PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23536832-0	2013	Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation.	steviol	0-7	CF transmembrane conductance regulator	Canis lupus familiaris	61-65
24518257-8	2014	In addition, steviol suppressed CFTR and mTOR/S6K expression in renal cyst-lining epithelial cells.	steviol	13-20	cystic fibrosis transmembrane conductance regulator	Mus musculus	32-36
24518257-8	2014	In addition, steviol suppressed CFTR and mTOR/S6K expression in renal cyst-lining epithelial cells.	steviol	13-20	mechanistic target of rapamycin kinase	Mus musculus	41-45
24518257-8	2014	In addition, steviol suppressed CFTR and mTOR/S6K expression in renal cyst-lining epithelial cells.	steviol	13-20	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	46-49
24518257-10	2014	Our findings indicate that steviol slows cyst progression in ADPKD mouse model, in part, through the activation of AMPK which subsequently inhibits CFTR chloride channel expression and inhibits renal epithelial cell proliferation via mTOR/S6K pathway.	steviol	27-34	cystic fibrosis transmembrane conductance regulator	Mus musculus	148-152
24518257-10	2014	Our findings indicate that steviol slows cyst progression in ADPKD mouse model, in part, through the activation of AMPK which subsequently inhibits CFTR chloride channel expression and inhibits renal epithelial cell proliferation via mTOR/S6K pathway.	steviol	27-34	mechanistic target of rapamycin kinase	Mus musculus	234-238
24518257-10	2014	Our findings indicate that steviol slows cyst progression in ADPKD mouse model, in part, through the activation of AMPK which subsequently inhibits CFTR chloride channel expression and inhibits renal epithelial cell proliferation via mTOR/S6K pathway.	steviol	27-34	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	239-242
24296138-7	2014	Taken together, the identification of the involvement of UGT2B7 in steviol glucuronidation would provide a mechanistic basis for the evaluation of the interaction between steviol and diclofenac.	steviol	67-74	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	57-63
24296138-7	2014	Taken together, the identification of the involvement of UGT2B7 in steviol glucuronidation would provide a mechanistic basis for the evaluation of the interaction between steviol and diclofenac.	steviol	171-178	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	57-63
24009336-8	2013	Intriguingly, the recombinant CYP714A2 protein catalyzed the conversion of ent-kaurenoic acid into steviol (ent-13-hydroxy kaurenoic acid).	steviol	99-106	cytochrome P450, family 714, subfamily A, polypeptide 2	Arabidopsis thaliana	30-38
26407946-9	2015	RESULTS: The absolute and relative quantitation of GLUT4 gene by qPCR showed the activation of GLUT4 transcript at lower concentration of steviol (1 microM) and higher concentration of stevioside (100 microM) in both L6 myotubes and 3T3-L1 adipocytes.	steviol	138-145	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	51-56
26407946-9	2015	RESULTS: The absolute and relative quantitation of GLUT4 gene by qPCR showed the activation of GLUT4 transcript at lower concentration of steviol (1 microM) and higher concentration of stevioside (100 microM) in both L6 myotubes and 3T3-L1 adipocytes.	steviol	138-145	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	95-100
26407946-10	2015	The increased level of glut4 protein and the glucose uptake in both the cell lines using the same concentration of steviol and stevioside further supports the qPCR data.	steviol	115-122	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	23-28
26407946-11	2015	The copy number and the expression level of GLUT4 gene, the amount of GLUT4 protein and the glucose uptake efficacy support the insulinomimetic effect of steviol and stevioside.	steviol	154-161	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	44-49
26407946-11	2015	The copy number and the expression level of GLUT4 gene, the amount of GLUT4 protein and the glucose uptake efficacy support the insulinomimetic effect of steviol and stevioside.	steviol	154-161	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	70-75
23794454-6	2013	In addition, stevioside and steviol showed immunomodulatory effects on IkappaBalpha activation and nuclear factor kappa B (NF-kappaB) suppression in western blotting.	steviol	28-35	NFKB inhibitor alpha	Homo sapiens	71-83
23794454-6	2013	In addition, stevioside and steviol showed immunomodulatory effects on IkappaBalpha activation and nuclear factor kappa B (NF-kappaB) suppression in western blotting.	steviol	28-35	nuclear factor kappa B subunit 1	Homo sapiens	99-121
23794454-6	2013	In addition, stevioside and steviol showed immunomodulatory effects on IkappaBalpha activation and nuclear factor kappa B (NF-kappaB) suppression in western blotting.	steviol	28-35	nuclear factor kappa B subunit 1	Homo sapiens	123-132
23794454-7	2013	CONCLUSION: Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IkappaBalpha/NF-kappaB signalling pathway.	steviol	27-34	NFKB inhibitor alpha	Homo sapiens	137-149
23794454-7	2013	CONCLUSION: Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IkappaBalpha/NF-kappaB signalling pathway.	steviol	27-34	nuclear factor kappa B subunit 1	Homo sapiens	150-159
23536832-0	2013	Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation.	steviol	0-7	CF transmembrane conductance regulator	Canis lupus familiaris	117-121
23536832-7	2013	Prolonged treatment (24 h) with steviol (100 microM) also strongly inhibited forskolin-stimulated apical chloride current, in part by reducing CFTR protein expression in MDCK cells.	steviol	32-39	CF transmembrane conductance regulator	Canis lupus familiaris	143-147
23536832-8	2013	Interestingly, proteasome inhibitor, MG-132, abolished the effect of steviol on CFTR protein expression.	steviol	69-76	CF transmembrane conductance regulator	Canis lupus familiaris	80-84
23536832-9	2013	Immunofluorescence studies demonstrated that prolonged treatment (24 h) with steviol (100 microM) markedly reduced CFTR expression at the plasma membrane.	steviol	77-84	CF transmembrane conductance regulator	Canis lupus familiaris	115-119
34023281-1	2021	The interaction of the steviol and its glycosides (SG), steviolbioside, and rebaudioside A, with bovine serum albumin (BSA) was studied by absorption and fluorescence spectroscopy techniques alongside molecular docking.	steviol	23-30	albumin	Homo sapiens	104-117
18433103-6	2008	However, steviol (0.01-0.2 mM) significantly suppressed TNF-alpha-induced IL-8 release in all three cell lines.	steviol	9-16	tumor necrosis factor	Homo sapiens	56-65
18433103-6	2008	However, steviol (0.01-0.2 mM) significantly suppressed TNF-alpha-induced IL-8 release in all three cell lines.	steviol	9-16	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
18433103-7	2008	In T84 cells, steviol attenuated TNF-alpha-stimulated IkappaB --> NF-kappaB signaling.	steviol	14-21	tumor necrosis factor	Homo sapiens	33-42
18433103-9	2008	Two biological effects of steviol in the colon are demonstrated for the first time: stimulation of Cl(-) secretion and attenuation of TNF-alpha-stimulated IL-8 production.	steviol	26-33	tumor necrosis factor	Homo sapiens	134-143
18433103-9	2008	Two biological effects of steviol in the colon are demonstrated for the first time: stimulation of Cl(-) secretion and attenuation of TNF-alpha-stimulated IL-8 production.	steviol	26-33	C-X-C motif chemokine ligand 8	Homo sapiens	155-159
15644426-0	2005	Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).	steviol	63-70	solute carrier family 22 member 6	Homo sapiens	107-112
15644426-0	2005	Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).	steviol	63-70	solute carrier family 22 member 6	Homo sapiens	114-121
15644426-0	2005	Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).	steviol	63-70	solute carrier family 22 member 8	Homo sapiens	127-132
15644426-0	2005	Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).	steviol	63-70	solute carrier family 22 member 8	Homo sapiens	134-141
15644426-5	2005	In contrast, steviol showed significant, dose-dependent inhibition of PAH and ES uptake in hOAT1- or hOAT3-expressing oocytes, respectively.	steviol	13-20	solute carrier family 22 member 6	Homo sapiens	91-96
15644426-5	2005	In contrast, steviol showed significant, dose-dependent inhibition of PAH and ES uptake in hOAT1- or hOAT3-expressing oocytes, respectively.	steviol	13-20	solute carrier family 22 member 8	Homo sapiens	101-106
11504809-1	2001	An inhibitory effect of steviol, metabolite of the natural sweetener stevioside, on transepithelial transport of p-aminohippurate (J(PAH)) was observed in isolated S(2) segments of rabbit renal proximal tubules using in vitro microperfusion.	steviol	24-31	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	133-136
11504809-2	2001	Addition of steviol (0.01--0.25 mM) to the bathing medium significantly depressed J(PAH) (approximately 50--90%).	steviol	12-19	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	84-87
11504809-4	2001	To further examine this effect, a steviol concentration (0.01 mM) that produced approximately 50% inhibition of J(PAH), was chosen.	steviol	34-41	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	114-117
11504809-5	2001	Addition of 0.01 mM steviol to the bathing medium significantly depressed J(PAH) by about 50 to 60%.	steviol	20-27	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	76-79
11504809-8	2001	A higher concentration of steviol, 0.05 mM (which maximally inhibited J(PAH) when on the basolateral side), was required on the luminal side than on the basolateral side before an inhibitory effect was observed.	steviol	26-33	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	72-75
11504809-9	2001	To further examine the mechanism by which steviol inhibited J(PAH), its effect on Na(+)-K(+) ATPase activity and ATP content was determined.	steviol	42-49	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	62-65
11504809-11	2001	Kinetic analyses indicated that steviol can competitively inhibit PAH transport at the basolateral membrane.	steviol	32-39	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	66-69
34944630-8	2021	The metabolic shift by steviol was mediated through the repression of the phosphorylation of mTOR and translation initiation proteins (4E-BP1, eIF4e, eIF4B, and eIF4G).	steviol	23-30	mechanistic target of rapamycin kinase	Homo sapiens	93-97
34944630-8	2021	The metabolic shift by steviol was mediated through the repression of the phosphorylation of mTOR and translation initiation proteins (4E-BP1, eIF4e, eIF4B, and eIF4G).	steviol	23-30	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	135-141
34944630-8	2021	The metabolic shift by steviol was mediated through the repression of the phosphorylation of mTOR and translation initiation proteins (4E-BP1, eIF4e, eIF4B, and eIF4G).	steviol	23-30	eukaryotic translation initiation factor 4E	Homo sapiens	143-148
34944630-8	2021	The metabolic shift by steviol was mediated through the repression of the phosphorylation of mTOR and translation initiation proteins (4E-BP1, eIF4e, eIF4B, and eIF4G).	steviol	23-30	eukaryotic translation initiation factor 4B	Homo sapiens	150-155
34944630-8	2021	The metabolic shift by steviol was mediated through the repression of the phosphorylation of mTOR and translation initiation proteins (4E-BP1, eIF4e, eIF4B, and eIF4G).	steviol	23-30	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	161-166
15948029-6	2005	Steviol had low IC50 for hOAT1 (11.4 microM) and hOAT3 (36.5 microM) similar to that of probenecid, whereas IC50 for hOAT2 (1000 microM) and hOAT4 (285 microM) was much higher.	steviol	0-7	solute carrier family 22 member 6	Homo sapiens	25-30
15948029-6	2005	Steviol had low IC50 for hOAT1 (11.4 microM) and hOAT3 (36.5 microM) similar to that of probenecid, whereas IC50 for hOAT2 (1000 microM) and hOAT4 (285 microM) was much higher.	steviol	0-7	solute carrier family 22 member 8	Homo sapiens	49-54
15948029-9	2005	In contrast, steviol interacts directly with human OATs, in particular, hOAT1 and hOAT3, with a potency approximating probenecid, suggesting that the inhibition of OAT-mediated transport by steviol could alter renal drug clearance.	steviol	13-20	solute carrier family 22 member 6	Homo sapiens	72-77
15948029-9	2005	In contrast, steviol interacts directly with human OATs, in particular, hOAT1 and hOAT3, with a potency approximating probenecid, suggesting that the inhibition of OAT-mediated transport by steviol could alter renal drug clearance.	steviol	13-20	solute carrier family 22 member 8	Homo sapiens	82-87
15948029-9	2005	In contrast, steviol interacts directly with human OATs, in particular, hOAT1 and hOAT3, with a potency approximating probenecid, suggesting that the inhibition of OAT-mediated transport by steviol could alter renal drug clearance.	steviol	190-197	solute carrier family 22 member 6	Homo sapiens	72-77
15644426-6	2005	The IC(50) of steviol for hOAT1-mediated PAH transport was 11.1 microM compared with 62.6 microM for hOAT3-mediated ES uptake.	steviol	14-21	solute carrier family 22 member 6	Homo sapiens	26-31
15644426-7	2005	The Michaelis-Menten inhibition constants (K(i)) for steviol transport mediated by hOAT1 and hOAT3 were 2.0 +/- 0.3 and 5.4 +/- 2.0 microM, respectively.	steviol	53-60	solute carrier family 22 member 6	Homo sapiens	83-88
15644426-7	2005	The Michaelis-Menten inhibition constants (K(i)) for steviol transport mediated by hOAT1 and hOAT3 were 2.0 +/- 0.3 and 5.4 +/- 2.0 microM, respectively.	steviol	53-60	solute carrier family 22 member 8	Homo sapiens	93-98
15644426-9	2005	A low concentration of 1 microM steviol increased the efflux of [(3)H]PAH (trans-stimulated) via both hOAT1 and hOAT3.	steviol	32-39	solute carrier family 22 member 6	Homo sapiens	102-107
15644426-9	2005	A low concentration of 1 microM steviol increased the efflux of [(3)H]PAH (trans-stimulated) via both hOAT1 and hOAT3.	steviol	32-39	solute carrier family 22 member 8	Homo sapiens	112-117
15644426-11	2005	In conclusion, stevioside had no interaction with either hOAT1 or hOAT3, whereas hOAT1, hOAT3, and fOat1 were all shown to be capable of steviol transport and thus, can play a role in its renal transport and excretion.	steviol	137-144	solute carrier family 22 member 6	Homo sapiens	81-86
15644426-11	2005	In conclusion, stevioside had no interaction with either hOAT1 or hOAT3, whereas hOAT1, hOAT3, and fOat1 were all shown to be capable of steviol transport and thus, can play a role in its renal transport and excretion.	steviol	137-144	solute carrier family 22 member 8	Homo sapiens	88-93
6315213-2	1983	Application of glycyrrhetinic acid or steviol to mouse skin 1 h before TPA treatment showed a remarkable decrease in TPA-induced ODC activity.	steviol	38-45	POU domain, class 3, transcription factor 3	Mus musculus	55-61
6315213-2	1983	Application of glycyrrhetinic acid or steviol to mouse skin 1 h before TPA treatment showed a remarkable decrease in TPA-induced ODC activity.	steviol	38-45	ornithine decarboxylase, structural 1	Mus musculus	129-132
6315213-3	1983	Post-treatment with glycyrrhetinic acid or steviol 1 h after application of TPA also resulted in a considerable depression in the induction of ODC activity.	steviol	43-50	ornithine decarboxylase, structural 1	Mus musculus	143-146
6315213-5	1983	These results suggest that glycyrrhetinic acid and steviol interfere with the process of induction of epidermal ODC by TPA treatment of mouse skin.	steviol	51-58	ornithine decarboxylase, structural 1	Mus musculus	112-115
29655729-3	2018	In the present study, IPEC-J2 cells and primary hepatocytes were used to investigate the effect of rebaudioside A, stevioside and steviol on cytochrome p450 (CYP) mRNA expression.	steviol	130-137	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	141-156
32811239-7	2020	Our results showed that Steviol reduces the number of lymphocytes due to falls of CD4+, CD8+, and CD4+CD8+ subpopulations.	steviol	24-31	CD4 molecule	Homo sapiens	82-85
32811239-7	2020	Our results showed that Steviol reduces the number of lymphocytes due to falls of CD4+, CD8+, and CD4+CD8+ subpopulations.	steviol	24-31	CD8a molecule	Homo sapiens	88-91
32811239-7	2020	Our results showed that Steviol reduces the number of lymphocytes due to falls of CD4+, CD8+, and CD4+CD8+ subpopulations.	steviol	24-31	CD4 molecule	Homo sapiens	98-101
32811239-7	2020	Our results showed that Steviol reduces the number of lymphocytes due to falls of CD4+, CD8+, and CD4+CD8+ subpopulations.	steviol	24-31	CD8a molecule	Homo sapiens	102-105
29655729-0	2018	In vitro effects of rebaudioside A, stevioside and steviol on porcine cytochrome p450 expression and activity.	steviol	51-58	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	70-85
29655729-3	2018	In the present study, IPEC-J2 cells and primary hepatocytes were used to investigate the effect of rebaudioside A, stevioside and steviol on cytochrome p450 (CYP) mRNA expression.	steviol	130-137	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	158-161
29552164-5	2018	The results indicated that steviol inhibits U2OS cells through inducing G1 phase cell cycle arrest, downregulating the ability of colony formation via a mitochondrial apoptotic pathway, which was indicated by an increase of the Bax/Bcl-2 ratio and activation of cyclin-dependent kinase inhibitor 1, tumor protein 53 and cyclin-dependent kinase; whereas a Survivin and Caspase 3-independent mechanism was involved.	steviol	27-34	BCL2 associated X, apoptosis regulator	Homo sapiens	228-231
28903608-3	2018	The present study investigated kinetics of steviol glucuronidation in human liver microsome and a recombinant human UDP-glucuronosyltransferases isomer, UGT2B7, along with molecular docking to analyse interaction between UGT2B7 and steviol or glucose.	steviol	43-50	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	153-159
28903608-3	2018	The present study investigated kinetics of steviol glucuronidation in human liver microsome and a recombinant human UDP-glucuronosyltransferases isomer, UGT2B7, along with molecular docking to analyse interaction between UGT2B7 and steviol or glucose.	steviol	43-50	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	221-227
29524884-0	2018	Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation.	steviol	0-7	aquaporin 2	Canis lupus familiaris	44-48
29524884-0	2018	Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation.	steviol	0-7	aquaporin 2	Canis lupus familiaris	74-78
29524884-5	2018	Steviol, a major metabolite of the sweetening compound stevioside, was reported to retard MDCK cyst growth and enlargement by inhibiting CFTR activity.	steviol	0-7	CF transmembrane conductance regulator	Canis lupus familiaris	137-141
29524884-7	2018	Since steviol was also found to produce diuresis in rodent, it is likely that steviol might have an additional effect in retarding cyst progression, such as inhibition of AQP2 expression and function.	steviol	78-85	aquaporin 2	Canis lupus familiaris	171-175
29524884-9	2018	We found that steviol could markedly inhibit cyst growth by reducing AQP2 expression in both Pkd1-/- and MDCK cells.	steviol	14-21	aquaporin 2	Canis lupus familiaris	69-73
29524884-9	2018	We found that steviol could markedly inhibit cyst growth by reducing AQP2 expression in both Pkd1-/- and MDCK cells.	steviol	14-21	polycystin 1, transient receptor potential channel interacting	Canis lupus familiaris	93-97
29524884-11	2018	Moreover, a proteasome inhibitor, MG-132, and the lysosomotropic agent, hydroxychloroquine (HCQ) were found to abolish the inhibitory effect of steviol in Pkd1-/- cells.	steviol	144-151	polycystin 1, transient receptor potential channel interacting	Canis lupus familiaris	155-159
29524884-12	2018	Increased lysosomal enzyme marker (LAMP2) expression following steviol treatment clearly confirmed the involvement of lysosomes in steviol action.	steviol	63-70	lysosomal associated membrane protein 2	Canis lupus familiaris	35-40
29524884-12	2018	Increased lysosomal enzyme marker (LAMP2) expression following steviol treatment clearly confirmed the involvement of lysosomes in steviol action.	steviol	131-138	lysosomal associated membrane protein 2	Canis lupus familiaris	35-40
29524884-13	2018	In conclusion, our finding showed for the first time that steviol slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.	steviol	58-65	aquaporin 2	Canis lupus familiaris	107-111
29524884-13	2018	In conclusion, our finding showed for the first time that steviol slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.	steviol	58-65	aquaporin 2	Canis lupus familiaris	170-174
29899860-6	2018	The most regulated miRNAs in the steviol treated gastrointestinal cancer cells were miR-203a-3p (log2 =1.32) and miR-6088 (log2 =-2.54) in HCT-116, miR-1268b (log2 =19.85) and miR-23c (log2 =-2.05) in MKN-45.	steviol	33-40	microRNA 6088	Homo sapiens	113-121
29899860-6	2018	The most regulated miRNAs in the steviol treated gastrointestinal cancer cells were miR-203a-3p (log2 =1.32) and miR-6088 (log2 =-2.54) in HCT-116, miR-1268b (log2 =19.85) and miR-23c (log2 =-2.05) in MKN-45.	steviol	33-40	microRNA 1268b	Homo sapiens	148-157
29899860-6	2018	The most regulated miRNAs in the steviol treated gastrointestinal cancer cells were miR-203a-3p (log2 =1.32) and miR-6088 (log2 =-2.54) in HCT-116, miR-1268b (log2 =19.85) and miR-23c (log2 =-2.05) in MKN-45.	steviol	33-40	microRNA 23c	Homo sapiens	176-183
29552164-5	2018	The results indicated that steviol inhibits U2OS cells through inducing G1 phase cell cycle arrest, downregulating the ability of colony formation via a mitochondrial apoptotic pathway, which was indicated by an increase of the Bax/Bcl-2 ratio and activation of cyclin-dependent kinase inhibitor 1, tumor protein 53 and cyclin-dependent kinase; whereas a Survivin and Caspase 3-independent mechanism was involved.	steviol	27-34	BCL2 apoptosis regulator	Homo sapiens	232-237
29552164-5	2018	The results indicated that steviol inhibits U2OS cells through inducing G1 phase cell cycle arrest, downregulating the ability of colony formation via a mitochondrial apoptotic pathway, which was indicated by an increase of the Bax/Bcl-2 ratio and activation of cyclin-dependent kinase inhibitor 1, tumor protein 53 and cyclin-dependent kinase; whereas a Survivin and Caspase 3-independent mechanism was involved.	steviol	27-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	262-315
29552164-5	2018	The results indicated that steviol inhibits U2OS cells through inducing G1 phase cell cycle arrest, downregulating the ability of colony formation via a mitochondrial apoptotic pathway, which was indicated by an increase of the Bax/Bcl-2 ratio and activation of cyclin-dependent kinase inhibitor 1, tumor protein 53 and cyclin-dependent kinase; whereas a Survivin and Caspase 3-independent mechanism was involved.	steviol	27-34	caspase 3	Homo sapiens	368-377
28802235-7	2017	Using western blot analysis, it was found that steviol treatment at 100muM for 24-48h substantially enhanced and stabilized PC1 C-terminal expression, while decreasing CFTR and beta-catenin protein expression in both Prkcsh-/- and Pkd1-/- cells.	steviol	47-54	polycystin 1, transient receptor potential channel interacting	Homo sapiens	124-127
28887089-0	2017	Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.	steviol	0-7	nuclear receptor subfamily 1 group I member 2	Homo sapiens	85-88
28887089-0	2017	Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.	steviol	0-7	aryl hydrocarbon receptor	Homo sapiens	112-115
28887089-6	2017	In addition, the inhibitory activities of steviol and stevioside towards the major cytochrome P450 enzymes CYP3A4, CYP2C9, CYP2D6, CYP1A2 and CYP2B6 were evaluated in vitro.	steviol	42-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-113
28887089-6	2017	In addition, the inhibitory activities of steviol and stevioside towards the major cytochrome P450 enzymes CYP3A4, CYP2C9, CYP2D6, CYP1A2 and CYP2B6 were evaluated in vitro.	steviol	42-49	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	115-121
28887089-6	2017	In addition, the inhibitory activities of steviol and stevioside towards the major cytochrome P450 enzymes CYP3A4, CYP2C9, CYP2D6, CYP1A2 and CYP2B6 were evaluated in vitro.	steviol	42-49	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	123-129
28887089-6	2017	In addition, the inhibitory activities of steviol and stevioside towards the major cytochrome P450 enzymes CYP3A4, CYP2C9, CYP2D6, CYP1A2 and CYP2B6 were evaluated in vitro.	steviol	42-49	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	131-137
28887089-6	2017	In addition, the inhibitory activities of steviol and stevioside towards the major cytochrome P450 enzymes CYP3A4, CYP2C9, CYP2D6, CYP1A2 and CYP2B6 were evaluated in vitro.	steviol	42-49	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	142-148
28887089-7	2017	We found that steviol moderately activated the PXR and AHR, resulting in the induction of their target genes including CYP3A4 and CYP1A2 in primary human hepatocytes.	steviol	14-21	nuclear receptor subfamily 1 group I member 2	Homo sapiens	47-50
28887089-7	2017	We found that steviol moderately activated the PXR and AHR, resulting in the induction of their target genes including CYP3A4 and CYP1A2 in primary human hepatocytes.	steviol	14-21	aryl hydrocarbon receptor	Homo sapiens	55-58
28887089-7	2017	We found that steviol moderately activated the PXR and AHR, resulting in the induction of their target genes including CYP3A4 and CYP1A2 in primary human hepatocytes.	steviol	14-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	119-125
28887089-7	2017	We found that steviol moderately activated the PXR and AHR, resulting in the induction of their target genes including CYP3A4 and CYP1A2 in primary human hepatocytes.	steviol	14-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	130-136
28887089-8	2017	A weak inhibition of CYP3A4 and CYP2C9 with steviol was also found.	steviol	44-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27
28887089-8	2017	A weak inhibition of CYP3A4 and CYP2C9 with steviol was also found.	steviol	44-51	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	32-38
28754349-2	2018	However, recent data demonstrate that steviol and stevioside might act as glucocorticoid receptor (GR) agonists and thus correlate with adverse effects on metabolism.	steviol	38-45	nuclear receptor subfamily 3 group C member 1	Homo sapiens	74-97
28754349-2	2018	However, recent data demonstrate that steviol and stevioside might act as glucocorticoid receptor (GR) agonists and thus correlate with adverse effects on metabolism.	steviol	38-45	nuclear receptor subfamily 3 group C member 1	Homo sapiens	99-101
28754349-3	2018	Herein, we evaluated the impact of steviol, steviol glycosides, and a Greek-derived stevia extract on a number of key steps of GR signaling cascade in peripheral blood mononuclear cells (PBMCs) and in Jurkat leukemia cells.	steviol	35-42	nuclear receptor subfamily 3 group C member 1	Homo sapiens	127-129
28802235-4	2017	Concurrently, our previous study found steviol retarded renal cyst enlargement in an in vitro and in an in vivo models by reducing CFTR expression and activity.	steviol	39-46	CF transmembrane conductance regulator	Homo sapiens	131-135
28802235-7	2017	Using western blot analysis, it was found that steviol treatment at 100muM for 24-48h substantially enhanced and stabilized PC1 C-terminal expression, while decreasing CFTR and beta-catenin protein expression in both Prkcsh-/- and Pkd1-/- cells.	steviol	47-54	CF transmembrane conductance regulator	Homo sapiens	168-172
28802235-7	2017	Using western blot analysis, it was found that steviol treatment at 100muM for 24-48h substantially enhanced and stabilized PC1 C-terminal expression, while decreasing CFTR and beta-catenin protein expression in both Prkcsh-/- and Pkd1-/- cells.	steviol	47-54	catenin beta 1	Homo sapiens	177-189
28802235-7	2017	Using western blot analysis, it was found that steviol treatment at 100muM for 24-48h substantially enhanced and stabilized PC1 C-terminal expression, while decreasing CFTR and beta-catenin protein expression in both Prkcsh-/- and Pkd1-/- cells.	steviol	47-54	protein kinase C substrate 80K-H	Homo sapiens	217-223
28802235-7	2017	Using western blot analysis, it was found that steviol treatment at 100muM for 24-48h substantially enhanced and stabilized PC1 C-terminal expression, while decreasing CFTR and beta-catenin protein expression in both Prkcsh-/- and Pkd1-/- cells.	steviol	47-54	polycystin 1, transient receptor potential channel interacting	Homo sapiens	231-235
28802235-8	2017	In addition, steviol promoted LAMP2 expression, a lysosomal enzyme marker.	steviol	13-20	lysosomal associated membrane protein 2	Homo sapiens	30-35
28802235-9	2017	Interestingly, hydroxychloroquine (a lysosome inhibitor) treatment abolished steviol"s effect in reducing CFTR and beta-catenin protein expression.	steviol	77-84	CF transmembrane conductance regulator	Homo sapiens	106-110
28802235-9	2017	Interestingly, hydroxychloroquine (a lysosome inhibitor) treatment abolished steviol"s effect in reducing CFTR and beta-catenin protein expression.	steviol	77-84	catenin beta 1	Homo sapiens	115-127