PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7499841-4	1995	However, when combined with a multivalent membrane (m)Ig-mediated cross-linking signal, dextran-conjugated anti-IgD Abs (alpha delta-dex), lipoproteins mediate up to 10,000-fold inductions in IgM secretion and up to 25-fold enhancements in cellular proliferation relative to that observed with alpha delta-dex alone, in the absence of added cytokines.	alpha delta-dex	121-136	chemokine (C-X-C motif) ligand 9	Mus musculus	54-56
10967029-3	2000	Here we show that IL-4 can have both stimulatory and inhibitory effects on alpha delta-dex-induced Ig secretion.	alpha delta-dex	75-90	interleukin 4	Homo sapiens	18-22
10967029-5	2000	Preincubation of sort-purified B cells with IL-4 caused a 6- to 8-fold increase in Ig secretory responses to subsequent stimulation with alpha delta-dex plus IL-1, IL-2 or a combination of both.	alpha delta-dex	137-152	interleukin 4	Homo sapiens	44-48
9973462-5	1999	Whereas, previously reported, B cells lacking p50 alone had a severe proliferative defect in response to LPS, a moderate defect in response to CD40 ligand (CD40L), and normal proliferation to Ag receptor cross-linking using dextran-conjugated anti-IgD Abs (alpha delta-dex), B cells lacking both p50 and p65 exhibited severely impaired proliferation in response to LPS, alpha delta-dex, and CD40L.	alpha delta-dex	257-272	nuclear factor kappa B subunit 1	Homo sapiens	46-49
9973462-5	1999	Whereas, previously reported, B cells lacking p50 alone had a severe proliferative defect in response to LPS, a moderate defect in response to CD40 ligand (CD40L), and normal proliferation to Ag receptor cross-linking using dextran-conjugated anti-IgD Abs (alpha delta-dex), B cells lacking both p50 and p65 exhibited severely impaired proliferation in response to LPS, alpha delta-dex, and CD40L.	alpha delta-dex	370-385	nuclear factor kappa B subunit 1	Homo sapiens	46-49
8598461-2	1996	p50-/- B cells proliferated normally in response to dextran-anti-IgD Abs (alpha delta-dex) and membrane-bound, but not soluble, CD40 ligand (CD40), and they were virtually unresponsive to LPS when compared with control B cells.	alpha delta-dex	74-89	CD40 antigen	Mus musculus	0-3
8598461-3	1996	p50-/- B cells secreted markedly reduced Ig in response to alpha delta-dex or mCD40L in the presence of IL-4 + IL-5, despite their relatively normal proliferative rates, whereas normal Ig secretion was restored by the combination of alpha delta-dex and CD40L.	alpha delta-dex	59-74	CD40 antigen	Mus musculus	0-3
8598461-3	1996	p50-/- B cells secreted markedly reduced Ig in response to alpha delta-dex or mCD40L in the presence of IL-4 + IL-5, despite their relatively normal proliferative rates, whereas normal Ig secretion was restored by the combination of alpha delta-dex and CD40L.	alpha delta-dex	59-74	interleukin 4	Mus musculus	104-108
8598461-3	1996	p50-/- B cells secreted markedly reduced Ig in response to alpha delta-dex or mCD40L in the presence of IL-4 + IL-5, despite their relatively normal proliferative rates, whereas normal Ig secretion was restored by the combination of alpha delta-dex and CD40L.	alpha delta-dex	233-248	CD40 antigen	Mus musculus	0-3
7499841-4	1995	However, when combined with a multivalent membrane (m)Ig-mediated cross-linking signal, dextran-conjugated anti-IgD Abs (alpha delta-dex), lipoproteins mediate up to 10,000-fold inductions in IgM secretion and up to 25-fold enhancements in cellular proliferation relative to that observed with alpha delta-dex alone, in the absence of added cytokines.	alpha delta-dex	294-309	chemokine (C-X-C motif) ligand 9	Mus musculus	54-56
7529796-6	1995	Furthermore, alpha delta-dex inhibited the LPS induction of both gamma 3 and gamma 2b germ-line RNA and the associated secretion of IgG3 and IgG2b.	alpha delta-dex	13-28	immunoglobulin heavy constant gamma 2B	Mus musculus	65-85
7538533-4	1995	The enhancing effects of IL-3 and GM-CSF require multivalent Ag receptor cross-linkage, mediated by alpha delta-dex, as neither cytokine induces IgM secretion in the presence of unconjugated anti-IgD Abs.	alpha delta-dex	100-115	interleukin 3	Mus musculus	25-29
7538533-4	1995	The enhancing effects of IL-3 and GM-CSF require multivalent Ag receptor cross-linkage, mediated by alpha delta-dex, as neither cytokine induces IgM secretion in the presence of unconjugated anti-IgD Abs.	alpha delta-dex	100-115	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	34-40
7538533-5	1995	Although both alpha delta-dex and IL-1 + IL-2 are required for optimal IL-3- and GM-CSF-mediated IgM secretion, both IL-3 and GM-CSF stimulate a modest IgM secretory response by cells activated with alpha delta-dex alone.	alpha delta-dex	14-29	interleukin 3	Mus musculus	71-75
7538533-5	1995	Although both alpha delta-dex and IL-1 + IL-2 are required for optimal IL-3- and GM-CSF-mediated IgM secretion, both IL-3 and GM-CSF stimulate a modest IgM secretory response by cells activated with alpha delta-dex alone.	alpha delta-dex	14-29	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	81-87
7529796-6	1995	Furthermore, alpha delta-dex inhibited the LPS induction of both gamma 3 and gamma 2b germ-line RNA and the associated secretion of IgG3 and IgG2b.	alpha delta-dex	13-28	Immunoglobulin heavy constant gamma 3	Mus musculus	132-136
7529796-6	1995	Furthermore, alpha delta-dex inhibited the LPS induction of both gamma 3 and gamma 2b germ-line RNA and the associated secretion of IgG3 and IgG2b.	alpha delta-dex	13-28	immunoglobulin heavy constant gamma 2B	Mus musculus	141-146
7529796-7	1995	A similar alpha delta-dex-mediated suppression of germ-line gamma 2a RNA and IgG2a secretion in LPS + IFN-gamma-stimulated cultures was observed.	alpha delta-dex	10-25	immunoglobulin heavy variable V1-9	Mus musculus	77-82
7529796-7	1995	A similar alpha delta-dex-mediated suppression of germ-line gamma 2a RNA and IgG2a secretion in LPS + IFN-gamma-stimulated cultures was observed.	alpha delta-dex	10-25	interferon gamma	Mus musculus	102-111
8228222-1	1993	We previously demonstrated that dextran-conjugated anti-IgD antibodies (alpha delta-dex) induce proliferation of small, B cell-enriched murine spleen cells (Be cells), and in the presence of IL-2, stimulate Ig secretion in vitro.	alpha delta-dex	72-87	interleukin 2	Mus musculus	191-195
7529792-5	1995	In contrast, concentrations as low as 3 pg/ml of multivalent, dextran-conjugated, anti-IgD (alpha delta-dex) or anti-IgM (alpha mu-dex) were strongly synergistic with CD40L for induction of B cell proliferation, viable cell outgrowth, Ig isotype switching, and maturation to Ig secretion.	alpha delta-dex	92-107	CD40 ligand	Mus musculus	167-172
7529792-8	1995	Surprisingly, although we previously demonstrated that alpha delta-dex selectively and strongly suppressed IgE production by T cell-activated B cells, it strikingly augmented IgE expression by CD40L-activated B cells.	alpha delta-dex	55-70	CD40 ligand	Mus musculus	193-198
1714474-1	1991	Cross-linkage of membrane IgD on resting murine B cells, by anti-IgD mAb conjugated to dextran (alpha delta-dex), induces high levels of proliferation, and in the presence of IL-2 or IL-5, Ig secretion in vitro.	alpha delta-dex	96-111	interleukin 2	Mus musculus	175-179
7680684-9	1993	By contrast, alpha delta-dex augmented IgM and IgG1 secretion by resting B cells stimulated with either an anti-CD3-activated CD4+ Th2 clone or with activated T cell membranes in combination with IL-4 + IL-5.	alpha delta-dex	13-28	LOC105243590	Mus musculus	47-51
7680684-9	1993	By contrast, alpha delta-dex augmented IgM and IgG1 secretion by resting B cells stimulated with either an anti-CD3-activated CD4+ Th2 clone or with activated T cell membranes in combination with IL-4 + IL-5.	alpha delta-dex	13-28	interleukin 4	Mus musculus	196-200
7680684-9	1993	By contrast, alpha delta-dex augmented IgM and IgG1 secretion by resting B cells stimulated with either an anti-CD3-activated CD4+ Th2 clone or with activated T cell membranes in combination with IL-4 + IL-5.	alpha delta-dex	13-28	interleukin 5	Mus musculus	203-207
1714474-1	1991	Cross-linkage of membrane IgD on resting murine B cells, by anti-IgD mAb conjugated to dextran (alpha delta-dex), induces high levels of proliferation, and in the presence of IL-2 or IL-5, Ig secretion in vitro.	alpha delta-dex	96-111	interleukin 5	Mus musculus	183-187
1714474-6	1991	Alpha delta-dex is selective in its failure to costimulate IgE production in that IFN-gamma-containing T cell supernatant (Th1 SN) and transforming growth factor-beta-supplemented Th2 SN selectively stimulate a large IgG2a and IgA secretory response, respectively.	alpha delta-dex	0-15	interferon gamma	Mus musculus	82-91
1714474-6	1991	Alpha delta-dex is selective in its failure to costimulate IgE production in that IFN-gamma-containing T cell supernatant (Th1 SN) and transforming growth factor-beta-supplemented Th2 SN selectively stimulate a large IgG2a and IgA secretory response, respectively.	alpha delta-dex	0-15	immunoglobulin heavy variable V1-9	Mus musculus	217-222