PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23778113-5	2013	In this report, we provide evidence that aluminum-sulfate, when incubated with microglial cells, induces the up-regulation of an NF-kB-sensitive micro RNA-34a (miRNA-34a; chr1p36) that is known to target the TREM2 mRNA 3"-untranslated region (3"-UTR), significantly down-regulating TREM2 expression.	aluminum sulfate	41-57	microRNA 34a	Mus musculus	145-158
23778113-5	2013	In this report, we provide evidence that aluminum-sulfate, when incubated with microglial cells, induces the up-regulation of an NF-kB-sensitive micro RNA-34a (miRNA-34a; chr1p36) that is known to target the TREM2 mRNA 3"-untranslated region (3"-UTR), significantly down-regulating TREM2 expression.	aluminum sulfate	41-57	triggering receptor expressed on myeloid cells 2	Mus musculus	208-213
23778113-5	2013	In this report, we provide evidence that aluminum-sulfate, when incubated with microglial cells, induces the up-regulation of an NF-kB-sensitive micro RNA-34a (miRNA-34a; chr1p36) that is known to target the TREM2 mRNA 3"-untranslated region (3"-UTR), significantly down-regulating TREM2 expression.	aluminum sulfate	41-57	triggering receptor expressed on myeloid cells 2	Mus musculus	282-287
24006511-6	2013	In addition, they totally prevented the IL-1beta release induced by SFAs and, with less efficiency, by a broad range of NLRP3 inducers, including nigericin, alum, and monosodium urate.	aluminum sulfate	157-161	interleukin 1 beta	Homo sapiens	40-48
24127597-4	2013	Recent studies indicate that the reactive oxygen species produced by mitochondrial respiration is critical for the activation of the NLRP3 inflammasome by monosodium urate, alum, and ATP.	aluminum sulfate	173-177	NLR family pyrin domain containing 3	Homo sapiens	133-138
23532736-5	2013	Tolerance induction was facilitated when anti-CD4 mAbs were administered together with FVIII adsorbed in an adjuvant (alum).	aluminum sulfate	118-122	coagulation factor VIII	Mus musculus	87-92
23335993-2	2013	Currently, the commercially available HBV vaccine is combined with alum adjuvant, which stimulates mainly Th2 immune responses.	aluminum sulfate	67-80	heart and neural crest derivatives expressed 2	Mus musculus	106-109
23557144-4	2013	METHODS: On the grounds of preliminary investigations in 252 patients with alum-associated ASIA showing both a selective increase of circulating CCL2, the major monocyte chemoattractant, and a variation in the CCL2 gene, we designed mouse experiments to assess biodistribution of vaccine-derived aluminum and of alum-particle fluorescent surrogates injected in muscle.	aluminum sulfate	75-79	C-C motif chemokine ligand 2	Homo sapiens	145-149
23557144-4	2013	METHODS: On the grounds of preliminary investigations in 252 patients with alum-associated ASIA showing both a selective increase of circulating CCL2, the major monocyte chemoattractant, and a variation in the CCL2 gene, we designed mouse experiments to assess biodistribution of vaccine-derived aluminum and of alum-particle fluorescent surrogates injected in muscle.	aluminum sulfate	75-79	C-C motif chemokine ligand 2	Homo sapiens	210-214
23592988-6	2013	In contrast, a current licensed Pa, administered with alum as the adjuvant, induced Th2 and Th17 cells, but weak Th1 responses.	aluminum sulfate	54-58	heart and neural crest derivatives expressed 2	Mus musculus	84-87
21798617-1	2012	OBJECTIVE: To modulate atherosclerosis by combining subcutaneous immunization with heat shock protein 65 (hsp65) in alum adjuvant and anti-CD45RB monoclonal antibodies (mAb).	aluminum sulfate	116-120	heat shock protein 1 (chaperonin)	Mus musculus	83-104
22587593-2	2012	We aimed to study the immunomodulatory effect of glutamic acid decarboxylase (GAD) 65 formulated with aluminium hydroxide (GAD-alum) in children with Type 1 diabetes, focusing on chemokines and their receptors.	aluminum sulfate	102-106	glutamate decarboxylase 1	Homo sapiens	49-76
22587593-2	2012	We aimed to study the immunomodulatory effect of glutamic acid decarboxylase (GAD) 65 formulated with aluminium hydroxide (GAD-alum) in children with Type 1 diabetes, focusing on chemokines and their receptors.	aluminum sulfate	102-106	glutamate decarboxylase 1	Homo sapiens	78-81
22587593-2	2012	We aimed to study the immunomodulatory effect of glutamic acid decarboxylase (GAD) 65 formulated with aluminium hydroxide (GAD-alum) in children with Type 1 diabetes, focusing on chemokines and their receptors.	aluminum sulfate	102-106	glutamate decarboxylase 1	Homo sapiens	123-126
21798617-1	2012	OBJECTIVE: To modulate atherosclerosis by combining subcutaneous immunization with heat shock protein 65 (hsp65) in alum adjuvant and anti-CD45RB monoclonal antibodies (mAb).	aluminum sulfate	116-120	heat shock protein 1 (chaperonin)	Mus musculus	106-111
22099153-3	2011	In this study we analyzed abundances miRNA-125b and miRNA-146a in magnesium-, iron-, gallium, and aluminum-sulfate-stressed human-astroglial (HAG) cells, a structural and immune-responsive brain cell type.	aluminum sulfate	98-114	microRNA 146a	Homo sapiens	52-62
22099153-4	2011	The combination of iron- plus aluminum-sulfate was found to be significantly synergistic in up-regulating reactive oxygen species (ROS) abundance, NF-kB-DNA binding and miRNA-125b and miRNA-146a expression.	aluminum sulfate	30-46	microRNA 146a	Homo sapiens	184-194
21714999-4	2011	METHODS: Patients aged 3-45 years who had been diagnosed with type 1 diabetes for less than 100 days were enrolled from 15 sites in the USA and Canada, and randomly assigned to receive one of three treatments: three injections of 20 mug GAD-alum, two injections of 20 mug GAD-alum and one of alum, or 3 injections of alum.	aluminum sulfate	241-245	glutamate decarboxylase 1	Homo sapiens	237-240
21714999-13	2011	At 1 year, the 2-h AUC of C-peptide, adjusted for age, sex, and baseline C-peptide value, was 0 412 nmol/L (95% CI 0 349-0 478) in the GAD-alum group, 0 382 nmol/L (0 322-0 446) in the GAD-alum plus alum group, and 0 413 nmol/L (0 351-0 477) in the alum group.	aluminum sulfate	139-143	glutamate decarboxylase 1	Homo sapiens	135-138
21714999-13	2011	At 1 year, the 2-h AUC of C-peptide, adjusted for age, sex, and baseline C-peptide value, was 0 412 nmol/L (95% CI 0 349-0 478) in the GAD-alum group, 0 382 nmol/L (0 322-0 446) in the GAD-alum plus alum group, and 0 413 nmol/L (0 351-0 477) in the alum group.	aluminum sulfate	139-143	glutamate decarboxylase 1	Homo sapiens	185-188
21714999-13	2011	At 1 year, the 2-h AUC of C-peptide, adjusted for age, sex, and baseline C-peptide value, was 0 412 nmol/L (95% CI 0 349-0 478) in the GAD-alum group, 0 382 nmol/L (0 322-0 446) in the GAD-alum plus alum group, and 0 413 nmol/L (0 351-0 477) in the alum group.	aluminum sulfate	189-193	glutamate decarboxylase 1	Homo sapiens	135-138
21714999-14	2011	The ratio of the population mean of the adjusted geometric mean 2-h AUC of C-peptide was 0 998 (95% CI 0 779-1 22; p=0 98) for GAD-alum versus alum, and 0 926 (0 720-1 13; p=0 50) for GAD-alum plus alum versus alum.	aluminum sulfate	131-135	glutamate decarboxylase 1	Homo sapiens	127-130
21477796-5	2011	Alum in Gardasil, Alum and 3-O-deacylated-4"-monophosphoryl lipid A (ASO4) in Cervarix may stimulate IL10 production and inhibit the Th1, CTL immune response of immunized individuals.	aluminum sulfate	0-4	interleukin 10	Homo sapiens	101-105
21159849-4	2011	Afterwards, mice were sensitized to chicken egg ovalbumin (OVA) precipitated in aluminium sulphate and then intranasally challenged with OVA to induce allergic lung inflammation.	aluminum sulfate	80-98	ovalbumin (SERPINB14)	Gallus gallus	48-57
21159849-4	2011	Afterwards, mice were sensitized to chicken egg ovalbumin (OVA) precipitated in aluminium sulphate and then intranasally challenged with OVA to induce allergic lung inflammation.	aluminum sulfate	80-98	ovalbumin (SERPINB14)	Gallus gallus	59-62
21477796-5	2011	Alum in Gardasil, Alum and 3-O-deacylated-4"-monophosphoryl lipid A (ASO4) in Cervarix may stimulate IL10 production and inhibit the Th1, CTL immune response of immunized individuals.	aluminum sulfate	0-4	negative elongation factor complex member C/D	Homo sapiens	133-136
21044870-2	2011	We have shown that treatment with alum-formulated glutamic acid decarboxylase 65 (GAD-alum) preserved residual insulin secretion and induced antigen-specific responses in children with recent onset type 1 diabetes.	aluminum sulfate	34-38	glutamate decarboxylase 1	Homo sapiens	82-85
21044870-5	2011	GAD(65)-stimulation enhanced the percentage of CD4(+)CD25(high)FOXP3(+) cells, but reduced the percentage of CD4(+)CD25(+) cells, in samples from the GAD-alum treated group.	aluminum sulfate	154-158	glutamate decarboxylase 1	Homo sapiens	0-3
21044870-5	2011	GAD(65)-stimulation enhanced the percentage of CD4(+)CD25(high)FOXP3(+) cells, but reduced the percentage of CD4(+)CD25(+) cells, in samples from the GAD-alum treated group.	aluminum sulfate	154-158	glutamate decarboxylase 1	Homo sapiens	150-153
19851830-7	2010	The animals immunized with GroEL + CFA or GroEL-alone showed higher IFN-gamma and IL-2 levels than alum group, indicating Th1 response whereas IL-4 levels (Th2 response) were found to be highest in alum group as compared to other two immunized groups.	aluminum sulfate	99-103	heat shock protein family D (Hsp60) member 1	Homo sapiens	27-32
21263221-0	2011	Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet beta cells?	aluminum sulfate	37-41	glutamate decarboxylase 2	Homo sapiens	53-58
21263221-0	2011	Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet beta cells?	aluminum sulfate	37-41	insulin	Homo sapiens	67-74
22046441-11	2011	Moreover, the constitutive knockdown of the IFI16 expression in THP-1 cells increased the basal and induced [induced by poly(dA:dT) or alum] activation of the caspase-1 by the AIM2 and NLRP3 inflammasomes.	aluminum sulfate	135-139	interferon gamma inducible protein 16	Homo sapiens	44-49
22046441-11	2011	Moreover, the constitutive knockdown of the IFI16 expression in THP-1 cells increased the basal and induced [induced by poly(dA:dT) or alum] activation of the caspase-1 by the AIM2 and NLRP3 inflammasomes.	aluminum sulfate	135-139	caspase 1	Homo sapiens	159-168
22046441-11	2011	Moreover, the constitutive knockdown of the IFI16 expression in THP-1 cells increased the basal and induced [induced by poly(dA:dT) or alum] activation of the caspase-1 by the AIM2 and NLRP3 inflammasomes.	aluminum sulfate	135-139	absent in melanoma 2	Homo sapiens	176-180
19404608-1	2009	AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function.	aluminum sulfate	135-139	glutamate decarboxylase 2	Homo sapiens	77-82
19540598-3	2009	Here we provide evidence in human neural (HN) cells of an aluminum-sulfate- and reactive oxygen species (ROS)-mediated up-regulation of an NF-kappaB-sensitive miRNA-146a that down-regulates the expression of complement factor H (CFH), an important repressor of inflammation.	aluminum sulfate	58-74	nuclear factor kappa B subunit 1	Homo sapiens	139-148
19540598-3	2009	Here we provide evidence in human neural (HN) cells of an aluminum-sulfate- and reactive oxygen species (ROS)-mediated up-regulation of an NF-kappaB-sensitive miRNA-146a that down-regulates the expression of complement factor H (CFH), an important repressor of inflammation.	aluminum sulfate	58-74	microRNA 146a	Homo sapiens	159-169
19540598-3	2009	Here we provide evidence in human neural (HN) cells of an aluminum-sulfate- and reactive oxygen species (ROS)-mediated up-regulation of an NF-kappaB-sensitive miRNA-146a that down-regulates the expression of complement factor H (CFH), an important repressor of inflammation.	aluminum sulfate	58-74	complement factor H	Homo sapiens	208-227
19540598-3	2009	Here we provide evidence in human neural (HN) cells of an aluminum-sulfate- and reactive oxygen species (ROS)-mediated up-regulation of an NF-kappaB-sensitive miRNA-146a that down-regulates the expression of complement factor H (CFH), an important repressor of inflammation.	aluminum sulfate	58-74	complement factor H	Homo sapiens	229-232
19540598-6	2009	An NF-kappaB-containing miRNA-146a-promoter-luciferase reporter construct transfected into HN cells showed significant up-regulation of miRNA-146a after aluminum-sulfate treatment that corresponded to decreased CFH gene expression.	aluminum sulfate	153-169	nuclear factor kappa B subunit 1	Homo sapiens	3-12
19540598-6	2009	An NF-kappaB-containing miRNA-146a-promoter-luciferase reporter construct transfected into HN cells showed significant up-regulation of miRNA-146a after aluminum-sulfate treatment that corresponded to decreased CFH gene expression.	aluminum sulfate	153-169	microRNA 146a	Homo sapiens	24-34
19540598-6	2009	An NF-kappaB-containing miRNA-146a-promoter-luciferase reporter construct transfected into HN cells showed significant up-regulation of miRNA-146a after aluminum-sulfate treatment that corresponded to decreased CFH gene expression.	aluminum sulfate	153-169	microRNA 146a	Homo sapiens	136-146
19540598-6	2009	An NF-kappaB-containing miRNA-146a-promoter-luciferase reporter construct transfected into HN cells showed significant up-regulation of miRNA-146a after aluminum-sulfate treatment that corresponded to decreased CFH gene expression.	aluminum sulfate	153-169	complement factor H	Homo sapiens	211-214
19404608-1	2009	AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function.	aluminum sulfate	135-139	glutamate decarboxylase 2	Homo sapiens	163-168
19404608-1	2009	AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function.	aluminum sulfate	135-139	glutamate decarboxylase 1	Homo sapiens	77-80
18055199-1	2008	Alkyl- or aryl-14H-dibenzo[a,j]xanthene derivatives are synthesized efficiently by the reaction of beta-naphthol and aliphatic and aromatic aldehydes in the presence of KAl(SO4)2 x 12 H2O (alum) under aqueous condition at 100 degrees C. Different types of aromatic and aliphatic aldehydes are used in the reaction and in all cases the products synthesized successfully.	aluminum sulfate	189-193	anosmin 1	Homo sapiens	169-172
18634826-6	2008	It was found that Th1 type cytokine interferon gamma (IFN gamma) was elevated in the CFA-treated group, while Th2 type cytokine interleukin-4 (IL-4) was increased in the Alum-treated group.	aluminum sulfate	170-174	interleukin 4	Mus musculus	128-141
18634826-6	2008	It was found that Th1 type cytokine interferon gamma (IFN gamma) was elevated in the CFA-treated group, while Th2 type cytokine interleukin-4 (IL-4) was increased in the Alum-treated group.	aluminum sulfate	170-174	interleukin 4	Mus musculus	143-147
18555566-8	2008	Moreover, alum (0.2 mg) only induces IgG and IgG1 antibody responses to OVA in mice.	aluminum sulfate	10-14	LOC105243590	Mus musculus	45-49
19016524-5	2008	Upon immunization with OVA and aluminum potassium sulfate, APRIL(-/-) mice responded with an increased antigen-specific IgG1 response.	aluminum sulfate	31-57	LOC105243590	Mus musculus	120-124
18228200-4	2008	In this study, we investigated the correlation between the expression of Abeta and GRP78 in the brain cortex of mice chronically treated with aluminium sulphate.	aluminum sulfate	142-160	amyloid beta (A4) precursor protein	Mus musculus	73-78
18228200-4	2008	In this study, we investigated the correlation between the expression of Abeta and GRP78 in the brain cortex of mice chronically treated with aluminium sulphate.	aluminum sulfate	142-160	heat shock protein 5	Mus musculus	83-88
18228200-5	2008	Chronic exposure over 12 months to aluminium sulphate in drinking water resulted in deposition of Abeta similar to that seen in congophilic amyloid angiopathy (CAA) in humans and a reduction in neuronal expression of GRP78 similar to what has previously been observed in Alzheimer"s disease.	aluminum sulfate	35-53	amyloid beta precursor protein	Homo sapiens	98-103
18228200-5	2008	Chronic exposure over 12 months to aluminium sulphate in drinking water resulted in deposition of Abeta similar to that seen in congophilic amyloid angiopathy (CAA) in humans and a reduction in neuronal expression of GRP78 similar to what has previously been observed in Alzheimer"s disease.	aluminum sulfate	35-53	heat shock protein family A (Hsp70) member 5	Homo sapiens	217-222
16368167-0	2006	Prototype Alzheimer"s disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.	aluminum sulfate	104-108	amyloid beta precursor protein	Homo sapiens	75-80
16890767-3	2006	METHODS: BALB/c mice were sensitized with ovalbumin (OVA) in the presence of aluminum potassium sulfate and then subjected to intragastric saline or OVA challenges.	aluminum sulfate	77-103	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	42-51
16890767-3	2006	METHODS: BALB/c mice were sensitized with ovalbumin (OVA) in the presence of aluminum potassium sulfate and then subjected to intragastric saline or OVA challenges.	aluminum sulfate	77-103	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	53-56
15522332-1	2005	A physicochemical treatment (coagulation-flocculation) was applied to a slaughterhouse wastewater, using anionic polyacrylamide as coagulant aid to improve the settling velocity of the flocs formed with the coagulants used: ferric sulphate, aluminium sulphate and polyaluminium chloride.	aluminum sulfate	241-259	activation induced cytidine deaminase	Homo sapiens	141-144
16329037-4	2006	This immunohistochemical study was performed to analyze the distribution of three stress proteins (HSP25, HSP72, GRP75) in rat kidney and liver orally exposed to Al sulphate daily for 3 and 6 months.	aluminum sulfate	162-173	heat shock protein family B (small) member 1	Rattus norvegicus	99-104
16329037-4	2006	This immunohistochemical study was performed to analyze the distribution of three stress proteins (HSP25, HSP72, GRP75) in rat kidney and liver orally exposed to Al sulphate daily for 3 and 6 months.	aluminum sulfate	162-173	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	106-111
16329037-4	2006	This immunohistochemical study was performed to analyze the distribution of three stress proteins (HSP25, HSP72, GRP75) in rat kidney and liver orally exposed to Al sulphate daily for 3 and 6 months.	aluminum sulfate	162-173	heat shock protein family A (Hsp70) member 9	Rattus norvegicus	113-118
15780913-1	2005	Asymmetries in the manifold of spinning sidebands (ssbs) from the satellite transitions have been observed in variable-temperature 27Al MAS NMR spectra of alum (KAl(SO4)2.12H2O), recorded in the temperature range from -76 to 92 degrees C. The asymmetries decrease with increasing temperature and reflect the fact that the ssbs exhibit systematically different linewidths for different spectral regions of the manifold.	aluminum sulfate	155-159	anosmin 1	Homo sapiens	161-164
10955324-4	2000	The primary injection of the DR4/1 peptide in alum adjuvant was administered at one of 3 doses, 1.3, 4.0, and 13 mg, followed by up to 3 or 4 booster injections every 6 or 8 weeks at the same dose.	aluminum sulfate	46-50	major histocompatibility complex, class II, DR beta 4	Homo sapiens	29-34
15355467-13	2004	Alum, a commonly used adjuvant, enhances the release of IL-5 and may thereby enhance eosinophilopoiesis.	aluminum sulfate	0-4	interleukin 5	Mus musculus	56-60
11730850-3	2002	Immunization of IL-18-deficient mice with recombinant mIL-18 in the presence of CpG-oligodeoxynucleotides (CpG-ODN) and alum as adjuvant resulted in high anti-IL-18 serum titers.	aluminum sulfate	120-124	interleukin 18	Mus musculus	54-60
11394278-3	2001	The best pilot plant operational condition was obtained applying only 4.0 g/m3 (S*) with Vh around 18 cm.min-1 for treatment of water coagulated with a Al2(SO4)3 dosage of 40 mg.l-1.	aluminum sulfate	152-161	CD59 molecule (CD59 blood group)	Homo sapiens	105-110
10586035-1	1999	Previous studies demonstrate that aluminium hydroxide adjuvant (alum) produces increased Th1 responses in IL-4-deficient mice compared with wild-type animals, although the continued production of IL-5 by spleen cells from these mice also indicates that Th2 responses are induced.	aluminum sulfate	34-38	negative elongation factor complex member C/D, Th1l	Mus musculus	89-92
10841947-1	2000	To investigate the effect of antigen dose on immune response, C57BL/6 and BALB/c mice were sensitized with aluminum hydroxide gel (alum)-precipitated ovalbumin (OVA) then challenged with aerosolized OVA.	aluminum sulfate	107-111	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	150-159
10721010-4	2000	At a low concentration (10 microM), aluminum sulfate stimulated the level of immunoreactive Abeta and ubiquitin in NBP2 cells without changing the levels of the amyloid precursor protein (APP).	aluminum sulfate	36-52	amyloid beta precursor protein	Rattus norvegicus	92-97
11192297-1	2000	In the murine model of respiratory syncytial virus (RSV) infection, recombinant interleukin-12 (rIL-12) was previously demonstrated to be most effective as an adjuvant for fusion (F) protein-based vaccines after adsorption to alum adjuvant.	aluminum sulfate	226-239	interleukin 12B	Rattus norvegicus	96-102
10586035-2	1999	In the present study, we demonstrate that alum can induce Th2-associated IL-4 and IL-5 production in the absence of IL-4 signaling in mice deficient in either IL-4Ralpha or Stat6.	aluminum sulfate	42-46	signal transducer and activator of transcription 6	Mus musculus	173-178
10586035-1	1999	Previous studies demonstrate that aluminium hydroxide adjuvant (alum) produces increased Th1 responses in IL-4-deficient mice compared with wild-type animals, although the continued production of IL-5 by spleen cells from these mice also indicates that Th2 responses are induced.	aluminum sulfate	34-38	interleukin 4	Mus musculus	106-110
10586035-1	1999	Previous studies demonstrate that aluminium hydroxide adjuvant (alum) produces increased Th1 responses in IL-4-deficient mice compared with wild-type animals, although the continued production of IL-5 by spleen cells from these mice also indicates that Th2 responses are induced.	aluminum sulfate	34-38	heart and neural crest derivatives expressed 2	Mus musculus	253-256
10586035-2	1999	In the present study, we demonstrate that alum can induce Th2-associated IL-4 and IL-5 production in the absence of IL-4 signaling in mice deficient in either IL-4Ralpha or Stat6.	aluminum sulfate	42-46	heart and neural crest derivatives expressed 2	Mus musculus	58-61
10586035-2	1999	In the present study, we demonstrate that alum can induce Th2-associated IL-4 and IL-5 production in the absence of IL-4 signaling in mice deficient in either IL-4Ralpha or Stat6.	aluminum sulfate	42-46	interleukin 4	Mus musculus	73-77
10586035-2	1999	In the present study, we demonstrate that alum can induce Th2-associated IL-4 and IL-5 production in the absence of IL-4 signaling in mice deficient in either IL-4Ralpha or Stat6.	aluminum sulfate	42-46	interleukin 5	Mus musculus	82-86
10586035-2	1999	In the present study, we demonstrate that alum can induce Th2-associated IL-4 and IL-5 production in the absence of IL-4 signaling in mice deficient in either IL-4Ralpha or Stat6.	aluminum sulfate	42-46	interleukin 4 receptor, alpha	Mus musculus	159-169
8814247-6	1996	Similarly, increased production in vitro by splenocytes of the Th1 cytokine IFN-gamma, equivalent to that produced after inoculation with FCA/OVA, was only detected in IL-4 -/- mice inoculated with alum/OVA.	aluminum sulfate	198-202	negative elongation factor complex member C/D, Th1l	Mus musculus	63-66
10412555-1	1999	The purpose of the present study was to investigate the in vitro and in vivo effects of aluminum sulfate on delta-aminolevulinic acid dehydratase (ALA-D) activity from the brain, liver and kidney of adult mice (Swiss albine).	aluminum sulfate	88-104	aminolevulinate, delta-, dehydratase	Mus musculus	108-145
10412555-1	1999	The purpose of the present study was to investigate the in vitro and in vivo effects of aluminum sulfate on delta-aminolevulinic acid dehydratase (ALA-D) activity from the brain, liver and kidney of adult mice (Swiss albine).	aluminum sulfate	88-104	aminolevulinate, delta-, dehydratase	Mus musculus	147-152
10412555-4	1999	Exposure to aluminum sulfate in drinking water inhibited ALA-D activity in kidney (23.3 +/- 3.7%, mean +/- SEM, P < 0.05 compared to control), but enhanced it in liver (31.2 +/- 15.0%, mean +/- SEM, P < 0.05).	aluminum sulfate	12-28	aminolevulinate, delta-, dehydratase	Mus musculus	57-62
8814247-6	1996	Similarly, increased production in vitro by splenocytes of the Th1 cytokine IFN-gamma, equivalent to that produced after inoculation with FCA/OVA, was only detected in IL-4 -/- mice inoculated with alum/OVA.	aluminum sulfate	198-202	interferon gamma	Mus musculus	76-85
8814247-6	1996	Similarly, increased production in vitro by splenocytes of the Th1 cytokine IFN-gamma, equivalent to that produced after inoculation with FCA/OVA, was only detected in IL-4 -/- mice inoculated with alum/OVA.	aluminum sulfate	198-202	interleukin 4	Mus musculus	168-172
7821962-2	1994	In this study, mice were immunized subcutaneously with alum-precipitated keyhole limpet haemocyanin (KLH) in adjuvant to activate interleukin-4 (IL-4)-producing CD4+ T cells.	aluminum sulfate	55-59	interleukin 4	Mus musculus	130-143
8568620-8	1995	Especially, 0.16% ovalbumin-loaded PLGA microspheres having mean volume diameter of 3.5 microns exhibited the best immune responses with values greater than those obtained after inoculation with adjuvants such as complete Freund"s adjuvant or alum as positive control.	aluminum sulfate	243-247	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	18-27
7821962-2	1994	In this study, mice were immunized subcutaneously with alum-precipitated keyhole limpet haemocyanin (KLH) in adjuvant to activate interleukin-4 (IL-4)-producing CD4+ T cells.	aluminum sulfate	55-59	interleukin 4	Mus musculus	145-149
7821962-2	1994	In this study, mice were immunized subcutaneously with alum-precipitated keyhole limpet haemocyanin (KLH) in adjuvant to activate interleukin-4 (IL-4)-producing CD4+ T cells.	aluminum sulfate	55-59	CD4 antigen	Mus musculus	161-164
8384830-1	1993	Cytochrome c has been purified to homogeneity from alligator liver (Alligator mississipiensis) using aluminum sulfate precipitation, CM-cellulose and gel-filtration chromatography, and reverse-phase HPLC.	aluminum sulfate	101-117	cytochrome c	Alligator mississippiensis	0-12
34491470-9	2021	In addition, the secretion of IFN-gamma and IL-4 as well as the induction of lymphocyte proliferation in mice received the mixture of these proteins with Alum was considerably higher than other groups.	aluminum sulfate	154-158	interferon gamma	Mus musculus	30-39
8508053-4	1993	IgE responses were induced in BALB/c mice by intraperitoneal injection with benzylpenicilloyl-keyhole limpet hemocyanin (BPO-KLH) (10 micrograms) in aluminum hydroxide gel (Alum) on days 0, 21 and 42.	aluminum sulfate	173-177	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
33815376-13	2021	Conversely, alum containing preparations only demonstrated significant decreases in IgG in CD169 knockout mice.	aluminum sulfate	12-16	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	91-96
1665310-3	1991	The IgE antibody formation in BALB/c mice which had been immunized with dinitrophenylated ascaris extract (DNP.As) plus alum was inhibited dose-dependently by IPD-1151T given p.o.	aluminum sulfate	120-124	immunoglobulin heavy constant epsilon	Homo sapiens	4-7
33739899-8	2021	Elevated levels of interleukin-4, 6, interferon gamma and tumor necrosis factor alpha were also observed in Alum-only control mice compared with immunized mice.	aluminum sulfate	108-112	interleukin 4	Mus musculus	19-35
34491470-9	2021	In addition, the secretion of IFN-gamma and IL-4 as well as the induction of lymphocyte proliferation in mice received the mixture of these proteins with Alum was considerably higher than other groups.	aluminum sulfate	154-158	interleukin 4	Mus musculus	44-48
34706239-4	2021	Peli1-deficient mice have alleviated peritonitis induction by alum and display increased resistance to lipopolysaccharide (LPS) endotoxin shock, coupled with decreased serum concentration of IL-1beta.	aluminum sulfate	62-66	pellino 1	Mus musculus	0-5
34339771-6	2021	Formalin inactivated unadjuvanted vaccine elicited a balanced IgG1 type and IgG2a type antibody indicating a more balanced Th2/Th1 type immune response while alum formulated formalin inactivated antigen elicited significantly high IgG1 antibody in immunized sera and Th2 cytokines in mice splenocytes denoting Th2 type T cell immune response.	aluminum sulfate	158-162	LOC105243590	Mus musculus	231-235
34460865-10	2021	By stimulating the release of IL-33, alum induced Th2 immunity via IL-5 and IL-13 production in group 2 innate lymphoid cells (ILC2s) and increased MHC class II expression in antigen-presenting cells (APCs) in the lung.	aluminum sulfate	37-41	interleukin 33	Mus musculus	30-35
34387860-7	2021	Furthermore, an AKT agonist reduces NLRP3-dependent inflammation in two in vivo models of LPS-induced sepsis and Alum-induced peritonitis.	aluminum sulfate	113-117	AKT serine/threonine kinase 1	Homo sapiens	16-19
34460865-10	2021	By stimulating the release of IL-33, alum induced Th2 immunity via IL-5 and IL-13 production in group 2 innate lymphoid cells (ILC2s) and increased MHC class II expression in antigen-presenting cells (APCs) in the lung.	aluminum sulfate	37-41	interleukin 5	Mus musculus	67-71
34460865-10	2021	By stimulating the release of IL-33, alum induced Th2 immunity via IL-5 and IL-13 production in group 2 innate lymphoid cells (ILC2s) and increased MHC class II expression in antigen-presenting cells (APCs) in the lung.	aluminum sulfate	37-41	interleukin 13	Mus musculus	76-81
34266981-4	2021	The RBD+3M-052-alum adjuvanted vaccine promoted better RBD binding and effector antibodies, higher CoV-2 neutralizing antibodies, improved Th1 biased CD4+T cell reactions, and increased CD8+ T cell responses when compared to the alum-alone adjuvanted vaccine.	aluminum sulfate	15-19	CD4 molecule	Homo sapiens	150-153
34449792-4	2021	METHODS: Groups of 5 mice were injected intramuscularly with two doses of alum-adjuvanted HKU1 spike followed by SARS-CoV-2 spike; or the reciprocal regimen of SARS-Cov-2 spike followed by HKU1 spike.	aluminum sulfate	74-78	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	95-100
34362603-2	2021	In this study, TLR4 immunostimulatory molecules, Bacterial Enzymatic Combinatorial Chemistry (BECC) 438 and BECC470 were found to be superior IAV vaccine adjuvants when compared to the classic adjuvant alhydrogel (alum) and Phosphorylated Hexa-Acyl Disaccharide (PHAD), a synthetic TLR4 agonist.	aluminum sulfate	214-218	toll like receptor 4	Homo sapiens	15-19
34266981-4	2021	The RBD+3M-052-alum adjuvanted vaccine promoted better RBD binding and effector antibodies, higher CoV-2 neutralizing antibodies, improved Th1 biased CD4+T cell reactions, and increased CD8+ T cell responses when compared to the alum-alone adjuvanted vaccine.	aluminum sulfate	15-19	CD8a molecule	Homo sapiens	186-189
34152938-7	2022	Loss of BECN2 promoted alum-induced peritonitis, which could be rescued by the ablation of CASP1 in Becn2-deficient mice.	aluminum sulfate	23-27	beclin 2	Mus musculus	8-13
35406645-5	2022	In contrast, PPIL4-20/alum treatment induced robust IL-10 and IL-4 responses, which spread to other autoantigens and increased the frequency of splenic IL-10-secreting Treg and Tr-1-like cells, without boosting IFNgamma responses to ss-cell autoantigens.	aluminum sulfate	22-26	peptidylprolyl isomerase (cyclophilin)-like 4	Mus musculus	13-21
34075153-3	2021	Here, we redesigned the S100A9 vaccine for the common sequence in both humans and monkeys and examined its effects in cynomolgus monkeys with Alum adjuvant.	aluminum sulfate	142-155	S100 calcium binding protein A9	Homo sapiens	24-30
34075153-5	2021	When this peptide vaccine was intradermally injected into 4 cynomolgus monkeys with Alum, the antibody against human S100A9 was successfully produced.	aluminum sulfate	84-88	S100 calcium binding protein A9	Homo sapiens	117-123
35606855-8	2022	RESULTS: Aged mice had lower antigen trafficking and DC activation than younger mice (6-weeks), which was ameliorated by PGA/Alum with increased antigen uptake and DC activation leading to improved antigen-specific IFN-gamma+CD8+ T lymphocyte frequencies higher in the vaccinated aged mice, to a similar extent as PGA/Alum adjuvanted vaccine-immunized young mice.	aluminum sulfate	125-129	interferon gamma	Mus musculus	215-224
35606855-8	2022	RESULTS: Aged mice had lower antigen trafficking and DC activation than younger mice (6-weeks), which was ameliorated by PGA/Alum with increased antigen uptake and DC activation leading to improved antigen-specific IFN-gamma+CD8+ T lymphocyte frequencies higher in the vaccinated aged mice, to a similar extent as PGA/Alum adjuvanted vaccine-immunized young mice.	aluminum sulfate	318-322	interferon gamma	Mus musculus	215-224
35440091-4	2022	A germline PKD3-knockout mouse line was analyzed for its immune response to OVA/alum intraperitoneal immunization.	aluminum sulfate	80-84	protein kinase D3	Mus musculus	11-15
35406645-5	2022	In contrast, PPIL4-20/alum treatment induced robust IL-10 and IL-4 responses, which spread to other autoantigens and increased the frequency of splenic IL-10-secreting Treg and Tr-1-like cells, without boosting IFNgamma responses to ss-cell autoantigens.	aluminum sulfate	22-26	interleukin 10	Mus musculus	52-57
35406645-5	2022	In contrast, PPIL4-20/alum treatment induced robust IL-10 and IL-4 responses, which spread to other autoantigens and increased the frequency of splenic IL-10-secreting Treg and Tr-1-like cells, without boosting IFNgamma responses to ss-cell autoantigens.	aluminum sulfate	22-26	interleukin 4	Mus musculus	62-66
35406645-5	2022	In contrast, PPIL4-20/alum treatment induced robust IL-10 and IL-4 responses, which spread to other autoantigens and increased the frequency of splenic IL-10-secreting Treg and Tr-1-like cells, without boosting IFNgamma responses to ss-cell autoantigens.	aluminum sulfate	22-26	interleukin 10	Mus musculus	152-157
35406645-5	2022	In contrast, PPIL4-20/alum treatment induced robust IL-10 and IL-4 responses, which spread to other autoantigens and increased the frequency of splenic IL-10-secreting Treg and Tr-1-like cells, without boosting IFNgamma responses to ss-cell autoantigens.	aluminum sulfate	22-26	interferon gamma	Mus musculus	211-219
35406645-6	2022	In newly diabetic NOD mice, PPIL4-20, but not insulin B-chain9-23 administered intraperitoneally (with alum) or intradermally (as soluble antigen) supplemented with oral GABA induced long-term disease remission.	aluminum sulfate	103-107	peptidylprolyl isomerase (cyclophilin)-like 4	Mus musculus	28-36
3708909-1	1986	A monoclonal IgE antibody directed against bovine milk beta-lactoglobulin (beta-LG) was produced by fusion of NSI myeloma cells with spleen cells of Balb/c mice immunized with alum-precipitated beta-LG.	aluminum sulfate	176-180	beta-lactoglobulin	Bos taurus	55-73
2776217-0	1989	The polyclonal and antigen-specific IgE and IgG subclass response of mice injected with ovalbumin in alum or complete Freund"s adjuvant.	aluminum sulfate	101-105	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	88-97
35296091-7	2022	Additionally, U-Omp19+alum formulation induced RBD-specific Th1 and CD8+ T-cell responses in spleens and lungs.	aluminum sulfate	22-26	CD8a molecule	Homo sapiens	68-71
35110683-5	2022	gp78 or Insig-1 deficiency in myeloid cells led to exacerbated NLRP3 inflammasome-dependent inflammation in vivo, including lipopolysaccharide-induced systemic inflammation and alum-induced peritonitis.	aluminum sulfate	177-181	autocrine motility factor receptor	Homo sapiens	0-4
35110683-5	2022	gp78 or Insig-1 deficiency in myeloid cells led to exacerbated NLRP3 inflammasome-dependent inflammation in vivo, including lipopolysaccharide-induced systemic inflammation and alum-induced peritonitis.	aluminum sulfate	177-181	NLR family pyrin domain containing 3	Homo sapiens	63-68
34998855-3	2022	Balb/c mice were sensitized with intraperitoneal injection of OVA (Ovalbumin; 100 mug of OVA with alum) from day 1 to 8 and exposed to LPS with 1% OVA aerosol from day 9 to 15.	aluminum sulfate	98-102	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	89-92
34997099-3	2022	The morphology of alpha-HH was adjusted by adding different doses of Maleic acid and Aluminium sulfate.	aluminum sulfate	85-102	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-26
34997099-6	2022	Fixing the amount of aluminium sulfate at 0.2 wt%, the reaction temperature at 140  C, and the reaction time at 120 min, the average length/diameter ratio of alpha-HH crystals decreased from 7.2 to 0.6 as the amount of Maleic acid increased from 0 to 0.17 wt%.	aluminum sulfate	21-38	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	158-166
2937840-3	1986	Immunization of BDF1 mice with aluminum hydroxide gel (alum)-absorbed dinitrophenyl derivatives of ovalbumin (DNP-OA) resulted in persistent IgE and IgG antibody formation.	aluminum sulfate	31-35	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	99-108
2937840-9	1986	Transfer of a Lyt-1+ cell-depleted fraction of the OA-primed, GIF-treated mouse spleen cells into naive syngeneic animals resulted in suppression of the primary anti-DNP IgE antibody response of the recipients to alum-absorbed DNP-OA, but failed to affect the anti-DNP antibody response to DNP-keyhole limpet hemocyanin.	aluminum sulfate	213-217	CD5 antigen	Mus musculus	14-19
2937840-9	1986	Transfer of a Lyt-1+ cell-depleted fraction of the OA-primed, GIF-treated mouse spleen cells into naive syngeneic animals resulted in suppression of the primary anti-DNP IgE antibody response of the recipients to alum-absorbed DNP-OA, but failed to affect the anti-DNP antibody response to DNP-keyhole limpet hemocyanin.	aluminum sulfate	213-217	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	62-65
3708909-1	1986	A monoclonal IgE antibody directed against bovine milk beta-lactoglobulin (beta-LG) was produced by fusion of NSI myeloma cells with spleen cells of Balb/c mice immunized with alum-precipitated beta-LG.	aluminum sulfate	176-180	beta-lactoglobulin	Bos taurus	75-82
2944845-4	1986	The treatment of normal spleen cells with SBF resulted in a 50-70% decrease in anti-dinitrophenyl (DNP) antibody production when the cells were transferred into X-ray-irradiated mice along with alum-precipitated dinitrophenyl-conjugated keyhole limpet hemocyanin (DNP-KLH).	aluminum sulfate	194-198	zinc finger protein 143	Mus musculus	42-45
2995573-2	1985	Control mice received injections of alum-precipitated 1% bovine serum albumin (BSA).	aluminum sulfate	36-40	albumin	Mus musculus	64-77
6724781-0	1984	Topical aluminum sulfate for fire ant stings.	aluminum sulfate	8-24	solute carrier family 25 member 6	Homo sapiens	34-37
1276263-2	1976	Treatment of ROS by alum caused a complete disappearance of non-rhodopsin proteins and the appearance of slow migrating band (component II).	aluminum sulfate	20-24	rhodopsin	Bos taurus	64-73
19871668-3	1947	Two horses were injected subcutaneously with alum-precipitated rabbit serum albumin.	aluminum sulfate	45-49	albumin	Equus caballus	70-83
172116-4	1975	The phosphorylation reaction apparently requires a specific conformation of the rhodopsin molecule since it is abolished by heat denaturation of rhodopsin, and it is greatly reduced or abolished by treatment of the visual pigment protein with potassium alum after the rhodopsin has been "bleached" by light.	aluminum sulfate	243-257	rhodopsin	Bos taurus	80-89
172116-4	1975	The phosphorylation reaction apparently requires a specific conformation of the rhodopsin molecule since it is abolished by heat denaturation of rhodopsin, and it is greatly reduced or abolished by treatment of the visual pigment protein with potassium alum after the rhodopsin has been "bleached" by light.	aluminum sulfate	243-257	rhodopsin	Bos taurus	145-154
172116-4	1975	The phosphorylation reaction apparently requires a specific conformation of the rhodopsin molecule since it is abolished by heat denaturation of rhodopsin, and it is greatly reduced or abolished by treatment of the visual pigment protein with potassium alum after the rhodopsin has been "bleached" by light.	aluminum sulfate	243-257	rhodopsin	Bos taurus	145-154
6061222-0	1967	[Decontamination of river water from Sr89 and Ce-141 by domestic clays and aluminum sulfate].	aluminum sulfate	75-91	LUC7 like	Homo sapiens	37-41
14264273-4	1965	Injections of thyroglobulin coupled to the diazonium derivatives of arsanilic acid and sulfanilic acid were effective when given in either soluble form or incorporated into incomplete Freund"s adjuvant) while injections of the same preparations precipitated by alum had relatively little effect on production of antibody or induction of lesions.	aluminum sulfate	261-265	LOW QUALITY PROTEIN: thyroglobulin	Oryctolagus cuniculus	14-27
33873199-4	2021	RBD-NP immunization with AS03, CpG1018-Alum, AS37 or Alum induced substantial nAb and CD4 T cell responses, and conferred protection against SARS-CoV-2 infection in the pharynges, nares and bronchoalveolar lavage.	aluminum sulfate	39-43	CD4 molecule	Homo sapiens	86-89
33263336-8	2021	Moreover, the depletion of CD4+ T, CD8+ T, and NK cells reduced the survival rate and efficacy of the PGA/alum-adjuvanted chimeric protein.	aluminum sulfate	106-110	CD4 molecule	Homo sapiens	27-30
32901127-6	2021	RKIP-deficient mice showed increased sensitivity to Alum-induced peritonitis and Salmonella typhimurium-induced inflammation, indicating that RKIP inhibits NLRP3 and NLRC4 inflammasome activation in vivo.	aluminum sulfate	52-56	phosphatidylethanolamine binding protein 1	Mus musculus	0-4
32901127-6	2021	RKIP-deficient mice showed increased sensitivity to Alum-induced peritonitis and Salmonella typhimurium-induced inflammation, indicating that RKIP inhibits NLRP3 and NLRC4 inflammasome activation in vivo.	aluminum sulfate	52-56	phosphatidylethanolamine binding protein 1	Homo sapiens	142-146
32901127-6	2021	RKIP-deficient mice showed increased sensitivity to Alum-induced peritonitis and Salmonella typhimurium-induced inflammation, indicating that RKIP inhibits NLRP3 and NLRC4 inflammasome activation in vivo.	aluminum sulfate	52-56	NLR family pyrin domain containing 3	Homo sapiens	156-161
32901127-6	2021	RKIP-deficient mice showed increased sensitivity to Alum-induced peritonitis and Salmonella typhimurium-induced inflammation, indicating that RKIP inhibits NLRP3 and NLRC4 inflammasome activation in vivo.	aluminum sulfate	52-56	NLR family CARD domain containing 4	Homo sapiens	166-171
33797035-8	2021	Additionally, subcutaneous immunization of mice with a single dose of the ovalbumin-loaded nanoparticles led to induced T cell proliferation and antibody responses, comparable to those achieved with alum-adsorbed ovalbumin.	aluminum sulfate	199-203	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	74-83
33797035-8	2021	Additionally, subcutaneous immunization of mice with a single dose of the ovalbumin-loaded nanoparticles led to induced T cell proliferation and antibody responses, comparable to those achieved with alum-adsorbed ovalbumin.	aluminum sulfate	199-203	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	213-222
32594359-0	2021	Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model.	aluminum sulfate	21-37	matrix metallopeptidase 2	Rattus norvegicus	61-90
32594359-6	2021	PR administration (100 and 200 mg/kg) alone or with alum (35 and 75 mg/kg) significantly decreased myometrium collagen contents and the gene expression and protein concentration of MMP-2 and 9 compared with UL and UL + Coi subgroups (P   0.05).	aluminum sulfate	52-56	matrix metallopeptidase 2	Rattus norvegicus	181-192
32594359-6	2021	PR administration (100 and 200 mg/kg) alone or with alum (35 and 75 mg/kg) significantly decreased myometrium collagen contents and the gene expression and protein concentration of MMP-2 and 9 compared with UL and UL + Coi subgroups (P   0.05).	aluminum sulfate	52-56	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	219-222
32594359-7	2021	Alum (75 mg/kg) with PR (200 mg/kg) could improve UL features and reduce MMP-2 and 9 gene expression.	aluminum sulfate	0-4	matrix metallopeptidase 2	Rattus norvegicus	73-84
33263336-8	2021	Moreover, the depletion of CD4+ T, CD8+ T, and NK cells reduced the survival rate and efficacy of the PGA/alum-adjuvanted chimeric protein.	aluminum sulfate	106-110	CD8a molecule	Homo sapiens	35-38
31866999-7	2019	In the absence of VDR, caspase-1 activation and IL-1beta release are increased in response to LPS-induced inflammation or alum-induced peritoneal inflammation, indicating that VDR is a negative regulator of NLRP3 inflammasome activation in vivo.	aluminum sulfate	122-126	caspase 1	Homo sapiens	23-32
33315350-9	2020	According to the paired samples analyses of the comparison between hospitalization and discharge, CRP levels significantly drops in the Alum Group (from 54.09 to 27, P = 0.001) but not in the Control Group.	aluminum sulfate	136-140	C-reactive protein	Homo sapiens	98-101
32602465-8	2020	CONCLUSION: Our alum free mono-component monovalent recombinant fusion protein (LLO-PTS1) could bear the capacity to stimulate the release of IFN-gamma similar to wP and aP vaccines in the mouse model.	aluminum sulfate	16-20	interferon gamma	Mus musculus	142-151
32582954-9	2021	RESULTS: Our results showed that the activation of NLRP3 inflammasome in macrophage and alum-induced peritonitis was inhibited by IL-37d.	aluminum sulfate	88-92	NLR family, pyrin domain containing 3	Mus musculus	51-56
33097834-7	2021	Consistent with these observations, compared to wild-type mice, Usp19-/- mice had decreased M2-like macrophage polarization and increased interleukin-1beta secretion, in response to alum and chitin injections.	aluminum sulfate	182-186	ubiquitin specific peptidase 19	Mus musculus	64-69
32802401-1	2020	Aim: Double-blind placebo-controlled intervention using glutamic acid decarboxylase (GAD)-alum, vitamin D and Ibuprofen in recent onset Type I diabetes (T1D).	aluminum sulfate	90-94	glutamate decarboxylase 1	Homo sapiens	56-83
32802401-1	2020	Aim: Double-blind placebo-controlled intervention using glutamic acid decarboxylase (GAD)-alum, vitamin D and Ibuprofen in recent onset Type I diabetes (T1D).	aluminum sulfate	90-94	glutamate decarboxylase 1	Homo sapiens	85-88
32802401-3	2020	20 mug GAD-alum; as A but placebo instead of Ibuprofen; as B but 40 mug GAD-alum D15, 45; placebo.	aluminum sulfate	11-15	glutamate decarboxylase 1	Homo sapiens	7-10
32561559-6	2020	In contrast, adjuvanting Env with alum or GLA in NP induced significantly lower (~<100-fold) LLPC and antibody responses.	aluminum sulfate	34-38	endogenous retrovirus group V member 1 Env polyprotein	Macaca mulatta	25-28
32595634-7	2020	The vaccine potential of LcrV-HSP70 fusion protein was evaluated in formulation with alum.	aluminum sulfate	85-89	Yop secretion and targeting control protein	Yersinia pestis	25-29
31518804-4	2020	It was hypothesized that graphitic carbon nitride derived from melamine oxidizes As(III) to As(V) and pyrolyzed alum sludge provides strong adsorption sites for the oxidized As(V).	aluminum sulfate	112-116	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	174-179
31866999-7	2019	In the absence of VDR, caspase-1 activation and IL-1beta release are increased in response to LPS-induced inflammation or alum-induced peritoneal inflammation, indicating that VDR is a negative regulator of NLRP3 inflammasome activation in vivo.	aluminum sulfate	122-126	interleukin 1 alpha	Homo sapiens	48-56
31866999-7	2019	In the absence of VDR, caspase-1 activation and IL-1beta release are increased in response to LPS-induced inflammation or alum-induced peritoneal inflammation, indicating that VDR is a negative regulator of NLRP3 inflammasome activation in vivo.	aluminum sulfate	122-126	vitamin D receptor	Homo sapiens	176-179
31866999-7	2019	In the absence of VDR, caspase-1 activation and IL-1beta release are increased in response to LPS-induced inflammation or alum-induced peritoneal inflammation, indicating that VDR is a negative regulator of NLRP3 inflammasome activation in vivo.	aluminum sulfate	122-126	NLR family pyrin domain containing 3	Homo sapiens	207-212
29349774-10	2018	Overall, these findings indicate that injection of alum promotes IL-10, which can block Th1 responses and may explain the poor efficacy of alum as an adjuvant for inducing protective Th1 immunity.	aluminum sulfate	51-55	interleukin 10	Mus musculus	65-70
31156652-3	2019	Here, our results suggest that conventional vaccine strategies are unable to establish a measurable antigen (Ag)-specific memory cell pool in stomach; in comparison, gastric subserous injection of mice with micro-dose of Alum-based H. pylori vaccine can induce a pool of local CD4+ Trm cells.	aluminum sulfate	221-225	CD4 molecule	Homo sapiens	277-280
30926296-5	2019	The IL-33 treated mice had higher plasma IgG Ab avidity, breadth, and durability after DNA and protein co-immunization with alum adjuvant as compared to MPLA and alum only treated mice.	aluminum sulfate	124-137	interleukin 33	Mus musculus	4-9
30447395-8	2019	Active immunization of Hc-CoaR6 with alum plus CpG showed protective effects in a peritonitis model induced by two S. aureus strains with different coagulase types.	aluminum sulfate	37-41	AT695_RS02730	Staphylococcus aureus	148-157
30405178-3	2018	The alum-adjuvanted PIZV candidates were highly immunogenic in both CD-1 and AG129 mice after a 2-dose immunization.	aluminum sulfate	4-8	CD1 antigen complex	Mus musculus	68-72
30257198-3	2018	NK cells restrict follicular helper T cell (TFH) and GC B cell frequencies and titers of antigen-specific immunoglobulin after administration of alum-adjuvanted hapten-protein conjugate vaccines.	aluminum sulfate	145-149	natriuretic peptide receptor 2	Homo sapiens	53-57
29171140-2	2018	We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity.	aluminum sulfate	55-59	glutamate-ammonia ligase	Homo sapiens	71-94
29171140-2	2018	We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity.	aluminum sulfate	55-59	glutamate decarboxylase 1	Homo sapiens	96-99
30926296-5	2019	The IL-33 treated mice had higher plasma IgG Ab avidity, breadth, and durability after DNA and protein co-immunization with alum adjuvant as compared to MPLA and alum only treated mice.	aluminum sulfate	124-128	interleukin 33	Mus musculus	4-9
30551986-5	2019	In contrast, immunization of naive or previously HSV-2-infected guinea pigs with gC2 subunit antigen administered with CpG and alum as adjuvants produces antibodies that block domains involved in immune evasion.	aluminum sulfate	127-131	solute carrier family 25 member 18	Homo sapiens	81-84
29349774-10	2018	Overall, these findings indicate that injection of alum promotes IL-10, which can block Th1 responses and may explain the poor efficacy of alum as an adjuvant for inducing protective Th1 immunity.	aluminum sulfate	51-55	negative elongation factor complex member C/D, Th1l	Mus musculus	88-91
29349774-10	2018	Overall, these findings indicate that injection of alum promotes IL-10, which can block Th1 responses and may explain the poor efficacy of alum as an adjuvant for inducing protective Th1 immunity.	aluminum sulfate	51-55	negative elongation factor complex member C/D, Th1l	Mus musculus	183-186
30134814-4	2018	RESULT: EP dose-dependently inhibited the ATP-, nigericin-, alum-, and silica-induced caspase-1 activation and HMGB1 release in mouse macrophages.	aluminum sulfate	60-64	caspase 1	Mus musculus	86-95
28799242-5	2018	In mice with alum-induced peritonitis, blockade of Tim-3 exacerbates peritonitis by overcoming the inhibitory effect of Tim-3 on NLRP3 inflammasome activation, while transgenic expression of Tim-3 attenuates inflammation by inhibiting NLRP3 inflammasome activation.	aluminum sulfate	13-17	hepatitis A virus cellular receptor 2	Mus musculus	51-56
28130898-4	2017	The optimum pHi was 7 for TiCl4, 5.5 for Ti(SO4)2, and 7 for Al2(SO4)3.	aluminum sulfate	61-70	glucose-6-phosphate isomerase	Homo sapiens	12-15
29321759-5	2017	Interestingly, the application of known pro-inflammatory stressors, such as the Abeta42 peptide and the metal-neurotoxin aluminum sulfate, to human neuronal-glial cells in primary culture resulted in a significant decrease in the expression of Shank3.	aluminum sulfate	121-137	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	244-250
28993770-4	2017	In contrast to non-adjuvanted or alum-adjuvanted formulations, antibodies induced in mice immunized with LT or LTB showed enhanced virus-neutralization effects that were not ascribed to a subclass shift or antigen affinity.	aluminum sulfate	33-37	lymphotoxin B	Mus musculus	111-114
29263862-7	2017	Further studies in PAD4-/- mice confirmed a significant role for neutrophil extracellular trap formation in the adjuvant activity of Alum.	aluminum sulfate	133-137	MMTV LTR integration site 4	Mus musculus	19-23
26673671-9	2016	H36.12J cell TNFalpha expression was shown to be metal-specific by the induction of significantly more TNFalpha when exposed to Be than when exposed to aluminum sulfate, or nickel (II) chloride, but not when exposed to cobalt (II) chloride.	aluminum sulfate	152-168	tumor necrosis factor	Mus musculus	13-21
27717764-3	2017	This study investigated the in vivo and in vitro effects of aluminium sulfate on the activity of enzymes from Nile tilapia (Oreochromis niloticus): brain acetylcholinesterase (AChE), muscle cholinesterases (AChE-like and BChE-like activities), pepsin, trypsin, chymotrypsin and amylase.	aluminum sulfate	60-77	acetylcholinesterase	Oreochromis niloticus	154-174
27704166-4	2017	RESULTS: We estimate that there is a 98% probability that 20 mug GAD with alum administered twice yields a positive biological effect.	aluminum sulfate	74-78	glutamate decarboxylase 1	Homo sapiens	65-68
27745952-3	2016	Alum-adjuvanted vaccines induce local inflammatory nodules at injection sites, and the systemic and local production of the inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha, has been reported to occur three hours after vaccinations.	aluminum sulfate	0-4	interleukin 1 beta	Homo sapiens	148-156
27745952-3	2016	Alum-adjuvanted vaccines induce local inflammatory nodules at injection sites, and the systemic and local production of the inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha, has been reported to occur three hours after vaccinations.	aluminum sulfate	0-4	interleukin 6	Homo sapiens	158-162
27745952-3	2016	Alum-adjuvanted vaccines induce local inflammatory nodules at injection sites, and the systemic and local production of the inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha, has been reported to occur three hours after vaccinations.	aluminum sulfate	0-4	tumor necrosis factor	Homo sapiens	168-177
26265215-5	2015	In the current pilot study we examined (i) CRP levels in human serum obtained from AD and age-matched control patients; and (ii) analyzed the effects of nanomolar aluminum sulfate on CRP expression in primary hBMECs.	aluminum sulfate	163-179	C-reactive protein	Homo sapiens	183-186
27108091-8	2016	RESULTS: We demonstrate that exposure to silica, alum and polystyrene particulates induces IL-1beta release from macrophages, through lysosomal destabilization.	aluminum sulfate	49-53	interleukin 1 beta	Mus musculus	91-99
26403975-10	2016	Immunization of mice with HIV-1 p24-Nef fusion peptide formulated in Naloxone/alum mixture significantly increased lymphocyte proliferation and shifted cytokine responses toward Th1 profile compared to all other groups.	aluminum sulfate	78-82	transmembrane p24 trafficking protein 2	Homo sapiens	32-35
26403975-10	2016	Immunization of mice with HIV-1 p24-Nef fusion peptide formulated in Naloxone/alum mixture significantly increased lymphocyte proliferation and shifted cytokine responses toward Th1 profile compared to all other groups.	aluminum sulfate	78-82	Nef	Human immunodeficiency virus 1	36-39
26602597-2	2015	Here we show that Alum-induced inflammasome activation in vitro and in vivo is mediated by the G protein-coupled receptor GPRC6A.	aluminum sulfate	18-22	G protein-coupled receptor, family C, group 6, member A	Mus musculus	122-128
26091541-6	2015	Microglia were able to produce IL-1beta in response to different classical inflammasome activators, such as ATP, Nigericin or Alum.	aluminum sulfate	126-130	interleukin 1 beta	Mus musculus	31-39
26384437-9	2015	On the basis of previous reports showing alum neurotoxic effects in CD1 mice, an additional experiment was done, and showed early brain translocation at day 45 of alum injected subcutaneously at 200 mug Al/kg.	aluminum sulfate	41-45	CD1 antigen complex	Mus musculus	68-71
25424319-0	2015	Aldehyde modification and alum coadjuvancy enhance anti-TNF-alpha autovaccination and mitigate arthritis in rat.	aluminum sulfate	26-30	tumor necrosis factor	Rattus norvegicus	56-65
24575938-7	2014	Moreover, immunization of BALB/c mice with different doses of Eq1 formulated either in Alum or Freund"s incomplete adjuvant elicited both humoral- and cellular-specific immune responses.	aluminum sulfate	87-91	dermatopontin	Mus musculus	62-65
25271165-8	2014	Furthermore, GPSM3-null mice have enhanced serum and peritoneal IL-1beta production following Alum-induced peritonitis.	aluminum sulfate	94-98	G-protein signalling modulator 3 (AGS3-like, C. elegans)	Mus musculus	13-18
25271165-8	2014	Furthermore, GPSM3-null mice have enhanced serum and peritoneal IL-1beta production following Alum-induced peritonitis.	aluminum sulfate	94-98	interleukin 1 beta	Mus musculus	64-72
25531528-7	2015	Moreover, when adjuvanted with alum, but not with liposomal MPLA, GNE-FliC was found to be better than our benchmark GNE-KLH.	aluminum sulfate	31-35	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	66-69
25012630-1	2014	OBJECTIVE: To investigate the effects of potassium alum (Alunite) on smooth muscle contraction and phosphorylation of myosin light chain by myosin light chain kinase (MLCK) and to try to find out the clue of its mechanism.	aluminum sulfate	41-55	myosin, heavy chain 15	Gallus gallus	118-124
25012630-1	2014	OBJECTIVE: To investigate the effects of potassium alum (Alunite) on smooth muscle contraction and phosphorylation of myosin light chain by myosin light chain kinase (MLCK) and to try to find out the clue of its mechanism.	aluminum sulfate	41-55	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	140-165
25012630-1	2014	OBJECTIVE: To investigate the effects of potassium alum (Alunite) on smooth muscle contraction and phosphorylation of myosin light chain by myosin light chain kinase (MLCK) and to try to find out the clue of its mechanism.	aluminum sulfate	41-55	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	167-171
24711582-3	2014	After alum-adjuvanted immunization, antigen-specific bone marrow plasma cells deficient in the transcription factor ZBTB20 failed to accumulate over time, leading to a progressive loss of antibody production relative to wild-type controls.	aluminum sulfate	6-10	zinc finger and BTB domain containing 20	Homo sapiens	116-122
24021662-4	2014	Active immunization was optimized using ALUM as an adjuvant to stimulate production of anti-SDPM1 and anti-Abeta amyloid antibodies.	aluminum sulfate	40-44	amyloid beta (A4) precursor protein	Mus musculus	107-112
23888349-2	2014	The TiO2 photocatalyst used in this study was synthesized via sol-gel method and doped with potassium aluminum sulfate (KAl(SO4)2) and sodium aluminate (NaAlO2).	aluminum sulfate	92-118	anosmin 1	Homo sapiens	120-123
24798340-9	2014	Nrf2(-/-) mice showed a dramatic decrease in immune cell recruitment and IL-1beta generation in alum-induced peritonitis, which is a typical IL-1 signaling-dependent inflammation animal model.	aluminum sulfate	96-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
24798340-9	2014	Nrf2(-/-) mice showed a dramatic decrease in immune cell recruitment and IL-1beta generation in alum-induced peritonitis, which is a typical IL-1 signaling-dependent inflammation animal model.	aluminum sulfate	96-100	interleukin 1 beta	Mus musculus	73-81