162-6	2012	Moreover, the principal components of Alismatis Rhizoma, Alisol A, Alisol B, and Alisol B acetate, were found to increase the sensitivity to paclitaxel in HuH-7/PTX by inhibiting drug export by MDR-1 without affecting the expression levels of MDR-1.	alisol B monoacetate	81-97	MIR7-3 host gene	Homo sapiens	155-160
23037162-6	2012	Moreover, the principal components of Alismatis Rhizoma, Alisol A, Alisol B, and Alisol B acetate, were found to increase the sensitivity to paclitaxel in HuH-7/PTX by inhibiting drug export by MDR-1 without affecting the expression levels of MDR-1.	alisol B monoacetate	81-97	ATP binding cassette subfamily B member 1	Homo sapiens	194-199
23037162-6	2012	Moreover, the principal components of Alismatis Rhizoma, Alisol A, Alisol B, and Alisol B acetate, were found to increase the sensitivity to paclitaxel in HuH-7/PTX by inhibiting drug export by MDR-1 without affecting the expression levels of MDR-1.	alisol B monoacetate	81-97	ATP binding cassette subfamily B member 1	Homo sapiens	243-248
19533808-0	2009	Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways.	alisol B monoacetate	0-16	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	74-104
19533808-0	2009	Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways.	alisol B monoacetate	0-16	AKT serine/threonine kinase 1	Homo sapiens	105-108
12907291-6	2003	Alisol B acetate, but not saikosaponin-d, induced G2/M arrest of the cell cycle as well as a significant increase in caspase-3 activity.	alisol B monoacetate	0-16	caspase 3	Homo sapiens	117-126
16399228-0	2006	Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells.	alisol B monoacetate	0-16	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
16399228-4	2006	Alisol B acetate induced Bax up-regulation and nuclear translocation; it also induced the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.	alisol B monoacetate	0-16	BCL2 associated X, apoptosis regulator	Homo sapiens	25-28
16399228-4	2006	Alisol B acetate induced Bax up-regulation and nuclear translocation; it also induced the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.	alisol B monoacetate	0-16	caspase 8	Homo sapiens	114-123
16399228-4	2006	Alisol B acetate induced Bax up-regulation and nuclear translocation; it also induced the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.	alisol B monoacetate	0-16	caspase 9	Homo sapiens	128-137
16399228-4	2006	Alisol B acetate induced Bax up-regulation and nuclear translocation; it also induced the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.	alisol B monoacetate	0-16	caspase 3	Homo sapiens	152-161
16399228-5	2006	Taken together, it is suggested that alisol B acetate induces apoptosis in PC-3 cells via a mitochondria-mediated mechanism with activation of caspase-8, -9 and -3.	alisol B monoacetate	37-53	caspase 8	Homo sapiens	143-163
12907291-8	2003	We suggest that alisol B acetate and saikosaponin-d induced cell apoptosis through the caspase-3-dependent and -independent pathways, respectively.	alisol B monoacetate	16-32	caspase 3	Homo sapiens	87-96