PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34019385-3 2021 A quantitative analysis of the SARS-CoV-2 lysate was performed by monitoring the change in the SERS peak intensity caused by the new binding between the aptamer DNA released from the Au nanopopcorn surface and the spike protein in the SARS-CoV-2 virion. sers 95-99 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 214-219 6537850-5 1984 SERs revealed a delay in the first negative peak after P14 in the tuberothalamic patients, and a delay in the third negative peak (N60) in all patients. sers 0-4 ribonuclease P/MRP subunit p14 Homo sapiens 55-58 34015600-3 2021 Au@Ag NPs, as an ultrasensitive SERS substrate, show the dual activities (peroxidase-like and GOx-like activities). sers 32-36 hydroxyacid oxidase 1 Homo sapiens 94-97 33607489-5 2021 When modified with aptamers of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR), which are both expressed in MCF-7 and MDA-MB-231 cell lines but in different levels, the SERS nanoprobes simultaneously identified the relative expression of these biomarkers on the cell surface, providing a good example for ratiometric detection in biosystems without any interference. sers 207-211 epithelial cell adhesion molecule Homo sapiens 31-64 34029872-3 2021 Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1. sers 21-25 angiotensin converting enzyme 2 Homo sapiens 70-101 34029872-3 2021 Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1. sers 21-25 angiotensin converting enzyme 2 Homo sapiens 103-107 34029872-3 2021 Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1. sers 21-25 angiotensin converting enzyme 2 Homo sapiens 145-149 34029872-3 2021 Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1. sers 129-133 angiotensin converting enzyme 2 Homo sapiens 70-101 34029872-3 2021 Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1. sers 129-133 angiotensin converting enzyme 2 Homo sapiens 103-107 34029872-3 2021 Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1. sers 129-133 angiotensin converting enzyme 2 Homo sapiens 145-149 34029872-4 2021 The recognition and binding of receptor binding domain (RBD) of SARS-CoV-2 spike protein on SERS assay significantly quenched the spectral intensities of most peaks and exhibited a shift from 1189 to 1182 cm-1. sers 92-96 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 75-80 33607489-5 2021 When modified with aptamers of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR), which are both expressed in MCF-7 and MDA-MB-231 cell lines but in different levels, the SERS nanoprobes simultaneously identified the relative expression of these biomarkers on the cell surface, providing a good example for ratiometric detection in biosystems without any interference. sers 207-211 epithelial cell adhesion molecule Homo sapiens 66-71 33607489-5 2021 When modified with aptamers of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR), which are both expressed in MCF-7 and MDA-MB-231 cell lines but in different levels, the SERS nanoprobes simultaneously identified the relative expression of these biomarkers on the cell surface, providing a good example for ratiometric detection in biosystems without any interference. sers 207-211 epidermal growth factor receptor Homo sapiens 77-109 33607489-5 2021 When modified with aptamers of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR), which are both expressed in MCF-7 and MDA-MB-231 cell lines but in different levels, the SERS nanoprobes simultaneously identified the relative expression of these biomarkers on the cell surface, providing a good example for ratiometric detection in biosystems without any interference. sers 207-211 epidermal growth factor receptor Homo sapiens 111-115 32311837-0 2021 A SERS Quenching Method for the Sensitive Determination of Insulin. sers 2-6 insulin Homo sapiens 59-66 32311837-1 2021 In this work, we utilise the disulfide bond structure of insulin and a new benzothiazole Raman probe for the detection of human insulin by surface enhanced Raman spectroscopy (SERS). sers 176-180 insulin Homo sapiens 57-64 32311837-1 2021 In this work, we utilise the disulfide bond structure of insulin and a new benzothiazole Raman probe for the detection of human insulin by surface enhanced Raman spectroscopy (SERS). sers 176-180 insulin Homo sapiens 128-135 32311837-4 2021 Using this approach, insulin was quantified in the concentration range 1x10-14 to 1x10-8 M by SERS quenching. sers 94-98 insulin Homo sapiens 21-28 32311837-5 2021 The limit of quantification (LOQ) of insulin by the SERS quenching method was found to be 1x10-14 M (0.01 pM or 58 pg/L), which satisfies the requirements for monitoring its blood concentration in patients. sers 52-56 insulin Homo sapiens 37-44 33591724-7 2021 The protocol owns the merits of the SERS technology, amplified reciprocal signals, and a microfluidic chip, with a detection limit of 2.92 fM for miR-141 in 40 min. sers 36-40 microRNA 141 Homo sapiens 146-153 33534593-6 2021 The pH-associated reversibility of the SERS spectrum of PATP is established as an observation of the DMAB dimer at high pH and of PATP as a product of its hot-electron reduction at low pH, in the presence of the appropriate ligand. sers 39-43 alcohol dehydrogenase iron containing 1 Homo sapiens 155-158 33660989-0 2021 Promoted "Click" SERS Detection for Precise Intracellular Imaging of Caspase-3. sers 17-21 caspase 3 Homo sapiens 69-78 33660989-8 2021 Moreover, we found that the SERS intensity was positively related with caspase-3 concentration, which has a wide linear range (0.1 ng/mL to 10 mug/mL) and low detection limit (7.18 x 10-2 ng/mL). sers 28-32 caspase 3 Homo sapiens 71-80 33660989-9 2021 Remarkably, these simultaneously enlarged signals by "Click" SERS could be used for more precise imaging of caspase-3, providing mutually confirmed logical judgment based on two spliced SERS emissions, especially for their relative intensity. sers 61-65 caspase 3 Homo sapiens 108-117 33660989-9 2021 Remarkably, these simultaneously enlarged signals by "Click" SERS could be used for more precise imaging of caspase-3, providing mutually confirmed logical judgment based on two spliced SERS emissions, especially for their relative intensity. sers 186-190 caspase 3 Homo sapiens 108-117 33791276-3 2021 CDFeN strongly catalyzes the oxidation of 3,3",5,5"-tetramethylbenzidine (TMB) by H2O2 to turn on an indicator molecular reaction, forming an oxidized tetramethylbenzidine (TMBox) probe with surface-enhanced Raman scattering, resonance Rayleigh scattering, and fluorescence (SERS, RRS, and FL) signals at 1,598 cm-1, 370 nm, and 405 nm, respectively. sers 275-279 fms related receptor tyrosine kinase 3 ligand Homo sapiens 290-292 33791276-4 2021 The urea aptamer (Apt) can turn off the indicator reaction to reduce the tri-signals, and the addition of urea turns on the indicator reaction to linearly enhance the SERS/RRS/FL intensity. sers 167-171 fms related receptor tyrosine kinase 3 ligand Homo sapiens 176-178 33221138-1 2021 In this study, we proposed a novel method for the determination of nanomolar dissolved sulfides, including H2S, HS-, and S2- (defined as S(-II)) in water by coupling the classical methylene blue (MB) method with surface-enhanced Raman spectroscopy (SERS) detection. sers 249-253 transcription elongation factor A1 Homo sapiens 137-143 33583183-6 2021 A secondary antibody linked to an SERS-encoded nanoparticle was employed as the Raman signal reporter, that is, the transducer for AFP detection. sers 34-38 alpha fetoprotein Homo sapiens 131-134 33136303-3 2021 These SERS spectra were then used to generate two concentration calibration models (via a plot of peak area (1026 cm-1 ) versus concentration, and quantitative spectral decomposition using partial least squares (PLS1)). sers 6-10 plastin 1 Homo sapiens 212-216 33508938-3 2021 Herein, we rationally designed a type of Cu2+-activated nanoprobe based on nanogapped gold nanoparticles (AuNNP) and poly(N-isopropylacrylamide) (PNIPAM) to simultaneously quantify the liver Cu2+ content and urinary Cu2+ in WD by photoacoustic (PA) imaging and ratiometric surface-enhanced Raman scattering (SERS), respectively. sers 308-312 immunoglobulin kappa variable 1-35 Mus musculus 41-44 33508938-8 2021 Both NIR-II PA1250 nm and SERS I2223/I1378 signals of the nanoprobe show a linear relationship with the concentration of Cu2+. sers 26-30 immunoglobulin kappa variable 1-35 Mus musculus 121-124 33508938-9 2021 The nanoprobe was successfully applied for in vivo quantitative detection of liver Cu2+ of WD mice through NIR-II PA imaging and accurate quantification of urinary Cu2+ of WD patients by ratiometric SERS. sers 199-203 immunoglobulin kappa variable 1-35 Mus musculus 83-86 33048457-0 2021 SERS-based sensor for direct L-selectin level determination in plasma samples as alternative method of tumour detection. sers 0-4 selectin L Homo sapiens 29-39 33578775-7 2021 The sample obtained at 600 C exhibited 50 times higher substrate enhancement factor (SEF) than the one obtained at 400 C, suggesting that the calcination temperature was a determining parameter to enhance SERS activity in current synthetic condition. sers 207-211 transcription factor CP2 Homo sapiens 56-84 33578775-7 2021 The sample obtained at 600 C exhibited 50 times higher substrate enhancement factor (SEF) than the one obtained at 400 C, suggesting that the calcination temperature was a determining parameter to enhance SERS activity in current synthetic condition. sers 207-211 transcription factor CP2 Homo sapiens 86-89 33319869-0 2021 A portable SERS reader coupled with catalytic hairpin assembly for sensitive microRNA-21 lateral flow sensing. sers 11-15 microRNA 21 Homo sapiens 77-88 33283805-3 2021 In the presence of caspase-3, the substrate peptides can be cleaved and the changed surface charge of the Au nanoboxes results in the Au nanoboxes-NBA-peptide assembling to form aggregates and a great enhancement of SERS signal. sers 216-220 caspase 3 Homo sapiens 19-28 33283805-5 2021 The SERS probes exhibited excellent reproducibility and selectivity toward caspase-3. sers 4-8 caspase 3 Homo sapiens 75-84 33283805-9 2021 Upon cellular uptake of these probes, the spatiotemporal dynamics of caspase-3 in apoptotic cells could be real-time monitored using SERS. sers 133-137 caspase 3 Homo sapiens 69-78 33048457-3 2021 We demonstrate the surface enhanced Raman spectroscopy (SERS)-based sensor for the determination of L-selectin level in biological samples that can be used in medical diagnosis. sers 56-60 selectin L Homo sapiens 100-110 33403256-6 2020 At the SPR angle, the SERS signal of the symmetric configuration was 60 times higher than that of the conventional SPR configuration. sers 22-26 sepiapterin reductase Homo sapiens 7-10 33356556-3 2021 Aim: Identify the TNF-alpha in an aqueous solution, using gold nanoparticles (AuNPs) as a SERS substrate. sers 90-94 tumor necrosis factor Homo sapiens 18-27 33356556-9 2021 Conclusion: TNF-alpha signal at physiological concentrations was determined with SERS. sers 81-85 tumor necrosis factor Homo sapiens 12-21 33284591-7 2020 Using this SERS sensor array, multiple cancer-associated miRNAs (miR-1246, miR-221, miR-133a, and miR-21) were successfully determined in buffer, serum, and cellular RNA extracts. sers 11-15 microRNA 1246 Homo sapiens 65-73 33284591-7 2020 Using this SERS sensor array, multiple cancer-associated miRNAs (miR-1246, miR-221, miR-133a, and miR-21) were successfully determined in buffer, serum, and cellular RNA extracts. sers 11-15 microRNA 221 Homo sapiens 75-82 33284591-7 2020 Using this SERS sensor array, multiple cancer-associated miRNAs (miR-1246, miR-221, miR-133a, and miR-21) were successfully determined in buffer, serum, and cellular RNA extracts. sers 11-15 microRNA 21 Homo sapiens 98-104 33403256-6 2020 At the SPR angle, the SERS signal of the symmetric configuration was 60 times higher than that of the conventional SPR configuration. sers 22-26 sepiapterin reductase Homo sapiens 115-118 33165490-0 2020 SERS-based magnetic immunoassay for simultaneous detection of cTnI and H-FABP using core-shell nanotags. sers 0-4 troponin I3, cardiac type Homo sapiens 62-66 33165490-0 2020 SERS-based magnetic immunoassay for simultaneous detection of cTnI and H-FABP using core-shell nanotags. sers 0-4 fatty acid binding protein 3 Homo sapiens 71-77 33161976-8 2020 We anticipate this SERS-based immunoassay method to be applied to TYR detection in the clinical setting and to be extended to other promising related fields. sers 19-23 tyrosinase Homo sapiens 66-69 33190692-0 2020 A novel sandwich-type SERS immunosensor for selective and sensitive carcinoembryonic antigen (CEA) detection. sers 22-26 CEA cell adhesion molecule 3 Homo sapiens 68-92 33190692-0 2020 A novel sandwich-type SERS immunosensor for selective and sensitive carcinoembryonic antigen (CEA) detection. sers 22-26 CEA cell adhesion molecule 3 Homo sapiens 94-97 32866724-5 2020 The relative standard deviation values of the SERS intensity of the eight-channel for measuring the AFP, CEA, and PSA antigens at 1323 cm-1 were 13%, 4.8%, and 5%, respectively. sers 46-50 alpha fetoprotein Homo sapiens 100-103 33103897-0 2020 Click-Reaction-Triggered SERS Signals for Specific Detection of Monoamine Oxidase B Activity. sers 25-29 monoamine oxidase B Homo sapiens 64-83 33103897-3 2020 In this work, a novel surface-enhanced Raman scattering (SERS) sensor was fabricated and the MAOB activity was specifically determined by detecting the SERS signals of an enzyme-catalyzed reaction product via an amine-aldehyde click reaction. sers 57-61 monoamine oxidase B Homo sapiens 93-97 33103897-3 2020 In this work, a novel surface-enhanced Raman scattering (SERS) sensor was fabricated and the MAOB activity was specifically determined by detecting the SERS signals of an enzyme-catalyzed reaction product via an amine-aldehyde click reaction. sers 152-156 monoamine oxidase B Homo sapiens 93-97 32866724-5 2020 The relative standard deviation values of the SERS intensity of the eight-channel for measuring the AFP, CEA, and PSA antigens at 1323 cm-1 were 13%, 4.8%, and 5%, respectively. sers 46-50 CEA cell adhesion molecule 3 Homo sapiens 105-108 33161972-0 2020 Anti-fouling SERS-based immunosensor for point-of-care detection of the B7-H6 tumor biomarker in cervical cancer patient serum. sers 13-17 natural killer cell cytotoxicity receptor 3 ligand 1 Homo sapiens 72-77 33161972-2 2020 Anti-fouling capture SERS substrate of biosensor based on gold (Au) thin film was modified with a self-assembled monolayer of zwitterionic l-cysteine to combat serum fouling and was then conjugated with NKp30 receptor protein to capture the B7-H6 biomarker in blood serum. sers 21-25 natural killer cell cytotoxicity receptor 3 ligand 1 Homo sapiens 241-246 33161972-4 2020 Then, it was conjugated with anti-B7-H6 antibody forming the complex anti-B7-H6@ATP@AuNPs (i.e., SERS nanoprobe). sers 97-101 natural killer cell cytotoxicity receptor 3 ligand 1 Homo sapiens 34-39 33161972-4 2020 Then, it was conjugated with anti-B7-H6 antibody forming the complex anti-B7-H6@ATP@AuNPs (i.e., SERS nanoprobe). sers 97-101 natural killer cell cytotoxicity receptor 3 ligand 1 Homo sapiens 74-79 33161976-0 2020 Interference-free SERS tags for ultrasensitive quantitative detection of tyrosinase in human serum based on magnetic bead separation. sers 18-22 tyrosinase Homo sapiens 73-83 33161976-4 2020 Our results demonstrated that under magnetic separation, the specific SERS signal obtained is highly correlated with TYR concentrations. sers 70-74 tyrosinase Homo sapiens 117-120 33408980-3 2020 The SERS-supporting substrates based on hydrophobic filter paper were composed of gold nanourchins (GNUs) surface-functionalized with the Cyt c aptamer and the cyanine 5-labeled complementary DNA. sers 4-8 cytochrome c, somatic Homo sapiens 138-143 33408980-4 2020 In the existence of Cyt c, it could specifically bind to its aptamer, which leads to the detachment of complementary strands modified with Cy5 and the great weakness of SERS signal. sers 169-173 cytochrome c, somatic Homo sapiens 20-25 33408980-11 2020 This method can be a powerful strategy for quantitative detection of extracellular Cyt c, and it is expected that the SERS-based biosensors could be applied in the practical clinical diagnoses of NSCLC. sers 118-122 cytochrome c, somatic Homo sapiens 83-88 32777732-4 2020 By combining asymmetric polymerase chain reaction (PCR) and SERS, a highly-selective detection for EGFR mutation genes in lung cancer was developed. sers 60-64 epidermal growth factor receptor Homo sapiens 99-103 32964253-3 2020 Through optimization of the SERS conditions, including the volume of SA-protected AgNPs solution, pH of Britton-Robinson (BR) buffer solution and concentration of NaCl solution, linear responses were obtained for PTU and MTZ in the concentration ranges of 3.02 x 10-9-1.06 x 10-5 mol L-1 and 1.21 x 10-9-1.21 x 10-5 mol L-1, respectively. sers 28-32 L1 cell adhesion molecule Homo sapiens 284-293 33182636-0 2020 Effect of Varying Expression of EpCAM on the Efficiency of CTCs Detection by SERS-Based Immunomagnetic Optofluidic Device. sers 77-81 epithelial cell adhesion molecule Homo sapiens 32-37 33182636-7 2020 In this work, we have also investigated the effect of varying expression of the EpCAM established by the Western Blot method supported by immunochemistry on the efficiency of CTCs" detection with the developed SERS method. sers 210-214 epithelial cell adhesion molecule Homo sapiens 80-85 33164013-2 2020 Here, we use a non-destructive approach for detecting and localising ERalpha expression at the single cell level using surface enhanced Raman spectroscopy (SERS) combined with functionalised gold nanoparticles (AuNPs). sers 156-160 estrogen receptor 1 Homo sapiens 69-76 33164013-4 2020 Additionally, we developed an approach based on the percentage area of SERS response to qualitatively measure expression level in ERalpha positive (ERalpha+) breast cancer cells. sers 71-75 estrogen receptor 1 Homo sapiens 130-137 33164013-4 2020 Additionally, we developed an approach based on the percentage area of SERS response to qualitatively measure expression level in ERalpha positive (ERalpha+) breast cancer cells. sers 71-75 estrogen receptor 1 Homo sapiens 148-155 33164013-5 2020 Specifically, the calculation of relative SERS response demonstrated that MCF-7 cells (ERalpha+) exhibited higher nanotag accumulation resulting in a 4.2-times increase in SERS signal area in comparison to SKBR-3 cells (ERalpha-). sers 42-46 estrogen receptor 1 Homo sapiens 87-94 33164013-5 2020 Specifically, the calculation of relative SERS response demonstrated that MCF-7 cells (ERalpha+) exhibited higher nanotag accumulation resulting in a 4.2-times increase in SERS signal area in comparison to SKBR-3 cells (ERalpha-). sers 172-176 estrogen receptor 1 Homo sapiens 87-94 33164013-8 2020 SERS mapping confirmed that ERalpha degradation occurred after fulvestrant treatment since a weaker SERS signal, and hence accumulation of nanotags, was observed in MCF-7 cells treated with fulvestrant. sers 0-4 estrogen receptor 1 Homo sapiens 28-35 33164013-8 2020 SERS mapping confirmed that ERalpha degradation occurred after fulvestrant treatment since a weaker SERS signal, and hence accumulation of nanotags, was observed in MCF-7 cells treated with fulvestrant. sers 100-104 estrogen receptor 1 Homo sapiens 28-35 33164013-9 2020 Most importantly, a correlation coefficient of 0.9 between the SERS response and the ERalpha expression level, obtained by western blot, was calculated. sers 63-67 estrogen receptor 1 Homo sapiens 85-92 33164013-10 2020 These results confirmed the strong relationship between the two approaches and open up the possibilities of using SERS as a tool for the estimation of ERalpha expression levels, without the requirement of destructive and time-consuming techniques. sers 114-118 estrogen receptor 1 Homo sapiens 151-158 32960046-6 2020 Subsequently, the characteristic SERS signal of the RNA hybridization event was obtained by studying the process of RNA hairpin structure formation, and the role of the precursor mir-21 in regulating the target streptomycin sulfate was successfully analyzed. sers 33-37 microRNA 21 Homo sapiens 179-185 32951348-6 2020 The SERS spectra were analyzed using principal component analysis (PCA), which showed that ALS-1, ALS-2, ALS-3, and control groups were separated significantly. sers 4-8 superoxide dismutase 1 Homo sapiens 91-96 32951348-6 2020 The SERS spectra were analyzed using principal component analysis (PCA), which showed that ALS-1, ALS-2, ALS-3, and control groups were separated significantly. sers 4-8 alsin Rho guanine nucleotide exchange factor ALS2 Homo sapiens 98-103 32951348-6 2020 The SERS spectra were analyzed using principal component analysis (PCA), which showed that ALS-1, ALS-2, ALS-3, and control groups were separated significantly. sers 4-8 ALS3 Homo sapiens 105-110 32344338-6 2020 Therefore an ultralow detection limit of 0.40 pg mL-1 in a wide linear range of 0.0001-100 ng mL-1 was obtained and the sensibility of this SERS aptasensor was higher than that of the Cy3-Apt based SERS aptasensor. sers 140-144 L1 cell adhesion molecule Mus musculus 49-53 33282484-0 2020 Imaging of PD-L1 in single cancer cells by SERS-based hyperspectral analysis. sers 43-47 CD274 molecule Homo sapiens 11-16 33282484-8 2020 In conclusion, the method of analyzing hyperspectral SERS imaging data together with systematic and comprehensive removal of non-specific signals allows SERS imaging to be a quantitative tool in the detection of the cancer biomarker, PD-L1. sers 53-57 CD274 molecule Homo sapiens 234-239 33282484-8 2020 In conclusion, the method of analyzing hyperspectral SERS imaging data together with systematic and comprehensive removal of non-specific signals allows SERS imaging to be a quantitative tool in the detection of the cancer biomarker, PD-L1. sers 153-157 CD274 molecule Homo sapiens 234-239 32790343-3 2020 Here, in-situ surface-enhanced Raman spectroscopy (SERS) empowered by 13C/12C isotope exchange is applied to probing the CO2ER process on nanoporous silver (np-Ag). sers 51-55 complement C2 Homo sapiens 121-126 32344338-6 2020 Therefore an ultralow detection limit of 0.40 pg mL-1 in a wide linear range of 0.0001-100 ng mL-1 was obtained and the sensibility of this SERS aptasensor was higher than that of the Cy3-Apt based SERS aptasensor. sers 140-144 L1 cell adhesion molecule Mus musculus 94-98 32344338-6 2020 Therefore an ultralow detection limit of 0.40 pg mL-1 in a wide linear range of 0.0001-100 ng mL-1 was obtained and the sensibility of this SERS aptasensor was higher than that of the Cy3-Apt based SERS aptasensor. sers 198-202 L1 cell adhesion molecule Mus musculus 49-53 32418325-0 2020 SERS analysis of serum albumin via adsorption-exfoliation on hydroxyapatite nanoparticles for noninvasive cancers screening. sers 0-4 albumin Homo sapiens 23-30 32786384-6 2020 As a result, the limit of detection (LOD) as low as 0.25 fg mL-1 could be achieved, which was lower than other reported literatures on SERS methods for OTA detection as we know. sers 135-139 L1 cell adhesion molecule Mus musculus 60-64 32661529-6 2020 Both of them have sufficient sensitivity (0.05-10 mg L-1), good linear relationship (R2 > 0.99) and high recovery in quantitative SERS analysis. sers 130-134 L1 cell adhesion molecule Homo sapiens 53-56 32361317-3 2020 We first examined the SERS spectra of the primary breast cancer single cell and normal epithelial single cell obtained by flow sorting cytometry due to their biomarkers of CD326+/CD45-. sers 22-26 protein tyrosine phosphatase receptor type C Homo sapiens 179-183 32902446-5 2020 This study demonstrates the potential of SERS spectroscopy for rapidly screening and identifying new anti-Abeta therapeutic agents. sers 41-45 amyloid beta precursor protein Homo sapiens 106-111 32854399-4 2020 More importantly, we used it as a SERS substrate to detect cadmium ions and found that its limit of detection (LOD) reaches up to 2.6 x 10-8 M, which is lower than the highest allowable Cd2+ concentration in drinking water set by the World Health Organization (WHO) and Environmental Protection Agency (EPA). sers 34-38 CD2 molecule Homo sapiens 186-189 32793992-4 2020 For FB1, under 980-nm laser excitation, the logarithmic value of SERS signal intensity at 1567 cm-1 gradually increases with the concentration of FB1 in the range 0.05-200 pg mL-1 (R2 = 0.996). sers 65-69 L1 cell adhesion molecule Mus musculus 175-179 32418325-3 2020 Serum albumin was adsorbed and exfoliated by HAp from serum samples of liver cancer patients, breast cancer patients and healthy volunteers, and mixed with silver colloids to perform SERS spectral analysis. sers 183-187 albumin Homo sapiens 0-13 32685826-5 2020 Notably, we have shown that mixed-dimensional heterostructure-based SERS can be used for tracking of cancer-derived exosomes from triple-negative breast cancer and HER2(+) breast cancer with a limit of detection (LOD) of 3.8 x 102 exosomes/mL for TNBC-derived exosomes and 4.4 x 102 exosomes/mL for HER2(+) breast cancer-derived exosomes. sers 68-72 erb-b2 receptor tyrosine kinase 2 Homo sapiens 164-168 32767890-6 2020 RESULTS: Average SERS spectra from Ctr, MCI, and AD subjects evidenced differences related to lactoferrin and lysozyme protein components. sers 17-21 lysozyme Homo sapiens 110-118 32436503-2 2020 Herein, we demonstrate the direct detection of the esophageal cancer biomarker, miR-21, in RNA extracted from 17 endoscopic tissue biopsies using the nanophotonics technology our group has developed, termed the inverse molecular sentinel (iMS) nanobiosensor, with surface-enhanced Raman scattering (SERS) detection. sers 299-303 microRNA 21 Homo sapiens 80-86 32250516-3 2020 Here, we trap a gold nanoparticle in a plasmonic nanohole to generate a single SERS hot spot for single-molecule detection of 2 alike polypeptides (vasopressin and oxytocin) and 10 distinct amino acids that constitute the 2 polypeptides. sers 79-83 arginine vasopressin Homo sapiens 148-159 32251895-2 2020 According to the simulated results by COMSOL Multiphysics, the microfluidic-SERS sensor was fabricated by simultaneously introducing into 40 mmol L-1 silver nitrate solution and 0.2 mol L-1 sodium nitrate solution for about 15 min with the flow velocity at 20 mL min-1 at room temperature, respectively. sers 76-80 CD59 molecule (CD59 blood group) Homo sapiens 263-268 32380829-6 2020 It is demonstrated that the plasmonic resonance wavelength (PRW) stemmed from the 3D plasmonic coupling is correlated with the SERS averaged surface enhancement factor (ASEF), and which is improved by over 10-fold at the optimum 3D nanostructure. sers 127-131 Rho guanine nucleotide exchange factor 4 Homo sapiens 169-173 32380829-9 2020 We expect that the tuning of plasmonic coupling at 3D level can open up new routes to design high performance SERS substrates for wide applications. sers 110-114 serpin family C member 1 Homo sapiens 48-53 32685826-5 2020 Notably, we have shown that mixed-dimensional heterostructure-based SERS can be used for tracking of cancer-derived exosomes from triple-negative breast cancer and HER2(+) breast cancer with a limit of detection (LOD) of 3.8 x 102 exosomes/mL for TNBC-derived exosomes and 4.4 x 102 exosomes/mL for HER2(+) breast cancer-derived exosomes. sers 68-72 erb-b2 receptor tyrosine kinase 2 Homo sapiens 299-303 32411663-8 2020 By choosing 4-aminothiophenol and bovine serum albumin (BSA) as a model analyte, we establish an ultrasensitive assay for label-free SERS detection. sers 133-137 albumin Homo sapiens 41-54 33017959-0 2020 Optimal Scree-CNN for Detecting NS1 Molecular Fingerprint from Salivary SERS Spectra. sers 72-76 influenza virus NS1A binding protein Homo sapiens 32-35 33017959-5 2020 SERS is an enhanced variant of Raman spectroscopy, with extremely high amplification that enables spectra of low concentration matter, such as NS1 in saliva, readable. sers 0-4 influenza virus NS1A binding protein Homo sapiens 143-146 33017959-8 2020 This paper aims to unravel an optimal Scree-CNN model for classification of salivary NS1 SERS spectra. sers 89-93 influenza virus NS1A binding protein Homo sapiens 85-88 32533266-5 2020 Based on this principle, the developed SERS method exhibited good linearity in the range 0 to 1 nM for miRNA-21 with a limit of detection (LOD) of 0.084 fM and has an ability to differentiate even a single-base mismatched sequence on the target sequence or other miRNA sequence. sers 39-43 microRNA 21 Homo sapiens 103-111 32533266-6 2020 The results provide a novel SERS method which can successfully been applied to the miRNA-21 detection in human serum. sers 28-32 microRNA 21 Homo sapiens 83-91 33005736-5 2020 The peptide-conjugated GNS-SERS barcodes were leveraged to achieve high sensitivity, with a limit of detection (LOD) of 0.0055 ng/ml of cTnI, and a LOD of 0.12 ng/ml of NPY comparable with commercially available test kits. sers 27-31 troponin I3, cardiac type Homo sapiens 136-140 33005736-5 2020 The peptide-conjugated GNS-SERS barcodes were leveraged to achieve high sensitivity, with a limit of detection (LOD) of 0.0055 ng/ml of cTnI, and a LOD of 0.12 ng/ml of NPY comparable with commercially available test kits. sers 27-31 neuropeptide Y Homo sapiens 169-172 32397331-0 2020 Patterned Superhydrophobic SERS Substrates for Sample Pre-Concentration and Demonstration of Its Utility through Monitoring of Inhibitory Effects of Paraoxon and Carbaryl on AChE. sers 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 32397331-7 2020 We demonstrate the utility of the patterned SERS substrate by evaluating the effects of inhibitors to acetylcholinesterase (AChE). sers 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 32397331-7 2020 We demonstrate the utility of the patterned SERS substrate by evaluating the effects of inhibitors to acetylcholinesterase (AChE). sers 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 32397331-9 2020 We monitored the enzymatic activity of AChE through the SERS spectrum of thiocholine (TC), the end product from acetylthiocholine (ATC). sers 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 32125287-6 2020 Alk-S-Cit was visualized in the coronal mouse brain section using SERS imaging with silver nanoparticles. sers 66-70 anaplastic lymphoma kinase Mus musculus 0-3 32207951-6 2020 Exploiting the CGSS, we successfully measured the SERS spectra of Alzheimer"s biomarkers, tau protein and amyloid beta, based on which secondary structural changes were analyzed quantitatively. sers 50-54 microtubule associated protein tau Homo sapiens 90-93 32227892-0 2020 Label-Free SERS Strategy for In Situ Monitoring and Real-Time Imaging of Abeta Aggregation Process in Live Neurons and Brain Tissues. sers 11-15 amyloid beta precursor protein Homo sapiens 73-78 32227892-4 2020 Different gold nanoparticles, generated in situ with Abeta monomer and fibril as templates separately, were served as effective SERS substrates to achieve a high sensitivity with a limit of detection (LOD) down to 70 +- 4 pM and 3.0 +- 0.5 pM for Abeta40 monomer and fibrils, respectively. sers 128-132 amyloid beta precursor protein Homo sapiens 53-58 32125287-7 2020 Further, SERS imaging combined with fluorescence microscopy allowed Alk-S-Cit to be visualized in the adjacent neuronal membranes, and in the brain vessel and parenchyma. sers 9-13 anaplastic lymphoma kinase Mus musculus 68-71 32235706-6 2020 The SERS readout was directly proportional to the PKA activity in a wide range of 0.0001-0.5 U muL-1 with a detection limit as low as 0.00003 U muL-1. sers 4-8 mitochondrial E3 ubiquitin protein ligase 1 Homo sapiens 95-100 32235706-6 2020 The SERS readout was directly proportional to the PKA activity in a wide range of 0.0001-0.5 U muL-1 with a detection limit as low as 0.00003 U muL-1. sers 4-8 mitochondrial E3 ubiquitin protein ligase 1 Homo sapiens 144-149 31927237-1 2020 A novel surface enhanced-Raman spectroscopy (SERS) assay for marbofloxacin was developed based on beta-cyclodextrin-modified silver nanoparticles (beta-CD-AgNPs). sers 45-49 adrenocortical dysplasia homolog Gallus gallus 147-154 32188036-1 2020 A novel recyclable surface-enhanced Raman scattering (SERS)-based immunoassay was demonstrated and exhibited extremely high sensitivity toward prostate specific antigen (PSA). sers 54-58 kallikrein related peptidase 3 Homo sapiens 143-168 32188036-1 2020 A novel recyclable surface-enhanced Raman scattering (SERS)-based immunoassay was demonstrated and exhibited extremely high sensitivity toward prostate specific antigen (PSA). sers 54-58 kallikrein related peptidase 3 Homo sapiens 170-173 32188036-5 2020 Subsequently, the recyclable feasibility of PSA detection was approved by zeta potential measurement, absorption spectra, and SEM images and, particularly, more than 80% of SERS intensity still existed after even six cycles of immunoassay. sers 173-177 kallikrein related peptidase 3 Homo sapiens 44-47 32123956-9 2020 We also carried out Surface Enhanced Raman Scattering (SERS) measurements of hIAPP as an experimental validation of both the theory and in silico simulations. sers 55-59 islet amyloid polypeptide Homo sapiens 77-82 31868606-6 2020 Intracellular biothiols show higher affinity to mercury ions than the SERS tags do, which can break the hot spot geometry and redisperse tags by taking away mercury ions from nano-aggregates, which dramatically decreases the SERS signals of reporters previously laid on gold nanoparticles. sers 70-74 alcohol dehydrogenase iron containing 1 Homo sapiens 104-107 31868606-6 2020 Intracellular biothiols show higher affinity to mercury ions than the SERS tags do, which can break the hot spot geometry and redisperse tags by taking away mercury ions from nano-aggregates, which dramatically decreases the SERS signals of reporters previously laid on gold nanoparticles. sers 225-229 alcohol dehydrogenase iron containing 1 Homo sapiens 104-107 32011615-7 2020 As attested by fluorescence images and SERS measurements, the biosensors successfully exhibited enhanced Abeta affinity compared to the bare sensors without ligands. sers 39-43 amyloid beta precursor protein Homo sapiens 105-110 31492295-4 2020 Highly enhanced electromagnetic fields localized around neighboring AuNPs provide hot-spot construction due to the spatial distribution of SERS enhancement on the CA125 proteins at nM concentration level. sers 139-143 mucin 16, cell surface associated Homo sapiens 163-168 31492295-5 2020 Time resolved SERS mapping of CA125 antibody and antigen couples was recorded. sers 14-18 mucin 16, cell surface associated Homo sapiens 30-35 31492295-6 2020 Even though blinking behavior was observed for some cases, vast variety SERS signals from CA125 proteins were highly reproducible. sers 72-76 mucin 16, cell surface associated Homo sapiens 90-95 31492295-8 2020 Distinguished feature of SERS mapping images of CA125 antibody and antigen with such a low concentration level is very promising for this technique to be used for diagnostic purposes. sers 25-29 mucin 16, cell surface associated Homo sapiens 48-53 31874025-6 2020 We demonstrate SERS-based detection of cortisol in the physiologically relevant range using colloidal silver nanoparticles in ethanolic solutions and bovine serum albumin. sers 15-19 albumin Homo sapiens 157-170 32040773-1 2020 An indirect aptamer-based SERS assay for insulin-like growth factor 2 receptor (IGF-IIR) protein was developed. sers 26-30 insulin like growth factor 2 receptor Homo sapiens 41-78 31614254-7 2019 For a sensitive SERS detection, the MIP film was first incubated in sample containing CEA and next incubated in SERS tag. sers 16-20 CEA cell adhesion molecule 3 Homo sapiens 86-89 31535599-3 2020 The new approach for label-free SERS detection of proteins is demonstrated for human insulin. sers 32-36 insulin Homo sapiens 85-92 31535599-9 2020 Using this approach, label-free and reproducible SERS detection of insulin, down to 10 zM (relative standard deviation [RSD] = 5.52%), was achieved. sers 49-53 insulin Homo sapiens 67-74 31678828-2 2020 In this paper, a novel calibration-free SERS-based muPAD with multi-reaction zones for simultaneous quantitative detection of multiple cardiac biomarkers - GPBB, CK-MB and cTnT for early diagnosis and prognosis of acute myocardial infarction (AMI) are presented. sers 40-44 glycogen phosphorylase B Homo sapiens 156-160 31678828-2 2020 In this paper, a novel calibration-free SERS-based muPAD with multi-reaction zones for simultaneous quantitative detection of multiple cardiac biomarkers - GPBB, CK-MB and cTnT for early diagnosis and prognosis of acute myocardial infarction (AMI) are presented. sers 40-44 troponin T2, cardiac type Homo sapiens 172-176 31678828-8 2020 Under an optimised condition, the LOD of our SERS-based muPAD was identified at 8, 10, and 1 pg mL-1, for GPBB, CK-MB and cTnT, respectively, which is well below the clinical cutoff values. sers 45-49 L1 cell adhesion molecule Mus musculus 96-100 31678828-8 2020 Under an optimised condition, the LOD of our SERS-based muPAD was identified at 8, 10, and 1 pg mL-1, for GPBB, CK-MB and cTnT, respectively, which is well below the clinical cutoff values. sers 45-49 glycogen phosphorylase B Homo sapiens 106-110 31678828-8 2020 Under an optimised condition, the LOD of our SERS-based muPAD was identified at 8, 10, and 1 pg mL-1, for GPBB, CK-MB and cTnT, respectively, which is well below the clinical cutoff values. sers 45-49 troponin T2, cardiac type Homo sapiens 122-126 31614254-8 2019 For the SERS tag, gold nanostars (AuNSs) were employed as metal support, coupled to 4-aminothiophenol (4-ATP) as Raman reporter and to a natural antibody for CEA as recognition element. sers 8-12 CEA cell adhesion molecule 3 Homo sapiens 158-161 31741056-2 2019 Silver nanoparticles modified with beta-cyclodextrin (CD-S-Ag NPs) were prepared and serve as a sensitive SERS substrate. sers 106-110 CDP-diacylglycerol synthase 1 Homo sapiens 54-58 31741056-3 2019 beta-CD is both a reductant for silver ions and a host molecule that binds the analytes which leads to strong SERS enhancement. sers 110-114 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 0-7 31741056-7 2019 Graphical abstractSchematic representation of a SERS method involving beta-CD-S-Ag nanoparticles for determination of prazosin and losartan via formation of an inclusion complex. sers 48-52 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 70-77 31741056-7 2019 Graphical abstractSchematic representation of a SERS method involving beta-CD-S-Ag nanoparticles for determination of prazosin and losartan via formation of an inclusion complex. sers 48-52 S-antigen visual arrestin Homo sapiens 78-82 31476600-2 2019 Herein, a novel biosensor combing surface-enhanced Raman spectroscopy (SERS) and surface molecularly imprinted polymer (SMIP) technology was developed for quantitative detection of carcinoembryonic antigen (CEA) that is closely related to several common cancers. sers 71-75 CEA cell adhesion molecule 3 Homo sapiens 181-205 31514496-2 2019 Here, we report an ultrasensitive biosensor to detect protein tyrosine kinase-7 (PTK7), an important protein biomarker on the cell surface, by aptamer conformation-cooperated enzyme-assisted surface-enhanced Raman scattering (SERS) (ACCESS) technology. sers 226-230 protein tyrosine kinase 7 (inactive) Homo sapiens 54-79 31514496-2 2019 Here, we report an ultrasensitive biosensor to detect protein tyrosine kinase-7 (PTK7), an important protein biomarker on the cell surface, by aptamer conformation-cooperated enzyme-assisted surface-enhanced Raman scattering (SERS) (ACCESS) technology. sers 226-230 protein tyrosine kinase 7 (inactive) Homo sapiens 81-85 31514496-4 2019 It transduces the specific binding events between the aptamer and PTK7 protein into dramatically improved SERS signals. sers 106-110 protein tyrosine kinase 7 (inactive) Homo sapiens 66-70 31486254-2 2019 Herein, we investigate the structural changes of CL-bound Fe2+ Cyt c and the correlation with Cyt c release through surface-enhanced Raman spectroscopy (SERS) on nickel substrates. sers 153-157 cytochrome c, somatic Homo sapiens 94-99 31062520-7 2019 Relying on this phenomenon, a SERS biosensor is designed to quantify apurinic/apyrimidinic endonuclease 1 (APE1). sers 30-34 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 69-105 31062520-7 2019 Relying on this phenomenon, a SERS biosensor is designed to quantify apurinic/apyrimidinic endonuclease 1 (APE1). sers 30-34 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 107-111 31062520-9 2019 In addition, APE1 in human serum is analyzed by the SERS biosensor and enzyme-linked immunosorbent assay (ELISA). sers 52-56 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 13-17 31454694-2 2019 Herein, an enzyme-free surface-enhanced Raman scattering (SERS) platform was proposed for sensitive and reliable detection of target miRNA-21 using a corrective internal standard (IS)-based ratiometric SERS probe coupled with mismatched catalytic hairpin assembly (CHA) amplification. sers 58-62 microRNA 21 Homo sapiens 133-141 31454694-2 2019 Herein, an enzyme-free surface-enhanced Raman scattering (SERS) platform was proposed for sensitive and reliable detection of target miRNA-21 using a corrective internal standard (IS)-based ratiometric SERS probe coupled with mismatched catalytic hairpin assembly (CHA) amplification. sers 202-206 microRNA 21 Homo sapiens 133-141 31454694-7 2019 Benefiting from outstanding performances of the ratiometric SERS strategy and enzyme-free CHA amplification system, this platform exhibits sensitivity toward miRNA-21 with a limit of detection of 3.5 fM and a broad dynamic range from 10 fM to 100 nM. sers 60-64 microRNA 21 Homo sapiens 158-166 31476600-2 2019 Herein, a novel biosensor combing surface-enhanced Raman spectroscopy (SERS) and surface molecularly imprinted polymer (SMIP) technology was developed for quantitative detection of carcinoembryonic antigen (CEA) that is closely related to several common cancers. sers 71-75 CEA cell adhesion molecule 3 Homo sapiens 207-210 31299628-0 2019 A SERS-based lateral flow assay biosensor for quantitative and ultrasensitive detection of interleukin-6 in unprocessed whole blood. sers 2-6 interleukin 6 Homo sapiens 91-104 31486639-1 2019 A "signal-off" surface-enhanced Raman scattering (SERS) platform has been constructed for ultrasensitive detection of miRNA-21 by integrating exonuclease-assisted target recycling amplification with a plasmon coupling enhancement effect. sers 50-54 microRNA 21 Homo sapiens 118-126 31382096-3 2019 Anti-albumin antibodies were encapsulated on the glass chip and SERS tag through dopamine self-polymerization in alkaline conditions and the immunoaffinity was highly maintained to form the sandwich structure with the addition of target microalbuminuria. sers 64-68 albumin Homo sapiens 5-12 31382096-5 2019 High specificity and selectivity of this SERS method were demonstrated by performing with some common proteins include human hemoglobin protein (Hgb) and human immunoglobulin G (IgG) in urine. sers 41-45 cytoglobin Homo sapiens 145-148 31376711-5 2019 As a result, a large amount of ROX-labeled Raman probes could be anchored on the surface of MBs and used for SERS detection. sers 109-113 MAX network transcriptional repressor Homo sapiens 31-34 31299628-2 2019 A surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) is developed for the quantitative analysis of IL-6. sers 37-41 interleukin 6 Homo sapiens 120-124 31299628-5 2019 The IL-6 protein can be detected by this method with very low detection limits by monitoring the intensity of the characteristic Raman peak of the IL-6-conjugated SERS tags at 1332 cm-1. sers 163-167 interleukin 6 Homo sapiens 4-8 31299628-5 2019 The IL-6 protein can be detected by this method with very low detection limits by monitoring the intensity of the characteristic Raman peak of the IL-6-conjugated SERS tags at 1332 cm-1. sers 163-167 interleukin 6 Homo sapiens 147-151 31393497-0 2019 Highly sensitive detection of prostate cancer specific PCA3 mimic DNA using SERS-based competitive lateral flow assay. sers 76-80 prostate cancer associated 3 Homo sapiens 55-59 31361124-9 2019 For in vivo SERS detection, Raman shift peaks of 2120, 2205, and 2230 cm-1 in the micro-tumor were clearly observed, representing the existence of three specific biomarkers of nucleolin, integrin alphavbeta3, and CD44 reporter, which could be used for early cancer phenotype identification. sers 12-16 nucleolin Homo sapiens 176-185 31393497-3 2019 In this study, we developed a novel surface-enhanced Raman scattering (SERS)-based competitive LFA for the rapid and highly sensitive quantitative evaluation of prostate cancer antigen 3 (PCA3) mimic DNA. sers 71-75 prostate cancer associated 3 Homo sapiens 161-186 31393497-3 2019 In this study, we developed a novel surface-enhanced Raman scattering (SERS)-based competitive LFA for the rapid and highly sensitive quantitative evaluation of prostate cancer antigen 3 (PCA3) mimic DNA. sers 71-75 prostate cancer associated 3 Homo sapiens 188-192 31393497-4 2019 Herein, the competitive hybridization interaction with capture DNA between target PCA3 mimic DNA and reporter DNA-labeled SERS nanotags results in a change in the amount of SERS nanotags on the test line. sers 122-126 prostate cancer associated 3 Homo sapiens 82-86 31393497-4 2019 Herein, the competitive hybridization interaction with capture DNA between target PCA3 mimic DNA and reporter DNA-labeled SERS nanotags results in a change in the amount of SERS nanotags on the test line. sers 173-177 prostate cancer associated 3 Homo sapiens 82-86 31393497-5 2019 The quantitative analysis of target PCA3 mimic DNA was realized by monitoring the Raman peak intensity of SERS nanotags on the test line. sers 106-110 prostate cancer associated 3 Homo sapiens 36-40 31408931-4 2019 To accomplish this, we developed a hydrogel consisting of polyelectrolyte multilayer microcapsules containing a SERS-sensitive pH reporter (4-mercapopyridine capped silver nanoparticles modified with bovine serum albumin). sers 112-116 albumin Homo sapiens 207-220 31290645-4 2019 Consequently, the detection of GGT is achieved based on both plasmonic fluorescent enhancement and SERS with a detection limit as low as 1.2 x 10-3 U/L (normal range for GGT levels in the blood is 9-48 U/L). sers 99-103 inactive glutathione hydrolase 2 Homo sapiens 31-34 31303905-4 2019 This supramolecular complexation allows DNT to be positioned in close proximity to the plasmonic hotspots within aggregates of CB[7] and gold nanoparticles, resulting in significant SERS signals with a detection limit of ~1 muM. sers 182-186 latexin Homo sapiens 224-227 31143920-7 2019 SERS was used to determine the presence and concentration of miRNA-17 based on the formation of plasmonic nanoparticle aggregates. sers 0-4 microRNA 17 Homo sapiens 61-69 31143920-10 2019 These results demonstrate SERS"s specificity and sensitivity for a new biomarker (miRNA-17) that may ultimately be used in a detection platform for early diagnosis of preeclampsia. sers 26-30 microRNA 17 Homo sapiens 82-90 31157328-2 2019 Herein, a surface-enhanced Raman scattering (SERS)-based vertical flow assay (VFA) is presented for simultaneous detection of multiplex prostate cancer biomarkers, such as prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) on a single test spot. sers 45-49 kallikrein related peptidase 3 Homo sapiens 172-203 31157328-2 2019 Herein, a surface-enhanced Raman scattering (SERS)-based vertical flow assay (VFA) is presented for simultaneous detection of multiplex prostate cancer biomarkers, such as prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) on a single test spot. sers 45-49 CEA cell adhesion molecule 3 Homo sapiens 205-229 31157328-2 2019 Herein, a surface-enhanced Raman scattering (SERS)-based vertical flow assay (VFA) is presented for simultaneous detection of multiplex prostate cancer biomarkers, such as prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) on a single test spot. sers 45-49 CEA cell adhesion molecule 3 Homo sapiens 231-234 31157328-2 2019 Herein, a surface-enhanced Raman scattering (SERS)-based vertical flow assay (VFA) is presented for simultaneous detection of multiplex prostate cancer biomarkers, such as prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) on a single test spot. sers 45-49 alpha fetoprotein Homo sapiens 241-258 31157328-2 2019 Herein, a surface-enhanced Raman scattering (SERS)-based vertical flow assay (VFA) is presented for simultaneous detection of multiplex prostate cancer biomarkers, such as prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), and alpha-fetoprotein (AFP) on a single test spot. sers 45-49 alpha fetoprotein Homo sapiens 260-263 31078821-2 2019 Surface-enhanced Raman scattering (SERS) and tip enhanced Raman spectroscopy (TERS) are considered promising techniques for the study of catalytic reactions due to the highly localized sensitivity of SERS and the nanoscale spatial resolution of TERS. sers 200-204 TOR signaling pathway regulator Homo sapiens 45-48 30947989-0 2019 One-step fabrication of dopamine-inspired Au for SERS sensing of Cd2+ and polycyclic aromatic hydrocarbons. sers 49-53 CD2 molecule Homo sapiens 65-68 30947989-7 2019 More interestingly, the two-dimensional correlation spectroscopy showed that DQ modified Au exhibited a strong binding ability towards Cd2+, yielding SERS vibrational profiles that allowed the qualitative determination of Cd2+ with a detection limit of 10-8 mol L-1. sers 150-154 CD2 molecule Homo sapiens 135-138 30947989-7 2019 More interestingly, the two-dimensional correlation spectroscopy showed that DQ modified Au exhibited a strong binding ability towards Cd2+, yielding SERS vibrational profiles that allowed the qualitative determination of Cd2+ with a detection limit of 10-8 mol L-1. sers 150-154 CD2 molecule Homo sapiens 222-225 31321545-0 2019 A SERS-based lateral flow assay for the stroke biomarker S100-beta. sers 2-6 S100 calcium binding protein A1 Homo sapiens 57-66 31321545-7 2019 Graphical abstract Schematic illustration of the configuration (A) and the principle of the SERS-based lateral flow assay for quantification of S100-beta (B). sers 92-96 S100 calcium binding protein A1 Homo sapiens 144-153 31292460-0 2019 A dual-model SERS and RRS analytical platform for Pb(II) based on Ag-doped carbon dot catalytic amplification and aptamer regulation. sers 13-17 submaxillary gland androgen regulated protein 3B Homo sapiens 50-56 31292460-6 2019 The dual-model signals of SERS and RRS increased linearly with Pb(II) concentration increase within the scope of 0.006-0.46 mumol/L and 0.01-0.46 mumol/L. sers 26-30 submaxillary gland androgen regulated protein 3B Homo sapiens 63-69 31163601-3 2019 In this study, Opto Trace Raman 202 (OTR 202) was used as surface enhanced Raman spectroscopy (SERS) active colloids to detect sildenafil. sers 95-99 oxytocin receptor Homo sapiens 37-40 31135010-3 2019 We present results applying the use of surface enhanced Raman spectroscopy (SERS) to detect MxA. sers 76-80 MX dynamin like GTPase 1 Homo sapiens 92-95 30963650-3 2019 Owing to the designed circle amplification of miRNA and high SERS effects of CuPc on h-BNNS, miR-21 responsive concentration was achieved as low as 0.7 fm in live cells. sers 61-65 microRNA 21 Homo sapiens 93-99 30849493-7 2019 Surface-enhanced raman spectroscopy (SERS) indicated that nitration of hIAPP impaired the intermolecular hydrogen bonding. sers 37-41 islet amyloid polypeptide Homo sapiens 71-76 31062578-7 2019 Both the SERS and SEM results showed that we completely eliminated the nonspecific binding of Au NPs onto the optimally anti-CRP-immobilized Au nanoplate. sers 9-13 C-reactive protein Homo sapiens 125-128 30916930-0 2019 Electrochemistry-Regulated Recyclable SERS Sensor for Sensitive and Selective Detection of Tyrosinase Activity. sers 38-42 tyrosinase Homo sapiens 91-101 30965560-1 2019 In this study, 4-mercaptobenzoic acid (MBA)-Au nanorods conjugated with a GPR120 antibody were developed as a highly sensitive surface-enhanced Raman spectroscopy (SERS) probe, and were applied to detect the interaction of fatty acids (FA) and their cognate receptor, GPR120, on the surface of human embryonic kidney cells (HEK293-GPRR120) cultured in a polydimethylsiloxane (PDMS) microfluidic device. sers 164-168 free fatty acid receptor 4 Homo sapiens 74-80 30825867-5 2019 Surface-enhanced Raman scattering (SERS) was used to monitor the geometry of adsorbate, separate, enrich, and detect various bombesin C-terminal fragments. sers 35-39 gastrin releasing peptide Homo sapiens 125-133 31066245-3 2019 Specifically, a surface-enhanced Raman spectroscopy (SERS)-based approach and assay were designed, developed, and tested for sensitive and rapid detection of S100P mRNA. sers 53-57 S100 calcium binding protein P Homo sapiens 158-163 31066245-5 2019 The hybridization of S100P target to DNA-conjugated AuNPs in sandwich assay format in both free solution and a vertical flow chip (VFC) was confirmed using a handheld SERS system. sers 167-171 S100 calcium binding protein P Homo sapiens 21-26 31066245-7 2019 SERS-based VFCs were also used to quantify the S100P mRNA from saliva samples of oral cancer patients and a healthy group. sers 0-4 S100 calcium binding protein P Homo sapiens 47-52 30864786-0 2019 SERS-Based Pump-Free Microfluidic Chip for Highly Sensitive Immunoassay of Prostate-Specific Antigen Biomarkers. sers 0-4 kallikrein related peptidase 3 Homo sapiens 75-100 30916930-2 2019 Herein, we develop a novel portable and recyclable surface-enhanced Raman scattering (SERS) sensor, prepared by assembling gold nanoparticles and p-thiol catechol ( p-TC) on an ITO electrode, for detecting TYR activity via the SERS spectral variation caused by the conversion of p-TC into its corresponding quinone under TYR catalysis. sers 86-90 tyrosinase Homo sapiens 206-209 30916930-2 2019 Herein, we develop a novel portable and recyclable surface-enhanced Raman scattering (SERS) sensor, prepared by assembling gold nanoparticles and p-thiol catechol ( p-TC) on an ITO electrode, for detecting TYR activity via the SERS spectral variation caused by the conversion of p-TC into its corresponding quinone under TYR catalysis. sers 86-90 tyrosinase Homo sapiens 321-324 30916930-3 2019 The developed SERS sensor has a rapid response to TYR within 1 min under the optimized conditions and shows high selectivity for TYR with the detection limit at 0.07 U/mL. sers 14-18 tyrosinase Homo sapiens 50-53 30916930-3 2019 The developed SERS sensor has a rapid response to TYR within 1 min under the optimized conditions and shows high selectivity for TYR with the detection limit at 0.07 U/mL. sers 14-18 tyrosinase Homo sapiens 129-132 30916930-5 2019 Furthermore, the presented recyclable SERS sensor can perform well on both the determination of TYR activity in serum and the assessment of TYR inhibitor, demonstrating huge potential in the sensitive, selective, and facile detection of TYR activity for disease diagnosis and drug screening related with TYR. sers 38-42 tyrosinase Homo sapiens 96-99 30916930-5 2019 Furthermore, the presented recyclable SERS sensor can perform well on both the determination of TYR activity in serum and the assessment of TYR inhibitor, demonstrating huge potential in the sensitive, selective, and facile detection of TYR activity for disease diagnosis and drug screening related with TYR. sers 38-42 tyrosinase Homo sapiens 140-143 30916930-5 2019 Furthermore, the presented recyclable SERS sensor can perform well on both the determination of TYR activity in serum and the assessment of TYR inhibitor, demonstrating huge potential in the sensitive, selective, and facile detection of TYR activity for disease diagnosis and drug screening related with TYR. sers 38-42 tyrosinase Homo sapiens 140-143 30916930-5 2019 Furthermore, the presented recyclable SERS sensor can perform well on both the determination of TYR activity in serum and the assessment of TYR inhibitor, demonstrating huge potential in the sensitive, selective, and facile detection of TYR activity for disease diagnosis and drug screening related with TYR. sers 38-42 tyrosinase Homo sapiens 140-143 31115772-6 2019 The SA expression levels on different cell lines (MCF-7, HepG2, SGC and BNL.CL2) traced by SERS spectroscopy were compared. sers 91-95 acyl-CoA synthetase medium chain family member 3 Homo sapiens 4-6 30965560-1 2019 In this study, 4-mercaptobenzoic acid (MBA)-Au nanorods conjugated with a GPR120 antibody were developed as a highly sensitive surface-enhanced Raman spectroscopy (SERS) probe, and were applied to detect the interaction of fatty acids (FA) and their cognate receptor, GPR120, on the surface of human embryonic kidney cells (HEK293-GPRR120) cultured in a polydimethylsiloxane (PDMS) microfluidic device. sers 164-168 free fatty acid receptor 4 Homo sapiens 268-274 30935114-5 2019 Using alpha-fetoprotein as a model analyte for immunoassay, the SERS signal had a wide linear range of 0.20 ng mL-1 to 500.0 ng mL-1 with a detection limit of 0.12 ng mL-1. sers 64-68 alpha fetoprotein Homo sapiens 6-23 30935114-5 2019 Using alpha-fetoprotein as a model analyte for immunoassay, the SERS signal had a wide linear range of 0.20 ng mL-1 to 500.0 ng mL-1 with a detection limit of 0.12 ng mL-1. sers 64-68 L1 cell adhesion molecule Mus musculus 111-115 30935114-5 2019 Using alpha-fetoprotein as a model analyte for immunoassay, the SERS signal had a wide linear range of 0.20 ng mL-1 to 500.0 ng mL-1 with a detection limit of 0.12 ng mL-1. sers 64-68 L1 cell adhesion molecule Mus musculus 128-132 30935114-5 2019 Using alpha-fetoprotein as a model analyte for immunoassay, the SERS signal had a wide linear range of 0.20 ng mL-1 to 500.0 ng mL-1 with a detection limit of 0.12 ng mL-1. sers 64-68 L1 cell adhesion molecule Mus musculus 128-132 30666995-0 2019 A graphene oxide/gold nanoparticle-based amplification method for SERS immunoassay of cardiac troponin I. sers 66-70 troponin I3, cardiac type Homo sapiens 86-104 30609543-2 2019 In this work, a simple and reproducible SERS substrate combining the properties of multi-walled carbon nanotubes (MWCNTs) and gold nanoparticles (AuNPs), is proposed for the determination and quantification of sulfapyridine in milk samples with a concentration range of 10-100 ng mL-1. sers 40-44 L1 cell adhesion molecule Mus musculus 280-284 30666995-2 2019 Herein, a new signal amplification surface-enhanced Raman scattering (SERS) platform was developed for recognition and detection of cTnI by using gold nanoparticles (AuNPs), graphene oxide (GO) and magnetic beads (MB). sers 70-74 troponin I3, cardiac type Homo sapiens 132-136 30666995-5 2019 In the presence of cTnI, sandwich type immunocomplexes, "capture probe/target/SERS nanotags", were formed through antibody-antigen-antibody interactions. sers 78-82 troponin I3, cardiac type Homo sapiens 19-23 30666995-6 2019 Due to the strong SERS enhancement ability of the designed GO/AuNP complexes and a high binding chance between cTnI and the GO/AuNP complexes, the proposed SERS-based immunoassay could selectively detect cTnI with a high sensitivity (detection limit of 5 pg mL-1) and a good linearity was obtained in a range of 0.01-1000 ng mL-1. sers 18-22 troponin I3, cardiac type Homo sapiens 204-208 30666995-6 2019 Due to the strong SERS enhancement ability of the designed GO/AuNP complexes and a high binding chance between cTnI and the GO/AuNP complexes, the proposed SERS-based immunoassay could selectively detect cTnI with a high sensitivity (detection limit of 5 pg mL-1) and a good linearity was obtained in a range of 0.01-1000 ng mL-1. sers 156-160 troponin I3, cardiac type Homo sapiens 111-115 30666995-6 2019 Due to the strong SERS enhancement ability of the designed GO/AuNP complexes and a high binding chance between cTnI and the GO/AuNP complexes, the proposed SERS-based immunoassay could selectively detect cTnI with a high sensitivity (detection limit of 5 pg mL-1) and a good linearity was obtained in a range of 0.01-1000 ng mL-1. sers 156-160 troponin I3, cardiac type Homo sapiens 204-208 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 45-49 alpha fetoprotein Homo sapiens 183-186 30547173-0 2019 AuNP-peptide probe for caspase-3 detection in living cells by SERS. sers 62-66 caspase 3 Homo sapiens 23-32 30547173-4 2019 In addition, the PFF (Pro-Phe-Phe) or KYD (Lys-Tyr-Asp) was exposed and interacted via the hydrophobic or alternate negative and positive electro-interaction in the presence of caspase-3, inducing the aggregation of colloidal Au-peptides accompanied with the enhancement of SERS. sers 274-278 caspase 3 Homo sapiens 177-186 30547173-5 2019 It can be observed that the SERS-enhanced signals were correlated with the caspase-3 concentrations and the limit of detection can reach 1.5 ng mL-1. sers 28-32 caspase 3 Homo sapiens 75-84 30624040-6 2019 The proposed nanoprobes could be applied to targeted detection and SERS imaging of nucleolin-overexpressing cancer cells (MCF-7 cells as the model) from normal cells and also exhibited acceptable photothermal efficacy without systematic toxicity. sers 67-71 nucleolin Homo sapiens 83-92 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 75-79 alpha fetoprotein Homo sapiens 183-186 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 75-79 CEA cell adhesion molecule 3 Homo sapiens 199-202 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 75-79 alpha fetoprotein Homo sapiens 183-186 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 45-49 CEA cell adhesion molecule 3 Homo sapiens 199-202 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 75-79 alpha fetoprotein Homo sapiens 183-186 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 75-79 CEA cell adhesion molecule 3 Homo sapiens 199-202 30689353-4 2019 Here, three triple bonds (C N and C C) coded SERS tags contribute separate SERS emissions located at 2105, 2159, and 2227 cm-1, respectively; must have one-to-one correspondence from AFP, to FER, to CEA, In the process of detection, the mature double antibody sandwich allows the formation of microscale core-satellite assembly structure between a magnetic bead (MB) and single SERS tags, and therefore a pure and single SERS emission can be observed under the routine excitation laser spot. sers 75-79 CEA cell adhesion molecule 3 Homo sapiens 199-202 30689353-7 2019 Herein, the limit of detection (LOD) for simultaneous m-SERS detection of AFP, CEA, and FER was 0.15, 20, and 4 pg/mL, respectively. sers 56-60 alpha fetoprotein Homo sapiens 74-77 30624061-7 2019 By using this ultrasensitive SERS-microdroplet method, the VEGF and IL-8 secretions from several cells in one droplet were explored and the data show that the cell-cell interaction may promote angiogenesis of cancer cells through the up-regulation of VEGF and IL-8. sers 29-33 vascular endothelial growth factor A Homo sapiens 59-63 30689353-7 2019 Herein, the limit of detection (LOD) for simultaneous m-SERS detection of AFP, CEA, and FER was 0.15, 20, and 4 pg/mL, respectively. sers 56-60 CEA cell adhesion molecule 3 Homo sapiens 79-82 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 4-8 plasminogen activator, urokinase receptor Homo sapiens 87-128 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 4-8 plasminogen activator, urokinase receptor Homo sapiens 130-134 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 4-8 epidermal growth factor receptor Homo sapiens 141-173 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 4-8 epidermal growth factor receptor Homo sapiens 175-179 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 51-55 plasminogen activator, urokinase receptor Homo sapiens 87-128 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 51-55 plasminogen activator, urokinase receptor Homo sapiens 130-134 30624061-7 2019 By using this ultrasensitive SERS-microdroplet method, the VEGF and IL-8 secretions from several cells in one droplet were explored and the data show that the cell-cell interaction may promote angiogenesis of cancer cells through the up-regulation of VEGF and IL-8. sers 29-33 vascular endothelial growth factor A Homo sapiens 251-255 30624061-7 2019 By using this ultrasensitive SERS-microdroplet method, the VEGF and IL-8 secretions from several cells in one droplet were explored and the data show that the cell-cell interaction may promote angiogenesis of cancer cells through the up-regulation of VEGF and IL-8. sers 29-33 C-X-C motif chemokine ligand 8 Homo sapiens 260-264 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 51-55 epidermal growth factor receptor Homo sapiens 141-173 32254856-2 2019 Two SERS nanoprobes that are encoded with distinct SERS signatures are conjugated with urokinase plasminogen activation receptor (uPAR)- and epidermal growth factor receptor (EGFR)-targeting peptides. sers 51-55 epidermal growth factor receptor Homo sapiens 175-179 32254856-4 2019 The results show that MDA-MB-231 and MCF-7 exhibit distinct expression of the uPAR and EGFR and they can be respectively discriminated by the intensity ratio of SERS signals from uPAR- and EGFR-targeting SERS nanoprobes. sers 161-165 plasminogen activator, urokinase receptor Homo sapiens 78-82 32254856-4 2019 The results show that MDA-MB-231 and MCF-7 exhibit distinct expression of the uPAR and EGFR and they can be respectively discriminated by the intensity ratio of SERS signals from uPAR- and EGFR-targeting SERS nanoprobes. sers 161-165 epidermal growth factor receptor Homo sapiens 87-91 30624061-7 2019 By using this ultrasensitive SERS-microdroplet method, the VEGF and IL-8 secretions from several cells in one droplet were explored and the data show that the cell-cell interaction may promote angiogenesis of cancer cells through the up-regulation of VEGF and IL-8. sers 29-33 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 30650258-2 2019 The concentration of Pd2+ is the key factor for the density of Pd nanoparticles (Pd NPs) embedded in the carbon shells, which plays a role in the oxygen reduction reaction (ORR) and surface-enhanced Raman scattering (SERS) properties. sers 217-221 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 21-24 32254856-4 2019 The results show that MDA-MB-231 and MCF-7 exhibit distinct expression of the uPAR and EGFR and they can be respectively discriminated by the intensity ratio of SERS signals from uPAR- and EGFR-targeting SERS nanoprobes. sers 161-165 plasminogen activator, urokinase receptor Homo sapiens 179-183 32254856-4 2019 The results show that MDA-MB-231 and MCF-7 exhibit distinct expression of the uPAR and EGFR and they can be respectively discriminated by the intensity ratio of SERS signals from uPAR- and EGFR-targeting SERS nanoprobes. sers 161-165 epidermal growth factor receptor Homo sapiens 189-193 32254856-4 2019 The results show that MDA-MB-231 and MCF-7 exhibit distinct expression of the uPAR and EGFR and they can be respectively discriminated by the intensity ratio of SERS signals from uPAR- and EGFR-targeting SERS nanoprobes. sers 204-208 plasminogen activator, urokinase receptor Homo sapiens 78-82 32254856-4 2019 The results show that MDA-MB-231 and MCF-7 exhibit distinct expression of the uPAR and EGFR and they can be respectively discriminated by the intensity ratio of SERS signals from uPAR- and EGFR-targeting SERS nanoprobes. sers 204-208 epidermal growth factor receptor Homo sapiens 87-91 32254856-4 2019 The results show that MDA-MB-231 and MCF-7 exhibit distinct expression of the uPAR and EGFR and they can be respectively discriminated by the intensity ratio of SERS signals from uPAR- and EGFR-targeting SERS nanoprobes. sers 204-208 epidermal growth factor receptor Homo sapiens 189-193 30555993-7 2018 We observed the characteristic SERS peaks of cAMP when DRD1-overexpressed cells interact with the signaling compounds; these peaks were not observed for other cells including DRD2-overexpressed and DRD1-DRD2-coexpressed cells. sers 31-35 dopamine receptor D1 Homo sapiens 55-59 30671571-3 2019 Herein, we developed a surface enhanced Raman scattering (SERS)-based sandwich-type immunoassay for the simultaneous detection of two surface markers (i.e., CD19 and CD20) in Raji cell lines as well as in clinical blood samples. sers 58-62 CD19 molecule Homo sapiens 157-161 30671571-3 2019 Herein, we developed a surface enhanced Raman scattering (SERS)-based sandwich-type immunoassay for the simultaneous detection of two surface markers (i.e., CD19 and CD20) in Raji cell lines as well as in clinical blood samples. sers 58-62 keratin 20 Homo sapiens 166-170 30671571-4 2019 First, to compare with the results obtained by flow cytometry, we evaluated the sensitivity and reproducibility of the SERS immunoassay for real-time detection of CD19 and CD20 expressions in Raji cells and blood samples. sers 119-123 CD19 molecule Homo sapiens 163-167 30671571-4 2019 First, to compare with the results obtained by flow cytometry, we evaluated the sensitivity and reproducibility of the SERS immunoassay for real-time detection of CD19 and CD20 expressions in Raji cells and blood samples. sers 119-123 keratin 20 Homo sapiens 172-176 30671571-6 2019 In addition to the improved sensitivity of the SERS method, good linear correlations between the SERS intensities and flow cytometry results were also observed for both CD19 and CD20, which indicated the accuracy of this SERS-based strategy. sers 97-101 CD19 molecule Homo sapiens 169-173 30671571-6 2019 In addition to the improved sensitivity of the SERS method, good linear correlations between the SERS intensities and flow cytometry results were also observed for both CD19 and CD20, which indicated the accuracy of this SERS-based strategy. sers 97-101 keratin 20 Homo sapiens 178-182 30671571-6 2019 In addition to the improved sensitivity of the SERS method, good linear correlations between the SERS intensities and flow cytometry results were also observed for both CD19 and CD20, which indicated the accuracy of this SERS-based strategy. sers 97-101 CD19 molecule Homo sapiens 169-173 30671571-6 2019 In addition to the improved sensitivity of the SERS method, good linear correlations between the SERS intensities and flow cytometry results were also observed for both CD19 and CD20, which indicated the accuracy of this SERS-based strategy. sers 97-101 keratin 20 Homo sapiens 178-182 30608142-0 2019 Growth of Spherical Gold Satellites on the Surface of Au@Ag@SiO2 Core-Shell Nanostructures Used for an Ultrasensitive SERS Immunoassay of Alpha-Fetoprotein. sers 118-122 alpha fetoprotein Homo sapiens 138-155 30608142-7 2019 For specific detection of alpha-fetoprotein (AFP), we utilized the SERS-active core-shell-satellite nanostructures modified with AFP antibody as immune probes and nitrocellulose membrane (NC) stabilized captured anti-AFP antibodies as solid substrate. sers 67-71 alpha fetoprotein Homo sapiens 26-43 30608142-7 2019 For specific detection of alpha-fetoprotein (AFP), we utilized the SERS-active core-shell-satellite nanostructures modified with AFP antibody as immune probes and nitrocellulose membrane (NC) stabilized captured anti-AFP antibodies as solid substrate. sers 67-71 alpha fetoprotein Homo sapiens 45-48 30608142-9 2019 Under the optimized conditions, AFP could be detected by the SERS-based sandwich immunoassay with an ultralow detection limit of 0.3 fg/mL, and the method exhibited a wide linear response from 1 fg/mL to 1 ng/mL. sers 61-65 alpha fetoprotein Homo sapiens 32-35 30566339-4 2019 Herein, expanding beyond conventional SERS substrates, we demonstrate that metal-organic framework (MOF) materials can serve as a type of SERS substrate with molecular selectivity, which are rarely realized for SERS detection without any special pretreatment. sers 38-42 lysine acetyltransferase 8 Homo sapiens 75-104 30566339-4 2019 Herein, expanding beyond conventional SERS substrates, we demonstrate that metal-organic framework (MOF) materials can serve as a type of SERS substrate with molecular selectivity, which are rarely realized for SERS detection without any special pretreatment. sers 138-142 lysine acetyltransferase 8 Homo sapiens 75-104 30566339-4 2019 Herein, expanding beyond conventional SERS substrates, we demonstrate that metal-organic framework (MOF) materials can serve as a type of SERS substrate with molecular selectivity, which are rarely realized for SERS detection without any special pretreatment. sers 138-142 lysine acetyltransferase 8 Homo sapiens 75-104 30566339-5 2019 A salient structural characteristic of MOF-based SERS substrates benefiting the SERS selectivity is their high tailorability. sers 49-53 lysine acetyltransferase 8 Homo sapiens 39-42 30566339-5 2019 A salient structural characteristic of MOF-based SERS substrates benefiting the SERS selectivity is their high tailorability. sers 80-84 lysine acetyltransferase 8 Homo sapiens 39-42 30566339-6 2019 By controlling the metal centers, organic ligands, and framework topologies of our MOF-based SERS substrates, we show that the electronic band structures of MOF-based SERS substrate can be purposively manipulated to match those of the target analytes, thus resulting in different detectable species. sers 93-97 lysine acetyltransferase 8 Homo sapiens 83-86 30566339-6 2019 By controlling the metal centers, organic ligands, and framework topologies of our MOF-based SERS substrates, we show that the electronic band structures of MOF-based SERS substrate can be purposively manipulated to match those of the target analytes, thus resulting in different detectable species. sers 93-97 lysine acetyltransferase 8 Homo sapiens 157-160 30566339-6 2019 By controlling the metal centers, organic ligands, and framework topologies of our MOF-based SERS substrates, we show that the electronic band structures of MOF-based SERS substrate can be purposively manipulated to match those of the target analytes, thus resulting in different detectable species. sers 167-171 lysine acetyltransferase 8 Homo sapiens 83-86 30566339-6 2019 By controlling the metal centers, organic ligands, and framework topologies of our MOF-based SERS substrates, we show that the electronic band structures of MOF-based SERS substrate can be purposively manipulated to match those of the target analytes, thus resulting in different detectable species. sers 167-171 lysine acetyltransferase 8 Homo sapiens 157-160 30566339-7 2019 Going further, the SERS enhancement factors (EFs) of the MOF-based SERS substrates can be greatly enhanced to as high as 106 with a low detection limit of 10-8 M by pore-structure optimization and surface modification, which is comparable to the EFs of noble metals without "hot spots" and recently reported semiconductors. sers 19-23 lysine acetyltransferase 8 Homo sapiens 57-60 30566339-7 2019 Going further, the SERS enhancement factors (EFs) of the MOF-based SERS substrates can be greatly enhanced to as high as 106 with a low detection limit of 10-8 M by pore-structure optimization and surface modification, which is comparable to the EFs of noble metals without "hot spots" and recently reported semiconductors. sers 67-71 lysine acetyltransferase 8 Homo sapiens 57-60 28748768-8 2019 Topics discussed include, identification of small molecule inhibitors targeting AurA- Targeting Protein for Xenopus kinesin-like protein 2 (TPX2) interaction, anacardic acid - a natural product ligand that selectively modulates AurA activity in the presence of Aurora B kinase, and identification of felodipine as an uncompetitive inhibitor of AurA using Surface Enhanced Raman Spectroscopy (SERS) technique. sers 392-396 aurora kinase A S homeolog Xenopus laevis 80-84 31343381-0 2019 Raman and SERS spectra of thiamethoxam and the Ag3-thiamethoxam complex: an experimental and theoretical investigation. sers 10-14 anterior gradient 3, protein disulphide isomerase family member Homo sapiens 47-50 30392659-2 2018 Accordingly, herein a novel surface-enhanced Raman scattering (SERS) nanoprobe is prepared via the co-assembly of 3-(4-(phenylethynyl)benzylthio) propanoic acid (PEB) tagged-peptides and 4-thiol phenylacetylene (TPA) on gold nanorods, and used for the measurement of caspase 3, as a biomarker. sers 63-67 caspase 3 Rattus norvegicus 267-276 30774440-0 2019 SERS-based detection of haptoglobin in ovarian cyst fluid as a point-of-care diagnostic assay for epithelial ovarian cancer. sers 0-4 haptoglobin Homo sapiens 24-35 30499654-0 2019 Plasmon Near-Field Coupling of Bimetallic Nanostars and a Hierarchical Bimetallic SERS "Hot Field": Toward Ultrasensitive Simultaneous Detection of Multiple Cardiorenal Syndrome Biomarkers. sers 82-86 alcohol dehydrogenase iron containing 1 Homo sapiens 88-91 30499654-5 2019 When the nanotags and substrate were combined, "hot spots" were generated from the plasmon near-field coupling, which greatly increased the SERS enhancement. sers 140-144 alcohol dehydrogenase iron containing 1 Homo sapiens 48-51 30420985-1 2018 The interaction of bovine serum albumin (BSA) and human serum albumin (HSA), sharing a sequence similarity of 77.5%, with gold nanoparticles of a size of ~30 nm was investigated by surface-enhanced Raman scattering (SERS). sers 216-220 albumin Homo sapiens 26-39 30420985-1 2018 The interaction of bovine serum albumin (BSA) and human serum albumin (HSA), sharing a sequence similarity of 77.5%, with gold nanoparticles of a size of ~30 nm was investigated by surface-enhanced Raman scattering (SERS). sers 216-220 albumin Homo sapiens 56-69 30555993-7 2018 We observed the characteristic SERS peaks of cAMP when DRD1-overexpressed cells interact with the signaling compounds; these peaks were not observed for other cells including DRD2-overexpressed and DRD1-DRD2-coexpressed cells. sers 31-35 dopamine receptor D2 Homo sapiens 203-207 30121424-2 2018 In this study, we developed a novel, surface-enhanced Raman scattering (SERS)-based microfluidic device for the simultaneous detection of free prostate-specific antigen (f-PSA) and total PSA (t-PSA) markers. sers 72-76 kallikrein related peptidase 3 Homo sapiens 143-175 30613292-5 2018 Results: SERS and BFNP were utilized to detect, discriminate and quantify ICAM-1, VCAM-1 and P-selectin in vitro on human endothelial cells and ex vivo in human coronary arteries. sers 9-13 intercellular adhesion molecule 1 Homo sapiens 74-80 30613292-5 2018 Results: SERS and BFNP were utilized to detect, discriminate and quantify ICAM-1, VCAM-1 and P-selectin in vitro on human endothelial cells and ex vivo in human coronary arteries. sers 9-13 vascular cell adhesion molecule 1 Homo sapiens 82-88 30613292-5 2018 Results: SERS and BFNP were utilized to detect, discriminate and quantify ICAM-1, VCAM-1 and P-selectin in vitro on human endothelial cells and ex vivo in human coronary arteries. sers 9-13 selectin P Homo sapiens 93-103 30463284-7 2018 The binding potential of our CD47-labeled SERS nanoparticles was assessed using fluorescence assisted cell sorting (FACS) on seven different human breast cancer cell lines, some of which were triple negative (negative expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2)). sers 42-46 progesterone receptor Homo sapiens 256-277 30463284-7 2018 The binding potential of our CD47-labeled SERS nanoparticles was assessed using fluorescence assisted cell sorting (FACS) on seven different human breast cancer cell lines, some of which were triple negative (negative expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2)). sers 42-46 progesterone receptor Homo sapiens 279-281 30463284-7 2018 The binding potential of our CD47-labeled SERS nanoparticles was assessed using fluorescence assisted cell sorting (FACS) on seven different human breast cancer cell lines, some of which were triple negative (negative expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2)). sers 42-46 erb-b2 receptor tyrosine kinase 2 Homo sapiens 294-328 30463284-7 2018 The binding potential of our CD47-labeled SERS nanoparticles was assessed using fluorescence assisted cell sorting (FACS) on seven different human breast cancer cell lines, some of which were triple negative (negative expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2)). sers 42-46 erb-b2 receptor tyrosine kinase 2 Homo sapiens 330-334 30121424-2 2018 In this study, we developed a novel, surface-enhanced Raman scattering (SERS)-based microfluidic device for the simultaneous detection of free prostate-specific antigen (f-PSA) and total PSA (t-PSA) markers. sers 72-76 kallikrein related peptidase 3 Homo sapiens 172-175 30121424-2 2018 In this study, we developed a novel, surface-enhanced Raman scattering (SERS)-based microfluidic device for the simultaneous detection of free prostate-specific antigen (f-PSA) and total PSA (t-PSA) markers. sers 72-76 kallikrein related peptidase 3 Homo sapiens 187-190 29920414-0 2018 The control of the adsorption of bovine serum albumin on mercaptan-modified gold thin films investigated by SERS spectroscopy. sers 108-112 albumin Homo sapiens 40-53 30112649-5 2018 In this work, method based on surface-enhanced Raman spectroscopy (SERS) was developed to investigate the influence of the time of the medical treatment using EDTA on exposure and accessibility of the growth factors, namely TGF-ss1, BMP-2, and bFGF on the dentine surface. sers 67-71 bone morphogenetic protein 2 Homo sapiens 233-238 30406203-0 2018 A novel ternary heterostructure with dramatic SERS activity for evaluation of PD-L1 expression at the single-cell level. sers 46-50 CD274 molecule Homo sapiens 78-83 30112649-5 2018 In this work, method based on surface-enhanced Raman spectroscopy (SERS) was developed to investigate the influence of the time of the medical treatment using EDTA on exposure and accessibility of the growth factors, namely TGF-ss1, BMP-2, and bFGF on the dentine surface. sers 67-71 fibroblast growth factor 2 Homo sapiens 244-248 30059864-0 2018 Label-free distinction between p53+/+ and p53 -/- colon cancer cells using a graphene based SERS platform. sers 92-96 tumor protein p53 Homo sapiens 31-34 30059864-1 2018 Surface-Enhanced Raman Scattering (SERS) is used to differentiate two colon cancer cell line HCT 116, that is, to distinguish a TP53 gene knockout cell line (p53 -/-) from a wild type (p53 +/+). sers 35-39 tumor protein p53 Homo sapiens 128-132 30059864-1 2018 Surface-Enhanced Raman Scattering (SERS) is used to differentiate two colon cancer cell line HCT 116, that is, to distinguish a TP53 gene knockout cell line (p53 -/-) from a wild type (p53 +/+). sers 35-39 tumor protein p53 Homo sapiens 158-161 30059864-1 2018 Surface-Enhanced Raman Scattering (SERS) is used to differentiate two colon cancer cell line HCT 116, that is, to distinguish a TP53 gene knockout cell line (p53 -/-) from a wild type (p53 +/+). sers 35-39 tumor protein p53 Homo sapiens 185-188 30209938-2 2018 The aim of this study was to develop surface-enhanced Raman scattering (SERS) approach for accurate determination of PPO activity in fruit and vegetables using the reduction in SERS intensity of catechol in reaction medium. sers 72-76 catechol oxidase B, chloroplastic Solanum tuberosum 117-120 30209938-2 2018 The aim of this study was to develop surface-enhanced Raman scattering (SERS) approach for accurate determination of PPO activity in fruit and vegetables using the reduction in SERS intensity of catechol in reaction medium. sers 177-181 catechol oxidase B, chloroplastic Solanum tuberosum 117-120 30209938-3 2018 Within a certain catechol concentration, when a purified PPO solution was analyzed, the reduction in SERS intensity (Delta I) was linear to PPO activity ( Ec) in a wide range of 500-50 000 U/L, and a linear regression equation of log Delta I/Delta t = 0.6223 log Ec + 0.8072, with a correlation coefficient of 0.9689 and a limit of detection of 224.65 U/L, was obtained. sers 101-105 catechol oxidase B, chloroplastic Solanum tuberosum 57-60 30209938-3 2018 Within a certain catechol concentration, when a purified PPO solution was analyzed, the reduction in SERS intensity (Delta I) was linear to PPO activity ( Ec) in a wide range of 500-50 000 U/L, and a linear regression equation of log Delta I/Delta t = 0.6223 log Ec + 0.8072, with a correlation coefficient of 0.9689 and a limit of detection of 224.65 U/L, was obtained. sers 101-105 catechol oxidase B, chloroplastic Solanum tuberosum 140-143 29885358-2 2018 The 5, 5"-dithiobis (2-nitrobenzoicacid) (DTNB) modified AuNFs and N-(1-adamantyl) ethylenediamine (AEDA) conjugated denatured BSA (AEDA-dBSA) was used as the SERS nanoprobe. sers 159-163 dystrobrevin beta Gallus gallus 42-46 30182714-1 2018 In this work, we have designed an efficient and rapid surface-enhanced Raman spectroscopy (SERS) immunosensor for a supersensitive analysis of hypersensitive C-reactive protein (hs-CRP) with a label-free method by combining porous magnetic Ni@C nanospheres to aggregate together for simplifying the experiment operation and CaCO3 microcapsule to encapsulate rhodamine B as the Raman signal. sers 91-95 C-reactive protein Homo sapiens 158-176 29959484-0 2018 Rapid and sensitive SERS detection of the cytokine tumor necrosis factor alpha (tnf-alpha) in a magnetic bead pull-down assay with purified and highly Raman-active gold nanoparticle clusters. sers 20-24 tumor necrosis factor Homo sapiens 51-78 29959484-0 2018 Rapid and sensitive SERS detection of the cytokine tumor necrosis factor alpha (tnf-alpha) in a magnetic bead pull-down assay with purified and highly Raman-active gold nanoparticle clusters. sers 20-24 tumor necrosis factor Homo sapiens 80-89 30059080-7 2018 In this review, we will first discuss different categories of SERS substrates including solution-phase, solid-supported, tip-enhanced Raman spectroscopy (TERS), and single-molecule substrates for biomolecular analysis. sers 62-66 TOR signaling pathway regulator Homo sapiens 121-124 30059089-1 2018 We report a structural investigation on IAPP, Abeta(1-40) and their equi-molar mixture aggregation pathway at nano-molar concentration using the Surface Enhanced Raman Spectroscopy (SERS) effect induced by silver metal colloids prepared by laser processes in solution and molecular dynamics simulations. sers 182-186 islet amyloid polypeptide Homo sapiens 40-44 30059089-2 2018 Our data show the ability of silver NPs coupled with SERS to detect secondary structures of IAPP, Abeta(1-40) and their 1 : 1 molar ratio mixture in the oligomeric state. sers 53-57 islet amyloid polypeptide Homo sapiens 92-96 30059089-4 2018 SERS spectroscopy shows both selectivity and sensitivity in detecting the secondary structures of hIAPP and Abeta(1-40) and to recognize both proteins in their mixture. sers 0-4 islet amyloid polypeptide Homo sapiens 98-103 29978695-3 2018 Here, we introduce plasmonic micropinball constructed from Au nanooctahedron as a three-dimensional surface-enhanced Raman spectroscopy (SERS) platform, enabling ultrasensitive detection of trace Hg2+ ions. sers 137-141 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 196-199 29978695-4 2018 Typically, strong SERS signals could be obtained when the single-stranded DNA structure converts to the hairpin structure in the presence of Hg2+ ions, due to the formation of thymine (T)-Hg2+-T. As a result, the detection limit of Hg2+ ions is as low as 1 x 10-16 M, which is far below compared to that reported for conventional analytical strategies. sers 18-22 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 141-144 29978695-4 2018 Typically, strong SERS signals could be obtained when the single-stranded DNA structure converts to the hairpin structure in the presence of Hg2+ ions, due to the formation of thymine (T)-Hg2+-T. As a result, the detection limit of Hg2+ ions is as low as 1 x 10-16 M, which is far below compared to that reported for conventional analytical strategies. sers 18-22 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 188-191 29978695-4 2018 Typically, strong SERS signals could be obtained when the single-stranded DNA structure converts to the hairpin structure in the presence of Hg2+ ions, due to the formation of thymine (T)-Hg2+-T. As a result, the detection limit of Hg2+ ions is as low as 1 x 10-16 M, which is far below compared to that reported for conventional analytical strategies. sers 18-22 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 188-191 30029370-7 2018 Furthermore, the serum levels of PSA, PSMA and hK2 in clinical samples were successfully detected using the SERS-based immunoassay platform, and correct classifications of PCa, BPH and healthy subjects were feasible with help of the linear SVM algorithm. sers 108-112 kallikrein related peptidase 3 Homo sapiens 33-36 30029370-7 2018 Furthermore, the serum levels of PSA, PSMA and hK2 in clinical samples were successfully detected using the SERS-based immunoassay platform, and correct classifications of PCa, BPH and healthy subjects were feasible with help of the linear SVM algorithm. sers 108-112 folate hydrolase 1 Homo sapiens 38-42 30029370-7 2018 Furthermore, the serum levels of PSA, PSMA and hK2 in clinical samples were successfully detected using the SERS-based immunoassay platform, and correct classifications of PCa, BPH and healthy subjects were feasible with help of the linear SVM algorithm. sers 108-112 RBPJ pseudogene 3 Homo sapiens 47-50 30160939-8 2018 CST-C was determined down to 1 pM and 62.5 nM by SERS and DPV, respectively, which satisfies the requirements for monitoring Alzheimer"s and kidney failure diseases. sers 49-53 cystatin C Homo sapiens 0-5 30014561-0 2018 A simple gold nanoplasmonic SERS method for trace Hg2+ based on aptamer-regulating graphene oxide catalysis. sers 28-32 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 50-53 30014561-5 2018 The enhanced SERS signal was linear to Hg2+ concentration in the range 0.25-10 nmol/L, with a detection limit of 0.08 nmol/L Hg2+ . sers 13-17 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 39-42 30014561-5 2018 The enhanced SERS signal was linear to Hg2+ concentration in the range 0.25-10 nmol/L, with a detection limit of 0.08 nmol/L Hg2+ . sers 13-17 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 125-128 29784385-7 2018 Meanwhile, a SERS nano-tag, synthesized by the conjugation of Apt1 to the surface of BSA coated and with 4-mercaptopyridine (4-Mpy) functionalized gold nanoparticles, was used to detect the isolated cells. sers 13-17 lysophospholipase 1 Homo sapiens 62-66 30036967-8 2018 Given the high selectivity and high sensitivity of SERS with a functionalized silver nanostructured plate (FSNP), we propose this method for identifying the presence of HER2 and consequently, of breast cancer cells. sers 51-55 erb-b2 receptor tyrosine kinase 2 Homo sapiens 169-173 31458956-2 2018 These were demonstrated as efficient SERS substrates for the detection of multiple explosive molecules such as picric acid (5 muM), 2,4-dinitrotoluene (1 muM), and 3-nitro-1,2,4-triazol-5-one (10 muM) along with a common dye molecule (methylene blue, 5 nM). sers 37-41 latexin Homo sapiens 126-129 31458956-2 2018 These were demonstrated as efficient SERS substrates for the detection of multiple explosive molecules such as picric acid (5 muM), 2,4-dinitrotoluene (1 muM), and 3-nitro-1,2,4-triazol-5-one (10 muM) along with a common dye molecule (methylene blue, 5 nM). sers 37-41 latexin Homo sapiens 154-157 31458956-2 2018 These were demonstrated as efficient SERS substrates for the detection of multiple explosive molecules such as picric acid (5 muM), 2,4-dinitrotoluene (1 muM), and 3-nitro-1,2,4-triazol-5-one (10 muM) along with a common dye molecule (methylene blue, 5 nM). sers 37-41 latexin Homo sapiens 154-157 29759204-2 2018 In principle, the thiolated 5"-Rox C-containing labeled aptamer probe (Rox-aptamer) is firstly immobilized on the SERS substrate surface and then hybridizes with the complementary DNA (cDNA) to form a rigid double-stranded DNA (dsDNA), in which the Rox Raman labels is used to produce the Raman signal. sers 114-118 MAX network transcriptional repressor Homo sapiens 31-34 29759204-2 2018 In principle, the thiolated 5"-Rox C-containing labeled aptamer probe (Rox-aptamer) is firstly immobilized on the SERS substrate surface and then hybridizes with the complementary DNA (cDNA) to form a rigid double-stranded DNA (dsDNA), in which the Rox Raman labels is used to produce the Raman signal. sers 114-118 MAX network transcriptional repressor Homo sapiens 71-74 29759204-2 2018 In principle, the thiolated 5"-Rox C-containing labeled aptamer probe (Rox-aptamer) is firstly immobilized on the SERS substrate surface and then hybridizes with the complementary DNA (cDNA) to form a rigid double-stranded DNA (dsDNA), in which the Rox Raman labels is used to produce the Raman signal. sers 114-118 MAX network transcriptional repressor Homo sapiens 71-74 30009009-3 2018 Furthermore, by analyzing a 2 muL clinical serum sample, the migration inhibitory factor (MIF) antibody-based SERS immunoassay could not only discriminate pancreatic cancer patients (n = 71) from healthy individuals (n = 32), but also distinguish metastasized tumors from metastasis-free tumors, and Tumor Node Metastasis (TNM) P1-2 stages from the P3 stage (the discriminatory sensitivity was 95.7%). sers 110-114 macrophage migration inhibitory factor Homo sapiens 61-88 29799180-4 2018 The annular nanogap arrays with a minimum diameter smaller than 100 nm and sub-1 nm gap width have been produced, showing excellent SERS performance with a typical enhancement factor up to 3.1 x 106 and a detection limit of 10-11 M. Moreover, it can also work as a high-quality field enhancement substrate for studying two-dimensional materials, such as MoSe2. sers 132-136 SUB1 regulator of transcription Homo sapiens 75-80 30009009-3 2018 Furthermore, by analyzing a 2 muL clinical serum sample, the migration inhibitory factor (MIF) antibody-based SERS immunoassay could not only discriminate pancreatic cancer patients (n = 71) from healthy individuals (n = 32), but also distinguish metastasized tumors from metastasis-free tumors, and Tumor Node Metastasis (TNM) P1-2 stages from the P3 stage (the discriminatory sensitivity was 95.7%). sers 110-114 macrophage migration inhibitory factor Homo sapiens 90-93 30009009-3 2018 Furthermore, by analyzing a 2 muL clinical serum sample, the migration inhibitory factor (MIF) antibody-based SERS immunoassay could not only discriminate pancreatic cancer patients (n = 71) from healthy individuals (n = 32), but also distinguish metastasized tumors from metastasis-free tumors, and Tumor Node Metastasis (TNM) P1-2 stages from the P3 stage (the discriminatory sensitivity was 95.7%). sers 110-114 DNA polymerase epsilon 4, accessory subunit Homo sapiens 328-332 29501193-3 2018 Herein, we have developed a strategy to fabricate SERS active substrates (Ag/LCP) based on liquid-crystal polymer (LCP) textile fibers decorated with Ag nanoparticles (NPs). sers 50-54 kelch domain containing 2 Homo sapiens 77-80 29577154-3 2018 Principal component analysis (PCA) combined with linear discriminant analysis (LDA) was employed to analyze the SERS spectra, revealing that the classification sensitivity and specificity were 90% and 78.9%, respectively, and the absolute value for loading of PC1 at 1509 cm-1 was the largest. sers 112-116 polycystin 1, transient receptor potential channel interacting Homo sapiens 260-263 29501193-9 2018 SERS active Ag/LCP/PA filter membranes were also prepared using Ag/LCP composites supported by a polyamide (PA) filter, which can be an easy alternative to prepare simple, highly efficient and low-cost SERS active filter membranes for water analysis. sers 202-206 kelch domain containing 2 Homo sapiens 12-21 29501193-9 2018 SERS active Ag/LCP/PA filter membranes were also prepared using Ag/LCP composites supported by a polyamide (PA) filter, which can be an easy alternative to prepare simple, highly efficient and low-cost SERS active filter membranes for water analysis. sers 202-206 kelch domain containing 2 Homo sapiens 15-18 29501193-3 2018 Herein, we have developed a strategy to fabricate SERS active substrates (Ag/LCP) based on liquid-crystal polymer (LCP) textile fibers decorated with Ag nanoparticles (NPs). sers 50-54 kelch domain containing 2 Homo sapiens 115-118 29501193-6 2018 The SERS analysis of thiram dissolved in Aveiro Estuary water and in fruit juices have provided enhancement factors of 1.67 x 107 and 3.86 x 105, respectively, using the Ag/LCP composites. sers 4-8 kelch domain containing 2 Homo sapiens 173-176 29501193-9 2018 SERS active Ag/LCP/PA filter membranes were also prepared using Ag/LCP composites supported by a polyamide (PA) filter, which can be an easy alternative to prepare simple, highly efficient and low-cost SERS active filter membranes for water analysis. sers 0-4 kelch domain containing 2 Homo sapiens 12-21 29501193-9 2018 SERS active Ag/LCP/PA filter membranes were also prepared using Ag/LCP composites supported by a polyamide (PA) filter, which can be an easy alternative to prepare simple, highly efficient and low-cost SERS active filter membranes for water analysis. sers 0-4 kelch domain containing 2 Homo sapiens 15-18 29431838-3 2018 The SERS nanosensor was prepared by self-assembling chemically synthesized gold triangular nanoprisms (Au TNPs), which we show display strong electromagnetic field enhancements at the sharp tips and edges, onto a pressure-sensitive flexible adhesive film. sers 4-8 C1GALT1 specific chaperone 1 Homo sapiens 106-110 29658693-2 2018 Owing to the lock effect from PZF, the surface-enhanced Raman scattering (SERS) tag toluidine blue (TB) connected on Ag NP-coating silica wafer was sheltered leading to low Raman response. sers 74-78 ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Homo sapiens 30-33 29658693-6 2018 The proposed SERS sensor can have a quantitative detection of PSA within the range of 1 pg mL-1 to 10 ng mL-1 with a detection limit of 0.65 pg mL-1. sers 13-17 kallikrein related peptidase 3 Homo sapiens 62-65 29658693-7 2018 The interaction between zinc finger peptide and Zn2+ was firstly applied in SERS sensor for the sensitive detection of PSA. sers 76-80 kallikrein related peptidase 3 Homo sapiens 119-122 29431838-4 2018 Our SERS nanosensor provides excellent SERS activity (enhancement factor = ~6.0 x 106) and limit of detection (as low as 56 parts-per-quadrillions) with high selectivity by chemometric analyses among three commonly military high explosives (TNT, RDX, and PETN). sers 4-8 chromosome 16 open reading frame 82 Homo sapiens 241-244 29648566-0 2018 SERS-based lateral flow assay for quantitative detection of C-reactive protein as an early bio-indicator of a radiation-induced inflammatory response in nonhuman primates. sers 0-4 C-reactive protein Homo sapiens 60-78 29648566-2 2018 A surface-enhanced Raman scattering (SERS)-based lateral flow assay was developed for the quantitative detection of C-reactive protein (CRP) as an early bio-indicator of a radiation-induced inflammatory response in nonhuman primates. sers 37-41 C-reactive protein Homo sapiens 116-134 29648566-2 2018 A surface-enhanced Raman scattering (SERS)-based lateral flow assay was developed for the quantitative detection of C-reactive protein (CRP) as an early bio-indicator of a radiation-induced inflammatory response in nonhuman primates. sers 37-41 C-reactive protein Homo sapiens 136-139 29648566-3 2018 Raman reporter-embedded gold-core silver-shell nanoparticles with built-in hot spots were synthesized and conjugated with a CRP detection antibody to serve as SERS tags in the lateral flow assay. sers 159-163 C-reactive protein Homo sapiens 124-127 29431838-4 2018 Our SERS nanosensor provides excellent SERS activity (enhancement factor = ~6.0 x 106) and limit of detection (as low as 56 parts-per-quadrillions) with high selectivity by chemometric analyses among three commonly military high explosives (TNT, RDX, and PETN). sers 4-8 radixin Homo sapiens 246-249 29648566-4 2018 The proposed SERS-based lateral flow assay can rapidly detect CRP with a limit of detection of 0.01 ng mL-1 and quantitative analysis ability. sers 13-17 C-reactive protein Homo sapiens 62-65 29648566-4 2018 The proposed SERS-based lateral flow assay can rapidly detect CRP with a limit of detection of 0.01 ng mL-1 and quantitative analysis ability. sers 13-17 L1 cell adhesion molecule Mus musculus 103-107 29600849-4 2018 The SERS spectra of fac- and mer-Ir(ppy)3, recorded at 633 nm excitation, display distinct ring breathing mode features because the total symmetric vibrational bands were enhanced. sers 4-8 FA complementation group C Homo sapiens 20-23 29595245-6 2018 So by this smart design, a SERS platform was fabricated on the basis of the stimuli-responsive DNA microcapsule to detect miRNA 155 from 1 fM to 10 nM with a detection limit of 0.67 fM. sers 27-31 microRNA 155 Homo sapiens 122-131 29389871-4 2018 This study developed a simple surface-enhanced Raman spectroscopic (SERS) method for on-site screening of tetracycline residue in milk and water. sers 68-72 Weaning weight-maternal milk Bos taurus 130-134 29750159-6 2018 SERS mapping analysis was carried out considering each representative band of the aptamer-thrombin complex (centered at 822, 1140, and 1558 cm-1) and then combining them in order to acquire a comprehensive and unambiguous measure of the target. sers 0-4 coagulation factor II, thrombin Homo sapiens 90-98 29594714-0 2018 Aptamer based determination of Pb(II) by SERS and by exploiting the reduction of HAuCl4 by H2O2 as catalyzed by graphene oxide nanoribbons. sers 41-45 submaxillary gland androgen regulated protein 3B Homo sapiens 31-37 29594714-5 2018 The SERS signal increases linearly in the 0.002-0.075 mumol L-1 Pb(II) concentration range, and the detection limit is 0.7 nmol L-1. sers 4-8 submaxillary gland androgen regulated protein 3B Homo sapiens 64-70 29556349-0 2018 Surface Enhanced Raman Spectroscopy (SERS) for the Multiplex Detection of Braf, Kras, and Pik3ca Mutations in Plasma of Colorectal Cancer Patients. sers 37-41 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 74-78 29556349-0 2018 Surface Enhanced Raman Spectroscopy (SERS) for the Multiplex Detection of Braf, Kras, and Pik3ca Mutations in Plasma of Colorectal Cancer Patients. sers 37-41 KRAS proto-oncogene, GTPase Homo sapiens 80-84 29556349-0 2018 Surface Enhanced Raman Spectroscopy (SERS) for the Multiplex Detection of Braf, Kras, and Pik3ca Mutations in Plasma of Colorectal Cancer Patients. sers 37-41 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 90-96 29556349-6 2018 To demonstrate the applicability of this process on real samples, the PCR-SERS method was applied on blood plasma taken from 49 colorectal cancer patients to detect six mutations located at the BRAF, KRAS, and PIK3CA genes. sers 74-78 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 194-198 29556349-6 2018 To demonstrate the applicability of this process on real samples, the PCR-SERS method was applied on blood plasma taken from 49 colorectal cancer patients to detect six mutations located at the BRAF, KRAS, and PIK3CA genes. sers 74-78 KRAS proto-oncogene, GTPase Homo sapiens 200-204 29556349-6 2018 To demonstrate the applicability of this process on real samples, the PCR-SERS method was applied on blood plasma taken from 49 colorectal cancer patients to detect six mutations located at the BRAF, KRAS, and PIK3CA genes. sers 74-78 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 210-216 29411598-6 2018 Then, the SERS nanoprobes were wrapped in a final silica shell and functionalized with monoclonal anti-ZIKV NS1 antibodies. sers 10-14 influenza virus NS1A binding protein Homo sapiens 108-111 33418791-5 2018 The optimized SERS nanoparticles (i.e., MBA3-AgNPR-rBSA4-FA2) can be utilized for CTC detection in blood samples with high sensitivity and specificity, and the LOD (i.e., limit of detection) reaches to five cells per milliliter. sers 14-18 FA complementation group B Homo sapiens 57-60 29445833-9 2018 The detection limit of the SERS-based LFAS for cardiac troponin I was 0.09 ng/mL, lowered by nearly 50 times compared with visual results, and could be further lowered by optimization. sers 27-31 troponin I3, cardiac type Homo sapiens 47-65 28843197-3 2018 Herein, we report a ratiometric surface-enhanced Raman scattering (SERS) aptasensor by employing aptamer-modified Au@Ag core-shell nanoparticles (Au@Ag NPs) as highly functional sensing probes, allowing for ultrasensitive detection of Hg2+. sers 67-71 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 235-238 28843197-6 2018 As a result, the Rox labels are away from the Au@Ag NP SERS substrate while Cy3 labels are close to it. sers 55-59 MAX network transcriptional repressor Homo sapiens 17-20 29068113-2 2018 Experiments with NaF, NaCl, NaBr, and NaI salts indicate that the Raman shifts of the Au-X- SERS bands correlate with the bond strength of the corresponding covalent interaction. sers 92-96 C-X-C motif chemokine ligand 8 Homo sapiens 17-20 29449902-0 2018 SERS-fluorescence bimodal nanoprobes for in vitro imaging of fatty acid responsive receptor GPR120. sers 0-4 free fatty acid receptor 4 Homo sapiens 92-98 29449902-3 2018 Here we report a novel surface-enhanced Raman spectroscopy (SERS)-fluorescence bimodal microscopic technique for detection and imaging of GPR120 in single living cells. sers 60-64 free fatty acid receptor 4 Homo sapiens 138-144 29449902-6 2018 Cellular distribution of GPR120 is visualized by single-cell SERS and fluorescence imaging. sers 61-65 free fatty acid receptor 4 Homo sapiens 25-31 29449902-7 2018 A dose-dependent GPR120 response to linoleic acid treatment is revealed by SERS. sers 75-79 free fatty acid receptor 4 Homo sapiens 17-23 29594367-5 2018 Under optimized condition, the visual limits of LFA are 10 ng mL-1 for NEO and 200 ng mL-1 for NOR, and with LODs down to 0.37 pg mL-1 and 0.55 pg mL-1 by using SERS. sers 161-165 L1 cell adhesion molecule Mus musculus 130-140 28880321-1 2017 We present the application of surface-enhanced Raman scattering (SERS) spectroscopy for the fast, sensitive and highly specific detection of the galectin-9 (Gal-9) protein in binding buffer (mimicking natural conditions). sers 65-69 galectin 9 Homo sapiens 145-155 29141148-3 2017 Plasmonically enhanced light-scattering properties facilitated PST-GNPs to be a superior SERS substrate with high Raman signal enhancement. sers 89-93 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 63-66 29141148-4 2017 In this context, PST-GNPs were scrutinized for the noninvasive label-free SERS live-cell spectral imaging to evaluate the fingerprint molecular details of cellular processes. sers 74-78 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 17-20 29141148-5 2017 Consequently, the inherent SERS feature of PST-GNPs enabled us to investigate the dynamic and complex nature with NP biodistrubution in tumor-bearing mice on a SERS platform that illustrated the tumor targeting nature. sers 27-31 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 43-46 29141148-5 2017 Consequently, the inherent SERS feature of PST-GNPs enabled us to investigate the dynamic and complex nature with NP biodistrubution in tumor-bearing mice on a SERS platform that illustrated the tumor targeting nature. sers 160-164 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 43-46 28880321-1 2017 We present the application of surface-enhanced Raman scattering (SERS) spectroscopy for the fast, sensitive and highly specific detection of the galectin-9 (Gal-9) protein in binding buffer (mimicking natural conditions). sers 65-69 galectin 9 Homo sapiens 157-162 29168853-0 2017 Electrospun flexible poly(bisphenol A carbonate) nanofibers decorated with Ag nanoparticles as effective 3D SERS substrates for trace TNT detection. sers 108-112 chromosome 16 open reading frame 82 Homo sapiens 134-137 28880321-3 2017 At fast time scales Gal-9 can be detected down to a concentration of 1.2 nM by monitoring the SERS signal of the reporter, driven by aggregation of the functionalized Au NPs tags, induced by Gal-9 recognition. sers 94-98 galectin 9 Homo sapiens 20-25 28880321-3 2017 At fast time scales Gal-9 can be detected down to a concentration of 1.2 nM by monitoring the SERS signal of the reporter, driven by aggregation of the functionalized Au NPs tags, induced by Gal-9 recognition. sers 94-98 galectin 9 Homo sapiens 191-196 28852782-1 2017 An ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay based on diatom biosilica with integrated gold nanoparticles (AuNPs) for the detection of interleukin 8 (IL-8) in blood plasma has been developed. sers 53-57 C-X-C motif chemokine ligand 8 Homo sapiens 161-174 28852782-1 2017 An ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay based on diatom biosilica with integrated gold nanoparticles (AuNPs) for the detection of interleukin 8 (IL-8) in blood plasma has been developed. sers 53-57 C-X-C motif chemokine ligand 8 Homo sapiens 176-180 28852782-3 2017 The SERS immune tags ware fabricated by functionalizing 70-nm Au nanoparticles with DTNB (i.e., 5,5"-dithiobis(2-nitrobenzoic acid)), which acted as a Raman reporter molecule, as well as the specific antibodies. sers 4-8 dystrobrevin beta Homo sapiens 84-88 28852782-8 2017 To the best of our knowledge, this is the first report on the recognition of IL-8 in human samples using a SERS-based method. sers 107-111 C-X-C motif chemokine ligand 8 Homo sapiens 77-81 28852782-11 2017 This SERS immunoassay also exhibits high biological specificity for the detection of IL-8 antigens. sers 5-9 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 28852782-13 2017 Graphical Abstract The SERS-based immunoassay based on naturally generated photonic biosilica for the detection of interleukin 8 (IL-8) in human plasma samples. sers 23-27 C-X-C motif chemokine ligand 8 Homo sapiens 115-128 28852782-13 2017 Graphical Abstract The SERS-based immunoassay based on naturally generated photonic biosilica for the detection of interleukin 8 (IL-8) in human plasma samples. sers 23-27 C-X-C motif chemokine ligand 8 Homo sapiens 130-134 28985679-1 2017 In this study, we report the crystallinity effects of submicrometer titanium dioxide (TiO2) nanotube (TNT) incorporated with silver (Ag) nanoparticles (NPs) on surface-enhanced Raman scattering (SERS) sensitivity. sers 195-199 chromosome 16 open reading frame 82 Homo sapiens 102-105 28985679-2 2017 Furthermore, we demonstrate the SERS behaviors dependent on the plasmonic-photonic interference coupling (P-PIC) in the TNT-AgNP nanoarchitectures. sers 32-36 peptidylprolyl isomerase C Homo sapiens 64-111 28985679-2 2017 Furthermore, we demonstrate the SERS behaviors dependent on the plasmonic-photonic interference coupling (P-PIC) in the TNT-AgNP nanoarchitectures. sers 32-36 chromosome 16 open reading frame 82 Homo sapiens 120-123 28796314-8 2017 To confirm these findings, a SERS nanoprobe was conjugated with a specific tumour targeting marker, EGFR (Epidermal Growth Factor Receptor), a well known targeted agent for Human Fibrosarcoma (HT1080). sers 29-33 epidermal growth factor receptor Homo sapiens 100-104 30965810-6 2017 Raman spectroscopy of the chromophore Eosin Y adsorbed onto the metallodielectric films showed that they are excellent SERS substrates at NIR excitation with an enhancement factor of ~9.3 x 103. sers 119-123 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 138-141 28875696-6 2017 Here, we exploit the high sensitivity of surface-enhanced Raman spectroscopy (SERS) in a multiplexed assay that can distinguish between Zika and dengue nonstructural protein 1 (NS1) biomarkers. sers 78-82 influenza virus NS1A binding protein Homo sapiens 177-180 28875696-7 2017 SERS-encoded gold nanostars were conjugated to specific antibodies for both diseases and used in a dipstick immunoassay, which exhibited 15-fold and 7-fold lower detection limits for Zika NS1 and dengue NS1, respectively. sers 0-4 influenza virus NS1A binding protein Homo sapiens 188-191 28875696-7 2017 SERS-encoded gold nanostars were conjugated to specific antibodies for both diseases and used in a dipstick immunoassay, which exhibited 15-fold and 7-fold lower detection limits for Zika NS1 and dengue NS1, respectively. sers 0-4 influenza virus NS1A binding protein Homo sapiens 203-206 28796314-8 2017 To confirm these findings, a SERS nanoprobe was conjugated with a specific tumour targeting marker, EGFR (Epidermal Growth Factor Receptor), a well known targeted agent for Human Fibrosarcoma (HT1080). sers 29-33 epidermal growth factor receptor Homo sapiens 106-138 28825473-7 2017 The SERS signal of Raman nanotag was lost upon NCL capturing via modified DNA aptamers on nanoprobe, which further helped to verify the specificity of nanoprobe. sers 4-8 nucleolin Homo sapiens 47-50 28905956-0 2017 Poly-cytosine-mediated nanotags for SERS detection of Hg2. sers 36-40 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 54-57 28905956-2 2017 Herein, we have developed poly-cytosine (polyC)-mediated surface-enhanced Raman scattering (SERS) nanotags as a sensor system for rapid, selective, and sensitive detection of Hg2+ based on thymidine-Hg2+-thymidine (T-Hg2+-T) coordination and polyC-mediated Raman activity. sers 92-96 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 175-178 28905956-2 2017 Herein, we have developed poly-cytosine (polyC)-mediated surface-enhanced Raman scattering (SERS) nanotags as a sensor system for rapid, selective, and sensitive detection of Hg2+ based on thymidine-Hg2+-thymidine (T-Hg2+-T) coordination and polyC-mediated Raman activity. sers 92-96 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 199-202 28905956-2 2017 Herein, we have developed poly-cytosine (polyC)-mediated surface-enhanced Raman scattering (SERS) nanotags as a sensor system for rapid, selective, and sensitive detection of Hg2+ based on thymidine-Hg2+-thymidine (T-Hg2+-T) coordination and polyC-mediated Raman activity. sers 92-96 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 199-202 28905956-3 2017 The SERS nanotags exploit the mismatched T-T base pairs to capture Hg2+ form T-Hg2+-T bridges, which induce the aggregation of nanotags giving rise to the drastic amplification in the SERS signals. sers 4-8 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 67-70 28905956-3 2017 The SERS nanotags exploit the mismatched T-T base pairs to capture Hg2+ form T-Hg2+-T bridges, which induce the aggregation of nanotags giving rise to the drastic amplification in the SERS signals. sers 4-8 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 79-82 28905956-3 2017 The SERS nanotags exploit the mismatched T-T base pairs to capture Hg2+ form T-Hg2+-T bridges, which induce the aggregation of nanotags giving rise to the drastic amplification in the SERS signals. sers 184-188 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 67-70 28905956-3 2017 The SERS nanotags exploit the mismatched T-T base pairs to capture Hg2+ form T-Hg2+-T bridges, which induce the aggregation of nanotags giving rise to the drastic amplification in the SERS signals. sers 184-188 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 79-82 28905956-5 2017 As a result, the polyC-mediated SERS nanotags show an excellent response for Hg2+ in the concentration range from 0.1 to 1000 nM and good selectivity over other metal ions. sers 32-36 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 77-80 29072486-1 2017 AIM: Here, a multiplex surface-enhanced Raman scattering (SERS) based assay for simultaneous quantitation of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) was developed. sers 58-62 CEA cell adhesion molecule 3 Homo sapiens 109-133 29072486-1 2017 AIM: Here, a multiplex surface-enhanced Raman scattering (SERS) based assay for simultaneous quantitation of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) was developed. sers 58-62 CEA cell adhesion molecule 3 Homo sapiens 135-138 29072486-1 2017 AIM: Here, a multiplex surface-enhanced Raman scattering (SERS) based assay for simultaneous quantitation of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) was developed. sers 58-62 alpha fetoprotein Homo sapiens 144-161 29072486-1 2017 AIM: Here, a multiplex surface-enhanced Raman scattering (SERS) based assay for simultaneous quantitation of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) was developed. sers 58-62 alpha fetoprotein Homo sapiens 163-166 29072486-4 2017 RESULTS: The SERS-based technique showed a wide linear range from 0.5 to 100 ng/ml and detection limits were 0.41 and 0.35 ng/ml for CEA and AFP in phosphate-buffered saline buffer, respectively. sers 13-17 CEA cell adhesion molecule 3 Homo sapiens 133-136 29072486-4 2017 RESULTS: The SERS-based technique showed a wide linear range from 0.5 to 100 ng/ml and detection limits were 0.41 and 0.35 ng/ml for CEA and AFP in phosphate-buffered saline buffer, respectively. sers 13-17 alpha fetoprotein Homo sapiens 141-144 28825473-8 2017 For proof of concept, NCL protein was specifically extracted from different cell lines by aptamers modified SERS active nanoprobe. sers 108-112 nucleolin Homo sapiens 22-25 28770990-5 2017 Herein, we present a novel concept for the early diagnosis of HCC based on the combination of Raman frequency shift and intensity change, and developed surface-enhanced Raman scattering (SERS)-based immunochips via AFP-L3%. sers 187-191 alpha fetoprotein Homo sapiens 215-218 28816042-2 2017 For alkaline phosphatase (ALP) monitoring in medical treatment, a rapid, reliable surface-enhanced Raman scattering (SERS) test kit is designed based on a "hot spots" amplification strategy. sers 117-121 alkaline phosphatase, placental Homo sapiens 4-24 28770990-10 2017 The most important advantage of the proposed method is the combination of AFP-L3% and frequency shifts of SERS, which exhibits excellent reproducibility and high accuracy, and significantly simplifies the conventional detection procedure of AFP-L3%. sers 106-110 alpha fetoprotein Homo sapiens 241-244 28649960-6 2017 The robust free-standing AuNPs-decorated mat which calcined at 500 C (500/AuNPs-F) exhibited high SERS activity toward cationic (methylene blue, MB) and anionic (methyl orange, MO) dyes in single and binary systems with a detection range from tens of nM to a few hundred muM. sers 99-103 latexin Homo sapiens 272-275 29046858-6 2017 In addition, the surface-enhanced Raman scattering (SERS) activity of the PSMA@Ag photonic crystal films was evaluated by detecting the signal from Raman probe molecules, 4-aminothiophenol (4-ATP). sers 52-56 folate hydrolase 1 Homo sapiens 74-78 29147108-0 2017 MUC1 Aptamer Targeted SERS Nanoprobes. sers 22-26 mucin 1, transmembrane Mus musculus 0-4 29147108-4 2017 We developed a strategy to functionalize SERS NPs with DNA aptamers, which target Mucin1 (MUC1) in human breast cancer (BC). sers 41-45 mucin 1, cell surface associated Homo sapiens 82-88 29147108-4 2017 We developed a strategy to functionalize SERS NPs with DNA aptamers, which target Mucin1 (MUC1) in human breast cancer (BC). sers 41-45 mucin 1, cell surface associated Homo sapiens 90-94 29147108-6 2017 In order to test their in vivo targeting capability, we co-injected MUC1-targeted SERS NPs, and as controls non-targeted and blocked MUC1-targeted SERS NPs in BC xenograft mouse models. sers 82-86 mucin 1, transmembrane Mus musculus 68-72 29147108-6 2017 In order to test their in vivo targeting capability, we co-injected MUC1-targeted SERS NPs, and as controls non-targeted and blocked MUC1-targeted SERS NPs in BC xenograft mouse models. sers 147-151 mucin 1, transmembrane Mus musculus 133-137 29147108-8 2017 The results showed that the targeted SERS NPs home to the tumors via active targeting of MUC1, with low levels of passive targeting. sers 37-41 mucin 1, transmembrane Mus musculus 89-93 28292735-0 2017 A novel SERS-based magnetic aptasensor for prostate specific antigen assay with high sensitivity. sers 8-12 kallikrein related peptidase 3 Homo sapiens 43-68 28292735-2 2017 In this report, we present a novel aptamer-based surface-enhanced Raman scattering (SERS) sensor that employs magnetic nanoparticles (MNPs) core-Au nanoparticles (AuNPs) satellite assemblies to detect PSA. sers 84-88 kallikrein related peptidase 3 Homo sapiens 201-204 28292735-6 2017 It was found that the corresponding SERS signals from the supernatant were in direct correlation to PSA concentrations over a wide range and the limit of detection (LOD) was as low as 5.0pg/mL. sers 36-40 kallikrein related peptidase 3 Homo sapiens 100-103 29046858-7 2017 The PSMA@Ag photonic crystal films exhibited a high SERS effect, a low detection limit of up to 10-8 for 4-ATP, good uniformity, and reproducibility. sers 52-56 folate hydrolase 1 Homo sapiens 4-8 28667313-5 2017 Using SERS nanoparticles that target HER2 and CD44 in breast cancer cells, we demonstrate labeling of fixed cells with high specificity that correlates well with fluorescent labels. sers 6-10 erb-b2 receptor tyrosine kinase 2 Homo sapiens 37-41 28782050-2 2017 By utilizing multiplexed surface-enhanced Raman scattering (SERS) imaging, enabled by the narrow peak widths of Raman signatures, we simultaneously targeted immune checkpoint receptor programmed death ligand 1 (PDL1) and the epidermal growth factor receptor (EGFR) overexpressed in TNBC cells. sers 60-64 CD274 molecule Homo sapiens 184-209 28782050-2 2017 By utilizing multiplexed surface-enhanced Raman scattering (SERS) imaging, enabled by the narrow peak widths of Raman signatures, we simultaneously targeted immune checkpoint receptor programmed death ligand 1 (PDL1) and the epidermal growth factor receptor (EGFR) overexpressed in TNBC cells. sers 60-64 CD274 molecule Homo sapiens 211-215 28782050-2 2017 By utilizing multiplexed surface-enhanced Raman scattering (SERS) imaging, enabled by the narrow peak widths of Raman signatures, we simultaneously targeted immune checkpoint receptor programmed death ligand 1 (PDL1) and the epidermal growth factor receptor (EGFR) overexpressed in TNBC cells. sers 60-64 epidermal growth factor receptor Homo sapiens 225-257 28782050-2 2017 By utilizing multiplexed surface-enhanced Raman scattering (SERS) imaging, enabled by the narrow peak widths of Raman signatures, we simultaneously targeted immune checkpoint receptor programmed death ligand 1 (PDL1) and the epidermal growth factor receptor (EGFR) overexpressed in TNBC cells. sers 60-64 epidermal growth factor receptor Homo sapiens 259-263 29060498-6 2017 Our work here intends to define an optimal PCA-SVM (Principal Component Analysis-Support Vector Machine) with Multilayer Layer Perceptron (MLP) kernel model to distinct between positive and negative NS1 infected samples from salivary SERS spectra, which, to the best of our knowledge, has never been explored. sers 234-238 influenza virus NS1A binding protein Homo sapiens 199-202 28737921-2 2017 In this article, we report the use of a simple mass production technology based on Blu-ray disc manufacturing technology to prepare large area SERS substrates (~40 mm2) with a high degree of homogeneity (+-7% variation in Raman signal) and enhancement factor of ~6 x 106. sers 143-147 zinc finger MYND-type containing 10 Homo sapiens 83-86 28750529-6 2017 Microscopic and spectroscopic characterizations of the CNF-AuNPs SERS substrate show that the CNFs enhance the stability of both the AuNP clusters and the SERS activity. sers 65-69 NPHS1 adhesion molecule, nephrin Homo sapiens 55-58 28750529-6 2017 Microscopic and spectroscopic characterizations of the CNF-AuNPs SERS substrate show that the CNFs enhance the stability of both the AuNP clusters and the SERS activity. sers 155-159 NPHS1 adhesion molecule, nephrin Homo sapiens 55-58 28750529-7 2017 The CNF-AuNPs SERS substrate is significantly more stable and sensitive than the SERS substrate fabricated by directly depositing the AuNP suspension on a smooth glass surface. sers 14-18 NPHS1 adhesion molecule, nephrin Homo sapiens 4-7 28375605-5 2017 We have demonstrated a specific 2D-distribution SERS spectral analytical approach to analyze DA-hDAT interaction. sers 48-52 solute carrier family 6 member 3 Homo sapiens 96-100 28684733-1 2017 In this study, surface enhanced Raman spectroscopy (SERS) in combination with multiplexed polymerase chain reaction (PCR) was utilized to detect mutations of exons 19 and 21 of the epidermal growth factor receptor (EGFR) gene. sers 52-56 epidermal growth factor receptor Homo sapiens 181-213 28684733-1 2017 In this study, surface enhanced Raman spectroscopy (SERS) in combination with multiplexed polymerase chain reaction (PCR) was utilized to detect mutations of exons 19 and 21 of the epidermal growth factor receptor (EGFR) gene. sers 52-56 epidermal growth factor receptor Homo sapiens 215-219 28684733-5 2017 Then, this PCR-SERS method was used on the plasma of 48 patients with non-small cell lung cancer (NSCLC) to detect EGFR mutations. sers 15-19 epidermal growth factor receptor Homo sapiens 115-119 28684733-10 2017 Our study indicates that PCR-SERS is an effective, noninvasive, and economical method for the detection and monitoring of EGFR mutations in the plasma of patients with NSCLC. sers 29-33 epidermal growth factor receptor Homo sapiens 122-126 28667313-5 2017 Using SERS nanoparticles that target HER2 and CD44 in breast cancer cells, we demonstrate labeling of fixed cells with high specificity that correlates well with fluorescent labels. sers 6-10 CD44 molecule (Indian blood group) Homo sapiens 46-50 28549217-4 2017 The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG. We then assembled glucose oxidase (GOx) and lactate oxidase (LOx) onto AuNPs@MIL-101 to form AuNPs@MIL-101@GOx and AuNPs@MIL-101@LOx integrative nanozymes for in vitro detection of glucose and lactate via SERS. sers 206-210 lysyl oxidase Rattus norvegicus 318-333 28549217-4 2017 The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG. We then assembled glucose oxidase (GOx) and lactate oxidase (LOx) onto AuNPs@MIL-101 to form AuNPs@MIL-101@GOx and AuNPs@MIL-101@LOx integrative nanozymes for in vitro detection of glucose and lactate via SERS. sers 206-210 lysyl oxidase Rattus norvegicus 335-338 28549217-4 2017 The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG. We then assembled glucose oxidase (GOx) and lactate oxidase (LOx) onto AuNPs@MIL-101 to form AuNPs@MIL-101@GOx and AuNPs@MIL-101@LOx integrative nanozymes for in vitro detection of glucose and lactate via SERS. sers 206-210 lysyl oxidase Rattus norvegicus 403-406 28549217-4 2017 The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG. We then assembled glucose oxidase (GOx) and lactate oxidase (LOx) onto AuNPs@MIL-101 to form AuNPs@MIL-101@GOx and AuNPs@MIL-101@LOx integrative nanozymes for in vitro detection of glucose and lactate via SERS. sers 479-483 lysyl oxidase Rattus norvegicus 318-333 28549217-4 2017 The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG. We then assembled glucose oxidase (GOx) and lactate oxidase (LOx) onto AuNPs@MIL-101 to form AuNPs@MIL-101@GOx and AuNPs@MIL-101@LOx integrative nanozymes for in vitro detection of glucose and lactate via SERS. sers 479-483 lysyl oxidase Rattus norvegicus 335-338 28549217-4 2017 The obtained AuNPs@MIL-101 nanozymes acted as peroxidase mimics to oxidize Raman-inactive reporter leucomalachite green into the active malachite green (MG) with hydrogen peroxide and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG. We then assembled glucose oxidase (GOx) and lactate oxidase (LOx) onto AuNPs@MIL-101 to form AuNPs@MIL-101@GOx and AuNPs@MIL-101@LOx integrative nanozymes for in vitro detection of glucose and lactate via SERS. sers 479-483 lysyl oxidase Rattus norvegicus 403-406 28534412-5 2017 In diagnostic aspect, SNP@PST was revealed to be a superior SERS substrate with multiscale Raman signal enhancement contributed by homogeneous hot-spot distribution. sers 60-64 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 26-29 28365452-4 2017 Thus, here we performed a study to use the Gd-Au NPs for detection and imaging of a widely recognized human cancer biomarker, epidermal growth factor receptor (EGFR), in individual human cancer cells with surface-enhanced Raman scattering (SERS). sers 240-244 epidermal growth factor receptor Homo sapiens 126-158 28365452-4 2017 Thus, here we performed a study to use the Gd-Au NPs for detection and imaging of a widely recognized human cancer biomarker, epidermal growth factor receptor (EGFR), in individual human cancer cells with surface-enhanced Raman scattering (SERS). sers 240-244 epidermal growth factor receptor Homo sapiens 160-164 28365452-5 2017 The Gd-Au NPs were sequentially conjugated with a monoclonal antibody recognizing EGFR and a Raman reporter molecule, 4-meraptobenzoic acid (MBA), to generate a characteristic SERS signal at 1075cm-1. sers 176-180 epidermal growth factor receptor Homo sapiens 82-86 28365452-6 2017 By spatially mapping the SERS intensity at 1075cm-1, cellular distribution of EGFR and its relocalization on the plasma membrane were measured in situ. sers 25-29 epidermal growth factor receptor Homo sapiens 78-82 28773010-0 2017 Synthesis of Au NP@MoS2 Quantum Dots Core@Shell Nanocomposites for SERS Bio-Analysis and Label-Free Bio-Imaging. sers 67-71 mago homolog, exon junction complex core component Mus musculus 19-23 28365452-7 2017 In addition, the EGFR expression levels in three human cancer cell lines (S18, A431 and A549) were measured using this SERS probe, which were consistent with the comparable measurements using immunoblotting and immunofluorescence. sers 119-123 epidermal growth factor receptor Homo sapiens 17-21 28365452-8 2017 Our SERS results show that functionalized Gd-Au NPs successfully targeted EGFR molecules in three human cancer cell lines and monitored changes in single cell EGFR distribution in situ, demonstrating its potential to study cell activity under physiological conditions. sers 4-8 epidermal growth factor receptor Homo sapiens 74-78 28773010-3 2017 The prepared Au NP@MoS2 QDs reveal high surface enhanced Raman scattering (SERS) performance regarding sensitivity as well as the satisfactory SERS reproducibility and stability. sers 75-79 mago homolog, exon junction complex core component Mus musculus 19-23 28773010-3 2017 The prepared Au NP@MoS2 QDs reveal high surface enhanced Raman scattering (SERS) performance regarding sensitivity as well as the satisfactory SERS reproducibility and stability. sers 143-147 mago homolog, exon junction complex core component Mus musculus 19-23 28773010-5 2017 Furthermore, the near-infrared SERS detection based on Au NP@MoS2 QDs in living cells is achieved with distinct Raman signals which are clearly assigned to the various cellular components. sers 31-35 mago homolog, exon junction complex core component Mus musculus 61-65 28773010-6 2017 Meanwhile, the distinguishable SERS images are acquired from the 4T1 cells with the incubation of Au NP@MoS2 QDs. sers 31-35 mago homolog, exon junction complex core component Mus musculus 104-108 28773010-7 2017 Consequently, the straightforward strategy of using Au NP@MoS2 QDs exhibits great potential as a superior SERS substrate for chemical and biological detection as well as bio-imaging. sers 106-110 mago homolog, exon junction complex core component Mus musculus 58-62 28371262-2 2017 In this study, a gold-upconversion-nanoparticle (Au-UCNP) pyramid based on aptamers is fabricated to simultaneously detect thrombin and prostate-specific antigen (PSA) using surface-enhanced Raman scattering (SERS) and fluorescence, respectively. sers 209-213 coagulation factor II, thrombin Homo sapiens 123-131 28371262-3 2017 The higher the concentration of thrombin, the lower the intensity of SERS. sers 69-73 coagulation factor II, thrombin Homo sapiens 32-40 28225598-5 2017 Therefore, the intensity of SERS signal from Rox labels increases while that from Cy5 labels decreases. sers 28-32 MAX network transcriptional repressor Homo sapiens 45-48 28256644-2 2017 Here we have developed a rapid method based on surface-enhanced Raman spectroscopy (SERS) with Au colloids and an isotope-labeled nicotine (d4-nicotine) internal standard for the measurement/quantification of samples which contain 10s of mg mL-1 nicotine in a complex viscous matrix. sers 84-88 L1 cell adhesion molecule Mus musculus 241-245 28256644-5 2017 This is possible because the nicotine concentration in the e-liquids (<=24 mg mL-1) is of several orders of magnitude above the working range of the SERS measurement. sers 152-156 L1 cell adhesion molecule Mus musculus 81-85 28225598-6 2017 The results show that the ratio between the Raman intensities of Rox labels and Cy5 labels is well linear with the ATP concentrations in the range from 0.1 to 100 nM, and the limit of detection reaches 20 pM, which is much lower than that of other methods for ATP detection and is also lower than that of SERS aptasensor for ATP detection. sers 305-309 MAX network transcriptional repressor Homo sapiens 65-68 28155925-4 2017 By using alkaline phosphatase (ALP) to dephosphorylate its substrate, 2-phospho-l-ascorbic acid trisodium salt (AAP), to form vitamin C, silver ions could be reduced into silver atoms and coated on the surface of the AuNPs; a greatly enhanced SERS signal was then obtained. sers 243-247 alkaline phosphatase, placental Homo sapiens 9-29 28156092-4 2017 The proposed Au/ZnONRs/G SERS sensor showed an enhancement factor of 2.3 x 106 via rhodamine 6G Raman probe and excellent reproducibility (relative standard deviation of <10%) via Raman mapping of a SERS active area with a square of 100 x 100 mum2. sers 25-29 trafficking protein particle complex subunit 1 Homo sapiens 246-250 32263931-5 2017 Here we report a stable, reproducible, and facile SERS-based readout method to detect an important tumor marker, carcinoembryonic antigen (CEA). sers 50-54 CEA cell adhesion molecule 3 Homo sapiens 113-137 32263931-5 2017 Here we report a stable, reproducible, and facile SERS-based readout method to detect an important tumor marker, carcinoembryonic antigen (CEA). sers 50-54 CEA cell adhesion molecule 3 Homo sapiens 139-142 28169391-3 2017 Herein, we propose a zwitterionic copolymer, namely poly(glycidyl methacrylate-co-sulfobetaine methacrylate) (poly(GMA-co-SBMA)), for the surface modification of SERS substrates, which were fabricated and characterized spectroscopically. sers 162-166 androgen receptor Homo sapiens 122-126 28193002-4 2017 In the present study, organic cyanide (4-mercaptobenzonitrile, MBN) was utilized for the first time in developing a facile nanoprobe based on surface-enhanced Raman scattering (SERS) for quantitative detection of hemeproteins (oxy-Hb) and trivalent iron (Fe3+) ions. sers 177-181 proteinase 3 Homo sapiens 63-66 28155925-4 2017 By using alkaline phosphatase (ALP) to dephosphorylate its substrate, 2-phospho-l-ascorbic acid trisodium salt (AAP), to form vitamin C, silver ions could be reduced into silver atoms and coated on the surface of the AuNPs; a greatly enhanced SERS signal was then obtained. sers 243-247 alkaline phosphatase, placental Homo sapiens 31-34 28155925-4 2017 By using alkaline phosphatase (ALP) to dephosphorylate its substrate, 2-phospho-l-ascorbic acid trisodium salt (AAP), to form vitamin C, silver ions could be reduced into silver atoms and coated on the surface of the AuNPs; a greatly enhanced SERS signal was then obtained. sers 243-247 serpin family F member 2 Homo sapiens 112-115 28155925-7 2017 Identical results could be obtained by using the newly proposed SERS immunoassay for the clinical detection of AFP in serum samples of patients to those clinically obtained by chemiluminescence immunoassays, demonstrating the potential applications of the developed method in clinical diagnosis. sers 64-68 alpha fetoprotein Homo sapiens 111-114 27796455-0 2017 Aptamer-based surface-enhanced Raman scattering (SERS) sensor for thrombin based on supramolecular recognition, oriented assembly, and local field coupling. sers 49-53 coagulation factor II, thrombin Homo sapiens 66-74 28054556-3 2017 In this report, we characterized Syk structural changes according to its phosphorylation/activation status by Surface Enhanced Raman Spectroscopy (SERS). sers 147-151 spleen associated tyrosine kinase Homo sapiens 33-36 28054556-5 2017 Syk forms were then analysed by SERS that was carried out in liquid condition on a lithographically designed gold nanocylinders array. sers 32-36 spleen associated tyrosine kinase Homo sapiens 0-3 28054556-6 2017 Our study demonstrated that SERS signatures of the two Syk forms were drastically distinct, indicating structural modifications related to their phosphorylation status. sers 28-32 spleen associated tyrosine kinase Homo sapiens 55-58 28054556-7 2017 By comparison with the atomic structure of the unphosphorylated Syk, the SERS peak assignments of the phosphorylated Syk nearest gold nanostructures revealed a differential interaction with the gold surface. sers 73-77 spleen associated tyrosine kinase Homo sapiens 117-120 27796455-1 2017 A supramolecular recognition and oriented assembly system was developed on chip for the highly selective surface-enhanced Raman scattering (SERS) detection of thrombin by means of the aptamer-based SERS tag method. sers 140-144 coagulation factor II, thrombin Homo sapiens 159-167 27796455-1 2017 A supramolecular recognition and oriented assembly system was developed on chip for the highly selective surface-enhanced Raman scattering (SERS) detection of thrombin by means of the aptamer-based SERS tag method. sers 198-202 coagulation factor II, thrombin Homo sapiens 159-167 27796455-4 2017 After the recognition between the aptamer and thrombin, a bridge is built between the SERS tag (4-mercaptobenzoic acid marked Ag nanoparticle) and the fixed thrombin based on the activation of the carboxylic group of 4-mercaptobenzoic acid. sers 86-90 coagulation factor II, thrombin Homo sapiens 46-54 27796455-4 2017 After the recognition between the aptamer and thrombin, a bridge is built between the SERS tag (4-mercaptobenzoic acid marked Ag nanoparticle) and the fixed thrombin based on the activation of the carboxylic group of 4-mercaptobenzoic acid. sers 86-90 coagulation factor II, thrombin Homo sapiens 157-165 27796455-5 2017 Thus, the quantitative detection of thrombin can be achieved based on the SERS intensity of the immobilized SERS tags. sers 74-78 coagulation factor II, thrombin Homo sapiens 36-44 27796455-5 2017 Thus, the quantitative detection of thrombin can be achieved based on the SERS intensity of the immobilized SERS tags. sers 108-112 coagulation factor II, thrombin Homo sapiens 36-44 27796455-8 2017 Graphical Abstract Illustration of the aptamer-based SERS sensor for thrombin detection. sers 53-57 coagulation factor II, thrombin Homo sapiens 69-77 27973744-0 2017 Aptamer-Based SERS Detection of Lysozyme on a Food-Handling Surface. sers 14-18 lysozyme Homo sapiens 32-40 27736725-0 2017 SERS characterization of neuropeptide Y and its C-terminal fragments deposited onto colloidal gold nanoparticle surface. sers 0-4 neuropeptide Y Homo sapiens 25-39 27973744-3 2017 In this paper, an aptamer highly specific to egg white lysozyme was coupled to dendritic silver nanoparticles in order to perform surface enhanced Raman spectroscopy (SERS). sers 167-171 lysozyme Homo sapiens 55-63 27973744-6 2017 Principal component analysis shows a significant change in SERS spectra when lysozyme was present, suggesting the successful capture of lysozyme by the aptamer. sers 59-63 lysozyme Homo sapiens 77-85 27973744-6 2017 Principal component analysis shows a significant change in SERS spectra when lysozyme was present, suggesting the successful capture of lysozyme by the aptamer. sers 59-63 lysozyme Homo sapiens 136-144 30460305-5 2017 The prepared SERS probe GNRs containing 4-mercaptobenzoic acid as a Raman reporter to generate SERS signals were used for detection of intracellular adhesion molecule-1 (ICAM-1) in macrophages after treatment with LPS for varying lengths of time. sers 13-17 intercellular adhesion molecule 1 Mus musculus 135-168 30460305-5 2017 The prepared SERS probe GNRs containing 4-mercaptobenzoic acid as a Raman reporter to generate SERS signals were used for detection of intracellular adhesion molecule-1 (ICAM-1) in macrophages after treatment with LPS for varying lengths of time. sers 13-17 intercellular adhesion molecule 1 Mus musculus 170-176 30460305-5 2017 The prepared SERS probe GNRs containing 4-mercaptobenzoic acid as a Raman reporter to generate SERS signals were used for detection of intracellular adhesion molecule-1 (ICAM-1) in macrophages after treatment with LPS for varying lengths of time. sers 95-99 intercellular adhesion molecule 1 Mus musculus 135-168 30460305-5 2017 The prepared SERS probe GNRs containing 4-mercaptobenzoic acid as a Raman reporter to generate SERS signals were used for detection of intracellular adhesion molecule-1 (ICAM-1) in macrophages after treatment with LPS for varying lengths of time. sers 95-99 intercellular adhesion molecule 1 Mus musculus 170-176 30460305-6 2017 Our results show that SERS probe GNRs could detect significant differences in the expression of ICAM-1 molecules in LPS-treated macrophages compared to those in untreated macrophages after only 1 h of LPS treatment. sers 22-26 intercellular adhesion molecule 1 Mus musculus 96-102 27797525-1 2016 Tip-enhanced Raman spectroscopy (TERS) combines the ability of scanning probe microscopy (SPM) to resolve atomic-scale surface features with the single-molecule chemical sensitivity of surface-enhanced Raman spectroscopy (SERS). sers 222-226 TOR signaling pathway regulator Homo sapiens 0-3 27934116-2 2016 Herein, we present a toehold-mediated, DNA displacement-based, SERS sensor for detecting point mutations in the BIGH3 gene associated with the most common corneal dystrophies (CDs) in a clinical setting. sers 63-67 transforming growth factor beta induced Homo sapiens 112-117 27344521-7 2016 For example the SERS spectra recorded with the CZA solution at pH~2 shows blue shift for different bands compared to its NRS window e.g. 406 to 450cm(-1), 616 to 632cm(-1), 1332 to 1343cm(-1) etc. sers 16-20 polyhomeotic homolog 2 Homo sapiens 63-67 27209579-7 2016 The SERS spectra showed distinct peaks for tags corresponding to three typical sepsis-specific biomarkers for diagnostics with the limit of detection values of 27 pM, 103 pM, and 78 pM for C-reactive protein (CRP), procalcitonin (PCT), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), respectively. sers 4-8 C-reactive protein Homo sapiens 189-207 27209579-7 2016 The SERS spectra showed distinct peaks for tags corresponding to three typical sepsis-specific biomarkers for diagnostics with the limit of detection values of 27 pM, 103 pM, and 78 pM for C-reactive protein (CRP), procalcitonin (PCT), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), respectively. sers 4-8 C-reactive protein Homo sapiens 209-212 27208477-2 2016 When hCG was present in the peptide probe solution, the AgNPs did not aggregate and it had strong catalytic effect on the gold nanoparticle reaction with a strong resonance Rayleigh scattering (RRS) peak at 370nm and a strong surface enhanced Raman scattering (SERS) peak at 1615cm(-1) in the presence of molecular probe of Victoria blue 4R (VB4R). sers 261-265 hypertrichosis 2 (generalised, congenital) Homo sapiens 5-8 27731990-3 2016 Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman scattering (SERS) assay for the quantification of c-MYC in real blood samples. sers 96-100 MYC proto-oncogene, bHLH transcription factor Homo sapiens 134-139 27208477-5 2016 And the SERS intensity at 1615cm(-1) increased linearly with the hCG concentration in the range of 0.05-20ng/mL, with a linear regression equation of DeltaI1615cm-1=142C+134. sers 8-12 hypertrichosis 2 (generalised, congenital) Homo sapiens 65-68 27208477-6 2016 Based on this, two new methods of nanocatalytic SERS and RRS were proposed for the determination of trace hCG. sers 48-52 hypertrichosis 2 (generalised, congenital) Homo sapiens 106-109 27731990-5 2016 Peptide/c-MYC recognition events translate into measurable alterations of the SERS spectra associated with a molecular reorientation of the transducer, in agreement with the surface selection rules. sers 78-82 MYC proto-oncogene, bHLH transcription factor Homo sapiens 8-13 27518716-1 2016 Glucose oxidase (GOx) possessing a Raman-active chromophore (flavin adenine dinucleotide) is used as a signal reporter for constructing a highly specific "turn off" surface-enhanced Raman scattering (SERS) sensor for glucose. sers 200-204 hydroxyacid oxidase 1 Homo sapiens 0-15 28451123-2 2016 To address those needs we report surface-enhanced Raman scattering (SERS) based optical imaging for prostate cancer using a combination of live cell Raman microscopy, optimally engineered SERS tags and a urea-based small-molecule inhibitor of prostate-specific membrane antigen (PSMA) as a targeting moiety. sers 68-72 folate hydrolase 1 Homo sapiens 243-277 28451123-2 2016 To address those needs we report surface-enhanced Raman scattering (SERS) based optical imaging for prostate cancer using a combination of live cell Raman microscopy, optimally engineered SERS tags and a urea-based small-molecule inhibitor of prostate-specific membrane antigen (PSMA) as a targeting moiety. sers 68-72 folate hydrolase 1 Homo sapiens 279-283 28451123-3 2016 We develop gold nanostar based SERS agents that offer ultrahigh binding affinity to PSMA with nearly four orders of magnitude lower IC50 values in relation to existing clinical imaging agents. sers 31-35 folate hydrolase 1 Homo sapiens 84-88 28451123-5 2016 Using Raman microscopy to analyze phenotypically similar prostate cancer cell lines differing only in PSMA expression, we demonstrate facile, site-selective recognition using as low as 20 pM of the SERS agent for imaging, opening the door for spectroscopic detection of prostate and other PSMA-expressing tumors in vivo. sers 198-202 folate hydrolase 1 Homo sapiens 102-106 28451123-5 2016 Using Raman microscopy to analyze phenotypically similar prostate cancer cell lines differing only in PSMA expression, we demonstrate facile, site-selective recognition using as low as 20 pM of the SERS agent for imaging, opening the door for spectroscopic detection of prostate and other PSMA-expressing tumors in vivo. sers 198-202 folate hydrolase 1 Homo sapiens 289-293 27603514-10 2016 The optimized ELISA-like assay shows sensitivities comparable to those of commercial plates for the detection of miRNA222 (LOD: 485 pM), paving the way for the application of the developed protocol on metal-dielectric/semiconductor nanostructures for ultrasensitive SERS biosensing applications. sers 266-270 microRNA 222 Homo sapiens 113-121 27518716-4 2016 As a result, the SERS intensity of GOx on the chip decreases along with the concentration of glucose. sers 17-21 hydroxyacid oxidase 1 Homo sapiens 35-38 27518716-5 2016 This glucose SERS sensor exhibits excellent selectivity based on the specific GOx/glucose catalysis reaction and high sensitivity to 1.0 muM. sers 13-17 hydroxyacid oxidase 1 Homo sapiens 78-81 27518716-1 2016 Glucose oxidase (GOx) possessing a Raman-active chromophore (flavin adenine dinucleotide) is used as a signal reporter for constructing a highly specific "turn off" surface-enhanced Raman scattering (SERS) sensor for glucose. sers 200-204 hydroxyacid oxidase 1 Homo sapiens 17-20 27518716-9 2016 Graphical abstract Glucose oxidase is used as a Raman signal reporter for constructing a highly specific glucose surface-enhanced Raman scattering (SERS) sensor. sers 148-152 hydroxyacid oxidase 1 Homo sapiens 19-34 27149109-4 2016 The working principle of the proposed SERS tag is based on the immobilization of HbA1c by cyclic boronate ester formation between glycosyl residues of HbA1c and boronic acid groups of magnetic polymethacrylate microspheres and the binding of p-aminothiophenol (PATP)-functionalized Ag nanoparticles (Ag NPs) carrying another boronic acid ligand via cyclic boronate ester formation via unused glycosyl groups of bound HbA1c. sers 38-42 hemoglobin subunit alpha 1 Homo sapiens 81-85 27509304-3 2016 By targeting stem cell surface markers SSEA-5 and TRA-1-60 individually or simultaneously, these SERS assays were able to identify as few as 1 stem cell in 10(6) cells, a sensitivity (0.0001%) which was ~2000 to 15,000-fold higher than that of flow cytometry assays. sers 97-101 phospholipid scramblase 4 Homo sapiens 50-55 27055173-3 2016 In this study, SERS substrates constituted by Au nanoparticles deposited on paper by a simple dipping method have been used for rapid (few minutes) analysis of diluted human serum spiked with different concentrations of methotrexate, MTX. sers 15-19 metaxin 1 Homo sapiens 234-237 27711470-8 2016 The SERS technique enables us to detect this radical cation at very low concentrations of ABTS (~2 muM). sers 4-8 latexin Homo sapiens 99-102 29345891-4 2016 Herein, we described a new strategy for non-invasive TMPRSS2-ERG detection in patient urinary samples by coupling of isothermal reverse transcription-recombinase polymerization amplification (RT-RPA) to amplify TMPRSS2-ERG transcripts and surface-enhanced Raman scattering (SERS) to directly detect the amplicons. sers 274-278 transmembrane serine protease 2 Homo sapiens 53-60 29345891-4 2016 Herein, we described a new strategy for non-invasive TMPRSS2-ERG detection in patient urinary samples by coupling of isothermal reverse transcription-recombinase polymerization amplification (RT-RPA) to amplify TMPRSS2-ERG transcripts and surface-enhanced Raman scattering (SERS) to directly detect the amplicons. sers 274-278 ETS transcription factor ERG Homo sapiens 61-64 29345891-4 2016 Herein, we described a new strategy for non-invasive TMPRSS2-ERG detection in patient urinary samples by coupling of isothermal reverse transcription-recombinase polymerization amplification (RT-RPA) to amplify TMPRSS2-ERG transcripts and surface-enhanced Raman scattering (SERS) to directly detect the amplicons. sers 274-278 transmembrane serine protease 2 Homo sapiens 211-218 27452074-7 2016 The individual CLMP shows excellent surface-enhanced Raman scattering (SERS) performance with high enhancement factor (EF) and good reproducibility as it integrates the SERS enhancement effects of individual Au nanoplate and the nanogaps formed by the uniform and hierarchical structures. sers 71-75 CXADR like membrane protein Homo sapiens 15-19 27452074-7 2016 The individual CLMP shows excellent surface-enhanced Raman scattering (SERS) performance with high enhancement factor (EF) and good reproducibility as it integrates the SERS enhancement effects of individual Au nanoplate and the nanogaps formed by the uniform and hierarchical structures. sers 169-173 CXADR like membrane protein Homo sapiens 15-19 27086022-0 2016 Gold-sputtered Blu-ray discs: simple and inexpensive SERS substrates for sensitive detection of melamine. sers 53-57 zinc finger MYND-type containing 10 Homo sapiens 15-18 27086022-3 2016 Here, we describe the novel use of gold-sputtered Blu-ray disc surfaces as SERS substrates. sers 75-79 zinc finger MYND-type containing 10 Homo sapiens 50-53 27086022-7 2016 Gold-sputtered Blu-ray discs thus offer an excellent alternative to more exotic gold SERS substrates prepared by advanced, time-consuming and expensive methods. sers 85-89 zinc finger MYND-type containing 10 Homo sapiens 15-18 27028517-4 2016 Combined with the efficient ctDNA recognition capacity of our designed triple-helix molecular switch and RNase HII enzyme-assisted amplification, the T-rich DNA-mediated SERS enhancement of SWNTs could read out a content of KRAS G12DM as low as 0.3 fM, with a detection of 5.0 muL of sample volume, which has potential for point-of-care testing in clinical analysis. sers 170-174 KRAS proto-oncogene, GTPase Homo sapiens 224-228 26838436-0 2016 Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection. sers 43-47 albumin Homo sapiens 5-18 27049934-4 2016 An efficient SERS nanoprobe has been constructed using gold nanoparticles as SERS substrate, and the TPE-In as the Raman reporter, which conjugated with a specific peptide substrate, Cys-Ser-Lys-Leu-Gln-OH, well-known for the recognition of prostate-specific antigen (PSA). sers 13-17 kallikrein related peptidase 3 Homo sapiens 241-272 27049934-5 2016 The designated nanoprobe TPE-In-PSA@Au acted as SERS "ON/OFF" probe in peace with the vicinity of PSA protease, which distinctly recognizes PSA expression with a limit of detection of 0.5 ng in SERS platform. sers 48-52 kallikrein related peptidase 3 Homo sapiens 32-35 27049934-5 2016 The designated nanoprobe TPE-In-PSA@Au acted as SERS "ON/OFF" probe in peace with the vicinity of PSA protease, which distinctly recognizes PSA expression with a limit of detection of 0.5 ng in SERS platform. sers 48-52 kallikrein related peptidase 3 Homo sapiens 98-101 27049934-5 2016 The designated nanoprobe TPE-In-PSA@Au acted as SERS "ON/OFF" probe in peace with the vicinity of PSA protease, which distinctly recognizes PSA expression with a limit of detection of 0.5 ng in SERS platform. sers 48-52 kallikrein related peptidase 3 Homo sapiens 98-101 27049934-5 2016 The designated nanoprobe TPE-In-PSA@Au acted as SERS "ON/OFF" probe in peace with the vicinity of PSA protease, which distinctly recognizes PSA expression with a limit of detection of 0.5 ng in SERS platform. sers 194-198 kallikrein related peptidase 3 Homo sapiens 32-35 27049934-5 2016 The designated nanoprobe TPE-In-PSA@Au acted as SERS "ON/OFF" probe in peace with the vicinity of PSA protease, which distinctly recognizes PSA expression with a limit of detection of 0.5 ng in SERS platform. sers 194-198 kallikrein related peptidase 3 Homo sapiens 98-101 27049934-5 2016 The designated nanoprobe TPE-In-PSA@Au acted as SERS "ON/OFF" probe in peace with the vicinity of PSA protease, which distinctly recognizes PSA expression with a limit of detection of 0.5 ng in SERS platform. sers 194-198 kallikrein related peptidase 3 Homo sapiens 98-101 27049934-6 2016 Furthermore, TPE-In-PSA@Au nanoprobe was efficiently recognized the overexpressed PSA in human LNCaP cells, which can be visualized through SERS spectral analysis and SERS mapping. sers 140-144 kallikrein related peptidase 3 Homo sapiens 20-23 27049934-6 2016 Furthermore, TPE-In-PSA@Au nanoprobe was efficiently recognized the overexpressed PSA in human LNCaP cells, which can be visualized through SERS spectral analysis and SERS mapping. sers 140-144 kallikrein related peptidase 3 Homo sapiens 82-85 27049934-6 2016 Furthermore, TPE-In-PSA@Au nanoprobe was efficiently recognized the overexpressed PSA in human LNCaP cells, which can be visualized through SERS spectral analysis and SERS mapping. sers 167-171 kallikrein related peptidase 3 Homo sapiens 20-23 27049934-6 2016 Furthermore, TPE-In-PSA@Au nanoprobe was efficiently recognized the overexpressed PSA in human LNCaP cells, which can be visualized through SERS spectral analysis and SERS mapping. sers 167-171 kallikrein related peptidase 3 Homo sapiens 82-85 26656628-10 2016 In this article, the authors reported their technique of direct surface enhanced Raman spectroscopy (SERS) detection using magnetic core gold nanoparticles functionalized with recombinant human erythropoietin-specific antibody. sers 101-105 erythropoietin Homo sapiens 194-208 26838436-3 2016 Herein, we developed novel SERS probes, based on BSA (Bull Serum Albumin) coated gold-silver core-shell nanorods modified with Raman reporter 5,5-dithiobis 2-nitrobenzoic acid (DTNB) (Au@AgNRs@BSA@Anti-MICA), for in vitro cancer cell detection. sers 27-31 albumin Homo sapiens 59-72 26838436-3 2016 Herein, we developed novel SERS probes, based on BSA (Bull Serum Albumin) coated gold-silver core-shell nanorods modified with Raman reporter 5,5-dithiobis 2-nitrobenzoic acid (DTNB) (Au@AgNRs@BSA@Anti-MICA), for in vitro cancer cell detection. sers 27-31 MHC class I polypeptide-related sequence A Homo sapiens 202-206 26872242-1 2016 Directional plasmon excitation and surface enhanced Raman scattering (SERS) emission were demonstrated for 1D and 2D gold nanostructure arrays deposited on a flat gold layer. sers 70-74 leiomodin 1 Homo sapiens 107-116 26879372-0 2016 Wash-free magnetic immunoassay of the PSA cancer marker using SERS and droplet microfluidics. sers 62-66 kallikrein related peptidase 3 Homo sapiens 38-41 26879372-1 2016 We report a novel wash-free magnetic immunoassay technique for prostate-specific antigen (PSA) that uses a surface-enhanced Raman scattering (SERS)-based microdroplet sensor. sers 142-146 kallikrein related peptidase 3 Homo sapiens 63-94 26879372-3 2016 The presence of PSA targets leads more SERS tags to immunocomplex in one droplet so that fewer SERS tags remain in another supernatant solution droplet. sers 39-43 kallikrein related peptidase 3 Homo sapiens 16-19 26879372-3 2016 The presence of PSA targets leads more SERS tags to immunocomplex in one droplet so that fewer SERS tags remain in another supernatant solution droplet. sers 95-99 kallikrein related peptidase 3 Homo sapiens 16-19 26879372-4 2016 Thus, SERS signal measurement enables the quantitative evaluation of PSA markers. sers 6-10 kallikrein related peptidase 3 Homo sapiens 69-72 26808062-1 2016 In this present work, a rapid and simple method to detect carcinoembryonic antigen (CEA) was developed by using surface-enhanced Raman spectroscopy (SERS) coupled with antibody-modified Au and gamma-Fe2O3@Au nanoparticles. sers 149-153 CEA cell adhesion molecule 3 Homo sapiens 58-82 26808062-1 2016 In this present work, a rapid and simple method to detect carcinoembryonic antigen (CEA) was developed by using surface-enhanced Raman spectroscopy (SERS) coupled with antibody-modified Au and gamma-Fe2O3@Au nanoparticles. sers 149-153 CEA cell adhesion molecule 3 Homo sapiens 84-87 26808062-4 2016 The selective and sensitive detection of CEA could be achieved by SERS after magnetic separation. sers 66-70 CEA cell adhesion molecule 3 Homo sapiens 41-44 26731464-2 2016 Here, a surface-enhanced Raman scattering (SERS) frequency-shift immunoassay is developed for detection of liver cancer biomarkers alpha-fetoprotein and Glypican-3 down to subpicomolar concentrations in saline solution. sers 43-47 alpha fetoprotein Homo sapiens 131-148 26688120-4 2016 Based on the change of SERS signal through in situ regulation the nanoarchitecture of the colloid, a sensitive and selective strategy for Pb(2+) measurement was developed with a linear range from 5nM to 4muM as well as a low detection limit of 1nM. sers 23-27 latexin Homo sapiens 204-207 26814978-0 2016 A High-Sensitivity and Low-Power Theranostic Nanosystem for Cell SERS Imaging and Selectively Photothermal Therapy Using Anti-EGFR-Conjugated Reduced Graphene Oxide/Mesoporous Silica/AuNPs Nanosheets. sers 65-69 epidermal growth factor receptor Homo sapiens 126-130 26701141-7 2016 High narrow nanogap-containing Au@Au core-shell SERS tags (GCTs) were prepared via the functionalization of hyaluronic acid (HA) on GCNPs, which recognized the CD44 receptor, a tumor-associated surface biomarker. sers 48-52 CD44 molecule (Indian blood group) Homo sapiens 160-164 26849392-1 2016 An improved label-free approach for highly sensitive and selective detection of 3,3",4,4"-tetrachlorobiphenyl (PCB-77), a type of polychlorinated biphenyl, via surface-enhanced Raman spectroscopy (SERS) using DNA aptamer-modified Ag-nanorod arrays as the effective substrate is reported. sers 197-201 pyruvate carboxylase Homo sapiens 111-114 26849392-5 2016 Moreover, it is found that the DNA aptamer-based Ag-NR arrays can be more responsive with a lower and optimal density of the DNA molecules modified on the substrate surface, and the best sensitivity for detection of PCB-77 can be achieved with the lower detection limit approaching 3.3 x 10(-8) M. This work therefore demonstrates that the design of aptamer-modified Ag-NRs can be used as a practically promising SERS substrate for label-free trace detection of persistent organic pollutants (POPs) in the environment. sers 413-417 pyruvate carboxylase Homo sapiens 216-219 26731464-2 2016 Here, a surface-enhanced Raman scattering (SERS) frequency-shift immunoassay is developed for detection of liver cancer biomarkers alpha-fetoprotein and Glypican-3 down to subpicomolar concentrations in saline solution. sers 43-47 glypican 3 Homo sapiens 153-163 32260603-3 2016 The particles selectively aggregate upon interaction with CTB, causing an increase in the measured SERS signal. sers 99-103 phosphate cytidylyltransferase 1B, choline Homo sapiens 58-61 26339871-6 2015 The mercapto aptamers captured the targets in the mixed zone and were immobilized to the SERS detection zone via S-Ag bonds so as to further improve both the SERS sensitivity and selectivity of PCB77. sers 89-93 S-antigen visual arrestin Homo sapiens 113-117 26231778-1 2016 We presented a computational study on para-substituted Benzenethiol (x-BT, x=H, F, Cl, Br, OH, SH, SeH, NH2, CH3) derivatives interacting with gold cluster for chemical effects related to surface-enhanced Raman spectroscopy (SERS). sers 225-229 epoxide hydrolase 2 Homo sapiens 99-102 26554759-2 2015 Tip-enhanced Raman spectroscopy (TERS) is a combination of surface-enhanced Raman spectroscopy (SERS) and scanning probe microscopy (SPM), which can provide high-resolution topographic and spectral information simultaneously below the diffraction limit of light. sers 96-100 TOR signaling pathway regulator Homo sapiens 0-3 26716456-7 2015 RESULTS: Isoalantolactone enhanced the radiosensitivity of UMSCC-10A cells; the sensitivity enhanced ratios (SERs) were 1.44 and 1.63, respectively, for 2.5 and 5 muM. sers 109-113 latexin Homo sapiens 163-166 26339871-6 2015 The mercapto aptamers captured the targets in the mixed zone and were immobilized to the SERS detection zone via S-Ag bonds so as to further improve both the SERS sensitivity and selectivity of PCB77. sers 158-162 S-antigen visual arrestin Homo sapiens 113-117 25478906-4 2015 The substrates consisting of the SiO2@Au@Ag@CD NPs were employed for SERS detection of polychlorinated biphenyls (PCBs) including PCB-3, PCB-29 and PCB-77. sers 69-73 pyruvate carboxylase Homo sapiens 114-117 26346634-3 2015 Here we suggest a novel label-free approach based on the surface-enhanced Raman spectroscopy (SERS) to monitor the redox state and conformation of cytochrome c in the electron transport chain in living mitochondria. sers 94-98 cytochrome c, somatic Homo sapiens 147-159 26346634-4 2015 We demonstrate that SERS spectra of living mitochondria placed on hierarchically structured silver-ring substrates provide exclusive information about cytochrome c behavior under modulation of inner mitochondrial membrane potential, proton gradient and the activity of ATP-synthetase. sers 20-24 cytochrome c, somatic Homo sapiens 151-163 25478906-4 2015 The substrates consisting of the SiO2@Au@Ag@CD NPs were employed for SERS detection of polychlorinated biphenyls (PCBs) including PCB-3, PCB-29 and PCB-77. sers 69-73 pyruvate carboxylase Homo sapiens 130-133 25478906-4 2015 The substrates consisting of the SiO2@Au@Ag@CD NPs were employed for SERS detection of polychlorinated biphenyls (PCBs) including PCB-3, PCB-29 and PCB-77. sers 69-73 pyruvate carboxylase Homo sapiens 130-133 25478906-5 2015 The SERS detection sensitivity was significantly improved due to enrichment of more PCB molecules captured by beta-CD on the substrate surface, as confirmed by the appearance of the new Raman bands which are attributed to the complexes between beta-CD and PCBs according to the theoretical simulation. sers 4-8 pyruvate carboxylase Homo sapiens 84-87 25841120-2 2015 Herein, intact antibodies (IgG) and Fab fragments conjugated onto gold nanostar were used to fabricate two kinds of immunosensors for measurement of their SERS signals. sers 155-159 FA complementation group B Homo sapiens 36-39 25801955-5 2015 Further conjugation of these nanotag with monoclonal antibodies specific to over expressed receptors, EGFR and p16/Ki-67 in cervical cancer cell, HeLa showed prominent SERS mapping intensity and selectivity towards cell surface and nucleus. sers 168-172 cyclin dependent kinase inhibitor 2A Homo sapiens 111-114 25841120-3 2015 Using CA125 as the antigen and Rhodamine-6G (R6G)-conjugated immunogolds, a SERS immunosensor was self-assembled by antigen-antibody interaction. sers 76-80 mucin 16, cell surface associated Homo sapiens 6-11 25841120-4 2015 The results showed that the SERS signal from the Fab immunosensor was 2.4 times higher than that of the IgG immunosensor. sers 28-32 FA complementation group B Homo sapiens 49-52 25841120-6 2015 For application, based on the Fab immunosensor, a SERS-compatible microfluidic system was designed for multiplex assays to overcome the drawbacks of conventional assays. sers 50-54 FA complementation group B Homo sapiens 30-33 25703723-1 2015 A novel label-free method for the in-situ monitoring of protein tyrosine nitration (PTN) was explored based on surface-enhanced Raman spectroscopy (SERS). sers 148-152 pleiotrophin Homo sapiens 84-87 25703723-3 2015 The distinction of the SERS spectra between non-nitrated peptides and nitrated peptides was obtained by directly comparing SERS bands at 330-400cm(-1), allowing the rapid identification of PTN. sers 23-27 pleiotrophin Homo sapiens 189-192 25703723-3 2015 The distinction of the SERS spectra between non-nitrated peptides and nitrated peptides was obtained by directly comparing SERS bands at 330-400cm(-1), allowing the rapid identification of PTN. sers 123-127 pleiotrophin Homo sapiens 189-192 26405519-5 2015 In the developed SERS assay, both the assay chip and surface-enhanced Raman spectroscopy (SERS) tags are functionalized with monoclonal antibodies against CA15-3, CA27-29 and CEA, respectively. sers 17-21 mucin 1, cell surface associated Homo sapiens 155-161 25941778-7 2015 Our results demonstrated that co-culture with ATII cells or incubation with TGF-beta could induce the differentiation of LR-MSCs as confirmed by SERS analysis, a method that is capable of noninvasive characterization of and distinction between subtypes of LR-MSCs during differentiation. sers 145-149 transforming growth factor beta 1 Homo sapiens 76-84 26405519-5 2015 In the developed SERS assay, both the assay chip and surface-enhanced Raman spectroscopy (SERS) tags are functionalized with monoclonal antibodies against CA15-3, CA27-29 and CEA, respectively. sers 17-21 CEA cell adhesion molecule 3 Homo sapiens 175-178 26405519-5 2015 In the developed SERS assay, both the assay chip and surface-enhanced Raman spectroscopy (SERS) tags are functionalized with monoclonal antibodies against CA15-3, CA27-29 and CEA, respectively. sers 90-94 mucin 1, cell surface associated Homo sapiens 155-161 26405519-5 2015 In the developed SERS assay, both the assay chip and surface-enhanced Raman spectroscopy (SERS) tags are functionalized with monoclonal antibodies against CA15-3, CA27-29 and CEA, respectively. sers 90-94 CEA cell adhesion molecule 3 Homo sapiens 175-178 26027901-5 2015 Reported result shows that nanoplatform can be used for SERS "fingerprint" identification of beta-amyloid and tau protein after magnetic separation even at 100 fg/mL level. sers 56-60 microtubule associated protein tau Homo sapiens 110-113 25643599-0 2015 Ultrasensitive SERS detection of VEGF based on a self-assembled Ag ornamented-AU pyramid superstructure. sers 15-19 vascular endothelial growth factor A Homo sapiens 33-37 25643599-2 2015 Under optimized conditions, the SERS signal was negatively related to VEGF concentration over the range 0.01-1.0 fM and the limit of detection (LOD) was as low as 22.6 aM. sers 32-36 vascular endothelial growth factor A Homo sapiens 70-74 26114030-1 2015 A surface enhanced Raman spectroscopy (SERS) based platform was developed for sensitive multiplexed detection of matrix metalloproteinases (MMP) (MMP-2 and MMP-7) with low limit of detection and high specificity. sers 39-43 matrix metallopeptidase 2 Homo sapiens 146-151 25877040-8 2015 Furthermore, the SERS intensities of 4-methylbenzenethiol (4-MTP) molecules on TOH Au NCs are also higher than those on spherical Au NCs of comparable size due to sharp extremities. sers 17-21 metallothionein 1B Homo sapiens 61-64 25899553-1 2015 A simple and efficient self-approach strategy was used to apply ultrasensitivity and self-revive ZnO-Ag hybrid surface-enhanced Raman scattering (SERS) sensors for the highly sensitive and selective detection of explosive TNT in both solution and vapour conditions. sers 146-150 chromosome 16 open reading frame 82 Homo sapiens 222-225 25899553-4 2015 Compared with other pure Ag-based SERS sensors, this ZnO-Ag hybrid SERS sensor could rapidly self-revive SERS-activity by simple UV light irradiation and could retain stable SERS sensitivity for one month when used for TNT detection. sers 34-38 chromosome 16 open reading frame 82 Homo sapiens 219-222 25899553-4 2015 Compared with other pure Ag-based SERS sensors, this ZnO-Ag hybrid SERS sensor could rapidly self-revive SERS-activity by simple UV light irradiation and could retain stable SERS sensitivity for one month when used for TNT detection. sers 67-71 chromosome 16 open reading frame 82 Homo sapiens 219-222 25899553-4 2015 Compared with other pure Ag-based SERS sensors, this ZnO-Ag hybrid SERS sensor could rapidly self-revive SERS-activity by simple UV light irradiation and could retain stable SERS sensitivity for one month when used for TNT detection. sers 67-71 chromosome 16 open reading frame 82 Homo sapiens 219-222 25899553-4 2015 Compared with other pure Ag-based SERS sensors, this ZnO-Ag hybrid SERS sensor could rapidly self-revive SERS-activity by simple UV light irradiation and could retain stable SERS sensitivity for one month when used for TNT detection. sers 67-71 chromosome 16 open reading frame 82 Homo sapiens 219-222 26114030-1 2015 A surface enhanced Raman spectroscopy (SERS) based platform was developed for sensitive multiplexed detection of matrix metalloproteinases (MMP) (MMP-2 and MMP-7) with low limit of detection and high specificity. sers 39-43 matrix metallopeptidase 7 Homo sapiens 156-161 25802895-7 2015 Larger gold nanoparticles may better satisfy the theoretical restraints for SERS enhancement at NIR/IR wavelengths compared to smaller nanoparticles. sers 76-80 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 96-99 25766032-1 2015 An ultrasensitive surface-enhanced Raman spectroscopy (SERS) sensor based on rolling-circle amplification (RCA)-increased "hot-spot" was developed for the detection of thrombin. sers 55-59 coagulation factor II, thrombin Homo sapiens 168-176 25938206-5 2015 Then, a protocol is described to prepare multicore-SERS-labels (MSLs) by aggregating gold nanoparticles, coating with a reporter molecule and a thin silver shell to further boost enhancement, encapsulating with a stable silica layer, and functionalizing by epithelial cell adhesion molecule (EpCAM) antibodies. sers 51-55 epithelial cell adhesion molecule Homo sapiens 257-290 25938206-5 2015 Then, a protocol is described to prepare multicore-SERS-labels (MSLs) by aggregating gold nanoparticles, coating with a reporter molecule and a thin silver shell to further boost enhancement, encapsulating with a stable silica layer, and functionalizing by epithelial cell adhesion molecule (EpCAM) antibodies. sers 51-55 epithelial cell adhesion molecule Homo sapiens 292-297 25766032-6 2015 This SERS method achieved the detection of thrombin in the range from 1.0x10(-12) to 1.0x10(-8) M and a detection limit of 4.2x10(-13) M, and showed good performance in real serum samples. sers 5-9 coagulation factor II, thrombin Homo sapiens 43-51 25497982-1 2015 A sensitive protocol for surface enhanced Raman spectroscopy (SERS) detection of thrombin is designed with R6G-Ag NPs as a signal tag by combining DNAzyme assistant DNA recycling and rolling circle amplification (RCA). sers 62-66 coagulation factor II, thrombin Homo sapiens 81-89 25497982-6 2015 Because of the cascade signal amplification, these newly designed protocols provides a sensitive SERS detection of thrombin down to the femolar level (2.3fM) with a linear range of 5 orders of magnitude (from 10(-14) to 10(-9)M) and have high selectivity toward its target protein. sers 97-101 coagulation factor II, thrombin Homo sapiens 115-123 25461184-4 2015 Through this strategy, a novel and facile "turn-on" SERS biosensor for trypsin and thrombin based on enzymatic cleavage activity is established with sensitivity, selectivity and simplicity as AuNPs and peptides are easily accessible. sers 52-56 coagulation factor II, thrombin Homo sapiens 83-91 24859273-5 2014 In this work, we report using SERS imaging to assess the inhibitory effect of cetuximab on EGFR expressed on cancer cells. sers 30-34 epidermal growth factor receptor Homo sapiens 91-95 23963680-6 2014 As a proof-of-concept for targeted multiplex detection, initially we carried out the sensing of epidermal growth factor receptor (EGFR) biomarker in oral squamous carcinoma cell lysate using three different SERS nanotags. sers 207-211 epidermal growth factor receptor Homo sapiens 96-128 23963680-6 2014 As a proof-of-concept for targeted multiplex detection, initially we carried out the sensing of epidermal growth factor receptor (EGFR) biomarker in oral squamous carcinoma cell lysate using three different SERS nanotags. sers 207-211 epidermal growth factor receptor Homo sapiens 130-134 25216462-0 2015 Based on SERS conformational studies of ginsenoside Rb1 and its metabolites before and after combined with human serum albumin. sers 9-13 RB transcriptional corepressor 1 Homo sapiens 52-55 25216462-4 2015 SERS spectra of ginsenoside Rb1, Rd, Rg3 and CK were obtained from a colloidal silver surface on a self-assembled SERS substrate, the most enhanced modes were those with certain motions perpendicular to the metal surface, such as C24C25 stretch and CH out-of-plane bending from alkyl chain. sers 0-4 RB transcriptional corepressor 1 Homo sapiens 28-31 25216462-4 2015 SERS spectra of ginsenoside Rb1, Rd, Rg3 and CK were obtained from a colloidal silver surface on a self-assembled SERS substrate, the most enhanced modes were those with certain motions perpendicular to the metal surface, such as C24C25 stretch and CH out-of-plane bending from alkyl chain. sers 114-118 RB transcriptional corepressor 1 Homo sapiens 28-31 25495142-6 2015 After capped with crystal violet (CV), polyethylene glycol, and EGFR mutation specific antibody, the AuNC-EGFR had excellent surface-enhanced Raman scattering (SERS) activity and EGFR mutation targeted recognition capability in lung cancer cells. sers 160-164 epidermal growth factor receptor Homo sapiens 106-110 25495142-6 2015 After capped with crystal violet (CV), polyethylene glycol, and EGFR mutation specific antibody, the AuNC-EGFR had excellent surface-enhanced Raman scattering (SERS) activity and EGFR mutation targeted recognition capability in lung cancer cells. sers 160-164 epidermal growth factor receptor Homo sapiens 106-110 25495142-9 2015 Furthermore, SERS was preclinically utilized to test EGFR mutation status in MPE samples from 35 patients with lung adenocarcinoma. sers 13-17 epidermal growth factor receptor Homo sapiens 53-57 25495142-11 2015 SERS measurement based on sea-urchin-like AuNC was an efficient method for EGFR mutation detection in MPE, and it might show great potential in applications such as predicting gene typing of clinical lung cancer in the near future. sers 0-4 epidermal growth factor receptor Homo sapiens 75-79 25313473-0 2015 Neuropeptide Y and its C-terminal fragments acting on Y2 receptor: Raman and SERS spectroscopy studies. sers 77-81 neuropeptide Y Homo sapiens 0-14 25046405-0 2015 Wide-field multiplexed imaging of EGFR-targeted cancers using topical application of NIR SERS nanoprobes. sers 89-93 epidermal growth factor receptor Homo sapiens 34-38 25243249-5 2014 The detection limit of a prostate-specific antigen in this immunosystem was as low as 2 x 10(-14) g ml(-1), attributing to the significant electromagnetic coupling effect generated between the densely packed silver NCs and the SERS-active silicon nanowire arrays. sers 227-231 kallikrein related peptidase 3 Homo sapiens 25-50 24859273-6 2014 From SERS mapping images using silica-encapsulated gold nanotags, the localized spatial distribution of EGFR that was not inhibited by cetuximab could be determined. sers 5-9 epidermal growth factor receptor Homo sapiens 104-108 24859273-7 2014 Furthermore, EGFR expression could be accurately quantified through the statistical analysis of surface-enhanced Raman scattering (SERS) spectral data. sers 131-135 epidermal growth factor receptor Homo sapiens 13-17 25157565-3 2014 Here, to fill this deficiency, we conducted detailed analyses of the SERS of pyridine adsorbed through N-Ag bonding on the homonuclear diatomic metal cluster Ag2 and heteronuclear diatomic metal clusters of AuAg and CuAg, as well as the involved charge transfer under an intracluster excitation, based on calculations using time-dependent density functional theory with a short-time approximation for the Raman cross-section. sers 69-73 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 158-161 25192978-4 2014 This seems to be feasible since single APol-trapped MPs can fit into gaps between noble metal NPs, or in other gap-containing SERS substrates, whereby the enhancement of Raman scattering signal may be sufficient for SM sensitivity. sers 126-130 apolipoprotein L1 Homo sapiens 39-43 25179113-4 2014 Functionalized nanoprobes demonstrated the ability to map the expression of vascular adhesion molecule-1 (VCAM-1) in human coronary artery endothelial (HCAE) cells, indicating that microwave fabrication presents a viable and rapid approach to SERS nanoprobe construction. sers 243-247 vascular cell adhesion molecule 1 Homo sapiens 76-104 25179113-4 2014 Functionalized nanoprobes demonstrated the ability to map the expression of vascular adhesion molecule-1 (VCAM-1) in human coronary artery endothelial (HCAE) cells, indicating that microwave fabrication presents a viable and rapid approach to SERS nanoprobe construction. sers 243-247 vascular cell adhesion molecule 1 Homo sapiens 106-112 25192978-5 2014 The goal of the present study is to give a proof of concept of SERS with APol-stabilized MPs, using bacteriorhodopsin (BR) as a model. sers 63-67 apolipoprotein L1 Homo sapiens 73-77 25192978-8 2014 SERS spectra resemble non-SERS spectra of a dried sample of BR/APol complexes. sers 0-4 apolipoprotein L1 Homo sapiens 63-67 25192978-8 2014 SERS spectra resemble non-SERS spectra of a dried sample of BR/APol complexes. sers 26-30 apolipoprotein L1 Homo sapiens 63-67 24460907-7 2014 We present here the development and application of SERS-based mRNA detection and quantification using the expression of the TWD1 gene in wild type and both mutant alleles. sers 51-55 FKBP-type peptidyl-prolyl cis-trans isomerase family protein Arabidopsis thaliana 124-128 25059138-5 2014 SERS experiments were carried out on Ag NP-decorated filter paper combined with "dynamic SERS" (D-SERS) due to its high detection sensitivity. sers 0-4 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 89-94 25052032-4 2014 With the addition of free zearalenone, the competitive immune reaction between free zearalenone and zearalenone-bovine serum albumin was initiated for binding with zearalenone antibody labeled on gold nanoparticle, resulting in the change of SERS signal intensity. sers 242-246 albumin Homo sapiens 125-132 24789330-8 2014 This approach should bring SERS closer to the real world through ink cartridges to be fixed to a pen to create plasmonic sensors at will. sers 27-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 25015184-5 2014 The created RGO/AuNP film, when serving as SERS biodetection platform, presents outstanding performances in detecting 4-aminothiophenol with an enhancement factor of approximately 5.6 x 10(5) as well as 2-thiouracil sensing with a low concentration to 1 muM. sers 43-47 latexin Homo sapiens 254-257 24776730-0 2014 Label-free selective SERS detection of PCB-77 based on DNA aptamer modified SiO2@Au core/shell nanoparticles. sers 21-25 pyruvate carboxylase Homo sapiens 39-42 25150698-2 2014 This study investigates expression, spatial distribution as well as the endocytosis of EGFR in single breast cancer cells using surface-enhanced Raman spectroscopy (SERS). sers 165-169 epidermal growth factor receptor Homo sapiens 87-91 25150698-3 2014 By incubating anti-EGFR antibody conjugated SERS nanoprobes with an EGFR-over-expressing cancer cell line, A431, EGFR localization was measured over time and found to be located primarily at the cell surface. sers 44-48 epidermal growth factor receptor Homo sapiens 19-23 25150698-3 2014 By incubating anti-EGFR antibody conjugated SERS nanoprobes with an EGFR-over-expressing cancer cell line, A431, EGFR localization was measured over time and found to be located primarily at the cell surface. sers 44-48 epidermal growth factor receptor Homo sapiens 68-72 25150698-3 2014 By incubating anti-EGFR antibody conjugated SERS nanoprobes with an EGFR-over-expressing cancer cell line, A431, EGFR localization was measured over time and found to be located primarily at the cell surface. sers 44-48 epidermal growth factor receptor Homo sapiens 68-72 25150698-4 2014 To further validate the constructed SERS probes, we applied this SERS probes to detect the EGFR expression on breast cancer cells (MDA-MB-435, MDA-MB-231) and their counterpart cell lines in which EGFR expression was down-regulated by breast cancer metastasis suppressor 1 (BRMS1). sers 36-40 epidermal growth factor receptor Homo sapiens 91-95 25150698-4 2014 To further validate the constructed SERS probes, we applied this SERS probes to detect the EGFR expression on breast cancer cells (MDA-MB-435, MDA-MB-231) and their counterpart cell lines in which EGFR expression was down-regulated by breast cancer metastasis suppressor 1 (BRMS1). sers 36-40 epidermal growth factor receptor Homo sapiens 197-201 25150698-4 2014 To further validate the constructed SERS probes, we applied this SERS probes to detect the EGFR expression on breast cancer cells (MDA-MB-435, MDA-MB-231) and their counterpart cell lines in which EGFR expression was down-regulated by breast cancer metastasis suppressor 1 (BRMS1). sers 65-69 epidermal growth factor receptor Homo sapiens 91-95 25150698-4 2014 To further validate the constructed SERS probes, we applied this SERS probes to detect the EGFR expression on breast cancer cells (MDA-MB-435, MDA-MB-231) and their counterpart cell lines in which EGFR expression was down-regulated by breast cancer metastasis suppressor 1 (BRMS1). sers 65-69 epidermal growth factor receptor Homo sapiens 197-201 25150698-5 2014 The results showed that SERS method not only confirms immunoblot data measuring EGFR levels, but also adds new insights regarding EGFR localization and internalization in living cells which is impossible in immunoblot method. sers 24-28 epidermal growth factor receptor Homo sapiens 80-84 25150698-5 2014 The results showed that SERS method not only confirms immunoblot data measuring EGFR levels, but also adds new insights regarding EGFR localization and internalization in living cells which is impossible in immunoblot method. sers 24-28 epidermal growth factor receptor Homo sapiens 130-134 24789330-2 2014 Inspired by recent advances in conductive ink pens for electronic devices on paper, we present a "pen-on-paper" approach for making surface enhanced Raman scattering (SERS) substrates. sers 167-171 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 46-49 24789330-3 2014 Through this approach, no professional training is required to create SERS arrays on paper using an ordinary fountain pen filled with plasmonic inks comprising metal nanoparticles of arbitrary shape and size. sers 70-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 118-121 24972791-3 2014 Based on SERS studies, molecular docking, molecular dynamics simulation, biochemical assays, and point mutation-based validation, we demonstrate the surface-binding mode of this molecule in two similar hydrophobic pockets in the Aurora A kinase. sers 9-13 aurora kinase A Homo sapiens 229-237 24577570-9 2014 Furthermore, the SERS spectra of label-free proteins (catalase, cytochrome C, avidin and lysozyme) from the assembled sandwich have excellent reproducibility and high quality. sers 17-21 cytochrome c, somatic Homo sapiens 64-76 32261477-5 2014 It was possible to control the number of satellites in an assembly which allowed optical parameters such as SPR maxima and the SERS intensity to be tuned. sers 127-131 sepiapterin reductase Homo sapiens 108-111 24658299-4 2014 For a SERS-based trial analysis of polychlorinated biphenyls (PCBs, a kind of global environmental hazard), the 3D SERS substrate membranes are modified with mono-6-beta-cychlodextrin to effectively capture PCB molecules. sers 6-10 pyruvate carboxylase Homo sapiens 62-65 24658299-4 2014 For a SERS-based trial analysis of polychlorinated biphenyls (PCBs, a kind of global environmental hazard), the 3D SERS substrate membranes are modified with mono-6-beta-cychlodextrin to effectively capture PCB molecules. sers 115-119 pyruvate carboxylase Homo sapiens 62-65 24418951-3 2014 In the second method (sandwich assay), the target miR-21 was captured by an miR-21 probe immobilised onto the gold slide and hybridised with a second miR-21 probe immobilised on the SERS-labeled, rod-shaped gold nanoparticles. sers 182-186 microRNA 21 Homo sapiens 50-56 24418951-7 2014 The developed SERS-based methods offer rapid, selective, sensitive and easy detection of miR-21, especially compared to conventional PCR-based methods. sers 14-18 microRNA 21 Homo sapiens 89-95 24773569-5 2014 We singled out the concentration of myoglobin as the determinant of these differences, and verified on this basis that surface-enhanced Raman scattering (SERS) spectra can only be obtained by aggregates with strong interparticle optical coupling, which are obtained at low protein concentration. sers 154-158 myoglobin Homo sapiens 36-45 24631541-0 2014 Detection and quantification of alternative splice sites in Arabidopsis genes AtDCL2 and AtPTB2 with highly sensitive surface enhanced Raman spectroscopy (SERS) and gold nanoprobes. sers 155-159 dicer-like 2 Arabidopsis thaliana 78-84 24631541-0 2014 Detection and quantification of alternative splice sites in Arabidopsis genes AtDCL2 and AtPTB2 with highly sensitive surface enhanced Raman spectroscopy (SERS) and gold nanoprobes. sers 155-159 polypyrimidine tract-binding protein 2 Arabidopsis thaliana 89-95 24418951-0 2014 SERS-based direct and sandwich assay methods for mir-21 detection. sers 0-4 microRNA 21 Homo sapiens 49-55 24418951-1 2014 In this study, two different assay methods were developed using a surface enhanced Raman scattering (SERS) label for sensitive miR-21 detection. sers 101-105 microRNA 21 Homo sapiens 127-133 24418951-2 2014 In the first method (direct assay), the miR-21 probe was attached to SERS-labelled, rod-shaped gold nanoparticles and hybridised with the target miR-21, which was previously immobilised onto the gold slide. sers 69-73 microRNA 21 Homo sapiens 40-46 24460183-5 2014 With this method, highly reproducible and high-quality SERS signals of five typical proteins (lysozyme, avidin, bovine serum albumin, cytochrome c, and hemoglobin) have been obtained, and the SERS features of the proteins without chromophore were almost identical to the respective normal Raman spectra. sers 55-59 albumin Homo sapiens 119-132 24376182-5 2014 Herein we overcome these difficulties by utilizing Surface-Enhanced Raman Spectroscopy (SERS) with a model amyloid peptide, insulin. sers 88-92 insulin Homo sapiens 124-131 24481674-3 2014 For this purpose, we applied surface-enhanced Raman spectroscopy (SERS) to find out the mechanism of SPR-assisted activation of oxygen, by using p-aminothiophenol (PATP), which undergoes a SPR-assisted selective oxidation, as a probe molecule. sers 66-70 sepiapterin reductase Homo sapiens 101-104 24481674-3 2014 For this purpose, we applied surface-enhanced Raman spectroscopy (SERS) to find out the mechanism of SPR-assisted activation of oxygen, by using p-aminothiophenol (PATP), which undergoes a SPR-assisted selective oxidation, as a probe molecule. sers 66-70 sepiapterin reductase Homo sapiens 189-192 32261280-0 2014 Self-focusing Au@SiO2 nanorods with rhodamine 6G as highly sensitive SERS substrate for carcinoembryonic antigen detection. sers 69-73 CEA cell adhesion molecule 3 Homo sapiens 88-112 32261280-2 2014 The SERS enhancement factor was evaluated for anisotropic Au@SiO2 nanorods with silica shells of various thicknesses, upon which Rhodamine 6G (R6G) dye was applied as a reporter molecule for the quantitative determination of CEA. sers 4-8 CEA cell adhesion molecule 3 Homo sapiens 225-228 32261280-4 2014 The self-focusing character originates from the antibody-antigen interaction, which facilitates the SERS probes assembly and significantly increases the detection sensitivity of the CEA. sers 100-104 CEA cell adhesion molecule 3 Homo sapiens 182-185 32261280-5 2014 Our results show that the SERS technique is able to detect CEA within a wide concentration range. sers 26-30 CEA cell adhesion molecule 3 Homo sapiens 59-62 23557978-0 2013 Highly sensitive detection of thrombin using SERS-based magnetic aptasensors. sers 45-49 coagulation factor II, thrombin Homo sapiens 30-38 24456597-1 2014 The gold nanostar@silica core-shell nanoparticles conjugated with glucose oxidase (GOx) enzyme molecules have been developed as the surface-enhanced Raman scattering (SERS) biosensor for label-free detection of glucose. sers 167-171 hydroxyacid oxidase 1 Homo sapiens 66-81 24456597-1 2014 The gold nanostar@silica core-shell nanoparticles conjugated with glucose oxidase (GOx) enzyme molecules have been developed as the surface-enhanced Raman scattering (SERS) biosensor for label-free detection of glucose. sers 167-171 hydroxyacid oxidase 1 Homo sapiens 83-86 24456597-4 2014 The SERS signal of nanostar@silica~GOx nanoparticle-based sensing assay shows the dynamic response to the glucose concentration range from 25 muM to 25 mM in the aqueous solution with the limit of detection of 16 muM. sers 4-8 hydroxyacid oxidase 1 Homo sapiens 35-38 24273118-3 2013 We demonstrate that the transferred Au NWs on the Au substrate can act as sensitive, reproducible, and long-term-stable surface-enhanced Raman scattering (SERS) sensors by detecting human alpha-thrombin as well as Pb(2+) and Hg(2+) ions. sers 155-159 coagulation factor II, thrombin Homo sapiens 194-202 24273118-4 2013 These three biochemically and/or environmentally important analytes were successfully detected with high sensitivity and selectivity by Au NW-SERS sensors bound by a thrombin-binding aptamer. sers 142-146 coagulation factor II, thrombin Homo sapiens 166-174 24370945-2 2014 In this work, the mechanism of the interaction between S(4)TdR and human serum albumin (HSA) was exploited by fluorescence, UV, CD circular, and SERS spectroscopic. sers 145-149 albumin Homo sapiens 73-86 24047198-0 2013 Selective and sensitive detection of intracellular O2( -) using Au NPs/cytochrome c as SERS nanosensors. sers 87-91 cytochrome c, somatic Homo sapiens 71-83 24047198-1 2013 A novel surface-enhanced Raman scattering (SERS) nanosensor was developed by modifying oxidized cytochrome c (Cyt c) on gold nanoparticles (Au NPs) for the sensitive and selective determination of intracellular superoxide anion radical (O2( -)). sers 43-47 cytochrome c, somatic Homo sapiens 96-108 24047198-1 2013 A novel surface-enhanced Raman scattering (SERS) nanosensor was developed by modifying oxidized cytochrome c (Cyt c) on gold nanoparticles (Au NPs) for the sensitive and selective determination of intracellular superoxide anion radical (O2( -)). sers 43-47 cytochrome c, somatic Homo sapiens 110-115 24047198-2 2013 On the basis of the differences in the SERS spectra between the oxidized and reduced form of Cyt c, this nanosensor could be employed to investigate O2( -) concentration by measuring the SERS spectra of the reduced Cyt c. sers 39-43 cytochrome c, somatic Homo sapiens 93-98 24047198-2 2013 On the basis of the differences in the SERS spectra between the oxidized and reduced form of Cyt c, this nanosensor could be employed to investigate O2( -) concentration by measuring the SERS spectra of the reduced Cyt c. sers 39-43 cytochrome c, somatic Homo sapiens 215-220 24047198-2 2013 On the basis of the differences in the SERS spectra between the oxidized and reduced form of Cyt c, this nanosensor could be employed to investigate O2( -) concentration by measuring the SERS spectra of the reduced Cyt c. sers 187-191 cytochrome c, somatic Homo sapiens 93-98 24047198-2 2013 On the basis of the differences in the SERS spectra between the oxidized and reduced form of Cyt c, this nanosensor could be employed to investigate O2( -) concentration by measuring the SERS spectra of the reduced Cyt c. sers 187-191 cytochrome c, somatic Homo sapiens 215-220 23557978-1 2013 This paper reports a method of highly sensitive detection of thrombin using a surface-enhanced Raman scattering (SERS)-based magnetic aptasensor. sers 113-117 coagulation factor II, thrombin Homo sapiens 61-69 23557978-6 2013 The limit of detection (LOD) of thrombin, determined by the SERS-based aptasensor, was estimated to be 0.27pM. sers 60-64 coagulation factor II, thrombin Homo sapiens 32-40 23885927-0 2013 A SERS-based sandwich assay for ultrasensitive and selective detection of Alzheimer"s tau protein. sers 2-6 microtubule associated protein tau Homo sapiens 86-89 23885927-4 2013 The correlation between the tau concentration and SERS signal was found to be linear within the range of 25 fM to 500 nM. sers 50-54 microtubule associated protein tau Homo sapiens 28-31 23202809-0 2013 Effect of potential on temperature-dependent SERS spectra of neuromedin B on Cu electrode. sers 45-49 neuromedin B Homo sapiens 61-73 23930980-1 2013 The heme protein cytochrome c adsorbed to a two-layer gold surface modified with a self-assembled monolayer of 2-mercaptoethanol was analyzed using a two-dimensional (2D) heterospectral correlation analysis that combined surface-enhanced infrared absorption spectroscopy (SEIRAS) and surface-enhanced Raman spectroscopy (SERS). sers 321-325 cytochrome c, somatic Homo sapiens 17-29 23815097-0 2013 Highly sensitive SERS quantification of the oncogenic protein c-Jun in cellular extracts. sers 17-21 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 62-67 23815097-1 2013 A surface-enhanced Raman scattering (SERS)-based sensor was developed for the detection of the oncoprotein c-Jun at nanomolar levels. sers 37-41 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 107-112 23815097-4 2013 The TP functionality anchors the c-Fos protein onto the metal substrate and works as an effective SERS probe to sense the structural rearrangements associated with the c-Fos/c-Jun heterodimerization. sers 98-102 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 33-38 23815097-4 2013 The TP functionality anchors the c-Fos protein onto the metal substrate and works as an effective SERS probe to sense the structural rearrangements associated with the c-Fos/c-Jun heterodimerization. sers 98-102 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 168-173 23815097-4 2013 The TP functionality anchors the c-Fos protein onto the metal substrate and works as an effective SERS probe to sense the structural rearrangements associated with the c-Fos/c-Jun heterodimerization. sers 98-102 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 174-179 23650627-0 2013 Simultaneous evaluation of p53 and p21 expression level for early cancer diagnosis using SERS technique. sers 89-93 tumor protein p53 Homo sapiens 27-30 23650627-0 2013 Simultaneous evaluation of p53 and p21 expression level for early cancer diagnosis using SERS technique. sers 89-93 cyclin dependent kinase inhibitor 1A Homo sapiens 35-38 23650627-1 2013 Simultaneous detection of tumor suppressor p53 and cyclin-dependent kinase inhibitor p21 has been achieved for the first time with a high sensitivity using surface enhanced Raman scattering (SERS) technique. sers 191-195 tumor protein p53 Homo sapiens 43-46 23650627-1 2013 Simultaneous detection of tumor suppressor p53 and cyclin-dependent kinase inhibitor p21 has been achieved for the first time with a high sensitivity using surface enhanced Raman scattering (SERS) technique. sers 191-195 cyclin dependent kinase inhibitor 1A Homo sapiens 85-88 23650627-3 2013 Qualitative and quantitative analysis of p53 and p21 were achieved by characterizing SERS signals of two different Raman reporters (4MBA and DTNB), which were labeled on the corresponding optical probes. sers 85-89 tumor protein p53 Homo sapiens 41-44 23650627-3 2013 Qualitative and quantitative analysis of p53 and p21 were achieved by characterizing SERS signals of two different Raman reporters (4MBA and DTNB), which were labeled on the corresponding optical probes. sers 85-89 cyclin dependent kinase inhibitor 1A Homo sapiens 49-52 23650627-7 2013 Since the combined evaluation of p53 and p21 expression level acts as an indicator for early cancer prediction, our demonstrated immunoassay will potentially promote the application of SERS technique to practical clinical diagnoses. sers 185-189 tumor protein p53 Homo sapiens 33-36 23650627-7 2013 Since the combined evaluation of p53 and p21 expression level acts as an indicator for early cancer prediction, our demonstrated immunoassay will potentially promote the application of SERS technique to practical clinical diagnoses. sers 185-189 cyclin dependent kinase inhibitor 1A Homo sapiens 41-44 23461631-9 2013 Furthermore, the observation of NIR-induced switching with a continuous wave source holds important consequences in the study of photochromic switches on surfaces using SERS and emphasizes the importance of the use of multiple complementary techniques in characterizing photoresponsive SAMs. sers 169-173 NOC2 like nucleolar associated transcriptional repressor Homo sapiens 32-35 22936106-2 2013 Juhasz, Yap, Dicke, Taylor, and Gullick (Quarterly Journal of Experimental Psychology 64:1683-1691, 2011) demonstrated that SERs predict a significant amount of variance in lexical-decision response times in two megastudies of lexical processing when a large number of established psycholinguistic variables are controlled for. sers 124-128 Yes1 associated transcriptional regulator Homo sapiens 8-11 22936106-5 2013 New analyses with the combined set of words confirmed that SERs predict a reliable amount of variance in the lexical-decision response times and naming times from the English Lexicon Project (Balota, Yap, Cortese, Hutchison, Kessler, Loftus, & Treiman, Behavior Research Methods 39:445-459, 2007) when a large number of surface, lexical, and semantic variables are statistically controlled for. sers 59-63 Yes1 associated transcriptional regulator Homo sapiens 200-203 28348328-5 2013 A highly energetic material, TNT, was used as the target compound in the SERS experiments. sers 73-77 chromosome 16 open reading frame 82 Homo sapiens 29-32 23934392-1 2013 Microextraction by packed sorbents (MEPS) combined with Surface-enhanced Raman spectroscopy (SERS) was investigated, and applied to the determination of musk ketone (MK) in river water samples. sers 93-97 muscle associated receptor tyrosine kinase Homo sapiens 153-157 23934392-2 2013 The full MEPS-SERS method includes analyte enrichment by MEPS preconcentration with C18 sorbent followed by SERS detection supported by silver nanoparticles. sers 14-18 Bardet-Biedl syndrome 9 Homo sapiens 84-87 24369644-2 2013 In order to achieve a better understanding of the structural attribute of the Vitamin B12 molecule when it interacted with metal, in the present paper, the vitamin B12 molecules adsorbed on variation of copper electrode potential from 0 to -1.0 V was studied by surface-enhanced Raman spectroscopy (SERS). sers 299-303 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 86-89 24369644-4 2013 Assignments of Raman peaks observed by normal Raman spectrum (NRS) and SERS spectra of vitamin B12 molecule were given based on previous literatures. sers 71-75 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 95-98 24369644-5 2013 It was found that the potential-dependent relative intensity changed in SERS spectra which depended on the vitamin B12 molecular orientation with respect to the copper surface according to the surface selection rule (SSR). sers 72-76 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 115-118 23380645-0 2013 A "turn-off" SERS-based detection platform for ultrasensitive detection of thrombin based on enzymatic assays. sers 13-17 coagulation factor II, thrombin Homo sapiens 75-83 23380645-1 2013 Herein we describe a novel "turn-off" biosensing strategy for thrombin detection based on Surface Enhanced Raman scattering (SERS) and the mediation of spacing between 4-mercaptobenzoic acid (4-MBA) labeled gold nanoparticles (AuNPs). sers 125-129 coagulation factor II, thrombin Homo sapiens 62-70 23380645-2 2013 The multiple arginine peptides that initiated gold nano-aggregates incorporating Raman reporter molecules due to the formation of "Hot Spots", are induced to disband by the addition of thrombin in which the peptides are catalytically cleaved into fragments and thus SERS signals of 4-MBA are sharply declined because of the weakened ability of fragments to induce aggregation. sers 266-270 coagulation factor II, thrombin Homo sapiens 185-193 23380645-3 2013 Through this strategy, a novel "turn-off" SERS biosensor for thrombin based on enzymatic amplification is established with sensitivity, selectivity and simplicity as AuNPs and peptides are easily accessible. sers 42-46 coagulation factor II, thrombin Homo sapiens 61-69 23694695-0 2013 Raman and surface-enhanced Raman scattering (SERS) studies of the thrombin-binding aptamer. sers 45-49 coagulation factor II, thrombin Homo sapiens 66-74 23343449-5 2013 Several analytes as methylene blue, p-aminothiophenol, amoxicillin, and Cu(PAR)2 were used to prove SERS enhancement of the obtained silver colloid. sers 100-104 F2R like trypsin receptor 1 Homo sapiens 75-80 23202809-1 2013 Adsorption of decapeptide neuromedin B (NMB) on copper electrode has been investigated by in situ surface-enhanced Raman scattering (SERS) spectroelectrochemistry in the temperature interval from 12 to 72 C at -0.600 and -1.000 V potentials. sers 133-137 neuromedin B Homo sapiens 26-38 23202809-1 2013 Adsorption of decapeptide neuromedin B (NMB) on copper electrode has been investigated by in situ surface-enhanced Raman scattering (SERS) spectroelectrochemistry in the temperature interval from 12 to 72 C at -0.600 and -1.000 V potentials. sers 133-137 neuromedin B Homo sapiens 40-43 23033199-1 2012 A novel surface-enhanced Raman scattering (SERS) assay is demonstrated by developing a cross strand-displacement amplification (CSDA) method to enhance the SERS signals. sers 43-47 Y-box binding protein 3 Homo sapiens 128-132 24110208-6 2013 With gold substrate, our work here intends to explore if SERS is suitable to detect NS1 from saliva, with saliva becoming the most favored alternative to blood as diagnostic fluid due to its advantages in sample collection. sers 57-61 influenza virus NS1A binding protein Homo sapiens 84-87 23381867-5 2013 By employing SERS, we have not only demonstrated the autoacetylation induced structural changes of p300 enzyme but also could use this technique to characterize and design potent, specific inhibitors as well as activators of the p300. sers 13-17 E1A binding protein p300 Homo sapiens 99-103 23381867-5 2013 By employing SERS, we have not only demonstrated the autoacetylation induced structural changes of p300 enzyme but also could use this technique to characterize and design potent, specific inhibitors as well as activators of the p300. sers 13-17 E1A binding protein p300 Homo sapiens 229-233 22542823-0 2013 Evaluation of SERS labeling of CD20 on CLL cells using optical microscopy and fluorescence flow cytometry. sers 14-18 keratin 20 Homo sapiens 31-35 22542823-3 2013 We report and evaluate the use of surface-enhanced Raman scattering (SERS) gold NPs (AuNPs) conjugated to therapeutic rituximab antibodies for selective targeting of CD20 molecules. sers 69-73 keratin 20 Homo sapiens 166-170 22542823-5 2013 The effective targeting of CD20 on chronic lymphocytic leukemia cells by rituximab-conjugated SERS AuNPs was evaluated by dark-field imaging, Raman spectroscopy, and flow cytometry with both competitive binding and fluorescence detection procedures. sers 94-98 keratin 20 Homo sapiens 27-31 23033199-1 2012 A novel surface-enhanced Raman scattering (SERS) assay is demonstrated by developing a cross strand-displacement amplification (CSDA) method to enhance the SERS signals. sers 156-160 Y-box binding protein 3 Homo sapiens 128-132 22710368-3 2012 We have demonstrated the conformational changes in the tertiary structures of the Lyz molecules on EGCG binding using surface-enhanced Raman scattering (SERS) and circular dichroism (CD) spectroscopic measurements. sers 153-157 lysozyme Homo sapiens 82-85 22899096-0 2012 Enhanced sensitivity of a direct SERS technique for Hg2+ detection based on the investigation of the interaction between silver nanoparticles and mercury ions. sers 33-37 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 52-55 22816780-5 2012 SERS allowed noninvasive measurement of ICAM-1 expression in vivo with twice the sensitivity of two-photon fluorescence. sers 0-4 intercellular adhesion molecule 1 Homo sapiens 40-46 23043369-3 2012 In this work, we demonstrated the potential of surface-enhanced Raman scattering (SERS) conducted using a polyethylenimine (PEI)-capped Ag nanoparticle film for the quantification of an electrostatic adsorption process of charged drug molecules, by using charged dye molecules such as sulforhodamine B (SRB) and rhodamine-123 (R123) as model drugs. sers 82-86 chaperonin containing TCP1 subunit 4 Homo sapiens 285-301 23043369-3 2012 In this work, we demonstrated the potential of surface-enhanced Raman scattering (SERS) conducted using a polyethylenimine (PEI)-capped Ag nanoparticle film for the quantification of an electrostatic adsorption process of charged drug molecules, by using charged dye molecules such as sulforhodamine B (SRB) and rhodamine-123 (R123) as model drugs. sers 82-86 chaperonin containing TCP1 subunit 4 Homo sapiens 303-306 23043369-5 2012 We were subsequently able to detect a prototype anionic dye molecule, SRB, by SERS at a subnanomolar concentration. sers 78-82 chaperonin containing TCP1 subunit 4 Homo sapiens 70-73 22881392-4 2012 To overcome this interference, we encapsulated pH SERS sensors in a 30 nm thick silica layer with small pores which prevented bovine serum albumin (BSA) molecules from interacting with the pH-indicating 4-mercaptobenzoic acid (4-MBA) on the silver surfaces but preserved the pH-sensitivity. sers 50-54 albumin Mus musculus 133-146 22710368-4 2012 From the analysis of the amide I band of Lyz in SERS and CD spectra, the site of interaction of EGCG with protein molecules in Lyz-conjugated Ag particles has been identified. sers 49-53 lysozyme Homo sapiens 41-44 22556265-4 2012 Surface-enhanced Raman scattering (SERS)-active nanoparticles, functionalized with a p53 peptide mimic (peptide 12.1), display biologically specific aggregation following addition of MDM2. sers 35-39 transformation related protein 53, pseudogene Mus musculus 85-88 22556265-4 2012 Surface-enhanced Raman scattering (SERS)-active nanoparticles, functionalized with a p53 peptide mimic (peptide 12.1), display biologically specific aggregation following addition of MDM2. sers 35-39 transformed mouse 3T3 cell double minute 2 Mus musculus 183-187 22278595-5 2012 Further investigation indicates that GS/mPHP/Au hybrids are promising surface enhanced Raman scattering (SERS) substrates. sers 105-109 phosphohistidine phosphatase 1 Mus musculus 40-44 22265083-5 2012 Highly sensitive detection of protein was achieved using anti-EGFR antibody conjugated SERS nanotag. sers 87-91 epidermal growth factor receptor Homo sapiens 62-66 22278595-7 2012 The GS/mPHP/Au hybrid containing continuous Au films exhibits the strongest SERS activity. sers 76-80 phosphohistidine phosphatase 1 Mus musculus 7-11 22129682-6 2012 This single base extension reaction-based SERS can determine methylated DNA with a detection limit of 3 pM, and can even distinguish as low as 1% methylation level in tumor suppressor gene CDKN2/p16/MTS1 (p16) from the mixtures. sers 42-46 cyclin dependent kinase inhibitor 2A Homo sapiens 189-194 22127578-3 2012 Here, we present a rapid, highly sensitive and label-free analytical technique for determining bovine serum albumin (BSA) on a poly(dimethylsiloxane) (PDMS) microfluidic chip using SERS. sers 181-185 albumin Homo sapiens 102-115 22107062-4 2012 We experimentally demonstrate the feasibility of this particular approach and report, for the first time, the acquisition of whole-protein SERS spectra of a layer of test protein, Cytochrome-c, using a custom-made Otto-Raman spectroscopy system equipped with nano-fluidics. sers 139-143 cytochrome c, somatic Homo sapiens 180-192 22129682-6 2012 This single base extension reaction-based SERS can determine methylated DNA with a detection limit of 3 pM, and can even distinguish as low as 1% methylation level in tumor suppressor gene CDKN2/p16/MTS1 (p16) from the mixtures. sers 42-46 cyclin dependent kinase inhibitor 2A Homo sapiens 195-198 22129682-6 2012 This single base extension reaction-based SERS can determine methylated DNA with a detection limit of 3 pM, and can even distinguish as low as 1% methylation level in tumor suppressor gene CDKN2/p16/MTS1 (p16) from the mixtures. sers 42-46 cyclin dependent kinase inhibitor 2A Homo sapiens 199-203 22129682-6 2012 This single base extension reaction-based SERS can determine methylated DNA with a detection limit of 3 pM, and can even distinguish as low as 1% methylation level in tumor suppressor gene CDKN2/p16/MTS1 (p16) from the mixtures. sers 42-46 cyclin dependent kinase inhibitor 2A Homo sapiens 205-208 22080302-8 2012 In this work, the fabrication and characterization of the SERS-fluorescence DMNPs and application to biological imaging were investigated using markers CD24 and CD44, which are co-expressed in MDA-MB-231 breast cancer cells, as a model system. sers 58-62 CD24 molecule Homo sapiens 152-156 22080302-8 2012 In this work, the fabrication and characterization of the SERS-fluorescence DMNPs and application to biological imaging were investigated using markers CD24 and CD44, which are co-expressed in MDA-MB-231 breast cancer cells, as a model system. sers 58-62 CD44 molecule (Indian blood group) Homo sapiens 161-165 22080302-9 2012 SERS imaging with DMNPs was found to be a powerful tool to determine the co-localization of CD24 and CD44 in the cell. sers 0-4 CD24 molecule Homo sapiens 92-96 22080302-9 2012 SERS imaging with DMNPs was found to be a powerful tool to determine the co-localization of CD24 and CD44 in the cell. sers 0-4 CD44 molecule (Indian blood group) Homo sapiens 101-105 22124755-2 2012 For the aim of the detection, a novel surface-enhanced Raman scattering (SERS) probe for distinguishing breast cancers at different HER2 statuses is reported in this paper. sers 73-77 erb-b2 receptor tyrosine kinase 2 Homo sapiens 132-136 22124755-6 2012 The experimental results reveal that SKBR3 cells exhibit much stronger SERS signals than MCF7 cells, indicating that the probe could be utilized to distinguish breast cancer cells at different HER2 statuses. sers 71-75 erb-b2 receptor tyrosine kinase 2 Homo sapiens 193-197 22263910-1 2012 Tip-enhanced Raman spectroscopy (TERS) is a very powerful variant of surface-enhanced Raman spectroscopy (SERS). sers 106-110 TOR signaling pathway regulator Homo sapiens 0-3 21968023-0 2011 Modulation of abnormal synaptic transmission in hippocampal CA3 neurons of spontaneously epileptic rats (SERs) by levetiracetam. sers 105-109 carbonic anhydrase 3 Rattus norvegicus 60-63 22275824-2 2012 Here we report a new methodology based on highly specific and sensitive surface-enhanced Raman scattering (SERS) technology to detect LMP1 in nasopharyngeal tissue sections directly with no need of tedious procedures as with conventional immunohistochemistry methods. sers 107-111 PDZ and LIM domain 7 Homo sapiens 134-138 22275824-5 2012 RESULTS: Data from SERS spectra and images show that this new SERS-based immunoassay detected LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections with high sensitivity and specificity. sers 19-23 PDZ and LIM domain 7 Homo sapiens 94-98 22275824-5 2012 RESULTS: Data from SERS spectra and images show that this new SERS-based immunoassay detected LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections with high sensitivity and specificity. sers 62-66 PDZ and LIM domain 7 Homo sapiens 94-98 22275824-6 2012 The results from the new LMP1-SERS probe method are superior to those of conventional immunohistochemistry staining for LMP1, and in excellent agreement with those of in situ hybridization for EBV-encoded small RNA (EBER). sers 30-34 PDZ and LIM domain 7 Homo sapiens 25-29 21997793-4 2011 In this study, the surface-enhanced Raman scattering (SERS) technique is used to characterize the conformational changes of a protein (lysozyme) adsorbed on tailored flat gold substrates with different chemistries. sers 54-58 lysozyme Homo sapiens 135-143 21366283-17 2011 Surface-enhanced Raman scattering (SERS) activity of the system could be tuned by controlling the concentration of EDTA and the metal ion, Pb(II). sers 35-39 submaxillary gland androgen regulated protein 3B Homo sapiens 139-145 21889639-1 2011 A new sensitive surface-enhanced Raman scattering (SERS) assay for detection of cholinesterase inhibitors such as organophosphorous pesticides using silver colloidal nanoparticles was developed and optimized. sers 51-55 butyrylcholinesterase Homo sapiens 80-94 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. sers 163-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. sers 163-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21824000-4 2011 The SERS substrate is successfully utilized in the detection of a trace amount of three different proteins, bovin serum albumin, immunoglobulin G, and cardiac troponin T, also adsorbed on the substrate surface. sers 4-8 albumin Homo sapiens 114-127 21604751-5 2011 Electromagnetic simulations of the polygonal structures were performed to visualize the field enhancements of the hot spots so as to guide the rational design of optimal SERS structures. sers 170-174 alcohol dehydrogenase iron containing 1 Homo sapiens 114-117 21942274-0 2011 Protein-based SERS technology monitoring the chemical reactivity on an alpha-synuclein-mediated two-dimensional array of gold nanoparticles. sers 14-18 synuclein alpha Homo sapiens 71-86 21942274-2 2011 By employing the Parkinson"s disease-related protein of alpha-synuclein, we introduce SERS-active gold nanoparticles (AuNPs) individually isolated with an ultrathin alpha-synuclein shell and their 2-D array into a tightly packed monolayer on a glass support, which permits a quantitative SERS measurement of phthalocyanine tetrasulfonate (PcTS), a chemical ligand of the pathological protein. sers 86-90 synuclein alpha Homo sapiens 56-71 21942274-2 2011 By employing the Parkinson"s disease-related protein of alpha-synuclein, we introduce SERS-active gold nanoparticles (AuNPs) individually isolated with an ultrathin alpha-synuclein shell and their 2-D array into a tightly packed monolayer on a glass support, which permits a quantitative SERS measurement of phthalocyanine tetrasulfonate (PcTS), a chemical ligand of the pathological protein. sers 86-90 synuclein alpha Homo sapiens 165-180 21942274-2 2011 By employing the Parkinson"s disease-related protein of alpha-synuclein, we introduce SERS-active gold nanoparticles (AuNPs) individually isolated with an ultrathin alpha-synuclein shell and their 2-D array into a tightly packed monolayer on a glass support, which permits a quantitative SERS measurement of phthalocyanine tetrasulfonate (PcTS), a chemical ligand of the pathological protein. sers 288-292 synuclein alpha Homo sapiens 56-71 21735511-1 2011 We present a detailed analysis of the surface-enhanced Raman scattering (SERS) of adenine and 2"-deoxyadenosine 5"-monophosphate (dAMP) adsorbed on an Ag(20) cluster by using density functional theory. sers 73-77 Amphiphysin Drosophila melanogaster 130-134 21735511-6 2011 Furthermore, the spectrum of dAMP bound to the Ag(20) cluster via N7 approaches the experimental SERS spectra on silver colloids. sers 97-101 Amphiphysin Drosophila melanogaster 29-33 21614397-1 2011 We describe a surface-enhanced Raman scattering (SERS)-based sensor for the detection of human serum albumin (HSA) using gold "pearl necklace" nanomaterials (Au PNNs) as the substrate and AB 580 as the reporter. sers 49-53 albumin Homo sapiens 95-108 21359568-2 2011 Using LOC-SERS, the enzyme activity of thiopurine S-methyltransferase (TPMT) is analysed and identified in lysed red blood cells. sers 10-14 thiopurine S-methyltransferase Homo sapiens 39-69 21359568-2 2011 Using LOC-SERS, the enzyme activity of thiopurine S-methyltransferase (TPMT) is analysed and identified in lysed red blood cells. sers 10-14 thiopurine S-methyltransferase Homo sapiens 71-75 20872871-3 2011 SERS samples of P37 were prepared by coating the solid peptide with metal colloids on a quartz slide. sers 0-4 nucleoporin 37 Homo sapiens 16-19 21391573-7 2011 In addressing this obstacle, the work herein examines the potential to create a simple diagnostic test for MUC4 through the development of a surface-enhanced Raman scattering (SERS)-based immunoassay, which was then used to demonstrate the first ever detection of MUC4 in cancer patient serum samples. sers 176-180 mucin 4, cell surface associated Homo sapiens 107-111 21391573-7 2011 In addressing this obstacle, the work herein examines the potential to create a simple diagnostic test for MUC4 through the development of a surface-enhanced Raman scattering (SERS)-based immunoassay, which was then used to demonstrate the first ever detection of MUC4 in cancer patient serum samples. sers 176-180 mucin 4, cell surface associated Homo sapiens 264-268 21391573-8 2011 Importantly, these measurements showed that sera from patients with PC produced a significantly higher SERS response for MUC4 compared to sera from healthy individuals and from patients with benign diseases. sers 103-107 mucin 4, cell surface associated Homo sapiens 121-125 21391573-9 2011 These results indicate that a SERS-based immunoassay can monitor MUC4 levels in patient sera, representing a much needed first step toward assessing the potential of this protein to serve as a serum marker for the early stage diagnosis of PC. sers 30-34 mucin 4, cell surface associated Homo sapiens 65-69 21391573-10 2011 This paper details these and other findings (i.e., the detection of the mucin protein CA19-9), which demonstrate that our SERS assay outperforms conventional assays (i.e., RIA and ELISA) with respect to limits of detection, readout time, and required sample volume. sers 122-126 LOC100508689 Homo sapiens 72-77 21322579-4 2011 The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cytochrome c. sers 22-26 kininogen 1 Homo sapiens 120-130 21322579-4 2011 The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cytochrome c. sers 22-26 cytochrome c, somatic Homo sapiens 135-147 20919697-5 2010 Because of the binding of abundance repeated sequences of RCA products with gold nanoparticle (Au NP) and Rox-modified detection probes, SERS signal is significantly amplified and the detection limit of 10.0 pM might be achieved. sers 137-141 MAX network transcriptional repressor Homo sapiens 106-109 21038855-3 2010 The vortex-aligned insulin fibrils are capable of templating nanopatterns in sputtered Au layers without overlapping the SERS spectra of 4-MBA with vibrational bands stemming from the protein. sers 121-125 insulin Homo sapiens 19-26 21030778-4 2010 This SERS study enabled us to estimate high enhancement factors (10(5) for BSA and 10(7) for RNase-A) of important bands in the protein Raman spectrum measured for 1 mM concentration. sers 5-9 ribonuclease A family member 1, pancreatic Homo sapiens 93-100 20853285-0 2010 Ultrasensitive SERS detection of TNT by imprinting molecular recognition using a new type of stable substrate. sers 15-19 chromosome 16 open reading frame 82 Homo sapiens 33-36 20853285-1 2010 We report herein a method for the ultra-trace detection of TNT on p-aminothiophenol-functionalized silver nanoparticles coated on silver molybdate nanowires based on surface-enhanced Raman scattering (SERS). sers 201-205 chromosome 16 open reading frame 82 Homo sapiens 59-62 20853285-5 2010 We demonstrate that TNT concentrations as low as 10(-12) M can be accurately detected using the described SERS assay. sers 106-110 chromosome 16 open reading frame 82 Homo sapiens 20-23 20842349-0 2010 SERS nanosensors that report pH of endocytic compartments during FcepsilonRI transit. sers 0-4 Fc epsilon receptor Ia Homo sapiens 65-76 20842349-1 2010 Recently, the development of an IgE receptor (FcepsilonRI)-targeted, pH-sensitive, surface-enhanced Raman spectroscopy (SERS) nanosensor has been demonstrated by Nowak-Lovato and Rector (Appl Spectrosc 63:387-395, 2009). sers 120-124 Fc epsilon receptor Ia Homo sapiens 46-57 20801634-6 2010 In vitro SERS screening was performed in cancer cell lines using B2LA containing nanotag conjugated with selective antibodies recognizing HER2 and EGFR cancer proteins. sers 9-13 erb-b2 receptor tyrosine kinase 2 Mus musculus 138-142 20621465-1 2010 Writing a molecularly imprinted polymer (MIP) by nano-fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces resulted in site-controlled arrays of microdots of approximately 6-12mum in diameter. sers 105-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 63-66 20801634-6 2010 In vitro SERS screening was performed in cancer cell lines using B2LA containing nanotag conjugated with selective antibodies recognizing HER2 and EGFR cancer proteins. sers 9-13 epidermal growth factor receptor Mus musculus 147-151 20801634-7 2010 We found reasonably strong SERS signals from both HER2 and EGFR positive cells whereas no signal was measured from respective negative cells. sers 27-31 erb-b2 receptor tyrosine kinase 2 Mus musculus 50-54 20801634-7 2010 We found reasonably strong SERS signals from both HER2 and EGFR positive cells whereas no signal was measured from respective negative cells. sers 27-31 epidermal growth factor receptor Mus musculus 59-63 20801634-9 2010 Both SERS and cell-imaging study further confirmed the selective binding of antibody conjugated nanotag to cancer cells over-expressing HER2 and EGFR. sers 5-9 erb-b2 receptor tyrosine kinase 2 Mus musculus 136-140 20801634-9 2010 Both SERS and cell-imaging study further confirmed the selective binding of antibody conjugated nanotag to cancer cells over-expressing HER2 and EGFR. sers 5-9 epidermal growth factor receptor Mus musculus 145-149 20527817-5 2010 Here we report LDR-SERS multiplex SNP genotyping of K-Ras oncogene alleles at 10 pM detection levels, optimization of DNA labeling as well as Raman conditions, and the linear correlation of diagnostic peak intensity to SNP target concentration in heterozygous samples. sers 19-23 KRAS proto-oncogene, GTPase Homo sapiens 52-57 20939326-5 2010 After being used in Rhodamine 6G, prostate-specific antigen and PH sensing experiment, the method was proved to be of high performance and practicability for SERS signal processing. sers 158-162 kallikrein related peptidase 3 Homo sapiens 34-59 20602947-3 2010 SERS label, comprising self-assembled monolayers (SAMs) of Raman reporter molecule (5,5-Dithiobis (2-Nitrobenzoic acid), DTNB), was coated on the surface of the nanoparticles. sers 0-4 dystrobrevin beta Homo sapiens 121-125 20602947-5 2010 The calibration curves were obtained by plotting the intensity of the SERS signal of symmetric NO(2) stretching of DTNB at 1326 cm(-1) vs. the protease concentration. sers 70-74 dystrobrevin beta Homo sapiens 115-119 20683135-1 2010 A tumor cell targeting surface-enhanced Raman scattering (SERS) probe has been successfully synthesized by using p-mercaptobenzoic acid (pMBA) as both the SERS reporter and the conjugation agent for attaching transferrin molecules, which shows experimentally the targeting ability for transferrin receptor-overexpressed HeLa cells and exhibits strong SERS signals when being incubated inside cells. sers 58-62 transferrin Homo sapiens 209-220 20683135-1 2010 A tumor cell targeting surface-enhanced Raman scattering (SERS) probe has been successfully synthesized by using p-mercaptobenzoic acid (pMBA) as both the SERS reporter and the conjugation agent for attaching transferrin molecules, which shows experimentally the targeting ability for transferrin receptor-overexpressed HeLa cells and exhibits strong SERS signals when being incubated inside cells. sers 58-62 transferrin Homo sapiens 285-296 20683135-1 2010 A tumor cell targeting surface-enhanced Raman scattering (SERS) probe has been successfully synthesized by using p-mercaptobenzoic acid (pMBA) as both the SERS reporter and the conjugation agent for attaching transferrin molecules, which shows experimentally the targeting ability for transferrin receptor-overexpressed HeLa cells and exhibits strong SERS signals when being incubated inside cells. sers 155-159 transferrin Homo sapiens 209-220 20683135-1 2010 A tumor cell targeting surface-enhanced Raman scattering (SERS) probe has been successfully synthesized by using p-mercaptobenzoic acid (pMBA) as both the SERS reporter and the conjugation agent for attaching transferrin molecules, which shows experimentally the targeting ability for transferrin receptor-overexpressed HeLa cells and exhibits strong SERS signals when being incubated inside cells. sers 155-159 transferrin Homo sapiens 285-296 20683135-1 2010 A tumor cell targeting surface-enhanced Raman scattering (SERS) probe has been successfully synthesized by using p-mercaptobenzoic acid (pMBA) as both the SERS reporter and the conjugation agent for attaching transferrin molecules, which shows experimentally the targeting ability for transferrin receptor-overexpressed HeLa cells and exhibits strong SERS signals when being incubated inside cells. sers 155-159 transferrin Homo sapiens 209-220 20683135-1 2010 A tumor cell targeting surface-enhanced Raman scattering (SERS) probe has been successfully synthesized by using p-mercaptobenzoic acid (pMBA) as both the SERS reporter and the conjugation agent for attaching transferrin molecules, which shows experimentally the targeting ability for transferrin receptor-overexpressed HeLa cells and exhibits strong SERS signals when being incubated inside cells. sers 155-159 transferrin Homo sapiens 285-296 20683135-2 2010 To prove that the uptake of such a SERS probe is through a Tf-receptor-mediated endocytosis process, two control experiments: (1) HeLa cells being incubated with the probe at 4 degrees C and (2) HeLa cells being pre-blocked with free transferrin at 37 degrees C, were employed. sers 35-39 transferrin Homo sapiens 234-245 20683135-3 2010 The difference of SERS intensity between the transferrin-overexpressed HeLa cells and transferrin-pre-blocked HeLa cells indicates that the probe has the potential to selectively target tumor cells. sers 18-22 transferrin Homo sapiens 45-56 20683135-3 2010 The difference of SERS intensity between the transferrin-overexpressed HeLa cells and transferrin-pre-blocked HeLa cells indicates that the probe has the potential to selectively target tumor cells. sers 18-22 transferrin Homo sapiens 86-97 19857952-1 2010 Here we present an optofluidic surface enhanced Raman spectroscopy (SERS) device for on-chip detection of vasopressin using an aptamer based binding assay. sers 68-72 arginine vasopressin Homo sapiens 106-117 20414915-0 2010 SERS of beta-thioglucose adsorbed on nanostructured silver electrodes. sers 0-4 pro-platelet basic protein Homo sapiens 8-24 20414915-2 2010 These nanostructured electrodes in conjunction with a Raman microprobe spectrometer were used to obtain surface-enhanced Raman spectra (SERS) of beta-thioglucose (beta-TG) under potential control. sers 136-140 pro-platelet basic protein Homo sapiens 145-161 20414915-2 2010 These nanostructured electrodes in conjunction with a Raman microprobe spectrometer were used to obtain surface-enhanced Raman spectra (SERS) of beta-thioglucose (beta-TG) under potential control. sers 136-140 pro-platelet basic protein Homo sapiens 163-170 20063154-5 2010 As a proof of concept, this SERS-based protein-DNA interaction assay is validated by studying the binding of a zinc finger transcription factor WT1 with DNA sequences derived from the promoter of the human vascular endothelial growth factor. sers 28-32 WT1 transcription factor Homo sapiens 144-147 20063154-5 2010 As a proof of concept, this SERS-based protein-DNA interaction assay is validated by studying the binding of a zinc finger transcription factor WT1 with DNA sequences derived from the promoter of the human vascular endothelial growth factor. sers 28-32 vascular endothelial growth factor A Homo sapiens 206-240 20799837-1 2010 In this study, we exploit the sensitivity offered by surface-enhanced Raman scattering (SERS) for the direct detection of thrombin using the thrombin-binding aptamer (TBA) as molecular receptor. sers 88-92 coagulation factor II, thrombin Homo sapiens 122-130 20799837-1 2010 In this study, we exploit the sensitivity offered by surface-enhanced Raman scattering (SERS) for the direct detection of thrombin using the thrombin-binding aptamer (TBA) as molecular receptor. sers 88-92 coagulation factor II, thrombin Homo sapiens 141-149 19486693-3 2009 A strategy integrating S1 nuclease digestion with SERS detection was developed to quantify the expression levels of splice junction Delta(9,10), a segment of the breast cancer susceptibility gene 1 (BRCA1) from MCF-7 and MDA-MB-231 cells. sers 50-54 BRCA1 DNA repair associated Homo sapiens 199-204 19725622-2 2009 A comparison with the commonly used plane wave (PW) approximation, /E(loc)(omega)/2 /E(loc)(omega(")/2, which for zero Stokes shift is /E(loc)(omega)/4, is made so as to determine the error associated with using the PW enhancement factor instead of DR in modeling SERS intensities. sers 264-268 elongin C Homo sapiens 68-83 19690725-9 2009 Finally, dual SAM SERS labels are used in immuno-SERS microscopy for selective imaging of prostate-specific antigen in the epithelium of biopsies from patients with prostate cancer. sers 18-22 kallikrein related peptidase 3 Homo sapiens 90-115 19690725-9 2009 Finally, dual SAM SERS labels are used in immuno-SERS microscopy for selective imaging of prostate-specific antigen in the epithelium of biopsies from patients with prostate cancer. sers 49-53 kallikrein related peptidase 3 Homo sapiens 90-115 19950646-5 2009 After a series of calibration, the results revealed that the SERS spectral features of SCN from the mixture system were similar to those from the pure Ag nanoparticles, indicating the coupling effect between the Ag and Au nanoparticles, which results in the property of Au inclining to Ag. sers 61-65 sorcin Homo sapiens 87-90 18098178-3 2008 It is also used surface enhanced Raman scattering (SERS) to study the differences and changes in the vibrational spectra of BN and its analogs, which were attached to an electrochemically roughened silver surface as these peptides interacted with target proteins. sers 51-55 gastrin releasing peptide Homo sapiens 124-126 19488135-5 2009 A sensitivity of 1 muM was achieved at low excitation irradiance, and a semilinear concentration dependence was found for concentrations below 100 muM, demonstrating the potential of these ChG-based SERS substrates for high-sensitivity quantitative analysis. sers 199-203 latexin Homo sapiens 19-22 19488135-5 2009 A sensitivity of 1 muM was achieved at low excitation irradiance, and a semilinear concentration dependence was found for concentrations below 100 muM, demonstrating the potential of these ChG-based SERS substrates for high-sensitivity quantitative analysis. sers 199-203 latexin Homo sapiens 147-150 19301845-6 2009 For the validation of our SERS immunoassay, a well-known lung cancer marker, carcinoembryonic antigen (CEA), was used as a target marker. sers 26-30 CEA cell adhesion molecule 3 Homo sapiens 77-101 19301845-6 2009 For the validation of our SERS immunoassay, a well-known lung cancer marker, carcinoembryonic antigen (CEA), was used as a target marker. sers 26-30 CEA cell adhesion molecule 3 Homo sapiens 103-106 19082172-0 2009 Isotachophoretic free-flow electrophoretic focusing and SERS detection of myoglobin inside a miniaturized device. sers 56-60 myoglobin Homo sapiens 74-83 18583578-1 2008 On nanotextured noble-metal surfaces, surface-enhanced Raman scattering (SERS) is observed, where Raman scattering is enhanced by a factor, G, that is frequently about one million, but underlying the factor G is a broad distribution of local enhancement factors, eta. sers 73-77 endothelin receptor type A Homo sapiens 23-26 18583578-5 2008 The hottest sites (eta >10(9)) account for just 63 in 1,000,000 of the total but contribute 24% to the overall SERS intensity. sers 114-118 endothelin receptor type A Homo sapiens 19-22 19117446-1 2009 We have developed an electrostatic interaction based biosensor for thrombin detection using surface-enhanced Raman spectroscopy (SERS). sers 129-133 coagulation factor II, thrombin Homo sapiens 67-75 18759412-1 2008 Raman (RS) and surface-enhanced Raman scattering spectra (SERS) were measured for various length carboxyl terminal fragments (X-14 of amino acid sequence) of bombesin ( BN): BN13-14, BN12-14, BN11-14, BN10-14, BN9-14, and BN8-14 in silver colloidal solutions. sers 58-62 gastrin releasing peptide Homo sapiens 158-166 17417897-8 2007 Surface-enhanced Raman spectroscopy (SERS) of p300 and the HAT activator complexes evidently suggest that the activation of HAT activity is achieved by the alteration of p300 structure. sers 37-41 E1A binding protein p300 Homo sapiens 46-50 17629308-1 2007 In this work, surface-enhanced Raman scattering (SERS) was applied to probe the orientation of cytochrome c (Cyt-c) on gold nanohole arrays functionalized with self-assembled monolayers (SAMs) of alkane thiols with positively (-NH2) and negatively (-COOH) charged terminal groups. sers 49-53 cytochrome c, somatic Homo sapiens 95-107 17629308-1 2007 In this work, surface-enhanced Raman scattering (SERS) was applied to probe the orientation of cytochrome c (Cyt-c) on gold nanohole arrays functionalized with self-assembled monolayers (SAMs) of alkane thiols with positively (-NH2) and negatively (-COOH) charged terminal groups. sers 49-53 cytochrome c, somatic Homo sapiens 109-114 18461904-2 2008 We have employed surface-enhanced Raman scattering (SERS) to obtain insight into the structural details of CARM1 by adsorbing it to silver (Ag) nanoparticles. sers 52-56 coactivator associated arginine methyltransferase 1 Homo sapiens 107-112 18461904-6 2008 In order to confirm the amide vibrations, we have performed SERS on deuterated CARM1, which exhibits a clear red shift in amide band positions. sers 60-64 coactivator associated arginine methyltransferase 1 Homo sapiens 79-84 18461904-7 2008 The SERS spectra may provide useful information, which could be harnessed to study the functional interactions of CARM1 with small molecule modulators. sers 4-8 coactivator associated arginine methyltransferase 1 Homo sapiens 114-119 18341356-1 2008 Nonfluorescent labels were used for an array-format multiplex detection of alternative splice junctions of breast cancer susceptibility gene 1 (BRCA1) by surface-enhanced Raman scattering (SERS). sers 189-193 BRCA1 DNA repair associated Homo sapiens 144-149 18198020-7 2007 Although all spectra were similar, significant differences were detected in the SERS spectra of C4-AHL and 3-oxo-C6-AHL and more subtle differences were noted between all AHLs. sers 80-84 complement C4A (Rodgers blood group) Homo sapiens 96-108 17803330-4 2007 In addition to characterization of the morphological properties, the surface plasmon resonance band, dynamic light scattering, and surface-enhanced Raman scattering (SERS) properties of the MPF-mediated assembly and disassembly processes have been determined. sers 166-170 mesothelin Homo sapiens 190-193 17803330-6 2007 The detection of the Raman-active vibration modes (Ag(2) and Hg(8)) of C60 and the determination of their particle size dependence have demonstrated that the adsorption of MPF on the nanoparticle surface in the MPF-Au nm assembly is responsible for the SERS effect. sers 253-257 mesothelin Homo sapiens 172-175 17803330-6 2007 The detection of the Raman-active vibration modes (Ag(2) and Hg(8)) of C60 and the determination of their particle size dependence have demonstrated that the adsorption of MPF on the nanoparticle surface in the MPF-Au nm assembly is responsible for the SERS effect. sers 253-257 mesothelin Homo sapiens 211-214 17976033-4 2007 We discuss examples of SERS-active nanoparticles used in an assay for PSA, BRCA1 and Her-2, along with examples of nucleic-acid detection. sers 23-27 aminopeptidase puromycin sensitive Homo sapiens 70-73 17976033-4 2007 We discuss examples of SERS-active nanoparticles used in an assay for PSA, BRCA1 and Her-2, along with examples of nucleic-acid detection. sers 23-27 BRCA1 DNA repair associated Homo sapiens 75-80 17976033-4 2007 We discuss examples of SERS-active nanoparticles used in an assay for PSA, BRCA1 and Her-2, along with examples of nucleic-acid detection. sers 23-27 erb-b2 receptor tyrosine kinase 2 Homo sapiens 85-90 17417897-8 2007 Surface-enhanced Raman spectroscopy (SERS) of p300 and the HAT activator complexes evidently suggest that the activation of HAT activity is achieved by the alteration of p300 structure. sers 37-41 E1A binding protein p300 Homo sapiens 170-174 32218711-6 2007 The SERS signal decreased and the fluorescence signal increased when target viral RNA was captured by this molecular beacon probe. sers 4-8 ubiquitin like 5 Homo sapiens 117-123 17298100-7 2007 We demonstrated that SERS-encoded beads could be used for multiplex detection with a model using streptavidin and p53. sers 21-25 tumor protein p53 Homo sapiens 114-117 17288462-3 2007 Specifically, we have used electrochemical methods and surface-enhanced Raman spectroscopy (SERS) to determine whether photo-cross-linked cyt c retains its well-characterized Fe(II/III) heme redox activity. sers 92-96 cytochrome c, somatic Homo sapiens 138-143 16114944-2 2005 It is shown that proteins stabilize and restructure the ASF to increase the SERS signal while preserving antigen-binding activity. sers 76-80 arylsulfatase F Homo sapiens 56-59 16913819-1 2006 We report for the first time the surface-enhanced Raman scattering (SERS) studies on p300, a large multidomain transcriptional coactivator protein. sers 68-72 E1A binding protein p300 Homo sapiens 85-89 16913819-4 2006 This has been confirmed by performing SERS on deuterated p300. sers 38-42 E1A binding protein p300 Homo sapiens 57-61 16913819-7 2006 We have successfully demonstrated the chloride ion effect on the SERS of p300. sers 65-69 E1A binding protein p300 Homo sapiens 73-77 16737206-3 2006 Here, we present a sensitive detection method using surface-enhanced Raman spectroscopy (SERS) that can detect PTMs from as little as zeptomoles of peptide. sers 89-93 parathymosin Homo sapiens 111-115 16737206-6 2006 We further show that it is possible to apply SERS to detect PTMs from biological samples such as histones. sers 45-49 parathymosin Homo sapiens 60-64 16689540-1 2006 A new approach was developed to detect the activity of alkaline phosphatase (ALP) enzyme at ultralow concentrations using a surface-enhanced Raman scattering (SERS) technique. sers 159-163 alkaline phosphatase, placental Homo sapiens 55-75 16689540-1 2006 A new approach was developed to detect the activity of alkaline phosphatase (ALP) enzyme at ultralow concentrations using a surface-enhanced Raman scattering (SERS) technique. sers 159-163 alkaline phosphatase, placental Homo sapiens 77-80 16853609-1 2005 Surface-enhanced Raman spectroscopy (SERS) substrates have been prepared by depositing Au or Ag on porous GaN (PGaN). sers 37-41 gigaxonin Homo sapiens 106-109 16114944-3 2005 Evidence for antibody-antigen binding on the ASF substrates is the distinct SERS spectral changes of the surface-bound antibody or antigen without special tags. sers 76-80 arylsulfatase F Homo sapiens 45-48 15649031-5 2005 These films are shown to be excellent substrates for SERS/SERRS measurements, demonstrating significant enhancement, and trace detection capability. sers 53-57 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 58-63 14697035-7 2004 Finally, the SERS glucose sensor successfully partitions glucose even when challenged with bovine serum albumin, a serum protein mimic. sers 13-17 albumin Homo sapiens 98-111 15606950-3 2004 SERS spectra of pyrene adsorbed to C18-modified immobilized silver colloids are dominated by Raman bands that are not consistent with pyrene and indicate that pyrene undergoes a chemical reaction at the surface. sers 0-4 Bardet-Biedl syndrome 9 Homo sapiens 35-38 11429149-4 2001 In a novel manner, the present study utilized surface-enhanced Raman scattering (SERS) to determine the conformation of vitronectin adsorbed on nanophase alumina. sers 81-85 vitronectin Homo sapiens 120-131 14611786-2 2003 SERS of the SAMs on EAg and/or mAg exhibit SERS effects that vary with etching time and/or deposition time. sers 43-47 potassium voltage-gated channel subfamily H member 1 Homo sapiens 20-23 14611786-2 2003 SERS of the SAMs on EAg and/or mAg exhibit SERS effects that vary with etching time and/or deposition time. sers 43-47 myelin-associated glycoprotein Mus musculus 31-34 14611786-4 2003 Further, a layer of Ag mirror was conveniently deposited on the top of the SAMs on different substrates, yielding a more efficient SERS-active system possessing a "sandwiched" structure of mAgz.sfnc;RAzoCnS-z.sfnc;S. An appropriate surface roughness is required for the strongest SERS effect. sers 131-135 myelin-associated glycoprotein Mus musculus 20-22 14611786-4 2003 Further, a layer of Ag mirror was conveniently deposited on the top of the SAMs on different substrates, yielding a more efficient SERS-active system possessing a "sandwiched" structure of mAgz.sfnc;RAzoCnS-z.sfnc;S. An appropriate surface roughness is required for the strongest SERS effect. sers 280-284 myelin-associated glycoprotein Mus musculus 20-22 14611786-2 2003 SERS of the SAMs on EAg and/or mAg exhibit SERS effects that vary with etching time and/or deposition time. sers 0-4 potassium voltage-gated channel subfamily H member 1 Homo sapiens 20-23 14611786-2 2003 SERS of the SAMs on EAg and/or mAg exhibit SERS effects that vary with etching time and/or deposition time. sers 0-4 myelin-associated glycoprotein Mus musculus 31-34 1711080-14 1991 We conclude that both CP activation by IgM binding to LOS epitopes, one of which contains hexosamine, and ACP activation, which is a function of strain-specific direct binding of properdin, can initiate lysis of sers strains and that ACP activation, also enhances lysis and accounts for variations in sensitivity of sers strains. sers 212-216 complement factor properdin Homo sapiens 179-188 11857273-5 2001 The alpha-helix conformation was concluded to be more favorable as the SERS binding site of bovine serum albumin. sers 71-75 albumin Homo sapiens 99-112 18656098-4 1999 In both groups, SERS significantly decreased platelet aggregation (P<0.05), beta-TG and PF(4) plasma levels (P<0.05). sers 16-20 pro-platelet basic protein Homo sapiens 79-86 9310338-2 1997 The phenotypes associated with the expression of secreted Delta (DlS) or secreted Serrate (SerS) forms mimic loss-of-function mutations in the Notch pathway. sers 91-95 Serrate Drosophila melanogaster 82-89 9310338-3 1997 Both genetic interactions between DlS or SerS transgenics and duplications or loss-of-function mutations of Delta or Serrate indicate that DlS and SerS behave as dominant negative mutations. sers 147-151 Serrate Drosophila melanogaster 117-124 1711080-14 1991 We conclude that both CP activation by IgM binding to LOS epitopes, one of which contains hexosamine, and ACP activation, which is a function of strain-specific direct binding of properdin, can initiate lysis of sers strains and that ACP activation, also enhances lysis and accounts for variations in sensitivity of sers strains. sers 316-320 complement factor properdin Homo sapiens 179-188 34927434-4 2021 Here, we propose a method for actively implementing the photoinduced modulation of SERS signals, which is that under UV irradiation, the Fermi level of graphene can be dynamically modulated due to the adsorption and desorption of gas molecules. sers 83-87 gastrin Homo sapiens 230-233 34624781-5 2022 The reduction in SERS intensity was related to the plasmin activity, and changes in SERS intensity vs. plasmin concentration graph was obtained. sers 17-21 plasminogen Homo sapiens 51-58 34624781-5 2022 The reduction in SERS intensity was related to the plasmin activity, and changes in SERS intensity vs. plasmin concentration graph was obtained. sers 17-21 plasminogen Homo sapiens 103-110 34624781-5 2022 The reduction in SERS intensity was related to the plasmin activity, and changes in SERS intensity vs. plasmin concentration graph was obtained. sers 84-88 plasminogen Homo sapiens 103-110 34980354-5 2022 Au-modified cellulose fibers were used for the detection of p-Mercaptobenzoic acid and Bovine Serum Albumin by the SERS method. sers 115-119 albumin Homo sapiens 94-107 33765221-0 2021 Au/Ag composite-based SERS nanoprobe of Cr3. sers 22-26 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 40-43 33765221-2 2021 Using surface-enhanced Raman scattering (SERS), we construct an Au/Ag composite-based SERS nanoprobe for the quantitative characterization of Cr3+ content in solution, in which DL-mercaptosuccinic acid (DL-MSA) is employed for Raman signal enhancement, and 4-mercaptobenzoic acid (4-MBA) is chosen as the Raman reporter. sers 41-45 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 142-145 33765221-2 2021 Using surface-enhanced Raman scattering (SERS), we construct an Au/Ag composite-based SERS nanoprobe for the quantitative characterization of Cr3+ content in solution, in which DL-mercaptosuccinic acid (DL-MSA) is employed for Raman signal enhancement, and 4-mercaptobenzoic acid (4-MBA) is chosen as the Raman reporter. sers 86-90 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 142-145 33765221-4 2021 Importantly, this Au/Ag composite-based SERS nanoprobe might provide a new strategy for dynamic monitoring of Cr3+ content in human metabolism. sers 40-44 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 110-113 33928988-4 2021 Therefore, this SERS-based aptasensor for the detection of PSA in human blood samples has promising potential to be an alternative tool for clinical application in the accurate screening of prostate cancer. sers 16-20 kallikrein related peptidase 3 Homo sapiens 59-62 34818736-4 2022 Regression analysis in the range from 0.001 to 100 ng mL-1 showed the limit of detection (LOD) being 0.6 pg mL-1 in standard solution, indicating that the great prospects of the AuNP dimers/MXenes SERS substrate for detecting AFB1. sers 197-201 2'-5' oligoadenylate synthetase 1B Mus musculus 54-58 34818736-4 2022 Regression analysis in the range from 0.001 to 100 ng mL-1 showed the limit of detection (LOD) being 0.6 pg mL-1 in standard solution, indicating that the great prospects of the AuNP dimers/MXenes SERS substrate for detecting AFB1. sers 197-201 2'-5' oligoadenylate synthetase 1B Mus musculus 108-112 34635259-4 2022 The acquired SERS spectra of the EPO isoforms showed diagnostic Raman bands that allowed for the discrimination between rhuEPO and enEPO. sers 13-17 erythropoietin Homo sapiens 33-36 34874311-0 2021 Interference-free SERS nanoprobes for labeling and imaging of MT1-MMP in breast cancer cells. sers 18-22 matrix metallopeptidase 14 Homo sapiens 62-69 34957388-0 2022 Identifying infectiousness of SARS-CoV-2 by ultra-sensitive SnS2 SERS biosensors with capillary effect. sers 65-69 sodium voltage-gated channel alpha subunit 11 Homo sapiens 60-64 34957388-2 2022 Here, a micrometer-sized spherical SnS2 structure with the hierarchical nanostructure of "nano-canyon" morphology was developed as semiconductor-based SERS substrate, and it exhibited an extremely low limit of detection of 10-13 M for methylene blue, which is one of the highest sensitivities among the reported pure semiconductor-based SERS substrates. sers 151-155 sodium voltage-gated channel alpha subunit 11 Homo sapiens 35-39 34957388-4 2022 The novel two-step SERS diagnostic route based on the ultra-sensitive SnS2 substrate was presented to diagnose the infectiousness of SARS-CoV-2 through the identification standard of SERS signals for SARS-CoV-2 S protein and RNA, which could accurately identify non-infectious lysed SARS-CoV-2 virions in actual environments, whereas the current PCR methods cannot. sers 19-23 sodium voltage-gated channel alpha subunit 11 Homo sapiens 70-74 34957388-4 2022 The novel two-step SERS diagnostic route based on the ultra-sensitive SnS2 substrate was presented to diagnose the infectiousness of SARS-CoV-2 through the identification standard of SERS signals for SARS-CoV-2 S protein and RNA, which could accurately identify non-infectious lysed SARS-CoV-2 virions in actual environments, whereas the current PCR methods cannot. sers 183-187 sodium voltage-gated channel alpha subunit 11 Homo sapiens 70-74 34957388-2 2022 Here, a micrometer-sized spherical SnS2 structure with the hierarchical nanostructure of "nano-canyon" morphology was developed as semiconductor-based SERS substrate, and it exhibited an extremely low limit of detection of 10-13 M for methylene blue, which is one of the highest sensitivities among the reported pure semiconductor-based SERS substrates. sers 337-341 sodium voltage-gated channel alpha subunit 11 Homo sapiens 35-39 34794563-0 2021 A colorimetric and SERS dual-readout sensor for sensitive detection of tyrosinase activity based on 4-mercaptophenyl boronic acid modified AuNPs. sers 19-23 tyrosinase Homo sapiens 71-81 34794563-6 2021 4-MPBA provides a unique interactive boronic acid group to the diol group of TYR substrate and exhibits good SERS signal. sers 109-113 tyrosinase Homo sapiens 77-80 34794563-8 2021 The TYR-incubated tyramine-modified magnetic beads could obviously change the concentration of 4-MPBA-AuNPs in the presence of O2 and ascorbic acid, where the ultraviolet visible (UV-vis) absorption and SERS intensity were directly related to the concentration of TYR added. sers 203-207 tyrosinase Homo sapiens 4-7 34794563-8 2021 The TYR-incubated tyramine-modified magnetic beads could obviously change the concentration of 4-MPBA-AuNPs in the presence of O2 and ascorbic acid, where the ultraviolet visible (UV-vis) absorption and SERS intensity were directly related to the concentration of TYR added. sers 203-207 tyrosinase Homo sapiens 264-267 34884946-6 2021 This review also explores the applications of the different types of SERS, such as SERRS and SORS, to cancer diagnosis through SERS nanoprobes and the detection of small-size biomarkers, such as exosomes. sers 69-73 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 83-88 34609126-4 2021 In this proof of concept study, we apply our SERS sensor to measure metabolically induced changes in the pHe of carcinoma-derived cell line HepG2/C3A. sers 45-49 complement C3 Homo sapiens 146-149 34957346-3 2021 The current study encompasses the fabrication of a SERS sensor to study the SARS-CoV-2 S1 (RBD) spike protein of the SARS-CoV-2 virus family. sers 51-55 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 96-101 34957346-10 2021 These SiNWs/AgNPs SERS-based sensors were able to detect the spike protein at a concentration down to 9.3 x 10-12 M. Strong and dominant peaks at 1280, 1404, 1495, 1541 and 1609 cm-1 were spotted at a fraction of a minute. sers 18-22 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 61-66 34563978-4 2021 The SERS immunoassay integrates the interference-free Raman response of high wavenumber region (2212 cm-1) and specific capture antibody with high affinity to selectively recognize P-protein from complicated sample. sers 4-8 OCA2 melanosomal transmembrane protein Homo sapiens 181-190 34563978-5 2021 Meanwhile, the target-induced near-field coupling effect between localized surface plasmon resonances of individual SERS immunoprobe and capture substrate enables the detection of P-protein as low as pg/mL level, and the limit of detection can reach 0.329 pg/mL that is about 6 orders of magnitude lower than the limit defined protein residue (causing penicillin allergy). sers 116-120 OCA2 melanosomal transmembrane protein Homo sapiens 180-189 34563978-6 2021 With the ultrasensitivity and specific selectivity, the proposed SERS immunoassay platform can precisely evaluate the content of P-protein in blood sample or penicillin drugs. sers 65-69 OCA2 melanosomal transmembrane protein Homo sapiens 129-138 34111691-3 2021 Under optimized experimental conditions, the SERS sensor demonstrated a linear range of 10-12 to 10-5 g mL-1 for the detection of kanamycin, with a limit of detection of 3.03 x 10-13 g mL-1. sers 45-49 L1 cell adhesion molecule Mus musculus 104-108 34111691-3 2021 Under optimized experimental conditions, the SERS sensor demonstrated a linear range of 10-12 to 10-5 g mL-1 for the detection of kanamycin, with a limit of detection of 3.03 x 10-13 g mL-1. sers 45-49 L1 cell adhesion molecule Mus musculus 185-189 34816331-0 2021 SERS-based immunoassay based on gold nanostars modified with 5,5"-dithiobis-2-nitrobenzoic acid for determination of glial fibrillary acidic protein. sers 0-4 glial fibrillary acidic protein Homo sapiens 117-148 34816331-1 2021 A surface-enhanced Raman scattering (SERS)-based immunoassay with gold nanostars (GNSs) is utilized for determination of the subarachnoid hemorrhage (SAH) biomarker glial fibrillary acidic protein (GFAP) at very low concentration levels, which allows for early diagnosis and guides clinical decision-making to treat SAH-induced complications. sers 37-41 glial fibrillary acidic protein Homo sapiens 165-196 34816331-1 2021 A surface-enhanced Raman scattering (SERS)-based immunoassay with gold nanostars (GNSs) is utilized for determination of the subarachnoid hemorrhage (SAH) biomarker glial fibrillary acidic protein (GFAP) at very low concentration levels, which allows for early diagnosis and guides clinical decision-making to treat SAH-induced complications. sers 37-41 glial fibrillary acidic protein Homo sapiens 198-202 34816331-3 2021 The SERS immunoassay was assembled by SERS tag and GFAP probe-immobilized ITO substrate. sers 4-8 glial fibrillary acidic protein Homo sapiens 51-55 34365287-0 2021 Crown monitoring: Trace the dynamic changes of caspase-3 and H2O2 in real-time imaging based on FRET/SERS. sers 101-105 caspase 3 Homo sapiens 47-56 34364414-6 2021 The biosensor constructed from the SERS substrate with higher sensitivity and lower detection limit (profenofos: 0.0021 ng mL-1; acetamiprid: 0.0046 ng mL-1; carbendazim: 0.0061 ng mL-1). sers 35-39 L1 cell adhesion molecule Mus musculus 123-127 34364414-6 2021 The biosensor constructed from the SERS substrate with higher sensitivity and lower detection limit (profenofos: 0.0021 ng mL-1; acetamiprid: 0.0046 ng mL-1; carbendazim: 0.0061 ng mL-1). sers 35-39 L1 cell adhesion molecule Mus musculus 152-156 34364414-6 2021 The biosensor constructed from the SERS substrate with higher sensitivity and lower detection limit (profenofos: 0.0021 ng mL-1; acetamiprid: 0.0046 ng mL-1; carbendazim: 0.0061 ng mL-1). sers 35-39 L1 cell adhesion molecule Mus musculus 181-185 34364487-0 2021 In-situ SERS readout strategy to improve the reliability of beta-galactosidase activity assay based on X-gal staining in shortening incubation times. sers 8-12 galactosidase beta 1 Homo sapiens 60-78 34549968-3 2021 The interfacial behavior of Cyt c molecules on the TiO2 surface, determined through surface-enhanced Raman scattering (SERS), is extremely affected by the ionic strength of the solution as the ion dissociation and hydration also increase the electron transfer ability, where the best SERS enhancement is observed at the ionic strength of around 1.0 M, corresponding to the largest molecular force. sers 119-123 cytochrome c, somatic Homo sapiens 28-33 34134070-0 2021 Ultrasensitive detection of SARS-CoV-2 spike protein in untreated saliva using SERS-based biosensor. sers 79-83 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 39-44 34134070-4 2021 The detection was performed by an immunoreaction between the SARS-CoV-2 spike antibody modified SERS-immune substrate, spike antigen protein and Raman reporter-labeled immuno-Ag nanoparticles. sers 96-100 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 72-77 34134070-5 2021 This SERS-based biosensor was able to detect the SARS-CoV-2 spike protein at concentrations of 0.77 fg mL-1 in phosphate-buffered saline and 6.07 fg mL-1 in untreated saliva. sers 5-9 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 60-65 34134070-5 2021 This SERS-based biosensor was able to detect the SARS-CoV-2 spike protein at concentrations of 0.77 fg mL-1 in phosphate-buffered saline and 6.07 fg mL-1 in untreated saliva. sers 5-9 L1 cell adhesion molecule Mus musculus 103-107 34134070-5 2021 This SERS-based biosensor was able to detect the SARS-CoV-2 spike protein at concentrations of 0.77 fg mL-1 in phosphate-buffered saline and 6.07 fg mL-1 in untreated saliva. sers 5-9 L1 cell adhesion molecule Mus musculus 149-153 34677336-6 2021 SERS performance of the microshells at very low 0.4 microW laser power was probed using rhodamine B and bovine serum albumin showing enhancement factors of 2 x 108 and 8 x 108, respectively. sers 0-4 albumin Homo sapiens 111-124 34549968-3 2021 The interfacial behavior of Cyt c molecules on the TiO2 surface, determined through surface-enhanced Raman scattering (SERS), is extremely affected by the ionic strength of the solution as the ion dissociation and hydration also increase the electron transfer ability, where the best SERS enhancement is observed at the ionic strength of around 1.0 M, corresponding to the largest molecular force. sers 284-288 cytochrome c, somatic Homo sapiens 28-33 34685003-4 2021 We analyzed how they interact with proteins after pre-incubation with bovine serum albumin (BSA) via UV-Vis, DLS, ZP, NTA, SERS, cryogenic TEM (cryo-TEM) and circular dichroism (CD) spectroscopy. sers 123-127 albumin Homo sapiens 77-90 34491043-5 2021 To improve selectivity in complex biological environments, we have employed peptides as capture probes for viral proteins and developed an angiotensin-converting enzyme 2 (ACE2) mimetic peptide-based SERS sensor for SARS-CoV-2. sers 200-204 angiotensin converting enzyme 2 Homo sapiens 139-170 34436857-4 2021 As a result, the carbonyl peak (nuC O) resolved in the SERS spectrum includes the contributions from those anchored to the surface and those residing on the loops, with their frequencies located at nuC O(Ag) and nuC O(free), respectively. sers 55-59 nucleobindin 1 Homo sapiens 32-35 34436857-4 2021 As a result, the carbonyl peak (nuC O) resolved in the SERS spectrum includes the contributions from those anchored to the surface and those residing on the loops, with their frequencies located at nuC O(Ag) and nuC O(free), respectively. sers 55-59 nucleobindin 1 Homo sapiens 198-201 34436857-4 2021 As a result, the carbonyl peak (nuC O) resolved in the SERS spectrum includes the contributions from those anchored to the surface and those residing on the loops, with their frequencies located at nuC O(Ag) and nuC O(free), respectively. sers 55-59 nucleobindin 1 Homo sapiens 212-215 34491043-5 2021 To improve selectivity in complex biological environments, we have employed peptides as capture probes for viral proteins and developed an angiotensin-converting enzyme 2 (ACE2) mimetic peptide-based SERS sensor for SARS-CoV-2. sers 200-204 angiotensin converting enzyme 2 Homo sapiens 172-176 34074427-2 2021 A SERS immuno-tag fabricated by decorating silver nanoparticles (AgNPs) with a specific antibody was employed to trace the dynamic expression of the tumor metastasis-related N-cadherin. sers 2-6 cadherin 2 Homo sapiens 174-184 34382625-5 2021 The SERS spectra of serum albumin obtained from three sample groups were analyzed to verify the feasibility of this new method: healthy volunteers (n = 35), LC patients with T1 stage (n = 25) and LC patients with T2-T4 stage (n = 23). sers 4-8 albumin Homo sapiens 26-33 34247742-0 2021 Fabrication of large size individual octahedral tungsten oxide hydrate and Au NPs as SERS platforms for sensitive detection of cytochrome C. sers 85-89 cytochrome c, somatic Homo sapiens 127-139 34483659-8 2021 Using this biofunctionalized SERS substrate, we detected varying concentrations of MMP-9 (10-5000 ng/mL) and TNF-alpha (5-100 ng/mL) proteins to model the wound exudates. sers 29-33 matrix metallopeptidase 9 Homo sapiens 83-88 34483659-8 2021 Using this biofunctionalized SERS substrate, we detected varying concentrations of MMP-9 (10-5000 ng/mL) and TNF-alpha (5-100 ng/mL) proteins to model the wound exudates. sers 29-33 tumor necrosis factor Homo sapiens 109-118 34483659-9 2021 This SERS detection method demonstrates a linear response within biologically relevant concentrations, ranging from 10 to 500 ng/mL for MMP-9 and 5 to 25 ng/mL for TNF-alpha for these surrogate indicators. sers 5-9 matrix metallopeptidase 9 Homo sapiens 136-141 34483659-9 2021 This SERS detection method demonstrates a linear response within biologically relevant concentrations, ranging from 10 to 500 ng/mL for MMP-9 and 5 to 25 ng/mL for TNF-alpha for these surrogate indicators. sers 5-9 tumor necrosis factor Homo sapiens 164-173 34443894-5 2021 The SERS signal intensity exhibits an exponential enhancement with increasing Nd doping concentration and reaches its optimum at 2%, which is attributed to two factors: (1) The increase in the defect concentration is beneficial to the CT process between the TiO2 and the probe molecule; (2) the introduction of 4f electron orbital energy levels of rare-earth ions created unique CT process between Nd3+ and 4-Mpy. sers 4-8 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 398-401 34348462-4 2021 A nanoflower-shaped SERS-tag, constituted of hybrid gold nanostar with silver tips to achieve maximum fingerprint enhancement from the incorporated reporter molecule, was further functionalized with the cocktail monoclonal antibodies against p16/K-i67. sers 20-24 cyclin dependent kinase inhibitor 2A Homo sapiens 242-245 34450988-0 2021 SERS Gas Sensors Based on Multiple Polymer Films with High Design Flexibility for Gas Recognition. sers 0-4 gastrin Homo sapiens 5-8 34450988-0 2021 SERS Gas Sensors Based on Multiple Polymer Films with High Design Flexibility for Gas Recognition. sers 0-4 gastrin Homo sapiens 82-85 34450988-2 2021 However, gases with similar molecular structures are difficult to directly discriminate using SERS gas sensors because there are characteristic peak overlaps in the Raman spectra. sers 94-98 gastrin Homo sapiens 99-102 34450988-3 2021 Here, we proposed a multiple SERS gas sensor matrix via a spin-coating functional polymer to enhance the gas recognition capability. sers 29-33 gastrin Homo sapiens 34-37 34450988-3 2021 Here, we proposed a multiple SERS gas sensor matrix via a spin-coating functional polymer to enhance the gas recognition capability. sers 29-33 gastrin Homo sapiens 105-108 34450988-6 2021 The SERS gas sensor coated by different polymer films showed a distinct affinity to target gases. sers 4-8 gastrin Homo sapiens 9-12 34451009-6 2021 The main SERS peaks of TNT, RDX, and PETN were clearly observed down to the order of picomolar concentration. sers 9-13 chromosome 16 open reading frame 82 Homo sapiens 23-26 34331134-0 2021 SERS-ELISA determination of human carboxylesterase 1 using metal-organic framework doped with gold nanoparticles as SERS substrate. sers 0-4 carboxylesterase 1 Homo sapiens 34-52 34331134-0 2021 SERS-ELISA determination of human carboxylesterase 1 using metal-organic framework doped with gold nanoparticles as SERS substrate. sers 116-120 carboxylesterase 1 Homo sapiens 34-52 34331134-6 2021 On this basis, we developed a method for the detection of human carboxylesterase 1 (hCE 1) in human serum using AuNP/AE-MIL-101 (Cr) nanocomposite as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as SERS marker. sers 150-154 carboxylesterase 1 Homo sapiens 64-82 34263277-2 2021 When using DFT to simulate SERS on a silver surface, one typically employs an atom (Ag), ion (Ag+), or cluster (Agx or Agx+) as the model surface. sers 27-31 UDP-N-acetylglucosamine pyrophosphorylase 1 Homo sapiens 112-115 34331134-6 2021 On this basis, we developed a method for the detection of human carboxylesterase 1 (hCE 1) in human serum using AuNP/AE-MIL-101 (Cr) nanocomposite as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as SERS marker. sers 237-241 carboxylesterase 1 Homo sapiens 64-82 34331134-6 2021 On this basis, we developed a method for the detection of human carboxylesterase 1 (hCE 1) in human serum using AuNP/AE-MIL-101 (Cr) nanocomposite as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as SERS marker. sers 237-241 carboxylesterase 1 Homo sapiens 84-89 34331134-8 2021 In the concentration range 0.1-120 ng mL-1, the SERS signal intensity of benzidine at 1609 cm-1 gradually decreases with the increase of hCE 1 concentration (R2 = 0.9948). sers 48-52 L1 cell adhesion molecule Mus musculus 38-42 34331134-8 2021 In the concentration range 0.1-120 ng mL-1, the SERS signal intensity of benzidine at 1609 cm-1 gradually decreases with the increase of hCE 1 concentration (R2 = 0.9948). sers 48-52 carboxylesterase 1 Homo sapiens 137-142 34331134-10 2021 By using AuNP/acid etching-MIL-101(Cr) metal organic framework (MOF) as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as the SERS marker, a rapid and sensitive method for the determination of human carboxylesterase 1 (hCE1) in human serum samples has been developed. sers 72-76 carboxylesterase 1 Homo sapiens 236-254 34331134-10 2021 By using AuNP/acid etching-MIL-101(Cr) metal organic framework (MOF) as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as the SERS marker, a rapid and sensitive method for the determination of human carboxylesterase 1 (hCE1) in human serum samples has been developed. sers 163-167 carboxylesterase 1 Homo sapiens 236-254 34331134-10 2021 By using AuNP/acid etching-MIL-101(Cr) metal organic framework (MOF) as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as the SERS marker, a rapid and sensitive method for the determination of human carboxylesterase 1 (hCE1) in human serum samples has been developed. sers 163-167 carboxylesterase 1 Homo sapiens 256-260 34263277-2 2021 When using DFT to simulate SERS on a silver surface, one typically employs an atom (Ag), ion (Ag+), or cluster (Agx or Agx+) as the model surface. sers 27-31 UDP-N-acetylglucosamine pyrophosphorylase 1 Homo sapiens 119-122 34263277-3 2021 Here, by examining the nucleobase 2,6-diaminopurine (2,6-DAP) and then generalising our strategy to three other molecules, we show that employing silver oxide (Ag2O) as the model surface can quantitatively improve the accuracy of simulated SERS. sers 240-244 death associated protein Homo sapiens 57-60 34110178-1 2021 A simple and reproducible surface enhanced Raman scattering (SERS) substrate of bimetallic gold-silver (Au-Ag) based on discarded a Blu-ray disc read only memory (BD-ROM) was developed by simply incorporating electrochemical (EC) treatment and chemical reaction. sers 61-65 zinc finger MYND-type containing 10 Homo sapiens 132-135 34137769-6 2021 With distinct surface functionalities from JRCPCs, SERS-based quantitative analysis of CEA is achieved using JRCPCs as SERS nanoprobes. sers 51-55 CEA cell adhesion molecule 3 Homo sapiens 87-90 34137769-6 2021 With distinct surface functionalities from JRCPCs, SERS-based quantitative analysis of CEA is achieved using JRCPCs as SERS nanoprobes. sers 119-123 CEA cell adhesion molecule 3 Homo sapiens 87-90 34381960-6 2021 Importantly, the aggregated gold nanoparticles form "hot spots" to provide very strong SERS signal enhancement from anti-spike antibody and 4-aminothiophenol attached gold nanoparticles via light-matter interactions. sers 87-91 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 121-126 34198765-3 2021 Herein, we proposed a lateral flow assay (LFA) strip based on surface-enhanced Raman scattering (SERS) nanotags (SERS-LFA strips) for the simultaneous and quantitative detection of dual infection biomarkers, serum amyloid A (SAA) and C-reactive protein (CRP), respectively. sers 113-117 serum amyloid A1 cluster Homo sapiens 208-223 34198765-3 2021 Herein, we proposed a lateral flow assay (LFA) strip based on surface-enhanced Raman scattering (SERS) nanotags (SERS-LFA strips) for the simultaneous and quantitative detection of dual infection biomarkers, serum amyloid A (SAA) and C-reactive protein (CRP), respectively. sers 113-117 serum amyloid A1 cluster Homo sapiens 225-228 34198765-3 2021 Herein, we proposed a lateral flow assay (LFA) strip based on surface-enhanced Raman scattering (SERS) nanotags (SERS-LFA strips) for the simultaneous and quantitative detection of dual infection biomarkers, serum amyloid A (SAA) and C-reactive protein (CRP), respectively. sers 113-117 C-reactive protein Homo sapiens 234-252 34198765-3 2021 Herein, we proposed a lateral flow assay (LFA) strip based on surface-enhanced Raman scattering (SERS) nanotags (SERS-LFA strips) for the simultaneous and quantitative detection of dual infection biomarkers, serum amyloid A (SAA) and C-reactive protein (CRP), respectively. sers 113-117 C-reactive protein Homo sapiens 254-257 35588604-5 2022 The Pd-HRG is employed to modify fluorine doped tin oxide electrode (Pd-HRG/FTO), resulted with an enhancement factor of 7.5 x 104 corresponding to the EC-SERS technique. sers 155-159 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 76-79 35413530-5 2022 The Raman signal of NFX is largely enhanced when anchored by beta-CD on the surface of AgNPs due to SERS effect. sers 100-104 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 61-68 35419693-0 2022 DNAzyme signal amplification based on Au@Ag core-shell nanorods for highly sensitive SERS sensing miRNA-21. sers 85-89 microRNA 21 Homo sapiens 98-106 35325718-4 2022 Here, we present a sensitive ratio-type SERS nanoprobe for imaging of matrix metalloproteinase-2 (MMP-2) in different cancer cells subtypes. sers 40-44 matrix metallopeptidase 2 Homo sapiens 70-96 35325718-4 2022 Here, we present a sensitive ratio-type SERS nanoprobe for imaging of matrix metalloproteinase-2 (MMP-2) in different cancer cells subtypes. sers 40-44 matrix metallopeptidase 2 Homo sapiens 98-103 35325718-6 2022 MMP-2-responsive cleavage of peptides from the nanoprobe surface results in decrease or even disappearance of SERS emission of Rh B, which was ratioed over the emission of 2-NT for the quantification of MMP-2 activity. sers 110-114 matrix metallopeptidase 2 Homo sapiens 0-5 35612288-4 2022 Through the hybridization-based recognition effect, we observe an enormous SERS signal enhancement caused by miRNA-21-triggered assembly of core-satellite nanocomposites. sers 75-79 microRNA 21 Homo sapiens 109-117 35419693-2 2022 The as-prepared SERS nanoprobes were composed of a thiol-modification hairpin probe (HP2)-functionalized Au@Ag NRs and hairpin DNAzyme (HP1-Dz). sers 16-20 chromobox 5 Homo sapiens 136-139 35419693-4 2022 In the presence of target miRNAs, the hairpin construction of HP1-Dz changed due to DNA/RNA hybridization; subsequently, the DNAzyme-catalyzed cleaving process changed, and the Raman signals of the SERS nanoprobes gradually "turned off" with time elapse because of the dissociation of the Raman reporter from the surface of Au@Ag NRs. sers 198-202 chromobox 5 Homo sapiens 62-65 35419693-5 2022 Hence, based on this principle, the proposed SERS sensor exhibited good linearity in the range 0.5 fM to 10 nM for miRNA-21 detection with a detection limit (LOD) of 0.5 fM. sers 45-49 microRNA 21 Homo sapiens 115-123 35419693-6 2022 The proposed SERS platform has potential application in quantitative and precise detection of miRNA-21 in human serum. sers 13-17 microRNA 21 Homo sapiens 94-102 35419693-1 2022 Here, we developed a surface-enhanced Raman scattering (SERS) sensor based on functionalized Au@Ag core-shell nanorods (Au@Ag NRs) and cascade DNAzyme amplifier (CSA) for sensitive and accurate determination of microRNA-21 (miRNA-21). sers 56-60 microRNA 21 Homo sapiens 211-222 35419693-1 2022 Here, we developed a surface-enhanced Raman scattering (SERS) sensor based on functionalized Au@Ag core-shell nanorods (Au@Ag NRs) and cascade DNAzyme amplifier (CSA) for sensitive and accurate determination of microRNA-21 (miRNA-21). sers 56-60 microRNA 21 Homo sapiens 224-232 35536049-5 2022 Then, AA could reduce Cu(II) to produce Cu(I), which plays the role of a catalyst to promote the click reaction of azide terephthalic acid (ATA) and 4-acetylene biphenyl (4-AB), resulting in the SERS signal intensity of free 4-AB in the solution was clearly reduced along with the click reaction carried on, and showed a quantitative relationship with the concentration of ALP. sers 195-199 alkaline phosphatase, placental Homo sapiens 373-376 35235898-5 2022 This 3D SERS biosensor achieved ~10 aM detection limits for the target miRNAs (miR-10a and miR-21), which is over 1000-fold more sensitive than previously reported miRNA sensors without the requirement of any labelling or pre-treatment steps. sers 8-12 microRNA 10a Homo sapiens 79-86 35235898-5 2022 This 3D SERS biosensor achieved ~10 aM detection limits for the target miRNAs (miR-10a and miR-21), which is over 1000-fold more sensitive than previously reported miRNA sensors without the requirement of any labelling or pre-treatment steps. sers 8-12 microRNA 21 Homo sapiens 91-97 35536049-7 2022 As a proof of concept, the new developed SERS-click strategy was applied to the specific determination of the ALP activity in clinical serum samples, cellular lysate samples and the ALP inhibitor assessment successfully, indicating that the proposed ALP-triggered click chemistry assay has a significant potential application in medical diagnosis. sers 41-45 alkaline phosphatase, placental Homo sapiens 110-113 35536049-7 2022 As a proof of concept, the new developed SERS-click strategy was applied to the specific determination of the ALP activity in clinical serum samples, cellular lysate samples and the ALP inhibitor assessment successfully, indicating that the proposed ALP-triggered click chemistry assay has a significant potential application in medical diagnosis. sers 41-45 alkaline phosphatase, placental Homo sapiens 182-185 35289177-0 2022 Charge-Transfer Resonance and Surface Defect-Dominated WO3 Hollow Microspheres as SERS Substrates for the miRNA 155 Assay. sers 82-86 microRNA 155 Homo sapiens 106-115 35289177-6 2022 Finally, a SERS biosensor is constructed based on the above-mentioned semiconductor materials, which can be used for the sensitive detection of miRNA 155 with a limit of detection (LOD) of 0.18 fM by employing a catalytic hairpin assembly (CHA) strategy. sers 11-15 microRNA 155 Homo sapiens 144-153 35209305-0 2022 Simultaneous and ultra-sensitive SERS detection of SLPI and IL-18 for the assessment of donor kidney quality using black phosphorus/gold nanohybrids. sers 33-37 secretory leukocyte peptidase inhibitor Homo sapiens 51-55 35038640-3 2022 Through fabricating 4-MPA antibody-modified AgNPs on the lateral flow assay (LFA) strips as the SERS nanotags, the target proteins in blood samples from pregnancy were accurately captured, which further quantizing PI3K and CRAF in unprocessed blood. sers 96-100 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 223-227 35271769-0 2022 Rapid, Point-of-Care scFv-SERS Assay for Femtogram Level Detection of SARS-CoV-2. sers 26-30 immunglobulin heavy chain variable region Homo sapiens 21-25 35258921-3 2022 The effects of the size and density of Au TOH on the SERS performance were investigated by experiments and simulations, which showed that the maximum SERS enhancement was obtained for Au TOH with the size of 75 nm when particle density reached 74.54 counts/mum2. sers 53-57 trafficking protein particle complex subunit 1 Homo sapiens 257-261 35258921-3 2022 The effects of the size and density of Au TOH on the SERS performance were investigated by experiments and simulations, which showed that the maximum SERS enhancement was obtained for Au TOH with the size of 75 nm when particle density reached 74.54 counts/mum2. sers 150-154 trafficking protein particle complex subunit 1 Homo sapiens 257-261 35313446-9 2022 A SNSF-containing SERS substrate, fabricated from SNSF and filter paper, was used to sense redox activity in cancer cell lines and to further identify correlations between redox activity and cancer cell line aggressiveness, as indicated by the use of EpCAM as a biomarker. sers 18-22 epithelial cell adhesion molecule Homo sapiens 251-256 35223986-3 2021 Herein, we developed a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC). sers 58-62 microRNA 106b Homo sapiens 207-215 35223986-3 2021 Herein, we developed a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC). sers 58-62 microRNA 196b Homo sapiens 220-228 35214929-0 2022 Graphene Oxide/Silver Nanoparticles Platforms for the Detection and Discrimination of Native and Fibrillar Lysozyme: A Combined QCM and SERS Approach. sers 136-140 lysozyme Homo sapiens 107-115 35214929-5 2022 SERS experiments performed on arrays of bare AgNPs and of GO coated AgNP after native, or fibrillar, lysozyme adsorption allowed for the discrimination of the native form and toxic fibrillar structure of lysozyme. sers 0-4 lysozyme Homo sapiens 101-109 35214929-5 2022 SERS experiments performed on arrays of bare AgNPs and of GO coated AgNP after native, or fibrillar, lysozyme adsorption allowed for the discrimination of the native form and toxic fibrillar structure of lysozyme. sers 0-4 lysozyme Homo sapiens 204-212 35214929-6 2022 Results from combined QCM/SERS studies indicate a general construction paradigm for an efficient sensing platform with high selectivity and low detection limit for native and amyloid lysozyme. sers 26-30 lysozyme Homo sapiens 183-191 35048911-0 2022 Electrostimulus-associated PD-L1 expression on cell membrane revealed by immune SERS nanoprobes. sers 80-84 CD274 molecule Homo sapiens 27-32 35081679-2 2022 However, it remains challenging for SERS-based biosensors using a sandwiching strategy to detect long-chain nucleic acids such as nucleocapsid (N) gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because the extension of the coupling distance (CD) between the two tethered metallic nanostructures weakens electric field and SERS signals. sers 36-40 nucleocapsid phosphoprotein Severe acute respiratory syndrome coronavirus 2 130-142 35081679-2 2022 However, it remains challenging for SERS-based biosensors using a sandwiching strategy to detect long-chain nucleic acids such as nucleocapsid (N) gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because the extension of the coupling distance (CD) between the two tethered metallic nanostructures weakens electric field and SERS signals. sers 36-40 nucleocapsid phosphoprotein Severe acute respiratory syndrome coronavirus 2 144-145 35081679-2 2022 However, it remains challenging for SERS-based biosensors using a sandwiching strategy to detect long-chain nucleic acids such as nucleocapsid (N) gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because the extension of the coupling distance (CD) between the two tethered metallic nanostructures weakens electric field and SERS signals. sers 344-348 nucleocapsid phosphoprotein Severe acute respiratory syndrome coronavirus 2 130-142 35081679-2 2022 However, it remains challenging for SERS-based biosensors using a sandwiching strategy to detect long-chain nucleic acids such as nucleocapsid (N) gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because the extension of the coupling distance (CD) between the two tethered metallic nanostructures weakens electric field and SERS signals. sers 344-348 nucleocapsid phosphoprotein Severe acute respiratory syndrome coronavirus 2 144-145 35209305-0 2022 Simultaneous and ultra-sensitive SERS detection of SLPI and IL-18 for the assessment of donor kidney quality using black phosphorus/gold nanohybrids. sers 33-37 interleukin 18 Homo sapiens 60-65 35209305-8 2022 Quantitative detection of SLPI and IL-18 were then achieved by characterizing SERS signals of these two biomarkers. sers 78-82 secretory leukocyte peptidase inhibitor Homo sapiens 26-30 35209305-14 2022 Giving that the combined assessment of SLPI and IL-18 expression level serves as an indicator of donor kidney quality and can be rapidly and reproducibly conducted, this SERS-based method holds great prospective in clinical practice. sers 170-174 secretory leukocyte peptidase inhibitor Homo sapiens 39-43 35209305-14 2022 Giving that the combined assessment of SLPI and IL-18 expression level serves as an indicator of donor kidney quality and can be rapidly and reproducibly conducted, this SERS-based method holds great prospective in clinical practice. sers 170-174 interleukin 18 Homo sapiens 48-53