PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17569809-4	2007	METHODS: Among 55 subjects, cardiac contractile response to the beta2-adrenergic receptor agonist terbutaline was assessed from the peak myocardial velocity of systolic shortening (Sm) in 18 subjects with the Ile-164 variant and 37 matched controls.	Isoleucine	209-212	adrenoceptor beta 2	Homo sapiens	64-89
17569809-7	2007	In patients with heart failure, subjects with Ile-164 showed further severe reduction of beta2-adrenergic-mediated increase in Sm as compared with controls with heart failure (Delta20% (5%) vs Delta39% (4%), p<0.05).	Isoleucine	46-49	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-94
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Isoleucine	182-185	insulin like 3	Homo sapiens	63-68
17630977-3	2007	To investigate how Ile(104) might regulate cAR1 activation, we assessed the consequences of substituting it with all other amino acids.	Isoleucine	19-22	nuclear receptor subfamily 1 group I member 3	Homo sapiens	43-47
17630977-7	2007	These findings are consistent with a model in which polar Ile(104) substitutions perturb the equilibrium between inactive and active cAR1 conformations in favour of the latter.	Isoleucine	58-61	nuclear receptor subfamily 1 group I member 3	Homo sapiens	133-137
17630977-8	2007	Based on homology with rhodopsin, Ile(104) is likely buried within inactive cAR1 and exposed to the cytoplasm upon activation.	Isoleucine	34-37	rhodopsin	Homo sapiens	23-32
17630977-8	2007	Based on homology with rhodopsin, Ile(104) is likely buried within inactive cAR1 and exposed to the cytoplasm upon activation.	Isoleucine	34-37	nuclear receptor subfamily 1 group I member 3	Homo sapiens	76-80
17559588-2	2007	This novel allele differs from the DQB1*0301 allele at nucleotide position 554 (C-->T), which results in a Thr to Ile amino acid exchange.	Isoleucine	117-120	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	35-39
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Isoleucine	182-185	relaxin family peptide receptor 2	Homo sapiens	69-73
17430898-6	2007	Our results also suggest that the residue Ile-323 plays a dual role in interacting with the NH(2) terminus of beta2-subunits and modulating the gating of BK channels.	Isoleucine	42-45	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	110-115
17448114-3	2007	Application of the modified analogue [Sar(1), Ile(4), Ile(8)]-AngII ([SII] AngII) allowed us to dissect the two pathways of ERK1/2 activation in native cardiac myocytes.	Isoleucine	46-49	mitogen-activated protein kinase 3	Homo sapiens	124-130
17299083-7	2007	This inhibition by isoleucine was also associated with a decline in mRNA levels for phosphoenolpyruvate carboxykinase and glucose-6-phosphatase (G6Pase) and a decreased activity of G6Pase in isolated hepatocytes.	Isoleucine	19-29	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	122-143
17299083-7	2007	This inhibition by isoleucine was also associated with a decline in mRNA levels for phosphoenolpyruvate carboxykinase and glucose-6-phosphatase (G6Pase) and a decreased activity of G6Pase in isolated hepatocytes.	Isoleucine	19-29	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	145-151
17299083-7	2007	This inhibition by isoleucine was also associated with a decline in mRNA levels for phosphoenolpyruvate carboxykinase and glucose-6-phosphatase (G6Pase) and a decreased activity of G6Pase in isolated hepatocytes.	Isoleucine	19-29	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	181-187
17498274-1	2007	HLA-A*2632 shows three nucleotides difference with HLA-A*260101 and HLA-A*2624 in exon 3 at codon 95 (ATC--> ATG) and codon 97 (AGG --> GTG), resulting in two amino acids change from Ile to Met (I95M) and Arg to Val (R97V).	Isoleucine	189-192	major histocompatibility complex, class I, A	Homo sapiens	0-5
17355965-5	2007	Interestingly, the five residues identified as "hot spots" for vitronectin binding form a contiguous epitope consisting of two exposed loops connecting the central fourstranded beta-sheet in uPAR domain I (Trp(32), Arg(58), and Ile(63)) as well as a proximal region of the flexible linker peptide connecting uPAR domains I and II (Arg(91) and Tyr(92)).	Isoleucine	228-231	vitronectin	Homo sapiens	63-74
17355965-5	2007	Interestingly, the five residues identified as "hot spots" for vitronectin binding form a contiguous epitope consisting of two exposed loops connecting the central fourstranded beta-sheet in uPAR domain I (Trp(32), Arg(58), and Ile(63)) as well as a proximal region of the flexible linker peptide connecting uPAR domains I and II (Arg(91) and Tyr(92)).	Isoleucine	228-231	plasminogen activator, urokinase receptor	Homo sapiens	191-195
17344335-3	2007	We pinpointed a single nucleotide polymorphism on CBR1 (CBR1 V88I) that encodes for a valine-to-isoleucine substitution for further characterization.	Isoleucine	96-106	carbonyl reductase 1	Homo sapiens	50-54
17344335-3	2007	We pinpointed a single nucleotide polymorphism on CBR1 (CBR1 V88I) that encodes for a valine-to-isoleucine substitution for further characterization.	Isoleucine	96-106	carbonyl reductase 1	Homo sapiens	56-60
17315172-9	2007	Mutational analysis of exon 3 of the beta-catenin gene revealed that 4 of 26 cases (15.4%) contained point mutations (3 in codon 32, GAC [Asp] to GGC [Gly]; 1 in codon 42, ACA [Thr] to ATA [Ile]), and all these 4 cases showed beta-catenin accumulation immunohistochemically.	Isoleucine	190-193	catenin beta 1	Homo sapiens	37-49
17447722-6	2007	With regard to hydrolysis, proteinase A has a preference for hydrophobic residues with Phe, Leu or Glu at the P1 position and Phe, Ile, Leu or Ala at P1", and is inhibited by IA(3), a natural and highly specific inhibitor produced by S. cerevisiae.	Isoleucine	131-134	proteinase A	Saccharomyces cerevisiae S288C	27-39
17488829-4	2007	These three residues provide a hydrophobic platform to attract the side chains of Phe-49, Ile-53, and Ile-55 in the switch I region as well as Phe-57 and Trp-74 in the interswitch region of Sec4p.	Isoleucine	90-93	Rab family GTPase SEC4	Saccharomyces cerevisiae S288C	190-195
17488829-4	2007	These three residues provide a hydrophobic platform to attract the side chains of Phe-49, Ile-53, and Ile-55 in the switch I region as well as Phe-57 and Trp-74 in the interswitch region of Sec4p.	Isoleucine	102-105	Rab family GTPase SEC4	Saccharomyces cerevisiae S288C	190-195
17395714-5	2007	Among these interactions, the MK2 Ile-366-Ala-390, which includes the bipartite nuclear localization signal, binds to the p38alpha-docking region.	Isoleucine	34-37	MAPK activated protein kinase 2	Homo sapiens	30-33
17409501-8	2007	These results suggest that L-alanine, glycine, L-isoleucine and L-leucine, but not the D-form amino acids, have a hypopigmenting effect in B16F0 melanoma cells, and that these effects are not due to the inhibition of tyrosinase activity.	Isoleucine	47-59	tyrosinase	Mus musculus	217-227
17395714-5	2007	Among these interactions, the MK2 Ile-366-Ala-390, which includes the bipartite nuclear localization signal, binds to the p38alpha-docking region.	Isoleucine	34-37	mitogen-activated protein kinase 14	Homo sapiens	122-130
16953805-8	2007	By introducing selected mutations at the positions 91, 34 and 89, we confirmed the primary importance of Ile-91 in all bacterial binding to CEACAM1 despite the inter- and intraspecies structural differences between the bacterial CEACAM-binding ligands.	Isoleucine	105-108	CEA cell adhesion molecule 1	Homo sapiens	140-147
17394124-10	2007	These results suggest that Leu, Phe and Ile residues at the sixth position of elastin-derived nonapeptides are crucial for inducing macrophage migration and in particular, Ile residue is important for the recognition by receptor insensitive to lactose.	Isoleucine	40-43	elastin	Homo sapiens	78-85
17394124-10	2007	These results suggest that Leu, Phe and Ile residues at the sixth position of elastin-derived nonapeptides are crucial for inducing macrophage migration and in particular, Ile residue is important for the recognition by receptor insensitive to lactose.	Isoleucine	172-175	elastin	Homo sapiens	78-85
17236799-1	2007	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism that affects isoleucine catabolism and ketone body metabolism.	Isoleucine	101-111	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38
17850717-4	2007	Rates of the three genotypes (Phe/Phe, Phe/Ile, Ile/Ile) of the STK15 Phe31Ile (91T-->A) SNPs in ESCC patients were 11.5%, 34.8% and 53.7%, respectively, and were not significantly different from that in the healthy group (11.9%, 36.8% and 51.3%) (chi2 = 0.35, P = 0.84).	Isoleucine	43-46	aurora kinase A	Homo sapiens	64-69
17256833-7	2007	The slightly different binding pose of 18 into the MAO-B active site seems to be forced by a bulkier Tyr residue, which replaces a smaller Ile residue present in MAO-A.	Isoleucine	139-142	monoamine oxidase B	Homo sapiens	51-56
17256833-7	2007	The slightly different binding pose of 18 into the MAO-B active site seems to be forced by a bulkier Tyr residue, which replaces a smaller Ile residue present in MAO-A.	Isoleucine	139-142	monoamine oxidase A	Homo sapiens	162-167
17493154-3	2007	At the protein level, these substitutions result in a change of a single amino acid residue in each of HLA-B*3569 and -B*4450 at positions 74 (Arg > Pro) and 80 (Thr > Ile), respectively.	Isoleucine	174-177	major histocompatibility complex, class I, B	Homo sapiens	103-108
17305371-4	2007	Remarkably, we repeatedly isolated mutants with changes in only one of the amino acids of Grx3, methionine 43, converting it to either valine, leucine, or isoleucine.	Isoleucine	155-165	glutaredoxin 3	Homo sapiens	90-94
17311419-8	2007	In addition, the 2D spectra suggest the presence of additional helix content at Ile and Val sites in the C-terminal half of Rev.	Isoleucine	80-83	Rev	Human immunodeficiency virus 1	124-127
17382017-4	2007	One of the more common mutations results from the substitution of isoleucine for threonine at Abl amino acid position 351, known as the T315I mutation.	Isoleucine	66-76	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	94-97
17183522-9	2007	However, the N-terminally blocked peptide of endothelin-1 (Ac-Asp-Ile-Ile-Trp) reacted in a very similar fashion to melatonin; this shows that tryptophan residue nitrosation could occur when it was exposed to peroxynitrite.	Isoleucine	66-69	endothelin 1	Homo sapiens	45-57
17302805-9	2007	When threonine 363 (located in the first nucleotide-binding domain, close to the Walker B motif) in Pdr5(L183P) was replaced with isoleucine, this double mutant conferred partial drug resistance.	Isoleucine	130-140	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	100-104
17010643-0	2007	How to discriminate between leucine and isoleucine by low energy ESI-TRAP MSn.	Isoleucine	40-50	moesin	Homo sapiens	74-77
17198374-2	2007	Although novel modes of ubiquitin interaction have recently been characterized, conventional ubiquitin-binding domains (UBDs) recognize ubiquitin through a hydrophobic pocket centered around isoleucine 44 and lined by residues in beta sheets 3 and 4.	Isoleucine	191-201	ubiquitin	Saccharomyces cerevisiae S288C	93-102
17198374-2	2007	Although novel modes of ubiquitin interaction have recently been characterized, conventional ubiquitin-binding domains (UBDs) recognize ubiquitin through a hydrophobic pocket centered around isoleucine 44 and lined by residues in beta sheets 3 and 4.	Isoleucine	191-201	ubiquitin	Saccharomyces cerevisiae S288C	93-102
17084860-4	2007	A comparison of all the human beta4Gal-T1 ortholog enzymes shows that this Tyr285 residue in human beta4Gal-T1 is conserved either as Tyr or Phe in all vertebrate enzymes, while in all invertebrate enzymes it is conserved as an Ile or Leu.	Isoleucine	228-231	beta-1,4-galactosyltransferase 1	Homo sapiens	30-41
17084860-4	2007	A comparison of all the human beta4Gal-T1 ortholog enzymes shows that this Tyr285 residue in human beta4Gal-T1 is conserved either as Tyr or Phe in all vertebrate enzymes, while in all invertebrate enzymes it is conserved as an Ile or Leu.	Isoleucine	228-231	beta-1,4-galactosyltransferase 1	Homo sapiens	99-110
17084860-5	2007	We find that mutation of the corresponding Ile residue to Tyr in Drosophila beta4GalNAc-T1 converts the enzyme to a beta4Gal-T1 by reducing its N-acetylgalactosaminyltransferase activity by nearly 1000-fold, while enhancing its galactosyltransferase activity by 80-fold.	Isoleucine	43-46	beta1,4-N-acetylgalactosaminyltransferase A	Drosophila melanogaster	76-90
17084860-5	2007	We find that mutation of the corresponding Ile residue to Tyr in Drosophila beta4GalNAc-T1 converts the enzyme to a beta4Gal-T1 by reducing its N-acetylgalactosaminyltransferase activity by nearly 1000-fold, while enhancing its galactosyltransferase activity by 80-fold.	Isoleucine	43-46	beta-1,4-galactosyltransferase 1	Homo sapiens	116-127
17084860-5	2007	We find that mutation of the corresponding Ile residue to Tyr in Drosophila beta4GalNAc-T1 converts the enzyme to a beta4Gal-T1 by reducing its N-acetylgalactosaminyltransferase activity by nearly 1000-fold, while enhancing its galactosyltransferase activity by 80-fold.	Isoleucine	43-46	Polypeptide N-Acetylgalactosaminyltransferase 1	Drosophila melanogaster	144-177
17084860-7	2007	Thus, it would seem that, during the evolution of vertebrates from invertebrates over 500 million years ago, beta4Gal-T1 appeared as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1.	Isoleucine	205-208	beta-1,4-galactosyltransferase 1	Homo sapiens	109-120
17174311-5	2007	Using in vitro kinase assays on peptide spots arrays, we determined the consensus phosphorylation motif for Sak to be yen-[Ile/Leu/Val]-Ser/Thr-phi-phi-X- yen/Pro (where phi denotes a large hydrophobic residue, yen is a charged residue dependent on the context of the surrounding sequence, and residues in brackets are unfavoured).	Isoleucine	123-126	polo like kinase 4	Homo sapiens	108-111
17198989-2	2007	We have identified a novel threonine-to-isoleucine missense mutation at position 353 (T353I) adjacent to the pore-lining region of domain I of the cardiac sodium channel (SCN5A) in a family with Brugada syndrome.	Isoleucine	40-50	sodium voltage-gated channel alpha subunit 5	Homo sapiens	171-176
17145868-8	2006	We have identified the MMP7 cleavage site at position Ala(515)-Ile(516) in the beta3 chain.	Isoleucine	63-66	matrix metallopeptidase 7	Homo sapiens	23-27
17579260-3	2007	The activity of TAFI is strongly influenced by genetic polymorphism, especially at amino acids Thr/Ala-147 and Thr/Ile-325.	Isoleucine	115-118	carboxypeptidase B2	Homo sapiens	16-20
17579260-6	2007	In this study, we determined normal Japanese TAFI levels for each age, sex, and genetic polymorphism of Thr/Ala-147 and Thr/Ile-325, and also showed that the TAFI level in young adult women is lower than in aged women.	Isoleucine	124-127	carboxypeptidase B2	Homo sapiens	158-162
18067039-9	2007	The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients.	Isoleucine	40-43	glutathione S-transferase pi 1	Homo sapiens	30-35
18067039-9	2007	The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients.	Isoleucine	49-52	glutathione S-transferase pi 1	Homo sapiens	30-35
18067039-9	2007	The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients.	Isoleucine	49-52	glutathione S-transferase pi 1	Homo sapiens	30-35
17046814-6	2006	The in vivo DSPP cleavage sites were on the N-terminal sides of Thr(200), Ser(330), Val(353), Leu(360), Ile(362), Ser(377), Ser(408), and Asp(458).	Isoleucine	104-107	dentin sialophosphoprotein	Homo sapiens	12-16
18030569-1	2007	PURPOSE: To evaluate the anti-tumor effects of a novel adenovirus expressing mutant p27(kip1) (Adp27-mt), which consists of a mutation of Thr-187/Pro-188 to Met-187/Ile-188.	Isoleucine	165-168	zinc ribbon domain containing 2	Homo sapiens	84-87
18030569-1	2007	PURPOSE: To evaluate the anti-tumor effects of a novel adenovirus expressing mutant p27(kip1) (Adp27-mt), which consists of a mutation of Thr-187/Pro-188 to Met-187/Ile-188.	Isoleucine	165-168	cyclin dependent kinase inhibitor 1B	Homo sapiens	88-92
17164333-6	2006	Through global phosphoproteome analysis, we identified a unique phosphosubstrate signature associated with each drug-resistant allele, including a shift in phosphorylation of two tyrosines (Tyr253 and Tyr257) in the ATP binding loop (P-loop) of BCR-ABL when Thr315 is Ile or Ala.	Isoleucine	268-271	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	245-252
17020884-6	2006	The hydrophobic face of the RK25 helix (Val-9, Val-10, Ala-11, Ala-14, and Phe-15) interacts with an exposed hydrophobic groove on the surface of recoverin lined by side-chain atoms of Trp-31, Phe-35, Phe-49, Ile-52, Tyr-53, Phe-56, Phe-57, Tyr-86, and Leu-90.	Isoleucine	209-212	recoverin	Homo sapiens	146-155
17069814-2	2006	A novel missense mutation (C11994T) in the ND4 gene, which replaces threonine with isoleucine, was observed in all of the oligoasthenozoospermic men but not in any of the normozoospermic fertile men.	Isoleucine	83-93	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	43-46
16884682-2	2006	To investigate one aspect of the interaction between IDH1 and IDH2, residues in a hydrophobic region at the heterodimer interface (Val-216, Ser-220, and Val-224 in IDH1; Ile-221, Val-225, and Val-229 in IDH2) were replaced by alanine residues in each and in both subunits.	Isoleucine	170-173	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	53-57
17172352-8	2006	Seed-specific expression of feedback-insensitive Thr deaminase in both tha1 and tha2 Thr aldolase mutants greatly increases seed Ile content, suggesting that these two Thr catabolic enzymes compete for a common substrate pool.	Isoleucine	129-132	threonine aldolase 1	Arabidopsis thaliana	71-75
17172352-8	2006	Seed-specific expression of feedback-insensitive Thr deaminase in both tha1 and tha2 Thr aldolase mutants greatly increases seed Ile content, suggesting that these two Thr catabolic enzymes compete for a common substrate pool.	Isoleucine	129-132	threonine aldolase 2	Arabidopsis thaliana	80-84
17129366-12	2006	CONCLUSION: Here we report a novel mutation of the PRNP gene found in an elderly female patient resulting in heterozygosity for isoleucine and threonine at codon 193, in which normally homozygosity for threonine is expected (T193).	Isoleucine	128-138	prion protein	Homo sapiens	51-55
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Isoleucine	234-244	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	56-61
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Isoleucine	234-244	Cbl proto-oncogene	Homo sapiens	111-114
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Isoleucine	234-244	Cbl proto-oncogene	Homo sapiens	186-189
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Isoleucine	234-244	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	193-198
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Isoleucine	234-244	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	193-198
16884682-2	2006	To investigate one aspect of the interaction between IDH1 and IDH2, residues in a hydrophobic region at the heterodimer interface (Val-216, Ser-220, and Val-224 in IDH1; Ile-221, Val-225, and Val-229 in IDH2) were replaced by alanine residues in each and in both subunits.	Isoleucine	170-173	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	62-66
16876195-6	2006	The highest thermodynamic stability was reached through the mutation strategy, where the hydrophobicity and the packing density of the solvated hydrophobic cavity in the CH1/CL interface was increased by the replacement of the hydrophilic Thr178 in the CL domain by a more hydrophobic residue, valine or isoleucine.	Isoleucine	304-314	SUN domain containing ossification factor	Homo sapiens	170-173
16828850-2	2006	Two founder alleles (1100delC and IVS2 + 1G >A) result in a truncated CHEK2 protein and the other is a missense substitution, leading to the replacement of a threonine with an isoleucine (I157T).	Isoleucine	179-189	checkpoint kinase 2	Homo sapiens	73-78
16963403-7	2006	We identified a heterozygous mutation of ATT to ACT of SOD1 gene at codon 149 in exon 5 resulting in substitution of isoleucine to threonine.	Isoleucine	117-127	superoxide dismutase 1	Homo sapiens	55-59
16911515-8	2006	The hypersensitivity of the pdr12Delta and war1Delta strains for some of these compounds indicates that Pdr12p is involved in export of the fusel acids, but not the fusel alcohols derived from leucine, isoleucine, valine, phenylalanine and tryptophan.	Isoleucine	202-212	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	104-110
16857961-2	2006	The purpose of this study was to elucidate the role of the PDZ domain-binding motif formed by the last three residues (Ser-Ile-Val) of the Na(v)1.5 C-terminus.	Isoleucine	123-126	sodium channel, voltage-gated, type V, alpha	Mus musculus	139-147
16888169-1	2006	High-affinity-binding sites for the vasoactive intestinal peptide (VIP) analogs peptide histidine/isoleucine-amide (PHI)/carboxyterminal methionine instead of isoleucine (PHM) are expressed in numerous tissues in the body but the nature of their receptors remains to be elucidated.	Isoleucine	98-108	vasoactive intestinal peptide	Rattus norvegicus	67-70
16882944-11	2006	Shepherdin[79-83] made contact with unique residues in the ATP pocket of Hsp90 (Ile-96, Asp-102, and Phe-138), did not increase Hsp70 levels in AML cells, disrupted mitochondrial function within 2 minutes of treatment, and eliminated the expression of Hsp90 client proteins.	Isoleucine	80-83	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
16597622-7	2006	The antibody epitope is dominated by a 10-residue-long protruding beta6-beta7 loop with two putative ACE2-binding hotspot residues (Ile-489 and Tyr-491).	Isoleucine	132-135	angiotensin converting enzyme 2	Homo sapiens	101-105
16636053-7	2006	Mutations of conserved hydrophobic residues (Ile-120, Ala-123, and Leu-124) located between the two Cys residues in the HCCH motif disrupt binding of the zinc-coordinating region to Cul5 and inhibit APOBEC3G degradation.	Isoleucine	45-48	cullin 5	Homo sapiens	182-186
16636053-7	2006	Mutations of conserved hydrophobic residues (Ile-120, Ala-123, and Leu-124) located between the two Cys residues in the HCCH motif disrupt binding of the zinc-coordinating region to Cul5 and inhibit APOBEC3G degradation.	Isoleucine	45-48	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	199-207
16425277-6	2006	Sequence analysis reveals that DQB1*060101 allele encodes Leu at position 9 and Asp at position 37, unique to the susceptibility to cervical cancer, whereas the other DQB1 alleles encode Phe or Tyr and Ile or Tyr at the same two positions, respectively.	Isoleucine	202-205	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	31-35
16627811-3	2006	METHODS AND RESULTS: DNA sequencing of C5L2 coding region in 61 unrelated probands identified a heterozygous variant (G968-->T) in 1 subject, resulting in Ser323-->Ile substitution in the carboxyl terminal region.	Isoleucine	170-173	complement C5a receptor 2	Homo sapiens	39-43
16897183-4	2006	Site-directed mutagenesis showed that Ile(275), Lys(276) and Arg(277) in the C-terminus of PSTD in ST8Sia IV, which is contiguous with the N-terminus of sialylmotif-S, were essential for polysialylation.	Isoleucine	38-41	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	99-108
16598065-2	2006	Nav1.8 C-terminus carries a conserved calmodulin-binding isoleucine-glutamine (IQ) motif.	Isoleucine	57-67	sodium channel, voltage-gated, type X, alpha	Mus musculus	0-6
16598065-2	2006	Nav1.8 C-terminus carries a conserved calmodulin-binding isoleucine-glutamine (IQ) motif.	Isoleucine	57-67	calmodulin 2	Mus musculus	38-48
17081365-8	2006	One missense mutation was a G-->A transition in the first nucleotide of codon 95 in SCN5A gene exon 3, which was predicted to result in substitution of Valine with Isoleucine (V95I).	Isoleucine	167-177	sodium voltage-gated channel alpha subunit 5	Homo sapiens	87-92
16702303-10	2006	Some ACE-inhibitory peptides obtained from this hydrolysate (Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe) also showed antihypertensive activity in these rats.	Isoleucine	89-92	angiotensin I converting enzyme	Rattus norvegicus	5-8
16740728-4	2006	We have created three IL-13Ralpha2 analogue peptides by substitutions of the COOH-terminal isoleucine (I) for valine (V) and the NH(2)-terminal tryptophan (W) for either alanine (A), glutamic acid (E), or nonsubstituted (W; designated as 1A9V, 1E9V, and 9V, respectively).	Isoleucine	91-101	interleukin 13 receptor subunit alpha 2	Homo sapiens	22-34
16765827-2	2006	Direct sequencing of the causative gene, the immunoglobulin mu-binding protein 2 (IGHMBP2) gene, revealed the presence of a novel frameshift mutation caused by deletion of G in exon 13 and a single base pair substitution of G to A in exon 12 resulting in substitution of isoleucine for valine.	Isoleucine	271-281	immunoglobulin mu DNA binding protein 2	Homo sapiens	45-80
16765827-2	2006	Direct sequencing of the causative gene, the immunoglobulin mu-binding protein 2 (IGHMBP2) gene, revealed the presence of a novel frameshift mutation caused by deletion of G in exon 13 and a single base pair substitution of G to A in exon 12 resulting in substitution of isoleucine for valine.	Isoleucine	271-281	immunoglobulin mu DNA binding protein 2	Homo sapiens	82-89
16756473-5	2006	Sequence analyses revealed point mutations in two different genes: the normal ACC sequence at codon 620 of the TSHR gene was replaced by ATC, changing the threonine by isoleucine (T620I); and the wild-type GGT at codon 12 of Ki-RAS mutated to TGT, replacing glycine by cysteine (G12C).	Isoleucine	168-178	thyroid stimulating hormone receptor	Homo sapiens	111-115
16427346-9	2006	A 163G>A polymorphism was identified in LDB3, which changed a valine to isoleucine (V55I) in one patient with isolated LVNC.	Isoleucine	75-85	LIM domain binding 3	Homo sapiens	43-47
16597835-9	2006	Our results further imply that Ile in place of Asn in the FDH hydrolase catalytic center is an important determinant for hydrolase catalysis as opposed to transferase catalysis.	Isoleucine	31-34	aldehyde dehydrogenase 1 family member L1	Homo sapiens	58-61
16511563-6	2006	Structure-guided mutagenesis followed by in vitro binding and in vivo colocalization assays demonstrate that a hydrophobic interaction formed by Phe 330 of gephyrin and Phe 398 and Ile 400 of the GlyR beta-loop is crucial for binding.	Isoleucine	181-184	gephyrin	Homo sapiens	156-164
16263169-5	2006	Real-time PCR analysis of hBD-1 in human colon cells, HCT-116, revealed upregulation after treatment with arginine, isoleucine, and bovine serum albumin (BSA).	Isoleucine	116-126	defensin beta 1	Homo sapiens	26-31
16536738-4	2006	We also showed that Rab6A" is required for cell cycle progression through mitosis and identify Ile(62) as a key residue for uncoupling Rab6A" functions in mitosis and retrograde trafficking.	Isoleucine	95-98	RAB6A, member RAS oncogene family	Homo sapiens	20-25
16536738-4	2006	We also showed that Rab6A" is required for cell cycle progression through mitosis and identify Ile(62) as a key residue for uncoupling Rab6A" functions in mitosis and retrograde trafficking.	Isoleucine	95-98	RAB6A, member RAS oncogene family	Homo sapiens	135-140
16431912-3	2006	In the present study, we characterized the contribution of three residues in the beta5"-loop, Val-407, Ile-408, and Leu-412, to the function of hPTL.	Isoleucine	103-106	pancreatic lipase	Homo sapiens	144-148
16604067-2	2006	The abnormal behavior of unc-17(e245) mutants, which have a glycine-to-arginine substitution in a transmembrane domain, is markedly improved by a mutant synaptobrevin with an isoleucine-to-aspartate substitution in its transmembrane domain.	Isoleucine	175-185	Vesicular acetylcholine transporter unc-17	Caenorhabditis elegans	25-31
16636649-6	2006	A heterozygous missense mutation, consisting of a G to A transition at nucleotide position 384 in TGFBI exon 4 that predicts a valine (GTT) to isoleucine (ATT) replacement in residue 113 (Val113Ile) of the TGFBI protein was identified.	Isoleucine	143-153	transforming growth factor beta induced	Homo sapiens	98-103
16636649-6	2006	A heterozygous missense mutation, consisting of a G to A transition at nucleotide position 384 in TGFBI exon 4 that predicts a valine (GTT) to isoleucine (ATT) replacement in residue 113 (Val113Ile) of the TGFBI protein was identified.	Isoleucine	143-153	transforming growth factor beta induced	Homo sapiens	206-211
16511563-6	2006	Structure-guided mutagenesis followed by in vitro binding and in vivo colocalization assays demonstrate that a hydrophobic interaction formed by Phe 330 of gephyrin and Phe 398 and Ile 400 of the GlyR beta-loop is crucial for binding.	Isoleucine	181-184	glycine receptor beta	Homo sapiens	196-205
16431216-2	2006	DNA analysis of the LPL gene revealed two mutations, one of which was a novel homozygous G-->C substitution, resulting in the conversion of a translation initiation codon methionine to isoleucine (LPL-1).	Isoleucine	188-198	lipoprotein lipase	Homo sapiens	20-23
16410248-4	2006	With the P(2)-Pro(1) library, FAP preferred Ile, Pro, or Arg at the P(2) residue; however, DPP-4 showed broad reactivity against this library, precluding selectivity.	Isoleucine	44-47	fibroblast activation protein alpha	Homo sapiens	30-33
16431216-2	2006	DNA analysis of the LPL gene revealed two mutations, one of which was a novel homozygous G-->C substitution, resulting in the conversion of a translation initiation codon methionine to isoleucine (LPL-1).	Isoleucine	188-198	lysophospholipase 1	Homo sapiens	200-205
16489746-2	2006	Correlating with a Val-to-Ile residue substitution in the bsNOS heme pocket, the Fe(II)-NO complex with both l-Arg and NOHA is more bent than the Fe(II)-NO, l-Arg complex of mammalian eNOS [Li, H., Raman, C. S., Martasek, P., Masters, B. S. S., and Poulos, T. L. (2001) Biochemistry 40, 5399-5406].	Isoleucine	26-29	nitric oxide synthase 3	Homo sapiens	184-188
16272152-2	2006	Here we described a separate site in hSERT TM3 (Ile-172) that impacts (RS)-CIT recognition when switched to the corresponding Drosophila SERT residue (I172M).	Isoleucine	48-51	solute carrier family 6 member 4	Homo sapiens	37-42
16371349-7	2006	Crucial residues include a three-residue hydrophobic "plug" from the UL54 peptide and Ile(135) of UL44, which forms a critical intramolecular hydrophobic anchor for interactions between the connector loop and the peptide.	Isoleucine	86-89	DNA polymerase processivity subunit	Human betaherpesvirus 5	98-102
16461916-6	2006	We mutated one such buried pair, Tyr-236 and Thr-253 to Phe-236 and Ile-253 (as found in the paralogs p63 and p73), and stabilized p53 by 1.6 kcal/mol.	Isoleucine	68-71	tumor protein p63	Homo sapiens	102-105
16461916-6	2006	We mutated one such buried pair, Tyr-236 and Thr-253 to Phe-236 and Ile-253 (as found in the paralogs p63 and p73), and stabilized p53 by 1.6 kcal/mol.	Isoleucine	68-71	tumor protein p73	Homo sapiens	110-113
16461916-6	2006	We mutated one such buried pair, Tyr-236 and Thr-253 to Phe-236 and Ile-253 (as found in the paralogs p63 and p73), and stabilized p53 by 1.6 kcal/mol.	Isoleucine	68-71	tumor protein p53	Homo sapiens	131-134
16272152-2	2006	Here we described a separate site in hSERT TM3 (Ile-172) that impacts (RS)-CIT recognition when switched to the corresponding Drosophila SERT residue (I172M).	Isoleucine	48-51	tropomyosin 3	Homo sapiens	43-46
16272152-2	2006	Here we described a separate site in hSERT TM3 (Ile-172) that impacts (RS)-CIT recognition when switched to the corresponding Drosophila SERT residue (I172M).	Isoleucine	48-51	Serotonin transporter	Drosophila melanogaster	38-42
16260780-5	2006	Further biochemical analysis of this variant and others revealed that Leu(127) and Ile(128) have different roles in stabilizing the active conformation of CRP in the absence of cAMP.	Isoleucine	83-86	catabolite gene activator protein	Escherichia coli	155-158
16182535-5	2006	Structure-based protein design was used to identify two amino-acid residues, isoleucine 846 and methionine 883, that control PTPH1"s sensitivity to oxalylaminoindole PTP inhibitors.	Isoleucine	77-87	protein tyrosine phosphatase non-receptor type 3	Homo sapiens	125-130
16182535-5	2006	Structure-based protein design was used to identify two amino-acid residues, isoleucine 846 and methionine 883, that control PTPH1"s sensitivity to oxalylaminoindole PTP inhibitors.	Isoleucine	77-87	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	125-128
16704745-3	2006	The immunostimulatory characteristic of hIL-10 has been attributed to a single amino acid, isoleucine at position 87, which in vIL-10 is alanine.	Isoleucine	91-101	interleukin 10	Homo sapiens	40-46
16704745-4	2006	A mutant hIL-10 in which isoleucine has been substituted (mut.hIL-10) is biologically active with only immunosuppressive, but not immunostimulatory, functions, making it a potentially superior therapeutic for inflammatory diseases.	Isoleucine	25-35	interleukin 10	Homo sapiens	9-15
16704745-4	2006	A mutant hIL-10 in which isoleucine has been substituted (mut.hIL-10) is biologically active with only immunosuppressive, but not immunostimulatory, functions, making it a potentially superior therapeutic for inflammatory diseases.	Isoleucine	25-35	interleukin 10	Homo sapiens	62-68
16328501-7	2006	Conservative mutations that reduced or inactivated uptake led us to identify Ser(729), Ile(746) and Met(762) (part of the conserved GMN motif) as critical amino acid residues in Alr1.	Isoleucine	87-90	Mg(2+) transporter ALR1	Saccharomyces cerevisiae S288C	178-182
17013727-3	2006	Further examinations established multiple endocrine neoplasia type 1 (MEN1) with a germline mutation at codon 1153 (T->A) in exon 7, causing an amino-acid change, from isoleucine to asparagine (Ile348Asn), in the MEN1 gene.	Isoleucine	168-178	menin 1	Homo sapiens	33-68
16763387-3	2006	RESULTS: SSCP analysis and direct sequencing of exon 3 of a female patient with a hypoplastic thyroid gland revealed two heterozygous mutations in Pax8 resulting in a transition of T to C (codon 34) and G to A (codon 35), replacing isoleucine by threonine and valine by isoleucine.	Isoleucine	232-242	paired box 8	Homo sapiens	147-151
16763387-3	2006	RESULTS: SSCP analysis and direct sequencing of exon 3 of a female patient with a hypoplastic thyroid gland revealed two heterozygous mutations in Pax8 resulting in a transition of T to C (codon 34) and G to A (codon 35), replacing isoleucine by threonine and valine by isoleucine.	Isoleucine	270-280	paired box 8	Homo sapiens	147-151
17013727-3	2006	Further examinations established multiple endocrine neoplasia type 1 (MEN1) with a germline mutation at codon 1153 (T->A) in exon 7, causing an amino-acid change, from isoleucine to asparagine (Ile348Asn), in the MEN1 gene.	Isoleucine	168-178	menin 1	Homo sapiens	70-74
16324895-7	2005	It is proposed that the C-terminus of PEA-15 ((121)LXLXXXXKK(129)) is a reverse DEJL domain [which has a general consensus of R/K-phi(A)-X(3/4)-phi(B), where phi(A) and phi(B) are hydrophobic residues (Leu, Ile, or Val)], which mediates one arm of a bidentate PEA-15 interaction with ERK2.	Isoleucine	207-210	proliferation and apoptosis adaptor protein 15	Homo sapiens	38-44
16737620-7	2006	CONCLUSION: These findings suggest that STK15 Phe/Ile polymorphism may be a genetic susceptibility factor for colorectal cancer among Chinese.	Isoleucine	50-53	aurora kinase A	Homo sapiens	40-45
16269407-7	2005	Ile-35, Ile-43, and Ile-44 are only involved in the stable association with Na,K-ATPase.	Isoleucine	0-3	ATPase Na+/K+ transporting subunit beta 1 L homeolog	Xenopus laevis	76-87
16269407-7	2005	Ile-35, Ile-43, and Ile-44 are only involved in the stable association with Na,K-ATPase.	Isoleucine	8-11	ATPase Na+/K+ transporting subunit beta 1 L homeolog	Xenopus laevis	76-87
16269407-7	2005	Ile-35, Ile-43, and Ile-44 are only involved in the stable association with Na,K-ATPase.	Isoleucine	8-11	ATPase Na+/K+ transporting subunit beta 1 L homeolog	Xenopus laevis	76-87
16269407-8	2005	Glu-26, Met-30, and Ile-44 are important for the functional effect and/or the efficient association of FXYD7 with Na,K-ATPase, consistent with the prediction that these amino acids contact TM domain 9 of the alpha subunit (Li, C., Grosdidier, A., Crambert, G., Horisberger, J.-D., Michielin, O., and Geering, K. (2004) J. Biol.	Isoleucine	20-23	ATPase Na+/K+ transporting subunit beta 1 L homeolog	Xenopus laevis	114-125
16314536-3	2005	Deletion of CYC8 confers sensitivity to an inhibitor of isoleucine/valine biosynthesis and impairs activation of Gcn4p-dependent reporters and authentic amino acid biosynthetic target genes.	Isoleucine	56-66	transcription regulator CYC8	Saccharomyces cerevisiae S288C	12-16
16186102-3	2005	Comparison of sequence alignments indicated that GLUTs 2, 5, and 7 all had an isoleucine residue at position "314" (GLUT7), whereas the non-fructose-transporting isoforms, GLUTs 1, 3, and 4, had a valine at this position.	Isoleucine	78-88	solute carrier family 2 member 7	Homo sapiens	116-121
16186102-6	2005	Energy minimization modeling of GLUT7 indicated that Ile-314 projects from transmembrane domain 7 (TM7) into the lumen of the aqueous pore, where it could form a hydrophobic interaction with tryptophan 89 from TM2.	Isoleucine	53-56	solute carrier family 2 member 7	Homo sapiens	32-37
16194549-7	2005	The apparent Km of BCATm in isolated AS30D cells mitochondria for leucine, isoleucine and valine was 1.0+/-0.02, 1.3+/-0.1 and 2.1+/-0.1 mM, respectively.	Isoleucine	75-85	branched chain amino acid transaminase 2	Rattus norvegicus	19-24
16186124-6	2005	Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)).	Isoleucine	213-216	phytanoyl-CoA 2-hydroxylase	Homo sapiens	10-14
16157588-10	2005	Substitution of Ile-781, the Ca(V)1.2 residue corresponding to Ile-745 in Ca(V)1.4, by residues of different hydrophobicity, size and polarity shifted channel activation in the hyperpolarizing direction (I781P > I781T > I781N > I781A > I781L).	Isoleucine	16-19	immunoglobulin lambda variable 2-8	Homo sapiens	29-37
16157588-10	2005	Substitution of Ile-781, the Ca(V)1.2 residue corresponding to Ile-745 in Ca(V)1.4, by residues of different hydrophobicity, size and polarity shifted channel activation in the hyperpolarizing direction (I781P > I781T > I781N > I781A > I781L).	Isoleucine	16-19	immunoglobulin lambda variable 2-14	Homo sapiens	74-82
16157588-10	2005	Substitution of Ile-781, the Ca(V)1.2 residue corresponding to Ile-745 in Ca(V)1.4, by residues of different hydrophobicity, size and polarity shifted channel activation in the hyperpolarizing direction (I781P > I781T > I781N > I781A > I781L).	Isoleucine	63-66	immunoglobulin lambda variable 2-8	Homo sapiens	29-37
16157588-10	2005	Substitution of Ile-781, the Ca(V)1.2 residue corresponding to Ile-745 in Ca(V)1.4, by residues of different hydrophobicity, size and polarity shifted channel activation in the hyperpolarizing direction (I781P > I781T > I781N > I781A > I781L).	Isoleucine	63-66	immunoglobulin lambda variable 2-14	Homo sapiens	74-82
16157588-14	2005	These findings indicate that Ile-781 substitutions both destabilize the closed conformation and stabilize the open conformation of Ca(V)1.2.	Isoleucine	29-32	immunoglobulin lambda variable 2-8	Homo sapiens	131-139
16159876-6	2005	Upon mdm2 binding this motif becomes a well defined full helix turn whose hydrophobic face formed by the side chains of Ile-50, Trp-53, and Phe-54 inserts deeply into the helix binding pocket.	Isoleucine	120-123	MDM2 proto-oncogene	Homo sapiens	5-9
16159876-6	2005	Upon mdm2 binding this motif becomes a well defined full helix turn whose hydrophobic face formed by the side chains of Ile-50, Trp-53, and Phe-54 inserts deeply into the helix binding pocket.	Isoleucine	120-123	tumor protein p53	Homo sapiens	128-134
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Isoleucine	3-13	glutathione S-transferase pi 1	Homo sapiens	81-86
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Isoleucine	15-18	glutathione S-transferase pi 1	Homo sapiens	81-86
16176262-8	2005	The human SCHAD gene and its protein product, SCHAD, are potential targets for intervention in conditions, such as Alzheimer"s disease, Parkinson"s disease, and an X-linked mental retardation, that may arise from the impaired degradation of branched chain fatty acid and isoleucine.	Isoleucine	271-281	hydroxyacyl-CoA dehydrogenase	Homo sapiens	10-15
16157585-5	2005	The changing of Ile-383 and Gln-385 in toxin B to serine and alanine, respectively, largely increased the acceptance of UDP-N-acetylglucosamine as a sugar donor for modification of RhoA.	Isoleucine	16-19	ras homolog family member A	Homo sapiens	181-185
15994310-2	2005	The second intracellular loop (IL2) of SERT contains consensus sequences for cGMP-dependent protein kinase and protein kinase C. A 24-residue region of SERT including IL2, from Ile-270 through Ser-293, was analyzed by cysteine-scanning mutagenesis and chemical modification.	Isoleucine	177-180	interleukin 2	Homo sapiens	31-34
15994310-2	2005	The second intracellular loop (IL2) of SERT contains consensus sequences for cGMP-dependent protein kinase and protein kinase C. A 24-residue region of SERT including IL2, from Ile-270 through Ser-293, was analyzed by cysteine-scanning mutagenesis and chemical modification.	Isoleucine	177-180	solute carrier family 6 member 4	Homo sapiens	39-43
15994310-2	2005	The second intracellular loop (IL2) of SERT contains consensus sequences for cGMP-dependent protein kinase and protein kinase C. A 24-residue region of SERT including IL2, from Ile-270 through Ser-293, was analyzed by cysteine-scanning mutagenesis and chemical modification.	Isoleucine	177-180	solute carrier family 6 member 4	Homo sapiens	152-156
15994310-2	2005	The second intracellular loop (IL2) of SERT contains consensus sequences for cGMP-dependent protein kinase and protein kinase C. A 24-residue region of SERT including IL2, from Ile-270 through Ser-293, was analyzed by cysteine-scanning mutagenesis and chemical modification.	Isoleucine	177-180	interleukin 2	Homo sapiens	167-170
16187920-6	2005	This mutation results in a new amino acid exchange of valine for isoleucine in TSHR codon 568 (Ile568Val).	Isoleucine	65-75	thyroid stimulating hormone receptor	Homo sapiens	79-83
16135198-5	2005	Among all pre-treatment isolates, the dhfr triple mutation (Ile-51 + Arg-59 + Asn-108) was detected in 47%.	Isoleucine	60-63	dihydrofolate reductase	Homo sapiens	38-42
15967801-5	2005	We have demonstrated that certain Ala mutations in the intracellular segments of transmembrane domains 3 (Met(132)), 5 (Met(227)), 6 (Phe(272) and Phe(276)), and 7 (Ile(322) and Tyr(323)) of the human GnRH receptor allosterically increased ligand binding affinity for GnRH II but had little effect on GnRH I binding affinity.	Isoleucine	165-168	gonadotropin releasing hormone receptor	Homo sapiens	201-214
15967801-5	2005	We have demonstrated that certain Ala mutations in the intracellular segments of transmembrane domains 3 (Met(132)), 5 (Met(227)), 6 (Phe(272) and Phe(276)), and 7 (Ile(322) and Tyr(323)) of the human GnRH receptor allosterically increased ligand binding affinity for GnRH II but had little effect on GnRH I binding affinity.	Isoleucine	165-168	gonadotropin releasing hormone 2	Homo sapiens	268-275
15967801-5	2005	We have demonstrated that certain Ala mutations in the intracellular segments of transmembrane domains 3 (Met(132)), 5 (Met(227)), 6 (Phe(272) and Phe(276)), and 7 (Ile(322) and Tyr(323)) of the human GnRH receptor allosterically increased ligand binding affinity for GnRH II but had little effect on GnRH I binding affinity.	Isoleucine	165-168	gonadotropin releasing hormone 1	Homo sapiens	201-205
16081073-6	2005	Replacing this residue with a neutral alanine or isoleucine, caused a dramatic decrease in CERK activity to 1% and 29%, respectively, compared to CERK, but had no effect on substrate affinity.	Isoleucine	49-59	ceramide kinase	Homo sapiens	91-95
16081073-6	2005	Replacing this residue with a neutral alanine or isoleucine, caused a dramatic decrease in CERK activity to 1% and 29%, respectively, compared to CERK, but had no effect on substrate affinity.	Isoleucine	49-59	ceramide kinase	Homo sapiens	146-150
16239724-1	2005	Porcine insulin differs in sequence from bovine insulin at residues A8 (Thr in porcine-->Ala in bovine) and A10 (Ile in porcine-->Val in bovine).	Isoleucine	116-119	insulin	Bos taurus	8-15
16239724-9	2005	As a consequence of the loss of the C(delta1) atom from the isoleucine residue in porcine insulin to produce valine in bovine insulin, there is a 0.36 A decrease in the distance between independent pairs of C(beta) atoms and a 0.24 A decrease in the c dimension of the unit cell.	Isoleucine	60-70	insulin	Bos taurus	90-97
16239724-9	2005	As a consequence of the loss of the C(delta1) atom from the isoleucine residue in porcine insulin to produce valine in bovine insulin, there is a 0.36 A decrease in the distance between independent pairs of C(beta) atoms and a 0.24 A decrease in the c dimension of the unit cell.	Isoleucine	60-70	insulin	Bos taurus	126-133
15994310-4	2005	From the pattern of sensitivity, IL2 appears to extend from Trp-271 through Ile-290, a significantly longer region than that initially predicted by hydropathy analysis.	Isoleucine	76-79	interleukin 2	Homo sapiens	33-36
15992850-9	2005	In addition, we found a correlation between side-chain beta-branching at amino acid position 166 and binding of Mab F7-299 to oligomeric Env and cell-to-cell fusion, suggesting local secondary structure constraints in the region around isoleucine-166 as one determinant of gp135 RBS exposure and antibody binding.	Isoleucine	236-246	endogenous retrovirus group K member 20	Homo sapiens	137-140
16284423-4	2005	We detected an A/C nonsynonymous heteroplasmic site corresponding to putative amino acids, Ile or Met, in NADH dehydrogenase subunit-5 (ND5) region of chum salmon.	Isoleucine	91-94	NADH dehydrogenase subunit 5	Oncorhynchus keta	106-134
16176262-8	2005	The human SCHAD gene and its protein product, SCHAD, are potential targets for intervention in conditions, such as Alzheimer"s disease, Parkinson"s disease, and an X-linked mental retardation, that may arise from the impaired degradation of branched chain fatty acid and isoleucine.	Isoleucine	271-281	hydroxyacyl-CoA dehydrogenase	Homo sapiens	46-51
15911627-6	2005	1) The putative ancillary peroxisomal targeting information (PTS1A) in human AGT is located entirely within the smaller C-terminal structural domain of 110 amino acids, with the sequence between Val-324 and Ile-345 being the most likely candidate region.	Isoleucine	207-210	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	77-80
16014854-8	2005	However, the presence of the triple mutant dhfr (Ile-51/Arg-59/Asn-108) with the dhps Gly-437 genotype in all recurring infections, suggests the importance of codon 59 and 437 alleles in susceptibility to TRM/SMX.	Isoleucine	49-52	dihydrofolate reductase	Homo sapiens	43-47
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	37-40	glutathione S-transferase pi 1	Homo sapiens	30-35
15774487-9	2005	The TAP2 codons 379 isoleucine carriers and LMP7 codons 145 lysine carriers were found to be more susceptible to esophageal carcinoma (OR = 2.74, 95% CI = 1.15-6.49, P = 0.023 for TAP2; OR = 2.19, 95% CI = 1.09-4.37, P = 0.027 for LMP7).	Isoleucine	20-30	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	4-8
16009141-4	2005	RESULTS: The activities of prolidase I and II against glycylproline and methionylproline were enhanced by glycine, L- and D-isoforms of alanine and serine and D-isoforms of valine, leucine and isoleucine.	Isoleucine	193-203	peptidase D	Homo sapiens	27-36
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	51-54	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	51-54	glutathione S-transferase pi 1	Homo sapiens	30-35
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Isoleucine	51-54	glutathione S-transferase pi 1	Homo sapiens	30-35
16235998-5	2005	Among the subjects, the genotype frequency of CYP1A1 Ile462Val was 56.8% for Ile/Ile, 38.1% for Ile/Val and 5.1% for Val/Val.	Isoleucine	53-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	46-52
16235998-5	2005	Among the subjects, the genotype frequency of CYP1A1 Ile462Val was 56.8% for Ile/Ile, 38.1% for Ile/Val and 5.1% for Val/Val.	Isoleucine	77-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	46-52
16235998-5	2005	Among the subjects, the genotype frequency of CYP1A1 Ile462Val was 56.8% for Ile/Ile, 38.1% for Ile/Val and 5.1% for Val/Val.	Isoleucine	77-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	46-52
15878859-4	2005	The Clapper mutation has been identified to be a missense mutation of the gammaB-crystallin gene that replaces the 4th isoleucine residue with a phenylalanine (gammaB-I4F).	Isoleucine	119-129	crystallin, gamma B	Mus musculus	74-91
15832374-5	2005	By site-directed mutagenesis, two mutants of cytochrome P450scc (Asp405Ile and Glu124Ile) expressed in Escherichia coli, were realized by replacing with isoleucines.	Isoleucine	153-164	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	45-63
15994821-2	2005	An analysis of the human genome demonstrated that ERV3 is one of a group of 41 highly related elements (ERV3-like HERVs) which use proline, isoleucine, or arginine tRNA in their primer binding sites.	Isoleucine	140-150	endogenous retrovirus group 3 member 1, envelope	Homo sapiens	50-54
15980970-5	2005	Two previously described beta-catenin mutations in codon 33 TCT(Ser) > TGT(Cys) and codon 37 TCT(Ser) > TTT(Phe), whereas three novel mutations in codon 41 ACC(Thr) > ATC(Ile), codon 33 TCT(Ser) > TAT(Tyr) and codon 32 GAC(Asp) > AAC(Asn) were observed.	Isoleucine	180-183	catenin beta 1	Homo sapiens	25-37
15994821-2	2005	An analysis of the human genome demonstrated that ERV3 is one of a group of 41 highly related elements (ERV3-like HERVs) which use proline, isoleucine, or arginine tRNA in their primer binding sites.	Isoleucine	140-150	endogenous retrovirus group 3 member 1, envelope	Homo sapiens	104-108
15943474-2	2005	The gamma-turn mimetics were incorporated into angiotensin II (Ang II) replacing the Val(3)-Tyr(4)-Ile(5) or Tyr(4)-Ile(5) peptide segments.	Isoleucine	99-102	angiotensinogen	Rattus norvegicus	47-61
15882971-2	2005	Sequence analysis showed that the codon 152 of C2GnT has a polymorphism having GTT encoding valine or ATT encoding isoleucine.	Isoleucine	115-125	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	47-52
15907786-5	2005	The data confirm the role of the JNK3 residues Ile-70 and Val-196 in both inhibitor and ATP-binding.	Isoleucine	47-50	mitogen-activated protein kinase 10	Homo sapiens	33-37
15943474-2	2005	The gamma-turn mimetics were incorporated into angiotensin II (Ang II) replacing the Val(3)-Tyr(4)-Ile(5) or Tyr(4)-Ile(5) peptide segments.	Isoleucine	99-102	angiotensinogen	Rattus norvegicus	63-69
15938644-8	2005	A number of substitutions in the YFF peptide outlined the importance of Ile and Arg at positions n - 1 and n + 6 in addition to the central triplet, to ensure efficient phosphorylation by ALK.	Isoleucine	72-75	ALK receptor tyrosine kinase	Homo sapiens	188-191
15897968-7	2005	The deduced protein structure of NYD-SP5 was found to contain an IQ motif (a short calmodulin-binding motif containing conserved Ile and Gln residues), a Carbamate kinase-like domain, a Zn-dependent exopeptidase domain and a lactate dehydrogenase (LDH) C-terminal-like domain.	Isoleucine	129-132	IQ motif containing H	Homo sapiens	33-40
15591158-9	2005	Oral administration of leucine or isoleucine without a glucose load induced GLUT4 and GLUT1 translocation to the plasma membrane.	Isoleucine	34-44	solute carrier family 2 member 4	Rattus norvegicus	76-81
15591158-9	2005	Oral administration of leucine or isoleucine without a glucose load induced GLUT4 and GLUT1 translocation to the plasma membrane.	Isoleucine	34-44	solute carrier family 2 member 1	Rattus norvegicus	86-91
16050984-3	2005	The new sequence variant of A9016G in the ATPase 6 gene changed highly conserved amino acid of isoleucine to valine, has not been found in the rest of 13 LHON patients and controls.	Isoleucine	95-105	mitochondrially encoded ATP synthase 6	Homo sapiens	42-50
15899855-3	2005	Deletion and mutagenesis studies identified a nuclear export signal (NES) in the intervening region of Keap1 comprised of hydrophobic leucine and isoleucine residues in agreement with a traditional NES consensus sequence.	Isoleucine	146-156	kelch like ECH associated protein 1	Homo sapiens	103-108
15900216-5	2005	The GSTP1 gene displays a polymorphism at codon 105 resulting in an Ile to Val substitution, which alters the enzymatic activity of the protein, and this has been suggested as a putative high-risk genotype in various cancers.	Isoleucine	68-71	glutathione S-transferase pi 1	Homo sapiens	4-9
15716272-6	2005	Similarly, mutation of Met414 in helix 3 to leucine or of Leu591 in helix 12 to isoleucine (the corresponding residues found in NGFI-B) significantly affects Nurr1 transactivation.	Isoleucine	80-90	nuclear receptor subfamily 4 group A member 1	Homo sapiens	128-134
15716272-6	2005	Similarly, mutation of Met414 in helix 3 to leucine or of Leu591 in helix 12 to isoleucine (the corresponding residues found in NGFI-B) significantly affects Nurr1 transactivation.	Isoleucine	80-90	nuclear receptor subfamily 4 group A member 2	Homo sapiens	158-163
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Isoleucine	207-210	complement C5a receptor 1	Homo sapiens	61-65
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Isoleucine	207-210	complement C5a receptor 1	Homo sapiens	61-64
15661745-4	2005	Conversely, mutation of C5aR transmembrane residue Ile(116) to the smaller Ala (I116A) makes the receptor respond to peptide 2 as an agonist (Gerber, B. O., Meng, E. C., Dotsch, V., Baranski, T. J., and Bourne, H. R. (2001) J. Biol.	Isoleucine	51-54	complement C5a receptor 1	Homo sapiens	24-28
15867347-2	2005	Two coding single nucleotide polymorphisms in Aurora-A, 91T>A [phenylalanine/isoleucine (F/I)] and 169G>A [valine/isoleucine (V/I)], create four haplotypes, 91T-169G, 91A-169G, 91T-169A, and 91A-169A.	Isoleucine	77-87	aurora kinase A	Homo sapiens	46-54
15860413-3	2005	17Beta-HSD10/SCHAD is essential for the metabolism of isoleucine and branched-chain fatty acids.	Isoleucine	54-64	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	13-18
15897456-7	2005	Molecular genetic analyses identified a previously undescribed nucleotide substitution in CACNA1F that is predicted to encode an isoleucine to threonine substitution at CACNA1F residue 745.	Isoleucine	129-139	calcium voltage-gated channel subunit alpha1 F	Homo sapiens	90-97
15897456-7	2005	Molecular genetic analyses identified a previously undescribed nucleotide substitution in CACNA1F that is predicted to encode an isoleucine to threonine substitution at CACNA1F residue 745.	Isoleucine	129-139	calcium voltage-gated channel subunit alpha1 F	Homo sapiens	169-176
15710600-6	2005	Ile-199 is conserved in all known MAO B sequences except bovine MAO B, which has Phe in this position (the sequence of sheep MAO B is unknown).	Isoleucine	0-3	monoamine oxidase B	Bos taurus	34-39
15710600-0	2005	Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.	Isoleucine	17-27	monoamine oxidase B	Homo sapiens	98-117
15710600-6	2005	Ile-199 is conserved in all known MAO B sequences except bovine MAO B, which has Phe in this position (the sequence of sheep MAO B is unknown).	Isoleucine	0-3	monoamine oxidase B	Bos taurus	64-69
15710600-6	2005	Ile-199 is conserved in all known MAO B sequences except bovine MAO B, which has Phe in this position (the sequence of sheep MAO B is unknown).	Isoleucine	0-3	amine oxidase [flavin-containing] B	Ovis aries	64-69
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Isoleucine	305-308	ubiquitin	Saccharomyces cerevisiae S288C	57-66
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Isoleucine	305-308	ubiquitin	Saccharomyces cerevisiae S288C	133-142
15837191-5	2005	These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.	Isoleucine	305-308	ubiquitin	Saccharomyces cerevisiae S288C	133-142
15790420-6	2005	RESULTS: Valine, isoleucine, leucine were significantly decreased in PBC and PSC.	Isoleucine	17-27	PSC	Homo sapiens	77-80
15763240-8	2005	Isoleucine alone had no significant effect on TGF-alpha secretion but this agent blocked leucine-induced TGF-alpha secretion.	Isoleucine	0-10	transforming growth factor alpha	Rattus norvegicus	105-114
15743189-1	2005	A cyclic analogue, [cyclo(87-99)MBP(87)(-)(99)], of the human immunodominant MBP(87)(-)(99) epitope, was designed based on ROESY/NMR distance information and modeling data for linear epitope 87-99, taking into account T-cell (Phe(89), Lys(91), Pro(96)) and HLA (His(88), Phe(90), Ile(93)) contact side-chain information.	Isoleucine	280-283	myelin basic protein	Homo sapiens	32-35
15743189-1	2005	A cyclic analogue, [cyclo(87-99)MBP(87)(-)(99)], of the human immunodominant MBP(87)(-)(99) epitope, was designed based on ROESY/NMR distance information and modeling data for linear epitope 87-99, taking into account T-cell (Phe(89), Lys(91), Pro(96)) and HLA (His(88), Phe(90), Ile(93)) contact side-chain information.	Isoleucine	280-283	myelin basic protein	Homo sapiens	77-80
15787961-3	2005	The hydrophobic cores of PLB and WSPLB contain Leu and Ile at the a- and d-positions of a heptad repeat (abcdefg) from residues 31-52, while residues 21-30 are rich in polar amino acids at these positions.	Isoleucine	55-58	phospholamban	Homo sapiens	25-28
15556948-6	2005	Substitution of hydrophobic Leu-74 and Ile-75 with serines in the helical domain abrogated Vpx nuclear import, and its incorporation into virus particles, despite its localization in the cytoplasm, suggested that the structural integrity of helical domains is critical for Vpx functions.	Isoleucine	39-42	vpx protein	Simian immunodeficiency virus	91-94
15572376-6	2005	Unique residues within helices 3 (Ile(164) and Asn(165)), 5 (Cys(202) and His(203)), and 7 (Phe(234) and Phe(238)) were found control the selectivity for CAR activators and inhibitors.	Isoleucine	34-37	nuclear receptor subfamily 1 group I member 3	Homo sapiens	154-157
15667216-9	2005	Backbone dynamics of the thrombin-binding residues Tyr 413 and Ile 414 are inversely correlated with thrombin binding.	Isoleucine	63-66	coagulation factor II, thrombin	Homo sapiens	25-33
15598653-8	2005	Also, alteration of the Ile-144 and Ile-86 residues to the corresponding residues found in the homologous Imp1 protease changes the specificity to promote cleavage following a -1 Asn residue.	Isoleucine	24-27	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	106-110
15598653-8	2005	Also, alteration of the Ile-144 and Ile-86 residues to the corresponding residues found in the homologous Imp1 protease changes the specificity to promote cleavage following a -1 Asn residue.	Isoleucine	36-39	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	106-110
15667216-9	2005	Backbone dynamics of the thrombin-binding residues Tyr 413 and Ile 414 are inversely correlated with thrombin binding.	Isoleucine	63-66	coagulation factor II, thrombin	Homo sapiens	101-109
15667216-10	2005	The preordering of the backbone of Tyr 413 and Ile 414 only occurs in the two-domain fragments, revealing a role for the fourth domain in thrombin binding as well as in anticoagulant cofactor activity.	Isoleucine	47-50	coagulation factor II, thrombin	Homo sapiens	138-146
15507442-2	2005	The recently solved crystal structures of the AID-Ca(V)beta complex in Ca(V)1.1/1.2 have revealed that this interaction occurs through a set of six mostly invariant residues Glu/Asp(6), Leu(7), Gly(9), Tyr(10), Trp(13), and Ile(14) (where the superscript refers to the position of the residue starting with the QQ signature doublet) distributed among three alpha-helical turns in the proximal section of the I-II linker.	Isoleucine	224-227	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	71-83
15581601-4	2005	In this report, we propose that three more residues in 15-PGDH, Ile-17, Asn-91, and Val-186, are also involved in the interaction with NAD(+).	Isoleucine	64-67	carbonyl reductase 1	Homo sapiens	55-62
15581601-14	2005	These results suggest that Ile-17, Asn-91, and Val-186 are involved in the interaction with NAD(+) and contribute to the full catalytic activity of 15-PGDH.	Isoleucine	27-30	carbonyl reductase 1	Homo sapiens	148-155
15640355-2	2005	By specific ligation of pyruvate with the alternative acceptor substrates 2-ketobutyrate and pyruvate, AHAS controls the flux through this branch point and determines the relative rates of synthesis of isoleucine, valine, and leucine, respectively.	Isoleucine	202-212	ilvB acetolactate synthase like	Homo sapiens	103-107
16370485-8	2005	The beta-globin gene sequence was normal but the alpha2-globin gene sequence revealed an ATG-->ATA transition at codon 32, changing the methionine into an isoleucine residue.	Isoleucine	155-165	hemoglobin subunit alpha 2	Homo sapiens	49-62
15389808-3	2005	To determine the association of the HER-2 gene with Japanese sporadic Pca, we analyzed the frequency of codon 655 (A/G, isoleucine, or valine) in case and control group.	Isoleucine	120-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-41
15715267-12	2005	The heating of As(V) in the presence of gluconate, glucose, ascorbic acid, methionine, isoleucine, sodium chloride, and pure water, in autoclave for 15 minutes, showed that, whereas no As(III) was found in pure water and sodium chloride solution, approximately 50% of As(V) was converted into As(III) in the remainder of the solutions.	Isoleucine	87-97	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-20
15821880-0	2005	The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana.	Isoleucine	108-118	branched-chain amino acid transaminase 1	Arabidopsis thaliana	51-59
15485863-4	2004	Alanine was by far the strictest requirement, because no residue could fully substitute for it in the case of HIF-P4H-1, and only serine or isoleucine, valine, and serine did this in the cases of HIF-P4Hs 2 and 3.	Isoleucine	140-150	egl-9 family hypoxia inducible factor 3	Homo sapiens	196-212
15471876-4	2004	Although both human and B. subtilis enzymes normally have Asp at position 87 (or 69), the B. subtilis ASL has Ile and Asp at 62 and 65, respectively, whereas human ASL has Glu and Arg at the equivalent positions.	Isoleucine	110-113	adenylosuccinate lyase	Homo sapiens	102-105
15475353-6	2004	A single mutation (Ile(315(6.53)) to Thr) in TMD VI of V1aR increased the sensitivity for VT, while a single mutation (Phe(313(6.51)) to Tyr or Pro(334(7.33)) to Thr) reduced sensitivity toward AVP.	Isoleucine	19-22	arginine vasopressin receptor 1A	Rattus norvegicus	55-59
15475353-7	2004	Interestingly the triple mutation (Phe(313(6.51)) to Tyr, Ile(6.53) to Thr, and Pro(7.33) to Thr) of V1aR increased sensitivity to VT but greatly reduced sensitivity to AVP, behaving like bfVT1R.	Isoleucine	58-61	arginine vasopressin receptor 1A	Rattus norvegicus	101-105
15475353-9	2004	These results suggest that Phe/Tyr(6.51), Ile/Thr(6.53), and Pro/Thr(7.33) are responsible for the differential ligand selectivity between rat V1aR and bfVT1R.	Isoleucine	42-45	arginine vasopressin receptor 1A	Rattus norvegicus	143-147
15492928-4	2004	Two of these result in a truncated CHEK2 protein, and the other is a missense substitution of an isoleucine for a threonine.	Isoleucine	97-107	checkpoint kinase 2	Homo sapiens	35-40
15630560-2	2004	The methodology is applied to protein L and malate synthase G. Average (13)C CSA values are considerably smaller for Ile than Leu/Val (17 vs 25 ppm) and are in good agreement with previous solid state NMR studies of powders of amino acids and dipeptides and in reasonable agreement with quantum-chemical DFT calculations of methyl carbon CSA values in peptide fragments.	Isoleucine	117-120	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	77-80
15618620-4	2004	Substitution of L524 of Escherichia coli GroEL with the corresponding residue (isoleucine) from psychrophilic GroEL resulted in a GroE with approximately wild-type activity at 25 degrees C, but also at 10 degrees C, a temperature at which wild-type E. coli GroE is inactive.	Isoleucine	79-89	GroEL	Escherichia coli	41-46
15618620-4	2004	Substitution of L524 of Escherichia coli GroEL with the corresponding residue (isoleucine) from psychrophilic GroEL resulted in a GroE with approximately wild-type activity at 25 degrees C, but also at 10 degrees C, a temperature at which wild-type E. coli GroE is inactive.	Isoleucine	79-89	GroEL	Escherichia coli	110-115
15630560-2	2004	The methodology is applied to protein L and malate synthase G. Average (13)C CSA values are considerably smaller for Ile than Leu/Val (17 vs 25 ppm) and are in good agreement with previous solid state NMR studies of powders of amino acids and dipeptides and in reasonable agreement with quantum-chemical DFT calculations of methyl carbon CSA values in peptide fragments.	Isoleucine	117-120	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	338-341
15557098-4	2004	The point mutation in tam replaced a conserved threonine with an isoleucine in the linker region between the alpha4 and alpha5 helices of the first cyclin fold.	Isoleucine	65-75	cyclin	Arabidopsis thaliana	148-154
15469317-1	2004	[reaction: see text] L-alpha-(1-Cyclobutenyl)glycine (1-Cbg) was targeted as a potentially translatable analogue of isoleucine and valine and as a useful building block for peptides.	Isoleucine	116-126	serpin family A member 6	Homo sapiens	56-59
15537355-1	2004	This paper reports the synthesis of two angiotensin II analogues with tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics replacing the Tyr(4)-Ile(5) residues.	Isoleucine	167-170	angiotensinogen	Homo sapiens	40-54
15491611-7	2004	Molecular modeling identified three residues in the core region of SF2 Nef (Ala83, His116, and Tyr120) which are substituted in ELI with Glu, Asn, and Ile, respectively.	Isoleucine	151-154	serine and arginine rich splicing factor 1	Homo sapiens	67-70
15491611-7	2004	Molecular modeling identified three residues in the core region of SF2 Nef (Ala83, His116, and Tyr120) which are substituted in ELI with Glu, Asn, and Ile, respectively.	Isoleucine	151-154	S100 calcium binding protein B	Homo sapiens	71-74
15491611-8	2004	Two of these residues (Ala83 and Tyr120) form part of the hydrophobic pocket that contacts Ile 96 in the RT loop of the Hck SH3 domain in the Nef-SH3 crystal structure.	Isoleucine	91-94	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
15491611-8	2004	Two of these residues (Ala83 and Tyr120) form part of the hydrophobic pocket that contacts Ile 96 in the RT loop of the Hck SH3 domain in the Nef-SH3 crystal structure.	Isoleucine	91-94	S100 calcium binding protein B	Homo sapiens	142-145
15632312-5	2004	Among them, three mAbs that strongly reacted with yeast Hsc82 recognized Asn(291)-Ile(304), a conserved region of the family protein.	Isoleucine	82-85	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	56-61
15485485-5	2004	The decrease in surface expression of the hNET isoforms is probably a consequence of the lack of the three amino acids leucine, alanine and isoleucine at the C-terminal end which may represent a motif facilitating cell surface expression of the hNET.	Isoleucine	140-150	solute carrier family 6 member 2	Homo sapiens	42-46
15485485-5	2004	The decrease in surface expression of the hNET isoforms is probably a consequence of the lack of the three amino acids leucine, alanine and isoleucine at the C-terminal end which may represent a motif facilitating cell surface expression of the hNET.	Isoleucine	140-150	solute carrier family 6 member 2	Homo sapiens	245-249
15684686-5	2004	The current experiments analyze the interactions of isolated human neutrophils with PEG hydrogels modified with Arg-Gly-Asp-Ser (RGDS), a known ligand for some beta(1) and beta(3) integrins, and Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Thr-Ile-Gly-Gly (TMKIIPFNRLTIGG), a ligand for Mac-1, a beta(2) integrin.	Isoleucine	207-210	ral guanine nucleotide dissociation stimulator	Homo sapiens	129-133
15469317-3	2004	1-Cbg was found to substitute efficiently for isoleucine and valine, but not leucine, in the translation of green fluorescent protein in vitro.	Isoleucine	46-56	serpin family A member 6	Homo sapiens	2-5
15165996-6	2004	System A transports Pro, Ala, His, Asn, Ser, and Gln; system ASC transports Ser, Gly, Met, Val, Leu, Ile, Cys, and Thr; system N transports Gln, His, Ser, and Asn; Na+ -LNAA transports Leu, Ile, Val, Trp, Tyr, Phe, Met, Ala, His, Thr, and Gly.	Isoleucine	101-104	PYD and CARD domain containing	Homo sapiens	61-64
15453706-0	2004	ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [beta-CN f(47-51)].	Isoleucine	69-72	angiotensin I converting enzyme	Homo sapiens	0-3
15233625-5	2004	The free side chain of lysine, replacing the isoleucine residue at P6 position in the angiotensinogen sequence, contributed to the increased value for k(cat).	Isoleucine	45-55	angiotensinogen	Homo sapiens	86-101
15271993-12	2004	Consequently, we suggest that Ala(169) and Ile(172) of human SERT are important residues in sensing the N-methylation state of SERT antagonists.	Isoleucine	43-46	solute carrier family 6 member 4	Homo sapiens	61-65
15271993-12	2004	Consequently, we suggest that Ala(169) and Ile(172) of human SERT are important residues in sensing the N-methylation state of SERT antagonists.	Isoleucine	43-46	solute carrier family 6 member 4	Homo sapiens	127-131
15336531-4	2004	When starved rats received intraperitoneal injections of valine, leucine or isoleucine, only leucine treatment increased both hepatic and circulating levels of HGF in a dose-dependent manner, up to 1.5 and 2.3 times higher, respectively, than in controls.	Isoleucine	76-86	hepatocyte growth factor	Rattus norvegicus	160-163
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	48-51	angiogenin	Homo sapiens	62-65
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	48-51	angiogenin	Homo sapiens	62-65
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	48-51	angiogenin	Homo sapiens	62-65
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	48-51	angiogenin	Homo sapiens	62-65
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	55-58	angiogenin	Homo sapiens	62-65
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	55-58	angiogenin	Homo sapiens	62-65
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	55-58	angiogenin	Homo sapiens	62-65
15901848-6	2005	It is surprising that the Ang II analog [Sar(1),Ile(4),Ile(8)]Ang II and the native angiotensin II fragments Ang 1-7, Ang IV, and Ang 5-8, which are inactive in activating the wild-type receptor, activated N295S and L305Q.	Isoleucine	55-58	angiogenin	Homo sapiens	62-65
15356339-9	2004	The accuracy of the specificity determination allows identification of an important difference in peptide specificity between these closely related kinases; Ile/Leu at the P-1 position is disfavored by PKC-zeta but not PKC-delta.	Isoleucine	157-160	protein kinase C zeta	Homo sapiens	202-210
15245332-3	2004	Kinetic characterization and oxaloacetate partition ratio of the NADP(+)-ME K255I (Lys-255-->Ile) mutant suggest that the mutated lysine residue is implicated in catalysis and substrate binding.	Isoleucine	96-99	NADP-dependent malic enzyme	Zea mays	65-75
15247292-6	2004	Amino acid sequencing and compositional analysis identified the NAD(+)-binding site of UGDH as the region containing the sequence ICCIGAXYVGGPT, corresponding to Ile-7 through Thr-19 of the amino acid sequence of human UGDH.	Isoleucine	162-165	UDP-glucose 6-dehydrogenase	Homo sapiens	87-91
15247212-8	2004	Alanine-scanning mutagenesis of the GLUT4 amino terminus demonstrated that Phe(5) and Ile(8) within the FQQI motif and, to a lesser extent, Asp(12)/Gly(13) were necessary for the appropriate initial trafficking following biosynthesis.	Isoleucine	86-89	solute carrier family 2 member 4	Homo sapiens	36-41
15247292-6	2004	Amino acid sequencing and compositional analysis identified the NAD(+)-binding site of UGDH as the region containing the sequence ICCIGAXYVGGPT, corresponding to Ile-7 through Thr-19 of the amino acid sequence of human UGDH.	Isoleucine	162-165	UDP-glucose 6-dehydrogenase	Homo sapiens	219-223
15151997-6	2004	This deficit appears to be compensated by a more dominant role of Ile-330 in human CAR over Leu-340 in mouse CAR because it is more efficient than Cys-347 in controlling the flexibility of helix 12 in the presence of an agonist.	Isoleucine	66-69	nuclear receptor subfamily 1 group I member 3	Homo sapiens	83-86
15229879-9	2004	The results show that CA(N) residues His87-Ala-Gly-Pro-Ile-Ala92 form the majority of the interactions with CypA residues.	Isoleucine	55-58	peptidylprolyl isomerase A	Homo sapiens	108-112
15289616-2	2004	We show that all four subunits of the arginine repressor are recruited to ARG1 by Gcn4p in cells replete with arginine but starved for isoleucine/valine.	Isoleucine	135-145	arginase 1	Homo sapiens	74-78
15304014-2	2004	This novel allele, designated as DRB1*1145, differs from DRB1*1123 in one nucleotide at position 199 in exon 2 (A replacing T), leading to one amino acid change from phenylalanine (Phe) to isoleucine (Ile) at codon 67.	Isoleucine	189-199	major histocompatibility complex, class II, DR beta 1	Homo sapiens	33-37
15304014-2	2004	This novel allele, designated as DRB1*1145, differs from DRB1*1123 in one nucleotide at position 199 in exon 2 (A replacing T), leading to one amino acid change from phenylalanine (Phe) to isoleucine (Ile) at codon 67.	Isoleucine	189-199	major histocompatibility complex, class II, DR beta 1	Homo sapiens	57-61
15304014-2	2004	This novel allele, designated as DRB1*1145, differs from DRB1*1123 in one nucleotide at position 199 in exon 2 (A replacing T), leading to one amino acid change from phenylalanine (Phe) to isoleucine (Ile) at codon 67.	Isoleucine	201-204	major histocompatibility complex, class II, DR beta 1	Homo sapiens	33-37
15304014-2	2004	This novel allele, designated as DRB1*1145, differs from DRB1*1123 in one nucleotide at position 199 in exon 2 (A replacing T), leading to one amino acid change from phenylalanine (Phe) to isoleucine (Ile) at codon 67.	Isoleucine	201-204	major histocompatibility complex, class II, DR beta 1	Homo sapiens	57-61
15123647-2	2004	Granzyme B prefers substrates containing P4 to P1 amino acids Ile/Val, Glu/Met/Gln, Pro/Xaa, and aspartic acid N-terminal to the proteolytic cleavage.	Isoleucine	62-65	granzyme B	Homo sapiens	0-10
15254763-1	2004	GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V).	Isoleucine	131-141	glutathione S-transferase pi 1	Homo sapiens	0-5
15223302-6	2004	On the basis of secondary structure predictions, it was hypothesized that the amino acid motifs Pro-Ile-Gly of mUcnII and Pro-Thr-Asn of mUcnIII decrease alpha-helicity and thereby impair binding to CRF1.	Isoleucine	100-103	corticotropin releasing hormone receptor 1	Homo sapiens	199-203
15265078-5	2004	This nucleotide transversion results in an alteration of codon 299 from AAC to ATC, which leads to a change from asparagine (Asn) to isoleucine (Ile) in the POU domain of POU1F1.	Isoleucine	133-143	POU class 1 homeobox 1	Gallus gallus	171-177
15265078-5	2004	This nucleotide transversion results in an alteration of codon 299 from AAC to ATC, which leads to a change from asparagine (Asn) to isoleucine (Ile) in the POU domain of POU1F1.	Isoleucine	145-148	POU class 1 homeobox 1	Gallus gallus	171-177
15254213-4	2004	The mutation of amino acid 129 to isoleucine greatly increased the LMP-1 half-life.	Isoleucine	34-44	PDZ and LIM domain 7	Homo sapiens	67-72
15172637-3	2004	In this study, we constructed an expression vector expressing mutant type p27Kip1 gene (pcDNA3.1-p27Kip1 mt), with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC), which is not influenced by ubiquitin-mediated degradation.	Isoleucine	163-166	cyclin dependent kinase inhibitor 1B	Homo sapiens	74-81
15258265-7	2004	Expression of wild-type JAR1 in transgenic jar1-1 plants restored sensitivity to JA and elevated JA-Ile to the same level as in the wild type.	Isoleucine	100-103	Auxin-responsive GH3 family protein	Arabidopsis thaliana	24-28
15258265-7	2004	Expression of wild-type JAR1 in transgenic jar1-1 plants restored sensitivity to JA and elevated JA-Ile to the same level as in the wild type.	Isoleucine	100-103	Auxin-responsive GH3 family protein	Arabidopsis thaliana	43-47
15123688-5	2004	Our results show the importance of residues Ser-181, Met-182 in H3, Leu-219, Leu-220 and Arg-226 in H5, Ile-338 in H10, and Ile-346 in H11 that line the ligand-binding domain pocket in HNF-4alpha and impair its transactivation potential.	Isoleucine	104-107	H1.0 linker histone	Homo sapiens	115-118
15210149-2	2004	Homoserine dehydrogenase, which reduces aspartate semi-aldehyde to homoserine in a NAD(P)H-dependent reaction, is one such target that is required for the biosynthesis of Met, Thr, and Ile from Asp.	Isoleucine	185-188	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	0-24
15293602-4	2004	Sequencing of genomic DNA detected a de novo heterozygous missense mutation of the SFTPC gene (g.1286T>C) resulting in a substitution of threonine for isoleucine (173T) in the C-terminal propeptide.	Isoleucine	151-161	surfactant protein C	Homo sapiens	83-88
15236578-7	2004	This observation is inconsistent with a rhodopsin-like structure, which would locate Ile(234) on the lipid-exposed side of TM5, too distant from other residues making up the Zn(2+)-binding site.	Isoleucine	85-88	rhodopsin	Rattus norvegicus	40-49
15163523-3	2004	GSTP1 exon 5 gene presents a single-nucleotide polymorphism (a to g) that results into an amino-acid substitution (Ile to Val).	Isoleucine	115-118	glutathione S-transferase pi 1	Homo sapiens	0-5
15128923-1	2004	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism that affects the catabolism of isoleucine and ketone bodies.	Isoleucine	119-129	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38
15039446-7	2004	Furthermore, the results presented indicate that residues in the second peptide (Glu-64, Asn-65, and Ile-68) participate in IL-2Rbeta recruitment.	Isoleucine	101-104	interleukin 2 receptor subunit beta	Homo sapiens	124-133
15163798-5	2004	Ablating the editing activity of isoleucyl-tRNA synthetase resulted in an ambiguous code in which, through supplementation of a limited supply of isoleucine with an alternative amino acid that was noncoding, the mutant generating statistical proteins was favored over the wild-type isogenic strain.	Isoleucine	146-156	isoleucyl-tRNA synthetase 1	Homo sapiens	33-58
15128805-4	2004	The structures confirm the presence of primary anchor residues P2-Ile/-Val and P9-/P10-Lys, and also clearly reveal the presence of secondary anchor residues P6-Ser for reverse transcriptase and P7-Met for Nef.	Isoleucine	66-69	S100 calcium binding protein B	Homo sapiens	206-209
15104685-7	2004	The new DRB1*1140 is identical to DRB1*1116, except for a single nucleotide substitution at codon 67 from ATC (encoding for isoleucine) to TTC (encoding for phenylalanine).	Isoleucine	124-134	major histocompatibility complex, class II, DR beta 1	Homo sapiens	8-12
14741044-5	2004	Homology modelling of furin"s pro-region revealed that residues Ile-60 and His-66 might be crucial in forming the binding interface with the catalytic domain, while residues Trp-34 and Phe-67 might be involved in maintaining a hydrophobic core within the pro-region itself.	Isoleucine	64-67	furin, paired basic amino acid cleaving enzyme	Homo sapiens	22-27
15104685-7	2004	The new DRB1*1140 is identical to DRB1*1116, except for a single nucleotide substitution at codon 67 from ATC (encoding for isoleucine) to TTC (encoding for phenylalanine).	Isoleucine	124-134	major histocompatibility complex, class II, DR beta 1	Homo sapiens	34-38
15039300-4	2004	Here, we report the isolation of a mutant clone of the human UGT1A10, at position 211 of the protein, where a threonine residue replaces an isoleucine residue (allele Thr211).	Isoleucine	140-150	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	61-68
15604669-4	2004	TD assays and growth resistance to the isoleucine (Ile) toxic analog -O-methylthreonine (OMT) confirmed the desensitization to feedback inhibition and the viability of these mutant omr1 alleles as selectable markers, respectively.	Isoleucine	51-54	L-O-methylthreonine resistant 1	Arabidopsis thaliana	181-185
15604669-5	2004	Two of the site-directed mutants, omr1-5 and omr1-7 , appeared to influence one of the two separate Ile-binding sites and had a notable 13-fold and 15-fold increase in free Ile, respectively.	Isoleucine	100-103	L-O-methylthreonine resistant 1	Arabidopsis thaliana	34-51
15604669-5	2004	Two of the site-directed mutants, omr1-5 and omr1-7 , appeared to influence one of the two separate Ile-binding sites and had a notable 13-fold and 15-fold increase in free Ile, respectively.	Isoleucine	173-176	L-O-methylthreonine resistant 1	Arabidopsis thaliana	34-51
15604669-6	2004	The omr1-8 appeared to influence the other Ile-binding site and resulted in a 2-fold increase in free Ile.	Isoleucine	43-46	L-O-methylthreonine resistant 1	Arabidopsis thaliana	4-10
15604669-7	2004	The transgenic omr1-1 double mutant affecting both Ile-binding sites, however, displayed a 106-fold increase in free Ile revealing a profound synergistic interplay between these separate Ile-binding sites.	Isoleucine	51-54	L-O-methylthreonine resistant 1	Arabidopsis thaliana	15-21
15604669-7	2004	The transgenic omr1-1 double mutant affecting both Ile-binding sites, however, displayed a 106-fold increase in free Ile revealing a profound synergistic interplay between these separate Ile-binding sites.	Isoleucine	117-120	L-O-methylthreonine resistant 1	Arabidopsis thaliana	15-21
15604669-7	2004	The transgenic omr1-1 double mutant affecting both Ile-binding sites, however, displayed a 106-fold increase in free Ile revealing a profound synergistic interplay between these separate Ile-binding sites.	Isoleucine	117-120	L-O-methylthreonine resistant 1	Arabidopsis thaliana	15-21
15133116-6	2004	The ilv2 mutants were auxotrophic for isoleucine and valine and the auxotrophy was satisfied by these amino acids only when proline, and not ammonium, was the nitrogen source, indicating nitrogen regulation of amino acid transport.	Isoleucine	38-48	acetolactate synthase catalytic subunit	Saccharomyces cerevisiae S288C	4-8
15133116-7	2004	ilv2 mutants rapidly lost viability at 37 degrees C and when starved for isoleucine and valine.	Isoleucine	73-83	acetolactate synthase catalytic subunit	Saccharomyces cerevisiae S288C	0-4
15039300-5	2004	Because the isoleucine is conserved among many UGT1A isoforms, we proceeded to the analysis of the activity of the wild-type UGT1A10 (T211I) and compared it with that of the variant enzyme (I211T(*)).	Isoleucine	12-22	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	47-52
15039300-5	2004	Because the isoleucine is conserved among many UGT1A isoforms, we proceeded to the analysis of the activity of the wild-type UGT1A10 (T211I) and compared it with that of the variant enzyme (I211T(*)).	Isoleucine	12-22	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	125-132
15039300-6	2004	In vitro assays with microsomal extracts from stably expressing human embryonic kidney 293 (HEK293) cells showed that the mutant enzyme lost all detectable activity toward major substrates, which demonstrate that the residue isoleucine at position 211 is essential for UGT1A10 activity.	Isoleucine	225-235	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	269-276
14670966-6	2004	Mutational analysis of the five divergent amino acids in EL2 between the two receptors revealed that three amino acids, Asn-177, Ile-183, and Leu-190, contribute to the capacity of EL2 to impart ATP agonism.	Isoleucine	129-132	spectrin alpha, erythrocytic 1	Homo sapiens	57-60
15047829-4	2004	Thus, the macaque coreceptor engineered to contain the natural human CCR5 residue (isoleucine) at position 198 is sensitive to HIV-1 entry inhibition by SCH-C, whereas a human CCR5 mutant containing the corresponding macaque residue (methionine) is resistant.	Isoleucine	83-93	C-C motif chemokine receptor 5	Homo sapiens	69-73
15047829-7	2004	However, the binding of a conformation-dependent monoclonal antibody to human CCR5 is inhibited by SCH-C only when residue 198 is isoleucine.	Isoleucine	130-140	C-C motif chemokine receptor 5	Homo sapiens	78-82
15053768-7	2004	The conserved threonine in the motif was substituted by isoleucine in the 15th and 12th PPR motifs in pgr3-1 and pgr3-2, respectively, and the conserved leucine by phenylalanine in the final incomplete motif of pgr3-3.	Isoleucine	56-66	proton gradient regulation 3	Arabidopsis thaliana	102-106
15053768-7	2004	The conserved threonine in the motif was substituted by isoleucine in the 15th and 12th PPR motifs in pgr3-1 and pgr3-2, respectively, and the conserved leucine by phenylalanine in the final incomplete motif of pgr3-3.	Isoleucine	56-66	proton gradient regulation 3	Arabidopsis thaliana	113-117
15053768-7	2004	The conserved threonine in the motif was substituted by isoleucine in the 15th and 12th PPR motifs in pgr3-1 and pgr3-2, respectively, and the conserved leucine by phenylalanine in the final incomplete motif of pgr3-3.	Isoleucine	56-66	proton gradient regulation 3	Arabidopsis thaliana	113-117
14670966-6	2004	Mutational analysis of the five divergent amino acids in EL2 between the two receptors revealed that three amino acids, Asn-177, Ile-183, and Leu-190, contribute to the capacity of EL2 to impart ATP agonism.	Isoleucine	129-132	spectrin alpha, erythrocytic 1	Homo sapiens	181-184
15001703-9	2004	Taking together prior mutational studies and the NMR structure of Ost4p, we propose that in the OT complex Stt3p is packed against the alpha 2-helix of Ost4p by using a "ridges-into-grooves" model, with Met-18, Leu-21, and Ile-24 as the packing interface on one face, whereas Ost3p is involved in interactions with Met-19, Thr-20, Ile-22, and Val-23 on the other face.	Isoleucine	223-226	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	107-112
15001703-9	2004	Taking together prior mutational studies and the NMR structure of Ost4p, we propose that in the OT complex Stt3p is packed against the alpha 2-helix of Ost4p by using a "ridges-into-grooves" model, with Met-18, Leu-21, and Ile-24 as the packing interface on one face, whereas Ost3p is involved in interactions with Met-19, Thr-20, Ile-22, and Val-23 on the other face.	Isoleucine	331-334	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	107-112
14701815-8	2004	Once bound to the protease active site, SP6(EVC/S) partitions with equal probability to undergo proteolysis by NS3 at the C-terminal site of the engineered RSL, (P(6))Glu-Ile-(P(4))Val-Met-Thr-(P(1))Cys- downward arrow -(P(1)")Ser, or to form a covalent acyl-enzyme complex characteristic of cognate protease-serpin pairs.	Isoleucine	171-174	Sp6 transcription factor	Homo sapiens	40-43
14673650-5	2004	A structural analog of Ile, l-O-methylthreonine (OMT), is able to compete effectively with Ile during translation and induce cell death.	Isoleucine	23-26	caffeic acid 3-O-methyltransferase-like	Nicotiana tabacum	49-52
14978285-6	2004	Among residues constituting the interface, Phe-34, Ser-36A, Leu-65, Tyr-76, Arg-77A, Ile-82, and Lys-110 of thrombin and the A alpha chain Trp-33, Phe-35, Asp-38, Glu-39, the B beta chain Ala-68 and Asp-69, and the gamma chain Asp-27 and Ser-30 of E(ht) form a net of polar contacts surrounding a well defined hydrophobic interior.	Isoleucine	85-88	coagulation factor II, thrombin	Homo sapiens	108-116
15134871-5	2004	NEP cleaved substance P (SP) at Gln(6)-Phe(7), Phe(7)[see text]-Phe(8), and Gly(9)-Leu(10) and neurotensin (NT) at Pro(10)-Tyr(11) and Tyr(11)-Ile(12).	Isoleucine	143-146	membrane metalloendopeptidase	Homo sapiens	0-3
15134871-10	2004	ACE hydrolyzed NT at Tyr(11)-Ile(12) to release Ile(12)-Leu(13).	Isoleucine	29-32	angiotensin I converting enzyme	Homo sapiens	0-3
15134871-10	2004	ACE hydrolyzed NT at Tyr(11)-Ile(12) to release Ile(12)-Leu(13).	Isoleucine	48-51	angiotensin I converting enzyme	Homo sapiens	0-3
14673650-5	2004	A structural analog of Ile, l-O-methylthreonine (OMT), is able to compete effectively with Ile during translation and induce cell death.	Isoleucine	91-94	caffeic acid 3-O-methyltransferase-like	Nicotiana tabacum	49-52
15011833-8	2004	METHODOLOGY: In this study, we focused our aim on the degradation of p27kip1 protein mediated by a recombinant adenoviral expressing a mutant p27kip1 (Adp27-mt), which has a mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC).	Isoleucine	222-225	cyclin dependent kinase inhibitor 1B	Homo sapiens	142-149
15019526-6	2004	Interestingly, two other structurally related peptides from Drosophila--ETH2 and capa-1--which feature conservative changes (Ile and Val, respectively) at the C-terminal Leu position, were inactive within a physiological range of concentrations.	Isoleucine	125-128	Ecdysis triggering hormone	Drosophila melanogaster	72-76
15019526-6	2004	Interestingly, two other structurally related peptides from Drosophila--ETH2 and capa-1--which feature conservative changes (Ile and Val, respectively) at the C-terminal Leu position, were inactive within a physiological range of concentrations.	Isoleucine	125-128	Capability	Drosophila melanogaster	81-87
14661034-0	2004	Mutation of a highly conserved isoleucine disrupts hydrophobic interactions in the alpha beta spectrin self-association binding site.	Isoleucine	31-41	karst	Drosophila melanogaster	94-102
14661034-7	2004	Molecular modeling demonstrated that replacement of a hydrophobic isoleucine with a hydrophilic threonine disrupts highly conserved hydrophobic interactions in the interior of the spectrin triple helix critical for spectrin function.	Isoleucine	66-76	karst	Drosophila melanogaster	180-188
14661034-7	2004	Molecular modeling demonstrated that replacement of a hydrophobic isoleucine with a hydrophilic threonine disrupts highly conserved hydrophobic interactions in the interior of the spectrin triple helix critical for spectrin function.	Isoleucine	66-76	karst	Drosophila melanogaster	215-223
14684173-1	2004	Branched-chain amino acid (BCAA: Leu, Ile, and Val) mixture has been used for treatment of hypoalbuminemia in patients with decompensated liver cirrhosis in Japan.	Isoleucine	38-41	AT-rich interaction domain 4B	Homo sapiens	27-31
14989718-2	2004	Sequencing of exons 2 and 3 revealed that the HLA-B*1580 differs from its closest matching allele B*1518 by two substitutions in exon 3, leading to two amino acid changes, threonine to isoleucine and leucine to isoleucine at codons 94 and 95, respectively.	Isoleucine	185-195	major histocompatibility complex, class I, B	Homo sapiens	46-51
14989718-2	2004	Sequencing of exons 2 and 3 revealed that the HLA-B*1580 differs from its closest matching allele B*1518 by two substitutions in exon 3, leading to two amino acid changes, threonine to isoleucine and leucine to isoleucine at codons 94 and 95, respectively.	Isoleucine	211-221	major histocompatibility complex, class I, B	Homo sapiens	46-51
14698416-2	2004	The three polymorphisms under investigation were an Arg --> Gln substitution at codon 399 in exon 10 of XRCC1, a Thr --> Met substitution at codon 241 in exon 7 of XRCC3 and an Ile --> Thr substitution at codon 401 in exon 4 of XRCC4.	Isoleucine	183-186	X-ray repair cross complementing 1	Homo sapiens	107-112
14684914-1	2004	Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) catalyses the formation of 2-acetolactate and 2-aceto-2-hydroxybutyrate as the first step in the biosynthesis of the branched-chain amino acids valine, leucine and isoleucine.	Isoleucine	209-219	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	0-25
14684914-1	2004	Acetohydroxyacid synthase (AHAS; EC 2.2.1.6) catalyses the formation of 2-acetolactate and 2-aceto-2-hydroxybutyrate as the first step in the biosynthesis of the branched-chain amino acids valine, leucine and isoleucine.	Isoleucine	209-219	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	27-31
15011833-8	2004	METHODOLOGY: In this study, we focused our aim on the degradation of p27kip1 protein mediated by a recombinant adenoviral expressing a mutant p27kip1 (Adp27-mt), which has a mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC).	Isoleucine	222-225	cyclin dependent kinase inhibitor 1B	Homo sapiens	69-76
14709845-7	2003	By PCR direct sequencing, homozygous Trp (8) Arg and Ile (15) Thr mutations in exon 2 of LH beta were detected.	Isoleucine	53-56	luteinizing hormone subunit beta	Homo sapiens	89-96
14527946-10	2003	Chemical shift perturbation protein NMR experiments showed that FabG-ACP interactions occurred along the length of ACP helix alpha2 and extended into the adjacent loop-2 region to involve Ile-54.	Isoleucine	188-191	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	64-68
14527946-10	2003	Chemical shift perturbation protein NMR experiments showed that FabG-ACP interactions occurred along the length of ACP helix alpha2 and extended into the adjacent loop-2 region to involve Ile-54.	Isoleucine	188-191	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	69-72
14714554-7	2003	In our experimental conditions, L-isoleucine, described to stimulate beta-defensin in bovine epithelial cells, did not exert any effect either on hBD-2 and hBD-3 transcripts or MIP-3alpha protein.	Isoleucine	32-44	LOC100296173	Bos taurus	69-82
14596591-2	2003	In native insulin, the invariant Ile(A2) side chain anchors the N-terminal alpha-helix of the A-chain to the hydrophobic core.	Isoleucine	33-36	insulin	Homo sapiens	10-17
14646971-2	2003	We previously identified a missense mutation, methionine (ATG) to isoleucine (ATC) at nucleotide 1023 (M341I), in exon 3 of the human natriuretic peptide receptor A type (hNPRA) gene.	Isoleucine	66-76	natriuretic peptide receptor 1	Homo sapiens	171-176
14678807-5	2003	A novel homozygous G-to-A mutation (128933G-->A) in exon 7 changing a valine to isoleucine (V367I) in the epimerase domain of the GNE gene was found.	Isoleucine	83-93	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	133-136
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Isoleucine	105-108	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	20-25
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Isoleucine	105-108	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	50-55
14642782-5	2003	Caspase-8 activity was increased at 12 and 24 h after injury and IETD-CHO, (Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO, CHO is aldehyde) a cell permeable caspase-8 inhibitor, given by i.c.v.	Isoleucine	131-134	caspase-8	Cricetulus griseus	0-9
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Isoleucine	105-108	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	117-122
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Isoleucine	105-108	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	227-232
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Isoleucine	168-171	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	20-25
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Isoleucine	168-171	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	50-55
14584938-5	2003	The absence of this COX-2 secondary pocket in the COX-1 binding site is due to the presence of the bulky Ile(523) in COX-1 such that access to the amino acid residues (Ile(517), Phe(518), Gln(192), and His(90)), which line the COX-2 secondary pocket with which the SO(2)Me pharmacophore could interact, is hindered.	Isoleucine	168-171	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	117-122
12930836-2	2003	When expressed in Xenopus oocytes, the encoded protein designated LAT3 (L-type amino acid transporter 3) transported neutral amino acids such as l-leucine, l-isoleucine, l-valine, and l-phenylalanine.	Isoleucine	156-168	solute carrier family 43 member 1	Homo sapiens	66-70
14606895-1	2003	The concentration dependence of the pressure- and temperature-induced cloud point transition (Pc and Tc, respectively) of aqueous solutions of an elastin-like polypeptide with a repeating pentapeptide Val-Pro-Gly-Ile-Gly sequence (MGLDGSMG(VPGIG)40VPLE) was investigated by using apparent light scattering, differential scanning calorimetry, and circular dichroism methods.	Isoleucine	213-216	elastin	Homo sapiens	146-153
14523231-4	2003	In one family, we identified a T599 --> A mutation changing an isoleucine into a lysine residue (I200K) within the glycine/serine (GS) domain of BMPR1B, a region involved in phosphorylation of the receptor.	Isoleucine	66-76	bone morphogenetic protein receptor type 1B	Homo sapiens	148-154
14531686-4	2003	Binding-induced (15)N relaxation dispersion of residues Phe(56), Glu(57), Glu(58), and Ile(59) can be fitted phenomenologically to a two-site on-and-off exchange mechanism with physically feasible relaxation and kinetic parameters obtained for residues Phe(56), Glu(58), and Ile(59), independent of the prothrombin concentration.	Isoleucine	87-90	coagulation factor II, thrombin	Homo sapiens	303-314
14531686-4	2003	Binding-induced (15)N relaxation dispersion of residues Phe(56), Glu(57), Glu(58), and Ile(59) can be fitted phenomenologically to a two-site on-and-off exchange mechanism with physically feasible relaxation and kinetic parameters obtained for residues Phe(56), Glu(58), and Ile(59), independent of the prothrombin concentration.	Isoleucine	275-278	coagulation factor II, thrombin	Homo sapiens	303-314
12951082-2	2003	The results indicated that the interaction of the distal hydrophobic tail part of KCL and related derivatives with amino acid residue 272 (isoleucine) in the helix three region of PPARalpha is of primary importance for human-selective PPARalpha activation.	Isoleucine	139-149	peroxisome proliferator activated receptor alpha	Homo sapiens	180-189
12951082-2	2003	The results indicated that the interaction of the distal hydrophobic tail part of KCL and related derivatives with amino acid residue 272 (isoleucine) in the helix three region of PPARalpha is of primary importance for human-selective PPARalpha activation.	Isoleucine	139-149	peroxisome proliferator activated receptor alpha	Homo sapiens	235-244
14500665-8	2003	This study strongly suggested that the extracellular region of Ser(40)-Ile(64) and leucine residues at positions 107, 112, and 115 in a leucine-rich repeat motif of TLR2 are involved in the recognition of mycoplasmal diacylated lipoproteins and lipopeptides and in the recognition of S. aureus peptidoglycans.	Isoleucine	71-74	toll like receptor 2	Homo sapiens	165-169
13680034-1	2003	OBJECTIVE: It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function.	Isoleucine	121-131	adrenoceptor beta 2	Homo sapiens	201-227
13680034-1	2003	OBJECTIVE: It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function.	Isoleucine	121-131	adrenoceptor beta 2	Homo sapiens	229-233
12956767-10	2003	The Ile-325 variant exhibited lower TAFI Ag levels.	Isoleucine	4-7	carboxypeptidase B2	Homo sapiens	36-40
12960553-8	2003	Substitution of Ser270 in TM2 of the alpha subunit by a larger amino acid, tryptophan (W) or isoleucine (I), as in alpha1(S270W)beta 2 gamma 2s and alpha 2(S270I)beta 3 gamma 2s, completely abolished the potentiation of GABA-induced currents by these anesthetic agents.	Isoleucine	93-103	adrenoceptor alpha 1D	Homo sapiens	127-143
12962490-1	2003	A double mutant cycle has been used to evaluate interaction energies between the global stabilizer mutation asparagine 52 --> isoleucine (N52I) in iso-1-cytochrome c and mutations producing single surface histidines at positions 26, 33, 39, 54, 73, 89, and 100.	Isoleucine	129-139	eukaryotic translation initiation factor 1	Homo sapiens	150-155
12962490-1	2003	A double mutant cycle has been used to evaluate interaction energies between the global stabilizer mutation asparagine 52 --> isoleucine (N52I) in iso-1-cytochrome c and mutations producing single surface histidines at positions 26, 33, 39, 54, 73, 89, and 100.	Isoleucine	129-139	cytochrome c, somatic	Homo sapiens	156-168
12908887-7	2003	Isoleucine, leucine, valine and lysine were the EAA with the greatest partitioning towards the mammary gland (up to 36 % of the whole-body flux), which could reflect a potentially limiting effect on milk protein synthesis.	Isoleucine	0-10	Weaning weight-maternal milk	Bos taurus	199-203
12805099-9	2003	The mutation affects the ATG start codon, thereby changing methionine to isoleucine (M1I), and leads to a complete absence of the DDP1 protein.	Isoleucine	73-83	translocase of inner mitochondrial membrane 8A	Homo sapiens	130-134
12917459-6	2003	Among three amino acid differences (positions 60, 61 and 63) in this region, histidine 61 present in human SLAM was most significant, but combined substitutions with this residue and one or both of isoleucine 60 and valine 63 increased further the receptor activity of mouse SLAM.	Isoleucine	198-208	signaling lymphocytic activation molecule family member 1	Homo sapiens	107-111
12733990-4	2003	Cathepsin K preferentially accommodates hydrophobic amino acids with aliphatic side chains (Leu, Ile and Val) in the S2 site.	Isoleucine	97-100	cathepsin K	Homo sapiens	0-11
12956066-5	2003	The choice of NBS or chlorine for allyl halide synthesis is shown to depend on the potential to avoid competing reactions, such as halolactonization of leucine derivatives with chlorine, and hydrogen abstraction and bromine incorporation at multiple sites on treatment of isoleucine derivatives with NBS.	Isoleucine	272-282	nibrin	Homo sapiens	14-17
14533983-6	2003	A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional consequences, was found to delay disease progression but not to reduce infection risk.	Isoleucine	47-57	C-C motif chemokine receptor 2	Homo sapiens	94-99
12924509-5	2003	We detected a mutation (ATG to ATA) in codon 694 in exon 10 of the FMF gene, MEFV, that resulted in a substitution of isoleucine for methionine (M6941) in both her and her father.	Isoleucine	118-128	MEFV innate immuity regulator, pyrin	Homo sapiens	77-81
12853162-1	2003	Examining an association between myocardial infarction (MI) and the Val/Ile polymorphism in the gene for CC chemokine receptor (CCR)2 at the position 64 (CCR2-V64I), 122 MI Czech patients and 277 unrelated control (C) subjects were genotyped by PCR-SSP.	Isoleucine	72-75	C-C motif chemokine receptor 2	Homo sapiens	105-133
12876319-4	2003	Site-directed mutagenesis was utilized to construct amino acid substitutions in B. subtilis adenylosuccinate lyase; Met(10), Ile(123), and Thr(367) were replaced by Leu, Trp, and Arg, respectively, and the altered enzymes were expressed in Escherichia coli.	Isoleucine	125-128	adenylosuccinate lyase	Homo sapiens	92-114
12697764-5	2003	Mutant constructs with bulky hydrophobic residues (valine, isoleucine, or leucine) instead of Trp19 exhibited 30-60% decreases in binding to the tail interacting protein of 47 kDa (Tip47), a protein mediating this transport step, and partially prevented receptor delivery to lysosomes.	Isoleucine	59-69	perilipin 3	Homo sapiens	145-179
12697764-5	2003	Mutant constructs with bulky hydrophobic residues (valine, isoleucine, or leucine) instead of Trp19 exhibited 30-60% decreases in binding to the tail interacting protein of 47 kDa (Tip47), a protein mediating this transport step, and partially prevented receptor delivery to lysosomes.	Isoleucine	59-69	perilipin 3	Homo sapiens	181-186
12853162-1	2003	Examining an association between myocardial infarction (MI) and the Val/Ile polymorphism in the gene for CC chemokine receptor (CCR)2 at the position 64 (CCR2-V64I), 122 MI Czech patients and 277 unrelated control (C) subjects were genotyped by PCR-SSP.	Isoleucine	72-75	C-C motif chemokine receptor 2	Homo sapiens	154-158
12783542-2	2003	5TFI was incorporated into a model target protein, murine dihydrofolate reductase (mDHFR), in an isoleucine auxotrophic Escherichia coli host strain suspended in 5TFI-supplemented minimal medium depleted of isoleucine.	Isoleucine	97-107	dihydrofolate reductase	Mus musculus	83-88
12788102-4	2003	We have recently reported a missense mutation in the adiponectin gene, in which isoleucine at position 164 in the globular domain is substituted with threonine (I164T).	Isoleucine	80-90	adiponectin, C1Q and collagen domain containing	Homo sapiens	53-64
12777626-2	2003	Most of the PH1 alleles detected in the Canary Islands carry the Ile-244 --> Thr (I244T) mutation in the AGXT gene, with 14 of 16 patients homozygous for this mutation.	Isoleucine	65-68	LOW QUALITY PROTEIN: serine--pyruvate aminotransferase	Serinus canaria	108-112
12840230-10	2003	The DING protein (N-terminal amino acid sequence Asp-Ile-Asn-Gly) that binds to genistein with high affinity is one of these.	Isoleucine	53-56	ring finger protein 2	Homo sapiens	4-8
12697759-6	2003	Together these inactivating substitutions identified seven NR1 residues (Ile-385, Gln-387, Glu-388, Thr-500, Asn-502, Ala-696, and Val-717) that undergo proximity-induced covalent coupling with specific regions of the bound antagonist and disclose its mode of docking in the glycine binding pocket of the NMDA receptor.	Isoleucine	73-76	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	59-62
12846420-1	2003	BACKGROUND: Several recent epidemiologic studies examined the association between breast cancer risk and an inherited, single-nucleotide polymorphism in the HER2 gene, codon 655 G to A, which leads to an amino acid substitution of Ile to Val.	Isoleucine	231-234	erb-b2 receptor tyrosine kinase 2	Homo sapiens	157-161
12783542-5	2003	Measurement of the rate of activation of 5TFI by the E. coli isoleucyl-tRNA synthetase (IleRS) yielded a specificity constant (k(cat)/K(m)) 134-fold lower than that for isoleucine.	Isoleucine	169-179	isoleucine-tRNA synthetase 2, mitochondrial	Mus musculus	88-93
12626648-8	2003	Phe-153-->Leu-153 or Ile-433-->Val-433 exchange in hH1R (hH1R-->gpH1R) resulted in poor receptor expression, low [3H]mepyramine affinity, and functional inactivity.	Isoleucine	24-27	histamine receptor H1	Homo sapiens	57-61
12788852-4	2003	In this study, the association of an HNF-1 alpha gene polymorphism, isoleucine (Ile) 27 leucine (Leu), with lipid parameters, in particular with serum HDL-c level, was studied in 356 unrelated Japanese men.	Isoleucine	68-78	HNF1 homeobox A	Homo sapiens	37-48
12626648-12	2003	These differences may be explained by higher conformational flexibility of gpH1R relative to hH1R; 2) Phe-153 and Ile-433 are critical for proper folding and expression of hH1R; and 3) H2R species isoforms distinguish between H1R agonists.	Isoleucine	114-117	histamine receptor H1	Homo sapiens	172-176
12626648-12	2003	These differences may be explained by higher conformational flexibility of gpH1R relative to hH1R; 2) Phe-153 and Ile-433 are critical for proper folding and expression of hH1R; and 3) H2R species isoforms distinguish between H1R agonists.	Isoleucine	114-117	histamine receptor H2	Homo sapiens	185-188
12778490-4	2003	For clone K3-2, from a different patient, the substitution of lysine for glutamine or isoleucine for leucine in the core region resulted in about 30-fold and 10-fold increases in the stimulatory capacity of the peptides, respectively.	Isoleucine	86-96	keratin 32	Homo sapiens	10-14
12626648-8	2003	Phe-153-->Leu-153 or Ile-433-->Val-433 exchange in hH1R (hH1R-->gpH1R) resulted in poor receptor expression, low [3H]mepyramine affinity, and functional inactivity.	Isoleucine	24-27	histamine receptor H1	Homo sapiens	63-67
12626648-9	2003	The Phe-153-->Leu-153/Ile-433-->Val-433 double mutant expressed excellently but only partially changed the pharmacological properties of hH1R.	Isoleucine	25-28	histamine receptor H1	Homo sapiens	143-147
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Isoleucine	32-35	hematopoietic cell signal transducer	Homo sapiens	88-93
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Isoleucine	32-35	killer cell lectin like receptor K1	Homo sapiens	292-297
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Isoleucine	32-35	vav guanine nucleotide exchange factor 1	Homo sapiens	186-190
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Isoleucine	32-35	hematopoietic cell signal transducer	Homo sapiens	298-303
12681984-2	2003	Sequencing of the DKC1 gene revealed an inherited missense mutation in base 1050 (GC), changing methionine to isoleucine.	Isoleucine	110-120	dyskerin pseudouridine synthase 1	Homo sapiens	18-22
12740575-3	2003	Here we show that a crucial Tyr-Ile-Asn-Met amino acid motif in the cytoplasmic tail of DAP10 couples receptor stimulation to the downstream activation of phosphatidylinositol 3-kinase, Vav1, Rho family GTPases and phospholipase C. Unlike that of ITAM-containing receptors, the activation of NKG2D-DAP10 proceeds independently of Syk family protein tyrosine kinases.	Isoleucine	32-35	spleen associated tyrosine kinase	Homo sapiens	330-333
12644454-5	2003	Npl4 NZF binds specifically, but weakly, to free ubiquitin using a conserved 13TF14 dipeptide to interact with the "Ile-44" surface of ubiquitin.	Isoleucine	116-119	NPL4 homolog, ubiquitin recognition factor	Homo sapiens	0-4
12733908-4	2003	The (H)C(CA)NH-COSY scheme is tested on an (15)N,(13)C,(2)H-[Leu, Val, Ile (delta 1 only)]-methyl-protonated maltose binding protein (MBP)/beta-cyclodextrin complex at 5 degrees C (molecular tumbling time 46 +/- 2 ns), facilitating the assignment of (13)C(delta 1) chemical shifts for 18 of the 19 Ile residues for which backbone assignments were previously obtained.	Isoleucine	71-74	myelin basic protein	Homo sapiens	109-132
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Isoleucine	75-78	dihydrofolate reductase	Homo sapiens	276-280
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Isoleucine	75-78	dihydrofolate reductase	Homo sapiens	361-365
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Isoleucine	189-192	dihydrofolate reductase	Homo sapiens	276-280
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Isoleucine	189-192	dihydrofolate reductase	Homo sapiens	361-365
12634355-8	2003	NS3 residue 450 is a threonine in Hel-1a and Hel-1b and is an isoleucine in Hel-2a.	Isoleucine	62-72	KRAS proto-oncogene, GTPase	Homo sapiens	0-3
12738034-9	2003	(3) The side chain of Ile(4.56) (vs Ile(4.56) in 5HT(2B)R and Val(4.56) in 5HT(2C)R) constraints sarpogrelate to adjust its position by translating toward the strongly attractive Asp(3.32).	Isoleucine	22-25	5-hydroxytryptamine receptor 2B	Homo sapiens	49-55
12586825-8	2003	These data identify a second loss-of-function polymorphism within the P2X(7) receptor and show that Ile-568 is critical to the trafficking domain, which we have shown to lie between residues 551 and 581.	Isoleucine	100-103	purinergic receptor P2X 7	Homo sapiens	70-85
12742553-3	2003	The elk pre-PRL cDNA exhibits two polymorphisms at positions 96 and 672, which are silent since they encode for the same amino acids, proline and isoleucine, respectively.	Isoleucine	146-156	prolactin	Equus caballus	12-15
12554754-10	2003	This isoleucine is also conserved in N2 but not in the corresponding S2 domain in SMRT.	Isoleucine	5-15	nuclear receptor corepressor 2	Homo sapiens	82-86
12646697-4	2003	A SNP that results in an amino acid change from Ile to Val in the dual-specific A kinase-anchoring protein 2 (d-AKAP2) gene, showed the strongest correlation with age.	Isoleucine	48-51	A-kinase anchoring protein 10	Homo sapiens	66-108
12646697-4	2003	A SNP that results in an amino acid change from Ile to Val in the dual-specific A kinase-anchoring protein 2 (d-AKAP2) gene, showed the strongest correlation with age.	Isoleucine	48-51	A-kinase anchoring protein 10	Homo sapiens	110-117
12646236-4	2003	In contrast, mMCP-4 hydrolyzed Ang I at two sites, Tyr(4)-Ile(5) and Phe(8)-His(9), with Ang II formation being tentative.	Isoleucine	58-61	mast cell protease 4	Mus musculus	13-19
12444928-5	2003	We could further demonstrate that the critical determinant for binding of APS is the presence of either a leucine or an isoleucine residue in the position +3 to the phosphorylated tyrosine.	Isoleucine	120-130	SH2B adaptor protein 2	Homo sapiens	74-77
12650885-5	2003	RESULTS: SCN5A screening revealed an A-->G substitution at codon 1768, close to the C-terminal end of domain IVS6, which changes an isoleucine to a valine.	Isoleucine	135-145	sodium voltage-gated channel alpha subunit 5	Homo sapiens	9-14
12659185-0	2003	Distinguishing of Ile/Leu amino acid residues in the PP3 protein by (hot) electron capture dissociation in Fourier transform ion cyclotron resonance mass spectrometry.	Isoleucine	18-21	glycosylation dependent cell adhesion molecule 1	Bos taurus	53-56
12482850-3	2003	Proteolysis of pro-Crp4 with MMP-7 activated in vitro bactericidal activity to the level of the mature Crp4 peptide by cleaving pro-Crp4 at Ser(43) downward arrow Ile(44) and Ala(53) downward arrow Leu(54) in the proregion and near the Crp4 peptide NH(2) terminus between Ser(58) downward arrow Leu(59).	Isoleucine	163-166	defensin, alpha, 4	Mus musculus	19-23
12482850-3	2003	Proteolysis of pro-Crp4 with MMP-7 activated in vitro bactericidal activity to the level of the mature Crp4 peptide by cleaving pro-Crp4 at Ser(43) downward arrow Ile(44) and Ala(53) downward arrow Leu(54) in the proregion and near the Crp4 peptide NH(2) terminus between Ser(58) downward arrow Leu(59).	Isoleucine	163-166	matrix metallopeptidase 7	Mus musculus	29-34
12482850-3	2003	Proteolysis of pro-Crp4 with MMP-7 activated in vitro bactericidal activity to the level of the mature Crp4 peptide by cleaving pro-Crp4 at Ser(43) downward arrow Ile(44) and Ala(53) downward arrow Leu(54) in the proregion and near the Crp4 peptide NH(2) terminus between Ser(58) downward arrow Leu(59).	Isoleucine	163-166	defensin, alpha, 4	Mus musculus	103-107
12482850-3	2003	Proteolysis of pro-Crp4 with MMP-7 activated in vitro bactericidal activity to the level of the mature Crp4 peptide by cleaving pro-Crp4 at Ser(43) downward arrow Ile(44) and Ala(53) downward arrow Leu(54) in the proregion and near the Crp4 peptide NH(2) terminus between Ser(58) downward arrow Leu(59).	Isoleucine	163-166	defensin, alpha, 4	Mus musculus	103-107
12482850-3	2003	Proteolysis of pro-Crp4 with MMP-7 activated in vitro bactericidal activity to the level of the mature Crp4 peptide by cleaving pro-Crp4 at Ser(43) downward arrow Ile(44) and Ala(53) downward arrow Leu(54) in the proregion and near the Crp4 peptide NH(2) terminus between Ser(58) downward arrow Leu(59).	Isoleucine	163-166	defensin, alpha, 4	Mus musculus	103-107
12468553-5	2003	Here we have identified two N-TAD residues, Tyr(564) and Ile(565), which, in addition to Pro(563), were critical for pVHL-mediated degradation at normoxia.	Isoleucine	57-60	von Hippel-Lindau tumor suppressor	Mus musculus	117-121
12581880-4	2003	We found that the enhanced homodimerization properties of v-erbA compared to TRalpha1 map to isoleucine at position 339 in conjunction with serine at position 351 and alanine at position 358.	Isoleucine	93-103	thyroid hormone receptor alpha	Homo sapiens	60-64
12446737-9	2003	Mutants Ile(872)-Cys(885) were inaccessible to the extracellular medium and thus localized to the intracellular surface of AE1.	Isoleucine	8-11	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	123-126
12713171-3	2003	The result showed that P97/302 IBDV was most identical to the reported very virulent IBDV strains because it has amino acid substitutions at positions 222, 256, 294, and 299, which encode alanine, isoleucine, isoleucine, and serine, respectively.	Isoleucine	197-207	melanotransferrin	Homo sapiens	23-30
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Isoleucine	223-226	ectodysplasin A	Homo sapiens	48-51
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Isoleucine	27-30	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Isoleucine	64-67	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Isoleucine	64-67	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Isoleucine	64-67	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Isoleucine	64-67	interferon alpha 17	Homo sapiens	20-26
12490315-1	2003	Wild type (wt) p21 Bax was cleaved to generate p18 Bax during apoptotic processes by calpain, which was suggested to recognize a certain motif around amino acids 30-33 Phe-Ile-Gln-Asp (FIQD).	Isoleucine	172-175	BCL2 associated X, apoptosis regulator	Homo sapiens	19-22
12490315-1	2003	Wild type (wt) p21 Bax was cleaved to generate p18 Bax during apoptotic processes by calpain, which was suggested to recognize a certain motif around amino acids 30-33 Phe-Ile-Gln-Asp (FIQD).	Isoleucine	172-175	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
12713171-3	2003	The result showed that P97/302 IBDV was most identical to the reported very virulent IBDV strains because it has amino acid substitutions at positions 222, 256, 294, and 299, which encode alanine, isoleucine, isoleucine, and serine, respectively.	Isoleucine	209-219	melanotransferrin	Homo sapiens	23-30
12502831-6	2003	nsP1 538 lies within the cleavage recognition domain between nsP1 and nsP2, and the presence of the attenuating Ile at nsP1 538 accelerated the processing of S.A.AR86 nonstructural proteins both in vitro and in infected cells.	Isoleucine	112-115	SH2 domain containing 3A	Homo sapiens	0-4
12482550-6	2003	The methionine synthase reductase gene (MTRR) mutation is an A to G substitution, 66A-->G, that converts an isoleucine to a methionine residue.	Isoleucine	111-121	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	4-33
12482550-6	2003	The methionine synthase reductase gene (MTRR) mutation is an A to G substitution, 66A-->G, that converts an isoleucine to a methionine residue.	Isoleucine	111-121	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	40-44
12532156-5	2003	RESULTS: Three common MC3R variants were found: a 17C>A variant, changing Thr6-->Lys in 16%, a 241G>A variant changing Val81-->Ile in 15%, and a -239A>G substitution in the GATA binding site in 21% of the subjects.	Isoleucine	139-142	melanocortin 3 receptor	Homo sapiens	22-26
12502831-6	2003	nsP1 538 lies within the cleavage recognition domain between nsP1 and nsP2, and the presence of the attenuating Ile at nsP1 538 accelerated the processing of S.A.AR86 nonstructural proteins both in vitro and in infected cells.	Isoleucine	112-115	SH2 domain containing 3A	Homo sapiens	61-65
12502831-6	2003	nsP1 538 lies within the cleavage recognition domain between nsP1 and nsP2, and the presence of the attenuating Ile at nsP1 538 accelerated the processing of S.A.AR86 nonstructural proteins both in vitro and in infected cells.	Isoleucine	112-115	SH2 domain containing 3A	Homo sapiens	61-65
12461170-8	2002	Furthermore, the opposing effects of the neu* activating oncogenic point mutation and the Val-655-->Ile single-nucleotide polymorphism shown to be linked to reduced risk of breast cancer are explained in terms of shifts in the equilibrium between the active and inactive states of erbB2 in vivo.	Isoleucine	103-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	284-289
12604719-0	2003	Ile-Leu substitution (I415L) in germline E-cadherin gene (CDH1) in Japanese familial gastric cancer.	Isoleucine	0-3	cadherin 1	Homo sapiens	41-51
12604719-0	2003	Ile-Leu substitution (I415L) in germline E-cadherin gene (CDH1) in Japanese familial gastric cancer.	Isoleucine	0-3	cadherin 1	Homo sapiens	58-62
12501200-2	2002	A glutathione S-transferase (GST)-LBD chimera protein was overexpressed in Escherichia coli, using a vector encoding GST fused with a C-terminal portion of mouse ERalpha (Ser(313)-Ile(599)), via a sequence enclosing a thrombin cleavage site (located 14 amino acids ahead of Ser313).	Isoleucine	180-183	estrogen receptor 1 (alpha)	Mus musculus	162-169
14518824-1	2003	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism affecting isoleucine and ketone bodies in the catabolic process.	Isoleucine	98-108	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38
12376531-10	2002	Taken together, our data show that there is an internalization signal in the COOH terminus of CFTR that consists of Tyr(1424)-X-X-Ile(1427) where both the tyrosine and the isoleucine are essential residues.	Isoleucine	172-182	CF transmembrane conductance regulator	Homo sapiens	94-98
12459476-3	2002	Only the initial cleavage at Gly(35)-Ile(36) was dependent on MT1-MMP activity, as conversion to the active enzyme (Tyr(85) N-terminus) required a functional MMP-13 active site.	Isoleucine	37-40	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	62-69
12486608-1	2002	We recently detected a new single nucleotide polymorphism of FcgammaRIIB gene, which alters an amino acid within the transmembrane domain from Ile to Thr (I232T), and its association with SLE in the Japanese.	Isoleucine	143-146	Fc gamma receptor IIb	Homo sapiens	61-72
12426226-2	2002	A common polymorphism in the human CCR2 gene resulting in a substitution of isoleucine for valine (Val64Ile) has been associated with other disease phenotypes in humans.	Isoleucine	76-86	C-C motif chemokine receptor 2	Homo sapiens	35-39
12542147-6	2002	Analysis of genotypes and shear force values in both populations revealed a difference between paternal CAPN1 alleles in which the allele encoding isoleucine at position 530 and glycine at position 316 associated with decreased meat tenderness (increased shear force values) relative to the allele encoding valine at position 530 and alanine at position 316 (P < 0.05).	Isoleucine	147-157	calpain 1	Bos taurus	104-109
12221096-9	2002	We determined that the inability of XPLN to exchange RhoC is mediated by isoleucine 43 in RhoC, a position occupied by valine in RhoA and RhoB.	Isoleucine	73-83	ras homolog family member C	Homo sapiens	90-94
12457984-6	2002	Isoleucine at position 87 (Ile(87)) of the mature human IL-10 (huIL-10) has been reported as essential for the immuno-stimulatory activity of huIL-10.	Isoleucine	0-10	interleukin 10	Homo sapiens	56-61
12237312-10	2002	The Caenorhabditis elegans ortholog of CHT1 has a valine residue at the corresponding position and a single replacement from valine to isoleucine caused a decrease in the choline uptake rate by 40%, suggesting that this hydrophobic residue is generally critical in the choline transport rate in CHT1.	Isoleucine	135-145	putative endochitinase	Caenorhabditis elegans	39-43
12237312-10	2002	The Caenorhabditis elegans ortholog of CHT1 has a valine residue at the corresponding position and a single replacement from valine to isoleucine caused a decrease in the choline uptake rate by 40%, suggesting that this hydrophobic residue is generally critical in the choline transport rate in CHT1.	Isoleucine	135-145	putative endochitinase	Caenorhabditis elegans	295-299
12362232-3	2002	It converts prothrombin to thrombin by cleaving both the peptide bonds Arg(274)-Thr(275) and Arg(323)-Ile(324), similar to mammalian factor Xa.	Isoleucine	102-105	coagulation factor X	Homo sapiens	133-142
12237254-6	2002	5 The proportion of 5-HT(1A) receptor binding sites detected by [(3)H]-MPPF that displayed high affinity for 8-OH-DPAT was significantly greater when the interacting G protein contained isoleucine rather than glycine at residue(351).	Isoleucine	186-196	5-hydroxytryptamine receptor 1A	Homo sapiens	20-37
12368358-2	2002	Using random mutagenesis of a chimera of maltose-binding protein and LEL residues 113 to 201, we have determined that the E2-binding site on CD81 comprises residues Ile(182), Phe(186), Asn(184), and Leu(162).	Isoleucine	165-168	CD81 molecule	Homo sapiens	141-145
12133832-7	2002	We observed that several hydrophobic residues, Ile(802), Leu(808), Leu(814), Leu(815), and Leu(818), were critical for transactivation and binding to the CH1 domain of CBP in hypoxic cells.	Isoleucine	47-50	CREB binding protein	Mus musculus	168-171
12149252-6	2002	Additional studies revealed that the internal salt bridge (Ile(16)-Asp(194)) of factor Xa(Y225P) is partially destabilized, a process that is reversible upon occupation of the S1 site.	Isoleucine	59-62	coagulation factor X	Homo sapiens	80-89
12207467-1	2002	The cDNAs encoding chicken cystatin and its N-glycosylation-modified mutant (Asn(106)-Ile(108)-->Asn(106)-Thr(108)) were cloned into the pGAPZ alpha C expression vector, using the GAP as promoter and Zeocin as resistant agent, and transformed into Pichia pastoris X-33 expression host.	Isoleucine	86-89	cystatin C	Gallus gallus	27-35
12105206-7	2002	Site-directed mutagenesis of the EGFR L2 domain showed that a cluster of residues, His(394)-Ile(402), was essential for both decorin and EGF binding.	Isoleucine	92-95	epidermal growth factor receptor	Homo sapiens	33-37
12105206-7	2002	Site-directed mutagenesis of the EGFR L2 domain showed that a cluster of residues, His(394)-Ile(402), was essential for both decorin and EGF binding.	Isoleucine	92-95	decorin	Homo sapiens	125-132
12107175-10	2002	Alanine-scanning mutagenesis of residues 105-117 within glutathione S-transferase (GST)-AbetaPP-(18-119) revealed that His(110), Val(112), and Ile(113) are key residues that facilitate AbetaPP binding to fibrillar Abeta.	Isoleucine	143-146	glutathione S-transferase kappa 1	Homo sapiens	56-81
12107175-10	2002	Alanine-scanning mutagenesis of residues 105-117 within glutathione S-transferase (GST)-AbetaPP-(18-119) revealed that His(110), Val(112), and Ile(113) are key residues that facilitate AbetaPP binding to fibrillar Abeta.	Isoleucine	143-146	glutathione S-transferase kappa 1	Homo sapiens	83-86
12163582-6	2002	We conclude that Arg183 within the Pro180-Asn-Ile-Arg-Ser184 sequence of the SIN nsP4 polymerase contributes to the efficient initiation of minus strands or the formation of its replicase and that a host factor(s) participates in this event.	Isoleucine	46-49	serine protease 57	Homo sapiens	81-85
12563566-14	2002	The Ang III- stimulated contraction of collagen by cardiac fibroblasts is completely blocked by the Ang III receptor antagonist, des-Asp(1)-Ile(8)-angiotensin II, and by telmisartan.	Isoleucine	140-143	angiogenin	Rattus norvegicus	4-7
12563566-14	2002	The Ang III- stimulated contraction of collagen by cardiac fibroblasts is completely blocked by the Ang III receptor antagonist, des-Asp(1)-Ile(8)-angiotensin II, and by telmisartan.	Isoleucine	140-143	angiotensinogen	Rattus norvegicus	147-161
12023960-8	2002	Its mutation to either Ile or Val severely reduced the efficacy with which NEK6-phosphorylated peptide substrates, and moreover, mutation of the equivalent Leu residue in S6K1 or SGK1 prevented phosphorylation of their hydrophobic motifs by NEK6 in vitro.	Isoleucine	23-26	NIMA related kinase 6	Homo sapiens	75-79
12324878-4	2002	Sequence analysis revealed a point mutation at position 14568 in the mitochondrial ND6 gene that changes a conserved methionine residue to isoleucine.	Isoleucine	139-149	mitochondrially encoded NADH dehydrogenase 6	Homo sapiens	83-86
12068020-2	2002	The epitope for thrombomodulin binding is shaped as a hot spot in exosite I, centered around the buried ion quartet formed by Arg(67), Lys(70), Glu(77), and Glu(80), and capped by the hydrophobic residues Tyr(76) and Ile(82).	Isoleucine	217-220	thrombomodulin	Homo sapiens	16-30
12023960-8	2002	Its mutation to either Ile or Val severely reduced the efficacy with which NEK6-phosphorylated peptide substrates, and moreover, mutation of the equivalent Leu residue in S6K1 or SGK1 prevented phosphorylation of their hydrophobic motifs by NEK6 in vitro.	Isoleucine	23-26	NIMA related kinase 6	Homo sapiens	241-245
12271374-0	2002	Leber"s hereditary optic neuropathy: clinical and molecular genetic results in a patient with a point mutation at np T11253C (isoleucine to threonine) in the ND4 gene and spontaneous recovery.	Isoleucine	126-136	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	158-161
12271374-8	2002	Sequence analysis of the mtDNA of the patient and his unaffected sister and niece was performed and showed a T to C missense mutation at np 11253 in the ND4 gene, leading to a replacement of an evolutionary highly conserved isoleucine by a threonine residue.	Isoleucine	224-234	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	153-156
12163658-5	2002	The insulin response was closely related to the increase in plasma amino acids, especially leucine, isoleucine, valine, phenylalanine and arginine, regardless of the rate of gastric emptying.	Isoleucine	100-110	insulin	Homo sapiens	4-11
12127072-7	2002	The loss of the terminal isoleucine alone (Delta617-hNET) is sufficient to cause the degradation of hNET, an effect that can be mimicked by nonconservative point mutations at the terminal position.	Isoleucine	25-35	solute carrier family 6 member 2	Homo sapiens	52-56
12127072-7	2002	The loss of the terminal isoleucine alone (Delta617-hNET) is sufficient to cause the degradation of hNET, an effect that can be mimicked by nonconservative point mutations at the terminal position.	Isoleucine	25-35	solute carrier family 6 member 2	Homo sapiens	100-104
12149456-2	2002	Mutations of Thr-315 in the Abl kinase domain to Ile (T315I) were previously described in STI-571-resistant patients and likely cause resistance from steric interference with drug binding.	Isoleucine	49-52	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	28-31
12147342-6	2002	However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A.	Isoleucine	93-96	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	9-15
12175343-5	2002	In addition, the present study shows that the valine to isoleucine (Val1000Ile) polymorphism of A2M is linked with AGD (P=0.03).	Isoleucine	56-66	alpha-2-macroglobulin	Homo sapiens	96-99
12147342-6	2002	However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A.	Isoleucine	93-96	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	69-73
12147342-6	2002	However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A.	Isoleucine	93-96	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	168-172
12137961-6	2002	The ANG II-immunoreactive material was further characterized biochemically by HPLC on a reversed phase C(18) column in an acetonitrile and methanol gradient as Ile(5)-ANG II and ANG II metabolites such as Ile(4)-ANG III, Ile(3)-ANG II(3-8)hexapeptide and Ile(2)-ANG II(4-8)pentapeptide.	Isoleucine	205-208	angiogenin	Homo sapiens	4-7
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	106-109	nuclear receptor subfamily 1, group H, member 4	Mus musculus	71-74
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	106-109	nuclear receptor subfamily 1 group H member 4	Homo sapiens	124-127
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	106-109	nuclear receptor subfamily 1, group H, member 4	Mus musculus	124-127
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	147-150	nuclear receptor subfamily 1, group H, member 4	Mus musculus	71-74
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	147-150	nuclear receptor subfamily 1 group H member 4	Homo sapiens	124-127
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	147-150	nuclear receptor subfamily 1, group H, member 4	Mus musculus	124-127
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Isoleucine	44-47	nuclear receptor subfamily 1, group H, member 4	Mus musculus	82-85
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Isoleucine	44-47	nuclear receptor subfamily 1, group H, member 4	Mus musculus	111-114
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Isoleucine	44-47	nuclear receptor subfamily 1 group H member 4	Homo sapiens	111-114
12004058-0	2002	The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.	Isoleucine	43-53	nuclear receptor subfamily 1 group H member 4	Homo sapiens	67-87
12137961-6	2002	The ANG II-immunoreactive material was further characterized biochemically by HPLC on a reversed phase C(18) column in an acetonitrile and methanol gradient as Ile(5)-ANG II and ANG II metabolites such as Ile(4)-ANG III, Ile(3)-ANG II(3-8)hexapeptide and Ile(2)-ANG II(4-8)pentapeptide.	Isoleucine	160-163	angiogenin	Homo sapiens	4-7
12137961-6	2002	The ANG II-immunoreactive material was further characterized biochemically by HPLC on a reversed phase C(18) column in an acetonitrile and methanol gradient as Ile(5)-ANG II and ANG II metabolites such as Ile(4)-ANG III, Ile(3)-ANG II(3-8)hexapeptide and Ile(2)-ANG II(4-8)pentapeptide.	Isoleucine	160-163	angiotensinogen	Homo sapiens	4-10
12137961-6	2002	The ANG II-immunoreactive material was further characterized biochemically by HPLC on a reversed phase C(18) column in an acetonitrile and methanol gradient as Ile(5)-ANG II and ANG II metabolites such as Ile(4)-ANG III, Ile(3)-ANG II(3-8)hexapeptide and Ile(2)-ANG II(4-8)pentapeptide.	Isoleucine	205-208	angiotensinogen	Homo sapiens	4-10
12137961-6	2002	The ANG II-immunoreactive material was further characterized biochemically by HPLC on a reversed phase C(18) column in an acetonitrile and methanol gradient as Ile(5)-ANG II and ANG II metabolites such as Ile(4)-ANG III, Ile(3)-ANG II(3-8)hexapeptide and Ile(2)-ANG II(4-8)pentapeptide.	Isoleucine	205-208	angiogenin	Homo sapiens	4-7
12137961-6	2002	The ANG II-immunoreactive material was further characterized biochemically by HPLC on a reversed phase C(18) column in an acetonitrile and methanol gradient as Ile(5)-ANG II and ANG II metabolites such as Ile(4)-ANG III, Ile(3)-ANG II(3-8)hexapeptide and Ile(2)-ANG II(4-8)pentapeptide.	Isoleucine	205-208	angiotensinogen	Homo sapiens	4-10
12081649-7	2002	These results suggest that C-terminal residues between Val(276) and Ile(280) play an important role in the expression of AQP4 in the plasma membrane.	Isoleucine	68-71	aquaporin 4	Homo sapiens	121-125
12083782-0	2002	Ile (476), a constituent of di-leucine-based motif of a major lysosomal membrane protein, LGP85/LIMP II, is important for its proper distribution in late endosomes and lysosomes.	Isoleucine	0-3	scavenger receptor class B member 2	Homo sapiens	90-95
12083782-0	2002	Ile (476), a constituent of di-leucine-based motif of a major lysosomal membrane protein, LGP85/LIMP II, is important for its proper distribution in late endosomes and lysosomes.	Isoleucine	0-3	scavenger receptor class B member 2	Homo sapiens	96-103
12083782-9	2002	The fact that isoleucine but not leucine is in the 476th position is especially of importance in the proper distribution of LGP85 in late endosomes and lysosomes.	Isoleucine	14-24	scavenger receptor class B member 2	Homo sapiens	124-129
12081649-8	2002	However, the plasma membrane localization of the AQP4(A(276)AAAA(280)) mutant (alanine substitution of Val(276)-Ile(280) of AQP4) suggests that another signal for membrane targeting exists in the C-terminus of AQP4.	Isoleucine	112-115	aquaporin 4	Homo sapiens	49-53
12081649-8	2002	However, the plasma membrane localization of the AQP4(A(276)AAAA(280)) mutant (alanine substitution of Val(276)-Ile(280) of AQP4) suggests that another signal for membrane targeting exists in the C-terminus of AQP4.	Isoleucine	112-115	aquaporin 4	Homo sapiens	124-128
12081649-8	2002	However, the plasma membrane localization of the AQP4(A(276)AAAA(280)) mutant (alanine substitution of Val(276)-Ile(280) of AQP4) suggests that another signal for membrane targeting exists in the C-terminus of AQP4.	Isoleucine	112-115	aquaporin 4	Homo sapiens	124-128
12039669-3	2002	DNA analysis of the TTR gene revealed a point mutation responsible for substitution of valine for isoleucine at position 107 of the TTR molecule.	Isoleucine	98-108	transthyretin	Homo sapiens	20-23
12089342-10	2002	These data suggest that Ile(133) is a contact residue in SRS-1 of P450arom, emphasize the functional conservation that exists in SRS-1 of a number of steroid-hydroxylating P450 enzymes, and suggest that substrate and inhibitor binding are dependent on different contact points to varying degrees.	Isoleucine	24-27	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	66-74
12089342-10	2002	These data suggest that Ile(133) is a contact residue in SRS-1 of P450arom, emphasize the functional conservation that exists in SRS-1 of a number of steroid-hydroxylating P450 enzymes, and suggest that substrate and inhibitor binding are dependent on different contact points to varying degrees.	Isoleucine	24-27	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	66-70
11980901-8	2002	Within the box2 motif, we determined that the sequence Glu(56)-Ile(57)-Leu(58) of the Mpl cytoplasmic domain is critical for proliferation of the chimeric receptors.	Isoleucine	63-66	myeloproliferative leukemia virus oncogene	Mus musculus	86-89
11937505-3	2002	Recombinant GLY-2 possessed GlcNAc-TV activity when assayed in vitro, and protein truncations demonstrated that the N-terminal boundary of the catalytic domain is Ile-138.	Isoleucine	163-166	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Caenorhabditis elegans	12-17
12127154-4	2002	Next to a frequent T > C single nucleotide polymorphism in exon 8, two novel mutations linked in exon 15 of the OTOF long splice form were identified comprising substitutions at positions 490 (Pro > Gln) and 515 (Ile > Thr), both located in the conserved Ca(2+) binding C2C domain of this peptide.	Isoleucine	213-216	otoferlin	Homo sapiens	112-116
11956215-8	2002	Also, three hydrophobic residues at the rim of the active site (Ile(399), Leu(400), and Leu(552)) were shown to partially penetrate the membrane, thereby promoting membrane binding and activation of cPLA(2).	Isoleucine	64-67	phospholipase A2 group IVA	Homo sapiens	199-206
12039669-3	2002	DNA analysis of the TTR gene revealed a point mutation responsible for substitution of valine for isoleucine at position 107 of the TTR molecule.	Isoleucine	98-108	transthyretin	Homo sapiens	132-135
12023363-7	2002	The codons determining the isotype, Asp(1054), Leu(1101), Ser(1102), Ile(1105) and His(1106), were characteristic of C4B gene, whereas the polymorphic sites in exon and intron 28 were indicative of C4A3a sequence.	Isoleucine	69-72	complement C4B (Chido blood group)	Homo sapiens	117-120
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Isoleucine	90-93	coagulation factor X	Homo sapiens	0-9
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Isoleucine	90-93	coagulation factor X	Homo sapiens	11-14
11877417-12	2002	Ile-4 in Hsp70 and Met-4 in Hsp90 are most important in determining the specific binding of TPR1 and TPR2A, respectively.	Isoleucine	0-3	heat shock protein family A (Hsp70) member 4	Homo sapiens	9-14
11877417-12	2002	Ile-4 in Hsp70 and Met-4 in Hsp90 are most important in determining the specific binding of TPR1 and TPR2A, respectively.	Isoleucine	0-3	heat shock protein 90 alpha family class A member 1	Homo sapiens	28-33
11877417-12	2002	Ile-4 in Hsp70 and Met-4 in Hsp90 are most important in determining the specific binding of TPR1 and TPR2A, respectively.	Isoleucine	0-3	tetratricopeptide repeat domain 1	Homo sapiens	92-96
12051920-3	2002	This mutation results in the conversion of a threonine residue to isoleucine within the antigenic epitope, concomitant with a greater than five log-fold increase in stimulation of a CD4+ tumor-infiltrating lymphocyte line.	Isoleucine	66-76	CD4 molecule	Homo sapiens	182-185
11896689-8	2002	In this helical C-terminus of betaAP, the peptide bond C=O group C-terminal of Ile(31) is located very close to the Met(35) sulfur and could stabilize a Met(35) sulfide radical cation through formation of an (S-O) three-electron bond.	Isoleucine	79-82	amyloid beta precursor protein	Homo sapiens	30-36
11864984-4	2002	Therefore, we mutated six residues located in this region of S6 (Ile(662)-Tyr(667)) to Ala in D540K HERG channels.	Isoleucine	65-68	potassium voltage-gated channel subfamily H member 2	Homo sapiens	100-104
11859090-4	2002	Analyses of additional mutants with deletions at Ile-830, Ala-836, and Ile-840 demonstrated that the Delta 830 mutant exhibited the most significant inhibitory effect on Env steady-state expression.	Isoleucine	49-52	endogenous retrovirus group K member 20	Homo sapiens	170-173
11859090-4	2002	Analyses of additional mutants with deletions at Ile-830, Ala-836, and Ile-840 demonstrated that the Delta 830 mutant exhibited the most significant inhibitory effect on Env steady-state expression.	Isoleucine	71-74	endogenous retrovirus group K member 20	Homo sapiens	170-173
11790775-1	2002	Intracellular application of certain charged methanethiosulfonate (MTS) reagents modified and irreversibly inhibited Kir6.2 channels when cysteine substitutions were introduced at positions Ile-210, Ile-211, or Ser-212 within the putative cytoplasmic region.	Isoleucine	190-193	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	117-123
11790775-1	2002	Intracellular application of certain charged methanethiosulfonate (MTS) reagents modified and irreversibly inhibited Kir6.2 channels when cysteine substitutions were introduced at positions Ile-210, Ile-211, or Ser-212 within the putative cytoplasmic region.	Isoleucine	199-202	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	117-123
11741908-5	2002	Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, residues predicted by the model to be in close proximity to (792)NPKY(795), and Leu(82) and Tyr(144), residues expected to form a hydrophobic pocket near Val(787), are required for the Icap1 alpha-beta(1) integrin interaction.	Isoleucine	48-51	integrin subunit beta 1 binding protein 1	Homo sapiens	74-85
11741908-5	2002	Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, residues predicted by the model to be in close proximity to (792)NPKY(795), and Leu(82) and Tyr(144), residues expected to form a hydrophobic pocket near Val(787), are required for the Icap1 alpha-beta(1) integrin interaction.	Isoleucine	62-65	integrin subunit beta 1 binding protein 1	Homo sapiens	74-85
12054506-4	2002	Motilin fragments 1-14 in which residues 1 (Phe), 4 (Ile), and 7 (Tyr) were replaced by Ala showed the largest reduction in potency.	Isoleucine	53-56	motilin	Homo sapiens	0-7
11942823-6	2002	In contrast, Ile(553) --> Ala exhibits k(cat) and E(act) parameters similar to wild-type soybean lipoxygenase-1 (WT-SLO) for protiated substrate; however, the KIE is markedly temperature dependent.	Isoleucine	13-16	seed linoleate 13S-lipoxygenase-1	Glycine max	100-114
11950882-5	2002	The alignment of evolutionarily diverse syntaxin paralogs shows that an isoleucine residue critical to nSec1-syntaxin complex formation and the characteristic syntaxin glutamine residue are nearly universally conserved, implying a general functional importance for these residues.	Isoleucine	72-82	syntaxin	Saccharomyces cerevisiae S288C	40-48
11950882-5	2002	The alignment of evolutionarily diverse syntaxin paralogs shows that an isoleucine residue critical to nSec1-syntaxin complex formation and the characteristic syntaxin glutamine residue are nearly universally conserved, implying a general functional importance for these residues.	Isoleucine	72-82	syntaxin	Saccharomyces cerevisiae S288C	109-117
11950882-5	2002	The alignment of evolutionarily diverse syntaxin paralogs shows that an isoleucine residue critical to nSec1-syntaxin complex formation and the characteristic syntaxin glutamine residue are nearly universally conserved, implying a general functional importance for these residues.	Isoleucine	72-82	syntaxin	Saccharomyces cerevisiae S288C	109-117
11893600-6	2002	Blood pressure dose-response studies after injection of endotoxin showed a diminished responsiveness to the selective V(1) receptor agonist Phe(2),Ile(3),Orn(8)-vasopressin.	Isoleucine	147-150	arginine vasopressin	Rattus norvegicus	161-172
11933045-9	2002	Furthermore, we found that Ile-166 in the rat 18.5-kDa MBP isomers was replaced by methionine.	Isoleucine	27-30	myelin basic protein	Rattus norvegicus	55-58
11829478-3	2002	Based on the results above, Met(-1) of YaB-G124A was mutated and, as expected, extracellular enzyme production increased with Gln or Ala replacement, but decreased with Ile or Asp substitution.	Isoleucine	169-172	granzyme M	Homo sapiens	28-34
11914035-1	2002	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of ketone body and isoleucine metabolism.	Isoleucine	93-103	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38
12363218-4	2002	Using the X-ray derived conformation of the Ile-Asp-Ser region of VCAM-1, we rationalize the structure-activity relationships of these antagonists using 3D QSAR (COMFA).	Isoleucine	44-47	vascular cell adhesion molecule 1	Homo sapiens	66-72
11866509-0	2002	Chiral mutagenesis of insulin"s hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.	Isoleucine	81-96	insulin	Homo sapiens	22-29
11866509-7	2002	Thus, whereas insulin"s core readily accommodates allo-isoleucine at A2, its activity is exquisitely sensitive to chiral inversion.	Isoleucine	50-65	insulin	Homo sapiens	14-21
11852076-1	2002	Acetohydroxyacid synthase (AHAS; EC 4.1.3.18) contains catalytic and regulatory subunits, the latter being required for sensitivity to feedback regulation by leucine, valine and isoleucine.	Isoleucine	178-188	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	0-25
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Isoleucine	185-188	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	20-28
11719505-5	2002	Replacement of Tyr(63), Ile(66), Asp(69), or Gln(70) by alanine lowered the affinity for LPL and the catalytic activity of the LPL-apoCII complex.	Isoleucine	24-27	lipoprotein lipase	Homo sapiens	89-92
11719505-5	2002	Replacement of Tyr(63), Ile(66), Asp(69), or Gln(70) by alanine lowered the affinity for LPL and the catalytic activity of the LPL-apoCII complex.	Isoleucine	24-27	lipoprotein lipase	Homo sapiens	127-130
11719505-5	2002	Replacement of Tyr(63), Ile(66), Asp(69), or Gln(70) by alanine lowered the affinity for LPL and the catalytic activity of the LPL-apoCII complex.	Isoleucine	24-27	apolipoprotein C2	Homo sapiens	131-137
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Isoleucine	134-137	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	20-28
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Isoleucine	134-137	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	125-133
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Isoleucine	134-137	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	125-133
11842213-3	2002	When the four human p85alpha proteins were expressed in yeast, a 27% decrease occurred in the level of protein expression of p85alpha(Ile/Asp) (P = 0.03) and a 43% decrease in p85alpha(Ile/Asn) (P = 0.08) as compared with p85alpha(Met/Asp).	Isoleucine	134-137	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	125-133
11852076-1	2002	Acetohydroxyacid synthase (AHAS; EC 4.1.3.18) contains catalytic and regulatory subunits, the latter being required for sensitivity to feedback regulation by leucine, valine and isoleucine.	Isoleucine	178-188	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	27-31
11852076-2	2002	The regulatory subunit of Arabidopsis thaliana AHAS possesses a sequence repeat and we have suggested previously that one repeat binds leucine while the second binds valine or isoleucine, with synergy between the two sites.	Isoleucine	176-186	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	47-51
11931086-8	2002	Sequence analysis revealed a point mutation at position 14482 in the mitochondrial ND6 gene that changes a conserved methionine residue to isoleucine.	Isoleucine	139-149	mitochondrially encoded NADH dehydrogenase 6	Homo sapiens	83-86
11898620-2	2002	Allelic frequency of the first mutation, CCR2-64I, causing the substitution of valine with isoleucine in the CCR2 chemokine receptor, was 0.1106 (95% confidence interval, 0.0714-0.1498).	Isoleucine	91-101	C-C motif chemokine receptor 2	Homo sapiens	41-45
11850543-5	2002	All MRT samples had missense mutations in the human KRT 8 gene, i.e., Arg89 --> Cys (5/7); Arg --> Cys251 (3/7); Glu267 --> Lys (6/7); Ser290 --> Ile, Met; (7/7) and Arg301 --> His(4/7), none of which was detected in any control samples.	Isoleucine	158-161	keratin 8	Homo sapiens	52-57
11898620-2	2002	Allelic frequency of the first mutation, CCR2-64I, causing the substitution of valine with isoleucine in the CCR2 chemokine receptor, was 0.1106 (95% confidence interval, 0.0714-0.1498).	Isoleucine	91-101	C-C motif chemokine receptor 2	Homo sapiens	109-113
11677234-10	2002	This change was highly specific for isoleucine, as mutations of Val-349 to alanine, leucine, asparagine, or threonine did not alter or only slightly altered (< or =13%) the S-configuration at C-15.	Isoleucine	36-46	placenta associated 8	Homo sapiens	195-199
11684677-0	2002	Two naturally occurring variants of TAFI (Thr-325 and Ile-325) differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme.	Isoleucine	54-57	carboxypeptidase B2	Homo sapiens	36-40
11684677-3	2002	Screening of nine human cDNA libraries indicated a common variation in TAFI at position 325 (Ile-325 or Thr-325).	Isoleucine	93-96	carboxypeptidase B2	Homo sapiens	71-75
11684677-7	2002	In clot lysis assays with thrombomodulin and the TAFI variants, or with pre-activated TAFI variants, the Ile-325 variants exhibited an antifibrinolytic effect that was 60% greater than the Thr-325 variants.	Isoleucine	105-108	carboxypeptidase B2	Homo sapiens	86-90
11684677-10	2002	The increased antifibrinolytic potential of the Ile-325-containing TAFI variants reflects the fact that these variants have an increased ability to mediate the release of lysine from partially degraded fibrin and suppress plasminogen activation.	Isoleucine	48-51	carboxypeptidase B2	Homo sapiens	67-71
11684677-11	2002	These findings imply that individuals homozygous for the Ile-325 variant of TAFI would likely have a longer lived and more potent TAFIa enzyme than those homozygous for the Thr-325 variant.	Isoleucine	57-60	carboxypeptidase B2	Homo sapiens	76-80
11755207-0	2001	Gamma371 Thr-->Ile substitution in the fibrinogen gammaD domain causes hypofibrinogenaemia.	Isoleucine	15-18	fibrinogen beta chain	Homo sapiens	39-49
11875968-4	2002	The a and b reaction orders were close to 1/2 and 3/2 for Xaa = Ala, Val, Phe, Ser, or Leu, 1/2 and 1 for Gly, Met, or Pro, and 1 and 2 for Ile.	Isoleucine	140-143	WD repeat and HMG-box DNA binding protein 1	Homo sapiens	119-135
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Isoleucine	163-166	beta-lactamase	Klebsiella pneumoniae	73-78
11598113-6	2001	Substitution of Val(2322) for leucine (as in IP(3)R1) or isoleucine (as in RyR2) decreased the binding efficiency and shifted the selectivity to FKBP12.6; substitution of Val(2322) for aspartate completely abolished the FKBP interaction.	Isoleucine	57-67	FKBP prolyl isomerase 1B	Homo sapiens	145-153
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Isoleucine	163-166	TEM beta-lactamase	Klebsiella pneumoniae	36-39
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Isoleucine	163-166	TEM beta-lactamase	Klebsiella pneumoniae	69-72
11731271-3	2001	It was also demonstrated that cathepsin D cleaved bovine aggrecan at five sites within the core protein, between residues Phe(342)-Phe(343) in the interglobular domain, Leu(1462)-Val(1463) between the chondroitin sulfate attachment regions 1 and 2 and Leu(1654)-Val(1655), Phe(1754)-Val(1755) and Leu(1854)-Ile(1855) that are located within the chondroitin sulfate attachment region 2 of the core protein.	Isoleucine	307-310	cathepsin D	Bos taurus	30-41
11895080-6	2001	These results, together with previous reports showed that when the three conserved Val residues were replaced by residues containing a beta-branched side-chain, such as Thr or Ile, the insulin mutants retained higher biological activities than those mutants replaced by other residues.	Isoleucine	176-179	insulin	Homo sapiens	185-192
11829409-3	2001	The rNav1.8 channel, like other vertebrate sodium channel isoforms, contains a conserved isoleucine residue at sequence position 780 that aligns with the conserved methionine at position 918 of Vsscl and other insect sodium channels.	Isoleucine	89-99	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	4-11
11829409-6	2001	Insertion of the mutation corresponding to L1014F (L879F in rNav1.8) reduced the cismethrin sensitivity of channels having either isoleucine or methionine at position 780, whereas channels containing the 1780T/L879F double mutation were insensitive to this insecticide.	Isoleucine	130-140	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	60-67
11708911-6	2001	The selectivity analysis singled out CYP2C8 as the most different of the four CYP2C enzymes with amino acids with distinct properties in positions 114, 205, and 476 (Ser, Phe, and Ile, respectively) compared to the other enzymes.	Isoleucine	180-183	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	37-43
11786202-3	2001	The SarAsp(2)Ile had high affinity to Asp297Lys (IC(50)3.5nM) and partial affinity to the AT2 (IC(50)15nM).	Isoleucine	13-16	angiotensin II receptor type 2	Homo sapiens	90-93
11708911-6	2001	The selectivity analysis singled out CYP2C8 as the most different of the four CYP2C enzymes with amino acids with distinct properties in positions 114, 205, and 476 (Ser, Phe, and Ile, respectively) compared to the other enzymes.	Isoleucine	180-183	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	37-42
11553625-3	2001	We utilized the PTHrP analog, [Bpa(2),Ile(5),Trp(23),Tyr(36)]PTHrP-(1-36)-amide (Bpa(2)-PTHrP-(1-36)), which has valine 2 replaced by p-benzoyl-l-phenylalanine (Bpa); this substitution renders the peptide a photoreactive inverse agonist at hP1R(CAM-HR).	Isoleucine	38-41	collagen type XVII alpha 1 chain	Homo sapiens	81-86
11689007-6	2001	It is possible that the abrogation of CYP1A1 induction in the combined Lys(554) + Ile(570) variant may reduce susceptibility of the host to the carcinogenic effects of polycyclic aromatic hydrocarbons.	Isoleucine	82-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	38-44
11522781-7	2001	In addition, NF-kappaB activity elicited by PGN was significantly attenuated in the presence of synthetic peptide corresponding to the TLR2 region Ser(40)-Ile(64).	Isoleucine	155-158	toll like receptor 2	Homo sapiens	135-139
11668063-4	2001	Systemic administration of the selective adenosine A2A receptor antagonist, 4-(2-[7-amino-2-[2-furyl][3,2,4]triazolol[2,3-a][1,3,5]triazin-5-yl-amino] ethyl)phenol (ZM-241385), significantly (P < 0.05, n = 6) attenuated the SNS-induced vasodilatation.	Isoleucine	118-123	adenosine A2a receptor	Rattus norvegicus	41-63
11817074-8	2001	As with the pheromone-binding protein from Bombyx mori, the residues at positions 61, 64, 71, and 82 in EoriPBP, PajpPBP, and AosaPBP, which are either valine, leucine, isoleucine, or methionine, are likely to be specificity determinants.	Isoleucine	169-179	pheromone-binding protein	Bombyx mori	12-37
11903334-3	2001	A recently identified single nucleotide polymorphism (SNP) in the CPB2 coding region, designated as 1057C > T, results in an amino acid change at TAFI residue 325 (Ile > Thr325).	Isoleucine	167-170	carboxypeptidase B2	Homo sapiens	66-70
11903334-3	2001	A recently identified single nucleotide polymorphism (SNP) in the CPB2 coding region, designated as 1057C > T, results in an amino acid change at TAFI residue 325 (Ile > Thr325).	Isoleucine	167-170	carboxypeptidase B2	Homo sapiens	149-153
11559827-4	2001	Model building indicated that MC54L, which has been shown to bind hIL-18, contains five of the seven amino acids at corresponding positions in its immunoglobulin-like domain, the exceptions being the conservative substitution of isoleucine for a leucine and the nonconservative substitution of valine for a phenylalanine.	Isoleucine	229-239	interleukin 18	Homo sapiens	66-72
11601924-8	2001	The amino acids 109 Phe and 122 Glu in NS3 of CH1392 were substituted by Ile and Lys, respectively, in T1P1.	Isoleucine	73-76	KRAS proto-oncogene, GTPase	Homo sapiens	39-42
11722013-2	2001	The HA1 gene segment of the clinical isolates differed from the recent reference influenza type A (H3N2) vaccine strains in an Ile at residue 186, a Val at residue 194 and a Val at residue 226 for one, two and thirteen isolates of the 1996-1997 and 1996-1999 periods, respectively.	Isoleucine	127-130	Rho GTPase activating protein 45	Homo sapiens	4-7
11564581-14	2001	The risk of CYP1A1 can be supported by the functional difference between presence of valine and isoleucine; valine type has higher catalytic and mutagenic activity towards benzo[a] pyrene than the isoleucine type.	Isoleucine	96-106	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-18
11564581-14	2001	The risk of CYP1A1 can be supported by the functional difference between presence of valine and isoleucine; valine type has higher catalytic and mutagenic activity towards benzo[a] pyrene than the isoleucine type.	Isoleucine	197-207	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-18
11802537-8	2001	After linkage and mutation analysis, the syndrome in this family was associated with a novel KCNQ1 missense mutation, T309I, causing the substitution of a threonine residue at position 309, in the pore region of the KvLQT1 K(+)-channel, with an isoleucine.	Isoleucine	245-255	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	93-98
11802537-8	2001	After linkage and mutation analysis, the syndrome in this family was associated with a novel KCNQ1 missense mutation, T309I, causing the substitution of a threonine residue at position 309, in the pore region of the KvLQT1 K(+)-channel, with an isoleucine.	Isoleucine	245-255	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	216-222
11685249-3	2001	Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP.	Isoleucine	117-120	C-terminal Src kinase	Homo sapiens	64-67
11685249-3	2001	Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP.	Isoleucine	117-120	prolyl endopeptidase	Homo sapiens	189-192
11587526-1	2001	The amino acid permease Bap2p in Saccharomyces cerevisiae mediates a major part of the uptake of leucine, isoleucine, and valine from media containing a preferred nitrogen source.	Isoleucine	106-116	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	24-29
11562450-7	2001	Successive replacement of Ser-251 (D1S4-S5 intracellular loop) and Ile-433 (D1S6 transmembrane segment), with corresponding rH1 residues Ala and Val, reduced, in a stepwise manner, the GTX sensitivity of the chimera and related mutants to that of wild-type rHl.	Isoleucine	67-70	hes family bHLH transcription factor 1	Rattus norvegicus	257-260
11443113-8	2001	Our results indicate that (i) residues Ile-54 and Phe-50 are important in maintaining native ACP conformation, (ii) residue Ala-59 may be directly involved in stabilization of ACP structure by acyl chain binding, and (iii) acyl-ACP synthetase requires native ACP conformation and involves interaction with fatty acid binding pocket residues, whereas myristoyl-ACP thioesterase is insensitive to acyl donor structure.	Isoleucine	39-42	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	93-96
11443113-8	2001	Our results indicate that (i) residues Ile-54 and Phe-50 are important in maintaining native ACP conformation, (ii) residue Ala-59 may be directly involved in stabilization of ACP structure by acyl chain binding, and (iii) acyl-ACP synthetase requires native ACP conformation and involves interaction with fatty acid binding pocket residues, whereas myristoyl-ACP thioesterase is insensitive to acyl donor structure.	Isoleucine	39-42	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	176-179
11443113-8	2001	Our results indicate that (i) residues Ile-54 and Phe-50 are important in maintaining native ACP conformation, (ii) residue Ala-59 may be directly involved in stabilization of ACP structure by acyl chain binding, and (iii) acyl-ACP synthetase requires native ACP conformation and involves interaction with fatty acid binding pocket residues, whereas myristoyl-ACP thioesterase is insensitive to acyl donor structure.	Isoleucine	39-42	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	176-179
11443113-8	2001	Our results indicate that (i) residues Ile-54 and Phe-50 are important in maintaining native ACP conformation, (ii) residue Ala-59 may be directly involved in stabilization of ACP structure by acyl chain binding, and (iii) acyl-ACP synthetase requires native ACP conformation and involves interaction with fatty acid binding pocket residues, whereas myristoyl-ACP thioesterase is insensitive to acyl donor structure.	Isoleucine	39-42	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	176-179
11443113-8	2001	Our results indicate that (i) residues Ile-54 and Phe-50 are important in maintaining native ACP conformation, (ii) residue Ala-59 may be directly involved in stabilization of ACP structure by acyl chain binding, and (iii) acyl-ACP synthetase requires native ACP conformation and involves interaction with fatty acid binding pocket residues, whereas myristoyl-ACP thioesterase is insensitive to acyl donor structure.	Isoleucine	39-42	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	176-179
11590132-7	2001	Two of the SNPs result in Val/Ile and Ala/Thr amino acid substitutions at positions 227 and 357 in the HUT2 open reading frame, respectively.	Isoleucine	30-33	solute carrier family 14 member 2	Homo sapiens	103-107
11442631-9	2001	CONCLUSIONS: Based on these results, we named Yil051c as Ibm1 (Isoleucine Biosynthesis and Mitochondria maintenance1) and concluded that: (i) Ibm1p determines the specificity of isoleucine biosynthesis, probably at the transamination step, (ii) Ibm1p is required for the maintenance of mitochondrial DNA when isoleucine is deficient, and (iii) Isoleucine compensates for the lack of Ibm1p.	Isoleucine	178-188	isoleucine biosynthesis protein MMF1	Saccharomyces cerevisiae S288C	57-61
11525402-3	2001	The alteration, at residue 163 in the yeast polypeptide, substitutes isoleucine for threonine and leads to loss of Cox2p and loss of the ability to carry out cellular respiration.	Isoleucine	69-79	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	115-120
11489133-6	2001	Consistent with a role for Ssy1p in the recognition of amino acids, a mutant form of the protein with a Thr to Ile substitution in the eighth predicted transmembrane domain is competent for the induction of AGP1 by leucine but not by other amino acids.	Isoleucine	111-114	Ssy1p	Saccharomyces cerevisiae S288C	27-32
11489133-6	2001	Consistent with a role for Ssy1p in the recognition of amino acids, a mutant form of the protein with a Thr to Ile substitution in the eighth predicted transmembrane domain is competent for the induction of AGP1 by leucine but not by other amino acids.	Isoleucine	111-114	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	207-211
11274162-3	2001	One protein, AVT1, is required for the vacuolar uptake of large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine, and leucine.	Isoleucine	127-137	Avt1p	Saccharomyces cerevisiae S288C	13-17
11516429-1	2001	beta(2)-adrenoceptors (beta(2)AR) are polymorphic at amino acid 164 (Thr or Ile) of the fourth transmembrane domain.	Isoleucine	76-79	adrenoceptor beta 2	Homo sapiens	0-21
11516429-1	2001	beta(2)-adrenoceptors (beta(2)AR) are polymorphic at amino acid 164 (Thr or Ile) of the fourth transmembrane domain.	Isoleucine	76-79	adrenoceptor beta 2	Homo sapiens	23-32
11514672-0	2001	Arginine-140 and isoleucine-141 determine the 17beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Isoleucine	17-27	sex hormone binding globulin	Homo sapiens	90-117
11514672-0	2001	Arginine-140 and isoleucine-141 determine the 17beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Isoleucine	17-27	sex hormone binding globulin	Homo sapiens	119-122
11514672-0	2001	Arginine-140 and isoleucine-141 determine the 17beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Isoleucine	17-27	sex hormone binding globulin	Homo sapiens	127-131
11514672-1	2001	Arginine-140 and isoleucine-141 were identified as key determinants of 17beta-estradiol (E(2)) binding affinity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Isoleucine	17-27	sex hormone binding globulin	Homo sapiens	119-146
11514672-1	2001	Arginine-140 and isoleucine-141 were identified as key determinants of 17beta-estradiol (E(2)) binding affinity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Isoleucine	17-27	sex hormone binding globulin	Homo sapiens	148-151
11472746-4	2001	A common MTRR polymorphism, i.e. a 66 A-->G substitution specifying an isoleucine to methionine substitution (I22M), was recently identified.	Isoleucine	74-84	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	9-13
11418464-3	2001	An Ala-to-Ile mutation was created in the beta6 position of the mouse beta-major globin gene (beta(6I)) as a step toward the development of a murine model system that could serve as a platform for therapeutic gene correction studies.	Isoleucine	10-13	hemoglobin, beta adult major chain	Mus musculus	70-87
11381131-8	2001	The effect of the opposite substitution, Leu to Ile, makes Toxoplasma gondii apicoplast ACCase resistant to haloxyfop and clodinafop.	Isoleucine	48-51	acetyl-CoA carboxylase 2	Zea mays	88-94
11569502-2	2001	Aspartate kinase (AK) is a key enzyme in the biosynthsis of aspartate family amino acids such as lysine, threonine, isoleucine, and methionine.	Isoleucine	116-126	Aspartate kinase family protein	Arabidopsis thaliana	0-16
11569502-2	2001	Aspartate kinase (AK) is a key enzyme in the biosynthsis of aspartate family amino acids such as lysine, threonine, isoleucine, and methionine.	Isoleucine	116-126	Aspartate kinase family protein	Arabidopsis thaliana	18-20
11442631-9	2001	CONCLUSIONS: Based on these results, we named Yil051c as Ibm1 (Isoleucine Biosynthesis and Mitochondria maintenance1) and concluded that: (i) Ibm1p determines the specificity of isoleucine biosynthesis, probably at the transamination step, (ii) Ibm1p is required for the maintenance of mitochondrial DNA when isoleucine is deficient, and (iii) Isoleucine compensates for the lack of Ibm1p.	Isoleucine	178-188	isoleucine biosynthesis protein MMF1	Saccharomyces cerevisiae S288C	142-147
11278862-5	2001	The work described herein has focused on the Lck SH2 domain, which binds the consensus peptide acetyl-Tyr(P)-Glu-Glu-Ile-amide with a K(D) of 1.3 micrometer.	Isoleucine	117-120	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-48
11434510-6	2001	The GSTP1 gene has a polymorphism at codon 105 resulting in an Ile to Val substitution which consequently alters the enzymatic activity of the protein and this has been suggested as a putative high-risk genotype in various cancers.	Isoleucine	63-66	glutathione S-transferase pi 1	Homo sapiens	4-9
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Isoleucine	111-114	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	16-21
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Isoleucine	111-114	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-21
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Isoleucine	111-114	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	230-235
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Isoleucine	246-249	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	16-21
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Isoleucine	246-249	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-21
11278488-9	2001	FAK was identified as a c-Src (Trp-97 + Ile-98) SH3 domain target in fibroblasts, and co-expression studies in 293T cells showed that full-length c-Src (Trp-97 + Ile-98) could associate in vivo with Phe-397 FAK in an SH2-independent manner.	Isoleucine	40-43	protein tyrosine kinase 2	Homo sapiens	0-3
11278488-9	2001	FAK was identified as a c-Src (Trp-97 + Ile-98) SH3 domain target in fibroblasts, and co-expression studies in 293T cells showed that full-length c-Src (Trp-97 + Ile-98) could associate in vivo with Phe-397 FAK in an SH2-independent manner.	Isoleucine	40-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	24-29
11278488-9	2001	FAK was identified as a c-Src (Trp-97 + Ile-98) SH3 domain target in fibroblasts, and co-expression studies in 293T cells showed that full-length c-Src (Trp-97 + Ile-98) could associate in vivo with Phe-397 FAK in an SH2-independent manner.	Isoleucine	40-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	146-151
11307147-5	2001	Both polymorphic GSTP1 alleles have an A-to-G transition in exon 5, causing an isoleucine-to-valine change.	Isoleucine	79-89	glutathione S-transferase pi 1	Homo sapiens	17-22
11278311-8	2001	An idealized substrate comprising the previously described optimal P4-P1 sequence (Ile-Glu-Pro-Asp) fused to the PI-9 P1"-P4" sequence was efficiently cleaved by granzyme B (k(cat)/K(m) 7.5 x 10(5) s(-1) M(-1)) and was also recognized by caspases.	Isoleucine	83-86	granzyme B	Homo sapiens	162-172
11279156-7	2001	Strands beta1 and beta2 are connected by a small bulge, and the disruption of the first beta-strand were observed with SCM(DR) comprising residues of Ile(38)-Cys(41).	Isoleucine	150-153	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	8-13
11468695-4	2001	Isoleucine (Ile)-valine (Val) and Val-Val genotypes of the CYP1A1 exon 7 polymorphism are associated with an increased risk for lung cancer in certain populations.	Isoleucine	0-10	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	59-65
11278488-9	2001	FAK was identified as a c-Src (Trp-97 + Ile-98) SH3 domain target in fibroblasts, and co-expression studies in 293T cells showed that full-length c-Src (Trp-97 + Ile-98) could associate in vivo with Phe-397 FAK in an SH2-independent manner.	Isoleucine	162-165	protein tyrosine kinase 2	Homo sapiens	0-3
11278488-9	2001	FAK was identified as a c-Src (Trp-97 + Ile-98) SH3 domain target in fibroblasts, and co-expression studies in 293T cells showed that full-length c-Src (Trp-97 + Ile-98) could associate in vivo with Phe-397 FAK in an SH2-independent manner.	Isoleucine	162-165	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	146-151
11336656-8	2001	For alpha1 integrin/protein binding, the conserved Lys-Ile-Gly-Phe-Phe-Lys-Arg motif and, in particular, the two lysine residues, are important.	Isoleucine	55-58	adrenoceptor alpha 1D	Homo sapiens	4-10
11424233-4	2001	RESULTS: There are two alleles in the Kir6.2 gene: EI, glutamic acid at codon 23 and isoleucine at codon 337 and KV, lysine at codon 23 and valine at codon 337.	Isoleucine	85-95	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	38-44
11296260-9	2001	Moreover, two other hydrophobic residues, Val-22 and Ile-27, are crucial for localization of RIalpha at the neuromuscular junction.	Isoleucine	53-56	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	93-100
11274069-11	2001	The decrease in intracellular ROCK-I during the G1 phase was confirmed by arresting the cells in G1 with isoleucine deprivation and thymidine-mimosine treatments.	Isoleucine	105-115	rho-associated protein kinase 1	Oryctolagus cuniculus	30-36
11134050-9	2001	Our results indicate that Ile-335 in MAO A and Tyr-326 in MAO B play a critical role in determining substrate and inhibitor specificities in human MAO A and B.	Isoleucine	26-29	monoamine oxidase A	Homo sapiens	37-42
11259611-2	2001	Mutation of domain IV S6 Ile-1760 of rat brain IIA Na(+) channel or the equivalent (Ile-1575) in the adult rat skeletal muscle isoform (mu 1) creates an artificial access path for QX.	Isoleucine	84-87	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	136-140
11134025-8	2001	Substitution of Ile(214), Asn(216), or Phe(219) with Ala abrogates binding of PKC3 with CKA1; these residues cooperatively configure a docking site that complements an apolar surface of the CKA1 PTB domain.	Isoleucine	16-19	Protein kinase C-like 3	Caenorhabditis elegans	78-82
11134050-9	2001	Our results indicate that Ile-335 in MAO A and Tyr-326 in MAO B play a critical role in determining substrate and inhibitor specificities in human MAO A and B.	Isoleucine	26-29	monoamine oxidase B	Homo sapiens	58-63
11134050-9	2001	Our results indicate that Ile-335 in MAO A and Tyr-326 in MAO B play a critical role in determining substrate and inhibitor specificities in human MAO A and B.	Isoleucine	26-29	monoamine oxidase A	Homo sapiens	147-158
11134025-8	2001	Substitution of Ile(214), Asn(216), or Phe(219) with Ala abrogates binding of PKC3 with CKA1; these residues cooperatively configure a docking site that complements an apolar surface of the CKA1 PTB domain.	Isoleucine	16-19	Choline Kinase A	Caenorhabditis elegans	88-92
11134025-8	2001	Substitution of Ile(214), Asn(216), or Phe(219) with Ala abrogates binding of PKC3 with CKA1; these residues cooperatively configure a docking site that complements an apolar surface of the CKA1 PTB domain.	Isoleucine	16-19	Choline Kinase A	Caenorhabditis elegans	190-194
11031262-5	2001	Recycling of endocytosed GLUT4 was studied by comparing the cellular distributions of antibody/biotin tagged GLUT4 and GLUT4(Ser(5)), a mutant with the Phe(5)-Gln(6)-Gln(7)-Ile(8) inactivated by the substitution of Ser for Phe(5).	Isoleucine	173-176	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	25-30
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	80-83	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	92-97
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	80-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	148-158	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	92-97
11085996-6	2001	A key amino acid that determines the sensitivity to selective COX-2 inhibitors (Ile(523) in COX-1 and Val(523) in COX-2) is present in coral COX as isoleucine.	Isoleucine	148-158	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
11179442-4	2001	Besides Ile 114, Val 367 was also found to be critical for inhibition of CYP2B4 and CYP2B1.	Isoleucine	8-11	cytochrome P450 2B4	Oryctolagus cuniculus	73-79
11179442-4	2001	Besides Ile 114, Val 367 was also found to be critical for inhibition of CYP2B4 and CYP2B1.	Isoleucine	8-11	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	84-90
10880516-8	2001	In this work, the beta-stranded Leu/Ile residues in all LRRs of the human LHR and FSHR were Ala-scanned and characterized.	Isoleucine	36-39	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	74-77
10880516-8	2001	In this work, the beta-stranded Leu/Ile residues in all LRRs of the human LHR and FSHR were Ala-scanned and characterized.	Isoleucine	36-39	follicle stimulating hormone receptor	Homo sapiens	82-86
11078728-1	2001	Serine protease activation is typically controlled by proteolytic cleavage of the scissile bond, resulting in spontaneous formation of the activating Ile(16)-Asp(194) salt bridge.	Isoleucine	150-153	coagulation factor II, thrombin	Homo sapiens	0-15
11285129-4	2001	Here we report the identification of a new IL4RA SNP at the first nucleotide of codon 554 (GTA --> ATA) in exon 11, leading to an amino acid substitution from Val to Ile (V554I).	Isoleucine	169-172	interleukin 4 receptor	Homo sapiens	43-48
11062244-4	2001	Comparisons of binding affinities indicated that the hexapeptide residue at this position interacts with two C5aR residues, Ile-116 (helix III) and Val-286 (helix VII); in a C5aR model these two side chains point toward one another.	Isoleucine	124-127	complement C5a receptor 1	Homo sapiens	109-113
11062244-4	2001	Comparisons of binding affinities indicated that the hexapeptide residue at this position interacts with two C5aR residues, Ile-116 (helix III) and Val-286 (helix VII); in a C5aR model these two side chains point toward one another.	Isoleucine	124-127	complement C5a receptor 1	Homo sapiens	174-178
11062244-7	2001	These results argue that C5aR residues Ile-116 and Val-286 interact with the side chain at position 5 of the hexapeptide ligand to form an activation switch.	Isoleucine	39-42	complement C5a receptor 1	Homo sapiens	25-29
11031262-6	2001	Ablation of the Phe(5)-Gln(6)-Gln(7)-Ile(8) inhibits the recycling of endocytosed GLUT4 to the GLUT4 store compartment and results in its transport to late endosomes/lysosomes where it is rapidly degraded.	Isoleucine	37-40	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	82-87
11031262-6	2001	Ablation of the Phe(5)-Gln(6)-Gln(7)-Ile(8) inhibits the recycling of endocytosed GLUT4 to the GLUT4 store compartment and results in its transport to late endosomes/lysosomes where it is rapidly degraded.	Isoleucine	37-40	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	95-100
11027685-8	2001	These studies reveal specific information about Cyt b membrane topology and structure, namely that gp91phox residues (226)RIVRG(230) and (160)IKNP(163) are closely juxtaposed on extracytoplasmic domains and that predicted helices containing residues Gly(165)-Ile(190) and Ser(200)-Glu(225) are adjacent to each other in the membrane.	Isoleucine	259-262	cytochrome b-245 beta chain	Homo sapiens	99-107
11027685-8	2001	These studies reveal specific information about Cyt b membrane topology and structure, namely that gp91phox residues (226)RIVRG(230) and (160)IKNP(163) are closely juxtaposed on extracytoplasmic domains and that predicted helices containing residues Gly(165)-Ile(190) and Ser(200)-Glu(225) are adjacent to each other in the membrane.	Isoleucine	259-262	mitochondrially encoded cytochrome b	Homo sapiens	48-53
11161836-1	2001	Mitochondrial acetoacetyl-CoA thiolase (T2 enzyme) deficiency (MIM 203750) is an autosomal recessive disorder of isoleucine and ketone-body metabolism.	Isoleucine	113-123	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38
11341914-1	2001	Fungal homoserine dehydrogenase (HSD) is required for the biosynthesis of threonine, isoleucine and methionine from aspartic acid, and is a target for antifungal agents.	Isoleucine	85-95	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	7-31
11342119-2	2001	The cDNA consists of 2701 bp and has a putative open reading frame encoding 131 amino acids which possesses a JAK binding site (Pro(46)-Ile-Pro(48) which is preceded by a cluster of hydrophobic residues) and is highly homologous to the leptin receptor gene-related protein (OB-RGRP).	Isoleucine	136-139	leptin receptor overlapping transcript	Homo sapiens	236-272
11342119-2	2001	The cDNA consists of 2701 bp and has a putative open reading frame encoding 131 amino acids which possesses a JAK binding site (Pro(46)-Ile-Pro(48) which is preceded by a cluster of hydrophobic residues) and is highly homologous to the leptin receptor gene-related protein (OB-RGRP).	Isoleucine	136-139	leptin receptor overlapping transcript	Homo sapiens	274-281
11164310-1	2001	The branched-chain amino acid permease Bap2p is a transport system for leucine, isoleucine, and valine in Saccharomyces cerevisiae, and its synthesis is regulated transcriptionally.	Isoleucine	80-90	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	39-44
11024027-7	2001	Conversely, mutation of Ile(265) in MC3 (the corresponding residue of Tyr(268)) to Tyr displayed a gain of affinity for [d-Tyr(4)]MT-II, but not for Agouti protein, and a loss of affinity for [Nle(4)]Lys-gamma(2)-MSH as compared with wild-type MC3R.	Isoleucine	24-27	melanocortin 3 receptor	Homo sapiens	36-39
11024027-7	2001	Conversely, mutation of Ile(265) in MC3 (the corresponding residue of Tyr(268)) to Tyr displayed a gain of affinity for [d-Tyr(4)]MT-II, but not for Agouti protein, and a loss of affinity for [Nle(4)]Lys-gamma(2)-MSH as compared with wild-type MC3R.	Isoleucine	24-27	melanocortin 3 receptor	Homo sapiens	244-248
11024027-7	2001	Conversely, mutation of Ile(265) in MC3 (the corresponding residue of Tyr(268)) to Tyr displayed a gain of affinity for [d-Tyr(4)]MT-II, but not for Agouti protein, and a loss of affinity for [Nle(4)]Lys-gamma(2)-MSH as compared with wild-type MC3R.	Isoleucine	24-27	metallothionein 2A	Homo sapiens	130-135
11024027-7	2001	Conversely, mutation of Ile(265) in MC3 (the corresponding residue of Tyr(268)) to Tyr displayed a gain of affinity for [d-Tyr(4)]MT-II, but not for Agouti protein, and a loss of affinity for [Nle(4)]Lys-gamma(2)-MSH as compared with wild-type MC3R.	Isoleucine	24-27	proopiomelanocortin	Homo sapiens	213-216
11341914-1	2001	Fungal homoserine dehydrogenase (HSD) is required for the biosynthesis of threonine, isoleucine and methionine from aspartic acid, and is a target for antifungal agents.	Isoleucine	85-95	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	33-36
11341915-1	2001	Homoserine dehydrogenase (HSD), which is required for the synthesis of threonine, isoleucine and methionine in fungi, is a potential target for novel antifungal drugs.	Isoleucine	82-92	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	0-24
11341915-1	2001	Homoserine dehydrogenase (HSD), which is required for the synthesis of threonine, isoleucine and methionine in fungi, is a potential target for novel antifungal drugs.	Isoleucine	82-92	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	26-29
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Isoleucine	146-156	glutathione S-transferase pi 1	Homo sapiens	50-58
11226830-4	2000	Replacement of M107 with isoleucine increased the 5 alpha-dihydrotestosterone K(d) fourfold to a value equal to that of rabbit SBP, which contains isoleucine at the corresponding position; however, the K(d) of 17 beta-estradiol remained unchanged.	Isoleucine	147-157	sex hormone-binding globulin	Oryctolagus cuniculus	127-130
11460477-1	2001	PAI-2 is a serpin that can be crosslinked to fibrin(ogen) via the Gln-Gln-Ile-Gln sequence (residues 83-86).	Isoleucine	74-77	serpin family B member 2	Homo sapiens	0-5
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Isoleucine	290-293	major histocompatibility complex, class II, DP beta 1	Homo sapiens	25-29
10984491-1	2000	The prothrombinase complex, composed of the proteinase, factor Xa, bound to factor Va on membranes, catalyzes thrombin formation by the specific and ordered proteolysis of prothrombin at Arg(323)-Ile(324), followed by cleavage at Arg(274)-Thr(275).	Isoleucine	196-199	coagulation factor II, thrombin	Bos taurus	7-15
11209755-6	2000	The architecture of the substrate binding site of granzyme B appears to be designed to accommodate and cleave hexapeptides such as the sequence Ile-Glu-Thr-Asp-/Ser-Gly present in the activation site of pro-caspase-3, a proven physiological substrate of granzyme B.	Isoleucine	144-147	granzyme B	Homo sapiens	50-60
11209755-6	2000	The architecture of the substrate binding site of granzyme B appears to be designed to accommodate and cleave hexapeptides such as the sequence Ile-Glu-Thr-Asp-/Ser-Gly present in the activation site of pro-caspase-3, a proven physiological substrate of granzyme B.	Isoleucine	144-147	caspase 3	Homo sapiens	203-216
11209755-6	2000	The architecture of the substrate binding site of granzyme B appears to be designed to accommodate and cleave hexapeptides such as the sequence Ile-Glu-Thr-Asp-/Ser-Gly present in the activation site of pro-caspase-3, a proven physiological substrate of granzyme B.	Isoleucine	144-147	granzyme B	Homo sapiens	254-264
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Isoleucine	290-293	major histocompatibility complex, class II, DP beta 1	Homo sapiens	59-63
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Isoleucine	290-293	major histocompatibility complex, class II, DP beta 1	Homo sapiens	59-63
11071881-3	2000	Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine).	Isoleucine	119-129	glutathione S-transferase pi 1	Homo sapiens	19-25
11102558-7	2000	Enzyme studies showed absent activity of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) in the mitochondrial oxidation of 2-methyl branched-chain fatty acids and isoleucine.	Isoleucine	166-176	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	86-90
10995737-5	2000	Lysyl-tRNA synthetase aminoacylates CoA-SH with lysine, leucine, threonine, alanine, valine, and isoleucine.	Isoleucine	97-107	lysyl-tRNA synthetase 1	Homo sapiens	0-21
10995737-3	2000	Here I show that isoleucyl-tRNA synthetase aminoacylates CoA-SH with valine, leucine, threonine, alanine, and serine in addition to isoleucine.	Isoleucine	132-142	isoleucyl-tRNA synthetase 1	Homo sapiens	17-42
10995737-4	2000	Valyl-tRNA synthetase catalyzes aminoacylations of CoA-SH with valine, threonine, alanine, serine, and isoleucine.	Isoleucine	103-113	valyl-tRNA synthetase 1	Homo sapiens	0-21
10995737-7	2000	In contrast, RNA minihelices comprised of the acceptor-TpsiC helix of tRNA(Ile) or tRNA(Val) were aminoacylated by cognate synthetases selectively with isoleucine or valine, respectively.	Isoleucine	152-162	mitochondrially encoded tRNA glycine	Homo sapiens	70-79
11021990-7	2000	Furthermore, we replaced the Ile/Leu residues in the leucine zipper-like domain of Vpr with Ala or Pro and used cells that expressed the mutant protein to demonstrate that Vpr caused apoptosis in a manner that was independent of G(2) arrest.	Isoleucine	29-32	Vpr	Human immunodeficiency virus 1	83-86
11013134-1	2000	Acyl-CoA dehydrogenase (ACAD) defects in isoleucine and valine catabolism have been proposed in clinically diverse patients with an abnormal pattern of metabolites in their urine, but they have not been proved enzymatically or genetically, and it is unknown whether one or two ACADs are involved.	Isoleucine	41-51	acyl-CoA dehydrogenase short chain	Homo sapiens	277-282
11013134-9	2000	In conclusion, we report the first mutation in the SBCAD gene, show that it results in an isolated defect in isoleucine catabolism, and indicate that ACAD-8 is a mitochondrial enzyme that functions in valine catabolism.	Isoleucine	109-119	acyl-CoA dehydrogenase short/branched chain	Homo sapiens	51-56
11013134-9	2000	In conclusion, we report the first mutation in the SBCAD gene, show that it results in an isolated defect in isoleucine catabolism, and indicate that ACAD-8 is a mitochondrial enzyme that functions in valine catabolism.	Isoleucine	109-119	acyl-CoA dehydrogenase family member 8	Homo sapiens	150-156
11128715-3	2000	A base substitution (ATC for TTC) was found in codon 486 of the TSH receptor gene and this resulted in the substitution of an isoleucine for a phenylalanine in the first extracellular loop of the receptor.	Isoleucine	126-136	thyroid stimulating hormone receptor	Homo sapiens	64-76
10906123-6	2000	Synthetic peptides containing Asp and Ile, NKDIL and EPDIM derived from the 2nd and the 4th domains, respectively, almost completely blocked cell adhesion mediated by not only wild type betaig-h3 but also each of the 2nd and the 4th domains.	Isoleucine	38-41	transforming growth factor beta induced	Homo sapiens	186-195
11021990-7	2000	Furthermore, we replaced the Ile/Leu residues in the leucine zipper-like domain of Vpr with Ala or Pro and used cells that expressed the mutant protein to demonstrate that Vpr caused apoptosis in a manner that was independent of G(2) arrest.	Isoleucine	29-32	Vpr	Human immunodeficiency virus 1	172-175
11021990-8	2000	Finally, replacement of Ile/Leu by Pro at positions 60, 67, 74, and 81 within the leucine zipper-like domain of wild-type Vpr and C81 revealed that the Ile/Leu residues at positions 60, 67, and 74 in the leucine zipper-like domain were indispensable for induction of apoptosis induced by Vpr and by C81 and confirmed, in addition, that both processes might be regulated by the same pathway.	Isoleucine	24-27	Vpr	Human immunodeficiency virus 1	122-125
11039907-2	2000	The mutations activating the TSHR gene(s) in the thyroid carcinomas, were located at the codon 623 changing an Ala to a Ser (GCC-->TCC) or in codon 632 changing a Thr to Ala or Ile (ACC-->GCC or ACC-->ATC).	Isoleucine	180-183	thyroid stimulating hormone receptor	Mus musculus	29-33
11015466-7	2000	To a lesser extent, isoleucine also enhanced phosphorylation of 4E-BP1 and S6K1.	Isoleucine	20-30	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	64-70
10862775-0	2000	Unraveling the amino acid sequence crucial for heparin binding to collagen V. We have previously shown that a recombinant 12-kDa fragment of the collagen alpha1(V) chain (Ile(824)-Pro(950)), referred to as HepV, binds to heparin and heparan sulfate (Delacoux, F., Fichard, A., Geourjon, C., Garrone, R., and Ruggiero, F. (1998) J. Biol.	Isoleucine	171-174	collagen type V alpha 1 chain	Homo sapiens	154-163
10880520-7	2000	Molecular modeling of the ORL1 receptor complex with [Bpa(10)]noc suggests that reaction of the Bpa carbonyl group may occur with the side chain of Ile(300) within the experimentally identified photoreactive region.	Isoleucine	148-151	opioid related nociceptin receptor 1	Homo sapiens	26-30
11015466-7	2000	To a lesser extent, isoleucine also enhanced phosphorylation of 4E-BP1 and S6K1.	Isoleucine	20-30	ribosomal protein S6 kinase B1	Rattus norvegicus	75-79
10988120-3	2000	We have, therefore, analyzed polymorphisms of CCR5 (32-bp deletion in CCR5 gene [Delta32]) and of CCR2 (replacement of valine by isoleucine in CCR2 gene [64I]) in 66 Czech patients with sarcoidosis in comparison with a representative sample of Czech normal population.	Isoleucine	129-139	C-C motif chemokine receptor 2	Homo sapiens	143-147
10837470-6	2000	In contrast, blockade of caspase-8 with Ile-Glu-Thr-Asp-fluoromethyl ketone is sufficient to prevent formation of DNA fragments and to inhibit all the above signaling events, with exception of p38 phosphorylation, in both singlet oxygen- and H(2)O(2)-treated cells.	Isoleucine	40-43	caspase 8	Homo sapiens	25-34
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --> Lys, Asn, Thr, Val, or Ile; Pro111 --> Arg, His, Ala, or Leu; Glu112 --> Lys, Gln, or Asp) have been constructed.	Isoleucine	188-191	EcoRII restriction enzyme	Escherichia coli	33-39
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --> Lys, Asn, Thr, Val, or Ile; Pro111 --> Arg, His, Ala, or Leu; Glu112 --> Lys, Gln, or Asp) have been constructed.	Isoleucine	188-191	EcoRII restriction enzyme	Escherichia coli	130-136
11008920-2	2000	A point mutation at codon 462 in exon 7 of CYP1A1 results in a substitution of isoleucine by valine near the heme binding site.	Isoleucine	79-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
10869363-8	2000	The results indicate that regiospecificity is controlled by the presence or absence of a three-residue insert (Ser-114, Gly-115, Ile-116) in CYP4A3 and by the residue at position 119 (CYP4A3 numbering).	Isoleucine	129-132	cytochrome P450, family 4, subfamily a, polypeptide 3	Rattus norvegicus	141-147
10936214-0	2000	Phe(208) and Ile(199) in human monoamine oxidase A and B do not determine substrate and inhibitor specificities as in rat.	Isoleucine	13-16	monoamine oxidase A	Homo sapiens	31-56
10936214-1	2000	It has been reported previously that reciprocally switching Phe(208) and Ile(199) in rat monoamine oxidase (MAO) A and B, respectively, was sufficient to switch their substrate and inhibitor preferences.	Isoleucine	73-76	monoamine oxidase A	Rattus norvegicus	89-120
10964720-1	2000	The recent discovery that mutation Asn21 --> Ile in the human cationic trypsinogen (Tg) is associated with hereditary pancreatitis has brought into focus the functional role of amino acid 21 in mammalian Tgs.	Isoleucine	48-51	serine protease 1	Homo sapiens	65-85
10859319-6	2000	NH(2)-terminal amino acid sequencing revealed that MMP-12 cleaved TFPI at Lys(20)-Leu(21)(close to Kunitz I domain and producing a 35-kDa band), Arg(83)-Ile(84) (between Kunitz I and II domains), and Ser(174)-Thr(175) (between Kunitz II and III domains).	Isoleucine	153-156	matrix metallopeptidase 12	Homo sapiens	51-57
10859319-6	2000	NH(2)-terminal amino acid sequencing revealed that MMP-12 cleaved TFPI at Lys(20)-Leu(21)(close to Kunitz I domain and producing a 35-kDa band), Arg(83)-Ile(84) (between Kunitz I and II domains), and Ser(174)-Thr(175) (between Kunitz II and III domains).	Isoleucine	153-156	tissue factor pathway inhibitor	Homo sapiens	66-70
10950805-3	2000	P. falciparum infections were analyzed by polymerase chain reaction for DHFR mutations, which were dramatically more frequent among prophylaxis-breakthrough infections than at baseline: the prevalence of Asn-108 rose from 13% to 100%, Ile-51 from 4% to 50%, and Arg-59 from 11% to 90%.	Isoleucine	235-238	dihydrofolate reductase	Homo sapiens	72-76
11034565-4	2000	HLA*6812 is identical to HLA-A*68012 except for a single non-synonymous nucleotide substitution leading to an exchange of a threonine to an isoleucine residue at position 142 of the HLA-class I alpha chain.	Isoleucine	140-150	major histocompatibility complex, class I, A	Homo sapiens	25-30
10956190-6	2000	A linear peptide, Ile-Ile-Trp-D-Trp-Leu-Asp, which presumably forms a similar cyclic conformation, was also shown to be a GnRH agonist.	Isoleucine	18-21	gonadotropin releasing hormone 1	Rattus norvegicus	122-126
10801840-5	2000	Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor.	Isoleucine	236-239	vasoactive intestinal peptide	Homo sapiens	54-57
10906151-2	2000	Both angiotensin-(1-7) and D-alanine(7) angiotensin-(1-7) competed with low affinity for (125)I-sarcosine(1), isoleucine(8) angiotensin II binding to AT(1) and AT(2) receptors in rat liver and adrenal medulla membranes, respectively, and competed with low affinity for (125)I-angiotensin IV binding to AT(4) receptors in bovine kidney epithelial cell membranes.	Isoleucine	110-120	angiotensinogen	Rattus norvegicus	124-138
10976799-6	2000	MMP-1 (interstitial collagenase) cleaved the substrates at a single Gly-Ile bond, analogous to the cleavage site in type I collagen.	Isoleucine	72-75	matrix metallopeptidase 1	Homo sapiens	0-5
10976799-6	2000	MMP-1 (interstitial collagenase) cleaved the substrates at a single Gly-Ile bond, analogous to the cleavage site in type I collagen.	Isoleucine	72-75	matrix metallopeptidase 1	Homo sapiens	7-31
10976799-7	2000	MMP-2 (Mr 72 000 type IV collagenase; gelatinase A) was found to cleave the substrates at two sites, a Gly-Ile bond and a Gly-Gln bond.	Isoleucine	107-110	matrix metallopeptidase 2	Homo sapiens	0-5
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Isoleucine	104-107	complement C1s	Homo sapiens	22-25
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Isoleucine	104-107	complement C1r	Homo sapiens	26-29
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Isoleucine	104-107	complement C1r	Homo sapiens	30-33
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Isoleucine	104-107	complement C1s	Homo sapiens	34-37
10915101-3	2000	Of 12 different unmixed allelic combinations, the triple dhfr mutation Asn-108/Arg-59/Ile-51 was observed in all patients responding with early treatment failure.	Isoleucine	86-89	dihydrofolate reductase	Homo sapiens	57-61
10932005-4	2000	RESULTS: One case exhibited an abnormal shift SSCP band in exon 17b of CFTR gene and subsequent DNA sequencing showed C to A transversion at position 3295 that led to a predicted change of Leusine(codon 1055, CTT) to Isoleucine(codon ATT).	Isoleucine	217-227	CF transmembrane conductance regulator	Homo sapiens	71-75
10880057-2	2000	gp130-RAPS is a 50-kDa protein translated from alternatively spliced mRNA and has a truncated form of gp130 with a unique sequence, Asn-Ile-Ala-Ser-Phe (NIASF), in its COOH-terminus.	Isoleucine	136-139	interleukin 6 cytokine family signal transducer	Homo sapiens	0-5
10873678-1	2000	Genetic polyymorphisms that result in three amino acid changes in FcepsilonRI beta chain (Ile(181)-->Leu, Val(183)-->Leu, and Glu(237)-->Gly) have been identified as candidates that associate with allergic disorders such as atopy and asthma.	Isoleucine	90-93	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	66-77
10887336-5	2000	Furthermore, we analyzed CD23 expression and IgE synthesis after IL-4 stimulation of peripheral blood mononuclear cells bearing either Ile(50) or Val(50).	Isoleucine	135-138	interleukin 4	Homo sapiens	65-69
10887116-4	2000	Epitope-mapping studies revealed that scFv VK34 is directed against amino acid residues Arg(484)-Ile(508), a previously identified binding site for factor VIII inhibitors in the A2 domain.	Isoleucine	97-100	immunglobulin heavy chain variable region	Homo sapiens	38-42
10952005-10	2000	Repression of both aspartokinase and aspartate semi-aldehyde dehydrogenase gene transcription in A. mediterranei U32 by L-lysine, L-methionine, L-threonine, and L-isoleucine were found.	Isoleucine	161-173	2-hydroxyacid dehydrogenase	Amycolatopsis mediterranei U32	61-74
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	90-102
10770941-10	2000	However, the requirement of Ile(441) for autoinhibition, which is located at the -3 position from the N-terminal anchoring residue (Trp(444)) to CaM, accounts for the opposite orientation of CaM binding of CaM-KK compared with other CaM kinases.	Isoleucine	28-31	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	206-212
10850388-0	2000	Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis.	Isoleucine	38-41	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	92-98
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Isoleucine	185-195	glutathione S-transferase pi 1	Homo sapiens	96-104
10850388-1	2000	This study evaluated the catalytic activity of three variants (Ile, Leu, and Thr) at codon 359 of CYP2C9 enzymes expressed in a yeast cDNA expression system, and then established single-strand conformation polymorphism (PCR-SSCP) analysis for simultaneous detection as a screening method.	Isoleucine	63-66	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	98-104
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	104-107
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	115-120
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	173-176
10788434-4	2000	The alpha1(I)772-786 and alpha1(II)772-783 THPs were hydrolyzed by MMP-1 at the Gly-Ile and Gly-Leu bonds, respectively, analogous to the bonds cleaved in corresponding native collagens.	Isoleucine	84-87	matrix metallopeptidase 1	Homo sapiens	67-72
10779370-5	2000	Replacement of isoleucine, residue 152 of chimera hb3 (bovine DAT sequence), with valine, the human DAT residue at the identical position, remarkably restored the substrate transport and CFT binding to 76% to 98% of the human DAT values.	Isoleucine	15-25	solute carrier family 6 member 3	Bos taurus	62-65
10826481-2	2000	Additional mutagenesis indicates that important residues in this region for CCR5 binding are Ile-420, Lys-421, Gln-422, Pro-438, and Gly-441.	Isoleucine	93-96	C-C motif chemokine receptor 5	Homo sapiens	76-80
10794685-5	2000	Computational simulations of the complex between this part of the ligand and Phe-208 of MAO-A or Ile-199 of MAO-B, experimentally identified as responsible for substrate selectivity, allowed us to further characterize the nature of these enzyme-inhibitor interactions.	Isoleucine	97-100	monoamine oxidase B	Homo sapiens	108-113
10788459-12	2000	These results indicated that, in contrast to M-PST, mutations at Ala-86, Ile-89, and Ala-146 to the corresponding residues in M-PST are not sufficient for rendering the change of P-PST substrate phenotype to that of M-PST.	Isoleucine	73-76	mercaptopyruvate sulfurtransferase	Homo sapiens	126-131
10788459-12	2000	These results indicated that, in contrast to M-PST, mutations at Ala-86, Ile-89, and Ala-146 to the corresponding residues in M-PST are not sufficient for rendering the change of P-PST substrate phenotype to that of M-PST.	Isoleucine	73-76	mercaptopyruvate sulfurtransferase	Homo sapiens	126-131
10852380-6	2000	This implies that peptides carrying HLA-A*1101 anchor residues (Val, Ile, Phe or Tyr at P2 and Lys at the C-terminus) can bind to HLA-A*3303.	Isoleucine	69-72	major histocompatibility complex, class I, A	Homo sapiens	36-41
10744740-5	2000	The primary mutations in atp1-1 and atp1-2 were identified as Thr(383) --> Ile and Gly(291) --> Asp, respectively.	Isoleucine	78-81	Atp11p	Saccharomyces cerevisiae S288C	25-31
10744740-5	2000	The primary mutations in atp1-1 and atp1-2 were identified as Thr(383) --> Ile and Gly(291) --> Asp, respectively.	Isoleucine	78-81	ATP synthase complex assembly protein ATP12	Saccharomyces cerevisiae S288C	36-42
10938190-4	2000	This transition in the 5"-coding region, resulting in a Thr-Ile substitution, is likely to be the cause of CMT phenotype in our patient, and it represents a new de novo mutation of the Cx32 gene.	Isoleucine	60-63	gap junction protein beta 1	Homo sapiens	185-189
10753900-6	2000	We also found that a peptide containing the segment from Ile/Leu-25 to Lys-53 bound both myosin and heavy meromyosin more strongly and was capable of displacing caldesmon from myosin.	Isoleucine	57-60	myosin heavy chain 14	Homo sapiens	89-95
10753900-6	2000	We also found that a peptide containing the segment from Ile/Leu-25 to Lys-53 bound both myosin and heavy meromyosin more strongly and was capable of displacing caldesmon from myosin.	Isoleucine	57-60	myosin heavy chain 14	Homo sapiens	110-116
10780710-2	2000	The CCR2-64I genetic variant [a G to A substitution resulting in a valine (V) to isoleucine (I) change at position 64] is in strong linkage disequilibrium with a mutation within the CCR5 regulatory region (CCR5-59653T).	Isoleucine	81-91	C-C motif chemokine receptor 2	Homo sapiens	4-8
10780710-2	2000	The CCR2-64I genetic variant [a G to A substitution resulting in a valine (V) to isoleucine (I) change at position 64] is in strong linkage disequilibrium with a mutation within the CCR5 regulatory region (CCR5-59653T).	Isoleucine	81-91	C-C motif chemokine receptor 5	Homo sapiens	182-186
10852380-6	2000	This implies that peptides carrying HLA-A*1101 anchor residues (Val, Ile, Phe or Tyr at P2 and Lys at the C-terminus) can bind to HLA-A*3303.	Isoleucine	69-72	major histocompatibility complex, class I, A	Homo sapiens	130-135
10731151-4	2000	HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes.	Isoleucine	102-112	C-X3-C motif chemokine receptor 1	Homo sapiens	37-43
10737750-2	2000	These libraries were constructed to furnish non-amino acid analogues of the (1) Glu-Glu and (2) Ile residues of the Lck SH2 domain peptide ligand Ac-pTyr-Glu-Glu-Ile-amide.	Isoleucine	96-99	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
10715561-5	2000	The selective V(1) agonist [Phe(2), Ile(3), Orn(8)]-vasopressin caused a significant increase in filopodial length, whereas the selective V(2) agonist [deamino-Cys(1), D-Arg(8)]-vasopressin showed no such effect.	Isoleucine	36-39	arginine vasopressin	Homo sapiens	52-63
10675545-4	2000	Acein-2 was found to be a tripeptide, Leu-Ile-Tyr, which is thought to correspond to f(518-520) of human alpha2-macroglobulin.	Isoleucine	42-45	alpha-2-macroglobulin	Homo sapiens	105-125
10660605-14	2000	Four hydrophobic residues (Cys(23), Val(27), Ile(32), and Cys(44)) in R(CE) are crucial for avid binding with AKAP(CE), whereas side chains from Leu(20), Leu(35), Val(36), Ile(40), and Ile(41) have little impact on complex formation.	Isoleucine	172-175	A-kinase anchoring protein 1	Homo sapiens	110-114
10660605-14	2000	Four hydrophobic residues (Cys(23), Val(27), Ile(32), and Cys(44)) in R(CE) are crucial for avid binding with AKAP(CE), whereas side chains from Leu(20), Leu(35), Val(36), Ile(40), and Ile(41) have little impact on complex formation.	Isoleucine	172-175	A-kinase anchoring protein 1	Homo sapiens	110-114
10655481-1	2000	The third transmembrane domain (TM3) of serotonin transporter (SERT) contains two isoleucine residues previously proposed to be involved in binding and transport of serotonin.	Isoleucine	82-92	tropomyosin 3	Homo sapiens	32-35
10648402-2	2000	The vWf-binding site on GP Ib-IX-V is within the N-terminal 282 residues of GP Ibalpha, which consist of an N-terminal flanking sequence (His-1-Ile-35), 7 leucine-rich repeats (Leu-36-Ala-200), a C-terminal flank (Phe-201-Gly-268), and a sulfated tyrosine sequence (Asp-269-Glu-282).	Isoleucine	144-147	von Willebrand factor	Homo sapiens	4-7
10648402-2	2000	The vWf-binding site on GP Ib-IX-V is within the N-terminal 282 residues of GP Ibalpha, which consist of an N-terminal flanking sequence (His-1-Ile-35), 7 leucine-rich repeats (Leu-36-Ala-200), a C-terminal flank (Phe-201-Gly-268), and a sulfated tyrosine sequence (Asp-269-Glu-282).	Isoleucine	144-147	glycoprotein Ib platelet subunit alpha	Homo sapiens	76-86
10776592-5	2000	One polymorphism was in the coding region, which causes a threonine in the Balb/c mCFI to be replaced by an isoleucine in the 129/SVJ1 mCFI.	Isoleucine	108-118	complement component factor i	Mus musculus	82-86
10776592-5	2000	One polymorphism was in the coding region, which causes a threonine in the Balb/c mCFI to be replaced by an isoleucine in the 129/SVJ1 mCFI.	Isoleucine	108-118	complement component factor i	Mus musculus	135-139
10721503-3	2000	It is found that nimesulide exploits the extra space made available by the replacement at position 523 of an isoleucine residue in COX-1 by a valine in COX-2 and establishes electrostatic interactions with both Arg-106 and Arg-499 (Arg-120 and Arg-513 in PGHS-1 numbering).	Isoleucine	109-119	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	131-136
10751035-7	2000	The aldehyde group of the glyoxylyl residue and the NH-amide of the adjacent isoleucine residue form a piperazinedione derivative of des-gly1-pexiganan.	Isoleucine	77-87	threonine aldolase 1, pseudogene	Homo sapiens	137-141
10644757-8	2000	Paradoxically, [Sar(1),Ile(4), Ile(8)]AngII produced a robust ( approximately 85% of AngII), dose-dependent phosphorylation of the wild type AT(1A) receptor at sites in the carboxyl terminus similar to those phosphorylated by AngII.	Isoleucine	23-26	angiotensinogen	Homo sapiens	38-43
10644757-8	2000	Paradoxically, [Sar(1),Ile(4), Ile(8)]AngII produced a robust ( approximately 85% of AngII), dose-dependent phosphorylation of the wild type AT(1A) receptor at sites in the carboxyl terminus similar to those phosphorylated by AngII.	Isoleucine	23-26	angiotensinogen	Homo sapiens	85-90
10644757-8	2000	Paradoxically, [Sar(1),Ile(4), Ile(8)]AngII produced a robust ( approximately 85% of AngII), dose-dependent phosphorylation of the wild type AT(1A) receptor at sites in the carboxyl terminus similar to those phosphorylated by AngII.	Isoleucine	23-26	angiotensinogen	Homo sapiens	85-90
10644757-8	2000	Paradoxically, [Sar(1),Ile(4), Ile(8)]AngII produced a robust ( approximately 85% of AngII), dose-dependent phosphorylation of the wild type AT(1A) receptor at sites in the carboxyl terminus similar to those phosphorylated by AngII.	Isoleucine	31-34	angiotensinogen	Homo sapiens	38-43
10644757-8	2000	Paradoxically, [Sar(1),Ile(4), Ile(8)]AngII produced a robust ( approximately 85% of AngII), dose-dependent phosphorylation of the wild type AT(1A) receptor at sites in the carboxyl terminus similar to those phosphorylated by AngII.	Isoleucine	31-34	angiotensinogen	Homo sapiens	85-90
10644757-8	2000	Paradoxically, [Sar(1),Ile(4), Ile(8)]AngII produced a robust ( approximately 85% of AngII), dose-dependent phosphorylation of the wild type AT(1A) receptor at sites in the carboxyl terminus similar to those phosphorylated by AngII.	Isoleucine	31-34	angiotensinogen	Homo sapiens	85-90
10648836-3	2000	The hydrophobicity at position 63 is essential for the inactive state of cGK Ialpha, and Ile-78 of cGK Ibeta is also required for the autoinhibitory property.	Isoleucine	89-92	protein kinase cGMP-dependent 1	Homo sapiens	99-108
10601259-2	1999	In contrast to the common view, the transmembrane helices were found to extend roughly to Phe(1129) in alpha2, to Phe(1026) in alpha5, to Ile(757) in beta1, and to His(728) in beta2.	Isoleucine	138-141	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	150-155
10660605-5	2000	Three large aliphatic amino acids (Leu(236), Ile(248), and Leu(252)) in the tethering domain of AKAP(CE) (residues 236-255) are crucial for ligation of R(CE).	Isoleucine	45-48	A-kinase anchoring protein 1	Homo sapiens	96-100
10660605-14	2000	Four hydrophobic residues (Cys(23), Val(27), Ile(32), and Cys(44)) in R(CE) are crucial for avid binding with AKAP(CE), whereas side chains from Leu(20), Leu(35), Val(36), Ile(40), and Ile(41) have little impact on complex formation.	Isoleucine	45-48	A-kinase anchoring protein 1	Homo sapiens	110-114
10601303-3	1999	Based on the x-ray crystal structure of rabbit 15-lipoxygenase, Ile(593) appeared to be important in defining size and shape of the substrate-binding site in 15-lipoxygenases.	Isoleucine	64-67	arachidonate 15-lipoxygenase	Homo sapiens	47-62
10593987-6	1999	Here we present data showing that the furin tail interacts with the medium (micro2) subunit of the AP-2 plasma membrane-specific adaptor complex in vitro and that this interaction primarily depends on recognition of the tyrosine-based sorting signal and to less extent on the leucine-isoleucine motif.	Isoleucine	284-294	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
10655481-1	2000	The third transmembrane domain (TM3) of serotonin transporter (SERT) contains two isoleucine residues previously proposed to be involved in binding and transport of serotonin.	Isoleucine	82-92	solute carrier family 6 member 4	Homo sapiens	40-61
10655481-1	2000	The third transmembrane domain (TM3) of serotonin transporter (SERT) contains two isoleucine residues previously proposed to be involved in binding and transport of serotonin.	Isoleucine	82-92	solute carrier family 6 member 4	Homo sapiens	63-67
10655481-10	2000	The results support the proposal that TM3 of SERT and NET constitute part of the substrate permeation pathway, and that Ile-172 in SERT resides close to the substrate binding site.	Isoleucine	120-123	solute carrier family 6 member 4	Homo sapiens	131-135
10655481-11	2000	They also suggest that Ile-179 in SERT (and Ile-155 in NET) is in a conformationally sensitive part of TM3, which may act as part of an external gate.	Isoleucine	23-26	solute carrier family 6 member 4	Homo sapiens	34-38
10655481-11	2000	They also suggest that Ile-179 in SERT (and Ile-155 in NET) is in a conformationally sensitive part of TM3, which may act as part of an external gate.	Isoleucine	23-26	tropomyosin 3	Homo sapiens	103-106
10655481-11	2000	They also suggest that Ile-179 in SERT (and Ile-155 in NET) is in a conformationally sensitive part of TM3, which may act as part of an external gate.	Isoleucine	44-47	tropomyosin 3	Homo sapiens	103-106
10593987-6	1999	Here we present data showing that the furin tail interacts with the medium (micro2) subunit of the AP-2 plasma membrane-specific adaptor complex in vitro and that this interaction primarily depends on recognition of the tyrosine-based sorting signal and to less extent on the leucine-isoleucine motif.	Isoleucine	284-294	transcription factor AP-2 alpha	Homo sapiens	99-103
10593987-7	1999	We further provide evidence that the three endocytosis signals are of different functional importance for furin internalization and retrieval to the TGN in vivo, with the tyrosine-based motif being the major determinant, followed by the phenylalanine signal, whereas the leucine-isoleucine motif is only a minor component.	Isoleucine	279-289	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
10585457-5	1999	These results are consistent with molecular modeling of the TM V and VI regions of the GnRH receptor, which predicts that Leu(237) is caged by several apolar amino acids (Ile(233), Ile(234), and Val(240) in TM V, and Leu(262), Leu(265), and Val(269) in TM VI) to form a tight hydrophobic cluster.	Isoleucine	171-174	gonadotropin releasing hormone receptor	Homo sapiens	87-100
10626823-1	1999	Two polymorphic variants of manganese superoxide dismutase (MnSOD), with either Ile or Thr at amino acid 58, (Ile58MnSOD or Thr58MnSOD), have been found in the human population.	Isoleucine	80-83	superoxide dismutase 2	Homo sapiens	28-58
10626823-1	1999	Two polymorphic variants of manganese superoxide dismutase (MnSOD), with either Ile or Thr at amino acid 58, (Ile58MnSOD or Thr58MnSOD), have been found in the human population.	Isoleucine	80-83	superoxide dismutase 2	Homo sapiens	60-65
10585457-5	1999	These results are consistent with molecular modeling of the TM V and VI regions of the GnRH receptor, which predicts that Leu(237) is caged by several apolar amino acids (Ile(233), Ile(234), and Val(240) in TM V, and Leu(262), Leu(265), and Val(269) in TM VI) to form a tight hydrophobic cluster.	Isoleucine	181-184	gonadotropin releasing hormone receptor	Homo sapiens	87-100
10574910-8	1999	These results suggest that the 341T --> C (Ile(114) --> Thr) common to the NAT2*5 cluster is sufficient for reduction in NAT2 protein expression, but that mechanisms for slow acetylator phenotype differ for NAT2 alleles that do not contain 341T --> C, such as the NAT2*6 and NAT2*14 clusters.	Isoleucine	46-49	N-acetyltransferase 2	Homo sapiens	81-85
10574910-8	1999	These results suggest that the 341T --> C (Ile(114) --> Thr) common to the NAT2*5 cluster is sufficient for reduction in NAT2 protein expression, but that mechanisms for slow acetylator phenotype differ for NAT2 alleles that do not contain 341T --> C, such as the NAT2*6 and NAT2*14 clusters.	Isoleucine	46-49	N-acetyltransferase 2	Homo sapiens	127-131
10574910-8	1999	These results suggest that the 341T --> C (Ile(114) --> Thr) common to the NAT2*5 cluster is sufficient for reduction in NAT2 protein expression, but that mechanisms for slow acetylator phenotype differ for NAT2 alleles that do not contain 341T --> C, such as the NAT2*6 and NAT2*14 clusters.	Isoleucine	46-49	N-acetyltransferase 2	Homo sapiens	127-131
10574910-8	1999	These results suggest that the 341T --> C (Ile(114) --> Thr) common to the NAT2*5 cluster is sufficient for reduction in NAT2 protein expression, but that mechanisms for slow acetylator phenotype differ for NAT2 alleles that do not contain 341T --> C, such as the NAT2*6 and NAT2*14 clusters.	Isoleucine	46-49	N-acetyltransferase 2	Homo sapiens	127-131
10574910-8	1999	These results suggest that the 341T --> C (Ile(114) --> Thr) common to the NAT2*5 cluster is sufficient for reduction in NAT2 protein expression, but that mechanisms for slow acetylator phenotype differ for NAT2 alleles that do not contain 341T --> C, such as the NAT2*6 and NAT2*14 clusters.	Isoleucine	46-49	N-acetyltransferase 2	Homo sapiens	127-131
10658591-4	1999	The amino acids found to be important for MDL103,392 binding to the NK-1 receptor are Gln-165, His-197, Leu-203, Ile-204, Phe-264, His-265 and Tyr-272.	Isoleucine	113-116	tachykinin receptor 1	Homo sapiens	68-81
10654085-4	1999	Gnp1p, which is closely related to Agp1p, has a somewhat less-broad specificity, transporting Leu, Ser, Thr, Cys, Met, Gln and Asn, while Bap2p and Bap3p, which are also closely related to Agp1p, are able to transport Ile, Leu, Val, Cys, Met, Phe, Tyr and Trp.	Isoleucine	218-221	glutamine permease GNP1	Saccharomyces cerevisiae S288C	0-5
10654085-3	1999	Radiolabelled amino-acid uptake measurements showed that Agp1p is a general permease for most uncharged amino acids (Ala, Gly, Ser, Thr, Cys, Met, Phe, Tyr, Ile, Leu, Val, Gln and Asn).	Isoleucine	157-160	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	57-62
10654085-4	1999	Gnp1p, which is closely related to Agp1p, has a somewhat less-broad specificity, transporting Leu, Ser, Thr, Cys, Met, Gln and Asn, while Bap2p and Bap3p, which are also closely related to Agp1p, are able to transport Ile, Leu, Val, Cys, Met, Phe, Tyr and Trp.	Isoleucine	218-221	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	35-40
10559137-3	1999	The amino acid sequences in interstitial collagen (Gly-Leu/Ile) and laminin-5 (Ala-Leu) that are cleaved by MMP-2 are homologous to a region (Gly(32)-Leu(33)) within human big endothelin-1[1 to 38] (big ET-1).	Isoleucine	59-62	matrix metallopeptidase 2	Homo sapiens	108-113
10724358-5	1999	Analysis of the CYP21 gene revealed that the patient was a compound heterozygote for the Ile-172-->Asn mutation in exon 4 and the 8-bp deletion in exon 3.	Isoleucine	89-92	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	16-21
10559137-3	1999	The amino acid sequences in interstitial collagen (Gly-Leu/Ile) and laminin-5 (Ala-Leu) that are cleaved by MMP-2 are homologous to a region (Gly(32)-Leu(33)) within human big endothelin-1[1 to 38] (big ET-1).	Isoleucine	59-62	endothelin 1	Homo sapiens	176-188
10559137-3	1999	The amino acid sequences in interstitial collagen (Gly-Leu/Ile) and laminin-5 (Ala-Leu) that are cleaved by MMP-2 are homologous to a region (Gly(32)-Leu(33)) within human big endothelin-1[1 to 38] (big ET-1).	Isoleucine	59-62	endothelin 1	Homo sapiens	203-207
10529393-1	1999	Mutations Arg117-->His and Asn21-->Ile of the human cationic trypsinogen have been recently identified in patients affected by hereditary pancreatitis (HP).	Isoleucine	41-44	serine protease 1	Homo sapiens	58-78
10542224-4	1999	Alanine-scanning analysis identified Phe(184), Arg(186), Leu(187), and Ile(190) as important determinants of maximum binding of (125)I-labeled bovine PTH-(1-34) and (125)I-labeled bovine PTH-(3-34) and determinants of responsiveness to the NH(2)-terminal analog, PTH-(1-14) in cAMP stimulation assays.	Isoleucine	71-74	parathyroid hormone	Bos taurus	150-153
10542224-6	1999	At Phe(184) and Leu(187), hydrophobic substitutions (e.g. Ile, Met, or Leu) preserved PTH-(1-34)-mediated cAMP signaling potency, whereas hydrophilic substitutions (e.g. Asp, Glu, Lys, or Arg) weakened this response by 20-fold or more, as compared with the unsubstituted receptor"s response.	Isoleucine	58-61	parathyroid hormone	Bos taurus	86-89
10526198-1	1999	A point mutation at codon 210 of the prion protein gene (PRNP), resulting in the substitution of isoleucine for valine (V210I) has been found in a 54-year-old Moroccan patient affected with Creutzfeldt-Jakob disease (CJD).	Isoleucine	97-107	prion protein	Homo sapiens	57-61
10544105-9	1999	Substitutions of Ile/Leu for Pro at positions 60, 67, 74, and 81 within the leucine zipper-like domain of Vpr or of C81 revealed that Ile60, Leu67, and Ile74 play an important role in the C81-induced suppression of growth, while Ile74 and Ile81 were found to be indispensable for Vpr-induced G(2) arrest.	Isoleucine	17-20	Vpr	Human immunodeficiency virus 1	106-109
10544105-9	1999	Substitutions of Ile/Leu for Pro at positions 60, 67, 74, and 81 within the leucine zipper-like domain of Vpr or of C81 revealed that Ile60, Leu67, and Ile74 play an important role in the C81-induced suppression of growth, while Ile74 and Ile81 were found to be indispensable for Vpr-induced G(2) arrest.	Isoleucine	17-20	Vpr	Human immunodeficiency virus 1	280-283
10514433-8	1999	On the other hand, the highly conserved residues Pro(149), Ile(160), and Leu(164) in the F-box domain of FWD1 were dispensable for binding to Skp1.	Isoleucine	59-62	beta-transducin repeat containing protein	Mus musculus	105-109
10559906-4	1999	Between these two arginines, a conservative change of isoleucine residue 229 in GIRK4 to the corresponding leucine found in IRK1 strengthens GIRK4-PtdIns(4,5)P2 interactions, eliminating the need for extra gating molecules.	Isoleucine	54-64	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	80-85
10521041-12	1999	Results suggest that enhanced delivery of intestinally absorbable isoleucine may stimulate milk lactose synthesis.	Isoleucine	66-76	Weaning weight-maternal milk	Bos taurus	91-95
10551415-3	1999	Analysis using mutants of this peptide at P1, P2 or P9 showed that acidic amino acids at P1 and five hydrophobic residues (Val, Thr, Ile, Leu and Phe) at P2 are anchor residues for the three HLA-A26 molecules while with exception of positively charged amino acids, a broad range of amino acids function as P9 anchor residues.	Isoleucine	133-136	crystallin gamma F, pseudogene	Homo sapiens	42-54
10508448-4	1999	Data from screening of the library shows that plasmin has a strong specificity for Trp at the S2 subsite and prefers to bind hydrophobic and aromatic amino acids such as Ile, Phe, Trp, and Tyr at the S2" subsite.	Isoleucine	170-173	plasminogen	Homo sapiens	46-53
10468556-8	1999	Steric conflict between the oxathiolane ring of 3TCTP and the side chain of beta-branched amino acids (Val, Ile, Thr) at position 184 perturbs inhibitor binding, leading to a reduction in incorporation of the analog.	Isoleucine	108-111	tumor protein, translationally-controlled 1	Homo sapiens	49-53
10446221-2	1999	Several missense IGF2R mutations have been identified in human cancers, including the following amino acid substitutions occurring in the extracytoplasmic domain of the receptor: Cys-1262 --> Ser, Gln-1445 --> His, Gly-1449 --> Val, Gly-1464 --> Glu, and Ile-1572 --> Thr.	Isoleucine	267-270	insulin like growth factor 2 receptor	Homo sapiens	17-22
10446221-4	1999	The Ile-1572 --> Thr mutation eliminated IGF-II binding while not affecting PMP-BSA binding.	Isoleucine	4-7	insulin like growth factor 2	Homo sapiens	44-50
10433688-7	1999	Kinetic analysis of the wild type and the mutant enzymes revealed that both methionine-207 and isoleucine-221 are critical for higher activity of mGSTA1-1 toward (+)-anti-BPDE compared with that of mGSTA2-2.	Isoleucine	95-105	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	146-152
10442767-2	1999	The unprotected peptide precursor 37-43, Thr-Gln-Ile-Asp-Ser-Pro-Leu, was grafted onto functional templates of type naphthalene, biphenyl and benzyl through the chemoselective formation of C- and N-terminal oximes resulting in a mixture of four isomeric forms due to syn-anti isomerism of the oxime bonds.	Isoleucine	49-52	synemin	Homo sapiens	267-270
10521508-11	1999	The ability of coexpressed GRK2 and arrestins to promote internalization of the CXCR4 mutants revealed distinct differences between respective mutants and suggested that the integrity of the dileucine motif (Ile-328 and Leu-329) and serines 324, 325, 338, and 339 are critical for receptor internalization.	Isoleucine	208-211	G protein-coupled receptor kinase 2	Homo sapiens	27-31
10473986-6	1999	Shortening of some polypeptides by the N-terminal amino acid Ile(1) suggestive of aminopeptidase action was also observed.	Isoleucine	61-64	carboxypeptidase Q	Homo sapiens	82-96
10540863-4	1999	Vitamin B12 taken up by the cells is enzymatically converted to coenzyme forms of vitamin B12, methyl- and adenosyl-vitamin B12, which function as coenzymes of methionine synthase (EC 2.1.13), involved in methionine biosynthesis, and methylmalonyl-CoA mutase (EC 5.4.99.2), involved in oxidation of odd-numbered fatty acids and amino acids (valine, isoleucine, and threonine), respectively.	Isoleucine	349-359	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	160-179
10570924-2	1999	This paper reports the identification and possible significance of a novel conserved sequence motif Asp-Trp-(Val/Ile/Leu)-Tyr-Glu-Glu-Glu (DW(V/I/L)YEEE) in the predicted beta propeller domain of the DPP IV-like gene family.	Isoleucine	113-116	dipeptidyl peptidase 4	Homo sapiens	200-206
10515458-1	1999	We showed in a transient coexpression study that a single proline substitution for any of the five conserved leucine or isoleucine residues located in the envelope (Env) transmembrane protein gp41 zipper motif of the human immunodeficiency virus type 1 dominantly interferes with wild-type Env-mediated viral infectivity.	Isoleucine	120-130	endogenous retrovirus group K member 20	Homo sapiens	165-168
10515458-1	1999	We showed in a transient coexpression study that a single proline substitution for any of the five conserved leucine or isoleucine residues located in the envelope (Env) transmembrane protein gp41 zipper motif of the human immunodeficiency virus type 1 dominantly interferes with wild-type Env-mediated viral infectivity.	Isoleucine	120-130	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	290-293
10484490-7	1999	Although the deduced amino acid sequence of mPGT is similar to the rat (91% identity) and human (82% identity) homologues, it has three regions of dissimilarity: amino acids 128-163 and 283-298, and valine 610 and isoleucine 611 (predicted to lie within putative transmembrane span 12).	Isoleucine	214-224	solute carrier organic anion transporter family, member 2a1	Mus musculus	44-48
10438540-8	1999	Our analysis shows that residues Ile(711), Leu(712), Phe(713), Glu(927), and Gly(1413) are essential for Ycf1p expression.	Isoleucine	33-36	ATP-binding cassette glutathione S-conjugate transporter YCF1	Saccharomyces cerevisiae S288C	105-110
10471037-0	1999	The laminin-derived peptide YIGSR (Tyr-Ile-Gly-Ser-Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice.	Isoleucine	39-42	prolactin regulatory element binding	Homo sapiens	71-76
10391916-12	1999	LAT-2 exhibits higher affinity (Km = 30-50 microM) to Tyr, Phe, Trp, Thr, Asn, Ile, Cys, Ser, Leu, Val, and Gln and relatively lower affinity (Km = 180-300 microM) to His, Ala, Met, and Gly.	Isoleucine	79-82	solute carrier family 7 member 8	Rattus norvegicus	0-5
10432069-3	1999	The alleles 51-isoleucine, 59-arginine, and 108-serine of DHFR were significantly associated with clinical resistance, as was allele 581-alanine of DHPS.	Isoleucine	15-25	dihydrofolate reductase	Homo sapiens	58-62
10559906-4	1999	Between these two arginines, a conservative change of isoleucine residue 229 in GIRK4 to the corresponding leucine found in IRK1 strengthens GIRK4-PtdIns(4,5)P2 interactions, eliminating the need for extra gating molecules.	Isoleucine	54-64	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	124-128
10559906-4	1999	Between these two arginines, a conservative change of isoleucine residue 229 in GIRK4 to the corresponding leucine found in IRK1 strengthens GIRK4-PtdIns(4,5)P2 interactions, eliminating the need for extra gating molecules.	Isoleucine	54-64	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	141-146
10360941-10	1999	The hydrophobic side chains of five active-site residues (Met-2, Ile-64, Met-101, Val-106, and Phe-113) and the phenyl moiety of Tyr-95" are responsible for the binding of the phenyl group.	Isoleucine	65-68	methyltransferase 2	Mus musculus	58-63
10381364-2	1999	The carboxyl-terminal end of MAL has the sequence Phe-Ser-Leu-Ile-Arg-Trp-Lys-Ser-Ser (FSLIRWKSS), which includes the LIRW motif necessary for sorting MAL to GEMs, and whose last five amino acids resemble dilysine-based signals involved in endoplasmic reticulum (ER) retention.	Isoleucine	62-65	mal, T cell differentiation protein	Canis lupus familiaris	29-32
10381364-2	1999	The carboxyl-terminal end of MAL has the sequence Phe-Ser-Leu-Ile-Arg-Trp-Lys-Ser-Ser (FSLIRWKSS), which includes the LIRW motif necessary for sorting MAL to GEMs, and whose last five amino acids resemble dilysine-based signals involved in endoplasmic reticulum (ER) retention.	Isoleucine	62-65	mal, T cell differentiation protein	Canis lupus familiaris	151-154
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Isoleucine	47-57	cyclin dependent kinase inhibitor 2A	Mus musculus	61-69
10347200-11	1999	This suggests that the side chain at Ile-455 is critical for myosin motor activity but not for relatively normal enzymatic function, which indicates an apparent uncoupling between enzymatic activity and motile function.	Isoleucine	37-40	myosin heavy chain 14	Homo sapiens	61-67
10351956-3	1999	A transition causing a valine to isoleucine substitution in transmembrane domain I of the CCR2 gene (CCR2-64I) that has a protective effect against the progression of human immunodeficiency virus-1 (HIV-1) disease has been described.	Isoleucine	33-43	C-C motif chemokine receptor 2	Homo sapiens	90-94
10351956-3	1999	A transition causing a valine to isoleucine substitution in transmembrane domain I of the CCR2 gene (CCR2-64I) that has a protective effect against the progression of human immunodeficiency virus-1 (HIV-1) disease has been described.	Isoleucine	33-43	C-C motif chemokine receptor 2	Homo sapiens	101-105
10369752-1	1999	Three polymorphisms of the PKD2 (MIM 173910) gene in patients with autosomal dominant polycystic kidney disease are reported: (1) a substitution from ATT (isoleucine) to GTT (valine) at codon 452; (2) a substitution from CGG (arginine) to CAG (glutamine) at codon 848; and (3) a substitution from G to A in intron 4 of the gene.	Isoleucine	155-165	polycystin 2, transient receptor potential cation channel	Homo sapiens	27-31
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Isoleucine	47-57	cyclin-dependent kinase 6	Mus musculus	96-100
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Isoleucine	47-57	cyclin-dependent kinase 6	Mus musculus	110-114
10365910-8	1999	Functional analysis showed that the proline 18/isoleucine 51 p16INK4a variant was diminished in cdk6 binding, cdk6 inhibition and NIH/3T3 fibroblast growth suppression compared with the histidine 18/valine 51 variant, whereas both of the p19ARF variants suppressed growth with similar potencies.	Isoleucine	47-57	cyclin dependent kinase inhibitor 2A	Mus musculus	238-244
10340378-7	1999	We show that substitution of Ser 955, five residues N-terminal to the Tyr 960 autophosphorylation site (the -5 position), with Ile alters the target specificity of the IR such that it stably associates with Shc in insulin-stimulated cells.	Isoleucine	127-130	SHC adaptor protein 1	Homo sapiens	207-210
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Isoleucine	113-123	glutathione S-transferase pi 1	Homo sapiens	30-37
10331950-4	1999	In addition, we have identified a novel motif, Lys-X-X-Leu/Ile-X-X-Leu/Ile (KIL motif), that is located shortly upstream of a subset of RING-H2 proteins, including RNF6.	Isoleucine	59-62	ring finger protein 6	Rattus norvegicus	164-168
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Isoleucine	113-123	glutathione S-transferase pi 1	Homo sapiens	39-47
10363905-5	1999	The epitope of Glu63-Ser(P)-Ile-Ser(P)-Ser(P)-Ser(P)-Glu-Glu70 was further localised to the phosphoseryl cluster as the peptide Ser(P)-Ser(P)-Ser(P) significantly inhibited binding of the anti-casein antibodies to alpha(s1)-casein(59-79) by 29.5+/-7.4%.	Isoleucine	28-31	proteasome 26S subunit, non-ATPase 1	Homo sapiens	214-222
10385247-7	1999	Mutations of threonine 100 and arginine 102 at the extracellular side of transmembrane II of the guinea-pig 5-HT1D receptor to the corresponding primate residues, isoleucine and histidine, respectively, enhanced its affinity for isochromans to that of the gorilla receptor, with little effects on its affinities for serotonin, sumatriptan and metergoline.	Isoleucine	163-173	5-hydroxytryptamine receptor 1D	Cavia porcellus	108-123
10369401-3	1999	Replacement of valine with isoleucine at this position provides access to a binding site that is larger in COX-2 than in COX-1.	Isoleucine	27-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	107-112
10206953-0	1999	Ile-177 and Ser-180 in the S1 segment are critically important in Kv1.1 channel function.	Isoleucine	0-3	potassium channel, voltage gated shaker related subfamily A, member 1 S homeolog	Xenopus laevis	66-71
10234508-8	1999	The allele PI Mheerlen, a previously described different amino acid substitution in the same position as PI Mwurzburg (Pro369 [CCC] to Leu [CTC]) is shown to cause complete retention of the mutant alpha 1AT in the ER, too, whereas in the recently described mutant allele PI Q0lisbon (Thr68 [ACC] to Ile [ATC]) a significantly reduced alpha 1AT secretion from the cells was observed.	Isoleucine	299-302	serpin family A member 1	Homo sapiens	197-206
10234508-8	1999	The allele PI Mheerlen, a previously described different amino acid substitution in the same position as PI Mwurzburg (Pro369 [CCC] to Leu [CTC]) is shown to cause complete retention of the mutant alpha 1AT in the ER, too, whereas in the recently described mutant allele PI Q0lisbon (Thr68 [ACC] to Ile [ATC]) a significantly reduced alpha 1AT secretion from the cells was observed.	Isoleucine	299-302	serpin family A member 1	Homo sapiens	334-343
10092802-4	1999	Experiments with wild-type DR1 along with previously published results establish that the SDS-stable complexes are formed only when the hydrophobic pocket 1 (P1) is occupied by a bulky aromatic (Trp, Phe, Tyr) or an aliphatic residue (Met, Ile, Val, Leu).	Isoleucine	240-243	down-regulator of transcription 1	Homo sapiens	27-30
10075657-9	1999	The Ile-33 --> Gln point mutant completely inhibited and Arg-38 --> Gln and Ser-36 --> Asp point mutants reduced neurogranin/CaM interactions.	Isoleucine	4-7	neurogranin	Homo sapiens	122-133
10066735-3	1999	Accurate discrimination of the structurally similar amino acids, valine and isoleucine, by isoleucyl-tRNA synthetase (IleRS) results, in part, from a hydrolytic editing reaction, which prevents misactivated valine from being stably joined to tRNAIle.	Isoleucine	76-86	isoleucyl-tRNA synthetase 1	Homo sapiens	91-116
10066735-3	1999	Accurate discrimination of the structurally similar amino acids, valine and isoleucine, by isoleucyl-tRNA synthetase (IleRS) results, in part, from a hydrolytic editing reaction, which prevents misactivated valine from being stably joined to tRNAIle.	Isoleucine	76-86	isoleucyl-tRNA synthetase 1	Homo sapiens	118-123
10052934-6	1999	RBP binds at a 2-fold axis of symmetry in the TTR tetramer, and consequently the recognition site itself has 2-fold symmetry: Four TTR amino acids (Arg-21, Val-20, Leu-82, and Ile-84) are contributed by two monomers.	Isoleucine	176-179	retinol binding protein 4	Homo sapiens	0-3
10049939-5	1999	A C to T mutation identified by cDNA sequencing caused a Thr to Ile conversion in TPI, which could be detected in a tryptic digest of tumor-derived TPI by mass spectrometry.	Isoleucine	64-67	triosephosphate isomerase 1	Homo sapiens	82-85
10102992-7	1999	As the first RNA-binding domain of Sex-lethal (Sxl RBD1) has a characteristic aliphatic residue at one of the two corresponding positions (I128 and F170), Y214 of Sxl RBD2 was replaced by Ile using site-directed mutagenesis.	Isoleucine	188-191	Sex lethal	Drosophila melanogaster	35-45
10049939-5	1999	A C to T mutation identified by cDNA sequencing caused a Thr to Ile conversion in TPI, which could be detected in a tryptic digest of tumor-derived TPI by mass spectrometry.	Isoleucine	64-67	triosephosphate isomerase 1	Homo sapiens	148-151
10344195-6	1999	Alignment of the wild-type ORF with the RT-PCR derived ste1-1 ORF revealed a single amino acid substitution: Thr-114 in the wild-type is changed to Ile in ste1-1.	Isoleucine	148-151	sterol 1	Arabidopsis thaliana	55-59
9971830-2	1999	The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine.	Isoleucine	57-67	C-C motif chemokine receptor 2	Homo sapiens	18-22
9971830-2	1999	The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine.	Isoleucine	57-67	C-C motif chemokine receptor 2	Homo sapiens	49-53
10344195-6	1999	Alignment of the wild-type ORF with the RT-PCR derived ste1-1 ORF revealed a single amino acid substitution: Thr-114 in the wild-type is changed to Ile in ste1-1.	Isoleucine	148-151	sterol 1	Arabidopsis thaliana	155-159
10029083-5	1999	We screened the amino acid sequence of the MCSP molecule for a region of homology to the consensus sequence and found that the amino acid sequence Val-His-Ile-Asn-Ala-His spanning positions 289 and 294 has high homology.	Isoleucine	155-158	chondroitin sulfate proteoglycan 4	Homo sapiens	43-47
10368279-5	1999	RESULTS: The crystal structure of a stable quadruple mutant of PAI-1(Asn150-->His, Lys154-->Thr, Gln319-->Leu, Met354-->Ile) in its active conformation has been solved at a nominal 3 A resolution.	Isoleucine	132-135	serpin family E member 1	Homo sapiens	63-68
10369401-3	1999	Replacement of valine with isoleucine at this position provides access to a binding site that is larger in COX-2 than in COX-1.	Isoleucine	27-37	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	121-126
10369401-7	1999	Docking studies were then undertaken with many different nimesulide conformers, a family of which could establish very favourable interactions with the NSAID binding site of human COX-2 by exploiting the extra space made available by the isoleucine/valine replacement.	Isoleucine	238-248	prostaglandin-endoperoxide synthase 2	Homo sapiens	180-185
10334644-1	1999	OBJECTIVES: The human GSTTP1 gene is polymorphic with an A-->G transition in exon 5 causing a replacement 105 Ile-->Val in the GSTP1 protein.	Isoleucine	113-116	glutathione S-transferase theta 4	Homo sapiens	22-28
10334644-1	1999	OBJECTIVES: The human GSTTP1 gene is polymorphic with an A-->G transition in exon 5 causing a replacement 105 Ile-->Val in the GSTP1 protein.	Isoleucine	113-116	glutathione S-transferase pi 1	Homo sapiens	133-138
10599336-6	1999	Two polymorphisms of the human CYP1A1 gene, a point mutation in the 3" flanking region of the gene (Msp1) and a mutation in exon 7 leading to an isoleucine-valine-exchange in the heme-binding region of the enzyme, have been described and may lead to a higher basal and inducible enzyme activity.	Isoleucine	145-155	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
9973373-3	1999	The substitution of Ile for Val augmented STAT6 activation, proliferation, and transcription activity of the Iepsilon promoter by IL-4, whereas that of Arg for Gln did not change these IL-4 signals.	Isoleucine	20-23	signal transducer and activator of transcription 6	Homo sapiens	42-47
9973373-3	1999	The substitution of Ile for Val augmented STAT6 activation, proliferation, and transcription activity of the Iepsilon promoter by IL-4, whereas that of Arg for Gln did not change these IL-4 signals.	Isoleucine	20-23	interleukin 4	Homo sapiens	130-134
9927626-5	1999	Like whole TSP-1, the Mal II D-Ile derivative inhibited a broad range of angiogenic inducers, was selective for endothelial cells, and required CD36 receptor binding for activity.	Isoleucine	31-34	thrombospondin 1	Mus musculus	11-16
10078329-12	1999	The negative correlation with the dose of CCl4 occurred for taurine and isoleucine (at 48 hours) and taurine, threonine, valine, methionine, isoleucine and leucine (at 96 hours).	Isoleucine	72-82	C-C motif chemokine ligand 4	Rattus norvegicus	42-46
10078329-12	1999	The negative correlation with the dose of CCl4 occurred for taurine and isoleucine (at 48 hours) and taurine, threonine, valine, methionine, isoleucine and leucine (at 96 hours).	Isoleucine	141-151	C-C motif chemokine ligand 4	Rattus norvegicus	42-46
10434950-1	1999	The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21G* basis set.	Isoleucine	53-63	thymidylate synthetase	Homo sapiens	97-117
10434950-1	1999	The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21G* basis set.	Isoleucine	53-63	thymidylate synthetase	Homo sapiens	164-184
10434950-1	1999	The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21G* basis set.	Isoleucine	53-63	tryptase pseudogene 1	Homo sapiens	293-296
10570919-1	1999	We identified a new common amino acid polymorphism of isoleucine/valine at codon 796 in exon 16 of the gene for human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP), a central regulator of lipid synthesis and metabolism in animal cells.	Isoleucine	54-64	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	118-159
10496068-2	1999	The human gene PCMT1 encoding this enzyme has at least four polymorphic sites, one of which results in two major isoforms with either an Ile residue or a Val residue at amino acid position 119.	Isoleucine	137-140	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	15-20
10570919-1	1999	We identified a new common amino acid polymorphism of isoleucine/valine at codon 796 in exon 16 of the gene for human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP), a central regulator of lipid synthesis and metabolism in animal cells.	Isoleucine	54-64	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	161-166
10570919-1	1999	We identified a new common amino acid polymorphism of isoleucine/valine at codon 796 in exon 16 of the gene for human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP), a central regulator of lipid synthesis and metabolism in animal cells.	Isoleucine	54-64	SREBF chaperone	Homo sapiens	197-201
9815240-1	1998	The effect of a valine to isoleucine switch in the CCR2 first transmembrane domain (CCR2 64I) on the clinical course of human immunodeficiency virus type 1 (HIV-1) infection was analyzed in relation to the presence or absence of syncytium-inducing (SI) HIV-1 variants.	Isoleucine	26-36	C-C motif chemokine receptor 2	Homo sapiens	51-55
10195445-5	1999	The insertion of Pro, Gly-Ile or Gly-Pro in this hinge region of L-CA-MA caused retention of both antibacterial and antitumor activity while causing a significant decrease in hemolytic activity.	Isoleucine	26-29	protein tyrosine phosphatase receptor type C	Homo sapiens	65-69
9831690-7	1998	Five polymorphisms have been identified in the transforming growth factor-beta1 gene at positions G-800A, C-509T in the promoter region, Leu10-->Pro, Arg25-->Pro in exon 1 and Thr263-->Ile in exon 5.	Isoleucine	194-197	transforming growth factor beta 1	Homo sapiens	47-79
9815240-1	1998	The effect of a valine to isoleucine switch in the CCR2 first transmembrane domain (CCR2 64I) on the clinical course of human immunodeficiency virus type 1 (HIV-1) infection was analyzed in relation to the presence or absence of syncytium-inducing (SI) HIV-1 variants.	Isoleucine	26-36	C-C motif chemokine receptor 2	Homo sapiens	84-88
9813027-8	1998	The human TS mutants (I108A and F225W), by virtue of their desirable properties, including good catalytic function and resistance to antifolate TS inhibitors, confirm the importance of amino acid residues Ile-108 and Phe-225 in the binding of folate and its analogues.	Isoleucine	205-208	thymidylate synthetase	Homo sapiens	10-12
9894848-4	1998	The results confirmed a previous pool sequencing study of HLA-A*1101 binding self-peptides, which showed that Lys at the C-terminus and Val, Ile, Phe, Tyr, and Thr at P2 are anchor residues for HLA-A*1101.	Isoleucine	141-144	major histocompatibility complex, class I, A	Homo sapiens	58-63
9894848-4	1998	The results confirmed a previous pool sequencing study of HLA-A*1101 binding self-peptides, which showed that Lys at the C-terminus and Val, Ile, Phe, Tyr, and Thr at P2 are anchor residues for HLA-A*1101.	Isoleucine	141-144	major histocompatibility complex, class I, A	Homo sapiens	194-199
9813027-2	1998	Human thymidylate synthase (TS) contains three highly conserved residues Ile-108, Leu-221, and Phe-225 that have been suggested to be important for cofactor and antifolate binding.	Isoleucine	73-76	thymidylate synthetase	Homo sapiens	6-26
9813027-2	1998	Human thymidylate synthase (TS) contains three highly conserved residues Ile-108, Leu-221, and Phe-225 that have been suggested to be important for cofactor and antifolate binding.	Isoleucine	73-76	thymidylate synthetase	Homo sapiens	28-30
9826525-2	1998	The amino acid sequence deduced from the cDNA showed that ESP-1 comprises a signal peptide of 18 amino acids, a propeptide of 23 amino acids, an active form sequence of 273 amino acids starting from an Ile-Val-Gly-Gly-Glu motif, the catalytic triad of serine proteases that has been characterized as the essential amino acid residues for the proteolytic activity, and a hydrophobic amino acid stretch in the carboxyl terminus, suggesting this enzyme is a novel membrane-type serine protease.	Isoleucine	202-205	serine protease 21	Homo sapiens	58-63
9814481-1	1998	The objective of the present study was to investigate whether the frequent amino acid polymorphisms, Ile/Leu27 and Ser/Asn487, of the hepatocyte nuclear factor-1alpha gene were associated with alterations in glucose-induced serum C-peptide and serum insulin responses among glucose-tolerant first-degree relatives of type 2 diabetic patients.	Isoleucine	101-104	HNF1 homeobox A	Homo sapiens	134-166
9774438-5	1998	The transamination product of leucine, alpha-ketoisocaproic acid, also stimulates PHAS-I phosphorylation although the transamination products of isoleucine and valine are ineffective.	Isoleucine	145-155	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	82-88
9756943-5	1998	Yap3p, a well characterized GPI-anchored plasma membrane aspartic protease, was localized in the cell wall when the omega-minus region was mutated to sequences containing Val or Ile at the omega-4 or -5 site and Val or Tyr at the omega-2 site.	Isoleucine	178-181	Yap3p	Saccharomyces cerevisiae S288C	0-5
9729461-4	1998	Here we report the effect on the reduction of two ketone and two aldehyde substrates by pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase in which tyrosine-194 has been mutated to phenylalanine and cysteine, and lysine-198 has been mutated to isoleucine and arginine.	Isoleucine	245-255	carbonyl reductase [NADPH] 1	Sus scrofa	92-139
9679769-0	1998	Laminin-alpha1-chain sequence Leu-Gln-Val-Gln-Leu-Ser-Ile-Arg (LQVQLSIR) enhances murine melanoma cell metastases.	Isoleucine	54-57	laminin, alpha 1	Mus musculus	0-14
9743615-3	1998	An analog peptide L142I with a substitution of Ile for Leu at the nonanchor N-terminal residue induced more IFN-gamma secretion than p142-149 from specific CD8(+) T cells.	Isoleucine	47-50	interferon gamma	Bos taurus	108-117
9796859-2	1998	Of special interest is the finding that amino acid substitutions of the Tat(1-9) peptide (MDPVDPNIE) in position 5 with S-isoleucine and in position 6 with S-leucine led to peptides with strongly reduced inhibitory activity suggesting differences in the solution conformation of the three analogues.	Isoleucine	120-132	solute carrier family 26 member 8	Homo sapiens	72-79
9655916-8	1998	When these residues were changed to Leu and Ile respectively, TFIIIA-dependent DNase I protection was observed along the entire 5S gene ICR.	Isoleucine	44-47	general transcription factor 3A L homeolog	Xenopus laevis	62-68
9777415-9	1998	We stabilized the zymogen form of human C1r by mutating the Arg(463)-Ile(464) bond.	Isoleucine	69-72	complement C1r	Homo sapiens	40-43
9655916-8	1998	When these residues were changed to Leu and Ile respectively, TFIIIA-dependent DNase I protection was observed along the entire 5S gene ICR.	Isoleucine	44-47	DNase I	Xenopus laevis	79-86
9688851-0	1998	Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy.	Isoleucine	45-48	troponin T1, slow skeletal type	Homo sapiens	66-76
9620866-9	1998	When Ile-70 of the protein encoded by AMD2 was converted into Met, both the catalytic and processing activities recovered markedly, indicating that Met-70 adjacent to the proenzyme-processing site is important for both activities.	Isoleucine	5-8	S-adenosylmethionine decarboxylase 2	Mus musculus	38-42
9622134-7	1998	Analysis of the coding region of the leptin gene (exons 2 and 3) by single-strand conformational polymorphism revealed a rare Ile-Val polymorphism at amino acid 45 but revealed no other alterations.	Isoleucine	126-129	leptin	Homo sapiens	37-43
9690921-8	1998	Analysis of two previously reported polymorphisms also located in the amino-terminal domain of apo B (Thr71-->Ile and Val591-->Ala) revealed elevating effects on serum apo B concentrations in hypertriglyceridemic individuals.	Isoleucine	113-116	apolipoprotein B	Homo sapiens	95-100
9690921-8	1998	Analysis of two previously reported polymorphisms also located in the amino-terminal domain of apo B (Thr71-->Ile and Val591-->Ala) revealed elevating effects on serum apo B concentrations in hypertriglyceridemic individuals.	Isoleucine	113-116	apolipoprotein B	Homo sapiens	174-179
9580670-6	1998	Secondly, sequence analysis, together with allele-specific PCR and the amplification-created restriction site (ACRS) technique, revealed a dinucleotide TC-->AG mutation, which changed isoleucine to lysine in the predicted first transmembrane domain of the EDNRB protein.	Isoleucine	187-197	endothelin receptor type B	Equus caballus	259-264
9700506-7	1998	HLA-G binds nonamer peptides with leucine or isoleucine at position 2, proline at position 3 and leucine at position 9.	Isoleucine	45-55	major histocompatibility complex, class I, G	Homo sapiens	0-5
9623760-1	1998	A novel tumor necrosis factor-alpha mutant (mutant M3), in which Ser and Tyr at positions 52 and 56 were substituted by Ile and Phe, respectively, along with deletion of 7 N-terminal amino acids, was prepared and its biological activities were investigated.	Isoleucine	120-123	tumor necrosis factor	Homo sapiens	8-35
9582298-3	1998	This has allowed the identification of the sequence Leu-Ile-Arg-Trp (LIRW) as necessary for the access of MAL to GEMs.	Isoleucine	56-59	mal, T cell differentiation protein	Homo sapiens	106-109
9576856-4	1998	Two human class Pi (P) enzymes (GST P1-1 with Ile or Val at position 105) displayed no activity towards the phospholipid hydroperoxide.	Isoleucine	46-49	glutathione S-transferase pi 1	Homo sapiens	32-38
9560305-9	1998	In Cyp2d-9, the corresponding position is occupied by an isoleucine residue, which imposes fewer steric restraints on the size of substrate that can access the active site.	Isoleucine	57-67	cytochrome P450, family 2, subfamily d, polypeptide 9	Mus musculus	3-10
9560305-10	1998	To investigate whether the amino acid residue at this position does indeed influence the catalytic selectivity of these enzymes, site-directed mutagenesis was used to change Phe-483 in CYP2D6 to isoleucine and also to tryptophan.	Isoleucine	195-205	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	185-191
9560319-4	1998	Mutation of this residue to Leu, Ile, Lys, Glu or Phe in the human GnRH receptor did not result in constitutive activity and instead led to complete uncoupling of the receptor (failure to support GnRH-stimulated inositol phosphate production).	Isoleucine	33-36	gonadotropin releasing hormone receptor	Homo sapiens	67-80
9560319-4	1998	Mutation of this residue to Leu, Ile, Lys, Glu or Phe in the human GnRH receptor did not result in constitutive activity and instead led to complete uncoupling of the receptor (failure to support GnRH-stimulated inositol phosphate production).	Isoleucine	33-36	gonadotropin releasing hormone 1	Homo sapiens	67-71
9548745-1	1998	Isoleucyl-tRNA synthetase (IleRS) catalyzes transfer of isoleucine from the enzyme-bound Ile-AMP and Ile-tRNA to the thiol group of coenzyme A, forming a thioester, Ile-S-CoA.	Isoleucine	56-66	isoleucyl-tRNA synthetase 1	Homo sapiens	0-25
9635276-7	1998	In addition, these isoforms all contain the four residue PP1c-binding motif (Arg/Lys-Val/Ile-Xaa-Phe).	Isoleucine	89-92	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	57-61
9548745-1	1998	Isoleucyl-tRNA synthetase (IleRS) catalyzes transfer of isoleucine from the enzyme-bound Ile-AMP and Ile-tRNA to the thiol group of coenzyme A, forming a thioester, Ile-S-CoA.	Isoleucine	56-66	isoleucyl-tRNA synthetase 1	Homo sapiens	27-32
9666356-9	1998	Significantly higher concentrations of plasma tyrosine, phenylalanine, valine, leucine, isoleucine, and citrulline (P < 0.05) were found in Ts65Dn mice.	Isoleucine	88-98	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	143-149
9616041-4	1998	Although each mutation caused reduced thermal stability, an amino acid substitution Thr-5-->Ile (T5I) exhibited marked thermal instability, suggesting that the amino-terminal of GPI is important for enzymatic stability.	Isoleucine	95-98	glucose-6-phosphate isomerase	Homo sapiens	181-184
9588171-5	1998	The conversion may be accomplished by another protease(s) with a trypsin-like cleavage specificity, since it is unlikely that the mature TESP1 and TESP2 are capable of splitting the Lys-Ile bond between the light and heavy chains.	Isoleucine	186-189	protease, serine 39	Mus musculus	137-142
9588171-5	1998	The conversion may be accomplished by another protease(s) with a trypsin-like cleavage specificity, since it is unlikely that the mature TESP1 and TESP2 are capable of splitting the Lys-Ile bond between the light and heavy chains.	Isoleucine	186-189	protease, serine 40	Mus musculus	147-152
9546050-1	1998	The Ile-Pro sequence of CA074, potent covalent-type inhibitor, is necessary to exhibit the specificity for cathepsin B, but not for papain.	Isoleucine	4-7	cathepsin B	Homo sapiens	107-118
9521670-4	1998	Analysis of the deduced amino acid sequences revealed that a single base mutation resulted in the encoding of a Thr in the mutant HPRT, instead of an Ile found in the wild-type enzyme, at a position analogous to position 192 (Leu-192) of the human HPRT.	Isoleucine	150-153	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	130-134
9525277-1	1998	Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates.	Isoleucine	157-167	glutathione S-transferase pi 1	Homo sapiens	169-176
9525277-8	1998	With the syn-diol epoxides, such a correlation was observed with alanine, valine and isoleucine, whereas tryptophan was associated with increased kcat/Km values.	Isoleucine	85-95	synemin	Homo sapiens	9-12
9512716-14	1998	Mutation of Cys57 (beta D5) in C-SH2 to Ile, the corresponding residue type in the p85 alpha N-SH2 domain, results in a change in peptide binding selectivity of C-SH2 towards that demonstrated by p85 alpha N-SH2.	Isoleucine	40-43	chorionic somatomammotropin hormone 2	Homo sapiens	31-36
9523865-9	1998	isoleucine, and threonine were higher in F18 and F15 than they were in B and M. Plasma concentrations of methionine, valine, and threonine were higher in F18 than in F13.	Isoleucine	0-10	mastermind like domain containing 1	Homo sapiens	41-44
9523865-10	1998	At 12 months, plasma levels of tyrosine, methionine, valine, isoleucine, and leucine were higher in F18 than they were in B + M. CONCLUSION: Many indexes of protein metabolism were similar in groups F13, B, and M, particularly at 6 months.	Isoleucine	61-71	mastermind like domain containing 1	Homo sapiens	100-103
9512716-14	1998	Mutation of Cys57 (beta D5) in C-SH2 to Ile, the corresponding residue type in the p85 alpha N-SH2 domain, results in a change in peptide binding selectivity of C-SH2 towards that demonstrated by p85 alpha N-SH2.	Isoleucine	40-43	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	83-92
9512716-14	1998	Mutation of Cys57 (beta D5) in C-SH2 to Ile, the corresponding residue type in the p85 alpha N-SH2 domain, results in a change in peptide binding selectivity of C-SH2 towards that demonstrated by p85 alpha N-SH2.	Isoleucine	40-43	chorionic somatomammotropin hormone 2	Homo sapiens	161-166
9512716-14	1998	Mutation of Cys57 (beta D5) in C-SH2 to Ile, the corresponding residue type in the p85 alpha N-SH2 domain, results in a change in peptide binding selectivity of C-SH2 towards that demonstrated by p85 alpha N-SH2.	Isoleucine	40-43	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	196-205
9425043-2	1998	The basic amphiphilic segment Arg645-Arg-Arg-His-Ile-Val-Arg-Lys-Arg-Thr654-Leu-Arg-Arg-Le u-Leu-Gln 660, located within the cytoplasmic juxtamembrane domain of this receptor, was purified as a fusion protein with glutathione S-transferase and shown to bind calmodulin in a Ca2+-dependent manner.	Isoleucine	49-52	calmodulin 1	Homo sapiens	258-268
9473309-6	1998	Based on these results, Ile-114, Arg-120, Ser-221, Ser-294, Ile-363, and Val-367 in cytochrome P450 2B4 were replaced simultaneously with Phe, His, Pro, Thr, Val, and Ala, respectively, from 2B5.	Isoleucine	24-27	cytochrome P450 2B4	Oryctolagus cuniculus	84-103
9473309-6	1998	Based on these results, Ile-114, Arg-120, Ser-221, Ser-294, Ile-363, and Val-367 in cytochrome P450 2B4 were replaced simultaneously with Phe, His, Pro, Thr, Val, and Ala, respectively, from 2B5.	Isoleucine	60-63	cytochrome P450 2B4	Oryctolagus cuniculus	84-103
9422722-6	1998	Mutations of Val-123, Leu-126, Gly-127, and Ile-128 affected the ability of PCNA to stimulate DNA synthesis by pol delta in several different assays.	Isoleucine	44-47	proliferating cell nuclear antigen	Homo sapiens	76-80
9422722-6	1998	Mutations of Val-123, Leu-126, Gly-127, and Ile-128 affected the ability of PCNA to stimulate DNA synthesis by pol delta in several different assays.	Isoleucine	44-47	DNA polymerase delta 1, catalytic subunit	Homo sapiens	111-120
9434174-7	1997	In spite of more than 86% overall aa sequence identity among the five chipmunk alpha1-AT-like proteins, they are highly divergent in the putative reactive center region; the putative P1-P1" sequences are Met-Leu (HP-55 or CM55-ML), Met-Met (CM55-MM), Met-Ser (CM55-MS), Ser-Ile (CM55-SI) and Ser-Thr (CM55-ST).	Isoleucine	274-277	serpin family A member 1	Homo sapiens	79-88
9400387-7	1997	Block of Kv2.1 channels, which carry valine, leucine, and isoleucine residues at T505, L508, and V512 equivalent sites, respectively, was not stereoselective [Kd = 8.3 mumol/L and 13 mumol/L for S(-)- and R(+)-bupivacaine, respectively].	Isoleucine	58-68	potassium voltage-gated channel subfamily B member 1	Homo sapiens	9-14
9435518-6	1997	In IPL of TNF-alpha- and LPS-treated rats a decrease of KIC oxidation and higher uptake of branched-chain amino acids (BCAA; valine, leucine, and isoleucine) were observed when compared with control animals.	Isoleucine	146-156	tumor necrosis factor	Rattus norvegicus	10-19
9351809-7	1997	The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef as the isoleucine residue of a previously described Fyn SH3 (Arg96-->lle) mutant that binds to Nef with higher affinity than the wild type.	Isoleucine	114-124	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-28
16501446-1	1997	Branched-chain amino acids (BCAA: leucine, isoleucine and valine) are not just structural constituents of proteins, but have ""pharmacologic"" properties, known for several years: BCAA are catabolized mainly in muscle; can be oxidized with energy production, being nitrogen donors for other amino acids; regulate protein synthesis and degradation; modulate metabolism of neuroactive mediators.	Isoleucine	43-53	AT-rich interaction domain 4B	Homo sapiens	28-32
16501446-1	1997	Branched-chain amino acids (BCAA: leucine, isoleucine and valine) are not just structural constituents of proteins, but have ""pharmacologic"" properties, known for several years: BCAA are catabolized mainly in muscle; can be oxidized with energy production, being nitrogen donors for other amino acids; regulate protein synthesis and degradation; modulate metabolism of neuroactive mediators.	Isoleucine	43-53	AT-rich interaction domain 4B	Homo sapiens	180-184
9374494-1	1997	A valine-to-isoleucine mutation at amino acid residue 197 of Glut2 or the equivalent residue 165 of Glut1 has been shown to impair glucose transport activity.	Isoleucine	12-22	solute carrier family 2 member 2	Homo sapiens	61-66
9374494-1	1997	A valine-to-isoleucine mutation at amino acid residue 197 of Glut2 or the equivalent residue 165 of Glut1 has been shown to impair glucose transport activity.	Isoleucine	12-22	solute carrier family 2 member 1	Homo sapiens	100-105
9385632-2	1997	We demonstrate that the capsid sequence 87His-Ala-Gly-Pro-Ile-Ala92 (87HAGPIA92) encompasses the primary cyclophilin A binding site and present an X-ray crystal structure of the CypA/HAGPIA complex.	Isoleucine	58-61	peptidylprolyl isomerase A	Homo sapiens	105-118
9385632-2	1997	We demonstrate that the capsid sequence 87His-Ala-Gly-Pro-Ile-Ala92 (87HAGPIA92) encompasses the primary cyclophilin A binding site and present an X-ray crystal structure of the CypA/HAGPIA complex.	Isoleucine	58-61	peptidylprolyl isomerase A	Homo sapiens	178-182
9351809-7	1997	The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef as the isoleucine residue of a previously described Fyn SH3 (Arg96-->lle) mutant that binds to Nef with higher affinity than the wild type.	Isoleucine	114-124	S100 calcium binding protein B	Homo sapiens	103-106
9351809-7	1997	The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef as the isoleucine residue of a previously described Fyn SH3 (Arg96-->lle) mutant that binds to Nef with higher affinity than the wild type.	Isoleucine	114-124	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	159-162
9351809-7	1997	The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef as the isoleucine residue of a previously described Fyn SH3 (Arg96-->lle) mutant that binds to Nef with higher affinity than the wild type.	Isoleucine	114-124	S100 calcium binding protein B	Homo sapiens	205-208
9355748-1	1997	Acetohydroxyacid synthase (EC 4.1.3.18) is the enzyme that catalyses the first step in the synthesis of the branched-chain amino acids valine, leucine and isoleucine.	Isoleucine	155-165	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	0-25
9344615-4	1997	Two putative cleavage sites for matrilysin within the extracellular domain of the beta 4 integrin at residues 107 (isoleucine, prior to the ligand-binding region) and 417 (leucine, prior to cysteine-rich region) are identified by sequence comparisons with known matrilysin substrates.	Isoleucine	115-125	matrix metallopeptidase 7	Homo sapiens	32-42
9299339-8	1997	Intriguingly, the RNP2 motif of the Sxl RBD1 has an Ile residue at the second position, which is generally occupied by an aromatic amino acid residue in RBDs and has been suggested to be involved in their RNA binding.	Isoleucine	52-55	Sex lethal	Drosophila melanogaster	36-39
9399579-12	1997	M-LGP85 has a protruding COOH-terminal cytoplasmic tail consisting of amino acid residues including the leucine-isoleucine sequence shown to be the lysosomal targeting signal of R-LGP85 and human LGP85 (H-LGP85).	Isoleucine	112-122	scavenger receptor class B, member 2	Mus musculus	2-7
9330225-1	1997	Human neutrophil elastase cleaves angiogenin at the Ile-29/Met-30 peptide bond to produce two major disulfide-linked fragments with apparent molecular weights of 10,000 and 4000, respectively.	Isoleucine	52-55	elastase, neutrophil expressed	Homo sapiens	6-25
9330225-1	1997	Human neutrophil elastase cleaves angiogenin at the Ile-29/Met-30 peptide bond to produce two major disulfide-linked fragments with apparent molecular weights of 10,000 and 4000, respectively.	Isoleucine	52-55	angiogenin	Homo sapiens	34-44
10660344-8	1998	Here we describe in a patient with RTH, a new mutation in codon 426 (T426I) of the TRb gene leading to a threonine to isoleucine substitution.	Isoleucine	118-128	T cell receptor beta locus	Homo sapiens	83-86
9334732-6	1997	A more commonly distributed transition causing a valine to isoleucine switch in transmembrane domain I of CCR2B (64I) with unknown functional consequences was recently shown to delay disease progression but not reduce infection risk.	Isoleucine	59-69	C-C motif chemokine receptor 2	Homo sapiens	106-111
9404730-5	1997	The response in plasma CCK-LI to administrations of 50 mM solutions of amino acids was significant (P < 0.05) for tryptophan, phenylalanine, leucine, and isoleucine and the response increased linearly (P < 0.01) with increasing amino side-chain hydrophobicity.	Isoleucine	157-167	cholecystokinin	Felis catus	23-26
9299520-2	1997	The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins.	Isoleucine	44-54	glutathione S-transferase pi 1	Homo sapiens	30-38
9299339-8	1997	Intriguingly, the RNP2 motif of the Sxl RBD1 has an Ile residue at the second position, which is generally occupied by an aromatic amino acid residue in RBDs and has been suggested to be involved in their RNA binding.	Isoleucine	52-55	l(3)62Bi	Drosophila melanogaster	40-44
9261398-4	1997	However, both HIV-1 and SIV Nef require an isoleucine located at residue 410 and the dileucine motif found at CD4 residues 413 and 414.	Isoleucine	43-53	Nef	Human immunodeficiency virus 1	28-31
9268242-3	1997	DNA sequencing analysis of the TTR gene from patient 2 showed a G to T transversion at position 3830 in exon 3, resulting in an amino acid replacement of serine-50 (Ser) with isoleucine (Ile).	Isoleucine	175-185	transthyretin	Homo sapiens	31-34
9268242-3	1997	DNA sequencing analysis of the TTR gene from patient 2 showed a G to T transversion at position 3830 in exon 3, resulting in an amino acid replacement of serine-50 (Ser) with isoleucine (Ile).	Isoleucine	187-190	transthyretin	Homo sapiens	31-34
9337644-0	1997	Functional analysis of histamine release from basophils and mast cells in subjects with the Ile-181-->Leu variant of Fc epsilon RI-beta.	Isoleucine	92-95	membrane spanning 4-domains A1	Homo sapiens	120-138
9236001-1	1997	Single-residue mutations have been made of the hydrophobic Ile or Val residue in position 8 of each of the four calcium-binding loop sequences (sites I-IV) of Drosophila calmodulin.	Isoleucine	59-62	Calmodulin	Drosophila melanogaster	170-180
9307942-3	1997	The Schiff bases of the amino acids and myoglobin were obtained by reacting the aldehyde with an excess of isoleucine, valine, lysine, methyl ester lysine and myoglobin in aqueous methanol for 18 h at room temperature.	Isoleucine	107-117	myoglobin	Homo sapiens	40-49
9268311-4	1997	The primary effect of simultaneous replacement of the adjacent Asp-279 and Ile-280 residues in IDH1 with alanines is a dramatic loss of activation by AMP.	Isoleucine	75-78	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	95-99
9268311-5	1997	In contrast, alanine replacement of the homologous Asp-286 and Ile-287 residues in IDH2 does not alter the allosteric response to AMP, but produces a 160-fold reduction in Vmax due to a 70-fold increase in the S0.5 value for NAD+.	Isoleucine	63-66	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	83-87
9268311-6	1997	These results suggest that the targeted aspartate/isoleucine residues may contribute to regulator binding in IDH1 and to cofactor binding in IDH2, i.e. that these homologous residues are located in regions that have evolved for binding the adenine nucleotide components of different ligands.	Isoleucine	50-60	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	109-113
9268311-6	1997	These results suggest that the targeted aspartate/isoleucine residues may contribute to regulator binding in IDH1 and to cofactor binding in IDH2, i.e. that these homologous residues are located in regions that have evolved for binding the adenine nucleotide components of different ligands.	Isoleucine	50-60	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	141-145
9288928-6	1997	Arg505 in COT, conserved in all reported carnitine acyltransferase sequences but replaced by asparagine or isoleucine in the choline acetyltransferases, was converted to asparagine by site-directed mutagenesis.	Isoleucine	107-117	carnitine O-octanoyltransferase	Bos taurus	10-13
9273895-4	1997	Peptide Boc-His-Pro-Phe-His-Sta-Val-Ile-His-NH2 (VI) is the best inhibitor of human renin containing Sta at position 10.	Isoleucine	36-39	renin	Homo sapiens	84-89
9323359-2	1997	Strains devoid of a functional Ilv1p have a requirement for isoleucine.	Isoleucine	60-70	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	31-36
9218437-5	1997	The predominant amino acids detected by protein sequence analysis following cleavage of insoluble elastin with HME, MME, and 92-kDa gelatinase were Leu, Ile, Ala, Gly, and Val.	Isoleucine	153-156	elastin	Homo sapiens	98-105
9218437-5	1997	The predominant amino acids detected by protein sequence analysis following cleavage of insoluble elastin with HME, MME, and 92-kDa gelatinase were Leu, Ile, Ala, Gly, and Val.	Isoleucine	153-156	membrane metalloendopeptidase	Homo sapiens	116-119
9218437-6	1997	HME and MME were similar in their substrate specificity and showed a stronger preference for Leu/Ile than did the 92-kDa enzyme.	Isoleucine	97-100	membrane metalloendopeptidase	Homo sapiens	8-11
9218437-8	1997	The amino acid residues detected in insoluble elastin following hydrolysis with porcine pancreatic elastase and human neutrophil elastase were predominantly Gly and Ala, with lesser amounts of Val, Phe, Ile, and Leu.	Isoleucine	203-206	elastin	Homo sapiens	46-53
9226420-0	1997	Decreased agonist sensitivity of human GABA(A) receptors by an amino acid variant, isoleucine to valine, in the alpha1 subunit.	Isoleucine	83-93	adrenoceptor alpha 1D	Homo sapiens	112-118
9261960-5	1997	SAA pI 8.0 was found to have isoleucine in Position 16, glutamine in Position 44 and glycine in Position 59.	Isoleucine	29-39	serum amyloid A protein	Equus caballus	0-3
9195337-1	1997	A peptide corresponding to residues 101-141 of the human nucleotide excision repair protein XPA was synthesized with an isoleucine substituted for L138 and its solution structure studied by circular dichroism and homonuclear 1H NMR spectroscopy.	Isoleucine	120-130	XPA, DNA damage recognition and repair factor	Homo sapiens	92-95
9248614-5	1997	The frequency of the phenotype combination Val/Ile at position 379 of TAP2 was decreased in patients (Pc = 1 x 10(-2)).	Isoleucine	47-50	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	70-74
9133564-2	1997	In addition to disease-associated mutations, three common amino acid polymorphisms have been identified in the HNF-1alpha gene: Ile/Leu27, Ala/Val 98, and Ser/Asn487.	Isoleucine	128-131	HNF1 homeobox A	Homo sapiens	111-121
9175749-5	1997	The purified GST-wALS was sensitive to a sulfonylurea herbicide, and was lost its sensitivity to end products, L-valine, L-leucine and L-isoleucine.	Isoleucine	135-147	glutathione S-transferase	Nicotiana tabacum	13-16
9223099-3	1997	We show here that alterations of a single amino acid at position 22 in the POU-homeodomain from the isoleucine found in Brn-3b to the valine found at the equivalent position in Brn-3a converts Brn-3b from a repressor to an activator of the SNAP-25 gene promoter.	Isoleucine	100-110	POU class 4 homeobox 2	Homo sapiens	120-126
9223099-3	1997	We show here that alterations of a single amino acid at position 22 in the POU-homeodomain from the isoleucine found in Brn-3b to the valine found at the equivalent position in Brn-3a converts Brn-3b from a repressor to an activator of the SNAP-25 gene promoter.	Isoleucine	100-110	POU class 4 homeobox 1	Homo sapiens	177-183
9223099-3	1997	We show here that alterations of a single amino acid at position 22 in the POU-homeodomain from the isoleucine found in Brn-3b to the valine found at the equivalent position in Brn-3a converts Brn-3b from a repressor to an activator of the SNAP-25 gene promoter.	Isoleucine	100-110	POU class 4 homeobox 2	Homo sapiens	193-199
9223099-3	1997	We show here that alterations of a single amino acid at position 22 in the POU-homeodomain from the isoleucine found in Brn-3b to the valine found at the equivalent position in Brn-3a converts Brn-3b from a repressor to an activator of the SNAP-25 gene promoter.	Isoleucine	100-110	synaptosome associated protein 25	Homo sapiens	240-247
9177684-2	1997	A peptide substrate, Ac-Gly-Glu-Ala-Gly-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-Tyr-Thr-Trp-Thr-L ys (biotin) -OH (Sub-1), was hydrolyzed by a recombinant NS3 proteinase fused with maltose binding protein (MBP-NS3) into a product with a free amino moiety at the N-terminus.	Isoleucine	48-51	SUB1 regulator of transcription	Homo sapiens	111-116
9177684-2	1997	A peptide substrate, Ac-Gly-Glu-Ala-Gly-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-Tyr-Thr-Trp-Thr-L ys (biotin) -OH (Sub-1), was hydrolyzed by a recombinant NS3 proteinase fused with maltose binding protein (MBP-NS3) into a product with a free amino moiety at the N-terminus.	Isoleucine	48-51	KRAS proto-oncogene, GTPase	Homo sapiens	151-154
9177684-2	1997	A peptide substrate, Ac-Gly-Glu-Ala-Gly-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-Tyr-Thr-Trp-Thr-L ys (biotin) -OH (Sub-1), was hydrolyzed by a recombinant NS3 proteinase fused with maltose binding protein (MBP-NS3) into a product with a free amino moiety at the N-terminus.	Isoleucine	48-51	KRAS proto-oncogene, GTPase	Homo sapiens	206-209
9162023-7	1997	A single mutation in which Phe-208 in MAO A was substituted by the corresponding residue of Ile in MAO B was sufficient to convert the A-type substrate selectivity, and the reverse was exactly the case.	Isoleucine	92-95	monoamine oxidase A	Rattus norvegicus	38-43
9162023-7	1997	A single mutation in which Phe-208 in MAO A was substituted by the corresponding residue of Ile in MAO B was sufficient to convert the A-type substrate selectivity, and the reverse was exactly the case.	Isoleucine	92-95	monoamine oxidase B	Rattus norvegicus	99-104
9017939-0	1997	Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans.	Isoleucine	32-42	transthyretin	Homo sapiens	17-30
9169591-6	1997	With the aid of protein engineering, a modified pro-urokinase has been prepared in which the activation sequence normally recognized by plasmin (Pro-Arg-Phe-Lys upward arrowIle-Ile-Gly-Gly) has been replaced by a sequence expected to be recognized and hydrolysed by many MMPs (Arg-Pro-Leu-Gly upward arrowIle-Ile-Gly-Gly).	Isoleucine	173-176	plasminogen	Homo sapiens	136-143
9155014-3	1997	The residues in G(M[63-75]) that interact with PP1c are those in the Arg/Lys-Val/Ile-Xaa-Phe motif that is present in almost every other identified mammalian PP1-binding subunit.	Isoleucine	81-84	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	47-51
9155014-3	1997	The residues in G(M[63-75]) that interact with PP1c are those in the Arg/Lys-Val/Ile-Xaa-Phe motif that is present in almost every other identified mammalian PP1-binding subunit.	Isoleucine	81-84	inorganic pyrophosphatase 1	Homo sapiens	47-50
9065730-8	1997	These results suggest that the structure of CYP2B1 at the site of Leu 58 rather than Ile-114 and Glu-282 plays an important role in the formation of toluene ring products, whereas in CYP2B1 Ile-114 plays an important role in the formation of benzyl alcohol.	Isoleucine	190-193	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	44-50
9065730-8	1997	These results suggest that the structure of CYP2B1 at the site of Leu 58 rather than Ile-114 and Glu-282 plays an important role in the formation of toluene ring products, whereas in CYP2B1 Ile-114 plays an important role in the formation of benzyl alcohol.	Isoleucine	190-193	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	183-189
9054627-8	1997	The rare individuals with a CYP1A1 polymorphism MspI containing an amino acid change at isoleucine had an increased level of adducts.	Isoleucine	88-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34
9110362-1	1997	Single nucleotide substitutions are known to result in a different amino acid at one of four sites in cytochrome P4502C9 (CYP2C9) namely: residue 144: Arg/Cys; residue 358: Tyr/Cys; residue 359: Ile/Leu and residue 417: Gly/Asp.	Isoleucine	195-198	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	102-120
9110362-1	1997	Single nucleotide substitutions are known to result in a different amino acid at one of four sites in cytochrome P4502C9 (CYP2C9) namely: residue 144: Arg/Cys; residue 358: Tyr/Cys; residue 359: Ile/Leu and residue 417: Gly/Asp.	Isoleucine	195-198	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	122-128
9208011-13	1997	CONCLUSION: a) The conserved glutamate (E) residue in the N-terminal domain of VIP1 and VIP2 receptors is crucial for VIP binding; b) The VIP2 receptor contains two conserved residues isoleucine 31 and threonine 274 which are critical for VIP binding while they can be mutated without loss of function in the VIP1 receptor.	Isoleucine	184-194	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	79-83
9003184-1	1997	In order to investigate the effects of an intramolecular disulfide bond on protein structure and ligand binding dynamics in myoglobin, we prepared a mutant myoglobin having a disulfide bond at the EF corner by introducing two cysteine at the position of Ile 75 and Glu 85.	Isoleucine	254-257	myoglobin	Homo sapiens	156-165
9208011-13	1997	CONCLUSION: a) The conserved glutamate (E) residue in the N-terminal domain of VIP1 and VIP2 receptors is crucial for VIP binding; b) The VIP2 receptor contains two conserved residues isoleucine 31 and threonine 274 which are critical for VIP binding while they can be mutated without loss of function in the VIP1 receptor.	Isoleucine	184-194	diphosphoinositol pentakisphosphate kinase 2	Homo sapiens	88-92
9208011-13	1997	CONCLUSION: a) The conserved glutamate (E) residue in the N-terminal domain of VIP1 and VIP2 receptors is crucial for VIP binding; b) The VIP2 receptor contains two conserved residues isoleucine 31 and threonine 274 which are critical for VIP binding while they can be mutated without loss of function in the VIP1 receptor.	Isoleucine	184-194	vasoactive intestinal peptide	Homo sapiens	79-82
9208011-13	1997	CONCLUSION: a) The conserved glutamate (E) residue in the N-terminal domain of VIP1 and VIP2 receptors is crucial for VIP binding; b) The VIP2 receptor contains two conserved residues isoleucine 31 and threonine 274 which are critical for VIP binding while they can be mutated without loss of function in the VIP1 receptor.	Isoleucine	184-194	diphosphoinositol pentakisphosphate kinase 2	Homo sapiens	138-142
9208011-13	1997	CONCLUSION: a) The conserved glutamate (E) residue in the N-terminal domain of VIP1 and VIP2 receptors is crucial for VIP binding; b) The VIP2 receptor contains two conserved residues isoleucine 31 and threonine 274 which are critical for VIP binding while they can be mutated without loss of function in the VIP1 receptor.	Isoleucine	184-194	vasoactive intestinal peptide	Homo sapiens	88-91
8962059-4	1996	Energetically important binding contacts at the interface with TF were identified in the first epidermal growth factor domain of VIIa (Gln-64, Ile-69, Phe-71, Arg-79) and in the protease domain (Arg-277, Met-306, Asp-309).	Isoleucine	143-146	coagulation factor III, tissue factor	Homo sapiens	63-65
8943295-4	1996	We prepared a set of seven single amino acid replacement mutants of rhodopsin at position 121 (G121A, Ser, Thr, Val, Ile, Leu, and Trp) and control mutants with replacements of Gly114 or Ala117.	Isoleucine	117-120	rhodopsin	Homo sapiens	68-77
8997214-6	1996	Systemically, IGF-I reduced plasma insulin, phenylalanine, tyrosine, isoleucine, and leucine in all nutrition groups.	Isoleucine	69-79	insulin-like growth factor I	Ovis aries	14-19
8939904-1	1996	A previous study using random mutagenesis identified an activating mutation in the common beta subunit (hbetac) of the human granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5 receptors in which an isoleucine residue (Ile374) in the extracellular region of hbetac is replaced by asparagine (Jenkins, B. J., D"Andrea, R., and Gonda, T. J.	Isoleucine	230-240	interleukin 3	Homo sapiens	90-188
8939904-1	1996	A previous study using random mutagenesis identified an activating mutation in the common beta subunit (hbetac) of the human granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5 receptors in which an isoleucine residue (Ile374) in the extracellular region of hbetac is replaced by asparagine (Jenkins, B. J., D"Andrea, R., and Gonda, T. J.	Isoleucine	230-240	interleukin 5	Homo sapiens	194-207
8929440-5	1996	Treatment of primary brain astrocytes with either the branched-chain amino acid (BCAA) isoleucine or the BCAA metabolite, propionate, induced MCM mRNA fourfold.	Isoleucine	87-97	methylmalonyl-CoA mutase	Homo sapiens	142-145
8910553-5	1996	Substitution of long-chain or bulky hydrophobic groups (leucines or phenylalanines) for isoleucines at positions 3 and 5 in RIIalpha decreased AKAP-binding up to 24 +/- 3 (n = 8)-fold, whereas introduction of valines had minimal effects.	Isoleucine	88-99	A-kinase anchoring protein 13	Homo sapiens	143-147
8921884-11	1996	Mutagenesis in the context of the full-length Vpr also helped identify Leu/Ile residues may be involved in maintaining the leucine-zipper-like structure.	Isoleucine	75-78	Vpr	Human immunodeficiency virus 1	46-49
8923835-7	1996	Only 2 of 30 had somatic mutations of the TSH-R (codon 632: ACC to GCC, Thr to Ala; and ACC to ATC, Thr to Ile, respectively), the latter in a patient with a thyroid hormone-producting follicular carcinoma.	Isoleucine	107-110	thyroid stimulating hormone receptor	Homo sapiens	42-47
8886002-1	1996	In some pedigrees of familial Alzheimer"s disease (FAD), three mutations of beta amyloid precursor protein (APP) have been found at the Val717 residue (to Ile, Phe, or Cly) and these mutations increase the secretion of A beta 42(43).	Isoleucine	155-158	amyloid beta precursor protein	Homo sapiens	76-106
8921884-12	1996	Mutagenesis in the context of the full-length Vpr also helped identify Leu/Ile residues critical for Vpr interaction with the cellular 180-kDa protein.	Isoleucine	75-78	Vpr	Human immunodeficiency virus 1	46-49
8921884-12	1996	Mutagenesis in the context of the full-length Vpr also helped identify Leu/Ile residues critical for Vpr interaction with the cellular 180-kDa protein.	Isoleucine	75-78	Vpr	Human immunodeficiency virus 1	101-104
20686885-2	1996	The methyl groups of Ala, Val, Leu and Ile (gamma2 only) remain highly protonated, while the remaining positions in the molecule are largely deuterated.	Isoleucine	39-42	tryptophanyl-tRNA synthetase 1	Homo sapiens	44-50
8913654-4	1996	RESULTS: Human TAP preferentially translocated analogues with residues leucine, isoleucine, methionine and arginine as the carboxy-terminal amino acids, whereas analogues with aspartic acid and serine were translocated poorly.	Isoleucine	80-90	filamin B	Homo sapiens	15-18
9001814-1	1996	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inherited metabolic disorder of isoleucine and ketone body catabolism.	Isoleucine	93-103	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38
8752159-1	1996	Human cytochrome P4501A1 (CYP1A1) occurs extrahepatically and is polymorphic, the common form having Ile at position 462 and the rare form having Val.	Isoleucine	101-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	6-24
8752159-1	1996	Human cytochrome P4501A1 (CYP1A1) occurs extrahepatically and is polymorphic, the common form having Ile at position 462 and the rare form having Val.	Isoleucine	101-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-32
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Isoleucine	174-177	parathyroid hormone	Homo sapiens	37-40
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Isoleucine	174-177	parathyroid hormone like hormone	Homo sapiens	45-50
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Isoleucine	174-177	parathyroid hormone 2	Homo sapiens	129-134
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Isoleucine	174-177	parathyroid hormone	Homo sapiens	45-48
8702701-5	1996	The results showed that two sites in PTH and PTHrP fully account for the different potencies that the two ligands exhibited with PTH-2 receptors; residue 5 (His in PTHrP and Ile in PTH) determined signaling capability, while residue 23 (Phe in PTHrP and Trp in PTH) determined binding affinity.	Isoleucine	174-177	parathyroid hormone	Homo sapiens	45-48
8692810-7	1996	Conformational stability and unfolding behavior of the Ile-20 monomer in urea gradients was found to be almost indistinguishable from that of wild-type TTR.	Isoleucine	55-58	transthyretin	Homo sapiens	152-155
8757138-7	1996	A non-conserved isoleucine in the amino-terminal flanking region covers a hydrophobic patch and stabilizes the WW domain of human YAP65 in vitro.	Isoleucine	16-26	Yes1 associated transcriptional regulator	Homo sapiens	130-135
8908357-2	1996	This C-->A mutation at nt 15452 converts the 236th residue of cytb from a leucine to isoleucine, is heteroplasmic and was observed in only 2 of 43 controls.	Isoleucine	88-98	mitochondrially encoded cytochrome b	Homo sapiens	65-69
8703980-2	1996	The derivatives are Ac-Glu[N(C18H37)2]-(Sar-Sar-Pro)n-Arg-Arg-Pro-Tyr-Ile-Leu-OH (D3nNT, n = 0,1,2,3), where a dioctadecyl group was connected to the N-terminal side of neurotensin 8-13 fragment directly or through a hydrophilic and flexible spacer chain of different lengths.	Isoleucine	70-73	neurotensin	Homo sapiens	169-180
8692688-3	1996	Here, it is shown that isoleucyl-tRNA synthetase (IleRS), which occasionally misactivates homocysteine in vitro and in vivo, catalyzes reactions of activated isoleucine with organic thiols (analogues of the side chain of homocysteine).	Isoleucine	158-168	isoleucyl-tRNA synthetase 1	Homo sapiens	23-48
8692688-3	1996	Here, it is shown that isoleucyl-tRNA synthetase (IleRS), which occasionally misactivates homocysteine in vitro and in vivo, catalyzes reactions of activated isoleucine with organic thiols (analogues of the side chain of homocysteine).	Isoleucine	158-168	isoleucyl-tRNA synthetase 1	Homo sapiens	50-55
8819144-1	1996	Neurotensin (NT, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) is a tridecapeptide that displays a wide spectrum of biological actions.	Isoleucine	62-65	neurotensin	Homo sapiens	0-11
8679537-3	1996	First, His64(E7) to Gly and Ala mutations, which open a direct channel from the solvent to the iron atom, and Phe46(CD4) to Leu, Ile, and Val mutations, which increase the mobility of the distal histidine, have little effect on the association rate constant for cyanide binding.	Isoleucine	129-132	CD4 molecule	Homo sapiens	116-119
8819144-1	1996	Neurotensin (NT, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) is a tridecapeptide that displays a wide spectrum of biological actions.	Isoleucine	62-65	neurotensin	Homo sapiens	13-15
8635257-4	1996	A single nucleotide substitution of thymidine to guanine (T1961G) changed the coding sense of HERG from isoleucine to arginine (Ile593Arg) in the channel pore region.	Isoleucine	104-114	potassium voltage-gated channel subfamily H member 2	Homo sapiens	94-98
8671651-9	1996	Instead a Pro at P3, a Phe at P7 and an Ile at P10 are utilized for MHC binding.	Isoleucine	40-43	S100 calcium binding protein A10	Homo sapiens	47-50
8819013-3	1996	These mutations result in an Arg-->Trp amino acid substitution at residue 249 and an Ile-->Phe amino acid substitution at residue 255 in a highly conserved region in the DNA-binding core domain of the p53 protein.	Isoleucine	88-91	tumor protein p53	Homo sapiens	207-210
8732754-12	1996	In trypsin, the substitution of Ile 174-Arg 175 by Gly 174-Gln 175 makes the S3 aryl site more polar because the Arg 175 side chain is directed away from thrombin and into the solvent, whereas Gln 175 is not.	Isoleucine	32-35	coagulation factor II, thrombin	Homo sapiens	154-162
8611551-5	1996	Recent mutational analysis of an isoleucyl-tRNA synthetase showed that discrimination of valine from isoleucine by amino acid activation was functionally independent of discrimination by editing.	Isoleucine	101-111	isoleucyl-tRNA synthetase 1	Homo sapiens	33-58
8621077-1	1996	The Arg-encoding triplet (AGG) in the recognition sequence Ile-Glu-Gly-Arg for factor Xa can be used to generate a StuI restriction site (AGGCCT) which greatly facilitates the construction of DNA fragments encoding fusion proteins.	Isoleucine	59-62	coagulation factor X	Homo sapiens	79-88
24178641-2	1996	The method allows quantitation of the branched chain amino acids (BCAA"s) such as leucine, isoleucine and valine and of related keto- and hydroxy acids by means of a single spectrum.	Isoleucine	91-101	AT-rich interaction domain 4B	Homo sapiens	66-70
8805247-7	1996	Peptides presented by HLA-G usually consisted of 9 amino acids, and adhered to a specific sequence motif, with anchor residues at position 2 (isoleucine or leucine), position 3 (proline) and the carboxy-terminal position 9 (leucine).	Isoleucine	142-152	major histocompatibility complex, class I, G	Homo sapiens	22-27
8639650-6	1996	The Ile-->Leu mutation seems to perturb the configuration of the metal-binding ligands at the active site so that the protein has virtually no affinity for Mg2+ yet it can still bind Mn2+ ions, though the latter only occurs when the protein is at the recognition site.	Isoleucine	4-7	mucin 7, secreted	Homo sapiens	159-162
8648177-2	1996	The most prominent of these fatty acids is 18-methyleicosanoic acid (C21a), the synthesis of which requires the oxidative decarboxylation of isoleucine.	Isoleucine	141-151	endogenous retrovirus group K member 23	Homo sapiens	69-73
8577769-7	1996	Substitution of this Ser at position -5 with Ile markedly increased binding of the insulin receptor Tyr-960 phosphopeptide to the PTB domain.	Isoleucine	45-48	insulin	Homo sapiens	83-90
8577769-7	1996	Substitution of this Ser at position -5 with Ile markedly increased binding of the insulin receptor Tyr-960 phosphopeptide to the PTB domain.	Isoleucine	45-48	polypyrimidine tract binding protein 1	Homo sapiens	130-133
8589252-1	1996	Conformational free energy calculations using an empirical potential ECEPP/3 (Empirical Conformational Energy Program for Peptides, Version 3) were carried out on angiotensin II (AII) of sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe to find the stable conformations of the free state in the unhydrated and the hydrated states.	Isoleucine	212-215	angiotensinogen	Homo sapiens	163-177
8598221-12	1996	The active region of this peptide was a sequence of Thr-Asp-Ile-Asp-Ala-Pro-Ser (TAI-DAPS), which is homologous to Leu-Asp-Val-Pro-Ser (LDVPS) derived from the active site of CS1.	Isoleucine	60-63	myozenin 2	Homo sapiens	175-178
8745396-4	1996	Docking experiments revealed that the key contacts with thrombin are hydrophobic interactions between the side chains of residues Ile 414 and Ile 424 of thrombomodulin and a hydrophobic pocket on the thrombin surface.	Isoleucine	130-133	coagulation factor II, thrombin	Homo sapiens	56-64
8745396-4	1996	Docking experiments revealed that the key contacts with thrombin are hydrophobic interactions between the side chains of residues Ile 414 and Ile 424 of thrombomodulin and a hydrophobic pocket on the thrombin surface.	Isoleucine	130-133	thrombomodulin	Homo sapiens	153-167
8745396-4	1996	Docking experiments revealed that the key contacts with thrombin are hydrophobic interactions between the side chains of residues Ile 414 and Ile 424 of thrombomodulin and a hydrophobic pocket on the thrombin surface.	Isoleucine	130-133	coagulation factor II, thrombin	Homo sapiens	200-208
8745396-4	1996	Docking experiments revealed that the key contacts with thrombin are hydrophobic interactions between the side chains of residues Ile 414 and Ile 424 of thrombomodulin and a hydrophobic pocket on the thrombin surface.	Isoleucine	142-145	coagulation factor II, thrombin	Homo sapiens	56-64
8745396-4	1996	Docking experiments revealed that the key contacts with thrombin are hydrophobic interactions between the side chains of residues Ile 414 and Ile 424 of thrombomodulin and a hydrophobic pocket on the thrombin surface.	Isoleucine	142-145	thrombomodulin	Homo sapiens	153-167
8745396-5	1996	Residues Leu 415, Phe 419, and Ile 420, which would have been buried in intact EGF-like domains, are unfavorably exposed in the complex of thrombin with the EGF-like thrombomodulin fragment, thus providing a rationale for the enhancement of binding affinity upon the deletion of Ile 420.	Isoleucine	31-34	coagulation factor II, thrombin	Homo sapiens	139-147
8745396-5	1996	Residues Leu 415, Phe 419, and Ile 420, which would have been buried in intact EGF-like domains, are unfavorably exposed in the complex of thrombin with the EGF-like thrombomodulin fragment, thus providing a rationale for the enhancement of binding affinity upon the deletion of Ile 420.	Isoleucine	31-34	thrombomodulin	Homo sapiens	166-180
8573072-8	1996	When the target sequence of the restriction protease factor Xa (Ile-Glu-Gly-Arg) was used as the linker between maltose-binding protein and human phenylalanine hydroxylase, cleavage of the fusion protein gave a mixture of full-length hydroxylase and a truncated form of the enzyme lacking the 13 N-terminal residues.	Isoleucine	64-68	coagulation factor X	Homo sapiens	53-62
8573072-8	1996	When the target sequence of the restriction protease factor Xa (Ile-Glu-Gly-Arg) was used as the linker between maltose-binding protein and human phenylalanine hydroxylase, cleavage of the fusion protein gave a mixture of full-length hydroxylase and a truncated form of the enzyme lacking the 13 N-terminal residues.	Isoleucine	64-68	phenylalanine hydroxylase	Homo sapiens	146-171
8573103-7	1996	Point mutations of Thr-10 to Arg and Tyr-13 to Ile greatly lowered MCP-1 activity.	Isoleucine	47-50	C-C motif chemokine ligand 2	Homo sapiens	67-72
9575343-1	1996	Analogs of the peptide Val-Thr-Val-Ala-Pro-Val-His-Ile, derived from the primary sequence of the acute phase reactant CRP, i.e. amino acid residues 89-96, were optimized to inhibit the enzymatic activities of human leukocyte elastase (hLE) and human leukocyte cathepsin G (hCG), which are associated with tissue damage occurring in the course of several chronic inflammatory conditions.	Isoleucine	51-54	C-reactive protein	Homo sapiens	118-121
8672466-16	1996	These show persistent interactions of TRH with Ile 109 and Ile 116 in HX 3 and with Tyr310 and Ser313 in HX 7, which will be tested to refine the structure of the ligand-receptor complex.	Isoleucine	47-50	thyrotropin releasing hormone	Homo sapiens	38-41
8672466-16	1996	These show persistent interactions of TRH with Ile 109 and Ile 116 in HX 3 and with Tyr310 and Ser313 in HX 7, which will be tested to refine the structure of the ligand-receptor complex.	Isoleucine	59-62	thyrotropin releasing hormone	Homo sapiens	38-41
9150873-10	1996	In polyphenylalanine synthesis programmed by polyuridylic acid, misincorporation of isoleucine, leucine or a mixture of amino acids was stimulated upto 17-fold when RRF was omitted from the in vitro system.	Isoleucine	84-94	mitochondrial ribosome recycling factor	Homo sapiens	165-168
9575343-1	1996	Analogs of the peptide Val-Thr-Val-Ala-Pro-Val-His-Ile, derived from the primary sequence of the acute phase reactant CRP, i.e. amino acid residues 89-96, were optimized to inhibit the enzymatic activities of human leukocyte elastase (hLE) and human leukocyte cathepsin G (hCG), which are associated with tissue damage occurring in the course of several chronic inflammatory conditions.	Isoleucine	51-54	elastase, neutrophil expressed	Homo sapiens	235-238
9007616-4	1996	DNA sequence analysis of the LCAT gene showed an A-to-T transition at base 97 in exon 1, and predicted a change in asparagine to isoleucine at the 5th amino acid of the protein.	Isoleucine	129-139	lecithin-cholesterol acyltransferase	Homo sapiens	29-33
8753852-4	1996	These results confirmed previous findings that Tyr and Phe at P2 as well as Phe, Trp, Ile, and Leu at the C-terminus were main anchor residues for HLA-A*2402.	Isoleucine	86-89	major histocompatibility complex, class I, A	Homo sapiens	147-152
8543141-1	1995	A T-to-C substitution, replacing a hydrophobic isoleucine residue with a hydrophilic threonine residue in position 100 of a mature protein molecule, was found at codon 117 of the GM-CSF gene.	Isoleucine	47-57	colony stimulating factor 2	Homo sapiens	179-185
8827569-4	1996	EGF treatment stimulated 14C-aminoisobutyric acid, isoleucine and alanine uptake by placental explants as did treatment with insulin-like growth factor-1 and insulin, which have been reported to stimulate the active amino acid transport.	Isoleucine	51-61	epidermal growth factor like 1	Rattus norvegicus	0-3
7495881-5	1995	Deletion of BAP2 reduced uptake of leucine, isoleucine and valine by 25-50%, while the uptake of 8 other L-alpha-amino acids was unaltered or slightly increased.	Isoleucine	44-54	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	12-16
7495881-6	1995	Introduction of BAP2 on a centromere-based vector, leading to a gene dosage of two or slightly more, caused a 50% increase in leucine uptake and a smaller increase for isoleucine and valine.	Isoleucine	168-178	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	16-20
9383482-3	1995	A polypeptide representing the relevant sequence from the alpha-subunit of the nAChR (Ac-Tyr-Cys-Glu-Ile-Ile-Val-Thr-His-Phe-Pro-Phe-Asp-Gln-Gln Asn-Cys-Thr-NH2) is small enough to allow detailed structural analysis, which may provide insight into the role of glycosylation in the maturation process that leads to ion-channel assembly.	Isoleucine	101-104	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	79-84
9383482-3	1995	A polypeptide representing the relevant sequence from the alpha-subunit of the nAChR (Ac-Tyr-Cys-Glu-Ile-Ile-Val-Thr-His-Phe-Pro-Phe-Asp-Gln-Gln Asn-Cys-Thr-NH2) is small enough to allow detailed structural analysis, which may provide insight into the role of glycosylation in the maturation process that leads to ion-channel assembly.	Isoleucine	105-108	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	79-84
7495881-7	1995	However, when the 29 C-terminal codons of the plasmid-borne copy of BAP2 were substituted, the cells more than doubled the uptake of leucine, isoleucine and valine, while no or little increase in uptake was observed for the other 8 amino acids.	Isoleucine	142-152	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	68-72
7665623-9	1995	The Ile-87 IR enhanced the insulin binding affinity about 4-fold.	Isoleucine	4-7	insulin receptor	Homo sapiens	11-13
7665623-9	1995	The Ile-87 IR enhanced the insulin binding affinity about 4-fold.	Isoleucine	4-7	insulin	Homo sapiens	27-34
7665623-11	1995	In addition, the dissociation of insulin in Ile-87 IR was slower than in Leu-87 IR, but in Ala-87 IR it was more rapid.	Isoleucine	44-47	insulin	Homo sapiens	33-40
7665623-11	1995	In addition, the dissociation of insulin in Ile-87 IR was slower than in Leu-87 IR, but in Ala-87 IR it was more rapid.	Isoleucine	44-47	insulin receptor	Homo sapiens	51-53
7627950-2	1995	A CYP1A1 polymorphism (isoleucine to valine substitution in exon 7) or the null allele for GSTM1 may affect the mutagenic potential of polycyclic aromatic hydrocarbons.	Isoleucine	23-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	2-8
7657595-7	1995	Since amino acids 405-419 on a human RAR alpha (hRAR alpha) are predicted to form a short amphipathic alpha-helix, modeling of this structure into a helical wheel indicates that these two amino acids, methionine 406 and isoleucine 410, are actually positioned proximal to each other.	Isoleucine	220-230	retinoic acid receptor alpha	Homo sapiens	37-46
7657595-7	1995	Since amino acids 405-419 on a human RAR alpha (hRAR alpha) are predicted to form a short amphipathic alpha-helix, modeling of this structure into a helical wheel indicates that these two amino acids, methionine 406 and isoleucine 410, are actually positioned proximal to each other.	Isoleucine	220-230	retinoic acid receptor alpha	Homo sapiens	48-58
7657595-8	1995	Data presented here suggest that high affinity 9-cis-RA binding to a hRAR alpha depends on an interaction with the two amino acids methionine 406 and isoleucine 410.	Isoleucine	150-160	retinoic acid receptor alpha	Homo sapiens	69-79
7546226-6	1995	Adduct levels were also lower in the nine subjects heterozygous or homozygous for the CYP1A1 exon 7 polymorphism (which codes for a valine rather than isoleucine and is thought to be associated with greater CYP1A1 activity) compared with the 38 wild-type subjects (P = 0.12).	Isoleucine	151-161	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	86-92
8537177-3	1995	The substitution of the human relaxin II sequence (His-Val-Gly; A12-14) by the corresponding insulin sequence (Thr-Ser-Ile) or the hydrocarbon chain of omega-aminooctanoic acid (Aoc) caused significant loss of biological activity.	Isoleucine	119-122	insulin	Homo sapiens	93-100
7638622-3	1995	A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds.	Isoleucine	62-72	presenilin 2	Homo sapiens	20-24
7642551-6	1995	Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K.	Isoleucine	57-60	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	108-114
7581380-7	1995	In addition, we report a novel Ile-290-Met CLCN1 mutation for a typical Thomsen pedigree.	Isoleucine	31-34	chloride voltage-gated channel 1	Homo sapiens	43-48
7495741-5	1995	Interestingly, upstream of the promoter in the antisense strand, an open reading frame has been found that codes for a small molecular weight protein (approximately 60 amino acids) that contains a proline-rich region and a tyrosine-isoleucine motif that has homology to Ig beta (the B29 gene product).	Isoleucine	232-242	CD79B antigen	Mus musculus	270-277
7635535-6	1995	Sequence comparison among the two rat strains revealed a mutation in the coding region of the angiotensinogen gene that results in an isoleucine-to-valine substitution in SHRSP at amino acid position 154 (I154V).	Isoleucine	134-144	angiotensinogen	Rattus norvegicus	94-109
7495741-5	1995	Interestingly, upstream of the promoter in the antisense strand, an open reading frame has been found that codes for a small molecular weight protein (approximately 60 amino acids) that contains a proline-rich region and a tyrosine-isoleucine motif that has homology to Ig beta (the B29 gene product).	Isoleucine	232-242	CD79B antigen	Mus musculus	283-286
7626627-3	1995	Monoclonal antibody MB19 identifies a common polymorphism in apoB, an Ile/Thr substitution at residue 71, by binding with a 60-fold higher affinity to apoB(Ile71)-containing LDL.	Isoleucine	70-73	apolipoprotein B	Homo sapiens	61-65
7645223-6	1995	The leucine/isoleucine residues of the SIVmac239 Rev activation domain appeared to be of similar importance for function.	Isoleucine	12-22	Rev	Human immunodeficiency virus 1	49-52
7626627-3	1995	Monoclonal antibody MB19 identifies a common polymorphism in apoB, an Ile/Thr substitution at residue 71, by binding with a 60-fold higher affinity to apoB(Ile71)-containing LDL.	Isoleucine	70-73	apolipoprotein B	Homo sapiens	151-155
7779775-8	1995	The mutant W3A (Trp-3 to Ala) also showed decreased rates of hydrolysis but to a lesser extent than Ile-9 and Phe-5 mutants.	Isoleucine	100-103	transient receptor potential cation channel subfamily C member 3	Bos taurus	16-21
7537780-3	1995	We have determined that a T-->G substitution mutation in keratin 5, which results in a Ile-->Ser change at codon 161, is common among patients with the Weber-Cockayne disease variant, accounting for six of 13 cases tested.	Isoleucine	90-93	keratin 5	Homo sapiens	60-69
7751638-2	1995	According to the peptide motif of HLA-B*3501, aliphatic hydrophobic (Leu, Ile, and Met) or aromatic residues (Tyr and Phe) specify the main anchor at the C terminus, and position 2 renders an auxiliary anchor for proline.	Isoleucine	74-77	major histocompatibility complex, class I, B	Homo sapiens	34-39
8612192-1	1995	Three kinds of missense mutation at codon 717 of amyloid precursor protein (APP) gene (Val --> Ile; Val --> Gly; Val --> Phe) were screened in 114 patients with familial and sporadic Alzheimer"s disease (AD), using a rapid testing method for each Val --> Gly and Val --> Phe mutation and Goate"s method for Val --> Ile mutation based on the polymerase chain reaction.	Isoleucine	95-98	amyloid beta precursor protein	Homo sapiens	49-74
8612192-1	1995	Three kinds of missense mutation at codon 717 of amyloid precursor protein (APP) gene (Val --> Ile; Val --> Gly; Val --> Phe) were screened in 114 patients with familial and sporadic Alzheimer"s disease (AD), using a rapid testing method for each Val --> Gly and Val --> Phe mutation and Goate"s method for Val --> Ile mutation based on the polymerase chain reaction.	Isoleucine	315-318	amyloid beta precursor protein	Homo sapiens	49-74
7755557-12	1995	Experiments with isoleucine-containing analogues of (Gly-Hyp-Leu)4 showed that thimet oligopeptidase preferred to cleave these peptides near the C-terminus.	Isoleucine	17-27	thimet oligopeptidase 1	Homo sapiens	79-100
7737993-5	1995	In a recent study, we have shown that GroEL interacts preferentially with the side chains of hydrophobic amino acids (Ile, Phe, Val, Leu, and Trp) and more weakly with several polar or charged amino acids, including the strongest alpha-helix and beta-sheet formers (Glu, Gln, His, Thr, and Tyr).	Isoleucine	118-121	heat shock protein family D (Hsp60) member 1	Homo sapiens	38-43
7616165-0	1995	A mixture of the branched chain amino acids leucine, isoleucine and valine increases ovulation rate in ewes when infused during the late luteal phase of the oestrous cycle: an effect that may be mediated by insulin.	Isoleucine	53-63	LOC105613195	Ovis aries	207-214
7613465-8	1995	The binding of the inhibitory peptide cTnIp, corresponding to Asn 129 through Ile 149 of cTnI, to both 2Ca(2+)-loaded and Ca(2+)-saturated cTnC was shown to protect Met residues 120 and 157 from HyTEMPO as determined by a decrease in their measured R1 values.	Isoleucine	78-81	troponin I3, cardiac type	Homo sapiens	38-43
7783849-2	1995	In the present paper we examined the expression of MCH mRNA and pro-MCH-derived peptides, i.e. MCH and neuropeptide-(N)-glutamic acid (E) isoleucine (I) amide (NEI), in peripheral tissues of adult rodents.	Isoleucine	138-148	pro-melanin-concentrating hormone	Rattus norvegicus	64-71
7613465-8	1995	The binding of the inhibitory peptide cTnIp, corresponding to Asn 129 through Ile 149 of cTnI, to both 2Ca(2+)-loaded and Ca(2+)-saturated cTnC was shown to protect Met residues 120 and 157 from HyTEMPO as determined by a decrease in their measured R1 values.	Isoleucine	78-81	troponin I3, cardiac type	Homo sapiens	38-42
7613465-8	1995	The binding of the inhibitory peptide cTnIp, corresponding to Asn 129 through Ile 149 of cTnI, to both 2Ca(2+)-loaded and Ca(2+)-saturated cTnC was shown to protect Met residues 120 and 157 from HyTEMPO as determined by a decrease in their measured R1 values.	Isoleucine	78-81	troponin C1, slow skeletal and cardiac type	Homo sapiens	139-143
7708669-6	1995	Based on this structural evidence, H-2Kb has at least two submotifs: one with Tyr at P5 (or P6 for nonamer peptides) and a small residue at P2 (i.e., Ala or Gly) and another with Phe at P5 and a medium-sized hydrophobic residue at P2 (i.e., Ile).	Isoleucine	241-244	histocompatibility 2, K1, K region	Mus musculus	35-40
7696307-8	1995	These fractions consisted of the 95-residue proform of colipase and of fragment 1-93, respectively, both specifically cleaved at the Ile79-Thr80 peptide bond with partial removal of isoleucine at position 79 and serine at position 78.	Isoleucine	182-192	colipase	Homo sapiens	55-84
7896796-7	1995	The amino-terminal incompatibility site was identified as position 5 (Ile in PTH and His in PTHrP), because Ile5-hybrid-1 bound with high affinity (IC50 approximately equal to 20 nM).	Isoleucine	70-73	parathyroid hormone	Rattus norvegicus	77-80
7893699-7	1995	EPR and EXAFS studies of oxidized PHM indicate that the active site contains type 2 copper in a tetragonal environment; the copper is coordinated to two to three His and one to two additional O/N ligands, probably solvent, again supporting the structural homology of PHM and D beta M. Mutation of the Met residues common to PHM and D beta M to Ile identified Met314 as critical for catalytic activity.	Isoleucine	344-347	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	34-37
7890717-6	1995	MMP-2 cleaves at the same Gly-Ile/Leu bond in the collagen alpha chains as interstitial collagenases with kcat and Km values similar to that of MMP-1.	Isoleucine	30-33	matrix metallopeptidase 2	Homo sapiens	0-5
7775860-16	1995	Apart from other differences, amino acid composition analysis shows that hedgehog apoA-I contains four isoleucine residues, while this amino acid is totally absent from the corresponding protein in higher mammals.	Isoleucine	103-113	apolipoprotein A1	Homo sapiens	82-88
7479689-9	1995	The results are consistent with a model in which two amino acids of 15-lipoxygenase (isoleucine 417 and methionine 418) constitute a structural element which contributes to the regiospecificity of the enzyme.	Isoleucine	85-95	arachidonate 15-lipoxygenase	Homo sapiens	68-83
7655862-4	1995	"G6PD Riley" was due to a T-->C transition at cDNA nucleotide 1139 also changing the 380 isoleucine, in this case to a threonine.	Isoleucine	92-102	glucose-6-phosphate dehydrogenase	Homo sapiens	1-5
7829531-13	1995	It is possible that the aliphatic side chains of Val20 and Leu21 interact with the essential Leu and Ile residues in the AKAP75 tethering region.	Isoleucine	101-104	A-kinase anchoring protein 5	Homo sapiens	121-127
7813820-5	1995	SSCP analysis of the ISPK-1 gene identified one silent polymorphism at codon 266 and one amino acid variant at codon 38 (Ile-->Ser).	Isoleucine	121-124	ribosomal protein S6 kinase A3	Homo sapiens	21-27
7634379-3	1995	Treatment with L-amino acid oxidase (LOX) significantly depleted murine plasma LNAAs: phenylalanine, leucine, and tyrosine (> 95%); methionine (83%); isoleucine (70%); and valine (46%).	Isoleucine	153-163	interleukin 4 induced 1B	Mus musculus	15-35
7634379-3	1995	Treatment with L-amino acid oxidase (LOX) significantly depleted murine plasma LNAAs: phenylalanine, leucine, and tyrosine (> 95%); methionine (83%); isoleucine (70%); and valine (46%).	Isoleucine	153-163	interleukin 4 induced 1B	Mus musculus	37-40
7601731-8	1995	Infusion of 2,3-DHP resulted in a plasma 2,3-DHP content of 9.4 mumol/L and increased plasma THR, ARG, VAL, PHE, ILE, LEU, and LYS concentrations (P < .10).	Isoleucine	113-116	dihydropyrimidinase	Homo sapiens	16-19
12228340-1	1995	Threonine dehydratase/deaminase (TD), the first enzyme in the isoleucine biosynthetic pathway, is feedback inhibited by isoleucine.	Isoleucine	62-72	L-O-methylthreonine resistant 1	Arabidopsis thaliana	0-31
12228340-1	1995	Threonine dehydratase/deaminase (TD), the first enzyme in the isoleucine biosynthetic pathway, is feedback inhibited by isoleucine.	Isoleucine	62-72	L-O-methylthreonine resistant 1	Arabidopsis thaliana	33-35
12228340-1	1995	Threonine dehydratase/deaminase (TD), the first enzyme in the isoleucine biosynthetic pathway, is feedback inhibited by isoleucine.	Isoleucine	120-130	L-O-methylthreonine resistant 1	Arabidopsis thaliana	0-31
12228340-1	1995	Threonine dehydratase/deaminase (TD), the first enzyme in the isoleucine biosynthetic pathway, is feedback inhibited by isoleucine.	Isoleucine	120-130	L-O-methylthreonine resistant 1	Arabidopsis thaliana	33-35
12228340-5	1995	Biochemical characteristics (specific activities, Km, Vmax, and pH optimum) of TD in extracts from the wild type and GM11b were similar except for the inhibition constant of isoleucine, which was 50-fold higher in GM11b than in the wild type.	Isoleucine	174-184	L-O-methylthreonine resistant 1	Arabidopsis thaliana	79-81
7696618-3	1994	Comparison of genomic and cDNA sequences revealed extensive editing of the human EAA4 (GluR6) mRNA at the isoleucine/valine, tyrosine/cysteine sites of the transmembrane I region, and the glutamine/arginine site of the transmembrane II region.	Isoleucine	106-116	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	81-85
7696618-3	1994	Comparison of genomic and cDNA sequences revealed extensive editing of the human EAA4 (GluR6) mRNA at the isoleucine/valine, tyrosine/cysteine sites of the transmembrane I region, and the glutamine/arginine site of the transmembrane II region.	Isoleucine	106-116	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	87-92
7528239-5	1994	Sequence analysis identified a single base change in the amino-terminal V1 variable subdomain of keratin 1, which caused a lysine to isoleucine substitution.	Isoleucine	133-143	keratin 1	Homo sapiens	97-106
7966596-6	1994	Viruses encoding Ile, Leu, or Val at E2 1 contained the uncleaved form of PE2.	Isoleucine	17-20	ETS2 repressor factor	Homo sapiens	74-77
7961722-3	1994	Subsequent site-directed mutagenesis experiments identified amino acid 270 (isoleucine/methionine, bovine/canine) as being primarily responsible for species differences in the binding of N6-adenine-substituted compounds, R-N6-phenylisopropyladenosine (R-PIA) and (S)-N6-endonorbornan-2-yl-9-methyladenine, and the C-8-substituted xanthine, [3H]cyclopentyl-1,3-dipropylxanthine.	Isoleucine	76-86	RPIA	Canis lupus familiaris	221-257
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Isoleucine	103-106	angiotensinogen	Homo sapiens	71-85
7775978-2	1995	Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings.	Isoleucine	177-180	angiotensinogen	Homo sapiens	135-149
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Isoleucine	103-106	angiotensinogen	Homo sapiens	71-84
7918443-9	1994	Computer graphics of the three-dimensional structure of beta 2M suggested that the high specificity for the glycated site at Ile-1 may be explained by its high solvent accessibility and the nearby imidazole group of His-31 as an acid-base catalyst of the Amadori rearrangement.	Isoleucine	125-128	beta-2-microglobulin	Homo sapiens	56-63
8089102-0	1994	The Ile-84-->Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein.	Isoleucine	4-7	transthyretin	Homo sapiens	47-60
7935404-3	1994	We have previously found that a valine-to-isoleucine point mutation at position 157 (V157I mutant) within the tyrosine kinase domain of this truncated erbB can dramatically activate the sarcomagenic potential of the oncogene and increase the kinase activity of this oncoprotein.	Isoleucine	42-52	epidermal growth factor receptor	Homo sapiens	151-155
7935404-12	1994	When the valine-to-isoleucine substitution was put in context of the full-length erbB protein, the mutation relaxed the ligand dependence and had a positive effect on the transforming potential of the full-length c-erbB.	Isoleucine	19-29	epidermal growth factor receptor	Homo sapiens	81-85
7935404-12	1994	When the valine-to-isoleucine substitution was put in context of the full-length erbB protein, the mutation relaxed the ligand dependence and had a positive effect on the transforming potential of the full-length c-erbB.	Isoleucine	19-29	epidermal growth factor receptor	Homo sapiens	215-219
7937106-10	1994	Thus, the v-ets B mutation highlights the isoleucine 445 as an essential amino acid of the c-ets-1 and c-ets-2 DNA-binding domains.	Isoleucine	42-52	ETS proto-oncogene 1, transcription factor	Homo sapiens	91-98
7937106-10	1994	Thus, the v-ets B mutation highlights the isoleucine 445 as an essential amino acid of the c-ets-1 and c-ets-2 DNA-binding domains.	Isoleucine	42-52	ETS proto-oncogene 2, transcription factor	Homo sapiens	105-110
8089102-0	1994	The Ile-84-->Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein.	Isoleucine	4-7	retinol binding protein 4	Homo sapiens	105-128
8089102-2	1994	The Ile-84-->Ser mutation and several other point mutations in TTR are associated with familial amyloidotic polyneuropathy, which is characterized by extracellular depositions of amyloid fibrils mainly consisting of mutated TTRs.	Isoleucine	4-7	transthyretin	Homo sapiens	66-69
8089102-5	1994	This result indicates the participation of a region on the outer surface of TTR that comprises Ile-84 in the recognition of RBP.	Isoleucine	95-98	transthyretin	Homo sapiens	76-79
7937783-5	1994	Like several other cGK sequences, that of cGK II contained a leucine/isoleucine heptad repeat motif that has been implicated in dimer formation in cGK I.	Isoleucine	69-79	protein kinase cGMP-dependent 2	Rattus norvegicus	42-48
7937783-5	1994	Like several other cGK sequences, that of cGK II contained a leucine/isoleucine heptad repeat motif that has been implicated in dimer formation in cGK I.	Isoleucine	69-79	protein kinase cGMP-dependent 1	Homo sapiens	42-47
8089102-5	1994	This result indicates the participation of a region on the outer surface of TTR that comprises Ile-84 in the recognition of RBP.	Isoleucine	95-98	retinol binding protein 4	Homo sapiens	124-127
7811002-7	1994	Mutations were found in three of nine isolates tested; these mutations caused the following alterations in the sequence of GyrA: Asp at position 87 (Asp-87) to Asn, Asp-87 to Tyr, and Thr-83 to Ile.	Isoleucine	194-197	DNA gyrase subunit A	Pseudomonas aeruginosa PAO1	123-127
7948726-13	1994	The exosite of thrombin appears to be very specific to both the backbone and the side-chain conformations of the hirudin C-terminal peptides, especially those of residues Phe(56) and Ile(59).	Isoleucine	183-186	coagulation factor II, thrombin	Homo sapiens	15-23
7852289-10	1994	Therefore, these results suggested that continuous internalization from the cell surface and lysosomal transport of of endogenous LGP85 occur through a mechanism that can recognize this novel amino acid sequence, probably a Leu-Ile-containing motif, in normal hepatic cells of rat.	Isoleucine	228-231	scavenger receptor class B, member 2	Rattus norvegicus	130-135
8063791-5	1994	The wild type yeast Ras2 protein terminates in the sequence Cys-Cys-Ile-Ile-Ser.	Isoleucine	68-71	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	20-24
8063791-5	1994	The wild type yeast Ras2 protein terminates in the sequence Cys-Cys-Ile-Ile-Ser.	Isoleucine	72-75	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	20-24
8068029-0	1994	Effects of mutating Asn-52 to isoleucine on the haem-linked properties of cytochrome c. Asn-52 of rat cytochrome c and baker"s yeast iso-1-cytochrome c was changed to isoleucine by site-directed mutagenesis and the mutated proteins expressed in and purified from cultures of transformed yeast.	Isoleucine	30-40	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	133-138
7949246-2	1994	We prepared three peptides derived from the type III connecting segment domain (IIICS) of fibronectin: Glu-Ile-Leu-Asp-Val (EILDV), Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (EILDVPST), Arg-Glu-Asp-Val (REDV), and a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg (YIGSR).	Isoleucine	107-110	fibronectin 1	Homo sapiens	90-101
7798168-10	1994	111, 2341-2351 (1990)] have reported that Pro-11, Gly-170, and Ile-340 in normal human AGT1 were replaced by Leu, Arg, and Met, respectively, in a patient with primary hyperoxaluria type 1.	Isoleucine	63-66	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	87-91
8052624-10	1994	The amino acid sequence surrounding the amino terminus of the enterokinase light chain is ITPK-IVGG (human) or VSPK-IVGG (bovine), suggesting that single-chain enterokinase is activated by an unidentified trypsin-like protease that cleaves the indicated Lys-Ile bond.	Isoleucine	258-261	transmembrane serine protease 15	Bos taurus	62-74
8052624-10	1994	The amino acid sequence surrounding the amino terminus of the enterokinase light chain is ITPK-IVGG (human) or VSPK-IVGG (bovine), suggesting that single-chain enterokinase is activated by an unidentified trypsin-like protease that cleaves the indicated Lys-Ile bond.	Isoleucine	258-261	transmembrane serine protease 15	Bos taurus	160-172
8034645-6	1994	Acetylation or carbamylation of the alpha-amino group of the NH2-terminal Ile-153 of VIIa resulted in the loss of binding affinity for TF; such modifications convert VIIa into a zymogen-like inactive form by destroying the salt bridge between Ile-153 and Asp-343 in VIIa.	Isoleucine	74-77	LOC101909187	Bos taurus	135-137
8034645-9	1994	Therefore, binding of TF with the heavy chain of VIIa may induce a conformational change that brings the alpha-amino group of Ile-153 close to the beta-carboxyl group of Asp-343 to make a stable salt bridge.	Isoleucine	126-129	LOC101909187	Bos taurus	22-24
8043603-9	1994	Regarding the physical properties, chimeric enzymes bearing residues 12-53 of PRS I were stable at 49 degrees C and with digestion with papain and proteinase K. Our observations suggest that Lys-17, Ile-18, and/or Cys-40 of PRS I contribute to stability of the enzyme.	Isoleucine	199-202	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	78-83
8016122-5	1994	Therefore, the segments Ile-163-Gly-354 and Lys-712-Ser-830 of the SERCA1 ATPase are sufficient for Ca2+ and thapsigargin sensitivity.	Isoleucine	24-27	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	Gallus gallus	67-73
7974349-3	1994	The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII.	Isoleucine	154-157	von Willebrand factor	Homo sapiens	63-66
7974349-3	1994	The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII.	Isoleucine	154-157	coagulation factor VIII	Homo sapiens	70-81
7974349-3	1994	The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII.	Isoleucine	154-157	coagulation factor VIII	Homo sapiens	83-88
7974349-3	1994	The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII.	Isoleucine	154-157	von Willebrand factor	Homo sapiens	168-171
8188678-7	1994	Mutagenesis and deletion of the highly conserved lipoxygenase C-terminal isoleucine (Ile663), a residue believed to be involved in the non-heme iron atom coordination of all lipoxygenases, was performed.	Isoleucine	73-83	linoleate 9S-lipoxygenase-4	Glycine max	49-61
8197131-4	1994	After sequencing tyrosinase cDNA isolated from c44H/c44H homozygotes, we uncovered a single base alteration from wild type leading to a serine-to-isoleucine exchange.	Isoleucine	146-156	tyrosinase	Mus musculus	17-27
8168623-2	1994	The mutations in both strains alter the initiating methionine codon in the ATP5 gene: ATG to ATA (Ile) and AAG (Lys).	Isoleucine	98-101	F1F0 ATP synthase subunit 5	Saccharomyces cerevisiae S288C	75-79
7915226-6	1994	One allele (NAT2(191)) contained a point mutation at nucleotide 191 [G-->A (Arg-->Gln)], whereas the other allele (NAT2(341/803)) contained two point mutations [341T-->C (Ile-->Thr); 803A-->G (Lys-->Arg)].	Isoleucine	180-183	N-acetyltransferase 2	Homo sapiens	12-16
8175738-4	1994	Conversely, exchange of the glycine A14 residue in relaxin, which corresponds to the insulin position A10 for isoleucine, reduced the bio-activity and the receptor binding capacity of relaxin about 100-fold.	Isoleucine	110-120	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	36-39
8175738-4	1994	Conversely, exchange of the glycine A14 residue in relaxin, which corresponds to the insulin position A10 for isoleucine, reduced the bio-activity and the receptor binding capacity of relaxin about 100-fold.	Isoleucine	110-120	insulin	Homo sapiens	85-92
8175738-4	1994	Conversely, exchange of the glycine A14 residue in relaxin, which corresponds to the insulin position A10 for isoleucine, reduced the bio-activity and the receptor binding capacity of relaxin about 100-fold.	Isoleucine	110-120	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	102-105
8181745-3	1994	The aa sequences are identical, except at position 78, where Rpl3-1 displays a valine residue and Rpl3-2 contains isoleucine.	Isoleucine	114-124	ribosomal 60S subunit protein L3	Saccharomyces cerevisiae S288C	98-102
8157690-1	1994	Tyrosines 292 and 293 in the mammalian glucose transporter GLUT1 have been substituted by either isoleucine or phenylalanine.	Isoleucine	97-107	solute carrier family 2 member 1	Homo sapiens	59-64
8172593-1	1994	The residue asparagine-52 of rat cytochrome c and baker"s yeast iso-1-cytochrome c was mutated to isoleucine by site-directed mutagenesis, and the unfolding of the wild-type and mutant proteins in urea or guanidinium chloride solutions was studied.	Isoleucine	98-108	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	64-69
8157690-7	1994	These data indicated that the Tyr-293-->Ile substitution produced no change in the affinity for D-glucose, a relatively small enhancement in the affinity for exofacial ligands, but a large approximately 300-fold reduction in affinity for cytochalasin B, suggesting that the mutated GLUT1 is locked in an outward facing conformation.	Isoleucine	43-46	solute carrier family 2 member 1	Homo sapiens	285-290
8144631-11	1994	Comparisons between peptide sequences suggest that the N-terminal SH2 domain of SH-PTP2 binds with highest affinity to phosphotyrosine (pY) followed by a beta-branched residue (Val, Ile, Thr) at pY+1 and a hydrophobic residue (Val, Leu, Ile) at pY+3 positions.	Isoleucine	182-185	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	80-87
8147927-2	1994	METHODS: TAP2 polymorphic residues at 3 sites, Val/Ile-379, Ala/Thr-565, and Ala/Thr-665, were characterized by amplification refractory mutation system polymerase chain reaction in 185 RA patients and 48 HLA-DR4 positive healthy controls.	Isoleucine	51-54	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	9-13
8147927-4	1994	RESULTS: The frequencies of Ile-379, Thr-565, and Thr-665 were significantly increased in DR4 positive versus DR4 negative RA patients.	Isoleucine	28-31	major histocompatibility complex, class II, DR beta 4	Homo sapiens	90-93
8147927-4	1994	RESULTS: The frequencies of Ile-379, Thr-565, and Thr-665 were significantly increased in DR4 positive versus DR4 negative RA patients.	Isoleucine	28-31	major histocompatibility complex, class II, DR beta 4	Homo sapiens	110-113
8144631-11	1994	Comparisons between peptide sequences suggest that the N-terminal SH2 domain of SH-PTP2 binds with highest affinity to phosphotyrosine (pY) followed by a beta-branched residue (Val, Ile, Thr) at pY+1 and a hydrophobic residue (Val, Leu, Ile) at pY+3 positions.	Isoleucine	237-240	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	80-87
7510680-0	1994	Lipopolysaccharide (LPS) binding protein, truncated at Ile-197, binds LPS but does not transfer LPS to CD14.	Isoleucine	55-58	lipopolysaccharide binding protein	Homo sapiens	0-40
7907325-6	1994	The hydrophobic amino acids Ile, Phe, Val, Leu, and Trp present the strongest interaction with GroEL.	Isoleucine	28-31	GroEL	Escherichia coli	95-100
8106503-14	1994	These results indicate that the carboxyl-terminal amino acid sequence, including the Leu-Ile motif and the sequence that connects the motif to the transmembrane domain, is critical for the sorting of Limp II to lysosomes.	Isoleucine	89-92	scavenger receptor class B member 2	Homo sapiens	200-207
8026990-7	1994	A comparison of amino acid sequences of HLA-A10 cross-reacting antigens revealed that all of the A10 group antigens share specific amino acids: 142 isoleucine, 144 glutamine, 145 arginine, 149 threonine, and 152 glutamate.	Isoleucine	148-158	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	97-100
8202463-4	1994	The water molecule present in the active site close to the copper ion in wild type (WT) SOD is missing in the MD average structure of the Thr-137-->Ile mutant, while this molecule is present in the MD average structures of all the other mutants and of WT SOD.	Isoleucine	151-154	superoxide dismutase 1	Homo sapiens	88-91
8202463-4	1994	The water molecule present in the active site close to the copper ion in wild type (WT) SOD is missing in the MD average structure of the Thr-137-->Ile mutant, while this molecule is present in the MD average structures of all the other mutants and of WT SOD.	Isoleucine	151-154	superoxide dismutase 1	Homo sapiens	258-261
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Isoleucine	52-55	eukaryotic translation elongation factor 2	Rattus norvegicus	148-167
8192856-4	1994	The sequence obtained for PHAPI revealed a novel primary structure with a leucine/isoleucine rich N-terminal region.	Isoleucine	82-92	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	26-31
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Isoleucine	52-55	eukaryotic translation elongation factor 2	Rattus norvegicus	169-173
8119297-3	1994	Correspondingly, the mutated ETA receptor with the Lys140-->Ile substitution failed to induce an increase in the intracellular calcium concentration in the presence of 1 nM ET-1.	Isoleucine	63-66	endothelin receptor type A	Homo sapiens	29-32
8278402-4	1994	Mutant p53 fusion proteins carrying amino acid substitutions Glu-213, Ile-237, or Tyr-238, derived from mutant p53 genes of Burkitt lymphomas, failed to catalyze these reactions.	Isoleucine	70-73	tumor protein p53	Homo sapiens	7-10
8019560-0	1994	A double-variant transthyretin allele (Ser 6, Ile 33) in the Israeli patient "SKO" with familial amyloidotic polyneuropathy.	Isoleucine	46-49	transthyretin	Homo sapiens	17-30
8188635-10	1994	Lundgard and Svensson pointed out that 23 amino acid residues of the peptide fragment derived from the COOH-terminal region of barley (cultivar Gula) beta-amylase were in agreement with the deduced amino acid sequence reported by Kreis et al., with the exception of a single position (Met-527 compared to Ile) [Carlsberg Res.	Isoleucine	305-308	1,4-alpha-D-glucan maltohydrolase	Hordeum vulgare	150-162
8113739-6	1994	Such aberrant replication of the PA gene was found to be attributable to an amino acid change in the NS2 protein at position 32, from isoleucine to threonine.	Isoleucine	134-144	NS2	Homo sapiens	101-104
7984499-5	1994	Rabbit PYY differs from porcine PYY, which is identical to rat and canine PYY, by two amino acid substitutions at positions 3 (Ser instead of Ala) and 18 (Asp instead of Ser), whereas rabbit PYY and human PYY differ by only one residue at position 3 (Ser instead of Ile).	Isoleucine	266-269	peptide YY	Oryctolagus cuniculus	7-10
8172556-18	1993	In order to control the autoactivation process point mutant cDNAs were constructed through altering the Arg-Ile bond in the catalytic domain of the C1r.	Isoleucine	108-111	complement C1r	Homo sapiens	148-151
8111231-6	1993	Overall structures with the lowest target penalty function were similar between the two forms, having a beta-turn structure at the endocyclic residues of the Tyr-Ile-Gln-Asn moiety.	Isoleucine	162-165	amyloid beta precursor protein	Homo sapiens	102-108
8142001-9	1993	Isoleucine residues in apo A-1 are inversely correlated to the homology of human to other species, except dog.	Isoleucine	0-10	apolipoprotein A1	Homo sapiens	23-30
8283388-0	1993	Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal.	Isoleucine	91-101	N-acetyltransferase 1	Rattus norvegicus	117-136
8411726-1	1993	Recently, three different mutations have been found at codon 717 of the amyloid precursor protein (APP) gene, changing the native valine to isoleucine, phenylalanine and glycine in some familial Alzheimer"s disease (FAD) kindreds.	Isoleucine	140-150	amyloid beta precursor protein	Homo sapiens	72-97
8401225-6	1993	Mutants that contained the single residue substitutions Ile-6-->Gly or Tyr-13-->Gly were reduced in potency to 4-30% compared with wild-type rC5a.	Isoleucine	56-59	complement C5	Rattus norvegicus	147-151
8401225-8	1993	The double mutant, Ile-6-->Gly/Tyr-13-->Gly, was reduced in potency to < 0.2%, which correlated with a correspondingly low binding affinity for neutrophil C5a receptors.	Isoleucine	19-22	complement C5a receptor 1	Homo sapiens	164-167
8349703-6	1993	This Phe343-->Ile mutant CYP17 did not exhibit changes either in delta 5-supported lyase activity or in delta 4- and delta 5-hydroxylase activities.	Isoleucine	17-20	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	28-33
8349703-9	1993	Unlike the bovine CYP17-catalyzed reaction, the rat Phe343-->Ile mutant exhibited a low level lyase activity (kcat) that did not discriminate between delta 4- and delta 5-substrates.	Isoleucine	64-67	steroid 17-alpha-hydroxylase/17,20 lyase	Bos taurus	18-23
8372815-1	1993	In beta zero-thalassemia and sickle cell patients, a 4 bp deletion at -222 to -225 of the A gamma globin promoter was associated with low expression of the A gamma T variant (threonine at codon 75 of A gamma), whereas A gamma I (isoleucine at 75) had the normal A gamma promoter and higher expression.	Isoleucine	229-239	hemoglobin subunit gamma 1	Homo sapiens	90-104
7866721-16	1994	In order to control the autoactivation process point mutant cDNAs were constructed by altering the Arg-Ile bond in the catalytic domain of the C1r.	Isoleucine	103-106	complement C1r	Homo sapiens	143-146
8287638-5	1993	In the present study an antiserum was raised to the C-terminal sequence of apolipoprotein B-48, using specific chemical reactions to ensure that the charged carboxyl group of the C-terminal isoleucine residue was free.	Isoleucine	190-200	apolipoprotein B	Homo sapiens	75-94
8339246-1	1993	The Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from the laminin B1 chain has been shown to decrease tumor growth and metastasis.	Isoleucine	8-11	laminin B1	Mus musculus	57-73
8244418-6	1993	Both MAbs retained about 55% reactivity with the ET-1 terminal sequence of Asp-Ile-Ile-Trp (ET18-21) but had no reactivity with the ET sequence His-Leu-Asp-Ile-Ile-Trp-Val-Asn (ET16-23) nor with Big ET-1 (ET1-39).	Isoleucine	79-82	endothelin 1	Homo sapiens	49-53
8244418-6	1993	Both MAbs retained about 55% reactivity with the ET-1 terminal sequence of Asp-Ile-Ile-Trp (ET18-21) but had no reactivity with the ET sequence His-Leu-Asp-Ile-Ile-Trp-Val-Asn (ET16-23) nor with Big ET-1 (ET1-39).	Isoleucine	83-86	endothelin 1	Homo sapiens	49-53
8409768-12	1993	Cloning and sequencing of apoB cDNA from dog liver and intestine confirmed additional C/U editing at C6655 which changes ACA for threonine at amino acid residue 2149 into AUA for isoleucine.	Isoleucine	179-189	apolipoprotein B	Canis lupus familiaris	26-30
7688477-4	1993	Affected members of two unrelated families with Weber-Cockayne EBS had a T-->G point mutation in the second base position of codon 161 of one of two K5 alleles, leading to an Ile-->Ser mutation.	Isoleucine	175-178	keratin 5	Homo sapiens	149-151
7688477-7	1993	Conserved among type II keratins, Ile-161 is in the nonhelical head domain of K5, a region previously shown to be important for 10-nm filament assembly.	Isoleucine	34-37	keratin 5	Homo sapiens	78-80
7687570-3	1993	The missense mutation at codon 294 (Ile-->Thr), which is located in the ATP-binding domain of the c-src, resulted in dramatic reduction of tyrosine kinase activity of the fusion protein.	Isoleucine	36-39	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-106
8497069-2	1993	This highly conserved zipper motif, which consists of a heptad repeat of leucine or isoleucine residues, has been suggested to play a role in HIV-1 env glycoprotein oligomerization.	Isoleucine	84-94	endogenous retrovirus group K member 20	Homo sapiens	148-151
8338834-12	1993	In our comparison of wild-type and (G12D) GDP-p21ras, we find that the resonance of Ile 36 is not visible in (G12D)p21ras.	Isoleucine	84-87	HRas proto-oncogene, GTPase	Homo sapiens	46-52
8338834-13	1993	In (G12D)p21ras, replacement of GDP by GTP gamma S causes the resonances of glycines 10, 13, 15, 60, and 75 and isoleucine 21 and four others to shift from their GDP-specific positions.	Isoleucine	112-122	HRas proto-oncogene, GTPase	Homo sapiens	9-15
8409432-7	1993	Finally, bulk sequencing profiles contained signals from further putative anchor residues clustering in the NH2-terminal region:tyrosine, phenylalanine, leucine, isoleucine, and valine are enriched at positions 2 to 4 in DR1, DR5, and DR6, however, at positions 4 to 6 in DR3.	Isoleucine	162-172	down-regulator of transcription 1	Homo sapiens	221-224
7683646-7	1993	Substitution of residues 48-50 with the analogous residues from human insulin (Thr-Ser-Ile) reduced binding to IGFBP-1, -5, and -6 more than 50-fold and to IGFBP-4 by 15-50-fold; binding to IGFBP-2 and -3 was reduced 6-12-fold.	Isoleucine	87-90	insulin	Homo sapiens	70-77
8490029-4	1993	Incorporation of [3H]Ile into PTHRP in cell extracts increased over 20 min during pulse labeling and then remained constant throughout the incubation period up to 6 h. In contrast, the release of [3H]PTHRP into culture medium increased progressively over 6 h. Addition of cycloheximide or unlabeled Ile almost completely blocked incorporation of [3H]Ile into newly synthesised PTHRP.	Isoleucine	21-24	parathyroid hormone-like hormone	Rattus norvegicus	30-35
8490029-4	1993	Incorporation of [3H]Ile into PTHRP in cell extracts increased over 20 min during pulse labeling and then remained constant throughout the incubation period up to 6 h. In contrast, the release of [3H]PTHRP into culture medium increased progressively over 6 h. Addition of cycloheximide or unlabeled Ile almost completely blocked incorporation of [3H]Ile into newly synthesised PTHRP.	Isoleucine	21-24	parathyroid hormone-like hormone	Rattus norvegicus	200-205
7683646-7	1993	Substitution of residues 48-50 with the analogous residues from human insulin (Thr-Ser-Ile) reduced binding to IGFBP-1, -5, and -6 more than 50-fold and to IGFBP-4 by 15-50-fold; binding to IGFBP-2 and -3 was reduced 6-12-fold.	Isoleucine	87-90	insulin like growth factor binding protein 1	Homo sapiens	111-130
8490029-4	1993	Incorporation of [3H]Ile into PTHRP in cell extracts increased over 20 min during pulse labeling and then remained constant throughout the incubation period up to 6 h. In contrast, the release of [3H]PTHRP into culture medium increased progressively over 6 h. Addition of cycloheximide or unlabeled Ile almost completely blocked incorporation of [3H]Ile into newly synthesised PTHRP.	Isoleucine	21-24	parathyroid hormone-like hormone	Rattus norvegicus	200-205
8490029-4	1993	Incorporation of [3H]Ile into PTHRP in cell extracts increased over 20 min during pulse labeling and then remained constant throughout the incubation period up to 6 h. In contrast, the release of [3H]PTHRP into culture medium increased progressively over 6 h. Addition of cycloheximide or unlabeled Ile almost completely blocked incorporation of [3H]Ile into newly synthesised PTHRP.	Isoleucine	299-302	parathyroid hormone-like hormone	Rattus norvegicus	200-205
7683646-7	1993	Substitution of residues 48-50 with the analogous residues from human insulin (Thr-Ser-Ile) reduced binding to IGFBP-1, -5, and -6 more than 50-fold and to IGFBP-4 by 15-50-fold; binding to IGFBP-2 and -3 was reduced 6-12-fold.	Isoleucine	87-90	insulin like growth factor binding protein 4	Homo sapiens	156-163
8490029-4	1993	Incorporation of [3H]Ile into PTHRP in cell extracts increased over 20 min during pulse labeling and then remained constant throughout the incubation period up to 6 h. In contrast, the release of [3H]PTHRP into culture medium increased progressively over 6 h. Addition of cycloheximide or unlabeled Ile almost completely blocked incorporation of [3H]Ile into newly synthesised PTHRP.	Isoleucine	299-302	parathyroid hormone-like hormone	Rattus norvegicus	200-205
7683646-7	1993	Substitution of residues 48-50 with the analogous residues from human insulin (Thr-Ser-Ile) reduced binding to IGFBP-1, -5, and -6 more than 50-fold and to IGFBP-4 by 15-50-fold; binding to IGFBP-2 and -3 was reduced 6-12-fold.	Isoleucine	87-90	insulin like growth factor binding protein 2	Homo sapiens	190-204
8512070-2	1993	The substrate, DABCYL-gaba-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS, has been designed to incorporate the renin cleavage site that occurs in the N-terminal peptide of human angiotensinogen.	Isoleucine	27-30	renin	Homo sapiens	111-116
7686694-6	1993	We have thus refined the localization of an HPA-3a determinant within the last 29 amino acids, including Ile843, of GPIIb heavy chain, and shown that the Lek(a) HPA-3a determinant is dependent, in part, upon the serine-linked carbohydrates adjacent to Ile/Ser843.	Isoleucine	105-108	integrin subunit alpha 2b	Homo sapiens	116-121
8486380-0	1993	The loss of a polymorphic glycosylation site caused by Thr-927-->Ile is linked to a second polymorphic Val-816-->Ile substitution in lysosomal alpha-glucosidase of American blacks.	Isoleucine	68-71	alpha glucosidase	Homo sapiens	139-166
8463322-0	1993	Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin.	Isoleucine	43-46	actinin alpha 1	Homo sapiens	154-167
8463322-0	1993	Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin.	Isoleucine	43-46	vinculin	Homo sapiens	172-180
8461309-0	1993	How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27-->serine mutation in Escherichia coli dihydrofolate reductase?	Isoleucine	42-52	Dihydrofolate reductase	Escherichia coli	149-172
8473344-4	1993	In fact, point mutation of the P1" site from Ser (present in AT-III) to Ile (present in prothrombin) is sufficient to dissociate heparin-dependent thrombin and Factor Xa inhibitory activities.	Isoleucine	72-75	serpin family C member 1	Homo sapiens	61-67
8473344-4	1993	In fact, point mutation of the P1" site from Ser (present in AT-III) to Ile (present in prothrombin) is sufficient to dissociate heparin-dependent thrombin and Factor Xa inhibitory activities.	Isoleucine	72-75	coagulation factor II, thrombin	Homo sapiens	91-99
8473344-4	1993	In fact, point mutation of the P1" site from Ser (present in AT-III) to Ile (present in prothrombin) is sufficient to dissociate heparin-dependent thrombin and Factor Xa inhibitory activities.	Isoleucine	72-75	coagulation factor X	Homo sapiens	160-169
8486380-0	1993	The loss of a polymorphic glycosylation site caused by Thr-927-->Ile is linked to a second polymorphic Val-816-->Ile substitution in lysosomal alpha-glucosidase of American blacks.	Isoleucine	119-122	alpha glucosidase	Homo sapiens	139-166
8429314-0	1993	Absence of the amyloid precursor protein gene mutation (APP717: Val->Ile) in 85 cases of early onset Alzheimer"s disease.	Isoleucine	69-72	amyloid beta precursor protein	Homo sapiens	15-40
8461023-3	1993	The codon 180 variant PrP (valine to isoleucine) was found in Creutzfeldt-Jakob disease (CJD) patients with a similar clinical course to that of codon 178 mutation.	Isoleucine	37-47	prion protein	Homo sapiens	22-25
8381415-8	1993	In EGF5-EGF6, critical residues within a proposed acidic thrombin-binding region were: Glu-408, Tyr-413, Ile-414, Leu-415, Asp-416, Asp-417, Asp-423, Ile-424, Asp-425, and Glu-426.	Isoleucine	105-108	coagulation factor II, thrombin	Homo sapiens	57-65
8381415-8	1993	In EGF5-EGF6, critical residues within a proposed acidic thrombin-binding region were: Glu-408, Tyr-413, Ile-414, Leu-415, Asp-416, Asp-417, Asp-423, Ile-424, Asp-425, and Glu-426.	Isoleucine	150-153	coagulation factor II, thrombin	Homo sapiens	57-65
7683786-4	1993	In both CHM and Kv2.1, channels with the substituted hydrophobic residues Val or Ile expressed Rb(+)-preferring pores while channels with the substituted polar residues Thr or Ser expressed K(+)-preferring pores.	Isoleucine	81-84	potassium channel, voltage gated Shab related subfamily B, member 1 S homeolog	Xenopus laevis	16-21
8510196-7	1993	The levels of serine, isoleucine and phenylalanine in the CSF within 6 hours after convulsion were significantly lower than the normal control; while asparagine, tyrosine, lysine and arginine were significantly higher.	Isoleucine	22-32	colony stimulating factor 2	Homo sapiens	58-61
7681676-3	1993	Further analysis of cloned GluR6 cDNA revealed that two additional positions, located in transmembrane segment TM1, are diversified by RNA editing to generate either isoleucine (I) or valine (V) in one and tyrosine (Y) or cysteine (C) in the other TM1 position.	Isoleucine	166-176	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	27-32
8443603-4	1993	The synthetic peptide Lys-Pro-Ile-Glu-Phe*Nph-Arg-Leu has proven to be an excellent chromogenic substrate for cathepsin D yielding a value of kcat/Km = 0.92 x 10(-6) s-1 M-1 for enzyme isolated from human placenta.	Isoleucine	30-33	cathepsin D	Homo sapiens	110-121
8443603-6	1993	To explore the binding requirements of the S3 and S2 subsites of cathepsin D, a series of synthetic peptides was prepared with systematic replacements at the P2 position fixing either Ile or Ala in P3.	Isoleucine	184-187	cathepsin D	Homo sapiens	65-76
1328674-5	1992	Sites of protease cleavage were identified in the deduced amino acid sequence of mu 1 by determining the amino-terminal sequences of phi proteins: trypsin cleaves between arginine 584 and isoleucine 585, and chymotrypsin cleaves between tyrosine 581 and glycine 582.	Isoleucine	188-198	glutathione S-transferase mu 1	Homo sapiens	81-85
8387235-4	1993	By inspection of the three-dimensional structure of the portion of the PPAR ligand-binding domain, a putative binding site for peroxisome proliferators, consisting of one isoleucine, one lysine and two phenylalanine moieties (residues 354, 358, 359 and 361, respectively), has been identified.	Isoleucine	171-181	peroxisome proliferator activated receptor alpha	Mus musculus	71-75
1448083-1	1992	The ILV1 gene of Saccharomyces cerevisiae encodes the first committed step in isoleucine biosynthesis and is regulated by general control of amino acid biosynthesis.	Isoleucine	78-88	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	4-8
1420172-5	1992	We now report the importance of these two residues in the structure and function of PLA2 in terms of aromaticity (changing to Ile) and hydrophobic (changing to Ala) and hydrophilic (changing to Tyr) character of these residues.	Isoleucine	126-129	LOC104974671	Bos taurus	84-88
1443599-1	1992	The angiotensin I-based peptide Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Glu-Glu-Ser yields angiotensin I (Ang I) and Leu-Glu-Glu-Ser upon hydrolysis by the human immunodeficiency virus type 1 (HIV-1) protease, but not by human renin.	Isoleucine	48-51	renin	Homo sapiens	231-236
1465214-2	1992	There was abundant PHF-tau present, which on Western blots, was indistinguishable from the PHF-tau typical of cases of sporadic Alzheimer"s disease and that of another FAD mutation (valine to isoleucine), previously (Neurosci.	Isoleucine	192-202	microtubule associated protein tau	Homo sapiens	19-26
1398122-8	1992	The CDC60 gene product also shows homology to LeuRSs from other organisms and to aminoacyl-RS for isoleucine, valine and methionine.	Isoleucine	98-108	leucine--tRNA ligase CDC60	Saccharomyces cerevisiae S288C	4-9
1306119-8	1992	The corresponding NAT2 proteins differ by a single change at amino acid 99: an hydrophilic asparagine in rapid acetylator NAT2 to an hydrophobic isoleucine in NAT2 from slow acetylators.	Isoleucine	145-155	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	18-22
1439759-6	1992	Binding activity was found to occur within a 26-amino acid sequence of Ig-alpha and Ig-beta that contains a motif [(Asp or Glu)-(any amino acid)7-(Asp or Glu)-Tyr-(any amino acid)3-Leu-(any amino acid)7-Tyr-(any amino acid)2-(Leu or Ile)] previously implicated in signal transduction via other receptors including the Fc epsilon receptor I and the T cell antigen receptor.	Isoleucine	233-236	CD79a molecule	Homo sapiens	71-79
1439759-6	1992	Binding activity was found to occur within a 26-amino acid sequence of Ig-alpha and Ig-beta that contains a motif [(Asp or Glu)-(any amino acid)7-(Asp or Glu)-Tyr-(any amino acid)3-Leu-(any amino acid)7-Tyr-(any amino acid)2-(Leu or Ile)] previously implicated in signal transduction via other receptors including the Fc epsilon receptor I and the T cell antigen receptor.	Isoleucine	233-236	CD79b molecule	Homo sapiens	84-91
1306119-8	1992	The corresponding NAT2 proteins differ by a single change at amino acid 99: an hydrophilic asparagine in rapid acetylator NAT2 to an hydrophobic isoleucine in NAT2 from slow acetylators.	Isoleucine	145-155	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	122-126
1306119-8	1992	The corresponding NAT2 proteins differ by a single change at amino acid 99: an hydrophilic asparagine in rapid acetylator NAT2 to an hydrophobic isoleucine in NAT2 from slow acetylators.	Isoleucine	145-155	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	122-126
1530638-3	1992	The binding mode of n-C12PC to the PLA2 was clearly indicated, where the dodecyl chain was stably held by the hydrophobic contacts with the N-terminal region of PLA2 (Leu-2, Phe-5, and Ile-9), and the choline moiety was contacted with the hydrophobic space created by the side chains of Lys-53 and 56.	Isoleucine	185-188	LOC104974671	Bos taurus	35-39
1466808-3	1992	Using conformational energy analysis based on ECEPP (Empirical Conformational Energies for Polypeptides Program), we have determined the preferred three dimensional structures for this tridecapeptide sequence for the human wild-type p53 protein and four cancer-related mutant p53 proteins (Ala 245, Ile 246, Trp 248, Ser 249).	Isoleucine	299-302	tumor protein p53	Homo sapiens	233-236
1358789-6	1992	Three children had inherited a G-to-A transition at codon 415 in exon 12 of the PAH gene, resulting in the substitution of asparagine for aspartate, whereas one child possessed an A-to-G transition at codon 306 in exon 9, causing the replacement of an isoleucine by a valine in the enzyme.	Isoleucine	252-262	phenylalanine hydroxylase	Homo sapiens	80-83
1466808-3	1992	Using conformational energy analysis based on ECEPP (Empirical Conformational Energies for Polypeptides Program), we have determined the preferred three dimensional structures for this tridecapeptide sequence for the human wild-type p53 protein and four cancer-related mutant p53 proteins (Ala 245, Ile 246, Trp 248, Ser 249).	Isoleucine	299-302	tumor protein p53	Homo sapiens	276-279
1352515-3	1992	The inhibition of biosynthesis of homoserine by the antibiotic was attributable to inactivation of homoserine dehydrogenase [EC 1.1.1.3], which is involved in the conversion of aspartate semialdehyde to homoserine in the metabolic pathway leading to threonine, methionine and isoleucine.	Isoleucine	276-286	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	99-123
1517593-4	1992	Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.	Isoleucine	123-126	LOC105243590	Mus musculus	79-83
16669005-1	1992	Acetohydroxyacid synthase (AHAS), the first enzyme unique to the biosynthesis of isoleucine, leucine, and valine, is the target enzyme for several classes of herbicides.	Isoleucine	81-91	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	27-31
1599944-3	1992	When apo-TnC is titrated with mastoparan, line-broadening is observed for the ring-current shifted resonance of Phe-23, Ile-34, Val-62 and Phe-72 and the downfield-shifted CH alpha-resonances of Asp-33, Thr-69 and Asp-71; these residues are located in the N-domain.	Isoleucine	120-123	tenascin	Oryctolagus cuniculus	9-12
1524216-3	1992	The hydrolysis of Abz-His-Pro-Phe-His-Leu-Val-Ile-His-EDDnp by human renin was inhibited by a highly specific transition-state analog of angiotensinogen (IC50 = 7.8 x 10(-9) M), described by K. Iizuka et al.	Isoleucine	46-49	renin	Homo sapiens	69-74
1524216-3	1992	The hydrolysis of Abz-His-Pro-Phe-His-Leu-Val-Ile-His-EDDnp by human renin was inhibited by a highly specific transition-state analog of angiotensinogen (IC50 = 7.8 x 10(-9) M), described by K. Iizuka et al.	Isoleucine	46-49	angiotensinogen	Homo sapiens	137-152
1510947-6	1992	Edman degradation of the two labeled peptides showed a single sequence His-Pro-Ile-([3H]X)-Arg corresponding to the pentapeptide His-Pro-Ile-Met-Arg 136-140 of SHBG sequence.	Isoleucine	79-82	sex hormone binding globulin	Homo sapiens	160-164
1508225-6	1992	Substitution of the Asn residue in either consensus sequence for Asn-linked glycosylation with an Ile residue resulted in increased mobility of the immunoreactive ABP species.	Isoleucine	98-101	sex hormone binding globulin	Rattus norvegicus	163-166
1618766-4	1992	On the basis of these results, replacement of Leu29(B10) by Ala or Ile appears to allow bound CO to rotate from a conformation pointing toward the beta meso carbon of the heme group to the one pointing toward the alpha meso carbon atom, presumably filling the space left by removal of the delta 2 carbon atom of Leu29(B10).	Isoleucine	67-70	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	46-55
1618766-4	1992	On the basis of these results, replacement of Leu29(B10) by Ala or Ile appears to allow bound CO to rotate from a conformation pointing toward the beta meso carbon of the heme group to the one pointing toward the alpha meso carbon atom, presumably filling the space left by removal of the delta 2 carbon atom of Leu29(B10).	Isoleucine	67-70	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	52-55
1607069-5	1992	Glucose uptake by forearm tissues in response to GH and insulin did not change significantly between 3 and 6 h. By 6 h, the combined infusion of GH and insulin promoted a significantly more positive net balance of phenylalanine, leucine, isoleucine, and valine (all P less than 0.05).	Isoleucine	238-248	growth hormone 1	Homo sapiens	145-147
1607069-5	1992	Glucose uptake by forearm tissues in response to GH and insulin did not change significantly between 3 and 6 h. By 6 h, the combined infusion of GH and insulin promoted a significantly more positive net balance of phenylalanine, leucine, isoleucine, and valine (all P less than 0.05).	Isoleucine	238-248	insulin	Homo sapiens	152-159
1547237-6	1992	The global folding of these conformations is similar to that in the thrombin-bound state, as indicated by NOE"s involving the side-chain protons of residues Phe(56), Ile(59), Pro(60), Tyr(63), and Leu(64).	Isoleucine	166-169	coagulation factor II, thrombin	Homo sapiens	68-76
1312344-9	1992	We conclude that properties of arginine valine, isoleucine, and phenylalanine side chains within an RGVHFIF-containing domain of gp91-phox contribute significantly to cytochrome b558-mediated activation of the oxidase.	Isoleucine	48-58	mitochondrially encoded cytochrome b	Homo sapiens	167-179
1547237-9	1992	An analysis of the side-chain rotamers revealed that, upon binding to thrombin, there may be a rotation around the alpha CH-beta CH bond of Ile(59) such that Ile(59) adopts a gauche- (chi 1 = +60) conformation in contrast to the highly populated trans (chi 1 = -60) found for Ile(59) in the free peptide.	Isoleucine	140-143	coagulation factor II, thrombin	Homo sapiens	70-78
1547237-9	1992	An analysis of the side-chain rotamers revealed that, upon binding to thrombin, there may be a rotation around the alpha CH-beta CH bond of Ile(59) such that Ile(59) adopts a gauche- (chi 1 = +60) conformation in contrast to the highly populated trans (chi 1 = -60) found for Ile(59) in the free peptide.	Isoleucine	158-161	coagulation factor II, thrombin	Homo sapiens	70-78
1547237-9	1992	An analysis of the side-chain rotamers revealed that, upon binding to thrombin, there may be a rotation around the alpha CH-beta CH bond of Ile(59) such that Ile(59) adopts a gauche- (chi 1 = +60) conformation in contrast to the highly populated trans (chi 1 = -60) found for Ile(59) in the free peptide.	Isoleucine	158-161	coagulation factor II, thrombin	Homo sapiens	70-78
1547237-11	1992	The apparent preference for a gauche- (chi 1 = +60) side-chain conformation of Ile(59) in the bound state may be explained by the existence of a positively charged arginine residue among the hydrophobic residues in the thrombin exosite.	Isoleucine	79-82	coagulation factor II, thrombin	Homo sapiens	219-227
1301201-3	1992	Here we report (1) identification of another mutation, on a haplotype 9 chromosome, which converts codon 65 from isoleucine (ATT) to threonine (ACT), (2) expression analysis of the I65T mutation in COS cells demonstrating 75% loss of both immunoreactive protein and enzyme activity, and (3) expression analysis of the most prevalent PKU allele (M1V) in eastern Quebec, showing nondetectable levels of PAH protein and activity, a finding compatible with a mutation in the translation initiation codon.	Isoleucine	113-123	phenylalanine hydroxylase	Homo sapiens	401-404
1311955-3	1992	Similar to its ligands, the amino acid sequence of the activin receptor is highly conserved with only two conservative amino acid differences (Lys-39 and Val-92 in human versus Arg-39 and Ile-92 in the mouse).	Isoleucine	188-191	inhibin subunit beta E	Homo sapiens	55-62
1551445-3	1992	In contrast, GTP hydrolysis by Ile-41 rhoA or Ha-ras, which are no substrates for the transferase, were not affected by C3.	Isoleucine	31-34	ras homolog family member A	Homo sapiens	38-42
1661670-3	1991	Two such PDGF-B chain residues, arginine 27 and isoleucine 30, have been identified by a site-directed mutagenesis programme.	Isoleucine	48-58	platelet derived growth factor subunit B	Homo sapiens	9-21
1729197-5	1992	Three such mutant alleles encoded Thr-to-Ile substitutions at residues 13, 14, and 34 in the mature B polypeptide of LT-IIa.	Isoleucine	41-44	colicin Ia immunity protein	Escherichia coli	120-123
1728720-9	1992	The net myocardial uptake of leucine and isoleucine shifted to a no-uptake/no-release in the insulin-treated group, whereas the no-uptake/no-release of tyrosine and phenylalanine turned into a significant release.	Isoleucine	41-51	insulin	Homo sapiens	93-100
1728720-11	1992	It is suggested that insulin, by lowering the arterial concentration of leucine and isoleucine, inhibited the myocardial uptake of these amino acids.	Isoleucine	84-94	insulin	Homo sapiens	21-28
1955126-1	1991	The absence of isoleucine in the hemoglobin molecule has been suggested to contribute to increased urea production after a blood meal.	Isoleucine	15-25	HGB	Sus scrofa	33-43
1480089-3	1992	We have thus utilized this approach to alter the Col1a1 gene to encode amino acid substitutions in sequences around the known collagenase cleavage site (glycine-isoleucine at positions 775-776) in type I collagen, and transfect these genes into homozygous Mov-13 fibroblasts, in which the endogenous Col1a1 gene is inactive.	Isoleucine	161-171	collagen, type I, alpha 1	Mus musculus	49-55
1729723-2	1992	This enzyme, which has an apparent molecular mass of 100 kDa, performs a selective cleavage at the Xaa-Phe, Xaa-Leu, or Xaa-Ile bond (Xaa = Ser, Phe, Tyr, His, or Gly) of a number of peptide hormones, including atrial natriuretic factor, substance P, angiotensin II, bradykinin, somatostatin, neuromedins B and C, and litorin.	Isoleucine	124-127	tachykinin precursor 1 S homeolog	Xenopus laevis	238-249
1729723-2	1992	This enzyme, which has an apparent molecular mass of 100 kDa, performs a selective cleavage at the Xaa-Phe, Xaa-Leu, or Xaa-Ile bond (Xaa = Ser, Phe, Tyr, His, or Gly) of a number of peptide hormones, including atrial natriuretic factor, substance P, angiotensin II, bradykinin, somatostatin, neuromedins B and C, and litorin.	Isoleucine	124-127	bradykinin receptor B2 S homeolog	Xenopus laevis	267-277
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Isoleucine	47-50	interleukin 1 beta	Homo sapiens	106-115
1744032-6	1991	Genes ilvC and ilv5 code for the enzyme acetohydroxy acid isomeroreductase (isomeroreductase), the second enzyme in the parallel pathways for the biosynthesis of isoleucine and valine.	Isoleucine	162-172	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	15-19
16668488-1	1991	Acetolactate synthase (ALS), the first enzyme in the biosynthetic pathway of leucine, isoleucine, and valine, is inhibited by imidazolinone herbicides.	Isoleucine	86-96	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	23-26
1718750-2	1991	One peptide, His-Gly-Arg-Val-Gly-Ile-Tyr-Phe-Gly-Met-Lys (peptide 11; Ile, isoleucine) is antigenic and binds with a high affinity to a monoclonal antibody that recognizes the native beta 2 subunit.	Isoleucine	33-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	183-189
1718750-2	1991	One peptide, His-Gly-Arg-Val-Gly-Ile-Tyr-Phe-Gly-Met-Lys (peptide 11; Ile, isoleucine) is antigenic and binds with a high affinity to a monoclonal antibody that recognizes the native beta 2 subunit.	Isoleucine	70-73	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	183-189
1718750-2	1991	One peptide, His-Gly-Arg-Val-Gly-Ile-Tyr-Phe-Gly-Met-Lys (peptide 11; Ile, isoleucine) is antigenic and binds with a high affinity to a monoclonal antibody that recognizes the native beta 2 subunit.	Isoleucine	75-85	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	183-189
1665486-6	1991	5) Preincubation of the rat liver supernatant with an antibody against Artemia salina ribosomal protein L5, that cross-reacted with the rat liver ribosomal protein L5, decreased the attachment of [35S]methionine and [3H]isoleucine to endogenous tRNA, and 5SrRNA and 5SRNP enhanced these activities of the supernatant preincubated with antibody.	Isoleucine	220-230	ribosomal protein L5	Rattus norvegicus	86-106
1665486-6	1991	5) Preincubation of the rat liver supernatant with an antibody against Artemia salina ribosomal protein L5, that cross-reacted with the rat liver ribosomal protein L5, decreased the attachment of [35S]methionine and [3H]isoleucine to endogenous tRNA, and 5SrRNA and 5SRNP enhanced these activities of the supernatant preincubated with antibody.	Isoleucine	220-230	ribosomal protein L5	Rattus norvegicus	146-166
1657158-1	1991	Twelve amino acid substitutions of varying size and hydrophobicity were constructed at Val 143 in human carbonic anhydrase II (including Gly, Ser, Cys, Asn, Asp, Leu, Ile, His, Phe and Tyr) to examine the catalytic roles of the hydrophobic pocket in the active site of this enzyme.	Isoleucine	167-170	carbonic anhydrase 2	Homo sapiens	104-125
1919003-2	1991	Comparison of amino acid sequences of the alpha-chain fragment of C4, C4d, has shown C4A- and C4B-specific sequences at residues 1101-1106 are the only consistent structural difference between isotype, i.e., Pro, Cys, Pro, Val, Leu, Asp in C4A and Leu, Ser, Pro, Val Ile, His in C4B.	Isoleucine	267-270	complement C4B (Chido blood group)	Homo sapiens	94-97
1937474-7	1991	The sequence of three independent clones originating from the defective P450c21B showed that Ile at position 172 in exon 4 was substituted by Asn.	Isoleucine	93-96	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	72-80
1778986-1	1991	Three DNA constructs, pETB-40, 41, and 42, encoding human big endothelin-1 (ET-1) preceded by the specific recognition sequence (Ile-Glu-Gly-Arg) for the activated blood coagulation factor Xa (FXa), fused in frame to the N-terminal portion of beta Gal, were expressed in Escherichia coli.	Isoleucine	129-132	coagulation factor X	Homo sapiens	182-191
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Isoleucine	74-77	angiotensinogen	Homo sapiens	41-56
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Isoleucine	74-77	renin	Homo sapiens	302-307
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Isoleucine	102-105	angiotensinogen	Homo sapiens	41-56
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Isoleucine	102-105	renin	Homo sapiens	302-307
1918382-6	1991	Sequence analysis of the GLUT-4 gene revealed that one patient was heterozygous for a mutation in which isoleucine (ATC) was substituted for valine (GTC) at position 383.	Isoleucine	104-114	solute carrier family 2 member 4	Homo sapiens	25-31
16668449-1	1991	Acetohydroxyacid synthase (AHAS, EC 4.1.3.18) is the first enzyme unique to the biosynthesis of valine, leucine, and isoleucine.	Isoleucine	117-127	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	0-25
16668449-1	1991	Acetohydroxyacid synthase (AHAS, EC 4.1.3.18) is the first enzyme unique to the biosynthesis of valine, leucine, and isoleucine.	Isoleucine	117-127	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	27-31
1898367-5	1991	The protein sequence of G7a contains two short consensus sequences, His-Ile-Gly-His and Lys-Met-Ser-Lys-Ser, which is the typical signature structure of class I tRNA synthetases and indicative of the presence of the Rossman fold.	Isoleucine	72-75	valyl-tRNA synthetase 1	Homo sapiens	24-27
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Isoleucine	48-51	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	165-170
1859409-3	1991	Therefore, medullasin is composed of 238 amino acid residues with Ile as the amino terminal and His as the carboxyl terminal.	Isoleucine	66-69	elastase, neutrophil expressed	Homo sapiens	11-21
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Isoleucine	48-51	fibronectin 1	Mus musculus	153-155
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Isoleucine	150-153	phospholipase A2 activating protein	Homo sapiens	73-111
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Isoleucine	150-153	phospholipase A2 activating protein	Homo sapiens	113-117
1910042-2	1991	Eleven amino acid substitutions at Val-121 of human carbonic anhydrase II including Gly, Ala, Ser, Leu, Ile, Lys, and Arg, were constructed by site-directed mutagenesis.	Isoleucine	104-107	carbonic anhydrase 2	Homo sapiens	52-73
1831408-5	1991	Using cells synchronized at the G1/S border with excess thymidine or in early G1 using isoleucine-deficient media, IL-2 and IL-5 differed in their cell-cycle dependency for signal transmission.	Isoleucine	87-97	interleukin 2	Mus musculus	115-119
1831408-5	1991	Using cells synchronized at the G1/S border with excess thymidine or in early G1 using isoleucine-deficient media, IL-2 and IL-5 differed in their cell-cycle dependency for signal transmission.	Isoleucine	87-97	interleukin 5	Mus musculus	124-128
1713513-5	1991	Similarly, a Baka GPIIb cDNA expressing an isoleucine at amino acid 843 (IIe843) was modified to express the Bakb form containing a serine at the same position (Ser843).	Isoleucine	43-53	integrin subunit alpha 2b	Homo sapiens	18-23
1716913-1	1991	A metal binding peptide, hexahistidine, preceding a renin cleavage sequence (Pro-Phe-His-Leu-Val-Ile-His-) was engineered on to the N-terminus of HIV-1 reverse transcriptase (RT).	Isoleucine	97-100	renin	Homo sapiens	52-57
1646814-1	1991	We have determined the structures and thermodynamic stabilities of the wild type Asn-52 and unusually thermostable mutant Ile-52 yeast iso-1-cytochromes c (Das, G., Hickey, D. R. McLendon, D., McLendon, G., and Sherman, F. (1989) Proc.	Isoleucine	122-125	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	135-140
1645337-5	1991	A systematic analysis revealed that replacement of Asn-115, Arg-154, and Ile-158 of the PDGF B-chain with the corresponding A-chain amino acids led to a dramatic decrease in the affinity for the beta-receptor.	Isoleucine	73-76	platelet derived growth factor subunit B	Homo sapiens	88-94
1645337-7	1991	These data thus indicate that Asn-115, Arg-154, and Ile-158 are likely to be part of the active site of the PDGF B-chain.	Isoleucine	52-55	platelet derived growth factor subunit B	Homo sapiens	108-114
1674746-6	1991	Furthermore, mutation of Met-407, Ile-410, Leu-413, or Leu-414 to a hydrophilic residue eliminated CD4 endocytosis as did domain truncation at Arg-412.	Isoleucine	34-37	CD4 molecule	Homo sapiens	99-102
1674945-6	1991	Amplification of individual exons by the polymerase chain reaction and direct sequencing revealed a T----C transition at codon 194 of the LPL cDNA which results in a substitution of threonine for isoleucine at this residue.	Isoleucine	196-206	lipoprotein lipase	Homo sapiens	138-141
1717728-4	1991	(1981) Biochemistry 20:2361] that two residues, the serine and isoleucine specific for IgG3 subclass at position 422, cause the structural change responsible for b markers.	Isoleucine	63-73	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	87-91
1848998-3	1991	This chain was designed to form a 78-residue noncovalent dimer (P39) by folding the coils of two chains into an alpha-helical coiled coil through hydrophobic interaction of eight pairs of Ile residues.	Isoleucine	188-191	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	64-67
2019570-4	1991	During the activation, factor XI was cleaved at a single Arg-Ile bond by thrombin or factor XIa to produce an amino-terminal 50-kDa heavy chain and a carboxyl-terminal 35-kDa light chain.	Isoleucine	61-64	coagulation factor II, thrombin	Homo sapiens	73-81
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Isoleucine	235-238	prolactin receptor	Homo sapiens	89-102
2001710-1	1991	The histidine at position 55 of the amino acid sequence of the Escherichia coli single-stranded DNA binding protein was replaced by tyrosine, glutamic acid, lysine, phenylalanine, and isoleucine.	Isoleucine	184-194	single-stranded DNA-binding protein	Escherichia coli	80-115
1715993-6	1991	Galanin analogues where the 2nd N-terminal amino acid had been changed from tryptophan to tyrosine (GAL-TYR2) or isoleucine (GAL-ILE2) inhibited insulin secretion, as did porcine galanin1-29, whereas after substitution with phenylalanine (GAL-PHE2) no effect was observed.	Isoleucine	113-123	galanin and GMAP prepropeptide	Rattus norvegicus	125-133
1826081-11	1991	These results demonstrate that the high-affinity 67 kDa laminin receptor previously identified in a range of normal and transformed cells and its complementary Tyr-Ile-Gly-Ser-Arg binding domain play an important role in the interaction of platelets with laminin.	Isoleucine	164-167	ribosomal protein SA	Homo sapiens	49-72
1719770-4	1991	We conclude that the loss of an isoleucine residue at position 507 (Delta I507) is another defective variant of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene product.	Isoleucine	32-42	CF transmembrane conductance regulator	Homo sapiens	116-167
2214016-0	1990	Site-directed mutagenesis of the codon for Ile-25 in gPr80env alters the neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.	Isoleucine	43-46	Trichinella spiralis resistance 1	Mus musculus	91-94
2266553-2	1990	The aspartic proteinase, endothiapepsin (EC 3.4.23.6), was complexed with a highly potent renin inhibitor, H-261 (t-Boc-His-Pro-Phe-His-LeuOHVal-Ile-His), where OH denotes a hydroxyethylene (-(S) CHOH-CH2-) transition-state isostere in the scissile bond surrogate.	Isoleucine	145-148	renin	Homo sapiens	90-95
2246265-7	1990	Among 11 Xaa-Ala-Ser analogues (Xaa = Ala, Asp, Gln, Glu, Ile, Leu, Lys, Met, Phe, Pro, and Ser), MAP cleaved only Met-Ala-Ser.	Isoleucine	58-61	methionine aminopeptidase	Saccharomyces cerevisiae S288C	98-101
1719770-4	1991	We conclude that the loss of an isoleucine residue at position 507 (Delta I507) is another defective variant of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene product.	Isoleucine	32-42	CF transmembrane conductance regulator	Homo sapiens	169-173
1985460-5	1991	We have sequenced the rhodopsin gene in a C17-linked ADRP family and have identified in the 4th exon and in-frame 3-bp deletion which deletes one of the two isoleucine monomers at codons 255 and 256.	Isoleucine	157-167	rhodopsin	Homo sapiens	22-31
1985460-5	1991	We have sequenced the rhodopsin gene in a C17-linked ADRP family and have identified in the 4th exon and in-frame 3-bp deletion which deletes one of the two isoleucine monomers at codons 255 and 256.	Isoleucine	157-167	cytokine like 1	Homo sapiens	42-45
2170418-6	1990	These regions are located between amino acids Asn-230 and Ile-285 on the IR and between His-223 and Met-274 on the IGFIR.	Isoleucine	58-61	insulin receptor	Cricetulus griseus	73-75
2170418-6	1990	These regions are located between amino acids Asn-230 and Ile-285 on the IR and between His-223 and Met-274 on the IGFIR.	Isoleucine	58-61	insulin-like growth factor 1 receptor	Cricetulus griseus	115-120
1696474-1	1990	The synthetic phosphotyrosyl tridecapeptide H-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr(P)-Thr-Ala-Arg-Gln-Gly-OH, reproducing a major phosphoacceptor site of protein tyrosine kinases of the src-family, can be phosphorylated at Thr-9 by both casein kinases -1 and -2.	Isoleucine	54-57	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	181-184
2168396-7	1990	Tryptic digestion of cG-BPDE phosphorylated by cGK and [gamma-32P]ATP produced a single major phosphopeptide of approximately 2 kDa with the following amino-terminal sequence: Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg- Radioactivity was released during the third cycle of Edman degradation.	Isoleucine	180-183	phosphodiesterase 5A	Bos taurus	21-28
2148938-1	1990	The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-OEt is the analog of the S-site, one of the actin-binding sites in myosin [Suzuki et al.	Isoleucine	17-20	myosin heavy chain 14	Homo sapiens	112-118
2148938-10	1990	Based on these results, the side chains of Ile(702), Arg(703), and Cys(SH1)(705) in myosin subfragment-1 heavy chain were assigned to be critical for the binding with F-actin.	Isoleucine	43-46	myosin heavy chain 14	Homo sapiens	84-90
2395880-4	1990	The differences in covalent binding properties correlate only with amino acid changes between residues 1101 and 1106 (pro-C4 numbering)--namely, Pro-1101, Cys-1102, Leu-1105, and Asp-1106 in C4A and Leu-1101, Ser-1102, Ile-1105, and His-1106 in C4B, which are located in the C4d region of the alpha chain.	Isoleucine	219-222	complement C4A (Rodgers blood group)	Homo sapiens	191-194
2391767-6	1990	The effect of W-7 on calcium- and cadmium-saturated CaM was reflected in changes in the signals of Ile-27, Phe-68, Phe-92, Ile-100 and Val-142, as well as Met-71, Met-72, Met-76, Phe-89 and Phe-141.	Isoleucine	99-102	calmodulin	Bos taurus	52-55
2275749-1	1990	We have synthesized an insulin-like compound, consisting of the B-chain of bovine insulin and an A-chain corresponding to the A-domain of human insulin-like growth factor-I (IGF-I), in which the isoleucine residue normally present in position 2 of the A-domain of IGF-I has been replaced with glycine.	Isoleucine	195-205	insulin	Bos taurus	23-30
2275749-1	1990	We have synthesized an insulin-like compound, consisting of the B-chain of bovine insulin and an A-chain corresponding to the A-domain of human insulin-like growth factor-I (IGF-I), in which the isoleucine residue normally present in position 2 of the A-domain of IGF-I has been replaced with glycine.	Isoleucine	195-205	insulin like growth factor 1	Homo sapiens	144-172
2275749-1	1990	We have synthesized an insulin-like compound, consisting of the B-chain of bovine insulin and an A-chain corresponding to the A-domain of human insulin-like growth factor-I (IGF-I), in which the isoleucine residue normally present in position 2 of the A-domain of IGF-I has been replaced with glycine.	Isoleucine	195-205	insulin like growth factor 1	Homo sapiens	174-179
2275749-1	1990	We have synthesized an insulin-like compound, consisting of the B-chain of bovine insulin and an A-chain corresponding to the A-domain of human insulin-like growth factor-I (IGF-I), in which the isoleucine residue normally present in position 2 of the A-domain of IGF-I has been replaced with glycine.	Isoleucine	195-205	insulin like growth factor 1	Homo sapiens	264-269
2391767-6	1990	The effect of W-7 on calcium- and cadmium-saturated CaM was reflected in changes in the signals of Ile-27, Phe-68, Phe-92, Ile-100 and Val-142, as well as Met-71, Met-72, Met-76, Phe-89 and Phe-141.	Isoleucine	123-126	calmodulin	Bos taurus	52-55
1969228-7	1990	The presence of a codon for isoleucine at the residues corresponding to codon 255 of rat CPA1 cDNA strongly suggests that the A form of human carboxypeptidase has been isolated.	Isoleucine	28-38	carboxypeptidase A1	Rattus norvegicus	89-93
2350549-8	1990	Distance geometry calculations suggest that in the structure of the thrombin-bound hirudin peptides all the charged residues lie on the opposite side of a hydrophobic cluster formed by the nonpolar side chains of residues Phe(56), Ile(59), Pro(60), Tyr(63), and Leu(64).	Isoleucine	231-234	coagulation factor II, thrombin	Bos taurus	68-76
2345154-1	1990	Acetohydroxy acid synthase (AHAS; EC 4.1.3.18) catalyzes the following two parallel, physiologically important reactions: condensation of two molecules of pyruvate to form acetolactate (AL), in the pathway to valine and leucine, and condensation of pyruvate plus 2-ketobutyrate to form acetohydroxybutyrate (AHB), in the pathway to isoleucine.	Isoleucine	332-342	ilvB acetolactate synthase like	Homo sapiens	0-26
2345154-1	1990	Acetohydroxy acid synthase (AHAS; EC 4.1.3.18) catalyzes the following two parallel, physiologically important reactions: condensation of two molecules of pyruvate to form acetolactate (AL), in the pathway to valine and leucine, and condensation of pyruvate plus 2-ketobutyrate to form acetohydroxybutyrate (AHB), in the pathway to isoleucine.	Isoleucine	332-342	ilvB acetolactate synthase like	Homo sapiens	28-32
2075977-2	1990	One of these, DHFR-IQI, has three (Ile-Gln-Ile) and the other, DHFR-lek, has eight (Ile-Arg-Met-Tyr-Gly-Gly-Phe-Leu) additional amino acid residues at the C terminals; in both proteins, Cys152 of wild DHFR is replaced by Glu.	Isoleucine	35-38	dihydrofolate reductase	Homo sapiens	14-18
2105728-5	1990	The amino acid composition of calf apo-AI displayed an overall similarity to that of its human and other mammalian counterparts (baboon, dog, badger, rabbit, rat and mouse), but differed in having higher proportions of glutamic acid, alanine and isoleucine.	Isoleucine	246-256	APOAI	Bos taurus	35-41
2184838-3	1990	Finally, the results using the above plasma ANGs extend previous studies showing that the substrate specificity of human renin may be influenced by the amino acid residues at P2 (i.e., Ile, Val, or Tyr) and P3 (i.e., His or Tyr) sites.	Isoleucine	185-188	renin	Homo sapiens	121-126
11854440-6	2002	Within the M2-3 loop, substitution of residue 619 in NR2A (valine) for the corresponding NR2C residue (isoleucine) reduced inactivation without affecting calcium permeability of the channel.	Isoleucine	103-113	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	53-57
33818064-5	2021	Molecular docking suggested that residues Trp-588, Ile-590, and Arg-592 of Munc13-1 are involved in ligand interactions.	Isoleucine	51-54	unc-13 homolog A	Mus musculus	75-83
33818064-11	2021	This study shows that Trp-588, Ile-590, and Arg-592 are essential determinants for the activity of Munc13-1 and the effects of the three residues on the activity are ligand-dependent.	Isoleucine	31-34	unc-13 homolog A	Mus musculus	99-107
1970245-5	1990	These results were discussed in relation to the utilization of BCAA (leucine, isoleucine, and valine) for the synthesis of glutamate and glutamine in brain in hyperammonemic states.	Isoleucine	78-88	AT-rich interaction domain 4B	Rattus norvegicus	63-67
1974311-0	1990	The effect of plasma valine, isoleucine and leucine on the control of the flux through tyrosine- and tryptophan-hydroxylase in the brain.	Isoleucine	29-39	tyrosine hydroxylase	Homo sapiens	87-123
2342986-3	1990	Canine PYY(1-36) has the identical sequence as porcine and rat PYY but differs from human PYY at position 3, with Ala instead of Ile, and position 18, with Ser instead of Asn.	Isoleucine	129-132	peptide YY	Canis lupus familiaris	7-10
3096340-1	1986	A decapeptide corresponding to residues 35-44(-Thr-Ile-Glu-Asp-Ser-Tyr-Arg-Lys-Gln-Val-) of p21ras was synthesized.	Isoleucine	51-54	Harvey rat sarcoma virus oncogene	Mus musculus	92-98
11854440-6	2002	Within the M2-3 loop, substitution of residue 619 in NR2A (valine) for the corresponding NR2C residue (isoleucine) reduced inactivation without affecting calcium permeability of the channel.	Isoleucine	103-113	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	89-93
34687739-11	2022	Lack of SCFA and L-isoleucine biosynthesis significantly correlated with disease severity and increased plasma concentrations of CXCL-10, NT-proBNP, C-reactive protein (CRP) (all P < .05).	Isoleucine	17-29	C-X-C motif chemokine ligand 10	Homo sapiens	129-136
34687739-11	2022	Lack of SCFA and L-isoleucine biosynthesis significantly correlated with disease severity and increased plasma concentrations of CXCL-10, NT-proBNP, C-reactive protein (CRP) (all P < .05).	Isoleucine	17-29	C-reactive protein	Homo sapiens	149-167
34687739-11	2022	Lack of SCFA and L-isoleucine biosynthesis significantly correlated with disease severity and increased plasma concentrations of CXCL-10, NT-proBNP, C-reactive protein (CRP) (all P < .05).	Isoleucine	17-29	C-reactive protein	Homo sapiens	169-172
34974181-1	2021	BACKGROUND: The valine-to-isoleucine substitution (Val122Ile) is the most common variant of transthyretin (TTR) amyloidosis in the U.S., primarily affecting individuals of African descent.	Isoleucine	26-36	transthyretin	Homo sapiens	92-105
34607911-5	2022	Methods: We identified mitochondrial DNA (mtDNA) variants in three families with GS-like electrolyte abnormalities, then investigated 156 families for variants in MT-TI and MT-TF, which encode the transfer RNAs for phenylalanine and isoleucine.	Isoleucine	233-243	mitochondrially encoded tRNA isoleucine	Homo sapiens	163-168
34607911-5	2022	Methods: We identified mitochondrial DNA (mtDNA) variants in three families with GS-like electrolyte abnormalities, then investigated 156 families for variants in MT-TI and MT-TF, which encode the transfer RNAs for phenylalanine and isoleucine.	Isoleucine	233-243	mitochondrially encoded tRNA phenylalanine	Homo sapiens	173-178
34922186-4	2022	In each breed, there were eight nucleotide variations within the MTNR1A gene exon II, two of which (g.17355358 and g.17355171), respectively, resulted in a valine to isoleucine, and alanine to aspartic acid substitution, in amino acid sequence.	Isoleucine	166-176	melatonin receptor type 1A	Ovis aries	65-71
34821993-9	2022	The diabetic group and the insulin-resistant group had increased fecal values of valine and isoleucine (branched-chain amino acids), which were positively correlated with the progression of both conditions.	Isoleucine	92-102	insulin	Homo sapiens	27-34
34974181-1	2021	BACKGROUND: The valine-to-isoleucine substitution (Val122Ile) is the most common variant of transthyretin (TTR) amyloidosis in the U.S., primarily affecting individuals of African descent.	Isoleucine	26-36	transthyretin	Homo sapiens	107-110
34921512-3	2021	A large number of pairwise interactions were observed between the methyl protons of methionine, threonine, valine and isoleucine residues of gp120 and the aromatic tyrosine-protons of Nt-CCR5.	Isoleucine	118-128	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	141-146
34812595-9	2022	Analysis of TLR4 protein structure and properties suggested that the missense mutation on the 674th amino acid from Thr to Ile reduced the flexibility and hydrophilicity of TIR domain, implying a weakened binding ability of TLR4 to its adaptors.	Isoleucine	123-126	toll like receptor 4	Bos taurus	12-16
34812595-9	2022	Analysis of TLR4 protein structure and properties suggested that the missense mutation on the 674th amino acid from Thr to Ile reduced the flexibility and hydrophilicity of TIR domain, implying a weakened binding ability of TLR4 to its adaptors.	Isoleucine	123-126	toll like receptor 4	Bos taurus	224-228
34921512-3	2021	A large number of pairwise interactions were observed between the methyl protons of methionine, threonine, valine and isoleucine residues of gp120 and the aromatic tyrosine-protons of Nt-CCR5.	Isoleucine	118-128	C-C motif chemokine receptor 5	Homo sapiens	187-191
34863046-3	2022	BCAA plasma levels (isoleucine, leucine and valine) were measured at fasting and after 120 min of an oral glucose tolerance test (OGTT) at the baseline of the study and after 5 y of the dietary intervention.	Isoleucine	20-30	AT-rich interaction domain 4B	Homo sapiens	0-4
34505756-8	2021	The amino acid residues isoleucine, tyrosine, and leucine at positions 95, 116 and 163 of HLA-C, respectively, were associated with CIN II/III susceptibility.	Isoleucine	24-34	major histocompatibility complex, class I, C	Homo sapiens	90-95
34792756-7	2022	Here we present the near-complete backbone and Ile, Leu, and Val methyl group chemical shift assignments of the most C-terminal domain of nsp3, CoV-Y.	Isoleucine	47-50	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	138-142
34378357-1	2021	HLA-DRB1*15:123 has one nucleotide change from HLA-DRB1*15:01:01:01 where Threonine (90) is changed to Isoleucine.	Isoleucine	103-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
34378357-1	2021	HLA-DRB1*15:123 has one nucleotide change from HLA-DRB1*15:01:01:01 where Threonine (90) is changed to Isoleucine.	Isoleucine	103-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	47-55
34789813-5	2021	Indeed, NZH cows had lower (P-Tukey < 0.05) plasma concentrations of leucine, isoleucine and valine than NAH cows at 21 DIM, probably signaling for greater insulin sensitivity.	Isoleucine	78-88	insulin	Bos taurus	156-163
34382806-7	2021	Multiple amino acids (including alanine, glutamic acid, leucine, isoleucine, and phenylalanine), carnitines, and members of the fatty acid oxidation pathway were significantly increased in APP/PSEN1 mice on HFD compared to those on LFD.	Isoleucine	65-75	presenilin 1	Mus musculus	193-198
34603012-6	2021	Mapping of BCAA metabolism was performed using mass spectrometry and enriched (15N) and (13C) isotopes of leucine, isoleucine, and valine in acutely isolated slices of surgically resected cerebral cortical tissue from human brain and in hiPSC-derived brain cells carrying mutations in either amyloid precursor protein (APP) or presenilin-1 (PSEN-1).	Isoleucine	115-125	AT-rich interaction domain 4B	Homo sapiens	11-15
34114015-6	2021	In particular, higher hPDI was significantly associated with a higher relative abundance of Bacteroides cellulosilyticus and Eubacterium eligens, amino acid biosynthesis pathways (l-isoleucine biosynthesis I and III and l-valine biosynthesis), and the pathway of pyruvate fermentation to isobutanol.	Isoleucine	180-192	peptidyl arginine deiminase 1	Homo sapiens	22-26
34224307-5	2021	The amidohydrolases, including ILL6 and IAR3 and cytochrome P450 (CYP94B3), encoding JA-Ile catabolism were markedly depressed by ABA receptors.	Isoleucine	88-91	IAA-amino acid hydrolase ILR1-like 6	Arabidopsis thaliana	31-35
34224307-5	2021	The amidohydrolases, including ILL6 and IAR3 and cytochrome P450 (CYP94B3), encoding JA-Ile catabolism were markedly depressed by ABA receptors.	Isoleucine	88-91	peptidase M20/M25/M40 family protein	Arabidopsis thaliana	40-44
34224307-5	2021	The amidohydrolases, including ILL6 and IAR3 and cytochrome P450 (CYP94B3), encoding JA-Ile catabolism were markedly depressed by ABA receptors.	Isoleucine	88-91	cytochrome P450, family 94, subfamily B, polypeptide 3	Arabidopsis thaliana	66-73
34573680-1	2021	The objective of this study was to investigate changes in protein abundance of mTOR and insulin signaling pathway components along with amino acid (AA) transporters in bovine s.c. adipose (SAT) explants in response to increased supply of Leu, Ile, or Val.	Isoleucine	243-246	mechanistic target of rapamycin kinase	Bos taurus	79-83
34573680-1	2021	The objective of this study was to investigate changes in protein abundance of mTOR and insulin signaling pathway components along with amino acid (AA) transporters in bovine s.c. adipose (SAT) explants in response to increased supply of Leu, Ile, or Val.	Isoleucine	243-246	insulin	Bos taurus	88-95
34765396-3	2021	HSD10 is a multifunctional protein involved in enzymatic degradation of isoleucine and branched-chain fatty acids, the metabolism of sex hormones and neurosteroids, as well as in regulating mitochondrial RNA maturation.	Isoleucine	72-82	fibrous sheath interacting protein 1	Homo sapiens	0-5
34332225-9	2021	Optimum digestible Ile to Lys ratios for Exp 1 were determined to range from 0.640 to 0.725 for growth from 1.0 to 2.5 kg BW (P <= 0.001) and breast meat characteristics.	Isoleucine	19-22	exportin 1	Homo sapiens	41-46
34340727-6	2021	RESULTS: A total of 82 subjects were included, 15 subjects with a BCAT2 SNP had a greater reduction in leucine, isoleucine, valine, and the sum of BCAAs.	Isoleucine	112-122	branched chain amino acid transaminase 2	Homo sapiens	66-71
34489985-4	2021	In this study, we demonstrated that Ile application enhances plant resistance against B. cinerea in Arabidopsis, which is dependent on the JA receptor COI1 and the jasmonic acid-amido synthetase JAR1.	Isoleucine	36-39	RNI-like superfamily protein	Arabidopsis thaliana	151-155
34489985-4	2021	In this study, we demonstrated that Ile application enhances plant resistance against B. cinerea in Arabidopsis, which is dependent on the JA receptor COI1 and the jasmonic acid-amido synthetase JAR1.	Isoleucine	36-39	Auxin-responsive GH3 family protein	Arabidopsis thaliana	195-199
34454514-5	2021	RESULTS: We found a mutation, a threonine to isoleucine substitution at position 371 (T371I) in Gag, that restored replication competence to an IP6-binding-deficient HIV-1 mutant.	Isoleucine	45-55	Pr55(Gag)	Human immunodeficiency virus 1	96-99
34142125-6	2021	At the age of 4-5 weeks, Bcat2p.Q300*/p.Q300* mice displayed drastic increase of plasma levels of branch chain amino acids (BCAAs - leucine, isoleucine, valine) due to the incomplete catabolism of BCAAs, in addition to inducible arrhythmias ex vivo as well as cardiac conduction and repolarization disturbances.	Isoleucine	141-151	branched chain aminotransferase 2, mitochondrial	Mus musculus	25-31
34264743-1	2021	Backgrounds - Branched-chain amino acids (BCAAs; isoleucine, leucine and valine) correlate with insulin resistance and poor glucose control, which may in part explain associations between type 2 diabetes (T2D) and cardiovascular disease (CVD).	Isoleucine	49-59	insulin	Homo sapiens	96-103
34233759-6	2021	RESULTS: Thirteen metabolites were identified as common biomarkers discriminating ob/ob mice and lepb-/- zebrafish larvae from their respective wild type controls: alanine, citrulline, ethanolamine, glutamine, glycine, histidine, isoleucine, leucine, methionine, phenylalanine, putrescine, serine and threonine.	Isoleucine	230-240	leptin b	Danio rerio	97-101
34064996-7	2021	(3) Results: Amino acids alone did not affect plasma glucose or C-peptide, while isoleucine and valine, but not leucine, stimulated glucagon (p < 0.05), compared with control.	Isoleucine	81-91	glucagon	Homo sapiens	132-140
35245436-5	2022	Leucine and isoleucine, two branched-chain essential amino acids, strongly bind to and activate the E3 ubiquitin ligase Ubr1, targeting Plin2 for degradation.	Isoleucine	12-22	mitochondrial ubiquitin ligase activator of NFKB 1	Mus musculus	100-119
35583212-3	2022	A balanced BCAA ratio (Leu : Ile : Val = 2 : 2 : 1) significantly activated the mTOR pathway and upregulated the expression of amino acid transporters, such as ASCT2, SNAT2, LAT1, PAT1, and SLC38A9, simultaneously modulating mitochondrial function and muscle fiber composition, thereby inhibiting inflammatory cytokines, such as IL-6 and TNF-alpha, regulating amino acid metabolism, and ultimately increasing skeletal muscle mass.	Isoleucine	29-32	mechanistic target of rapamycin kinase	Sus scrofa	80-84
35583212-3	2022	A balanced BCAA ratio (Leu : Ile : Val = 2 : 2 : 1) significantly activated the mTOR pathway and upregulated the expression of amino acid transporters, such as ASCT2, SNAT2, LAT1, PAT1, and SLC38A9, simultaneously modulating mitochondrial function and muscle fiber composition, thereby inhibiting inflammatory cytokines, such as IL-6 and TNF-alpha, regulating amino acid metabolism, and ultimately increasing skeletal muscle mass.	Isoleucine	29-32	solute carrier family 1 member 5	Sus scrofa	160-165
35583212-3	2022	A balanced BCAA ratio (Leu : Ile : Val = 2 : 2 : 1) significantly activated the mTOR pathway and upregulated the expression of amino acid transporters, such as ASCT2, SNAT2, LAT1, PAT1, and SLC38A9, simultaneously modulating mitochondrial function and muscle fiber composition, thereby inhibiting inflammatory cytokines, such as IL-6 and TNF-alpha, regulating amino acid metabolism, and ultimately increasing skeletal muscle mass.	Isoleucine	29-32	solute carrier family 38 member 2	Sus scrofa	167-172
35583212-3	2022	A balanced BCAA ratio (Leu : Ile : Val = 2 : 2 : 1) significantly activated the mTOR pathway and upregulated the expression of amino acid transporters, such as ASCT2, SNAT2, LAT1, PAT1, and SLC38A9, simultaneously modulating mitochondrial function and muscle fiber composition, thereby inhibiting inflammatory cytokines, such as IL-6 and TNF-alpha, regulating amino acid metabolism, and ultimately increasing skeletal muscle mass.	Isoleucine	29-32	L-type amino acid transporter 1	Sus scrofa	174-178
35583212-3	2022	A balanced BCAA ratio (Leu : Ile : Val = 2 : 2 : 1) significantly activated the mTOR pathway and upregulated the expression of amino acid transporters, such as ASCT2, SNAT2, LAT1, PAT1, and SLC38A9, simultaneously modulating mitochondrial function and muscle fiber composition, thereby inhibiting inflammatory cytokines, such as IL-6 and TNF-alpha, regulating amino acid metabolism, and ultimately increasing skeletal muscle mass.	Isoleucine	29-32	solute carrier family 38 member 9	Sus scrofa	190-197
35583212-3	2022	A balanced BCAA ratio (Leu : Ile : Val = 2 : 2 : 1) significantly activated the mTOR pathway and upregulated the expression of amino acid transporters, such as ASCT2, SNAT2, LAT1, PAT1, and SLC38A9, simultaneously modulating mitochondrial function and muscle fiber composition, thereby inhibiting inflammatory cytokines, such as IL-6 and TNF-alpha, regulating amino acid metabolism, and ultimately increasing skeletal muscle mass.	Isoleucine	29-32	interleukin 6	Sus scrofa	329-333
35583212-3	2022	A balanced BCAA ratio (Leu : Ile : Val = 2 : 2 : 1) significantly activated the mTOR pathway and upregulated the expression of amino acid transporters, such as ASCT2, SNAT2, LAT1, PAT1, and SLC38A9, simultaneously modulating mitochondrial function and muscle fiber composition, thereby inhibiting inflammatory cytokines, such as IL-6 and TNF-alpha, regulating amino acid metabolism, and ultimately increasing skeletal muscle mass.	Isoleucine	29-32	tumor necrosis factor	Sus scrofa	338-347
35379539-3	2022	The traditional model of PKU neuropathophysiology dictates blood Phe over-representation directs asymmetric blood:brain barrier amino acid transport through the LAT1 transporter with subsequent increased cerebral Phe concentration and low concentrations of tyrosine (Tyr), tryptophan (Trp), leucine (Leu), valine (Val), and isoleucine (Ile).	Isoleucine	324-334	solute carrier family 7 member 5	Homo sapiens	161-165
35379539-3	2022	The traditional model of PKU neuropathophysiology dictates blood Phe over-representation directs asymmetric blood:brain barrier amino acid transport through the LAT1 transporter with subsequent increased cerebral Phe concentration and low concentrations of tyrosine (Tyr), tryptophan (Trp), leucine (Leu), valine (Val), and isoleucine (Ile).	Isoleucine	336-339	solute carrier family 7 member 5	Homo sapiens	161-165
35621914-6	2022	Furthermore, many metabolites known to affect insulin action and metabolism were altered by hyperglucagonemia including increase in branched amino acids and keto acids of leucine and isoleucine in arterial plasma.	Isoleucine	183-193	insulin	Homo sapiens	46-53
34094836-1	2021	Bcr-Abl threonine 315 to isoleucine 315 (T315I) gatekeeper mutation induced drug resistance remains an unmet clinical challenge for the treatment of chronic myeloid leukemia (CML).	Isoleucine	25-35	BCR activator of RhoGEF and GTPase	Mus musculus	0-3
35593529-0	2022	Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodeling.	Isoleucine	0-10	mechanistic target of rapamycin kinase	Mus musculus	22-26
35593529-0	2022	Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodeling.	Isoleucine	0-10	sterol regulatory element binding transcription factor 1	Mus musculus	31-39
35593529-0	2022	Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodeling.	Isoleucine	0-10	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	111-115
35593529-3	2022	Ile dose-dependently affected milk protein and fat synthesis, mTOR phosphorylation, SREBP-1c expression and maturation, and BRG1 protein expression in bovine MECs.	Isoleucine	0-3	casein kappa	Bos taurus	30-42
35593529-3	2022	Ile dose-dependently affected milk protein and fat synthesis, mTOR phosphorylation, SREBP-1c expression and maturation, and BRG1 protein expression in bovine MECs.	Isoleucine	0-3	mechanistic target of rapamycin kinase	Bos taurus	62-66
35593529-3	2022	Ile dose-dependently affected milk protein and fat synthesis, mTOR phosphorylation, SREBP-1c expression and maturation, and BRG1 protein expression in bovine MECs.	Isoleucine	0-3	sterol regulatory element binding transcription factor 1	Mus musculus	84-92
35593529-3	2022	Ile dose-dependently affected milk protein and fat synthesis, mTOR phosphorylation, SREBP-1c expression and maturation, and BRG1 protein expression in bovine MECs.	Isoleucine	0-3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Bos taurus	124-128
35593529-6	2022	ChIP-PCR analysis detected that BRG1 bound to the promoters of mTOR and SREBP-1c, and ChIP-qPCR further detected that these binding were increased by Ile stimulation.	Isoleucine	150-153	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Bos taurus	32-36
35593529-6	2022	ChIP-PCR analysis detected that BRG1 bound to the promoters of mTOR and SREBP-1c, and ChIP-qPCR further detected that these binding were increased by Ile stimulation.	Isoleucine	150-153	mechanistic target of rapamycin kinase	Bos taurus	63-67
35593529-6	2022	ChIP-PCR analysis detected that BRG1 bound to the promoters of mTOR and SREBP-1c, and ChIP-qPCR further detected that these binding were increased by Ile stimulation.	Isoleucine	150-153	sterol regulatory element binding transcription factor 1	Mus musculus	72-80
35299066-1	2022	This review provides insight into the effects of the branched-chain amino acids (BCAA: leucine, isoleucine, and valine) on the growth, production performance, immunity, and intestinal health of poultry.	Isoleucine	96-106	AT-rich interaction domain 4B	Homo sapiens	81-85
35245436-5	2022	Leucine and isoleucine, two branched-chain essential amino acids, strongly bind to and activate the E3 ubiquitin ligase Ubr1, targeting Plin2 for degradation.	Isoleucine	12-22	Ubr1 ubiquitin ligase	Drosophila melanogaster	120-124
35245436-5	2022	Leucine and isoleucine, two branched-chain essential amino acids, strongly bind to and activate the E3 ubiquitin ligase Ubr1, targeting Plin2 for degradation.	Isoleucine	12-22	Lipid storage droplet-2	Drosophila melanogaster	136-141
35417448-1	2022	In a previous study with LSL-LITE layers (-23 to 30-week-old), isoleucine at 0.72% and 0.84% produced values for FCR at 1.45 and 1.44, respectively and shared significance with 0.78% isoleucine (1.49).	Isoleucine	63-73	FCR	Gallus gallus	113-116
35417448-1	2022	In a previous study with LSL-LITE layers (-23 to 30-week-old), isoleucine at 0.72% and 0.84% produced values for FCR at 1.45 and 1.44, respectively and shared significance with 0.78% isoleucine (1.49).	Isoleucine	183-193	FCR	Gallus gallus	113-116
35417448-6	2022	An isoleucine:valine of 1.233 corresponding to 0.72% isoleucine and 0.87% valine produced the lowest FCR of 1.30 (a 2.26% decrease compared to the Control at 1.33 +- 0.04).	Isoleucine	3-13	FCR	Gallus gallus	101-104
35417448-6	2022	An isoleucine:valine of 1.233 corresponding to 0.72% isoleucine and 0.87% valine produced the lowest FCR of 1.30 (a 2.26% decrease compared to the Control at 1.33 +- 0.04).	Isoleucine	53-63	FCR	Gallus gallus	101-104
35041077-9	2022	Growth defects observed when set1Delta cultures were starved for isoleucine and valine were also rescued by wild-type SET1 or partial-function set1 alleles.	Isoleucine	65-75	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	118-122
35409380-1	2022	Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino acids widely studied for their crucial role in the regulation of protein synthesis mainly through the activation of the mTOR signaling pathway and their emerging recognition as players in the regulation of various physiological and metabolic processes, such as glucose homeostasis.	Isoleucine	45-55	mechanistic target of rapamycin kinase	Homo sapiens	208-212
35041077-9	2022	Growth defects observed when set1Delta cultures were starved for isoleucine and valine were also rescued by wild-type SET1 or partial-function set1 alleles.	Isoleucine	65-75	histone methyltransferase SET1	Saccharomyces cerevisiae S288C	143-147
35391802-10	2022	In addition, we found that V739I variants of ACE2, which functions as the receptor for SARS-CoVs, were heterozygous in Vero JCRB0111, Vero CCL-81, and Vero 76; however, Vero E6 harbored only the allele with isoleucine, resulting from the loss of one of the X chromosomes.	Isoleucine	207-217	angiotensin converting enzyme 2	Homo sapiens	45-49
35328720-7	2022	In conclusion, supplementation with a combination of Val and Ile into the VLP diets restored the decreased growth performance of pigs fed with these diets likely through improved gut development, hepatic IGF-1 expression and bioavailability, and plasma metabolomics profile.	Isoleucine	61-64	insulin like growth factor 1	Sus scrofa	204-209
35360198-8	2022	The results revealed that leucine and isoleucine increased cell proliferation, total antioxidant status (TAS), and the relative mRNA expression of occludin, as well as decreased malondialdehyde (MDA), total oxidant status (TOS)/TAS, IL-6, IL-1beta, and TOS.	Isoleucine	38-48	occludin	Bos taurus	147-155
35360198-8	2022	The results revealed that leucine and isoleucine increased cell proliferation, total antioxidant status (TAS), and the relative mRNA expression of occludin, as well as decreased malondialdehyde (MDA), total oxidant status (TOS)/TAS, IL-6, IL-1beta, and TOS.	Isoleucine	38-48	interferon beta-2	Bos taurus	233-237
35360198-8	2022	The results revealed that leucine and isoleucine increased cell proliferation, total antioxidant status (TAS), and the relative mRNA expression of occludin, as well as decreased malondialdehyde (MDA), total oxidant status (TOS)/TAS, IL-6, IL-1beta, and TOS.	Isoleucine	38-48	interleukin 1 alpha	Bos taurus	239-247
35360198-9	2022	When leucine and isoleucine were combined, MDA, TOS/TAS, and the relative mRNA expression levels of claudin-1, occludin, and zonula occludens-1 increased when compared to leucine or isoleucine alone.	Isoleucine	17-27	claudin 1	Bos taurus	100-109
35360198-9	2022	When leucine and isoleucine were combined, MDA, TOS/TAS, and the relative mRNA expression levels of claudin-1, occludin, and zonula occludens-1 increased when compared to leucine or isoleucine alone.	Isoleucine	17-27	occludin	Bos taurus	111-119
35360198-9	2022	When leucine and isoleucine were combined, MDA, TOS/TAS, and the relative mRNA expression levels of claudin-1, occludin, and zonula occludens-1 increased when compared to leucine or isoleucine alone.	Isoleucine	182-192	claudin 1	Bos taurus	100-109
35328720-0	2022	A Mixture of Valine and Isoleucine Restores the Growth of Protein-Restricted Pigs Likely through Improved Gut Development, Hepatic IGF-1 Pathway, and Plasma Metabolomic Profile.	Isoleucine	24-34	insulin like growth factor 1	Sus scrofa	131-136
35267786-5	2022	Results showed a high quality of the extracted-elastin with the presence of a high amount of proline (6.55 +- 0.40%) and glycine (9.65 +- 0.44%), low amount of hydroxyproline (0.80 +- 0.32%), methionine (2.04 +- 0.05%), and histidine (1.81 +- 0.05%) together with calculated 0.56 isoleucine/leucine ratio.	Isoleucine	280-290	elastin	Bos taurus	47-54
35441136-11	2022	Isoleucine is metabolized via methylmalonyl-CoA mutase encoded by the gene MMUT in a reaction that consumes vitamin B12.	Isoleucine	0-10	methylmalonyl-CoA mutase	Homo sapiens	30-54
35262078-4	2022	A structural model reproducibly predicted a binding mode where the pyrrolo pyrimidine forms a hydrogen bonding network with Asp 22 and the amide backbone NH of Ile 23 in the adenosine binding pocket and the carboxylate forms hydrogen bonds to the amide backbone of Phe 157 and Asp 156 , part of the oxyanion subsite of Mac1.	Isoleucine	160-163	integrin subunit alpha M	Homo sapiens	319-323
35281467-11	2022	Moreover, highly expressed CYBRD1, GNG12, and SMAD1, which were identified as hub genes, may be associated with "valine leucine and isoleucine degradation," "base excision repair," and "fatty acid metabolism," respectively, according to the results of single gene-based genomes and gene set enrichment analysis (GSEA).	Isoleucine	132-142	cytochrome b reductase 1	Homo sapiens	27-33
35281467-11	2022	Moreover, highly expressed CYBRD1, GNG12, and SMAD1, which were identified as hub genes, may be associated with "valine leucine and isoleucine degradation," "base excision repair," and "fatty acid metabolism," respectively, according to the results of single gene-based genomes and gene set enrichment analysis (GSEA).	Isoleucine	132-142	G protein subunit gamma 12	Homo sapiens	35-40
35281467-11	2022	Moreover, highly expressed CYBRD1, GNG12, and SMAD1, which were identified as hub genes, may be associated with "valine leucine and isoleucine degradation," "base excision repair," and "fatty acid metabolism," respectively, according to the results of single gene-based genomes and gene set enrichment analysis (GSEA).	Isoleucine	132-142	SMAD family member 1	Homo sapiens	46-51
35281467-11	2022	Moreover, highly expressed CYBRD1, GNG12, and SMAD1, which were identified as hub genes, may be associated with "valine leucine and isoleucine degradation," "base excision repair," and "fatty acid metabolism," respectively, according to the results of single gene-based genomes and gene set enrichment analysis (GSEA).	Isoleucine	132-142	ELAV like RNA binding protein 2	Homo sapiens	78-81
35142326-5	2022	Our enzymatic work demonstrates that human SETD3 can accommodate structurally diverse hydrophobic side chains in its Ile71 binding pocket, providing clear limits of the size and shape of Ile analogues.	Isoleucine	187-190	SET domain containing 3, actin histidine methyltransferase	Homo sapiens	43-48
35087537-0	2021	l-Isoleucine Administration Alleviates DSS-Induced Colitis by Regulating TLR4/MyD88/NF-kappaB Pathway in Rats.	Isoleucine	0-12	toll-like receptor 4	Rattus norvegicus	73-77
35273875-1	2022	Beta-ketothiolase (mitochondrial acetoacetyl-CoA thiolase, T2) deficiency is a rare inborn error of metabolism that is characterized by impaired metabolism of ketones and isoleucine.	Isoleucine	171-181	acetyl-CoA acyltransferase 1	Homo sapiens	0-17
35273875-1	2022	Beta-ketothiolase (mitochondrial acetoacetyl-CoA thiolase, T2) deficiency is a rare inborn error of metabolism that is characterized by impaired metabolism of ketones and isoleucine.	Isoleucine	171-181	acetyl-CoA acetyltransferase 1	Homo sapiens	19-57
35061687-11	2022	Isoleucine at 0.72%, 0.81%, and 0.84% produced the lowest FCR, an important standard in the poultry industry.	Isoleucine	0-10	FCR	Gallus gallus	58-61
35087537-0	2021	l-Isoleucine Administration Alleviates DSS-Induced Colitis by Regulating TLR4/MyD88/NF-kappaB Pathway in Rats.	Isoleucine	0-12	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	78-83
35087537-0	2021	l-Isoleucine Administration Alleviates DSS-Induced Colitis by Regulating TLR4/MyD88/NF-kappaB Pathway in Rats.	Isoleucine	0-12	nuclear factor kappa B subunit 1	Homo sapiens	84-93
35087537-4	2021	In the in vitro trial, IEC-18 cells were treated by 4 mmol/L l-isoleucine for 12 h, which relieved the decrease of cell viability that was induced by TNF-alpha (10 ng/ml) challenge for 24 h (P <0.05).	Isoleucine	61-73	tumor necrosis factor	Rattus norvegicus	150-159
35087537-9	2021	These results suggest that supplementing l-isoleucine in diet improved the DSS-induced growth stunting and colonic damage in rats, which could be associated with the downregulation of inflammation via regulating TLR4/MyD88/NF-kappaB pathway in colon.	Isoleucine	41-53	toll-like receptor 4	Rattus norvegicus	212-216
35087537-9	2021	These results suggest that supplementing l-isoleucine in diet improved the DSS-induced growth stunting and colonic damage in rats, which could be associated with the downregulation of inflammation via regulating TLR4/MyD88/NF-kappaB pathway in colon.	Isoleucine	41-53	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	217-222
35087537-9	2021	These results suggest that supplementing l-isoleucine in diet improved the DSS-induced growth stunting and colonic damage in rats, which could be associated with the downregulation of inflammation via regulating TLR4/MyD88/NF-kappaB pathway in colon.	Isoleucine	41-53	nuclear factor kappa B subunit 1	Homo sapiens	223-232
2607155-5	1989	N terminal amino acid sequence analysis of purified hIL-5 revealed that a single amino-terminal amino acid (isoleucine) is detected and hIL-5 consists of 115 amino acid residues.	Isoleucine	108-118	interleukin 5	Homo sapiens	52-57
35046895-13	2021	We found substantial enrichment of insulin signaling and other T2DM-related pathways, such as valine, leucine and isoleucine biosynthesis, serine and threonine metabolism, adipocytokine signaling pathway, P13K/Akt pathway, and Hedgehog signaling pathway.	Isoleucine	114-124	insulin	Homo sapiens	35-42
2527855-8	1989	Laminin-binding by the alpha beta 1 complex was independent of Arg-Gly-Asp or Tyr-Ile-Gly-Ser-Arg-like sequences, but required the presence of divalent cations.	Isoleucine	82-85	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-35
2605228-7	1989	Furthermore, the substitution of Ile-35 in two IGF II fragments (residues 21-45 and 31-55) by Ser inactivated these fragments.	Isoleucine	33-36	insulin-like growth factor 2	Rattus norvegicus	47-53
2605228-8	1989	This suggests that Ile-35 is an essential residue for IGF II fragment activity.	Isoleucine	19-22	insulin-like growth factor 2	Rattus norvegicus	54-60
2605228-9	1989	Ser-35, which was reported in the original sequencing of bovine IGF II, is incorrect in the sequence and furthermore has been consistently found to be an Ile-35 in our hands.	Isoleucine	154-157	insulin like growth factor 2	Bos taurus	64-70
2687266-9	1989	Since isoleucine and serine enhanced both MIR and insulin sensitivity of the protein synthesis system without influencing the GTS, it appears that amino acids can influence several insulin effector systems with notable differences in rapidity of action, direction of regulation, and specificity of amino acids.	Isoleucine	6-16	insulin	Homo sapiens	50-57
2555519-6	1989	However, sequence homologies of the CDR2 regions of all the antibodies indicate that residues Glu H-50, Ile H-51, Pro H-52a and Tyr H-59 are conserved, and that these segments may be more critically involved in binding than the other H and L-chain hypervariable regions.	Isoleucine	104-107	cerebellar degeneration-related 2	Mus musculus	36-40
16594052-1	1989	Acetolactate synthase (ALS; EC 4.1.3.18) is the first common enzyme in the biosynthetic pathways leading to leucine, isoleucine, and valine.	Isoleucine	117-127	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	23-26
2614645-1	1989	A novel inhibitor of angiotensin-converting enzyme (ACE) derived from tuna muscle, Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (tuna AI), was chemically synthesized, and its biological properties were investigated.	Isoleucine	95-98	angiotensin-converting enzyme	Oryctolagus cuniculus	52-55
2520246-1	1989	Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side-products, including a component 12 Da higher in mass.	Isoleucine	112-115	renin	Homo sapiens	55-60
2587421-8	1989	Human PYY(1-36) differs from porcine PYY only at position 3, with Ile instead of Ala, and position 18, with Asn instead of Ser.	Isoleucine	66-69	peptide YY	Homo sapiens	6-9
2666327-10	1989	The human urinary kallikrein contains 238 amino acid residues with Ile and Ser as N- and C-terminal amino acids, respectively.	Isoleucine	67-70	kallikrein related peptidase 4	Homo sapiens	18-28
2715129-2	1989	Fifty percent of this increase could be attributed to three of the EAA: the branched-chain amino acids (BCAA: Leu Ile and Val).	Isoleucine	114-117	AT-rich interaction domain 4B	Rattus norvegicus	104-108
2772920-2	1989	Three branched chain amino acids (BCAA: valine + leucine + isoleucine) were decreased in all three diseases in comparison with controls.	Isoleucine	59-69	AT-rich interaction domain 4B	Homo sapiens	34-38
2499329-2	1989	Glucose-6-phosphate dehydrogenase from the yeast Pichia jadinii has a reactive lysine residue in a segment of amino acid sequence Ile-Asp-His-Tyr-Leu-Gly-Lys*-Glu-Met-Val-Lys.	Isoleucine	130-133	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
2470848-15	1989	The apoB allotype MB19(1) is associated with an Ile at residue 71 and the absence of the ApaLI site, whereas the apoB allotype MB19(2) is associated with a Thr at residue 71 and the presence of the ApaLI site.	Isoleucine	48-51	apolipoprotein B	Homo sapiens	4-8
2665960-3	1989	In this insulin, the isoleucine residue in position A2, invariant in the majority of mammalian insulins, is substituted by valine.	Isoleucine	21-31	insulin	Homo sapiens	8-15
2665960-8	1989	We suggest that the substitution of valine for isoleucine at position A2 is responsible for all or most of the diminution in potency of owl monkey insulin relative to porcine insulin.	Isoleucine	47-57	insulin	Bos taurus	147-154
2665960-8	1989	We suggest that the substitution of valine for isoleucine at position A2 is responsible for all or most of the diminution in potency of owl monkey insulin relative to porcine insulin.	Isoleucine	47-57	insulin	Bos taurus	175-182
2493268-2	1989	The pancreatic stone protein isolated from human calculi (PSP) derives from the immunoreactive protein forms detected in human pancreatic juice (PSP S2-5) through the tryptic cleavage of the Arg-11-Ile-12 bond.	Isoleucine	198-201	regenerating family member 1 alpha	Homo sapiens	58-61
2497702-9	1989	Kinetic analysis of crude isoleucyl-tRNA synthetase from trained and untrained B. subtilis strains revealed differences in apparent Ki for mupirocin (resistant strain SB23T, Ki = 71.1 nM; sensitive strain SB23, Ki = 33.5 nM), while the Km for isoleucine remained unchanged (2.7 to 2.9 microM).	Isoleucine	243-253	isoleucyl-tRNA synthetase	Staphylococcus aureus	26-51
2492791-1	1989	Site-specific mutants of human Cu,Zn superoxide dismutase (Cu,ZnSOD) have been prepared in which the active-site arginine at position 143 (i.e., SODR143) has been replaced by either lysine (SODK143) or isoleucine (SODI143).	Isoleucine	202-212	superoxide dismutase 1	Homo sapiens	31-57
2492791-1	1989	Site-specific mutants of human Cu,Zn superoxide dismutase (Cu,ZnSOD) have been prepared in which the active-site arginine at position 143 (i.e., SODR143) has been replaced by either lysine (SODK143) or isoleucine (SODI143).	Isoleucine	202-212	superoxide dismutase 1	Homo sapiens	59-67
2644251-9	1989	Isoleucine and serine together increased both insulin sensitivity and responsiveness to 60-70% of that seen with the full complement of amino acids.	Isoleucine	0-10	insulin	Homo sapiens	46-53
2497702-10	1989	A Km of 0.4 micromolar isoleucine and Ki of 24 nM mupirocin was demonstrated for isoleucyl-tRNA synthetase from sensitive S. aureus 730a, while no isoleucyl-tRNA synthetase activity was detected in extracts of resistance-trained S. aureus 3000 even at 40 micromolar isoleucine, suggesting instability of the enzyme.	Isoleucine	23-33	isoleucyl-tRNA synthetase	Staphylococcus aureus	81-106
2467054-4	1989	Increased concentrations of aromatic amino acids: phenylalanine and tyrosine, and low concentrations of branched-chain amino acids: valine, leucine, and isoleucine were associated with a decrease of Fisher"s index (BCAA/AAA molar ratio) from 3.0 +/- 0.5 (normal) to 2.0 +/- 0.5 which was of high diagnostic and prognostic significance.	Isoleucine	153-163	AT-rich interaction domain 4B	Homo sapiens	215-219
2603816-5	1989	It has been shown from the sequence of kallikrein that Arg(-1)-Ile(1) and Arg(87)-Gln(88) bonds are hydrolyzed with trypsin on rapid activation of prokallikrein and the formation of disulfide-linked two chain kallikrein.	Isoleucine	63-66	kallikrein related peptidase 4	Homo sapiens	39-49
2603816-5	1989	It has been shown from the sequence of kallikrein that Arg(-1)-Ile(1) and Arg(87)-Gln(88) bonds are hydrolyzed with trypsin on rapid activation of prokallikrein and the formation of disulfide-linked two chain kallikrein.	Isoleucine	63-66	kallikrein related peptidase 4	Homo sapiens	150-160
2485094-2	1989	We discovered an 8 amino acid region (Leu-Ser-Glu-Asp-Leu-Leu-Ser- Ile in human TPO) in which there were 6 identical and 2 conserved amino acid residues when compared with human Tg.	Isoleucine	67-70	thyroid peroxidase	Homo sapiens	80-83
2680252-2	1989	The pancreatic stone protein (PSP, Mr 15,000) which has been discovered in human calculi derives from the native glycosylated forms of the protein (Mrs 17,500-22,000) which are present in human pancreatic juice through tryptic cleavage of the Arg 11-Ile 12 bond.	Isoleucine	250-253	regenerating family member 1 alpha	Homo sapiens	4-28
2680252-2	1989	The pancreatic stone protein (PSP, Mr 15,000) which has been discovered in human calculi derives from the native glycosylated forms of the protein (Mrs 17,500-22,000) which are present in human pancreatic juice through tryptic cleavage of the Arg 11-Ile 12 bond.	Isoleucine	250-253	regenerating family member 1 alpha	Homo sapiens	30-33
3069583-1	1988	The yeast ILV2 gene encodes acetolactate synthase, the first enzyme in the biosynthesis of isoleucine and valine.	Isoleucine	91-101	acetolactate synthase catalytic subunit	Saccharomyces cerevisiae S288C	10-14
2536164-2	1989	Second-site reversions that produced Asn-57----Ile replacements at least partially restored function, presumably by alleviating the instability of these two altered iso-1-cytochromes c. Introduction of the Ile-57 replacement by site-directed mutagenesis in an otherwise normal protein resulted in a 17 degrees C increase in the transition temperature (Tm), corresponding to over a 2-fold increase in the free energy change (delta G degrees) for thermal unfolding.	Isoleucine	47-50	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	165-170
2760302-5	1989	The structure of the peptide was Tyr-Ile-Pro-Ile-Gln-Tyr-Val-Leu-Ser-Arg, which corresponded to kappa-casein (25-34).	Isoleucine	37-40	casein kappa	Bos taurus	96-108
3202875-4	1988	The differences between the structures of porcine and human PYY are at positions 3 (Ala/Ile replacement) and 18 (Ser/Asn).	Isoleucine	88-91	peptide YY	Homo sapiens	60-63
3392535-3	1988	Following incubation with 3H-labeled isoleucine, radioactively labeled angiotensinogen with an approximate molecular weight of 25,000 was identified in both glial and neuronal cells.	Isoleucine	37-47	angiotensinogen	Rattus norvegicus	71-86
2972276-7	1988	Using purified endopeptidase 24.11, we identified seven sites of hydrolysis in unlabelled alpha-hANP: the bonds Arg-4-Ser-5, Cys-7-Phe-8, Arg-11-Met-12, Arg-14-Ile-15, Gly-16-Ala-17, Gly-20-Leu-21 and Ser-25-Phe-26.	Isoleucine	160-163	natriuretic peptide A	Homo sapiens	96-100
3147713-6	1988	PSP and PSP S1 are generated by the cleavage of an Arg-Ile bond in the N-terminal part of PSP S2-5.	Isoleucine	55-58	regenerating family member 1 alpha	Homo sapiens	0-3
3147713-6	1988	PSP and PSP S1 are generated by the cleavage of an Arg-Ile bond in the N-terminal part of PSP S2-5.	Isoleucine	55-58	regenerating family member 1 alpha	Homo sapiens	8-14
3147713-6	1988	PSP and PSP S1 are generated by the cleavage of an Arg-Ile bond in the N-terminal part of PSP S2-5.	Isoleucine	55-58	regenerating family member 1 alpha	Homo sapiens	8-11
3403546-6	1988	The cofilin sequence contains a hexapeptide (Asp-Ala-Ile-Lys-Lys-Lys) identical to the amino-terminal sequence (residues 2-7) of muscle and nonmuscle tropomyosin.	Isoleucine	53-56	cofilin 1	Homo sapiens	4-11
3289762-1	1988	The threonine deaminase gene (ILV1) of Saccharomyces cerevisiae has been designated "multifunctional" since Bollon (1974) indicated its involvement both in the catalysis of the first step in isoleucine biosynthesis and in the regulation of the isoleucine-valine pathway.	Isoleucine	191-201	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	30-34
2454348-10	1988	In contrast, if cells whose growth was arrested in ethionine-containing medium or in isoleucine-deficient medium were refed mitogenic medium containing TGF-beta, significant DNA synthesis was detected.	Isoleucine	85-95	transforming growth factor beta 1	Homo sapiens	152-160
2896620-5	1988	This transversion predicts an amino acid substitution from isoleucine (ATT) to methionine (ATG) in codon 132, which is located within the putative 5"-phosphoribosyl-1-pyrophosphate (PRPP)-binding site of HPRT.	Isoleucine	59-69	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	204-208
3390164-10	1988	Bovine IGF-2 was found to differ in three residues of the C-domain compared with human IGF-2, with serine, isoleucine and asparagine substituted for alanine, valine and serine respectively at positions 32, 35 and 36.	Isoleucine	107-117	insulin like growth factor 2	Bos taurus	7-12
3289762-1	1988	The threonine deaminase gene (ILV1) of Saccharomyces cerevisiae has been designated "multifunctional" since Bollon (1974) indicated its involvement both in the catalysis of the first step in isoleucine biosynthesis and in the regulation of the isoleucine-valine pathway.	Isoleucine	244-254	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	30-34
2435588-0	1987	Vasoactive intestinal peptide and peptide with N-terminal histidine and C-terminal isoleucine increase prolactin secretion in cultured rat pituitary cells (GH4C1) via a cAMP-dependent mechanism which involves transient elevation of intracellular Ca2+.	Isoleucine	83-93	prolactin	Rattus norvegicus	103-112
3257825-6	1988	In codon 172 of the mutant gene, the normal codon ATC, encoding isoleucine, has been changed to AAC, encoding asparagine.	Isoleucine	64-74	glycine-N-acyltransferase	Homo sapiens	96-99
3125490-5	1987	Rat and human corticotropin releasing factor but not ovine also have an amidated isoleucine in C-terminal position.	Isoleucine	81-91	corticotropin releasing hormone	Homo sapiens	14-44
3118367-7	1987	One of these replacements is the conservative substitution of valine for isoleucine at position A2, an invariant site in all other vertebrate insulins and insulin-like growth factors.	Isoleucine	73-83	insulin	Homo sapiens	142-149
3112154-1	1987	The active site arginine-143 of human Cu,Zn superoxide dismutase has been replaced by lysine or by isoleucine.	Isoleucine	99-109	superoxide dismutase 1	Homo sapiens	38-64
3652906-4	1987	Three substitutions are within the predicted rat IGF-I sequence: a Pro for Asp in the B domain, an Ile for Ser in the C domain, and Thr for Ala in the D domain.	Isoleucine	99-102	insulin-like growth factor 1	Rattus norvegicus	49-54
3108036-0	1987	Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein.	Isoleucine	20-23	regenerating family member 1 alpha	Homo sapiens	70-94
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Isoleucine	238-241	regenerating family member 1 alpha	Homo sapiens	34-37
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Isoleucine	238-241	regenerating family member 1 alpha	Homo sapiens	145-148
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Isoleucine	238-241	regenerating family member 1 alpha	Homo sapiens	180-186
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Isoleucine	238-241	regenerating family member 1 alpha	Homo sapiens	145-148
3563885-5	1987	Patients receiving the 45% BCAA solution had significant mean uptake of total BCAA, leucine, and isoleucine compared with results in patients receiving the 25% BCAA solution.	Isoleucine	97-107	AT-rich interaction domain 4B	Homo sapiens	27-31
16665813-1	1987	Acetolactate synthase (ALS) is the first common enzyme in the biosynthetic pathways to valine, isoleucine, and leucine.	Isoleucine	95-105	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	23-26
3497920-1	1987	The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-ethyl ester, having the amino acid sequence around the SH1 of myosin heavy chain, was coprecipitated with F-actin after ultracentrifugation.	Isoleucine	17-20	myosin heavy chain 14	Homo sapiens	107-113
3302681-3	1987	Functional complementation by the ILV1 gene product was demonstrated by the selection of several transformed lines on a medium without isoleucine and by the identification in these lines of the yeast threonine dehydratase activity.	Isoleucine	135-145	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	34-38
2437111-2	1987	Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine.	Isoleucine	269-279	optineurin	Homo sapiens	7-10
2956497-3	1987	Similarly, poor immunoreactivity of human ANF indicates the participation of isoleucine 110.	Isoleucine	77-87	natriuretic peptide A	Homo sapiens	42-45
2435588-1	1987	Vasoactive intestinal peptide (VIP) and peptide (P) with N-terminal histidine and C-terminal isoleucine (PHI) stimulated prolactin (PRL) secretion from GH4C1 cells equipotent with ED50 values of 30-50 nM.	Isoleucine	93-103	prolactin	Rattus norvegicus	121-130
2435588-1	1987	Vasoactive intestinal peptide (VIP) and peptide (P) with N-terminal histidine and C-terminal isoleucine (PHI) stimulated prolactin (PRL) secretion from GH4C1 cells equipotent with ED50 values of 30-50 nM.	Isoleucine	93-103	prolactin	Rattus norvegicus	132-135
2485065-3	1987	The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).	Isoleucine	199-202	angiotensinogen	Homo sapiens	139-154
2485065-5	1987	The homologous fungal aspartic proteinase, endothiapepsin, has been cocrystallised with human renin inhibitors of the type His-Pro-Phe-His-Leu-R-Val-Ile-His, where R indicates a reduced carbonyl analogue of the scissile peptide bond.	Isoleucine	149-152	renin	Homo sapiens	94-99
3026439-1	1986	Proline-71, an evolutionally conserved residue that separates two short alpha-helical regions, is replaced by valine, threonine, or isoleucine in at least partially functional forms of iso-1-cytochrome c from Saccharomyces cerevisiae [Ernst, J. F., Hampsey, D. M., Stewart, J. W., Rackovsky, S., Goldstein, D., &amp; Sherman, F. (1985) J. Biol.	Isoleucine	132-142	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	185-190
3782093-7	1986	Glu56-Asp-Asp-Asp-Tyr(SO4)-Leu-Asp62 Glu69-Asp-Asp-Asp-Tyr(SO4)-Ile-Asp75 Sulfate-labeled heparin cofactor II formed a covalent complex with thrombin in a heparin-dependent manner.	Isoleucine	64-67	coagulation factor II, thrombin	Homo sapiens	141-149
3026440-1	1986	Proline-71, an evolutionally conserved residue that separates two short alpha-helical regions, is replaced by valine, threonine, or isoleucine in at least partially functional forms of iso-1-cytochrome c from Saccharomyces cerevisiae [Ernst, J. F., Hampsey, D. M., Stewart, J. W., Rackovsky, S., Goldstein, D., &amp; Sherman, F. (1985) J. Biol.	Isoleucine	132-142	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	185-190
3095115-7	1986	Like human apo A-I, rabbit apo A-I contains very little histidine (2) and methionine (1); it does however have two residues of isoleucine.	Isoleucine	127-137	apolipoprotein A-I	Oryctolagus cuniculus	27-34
3530612-3	1986	Myotonic dystrophy patients showed a slower, less marked decline in the serum concentration of insulin sensitive amino acids (threonine, valine, leucine, isoleucine, tyrosine, phenylalanine) during all three insulin infusions compared with normals.	Isoleucine	154-164	insulin	Homo sapiens	95-102
3020546-5	1986	Peptide NH2-terminal histidine, COOH-terminal isoleucine, which has greater than 50% sequence homology of VIP, stimulated the synthesis of both proteins at approximately 50% of VIP effectiveness.	Isoleucine	46-56	vasoactive intestinal peptide	Rattus norvegicus	177-180
3536894-4	1986	The complete prorenin sequence was then excised from the renatured hybrid protein using blood coagulation factor Xa, a proteinase which is highly specific for the tetrapeptide insert Ile-Glu-Gly-Arg introduced between the 9 amino-terminal residues of the trp E gene product and the first amino acid (Thr 1) of prorenin.	Isoleucine	183-186	coagulation factor X	Homo sapiens	106-115
3729426-1	1986	1H-NMR spectra for the angiotensin agonist sarcosine-(Sar)Arg-Val-Tyr-Ile-His-Sar-Phe [( Sar1,Sar7]Ang II) and the antagonist Sar-Arg-Val-Tyr-Ile-His-Sar-Ile in dimethylsulfoxide-d6 were examined at 400 MHz.	Isoleucine	70-73	secretion associated Ras related GTPase 1A	Homo sapiens	89-105
3086996-5	1986	Insulin also significantly reduced the efflux of isoleucine, tyrosine, phenylalanine, glutamine, and total amino acid nitrogen from forearm muscle.	Isoleucine	49-59	insulin	Homo sapiens	0-7
2423506-7	1986	The amino acid sequence from the amino terminus of the 42,000-dalton fragment is Asp/Gly-Gln/Val-?-Ile-Val-, which is almost identical to the sequence Asp-Gln-Cys-Ile-Val- located in the carboxyl terminal 1/3 of the collagen-binding domain of human fibronectin (Kornblihtt et al.	Isoleucine	99-102	fibronectin 1	Homo sapiens	249-260
2423506-7	1986	The amino acid sequence from the amino terminus of the 42,000-dalton fragment is Asp/Gly-Gln/Val-?-Ile-Val-, which is almost identical to the sequence Asp-Gln-Cys-Ile-Val- located in the carboxyl terminal 1/3 of the collagen-binding domain of human fibronectin (Kornblihtt et al.	Isoleucine	163-166	fibronectin 1	Homo sapiens	249-260
3792312-1	1986	Starvation of the mouse hepatoma cell line Hepa for an essential amino acid (Trp, His, Leu, Ile or Phe) stimulated the incorporation of [3H]adenosine as ADP-ribose monomer into an 80,000-Mr protein, P80.	Isoleucine	92-95	coilin	Mus musculus	199-202
3020546-5	1986	Peptide NH2-terminal histidine, COOH-terminal isoleucine, which has greater than 50% sequence homology of VIP, stimulated the synthesis of both proteins at approximately 50% of VIP effectiveness.	Isoleucine	46-56	vasoactive intestinal peptide	Rattus norvegicus	106-109
3015948-3	1986	261, 2697-2711), using a three-fragment complex (1-25)H X (28-38) X (39-104) of horse cytochrome c, have shown that invariant leucine 32 and partially invariant leucine 35, both buried in the interior, exhibit a striking difference in perturbation of binding fragment (28-38) by substitution with isoleucine.	Isoleucine	297-307	cytochrome c, somatic	Equus caballus	86-98
3014910-5	1986	The two hormones differ only in the third amino acid (Phe-3 in AVP is a substitution for Ile-3 in AVT).	Isoleucine	89-92	dihydrolipoamide dehydrogenase	Homo sapiens	54-59
3098237-0	1986	The W and L allelic forms of phenylalanine hydroxylase in the rat differ by a threonine to isoleucine substitution.	Isoleucine	91-101	phenylalanine hydroxylase	Rattus norvegicus	29-54
3521732-9	1986	Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond.	Isoleucine	105-108	kallikrein B1	Homo sapiens	0-20
3002458-1	1986	A monoclonal antibody has been produced to an antigenic site on human cytochrome c which includes amino acid number 58 (isoleucine).	Isoleucine	120-130	cytochrome c, somatic	Homo sapiens	70-82
4093448-5	1985	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and subsequent fluorography for the products of prothrombin activation by staphylocoagulase in the presence of [3H]diisopropylphosphofluoridate (DFP) demonstrated the formation of a DFP-sensitive active site in the prothrombin molecule, and no cleavage of the Arg-Ile bond linking the A and B chains of alpha-thrombin was found.	Isoleucine	322-325	coagulation factor II, thrombin	Homo sapiens	106-117
3510558-8	1986	For isoleucine and proline, the insulin levels required for a half-maximal response were less than for glucose disposal (P less than 0.05), but, for all other insulin-influenced AA, the levels required were similar to those for glucose disposal.	Isoleucine	4-14	insulin	Homo sapiens	32-39
4093448-5	1985	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and subsequent fluorography for the products of prothrombin activation by staphylocoagulase in the presence of [3H]diisopropylphosphofluoridate (DFP) demonstrated the formation of a DFP-sensitive active site in the prothrombin molecule, and no cleavage of the Arg-Ile bond linking the A and B chains of alpha-thrombin was found.	Isoleucine	322-325	coagulation factor II, thrombin	Homo sapiens	109-117
3928488-1	1985	Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action.	Isoleucine	98-101	renin	Rattus norvegicus	14-19
2997158-4	1985	Specific activities of the altered iso-1-cytochromes c were estimated in vivo by growth of the strains in lactate medium; compared to normal iso-1-cytochrome c with Pro-76, the following activities were associated with the following replacements: approximately 90% for Val-76, approximately 60% for Thr-76, approximately 30% for Ser-76, approximately 20% for Ile-76, and 0% for Leu-76.	Isoleucine	359-362	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	35-40
2931434-10	1985	In addition, firm evidence was found that upon activation by plasmin single-chain pro-urokinase is cleaved at the Lys-Ile bond between residues 158 and 159, resulting in the formation of a two-chain urokinase molecule held together by one disulfide linkage.	Isoleucine	118-121	plasminogen	Homo sapiens	61-68
3894123-2	1985	While insulin treatment restores plasma AA pattern, proline, methionine, valine, isoleucine, and total BCAA remain elevated in skeletal muscle intracellular water.	Isoleucine	81-91	insulin	Homo sapiens	6-13
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	103-106	renin	Homo sapiens	0-5
3923107-4	1985	Isoleucine and leucine residues present at positions 28 and 95, respectively, in the B10.BR A beta subunit are not found in the corresponding positions in W12A A beta subunits.	Isoleucine	0-10	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	85-88
3923107-4	1985	Isoleucine and leucine residues present at positions 28 and 95, respectively, in the B10.BR A beta subunit are not found in the corresponding positions in W12A A beta subunits.	Isoleucine	0-10	amyloid beta precursor protein	Homo sapiens	92-98
2985590-4	1985	Our results and the results from the literature search suggest that the aminopeptidase cleaves amino-terminal methionine when it precedes residues of alanine, glycine, proline, serine, threonine, and valine but not when it precedes residues of arginine, asparagine, aspartic acid, glutamine glutamic acid, isoleucine, leucine, lysine, or methionine.	Isoleucine	306-316	aminopeptidase	Saccharomyces cerevisiae S288C	72-86
6386048-4	1984	We conclude that an aromatic ring at position A19 and the presence of the side chain of isoleucine at position A2 are each of critical importance for high biological activity in insulin.	Isoleucine	88-98	insulin	Homo sapiens	178-185
6433495-7	1984	Plasma leucine, isoleucine and valine concentrations were also significantly increased with administration of the BCAA enriched solution, whereas plasma levels of glycine, tyrosine and phenylalanine were significantly reduced.	Isoleucine	16-26	AT-rich interaction domain 4B	Homo sapiens	114-118
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Isoleucine	48-51	angiotensinogen	Homo sapiens	153-168
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Isoleucine	48-51	renin	Homo sapiens	311-316
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Isoleucine	76-79	angiotensinogen	Homo sapiens	153-168
3893430-3	1985	The protein was found to be identical to beta 2-microglobulin, with regard to its molecular weight of 11,000, amino acid composition and 16 amino-terminal amino acids: Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-.	Isoleucine	168-171	beta-2-microglobulin	Homo sapiens	41-61
2582148-8	1985	However, processing of the viral polyprotein Pre65gag into p30 was blocked in the Gln-Ile-deprived cells.	Isoleucine	86-89	centromere protein V	Homo sapiens	59-62
2981722-4	1985	N-terminal sequence analysis of peptide CP2bRA4SP9 established that C1r activation involves the cleavage of a single Arg-Ile bond, located in the sequence: ... Gln-Arg-Gln-Arg-Ile-Ile-Gly-Gly ... .	Isoleucine	121-124	complement C1r	Homo sapiens	68-71
3832701-2	1985	Polyacrylamide gel electrophoresis showed that intermediates and the final product, thrombin, of Mr in the range 21 500-52 000 were present in the incubation mixture Serine and isoleucine were found to be the N-terminal amino acids of the intermediate form 1 and thrombin, respectively.	Isoleucine	177-187	coagulation factor II, thrombin	Homo sapiens	84-92
6496943-1	1984	The chemical shifts of the isoleucine and histidine protons of angiotensin I were assigned and the chemical shifts of the protons of the other amino acids in the peptide were confirmed at a field strength of 400 MHz.	Isoleucine	27-37	angiotensinogen	Homo sapiens	63-76
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	103-106	renin	Homo sapiens	33-38
6385771-1	1984	A synthetic tetradecapeptide, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, which corresponds to the 13 amino terminal residues of human angiotensinogen plus a carboxy terminal serine to replace a suggested site of carbohydrate attachment, has been shown to be a good substrate for human kidney renin.	Isoleucine	76-79	renin	Homo sapiens	311-316
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	103-106	angiotensinogen	Homo sapiens	68-83
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	103-106	renin	Homo sapiens	161-166
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	103-106	cathepsin D	Homo sapiens	196-207
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	131-134	renin	Homo sapiens	0-5
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	131-134	renin	Homo sapiens	33-38
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	131-134	angiotensinogen	Homo sapiens	68-83
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	131-134	renin	Homo sapiens	161-166
6385771-0	1984	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen, H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH, that is human renin specific and is resistant to cathepsin D.	Isoleucine	131-134	cathepsin D	Homo sapiens	196-207
6327184-6	1984	The purified trypsin-activated fibroblast collagenase hydrolyzed type I collagen fibrils, cleaved tropocollagen in solution at 24 degrees C into TCA and TCB fragments, and cleaved the synthetic peptide substrate, DNP-peptide III, at the Gly-Ile bond.	Isoleucine	241-244	matrix metallopeptidase 1	Homo sapiens	31-53
6372857-6	1984	We conclude that the presence of the side chain of isoleucine at position A2 is a critical requirement for high biological activity in insulin.	Isoleucine	51-61	insulin	Bos taurus	135-142
6717443-5	1984	Comparison of this sequence with those of other H-2 class I molecules revealed that: (1) Lys-19, Val-55, Glu-56, Asn-63 and Ile-73 are unique to the H-2Kk molecule; and (2) H-2Kk shares 79-83% homology in this region with other mouse class I molecules.	Isoleucine	124-127	histocompatibility 2, K1, K region	Mus musculus	149-154
6341516-10	1983	Insulin treatment of the alloxanized bovine maintained normal plasma concentrations of valine, isoleucine and leucine.	Isoleucine	95-105	insulin	Bos taurus	0-7
6692367-5	1984	Exposure of exponentially growing cells to isoleucine-deficient medium resulted in decreased thymidine incorporation and disappearance of detectable cellular ER activity.	Isoleucine	43-53	estrogen receptor 1	Homo sapiens	158-160
6692367-7	1984	At 24 hr after release from isoleucine deprivation, ER levels are fully restored, although thymidine incorporation does not resume for an additional 6 to 8 hr, and increases in cell number are not seen for 24 hr.	Isoleucine	28-38	estrogen receptor 1	Homo sapiens	52-54
6693983-5	1984	Plasma insulin was slightly reduced by leucine and by isoleucine and valine.	Isoleucine	54-64	insulin	Gallus gallus	7-14
6316328-8	1983	In the first and the third domains, there is a common sequence of nine residues, Glu (or Asp)-Asn-Asn-Thr-Ile-Ser-Ser-Val-Lys, which is highly homologous to one of the proposed Ca2+-binding sequences in bovine brain calmodulin, Asp-Gly-Asn-Gly-Thr-Ile-Thr-Thr-Lys.	Isoleucine	106-109	calmodulin	Bos taurus	216-226
6646125-1	1983	We have studied the metabolism of dihydrofolate reductase (DHFR) RNA in cells synchronized in the G1 phase of the cell cycle by starvation for isoleucine and glutamine.	Isoleucine	143-153	dihydrofolate reductase	Mus musculus	34-57
6646125-1	1983	We have studied the metabolism of dihydrofolate reductase (DHFR) RNA in cells synchronized in the G1 phase of the cell cycle by starvation for isoleucine and glutamine.	Isoleucine	143-153	dihydrofolate reductase	Mus musculus	59-63
6359978-8	1983	Isoleucine and valine showed a negative correlation with insulin.	Isoleucine	0-10	insulin	Canis lupus familiaris	57-64
6312971-7	1983	The protein--protein-interaction region was found to encompass the region of the surface of horse cytochrome c that includes Ile-81, Phe-82, Ala-83 and Ile-85, and Lys-13 and Lys-72 of horse cytochrome c were suggested to be involved in two important intermolecular interactions.	Isoleucine	125-128	cytochrome c, somatic	Equus caballus	98-110
6312971-7	1983	The protein--protein-interaction region was found to encompass the region of the surface of horse cytochrome c that includes Ile-81, Phe-82, Ala-83 and Ile-85, and Lys-13 and Lys-72 of horse cytochrome c were suggested to be involved in two important intermolecular interactions.	Isoleucine	125-128	cytochrome c, somatic	Equus caballus	191-203
6312971-7	1983	The protein--protein-interaction region was found to encompass the region of the surface of horse cytochrome c that includes Ile-81, Phe-82, Ala-83 and Ile-85, and Lys-13 and Lys-72 of horse cytochrome c were suggested to be involved in two important intermolecular interactions.	Isoleucine	152-155	cytochrome c, somatic	Equus caballus	98-110
6414885-1	1983	During amino acid sequence studies of carbonic anhydrase (CA) III, purified from a pool of human skeletal muscles, and electrophoretically undetectable (silent) variation was found at residue 31 which was either valine and/or isoleucine.	Isoleucine	226-236	carbonic anhydrase 3	Homo sapiens	38-65
6349701-2	1983	It was demonstrated that proteinase I which is apparently cathepsin L from bovine spleen brings about rapid inactivation of angiotensin II with a splitting of the Tyr-Ile bond and a formation of two tetrapeptides.	Isoleucine	167-170	procathepsin L	Bos taurus	58-69
7174657-7	1982	This peptide in the rabbit enzyme, -Arg-Ile-Gln-Glu-Glu-Ala-Arg-Cys147-Leu-Val-Glu-Glu-Leu-Arg-, and the corresponding peptides containing Cys152 in P-450b and Cys134 in P-450cam may serve an essential function such as providing the axial thiolate ligand to the heme iron atom.	Isoleucine	40-43	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	149-155
6830337-7	1983	Plasma amino acid profiles showed a significant fall (p less than 0.05) in fasting and intraprandial tyrosine (tyr) and phenylalanine (phe) on Hepatic-Aid, but only intraprandial leucine (leu), isoleucine (ile), and valine (val) were significantly increased (p less than 0.05) on Hepatic-Aid.	Isoleucine	22-25	activation induced cytidine deaminase	Homo sapiens	151-154
6830337-7	1983	Plasma amino acid profiles showed a significant fall (p less than 0.05) in fasting and intraprandial tyrosine (tyr) and phenylalanine (phe) on Hepatic-Aid, but only intraprandial leucine (leu), isoleucine (ile), and valine (val) were significantly increased (p less than 0.05) on Hepatic-Aid.	Isoleucine	22-25	activation induced cytidine deaminase	Homo sapiens	288-291
6830337-8	1983	The ratio leu + ile + val to tyr + phe was significantly increased (p less than 0.05) on Hepatic-Aid.	Isoleucine	16-19	activation induced cytidine deaminase	Homo sapiens	97-100
6188649-7	1983	The salmon PRL had a molecular weight of 23,400 daltons by gel filtration and 22,300 daltons by sodium dodecyl sulfate gel electrophoresis, with a single NH2-terminal residue, isoleucine, and a single COOH-terminal residue, half-cystine.	Isoleucine	176-186	prolactin	Oryctolagus cuniculus	11-14
6848456-5	1983	Both NIF polypeptides contain one cysteine and one methionine, lack isoleucine, tyrosine and phenylalanine, and are rich in histidine and proline.	Isoleucine	68-78	S100 calcium binding protein A9	Homo sapiens	5-8
7138841-3	1982	The binding of ocytocin, vasopressin, and the tripeptide analogue of the N-terminal sequence of ocytocin, Cys(S-Me)-Tyr-Ile-NH2, results in an increase of S020,W and a decrease in both the reduced viscosity and rotational relaxation time of the bis-liganded dimeric species vs. the nonliganded form.	Isoleucine	120-123	arginine vasopressin	Homo sapiens	25-36
7129757-7	1982	spectra of cyclo(D-Tyr(Me)-L-Ile-L-Pip-L-Leu) (1), cyclo(-D-Tyr(Me)-L-Ile-L-Pro-L-Leu-) (4), and Cyl-2 showed a similar pattern.	Isoleucine	29-32	prolactin induced protein	Homo sapiens	35-38
7253051-7	1981	As a result, the ratio of isoleucine to leucine (Ile/Leu) decreased with albumin infusion from 0.47 (no albumin infused) to 0.27 (60 gm albumin/day).	Isoleucine	26-36	albumin	Homo sapiens	73-80
7042346-1	1982	Saccharomyces cerevisiae mutants lacking the anabolic L-threonine deaminase, the ilv1- mutants, have been found to exhibit a normal ability to grow, without auxotrophy towards isoleucine, on L-threonine of L-serine as only nitrogen nutrient.	Isoleucine	176-186	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	81-85
7287622-9	1981	In addition, the survival of starving cells (no growth substrate available) of spirochete MA-2 was prolonged significantly when l-valine, l-isoleucine, and l-leucine were present in starvation media.	Isoleucine	138-150	PNMA family member 2	Homo sapiens	90-94
7253051-7	1981	As a result, the ratio of isoleucine to leucine (Ile/Leu) decreased with albumin infusion from 0.47 (no albumin infused) to 0.27 (60 gm albumin/day).	Isoleucine	49-52	albumin	Homo sapiens	73-80
7007378-8	1981	Automated Edman degradation of liver AGP which had been extracted from the immunoprecipitate with dilute acid and subsequently treated with pyroglutamate aminopeptidase yielded a sequence of proline and isoleucine identical with that in serum AGP.	Isoleucine	203-213	orosomucoid 1	Rattus norvegicus	37-40
7006941-4	1981	Insulin significantly increased th ileal uptake of valine, isoleucine, leucine, tyrosine, threonine, and serine from arterial blood: uptake of these amino acids was approximately doubled 45 min after the end of the insulin infusion.	Isoleucine	59-69	insulin	Canis lupus familiaris	0-7
6905639-3	1980	The amino acid composition and the carbohydrate content of the kallikrein preparation were determined; isoleucine was identified as the only aminoterminal amino acid.	Isoleucine	103-113	kallikrein related peptidase 4	Homo sapiens	63-73
6928653-6	1980	The results indicated that: (i) angiotensin II and [1-sarcosine,8-isoleucine]angiotensin II gave practically identical spectroscopic data; and (ii) N-methylation in either position 4 or position 5 resulted in remarkable changes in the peptide backbone and a severe limitation in rotational freedom of side chains in tyrosine, isoleucine, and histidine residues.	Isoleucine	66-76	angiotensinogen	Homo sapiens	77-91
6997175-2	1980	As expected, the infusion of insulin exhibited significant reduction of the release of glycine, proline, valine, phenylalanine, leucine, threonine and isoleucine.	Isoleucine	151-161	insulin	Homo sapiens	29-36
6997175-3	1980	As insulin, bradykinin lessened the release of 9 amino acids: Glycine, serine, ornithin, valine, leucine, isoleucine and tyrosine.	Isoleucine	106-116	kininogen 1	Homo sapiens	12-22
6769804-2	1980	Male mice fed the control diet and the isoleucine- or valine-limited diets exhibited lower levels of serum IgG than the female mice fed the same diets.	Isoleucine	39-49	immunoglobulin heavy variable V1-62	Mus musculus	107-110
6769804-5	1980	Except for the mice fed the isoleucine-limited diet, serum IgA levels were higher in male and female mice fed the experimental diets than in mice fed the control diet.	Isoleucine	28-38	immunoglobulin heavy constant alpha	Mus musculus	59-62
6769804-7	1980	However, the levels of transferrin found in the peritoneal exudates were lower in mice fed the isoleucine- or lysine-limited diets than in mice fed the control diet.	Isoleucine	95-105	transferrin	Mus musculus	23-34
6244161-4	1980	Comparison of the data with the analogous data for horse ferrocytochrome c reveals that there is a small difference in structure between cytochrome c in its two oxidation states in the region about Ile-57.	Isoleucine	198-201	cytochrome c, somatic	Equus caballus	62-74
383140-7	1979	The results of this kinetic analysis indicated that the affinity of isoleucyl-tRNA synthetase for Mg.ATP was enhanced upon binding of L-isoleucine and vice versa.	Isoleucine	134-146	isoleucyl-tRNA synthetase 1	Homo sapiens	68-93
518916-12	1979	In the region corresponding to residues 20--26 in osteocalcin, a single replacement of valine for isoleucine was found in turkey tendon protein.	Isoleucine	98-108	bone gamma-carboxyglutamate protein	Rattus norvegicus	50-61
490564-1	1979	Analogues of the type [1-sarcosine,7-sarcosine, 8-X]angiotensin II, where X = isoleucine, leucine, alanine, methionine, O-methylthreonine, or DL-alloisoleucine, were synthesized by the solid-phase method and purified by partition chromatography, cation-exchange chromatography, and high-pressure liquid chromatography.	Isoleucine	78-88	angiotensinogen	Rattus norvegicus	52-66
422660-5	1979	Use of combinations of amino acids confirmed that isoleucine has a similar though weaker effect on tsHl and identified an even weaker protection by valine.	Isoleucine	50-60	tumor-suppressor, HELA cell type	Homo sapiens	99-103
218823-2	1979	(1-Sar-8-Ile) AII (500 ng/kg/min) equally inhibited the pressor responses of AII, AIII and (des-1-Asp) AI by 99% (P less than 0.0001) while (7-Ile) AIII (500 ng/kg/min) was without effect.	Isoleucine	9-12	angiotensinogen	Rattus norvegicus	14-17
218823-2	1979	(1-Sar-8-Ile) AII (500 ng/kg/min) equally inhibited the pressor responses of AII, AIII and (des-1-Asp) AI by 99% (P less than 0.0001) while (7-Ile) AIII (500 ng/kg/min) was without effect.	Isoleucine	9-12	angiotensinogen	Rattus norvegicus	77-80
468115-1	1979	An improved synthesis of a fully protected hexadecapeptide Bpoc-Cys(Trt)-Cys-(Trt)-Thr(But)-Ser(But)-Ile-Cys(Trt)-Ser(But)-Leu-Tyr(But)-Gln-Leu-Glu(OBut)-Asn-Tyr(But)-Cys(Trt)-Asn-OBut, which corresponds to the amino acid sequence 71-86 of human proinsulin, is described.	Isoleucine	101-104	insulin	Homo sapiens	246-256
422660-6	1979	The triple combination of leucine, isoleucine and valine was a much more efficient medium supplement and three times normal concentrations of these amino acids supported growth of tsHl at 38.5 degrees C. It is postulated that they are acting at their respective aminoacyl-tRNA synthetases to help stabilize a complex which also contains the mutant leucyl-tRNA synthetase.	Isoleucine	35-45	tumor-suppressor, HELA cell type	Homo sapiens	180-184
422660-6	1979	The triple combination of leucine, isoleucine and valine was a much more efficient medium supplement and three times normal concentrations of these amino acids supported growth of tsHl at 38.5 degrees C. It is postulated that they are acting at their respective aminoacyl-tRNA synthetases to help stabilize a complex which also contains the mutant leucyl-tRNA synthetase.	Isoleucine	35-45	leucyl-tRNA synthetase 1	Homo sapiens	348-370
382729-6	1978	We conclude that the C-terminal amino acid of the myosin heavy chain is leucine rather than isoleucine as suggested earlier.	Isoleucine	92-102	PBV1SPCR2	Oryctolagus cuniculus	50-68
667113-7	1978	The spectral differences between Mg(II) and Ca(II) show that the degree of backbone folding and interactions between a group of hydrophobic residues (one or more Val, Leu, Ile; two or more Phe) are different for the two cations.	Isoleucine	172-175	carbonic anhydrase 2	Oryctolagus cuniculus	44-50
83165-4	1979	A collagenase complex with alpha2-macroglobulin did not hydrolyze collagen fibrils, but digested the synthetic substrates at the Gly-Ile bond.	Isoleucine	133-136	LOW QUALITY PROTEIN: alpha-2-macroglobulin	Oryctolagus cuniculus	27-47
645868-1	1978	[14C]angiotensin II ([14C]AII) was microinjected alone or with excess L-isoleucine (IIe) or L-aspartic acid (Asp) into renal tubules of anesthetized rats.	Isoleucine	84-87	angiotensinogen	Rattus norvegicus	5-19
696476-4	1978	Production of the TPO glycoprotein results from cleavage of a lysinyl-methionine or arginyl-methionine linkage probably found approximately 80--100 residues from the NH2-terminal isoleucine of the PO molecule.	Isoleucine	179-189	thyroid peroxidase	Homo sapiens	18-21
10624-7	1976	But as the concentration and pH of the solution are increased, the methyl regions for valine, leucine, and isoleucine and aromatic regions of the insulin spectra are broadened.	Isoleucine	107-117	insulin	Homo sapiens	146-153
19034-1	1977	The properties of aqueous solutions of synthetic renin substrate tetradecapeptide (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser) were examined through electrometric titrations, infrared and circular dichroism spectroscopy, and spectrofluorometry.	Isoleucine	99-102	renin	Homo sapiens	49-54
321030-2	1977	Kinetic parameters have been determined for the reaction between chymosin (EC 3.4.23.4) and synthetic peptide analogues of the sequence Leu-Ser-Phe-Met-Ala-Ile around the chymosin-sensitive Phe(105)-Met(106) bond of bovine kappa-casein.	Isoleucine	156-159	chymosin	Bos taurus	65-73
321030-2	1977	Kinetic parameters have been determined for the reaction between chymosin (EC 3.4.23.4) and synthetic peptide analogues of the sequence Leu-Ser-Phe-Met-Ala-Ile around the chymosin-sensitive Phe(105)-Met(106) bond of bovine kappa-casein.	Isoleucine	156-159	chymosin	Bos taurus	171-179
321030-2	1977	Kinetic parameters have been determined for the reaction between chymosin (EC 3.4.23.4) and synthetic peptide analogues of the sequence Leu-Ser-Phe-Met-Ala-Ile around the chymosin-sensitive Phe(105)-Met(106) bond of bovine kappa-casein.	Isoleucine	156-159	casein kappa	Bos taurus	223-235
1002996-15	1976	The partial NH2-terminal sequence of C5a was determined as NH2-Thr-Leu-Glx-Lys-Ile-Glx-Glx-Ile-Ala- and direct comparison with the known sequence of human C3a shows little homology.	Isoleucine	79-82	complement C5a receptor 1	Homo sapiens	37-40
861310-4	1977	Generation of esterase activity requires the presence of an enzyme--factor Xa, which splits the 323-324 peptide bond (Arg-Ile) in the molecules of prothrombin and intermediate products of its activation.	Isoleucine	122-125	coagulation factor II, thrombin	Bos taurus	147-158
999941-9	1976	The NH2- terminal amino acids of the BR and the PAS-II proteins were isoleucine and methionine, respectively.	Isoleucine	69-79	peripheral myelin protein 22	Bos taurus	48-54
175837-7	1976	Hen apoA-I differed from its human counterpart by containing isoleucine.	Isoleucine	61-71	apolipoprotein A1	Homo sapiens	4-10
955577-1	1976	Depending on the species, position 5 in angiotensin II is occupied by isoleucine or valine.	Isoleucine	70-80	angiotensinogen	Homo sapiens	40-54
48419-8	1975	The following amino acids were found in CEA: lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, emthionine, isoleucine, leucine, tyrosine, phenylalanine, and cysteine.	Isoleucine	170-180	CEA cell adhesion molecule 3	Homo sapiens	40-43
1200153-7	1975	Insulin, on the other hand, appeared to have a lipogenic effect on adipose tissue and to stimulate directly the uptake of valine, isoleucine, leucine, tyrosine, lysine, and alanine only at extrahepatic sites.	Isoleucine	130-140	LOC105613195	Ovis aries	0-7
239229-5	1975	The Km values for the substrates and cofactor are as follows: 1.66 for leucine; 0.90 for isoleucine; 0.79 for valine; 0.29 mM for alpha-ketoglutarate; and 0.1 muM for pyridoxal phosphate.	Isoleucine	89-99	latexin	Homo sapiens	159-162
1254727-12	1976	Paired studies with Asp-1, Ile-5 AII also demonstrated a consistent reduction in LpA.	Isoleucine	27-30	angiotensinogen	Rattus norvegicus	33-36
1057162-3	1975	The exception is the replacement of Ile-255 at the bottom of the substrate binding pocket of carboxypeptidase A, by aspartic acid in carboxypeptidase B.	Isoleucine	36-39	carboxypeptidase B1	Bos taurus	133-151
4710580-0	1973	pH dependence of the equilibrium constant for the hydrolysis of the Arg 63 -Ile reactive-site peptide bond in soybean trypsin inhibitor (Kunitz).	Isoleucine	76-79	kunitz trypsin protease inhibitor	Glycine max	118-135
5486454-0	1970	Purification of yellow lupin seed tRNA"s specific for isoleucine and some other amino acids.	Isoleucine	54-64	5'-nucleotidase, cytosolic IIIA	Homo sapiens	23-28
5280529-3	1971	The resulting oxytocin structure places the bulky side chains of the leucine and isoleucine residues, as well as the cyclic moiety of the proline residue, at corners of the two beta-turns.	Isoleucine	81-91	oxytocin/neurophysin I prepropeptide	Homo sapiens	14-22
5556033-0	1971	[Kinetic study of inhibition by L-isoleucine of soluble biosynthetic L-threonine dehydratase from pea seedlings].	Isoleucine	32-44	serine dehydratase	Homo sapiens	69-92
11452384-9	1971	It should be noted that hydrophobic amino acids, like isoleucine, valine and proline, are mainly located in the C-terminal ends of all three chain peptides in the fibrinogen molecule.	Isoleucine	54-64	fibrinogen beta chain	Homo sapiens	163-173
5658077-0	1968	Isolation of isoleucine-specific transfer ribonucleic acid from yellow lupin seeds.	Isoleucine	13-23	5'-nucleotidase, cytosolic IIIA	Homo sapiens	71-76
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Isoleucine	73-76	reticulon 4	Rattus norvegicus	93-99
5813342-8	1969	The use of enzymatic casein hydrolysate, oxytocin, or vasopressin rather than ammonia as nitrogen source for growth of strain 23 depressed the incorporation of 2-methylbutyrate into isoleucine.	Isoleucine	182-192	arginine vasopressin	Homo sapiens	54-65
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Isoleucine	73-76	reticulon 4	Rattus norvegicus	182-188
33555537-7	2021	Finally, we predict at the atomic level that essential residues Lys-205, Ile-190, Pro-194 in Nogo-A-Delta20 and EphA4 residues Gln-390, Asn-425, Pro-426 might play critical roles in Nogo-A-Delta20/EphA4 binding via molecular docking.	Isoleucine	73-76	Eph receptor A4	Rattus norvegicus	197-202
33998043-3	2022	The multiple roles of BAG3 are attributed to its functional regions like BAG, Tryptophan-rich (WW), isoleucine-proline-valine-rich (IPV), and proline-rich (PXXP) domains.	Isoleucine	100-110	BAG cochaperone 3	Homo sapiens	22-26
34052967-3	2021	The aim of this study is to investigate whether individual or combined modifying effects of LOX G/A, GSTM1 active/null, GSTT1 active/null and GSTP1 Ile/Val polymorphisms are related to the risk of lung cancer in relation to smoking in the Egyptian population.	Isoleucine	148-151	glutathione S-transferase pi 1	Homo sapiens	142-147
27271042-6	2021	The rs9616915 SNP, which directly affects SHANK3 gene function of splicing regulation and protein structure damage, is a non- synonymous SNP (T&gt;C) that found in exon 6, leads to substitution of Isoleucine to Threonine.	Isoleucine	197-207	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	42-48
34002224-6	2021	We also observed that HLA-DRB1*13 is more than twice as frequent in the modern population, whereas HLA-B alleles encoding an isoleucine at position 80 (I-80+), HLA C*06:02 and HLA-DPB1 alleles encoding histidine at position 9 are half as frequent in the modern population.	Isoleucine	125-135	major histocompatibility complex, class I, B	Homo sapiens	99-104
33636353-2	2021	The first two steps of the BCAA metabolic pathway are common to the three BCAAs (leucine, isoleucine, and valine).	Isoleucine	90-100	AT rich interactive domain 4B (RBP1-like)	Mus musculus	27-31
34001203-1	2021	BACKGROUND: Beta-ketothiolase deficiency (BKTD) is an autosomal recessive disorder caused by biallelic mutation of ACAT1 that affects both isoleucine catabolism and ketolysis.	Isoleucine	139-149	acetyl-CoA acyltransferase 1	Homo sapiens	12-29
34001203-1	2021	BACKGROUND: Beta-ketothiolase deficiency (BKTD) is an autosomal recessive disorder caused by biallelic mutation of ACAT1 that affects both isoleucine catabolism and ketolysis.	Isoleucine	139-149	acetyl-CoA acetyltransferase 1	Homo sapiens	115-120
33887198-3	2021	A low isoleucine diet reprograms liver and adipose metabolism, increasing hepatic insulin sensitivity and ketogenesis and increasing energy expenditure, activating the FGF21-UCP1 axis.	Isoleucine	6-16	fibroblast growth factor 21	Homo sapiens	168-173
33887198-3	2021	A low isoleucine diet reprograms liver and adipose metabolism, increasing hepatic insulin sensitivity and ketogenesis and increasing energy expenditure, activating the FGF21-UCP1 axis.	Isoleucine	6-16	uncoupling protein 1	Homo sapiens	174-178
33692147-7	2021	Two mAbs, OK4F9 and OK4F10, recognize an epitope that is defined by isoleucine (I) at amino acid position 142 that is present on the Indian rhesus macaque Mamu-B*008:01 allotype, which is an allotype known to be associated with elite control of SIV replication.	Isoleucine	68-78	uncharacterized protein LOC700391	Macaca mulatta	155-161
33612434-7	2021	Follicular fluid adropin concentrations were negatively correlated with HOMA-IR, isoleucine and valine in the PCOS group (all P < 0.05).	Isoleucine	81-91	energy homeostasis associated	Homo sapiens	17-24
33928732-1	2021	AIMS: African-American carriers of the transthyretin (TTR) valine-to-isoleucine substitution (V122I) are at increased risk of heart failure, yet many have relatively subtle abnormalities of left ventricular (LV) function.	Isoleucine	69-79	transthyretin	Homo sapiens	39-52
33928732-1	2021	AIMS: African-American carriers of the transthyretin (TTR) valine-to-isoleucine substitution (V122I) are at increased risk of heart failure, yet many have relatively subtle abnormalities of left ventricular (LV) function.	Isoleucine	69-79	transthyretin	Homo sapiens	54-57
33843274-7	2021	Further, gene deletion analysis of ILV1 and CHA1 in H3R72A mutant confirmed that isoleucine is the sole requirement for growth in minimal medium.	Isoleucine	81-91	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	35-39
33843274-7	2021	Further, gene deletion analysis of ILV1 and CHA1 in H3R72A mutant confirmed that isoleucine is the sole requirement for growth in minimal medium.	Isoleucine	81-91	L-serine/L-threonine ammonia-lyase CHA1	Saccharomyces cerevisiae S288C	44-48
33843274-8	2021	Altogether, we have identified that histone H3R72 residue may be crucial for yeast growth in the minimal medium by regulating isoleucine biosynthesis through the Ilv1 enzyme in budding yeast Saccharomyces cerevisiae.	Isoleucine	126-136	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	162-166
33792201-1	2021	HLA-A*11:361:02 has one nucleotide change from HLA-A*11:01:01:01 at nucleotide 486 where Methionine (138) is changed to Isoleucine.	Isoleucine	120-130	major histocompatibility complex, class I, A	Homo sapiens	0-5
33837233-9	2021	The elevated levels of branched chain amino acids (leucine, isoleucine and valine) in intrauterine growth restricted pregnancies were linked with increased insulin resistance.	Isoleucine	60-70	insulin	Homo sapiens	156-163
33792201-1	2021	HLA-A*11:361:02 has one nucleotide change from HLA-A*11:01:01:01 at nucleotide 486 where Methionine (138) is changed to Isoleucine.	Isoleucine	120-130	major histocompatibility complex, class I, A	Homo sapiens	47-52
33854788-6	2021	By associating metabolomics with genomics, a significant correlation (p < 5.0 x 10-8) between eicosatetraenoic acid and the FADS1 (rs174559) gene is observed, and suggestive correlations (p < 5.0 x 10-6) between pipecolinic acid and CHRM3 (rs535514), and leucine/isoleucine and WWOX (rs72487966) are discovered.	Isoleucine	263-273	fatty acid desaturase 1	Homo sapiens	124-129
33841424-5	2021	In addition, flagellin upregulated the amount of other amino acids substrates of ATB0,+, in particular, all the essential amino acids, such as valine, isoleucine, and leucine, along with the non-essential glutamine.	Isoleucine	151-161	solute carrier family 1 member 5	Homo sapiens	81-85
33168985-7	2021	The missense p.(Ile331Ser) affects the tight hydrophobic interactions of the isoleucine by the disruption of the polar side chain of serine, destabilizing the structure of MINPP1.	Isoleucine	77-87	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	172-178
33687897-12	2021	A correlation between Ala allele at TAP2/665 and Ile allele at TAP2/379 polymorphisms and pathogenesis of SLE was observed.	Isoleucine	49-52	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	36-44
33342963-4	2021	Previously, we reported a Pomeranian dog family with hereditary methemoglobinemia, carrying CYB5R3 mutation of an A>C transition at codon 194 in exon 7, replacing an isoleucine residue with leucine (p.Ile194Leu).	Isoleucine	166-176	cytochrome b5 reductase 3	Canis lupus familiaris	92-98
33422385-11	2021	Caspase1 correlated positively with Isoleucine, GABA, Carnitine, and PC34:2.	Isoleucine	36-46	caspase 1	Homo sapiens	0-8
33268007-0	2021	5-Aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety as potential PTP1B inhibitors.	Isoleucine	53-63	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	102-107
33422385-12	2021	CONCLUSION: We make the novel observation that the NLRP3 inflammasome activity is correlated with certain metabolites (Isoleucine, GABA, Carnitine and PC34:2) and hypothesize that they could trigger increased NLRP3 Inflammasome activity in MetS.	Isoleucine	119-129	NLR family pyrin domain containing 3	Homo sapiens	51-56
33422385-12	2021	CONCLUSION: We make the novel observation that the NLRP3 inflammasome activity is correlated with certain metabolites (Isoleucine, GABA, Carnitine and PC34:2) and hypothesize that they could trigger increased NLRP3 Inflammasome activity in MetS.	Isoleucine	119-129	NLR family pyrin domain containing 3	Homo sapiens	209-214
33617140-11	2021	The missense mutation in eto1-5 generates a substitution of phenylalanine with an isoleucine in ETO1F466I that impairs its dimerization and interaction with EOLs but does not affect binding to CUL3 or ACS5.	Isoleucine	82-92	tetratricopeptide repeat (TPR)-containing protein	Arabidopsis thaliana	25-31
32812692-4	2021	Here, extensive molecular dynamics simulations and interaction network analysis reveal that the 49th isoleucine is a crucial residue that allosterically regulates the dynamics between the FMN and NADP(H) binding domains.	Isoleucine	101-111	formin 1	Homo sapiens	188-191
33541836-8	2021	The reduction in fasting valine and isoleucine may contribute to the longer-term benefits of walnuts on insulin resistance, cardiovascular risk and mortality, whereas the increase in postabsorptive profiles with walnuts may influence food preference.	Isoleucine	36-46	insulin	Homo sapiens	104-111
33455768-14	2021	Catabolism of Lys and Met only increased with MKH alone, resulting in decreased efficiency for milk protein, which demonstrated that Ile and Leu infusion can spare Lys and Met for milk protein synthesis.	Isoleucine	133-136	casein beta	Bos taurus	95-107
33455768-14	2021	Catabolism of Lys and Met only increased with MKH alone, resulting in decreased efficiency for milk protein, which demonstrated that Ile and Leu infusion can spare Lys and Met for milk protein synthesis.	Isoleucine	133-136	casein beta	Bos taurus	180-192
33394222-2	2021	Ca2+/calmodulin (CaM) binds to VGSC type II (NaV1.2) isoleucine and glutamine (IQ) motif.	Isoleucine	53-63	calmodulin 1	Homo sapiens	0-15
33394222-2	2021	Ca2+/calmodulin (CaM) binds to VGSC type II (NaV1.2) isoleucine and glutamine (IQ) motif.	Isoleucine	53-63	calmodulin 1	Homo sapiens	17-20
33394222-2	2021	Ca2+/calmodulin (CaM) binds to VGSC type II (NaV1.2) isoleucine and glutamine (IQ) motif.	Isoleucine	53-63	sodium voltage-gated channel alpha subunit 2	Homo sapiens	45-51
33369793-17	2021	The findings of our study suggest that milk casein hydrolysate enhances glucose uptake by activating insulin-independent AMP-activated protein kinase signaling in skeletal muscle cells, which might be mediated by a milk casein hydrolysate-derived peptide, namely, isoleucine-proline-proline.	Isoleucine	264-274	insulin	Homo sapiens	101-108
33211259-6	2021	Mutation of isoleucine I202 to glutamine (I202Q) or alanine (I202A) significantly reduced both constitutive and induced KIM-1 shedding and ultimately efferocytosis.	Isoleucine	12-22	hepatitis A virus cellular receptor 1	Mus musculus	120-125
33196720-4	2021	The amino acids present in HDACi influenced the HDAC isozyme that could be inhibited most effectively; the l-phenylalanine derivative 4e inhibited the HDAC6 isozyme most potently (IC50 ~ 88 nM), while the l-isoleucine derivative 4h was most effective against the isozyme HDAC2 (IC50 ~ 94 nM).	Isoleucine	205-217	histone deacetylase 6	Homo sapiens	151-156
33995927-3	2021	Meanwhile, rs9616915 is a non-synonymous SNP (T>C) located in the exon 6 of the SHANK3 gene, which induces substitution of isoleucine to threonine and affects the function of the resulted protein.	Isoleucine	123-133	SH3 and multiple ankyrin repeat domains 3	Homo sapiens	80-86
33268007-1	2021	Two series of 5-aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety were identified as competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors.	Isoleucine	67-77	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	134-165
33268007-1	2021	Two series of 5-aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety were identified as competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors.	Isoleucine	67-77	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	167-172
33310174-1	2021	AIMS: In healthy individuals, intragastric administration of the branched-chain amino acids, leucine and isoleucine, diminishes the glycaemic response to a mixed-nutrient drink, apparently by stimulating insulin and slowing gastric emptying, respectively.	Isoleucine	105-115	insulin	Homo sapiens	204-211
33310174-6	2021	RESULTS: Leucine and isoleucine stimulated insulin, both before and after the drink (all P<0.05; peak (mU/L): control: 70+-15; leucine: 88+-17; isoleucine: 74+-15).	Isoleucine	21-31	insulin	Homo sapiens	43-50
33310174-7	2021	Isoleucine stimulated (P<0.05), and leucine tended to stimulate (P=0.078), glucagon before the drink, and isoleucine stimulated glucagon post-drink (P=0.031; peak (pg/mL): control: 62+-5; leucine: 70+-9; isoleucine: 69+-6).	Isoleucine	106-116	glucagon	Homo sapiens	128-136
33505124-3	2021	A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity.	Isoleucine	109-119	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	67-71
33186626-3	2021	However, due to a single amino acid substitution of valine to isoleucine in mouse CRBN at position 391, mice are not susceptible to IMiD-induced degradation of neo-substrates.	Isoleucine	62-72	cereblon	Mus musculus	82-86
33505124-3	2021	A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity.	Isoleucine	109-119	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	144-148
33288780-4	2020	Here we report using our QTY (glutamine, threonine, tyrosine) code to systematically replace 29 membrane-facing leucine, isoleucine, valine, and phenylalanine residues in the transmembrane alpha-helices of the GPCR CXCR4.	Isoleucine	121-131	C-X-C motif chemokine receptor 4	Homo sapiens	215-220
33396864-2	2020	The most frequent HBc variant in chronic hepatitis B patients is mutant 97L, changing from an isoleucine or phenylalanine to a leucine (L) at HBc amino acid 97.	Isoleucine	94-104	keratin 88, pseudogene	Homo sapiens	18-21
33396864-2	2020	The most frequent HBc variant in chronic hepatitis B patients is mutant 97L, changing from an isoleucine or phenylalanine to a leucine (L) at HBc amino acid 97.	Isoleucine	94-104	keratin 88, pseudogene	Homo sapiens	142-145
33332443-9	2020	Single Nucleotide Polymorphism (SNP, rs324981) Asn107Ile of NPSR1gene, that switches an amino acid from Asn to Ile, has been found associated with increased susceptibility to obesity in Pakistani individuals.	Isoleucine	53-56	neuropeptide S receptor 1	Homo sapiens	60-65
33222863-12	2020	The individual AA Leu, Met, Ile, and Arg increased S6K1 phosphorylation in an insulin-dependent manner.	Isoleucine	28-31	ribosomal protein S6 kinase B1	Bos taurus	51-55
33222863-18	2020	In addition, the AA responsible for the bulk of mTORC1 activation in MAC-T are limited to Leu, Met, Ile, Arg, and Thr.	Isoleucine	100-103	CREB regulated transcription coactivator 1	Mus musculus	48-54
33222863-12	2020	The individual AA Leu, Met, Ile, and Arg increased S6K1 phosphorylation in an insulin-dependent manner.	Isoleucine	28-31	insulin	Bos taurus	78-85
33294441-7	2020	Results: By postsequencing bioinformatic analyses and Sanger sequencing, we identified a novel missense variant (NM_003722.4:c.948G>A; p.Met316Ile) of TP63 in this family that results in a substitution of methionine with isoleucine, which is probably associated with the occurrence of SHFM.	Isoleucine	221-231	tumor protein p63	Homo sapiens	151-155
32939586-7	2020	The missense (c.3328A > G) variant, inherited from his mother, leads to the replacement of isoleucine by valine at the position of 1110 (p.Ile1110Val) of the ABCA5 protein.	Isoleucine	91-101	ATP binding cassette subfamily A member 5	Homo sapiens	158-163
33000234-5	2020	Gene sequencing analysis showed that the c.1514T>C homozygous mutation in the region of the 12th exon of the ETFDH gene, which led to the amino acid substitution p.I505T (isoleucine > threonine), resulting in defective ETFDH protein function.	Isoleucine	171-181	electron transfer flavoprotein dehydrogenase	Homo sapiens	109-114
33255380-4	2020	Induction was severely compromised in plants lacking the JA-Ile receptor CORONATINE INSENSITIVE 1 or enzymes required for JA-Ile biosynthesis.	Isoleucine	60-63	RNI-like superfamily protein	Arabidopsis thaliana	73-97
33000234-5	2020	Gene sequencing analysis showed that the c.1514T>C homozygous mutation in the region of the 12th exon of the ETFDH gene, which led to the amino acid substitution p.I505T (isoleucine > threonine), resulting in defective ETFDH protein function.	Isoleucine	171-181	electron transfer flavoprotein dehydrogenase	Homo sapiens	219-224
32378356-6	2020	Bioinformatics analysis indicated the change in amino acid from Ile to Leu may affect the function of the MTNR1B protein by impacting the secondary and tertiary protein structures.	Isoleucine	64-67	melatonin receptor type 1B	Ovis aries	106-112
33209309-0	2020	Structural details of the enzymatic catalysis of carbonic anhydrase II via a mutation of valine to isoleucine.	Isoleucine	99-109	carbonic anhydrase 2	Homo sapiens	49-70
33142512-7	2020	High Leu levels increased (P < 0.05) mRNA expression of S6K1 and eEF2 genes only in birds fed high Ile levels.	Isoleucine	99-102	eukaryotic translation elongation factor 2	Gallus gallus	65-69
33142512-9	2020	Higher Val and Ile levels are required to optimize the effect of Leu supplementation on mRNA expression of mTOR pathway genes in the pectoralis major muscle of broilers from day 1 to 21 after hatch.	Isoleucine	15-18	mechanistic target of rapamycin	Gallus gallus	107-111
33096658-6	2020	Specific AAs (i.e., leucine and isoleucine) co-ingested with glucose exerted a synergistic effect on the postprandial insulin response and attenuated the glucose response compared to glucose intake alone in healthy participants.	Isoleucine	32-42	insulin	Homo sapiens	118-125
32776205-1	2020	In the yeast Saccharomyces cerevisiae, the mitochondrial branched-chain amino acid (BCAA) aminotransferase Bat1 plays an important role in the synthesis of BCAAs (valine, leucine, and isoleucine).	Isoleucine	184-194	branched-chain-amino-acid transaminase BAT1	Saccharomyces cerevisiae S288C	107-111
33081246-7	2020	Upon the evaluation of the inhibitory potency of the newly obtained analogues, nanomolar inhibitory activities were noted for the leucine and isoleucine analogues targeting class I aaRS enzymes, while rather weak inhibitory activity against the corresponding class II aaRSs was observed.	Isoleucine	142-152	alanyl-tRNA synthetase 1	Homo sapiens	181-185
33117613-5	2020	Among all Vpu variants, three of the variants having serine substitution (serine-52 and serine-56 conversion to isoleucine; S52I and S56I) had lost their functional beta-TrcP binding motif.	Isoleucine	112-122	Vpu	Human immunodeficiency virus 1	10-13
32924442-0	2020	Reversible oligomerization and reverse hydrophobic effect induced by isoleucine tags attached at the C-terminus of a simplified BPTI variant.	Isoleucine	69-79	spleen trypsin inhibitor I	Bos taurus	128-132
33023275-1	2020	Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates.	Isoleucine	9-19	AT-rich interaction domain 4B	Homo sapiens	70-74
32725697-1	2020	HLA-A*02:411 differs from HLA-A*02:01:01:01 at nucleotides 770 and 771 where Threonine (T) replaces Isoleucine (I) at residue 233.	Isoleucine	100-110	major histocompatibility complex, class I, A	Homo sapiens	0-5
32725697-1	2020	HLA-A*02:411 differs from HLA-A*02:01:01:01 at nucleotides 770 and 771 where Threonine (T) replaces Isoleucine (I) at residue 233.	Isoleucine	100-110	major histocompatibility complex, class I, A	Homo sapiens	26-31
32737198-3	2020	To answer this question, we performed a comprehensive 13C-methyl relaxation study of Ile, Leu, and Val (ILV) residues of PTP1B, which, because of its substantially increased sensitivity, provides a comprehensive understanding of the influence of protein motions on different time scales for enzyme function.	Isoleucine	85-88	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	121-126
32960988-1	2021	BACKGROUND: Branched-chain amino acids (BCAA: leucine, isoleucine, and valine) are essential amino acids involved in biological functions of brain development and recently linked with autism.	Isoleucine	55-65	AT-rich interaction domain 4B	Homo sapiens	40-44
32912085-9	2022	MD simulation also showed that alanine at N-terminal of Smac could be replaced with isoleucine without alternation of biological activity which was in agreement with in vitro experiments.	Isoleucine	84-94	diablo IAP-binding mitochondrial protein	Homo sapiens	56-60
32973838-5	2020	Here, we showed that the substitution of arginine with isoleucine in the FRNK motif at position 184 of helper component-proteinase (HC-Pro) abolished its RNA silencing suppression (RSS) activity, drastically reduced the virulence and accumulation level of SCMV, and impaired the synergism between SCMV and maize chlorotic mottle virus.	Isoleucine	55-65	protein tyrosine kinase 2	Homo sapiens	73-77
31493294-9	2020	Sequencing of the entire COCH gene coding region from the patient"s blood revealed a novel variant resulting in a non-conservative amino acid substitution of isoleucine to phenylalanine (c.1621A&gt;T, p.I541F) in the vWFA2 domain at the protein"s C-terminus.	Isoleucine	158-168	cochlin	Homo sapiens	25-29
32589920-0	2020	The structure of the Drosophila melanogaster sex peptide: Identification of hydroxylated isoleucine and a strain variation in the pattern of amino acid hydroxylation.	Isoleucine	89-99	Sex Peptide	Drosophila melanogaster	45-56
32589920-4	2020	The SP gene predicts an isoleucine (Ile14) sandwiched between two of the hydroxyprolines of the mature secreted peptide, but the identity of this residue was not established by peptide sequencing and amino acid analysis, presumably because of modification of the side chain.	Isoleucine	24-34	Sex Peptide	Drosophila melanogaster	4-6
32833997-10	2020	In contrast, Cryab-R120G knock-in lenses exhibited increased total amino acid content including valine, alanine, serine, leucine, isoleucine, glycine, and aspartic acid.	Isoleucine	130-140	crystallin, alpha B	Mus musculus	13-18
32692195-7	2020	SLC12A3 gene analysis in mother and two babies revealed heterozygous mutations at 988 ATA codon in exon 26, which convert isoleucine to threonine (I988T).	Isoleucine	122-132	solute carrier family 12 member 3	Homo sapiens	0-7
32731373-4	2020	Using (2s,3r,4s)-4-hydroxyisoleucine (4-HIL) as a model product, we coupled regio- and stereo-selective hydroxylation of l-Ile by the dioxygenase IDO with 2-KG generation from readily available l-Glu by l-glutamate oxidase (LGOX) and catalase (CAT).	Isoleucine	121-126	indoleamine 2,3-dioxygenase 1	Homo sapiens	146-149
32731373-4	2020	Using (2s,3r,4s)-4-hydroxyisoleucine (4-HIL) as a model product, we coupled regio- and stereo-selective hydroxylation of l-Ile by the dioxygenase IDO with 2-KG generation from readily available l-Glu by l-glutamate oxidase (LGOX) and catalase (CAT).	Isoleucine	121-126	catalase	Homo sapiens	234-242
32731373-4	2020	Using (2s,3r,4s)-4-hydroxyisoleucine (4-HIL) as a model product, we coupled regio- and stereo-selective hydroxylation of l-Ile by the dioxygenase IDO with 2-KG generation from readily available l-Glu by l-glutamate oxidase (LGOX) and catalase (CAT).	Isoleucine	121-126	catalase	Homo sapiens	244-247
32423671-0	2020	Exploration of dipeptidyl-peptidase IV (DPP IV) inhibitors in a low-molecular mass extract of the earthworm Eisenia fetida and identification of the inhibitors as amino acids like methionine, leucine, histidine, and isoleucine.	Isoleucine	216-226	dipeptidyl peptidase 4	Homo sapiens	40-46
32859884-7	2020	Plasma levels of leucine, isoleucine, valine, and overall BCAAs were correlated with the activation of mTOR (P < 0.001) and p70S6K (P < 0.001).	Isoleucine	26-36	mechanistic target of rapamycin kinase	Rattus norvegicus	103-107
32859884-7	2020	Plasma levels of leucine, isoleucine, valine, and overall BCAAs were correlated with the activation of mTOR (P < 0.001) and p70S6K (P < 0.001).	Isoleucine	26-36	ribosomal protein S6 kinase B1	Rattus norvegicus	124-130
32580388-0	2020	Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-kappaB Signaling.	Isoleucine	0-10	Ribosomal protein S27A	Drosophila melanogaster	72-81
32580388-0	2020	Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-kappaB Signaling.	Isoleucine	0-10	Relish	Drosophila melanogaster	97-106
32580388-8	2020	In additional studies, we show that toxicity from untethered, linear chains is regulated by isoleucine 44, which anchors a key interaction site for ubiquitin.	Isoleucine	92-102	Ribosomal protein S27A	Drosophila melanogaster	148-157
32510827-7	2020	There were positive associations of daily leucine, isoleucine, and valine intake with the risks for overweight and insulin resistance.	Isoleucine	51-61	insulin	Homo sapiens	115-122
32286421-6	2020	Further, methionine, isoleucine, tryptophan, xanthurenic acid, and indole-3-carboxaldehyde were negatively associated with C-reactive protein (CRP), but 5-hydroxyindole-3-acetic acid was positively associated with CRP.	Isoleucine	21-31	C-reactive protein	Homo sapiens	143-146
32321917-4	2020	Pathway analyses of these proteins using the KEGG database shown that the EGFR-interacting proteins of the cytosol and nucleus are involved in the ribosome and spliceosome pathways, respectively, while those of the mitochondria are involved in metabolizing propanoate, fatty acid, valine, leucine, and isoleucine.	Isoleucine	302-312	epidermal growth factor receptor	Homo sapiens	74-78
32032708-6	2020	In addition, we observed a unique tRNA-Ile-Met-Glu (IMQ) gene order that differed from the tRNA-Glu-Ile-Met (QIM) order previously reported for other 14 Cynoglossinae mitogenomes.	Isoleucine	39-42	hepatocyte growth factor receptor	Cynoglossus semilaevis	43-46
32621420-1	2020	OBJECTIVE: To investigate the effect of calmodulin (CaM) and its mutants on binding to voltage-gated Na channel isoleucine-glutamine domain (NaV1.2 IQ).	Isoleucine	112-122	calmodulin 1	Homo sapiens	40-50
32621420-1	2020	OBJECTIVE: To investigate the effect of calmodulin (CaM) and its mutants on binding to voltage-gated Na channel isoleucine-glutamine domain (NaV1.2 IQ).	Isoleucine	112-122	calmodulin 1	Homo sapiens	52-55
32621420-1	2020	OBJECTIVE: To investigate the effect of calmodulin (CaM) and its mutants on binding to voltage-gated Na channel isoleucine-glutamine domain (NaV1.2 IQ).	Isoleucine	112-122	sodium voltage-gated channel alpha subunit 2	Homo sapiens	141-147
32229156-5	2020	To assess whether L-isoleucine, calcitriol, phenyl butyrate, metformin, glyburide or insulin induced RNase 7, keratinocytes were stimulated, and RNase 7 expression was evaluated.	Isoleucine	18-30	ribonuclease A family member 7	Homo sapiens	101-108
32321430-7	2020	While the jar1-1 mutant lacked jasmonate-isoleucine and jasmonate-leucine, it accumulated 12-oxo-phytodienoic acid at low temperature on agar medium.	Isoleucine	41-51	Auxin-responsive GH3 family protein	Arabidopsis thaliana	10-14
32245218-5	2020	This scaffold mimics the buried amino acid sequence Ile-25` to Arg-28` at the core of NS4A21`-33` needed to activate the NS3 protease.	Isoleucine	52-55	KRAS proto-oncogene, GTPase	Homo sapiens	121-124
32230787-5	2020	Statistically significant higher levels of isoleucine and methionine in their free form were detected in FM samples based on caprine milk, while FM samples based on bovine milk showed a higher level of glucose and galactose in comparison to HBM.	Isoleucine	43-53	Weaning weight-maternal milk	Bos taurus	133-137
32157879-2	2020	A tripeptide, LRW (Leu-Arg-Trp), was characterized from pea protein legumin, and its previously studied isomer IRW (Ile-Arg-Trp) was reported to exhibit antihypertensive activity via activation of angiotensin-converting enzyme 2.	Isoleucine	116-119	angiotensin I converting enzyme 2	Rattus norvegicus	197-228
32219097-8	2020	Interestingly, oral administration of seven essential amino acids (EAAs; valine, leucine, isoleucine, lysine, phenylalanine, histidine, and tryptophan) to LPD mice, which can be a source of neurotransmitters, reversed those behavioral changes.	Isoleucine	90-100	acyl-CoA synthetase bubblegum family member 1	Mus musculus	155-158
32183423-7	2020	CONCLUSIONS: Eight specific amino acids (isoleucine, leucine, lysine, methionine, phenylalanine, proline, tyrosine, and valine) were implicated in the appetite-suppressant and GLP-1-stimulating effects of whey proteins, which may be mediated by their binding with nutrient-sensing receptors expressed by L cells within the gastrointestinal wall.	Isoleucine	41-51	glucagon	Homo sapiens	176-181
31948748-5	2020	The ABCB5/STAT1 high-expressing clones showed higher cellular levels of Ala, Glu, and Asp and lower cellular levels of Phe, Trp, Leu, Ile, Gly, Met, Tyr, Val, and His compared to the ABCB5/STAT1 low-expressing clones.	Isoleucine	134-137	ATP-binding cassette, sub-family B (MDR/TAP), member 5	Mus musculus	4-9
31948748-5	2020	The ABCB5/STAT1 high-expressing clones showed higher cellular levels of Ala, Glu, and Asp and lower cellular levels of Phe, Trp, Leu, Ile, Gly, Met, Tyr, Val, and His compared to the ABCB5/STAT1 low-expressing clones.	Isoleucine	134-137	signal transducer and activator of transcription 1	Homo sapiens	10-15
31960518-7	2020	We also found that enzymes that convert proline, valine, leucine, and isoleucine into glutamate were increased in IDH1 mut glioma.	Isoleucine	70-80	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	114-118
32143681-5	2020	A previously unreported c.454GTAC > G variant produced an inframe deletion of a highly conserved isoleucine residue in Cav3.2 (p.DeltaI153) and caused a complete loss-of-function of the channel, with an additional dominant-negative effect on the wild-type channel when expressed in trans.	Isoleucine	97-107	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	119-125
32046227-2	2020	A major jasmonate is (+)-7-iso-jasmonoyl-l-isoleucine (JA-Ile), which is perceived by the unique COI1-JAZ coreceptor system.	Isoleucine	42-53	zinc finger protein 346	Homo sapiens	102-105
32117393-9	2020	With the chain elongation pathway, CYP79C2 still mainly produced 2-methylpropyl GLS derived from leucine, accompanied by GLSs derived from isoleucine and from chain-elongated mono- and dihomoleucine, but not from phenylalanine.	Isoleucine	139-149	cytochrome p450 79c2	Arabidopsis thaliana	35-42
32184802-9	2020	PLOD1 and SETD7 genes were involved with lysine degradation in low feed efficient group in Landrace, while high feed efficient group pointed to genes underpinning valine, leucine, isoleucine degradation, and fatty acid elongation.	Isoleucine	180-190	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Sus scrofa	0-5
32184802-9	2020	PLOD1 and SETD7 genes were involved with lysine degradation in low feed efficient group in Landrace, while high feed efficient group pointed to genes underpinning valine, leucine, isoleucine degradation, and fatty acid elongation.	Isoleucine	180-190	SET domain containing 7, histone lysine methyltransferase	Sus scrofa	10-15
32117393-6	2020	Co-expression of CYP79C2 with either the aliphatic or aromatic core structure pathways resulted in the production of primarily leucine-derived 2-methylpropyl GLS and phenylalanine-derived benzyl GLS, along with minor amounts of GLSs from isoleucine, tryptophan, and tyrosine.	Isoleucine	238-248	cytochrome p450 79c2	Arabidopsis thaliana	17-24
32117393-7	2020	Co-expression of CYP79C1 displayed minor amounts of GLSs from valine, leucine, isoleucine, and phenylalanine with the aliphatic core structure pathway, and similar GLS profile (except the GLS from valine) with the aromatic core structure pathway.	Isoleucine	79-89	cytochrome P450, family 79, subfamily C, polypeptide 1	Arabidopsis thaliana	17-24
31832774-6	2019	Point mutation of Ile to Phe in cry2 in this position created a novel mutant.	Isoleucine	18-21	cryptochrome 2	Arabidopsis thaliana	32-36
31486189-2	2020	IleRS misactivates nonproteinogenic norvaline (Nva) and proteinogenic valine (Val), with a 200-fold lower efficiency than the cognate isoleucine (Ile).	Isoleucine	134-144	isoleucyl-tRNA synthetase 1	Homo sapiens	0-5
31689951-3	2019	The purpose of this study was to examine how Ile and Leu influence both GLP-1 and GIP, subsequent pancreatic hormones, and glycemia in healthy, inactive adults.	Isoleucine	45-48	glucagon	Homo sapiens	72-77
31654490-2	2019	The diagnosis is usually first suspected on finding elevated isoleucine degradation metabolites in urine, reflecting decreased MHBD activity.	Isoleucine	61-71	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	127-131
31758001-4	2019	Here, we examined at cellular and ultrastructural level oocytes from hyh (hydrocephalus with hop gait) mice, which present a missense mutation in the Napa gene that results in the substitution of methionine for isoleucine at position 105 (M105I) of alpha-SNAP.	Isoleucine	211-221	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	69-72
31758001-4	2019	Here, we examined at cellular and ultrastructural level oocytes from hyh (hydrocephalus with hop gait) mice, which present a missense mutation in the Napa gene that results in the substitution of methionine for isoleucine at position 105 (M105I) of alpha-SNAP.	Isoleucine	211-221	N-ethylmaleimide sensitive fusion protein attachment protein alpha	Mus musculus	150-154
31591185-4	2019	The interaction between RhoB and Arf6 is mediated by the GCI (glycine, cysteine, and isoleucine) residues (188-190) of RhoB.	Isoleucine	85-95	ras homolog family member B	Homo sapiens	24-28
31591185-4	2019	The interaction between RhoB and Arf6 is mediated by the GCI (glycine, cysteine, and isoleucine) residues (188-190) of RhoB.	Isoleucine	85-95	ADP ribosylation factor 6	Homo sapiens	33-37
31591185-4	2019	The interaction between RhoB and Arf6 is mediated by the GCI (glycine, cysteine, and isoleucine) residues (188-190) of RhoB.	Isoleucine	85-95	ras homolog family member B	Homo sapiens	119-123
31689951-3	2019	The purpose of this study was to examine how Ile and Leu influence both GLP-1 and GIP, subsequent pancreatic hormones, and glycemia in healthy, inactive adults.	Isoleucine	45-48	gastric inhibitory polypeptide	Homo sapiens	82-85
31689951-10	2019	The ingestion of Ile prior to CHO augmented GIP concentration greater than Leu or Pla.	Isoleucine	17-20	gastric inhibitory polypeptide	Homo sapiens	44-47
31689951-12	2019	CONCLUSIONS: Ile impacts GIP concentration, which did not relate to either insulin or glucose concentrations.	Isoleucine	13-16	gastric inhibitory polypeptide	Homo sapiens	25-28
31743939-8	2019	The exome sequencing revealed a novel homozygous variant (c.296G>T) in ARL3, which is predicted to substitute an evolutionarily conserved arginine with isoleucine within the encoded protein GTP-binding domain (R99I).	Isoleucine	152-162	ADP ribosylation factor like GTPase 3	Homo sapiens	71-75
31377397-8	2019	Replacement of F28 with other aromatic residues like tyrosine and tryptophan preserves protein stability while replacement with non-aromatic amino acids like leucine, isoleucine, valine or alanine severely affects the stability of SHIP1.	Isoleucine	167-177	inositol polyphosphate-5-phosphatase D	Homo sapiens	231-236
31518373-2	2019	Here we found that the single isoleucine residue I490 in Rj2 is required for induction of symbiotic incompatibility.	Isoleucine	30-40	TIR-NBS-LRR family protein	Glycine max	57-60
30734935-7	2019	Plasma levels were particularly low in patients who received amino acid mixtures (AAMs-OAD) and L-isoleucine:L-leucine:L-valine (BCAA) ratio was 1.0:3.0:3.2.	Isoleucine	96-108	AT-rich interaction domain 4B	Homo sapiens	129-133
31421874-15	2019	Regression analyses indicated that intracellular concentrations of Met, Thr, Ile, and Leu predicted phosphorylation of mTOR-related proteins with adequate precision and accuracy, suggesting that multiple EAA dictate regulation, regardless of AA ratios.	Isoleucine	77-80	mechanistic target of rapamycin kinase	Bos taurus	119-123
31574962-7	2019	The molecular modeling results for analogue 10 showed that the use of the 4-(aminomethyl)benzamide as a flexible linker leads to a favorable overall geometry of the molecule, which allows one to bypass the bulk isoleucine residue and provides the necessary binding to the active center of the T315I-mutant Abl (PDB: 3QRJ).	Isoleucine	211-221	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	306-309
31226655-11	2019	The NF-kappaB inhibitory effect depended on the N-terminal cysteine and the neighboring Arg-Ser-Ala-Gly-Ser-Ile (RSAGSI) domain of NF-kappaB.	Isoleucine	108-111	nuclear factor kappa B subunit 1	Homo sapiens	4-13
31226655-11	2019	The NF-kappaB inhibitory effect depended on the N-terminal cysteine and the neighboring Arg-Ser-Ala-Gly-Ser-Ile (RSAGSI) domain of NF-kappaB.	Isoleucine	108-111	nuclear factor kappa B subunit 1	Homo sapiens	131-140
31228515-2	2019	In addition to this activity, ACAT1 is also involved in isoleucine degradation pathway.	Isoleucine	56-66	acetyl-CoA acetyltransferase 1	Homo sapiens	30-35
31162686-6	2019	Using a buffer containing SDS and beta-CD in CE, a LOD of 0.7 microM of L-Trp can be reached and the ratio of the intensities between Leu, Isoleucine, Valine, Trp is 100, 21, 15, 1.	Isoleucine	139-149	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	34-41
31111503-4	2019	We generated a mouse model in which exchange of a conserved catalytic amino acid residue (isoleucine to valine, Ile170Val) reduces TPI specific activity without affecting the stability of the protein dimer.	Isoleucine	90-100	triosephosphate isomerase 1	Mus musculus	131-134
31361548-1	2019	Branched-chain amino acid (BCAAs: leucine, isoleucine, and valine) contribute to the development of obesity-associated insulin resistance in the context of consumption of a high-fat diet (HFD) in humans and rodents.	Isoleucine	43-53	insulin	Homo sapiens	119-126
31388182-6	2019	Here, we evaluate Igf2r specific loss-of-function of the domain-11 IGF2 binding site by replacing isoleucine with alanine in the CD loop (exon 34, I1565A), a mutation also detected in cancers.	Isoleucine	98-108	insulin like growth factor 2 receptor	Homo sapiens	18-23
31398828-5	2019	The protease side-activities mainly acted on the hydrophobic C-terminus of beta-CN at Ala, Pro, Ile, Phe, Leu, Lys, Gln, and Tyr positions, resulting in the formation of peptides, some of which were N-terminal glycated or potentially bitter.	Isoleucine	96-99	apoptotic chromatin condensation inducer 1	Homo sapiens	75-82
31388182-6	2019	Here, we evaluate Igf2r specific loss-of-function of the domain-11 IGF2 binding site by replacing isoleucine with alanine in the CD loop (exon 34, I1565A), a mutation also detected in cancers.	Isoleucine	98-108	insulin like growth factor 2	Homo sapiens	67-71
31293161-6	2019	For the ZA domain of Arf-GAP ASAP1, with a global correlational time of 24 ns at 15  C, a wide range of conformational dynamics (exhibiting chemical exchange rates (kex) between 102 and 105 s-1) are observed in the methyl groups of isoleucine, leucine, and valine.	Isoleucine	232-242	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	29-34
31098606-7	2019	l-Leucine-, l-isoleucine- or BCAAs mix-induced CCK secretion was significantly decreased after tissues were pretreated with lactisole, a T1R1/T1R3 inhibitor (P &lt; 0.05).	Isoleucine	12-24	cholecystokinin	Homo sapiens	47-50
31223455-0	2019	Modifications at Arg and Ile Give Neurotensin(8-13) Derivatives with High Stability and Retained NTS1 Receptor Affinity.	Isoleucine	25-28	neurotensin	Homo sapiens	97-101
30802707-5	2019	Molecular modeling revealed that the compound 4d binds through hydrophobic-hydrophobic interactions with the essential amino acids (LEU: 57, GLY: 58, ILE: 61, and HIS: 96) in the p53-binding cleft, as a standard p53-MDM2 inhibitor (6SJ).	Isoleucine	150-153	tumor protein p53	Homo sapiens	179-182
30913349-0	2019	Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1-7)/Mas Receptor Axis.	Isoleucine	48-51	angiotensin I converting enzyme 2	Rattus norvegicus	127-131
30913349-0	2019	Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1-7)/Mas Receptor Axis.	Isoleucine	48-51	angiogenin	Rattus norvegicus	132-135
31346205-4	2019	Genotypic differences were observed among PCV2a, 2b, and 2d at amino acid position 89 in ORF2, with isoleucine (I), arginine (R), and leucine (L), respectively.	Isoleucine	100-110	capsid protein	Porcine circovirus 2	89-93
31149689-0	2019	Isoleucine attenuates infection induced by E. coli challenge through the modulation of intestinal endogenous antimicrobial peptide expression and the inhibition of the increase in plasma endotoxin and IL-6 in weaned pigs.	Isoleucine	0-10	interleukin 6	Sus scrofa	201-205
31149689-4	2019	Isoleucine supplementation enhanced the concentrations of total plasma protein and IgA in pigs compared to the alanine control diet, while inhibiting the increase in plasma endotoxin and IL-6 contents induced by E. coli challenge.	Isoleucine	0-10	interleukin 6	Sus scrofa	187-191
31317034-7	2019	High levels of Ile significantly increased the expression of the gamma isoform of 4EBP1 (P < 0.001), which indicated that the phosphorylation of 4EBP1 was significantly increased.	Isoleucine	15-18	4ebp1	None	82-87
31317034-8	2019	The phosphorylation level of eEF2 gradually decreased with the addition of Ile (P < 0.001).	Isoleucine	75-78	eef2	None	29-33
31317034-9	2019	These results suggested that high doses of Ile can regulate the excretion of enzymes, especially alpha-amylase, in the pancreatic tissues of dairy goats by modulating mTOR signalling, and this regulation is independent of the mTOR-S6K1 pathway.	Isoleucine	43-46	mtor	None	167-171
31317034-9	2019	These results suggested that high doses of Ile can regulate the excretion of enzymes, especially alpha-amylase, in the pancreatic tissues of dairy goats by modulating mTOR signalling, and this regulation is independent of the mTOR-S6K1 pathway.	Isoleucine	43-46	s6k1	None	231-235
30830240-12	2019	Several enzymes related to BCAA metabolism were found to exhibit augmented expression in the R6/2 brain, particularly related to isoleucine metabolism, suggesting an increase in the BCAA metabolic machinery.	Isoleucine	129-139	AT rich interactive domain 4B (RBP1-like)	Mus musculus	27-31
30830240-13	2019	Our results show that the capacity for cerebral BCAA metabolism, predominantly of isoleucine, is amplified in the R6/2 brain and indicates that perturbations in cerebral BCAA homeostasis could have functional consequences for HD pathology.	Isoleucine	82-92	AT rich interactive domain 4B (RBP1-like)	Mus musculus	48-52
30448992-5	2019	RESULTS: Circulating SELENOP levels were associated with 24 out of 572 metabolites after accounting for the number of independent dimensions in the metabolomics data, including inverse associations with alanine, glutamate, leucine, isoleucine and valine, an unknown compound X-12063, urate and the peptides gamma-glutamyl-leucine, and N-acetylcarnosine.	Isoleucine	232-242	selenoprotein P	Homo sapiens	21-28
31098606-7	2019	l-Leucine-, l-isoleucine- or BCAAs mix-induced CCK secretion was significantly decreased after tissues were pretreated with lactisole, a T1R1/T1R3 inhibitor (P &lt; 0.05).	Isoleucine	12-24	taste 1 receptor member 1	Homo sapiens	137-146
31098606-9	2019	l-Leucine, l-isoleucine and BCAAs mix appeared to induce the gut satiety hormone CCK secretion through jejunal T1R1/T1R3.	Isoleucine	11-23	cholecystokinin	Homo sapiens	81-84
31098606-9	2019	l-Leucine, l-isoleucine and BCAAs mix appeared to induce the gut satiety hormone CCK secretion through jejunal T1R1/T1R3.	Isoleucine	11-23	taste 1 receptor member 1	Homo sapiens	111-120
30945499-11	2019	In comparison with the model group, PC6-EA preconditioning induced significant changes, including an increase of glucose, and a decrease of leucine,isoleucine, valine,3-hydroxybutyric acid,lactate,acetate,acetone,acetoacetate acid,pyruvic acid,glutamine,creatine and glycerol.	Isoleucine	148-158	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	36-39
30819806-7	2019	Glutamate substitution of the A55 residue Ile-48, adjacent to the canonical phiX(D/E) Cul3-binding motif, reduced affinity of A55BB for Cul3-NTD by at least 2 orders of magnitude.	Isoleucine	42-45	cullin 3	Homo sapiens	86-90
30819806-7	2019	Glutamate substitution of the A55 residue Ile-48, adjacent to the canonical phiX(D/E) Cul3-binding motif, reduced affinity of A55BB for Cul3-NTD by at least 2 orders of magnitude.	Isoleucine	42-45	cullin 3	Homo sapiens	136-140
30819806-7	2019	Glutamate substitution of the A55 residue Ile-48, adjacent to the canonical phiX(D/E) Cul3-binding motif, reduced affinity of A55BB for Cul3-NTD by at least 2 orders of magnitude.	Isoleucine	42-45	fuzzy planar cell polarity protein	Homo sapiens	141-144
30655288-6	2019	Unlike the canonical PIP box of p68, the PIP box of p12 lacks the conserved glutamine; binds through a 2-fork plug made of an isoleucine and a tyrosine residue at +3 and +8 positions, respectively; and is stabilized by an aspartate at +6 position, which creates a network of intramolecular hydrogen bonds.	Isoleucine	126-136	DNA polymerase delta 4, accessory subunit	Homo sapiens	52-55
30909606-4	2019	Through molecular docking analysis, we found that 18b could fit into the middle of the TNF-a dimer and form hydrophobic interactions with Leu55, Leu57 chain A and B, Tyr59, Val123 chain B and D, Ile 155.	Isoleucine	195-198	tumor necrosis factor	Mus musculus	87-92
30598510-4	2019	The BGZP-C-binding site on InhA previously was reported to be located on the outside of the extended finger region, yet at the same time to include Ser-112 and Lys-119, homologous to TGF-beta2 Ile-92 and Lys-97, on the inside of the fingers.	Isoleucine	193-196	inhibin subunit alpha	Homo sapiens	27-31
30598510-4	2019	The BGZP-C-binding site on InhA previously was reported to be located on the outside of the extended finger region, yet at the same time to include Ser-112 and Lys-119, homologous to TGF-beta2 Ile-92 and Lys-97, on the inside of the fingers.	Isoleucine	193-196	transforming growth factor beta 2	Homo sapiens	183-192
30598510-2	2019	Included in this binding site are Ile-92, Lys-97, and Glu-99, which are entirely or mostly specific to the TGF-beta isoforms and the InhA alpha-subunit, but they are unconserved in other TGF-beta family growth factors (GFs).	Isoleucine	34-37	transforming growth factor beta 1	Homo sapiens	107-115
30598510-2	2019	Included in this binding site are Ile-92, Lys-97, and Glu-99, which are entirely or mostly specific to the TGF-beta isoforms and the InhA alpha-subunit, but they are unconserved in other TGF-beta family growth factors (GFs).	Isoleucine	34-37	inhibin subunit alpha	Homo sapiens	133-137
30641046-9	2019	Therefore, isoleucine residues 351 and 461, and leucine residue 355 are important for the cytochrome P450scc functioning towards sterols both with unbranched (cholesterol) and branched (sitosterol) side chains.	Isoleucine	11-21	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	90-108
30598510-2	2019	Included in this binding site are Ile-92, Lys-97, and Glu-99, which are entirely or mostly specific to the TGF-beta isoforms and the InhA alpha-subunit, but they are unconserved in other TGF-beta family growth factors (GFs).	Isoleucine	34-37	transforming growth factor beta 1	Homo sapiens	187-195
30823619-7	2019	As indicated by relevance networking, isoleucine, lysine, valine, histidine, and ornithine were the most discriminant for high RFI, whereas 3 biogenic amines (carnosine, putrescine, and spermidine) and 3 diacyl-glycerophospholipids (38:4, 38:5, and 40:5) positively correlated with feed intake and body weight gain, respectively.	Isoleucine	38-48	RFI	Gallus gallus	127-130
30295033-0	2018	Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2.	Isoleucine	34-37	angiotensin I converting enzyme 2	Rattus norvegicus	66-97
30617052-8	2019	For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA =0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA =0.010).	Isoleucine	35-38	glutathione S-transferase pi 1	Homo sapiens	29-34
30379325-7	2019	Uniporter LAT4 selectively transports the branched chain amino acids leucine, isoleucine and valine, and additionally methionine and phenylalanine.	Isoleucine	78-88	solute carrier family 43, member 2	Mus musculus	10-14
29185836-8	2019	One of the ANKRD26 SNVs - rs191015656, encoding a threonine to isoleucine substitution predicted to alter protein structure/function, was replicated in Europeans.	Isoleucine	63-73	ankyrin repeat domain containing 26	Homo sapiens	11-18
30598820-7	2018	Conclusions: Surplus dietary Ile intake could increase IMF accumulation and MUFA synthesis in skeletal muscle through depressing the phosphorylation of AMPKalpha-ACC and stimulating the expression and activity of SCD, and increasing the capability of lipogenesis in skeletal muscle.	Isoleucine	29-32	Monounsaturated fatty acid percentage	Sus scrofa	76-80
30352217-5	2018	We observed that cdk8 and cycC mutants are sensitive to the levels of dietary proteins and seven amino acids (arginine, glutamine, isoleucine, leucine, methionine, threonine, and valine).	Isoleucine	131-141	Cyclin-dependent kinase 8	Drosophila melanogaster	17-21
30352217-5	2018	We observed that cdk8 and cycC mutants are sensitive to the levels of dietary proteins and seven amino acids (arginine, glutamine, isoleucine, leucine, methionine, threonine, and valine).	Isoleucine	131-141	Cyclin C	Drosophila melanogaster	26-30
30541556-18	2018	ECHS1 is involved in valine (-log (p = 3.39E00)), isoleucine degradation (p = 0.00457), fatty acid beta-oxidation (-log(p) = 2.83E00), and drug metabolism:cytochrome P450 (z-score = 2.07985196) pathways.	Isoleucine	50-60	enoyl-CoA hydratase, short chain 1	Homo sapiens	0-5
30563270-10	2018	Nevertheless, our data suggest that only an increase in total BCAA, also richer in single AA leucine, isoleucine, and methionine, is associated with the maintenance and/or increase of SMM.	Isoleucine	102-112	AT-rich interaction domain 4B	Homo sapiens	62-66
30077773-4	2018	METHODS: Using site-directed mutagenesis, the human GAPDH clone was mutated at one of the NAD+-binding sites, (i.e.) arginine (R13) and isoleucine (I14) to glutamine (Q13) and phenylalanine (F14), respectively.	Isoleucine	136-146	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-57
30268610-9	2018	Supplementation of a complete mixture of essential AA or Arg, Val, Leu, His, Phe, Met, and Ile individually led to greater mTOR phosphorylation.	Isoleucine	91-94	mechanistic target of rapamycin kinase	Bos taurus	123-127
30268610-10	2018	Phosphorylation of ribosomal protein S6 kinase beta-1 was greater in the presence of Val, Leu, Trp, Met, and Ile.	Isoleucine	109-112	ribosomal protein S6 kinase B1	Bos taurus	19-53
30268610-11	2018	Valine, Leu, Met, and Ile led to greater eIF4E-binding protein 1 phosphorylation.	Isoleucine	22-25	eukaryotic translation initiation factor 4E binding protein 1	Bos taurus	41-64
30288935-4	2018	The TRNOE crosspeaks in the ternary complex were assigned to the specific Tyr protons in the CCR5 peptide and to methyl protons of isoleucine, leucine and/or valine residues of gp120.	Isoleucine	131-141	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	177-182
29125030-5	2018	Moreover, the residue interaction networks analysis, the hydrogen bond occupancy analysis and the binding free energies were calculated to gain detailed insight into the influence of the mutant D61G on the two regions, revealing that the major differences between SHP2-WT and SHP2-D61G were the different interactions between Gly 61 and Gly 462, Gly 61 and Ala 461, Gln 506 and Ile 463, Gly 61 and Asn 58, Ile 463 and Thr 466, Gly 462 and Cys 459.	Isoleucine	378-381	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	276-280
29125030-5	2018	Moreover, the residue interaction networks analysis, the hydrogen bond occupancy analysis and the binding free energies were calculated to gain detailed insight into the influence of the mutant D61G on the two regions, revealing that the major differences between SHP2-WT and SHP2-D61G were the different interactions between Gly 61 and Gly 462, Gly 61 and Ala 461, Gln 506 and Ile 463, Gly 61 and Asn 58, Ile 463 and Thr 466, Gly 462 and Cys 459.	Isoleucine	406-409	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	276-280
30449824-1	2018	L-type amino acid transporter 1 (LAT1) functions to transport large neutral amino acids, such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Isoleucine	106-116	solute carrier family 7 member 5	Homo sapiens	0-31
30449824-1	2018	L-type amino acid transporter 1 (LAT1) functions to transport large neutral amino acids, such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Isoleucine	106-116	solute carrier family 7 member 5	Homo sapiens	33-37
30295033-2	2018	Our previous studies indicated that egg white-derived antihypertensive peptide IRW (Ile-Arg-Trp) could upregulate ACE2 mRNA level in mesenteric artery of spontaneously hypertensive rats (SHRs), suggesting the potential of IRW as an in vivo ACE2 activator.	Isoleucine	84-87	angiotensin I converting enzyme 2	Rattus norvegicus	114-118
30295033-2	2018	Our previous studies indicated that egg white-derived antihypertensive peptide IRW (Ile-Arg-Trp) could upregulate ACE2 mRNA level in mesenteric artery of spontaneously hypertensive rats (SHRs), suggesting the potential of IRW as an in vivo ACE2 activator.	Isoleucine	84-87	angiotensin I converting enzyme 2	Rattus norvegicus	240-244
31020184-1	2018	Background: Approximately 4% of the African-American population possess a valine-to-isoleucine (V122I) substitution within the transthyretin protein that results in a tendency for a normally tetrameric protein to dissociate into misfolded, monomeric subunits.	Isoleucine	84-94	transthyretin	Homo sapiens	127-140
29570813-2	2018	Polymorphisms in TAS2R38 generate two common haplotypes: the nonfunctional AVI (Alanine, Valine, Isoleucine) and the functional PAV (Proline, Alanine, Valine) alleles, with the latter protecting against gram-negative sinonasal infections.	Isoleucine	97-107	taste 2 receptor member 38	Homo sapiens	17-24
30291234-3	2018	Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo(L-Trp-L-Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala).	Isoleucine	124-127	doublesex and mab-3 related transcription factor 1	Homo sapiens	47-51
30063118-1	2018	Branched-chain amino acids (BCAA: leucine, isoleucine and valine) are essential amino acids implicated in glucose metabolism and maintenance of correct brain function.	Isoleucine	43-53	AT-rich interaction domain 4B	Homo sapiens	28-32
30154163-3	2018	Here we report using the QTY code to systematically replace the hydrophobic amino acids leucine, valine, isoleucine, and phenylalanine in the seven transmembrane alpha-helices of CCR5, CXCR4, CCR10, and CXCR7.	Isoleucine	105-115	C-C motif chemokine receptor 5	Homo sapiens	179-183
30021898-3	2018	Changes in "restraining" amino acid residues, such as leucine 193 and isoleucine 423, destabilize State 1 Env, which then assumes entry-competent, downstream conformations.	Isoleucine	70-80	endogenous retrovirus group K member 20	Homo sapiens	106-109
30154163-3	2018	Here we report using the QTY code to systematically replace the hydrophobic amino acids leucine, valine, isoleucine, and phenylalanine in the seven transmembrane alpha-helices of CCR5, CXCR4, CCR10, and CXCR7.	Isoleucine	105-115	C-X-C motif chemokine receptor 4	Homo sapiens	185-190
30154163-3	2018	Here we report using the QTY code to systematically replace the hydrophobic amino acids leucine, valine, isoleucine, and phenylalanine in the seven transmembrane alpha-helices of CCR5, CXCR4, CCR10, and CXCR7.	Isoleucine	105-115	C-C motif chemokine receptor 10	Homo sapiens	192-197
30154163-3	2018	Here we report using the QTY code to systematically replace the hydrophobic amino acids leucine, valine, isoleucine, and phenylalanine in the seven transmembrane alpha-helices of CCR5, CXCR4, CCR10, and CXCR7.	Isoleucine	105-115	atypical chemokine receptor 3	Homo sapiens	203-208
30142967-3	2018	However, the way in which Ca2+/CaM/CaMKII cascade modulates NaV1.1 IQ (isoleucine and glutamine) domain of VGSCs remains obscure.	Isoleucine	71-81	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	35-41
30031876-4	2018	Recent studies also reported a substitution at position Met141 on the yeast ISCU orthologue Isu, to Ile, Leu, Val, or Cys, could bypass the requirement of FXN for Fe-S cluster biosynthesis and cell viability.	Isoleucine	100-103	iron-sulfur cluster assembly enzyme	Homo sapiens	76-80
30031876-4	2018	Recent studies also reported a substitution at position Met141 on the yeast ISCU orthologue Isu, to Ile, Leu, Val, or Cys, could bypass the requirement of FXN for Fe-S cluster biosynthesis and cell viability.	Isoleucine	100-103	frataxin	Homo sapiens	155-158
29997204-5	2018	Our data demonstrated that replacing isoleucine 146 in H-linker (H-I146) with any charged amino acids prevented virus-mediated membrane fusion activity, despite proper trafficking of the mutants to the cell surface and preserved binding efficiency to the SLAM/CD150 receptor.	Isoleucine	37-47	signaling lymphocytic activation molecule family member 1	Homo sapiens	255-274
29994805-4	2018	BCAAs - the essential amino acids leucine, isoleucine and valine - likely promote insulin resistance through activation of mammalian target of rapamycin complex 1.	Isoleucine	43-53	insulin	Homo sapiens	82-89
30142967-3	2018	However, the way in which Ca2+/CaM/CaMKII cascade modulates NaV1.1 IQ (isoleucine and glutamine) domain of VGSCs remains obscure.	Isoleucine	71-81	sodium voltage-gated channel alpha subunit 1	Homo sapiens	60-66
30072900-7	2018	They also potently inhibited isoleucine uptake via LAT1 (SLC7A5), a transporter that is upregulated in cancer cells together with ASCT2.	Isoleucine	29-39	solute carrier family 7 member 5	Homo sapiens	51-55
29752946-9	2018	There was a significant positive correlation between serine (p &lt; 0.021), alanine (p &lt; 0.00016), phenylalanine (p &lt; 0.04), isoleucine (p &lt; 0.023), leucine (p &lt; 0.043), and lysine (p &lt; 0.026) with adiponectin level in the vitreous.	Isoleucine	131-141	adiponectin, C1Q and collagen domain containing	Homo sapiens	213-224
29752946-12	2018	TGFbeta mRNA expression showed a significant decrease with proline, alanine, glycine, lysine and isoleucine.	Isoleucine	97-107	transforming growth factor beta 1	Homo sapiens	0-7
30064355-8	2018	Each of the two SNPs identified in Hfr-1 and Hfr-2 is "G/A" and resulted in an amino acid change from isoleucine to valine in the lectin domain of the proteins of the alleles in the R cultivars.	Isoleucine	102-112	uncharacterized protein LOC542941	Triticum aestivum	35-50
30072900-7	2018	They also potently inhibited isoleucine uptake via LAT1 (SLC7A5), a transporter that is upregulated in cancer cells together with ASCT2.	Isoleucine	29-39	solute carrier family 7 member 5	Homo sapiens	57-63
30072900-7	2018	They also potently inhibited isoleucine uptake via LAT1 (SLC7A5), a transporter that is upregulated in cancer cells together with ASCT2.	Isoleucine	29-39	solute carrier family 1 member 5	Homo sapiens	130-135
29950729-6	2018	The in trans mutations occurred at glutamine 316 (Q316E) and isoleucine 319 (I319M), which are at the interface where enasidenib binds to the IDH2 dimer.	Isoleucine	61-71	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	142-146
29936356-7	2018	Using an inhibitor library based on SFTI-1, we show that the inhibitor"s P2" residue (Ile) is a key contributor to SFTI-1"s limited activity against mesotrypsin.	Isoleucine	86-89	serine protease 3	Homo sapiens	149-160
29915081-6	2018	Unlike accurate LeuRS synthetases from other eukaryotic species, microsporidian LeuRS is error-prone: apart from leucine, it occasionally uses its near-cognate substrates, such as norvaline, isoleucine, valine, and methionine.	Isoleucine	191-201	leucyl-tRNA synthetase 2, mitochondrial	Homo sapiens	80-85
29543898-10	2018	Bioinformatics analysis of PPARalpha showed that SNP2 leads to an amino acid substitution of Ile for Met, which results in the protein being more likely to be hydrolyzed.	Isoleucine	93-96	peroxisome proliferator activated receptor alpha	Gallus gallus	27-36
29742810-7	2018	When at4g16800 knockout plants were subjected to dark-induced carbon starvation, their rosette leaves displayed accelerated senescence as compared with control plants, and this phenotype was paralleled by a marked increase in the accumulation of free and total leucine, isoleucine and valine.	Isoleucine	270-280	ATP-dependent caseinolytic (Clp) protease/crotonase family protein	Arabidopsis thaliana	5-14
29963014-6	2018	The DPP-IV half maximal inhibitory concentration (IC50) values of the 25 peptides evaluated ranged from 3.9 +- 1.0 microM (Ile-Pro-Ile) to 247.0 +- 32.7 microM (Phe-Pro-Phe).	Isoleucine	123-126	dipeptidyl peptidase 4	Homo sapiens	4-10
29963014-6	2018	The DPP-IV half maximal inhibitory concentration (IC50) values of the 25 peptides evaluated ranged from 3.9 +- 1.0 microM (Ile-Pro-Ile) to 247.0 +- 32.7 microM (Phe-Pro-Phe).	Isoleucine	131-134	dipeptidyl peptidase 4	Homo sapiens	4-10
29989088-8	2018	We herein report 4 novel inhibitor candidates of Asp-Ile-Phe, Asp-Ile-Tyr, Asp-Ile-Lys and Hser-Gly-Phe with high potency and selectivity binding to MMP-2, as well as 6 novel inhibitor candidates of Chg-Ile-Ile, Chg-Ile-Leu, Chg-Ile-Glu, Chg-Ile-Met, Chg-Val-Ile and Chg-Val-Leu selectively binding to MMP-7.	Isoleucine	53-56	matrix metallopeptidase 2	Homo sapiens	149-154
29989088-8	2018	We herein report 4 novel inhibitor candidates of Asp-Ile-Phe, Asp-Ile-Tyr, Asp-Ile-Lys and Hser-Gly-Phe with high potency and selectivity binding to MMP-2, as well as 6 novel inhibitor candidates of Chg-Ile-Ile, Chg-Ile-Leu, Chg-Ile-Glu, Chg-Ile-Met, Chg-Val-Ile and Chg-Val-Leu selectively binding to MMP-7.	Isoleucine	53-56	matrix metallopeptidase 7	Homo sapiens	302-307
29496997-6	2018	Moreover, substitutions of key residues, specifically Ile-915 and Asn-916, converted SDG8-CW binding preference from H3K4me1 to H3K4me3.	Isoleucine	54-57	histone-lysine N-methyltransferase	Arabidopsis thaliana	85-89
29636417-4	2018	This residue, located at "canonical" position 255, where it is Ile in human pancreatic carboxypeptidases A1 (hCPA1) and A2 (hCPA2) and Asp in B (hCPB), plays a dominant role in determining the preference of hCPO for acidic C-t residues.	Isoleucine	63-66	carboxypeptidase A1	Homo sapiens	109-114
29636417-4	2018	This residue, located at "canonical" position 255, where it is Ile in human pancreatic carboxypeptidases A1 (hCPA1) and A2 (hCPA2) and Asp in B (hCPB), plays a dominant role in determining the preference of hCPO for acidic C-t residues.	Isoleucine	63-66	carboxypeptidase A2	Homo sapiens	124-129
29636417-4	2018	This residue, located at "canonical" position 255, where it is Ile in human pancreatic carboxypeptidases A1 (hCPA1) and A2 (hCPA2) and Asp in B (hCPB), plays a dominant role in determining the preference of hCPO for acidic C-t residues.	Isoleucine	63-66	carboxypeptidase O	Homo sapiens	207-211
29191093-4	2018	Leucine and isoleucine levels were significantly lower in the skin of BDK-KO mice compared with wild-type mice.	Isoleucine	12-22	branched chain keto acid dehydrogenase kinase	Homo sapiens	70-73
29191093-8	2018	These findings suggest that deficiencies of leucine and isoleucine reduce type I and III tropocollagen syntheses in skin by suppressing the action of mTOR.	Isoleucine	56-66	mechanistic target of rapamycin kinase	Mus musculus	150-154
29486965-3	2018	This study reports an in vitro enzymatic method for synthesizing OPDA-Ile, which is catalyzed by reactions of lipoxygenase (LOX), allene oxide synthase (AOS), and allene oxide cyclase (AOC) using isoleucine conjugates of alpha -linolenic acid (LA-Ile) as the substrate.	Isoleucine	196-206	lipoxygenase 1	Arabidopsis thaliana	110-122
29486965-3	2018	This study reports an in vitro enzymatic method for synthesizing OPDA-Ile, which is catalyzed by reactions of lipoxygenase (LOX), allene oxide synthase (AOS), and allene oxide cyclase (AOC) using isoleucine conjugates of alpha -linolenic acid (LA-Ile) as the substrate.	Isoleucine	196-206	lipoxygenase 1	Arabidopsis thaliana	124-127
29850466-1	2018	In the yeast Saccharomyces cerevisiae, the branched-chain amino acid aminotransferases (BCATs) Bat1 and Bat2 catalyze the conversion of alpha-ketoisovalerate, alpha-keto-beta-methylvalerate, and alpha-ketoisokaproate and into valine, isoleucine, and leucine, respectively, as the final step of branched-chain amino acid biosynthesis.	Isoleucine	234-244	branched-chain-amino-acid transaminase BAT1	Saccharomyces cerevisiae S288C	95-99
29850466-1	2018	In the yeast Saccharomyces cerevisiae, the branched-chain amino acid aminotransferases (BCATs) Bat1 and Bat2 catalyze the conversion of alpha-ketoisovalerate, alpha-keto-beta-methylvalerate, and alpha-ketoisokaproate and into valine, isoleucine, and leucine, respectively, as the final step of branched-chain amino acid biosynthesis.	Isoleucine	234-244	branched-chain-amino-acid transaminase BAT2	Saccharomyces cerevisiae S288C	104-108
29936232-2	2018	From patients with frontotemporal lobar degeneration with distinct atypical clinical phenotypes, we recently identified two new mutations on the same codon, in position 363 of the MAPT gene, which resulted in the production of Val-to-Ala (tauV363A) or Val-to-Ile (tauV363I) mutated tau.	Isoleucine	259-262	microtubule associated protein tau	Homo sapiens	180-184
29936232-2	2018	From patients with frontotemporal lobar degeneration with distinct atypical clinical phenotypes, we recently identified two new mutations on the same codon, in position 363 of the MAPT gene, which resulted in the production of Val-to-Ala (tauV363A) or Val-to-Ile (tauV363I) mutated tau.	Isoleucine	259-262	microtubule associated protein tau	Homo sapiens	239-242
29530594-11	2018	Ala81 and Gly83 evolve to Ile and Val, respectively, in human cytochrome c and peroxidase activity decreases 25-fold relative to the yeast protein at pH 7.	Isoleucine	26-29	cytochrome c, somatic	Homo sapiens	62-74
29714061-0	2018	Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Inhibits Angiotensin II-Stimulated Migration of Vascular Smooth Muscle Cells via Angiotensin Type I Receptor.	Isoleucine	48-51	angiotensinogen	Rattus norvegicus	70-84
29714061-3	2018	In addition to reducing high blood pressure in spontaneously hypertensive rats, egg white ovotransferrin-derived antihypertensive IRW (Ile-Arg-Trp) was shown to exert antiproliferative, antioxidant, and anti-inflammatory effects in A7r5 cells (a vascular smooth muscle cell line) against Ang II stimulation, further indicating its potential in retarding vascular remodelling.	Isoleucine	135-138	angiotensinogen	Rattus norvegicus	288-294
29539269-2	2018	The core jasmonate signaling pathway comprises several functional modules, including a repertoire of COI1-JAZ (CORONATINE INSENSITIVE1-JASMONATE-ZIM DOMAIN) coreceptors that couple jasmonoyl-l-isoleucine perception to the degradation of JAZ repressors, JAZ-interacting transcription factors that execute physiological responses, and multiple negative feedback loops to ensure timely termination of these responses.	Isoleucine	191-203	zinc finger protein 346	Homo sapiens	106-109
29539269-2	2018	The core jasmonate signaling pathway comprises several functional modules, including a repertoire of COI1-JAZ (CORONATINE INSENSITIVE1-JASMONATE-ZIM DOMAIN) coreceptors that couple jasmonoyl-l-isoleucine perception to the degradation of JAZ repressors, JAZ-interacting transcription factors that execute physiological responses, and multiple negative feedback loops to ensure timely termination of these responses.	Isoleucine	191-203	zinc finger protein 346	Homo sapiens	237-240
29539269-2	2018	The core jasmonate signaling pathway comprises several functional modules, including a repertoire of COI1-JAZ (CORONATINE INSENSITIVE1-JASMONATE-ZIM DOMAIN) coreceptors that couple jasmonoyl-l-isoleucine perception to the degradation of JAZ repressors, JAZ-interacting transcription factors that execute physiological responses, and multiple negative feedback loops to ensure timely termination of these responses.	Isoleucine	191-203	zinc finger protein 346	Homo sapiens	237-240
29424242-5	2018	Studies using in vivo and in vitro reporters of Rce1 activity have revealed that the enzyme cleaves only prenylated substrates and the identity of the a2 amino residue in the Ca1a2X sequence is most critical for recognition, preferring Ile, Leu, or Val.	Isoleucine	236-239	Ras converting CAAX endopeptidase 1	Homo sapiens	48-52
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Isoleucine	69-72	xanthine phosphoribosyltransferase	Leishmania donovani	40-44
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Isoleucine	69-72	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Isoleucine	69-72	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29035969-1	2018	PURPOSE OF REVIEW: The current review highlights the varied effects of medical foods high in leucine (Leu) and devoid of valine (Val) and isoleucine (Ile) in the management of methylmalonic acidemia (MMA) and propionic acidemia and cobalamin C (cblC) deficiency, aiming to advance dietary practices.	Isoleucine	150-153	Cbl proto-oncogene C	Homo sapiens	232-243
29320694-6	2018	An initial set of simulations was performed to investigate a single lid region mutation G230I in hSTING (corresponding residue in mSTING is an Ile), which rendered the protein sensitive to DMXAA.	Isoleucine	143-146	stimulator of interferon response cGAMP interactor 1	Homo sapiens	97-103
30032685-4	2018	She was found to be carrier of a novel unstable Hb variant, Hb Oslo [beta42(CD1)Phe Ile (TTT&gt;ATT), HBB: c.127T&gt;A] located in the heme pocket of the beta-globin chain.	Isoleucine	84-87	CD1c molecule	Homo sapiens	76-79
29352967-3	2018	9S-DOX-allene oxide synthase (AOS) oxidized the Gly, Ile, and Trp derivatives at C-9, which suggests that these conjugates enter the substrate recognition site with the omega end in analogy with fatty acids bound to cyclooxygenases and coral 8R-lipoxygenase (8R-LOX).	Isoleucine	53-56	complement C9	Homo sapiens	81-84
29266268-7	2018	Branched-chain amino acids (BCAAs; leucine, isoleucine and valine) are elevated in the blood of obese, insulin-resistant humans and rodents.	Isoleucine	44-54	insulin	Homo sapiens	103-110
29339254-9	2018	For the future optimization of the generated inhibitors, (i) antioxidant activity against SOD, (ii) the inhibitor stabilization by pi-cation interaction with the catalytic Fe+3 and (iii) formation of hydrogen bond with Ile 676 should be regarded.	Isoleucine	219-222	superoxide dismutase 1	Homo sapiens	90-93
29156952-7	2018	Isoleucine linearly increased plasma insulin in Exp 1, but not in Exp 2.	Isoleucine	0-10	insulin	Homo sapiens	37-44
29156952-7	2018	Isoleucine linearly increased plasma insulin in Exp 1, but not in Exp 2.	Isoleucine	0-10	exportin 1	Homo sapiens	48-53
29127264-6	2018	Such noncatalytic phenotypes were frequent in the Alt1 and Bat2 transaminases and in the isoleucine/valine biosynthetic enzymes Ilv1 and Ilv2, suggesting novel "moonlighting" activities in these proteins.	Isoleucine	89-99	alanine transaminase ALT1	Saccharomyces cerevisiae S288C	50-54
29127264-6	2018	Such noncatalytic phenotypes were frequent in the Alt1 and Bat2 transaminases and in the isoleucine/valine biosynthetic enzymes Ilv1 and Ilv2, suggesting novel "moonlighting" activities in these proteins.	Isoleucine	89-99	branched-chain-amino-acid transaminase BAT2	Saccharomyces cerevisiae S288C	59-63
29127264-6	2018	Such noncatalytic phenotypes were frequent in the Alt1 and Bat2 transaminases and in the isoleucine/valine biosynthetic enzymes Ilv1 and Ilv2, suggesting novel "moonlighting" activities in these proteins.	Isoleucine	89-99	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	128-132
29127264-6	2018	Such noncatalytic phenotypes were frequent in the Alt1 and Bat2 transaminases and in the isoleucine/valine biosynthetic enzymes Ilv1 and Ilv2, suggesting novel "moonlighting" activities in these proteins.	Isoleucine	89-99	acetolactate synthase catalytic subunit	Saccharomyces cerevisiae S288C	137-141
29356095-10	2018	DNA sequencing indicated that this Pomeranian family carried a CYB5R3 gene missense variant (ATC CTC at codon 194) that resulted in the replacement of isoleucine (Ile) by leucine (Leu).	Isoleucine	151-161	cytochrome b5 reductase 3	Canis lupus familiaris	63-69
30612495-4	2018	Sanger sequencing revealed a novel mutation [alpha67(E16)Thr Ile, HBA2: c.203C&gt;T].	Isoleucine	61-64	hemoglobin subunit alpha 2	Homo sapiens	66-70
30099452-7	2018	The docking results revealed that compound 8 forms 2 hydrogen bonds with the residues of Gly-216 and Ile-218 in 11beta-HSD1, that is to say compound 8 maybe a good 11beta-HSD1 inhibitor.	Isoleucine	101-104	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	112-123
30099452-7	2018	The docking results revealed that compound 8 forms 2 hydrogen bonds with the residues of Gly-216 and Ile-218 in 11beta-HSD1, that is to say compound 8 maybe a good 11beta-HSD1 inhibitor.	Isoleucine	101-104	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	164-175
29210629-16	2018	BP-14 peptide contained Ser- Thr-Tyr and Pro-Phe-Glu sequences, which are similar to the Ser-Thr-Trp and Ile-Phe-Glu sequences found in M12-6a, suggesting that one or both of these tripeptides may be the binding motif(s) recognized by Scp1.	Isoleucine	105-108	BP14	Homo sapiens	0-5
29141216-3	2017	Here, we show that branched-chain amino acids (BCAAs), including isoleucine, are required for maintenance of the proliferative state of Treg cells via the amino acid transporter Slc3a2-dependent metabolic reprogramming.	Isoleucine	65-75	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	178-184
28118528-8	2017	BLyS levels were intermediate in ILE patients (controls &lt; ILE; P = 0.016; ILE &lt; SLE; P = 0.008).	Isoleucine	33-36	TNF superfamily member 13b	Homo sapiens	0-4
28513068-2	2017	The objective of this study was to evaluate whether serum concentrations of BCAAs (leucine, isoleucine, valine) could mediate in insulin sensitivity and glucose tolerance after continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA).	Isoleucine	92-102	insulin	Homo sapiens	129-136
28875337-0	2017	Clinical and molecular analysis of 6 Chinese patients with isoleucine metabolism defects: identification of 3 novel mutations in the HSD17B10 and ACAT1 gene.	Isoleucine	59-69	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	133-141
28875337-0	2017	Clinical and molecular analysis of 6 Chinese patients with isoleucine metabolism defects: identification of 3 novel mutations in the HSD17B10 and ACAT1 gene.	Isoleucine	59-69	acetyl-CoA acetyltransferase 1	Homo sapiens	146-151
28875337-1	2017	Hydroxysteroid (17beta) dehydrogenase 10 (HSD10) and mitochondrial acetoacetyl-CoA thiolase (beta-KT) are two adjacent enzymes for the degradation of isoleucine, thus HSD10 and beta-KT deficiencies are confusing at an early stage because of nearly the same elevation of typical metabolites in urine, such as 2-methyl-3-hydroxybutyric acid (2M3HBA) and tiglylglycine (TG).	Isoleucine	150-160	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	0-40
28875337-1	2017	Hydroxysteroid (17beta) dehydrogenase 10 (HSD10) and mitochondrial acetoacetyl-CoA thiolase (beta-KT) are two adjacent enzymes for the degradation of isoleucine, thus HSD10 and beta-KT deficiencies are confusing at an early stage because of nearly the same elevation of typical metabolites in urine, such as 2-methyl-3-hydroxybutyric acid (2M3HBA) and tiglylglycine (TG).	Isoleucine	150-160	fibrous sheath interacting protein 1	Homo sapiens	42-47
28875337-1	2017	Hydroxysteroid (17beta) dehydrogenase 10 (HSD10) and mitochondrial acetoacetyl-CoA thiolase (beta-KT) are two adjacent enzymes for the degradation of isoleucine, thus HSD10 and beta-KT deficiencies are confusing at an early stage because of nearly the same elevation of typical metabolites in urine, such as 2-methyl-3-hydroxybutyric acid (2M3HBA) and tiglylglycine (TG).	Isoleucine	150-160	acetyl-CoA acetyltransferase 1	Homo sapiens	53-91
28875337-1	2017	Hydroxysteroid (17beta) dehydrogenase 10 (HSD10) and mitochondrial acetoacetyl-CoA thiolase (beta-KT) are two adjacent enzymes for the degradation of isoleucine, thus HSD10 and beta-KT deficiencies are confusing at an early stage because of nearly the same elevation of typical metabolites in urine, such as 2-methyl-3-hydroxybutyric acid (2M3HBA) and tiglylglycine (TG).	Isoleucine	150-160	fibrous sheath interacting protein 1	Homo sapiens	167-172
29141216-6	2017	Slc3a2-deficient Treg cells showed impaired isoleucine-induced activation of the mTORC1 pathway and an altered metabolic state.	Isoleucine	44-54	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	0-6
29141216-6	2017	Slc3a2-deficient Treg cells showed impaired isoleucine-induced activation of the mTORC1 pathway and an altered metabolic state.	Isoleucine	44-54	CREB regulated transcription coactivator 1	Mus musculus	81-87
29053759-1	2017	The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine at 164th position in beta2AR and results in receptor sequestration and altered binding of agonists.	Isoleucine	77-87	adrenoceptor beta 2	Homo sapiens	41-46
28851624-3	2017	The important question here is as to what will happen in terms of folding and stability if Leu94 of the mammalian cyt c is substituted by Val or Ile.	Isoleucine	145-148	cytochrome c, somatic	Equus caballus	114-119
28728917-5	2017	By employing computational analysis, 15 conserved residues in the drug-binding pocket of human P-gp that interact with substrates were identified and then substituted with tyrosine, including 11 phenylalanine (F72, F303, F314, F336, F732, F759, F770, F938, F942, F983, F994), two leucine (L339, L975), one isoleucine (I306), and one methionine (M949).	Isoleucine	306-316	ATP binding cassette subfamily B member 1	Homo sapiens	95-99
29053759-1	2017	The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine at 164th position in beta2AR and results in receptor sequestration and altered binding of agonists.	Isoleucine	77-87	adrenoceptor beta 2	Homo sapiens	109-116
28771902-5	2017	To that purpose, we designed pulse sequences for the measurement of cross-correlated relaxation between the backbone HN -N and side-chain Hbeta -Cbeta dipoles in Ile, Thr, and Val in the protein GB3.	Isoleucine	162-165	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	195-198
28876052-2	2017	A recently discovered antiparallel coiled-coil hexamer (ACC-Hex, peptide 1) exhibits a unique interaction in which Phe and Ile residues from adjacent alpha-helices interact to form a Phe-Ile zipper within the hydrophobic core.	Isoleucine	123-126	hematopoietically expressed homeobox	Homo sapiens	60-63
28876052-3	2017	Analysis of the X-ray crystallographic structure of ACC-Hex suggests that the stability of the six-helix bundle relies on specific interactions between the Phe and Ile residues.	Isoleucine	164-167	hematopoietically expressed homeobox	Homo sapiens	56-59
28876052-6	2017	Using size exclusion chromatography and small-angle X-ray scattering, we found that the proper assembly of ACC-Hex from monomers is sensitive to subtle changes in side chain steric bulk and hydrophobicity introduced by mutations at the Phe and Ile residue positions.	Isoleucine	244-247	hematopoietically expressed homeobox	Homo sapiens	111-114
28876052-9	2017	Finally, we expanded on the generality of the Phe-Ile zipper, creating a unique sequence that forms an antiparallel hexamer that is topologically similar to ACC-Hex but atomistically unique.	Isoleucine	50-53	hematopoietically expressed homeobox	Homo sapiens	161-164
27959497-1	2017	Previous studies of transgenic mice carrying a single isoleucine to methionine substitution (I172M) in the serotonin transporter (SERT) demonstrated a loss of sensitivity to multiple antidepressants (ADs) at SERT.	Isoleucine	54-64	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	107-128
28904371-3	2017	The clearest effects of insulin were to reduce plasma levels of the branched chain amino acids (BCAs) leucine/isoleucine and their deaminated metabolites, and lowered free fatty acids and acylcarnitines.	Isoleucine	110-120	insulin	Homo sapiens	24-31
28887476-6	2017	Moreover, characterization of phage Vp16 PDF underscores unexpected structural and molecular features with the C-terminal Isoleucine residue significantly contributing to deformylase activity both in vitro and in vivo.	Isoleucine	122-132	host cell factor C1	Homo sapiens	36-40
28887476-6	2017	Moreover, characterization of phage Vp16 PDF underscores unexpected structural and molecular features with the C-terminal Isoleucine residue significantly contributing to deformylase activity both in vitro and in vivo.	Isoleucine	122-132	peptide deformylase, mitochondrial	Homo sapiens	41-44
28672086-7	2017	A positive significant correlation was observed between insulin levels and both leucine and isoleucine (r = 0.232; P &lt; 0.05).	Isoleucine	92-102	insulin	Homo sapiens	56-63
28373278-11	2017	TAS2R38 polymorphisms encode functional (PAV: proline, alanine, and valine at positions 49, 262, and 296, respectively) or non-functional (AVI: alanine, valine, isoleucine at positions 49, 262, and 296, respectively) T2R38.	Isoleucine	161-171	taste 2 receptor member 38	Homo sapiens	0-7
27959497-1	2017	Previous studies of transgenic mice carrying a single isoleucine to methionine substitution (I172M) in the serotonin transporter (SERT) demonstrated a loss of sensitivity to multiple antidepressants (ADs) at SERT.	Isoleucine	54-64	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	130-134
27959497-1	2017	Previous studies of transgenic mice carrying a single isoleucine to methionine substitution (I172M) in the serotonin transporter (SERT) demonstrated a loss of sensitivity to multiple antidepressants (ADs) at SERT.	Isoleucine	54-64	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	208-212
28194737-10	2017	The deuterium on Tyr amide of neurotensin (9-13), Arg-Pro-Tyr-Ile-Leu, migrated significantly faster than that on Ile or Leu amides, indicating the loss of deuterium from the original sites is not mere randomization of hydrogen and deuterium but more site-specific phenomena.	Isoleucine	62-65	neurotensin	Homo sapiens	30-41
28237591-7	2017	Supplementation of Ile, Leu, and Met increased phosphorylation of mTOR by 55, 34, and 47%, respectively, as compared with the protein-deficient diet.	Isoleucine	19-22	mechanistic target of rapamycin kinase	Mus musculus	66-70
28237591-8	2017	Phosphorylation of 4eBP1 increased in response to Ile and Met supplementation by 60 and 40%, respectively.	Isoleucine	50-53	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	19-24
28237591-9	2017	Supplementation of Ile and Met increased phosphorylation of Akt/protein kinase B (Akt) by 41 and 59%, respectively.	Isoleucine	19-22	thymoma viral proto-oncogene 1	Mus musculus	60-63
28237591-9	2017	Supplementation of Ile and Met increased phosphorylation of Akt/protein kinase B (Akt) by 41 and 59%, respectively.	Isoleucine	19-22	thymoma viral proto-oncogene 1	Mus musculus	82-85
27159682-6	2017	Except the known m.11778G > A mutation, the m.11696G > A(MT-ND4) mutation caused the substitution of an isoleucine for valineat amino acid position 313, located in a predicted transmembrane region of ND4.	Isoleucine	104-114	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	57-63
27159682-6	2017	Except the known m.11778G > A mutation, the m.11696G > A(MT-ND4) mutation caused the substitution of an isoleucine for valineat amino acid position 313, located in a predicted transmembrane region of ND4.	Isoleucine	104-114	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	60-63
28246168-8	2017	Chemical footprinting revealed that Ile-16 is significantly less protected from chemical modification in G221E than in wild-type HABP2, suggesting impaired insertion of the N terminus into the G221E protease domain, with a concomitant impact on catalytic activity.	Isoleucine	36-39	hyaluronan binding protein 2	Homo sapiens	129-134
28287731-7	2017	The best analogues were obtained by the incorporation of the Ile residue at the P5 and P6 positions.	Isoleucine	61-64	solute carrier family 10 member 5	Homo sapiens	80-89
28551094-4	2017	METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr705, and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin.	Isoleucine	139-142	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
28551094-4	2017	METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr705, and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin.	Isoleucine	139-142	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
28885022-3	2017	Peptidomic analysis by LC-ESI-MS/MS revealed that Ile, Leu, Tyr, and Phe residues near the C-terminus of beta-casein were the main sites of cleavage by the residual proteases, generating assumed bitter peptides.	Isoleucine	50-53	casein beta	Homo sapiens	105-116
28770939-4	2017	Some structural elements, including stereochemistry around the cyclization residues and Ile and Trp side chains in the gp120-binding pharmacophore, exhibited relatively low tolerance for change, reflecting the importance of these components for function.	Isoleucine	88-91	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	119-124
28867816-7	2017	Individually, leucine increased IRS-1 expression, whereas isoleucine and valine decreased FASN expression.	Isoleucine	58-68	fatty acid synthase	Homo sapiens	90-94
28317757-3	2017	Sequences of ACE-inhibitory peptides are composed of hydrophobic (proline) and aliphatic amino acids (isoleucine and leucine) at the N-terminus.	Isoleucine	102-112	angiotensin I converting enzyme	Homo sapiens	13-16
26706905-7	2017	The study suggests that ligand interaction with the residues Asp 48, Thr 44, Thr 77, Tyr 81, Trp29, Ile 143 of NRP-1 and Lys 653, Phe 765, Ser 763, Thr 699, Ile 683 of Eph might be critical for the inhibitory activity of these receptors.	Isoleucine	100-103	EPH receptor A1	Homo sapiens	168-171
28522547-4	2017	In this model, OMR1 exerts primary control on Ile accumulation and functions independently of AHAS and IPMS AHAS and IPMS regulate Val and Leu homeostasis, where AHAS affects total Val+Leu and IPMS controls partitioning between these amino acids.	Isoleucine	46-49	L-O-methylthreonine resistant 1	Arabidopsis thaliana	15-19
27905109-1	2017	Short-chain enoyl-CoA hydratase (SCEH) is a mitochondrial enzyme involved in the oxidation of fatty acids and the catabolic pathway of valine and, to a lesser extent, isoleucine.	Isoleucine	167-177	enoyl-CoA hydratase, short chain 1	Homo sapiens	0-31
27905109-1	2017	Short-chain enoyl-CoA hydratase (SCEH) is a mitochondrial enzyme involved in the oxidation of fatty acids and the catabolic pathway of valine and, to a lesser extent, isoleucine.	Isoleucine	167-177	enoyl-CoA hydratase, short chain 1	Homo sapiens	33-37
28083649-4	2017	A conserved isoleucine-containing motif (NXI) was proposed to be essential for fructose transport capacity of GLUT7 and GLUT9 but also of GLUT2 and GLUT5.	Isoleucine	12-22	solute carrier family 2 member 7	Homo sapiens	110-115
28083649-4	2017	A conserved isoleucine-containing motif (NXI) was proposed to be essential for fructose transport capacity of GLUT7 and GLUT9 but also of GLUT2 and GLUT5.	Isoleucine	12-22	solute carrier family 2 member 9	Homo sapiens	120-125
28083649-4	2017	A conserved isoleucine-containing motif (NXI) was proposed to be essential for fructose transport capacity of GLUT7 and GLUT9 but also of GLUT2 and GLUT5.	Isoleucine	12-22	solute carrier family 2 member 2	Homo sapiens	138-143
28083649-4	2017	A conserved isoleucine-containing motif (NXI) was proposed to be essential for fructose transport capacity of GLUT7 and GLUT9 but also of GLUT2 and GLUT5.	Isoleucine	12-22	solute carrier family 2 member 5	Homo sapiens	148-153
28270562-2	2017	A recent genetic study reported a male infertility case that was directly associated with a point mutation in the PLCzeta C2 domain, where an isoleucine residue had been substituted with a phenylalanine (I489F).	Isoleucine	142-152	phospholipase C zeta 1	Homo sapiens	114-121
28113050-5	2017	At the Leu1 position, only mutations with helix structure-promoting hydrophobic residues (Ala, Ile, Val or Phe) were able to yield the mature Ent53B derivative.	Isoleucine	95-98	CD5 molecule	Homo sapiens	7-11
28413737-2	2017	Recently, a number of studies have revealed that branched-chain amino acids (BCAAs) (leucine, isoleucine, and valine) play an important role in the regulation of protein synthesis by activating mammalian target of rapamycin (mTOR) in pancreatic beta cells.	Isoleucine	94-104	mechanistic target of rapamycin kinase	Homo sapiens	194-223
28413737-2	2017	Recently, a number of studies have revealed that branched-chain amino acids (BCAAs) (leucine, isoleucine, and valine) play an important role in the regulation of protein synthesis by activating mammalian target of rapamycin (mTOR) in pancreatic beta cells.	Isoleucine	94-104	mechanistic target of rapamycin kinase	Homo sapiens	225-229
27809652-12	2017	Within all 64 MZ twin pairs, lower insulin sensitivity associated with higher levels of VLDLs, triglycerides, FAs, and isoleucine.	Isoleucine	119-129	insulin	Homo sapiens	35-42
27829685-7	2017	This mutation predicted a substitution of isoleucine for a highly conserved valine residue in the seventh transmembrane domain of EAAT1.	Isoleucine	42-52	solute carrier family 1 member 3	Homo sapiens	130-135
28381353-6	2017	After a 24-hour incubation period, whey protein hydrolysate, leucine, isoleucine, and valine attenuated the TNF-alpha-induced endothelial inflammation by normalizing TNF and eNOS gene expression.	Isoleucine	70-80	tumor necrosis factor	Homo sapiens	108-117
28381353-6	2017	After a 24-hour incubation period, whey protein hydrolysate, leucine, isoleucine, and valine attenuated the TNF-alpha-induced endothelial inflammation by normalizing TNF and eNOS gene expression.	Isoleucine	70-80	tumor necrosis factor	Homo sapiens	108-111
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Isoleucine	158-168	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	3-8
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Isoleucine	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Isoleucine	158-168	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	146-151
27842798-2	2017	In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine.	Isoleucine	158-168	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
28696843-0	2017	Hb Amsterdam-A1 [alpha32(B13)Met Ile; HBA1: c.99G&gt;A]: A Hyperunstable Variant Due to a New Mutation on the alpha1 Gene.	Isoleucine	33-36	adrenoceptor alpha 1D	Homo sapiens	110-116
28696843-3	2017	We report the identification of such a variant, alpha32(B13)Met Ile; HBA1: c.99G&gt;A, arising from a new mutation on the alpha1 gene.	Isoleucine	64-67	hemoglobin subunit alpha 1	Homo sapiens	69-73
28696843-3	2017	We report the identification of such a variant, alpha32(B13)Met Ile; HBA1: c.99G&gt;A, arising from a new mutation on the alpha1 gene.	Isoleucine	64-67	adrenoceptor alpha 1D	Homo sapiens	122-128
28216637-1	2017	Adenosine-to-inosine RNA editing in transcripts encoding the voltage-gated potassium channel Kv1.1 converts an isoleucine to valine codon for amino acid 400, speeding channel recovery from inactivation.	Isoleucine	111-121	potassium voltage-gated channel subfamily A member 1	Homo sapiens	93-98
28003368-6	2017	We also discovered that UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine (IQ) motif.	Isoleucine	75-85	ubiquitin protein ligase E3B	Homo sapiens	24-29
28003368-6	2017	We also discovered that UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine (IQ) motif.	Isoleucine	75-85	calmodulin 1	Homo sapiens	45-55
29732238-9	2017	We identified initial signature of simvastatin-induced insulin resistance, including ethanolamine, hydroxylamine, hydroxycarbamate and isoleucine which, upon further replication and expansion, could be predictive biomarkers of individual susceptibility to simvastatin-induced new onset pre-type II diabetes mellitus.	Isoleucine	135-145	insulin	Homo sapiens	55-62
27891564-8	2017	The two whole genome sequences from dogs with PxD had a rare homozygous PIGN:c.398C &gt; T transition, which predicted the substitution of an isoleucine for a highly conserved threonine in the encoded enzyme.	Isoleucine	142-152	phosphatidylinositol glycan anchor biosynthesis class N	Canis lupus familiaris	72-76
27693049-0	2016	The antiangiogenic and antitumor activities of the N-terminal fragment of endostatin augmented by Ile/Arg substitution: The overall structure implicated the biological activity.	Isoleucine	98-101	collagen type XVIII alpha 1 chain	Homo sapiens	74-84
27590064-3	2016	Based on the sequence homology, Exo70A1 is divided into four subdomains: leucine zipper (Leu(128)-Leu(149)), hypervariable region (Ser(172)-Leu(197)), SUMO modification motif (Glu(260)-Ile(275)), and pfamExo70 domain (His(271)-Phe(627)).	Isoleucine	185-188	exocyst complex component EXO70A1	Brassica oleracea	32-39
27555325-6	2016	We found that PA residue isoleucine 656 plays a critical role in PA binding to TEM8 but has a much lesser effect on PA binding to CMG2.	Isoleucine	25-35	anthrax toxin receptor 1	Mus musculus	79-83
27713539-3	2016	Human-rat transporter chimeras revealed that human URAT1 serine-35, phenylalanine-365 and isoleucine-481 are necessary and sufficient to provide up to a 100-fold increase in affinity for inhibitors.	Isoleucine	90-100	solute carrier family 22 member 12	Homo sapiens	51-56
27649793-3	2016	Egg white ovotransferrin-derived tripeptide IRW (Ile-Arg-Trp) was previously shown to exert antihypertensive effect by reducing Ang II synthesis as well as endothelial cell inflammation and endothelial dysfunction.	Isoleucine	49-52	angiotensinogen	Homo sapiens	128-134
26790401-7	2016	Dietary supplementation with tryptophan, valine and isoleucine in low CP diets increased ADG (linear and quadratic effect, P &lt; 0.05), serum levels of valine (quadratic effect, P &lt; 0.05) and isoleucine (linear and quadratic effect, P &lt; 0.05) and immunoglobulin G (IgG) and IgA (linear and quadratic effect, P &lt; 0.05) in finishing gilts.	Isoleucine	52-62	IGG	Sus scrofa	254-284
27867938-2	2016	We previously identified a mutation in NPAS3 that results in a valine to isoleucine (V304I) amino acid substitution segregating with schizophrenia in a small family.	Isoleucine	73-83	neuronal PAS domain protein 3	Homo sapiens	39-44
27440890-4	2016	Mutational analyses of UL51 showed that UL51 amino acid residues Leu-111, Ile-119, and Tyr-123 were required for interaction with UL14 in HSV-1-infected cells.	Isoleucine	74-77	tegument protein UL51	Human alphaherpesvirus 1	23-27
27440890-4	2016	Mutational analyses of UL51 showed that UL51 amino acid residues Leu-111, Ile-119, and Tyr-123 were required for interaction with UL14 in HSV-1-infected cells.	Isoleucine	74-77	tegument protein UL14	Human alphaherpesvirus 1	130-134
27708262-5	2016	The KIR3DL1/KIR3DS1 alleles were also present at similar frequencies among cases and controls bearing HLA-B with a Bw4 motif; HLA-B with a Bw4 motif with isoleucine at position 80; and HLA-B*51.	Isoleucine	154-164	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	4-11
27708262-5	2016	The KIR3DL1/KIR3DS1 alleles were also present at similar frequencies among cases and controls bearing HLA-B with a Bw4 motif; HLA-B with a Bw4 motif with isoleucine at position 80; and HLA-B*51.	Isoleucine	154-164	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	Homo sapiens	12-19
27988858-4	2016	Here we report the assignment of the isoleucine, leucine, methionine and valine methyl groups of the four SNARE motifs of syntaxin-1, SNAP-25 and synaptobrevin within the SNARE complex based solely on measurements of lanthanide-induced pseudocontact shifts.	Isoleucine	37-47	synaptosome associated protein 25	Homo sapiens	134-141
27655440-13	2016	The mechanisms underlying glucose lowering appear to differ; leucine stimulated insulin, whereas isoleucine acted insulin independently.	Isoleucine	97-107	insulin	Homo sapiens	114-121
27701820-5	2016	Using this approach, we revealed interactions between tyrosine residues of a 27-residue peptide (deuterated at Ile and Val residues) corresponding to the N-terminal segment of the human C-C chemokine receptor 5 (CCR5) chemokine receptor, and a 43 kDa construct of gp120 envelope protein of human immunodeficiency virus type 1 (deuterated on all aromatics) complexed with a cluster of differentiation 4-mimic miniprotein.	Isoleucine	111-114	C-C motif chemokine receptor 5	Homo sapiens	186-210
27701820-5	2016	Using this approach, we revealed interactions between tyrosine residues of a 27-residue peptide (deuterated at Ile and Val residues) corresponding to the N-terminal segment of the human C-C chemokine receptor 5 (CCR5) chemokine receptor, and a 43 kDa construct of gp120 envelope protein of human immunodeficiency virus type 1 (deuterated on all aromatics) complexed with a cluster of differentiation 4-mimic miniprotein.	Isoleucine	111-114	C-C motif chemokine receptor 5	Homo sapiens	212-216
27701820-5	2016	Using this approach, we revealed interactions between tyrosine residues of a 27-residue peptide (deuterated at Ile and Val residues) corresponding to the N-terminal segment of the human C-C chemokine receptor 5 (CCR5) chemokine receptor, and a 43 kDa construct of gp120 envelope protein of human immunodeficiency virus type 1 (deuterated on all aromatics) complexed with a cluster of differentiation 4-mimic miniprotein.	Isoleucine	111-114	C-X-C motif chemokine receptor 4	Homo sapiens	190-208
27701820-7	2016	The TRNOE crosspeaks in the ternary complex were assigned to the specific Tyr protons in the CCR5 peptide and to methyl protons, predominantly of isoleucine residues, and also of leucine and/or valine residues of gp120.	Isoleucine	146-156	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	213-218
26520451-0	2016	Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels.	Isoleucine	67-70	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	98-101
26520451-1	2016	The effect of the conserved Leu/Ile site in the CD loop on the gating dynamics of Kir channels and corresponding micro-structural mechanism remains unclear.	Isoleucine	32-35	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	82-85
27749147-8	2016	In nodules of two sacpd-c mutants, the combined jasmonic acid (JA) species (JA and the isoleucine conjugate of JA) were found to be reduced and 12-oxophytodienoic acid (OPDA) levels were significantly higher relative to wild-type lines.	Isoleucine	87-97	stearoyl-ACP desaturase	Glycine max	18-25
27490818-1	2016	BACKGROUND: The proteinogenic branched-chain amino acids (BCAAs) valine, leucine and isoleucine might play an unrecognised crucial role in the development of depression through their activation of the mammalian target of rapamycin (mTor) pathway.	Isoleucine	85-95	mechanistic target of rapamycin kinase	Homo sapiens	201-230
27467192-3	2016	However, using 1,5-DAN generates mainly c- and z-series ions by N-Calpha bond cleavage, which makes it difficult to distinguish leucine (Leu) and isoleucine (Ile), and frequently lacks c(n-1)-series ions owing to proline (Pro) at residues n. Several oxidizing matrices generating a- and x-series ions accompanied by d-series ions by Calpha-C bond cleavage have been reported, but an issue remained concerning their sensitivity.	Isoleucine	146-156	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
27490818-1	2016	BACKGROUND: The proteinogenic branched-chain amino acids (BCAAs) valine, leucine and isoleucine might play an unrecognised crucial role in the development of depression through their activation of the mammalian target of rapamycin (mTor) pathway.	Isoleucine	85-95	mechanistic target of rapamycin kinase	Homo sapiens	232-236
26954163-10	2016	Maximum concentrations of isoleucine, phenylalanine, and histidine were noticed in goat milk caseins.	Isoleucine	26-36	Weaning weight-maternal milk	Bos taurus	88-92
27188525-0	2016	Structure-function characterization of the human mitochondrial thiamin pyrophosphate transporter (hMTPPT; SLC25A19): Important roles for Ile(33), Ser(34), Asp(37), His(137) and Lys(291).	Isoleucine	137-140	solute carrier family 25 member 19	Homo sapiens	106-114
27464458-0	2016	Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2.	Isoleucine	11-21	solute carrier family 2 member 1	Homo sapiens	103-108
27464458-0	2016	Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2.	Isoleucine	11-21	solute carrier family 2 member 4	Homo sapiens	113-118
27464458-0	2016	Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2.	Isoleucine	11-21	solute carrier family 5 member 1	Homo sapiens	161-189
27464458-2	2016	Isoleucine has been reported to participate in regulation of glucose levels in many studies; therefore, this study was designed to examine the effect of isoleucine on intestinal and muscular GLUT expressions.	Isoleucine	0-10	solute carrier family 2 member 1	Homo sapiens	191-195
27464458-4	2016	Supplementation of isoleucine in the diet significantly increased piglet average daily gain, enhanced GLUT1 expression in red muscle and GLUT4 expression in red muscle, white muscle and intermediate muscle (P&lt;0 05).	Isoleucine	19-29	solute carrier family 2 member 1	Homo sapiens	102-107
27464458-4	2016	Supplementation of isoleucine in the diet significantly increased piglet average daily gain, enhanced GLUT1 expression in red muscle and GLUT4 expression in red muscle, white muscle and intermediate muscle (P&lt;0 05).	Isoleucine	19-29	solute carrier family 2 member 4	Homo sapiens	137-142
27464458-7	2016	In C2C12 cells supplemented with isoleucine in the medium, cellular 2-deoxyglucose uptake was increased (P&lt;0 05) through enhancement of the expressions of GLUT4 and GLUT1 (P&lt;0 05).	Isoleucine	33-43	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	158-163
27464458-7	2016	In C2C12 cells supplemented with isoleucine in the medium, cellular 2-deoxyglucose uptake was increased (P&lt;0 05) through enhancement of the expressions of GLUT4 and GLUT1 (P&lt;0 05).	Isoleucine	33-43	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Mus musculus	168-173
27464458-10	2016	The results of this study demonstrated that isoleucine supplementation enhanced the intestinal and muscular GLUT expressions, which have important implications that suggest that isoleucine could potentially increase muscle growth and intestinal development by enhancing local glucose uptake in animals and human beings.	Isoleucine	44-54	solute carrier family 2 member 1	Homo sapiens	108-112
27236753-8	2016	Whereas mTOR was not very sensitive to changes in insulin or acetate levels, it was highly sensitive to leucine and isoleucine, and this signal appeared to be effectively transduced to casein synthesis.	Isoleucine	116-126	mechanistic target of rapamycin kinase	Homo sapiens	8-12
27080133-6	2016	We show that these interactions are affected by the valine-to-isoleucine amino acid substitutions and suppress Myb activity by interfering with the interaction of Myb and the KIX domain of p300.	Isoleucine	62-72	MYB proto-oncogene, transcription factor	Homo sapiens	111-114
27080133-6	2016	We show that these interactions are affected by the valine-to-isoleucine amino acid substitutions and suppress Myb activity by interfering with the interaction of Myb and the KIX domain of p300.	Isoleucine	62-72	MYB proto-oncogene, transcription factor	Homo sapiens	163-166
27080133-6	2016	We show that these interactions are affected by the valine-to-isoleucine amino acid substitutions and suppress Myb activity by interfering with the interaction of Myb and the KIX domain of p300.	Isoleucine	62-72	E1A binding protein p300	Homo sapiens	189-193
29235833-5	2016	Molecular mass of lipoxygenase is 90 kDa, amino acid composition is distinguished by a high content of glutamic acid, proline, valine, isoleucine, leucine and low level of histidine, tyrosine, phenylalanine, threonine, tryptophan, cystein.	Isoleucine	135-145	LOC543232	Triticum aestivum	18-30
27553890-8	2016	On genetic testing a heterogenous 163G &gt; A substitution changing a valine to isoleucine in LIM domain binding protein 3 (LDB3) was identified.	Isoleucine	80-90	LIM domain binding 3	Homo sapiens	94-122
27553890-8	2016	On genetic testing a heterogenous 163G &gt; A substitution changing a valine to isoleucine in LIM domain binding protein 3 (LDB3) was identified.	Isoleucine	80-90	LIM domain binding 3	Homo sapiens	124-128
27472223-5	2016	The protein encoded by Bckdk is an integral part of an enzyme complex located in the mitochondrial matrix of many tissues which regulates the levels of the branched-chain amino acids (BCAAs), leucine, isoleucine and valine.	Isoleucine	201-211	branched chain ketoacid dehydrogenase kinase	Rattus norvegicus	23-28
27217545-6	2016	Using a JA-Ile sensor we demonstrated that activation of JA signaling by salt stress occurs in the meristematic zone and stele of the differentiation zone and that this activation was dependent on JAR1 and proteasome functions.	Isoleucine	11-14	Auxin-responsive GH3 family protein	Arabidopsis thaliana	197-201
27129207-8	2016	Functional characterization of TSHR mutants confirms the previously suggested close proximity of Ser-281 and Ile-486 within the TSHR.	Isoleucine	109-112	thyroid stimulating hormone receptor	Homo sapiens	31-35
27129207-8	2016	Functional characterization of TSHR mutants confirms the previously suggested close proximity of Ser-281 and Ile-486 within the TSHR.	Isoleucine	109-112	thyroid stimulating hormone receptor	Homo sapiens	128-132
26874668-2	2016	The substitution of methionine with isoleucine (M121I) in the cytochrome b (CYTb) gene of B. gibsoni was identified as being associated with atovaquone resistance.	Isoleucine	36-46	cytochrome b	Canis lupus familiaris	62-74
26888582-7	2016	The physical effect of the 3619A &gt;G mutation was found to be the replacement of the threonine residue with alanine, and that of mutation 4006G &gt;A was the replacement of the valine residue with isoleucine in the BRCA1 protein.	Isoleucine	199-209	BRCA1 DNA repair associated	Canis lupus familiaris	217-222
32263314-3	2016	To this end, we prepared and characterized the matrix metalloprotease-2 (MMP-2)/MMP-9-sensitive linker of the proline-valine-glycine-leucine-isoleucine-glycine (Pro-Val-Gly-Leu-Ile-Gly, PVGLIG) oligopeptide via a convenient and fast liquid-phase synthesis.	Isoleucine	141-151	matrix metallopeptidase 2	Mus musculus	47-71
27338465-8	2016	The postprandial changes in isoleucine and gamma-aminobutyric acid (GABA) during the OGTT were positively associated with the homeostasis model assessment of insulin resistance (HOMA-IR; all p &lt; 0.05) in the HLP group.	Isoleucine	28-38	insulin	Homo sapiens	158-165
32263314-3	2016	To this end, we prepared and characterized the matrix metalloprotease-2 (MMP-2)/MMP-9-sensitive linker of the proline-valine-glycine-leucine-isoleucine-glycine (Pro-Val-Gly-Leu-Ile-Gly, PVGLIG) oligopeptide via a convenient and fast liquid-phase synthesis.	Isoleucine	141-151	matrix metallopeptidase 2	Mus musculus	73-78
32263314-3	2016	To this end, we prepared and characterized the matrix metalloprotease-2 (MMP-2)/MMP-9-sensitive linker of the proline-valine-glycine-leucine-isoleucine-glycine (Pro-Val-Gly-Leu-Ile-Gly, PVGLIG) oligopeptide via a convenient and fast liquid-phase synthesis.	Isoleucine	141-151	matrix metallopeptidase 9	Mus musculus	80-85
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Isoleucine	64-67	fibroblast growth factor 14	Homo sapiens	92-97
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Isoleucine	64-67	fibroblast growth factor 14	Homo sapiens	105-110
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Isoleucine	64-67	sodium voltage-gated channel alpha subunit 8	Homo sapiens	111-117
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Isoleucine	64-67	fibroblast growth factor 14	Homo sapiens	105-110
26994141-6	2016	Additional analysis revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14 Nav1.6 complex and FGF14:FGF14 dimer formation.	Isoleucine	64-67	fibroblast growth factor 14	Homo sapiens	105-110
27083206-4	2016	In IPEC-J2 cells, isoleucine, leucine, and valine could stimulate beta-defensin expression, possibly associated with stimulation of ERK1/2 phosphorylation.	Isoleucine	18-28	mitogen-activated protein kinase 3	Sus scrofa	132-138
27083206-5	2016	Inhibition of Sirt1 and ERK completely blocked the activation of ERK and 90RSK protein by isoleucine, simultaneously decreasing defensin expression.	Isoleucine	90-100	sirtuin 1	Homo sapiens	14-19
27083206-5	2016	Inhibition of Sirt1 and ERK completely blocked the activation of ERK and 90RSK protein by isoleucine, simultaneously decreasing defensin expression.	Isoleucine	90-100	mitogen-activated protein kinase 1	Homo sapiens	24-27
27083206-5	2016	Inhibition of Sirt1 and ERK completely blocked the activation of ERK and 90RSK protein by isoleucine, simultaneously decreasing defensin expression.	Isoleucine	90-100	mitogen-activated protein kinase 1	Homo sapiens	65-68
26807988-4	2016	The 3 bp in-frame deletion removes 1 of the 3 adjacent isoleucine residues in transmembrane segment DIVS6 of Nav1.6 (p.Ile1750del).	Isoleucine	55-65	sodium channel, voltage-gated, type VIII, alpha	Mus musculus	109-115
27064538-2	2016	We previously altered the enantioselectivity of tyrosyl-tRNA synthetase (TyrRS) by inserting the editing domain from phenylalanyl-tRNA synthetase (FRSed) between Gly 161 and Ile 162 in tyrosyl-tRNA synthetase (the editing domain hydrolyzes l-Tyr-tRNA but not d-Tyr-tRNA).	Isoleucine	174-177	tyrosyl-tRNA synthetase 1	Homo sapiens	48-71
27064538-2	2016	We previously altered the enantioselectivity of tyrosyl-tRNA synthetase (TyrRS) by inserting the editing domain from phenylalanyl-tRNA synthetase (FRSed) between Gly 161 and Ile 162 in tyrosyl-tRNA synthetase (the editing domain hydrolyzes l-Tyr-tRNA but not d-Tyr-tRNA).	Isoleucine	174-177	tyrosyl-tRNA synthetase 1	Homo sapiens	73-78
27064538-2	2016	We previously altered the enantioselectivity of tyrosyl-tRNA synthetase (TyrRS) by inserting the editing domain from phenylalanyl-tRNA synthetase (FRSed) between Gly 161 and Ile 162 in tyrosyl-tRNA synthetase (the editing domain hydrolyzes l-Tyr-tRNA but not d-Tyr-tRNA).	Isoleucine	174-177	tyrosyl-tRNA synthetase 1	Homo sapiens	185-208
27033407-2	2016	A single-nucleotide polymorphism in the cholesteryl ester transfer protein (CETP) gene (isoleucine to valine; V405) is associated with slower memory decline and a lower risk of Alzheimer"s disease.	Isoleucine	88-98	cholesteryl ester transfer protein	Homo sapiens	40-74
27033407-2	2016	A single-nucleotide polymorphism in the cholesteryl ester transfer protein (CETP) gene (isoleucine to valine; V405) is associated with slower memory decline and a lower risk of Alzheimer"s disease.	Isoleucine	88-98	cholesteryl ester transfer protein	Homo sapiens	76-80
26815332-2	2016	A recent experimental study has shown that the (147)GVIGIAQ(153) SOD1 C-terminal segment not only forms amyloid fibrils in isolation but also accelerates the aggregation of full-length SOD1, while substitution of isoleucine at site 149 by proline blocks its fibril formation.	Isoleucine	213-223	superoxide dismutase 1	Homo sapiens	65-69
27148256-4	2016	The 10 ECs had a classical genomic profile: all of them carried the KIR3DL1 gene and 9 carried at least 1 allele of HLA-B:Bw4-80Ile (i.e., with an isoleucine residue at position 80).	Isoleucine	147-157	major histocompatibility complex, class I, B	Homo sapiens	116-121
26964672-4	2016	Modeling study indicated that the selectivity of our compounds to hMAO-B is determined by at least two residues, i.e., Ile 199 and Cys 172 (or corresponded Phe 208 and Asn 181 of hMAO-A).	Isoleucine	119-122	monoamine oxidase B	Homo sapiens	66-72
26836778-5	2016	From the calculated results we determined that the decrease in the binding affinity between TMC and NS5B(L392I) polymerase is mainly caused by the extra methyl group at the CB atom of Ile.	Isoleucine	184-187	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	92-95
27572445-3	2016	Following delivery into gastric epithelial cells via type IV secretion(7,8), the cagA-encoded CagA protein undergoes tyrosine phosphorylation on the Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs initially by Src family kinases (SFKs) and then by c-Abl(9,10).	Isoleucine	157-160	S100 calcium binding protein A8	Homo sapiens	81-85
27020034-5	2016	A highly conserved Thr residue of PaO was mutated into Ile in the eas1 mutant.	Isoleucine	55-58	Pheophorbide a oxygenase family protein with Rieske 2Fe-2S domain-containing protein	Arabidopsis thaliana	34-37
27572445-3	2016	Following delivery into gastric epithelial cells via type IV secretion(7,8), the cagA-encoded CagA protein undergoes tyrosine phosphorylation on the Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs initially by Src family kinases (SFKs) and then by c-Abl(9,10).	Isoleucine	157-160	S100 calcium binding protein A8	Homo sapiens	94-98
27642608-1	2016	Recent studies have shown the positive association between increased circulating BCAAs (valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients.	Isoleucine	109-119	insulin	Homo sapiens	125-132
26517995-1	2016	The action mode of sulfonylurea herbicides is the inhibition of the acetohydroxyacid synthase (AHAS) required for the biosynthesis of amino acids valine and isoleucine in plants.	Isoleucine	157-167	ilvB acetolactate synthase like	Homo sapiens	68-93
26517995-1	2016	The action mode of sulfonylurea herbicides is the inhibition of the acetohydroxyacid synthase (AHAS) required for the biosynthesis of amino acids valine and isoleucine in plants.	Isoleucine	157-167	ilvB acetolactate synthase like	Homo sapiens	95-99
27303701-8	2016	Under lysine or isoleucine-valine deprivation conditions, Gcn4 recruitment to LYS2 and LYS9 promoters was induced in C. albicans.	Isoleucine	16-26	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	58-62
26646023-12	2016	ILE rapidly phosphorylated Akt at S473 and T308 to 150 +- 23% and 167 +- 10% of baseline, respectively, but did not interfere with AMPK or targets of mammalian target of rapamycin complex 1.	Isoleucine	0-3	AKT serine/threonine kinase 1	Homo sapiens	27-30
29052469-0	2016	Vitamin D and L-Isoleucine Promote Antimicrobial Peptide hBD-2 Production in Peripheral Blood Mononuclear Cells from Elderly Individuals.	Isoleucine	14-26	defensin beta 4A	Homo sapiens	57-62
29052469-3	2016	L-isoleucine and vitamin D are important molecules that induce hBD-2.	Isoleucine	0-12	defensin beta 4A	Homo sapiens	63-68
29052469-4	2016	The Aim of this study was to determine the use L-isoleucine and Vitamin D to induce hBD-2 in cells from healthy elderly individuals and elderly individuals with recurrent infections.	Isoleucine	47-59	defensin beta 4A	Homo sapiens	84-89
26669414-3	2016	In this study, we describe the discovery and characterization of two enzyme pairs consisting of a pyridoxal 5"-phosphate (PLP)-linked aminotransferase and an unprecedented isomerase synergistically responsible for the biosynthesis of L-allo-Ile from L-isoleucine (L-Ile) in natural products.	Isoleucine	250-262	pyridoxal phosphatase	Homo sapiens	122-125
26669414-3	2016	In this study, we describe the discovery and characterization of two enzyme pairs consisting of a pyridoxal 5"-phosphate (PLP)-linked aminotransferase and an unprecedented isomerase synergistically responsible for the biosynthesis of L-allo-Ile from L-isoleucine (L-Ile) in natural products.	Isoleucine	264-269	pyridoxal phosphatase	Homo sapiens	122-125
26643219-5	2015	ILE 193 of alpha1A was validated as the key residues for binding ligand.	Isoleucine	0-3	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	11-18
26399631-8	2015	We also discovered a novel K27M mutation in HIST2H3C, and a lysine-to-isoleucine substitution (K27I) in H3F3A, also creating a loss of trimethylation.	Isoleucine	70-80	H3.3 histone A	Homo sapiens	104-109
26048794-3	2015	Molecular docking analyses demonstrated that an isoleucine residue in the active site of COX1 is responsible for lower affinity to COX1 and increased potency towards COX2.	Isoleucine	48-58	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	89-93
26500112-9	2015	The key residues involved in binding of PKI-179 were Ala-805 in PI3Kgamma and Ile-2163 in mTOR as they have lost maximum accessible surface area due to binding.	Isoleucine	78-81	mechanistic target of rapamycin kinase	Homo sapiens	90-94
26345619-7	2015	Further analysis indicated that the combined mutations of Ile 115 and Pro 214, positioned on the lateral surface of the Stp1 N-domain, fully accounted for the enhanced transport activity.	Isoleucine	58-61	Stp1p	Saccharomyces cerevisiae S288C	120-124
26048090-1	2015	Two food-derived ACE inhibitory peptides, Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP), may have potential as alternative treatments for treatment of mild- or pre-hypertension.	Isoleucine	42-45	angiotensin I converting enzyme	Rattus norvegicus	17-20
26216987-4	2015	Here, we provide evidence that the hydrophobic patch of ubiquitin comprising Leu-8 and Ile-44 is important for E6AP-mediated ubiquitination, whereas it does not affect the catalytic properties of the isolated catalytic HECT domain of E6AP.	Isoleucine	87-90	ubiquitin protein ligase E3A	Homo sapiens	111-115
26490558-8	2015	Overall, TLR4 (Thr399Ile) Thr/Ile genotype demonstrated an association with ESRD on PD (OR 3.9).	Isoleucine	21-24	toll like receptor 4	Homo sapiens	9-13
26668776-1	2015	L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Isoleucine	133-143	solute carrier family 7 member 5	Homo sapiens	0-31
26668776-1	2015	L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine, and histidine.	Isoleucine	133-143	solute carrier family 7 member 5	Homo sapiens	33-37
26342079-4	2015	Our study maps the important ISD11 amino acid residues belonging to putative helix 1 (Phe-40), helix 3 (Leu-63, Arg-68, Gln-69, Ile-72, Tyr-76), and C-terminal segment (Leu-81, Glu-84) are critical for in vivo Fe-S cluster biogenesis.	Isoleucine	128-131	LYR motif containing 4	Homo sapiens	29-34
25982730-6	2015	Subsequently, LAP cleaves a bond between isoleucine and AN to liberate a free electroactive AN species.	Isoleucine	41-51	LAP	Homo sapiens	14-17
26138553-7	2015	In contrast, densitometric analysis of autoradiographic images of (125)I-sarcosine(1), isoleucine(8) Ang II binding to AT1 receptors of the injected side RVLM revealed a small (10 %) reduction in AT1-receptor expression compared to the contralateral RVLM.	Isoleucine	87-97	angiotensin II receptor, type 1a	Rattus norvegicus	119-122
26229101-9	2015	Reciprocal mutation of alanine 145, histidine 180, and isoleucine 191 on 14-3-3sigma isoform promotes GluN2C binding and surface expression.	Isoleucine	55-65	glutamate ionotropic receptor NMDA type subunit 2C	Homo sapiens	102-108
25994031-4	2015	This base transversion leads to an Ile-to-Phe amino acid substitution at codon 434 within the CYP2C9 protein, and this new variant has been named a novel allele, CYP2C9*59, by the Human CYP Allele Nomenclature Committee (http://www.cypalleles.ki.se/cyp2c9.htm).	Isoleucine	35-38	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	94-100
25994031-4	2015	This base transversion leads to an Ile-to-Phe amino acid substitution at codon 434 within the CYP2C9 protein, and this new variant has been named a novel allele, CYP2C9*59, by the Human CYP Allele Nomenclature Committee (http://www.cypalleles.ki.se/cyp2c9.htm).	Isoleucine	35-38	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	162-168
25994031-4	2015	This base transversion leads to an Ile-to-Phe amino acid substitution at codon 434 within the CYP2C9 protein, and this new variant has been named a novel allele, CYP2C9*59, by the Human CYP Allele Nomenclature Committee (http://www.cypalleles.ki.se/cyp2c9.htm).	Isoleucine	35-38	peptidylprolyl isomerase G	Homo sapiens	94-97
25994031-4	2015	This base transversion leads to an Ile-to-Phe amino acid substitution at codon 434 within the CYP2C9 protein, and this new variant has been named a novel allele, CYP2C9*59, by the Human CYP Allele Nomenclature Committee (http://www.cypalleles.ki.se/cyp2c9.htm).	Isoleucine	35-38	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	249-255
25861899-2	2015	In this study, we demonstrate the structural basis of isoleucine-induced rigidity towards the strain-driven autoproteolysis at G(-1)S(+1) cleavage site of mucin 1.	Isoleucine	54-64	mucin 1, cell surface associated	Homo sapiens	155-162
26191004-4	2015	The angiotensin II (AngII) AT1 receptor is a prototype GPCR in the study of biased agonism due to the existence of well-known beta-arrestin-biased agonists, such as [Sar(1), Ile(4), Ile(8)]-AngII (SII), and [Sar(1), D-Ala(8)]-AngII (TRV027).	Isoleucine	174-177	angiotensinogen	Homo sapiens	4-18
26191004-4	2015	The angiotensin II (AngII) AT1 receptor is a prototype GPCR in the study of biased agonism due to the existence of well-known beta-arrestin-biased agonists, such as [Sar(1), Ile(4), Ile(8)]-AngII (SII), and [Sar(1), D-Ala(8)]-AngII (TRV027).	Isoleucine	174-177	angiotensinogen	Homo sapiens	20-25
26081110-17	2015	CONCLUSIONS: Despite its activity towards substrates from different metabolic pathways, SCEH appears to be only crucial in valine metabolism, but not in isoleucine metabolism, and only of limited importance for mitochondrial fatty acid oxidation.	Isoleucine	153-163	enoyl-CoA hydratase, short chain 1	Homo sapiens	88-92
25996596-3	2015	Yeast Isu1 with the methionine to isoleucine substitution (M141I), in which the E. coli amino acid is inserted at this position, corrected most of the phenotypes that result from lack of Yfh1 in yeast.	Isoleucine	34-44	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	6-10
25996596-3	2015	Yeast Isu1 with the methionine to isoleucine substitution (M141I), in which the E. coli amino acid is inserted at this position, corrected most of the phenotypes that result from lack of Yfh1 in yeast.	Isoleucine	34-44	ferroxidase	Saccharomyces cerevisiae S288C	187-191
25996596-9	2015	In contrast, expression of IscU with the reverse substitution i.e. IscU with Ile to Met change led to worsening of the  yfh1 phenotypes, including severely compromised growth, increased sensitivity to oxygen, deficiency in Fe-S clusters and heme, and impaired iron homeostasis.	Isoleucine	77-80	ferroxidase	Saccharomyces cerevisiae S288C	120-124
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Isoleucine	160-163	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Isoleucine	243-246	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Isoleucine	243-246	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
26213944-3	2015	A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection.	Isoleucine	48-51	5', 3'-nucleotidase, cytosolic	Homo sapiens	108-111
26132046-0	2015	Structure-Based Assignment of Ile, Leu, and Val Methyl Groups in the Active and Inactive Forms of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 2.	Isoleucine	30-33	mitogen-activated protein kinase 1	Homo sapiens	135-174
26132046-10	2015	This method was applied to the inactive and active forms of the 42-kDa ILV (13)C(1)H3-methyl labeled extracellular signal-regulated kinase 2 (ERK2), leading to assignment of 60% of the methyls, including 90% of Ile residues.	Isoleucine	211-214	mitogen-activated protein kinase 1	Homo sapiens	101-140
26132046-10	2015	This method was applied to the inactive and active forms of the 42-kDa ILV (13)C(1)H3-methyl labeled extracellular signal-regulated kinase 2 (ERK2), leading to assignment of 60% of the methyls, including 90% of Ile residues.	Isoleucine	211-214	mitogen-activated protein kinase 1	Homo sapiens	142-146
25934394-8	2015	The biased agonist [Sar(1),Ile(8)]AngII also showed a preference for the ground state of the WT-AT1 receptor compared with AngII.	Isoleucine	27-30	angiotensinogen	Homo sapiens	34-39
25934394-8	2015	The biased agonist [Sar(1),Ile(8)]AngII also showed a preference for the ground state of the WT-AT1 receptor compared with AngII.	Isoleucine	27-30	angiotensin II receptor type 1	Homo sapiens	96-99
26091171-5	2015	Crystal structures show that each inhibitor contacts an active site Ile residue in bNOS that is Val in the mammalian NOS isoforms.	Isoleucine	68-71	nitric oxide synthase 1	Homo sapiens	83-87
26091171-6	2015	Mutagenesis studies show that the additional nonpolar contacts provided by the Ile in bNOS contribute to tighter binding toward the bacterial enzyme.	Isoleucine	79-82	nitric oxide synthase 1	Homo sapiens	86-90
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Isoleucine	252-255	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	30-35
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Isoleucine	252-255	calcium/calmodulin dependent protein kinase ID	Homo sapiens	105-115
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Isoleucine	252-255	calcium/calmodulin dependent protein kinase I	Homo sapiens	120-130
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Isoleucine	252-255	calcium/calmodulin dependent protein kinase ID	Homo sapiens	216-226
25922070-6	2015	This current study demonstrates that the I335V mutant transports urate similarly to the wild type hSLC2A9; however, Ile-335 is necessary for urate/fructose trans-acceleration exchange to occur.	Isoleucine	116-119	solute carrier family 2 member 9	Homo sapiens	98-105
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	144-147	solute carrier family 2 member 9	Homo sapiens	60-67
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	144-147	solute carrier family 2 member 5	Homo sapiens	72-79
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	144-147	solute carrier family 2 member 1	Homo sapiens	115-122
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	144-147	solute carrier family 2 member 1	Homo sapiens	124-129
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	144-147	solute carrier family 2 member 5	Homo sapiens	182-189
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	171-174	solute carrier family 2 member 5	Homo sapiens	72-79
25680458-4	2015	Crystallization from binary systems composed of equal ratio of two stereoisomers of isoleucine, unveiled the lower solubility of CSS and ARR stereoisomers, while a longer crystallization time of the CSR and ARS stereoisomers allowed proceeding the vanadium-catalyzed epimerization, leading to the subsequent presence of the CSS and ARR stereoisomers in the product obtained.	Isoleucine	84-94	RIEG2	Homo sapiens	207-210
25131383-9	2015	Leucine, valine and isoleucine activated the ALDC.	Isoleucine	20-30	aldC	Lactococcus lactis	45-49
26024233-6	2015	In agreement with the binding studies, HLA-B*57:01 peptide-elution studies performed in the presence of acyclovir revealed an increased number of endogenously bound peptides with a C-terminal isoleucine.	Isoleucine	192-202	major histocompatibility complex, class I, B	Homo sapiens	39-44
26048794-3	2015	Molecular docking analyses demonstrated that an isoleucine residue in the active site of COX1 is responsible for lower affinity to COX1 and increased potency towards COX2.	Isoleucine	48-58	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	131-135
26048794-3	2015	Molecular docking analyses demonstrated that an isoleucine residue in the active site of COX1 is responsible for lower affinity to COX1 and increased potency towards COX2.	Isoleucine	48-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	166-170
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Isoleucine	88-98	C-type lectin domain family 2 member A	Homo sapiens	9-13
25938568-2	2015	Eutherian mammals possess a highly conserved sequence of OXT (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly).	Isoleucine	70-73	oxytocin/neurophysin I prepropeptide	Homo sapiens	57-60
25811613-2	2015	Here, a micellar system employing TfR-specific 7peptide (histidine-alanine-isoleucine-tyrosine- proline-arginine-histidine, HAIYPRH, 7pep) as the targeting moiety was constructed; and its endocytosis, intracellular trafficking as well as influence on TfR expression and in vivo tumor targeting were explored in the MCF-7 tumor model.	Isoleucine	75-85	transferrin receptor	Homo sapiens	34-37
25900452-2	2015	A homology alignment of CYP5A1 with human CYPs indicates that a highly conserved I-helix threonine residue is occupied by an isoleucine at position 346 in CYP5A1.	Isoleucine	125-135	thromboxane A synthase 1	Homo sapiens	24-30
25900452-2	2015	A homology alignment of CYP5A1 with human CYPs indicates that a highly conserved I-helix threonine residue is occupied by an isoleucine at position 346 in CYP5A1.	Isoleucine	125-135	thromboxane A synthase 1	Homo sapiens	155-161
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Isoleucine	88-98	C-type lectin domain family 2 member A	Homo sapiens	129-133
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Isoleucine	88-98	OMA1 zinc metallopeptidase	Homo sapiens	147-151
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Isoleucine	61-71	glutathione S-transferase pi 1	Homo sapiens	50-55
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Isoleucine	61-71	glutathione S-transferase pi 1	Homo sapiens	91-96
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Isoleucine	88-98	killer cell lectin like receptor F2	Homo sapiens	157-162
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Isoleucine	88-98	C-type lectin domain family 2 member A	Homo sapiens	129-133
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Isoleucine	17-27	C-type lectin domain family 2 member A	Homo sapiens	74-78
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Isoleucine	17-27	C-type lectin domain family 2 member A	Homo sapiens	139-143
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Isoleucine	17-27	killer cell lectin like receptor F2	Homo sapiens	144-149
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Isoleucine	17-27	C-type lectin domain family 2 member A	Homo sapiens	139-143
25736571-8	2015	Substitutions of isoleucine at amino acid 1171 in the ALK kinase domain may distinguish which second generation ALK inhibitor will be effective after crizotinib failure.	Isoleucine	17-27	ALK receptor tyrosine kinase	Homo sapiens	54-57
25736571-8	2015	Substitutions of isoleucine at amino acid 1171 in the ALK kinase domain may distinguish which second generation ALK inhibitor will be effective after crizotinib failure.	Isoleucine	17-27	ALK receptor tyrosine kinase	Homo sapiens	112-115
25490258-5	2015	APC3"s TPR motifs recruit substrate-binding coactivators, CDC20 and CDH1, via their C-terminal conserved Ile-Arg (IR) tail sequences.	Isoleucine	105-108	cell division cycle 27	Homo sapiens	0-4
25925006-7	2015	ILV1 encodes threonine ammonia-lyase, the enzyme that converts threonine to 2-ketobutanoate, a precursor for isoleucine biosynthesis.	Isoleucine	109-119	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	0-4
25490258-5	2015	APC3"s TPR motifs recruit substrate-binding coactivators, CDC20 and CDH1, via their C-terminal conserved Ile-Arg (IR) tail sequences.	Isoleucine	105-108	cell division cycle 20	Homo sapiens	58-63
25490258-5	2015	APC3"s TPR motifs recruit substrate-binding coactivators, CDC20 and CDH1, via their C-terminal conserved Ile-Arg (IR) tail sequences.	Isoleucine	105-108	cadherin 1	Homo sapiens	68-72
25767113-10	2015	These results show that a limited amino acid sequence is responsible for SCH-C specificity to CCR5, and we propose a model showing the interaction with CCR5 Ile(198).	Isoleucine	157-160	C-C motif chemokine receptor 5	Homo sapiens	94-98
25767113-10	2015	These results show that a limited amino acid sequence is responsible for SCH-C specificity to CCR5, and we propose a model showing the interaction with CCR5 Ile(198).	Isoleucine	157-160	C-C motif chemokine receptor 5	Homo sapiens	152-156
25768024-7	2015	Our results suggest that the heterozygous Thr/Ile genotype at the HNMT-Thr105Ile locus and the minor Ile105 allele protect against PD and SCZ in Han Chinese.	Isoleucine	46-49	histamine N-methyltransferase	Homo sapiens	66-70
26005978-10	2015	-GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003.	Isoleucine	7-10	glutathione S-transferase pi 1	Homo sapiens	1-6
26005978-10	2015	-GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003.	Isoleucine	11-14	glutathione S-transferase pi 1	Homo sapiens	1-6
25595958-10	2015	This mutation resulted in an amino acid change from isoleucine to serine that was predicted to lead to tertiary structural alterations that would disrupt the function of the GJB1 protein.	Isoleucine	52-62	gap junction protein beta 1	Homo sapiens	174-178
25382260-3	2015	The QM/MM simulations show that when the original isoleucine residue is substituted in silico by valine, alanine, or glycine (I14V, I14A, and I14G DHFR, respectively), the free energy barrier height of the hydride transfer reaction increases relative to the wild-type enzyme.	Isoleucine	50-60	dihydrofolate reductase	Homo sapiens	147-151
25625371-3	2015	Cow milk opioid peptides, including beta-casomorphin-7 (BCM7, Tyr-Pro-Phe-Pro-Gly-Pro-Ile), affect the mu-opioid receptor (MOR) and are subjected to degradation resulting from the proline dipeptidyl peptidase IV (DPPIV, EC 3.4.14.5) enzyme activity.	Isoleucine	85-89	opioid receptor mu 1	Homo sapiens	123-126
25561730-5	2015	The molecular modeling study showed that Ile(196) at transmembrane helix 2, Met(233) at ECL1, and Asn(302) at ECL2 of GLP1R have contacts with His(1) and Thr(7) of GLP-1.	Isoleucine	41-44	glucagon like peptide 1 receptor	Homo sapiens	118-123
25561730-5	2015	The molecular modeling study showed that Ile(196) at transmembrane helix 2, Met(233) at ECL1, and Asn(302) at ECL2 of GLP1R have contacts with His(1) and Thr(7) of GLP-1.	Isoleucine	41-44	glucagon	Homo sapiens	164-169
25572401-7	2015	The presence of Phe(167) was correlated with a higher tendency toward oligomerization, and its replacement with isoleucine significantly reduced the SDS-resistant dimer formation and cellular functions of syndecan-2 (e.g. cell migration).	Isoleucine	112-122	syndecan 2	Homo sapiens	205-215
25572401-8	2015	Conversely, replacement of isoleucine with phenylalanine at this position in the syndecan-4 TMD rescued the defects observed in a mutant syndecan-2 harboring the syndecan-4 TMD.	Isoleucine	27-37	syndecan 4	Homo sapiens	81-91
25572401-8	2015	Conversely, replacement of isoleucine with phenylalanine at this position in the syndecan-4 TMD rescued the defects observed in a mutant syndecan-2 harboring the syndecan-4 TMD.	Isoleucine	27-37	syndecan 2	Homo sapiens	137-147
25572401-8	2015	Conversely, replacement of isoleucine with phenylalanine at this position in the syndecan-4 TMD rescued the defects observed in a mutant syndecan-2 harboring the syndecan-4 TMD.	Isoleucine	27-37	syndecan 4	Homo sapiens	162-172
25651059-7	2015	The triple helix crosses the junction of blades I and II at a 45  angle to the symmetry axis of the HPX domain, placing the scissile Gly~Ile bond near the HPX domain and shifted ~25 A from MMP-1 complexes.	Isoleucine	137-140	matrix metallopeptidase 1	Homo sapiens	189-194
25646328-0	2015	Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes.	Isoleucine	0-10	patatin like phospholipase domain containing 3	Homo sapiens	64-70
25626607-1	2015	The novel allele HLA-B*15:320 differs from HLA-B*15:01:01:01 at position 709 in exon 4 (A&gt;T, Ile&gt;Phe).	Isoleucine	96-99	major histocompatibility complex, class I, B	Homo sapiens	17-22
25595103-11	2015	Docking of orphan human cytochrome P450 4X1 with arachidonic acid revealed that TYR 112, ALA 126, ILE 222, ILE 223, THR 312, LEU 315, ALA 316, ASP 319, THR 320, PHE 491 and ILE 492 residues were actively participating in the interaction, while docking of CYP4X1 with anandamide showed that TYR 112, GLN 114, PRO 118, ALA 126, ILE 222, ILE 223, SER 251, LEU 315, ALA 316 and PHE 491 key residues were involved in strong interaction.	Isoleucine	98-101	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	24-43
25595103-11	2015	Docking of orphan human cytochrome P450 4X1 with arachidonic acid revealed that TYR 112, ALA 126, ILE 222, ILE 223, THR 312, LEU 315, ALA 316, ASP 319, THR 320, PHE 491 and ILE 492 residues were actively participating in the interaction, while docking of CYP4X1 with anandamide showed that TYR 112, GLN 114, PRO 118, ALA 126, ILE 222, ILE 223, SER 251, LEU 315, ALA 316 and PHE 491 key residues were involved in strong interaction.	Isoleucine	107-110	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	24-43
25595103-11	2015	Docking of orphan human cytochrome P450 4X1 with arachidonic acid revealed that TYR 112, ALA 126, ILE 222, ILE 223, THR 312, LEU 315, ALA 316, ASP 319, THR 320, PHE 491 and ILE 492 residues were actively participating in the interaction, while docking of CYP4X1 with anandamide showed that TYR 112, GLN 114, PRO 118, ALA 126, ILE 222, ILE 223, SER 251, LEU 315, ALA 316 and PHE 491 key residues were involved in strong interaction.	Isoleucine	107-110	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	24-43
25595103-11	2015	Docking of orphan human cytochrome P450 4X1 with arachidonic acid revealed that TYR 112, ALA 126, ILE 222, ILE 223, THR 312, LEU 315, ALA 316, ASP 319, THR 320, PHE 491 and ILE 492 residues were actively participating in the interaction, while docking of CYP4X1 with anandamide showed that TYR 112, GLN 114, PRO 118, ALA 126, ILE 222, ILE 223, SER 251, LEU 315, ALA 316 and PHE 491 key residues were involved in strong interaction.	Isoleucine	107-110	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	24-43
25595103-11	2015	Docking of orphan human cytochrome P450 4X1 with arachidonic acid revealed that TYR 112, ALA 126, ILE 222, ILE 223, THR 312, LEU 315, ALA 316, ASP 319, THR 320, PHE 491 and ILE 492 residues were actively participating in the interaction, while docking of CYP4X1 with anandamide showed that TYR 112, GLN 114, PRO 118, ALA 126, ILE 222, ILE 223, SER 251, LEU 315, ALA 316 and PHE 491 key residues were involved in strong interaction.	Isoleucine	107-110	cytochrome P450 family 4 subfamily X member 1	Homo sapiens	24-43
25480565-2	2015	Although Bw4 residues Ile(80) and Arg(83) directly interact with KIR3DL1*001, their precise role in determining KIR3DL1-HLA-Bw4 specificity remains unclear.	Isoleucine	22-25	BW4	Homo sapiens	9-12
25480565-2	2015	Although Bw4 residues Ile(80) and Arg(83) directly interact with KIR3DL1*001, their precise role in determining KIR3DL1-HLA-Bw4 specificity remains unclear.	Isoleucine	22-25	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	65-72
25480565-5	2015	Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the conformation of Glu(76), primarily through a salt bridge between Arg(83) and Glu(76).	Isoleucine	128-131	major histocompatibility complex, class I, B	Homo sapiens	23-28
25480565-5	2015	Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the conformation of Glu(76), primarily through a salt bridge between Arg(83) and Glu(76).	Isoleucine	128-131	major histocompatibility complex, class I, B	Homo sapiens	36-41
25480565-5	2015	Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the conformation of Glu(76), primarily through a salt bridge between Arg(83) and Glu(76).	Isoleucine	128-131	BW4	Homo sapiens	159-162
25480565-7	2015	Mutation of the Bw4 residue Ile(80) also disrupted this salt bridge, providing further insight into the role that position 80 plays in mediating KIR3DL1 recognition.	Isoleucine	28-31	BW4	Homo sapiens	16-19
25480565-7	2015	Mutation of the Bw4 residue Ile(80) also disrupted this salt bridge, providing further insight into the role that position 80 plays in mediating KIR3DL1 recognition.	Isoleucine	28-31	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	145-152
25747199-3	2015	ATP-dependent uptake of isoleucine and histidine by the vacuolar vesicles of an AVT exporter mutant was lost by introducing avt1  mutation.	Isoleucine	24-34	Avt1p	Saccharomyces cerevisiae S288C	124-128
25747199-6	2015	V-ATPase-dependent acidification of the vesicles was declined by the addition of isoleucine or histidine, depending upon Avt1p.	Isoleucine	81-91	Avt1p	Saccharomyces cerevisiae S288C	121-126
25195009-1	2015	BACKGROUND: Beta-ketothiolase deficiency is a rare inborn errors of metabolism (IEM) affecting the catabolism of isoleucine, characterized by severe ketoacidosis in children of 6 to 24months old.	Isoleucine	113-123	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	Homo sapiens	12-29
25477187-3	2015	Five peptides (Ile-Pro-Ile-Gln-Tyr, Trp-Lys, Trp-Pro, Trp-Arg and Trp-Leu), having DPP-IV half maximum inhibitory concentration values (IC50)&lt;60 muM and reported to act through different inhibition mechanisms, were investigated.	Isoleucine	15-18	dipeptidyl peptidase 4	Homo sapiens	83-89
25409575-10	2015	TREK-1 contains isoleucine in the corresponding position.	Isoleucine	16-26	potassium channel, subfamily K, member 2	Mus musculus	0-6
25551524-1	2015	BACKGROUND: Approximately 4% of black Americans carry a valine-to-isoleucine substitution (V122I) in the transthyretin protein, which has been associated with late-onset restrictive amyloid cardiomyopathy and increased risks of death and heart failure.	Isoleucine	66-76	transthyretin	Homo sapiens	105-118
25435955-7	2015	According to the SIFT and PolyPhen-2 algorithms, the substitution of Ile to Met was predicted to decrease the activity of the MLH1 protein.	Isoleucine	69-72	mutL homolog 1	Homo sapiens	126-130
25288083-5	2014	These structures highlight that interactions with Leu 28, Ile 50, Ile 94, and Leu 54 are necessary for potency; comparison with structures of human DHFR bound to the same inhibitors reveal differences in residues (N64E, P61G, F31L, and V115I) and loop conformations (residues 49 to 53) that may be exploited for selectivity.	Isoleucine	58-61	dihydrofolate reductase	Homo sapiens	148-152
25288083-5	2014	These structures highlight that interactions with Leu 28, Ile 50, Ile 94, and Leu 54 are necessary for potency; comparison with structures of human DHFR bound to the same inhibitors reveal differences in residues (N64E, P61G, F31L, and V115I) and loop conformations (residues 49 to 53) that may be exploited for selectivity.	Isoleucine	66-69	dihydrofolate reductase	Homo sapiens	148-152
25307542-5	2014	MoIlv1 is a homolog of Saccharomyces cerevisiae Ilv1p, which has an important role in the biosynthesis of isoleucine.	Isoleucine	106-116	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	48-53
25654071-5	2014	The genetic analysis of THRbeta confirmed a novel mutation in exon 9; this was a heterozygous C-to-T change in the 327th codon, substituting threonine for isoleucine (T327I).	Isoleucine	155-165	thyroid hormone receptor beta	Homo sapiens	24-31
25211586-5	2014	Furthermore, we found that in African cichlids, NKB peptides differ from other vertebrate NKBs in their C-terminal sequence, possessing isoleucine instead of valine as the X in the NKB FXGLM-NH2-terminal consensus sequence.	Isoleucine	136-146	tachykinin precursor 3	Homo sapiens	48-51
25418972-3	2014	Molecular docking studies demonstrated that Tyr169 and isoleucine 89 (Ile89) may play a role in the inhibitory and/or catalytic positioning of EE2 within the active site of SULT1A1.	Isoleucine	55-65	sulfotransferase family 1A member 1	Homo sapiens	173-180
25318354-2	2014	It differs from HLA-A*68:01:02 at five nucleotides, three intronic, nt 699 T-&gt;G (intron 2), nt 705 T-&gt;C (intron 2) and nt 2770 G-&gt;A (intron 7), and two located in exon 3, at positions 726 A-G (codon 94 Ile-&gt;Val) and 733 T-G (codon 97 Arg-&gt;Met), respectively.	Isoleucine	211-214	major histocompatibility complex, class I, A	Homo sapiens	16-21
25310453-8	2014	We apply similar analysis to oleic acid binding and predict that the Ca(2+)-aLA complex can bind to oleic acid through the basic histidine (H) 32 of the A2 helix and the hydrophobic residues, namely, isoleucine (I) 59, W60 and I95, of the interfacial cleft.	Isoleucine	200-210	lactalbumin alpha	Homo sapiens	76-79
25375834-7	2014	Similarly, a natural substrate of MMP-2, Ace-Gln-Gly ~ Ile-Ala-Gly-Nme, can be converted to an inhibiting compound by two replacements, Ile by Cys and Gly by the d isomer of Cys, favoring formation of the zinc finger motif.	Isoleucine	55-58	matrix metallopeptidase 2	Homo sapiens	34-39
25375834-7	2014	Similarly, a natural substrate of MMP-2, Ace-Gln-Gly ~ Ile-Ala-Gly-Nme, can be converted to an inhibiting compound by two replacements, Ile by Cys and Gly by the d isomer of Cys, favoring formation of the zinc finger motif.	Isoleucine	55-58	angiotensin I converting enzyme	Homo sapiens	41-44
25375834-7	2014	Similarly, a natural substrate of MMP-2, Ace-Gln-Gly ~ Ile-Ala-Gly-Nme, can be converted to an inhibiting compound by two replacements, Ile by Cys and Gly by the d isomer of Cys, favoring formation of the zinc finger motif.	Isoleucine	136-139	matrix metallopeptidase 2	Homo sapiens	34-39
25375834-7	2014	Similarly, a natural substrate of MMP-2, Ace-Gln-Gly ~ Ile-Ala-Gly-Nme, can be converted to an inhibiting compound by two replacements, Ile by Cys and Gly by the d isomer of Cys, favoring formation of the zinc finger motif.	Isoleucine	136-139	angiotensin I converting enzyme	Homo sapiens	41-44
25450372-4	2014	The changes in the inhibitory activities of its Ala mutants, the NMR structure, and molecular simulation results based on other conotoxins targeting nAChR alpha4beta2, all demonstrated that the residues Ile(6) and Leu(14) were the main hydrophobic pharmacophores.	Isoleucine	203-206	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	149-154
25202012-3	2014	The binding to LIMP-2 is not dependent upon a single amino acid, but the interactions of GCase with LIMP-2 are heavily influenced by Asp(399) and the di-isoleucines, Ile(402) and Ile(403).	Isoleucine	166-169	scavenger receptor class B member 2	Homo sapiens	100-106
25202012-3	2014	The binding to LIMP-2 is not dependent upon a single amino acid, but the interactions of GCase with LIMP-2 are heavily influenced by Asp(399) and the di-isoleucines, Ile(402) and Ile(403).	Isoleucine	179-182	scavenger receptor class B member 2	Homo sapiens	100-106
25193673-3	2014	Using molecular dynamics simulations, biochemical assays, and biophysical approaches, we have uncovered an isoleucine residue in the kinase domain of the Tec family member Btk that, when mutated to the closely related leucine, leads to a shift in the conformational equilibrium of the kinase domain toward the active state.	Isoleucine	107-117	Bruton tyrosine kinase	Homo sapiens	172-175
25337708-3	2014	The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3) and L-isoleucine induced HBD-2 and LL-37 in primary cultures from DFU.	Isoleucine	92-104	defensin beta 4A	Homo sapiens	113-118
25337708-3	2014	The aim of this study was to determine whether 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3) and L-isoleucine induced HBD-2 and LL-37 in primary cultures from DFU.	Isoleucine	92-104	cathelicidin antimicrobial peptide	Homo sapiens	123-128
25073461-5	2014	A single nucleotide polymorphism (SNP) for human CHT1 has been identified, which has a replacement from isoleucine to valine in the third transmembrane segment and shows the choline uptake activity of 50-60% as much as that of wild-type CHT1.	Isoleucine	104-114	solute carrier family 5 member 7	Homo sapiens	49-53
25073461-5	2014	A single nucleotide polymorphism (SNP) for human CHT1 has been identified, which has a replacement from isoleucine to valine in the third transmembrane segment and shows the choline uptake activity of 50-60% as much as that of wild-type CHT1.	Isoleucine	104-114	solute carrier family 5 member 7	Homo sapiens	237-241
24390570-1	2014	Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a severe deficiency in the activity of the branched-chain alpha-keto acid dehydrogenase complex, leading to accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine.	Isoleucine	247-257	AT-rich interaction domain 4B	Rattus norvegicus	232-236
25009140-7	2014	The side chains of Trp 4 and Ile 7, and to a lesser extent, those of Lys 2, Trp 3 and Phe 8, form a small hydrophobic cluster.	Isoleucine	29-32	aminoadipate-semialdehyde dehydrogenase	Homo sapiens	69-74
25009140-7	2014	The side chains of Trp 4 and Ile 7, and to a lesser extent, those of Lys 2, Trp 3 and Phe 8, form a small hydrophobic cluster.	Isoleucine	29-32	tRNA-Pro (anticodon TGG) 3-1	Homo sapiens	76-81
24582441-2	2014	The objective of this study was to quantify the rate of alphaS1-casein synthesis in response to Ile, Leu, Met, and Thr supplementation, and to test the single-limiting AA theory for milk protein synthesis by exploring interactions among these AA.	Isoleucine	96-99	casein alpha s1	Bos taurus	56-70
25049229-8	2014	We suggest that a surface of GRK2, including Leu(4), Val(7), Leu(8), Val(11), and Ser(12), directly interacts with receptors, whereas residues such as Asp(10), Tyr(13), Ala(16), Met(17), Gly(475), Val(477), and Ile(485) are more important for kinase domain closure and activation.	Isoleucine	211-214	G protein-coupled receptor kinase 2	Homo sapiens	29-33
24738868-3	2014	Higher isoleucine accumulation in these transgenic tubers suggested that the potatoes compensate for increased methionine biosynthesis with enhanced catabolism via methionine gamma-lyase (MGL), thereby producing 2-ketybutyrate for isoleucine biosynthesis.	Isoleucine	7-17	methionine gamma-lyase	Solanum tuberosum	188-191
24738868-3	2014	Higher isoleucine accumulation in these transgenic tubers suggested that the potatoes compensate for increased methionine biosynthesis with enhanced catabolism via methionine gamma-lyase (MGL), thereby producing 2-ketybutyrate for isoleucine biosynthesis.	Isoleucine	231-241	methionine gamma-lyase	Solanum tuberosum	188-191
25010489-5	2014	BPTI variants carrying Arg, Lys, Ile, Leu or Ala at the P2" position of the binding loop were purified and equilibrium dissociation constants were determined against non-sulfated and sulfated cationic and anionic human trypsins.	Isoleucine	33-36	spleen trypsin inhibitor I	Bos taurus	0-4
24699373-9	2014	Bap2-mediated leucine import was inhibited by some amino acids according to the following order of severity: phenylalanine, leucine&gt;isoleucine&gt;methionine, tyrosine&gt;valine&gt;tryptophan; histidine and asparagine had no effect.	Isoleucine	135-145	branched-chain amino acid permease BAP2	Saccharomyces cerevisiae S288C	0-4
24670082-10	2014	There was a significant correlation between CSF POMC and 10 AA, including leucine, isoleucine, tryptophan, and tyrosine.	Isoleucine	83-93	proopiomelanocortin	Homo sapiens	48-52
24793774-7	2014	DPP-IV inhibitory peptides generally had a hydrophobic or aromatic amino acid at the N-terminus, preferentially a Trp for non-competitive inhibitors and a broader range of residues for competitive inhibitors (Ile, Leu, Val, Phe, Trp or Tyr).	Isoleucine	209-212	dipeptidyl peptidase 4	Homo sapiens	0-6
24684822-4	2014	RESULTS: Valine or isoleucine deprivation for 7 days has similar effect on improving insulin sensitivity as leucine, in wild type and insulin-resistant mice models.	Isoleucine	19-29	insulin	Homo sapiens	85-92
24684822-7	2014	In contrast to leucine withdrawal, valine or isoleucine deprivation for 7 days significantly decreased fed blood glucose levels, possibly due to reduced expression of a key gluconeogenesis gene, glucose-6-phosphatase.	Isoleucine	45-55	glucose-6-phosphatase, catalytic	Mus musculus	195-216
25079372-2	2014	We found that accumulation of the threonine pathway intermediate beta-aspartate semialdehyde (ASA), substrate of homoserine dehydrogenase (Hom6), attenuates the GAAC transcriptional response by accelerating degradation of Gcn4, already an exceedingly unstable protein, in cells starved for isoleucine and valine.	Isoleucine	290-300	homoserine dehydrogenase	Saccharomyces cerevisiae S288C	139-143
24895455-2	2014	The last 3 residues of NaV1.5 (Ser-Ile-Val) constitute a PDZ domain-binding motif that interacts with PDZ proteins such as syntrophins and SAP97 at different locations within the cardiomyocyte, thus defining distinct pools of NaV1.5 multiprotein complexes.	Isoleucine	35-38	sodium voltage-gated channel alpha subunit 5	Homo sapiens	23-29
24895455-2	2014	The last 3 residues of NaV1.5 (Ser-Ile-Val) constitute a PDZ domain-binding motif that interacts with PDZ proteins such as syntrophins and SAP97 at different locations within the cardiomyocyte, thus defining distinct pools of NaV1.5 multiprotein complexes.	Isoleucine	35-38	discs large MAGUK scaffold protein 1	Homo sapiens	139-144
24895455-2	2014	The last 3 residues of NaV1.5 (Ser-Ile-Val) constitute a PDZ domain-binding motif that interacts with PDZ proteins such as syntrophins and SAP97 at different locations within the cardiomyocyte, thus defining distinct pools of NaV1.5 multiprotein complexes.	Isoleucine	35-38	sodium voltage-gated channel alpha subunit 5	Homo sapiens	226-232
25070638-10	2014	These results indicate that plastidial RidA proteins can preempt damage to BCAT3 and Ile biosynthesis by hydrolyzing the Ser-derived enamine/imine product of Thr dehydratase.	Isoleucine	85-88	endoribonuclease L-PSP family protein	Arabidopsis thaliana	39-43
24804563-5	2014	The GalP/GLUT inhibitor forskolin was added to the ILV-labelled sample inducing a pronounced chemical shift change in one Ile residue and more subtle changes in other methyl groups.	Isoleucine	122-125	galanin like peptide	Homo sapiens	4-8
24804563-5	2014	The GalP/GLUT inhibitor forskolin was added to the ILV-labelled sample inducing a pronounced chemical shift change in one Ile residue and more subtle changes in other methyl groups.	Isoleucine	122-125	solute carrier family 2 member 1	Homo sapiens	9-13
24887019-9	2014	Significant association of HLA-Bw4 with isoleucine at amino-acid position 80 (HLA-Bw4-80I) was found in the HLA-B*51(-) German cohort of BD patients [p(c) = 0.0042, OR = 2.35, 95% CI 1.41 to 3.93) and in the Turkish patients in comparison to the respective controls [p = 0.025, OR = 2.17, 95% CI 1.09 to 4.31].	Isoleucine	40-50	BW4	Homo sapiens	31-34
24887019-9	2014	Significant association of HLA-Bw4 with isoleucine at amino-acid position 80 (HLA-Bw4-80I) was found in the HLA-B*51(-) German cohort of BD patients [p(c) = 0.0042, OR = 2.35, 95% CI 1.41 to 3.93) and in the Turkish patients in comparison to the respective controls [p = 0.025, OR = 2.17, 95% CI 1.09 to 4.31].	Isoleucine	40-50	BW4	Homo sapiens	82-85
24887019-9	2014	Significant association of HLA-Bw4 with isoleucine at amino-acid position 80 (HLA-Bw4-80I) was found in the HLA-B*51(-) German cohort of BD patients [p(c) = 0.0042, OR = 2.35, 95% CI 1.41 to 3.93) and in the Turkish patients in comparison to the respective controls [p = 0.025, OR = 2.17, 95% CI 1.09 to 4.31].	Isoleucine	40-50	major histocompatibility complex, class I, B	Homo sapiens	27-32
24463277-7	2014	The BCAT1 enzyme carries out the final step in the biosynthesis and the first step of degradation of the branched-chain amino acids leucine, isoleucine, and valine.	Isoleucine	141-151	branched chain amino acid transaminase 1	Homo sapiens	4-9
24799990-8	2014	Recently, a non-synonymous SNP (rs738409), characterized by a C to G substitution encoding an isoleucine to methionine substitution at the amino acid position 148 in the patatin like phospholipase containing domain 3 gene (PNPLA3), has been associated with hepatic steatosis in a multiethnic cohort of adults as well as in children.	Isoleucine	94-104	patatin like phospholipase domain containing 3	Homo sapiens	223-229
24706822-0	2014	Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2.	Isoleucine	18-28	solute carrier family 10 member 4	Homo sapiens	128-144
24706822-5	2014	In ATP8A2, the corresponding residue is an isoleucine, which recently was found mutated in patients with cerebellar ataxia, mental retardation, and dysequilibrium syndrome.	Isoleucine	43-53	ATPase phospholipid transporting 8A2	Homo sapiens	3-9
24627569-1	2014	BACKGROUND: The 5-amino acid (AA) signature, including isoleucine, leucine, valine, tyrosine, and phenylalanine, has been associated with incident diabetes mellitus and insulin resistance.	Isoleucine	55-65	insulin	Homo sapiens	169-176
24298989-4	2014	TDP-43 expression increased glutamate levels, decreased the levels of other amino acids, including glutamine, aspartate, leucine and isoleucine, and impaired mitochondrial tricarboxylic acid cycle.	Isoleucine	133-143	TAR DNA binding protein	Rattus norvegicus	0-6
24478452-3	2014	Most EB1-binding proteins contain a Ser-any residue-Ile-Pro (SxIP) motif.	Isoleucine	52-55	Eb1	Drosophila melanogaster	5-8
24252724-5	2014	CCl4 also caused a decrease in some of the amino acids such as leucine/isoleucine, glutamine/glutathione and betaine.	Isoleucine	71-81	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
24504338-7	2014	Using an in vitro model replicating the depleted amino acid (AA) composition found within the Emb-LPD uterine luminal fluid, we show TE endocytosis response is activated through reduced branched-chain AAs (leucine, isoleucine, valine).	Isoleucine	215-225	embigin	Mus musculus	94-97
24062162-2	2014	Additional to G11778A mutation, a novel C15620A variant was detected, which resulted in the conversion from leucine to isoleucine in the mitochondrial cytochrome b gene.	Isoleucine	119-129	mitochondrially encoded cytochrome b	Homo sapiens	151-163
24357096-9	2014	RESULTS: The results suggests a protective effect of the genotypes Arg/Lys of AhR rs2066853 (odds ratio [OR] 0.55, p = 0.03), Ile/Val of CYP1A1 rs1048943 (OR 0.49, p = 0.009), Tyr/His of EPHX1 rs1051740 (OR 0.53, p = 0.03), and A/A of CCND1 rs603965 (OR 0.44, p = 0.02).	Isoleucine	126-129	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	137-143
24406630-6	2014	The isoleucine residue at position 254 of HvPIP2;3 was conserved in PIP2 aquaporins of barley, except HvPIP2;4, which possesses methionine instead.	Isoleucine	4-14	HvPIP2;3	Hordeum vulgare	42-50
24328926-13	2014	Furthermore, Ile(116) acts as a gate for the movement of Tyr(244) towards TM-5 in the active state, a mechanism proposed previously for the beta2 -adrenoceptor.	Isoleucine	13-16	adrenoceptor beta 2	Homo sapiens	140-159
24317018-8	2014	A new missense heterozygote mutation, I137M, in SCN5A was found in proband 5 with recurrent palpitations and a high incidence of VT. I137M is in exon 4 of SCN5A, at the S1 segment in domain I of Nav1.5, which predicted a substitution of isoleucine for methionine at codon site 137 (p. Ile137Met, I137M).	Isoleucine	237-247	sodium voltage-gated channel alpha subunit 5	Homo sapiens	48-53
24317018-8	2014	A new missense heterozygote mutation, I137M, in SCN5A was found in proband 5 with recurrent palpitations and a high incidence of VT. I137M is in exon 4 of SCN5A, at the S1 segment in domain I of Nav1.5, which predicted a substitution of isoleucine for methionine at codon site 137 (p. Ile137Met, I137M).	Isoleucine	237-247	sodium voltage-gated channel alpha subunit 5	Homo sapiens	155-160
24317018-8	2014	A new missense heterozygote mutation, I137M, in SCN5A was found in proband 5 with recurrent palpitations and a high incidence of VT. I137M is in exon 4 of SCN5A, at the S1 segment in domain I of Nav1.5, which predicted a substitution of isoleucine for methionine at codon site 137 (p. Ile137Met, I137M).	Isoleucine	237-247	sodium voltage-gated channel alpha subunit 5	Homo sapiens	195-201
23975652-7	2014	These urinary differential metabolites, such as adiponectin, acylcarnitines, citric acid, kynurenic acid, 3-indoxyl sulfate, urate, and glucose, were identified involving several key metabolic pathways such as taurine and hypotaurine metabolism; cysteine and methionine metabolism; valine, leucine, and isoleucine biosynthesis metabolism, etc.	Isoleucine	303-313	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-59
24550275-3	2014	NMR data for the methyl side chains on Ile, Leu, and Val residues showed changes in conformational exchange dynamics in the microsecond-to-millisecond time regime between the different activity states of ERK2.	Isoleucine	39-42	mitogen-activated protein kinase 1	Homo sapiens	204-208
24333853-8	2014	However, substitution of Val231 by the bulkier isoleucine appears to alter enzyme substrate selectivity by decreasing the affinity towards NAT2 substrates and increasing the affinity towards NAT1 substrates.	Isoleucine	47-57	N-acetyltransferase 2	Homo sapiens	139-143
24333853-8	2014	However, substitution of Val231 by the bulkier isoleucine appears to alter enzyme substrate selectivity by decreasing the affinity towards NAT2 substrates and increasing the affinity towards NAT1 substrates.	Isoleucine	47-57	N-acetyltransferase 1	Homo sapiens	191-195
24596454-9	2014	Based on molecular docking studies, we propose that in ACE-1 inhibition IPP and VPP share a similar cis configuration between the first aliphatic (isoleucine or valine) and the second (proline) amino acid residues and more different configurations between two proline residues.	Isoleucine	147-157	angiotensin I converting enzyme	Homo sapiens	55-60
24359813-0	2014	Isoleucine, leucine, methionine, and threonine effects on mammalian target of rapamycin signaling in mammary tissue.	Isoleucine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	58-87
24359813-10	2014	Isoleucine and Thr positively affected mTOR phosphorylation.	Isoleucine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	39-43
24359813-13	2014	In addition, eEF2 phosphorylation was linearly decreased by Ile and Leu.	Isoleucine	60-63	eukaryotic translation elongation factor 2	Homo sapiens	13-17
25674427-8	2014	The rate of decline among peak plasma BCAA concentrations was the highest for leucine, followed by isoleucine and valine.	Isoleucine	99-109	AT-rich interaction domain 4B	Homo sapiens	38-42
24217250-8	2013	Langerin with Asp-288 and Ile-313 shows no binding to 6SO4-Gal-terminated glycans and increased binding to GlcNAc-terminated structures, but overall decreased binding to glycans.	Isoleucine	26-29	CD207 molecule	Homo sapiens	0-8
24399296-8	2014	Furthermore, PS1 cleaved TbetaRI in the transmembrane domain between valine-129 and isoleucine-130, and ICD generation was inhibited when these residues were mutated to alanine.	Isoleucine	84-94	presenilin 1	Mus musculus	13-16
24399296-8	2014	Furthermore, PS1 cleaved TbetaRI in the transmembrane domain between valine-129 and isoleucine-130, and ICD generation was inhibited when these residues were mutated to alanine.	Isoleucine	84-94	transforming growth factor, beta receptor I	Mus musculus	25-32
24273165-3	2014	Homology models of the open and closed states of P2X2 indicate that pore opening is associated with a large lateral displacement of Ile(328).	Isoleucine	132-135	purinergic receptor P2X 2	Homo sapiens	49-53
25274109-9	2014	KEGG pathway annotations using DIANA miRPath or targets predicted by Targetscan identified 7 pathways (Valine, leucine and isoleucine degradation; MAPK signaling pathway; Dorso-ventral axis formation; Propanoate metabolism; Sphingolipid metabolism; Lysine degradation; Jak- STAT signaling pathway) which might be influenced by these miRNAs.	Isoleucine	123-133	p38b MAP kinase	Drosophila melanogaster	147-151
24101201-8	2014	The ara mutant phenotypes can be rescued by exogenously applied Hse, Met, Ile and 2-oxobutanoate.	Isoleucine	74-77	Rab GTPase-like A5A protein	Arabidopsis thaliana	4-7
24129578-4	2013	Substituting the hydrophobic core residues, Leu-331, Val-338, and Ile-345, of Hec1 with alanine completely eliminated Nuf2 binding and blocked mitotic progression.	Isoleucine	66-69	NDC80 kinetochore complex component	Homo sapiens	78-82
24129578-4	2013	Substituting the hydrophobic core residues, Leu-331, Val-338, and Ile-345, of Hec1 with alanine completely eliminated Nuf2 binding and blocked mitotic progression.	Isoleucine	66-69	NUF2 component of NDC80 kinetochore complex	Homo sapiens	118-122
24312436-2	2013	We have previously characterized a tri-peptide IRW (Ile-Arg-Trp) from egg white protein ovotransferrin; this peptide showed anti-inflammatory, anti-oxidant and angiotensin converting enzyme (ACE) inhibitor properties in vitro.	Isoleucine	52-55	angiotensin I converting enzyme	Rattus norvegicus	160-189
24312436-2	2013	We have previously characterized a tri-peptide IRW (Ile-Arg-Trp) from egg white protein ovotransferrin; this peptide showed anti-inflammatory, anti-oxidant and angiotensin converting enzyme (ACE) inhibitor properties in vitro.	Isoleucine	52-55	angiotensin I converting enzyme	Rattus norvegicus	191-194
24097980-7	2013	We also concluded that the increased side chain volume of V280M, in the TM2-TM3 loop, exerts a steric repulsion against Ile-225 at the top of TM1 in the neighboring subunit.	Isoleucine	120-123	tropomyosin 3	Homo sapiens	76-79
24238610-6	2013	Further, we showed that the combination of the amino acid residue Ile at the site 24 with Lys at the site 582 played a positive role in the enzyme activity of LeFRO1.	Isoleucine	66-69	ferric-chelate reductase	Solanum lycopersicum	159-165
23714121-8	2013	Initially, a screening assay for model drug encapsulation in ELP nanoparticles was developed, which showed that Rose Bengal and Rapa have high non-specific encapsulation in the core of ELP nanoparticles with a sequence where Xaa=Ile or Phe.	Isoleucine	229-232	nuclear receptor subfamily 5 group A member 1	Homo sapiens	61-64
23714121-8	2013	Initially, a screening assay for model drug encapsulation in ELP nanoparticles was developed, which showed that Rose Bengal and Rapa have high non-specific encapsulation in the core of ELP nanoparticles with a sequence where Xaa=Ile or Phe.	Isoleucine	229-232	nuclear receptor subfamily 5 group A member 1	Homo sapiens	185-188
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Isoleucine	143-146	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	99-102
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Isoleucine	143-146	cannabinoid receptor 1	Homo sapiens	119-122
24192352-5	2013	HSD is thus a crucial intermediate enzyme linked to the biosynthesis of several essential amino acids such as lysine, methionine, isoleucine and threonine.	Isoleucine	130-140	AT695_RS10950	Staphylococcus aureus	0-3
23382451-8	2013	Changes in beta-hydroxybutyrate, isoleucine, lactate, and pyridoxate were blunted in those with insulin resistance.	Isoleucine	33-43	insulin	Homo sapiens	96-103
25482600-1	2014	Abstract Here, we reported a Chinese case of Creutzfeldt-Jakob disease (CJD) with a rare mutation in the prion protein gene (PRNP) leading to an exchange of amino acid from valine (V) to isoleucine (I) at codon 180 (V180I).	Isoleucine	187-197	prion protein	Homo sapiens	125-129
23900832-5	2013	RESULTS: Overall, allele contrast (Val vs. Ile) of ERBB2 655 polymorphism produced significant results in worldwide populations (OR = 1.123, 95%CI = 1.01-1.249) and in Caucasian populations (OR = 1.149, 95%CI = 1.002-1.318).	Isoleucine	43-46	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-56
24300304-5	2013	This addendum addressed the question whether the increased JA-Ile levels found in coi1 are responsible for its tolerance phenotype.	Isoleucine	62-65	RNI-like superfamily protein	Arabidopsis thaliana	82-86
24300304-6	2013	Based on the evidence that the JA-Ile-deficient dde2-2 coi1-t double mutant is as tolerant as coi1-t, we conclude that increased JA-Ile levels do not protect Arabidopsis against the fungus in the absence of COI1.	Isoleucine	34-37	RNI-like superfamily protein	Arabidopsis thaliana	55-59
24053334-6	2013	Comparisons of structures of human and Staphylococcus aureus DHFR bound to the same PLA reveal a conformational change in the ligand that enhances interactions with residues Phe 92 (Val 115 in huDHFR) and Ile 50 (Ile 60 in huDHFR) in S. aureus DHFR, yielding selectivity.	Isoleucine	205-208	dihydrofolate reductase	Homo sapiens	61-65
24053334-7	2013	Likewise, comparisons of human and Candida glabrata DHFR bound to the same ligand show that hydrophobic interactions with residues Ile 121 and Phe 66 (Val 115 and Asn 64 in human DHFR) yield selective inhibitors.	Isoleucine	131-134	dihydrofolate reductase	Homo sapiens	52-56
24053334-7	2013	Likewise, comparisons of human and Candida glabrata DHFR bound to the same ligand show that hydrophobic interactions with residues Ile 121 and Phe 66 (Val 115 and Asn 64 in human DHFR) yield selective inhibitors.	Isoleucine	131-134	dihydrofolate reductase	Homo sapiens	179-183
23818523-6	2013	Binding assays using synthetic peptides spanning L4 showed that PEDF selectively bound E5b (Ile(193)-Leu(232)) and P1 (Thr(210)-Leu(249)) peptides.	Isoleucine	92-95	serpin family F member 1	Homo sapiens	64-68
24048853-5	2013	We found that this receptor, OlfCc1 in zebrafish and its murine ortholog Vmn2r1, is a calcium-dependent, low-sensitivity receptor specific for the hydrophobic amino acids isoleucine, leucine, and valine.	Isoleucine	171-181	vomeronasal 2, receptor 1	Danio rerio	29-35
24048853-5	2013	We found that this receptor, OlfCc1 in zebrafish and its murine ortholog Vmn2r1, is a calcium-dependent, low-sensitivity receptor specific for the hydrophobic amino acids isoleucine, leucine, and valine.	Isoleucine	171-181	vomeronasal 2, receptor 1	Mus musculus	73-79
23868449-11	2013	The increase of NADPH concentration and Ile production in a POS5-expressing strain (229 and 75.6 %, respectively) was higher than that in a ppnK-expression strain.	Isoleucine	40-43	NADH kinase	Saccharomyces cerevisiae S288C	60-64
23764339-10	2013	Furthermore, the substitution of isoleucine with valine, but not with methionine nor leucine, at the corresponding position in a rat skeletal muscle sodium channel, rNav1.4, enhanced channel sensitivity to deltamethrin.	Isoleucine	33-43	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	165-172
23761630-0	2013	The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium.	Isoleucine	25-35	ETS transcription factor ERG	Homo sapiens	87-91
23409853-1	2013	A series of Ile-containing elastin-derived peptide-analogs, (Ile-Pro-Gly-Val-Gly)n (n = 7-10) possessing remarkable and reversible coacervation property were newly synthesized.	Isoleucine	12-15	elastin	Homo sapiens	27-34
23834306-10	2013	The hypomethylation of the CpG island provides additional evidence for the variable escape of the HSD17B10 gene from X-chromosome inactivation which could influence the range of severity of HSD10 deficiency, an inherited error in isoleucine metabolism, in heterozygous females.	Isoleucine	230-240	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	98-106
23661707-5	2013	In primary vascular smooth muscle cells, we find that the arrestin pathway-selective AT1 agonist, [Sar(1),Ile(4),Ile(8)]-AngII, but not the neutral AT1 antagonist, losartan, inhibits endogenous B2 receptor signaling.	Isoleucine	106-109	angiotensin II receptor type 1	Homo sapiens	85-88
23661707-5	2013	In primary vascular smooth muscle cells, we find that the arrestin pathway-selective AT1 agonist, [Sar(1),Ile(4),Ile(8)]-AngII, but not the neutral AT1 antagonist, losartan, inhibits endogenous B2 receptor signaling.	Isoleucine	113-116	angiotensin II receptor type 1	Homo sapiens	85-88
23661707-6	2013	In a transfected HEK293 cell model that recapitulates this effect, we find that the actions of [Sar(1),Ile(4), Ile(8)]-AngII require the AT1 receptor and result from arrestin-dependent co-internalization of AT1-B2 heterodimers.	Isoleucine	103-106	angiotensin II receptor type 1	Homo sapiens	137-140
23661707-6	2013	In a transfected HEK293 cell model that recapitulates this effect, we find that the actions of [Sar(1),Ile(4), Ile(8)]-AngII require the AT1 receptor and result from arrestin-dependent co-internalization of AT1-B2 heterodimers.	Isoleucine	103-106	angiotensin II receptor type 1	Homo sapiens	207-210
23661707-6	2013	In a transfected HEK293 cell model that recapitulates this effect, we find that the actions of [Sar(1),Ile(4), Ile(8)]-AngII require the AT1 receptor and result from arrestin-dependent co-internalization of AT1-B2 heterodimers.	Isoleucine	111-114	angiotensin II receptor type 1	Homo sapiens	137-140
23661707-6	2013	In a transfected HEK293 cell model that recapitulates this effect, we find that the actions of [Sar(1),Ile(4), Ile(8)]-AngII require the AT1 receptor and result from arrestin-dependent co-internalization of AT1-B2 heterodimers.	Isoleucine	111-114	angiotensin II receptor type 1	Homo sapiens	207-210
23661707-10	2013	Both radioligand binding assays and quantitative microscopy-based analysis demonstrate that [Sar(1),Ile(4),Ile(8)]-AngII promotes internalization of AT1-B2 heterodimers.	Isoleucine	100-103	angiotensin II receptor type 1	Homo sapiens	149-152
23661707-10	2013	Both radioligand binding assays and quantitative microscopy-based analysis demonstrate that [Sar(1),Ile(4),Ile(8)]-AngII promotes internalization of AT1-B2 heterodimers.	Isoleucine	107-110	angiotensin II receptor type 1	Homo sapiens	149-152
23661707-11	2013	Thus, [Sar(1),Ile(4),Ile(8)]-AngII exerts lateral allosteric modulation of B2 receptor signaling by binding to the orthosteric ligand binding site of the AT1 receptor and promoting co-sequestration of AT1-B2 heterodimers.	Isoleucine	14-17	bradykinin receptor B2	Homo sapiens	75-86
23661707-11	2013	Thus, [Sar(1),Ile(4),Ile(8)]-AngII exerts lateral allosteric modulation of B2 receptor signaling by binding to the orthosteric ligand binding site of the AT1 receptor and promoting co-sequestration of AT1-B2 heterodimers.	Isoleucine	14-17	angiotensin II receptor type 1	Homo sapiens	154-157
23661707-11	2013	Thus, [Sar(1),Ile(4),Ile(8)]-AngII exerts lateral allosteric modulation of B2 receptor signaling by binding to the orthosteric ligand binding site of the AT1 receptor and promoting co-sequestration of AT1-B2 heterodimers.	Isoleucine	14-17	angiotensin II receptor type 1	Homo sapiens	201-204
23661707-11	2013	Thus, [Sar(1),Ile(4),Ile(8)]-AngII exerts lateral allosteric modulation of B2 receptor signaling by binding to the orthosteric ligand binding site of the AT1 receptor and promoting co-sequestration of AT1-B2 heterodimers.	Isoleucine	21-24	bradykinin receptor B2	Homo sapiens	75-86
23661707-11	2013	Thus, [Sar(1),Ile(4),Ile(8)]-AngII exerts lateral allosteric modulation of B2 receptor signaling by binding to the orthosteric ligand binding site of the AT1 receptor and promoting co-sequestration of AT1-B2 heterodimers.	Isoleucine	21-24	angiotensin II receptor type 1	Homo sapiens	154-157
23661707-11	2013	Thus, [Sar(1),Ile(4),Ile(8)]-AngII exerts lateral allosteric modulation of B2 receptor signaling by binding to the orthosteric ligand binding site of the AT1 receptor and promoting co-sequestration of AT1-B2 heterodimers.	Isoleucine	21-24	angiotensin II receptor type 1	Homo sapiens	201-204
23840412-7	2013	(4.33x10(2)) = 7.8x10(4), (ii) the rates of ATP hydrolysis for both Ile and Val at different substrate concentrations in the aminoacylation of tRNA(Ile).	Isoleucine	68-71	mitochondrially encoded tRNA glycine	Homo sapiens	143-152
23530144-7	2013	PTD-PDK1-Thr(513)-Ile blocked binding between PDK1 and PKCtheta, phosphorylation of PKCtheta Thr(538), and activation of both NF-kappaB and AKT.	Isoleucine	18-21	pyruvate dehydrogenase kinase 1	Homo sapiens	4-8
23589288-4	2013	Examination of the active site specificity of C1r using phage library technology revealed clear specificity for Gln at P2 and Ile at P1", which are found in these positions in physiological substrates of C1r.	Isoleucine	126-129	complement C1r	Homo sapiens	46-49
23589288-4	2013	Examination of the active site specificity of C1r using phage library technology revealed clear specificity for Gln at P2 and Ile at P1", which are found in these positions in physiological substrates of C1r.	Isoleucine	126-129	complement C1r	Homo sapiens	204-207
23589288-5	2013	Removal of one or both of the Gln at P2 and Ile at P1" in the C1s substrate reduced the rate of C1r activation.	Isoleucine	44-47	complement C1s	Homo sapiens	62-65
23589288-5	2013	Removal of one or both of the Gln at P2 and Ile at P1" in the C1s substrate reduced the rate of C1r activation.	Isoleucine	44-47	complement C1r	Homo sapiens	96-99
23530144-6	2013	Consequently, cell-permeable peptides with a Thr(513) to Ile derivative (protein transduction domain [PTD]-PDK1-Thr(513)-Ile) bound the kinase domain, whereas a Thr(513)-to-Asp peptide (PTD-PDK1-Thr(513)-Asp) bound the PH domain.	Isoleucine	57-60	pyruvate dehydrogenase kinase 1	Homo sapiens	107-111
23530144-6	2013	Consequently, cell-permeable peptides with a Thr(513) to Ile derivative (protein transduction domain [PTD]-PDK1-Thr(513)-Ile) bound the kinase domain, whereas a Thr(513)-to-Asp peptide (PTD-PDK1-Thr(513)-Asp) bound the PH domain.	Isoleucine	57-60	pyruvate dehydrogenase kinase 1	Homo sapiens	190-194
23530144-7	2013	PTD-PDK1-Thr(513)-Ile blocked binding between PDK1 and PKCtheta, phosphorylation of PKCtheta Thr(538), and activation of both NF-kappaB and AKT.	Isoleucine	18-21	pyruvate dehydrogenase kinase 1	Homo sapiens	46-50
23530144-7	2013	PTD-PDK1-Thr(513)-Ile blocked binding between PDK1 and PKCtheta, phosphorylation of PKCtheta Thr(538), and activation of both NF-kappaB and AKT.	Isoleucine	18-21	protein kinase C theta	Homo sapiens	55-63
23530144-7	2013	PTD-PDK1-Thr(513)-Ile blocked binding between PDK1 and PKCtheta, phosphorylation of PKCtheta Thr(538), and activation of both NF-kappaB and AKT.	Isoleucine	18-21	protein kinase C theta	Homo sapiens	84-92
23530144-7	2013	PTD-PDK1-Thr(513)-Ile blocked binding between PDK1 and PKCtheta, phosphorylation of PKCtheta Thr(538), and activation of both NF-kappaB and AKT.	Isoleucine	18-21	AKT serine/threonine kinase 1	Homo sapiens	140-143
23589815-3	2013	We report a 30-day-old patient with mutations in the SLC19A3 gene who presented with acute encephalopathy and increased level of lactate in the blood (8.6 mmol/L) and cerebrospinal fluid (7.12 mmol/L), a high excretion of alpha-ketoglutarate in the urine, and increased concentrations of the branched-chain amino acids leucine and isoleucine in the plasma.	Isoleucine	331-341	solute carrier family 19 member 3	Homo sapiens	53-60
23764840-1	2013	Here, we report a Chinese case of Creutzfeldt-Jakob disease (CJD) with a rare mutation in the prion protein gene (PRNP) leading to an exchange of amino acid from valine (Val) to isoleucine (I) at codon 203 (V203I).	Isoleucine	178-188	prion protein	Homo sapiens	114-118
23360067-4	2013	When mutated to isoleucine, PI3Kbeta has reduced ability to present a specific cryptic binding site into which a range of reported PI3Kbeta inhibitors can bind, and conversely when tyrosine is introduced into the same position in PI3Kalpha, the same inhibitors gain potency.	Isoleucine	16-26	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	28-36
23360067-4	2013	When mutated to isoleucine, PI3Kbeta has reduced ability to present a specific cryptic binding site into which a range of reported PI3Kbeta inhibitors can bind, and conversely when tyrosine is introduced into the same position in PI3Kalpha, the same inhibitors gain potency.	Isoleucine	16-26	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	Homo sapiens	131-139
23360067-4	2013	When mutated to isoleucine, PI3Kbeta has reduced ability to present a specific cryptic binding site into which a range of reported PI3Kbeta inhibitors can bind, and conversely when tyrosine is introduced into the same position in PI3Kalpha, the same inhibitors gain potency.	Isoleucine	16-26	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	230-239
23560894-3	2013	Because catabolism of branched-chain amino acids (BCAAs; i.e., valine, isoleucine, and leucine) leads to glucose and energy metabolism, and neurotransmitter synthesis and availability, we investigated BCAA metabolites in plasma samples collected within 24 h of injury from mild TBI (Glasgow Coma Scale [GCS] score &gt;12), severe TBI (GCS &lt;=8), orthopedic injury, and healthy volunteers.	Isoleucine	71-81	AT-rich interaction domain 4B	Homo sapiens	50-54
23164225-0	2013	Milk protein responses in dairy cows to changes in postruminal supplies of arginine, isoleucine, and valine.	Isoleucine	85-95	Weaning weight-maternal milk	Bos taurus	0-4
23474214-1	2013	Short/branched chain acyl-CoA dehydrogenase (SBCAD), isovaleryl-CoA dehydrogenase (IVD), and isobutyryl-CoA dehydrogenase (IBD) are involved in metabolism of isoleucine, leucine, and valine, respectively.	Isoleucine	158-168	acyl-CoA dehydrogenase, short/branched chain	Rattus norvegicus	0-43
23474214-1	2013	Short/branched chain acyl-CoA dehydrogenase (SBCAD), isovaleryl-CoA dehydrogenase (IVD), and isobutyryl-CoA dehydrogenase (IBD) are involved in metabolism of isoleucine, leucine, and valine, respectively.	Isoleucine	158-168	acyl-CoA dehydrogenase, short/branched chain	Rattus norvegicus	45-50
23474214-1	2013	Short/branched chain acyl-CoA dehydrogenase (SBCAD), isovaleryl-CoA dehydrogenase (IVD), and isobutyryl-CoA dehydrogenase (IBD) are involved in metabolism of isoleucine, leucine, and valine, respectively.	Isoleucine	158-168	isovaleryl-CoA dehydrogenase	Rattus norvegicus	53-81
23625227-12	2013	We found that MICB*008 which contains methionine and asparagine at the amino acid positions 98 and 113, respectively, in the alpha 2 domain showed decreased binding activities to UL16 when compared to MICB*003, 004, and MICB*00502 containing isoleucine and aspartic acid, respectively.	Isoleucine	242-252	MHC class I polypeptide-related sequence B	Homo sapiens	14-18
23243314-9	2013	A critical selectivity determinant that distinguishes CAL from other CFTR-binding PDZ domains is the accommodation of an isoleucine residue at the C-terminal position (P(0)), a characteristic shared with the Tax-interacting protein-1.	Isoleucine	121-131	golgi associated PDZ and coiled-coil motif containing	Homo sapiens	54-57
23243314-9	2013	A critical selectivity determinant that distinguishes CAL from other CFTR-binding PDZ domains is the accommodation of an isoleucine residue at the C-terminal position (P(0)), a characteristic shared with the Tax-interacting protein-1.	Isoleucine	121-131	CF transmembrane conductance regulator	Homo sapiens	69-73
22978602-7	2013	Using a series of chimeric GlyT1/2 transporters and point mutant transporters, we have identified an isoleucine residue in extracellular loop 4 of GlyT2 that conferred differences in sensitivity to oleoyl-L-carnitine between GlyT2 and GlyT1.	Isoleucine	101-111	solute carrier family 6 member 9	Homo sapiens	27-34
22978602-7	2013	Using a series of chimeric GlyT1/2 transporters and point mutant transporters, we have identified an isoleucine residue in extracellular loop 4 of GlyT2 that conferred differences in sensitivity to oleoyl-L-carnitine between GlyT2 and GlyT1.	Isoleucine	101-111	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	147-152
22978602-7	2013	Using a series of chimeric GlyT1/2 transporters and point mutant transporters, we have identified an isoleucine residue in extracellular loop 4 of GlyT2 that conferred differences in sensitivity to oleoyl-L-carnitine between GlyT2 and GlyT1.	Isoleucine	101-111	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	225-230
22978602-7	2013	Using a series of chimeric GlyT1/2 transporters and point mutant transporters, we have identified an isoleucine residue in extracellular loop 4 of GlyT2 that conferred differences in sensitivity to oleoyl-L-carnitine between GlyT2 and GlyT1.	Isoleucine	101-111	solute carrier family 6 member 9	Homo sapiens	27-32
23307320-2	2013	The use of the matrix 1,5-diaminonapthalene (1,5-DAN) gave abundant w ions, which are formed from the unimolecular dissociation of z  radical fragments via alpha cleavage reaction and thus help identify which of the isobaric amino acids, Leu or Ile, is present.	Isoleucine	245-248	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
23499291-6	2013	Additionally, headless zip/MyoII molecules with and without isoleucine-glutamine or IQ motifs were also expressed in Johnston"s organ neurons.	Isoleucine	60-70	zipper	Drosophila melanogaster	23-32
23065293-5	2013	At 12 h after the treatment by the appropriate concentrations of L-isoleucine or Zn(2+), the mRNA and protein expressions of porcine beta-defensin 1, 2 and 3 were increased (P &lt; 0.05), and reached their maximum after treatment with 25 or 100 mumol/mL zinc sulfate and 25 or 50 mug/mL isoleucine (P &lt; 0.05).	Isoleucine	65-77	beta-defensin 1	Sus scrofa	133-157
23065293-5	2013	At 12 h after the treatment by the appropriate concentrations of L-isoleucine or Zn(2+), the mRNA and protein expressions of porcine beta-defensin 1, 2 and 3 were increased (P &lt; 0.05), and reached their maximum after treatment with 25 or 100 mumol/mL zinc sulfate and 25 or 50 mug/mL isoleucine (P &lt; 0.05).	Isoleucine	67-77	beta-defensin 1	Sus scrofa	133-157
23104431-4	2013	Ten alanine mutants of human P-gp drug-binding amino acids-Leu(65), Ile(306), Phe(336), Ile(340), Phe(343), Phe(728), Phe(942), Thr(945), Leu(975), and Val(982)-were generated and expressed in HEK293 cells with a mammalian baculovirus system.	Isoleucine	68-71	ATP binding cassette subfamily B member 1	Homo sapiens	29-33
23104431-4	2013	Ten alanine mutants of human P-gp drug-binding amino acids-Leu(65), Ile(306), Phe(336), Ile(340), Phe(343), Phe(728), Phe(942), Thr(945), Leu(975), and Val(982)-were generated and expressed in HEK293 cells with a mammalian baculovirus system.	Isoleucine	88-91	ATP binding cassette subfamily B member 1	Homo sapiens	29-33
23408397-0	2013	Supplemental leucine and isoleucine affect  expression of cationic amino acid transporters and  myosin, serum concentration of amino acids, and growth performance of pigs.	Isoleucine	25-35	myosin X	Sus scrofa	96-102
23408397-8	2013	Leu and Ile, alone or in combination, significantly decreased  expression of b(0,+) and significantly increased CAT-1.	Isoleucine	8-11	solute carrier family 7 member 1	Sus scrofa	112-117
23408397-9	2013	Ile  alone or combined with Leu significantly decreased myosin expression in  semitendinosus and significantly decreased it in longissimus muscle.	Isoleucine	0-3	myosin X	Sus scrofa	56-62
23139413-11	2013	However, a lid conformation was induced by [Sar(1),Gln(2),Ile(8)] AngII, a specific analog that binds to the D281A mutant with better affinity than AngII.	Isoleucine	58-61	angiotensinogen	Homo sapiens	66-71
23139413-11	2013	However, a lid conformation was induced by [Sar(1),Gln(2),Ile(8)] AngII, a specific analog that binds to the D281A mutant with better affinity than AngII.	Isoleucine	58-61	angiotensinogen	Homo sapiens	148-153
23161549-7	2013	Binding of t-PA to VDAC occurs between a t-PA fibronectin type I finger domain located between amino acids Ile(5) and Asn(37) and a VDAC region including amino acids (20)GYGFG(24).	Isoleucine	107-110	plasminogen activator, tissue type	Homo sapiens	11-15
23161549-7	2013	Binding of t-PA to VDAC occurs between a t-PA fibronectin type I finger domain located between amino acids Ile(5) and Asn(37) and a VDAC region including amino acids (20)GYGFG(24).	Isoleucine	107-110	plasminogen activator, tissue type	Homo sapiens	41-45
23164225-13	2013	The slight effect on the milk protein-to-fat ratio caused by decreasing the supply of Ile suggests a need to reevaluate the Ile requirement more precisely.	Isoleucine	86-89	Weaning weight-maternal milk	Bos taurus	25-29
23164225-13	2013	The slight effect on the milk protein-to-fat ratio caused by decreasing the supply of Ile suggests a need to reevaluate the Ile requirement more precisely.	Isoleucine	124-127	Weaning weight-maternal milk	Bos taurus	25-29
23097434-1	2013	We have recently isolated a rhesus macaque cytotoxic T cell line, 2N5.1, that specifically recognizes an N-myristoylated 5-mer peptide (C(14)-Gly-Gly-Ala-Ile-Ser [C14nef5]) derived from the simian immunodeficiency virus (SIV) Nef protein.	Isoleucine	154-157	nef protein	Simian immunodeficiency virus	226-229
23023372-8	2012	No genome-wide significance was observed, but taking a hypothesis-driven approach, there was a suggestive association between the T allele at rs37369 (which causes a valine-isoleucine substitution and altered levels of AGXT2 substrate) and a modest increase in diastolic blood pressure (P=0.0052).	Isoleucine	173-183	alanine-glyoxylate aminotransferase 2	Mus musculus	219-224
23505486-12	2013	Ferrous iron in the active site of 5-LOX is coordinated by three conserved histidines and the carboxylate of isoleucine(673).	Isoleucine	109-119	arachidonate 5-lipoxygenase	Homo sapiens	35-40
22999566-2	2012	A novel heterozygous guanine (G)-to-thymine (T) transition at position 1392, c.1392G>T, leading to a methionine-to-isoleucine substitution (p.Met464Ile), was found in exon13 of FUS.	Isoleucine	115-125	FUS RNA binding protein	Homo sapiens	177-180
23035122-6	2012	In addition to the PX domain, a region in the pleckstrin homology domain (Ile-306-Ala-310) aids in the PX-mediated GEF activity by providing a docking site to hold Rac2 in place during catalysis.	Isoleucine	74-77	Ras protein specific guanine nucleotide releasing factor 1	Homo sapiens	115-118
23178880-2	2012	Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1.	Isoleucine	68-71	epidermal growth factor receptor	Homo sapiens	25-29
23178880-2	2012	Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1.	Isoleucine	68-71	mitogen-activated protein kinase 1	Homo sapiens	40-44
23178880-2	2012	Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1.	Isoleucine	68-71	pyruvate kinase M1/2	Homo sapiens	63-67
23178880-2	2012	Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1.	Isoleucine	68-71	mitogen-activated protein kinase 1	Homo sapiens	96-100
23178880-2	2012	Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1.	Isoleucine	68-71	pyruvate kinase M1/2	Homo sapiens	135-139
23035122-6	2012	In addition to the PX domain, a region in the pleckstrin homology domain (Ile-306-Ala-310) aids in the PX-mediated GEF activity by providing a docking site to hold Rac2 in place during catalysis.	Isoleucine	74-77	Rac family small GTPase 2	Homo sapiens	164-168
23055527-1	2012	BACKGROUND: TLR4 polymorphism replacing Asp-299 with Gly and Thr-399 with Ile (D299G/T399I) causes LPS hyporesponsiveness.	Isoleucine	74-77	toll like receptor 4	Homo sapiens	12-16
22791552-15	2012	Using exome sequencing in MS probands, we identified de novo SMAD4 missense mutations, all involving isoleucine residue at position 500, in the MH2 domain.	Isoleucine	101-111	SMAD family member 4	Homo sapiens	61-66
22989873-9	2012	In CaBP7 NTD, these residues are replaced with isoleucine and leucine residues with branched side chains that are intrinsically more rigid than the flexible methionine side chain.	Isoleucine	47-57	calcium binding protein 7	Homo sapiens	3-8
22955279-6	2012	Ile-184 in p66 (p66(184I)) decreased the catalytic efficiency of RT (k(pol)/K(d)(.dNTP)), primarily through a decrease in dNTP binding (K(d)(.dNTP)).	Isoleucine	0-3	DNA polymerase delta 3, accessory subunit	Homo sapiens	11-14
22955279-6	2012	Ile-184 in p66 (p66(184I)) decreased the catalytic efficiency of RT (k(pol)/K(d)(.dNTP)), primarily through a decrease in dNTP binding (K(d)(.dNTP)).	Isoleucine	0-3	DNA polymerase delta 3, accessory subunit	Homo sapiens	16-19
22955279-10	2012	p66(184I) caused repositioning of the Tyr-183 active site residue and decreased the efficiency of RT, whereas the addition of p51(138K) restored Tyr-183 to a WT-like conformation, thus abrogating the Ile-184-induced functional defects.	Isoleucine	200-203	DNA polymerase delta 3, accessory subunit	Homo sapiens	0-3
22955279-10	2012	p66(184I) caused repositioning of the Tyr-183 active site residue and decreased the efficiency of RT, whereas the addition of p51(138K) restored Tyr-183 to a WT-like conformation, thus abrogating the Ile-184-induced functional defects.	Isoleucine	200-203	tumor protein p63	Homo sapiens	126-129
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Isoleucine	166-169	membrane metalloendopeptidase	Homo sapiens	9-19
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Isoleucine	166-169	islet amyloid polypeptide	Homo sapiens	30-34
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Isoleucine	166-169	islet amyloid polypeptide	Homo sapiens	62-66
22918858-6	2012	Contrary, cathepsin G was activated by IPP, VPP and LPP as well as the amino acids proline and isoleucine.	Isoleucine	95-105	cathepsin G	Homo sapiens	10-21
22002349-3	2012	We have achieved complete backbone and stereospecific methyl sidechain Ile (delta1), Leu and Val chemical shifts of first 243 amino acids of RDE-4, namely RDE-4DeltaC.	Isoleucine	71-74	Uncharacterized protein	Caenorhabditis elegans	141-146
23048130-8	2012	As the transgenic rice plants overexpressing EcSAT had significantly higher levels of both soluble and protein-bound methionine, isoleucine, cysteine, and glutathione in rice they may represent a model and target system for improving the nutritional quality of cereal crops.	Isoleucine	129-139	streptothricin acetyltransferase	Escherichia coli	45-50
22785121-6	2012	Both I188C and M193C mutants were functional and were inhibited by membrane-impermeable sulfhydryl-reactive reagents; this could be prevented with PCFT substrate, but the protection was sustained at 0 C only for the I188C mutant, consistent with localization of Ile-188 in the PCFT folate binding pocket.	Isoleucine	262-265	solute carrier family 46 member 1	Homo sapiens	147-151
22785121-6	2012	Both I188C and M193C mutants were functional and were inhibited by membrane-impermeable sulfhydryl-reactive reagents; this could be prevented with PCFT substrate, but the protection was sustained at 0 C only for the I188C mutant, consistent with localization of Ile-188 in the PCFT folate binding pocket.	Isoleucine	262-265	solute carrier family 46 member 1	Homo sapiens	277-281
23107693-6	2012	Leu-Pro and Ile-Pro were identified as the inhibitory peptides among the RB peptides produced with Umamizyme G. Ile-Pro was the strongest DPP-IV inhibitor among the 15 Xaa-Pro dipeptides and Pro-Ile tested.	Isoleucine	12-15	dipeptidyl peptidase 4	Homo sapiens	138-144
22943296-5	2012	Further, the residues Lys 18, Thr 20, Ala 21, Val 22, Phe 46, Glu 48, Lys 50, Lys 58, Thr 75, Gln 77, Arg 97 and Ile 98 form hot point motif, which on interaction enhances BDNF"s function.	Isoleucine	113-116	brain derived neurotrophic factor	Homo sapiens	172-176
22189890-1	2012	Changes in plasma aromatic amino acids (AAA = phenylalanine, tryptophan, tyrosine) and branched chain amino acids (BCAA = isoleucine, leucine, valine) levels possibly influencing intracranial pressure (ICP) and cerebral oxygen consumption (SjvO(2)) were investigated in 19 sedated patients up to 14 days following severe traumatic brain injury (TBI).	Isoleucine	122-132	AT-rich interaction domain 4B	Homo sapiens	115-119
22947880-3	2012	Here, we show that the kinetics and voltage dependence of VSD movement in Ci-VSP can be tuned over 2 orders of magnitude and shifted over 120 mV, respectively, by the size of a conserved isoleucine (I126) in the S1 segment, thus indicating the importance of this residue in Ci-VSP activation.	Isoleucine	187-197	voltage-sensor containing phosphatase	Ciona intestinalis	77-80
22947880-3	2012	Here, we show that the kinetics and voltage dependence of VSD movement in Ci-VSP can be tuned over 2 orders of magnitude and shifted over 120 mV, respectively, by the size of a conserved isoleucine (I126) in the S1 segment, thus indicating the importance of this residue in Ci-VSP activation.	Isoleucine	187-197	voltage-sensor containing phosphatase	Ciona intestinalis	277-280
22776297-5	2012	CD analysis suggested that the Ile residues are necessary for the formation of a specific conformation required for binding to syndecan-4.	Isoleucine	31-34	syndecan 4	Homo sapiens	127-137
22707719-5	2012	Replacing the thrombospondin-1/cysteine-rich/spacer domains of ADAMTS5 with those of ADAMTS13 conferred the ability to cleave the Glu(1615)-Ile(1616) bond of VWF domain A2 in peptide substrates or VWF multimers that had been sheared; native (unsheared) VWF multimers were resistant.	Isoleucine	140-143	thrombospondin 1	Bos taurus	14-30
22707719-5	2012	Replacing the thrombospondin-1/cysteine-rich/spacer domains of ADAMTS5 with those of ADAMTS13 conferred the ability to cleave the Glu(1615)-Ile(1616) bond of VWF domain A2 in peptide substrates or VWF multimers that had been sheared; native (unsheared) VWF multimers were resistant.	Isoleucine	140-143	ADAM metallopeptidase with thrombospondin type 1 motif 5	Bos taurus	63-70
22707719-5	2012	Replacing the thrombospondin-1/cysteine-rich/spacer domains of ADAMTS5 with those of ADAMTS13 conferred the ability to cleave the Glu(1615)-Ile(1616) bond of VWF domain A2 in peptide substrates or VWF multimers that had been sheared; native (unsheared) VWF multimers were resistant.	Isoleucine	140-143	ADAM metallopeptidase with thrombospondin type 1 motif 13	Bos taurus	85-93
22707719-5	2012	Replacing the thrombospondin-1/cysteine-rich/spacer domains of ADAMTS5 with those of ADAMTS13 conferred the ability to cleave the Glu(1615)-Ile(1616) bond of VWF domain A2 in peptide substrates or VWF multimers that had been sheared; native (unsheared) VWF multimers were resistant.	Isoleucine	140-143	von Willebrand factor	Bos taurus	158-161
22707719-5	2012	Replacing the thrombospondin-1/cysteine-rich/spacer domains of ADAMTS5 with those of ADAMTS13 conferred the ability to cleave the Glu(1615)-Ile(1616) bond of VWF domain A2 in peptide substrates or VWF multimers that had been sheared; native (unsheared) VWF multimers were resistant.	Isoleucine	140-143	von Willebrand factor	Bos taurus	197-200
22707719-5	2012	Replacing the thrombospondin-1/cysteine-rich/spacer domains of ADAMTS5 with those of ADAMTS13 conferred the ability to cleave the Glu(1615)-Ile(1616) bond of VWF domain A2 in peptide substrates or VWF multimers that had been sheared; native (unsheared) VWF multimers were resistant.	Isoleucine	140-143	von Willebrand factor	Bos taurus	197-200
22707720-6	2012	Alanine replacement of Leu(180)-Ile(181) led to partial constitutive activation of TbetaRI, resulting in part from its retention at the plasma membrane and in part from potential alterations of TbetaRI regulatory interactions in the vicinity of the mutated residues.	Isoleucine	32-35	transforming growth factor beta receptor 1	Homo sapiens	83-90
22707720-6	2012	Alanine replacement of Leu(180)-Ile(181) led to partial constitutive activation of TbetaRI, resulting in part from its retention at the plasma membrane and in part from potential alterations of TbetaRI regulatory interactions in the vicinity of the mutated residues.	Isoleucine	32-35	transforming growth factor beta receptor 1	Homo sapiens	194-201
22654118-11	2012	Further, alanine substitution analysis of both the A2-8 peptide and the rec-a2LN+ protein revealed that the amino acids Ile-122, Leu-124, and Asp-125 were involved in integrin alpha2beta1-mediated cell attachment, suggesting that the A2-8 site plays a functional role as an integrin alpha2beta1 binding site in the LN module.	Isoleucine	120-123	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	51-55
22628607-7	2012	RESULTS: Sequencing of the KCNJ5 gene revealed a single, heterozygous guanine to thymine (G   T) substitution at nucleotide position 470 (n.G470T), resulting in isoleucine (I) to serine (S) substitution at amino acid 157 (p.I157S).	Isoleucine	161-171	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	27-32
22654118-11	2012	Further, alanine substitution analysis of both the A2-8 peptide and the rec-a2LN+ protein revealed that the amino acids Ile-122, Leu-124, and Asp-125 were involved in integrin alpha2beta1-mediated cell attachment, suggesting that the A2-8 site plays a functional role as an integrin alpha2beta1 binding site in the LN module.	Isoleucine	120-123	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	234-238
22314840-4	2012	Multiple rational design cycles were utilized to develop a lead peptide with a phenylalanine and alanine replaced by an (N-methyl)phenylalanine and isoleucine, respectively, to attain cytosolic peptidase resistance while maintaining Abl substrate efficacy.	Isoleucine	148-158	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	233-236
22792071-4	2012	We identified a missense SNP (Thr&gt;Ile; rs2707466) located in the WNT16 gene (7q31), associated with CBT (effect size of -0.11 standard deviations [SD] per C allele, P = 6.2 x 10(-9)).	Isoleucine	37-40	wingless-type MMTV integration site family, member 16	Mus musculus	68-73
22577081-7	2012	The I187T mutation is localized at the highly conserved isoleucine at a transmembrane domain of the ND1 polypeptide.	Isoleucine	56-66	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	100-103
22553379-6	2012	Only 1 of 43 risk single nucleotide polymorphisms for type 2 diabetes or hyperglycemia, the glucose-increasing major C allele of rs780094 of GCKR, was significantly associated with decreased levels of alanine and isoleucine and elevated levels of glutamine.	Isoleucine	213-223	glucokinase regulator	Homo sapiens	141-145
22496446-2	2012	In this study calpain was found to cleave GSK-3beta not only at the N terminus but also at the C terminus, and cleavage sites were identified at residues Thr-38-Thr-39 and Ile-384-Gln-385.	Isoleucine	172-175	glycogen synthase kinase 3 beta	Homo sapiens	42-51
22461631-5	2012	Substitution of the Notch Cys-1752 residue, which interacts with the S2 subsite, with Val, Met, or Ile has little effect on wild-type PS1 but leads to more efficient substrates for mutant PS1s.	Isoleucine	99-102	notch receptor 1	Homo sapiens	20-25
22492876-9	2012	A trinucleotide deletion in SLC2A1, coding for the deletion of isoleucine 435 or 436 in GLUT1, was identified in the proband.	Isoleucine	63-73	solute carrier family 2 member 1	Homo sapiens	28-34
22492876-9	2012	A trinucleotide deletion in SLC2A1, coding for the deletion of isoleucine 435 or 436 in GLUT1, was identified in the proband.	Isoleucine	63-73	solute carrier family 2 member 1	Homo sapiens	88-93
22458599-6	2012	Conversion of a single isoleucine (Ile36) within this motif to phenylalanine, the residue present in PEP-19, imparts calmodulin binding onto Pcp4l1.	Isoleucine	23-33	Purkinje cell protein 4	Homo sapiens	101-107
22458599-6	2012	Conversion of a single isoleucine (Ile36) within this motif to phenylalanine, the residue present in PEP-19, imparts calmodulin binding onto Pcp4l1.	Isoleucine	23-33	calmodulin 1	Homo sapiens	117-127
22458599-6	2012	Conversion of a single isoleucine (Ile36) within this motif to phenylalanine, the residue present in PEP-19, imparts calmodulin binding onto Pcp4l1.	Isoleucine	23-33	Purkinje cell protein 4 like 1	Homo sapiens	141-147
22445753-7	2012	More detailed analyses showed that substituting the Thr(130)-Val(131) sequence in the RAMP3 TMD with the corresponding sequence (Ile(157)-Pro(158)) from RAMP2 significantly enhanced AM-mediated CLR internalization.	Isoleucine	129-132	receptor activity modifying protein 3	Homo sapiens	86-91
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P &lt; 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Isoleucine	24-36	mechanistic target of rapamycin kinase	Homo sapiens	82-111
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P &lt; 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Isoleucine	24-36	mechanistic target of rapamycin kinase	Homo sapiens	113-117
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P &lt; 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Isoleucine	24-36	ribosomal protein S6	Homo sapiens	132-152
22298573-7	2012	Supplementation of L-isoleucine increased mTOR, S6K1, and rpS6 phosphorylation (P &lt; 0.05).	Isoleucine	19-31	mechanistic target of rapamycin kinase	Bos taurus	42-46
22298573-7	2012	Supplementation of L-isoleucine increased mTOR, S6K1, and rpS6 phosphorylation (P &lt; 0.05).	Isoleucine	19-31	ribosomal protein S6 kinase B1	Bos taurus	48-52
22298573-7	2012	Supplementation of L-isoleucine increased mTOR, S6K1, and rpS6 phosphorylation (P &lt; 0.05).	Isoleucine	19-31	40S ribosomal protein S6	Bos taurus	58-62
22445753-7	2012	More detailed analyses showed that substituting the Thr(130)-Val(131) sequence in the RAMP3 TMD with the corresponding sequence (Ile(157)-Pro(158)) from RAMP2 significantly enhanced AM-mediated CLR internalization.	Isoleucine	129-132	receptor activity modifying protein 2	Homo sapiens	153-158
22445753-7	2012	More detailed analyses showed that substituting the Thr(130)-Val(131) sequence in the RAMP3 TMD with the corresponding sequence (Ile(157)-Pro(158)) from RAMP2 significantly enhanced AM-mediated CLR internalization.	Isoleucine	129-132	calcitonin receptor like receptor	Homo sapiens	194-197
21854182-4	2012	When the inhibitory effect of BCAAs on tyrosinase was examined by intracellular tyrosinase assay, both isoleucine and valine exhibit slightly inhibition, but leucine and combination of BCAAs did not inhibit the cell-derived tyrosinase activity.	Isoleucine	103-113	tyrosinase	Mus musculus	39-49
22328677-17	2012	The ilvE strain exhibits a defect in F(1)-F(o) ATPase activity and has reduced catabolic activity for isoleucine and valine.	Isoleucine	102-112	branched-chain amino acid aminotransferase	Streptococcus mutans UA159	4-8
23961177-10	2012	However, Met, Ile, Phe and His were significantly higher for beta-casein of Majaheim compared to the other two milk breeds.	Isoleucine	14-17	beta-casein	Camelus bactrianus	61-72
22390654-1	2012	The conformational landscape of isoleucine was investigated by a theoretical DFT and MP2 study.	Isoleucine	32-42	tryptase pseudogene 1	Homo sapiens	85-88
22270360-5	2012	Like the previously studied W26A mutation, N-methylation of Ile-20 dramatically reduced the ability of HNP1 to kill Staphylococcus aureus, inhibit LF, and bind gp120.	Isoleucine	60-63	HNP1	Homo sapiens	103-107
22270360-5	2012	Like the previously studied W26A mutation, N-methylation of Ile-20 dramatically reduced the ability of HNP1 to kill Staphylococcus aureus, inhibit LF, and bind gp120.	Isoleucine	60-63	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	160-165
22270360-9	2012	Surface plasmon resonance studies revealed that Trp-26 mediated the association of monomers and canonical dimers of HNP1 to immobilized HNP1, LF, and gp120, and also indicated a possible mode of tetramerization of HNP1 mediated by Ile-20 and Leu-25.	Isoleucine	231-234	HNP1	Homo sapiens	116-120
22315216-10	2012	Non-conserved residues in the binding pocket that strongly contribute to D1/D2 receptor agonist selectivity were also identified; those were Ser/Cys3 36, Tyr/Phe5 38, Ser/Tyr5 41, and Asn/His6 55 in the transmembrane (TM) helix region, together with Ser/Ile and Leu/Asn in the second extracellular loop (EC2).	Isoleucine	254-257	leiomodin 1	Homo sapiens	73-78
22105074-4	2012	Here, using chimeric and point-mutated GLP1R/GIPR, we determined that evolutionarily conserved amino acid residues such as Ile(196) at transmembrane helix 2, Leu(232) and Met(233) at extracellular loop 1, and Asn(302) at extracellular loop 2 of GLP1R are responsible for interaction with ligand and receptor activation.	Isoleucine	123-126	glucagon like peptide 1 receptor	Homo sapiens	39-44
22105074-4	2012	Here, using chimeric and point-mutated GLP1R/GIPR, we determined that evolutionarily conserved amino acid residues such as Ile(196) at transmembrane helix 2, Leu(232) and Met(233) at extracellular loop 1, and Asn(302) at extracellular loop 2 of GLP1R are responsible for interaction with ligand and receptor activation.	Isoleucine	123-126	gastric inhibitory polypeptide receptor	Homo sapiens	45-49
22221029-4	2012	A SNP in exon eight of ME1 resulted in a non-synonymous amino acid change from valine to isoleucine.	Isoleucine	89-99	malic enzyme 1	Bos taurus	23-26
22296999-4	2012	In man, a negative correlation between the insulin response and the concentrations of isoleucine, valine and methionine have been shown but results from horses are lacking.	Isoleucine	86-96	insulin	Homo sapiens	43-50
21956730-4	2012	By generating recombinant refolded iNKT-cell TCRs, we show that natural single-nucleotide variations in iNKTalpha, translating to serine, threonine, asparagine or isoleucine at p93, exert a powerful effect on CD1d binding, with up to 28-fold differences in affinity between these variants.	Isoleucine	163-173	CD1d molecule	Homo sapiens	209-213
22210247-9	2012	The nucleotide sequence of the patient"s CYP11B1 revealed two novel mutations in exon 4: a missense mutation that converts codon AGT (serine) to ATT (isoleucine) (c.650G&gt;T; p.S217I) combined with an insertion of a thymine at the c.652-653 position (c.652_653insT).	Isoleucine	150-160	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	41-48
22957257-10	2012	The mutation affects a conserved valine replacing it with a larger isoleucine residue in the region of contact between the light chain and the myosin lever arm.	Isoleucine	67-77	myosin heavy chain 14	Homo sapiens	143-149
21711092-2	2012	The substitution of isoleucine to valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity and hence less capability of effective detoxification.	Isoleucine	20-30	glutathione S-transferase pi 1	Homo sapiens	72-77
23090274-2	2012	This study evaluated transport activity of full length hVMAT1 isoform-a (NP_003044.1) with a threonine (Thr) or isoleucine (Ile) at amino acid 136 and hVMAT1 isoform-b (NP_00135796.1) with a 136-Thr and deletion of 32 amino acids in the central region of the protein.	Isoleucine	112-122	solute carrier family 18 member A1	Homo sapiens	55-61
23090274-2	2012	This study evaluated transport activity of full length hVMAT1 isoform-a (NP_003044.1) with a threonine (Thr) or isoleucine (Ile) at amino acid 136 and hVMAT1 isoform-b (NP_00135796.1) with a 136-Thr and deletion of 32 amino acids in the central region of the protein.	Isoleucine	124-127	solute carrier family 18 member A1	Homo sapiens	55-61
21247997-1	2011	Beta-ketothiolase deficiency is a rare autosomal recessive disorder of isoleucine and ketone body metabolism.	Isoleucine	71-81	acetyl-CoA acyltransferase 1	Homo sapiens	0-17
23056546-9	2012	The overall data indicated a significant association of CYP1A1 Ile462Val polymorphism with acute leukemia risk (Val/Val vs Ile/Ile OR = 1.49; 95% CI = 1.11-1.98; dominant model: OR = 1.26; 95% CI = 1.05-1.51; recessive model: OR = 1.38; 95% CI = 1.04-1.83).	Isoleucine	63-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
22984419-9	2012	Finally, direct mutagenesis of an isoleucine (Ile131) in the hydrophobic patch of the GTPCH1 UBD affected its ubiquitin binding and the enzyme stability.	Isoleucine	34-44	GTP cyclohydrolase 1	Homo sapiens	86-92
22848402-6	2012	Using a proteomic analysis, we determined that the cleavage occurs in a conserved motif of the N-terminal nucleotide binding site, between Ile-126 and Gly-127 in Hsp90beta, and between Ile-131 and Gly-132 in Hsp90alpha.	Isoleucine	139-142	heat shock protein 90 alpha family class B member 1	Homo sapiens	162-171
22848402-6	2012	Using a proteomic analysis, we determined that the cleavage occurs in a conserved motif of the N-terminal nucleotide binding site, between Ile-126 and Gly-127 in Hsp90beta, and between Ile-131 and Gly-132 in Hsp90alpha.	Isoleucine	139-142	heat shock protein 90 alpha family class A member 1	Homo sapiens	208-218
22848402-6	2012	Using a proteomic analysis, we determined that the cleavage occurs in a conserved motif of the N-terminal nucleotide binding site, between Ile-126 and Gly-127 in Hsp90beta, and between Ile-131 and Gly-132 in Hsp90alpha.	Isoleucine	185-188	heat shock protein 90 alpha family class A member 1	Homo sapiens	208-218
22395499-11	2012	The presence of Ile/Val polymorphism of CYP1A1 gene was identified in 9.5% of the cases and the MspI polymorphism of CYP1A1 gene was not identified in our subjects.	Isoleucine	16-19	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-46
22646841-13	2012	CONCLUSION: The results of this study suggest that there is a positive correlation between some serum amino acid values, especially serine, glycine, isoleucine, and phenylalanine, and the high concentrations of SAA in chickens with amyloid arthropathy.	Isoleucine	149-159	serum amyloid A	Gallus gallus	211-214
21997313-2	2011	The aim of this study was to evaluate the effects of the HER2 I655V polymorphism (ATC/isoleucine to GTC/valine) on lipid profiles after tamoxifen treatment.	Isoleucine	86-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-61
21832286-5	2011	Interestingly, alanine mutations of Leu(175(4.61)), Ile(177(4.63)), and Met(180(4.66)) decreased mutant receptor affinity for GnRH I but, in contrast, increased affinity for GnRH II.	Isoleucine	52-55	gonadotropin releasing hormone 2	Homo sapiens	174-181
22215670-2	2012	Jasmonoyl-isoleucine (JA-Ile) has been identified as a specific ligand binding the COI1-JAZ co-receptor to relieve repression of jasmonate responses.	Isoleucine	25-28	RNI-like superfamily protein	Arabidopsis thaliana	83-87
23300778-3	2012	Emb-LPD induced changes in maternal serum metabolites at the time of blastocyst formation (E3.5), notably reduced insulin and increased glucose, together with reduced levels of free amino acids (AAs) including branched chain AAs leucine, isoleucine and valine.	Isoleucine	238-248	embigin	Mus musculus	0-3
23300778-3	2012	Emb-LPD induced changes in maternal serum metabolites at the time of blastocyst formation (E3.5), notably reduced insulin and increased glucose, together with reduced levels of free amino acids (AAs) including branched chain AAs leucine, isoleucine and valine.	Isoleucine	238-248	acyl-CoA synthetase bubblegum family member 1	Mus musculus	4-7
22673745-3	2012	We hypothesize that variation of amino acid residue 43 between RhoA/B (valine) and RhoC (isoleucine) impacts GEF activity.	Isoleucine	89-99	ras homolog family member A	Homo sapiens	63-69
22673745-3	2012	We hypothesize that variation of amino acid residue 43 between RhoA/B (valine) and RhoC (isoleucine) impacts GEF activity.	Isoleucine	89-99	ras homolog family member C	Homo sapiens	83-87
22673745-3	2012	We hypothesize that variation of amino acid residue 43 between RhoA/B (valine) and RhoC (isoleucine) impacts GEF activity.	Isoleucine	89-99	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	109-112
21930699-9	2011	EhRho1 exhibits a fast rate of nucleotide exchange relative to mammalian Rho GTPases due to a distinctive switch one isoleucine residue reminiscent of the constitutively active F28L mutation in human Cdc42, which for the latter protein, is sufficient for cellular transformation.	Isoleucine	117-127	cell division cycle 42	Homo sapiens	200-205
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Isoleucine	23-33	protein inhibitor of activated STAT 3	Homo sapiens	87-92
22008938-2	2011	The common metabolic engineering approach uses the last two steps of the Ehrlich pathway, catalyzed by 2-ketoacid decarboxylase and an alcohol dehydrogenase converting the branched chain 2-ketoacids of L-isoleucine, L-leucine, and L-valine into the respective alcohols.	Isoleucine	202-214	Alcohol dehydrogenase	Escherichia coli	135-156
21851958-3	2011	By constructing chimeric Envs and fine mapping between sensitive and resistant Env clones, we found that substitution of highly conserved isoleucine (I) with methionine (M) (ATA to ATG) at position 424 in the C4 domain conferred enhanced neutralization sensitivity of Env-pseudotyped viruses to autologous and heterologous plasma antibodies.	Isoleucine	138-148	endogenous retrovirus group K member 20	Homo sapiens	25-28
21851958-3	2011	By constructing chimeric Envs and fine mapping between sensitive and resistant Env clones, we found that substitution of highly conserved isoleucine (I) with methionine (M) (ATA to ATG) at position 424 in the C4 domain conferred enhanced neutralization sensitivity of Env-pseudotyped viruses to autologous and heterologous plasma antibodies.	Isoleucine	138-148	endogenous retrovirus group K member 20	Homo sapiens	79-82
21457730-3	2011	The shortest molecule which elicited anxiolytic effects was the tripeptide Ucn 3 (36-38), H-Ala-Gln-Ile-NH(2).	Isoleucine	100-103	urocortin 3	Mus musculus	75-80
21757689-5	2011	GroES Ile-25, Val-26, and Leu-27, residues on the GroEL-GroES interface, were substituted with Asp on different groES modules of groES(7).	Isoleucine	6-9	heat shock protein family E (Hsp10) member 1	Homo sapiens	0-5
21757689-5	2011	GroES Ile-25, Val-26, and Leu-27, residues on the GroEL-GroES interface, were substituted with Asp on different groES modules of groES(7).	Isoleucine	6-9	heat shock protein family D (Hsp60) member 1	Homo sapiens	50-55
21757689-5	2011	GroES Ile-25, Val-26, and Leu-27, residues on the GroEL-GroES interface, were substituted with Asp on different groES modules of groES(7).	Isoleucine	6-9	heat shock protein family E (Hsp10) member 1	Homo sapiens	129-134
21628446-4	2011	Chromatographic purification and structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an Ang II-like octapeptide, angioprotectin, with the sequence Pro-Glu-Val-Tyr-Ile-His-Pro-Phe, which differs from Ang II in Pro1 and Glu2 instead of Asp1 and Arg2.	Isoleucine	233-236	angiogenin	Homo sapiens	158-161
21628446-4	2011	Chromatographic purification and structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an Ang II-like octapeptide, angioprotectin, with the sequence Pro-Glu-Val-Tyr-Ile-His-Pro-Phe, which differs from Ang II in Pro1 and Glu2 instead of Asp1 and Arg2.	Isoleucine	233-236	angiotensinogen	Homo sapiens	158-164
21628446-5	2011	Pro-Glu-Val-Tyr-Ile-His-Pro-Phe in angioprotectin is most likely generated enzymatically from Ang II.	Isoleucine	16-19	angiotensinogen	Homo sapiens	94-100
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Isoleucine	23-33	signal transducer and activator of transcription 3	Homo sapiens	115-120
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Isoleucine	23-33	protein inhibitor of activated STAT 3	Homo sapiens	121-126
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Isoleucine	47-57	protein inhibitor of activated STAT 3	Homo sapiens	87-92
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Isoleucine	47-57	signal transducer and activator of transcription 3	Homo sapiens	115-120
21812053-2	2011	The conserved proline, isoleucine, asparagine, isoleucine, threonine (PINIT) domain of PIAS3 is thought to promote STAT3-PIAS3 interaction.	Isoleucine	47-57	protein inhibitor of activated STAT 3	Homo sapiens	121-126
21757345-2	2011	Substitution of Val by other amino acid residues revealed several highly potent furin inhibitors with K(i) values of less than 2nM, containing guanidinoalanine, Ile, Phe or Tyr in the P3 position.	Isoleucine	161-164	furin, paired basic amino acid cleaving enzyme	Homo sapiens	80-85
21963667-3	2011	The endogenous bioactive JA-Ile conjugate mediates the binding of JAZ proteins to the F-box protein CORONATINE INSENSITIVE1 (COI1), part of the Skp1/Cullin/F-box SCF(COI1) ubiquitin E3 ligase complex.	Isoleucine	28-31	RNI-like superfamily protein	Arabidopsis thaliana	125-129
21963667-3	2011	The endogenous bioactive JA-Ile conjugate mediates the binding of JAZ proteins to the F-box protein CORONATINE INSENSITIVE1 (COI1), part of the Skp1/Cullin/F-box SCF(COI1) ubiquitin E3 ligase complex.	Isoleucine	28-31	S phase kinase-associated protein 1	Arabidopsis thaliana	144-148
21963667-3	2011	The endogenous bioactive JA-Ile conjugate mediates the binding of JAZ proteins to the F-box protein CORONATINE INSENSITIVE1 (COI1), part of the Skp1/Cullin/F-box SCF(COI1) ubiquitin E3 ligase complex.	Isoleucine	28-31	RNI-like superfamily protein	Arabidopsis thaliana	166-170
21859446-7	2011	Substitution of the asparagine at codon 348 in the p51 subunit with either isoleucine or leucine abrogated the observed protein-RNA interaction, thus, providing a possible explanation for the decreased RNase H phenotype.	Isoleucine	75-85	tumor protein p63	Homo sapiens	51-54
21835055-5	2011	RESULTS: We detected a heterozygous mutation in the first extracellular loop of the TSHR gene leading to an exchange of an isoleucine residue for asparagine at amino acid position 486 (I486N).	Isoleucine	123-133	thyroid stimulating hormone receptor	Homo sapiens	84-88
21620860-5	2011	The LIR motif of NBR1 presents differences to this classical LIR motif with a tyrosine residue and an isoleucine residue substituting the tryptophan residue and the leucine residue, respectively.	Isoleucine	102-112	NBR1 autophagy cargo receptor	Homo sapiens	17-21
21383035-18	2011	The combined addition of Val + Ile resulted in ADG that was intermediate between the PC and NC diets but not different from either diet (P &gt; 0.10); G:F was not improved (P &gt; 0.10) to that observed in pigs fed the PC diet.	Isoleucine	31-34	ADG	Sus scrofa	47-50
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Isoleucine	58-61	glutathione S-transferase pi 1	Homo sapiens	79-84
21476495-1	2011	Macrocyclic analogues of angiotensin IV (Ang IV, Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) targeting the insulin-regulated aminopeptidase (IRAP) have been designed, synthesized, and evaluated biologically.	Isoleucine	62-66	leucyl and cystinyl aminopeptidase	Homo sapiens	106-138
21601571-3	2011	In this study, a mammalian two-hybrid assay and competitive ELISA showed that the interaction between BRC repeat 4 (BRC4) and RAD51 was strengthened by the substitution of a single BRC4 amino acid from valine to isoleucine (V1532I).	Isoleucine	212-222	RAD51 recombinase	Homo sapiens	126-131
21682866-4	2011	METHODS: We designed a PAR-2-inhibiting peptide (PAR2-IP) by changing an isoleucine residue in the PAR-2-activating peptide (PAR2-AP), SLIGKV, to alanine, generating the SLAGKV peptide.	Isoleucine	73-83	F2R like trypsin receptor 1	Homo sapiens	23-28
21682866-4	2011	METHODS: We designed a PAR-2-inhibiting peptide (PAR2-IP) by changing an isoleucine residue in the PAR-2-activating peptide (PAR2-AP), SLIGKV, to alanine, generating the SLAGKV peptide.	Isoleucine	73-83	F2R like trypsin receptor 1	Homo sapiens	49-53
21682866-4	2011	METHODS: We designed a PAR-2-inhibiting peptide (PAR2-IP) by changing an isoleucine residue in the PAR-2-activating peptide (PAR2-AP), SLIGKV, to alanine, generating the SLAGKV peptide.	Isoleucine	73-83	F2R like trypsin receptor 1	Homo sapiens	99-104
21682866-4	2011	METHODS: We designed a PAR-2-inhibiting peptide (PAR2-IP) by changing an isoleucine residue in the PAR-2-activating peptide (PAR2-AP), SLIGKV, to alanine, generating the SLAGKV peptide.	Isoleucine	73-83	F2R like trypsin receptor 1	Homo sapiens	125-129
21497604-3	2011	Treatment with proteinase K eliminates these CTD signals, leaving only nonhelical signals from the Gln-rich and Asn-rich N-terminal segment, which are also observed in the solid-state NMR spectra of Ile-labeled fibrils formed by residues 1-89 of Ure2p.	Isoleucine	199-202	glutathione peroxidase	Saccharomyces cerevisiae S288C	246-251
21497604-5	2011	We additionally show that, after proteinase K treatment, Ile-labeled Ure2p fibrils formed without prion seeding exhibit a broader set of solid-state NMR signals than do prion-seeded fibrils, consistent with the idea that structural variations within the PD core account for prion strains.	Isoleucine	57-60	glutathione peroxidase	Saccharomyces cerevisiae S288C	69-74
21494553-7	2011	The computer-generated model was used to guide mutagenesis experiments, which support the notion that Leu-11 and possibly Ile-13 and Ile-14 of Ets-1 1-138 (Ets) make contributions through binding to the hydrophobic groove of the ERK2 D-recruiting site (DRS).	Isoleucine	122-125	ETS proto-oncogene 1, transcription factor	Homo sapiens	143-148
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Isoleucine	98-101	aspartate kinase	Saccharomyces cerevisiae S288C	133-135
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Isoleucine	98-101	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Isoleucine	98-101	aspartate kinase	Saccharomyces cerevisiae S288C	169-185
21279647-1	2011	Initial steps of aspartate-derived biosynthesis pathway (Asp pathway) producing Lys, Thr, Met and Ile are catalyzed by bifunctional (AK/HSD) and monofunctional (AK-lys) aspartate kinase (AK) enzymes.	Isoleucine	98-101	aspartate kinase	Saccharomyces cerevisiae S288C	161-163
21576464-4	2011	Metabolite analysis of wounded leaves showed that loss of CYP94B3 function in cyp94b3 mutants causes hyperaccumulation of JA-Ile and concomitant reduction in 12-hydroxy-JA-Ile (12OH-JA-Ile) content, whereas overexpression of this enzyme results in severe depletion of JA-Ile and corresponding changes in 12OH-JA-Ile levels.	Isoleucine	125-128	cytochrome P450, family 94, subfamily B, polypeptide 3	Arabidopsis thaliana	58-65
21576464-4	2011	Metabolite analysis of wounded leaves showed that loss of CYP94B3 function in cyp94b3 mutants causes hyperaccumulation of JA-Ile and concomitant reduction in 12-hydroxy-JA-Ile (12OH-JA-Ile) content, whereas overexpression of this enzyme results in severe depletion of JA-Ile and corresponding changes in 12OH-JA-Ile levels.	Isoleucine	125-128	cytochrome P450, family 94, subfamily B, polypeptide 3	Arabidopsis thaliana	78-85
21576464-4	2011	Metabolite analysis of wounded leaves showed that loss of CYP94B3 function in cyp94b3 mutants causes hyperaccumulation of JA-Ile and concomitant reduction in 12-hydroxy-JA-Ile (12OH-JA-Ile) content, whereas overexpression of this enzyme results in severe depletion of JA-Ile and corresponding changes in 12OH-JA-Ile levels.	Isoleucine	172-175	cytochrome P450, family 94, subfamily B, polypeptide 3	Arabidopsis thaliana	58-65
21576464-4	2011	Metabolite analysis of wounded leaves showed that loss of CYP94B3 function in cyp94b3 mutants causes hyperaccumulation of JA-Ile and concomitant reduction in 12-hydroxy-JA-Ile (12OH-JA-Ile) content, whereas overexpression of this enzyme results in severe depletion of JA-Ile and corresponding changes in 12OH-JA-Ile levels.	Isoleucine	172-175	cytochrome P450, family 94, subfamily B, polypeptide 3	Arabidopsis thaliana	78-85
21513285-9	2011	Further experiments showed that aromatic inhibitors of aggregation are as effective against Ile- and Leu-substituted versions of Abeta42 as they are against wild-type Abeta.	Isoleucine	92-95	amyloid beta precursor protein	Homo sapiens	129-134
21295118-3	2011	The shortest molecule which elicited most of the antidepressive effects was the tripeptide Ucn 3 (36-38), H-Ala-Gln-Ile-NH(2).	Isoleucine	116-119	urocortin 3	Mus musculus	91-96
21235540-7	2011	Administration of l-isoleucine induced a significant increase of beta-defensins 3 and 4 which was associated with decreased bacillary loads and tissue damage.	Isoleucine	18-30	defensin beta 3	Mus musculus	65-87
21494553-7	2011	The computer-generated model was used to guide mutagenesis experiments, which support the notion that Leu-11 and possibly Ile-13 and Ile-14 of Ets-1 1-138 (Ets) make contributions through binding to the hydrophobic groove of the ERK2 D-recruiting site (DRS).	Isoleucine	133-136	ETS proto-oncogene 1, transcription factor	Homo sapiens	143-148
21164104-2	2011	The 3 last residues of Na(v)1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex.	Isoleucine	37-40	sodium voltage-gated channel alpha subunit 5	Rattus norvegicus	23-31
21533077-7	2011	We could determine that the pathogenic molecular mechanism, induced by both the mouse and the human mutations, is a high frequency of abnormal folding of the tRNA(Ile) that cannot be charged with isoleucine.	Isoleucine	196-206	mitochondrially encoded tRNA glycine	Homo sapiens	158-162
21146516-5	2011	A third, hypomorphic allele, mitfa(z25) results in an isoleucine to phenylalanine substitution in the first helix domain of the protein.	Isoleucine	54-64	melanocyte inducing transcription factor a	Danio rerio	29-34
21164104-2	2011	The 3 last residues of Na(v)1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin-dystrophin complex.	Isoleucine	37-40	dystrophin	Rattus norvegicus	119-129
21257055-9	2011	In support of the increased yields of milk protein and lactose, mammary uptake of the group 2 AA (Ile, Leu, Lys, and Val) increased and the uptake:output ratio tended to increase from 1.04 to 1.23.	Isoleucine	98-101	Weaning weight-maternal milk	Bos taurus	38-42
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Isoleucine	144-154	prion like protein doppel	Homo sapiens	25-28
21169225-1	2011	Beneficial effects on body weight of supplementation with BCAA, including leucine, isoleucine, and valine, have been observed in animal and human studies.	Isoleucine	83-93	AT-rich interaction domain 4B	Homo sapiens	58-62
21081645-4	2011	We propose that the structural change of TM5 during the process of GPCR activation involves a local Pro(5.50)-induced unwinding of the helix, acting as a hinge, and the highly conserved hydrophobic Ile(3.40) side chain, acting as a pivot.	Isoleucine	198-201	tropomyosin 3	Homo sapiens	41-44
20929865-5	2011	Similar to other UBDs, UBMs bind to ubiquitin on the hydrophobic surface delineated by Leu-8, Ile-44, and Val-70, however, slightly shifted toward the C terminus.	Isoleucine	94-97	ubiquitin	Saccharomyces cerevisiae S288C	36-45
21088568-6	2011	SUMMARY: Recognizing hypoisoleucinemia and BCAA antagonism following gastrointestinal bleeding, and its successful treatment by isoleucine infusion has advanced our understanding of the role of BCAA in liver cirrhosis.	Isoleucine	25-35	AT-rich interaction domain 4B	Homo sapiens	194-198
21422519-6	2011	A novel mutation at codon 143 was found in PSEN1 gene, changing isoleucine to valine.	Isoleucine	64-74	presenilin 1	Homo sapiens	43-48
22041342-3	2011	The polymorphism, CCR2-V64I, changes valine 64 of CCR2 to isoleucine.	Isoleucine	58-68	C-C motif chemokine receptor 2	Homo sapiens	18-22
22041342-3	2011	The polymorphism, CCR2-V64I, changes valine 64 of CCR2 to isoleucine.	Isoleucine	58-68	C-C motif chemokine receptor 2	Homo sapiens	50-54
21698173-9	2011	CONCLUSIONS/SIGNIFICANCE: Our results suggest that TM5 (Ile-295, Gly-297) is in close proximity to TM8 (Ile-463) in the mammalian transporter, and that the spatial relationship between these domains is altered during the transport cycle.	Isoleucine	56-59	tropomyosin 3	Homo sapiens	51-54
21980421-3	2011	Currently, Glu314, Ser346, Lys347 and Lys362 in human c-NADP-ME were changed to the corresponding residues of human m-NAD(P)-ME (Glu, Lys, Tyr and Gln, respectively) or Ascaris suum m-NAD-ME (Ala, Ile, Asp and His, respectively).	Isoleucine	197-200	malic enzyme 1	Homo sapiens	56-63
21698173-9	2011	CONCLUSIONS/SIGNIFICANCE: Our results suggest that TM5 (Ile-295, Gly-297) is in close proximity to TM8 (Ile-463) in the mammalian transporter, and that the spatial relationship between these domains is altered during the transport cycle.	Isoleucine	56-59	tetraspanin 16	Homo sapiens	99-102
21698173-9	2011	CONCLUSIONS/SIGNIFICANCE: Our results suggest that TM5 (Ile-295, Gly-297) is in close proximity to TM8 (Ile-463) in the mammalian transporter, and that the spatial relationship between these domains is altered during the transport cycle.	Isoleucine	104-107	tropomyosin 3	Homo sapiens	51-54
21698173-9	2011	CONCLUSIONS/SIGNIFICANCE: Our results suggest that TM5 (Ile-295, Gly-297) is in close proximity to TM8 (Ile-463) in the mammalian transporter, and that the spatial relationship between these domains is altered during the transport cycle.	Isoleucine	104-107	tetraspanin 16	Homo sapiens	99-102
20213228-3	2010	This paper reports the case of a 38-year-old female showing early memory impairment and having a base pair mutation from guanine (G) to cytosine (C) at codon 139 of PSEN1, which leads to the substitution of a methionine with an isoleucine.	Isoleucine	228-238	presenilin 1	Homo sapiens	165-170
20813911-2	2010	It is hypothesized that the COOH-terminal isoleucine, I(382), could be substituted with any other bulky hydrophobic amino acid residue for LAMP-1 to exclusively localize in lysosomes.	Isoleucine	42-52	lysosomal associated membrane protein 1	Homo sapiens	139-145
21047126-2	2010	The angiotensin II metabolite angiotensin IV (Ang IV, Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) binds with high affinity to IRAP and inhibits this aminopeptidase (K(i) = 62.4 nM).	Isoleucine	68-71	leucyl and cystinyl aminopeptidase	Homo sapiens	125-129
20835484-1	2010	Pb-binding TAR-1 peptides (Ile-Ser-Leu-Leu-His-Ser-Thr) were covalently conjugated on a bolaamphiphile peptide nanotube substrate and the precursors of PbSe were incubated at room temperature.	Isoleucine	27-30	trace amine associated receptor 1	Homo sapiens	11-16
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Isoleucine	68-71	angiotensinogen	Homo sapiens	16-30
20977208-1	2010	The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases.	Isoleucine	68-71	angiogenin	Homo sapiens	32-35
20679339-2	2010	Matrix metalloproteinases (MMPs) cleave collagen after the Gly residue of the triplet sequence Gly~[Ile/Leu]-[Ala/Leu] at a single, unique, position along the peptide chain.	Isoleucine	100-103	matrix metallopeptidase 1	Homo sapiens	27-31
20888323-5	2010	Finally, a bioinformatics study reveals that the triplet amino acid homologies LLT (Leu-Leu-Thr) and AIS (Ala-Ile-Ser) in TM1 and TM3, respectively of the D2R-5-HT(2A)R may be involved in the receptor interface.	Isoleucine	110-113	tropomyosin 3	Homo sapiens	130-133
20809635-11	2010	The side chains of Pro and Ile of the octapeptide interact with the hydrophobic surface region of CTD site 2, which is broader and shallower than the concave binding region of site 1.	Isoleucine	27-30	CTD	Homo sapiens	98-101
20628052-2	2010	The most frequent cause of cystic fibrosis (CF) is the deletion of three nucleotides (CTT) from the cystic fibrosis transmembrane conductance regulator (CFTR) gene that includes the last cytosine (C) of isoleucine 507 (Ile507ATC) and the two thymidines (T) of phenylalanine 508 (Phe508TTT) codons.	Isoleucine	203-213	CF transmembrane conductance regulator	Homo sapiens	100-151
20729328-3	2010	We first generated an agonistic anti-hDectin-1 mAb, which recognizes the hDectin-1 Glu(143)-Ile(162) region.	Isoleucine	92-95	C-type lectin domain containing 7A	Homo sapiens	37-46
20729328-3	2010	We first generated an agonistic anti-hDectin-1 mAb, which recognizes the hDectin-1 Glu(143)-Ile(162) region.	Isoleucine	92-95	C-type lectin domain containing 7A	Homo sapiens	73-82
20630864-0	2010	Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2.	Isoleucine	48-58	PYR1-like 1	Arabidopsis thaliana	109-113
20630864-0	2010	Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2.	Isoleucine	48-58	PYR1-like 2	Arabidopsis thaliana	118-122
20630864-8	2010	Structural comparison and biochemical analyses demonstrated that one single amino acid alteration between a corresponding valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2.	Isoleucine	133-143	PYR1-like 1	Arabidopsis thaliana	194-198
20630864-8	2010	Structural comparison and biochemical analyses demonstrated that one single amino acid alteration between a corresponding valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2.	Isoleucine	133-143	PYR1-like 2	Arabidopsis thaliana	203-207
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Isoleucine	187-190	Fc gamma receptor and transporter	Homo sapiens	24-28
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Isoleucine	187-190	Fc gamma receptor and transporter	Homo sapiens	92-96
20592032-13	2010	Modeling of the peptide:FcRn structure as compared with available structural data on Fc and FcRn suggest that the His-6 and Phe-7 (peptide) partially mimic the interaction of His-310 and Ile-253 (Fc) in binding to FcRn, but using a different backbone topology.	Isoleucine	187-190	Fc gamma receptor and transporter	Homo sapiens	92-96
20871037-8	2010	Ile(114) and Arg(197), which are mutation sites of NAT2*4 to NAT2*5 and NAT2*6, were located in the peripheral part of the positive field.	Isoleucine	0-3	N-acetyltransferase 2	Homo sapiens	51-55
20871037-8	2010	Ile(114) and Arg(197), which are mutation sites of NAT2*4 to NAT2*5 and NAT2*6, were located in the peripheral part of the positive field.	Isoleucine	0-3	N-acetyltransferase 2	Homo sapiens	61-65
20871037-8	2010	Ile(114) and Arg(197), which are mutation sites of NAT2*4 to NAT2*5 and NAT2*6, were located in the peripheral part of the positive field.	Isoleucine	0-3	N-acetyltransferase 2	Homo sapiens	61-65
20799012-5	2010	A mutated GIP peptide in which Tyr(1), Ile(7), Asp(15), and His(18) were replaced by His, Thr, Glu, and Ala, respectively, was able to activate both GLP1R and GIPR with moderate potency.	Isoleucine	39-42	gastric inhibitory polypeptide	Homo sapiens	10-13
20799012-5	2010	A mutated GIP peptide in which Tyr(1), Ile(7), Asp(15), and His(18) were replaced by His, Thr, Glu, and Ala, respectively, was able to activate both GLP1R and GIPR with moderate potency.	Isoleucine	39-42	glucagon like peptide 1 receptor	Homo sapiens	149-154
20799012-6	2010	Replacing the original Tyr(1) and/or Ile(7) in the N-terminal moiety of this mutant peptide allowed full activation of GIPR but not of GLP1R.	Isoleucine	37-40	gastric inhibitory polypeptide receptor	Homo sapiens	119-123
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Isoleucine	42-45	gastric inhibitory polypeptide	Homo sapiens	56-59
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Isoleucine	42-45	glucagon	Homo sapiens	60-65
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Isoleucine	42-45	gastric inhibitory polypeptide receptor	Homo sapiens	121-125
20799012-8	2010	These results suggest that Tyr/His(1) and Ile/Thr(7) of GIP/GLP-1 peptides confer differential ligand selectivity toward GIPR and GLP1R.	Isoleucine	42-45	glucagon like peptide 1 receptor	Homo sapiens	130-135
20444690-3	2010	The key structural differences between this new structure and previously published structures are two new hydrogen bonds at positions Ile(37) and Glu(38) in strand C and Lys(66) in strand E, and a hydrophobic pocket around the center of the protein found in Ctid-beta2m.	Isoleucine	134-137	beta-2-microglobulin	Gallus gallus	263-269
20385563-6	2010	CPA4 was able to cleave hydrophobic C-terminal residues with a preference for Phe, Leu, Ile, Met, Tyr, and Val.	Isoleucine	88-91	carboxypeptidase A4	Homo sapiens	0-4
20465253-3	2010	The utility of the approach is demonstrated by an application to the folding reaction of a mutant Fyn SH3 domain, where Ile side-chain structure and dynamics of an on-folding pathway intermediate state are studied.	Isoleucine	120-123	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	98-101
20494390-6	2010	The results suggest that Ile 309 preserves a V3-mediated masking function that occludes the CD4 binding site.	Isoleucine	25-28	CD4 molecule	Homo sapiens	92-95
20477749-7	2010	A second cluster contained isoleucine and glutamate residues in place of phenylalanine and glutamine residues, residues that are best tolerated in Hgt1p for glutathione transporter activity, when introduced together.	Isoleucine	27-37	oligopeptide transporter OPT1	Saccharomyces cerevisiae S288C	147-152
20501330-1	2010	OBJECTIVES: To investigate the polymorphism distribution of Val-9Ala and Ile+58Thr of the Mn-superoxide dismutase (Mn-SOD) gene among subjects with Parkinson"s disease (PD) by analyses of genders and clinical severity.	Isoleucine	73-76	superoxide dismutase 2	Homo sapiens	90-113
20501330-1	2010	OBJECTIVES: To investigate the polymorphism distribution of Val-9Ala and Ile+58Thr of the Mn-superoxide dismutase (Mn-SOD) gene among subjects with Parkinson"s disease (PD) by analyses of genders and clinical severity.	Isoleucine	73-76	superoxide dismutase 2	Homo sapiens	115-121
20585391-5	2010	Mutation of F595 to Ala, Lys, Val or Ile significantly decreases the constitutive activity of JAK2 V617F, but F595W and F595Y are able to restore it, implying an aromaticity requirement at position 595.	Isoleucine	37-40	Janus kinase 2	Homo sapiens	94-98
20307531-4	2010	No polymorphism or splice variants have been reported for the rat neuropeptide S receptor, however it carries an isoleucine at position 107.	Isoleucine	113-123	neuropeptide S receptor 1	Rattus norvegicus	66-89
20395299-5	2010	Replacement of Val(362) with amino acid residues that disrupt the alpha-helical structure predicted by molecular modeling, such as arginine, glutamate, or phenylalanine, attenuated the stimulatory effects of Cx50 on lens differentiation, whereas replacement with threonine, isoleucine, leucine, or proline, which maintain the structure preserved the function of Cx50.	Isoleucine	274-284	gap junction protein alpha 8	Gallus gallus	208-212
20231286-8	2010	The introduction of these residues into the rat beta1 distal heme pocket (Ile-145 --&gt; Tyr and Ile-149 --&gt; Gln) resulted in an sGC construct that oxidized via an intermediate with an absorbance maximum at 417 nm.	Isoleucine	74-77	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	132-135
20231286-8	2010	The introduction of these residues into the rat beta1 distal heme pocket (Ile-145 --&gt; Tyr and Ile-149 --&gt; Gln) resulted in an sGC construct that oxidized via an intermediate with an absorbance maximum at 417 nm.	Isoleucine	97-100	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	132-135
20628052-2	2010	The most frequent cause of cystic fibrosis (CF) is the deletion of three nucleotides (CTT) from the cystic fibrosis transmembrane conductance regulator (CFTR) gene that includes the last cytosine (C) of isoleucine 507 (Ile507ATC) and the two thymidines (T) of phenylalanine 508 (Phe508TTT) codons.	Isoleucine	203-213	CF transmembrane conductance regulator	Homo sapiens	153-157
20471598-4	2010	Based on adsorption yield and residual activity of glutathione S-transferase (GST) after fusion with the PS19-6 peptide or its variants, it was found that the basic amino acid in the PS-tags, i.e., Arg was essential for the strong binding affinity of PS-tags in both the peptide and peptide-fused protein forms The aliphatic amino acids in PS19-6 and PS19-6L, such as Ile or Leu, were also effective.	Isoleucine	368-371	glutathione S-transferase kappa 1	Homo sapiens	78-81
20217205-3	2010	The unique Ile-324 mutation in the VP2 of Chinese CPV isolates was detected, as compared with a Tyr-324 in the VP2 of the reference CPV strains.	Isoleucine	11-14	VP2	Canine parvovirus	35-38
19048012-0	2010	A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia.	Isoleucine	15-25	pericentriolar material 1	Homo sapiens	51-76
19932771-6	2010	The catalytic domain of MMP-12 binds to the triple helix and cleaves the typical sites -Gly(775)-Leu(776)- in alpha-2 type I collagen and -Gly(775)-Ile(776)- in alpha-1 type I and type III collagens and at multiple other sites in both collagen types.	Isoleucine	148-151	matrix metallopeptidase 12	Homo sapiens	24-30
20308061-3	2010	Initially, hydrophobic LAP residues (Ile(53), Leu(54), Leu(57), and Leu(59)), which form a contiguous epitope on one surface of an amphipathic alpha-helix, interact with mature TGF-beta1 to form the small latent complex.	Isoleucine	37-40	transforming growth factor beta 1	Homo sapiens	23-26
20308061-3	2010	Initially, hydrophobic LAP residues (Ile(53), Leu(54), Leu(57), and Leu(59)), which form a contiguous epitope on one surface of an amphipathic alpha-helix, interact with mature TGF-beta1 to form the small latent complex.	Isoleucine	37-40	transforming growth factor beta 1	Homo sapiens	177-186
20495767-3	2010	Previous studies have shown that catalase binds to A-beta fibrils and appears to recognize a region containing the Gly-Ala-Ile-Ile sequence that is similar to the Gly-Ala-Ile-Leu sequence found in human IAPP residues 24-27.	Isoleucine	123-126	catalase	Homo sapiens	33-41
20495767-3	2010	Previous studies have shown that catalase binds to A-beta fibrils and appears to recognize a region containing the Gly-Ala-Ile-Ile sequence that is similar to the Gly-Ala-Ile-Leu sequence found in human IAPP residues 24-27.	Isoleucine	123-126	islet amyloid polypeptide	Homo sapiens	203-207
19882215-7	2010	The phosphorylation of ribosomal s6 kinase (p70S6K1) was increased by stimulation with all EAA with the exceptions of isoleucine and valine.	Isoleucine	118-128	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	44-51
20235117-10	2010	Results demonstrated that the peptide 3C (H-Tyr-Ile-Glu-Gly-Leu-Gln-Ala-Leu-Leu-Arg-Asp-Gln-NH(2)) not only showed high affinity for Id1 but also exhibited antiproliferative effects in HT-29 and MCF-7 cancer cells; the IC(50) value of 3C was determined as 25 microM in both cells.	Isoleucine	48-51	inhibitor of DNA binding 1, HLH protein	Homo sapiens	133-136
20156697-1	2010	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism affecting isoleucine catabolism and ketone body utilization.	Isoleucine	98-108	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38
19887450-5	2010	In addition, we identify six essential residues Tyr-87, Ile-97, Arg-99, Asn-103, Lys-105, and Lys-108 that define a compact HA-binding surface on Lyve-1, encompassing the epitope for an adhesion-blocking monoclonal antibody 3A, in an analogous position to the HA-binding surface in CD44.	Isoleucine	56-59	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	146-152
20345904-6	2010	With respect to the cleavage site specificities, the study revealed that all three MMPs similarly tolerate hydrophobic and/or aliphatic amino acids, including Pro, Gly, Ile, and Val, at P(1)".	Isoleucine	169-172	matrix metallopeptidase 7	Homo sapiens	83-87
20089773-0	2010	Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice.	Isoleucine	0-10	peroxisome proliferator activated receptor alpha	Mus musculus	95-104
20042600-2	2010	We had identified four residues (Tyr-63, Ile-66, Asp-69, and Gln-70), presumably contained in an alpha-helix, as a potential binding site for LPL.	Isoleucine	41-44	lipoprotein lipase	Homo sapiens	142-145
19747569-6	2010	The Ile residue at position 93 of ASTL is the first report in all C-type lysozymes.	Isoleucine	4-7	astacin-like metalloendopeptidase	Pelodiscus sinensis	34-38
19957998-6	2010	All the l-amino acid 3-HPG esters were effectively activated in HeLa and Caco-2 cell homogenates and were found to be good substrates of hVACVase (k(cat)/K(m) in mM(-1) x s(-1): Val-3-HPG, 3370; Ile-3-HPG, 1580; Phe-3-HPG, 1660).	Isoleucine	195-198	biphenyl hydrolase like	Homo sapiens	137-145
20019084-2	2010	neoformans ilv2 mutants die upon isoleucine and valine starvation.	Isoleucine	33-43	acetolactate synthase catalytic subunit	Saccharomyces cerevisiae S288C	11-15
20052711-5	2010	Analysis of the structural differences between the TEC and Src families of kinases near the Trp-Glu-Ile motif in the N-terminal region of the kinase domain suggests a mechanism of regulation of the TEC family members.	Isoleucine	100-103	tec protein tyrosine kinase	Homo sapiens	51-54
20052711-5	2010	Analysis of the structural differences between the TEC and Src families of kinases near the Trp-Glu-Ile motif in the N-terminal region of the kinase domain suggests a mechanism of regulation of the TEC family members.	Isoleucine	100-103	tec protein tyrosine kinase	Homo sapiens	198-201
20047279-7	2010	After phage display and repeated panning, we isolated a mutated scFv clone [scFv#m1-e7; Ile(L29)Val] that had 5-fold higher affinity (K(a) = 2.6 x 10(8) M(-1)) compared to the Ab#E4-4 Fab fragment (Fab#E4-4).	Isoleucine	88-91	immunglobulin heavy chain variable region	Homo sapiens	64-68
20047279-7	2010	After phage display and repeated panning, we isolated a mutated scFv clone [scFv#m1-e7; Ile(L29)Val] that had 5-fold higher affinity (K(a) = 2.6 x 10(8) M(-1)) compared to the Ab#E4-4 Fab fragment (Fab#E4-4).	Isoleucine	88-91	immunglobulin heavy chain variable region	Homo sapiens	76-80
20047279-7	2010	After phage display and repeated panning, we isolated a mutated scFv clone [scFv#m1-e7; Ile(L29)Val] that had 5-fold higher affinity (K(a) = 2.6 x 10(8) M(-1)) compared to the Ab#E4-4 Fab fragment (Fab#E4-4).	Isoleucine	88-91	FA complementation group B	Homo sapiens	184-187
20047279-7	2010	After phage display and repeated panning, we isolated a mutated scFv clone [scFv#m1-e7; Ile(L29)Val] that had 5-fold higher affinity (K(a) = 2.6 x 10(8) M(-1)) compared to the Ab#E4-4 Fab fragment (Fab#E4-4).	Isoleucine	88-91	FA complementation group B	Homo sapiens	198-201
19773194-1	2010	A functional variant in the Histamine N-Methyltransferase gene (HNMT - rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation.	Isoleucine	111-121	histamine N-methyltransferase	Homo sapiens	28-57
19858196-6	2010	Isoleucine and valine are not allosteric activators of GDH1, but in the presence of 5"-phosphate-BCATm, they convert BCATm to PMP-BCATm, stimulating GDH1 activity.	Isoleucine	0-10	branched chain amino acid transaminase 2	Homo sapiens	97-102
19773194-1	2010	A functional variant in the Histamine N-Methyltransferase gene (HNMT - rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation.	Isoleucine	111-121	histamine N-methyltransferase	Homo sapiens	64-68
19858196-6	2010	Isoleucine and valine are not allosteric activators of GDH1, but in the presence of 5"-phosphate-BCATm, they convert BCATm to PMP-BCATm, stimulating GDH1 activity.	Isoleucine	0-10	branched chain amino acid transaminase 2	Homo sapiens	117-122
19858196-6	2010	Isoleucine and valine are not allosteric activators of GDH1, but in the presence of 5"-phosphate-BCATm, they convert BCATm to PMP-BCATm, stimulating GDH1 activity.	Isoleucine	0-10	branched chain amino acid transaminase 2	Homo sapiens	126-135
19858196-6	2010	Isoleucine and valine are not allosteric activators of GDH1, but in the presence of 5"-phosphate-BCATm, they convert BCATm to PMP-BCATm, stimulating GDH1 activity.	Isoleucine	0-10	glutamate dehydrogenase 1	Homo sapiens	149-153
19506924-5	2010	In particular the replacement of serine 256 and isoleucine 359 in LeuT(Aa) with glycine and threonine in hGAT-1 seems to facilitate the selection of GABA as the main substrate by changing the hydrogen bonding pattern in the active site to the amino group of the substrate.	Isoleucine	48-58	Leucine transport, high	Homo sapiens	66-70
20083051-11	2010	In the CPT II gene, the subject was found to be heterozygous for an amino acid substitution in exon 4, (1203)G&gt;A causing a (368)Val&gt;Ile amino acid substitution.	Isoleucine	138-141	carnitine palmitoyltransferase 2	Homo sapiens	7-13
19506924-5	2010	In particular the replacement of serine 256 and isoleucine 359 in LeuT(Aa) with glycine and threonine in hGAT-1 seems to facilitate the selection of GABA as the main substrate by changing the hydrogen bonding pattern in the active site to the amino group of the substrate.	Isoleucine	48-58	solute carrier family 6 member 1	Homo sapiens	105-111
20013305-2	2010	As the most unique member of human CYP2C family, CYP2C8 has an isoleucine (Ile) 476 instead of phenylalanine (Phe) in substrate recognizing site 6 (SRS6).	Isoleucine	63-73	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	49-55
20013305-2	2010	As the most unique member of human CYP2C family, CYP2C8 has an isoleucine (Ile) 476 instead of phenylalanine (Phe) in substrate recognizing site 6 (SRS6).	Isoleucine	75-78	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	49-55
19674967-5	2009	The receptor accommodates the altered binding modes by shifting the side chain conformations of two residues within the binding groove: Leu-41 and Ile-115, the former acting as a rotamer toggle switch to accommodate PTH/PTHrP sequence divergence, and the latter adapting to the PTHrP curvature.	Isoleucine	147-150	parathyroid hormone	Homo sapiens	216-219
20733278-3	2010	Genetic investigation of the SRY and MAMLD1 coding sequences revealed a normal SRY sequence and a mutation in the MAMLD1 gene sequence: a homozygous change (C&gt;A) was found, leading to the synthesis of an isoleucine, instead of a leucine.	Isoleucine	207-217	sex-determining region Y protein	Equus caballus	29-32
20733278-3	2010	Genetic investigation of the SRY and MAMLD1 coding sequences revealed a normal SRY sequence and a mutation in the MAMLD1 gene sequence: a homozygous change (C&gt;A) was found, leading to the synthesis of an isoleucine, instead of a leucine.	Isoleucine	207-217	mastermind like domain containing 1	Equus caballus	37-43
20733278-3	2010	Genetic investigation of the SRY and MAMLD1 coding sequences revealed a normal SRY sequence and a mutation in the MAMLD1 gene sequence: a homozygous change (C&gt;A) was found, leading to the synthesis of an isoleucine, instead of a leucine.	Isoleucine	207-217	mastermind like domain containing 1	Equus caballus	114-120
20011099-6	2009	This patient harbors an isoleucine to asparagine mutation (I304N) in the second FMRP KH-type RNA-binding domain, however, this single case report was complicated because the patient harbored a superimposed familial liver disease.	Isoleucine	24-34	fragile X messenger ribonucleoprotein 1	Homo sapiens	80-84
19951175-1	2009	In bovine Mx1, only an amino acid substitution between Ile and Met at position 120 was detected by the nucleotide sequence and mismatched PCR-RFLP technique.	Isoleucine	55-58	MX dynamin like GTPase 1	Bos taurus	10-13
19732751-4	2009	Sequence analysis of complete mitochondrial genomes in these pedigrees showed the homoplasmic T14502C (I58V) mutation, which localized at a highly conserved isoleucine at position 58 of ND6, and distinct sets of mtDNA polymorphisms belonging to haplogroups M10a, F1a1, and H2.	Isoleucine	157-167	mitochondrially encoded NADH dehydrogenase 6	Homo sapiens	186-189
19845901-1	2009	The full-length sequence of HLA-B*5417 differs from HLA-B*5401 only by single-nucleotide change at nt 709 where A--&gt;C resulting in a amino acid substitution from Ile (ATC) to Val (GTC) at codon 213 in exon 4.	Isoleucine	165-168	major histocompatibility complex, class I, B	Homo sapiens	28-33
19845901-1	2009	The full-length sequence of HLA-B*5417 differs from HLA-B*5401 only by single-nucleotide change at nt 709 where A--&gt;C resulting in a amino acid substitution from Ile (ATC) to Val (GTC) at codon 213 in exon 4.	Isoleucine	165-168	major histocompatibility complex, class I, B	Homo sapiens	52-57
19859543-5	2009	We identified two important variants: (i) a frameshift mutation (P(229)fs) that generates a truncated, constitutively active receptor and (ii) a serine to isoleucine mutation (S(183)I), which drastically inhibits antiviral signaling and exerts a down-regulatory effect, due to unintended stable complexes of RIG-I with itself and with MAVS, a key downstream adapter protein.	Isoleucine	155-165	DExD/H-box helicase 58	Homo sapiens	308-313
19859543-5	2009	We identified two important variants: (i) a frameshift mutation (P(229)fs) that generates a truncated, constitutively active receptor and (ii) a serine to isoleucine mutation (S(183)I), which drastically inhibits antiviral signaling and exerts a down-regulatory effect, due to unintended stable complexes of RIG-I with itself and with MAVS, a key downstream adapter protein.	Isoleucine	155-165	mitochondrial antiviral signaling protein	Homo sapiens	335-339
19808963-10	2009	One such difference is the presence of Ile(104) in GSTP1-1 close to the bound NBDHEX, whereas the corresponding position is occupied by an alanine in GSTM2-2.	Isoleucine	39-42	glutathione S-transferase pi 1	Homo sapiens	51-58
19875446-7	2009	Site-directed mutagenesis of GLYT2 EL4 residues was used to identify the key residues Arg(531), Lys(532), and Ile(545) that contribute to the differences in NAGly sensitivity.	Isoleucine	110-113	solute carrier family 6 member 5	Rattus norvegicus	29-34
19674967-5	2009	The receptor accommodates the altered binding modes by shifting the side chain conformations of two residues within the binding groove: Leu-41 and Ile-115, the former acting as a rotamer toggle switch to accommodate PTH/PTHrP sequence divergence, and the latter adapting to the PTHrP curvature.	Isoleucine	147-150	parathyroid hormone like hormone	Homo sapiens	220-225
19674967-5	2009	The receptor accommodates the altered binding modes by shifting the side chain conformations of two residues within the binding groove: Leu-41 and Ile-115, the former acting as a rotamer toggle switch to accommodate PTH/PTHrP sequence divergence, and the latter adapting to the PTHrP curvature.	Isoleucine	147-150	parathyroid hormone like hormone	Homo sapiens	278-283
19665280-3	2009	In this study, we changed specific residue Val-76 in the selectivity filter of KcsA to its counterpart Ile in inwardly rectifying K(+)-channels (Kir).	Isoleucine	103-106	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	145-148
19651772-9	2009	Importantly, activation of mutant AMPK by LKB1 was restored by exchanging the corresponding and conserved hydrophobic alphaG-helix residues of LKB1 (Ile-260 and Phe-264) to positively charged amino acids.	Isoleucine	149-152	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	34-38
19651772-9	2009	Importantly, activation of mutant AMPK by LKB1 was restored by exchanging the corresponding and conserved hydrophobic alphaG-helix residues of LKB1 (Ile-260 and Phe-264) to positively charged amino acids.	Isoleucine	149-152	serine/threonine kinase 11	Homo sapiens	42-46
19651772-9	2009	Importantly, activation of mutant AMPK by LKB1 was restored by exchanging the corresponding and conserved hydrophobic alphaG-helix residues of LKB1 (Ile-260 and Phe-264) to positively charged amino acids.	Isoleucine	149-152	serine/threonine kinase 11	Homo sapiens	143-147
19507198-3	2009	Based on homology studies and the crystal structure of the NADP(H)-dependent yeast alcohol dehydrogenase Adh6, three adjacent residues (Glu(221), Ile(222), and Ala(223)) were predicted to be involved in the coenzyme specificity of Bdh1 and were altered by site-directed mutagenesis.	Isoleucine	146-149	NADP-dependent alcohol dehydrogenase	Saccharomyces cerevisiae S288C	105-109
19507198-3	2009	Based on homology studies and the crystal structure of the NADP(H)-dependent yeast alcohol dehydrogenase Adh6, three adjacent residues (Glu(221), Ile(222), and Ala(223)) were predicted to be involved in the coenzyme specificity of Bdh1 and were altered by site-directed mutagenesis.	Isoleucine	146-149	(R,R)-butanediol dehydrogenase	Saccharomyces cerevisiae S288C	231-235
19549636-7	2009	This demonstration of the functional consequences of the fH-Ile(62) polymorphism provides relevant insights into the complement regulatory activities of fH that will be useful in disease prediction and future development of effective therapeutics for disorders caused by complement dysregulation.	Isoleucine	60-63	complement factor H	Homo sapiens	57-59
19549636-7	2009	This demonstration of the functional consequences of the fH-Ile(62) polymorphism provides relevant insights into the complement regulatory activities of fH that will be useful in disease prediction and future development of effective therapeutics for disorders caused by complement dysregulation.	Isoleucine	60-63	complement factor H	Homo sapiens	153-155
19300427-6	2009	In a subset of 147 men, carriers of the Ile variant showed significantly increased insulin sensitivity.	Isoleucine	40-43	insulin	Homo sapiens	83-90
19300427-9	2009	In agreement with these results, the adipose tissue FASN activity was significantly lower in subjects with the Ile variant (P = 0.01).	Isoleucine	111-114	fatty acid synthase	Homo sapiens	52-56
19300427-10	2009	In summary, adult white men with the Ile 1483 variant of the FASN gene seem protected from developing central obesity through decreased adipose tissue FASN activity.	Isoleucine	37-40	fatty acid synthase	Homo sapiens	61-65
19300427-10	2009	In summary, adult white men with the Ile 1483 variant of the FASN gene seem protected from developing central obesity through decreased adipose tissue FASN activity.	Isoleucine	37-40	fatty acid synthase	Homo sapiens	151-155
19706438-0	2009	Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism.	Isoleucine	94-104	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	46-54
19571310-0	2009	Arabidopsis methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinate role to threonine deaminase.	Isoleucine	61-71	methionine gamma-lyase	Arabidopsis thaliana	12-34
19571310-2	2009	However, demonstration of methionine gamma-lyase (MGL) activity in Arabidopsis (Arabidopsis thaliana) suggested that production of 2-ketobutyrate from methionine can also lead to isoleucine biosynthesis.	Isoleucine	179-189	methionine gamma-lyase	Arabidopsis thaliana	26-48
19536136-5	2009	Both UIM1 and UIM2 of RAP80 recognize an Ile 44-centered hydrophobic patch on ubiquitin but neither UIM interacts with the Lys 63-linked isopeptide bond.	Isoleucine	41-44	ubiquitin interaction motif containing 1	Homo sapiens	22-27
19571310-2	2009	However, demonstration of methionine gamma-lyase (MGL) activity in Arabidopsis (Arabidopsis thaliana) suggested that production of 2-ketobutyrate from methionine can also lead to isoleucine biosynthesis.	Isoleucine	179-189	methionine gamma-lyase	Arabidopsis thaliana	50-53
19571310-4	2009	In mgl mutant flowers and seeds, methionine levels are significantly increased and incorporation of [(13)C]Met into isoleucine is decreased, but isoleucine levels are unaffected.	Isoleucine	116-126	methionine gamma-lyase	Arabidopsis thaliana	3-6
19571310-4	2009	In mgl mutant flowers and seeds, methionine levels are significantly increased and incorporation of [(13)C]Met into isoleucine is decreased, but isoleucine levels are unaffected.	Isoleucine	145-155	methionine gamma-lyase	Arabidopsis thaliana	3-6
19618964-6	2009	Moreover, sequence analysis identifies a similar actin-binding motif in the N-terminus of the RhoGEF frabin, and as with PDZ-RhoGEF, mutagenesis and actin interaction experiments demonstrate an LIxxFE motif, consisting of the key amino acids leucine 23, isoleucine 24, phenylalanine 27, and glutamic acid 28.	Isoleucine	254-264	Rho guanine nucleotide exchange factor 11	Homo sapiens	121-131
19577562-1	2009	The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of beta1 chain, is known to inhibit tumor growth and metastasis.	Isoleucine	21-31	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	114-119
18849186-2	2009	HER-2 codon 655 polymorphism, either isoleucine (Ile: ATC) or valine (Val: GTC), was associated with the risk of breast carcinoma.	Isoleucine	37-47	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
19302372-7	2009	Consistent with this, GCN4 expression was reduced by isoleucine and valine.	Isoleucine	53-63	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	22-26
19525230-6	2009	We also show that the Hxk2 nuclear export and the binding of Hxk2 and Xpo1 involve two leucine-rich nuclear export signals (NES) located between leucine 23 and isoleucine 33 (NES1) and between leucine 310 and leucine 318 (NES2).	Isoleucine	160-170	hexokinase 2	Saccharomyces cerevisiae S288C	22-26
19525230-6	2009	We also show that the Hxk2 nuclear export and the binding of Hxk2 and Xpo1 involve two leucine-rich nuclear export signals (NES) located between leucine 23 and isoleucine 33 (NES1) and between leucine 310 and leucine 318 (NES2).	Isoleucine	160-170	hexokinase 2	Saccharomyces cerevisiae S288C	61-65
19401154-4	2009	FhcatB1 has biochemical properties distinct from mammalian cathepsin B enzymes, with an atypical preference for Ile over Leu or Arg residues at the P(2) substrate position and an inability to act as an exopeptidase.	Isoleucine	112-115	cathepsin B	Homo sapiens	59-70
19459151-4	2009	Characterization of ste2 yeast overexpressing Ste2p variants indicated that residues Ile 24 and Ile 29 as well as Pro 15 are critical in mediating mating efficiency.	Isoleucine	85-88	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	20-24
19459151-4	2009	Characterization of ste2 yeast overexpressing Ste2p variants indicated that residues Ile 24 and Ile 29 as well as Pro 15 are critical in mediating mating efficiency.	Isoleucine	85-88	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	46-51
19557636-2	2009	T315I (Treonine--&gt;Isoleucine) is a mutation in the exon 6 of BCR-ABL gene that makes the protein resistant to kinase inhibitors currently used for treating CML.	Isoleucine	21-31	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	64-71
19561616-3	2009	We demonstrate that the Bdkrb1 agonist R838 (Sar-[D-Phe]des-Arg(9)-bradykinin) markedly decreases the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in SJL mice, whereas the Bdkrb1 antagonist R715 (Ac-Lys-[D-betaNal(7), Ile(8)]des-Arg(9)-bradykinin) resulted in earlier onset and greater severity of the disease.	Isoleucine	242-245	bradykinin receptor, beta 1	Mus musculus	24-30
19341824-4	2009	Variants of the p19 protein were created at locations C110, C134 and C160 where the cysteines were replaced by an inert amino acid such as serine or isoleucine.	Isoleucine	149-159	interleukin 23 subunit alpha	Homo sapiens	16-19
19447100-9	2009	Ile(225) is highly conserved among species and this mutation is predicted to impair function of the mature LPL protein.	Isoleucine	0-3	lipoprotein lipase	Homo sapiens	107-110
19525230-6	2009	We also show that the Hxk2 nuclear export and the binding of Hxk2 and Xpo1 involve two leucine-rich nuclear export signals (NES) located between leucine 23 and isoleucine 33 (NES1) and between leucine 310 and leucine 318 (NES2).	Isoleucine	160-170	exportin CRM1	Saccharomyces cerevisiae S288C	70-74
19447885-6	2009	Electrophysiological studies showed that the key residues for functional activity are Asp(5)-Arg(7) and Asp(11)-Ile(15), because changes at these positions resulted in the loss of activity at the alpha9alpha10 nAChR.	Isoleucine	112-115	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	210-215
19473979-7	2009	This motif is located within the L16 extension lying C-terminal to the CD domain in ERK3 and ERK4 and a single isoleucine to lysine substitution in FRIEDE totally abrogates binding, activation, and translocation of MK5 by both ERK3 and ERK4.	Isoleucine	111-121	immunoglobulin kappa variable 3D-15	Homo sapiens	33-36
19473979-7	2009	This motif is located within the L16 extension lying C-terminal to the CD domain in ERK3 and ERK4 and a single isoleucine to lysine substitution in FRIEDE totally abrogates binding, activation, and translocation of MK5 by both ERK3 and ERK4.	Isoleucine	111-121	MAPK activated protein kinase 5	Homo sapiens	215-218
19469484-5	2009	The SBi279 binding site on Ca(2+)-S100B overlaps the SBi132 and SBi523 sites and contacts residues in both loop 2 (Ser-41, His-42, Phe-43, Leu-44, and Glu-45) and helix 4 (Ile-80, Ala-83, Cys-84, Phe-87, and Phe-88).	Isoleucine	172-175	S100 calcium binding protein B	Homo sapiens	34-39
18849186-2	2009	HER-2 codon 655 polymorphism, either isoleucine (Ile: ATC) or valine (Val: GTC), was associated with the risk of breast carcinoma.	Isoleucine	49-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
19712949-8	2009	C-11 binds to BGAF, indicating that the Ile(72)-Thr(82) region is indeed a major interaction site on Glu1 involved in BGAF binding.	Isoleucine	40-43	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	Zea mays	101-105
19557178-11	2009	In human ERalpha, the corresponding residue Ile-424 has a van der Waals contact with 15alpha-OH-E2.	Isoleucine	44-47	estrogen receptor 1	Homo sapiens	9-16
19459151-4	2009	Characterization of ste2 yeast overexpressing Ste2p variants indicated that residues Ile 24 and Ile 29 as well as Pro 15 are critical in mediating mating efficiency.	Isoleucine	96-99	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	20-24
19459151-4	2009	Characterization of ste2 yeast overexpressing Ste2p variants indicated that residues Ile 24 and Ile 29 as well as Pro 15 are critical in mediating mating efficiency.	Isoleucine	96-99	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	46-51
19712949-5	2009	The results showed that a region spanning 11 amino acids (Ile(72)-Thr(82)) on Glu1 is essential and sufficient for BGAF binding, whereas the extreme N-terminal region Ser(1)-Thr(29), together with C-terminal region Phe(466)-Ala(512), affects the size of Glu1-BGAF complexes.	Isoleucine	58-61	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic	Zea mays	78-82
19515926-4	2009	Abeta peptides with alanine or isoleucine substitutions of G33 displayed an increased propensity to form higher oligomers, which we could attribute to conformational changes.	Isoleucine	31-41	amyloid beta precursor protein	Homo sapiens	0-5
19435302-1	2009	The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP).	Isoleucine	18-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
19953880-6	2009	The substitution of Val to Ile at the amino acid residue 297 led to an increased equilibrium dissolved constant between VEGF and its receptor VEGFR-2 [297Val (87 +/- 9) pmol/L versus 297Ile (195 +/- 36) pmol/L, P &lt; 0.01].	Isoleucine	27-30	vascular endothelial growth factor A	Homo sapiens	120-124
19953880-6	2009	The substitution of Val to Ile at the amino acid residue 297 led to an increased equilibrium dissolved constant between VEGF and its receptor VEGFR-2 [297Val (87 +/- 9) pmol/L versus 297Ile (195 +/- 36) pmol/L, P &lt; 0.01].	Isoleucine	27-30	kinase insert domain receptor	Homo sapiens	142-149
19366703-9	2009	Specifically, substitutions to hydrophobic amino acids Ile, Leu, and Val, equivalent to those found in other VEGFs, most favorably affected the activity of the recombinant VEGF-D(DeltaNDeltaC).	Isoleucine	55-58	vascular endothelial growth factor D	Homo sapiens	172-192
19435302-1	2009	The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP).	Isoleucine	18-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
19435302-1	2009	The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP).	Isoleucine	18-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
19358546-6	2009	With Cc0300, substrates terminating in isoleucine, leucine, phenylalanine, tyrosine, valine, methionine, and tryptophan were hydrolyzed.	Isoleucine	39-49	amidohydrolase family protein	Caulobacter vibrioides CB15	5-11
19244403-8	2009	In the Val(5)-ANG II-infused rats, the plasma Ile(5)-ANG II levels increased 196.2 +/- 70.1% compared with sham plasma Ile(5)-ANG II concentration.	Isoleucine	46-49	angiotensinogen	Rattus norvegicus	14-20
19499991-14	2009	By contrast, isoleucine 635, located in the sixth transmembrane domain, is important in regulating TSH receptor basal activity but does not modify its plasma membrane expression.	Isoleucine	13-23	thyroid stimulating hormone receptor	Homo sapiens	99-111
19451643-6	2009	M53A ClpS is known to mediate degradation of an expanded repertoire of substrates, including those with N-terminal valine or isoleucine.	Isoleucine	125-135	colipase	Homo sapiens	5-9
19244403-8	2009	In the Val(5)-ANG II-infused rats, the plasma Ile(5)-ANG II levels increased 196.2 +/- 70.1% compared with sham plasma Ile(5)-ANG II concentration.	Isoleucine	46-49	angiotensinogen	Rattus norvegicus	53-59
19244403-8	2009	In the Val(5)-ANG II-infused rats, the plasma Ile(5)-ANG II levels increased 196.2 +/- 70.1% compared with sham plasma Ile(5)-ANG II concentration.	Isoleucine	46-49	angiotensinogen	Rattus norvegicus	53-59
19452316-3	2009	Here, we examined whether an FcgammaRIIb 232 isoleucine (I)/threonine (T) polymorphism predicts rituximab response in 101 patients with follicular lymphoma.	Isoleucine	45-55	Fc gamma receptor IIb	Homo sapiens	29-40
19283487-5	2009	The side chains of P4 Ile and Tyr form hydrophobic interactions with caspase-3 residues Trp206 and Trp214 within a non-polar pocket of the S4 subsite, while P4 Trp interacts with Phe250 and Phe252 that can also form the S5 subsite.	Isoleucine	22-25	caspase 3	Homo sapiens	69-78
19366592-3	2009	The functional role of Ile(287) in human GLUT1, which corresponds to Asn(331) in Hxt2, was studied by its replacement with each of the other 19 amino acids.	Isoleucine	23-26	solute carrier family 2 member 1	Homo sapiens	41-46
19366592-3	2009	The functional role of Ile(287) in human GLUT1, which corresponds to Asn(331) in Hxt2, was studied by its replacement with each of the other 19 amino acids.	Isoleucine	23-26	hexose transporter HXT2	Saccharomyces cerevisiae S288C	81-85
19366592-8	2009	These results suggest that Ile(287) is a key residue for maintaining high glucose affinity in GLUT1 as revealed in Hxt2 and is located at or near the exofacial glucose binding site.	Isoleucine	27-30	solute carrier family 2 member 1	Homo sapiens	94-99
19366592-8	2009	These results suggest that Ile(287) is a key residue for maintaining high glucose affinity in GLUT1 as revealed in Hxt2 and is located at or near the exofacial glucose binding site.	Isoleucine	27-30	hexose transporter HXT2	Saccharomyces cerevisiae S288C	115-119
19236053-6	2009	Inserted into the Hsp90 of yeast, this conservative leucine to isoleucine substitution recreated this lowered affinity for RAD in vitro.	Isoleucine	63-73	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	18-23
18584305-3	2009	Sequence analysis revealed that mtIQ1 protein is a new member of calmodulin (CaM) binding protein families with conserved Ile and Gln residues (IQ motif).	Isoleucine	122-125	IQ motif containing F4	Mus musculus	32-37
19116209-7	2009	Active MMP-9 cleaved a single peptide, ECVKGPNVAAIVGGT, at residues corresponding to Ala(705) and Ile(706) of the beta(2) integrin.	Isoleucine	98-101	matrix metallopeptidase 9	Homo sapiens	7-12
19236053-8	2009	Co-crystal structures reveal that the change to isoleucine is associated with a localized increase in the hydration of an Hsp90-bound RAD but not GdA.	Isoleucine	48-58	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	122-127
19090790-7	2009	In addition, the corresponding isoleucine residue (Ile155) of the p47phox homologue Noxo1 (Nox organizer 1) participates in the activation of non-phagocytic oxidases, such as Nox1 and Nox3.	Isoleucine	31-41	neutrophil cytosolic factor 1	Homo sapiens	66-73
19090790-7	2009	In addition, the corresponding isoleucine residue (Ile155) of the p47phox homologue Noxo1 (Nox organizer 1) participates in the activation of non-phagocytic oxidases, such as Nox1 and Nox3.	Isoleucine	31-41	NADPH oxidase organizer 1	Homo sapiens	84-89
19090790-7	2009	In addition, the corresponding isoleucine residue (Ile155) of the p47phox homologue Noxo1 (Nox organizer 1) participates in the activation of non-phagocytic oxidases, such as Nox1 and Nox3.	Isoleucine	31-41	NADPH oxidase organizer 1	Homo sapiens	91-106
19090790-7	2009	In addition, the corresponding isoleucine residue (Ile155) of the p47phox homologue Noxo1 (Nox organizer 1) participates in the activation of non-phagocytic oxidases, such as Nox1 and Nox3.	Isoleucine	31-41	NADPH oxidase 1	Homo sapiens	175-179
19090790-7	2009	In addition, the corresponding isoleucine residue (Ile155) of the p47phox homologue Noxo1 (Nox organizer 1) participates in the activation of non-phagocytic oxidases, such as Nox1 and Nox3.	Isoleucine	31-41	NADPH oxidase 3	Homo sapiens	184-188
19211556-9	2009	The crystal structure at 1.7-A resolution revealed that the dual mutation causes a shift of residue Gly(96) toward the glyphosate binding site, impairing efficient binding of glyphosate, while the side chain of Ile(97) points away from the substrate binding site, facilitating PEP utilization.	Isoleucine	211-214	phosphoenolpyruvate carboxylase 2	Zea mays	277-280
19171938-7	2009	Mutation of three consecutive hydrophobic residues (Phe(1520)-Ile(1521)-Phe(1522)) to alanines in this CaM-binding domain recapitulated the electrophysiology phenotype observed with mutation of the C-terminal IQ domain: Na(V)1.5 inactivation was stabilized; moreover, mutations of either CaM-binding domain abolish the well described stabilization of inactivation by lidocaine.	Isoleucine	62-65	calmodulin 1	Homo sapiens	103-106
19371218-3	2009	I219V Polymorphism is located on exon 8 of hMLH1 and provides an aminoacidic substitution of isoleucine to valine, on the protein codon 219.	Isoleucine	93-103	mutL homolog 1	Homo sapiens	43-48
19171938-7	2009	Mutation of three consecutive hydrophobic residues (Phe(1520)-Ile(1521)-Phe(1522)) to alanines in this CaM-binding domain recapitulated the electrophysiology phenotype observed with mutation of the C-terminal IQ domain: Na(V)1.5 inactivation was stabilized; moreover, mutations of either CaM-binding domain abolish the well described stabilization of inactivation by lidocaine.	Isoleucine	62-65	immunoglobulin lambda variable 2-18	Homo sapiens	220-228
19171938-7	2009	Mutation of three consecutive hydrophobic residues (Phe(1520)-Ile(1521)-Phe(1522)) to alanines in this CaM-binding domain recapitulated the electrophysiology phenotype observed with mutation of the C-terminal IQ domain: Na(V)1.5 inactivation was stabilized; moreover, mutations of either CaM-binding domain abolish the well described stabilization of inactivation by lidocaine.	Isoleucine	62-65	calmodulin 1	Homo sapiens	288-291
19106102-2	2009	The activating cleavage step at Ser(43) downward arrow Ile(44) in mouse pro-Crp4-(20-92) removes nine acidic amino acids that collectively block the membrane-disruptive behavior of the Crp4 moiety of the proform.	Isoleucine	55-58	defensin, alpha, 4	Mus musculus	76-80
19106102-2	2009	The activating cleavage step at Ser(43) downward arrow Ile(44) in mouse pro-Crp4-(20-92) removes nine acidic amino acids that collectively block the membrane-disruptive behavior of the Crp4 moiety of the proform.	Isoleucine	55-58	defensin, alpha, 4	Mus musculus	185-189
19708161-4	2009	The general acid/base mechanism utilized by PS1 is divided into the following two steps: (1) formation of the gem-diol intermediate, and (2) cleavage of the Val-Ile or Ala-Thr peptide bond.	Isoleucine	161-164	presenilin 1	Homo sapiens	44-47
19181668-6	2009	It is isoleucine 75 in the case of thioredoxin.	Isoleucine	6-16	thioredoxin	Homo sapiens	35-46
18939944-7	2009	NMR analysis of the c-IAP1 UBA domain-ubiquitin interaction reveals that this UBA domain binds the classical hydrophobic patch surrounding Ile(44) of ubiquitin.	Isoleucine	139-142	baculoviral IAP repeat containing 2	Homo sapiens	20-26
19176456-2	2009	Patients who become resistant to imatinib treatment often develop secondary mutations, the most common of which results in a substitution of isoleucine for threonine at the same location in the ATP-binding domain in all three kinases (in KIT this occurs at amino acid 670).	Isoleucine	141-151	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	238-241
19708161-1	2009	In this combined bioinformatics, molecular dynamics (MD), and density functional theory study, mechanisms for the hydrolytic cleavage of Val-Ile and Ala-Thr peptide bonds of amyloid precursor protein by the intramembrane aspartyl protease presenilin 1 (PS1) have been elucidated.	Isoleucine	141-144	amyloid beta precursor protein	Homo sapiens	174-199
19708161-1	2009	In this combined bioinformatics, molecular dynamics (MD), and density functional theory study, mechanisms for the hydrolytic cleavage of Val-Ile and Ala-Thr peptide bonds of amyloid precursor protein by the intramembrane aspartyl protease presenilin 1 (PS1) have been elucidated.	Isoleucine	141-144	presenilin 1	Homo sapiens	239-251
19708161-1	2009	In this combined bioinformatics, molecular dynamics (MD), and density functional theory study, mechanisms for the hydrolytic cleavage of Val-Ile and Ala-Thr peptide bonds of amyloid precursor protein by the intramembrane aspartyl protease presenilin 1 (PS1) have been elucidated.	Isoleucine	141-144	presenilin 1	Homo sapiens	253-256
19946423-5	2009	It was noted that an isoleucine residue in the ATP binding site of human, rat, and mouse HRI is replaced by a valine in the canine kinase.	Isoleucine	21-31	eukaryotic translation initiation factor 2 alpha kinase 1	Mus musculus	89-92
19347242-2	2009	Tyrosine phosphorylated Glu-Pro-Ile-Tyr-Ala motif in CagA (CagA-P) plays a critical role in the morphological transformation of cells.	Isoleucine	32-35	S100 calcium binding protein A8	Homo sapiens	53-57
19347242-2	2009	Tyrosine phosphorylated Glu-Pro-Ile-Tyr-Ala motif in CagA (CagA-P) plays a critical role in the morphological transformation of cells.	Isoleucine	32-35	S100 calcium binding protein A8	Homo sapiens	59-65
18808456-6	2009	This allowed us to identify a diacidic motif, DIE (Asp-Ile-Glu), at position 4-6 of the N-terminus of ZmPIP2;5, that is essential for ER export.	Isoleucine	55-58	aquaporin PIP2-5	Zea mays	102-110
18991400-9	2008	Alanine mutations of Lys(484), Leu(552), Asp(591), Ile(602), Lys(616), Asp(620), and Pro(621) compromised affinities for insulin 2-5-fold.	Isoleucine	51-54	insulin	Homo sapiens	121-128
19050258-2	2008	In BALB/c mice, DFL16.1 RF2 encodes valine and isoleucine.	Isoleucine	47-57	retroperitoneal fat pad weight 2	Mus musculus	24-27
19038921-5	2008	Additionally, no N-glycosylation was found in the recombinant human alpha-LA, whereas the endogenous bovine alpha-LA was glycosylated at the unusual site (71)Asn-Ile-(73)Cys.	Isoleucine	162-165	lactalbumin alpha	Homo sapiens	108-116
19254477-2	2009	DULP contains a domain that shares 26% identity and 34% similarity with ubiquitin, and it possesses the corresponding Ile-44 hydrophobic patch used by mono- or poly-ubiquitin to interact with a ubiquitin-interaction motif (UIM) or ubiquitin-associated domain (UBA).	Isoleucine	118-121	transmembrane and ubiquitin like domain containing 1	Homo sapiens	0-4
19036977-1	2008	RNA editing that converts adenosine to inosine replaces the gene-encoded Ile, Asn, and Ile (INI) of serotonin [5-hydroxytryptamine (5-HT)] receptor 2C (5-HT(2C)R) with Val, Gly, and Val (VGV).	Isoleucine	73-76	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	152-161
18767117-2	2008	Leu, Ile, and Val increased S6K1 phosphorylation compared to that measured in AA-deprived cells.	Isoleucine	5-8	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	28-32
18955862-7	2008	RESULTS: We identified a novel mutation in ITGB4, with homozygous deletion of a single residue (isoleucine 1314) within the intracellular plectin-binding domain.	Isoleucine	96-106	integrin subunit beta 4	Homo sapiens	43-48
18927106-3	2008	These alleles were chosen because they show the highest activity in suppression of ionizing radiation sensitivity of the rad57 mutant, and Val 328 and Ile 345 are conserved in the human Rad51 protein.	Isoleucine	151-154	RAD51 recombinase	Homo sapiens	186-191
18708347-7	2008	NMR heteronuclear single quantum coherence titrations revealed that upon binding, both molecules significantly perturb EphA4 residues Ile(31)-Met(32) in the D-E loop, Gln(43) in the E beta-strand, and Ile(131)-Gly(132) in the J-K loop.	Isoleucine	134-137	EPH receptor A4	Homo sapiens	119-124
18682385-5	2008	In contrast, leucine, alpha-ketoisovalerate, valine, and isoleucine neither inhibited nor were transported by Oac1p.	Isoleucine	57-67	Oac1p	Saccharomyces cerevisiae S288C	110-115
18855981-2	2008	METHODS: We constructed recombinant adenovirus vector expressing a mutant type p27(kip1) gene (ad-p27mt), with mutation of Thr-187/Pro-188 (ACGCCC) to Met-187/Ile-188 (ATGATC), and transduced into SW480 cells.	Isoleucine	159-162	cyclin dependent kinase inhibitor 1B	Homo sapiens	79-88
18616983-3	2008	In the present study, we examined the direct effect of 5 mM amino acids (leucine, isoleucine, valine, glutamine and arginine) on atrogin-1 and MuRF1 levels in C2C12 muscle cells and the involved intracellular signal transduction pathway.	Isoleucine	82-92	F-box protein 32	Mus musculus	129-138
18616983-7	2008	The inhibitory effect of leucine, isoleucine or arginine on atrogin-1 mRNA level was reversed by rapamycin, although wortmannin did not reverse the effect.	Isoleucine	34-44	F-box protein 32	Mus musculus	60-69
18616983-9	2008	The inhibitory effect of leucine, isoleucine or arginine on MuRF1 mRNA levels was not reversed by rapamycin.	Isoleucine	34-44	tripartite motif-containing 63	Mus musculus	60-65
18616983-10	2008	Taken together, these findings indicated that leucine, isoleucine and arginine decreased atrogin-1 mRNA levels via mTOR and that different pathways were involved in the effect of those amino acids on MuRF1 mRNA levels.	Isoleucine	55-65	F-box protein 32	Mus musculus	89-98
18616983-10	2008	Taken together, these findings indicated that leucine, isoleucine and arginine decreased atrogin-1 mRNA levels via mTOR and that different pathways were involved in the effect of those amino acids on MuRF1 mRNA levels.	Isoleucine	55-65	mechanistic target of rapamycin kinase	Mus musculus	115-119
18616983-10	2008	Taken together, these findings indicated that leucine, isoleucine and arginine decreased atrogin-1 mRNA levels via mTOR and that different pathways were involved in the effect of those amino acids on MuRF1 mRNA levels.	Isoleucine	55-65	tripartite motif-containing 63	Mus musculus	200-205
18621735-6	2008	Alanine at this position restored Na+ binding affinity, whereas substitution with larger neutral amino acids (threonine, valine, and isoleucine) abolished hCNT3 H+-dependent nucleoside transport activity.	Isoleucine	133-143	solute carrier family 28 member 3	Homo sapiens	155-160
18521819-5	2008	The presence of valine alleles compared to isoleucine alleles in codon 105 in GSTP1 did not increase the risk of breast cancer development.	Isoleucine	43-53	glutathione S-transferase pi 1	Homo sapiens	78-83
18562515-5	2008	Mutations introduced into two residues (Ile(176) and Phe(177)) upstream of the cleavage site of the core protein abrogated processing by SPP and localization in the DRM fraction.	Isoleucine	40-43	histocompatibility minor 13	Homo sapiens	137-140
18539702-4	2008	First, the absence of efficacy for PTHrP at PTH-2R is due to the presence of His-5 in PTHrP (Ile-5 in PTH), which interacts with the receptor"s juxtamembrane domain.	Isoleucine	93-96	parathyroid hormone like hormone	Homo sapiens	86-91
18539702-6	2008	We used these different receptor subtype properties to demonstrate that residue 41 in PTH-1R, when either the native Leu or substituted by Ile or Met, can accommodate either Phe or Trp at position 23 of the ligand.	Isoleucine	139-142	parathyroid hormone 1 receptor	Homo sapiens	86-92
18463259-5	2008	Through characterizing rTRPA1 and hTRPA1 chimeric channels and point mutations, we identified several residues in the upper portion of the S6 transmembrane domains as critical determinants of the opposite channel gating: Ala-946 and Met-949 of rTRPA1 determine channel activation, whereas equivalent residues of hTRPA1 (Ser-943 and Ile-946) determine channel block.	Isoleucine	332-335	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	23-29
18698233-2	2008	Two relatively common variants of the TLR4 gene are present, resulting in changes from aspartic acid (D) to glycine (G) at residue 299 and from threonine (T) to isoleucine (I) at residue 399, respectively.	Isoleucine	161-171	toll like receptor 4	Homo sapiens	38-42
18550521-4	2008	Among others, Trp-2, which is the key residue forming the canonical strand-exchange dimer, is replaced by an isoleucine.	Isoleucine	109-119	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	14-19
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	105-115	glutathione S-transferase pi 1	Homo sapiens	4-9
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	105-115	glutathione S-transferase pi 1	Homo sapiens	186-191
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	117-120	glutathione S-transferase pi 1	Homo sapiens	4-9
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Isoleucine	117-120	glutathione S-transferase pi 1	Homo sapiens	186-191
18570467-7	2008	However, the rupture of the Gly( P 1) approximately Ile( P 1") amide bond is destabilized in the static QM/MM calculations, owing to the positioning of the Ile( P 1") side chain inside the MMP-2 S 1" pocket and to the inability of simple energy miminization methodologies to properly relax complex systems.	Isoleucine	52-55	matrix metallopeptidase 2	Homo sapiens	189-194
18570467-7	2008	However, the rupture of the Gly( P 1) approximately Ile( P 1") amide bond is destabilized in the static QM/MM calculations, owing to the positioning of the Ile( P 1") side chain inside the MMP-2 S 1" pocket and to the inability of simple energy miminization methodologies to properly relax complex systems.	Isoleucine	156-159	matrix metallopeptidase 2	Homo sapiens	189-194
18441012-3	2008	The crystal structure of FXI demonstrates formation of salt bridges between Lys-331 of one subunit and Glu-287 of the other subunit and hydrophobic interactions at the interface of the Apple 4 domains involving Ile-290, Leu-284, and Tyr-329.	Isoleucine	211-214	coagulation factor XI	Homo sapiens	25-28
18465874-8	2008	The presence in PfFKBD of Cys-106 and Ser-109 (substituting for His-87 and Ile-90, respectively, in human FKBP12), which are 4-5 A from the nearest atom of the FK506 compound, suggests possible routes for the rational design of analogues of FK506 with specific antiparasitic activity.	Isoleucine	75-78	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	106-112
18708347-7	2008	NMR heteronuclear single quantum coherence titrations revealed that upon binding, both molecules significantly perturb EphA4 residues Ile(31)-Met(32) in the D-E loop, Gln(43) in the E beta-strand, and Ile(131)-Gly(132) in the J-K loop.	Isoleucine	201-204	EPH receptor A4	Homo sapiens	119-124
18721280-1	2008	A new HLA-B*4085 showed one nucleotide difference from B*400201 at the position 500 of exon 3, resulting in a coding change from Thr to Ile (T143I).	Isoleucine	136-139	major histocompatibility complex, class I, B	Homo sapiens	6-11
17687647-1	2008	A polymorphism at codon 655 (ATC/isoleucine to GTC/valine [Ile655Val], rs1801200) in the transmembrane domain-coding region of human ERBB2 gene has been previously evaluated for its association with breast cancer risk with mixed results.	Isoleucine	33-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-138
18422648-11	2008	The interest derives from the observation that an individual with this Ile mutated to Asn, in the KH2 domain of fragile X mental retardation protein, exhibits a particularly severe form of the syndrome.	Isoleucine	71-74	fragile X messenger ribonucleoprotein 1	Homo sapiens	112-148
18461142-2	2008	We previously identified a transmembrane domain polymorphism, TLR1_T1805G, that encodes an isoleucine to serine substitution and is associated with impaired signaling.	Isoleucine	91-101	toll like receptor 1	Homo sapiens	62-66
18463259-5	2008	Through characterizing rTRPA1 and hTRPA1 chimeric channels and point mutations, we identified several residues in the upper portion of the S6 transmembrane domains as critical determinants of the opposite channel gating: Ala-946 and Met-949 of rTRPA1 determine channel activation, whereas equivalent residues of hTRPA1 (Ser-943 and Ile-946) determine channel block.	Isoleucine	332-335	transient receptor potential cation channel subfamily A member 1	Homo sapiens	34-40
18384376-6	2008	Mutational analysis of 4E-BP1 reveals that isoleucine is a key feature of the RAIP motif, that proline is also very important and that there is greater tolerance for substitution of the first two residues.	Isoleucine	43-53	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	23-29
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Isoleucine	153-156	acetylcholinesterase	Mus musculus	6-10
18216108-5	2008	Mutational analyses of NS5A revealed that a single amino acid residue of Val or Ile at position 121, which is well conserved among all genotypes of HCV, is critical for the specific interaction with FKBP8.	Isoleucine	80-83	FKBP prolyl isomerase 8	Homo sapiens	199-204
18558604-11	2008	Analysis of the patient"s DNA revealed a heterozygous T-to-C substitution at amino acid 568 in exon 10 (Ile568Thr), which predicts an isoleucine to threonine conversion in the second extracellular loop of TSHR.	Isoleucine	134-144	thyroid stimulating hormone receptor	Homo sapiens	205-209
18071882-7	2008	RESULTS: The frequency of isoleucine at TAP2 379 (34.5%) was increased among DHF in comparison to controls (21%, P = 0.014).	Isoleucine	26-36	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	40-44
18315550-7	2008	The crystal structure of thrombin in complex with FM19 shows that the N-terminal D-Arg retrobinds into the S1 pocket, its second residue Oic interacts with His-57, Tyr-60a and Trp-60d, and its C-terminal p-methyl Phe engages thrombin"s aryl binding site composed of Ile-174, Trp-215, and Leu-99.	Isoleucine	266-269	coagulation factor II	Mus musculus	25-33
18247047-3	2008	JAR1 encodes an enzyme that conjugates jasmonic acid (JA) to isoleucine, which was recently shown to function directly in CORONATINE INSENSITIVE 1 (COI1)-mediated signal transduction.	Isoleucine	61-71	Auxin-responsive GH3 family protein	Arabidopsis thaliana	0-4
18247047-3	2008	JAR1 encodes an enzyme that conjugates jasmonic acid (JA) to isoleucine, which was recently shown to function directly in CORONATINE INSENSITIVE 1 (COI1)-mediated signal transduction.	Isoleucine	61-71	RNI-like superfamily protein	Arabidopsis thaliana	122-146
18247047-3	2008	JAR1 encodes an enzyme that conjugates jasmonic acid (JA) to isoleucine, which was recently shown to function directly in CORONATINE INSENSITIVE 1 (COI1)-mediated signal transduction.	Isoleucine	61-71	RNI-like superfamily protein	Arabidopsis thaliana	148-152
18247047-6	2008	Kinetic analysis showed that JAR1 had a K (m) of 0.03 mM for Ile, which was 60-80-fold lower than for Leu, Val and Phe.	Isoleucine	61-64	Auxin-responsive GH3 family protein	Arabidopsis thaliana	29-33
18281275-10	2008	This, in turn, facilitates an intermediate thioether bond between Cys-143 and Ile-142, the site of AC cleavage.	Isoleucine	78-81	N-acylsphingosine amidohydrolase 1	Homo sapiens	99-101
18294953-6	2008	Notably, Ile is the residue found in the guinea pig AhR, towards which MNF has partial agonist activity in contrast to its strong antagonist activity in mouse.	Isoleucine	9-12	aryl hydrocarbon receptor	Cavia porcellus	52-55
18391214-6	2008	The results confirm that the inhibitor selectivity of MAOA and MAOB is caused by the structural differences arising from Ile-335 in MAOA vs. Tyr-326 in MAOB.	Isoleucine	121-124	monoamine oxidase A	Homo sapiens	54-58
18391214-6	2008	The results confirm that the inhibitor selectivity of MAOA and MAOB is caused by the structural differences arising from Ile-335 in MAOA vs. Tyr-326 in MAOB.	Isoleucine	121-124	monoamine oxidase B	Homo sapiens	63-67
18391214-6	2008	The results confirm that the inhibitor selectivity of MAOA and MAOB is caused by the structural differences arising from Ile-335 in MAOA vs. Tyr-326 in MAOB.	Isoleucine	121-124	monoamine oxidase A	Homo sapiens	132-136
18391214-6	2008	The results confirm that the inhibitor selectivity of MAOA and MAOB is caused by the structural differences arising from Ile-335 in MAOA vs. Tyr-326 in MAOB.	Isoleucine	121-124	monoamine oxidase B	Homo sapiens	152-156
18268008-4	2008	Isoleucine, the amino acid in mutant Sum1-1p, was required for the novel spreading property.	Isoleucine	0-10	Sum1p	Saccharomyces cerevisiae S288C	37-41
18268008-6	2008	The presence of isoleucine caused Sum1-1p to self-associate, a property that may promote spreading.	Isoleucine	16-26	Sum1p	Saccharomyces cerevisiae S288C	34-38
18268008-8	2008	Thus, both threonine and isoleucine at position 988 enable Sum1p to form intermolecular interactions.	Isoleucine	25-35	Sum1p	Saccharomyces cerevisiae S288C	59-64
18393239-6	2008	The mutation is a 9 base pair(bp) deletion in exon 5 (c.483del9) that results in a putative PAX6 protein with in-frame deletions of aspartic acid, isoleucine and serine at the amino acids 41-43.	Isoleucine	147-157	paired box 6	Homo sapiens	92-96
18193418-4	2008	Among mutant Ilv5p enzymes with varying degrees of N-terminal truncation, one with a 46-residue deletion (Ilv5pDelta46) exhibited an unequivocal localization in the cytosol judged from microscopy of the Ilv5pDelta46-green fluorescent protein fusion protein and the inability of Ilv5pDelta46 to remedy the isoleucine/valine requirement of an ilv5Delta strain.	Isoleucine	305-315	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	13-18
18193418-4	2008	Among mutant Ilv5p enzymes with varying degrees of N-terminal truncation, one with a 46-residue deletion (Ilv5pDelta46) exhibited an unequivocal localization in the cytosol judged from microscopy of the Ilv5pDelta46-green fluorescent protein fusion protein and the inability of Ilv5pDelta46 to remedy the isoleucine/valine requirement of an ilv5Delta strain.	Isoleucine	305-315	ketol-acid reductoisomerase	Saccharomyces cerevisiae S288C	106-118
18245370-6	2008	The polymorphism occurs in codon 648, resulting in a nonconservative change from threonine to isoleucine, suggesting that the allele may affect enamelin function.	Isoleucine	94-104	enamelin	Homo sapiens	144-152
18160180-4	2008	Kinetic studies revealed that Ile-Phe (Km: 3.1 mM, P(app): 2.4 x 10(-6) cm/s) exhibited greater affinity toward the transport compared with Ala-Phe (K(m): 48.1 mM, P(app): 1.4 x 10(-6) cm/s) and Phe-Ile (K(m): 12.7 mM, P(app): 1.4 x 10(-6) cm/s).	Isoleucine	30-33	X-prolyl aminopeptidase 2	Homo sapiens	51-60
18160180-4	2008	Kinetic studies revealed that Ile-Phe (Km: 3.1 mM, P(app): 2.4 x 10(-6) cm/s) exhibited greater affinity toward the transport compared with Ala-Phe (K(m): 48.1 mM, P(app): 1.4 x 10(-6) cm/s) and Phe-Ile (K(m): 12.7 mM, P(app): 1.4 x 10(-6) cm/s).	Isoleucine	30-33	X-prolyl aminopeptidase 1	Homo sapiens	164-173
18160180-4	2008	Kinetic studies revealed that Ile-Phe (Km: 3.1 mM, P(app): 2.4 x 10(-6) cm/s) exhibited greater affinity toward the transport compared with Ala-Phe (K(m): 48.1 mM, P(app): 1.4 x 10(-6) cm/s) and Phe-Ile (K(m): 12.7 mM, P(app): 1.4 x 10(-6) cm/s).	Isoleucine	30-33	X-prolyl aminopeptidase 1	Homo sapiens	219-228
18234503-1	2008	Plants and microorganisms synthesize valine, leucine and isoleucine via a common pathway in which the first reaction is catalysed by acetohydroxyacid synthase (AHAS, EC 2.2.1.6).	Isoleucine	57-67	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	133-158
18234503-1	2008	Plants and microorganisms synthesize valine, leucine and isoleucine via a common pathway in which the first reaction is catalysed by acetohydroxyacid synthase (AHAS, EC 2.2.1.6).	Isoleucine	57-67	chlorsulfuron/imidazolinone resistant 1	Arabidopsis thaliana	160-164
18339256-6	2008	The rate of the CYP1A1 isoleucine (Ile)/valine (Val) allele was significantly higher in patients with PCOS than in the controls (OR: 7.8, 95% CI: 3.45-17.52, P &lt; 0.001).	Isoleucine	23-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-22
18339256-6	2008	The rate of the CYP1A1 isoleucine (Ile)/valine (Val) allele was significantly higher in patients with PCOS than in the controls (OR: 7.8, 95% CI: 3.45-17.52, P &lt; 0.001).	Isoleucine	35-38	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-22
18174155-5	2008	Single amino acid substitutions of Ile-719 and Glu-749 in the beta3 membrane-proximal and -distal regions, respectively, with the corresponding beta1 residues or alanine rendered alphaIIbbeta3 constitutively active.	Isoleucine	35-38	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	62-67
18174155-5	2008	Single amino acid substitutions of Ile-719 and Glu-749 in the beta3 membrane-proximal and -distal regions, respectively, with the corresponding beta1 residues or alanine rendered alphaIIbbeta3 constitutively active.	Isoleucine	35-38	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	144-149
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Isoleucine	30-40	glutathione S-transferase pi 1	Homo sapiens	18-23
17709273-5	2008	Residues Y(413)ILDD(417) and D(423)IDE(426) are crucial for binding to thrombin; the two critical amino acids for thrombin binding, Ile(414) and Ile(424), are brought into spatial proximity by beta-sheet structure.	Isoleucine	132-135	coagulation factor II, thrombin	Homo sapiens	71-79
17709273-5	2008	Residues Y(413)ILDD(417) and D(423)IDE(426) are crucial for binding to thrombin; the two critical amino acids for thrombin binding, Ile(414) and Ile(424), are brought into spatial proximity by beta-sheet structure.	Isoleucine	145-148	coagulation factor II, thrombin	Homo sapiens	71-79
17872377-7	2008	Divergent residue 5 in the ligand, Ile in PTH and His in PTHrP, was identified as a key determinant of the altered receptor-interaction responses exhibited by the two peptides.	Isoleucine	35-38	parathyroid hormone	Homo sapiens	42-45
17872377-7	2008	Divergent residue 5 in the ligand, Ile in PTH and His in PTHrP, was identified as a key determinant of the altered receptor-interaction responses exhibited by the two peptides.	Isoleucine	35-38	parathyroid hormone like hormone	Homo sapiens	57-62
17986713-1	2008	The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) in a Chinese population.	Isoleucine	181-191	lipase G, endothelial type	Homo sapiens	64-82
17986713-1	2008	The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) in a Chinese population.	Isoleucine	181-191	lipase G, endothelial type	Homo sapiens	84-86
17986713-1	2008	The aim of the present study was to assess the influence of the endothelial lipase (EL) gene 584C/T variant, which results in a change at codon 111 of the EL gene from threonine to isoleucine, on the risk of coronary artery disease (CAD) in a Chinese population.	Isoleucine	181-191	lipase G, endothelial type	Homo sapiens	155-157
17651379-3	2008	Molecular analysis showed homozygous intron 7 (+1) g &gt; a in the CD18 gene, resulting in three splicing transcriptions that inserted 64, 298 (5" end of intron 7), and 1157 (whole intron 7) nucleotides into the 300th amino acid of Ile and stopped at the 326th (inserted 64 and 1157 nucleotides) and the 344th (inserted 64 nucleotides), respectively.	Isoleucine	232-235	integrin subunit beta 2	Homo sapiens	67-71
18068724-5	2008	In agreement with previous mutagenesis analyses, the Fab" interacts primarily with V3 through side-chain contacts with just two residues, Ile(P309) and Arg(P315), while the remaining contacts are to the main chain.	Isoleucine	138-141	FA complementation group B	Homo sapiens	53-56
18154359-2	2008	The human HNMT gene contains a common threonine-isoleucine polymorphism at residue 105, distal from the active site.	Isoleucine	48-58	histamine N-methyltransferase	Homo sapiens	10-14
17676332-3	2008	RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship.	Isoleucine	41-51	glutathione S-transferase pi 1	Homo sapiens	18-23
17676332-4	2008	GSTP1 (105) isoleucine/isoleucine was found to be associated with lower levels of S-IgG-MDI and fewer eye symptoms, but with an increased risk of symptoms in the airways, as well as with atopy.	Isoleucine	12-22	glutathione S-transferase pi 1	Homo sapiens	0-5
18682704-7	2008	Multivariate analysis revealed that declines in glycerol and leucine/isoleucine (markers of lipolysis and proteolysis, respectively) jointly provide the strongest predictor of insulin sensitivity.	Isoleucine	69-79	insulin	Homo sapiens	176-183
18574320-3	2008	The presence of isoleucine at position 264 in CYP2C8 was found to be important for proper haem insertion and protein folding; whereas bulkier or charged residues were highly disruptive resulting in inactive proteins with minimum spectral and catalytic activities.	Isoleucine	16-26	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	46-52
17945527-1	2008	2-Methylbutyryl-CoA dehydrogenase (MBD; coded by the ACADSB gene) catalyzes the step in isoleucine metabolism that corresponds to the isovaleryl-CoA dehydrogenase reaction in the degradation of leucine.	Isoleucine	88-98	acyl-CoA dehydrogenase short/branched chain	Homo sapiens	53-59
17945527-1	2008	2-Methylbutyryl-CoA dehydrogenase (MBD; coded by the ACADSB gene) catalyzes the step in isoleucine metabolism that corresponds to the isovaleryl-CoA dehydrogenase reaction in the degradation of leucine.	Isoleucine	88-98	isovaleryl-CoA dehydrogenase	Homo sapiens	134-162
17854853-5	2007	Kinetics studies showed that ABU-LAO is very active towards its substrates L-Asn, L-Phe, L-Tyr, L-Leu, L-Ile and L-Trp.	Isoleucine	103-108	interleukin 4 induced 1	Homo sapiens	33-36
17967520-4	2007	The mutation is a single T to A base substitution in exon 10 of Otof that causes a non-conservative amino acid change of isoleucine to asparagine in the C2B domain of the protein.	Isoleucine	121-131	otoferlin	Mus musculus	64-68
18008022-0	2007	Amino acids that confer transport of raffinose and maltose sugars in the raffinose permease (RafB) of Escherichia coli as implicated by spontaneous mutations at Val-35, Ser-138, Ser-139, Gly-389 and Ile-391.	Isoleucine	199-202	hypothetical protein	Escherichia coli	93-97
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Isoleucine	41-44	glutathione S-transferase pi 1	Homo sapiens	9-14
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Isoleucine	45-48	glutathione S-transferase pi 1	Homo sapiens	9-14
18067083-10	2007	In the third family, the sequencing of the CYP21 gene of two patients revealed a homozygous T to A transition in codon 172 leading to substitution of isoleucine by asparagine (I172N).	Isoleucine	150-160	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	43-48
17761678-11	2007	PMP70(AA.263-375) also possesses hydrophobic residues (Ile(307)/Leu(308)) in the region adjacent to TMD5, which were important for targeting.	Isoleucine	55-58	ATP binding cassette subfamily D member 3	Homo sapiens	0-5
20641675-11	2004	A synthetic peptide (Arg-Glu-Asn-Leu-Arg-Ile-Ala-Leu-Arg-Tyr, B2702-p) corresponding to residues 75-84 of HLA-B2702 was shown to bind specifically to VCAM-1 (9).	Isoleucine	41-44	major histocompatibility complex, class I, B	Homo sapiens	106-111
18225649-5	2007	According to the data on hydrogen exchange in the native RNase A molecule, the dynamic stability of the tertiary structure of domain II is lower than that of domain I because of the lesser amount of the internal bulky nonpolar residues Val, Ile, and Phe.	Isoleucine	241-244	ribonuclease A family member 1, pancreatic	Homo sapiens	57-64
17726027-6	2007	Morphological FRET was utilized to demonstrate that secretin receptor oligomerization occurred at the cell surface and that this oligomerization was disrupted by mutating Gly(243) and Ile(247), key residues within the lipid-exposed face of TM IV.	Isoleucine	184-187	secretin receptor	Homo sapiens	52-69
17883254-3	2007	The inhibition of H 2O 2-induced IL-8 secretion from Caco-2 cells was observed by pretreatment with Cys, Val, Ile, Leu, Trp, His, Lys, and Ala.	Isoleucine	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
17890402-6	2007	Time-of-flight secondary ion mass spectrometry showed that relative intensities of both sulfur-containing (cystine, methionine) and hydrophobic (glycine, leucine/isoleucine) amino acids varied with changing Fn surface coverage, indicating that the conformation of adsorbed Fn depended on surface coverage.	Isoleucine	162-172	fibronectin 1	Homo sapiens	207-209
20641641-17	2004	A peptide, GGPRQITAG, was found to be a MMP-2/9 substrate from a phage library and is cleaved between Gln (Q) and Ile (I) residues (14).	Isoleucine	114-117	matrix metallopeptidase 2	Homo sapiens	40-47
20641641-21	2004	The NIR fluorescence signal will increase when the Gln-Ile bond is cleaved by MMP-2/9, releasing fragments that contain Cy5.5.	Isoleucine	55-58	matrix metallopeptidase 2	Homo sapiens	78-85
17286976-5	2007	Triple mutation of mammalian V1aR (Phe(6.51) to Tyr, Ile(6.53) to Thr, and Pro(7.33) to Thr) increases VT affinity but greatly reduces arginine vasopressin affinity.	Isoleucine	53-56	arginine vasopressin receptor 1A	Homo sapiens	29-33
17641029-2	2007	Recently, the KIR3DS1 allele has been shown to slow progression to AIDS in individuals expressing HLA-Bw4 with isoleucine at position 80.	Isoleucine	111-121	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	Homo sapiens	14-21
17522200-8	2007	Furthermore, Ile-25, Val-26, and Ile-29 of the NS4A protein, important for the NS4A-dependent internal cleavages, were also shown to be critical for the transforming activity of NS3, but mutations at these critical residues resulted only in a slight increase of HCV replicating efficiency.	Isoleucine	13-16	KRAS proto-oncogene, GTPase	Homo sapiens	178-181
17522200-8	2007	Furthermore, Ile-25, Val-26, and Ile-29 of the NS4A protein, important for the NS4A-dependent internal cleavages, were also shown to be critical for the transforming activity of NS3, but mutations at these critical residues resulted only in a slight increase of HCV replicating efficiency.	Isoleucine	33-36	KRAS proto-oncogene, GTPase	Homo sapiens	178-181
17640901-6	2007	Overall, state change seems to occur by attachment of a hydrophobic triplet (Trp-546, Phe-547, and Pro-548) of myosin to an actin conduit with a hydrophobic guiding rail (Ile-341, Ile-345, Leu-349, and Phe-352) and the subsequent linear movement of the triplet along the rail.	Isoleucine	171-174	myosin heavy chain 14	Homo sapiens	111-117
17640901-6	2007	Overall, state change seems to occur by attachment of a hydrophobic triplet (Trp-546, Phe-547, and Pro-548) of myosin to an actin conduit with a hydrophobic guiding rail (Ile-341, Ile-345, Leu-349, and Phe-352) and the subsequent linear movement of the triplet along the rail.	Isoleucine	180-183	myosin heavy chain 14	Homo sapiens	111-117
19636815-0	2007	Backbone and sidechain methyl Ile (delta1), Leu and Val resonance assignments of the catalytic domain of the yeast mRNA decapping enzyme, Dcp2.	Isoleucine	30-33	decapping enzyme, scavenger	Mus musculus	115-136
19636815-0	2007	Backbone and sidechain methyl Ile (delta1), Leu and Val resonance assignments of the catalytic domain of the yeast mRNA decapping enzyme, Dcp2.	Isoleucine	30-33	decapping enzyme complex catalytic subunit	Saccharomyces cerevisiae S288C	138-142
17937921-2	2007	Crystal structures of an FFRP, DM1 from Pyrococcus, were determined in complex with isoleucine, which increases the association state of DM1 to form octamers, and with selenomethionine, which decreases it to maintain dimers under some conditions.	Isoleucine	84-94	DM1 protein kinase	Homo sapiens	31-34
17937921-2	2007	Crystal structures of an FFRP, DM1 from Pyrococcus, were determined in complex with isoleucine, which increases the association state of DM1 to form octamers, and with selenomethionine, which decreases it to maintain dimers under some conditions.	Isoleucine	84-94	DM1 protein kinase	Homo sapiens	137-140
17767554-2	2007	Compared with HLA-B*530101, there is one silent substitution at nucleotide 438 and two non-synonymous substitutions at nucleotides 431 and 440, causing a change of the amino acid sequence (Asn--&gt;Ser at codon 77 and Ile--&gt;Thr at codon 80, respectively) within the Bw4 epitope.	Isoleucine	218-221	major histocompatibility complex, class I, B	Homo sapiens	14-19
17804707-6	2007	The cocrystal structure of T315I Abl kinase domain provides the structural basis for this activity: the inhibitor associates with an active conformation of the kinase domain in the ATP-binding pocket and lacks the steric hindrance imposed by the substitution of threonine by isoleucine.	Isoleucine	275-285	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	33-36
17618155-0	2007	HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids.	Isoleucine	70-80	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	0-8
17618155-2	2007	This gene encodes HSD10, a mitochondrial multifunctional enzyme that plays a significant part in the metabolism of neuroactive steroids and the degradation of isoleucine.	Isoleucine	159-169	fibrous sheath interacting protein 1	Homo sapiens	18-23
17893655-9	2007	The first is a 9 base pair (bp) deletion in exon 5 (c.483del9) that makes a PAX6 protein with de novo in-frame deletions of aspartic acid, isoleucine, and serine at the amino acid codon positions 41-43.	Isoleucine	139-149	paired box 6	Homo sapiens	76-80