PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16820034-10	2006	Tianeptine treatment of OB rats significantly inhibited peridodontal bone loss, normalized behavioural responses, enhanced TGF-1beta levels, and abolished TNF-alpha decrease, but did not attenuate the increased corticosterone response and the decreased hippocampal GR expression.	tianeptine	0-10	tumor necrosis factor	Rattus norvegicus	155-164
18657555-8	2009	Tianeptine, but not imipramine, increased the phosphorylation of Ser831-GluA1.	tianeptine	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
18657555-9	2009	Altogether, these results indicate that acute elevated platform stress down-regulates a putative BDNF/MEK/MAPK signaling cascade in the frontal cortex in a manner that is reversible by the antidepressants tianeptine and imipramine.	tianeptine	205-215	brain-derived neurotrophic factor	Rattus norvegicus	97-101
18657555-12	2009	Tianeptine, but not imipramine, increased the phosphorylation of Ser831-GluA1, indicating a potential effect on AMPA receptor phosphorylation being involved in the reversal of LTP.	tianeptine	0-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	72-77
18088278-4	2007	Here, it was found that treatment with another antidepressant, tianeptine, increased P-Ser831-GluR1 in the frontal cortex and the CA3 region of hippocampus and P-Ser845-GluR1 in the CA3 region of hippocampus.	tianeptine	63-73	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	94-99
18088278-4	2007	Here, it was found that treatment with another antidepressant, tianeptine, increased P-Ser831-GluR1 in the frontal cortex and the CA3 region of hippocampus and P-Ser845-GluR1 in the CA3 region of hippocampus.	tianeptine	63-73	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	169-174
18088278-8	2007	P-Ser133-CREB was reduced in the CA3 region of hippocampus in phosphomutant mice, and tianeptine decreased P-Ser133-CREB in this region in wild-type, but not in phosphomutant, mice.	tianeptine	86-96	cAMP responsive element binding protein 1	Mus musculus	107-120
18088278-9	2007	Tianeptine increased P-Ser133-CREB in the CA1 region in wild-type mice but not in phosphomutant GluR1 mice.	tianeptine	0-10	cAMP responsive element binding protein 1	Mus musculus	21-34
18088278-10	2007	There were higher basal P-Ser133-CREB and c-fos levels in frontal and cingulate cortex in phosphomutant GluR1 mice; these changes in level were counteracted by tianeptine in a GluR1-independent manner.	tianeptine	160-170	FBJ osteosarcoma oncogene	Mus musculus	42-47
18088278-10	2007	There were higher basal P-Ser133-CREB and c-fos levels in frontal and cingulate cortex in phosphomutant GluR1 mice; these changes in level were counteracted by tianeptine in a GluR1-independent manner.	tianeptine	160-170	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	104-109
18088278-10	2007	There were higher basal P-Ser133-CREB and c-fos levels in frontal and cingulate cortex in phosphomutant GluR1 mice; these changes in level were counteracted by tianeptine in a GluR1-independent manner.	tianeptine	160-170	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	176-181
17368617-0	2007	Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala.	tianeptine	0-10	brain-derived neurotrophic factor	Rattus norvegicus	21-54
17368617-8	2007	Conversely, BDNF mRNA levels were increased in the amygdala of chronic restraint stress/tianeptine rats in the absence of changes in pCREB levels when compared to non-stressed controls.	tianeptine	88-98	brain-derived neurotrophic factor	Rattus norvegicus	12-16
17368617-9	2007	Amygdalar BDNF protein increased while pCREB levels decreased in tianeptine-treated rats irrespective of stress conditions.	tianeptine	65-75	brain-derived neurotrophic factor	Rattus norvegicus	10-14
17368617-10	2007	Collectively, these results demonstrate that tianeptine concomitantly decreases pCREB while increasing BDNF expression in the rat amygdala, increases in neurotrophic factor expression that may participate in the enhancement of amygdalar synaptic plasticity mediated by tianeptine.	tianeptine	45-55	brain-derived neurotrophic factor	Rattus norvegicus	103-107
17368617-10	2007	Collectively, these results demonstrate that tianeptine concomitantly decreases pCREB while increasing BDNF expression in the rat amygdala, increases in neurotrophic factor expression that may participate in the enhancement of amygdalar synaptic plasticity mediated by tianeptine.	tianeptine	45-55	neurotrophin 3	Rattus norvegicus	153-172
16753931-5	2006	Tianeptine blocked the stress-induced suppression of PB potentiation in CA1 without affecting the stress-induced enhancement of LTP in BLA.	tianeptine	0-10	carbonic anhydrase 1	Rattus norvegicus	72-75
16409252-8	2006	Also the tianeptine-treated rats showed significantly reduced periodontal bone loss (p=0.01), enhanced plasma levels of TNF-alpha (p < 0.05), and transforming growth factor-1beta (p < 0.01), whereas no significant difference was found in corticosterone levels.	tianeptine	9-19	tumor necrosis factor	Rattus norvegicus	120-129
16388118-6	2005	Some antidepressant drugs, such as tianeptine, which were found to modulate ACTH release, appear to interfere with brain glutamatergic system.	tianeptine	35-45	proopiomelanocortin	Homo sapiens	76-80
16300628-3	2006	We found that the serotonin modulators fluoxetine and tianeptine, but not desipramine, increase the density of 5-HT and serotonin transporter (SERT)-immunoreactive axons in the neocortical layer IV and certain forebrain limbic areas, such as piriform cortex and the shell region of nucleus accumbens.	tianeptine	54-64	solute carrier family 6 member 4	Homo sapiens	120-141
16300628-3	2006	We found that the serotonin modulators fluoxetine and tianeptine, but not desipramine, increase the density of 5-HT and serotonin transporter (SERT)-immunoreactive axons in the neocortical layer IV and certain forebrain limbic areas, such as piriform cortex and the shell region of nucleus accumbens.	tianeptine	54-64	solute carrier family 6 member 4	Homo sapiens	143-147
17117674-7	2006	Unlike sertraline, coaxil caused an increase of this parameter in patients with decreased DHEA-S level.	tianeptine	19-25	sulfotransferase family 2A member 1	Homo sapiens	90-96
17117674-8	2006	The ratio cortisol/ DHEA-S decreased during the treatment with either coaxil or sertraline but in the former case it was more pronounced (p = 0.003).	tianeptine	70-76	sulfotransferase family 2A member 1	Homo sapiens	20-26
14766991-0	2004	Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine.	tianeptine	108-118	solute carrier family 1 member 2	Rattus norvegicus	38-43
14735130-6	2004	It was found that imipramine, amitryptyline, desipramine, fluoxetine, and mianserin, present in the culture medium for 5 days, in a concentration-dependent manner inhibited basal hCRH gene promoter activity in undifferentiated Neuro-2A cells, while other drugs under study (citalopram, tianeptine, moclobemide, venlafaxine, reboxetine, mirtazapine, and milnacipram) were inactive.	tianeptine	286-296	corticotropin releasing hormone	Homo sapiens	179-183
14735130-7	2004	In the differentiated cells, all examined antidepressants, except moclobemide (no effect) and tianeptine (increase), inhibited hCRH gene transcription.	tianeptine	94-104	corticotropin releasing hormone	Homo sapiens	127-131
14766991-5	2004	CRS increased GLT-1 mRNA expression in the dentate gyrus and CA3 region of Ammon"s horn, increases that were inhibited by tianeptine.	tianeptine	122-132	solute carrier family 1 member 2	Rattus norvegicus	14-19
14766991-5	2004	CRS increased GLT-1 mRNA expression in the dentate gyrus and CA3 region of Ammon"s horn, increases that were inhibited by tianeptine.	tianeptine	122-132	carbonic anhydrase 3	Rattus norvegicus	61-64
14766991-6	2004	CRS more selectively increased GLT-1 protein levels in the subregion where dendritic remodeling is most prominent, namely the CA3 region, increases that were also inhibited by tianeptine administration.	tianeptine	176-186	solute carrier family 1 member 2	Rattus norvegicus	31-36
14766991-6	2004	CRS more selectively increased GLT-1 protein levels in the subregion where dendritic remodeling is most prominent, namely the CA3 region, increases that were also inhibited by tianeptine administration.	tianeptine	176-186	carbonic anhydrase 3	Rattus norvegicus	126-129
14766991-8	2004	These results point to the importance of understanding the mechanism for the differential and subregional regulation of GLT-1 isoforms in neuronal and glial compartments in the hippocampus as a basis for understanding the effects of chronic stress on structural plasticity as well as the neuroprotective properties of agents such as tianeptine.	tianeptine	333-343	solute carrier family 1 member 2	Rattus norvegicus	120-125
15110927-7	2004	Chronic tianeptine treatment attenuated LPS-induced expression of TNF-alpha in the spleen as well as plasma levels of this cytokine and altered the central balance between pro- and anti-inflammatory cytokines (IL-1 beta/IL-10).	tianeptine	8-18	tumor necrosis factor	Rattus norvegicus	66-75
15110927-7	2004	Chronic tianeptine treatment attenuated LPS-induced expression of TNF-alpha in the spleen as well as plasma levels of this cytokine and altered the central balance between pro- and anti-inflammatory cytokines (IL-1 beta/IL-10).	tianeptine	8-18	interleukin 1 beta	Rattus norvegicus	210-219
15110927-7	2004	Chronic tianeptine treatment attenuated LPS-induced expression of TNF-alpha in the spleen as well as plasma levels of this cytokine and altered the central balance between pro- and anti-inflammatory cytokines (IL-1 beta/IL-10).	tianeptine	8-18	interleukin 10	Rattus norvegicus	220-225
14766991-4	2004	We also examined the ability of the antidepressant tianeptine, which blocks CRS-induced dendritic remodeling, to modulate CRS-mediated changes in GLT-1 and GLT-1b expression.	tianeptine	51-61	solute carrier family 1 member 2	Rattus norvegicus	146-151
14766991-4	2004	We also examined the ability of the antidepressant tianeptine, which blocks CRS-induced dendritic remodeling, to modulate CRS-mediated changes in GLT-1 and GLT-1b expression.	tianeptine	51-61	solute carrier family 1 member 2	Rattus norvegicus	146-149
12829995-5	2003	In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B).	tianeptine	75-85	microsomal triglyceride transfer protein	Mus musculus	118-121
12829995-5	2003	In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B).	tianeptine	75-85	microsomal triglyceride transfer protein	Mus musculus	159-162
12829995-5	2003	In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B).	tianeptine	75-85	apolipoprotein B	Mus musculus	356-361
12681378-3	2003	However, tianeptine did not block apoptosis in cultured cortical neurones caused by NMDA, but reduced apoptosis when interleukin-1beta (IL-1beta) was included with NMDA.	tianeptine	9-19	interleukin 1 beta	Mus musculus	117-134
12681378-3	2003	However, tianeptine did not block apoptosis in cultured cortical neurones caused by NMDA, but reduced apoptosis when interleukin-1beta (IL-1beta) was included with NMDA.	tianeptine	9-19	interleukin 1 beta	Mus musculus	136-144
12445834-0	2003	Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation.	tianeptine	42-52	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	91-94
12856820-2	2003	It was decided to evaluate the influence of imipramine (IMI), amitriptyline (AMI), fluvoxamine (FLU), mianserin (MIA) and tianeptine (TIA) on PLA2 activity after an acute and long-term (4 weeks) drug administration.	tianeptine	122-132	phospholipase A2 group IB	Rattus norvegicus	142-146
12435800-6	2002	The kinetics of the up-regulation of Mss4 gene expression measured by Northern blot during the imipramine, tianeptine, or fluoxetine treatments are consistent with an antidepressant effect that occurs after 3 weeks.	tianeptine	107-117	RAB interacting factor	Rattus norvegicus	37-41
12208559-4	2002	Tianeptine was shown to inhibit the ion currents induced by the inhibitory neurotransmitters GABA and glycine as well as the inwardly rectifying K(+) current induced by 5-HT and 8-hydroxy-2 (di-n-propylamino) tetraline hydrobromide (8-OH-DPAT), a 5-HT(1A) agonist.	tianeptine	0-10	5-hydroxytryptamine receptor 1A	Rattus norvegicus	247-254
12372016-0	2002	The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats.	tianeptine	19-29	carbonic anhydrase 3	Rattus norvegicus	100-103
12372016-2	2002	Here, the effects of long-term antidepressant application in rats with the drug tianeptine were examined at hippocampal CA3 commissural associational (c/a) glutamate receptor ion channels, employing the whole-cell patch-clamp technique.	tianeptine	80-90	carbonic anhydrase 3	Rattus norvegicus	120-123
12372016-10	2002	These results indicate that tianeptine targets the phosphorylation-state of glutamate receptors at the CA3 c/a synapse.	tianeptine	28-38	carbonic anhydrase 3	Rattus norvegicus	103-106
11939714-0	2002	Effect of tianeptine and fluoxetine on the levels of Met-enkephalin and mRNA encoding proenkephalin in the rat.	tianeptine	10-20	proenkephalin	Rattus norvegicus	86-99
12034133-7	2002	Tianeptine also normalized an impaired memory elicited by scopolamine (an antimuscarinic) or dizocilpine (non-competitive glutamatergic antagonist), while partially reversed that induced by TFMPP (5-HT(1B/1D/2A-2C/7) agonist/antagonist).	tianeptine	0-10	5-hydroxytryptamine receptor 1B	Homo sapiens	197-204
12034133-8	2002	Finally, tianeptine-fluoxetine coadministration had no effect on learning consolidation; nevertheless, administration of an acetylcholinesterase inhibitor, phenserine, potentiated subeffective tianeptine or fluoxetine doses.	tianeptine	193-203	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-144
8930312-6	1996	It is to be concluded that tianeptine, sertraline and clomipramine can regulate the 5-HT fraction present in the synaptic cleft, not only by acting at the level of the serotoninergic neurons, but also by favoring or reducing the access of the amine to monoamine oxidase type A which is synthesized within non-serotoninergic neurons and glial cells.	tianeptine	27-37	monoamine oxidase A	Rattus norvegicus	252-276
8986335-5	1996	These data are consistent with the previously demonstrated ability of tianeptine to prevent chronic stress-induced atrophy of the CA3 dendrites.	tianeptine	70-80	carbonic anhydrase 3	Rattus norvegicus	130-133
9729259-0	1998	Effect of chronic restraint stress and tianeptine on growth factors, growth-associated protein-43 and microtubule-associated protein 2 mRNA expression in the rat hippocampus.	tianeptine	39-49	microtubule-associated protein 2	Rattus norvegicus	102-134
9729259-3	1998	In order to investigate the underlying mechanism of these phenomena, we evaluated the effect of chronic restraint and tianeptine on mRNA expression of neurotrophic factors such as brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and basic fibroblast growth factor (bFGF).	tianeptine	118-128	brain-derived neurotrophic factor	Rattus norvegicus	180-213
9405958-7	1997	Tianeptine treatment (10 mg/kg/day) prevented the stress-induced atrophy of dendrites of CA3 pycamidal neurons, whereas neither fluoxetine (10 mg/kg/day) nor desipramine (10 mg/kg/day) had any effect.	tianeptine	0-10	carbonic anhydrase 3	Homo sapiens	89-92
7531300-6	1994	The hypothermic response to the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 0.15 mg/kg, s.c.) was significantly attenuated after chronic setraline treatment, whereas tianeptine was inactive at the 2 doses tested.	tianeptine	198-208	5-hydroxytryptamine receptor 1A	Rattus norvegicus	32-38
7770093-0	1995	Effect of acute and prolonged tianeptine administration on the 5-HT transporter: electrophysiological, biochemical and radioligand binding studies in the rat brain.	tianeptine	30-40	solute carrier family 6 member 4	Rattus norvegicus	63-79
7770093-2	1995	Microiontophoretic application of tianeptine onto dorsal hippocampus CA3 pyramidal neurons, as well as its intravenous administration (2 mg/kg), increased their firing frequency.	tianeptine	34-44	carbonic anhydrase 3	Rattus norvegicus	69-72
7770094-4	1995	The responsiveness of CA3 pyramidal neurons to microiontophoretic application of 5-HT remained unchanged after sustained tianeptine administration, but it was markedly enhanced in rats treated with repeated electroconvulsive shocks.	tianeptine	121-131	carbonic anhydrase 3	Rattus norvegicus	22-25
7925606-0	1994	Tianeptine decreases both serotonin transporter mRNA and binding sites in rat brain.	tianeptine	0-10	solute carrier family 6 member 4	Rattus norvegicus	26-47
7925606-2	1994	Tianeptine (10 mg/kg twice daily, for 14 days) significantly reduced both the expression of serotonin transporter mRNA and serotonin transporter binding sites labeled by [3H]paroxetine in rat dorsal raphe nucleus.	tianeptine	0-10	solute carrier family 6 member 4	Rattus norvegicus	92-113
7925606-2	1994	Tianeptine (10 mg/kg twice daily, for 14 days) significantly reduced both the expression of serotonin transporter mRNA and serotonin transporter binding sites labeled by [3H]paroxetine in rat dorsal raphe nucleus.	tianeptine	0-10	solute carrier family 6 member 4	Rattus norvegicus	123-144
1836611-9	1991	Finally, tianeptine tends to increase dendrite ramifications of the hippocampus" pyramidal neurons (CA3) in isolated rats, thus counteracting the effect of isolation stress.	tianeptine	9-19	carbonic anhydrase 3	Rattus norvegicus	100-103
7912195-3	1994	We have investigated the site of action of tianeptine, a 5-HT uptake enhancer, in sheep since it is possible to collect hypophysial portal blood for the simultaneous determination of growth hormone-releasing hormone (GHRH) and somatostatin in this species under conscious, unstressed conditions.	tianeptine	43-53	LOC780526	Ovis aries	183-215
7912195-8	1994	Tianeptine acts centrally to stimulate GH secretion in the sheep and its effect is mediated through changes in GHRH but not somatostatin release into hypophysial portal blood.	tianeptine	0-10	somatotropin	Ovis aries	39-41
7912195-8	1994	Tianeptine acts centrally to stimulate GH secretion in the sheep and its effect is mediated through changes in GHRH but not somatostatin release into hypophysial portal blood.	tianeptine	0-10	LOC780526	Ovis aries	111-115
8149980-3	1994	In contrast, chronic administration of tianeptine (10 mg/kg twice a day for 15 days) induced a significant decrease in the concentration of corticotropin-releasing factor (CRF) in the hypothalamus and adrenocorticotropin (ACTH) in the anterior lobe of the pituitary.	tianeptine	39-49	corticotropin releasing hormone	Rattus norvegicus	140-170
8364729-4	1993	[3H]paroxetine-binding to serotonin transporter sites was decreased by tianeptine treatment as well as by imipramine in both hippocampus and cerebral cortex, with some overlap of the fields that were significantly affected, whereas there were no effects of stress per se and no evidence of a stress x drug interaction.	tianeptine	71-81	solute carrier family 6 member 4	Rattus norvegicus	26-47
8364729-6	1993	Whereas the actions of imipramine and tianeptine on 5-HT2 and 5-HT1A receptors are specific to each drug, the surprising finding of a similar effect of both drugs to reduce serotonin transporter sites labelled by [3H]paroxetine suggest the possibility of a common action for these two drugs in spite of their opposite effects on serotonin re-uptake.	tianeptine	38-48	5-hydroxytryptamine receptor 1A	Rattus norvegicus	62-68
1558901-2	1992	Taking into account the antidepressant effect of tianeptine in animals and humans, we have measured the influence of a pretreatment with tianeptine (10 mg/kg IP 1 hr beforehand) on some consequences of a single 2-hr restraint stress session in male rats.	tianeptine	137-147	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	158-162
1389023-3	1992	In vivo, tianeptine potentiates the depletion of rat brain 5-HT by 4-methyl-alpha-ethyl metatyramine and increases rat hippocampal 5-HIAA; 5-HT uptake inhibitors (e.g. fluoxetine) have opposite effects.	tianeptine	9-19	POU class 6 homeobox 1	Rattus norvegicus	53-60
1389023-4	1992	On iontophoretic injection into CA1 pyramidal cells, tianeptine shortens the period of neuronal hypoactivity caused by GABA or 5-HT, whereas other tricyclics prolong it, and it enhances attention, learning, and memory in laboratory animals, while classical tricyclics have opposite effects.	tianeptine	53-63	carbonic anhydrase 1	Rattus norvegicus	32-35
1389024-2	1992	In a multicentre trial in which 380 depressed patients were treated for one year, tianeptine produced a significant reduction in the MADRS scores from day 14, with a sustained reduction maintained for up to 12 months; other measures of efficacy (HRSA, HSCL, and CGI) also reflected the improvement.	tianeptine	82-92	selenocysteine lyase	Homo sapiens	252-256
8223931-0	1993	Antagonism by citalopram and tianeptine of presynaptic 5-HT1B heteroreceptors inhibiting acetylcholine release.	tianeptine	29-39	5-hydroxytryptamine receptor 1B	Rattus norvegicus	55-61
7871006-4	1993	Other drugs that reduce 5-HT function (tianeptine which increases 5-HT uptake; buspirone, a 5-HT1A receptor agonist/partial agonist; zacopride, a 5-HT3 receptor antagonist) also reversed this anxiogenic response.	tianeptine	39-49	5-hydroxytryptamine receptor 3A	Rattus norvegicus	146-160
35211768-1	2022	RATIONALE: Tianeptine is a mu-opioid receptor (MOR) agonist with increasing reports of abuse in human populations.	tianeptine	11-21	opioid receptor mu 1	Homo sapiens	27-45
1660816-4	1991	injection of tianeptine (10 mg/kg), 120 min before stress caused a significant decrease of ACTH and corticosterone levels.	tianeptine	13-23	proopiomelanocortin	Homo sapiens	91-95
1660816-6	1991	The inhibitory effect of tianeptine on stress-induced elevations of plasma ACTH and corticosterone occurred from 1 to 3 h after the injection.	tianeptine	25-35	proopiomelanocortin	Homo sapiens	75-79
1660816-7	1991	Administration of increasing doses of tianeptine revealed that only the highest doses (10 and 20 mg/kg) had a significant effect on stress-evoked stimulation of ACTH and corticosterone secretion.	tianeptine	38-48	proopiomelanocortin	Homo sapiens	161-165
34464676-8	2021	The levels of Arc and Homer1a, but not c-Fos, BdnfIV and Zif268, were increased by tianeptine.	tianeptine	83-93	activity regulated cytoskeleton associated protein	Homo sapiens	14-17
34464676-8	2021	The levels of Arc and Homer1a, but not c-Fos, BdnfIV and Zif268, were increased by tianeptine.	tianeptine	83-93	homer scaffold protein 1	Homo sapiens	22-29
35211768-1	2022	RATIONALE: Tianeptine is a mu-opioid receptor (MOR) agonist with increasing reports of abuse in human populations.	tianeptine	11-21	opioid receptor mu 1	Homo sapiens	47-50
35211768-11	2022	CONCLUSIONS: Tianeptine presents as a MOR agonist with resistance to tolerance and dependence in our ICSS assay in rats, and it has lower abuse potential by this metric than many commonly abused opioids.	tianeptine	13-23	opioid receptor mu 1	Homo sapiens	38-41
35211768-12	2022	Nonetheless, tianeptine produces MOR agonist-like acute adverse effects that include motor impairment, constipation, and respiratory depression.	tianeptine	13-23	opioid receptor mu 1	Homo sapiens	33-36
2700774-12	1989	The action of tianeptine on anxious-depressive symptomatology was confirmed by the concomitant improvement of global clinical rating and patients" self-rating (HSCL).	tianeptine	14-24	selenocysteine lyase	Homo sapiens	160-164
2818623-8	1989	We conclude that tianeptine is activated by hamster, mouse and rat liver cytochrome P-450 into a reactive metabolite.	tianeptine	17-27	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	73-89
31785246-9	2020	In summary, the outcomes of the present study showed that activation and inhibition of CB1 receptors as well as inhibition of CB2 receptors may increase the antidepressant activity of tianeptine, whereas only inhibition of CB1 and CB2 receptors has a potential to augment the antidepressant activity of agomelatine.	tianeptine	184-194	cannabinoid receptor 1 (brain)	Mus musculus	87-90
33154348-0	2020	Corticotropin releasing hormone receptor CRHR1 gene is associated with tianeptine antidepressant response in a large sample of outpatients from real-life settings.	tianeptine	71-81	corticotropin releasing hormone receptor 1	Homo sapiens	41-46
33154348-7	2020	These findings suggest direct pharmacological consequences of CRHR1 polymorphisms in the antidepressant tianeptine response and remission, in MDE patients.	tianeptine	104-114	corticotropin releasing hormone receptor 1	Homo sapiens	62-67
32734307-7	2020	Bromadol, brorphine, isotonitazene, piperidylthiambutene, and tianeptine had the highest efficacy (Emax) values, exceeding that of the reference compound hydromorphone >= 1.3-fold (betaarr2 assay) and > 2.6-fold (mini-Gi assay).	tianeptine	62-72	arrestin beta 2	Homo sapiens	181-189
3180117-2	1988	The interaction of tianeptine and clomipramine with the response of CA1 cells to iontophoretically applied 5-HT or GABA was also investigated.	tianeptine	19-29	carbonic anhydrase 1	Rattus norvegicus	68-71
3180117-4	1988	perfusion of tianeptine decreased the firing rate of locus coeruleus neurons (ID50 = 1.74 +/- 0.2 mg/kg), did not modify the firing rate of raphe dorsalis neurons, and increased the firing rate of CA1 pyramidal cells (ED50 = 0.68 +/- 0.17 mg/kg).	tianeptine	13-23	carbonic anhydrase 1	Rattus norvegicus	197-200
31785246-9	2020	In summary, the outcomes of the present study showed that activation and inhibition of CB1 receptors as well as inhibition of CB2 receptors may increase the antidepressant activity of tianeptine, whereas only inhibition of CB1 and CB2 receptors has a potential to augment the antidepressant activity of agomelatine.	tianeptine	184-194	cannabinoid receptor 2 (macrophage)	Mus musculus	126-129
31785246-9	2020	In summary, the outcomes of the present study showed that activation and inhibition of CB1 receptors as well as inhibition of CB2 receptors may increase the antidepressant activity of tianeptine, whereas only inhibition of CB1 and CB2 receptors has a potential to augment the antidepressant activity of agomelatine.	tianeptine	184-194	cannabinoid receptor 1 (brain)	Mus musculus	223-226
31785246-9	2020	In summary, the outcomes of the present study showed that activation and inhibition of CB1 receptors as well as inhibition of CB2 receptors may increase the antidepressant activity of tianeptine, whereas only inhibition of CB1 and CB2 receptors has a potential to augment the antidepressant activity of agomelatine.	tianeptine	184-194	cannabinoid receptor 2 (macrophage)	Mus musculus	231-234
31889042-6	2019	TIA administration increased the levels of all enzymes in the prefrontal cortex as well as elevated DAGLalpha expression in the frontal cortex and dorsal striatum.	tianeptine	0-3	diacylglycerol lipase, alpha	Rattus norvegicus	100-109
30610610-7	2019	Moreover, tianeptine administration diminished the increase in CCR2 levels in both brain areas, while in the hippocampus, tianeptine, along with venlafaxine CCL2 and iNOS levels.	tianeptine	10-20	C-C motif chemokine receptor 2	Rattus norvegicus	63-67
31200233-0	2019	Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist.	tianeptine	16-26	adenosine A2a receptor	Mus musculus	117-139
30610610-8	2019	Next, we observed that in the hippocampus, tianeptine and fluoxetine suppressed upregulation of TLR4.	tianeptine	43-53	toll-like receptor 4	Rattus norvegicus	96-100
30610610-10	2019	Importantly, in the hippocampus, all antidepressants normalized evoked by stress changes in caspase-1 level, while tianeptine and venlafaxine also affect the levels of ASC and NLRP3 subunits.	tianeptine	115-125	PYD and CARD domain containing	Rattus norvegicus	168-171
30610610-10	2019	Importantly, in the hippocampus, all antidepressants normalized evoked by stress changes in caspase-1 level, while tianeptine and venlafaxine also affect the levels of ASC and NLRP3 subunits.	tianeptine	115-125	NLR family, pyrin domain containing 3	Rattus norvegicus	176-181
30485752-0	2019	Maternal separation induces long-term changes in mineralocorticoid receptor in rats subjected to chronic stress and treated with tianeptine.	tianeptine	129-139	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	49-75
30485752-7	2019	Tianeptine raised MR-ir in the CA3.	tianeptine	0-10	carbonic anhydrase 3	Rattus norvegicus	31-34
30367961-0	2019	Tianeptine antagonizes the reduction of PV+ and GAD67 cells number in dorsal hippocampus of socially isolated rats.	tianeptine	0-10	glutamate decarboxylase 1	Rattus norvegicus	48-53
29618004-0	2018	The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.	tianeptine	19-29	cyclin dependent kinase like 5	Homo sapiens	93-98
29932631-2	2018	Here we report on the synthesis and functional characterization of new HDAC inhibitors based structurally on tianeptine, a drug used primarily to treat major depressive disorder (MDD) that has a poorly understood mechanism of action.	tianeptine	109-119	histone deacetylase 9	Homo sapiens	71-75
29932631-3	2018	Since the chemical structure of tianeptine resembles certain HDAC inhibitors, we profiled the in vitro HDAC inhibitory activity of tianeptine and demonstrated its ability to inhibit the lysine deacetylase activity of a subset of class I HDACs.	tianeptine	131-141	histone deacetylase 9	Homo sapiens	103-107
29932631-4	2018	Consistent with a model of active site Zn2+ chelation by the carboxylic acid present in tianeptine, newly synthesized analogues containing either a hydroxamic acid or ortho-aminoanilide exhibited increased potency and selectivity among the HDAC family.	tianeptine	88-98	histone deacetylase 9	Homo sapiens	240-244
29932631-6	2018	Most notably, tianeptinaline, a class I HDAC-selective analogue of tianeptine, but not tianeptine itself, increased histone acetylation, and enhanced CREB-mediated transcription and the expression of Arc (activity-regulated cytoskeleton-associated protein).	tianeptine	67-77	histone deacetylase 9	Homo sapiens	40-44
29976873-0	2018	Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures.	tianeptine	54-64	NLR family pyrin domain containing 3	Homo sapiens	14-19
29976873-6	2018	Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species.	tianeptine	0-10	CD40 molecule	Homo sapiens	106-110
29976873-6	2018	Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species.	tianeptine	0-10	interleukin 18	Homo sapiens	253-258
29976873-6	2018	Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species.	tianeptine	0-10	interleukin 6	Homo sapiens	260-264
29976873-6	2018	Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species.	tianeptine	0-10	tumor necrosis factor	Homo sapiens	266-293
29976873-6	2018	Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species.	tianeptine	0-10	tumor necrosis factor	Homo sapiens	295-304
29976873-6	2018	Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species.	tianeptine	0-10	C-C motif chemokine ligand 2	Homo sapiens	311-338
29976873-6	2018	Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species.	tianeptine	0-10	C-C motif chemokine ligand 2	Homo sapiens	340-344
30323233-5	2018	The disturbed AMPAR surface diffusion is rescued by the antidepressant drug tianeptine via the BDNF signaling pathway.	tianeptine	76-86	brain derived neurotrophic factor	Mus musculus	95-99
29618004-7	2018	Importantly, we find that tianeptine, a cognitive enhancer and antidepressant drug, known to recruit and stabilise AMPA-Rs at the synaptic sites, can normalise the expression of membrane inserted AMPA-Rs as well as the number of PSD-95 clusters, suggesting its therapeutic potential for patients with mutations in CDKL5.	tianeptine	26-36	discs large MAGUK scaffold protein 4	Homo sapiens	229-235
29618004-7	2018	Importantly, we find that tianeptine, a cognitive enhancer and antidepressant drug, known to recruit and stabilise AMPA-Rs at the synaptic sites, can normalise the expression of membrane inserted AMPA-Rs as well as the number of PSD-95 clusters, suggesting its therapeutic potential for patients with mutations in CDKL5.	tianeptine	26-36	cyclin dependent kinase like 5	Homo sapiens	314-319
29163165-12	2017	All drugs in hippocampus, while tianeptine and venlafaxine in frontal cortex normalized the CXCL12 level in prenatally stressed offspring.	tianeptine	32-42	C-X-C motif chemokine ligand 12	Rattus norvegicus	92-98
29163165-13	2017	Moreover, in hippocampus only fluoxetine enhanced CXCR4 level, while fluoxetine and tianeptine diminished CXCR7 level in frontal cortex.	tianeptine	84-94	atypical chemokine receptor 3	Rattus norvegicus	106-111
29163165-14	2017	Additionally, the diminished by prenatal stress levels of CX3CL1 and CX3CR1 in the both examined brain areas were normalized by chronic tianeptine and partially fluoxetine administration.	tianeptine	136-146	C-X3-C motif chemokine ligand 1	Rattus norvegicus	58-64
29163165-14	2017	Additionally, the diminished by prenatal stress levels of CX3CL1 and CX3CR1 in the both examined brain areas were normalized by chronic tianeptine and partially fluoxetine administration.	tianeptine	136-146	C-X3-C motif chemokine receptor 1	Rattus norvegicus	69-75
28706449-0	2017	Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model.	tianeptine	11-21	brain derived neurotrophic factor	Mus musculus	54-58
28303899-4	2017	We recently reported that tianeptine is a full agonist at the mu opioid receptor (MOR).	tianeptine	26-36	opioid receptor mu 1	Homo sapiens	62-80
28303899-4	2017	We recently reported that tianeptine is a full agonist at the mu opioid receptor (MOR).	tianeptine	26-36	opioid receptor mu 1	Homo sapiens	82-85
28303899-5	2017	Here we demonstrate that the acute and chronic antidepressant-like behavioral effects of tianeptine in mice require MOR.	tianeptine	89-99	opioid receptor, mu 1	Mus musculus	116-119
28303899-7	2017	Furthermore, the primary metabolite of tianeptine (MC5), which has a longer half-life, mimics the behavioral effects of tianeptine in a MOR-dependent fashion.	tianeptine	39-49	opioid receptor mu 1	Homo sapiens	136-139
28303899-7	2017	Furthermore, the primary metabolite of tianeptine (MC5), which has a longer half-life, mimics the behavioral effects of tianeptine in a MOR-dependent fashion.	tianeptine	120-130	opioid receptor mu 1	Homo sapiens	136-139
28706449-7	2017	To assess the relationship between tianeptine and expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated cAMP response element-binding protein (p-CREB), western blotting and immunohistochemistry analyses were performed.	tianeptine	35-45	brain derived neurotrophic factor	Mus musculus	71-104
28223757-0	2017	Attenuation of Dickkopf 1-Induced Hair Growth Inhibition in Cultured Human Hair Follicles by Tianeptine.	tianeptine	93-103	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	15-25
28535568-16	2017	The increase in DRG ATF3 in neuropathic mice was reduced by tianeptine (P < 0.05).	tianeptine	60-70	activating transcription factor 3	Mus musculus	20-24
31994095-0	2017	The effects of desipramine, fluoxetine, or tianeptine on changes in bulbar BDNF levels induced by chronic social instability stress and inflammation.	tianeptine	43-53	brain-derived neurotrophic factor	Rattus norvegicus	75-79
31994095-9	2017	Chronic administration of desipramine, fluoxetine, or tianeptine increased the BDNF mRNA expression and protein levels in the LPS-injected stressed rats.	tianeptine	54-64	brain-derived neurotrophic factor	Rattus norvegicus	79-83
28359918-0	2017	The effects of desipramine, fluoxetine, or tianeptine on changes in bulbar BDNF levels induced by chronic social instability stress and inflammation.	tianeptine	43-53	brain-derived neurotrophic factor	Rattus norvegicus	75-79
28359918-9	2017	Chronic administration of desipramine, fluoxetine, or tianeptine increased the BDNF mRNA expression and protein levels in the LPS-injected stressed rats.	tianeptine	54-64	brain-derived neurotrophic factor	Rattus norvegicus	79-83
27392529-0	2016	Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.	tianeptine	24-34	S100 calcium binding protein B	Homo sapiens	91-96
28352358-5	2017	Then, the effect of 28-day daily treatment with desipramine (DMI; 10 mg/kg), fluoxetine (5 mg/kg) or tianeptine (10 mg/kg) on the number of copies of VEGF mRNA in the amygdala, hippocampus and hypothalamus, and on serum VEGF protein levels, of rats subjected to chronic stress was determined.	tianeptine	101-111	vascular endothelial growth factor A	Rattus norvegicus	150-154
27604299-7	2016	MS-chronic stress/tianeptine rats showed a diminished CA1 area than the corresponding MS-unstressed/tianeptine rats.	tianeptine	18-28	carbonic anhydrase 1	Rattus norvegicus	54-57
27604299-11	2016	Our results show that tianeptine can affect the CA1 area volume differently depending on the nature and quantity of stressors but cannot alter freezing to context.	tianeptine	22-32	carbonic anhydrase 1	Rattus norvegicus	48-51
27392529-3	2016	AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS).	tianeptine	159-169	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
26640965-7	2016	Analyses of signaling pathways demonstrate that tianeptine led to the suppression of LPS-induced TLR4 expression and ERK1/2 phosphorylation.	tianeptine	48-58	toll like receptor 4	Homo sapiens	97-101
27129862-0	2016	Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions.	tianeptine	0-10	CREB regulated transcription coactivator 1	Mus musculus	19-25
27129862-3	2016	OBJECTIVE: The aim of the present study was to determine whether alterations in mTORC1 signaling are observable following treatment with tianeptine under toxic conditions induced by B27 deprivation.	tianeptine	137-147	CREB regulated transcription coactivator 1	Mus musculus	80-86
27129862-7	2016	RESULTS: Tianeptine significantly increased the phosphorylation of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK.	tianeptine	9-19	CREB regulated transcription coactivator 1	Mus musculus	67-73
27129862-7	2016	RESULTS: Tianeptine significantly increased the phosphorylation of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK.	tianeptine	9-19	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	75-82
27129862-7	2016	RESULTS: Tianeptine significantly increased the phosphorylation of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK.	tianeptine	9-19	ribosomal protein S6 kinase B1	Rattus norvegicus	84-90
27129862-7	2016	RESULTS: Tianeptine significantly increased the phosphorylation of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK.	tianeptine	9-19	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
27129862-7	2016	RESULTS: Tianeptine significantly increased the phosphorylation of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK.	tianeptine	9-19	Eph receptor B1	Rattus norvegicus	101-104
27129862-9	2016	Tianeptine increased BDNF, dendritic outgrowth, spine density, and synaptic proteins; all of these effects were blocked by the mTORC1 inhibitor.	tianeptine	0-10	brain-derived neurotrophic factor	Rattus norvegicus	21-25
27129862-9	2016	Tianeptine increased BDNF, dendritic outgrowth, spine density, and synaptic proteins; all of these effects were blocked by the mTORC1 inhibitor.	tianeptine	0-10	CREB regulated transcription coactivator 1	Mus musculus	127-133
27129862-10	2016	CONCLUSIONS: In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases dendritic outgrowth, spine density, and synaptic proteins through mTORC1 signaling under toxic conditions in rat primary hippocampal neurons.	tianeptine	49-59	CREB regulated transcription coactivator 1	Mus musculus	74-80
27129862-10	2016	CONCLUSIONS: In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases dendritic outgrowth, spine density, and synaptic proteins through mTORC1 signaling under toxic conditions in rat primary hippocampal neurons.	tianeptine	49-59	CREB regulated transcription coactivator 1	Mus musculus	179-185
26640965-7	2016	Analyses of signaling pathways demonstrate that tianeptine led to the suppression of LPS-induced TLR4 expression and ERK1/2 phosphorylation.	tianeptine	48-58	mitogen-activated protein kinase 3	Homo sapiens	117-123
26640965-12	2016	The beneficial tianeptine action is mediated through the inhibition of Toll-like receptor 4 (TLR4) expression as well as the TLR4-related pathways: extracellular signal-regulated kinase 1/2 (ERK1/2), caspase-3-dependent protein kinase delta (PKCdelta) cleavage and the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	tianeptine	15-25	toll like receptor 4	Homo sapiens	71-91
26640965-12	2016	The beneficial tianeptine action is mediated through the inhibition of Toll-like receptor 4 (TLR4) expression as well as the TLR4-related pathways: extracellular signal-regulated kinase 1/2 (ERK1/2), caspase-3-dependent protein kinase delta (PKCdelta) cleavage and the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	tianeptine	15-25	toll like receptor 4	Homo sapiens	93-97
26640965-12	2016	The beneficial tianeptine action is mediated through the inhibition of Toll-like receptor 4 (TLR4) expression as well as the TLR4-related pathways: extracellular signal-regulated kinase 1/2 (ERK1/2), caspase-3-dependent protein kinase delta (PKCdelta) cleavage and the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	tianeptine	15-25	toll like receptor 4	Homo sapiens	125-129
26640965-12	2016	The beneficial tianeptine action is mediated through the inhibition of Toll-like receptor 4 (TLR4) expression as well as the TLR4-related pathways: extracellular signal-regulated kinase 1/2 (ERK1/2), caspase-3-dependent protein kinase delta (PKCdelta) cleavage and the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	tianeptine	15-25	mitogen-activated protein kinase 1	Homo sapiens	148-189
26640965-12	2016	The beneficial tianeptine action is mediated through the inhibition of Toll-like receptor 4 (TLR4) expression as well as the TLR4-related pathways: extracellular signal-regulated kinase 1/2 (ERK1/2), caspase-3-dependent protein kinase delta (PKCdelta) cleavage and the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	tianeptine	15-25	mitogen-activated protein kinase 3	Homo sapiens	191-197
26640965-12	2016	The beneficial tianeptine action is mediated through the inhibition of Toll-like receptor 4 (TLR4) expression as well as the TLR4-related pathways: extracellular signal-regulated kinase 1/2 (ERK1/2), caspase-3-dependent protein kinase delta (PKCdelta) cleavage and the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).	tianeptine	15-25	protein kinase C delta	Homo sapiens	242-250
26730381-4	2015	In the present results, fluoxetine, tianeptine, and milnacipran reduced glycine-induced ion current in the hippocampal CA1 neurons in nystatin-perforated patch clamp method.	tianeptine	36-46	carbonic anhydrase 1	Rattus norvegicus	119-122
26640965-6	2016	Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase.	tianeptine	21-31	interleukin 1 beta	Homo sapiens	161-169
26640965-6	2016	Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase.	tianeptine	21-31	interleukin 18	Homo sapiens	171-176
26640965-6	2016	Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase.	tianeptine	21-31	interleukin 6	Homo sapiens	178-182
26640965-6	2016	Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase.	tianeptine	21-31	tumor necrosis factor	Homo sapiens	187-214
26640965-6	2016	Our study shows that tianeptine attenuated the LPS-evoked inflammatory activation of microglia by decreasing the expression of proinflammatory cytokines such as IL-1beta, IL-18, IL-6 and tumor necrosis factor alpha (TNF-alpha), the release of nitric oxide (NO) and reactive oxygen species (ROS) as well as the expression of inducible nitric oxide synthase.	tianeptine	21-31	tumor necrosis factor	Homo sapiens	216-225
26247621-12	2015	Tianeptine-induced increases in binge-like drinking only in adolescents suggest that differential CaMKIIalpha-dependent AMPAR activation may underlie age-related escalation of binge drinking.	tianeptine	0-10	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	120-125
25560759-5	2015	Acute tianeptine treatment selectively altered Fos expression within subdivisions of the central nucleus of the amygdala (CEA) in a bidirectional manner that varied in relation to ongoing activation within the capsular subdivision and its prefrontal and intra-amygdalar inputs.	tianeptine	6-16	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	47-50
25560759-5	2015	Acute tianeptine treatment selectively altered Fos expression within subdivisions of the central nucleus of the amygdala (CEA) in a bidirectional manner that varied in relation to ongoing activation within the capsular subdivision and its prefrontal and intra-amygdalar inputs.	tianeptine	6-16	carcinoembryonic antigen gene family 4	Rattus norvegicus	122-125
25560759-9	2015	Together these findings provide a new perspective for understanding the mechanism supporting tianeptine"s clinical efficacy, as well as its potential influence on CEA-based learning mechanisms.	tianeptine	93-103	carcinoembryonic antigen gene family 4	Rattus norvegicus	163-166
25982324-8	2015	Both GAD65 expression and the GABA concentration in the spinal cord were decreased in neuropathic rats but were increased by tianeptine.	tianeptine	125-135	glutamate decarboxylase 2	Rattus norvegicus	5-10
25982324-11	2015	5-HT7 receptor of the GABAergic interneurons together with GAD65 plays a role in the activity of tianeptine at the spinal cord level.	tianeptine	97-107	glutamate decarboxylase 2	Rattus norvegicus	59-64
25168152-0	2014	Tianeptine sodium salt suppresses TNF-alpha-induced expression of matrix metalloproteinase-9 in human carcinoma cells via suppression of the PI3K/Akt-mediated NF-kappaB pathway.	tianeptine	0-22	tumor necrosis factor	Homo sapiens	34-43
25168152-0	2014	Tianeptine sodium salt suppresses TNF-alpha-induced expression of matrix metalloproteinase-9 in human carcinoma cells via suppression of the PI3K/Akt-mediated NF-kappaB pathway.	tianeptine	0-22	matrix metallopeptidase 9	Homo sapiens	66-92
25168152-0	2014	Tianeptine sodium salt suppresses TNF-alpha-induced expression of matrix metalloproteinase-9 in human carcinoma cells via suppression of the PI3K/Akt-mediated NF-kappaB pathway.	tianeptine	0-22	AKT serine/threonine kinase 1	Homo sapiens	146-149
25026323-0	2014	The atypical antidepressant and neurorestorative agent tianeptine is a mu-opioid receptor agonist.	tianeptine	55-65	opioid receptor mu 1	Homo sapiens	71-89
25026323-5	2014	Herein, we report the characterization of tianeptine as a mu-opioid receptor (MOR) agonist.	tianeptine	42-52	opioid receptor mu 1	Homo sapiens	58-76
25026323-5	2014	Herein, we report the characterization of tianeptine as a mu-opioid receptor (MOR) agonist.	tianeptine	42-52	opioid receptor mu 1	Homo sapiens	78-81
25026323-6	2014	Using radioligand binding and cell-based functional assays, including bioluminescence resonance energy transfer-based assays for G-protein activation and cAMP accumulation, we identified tianeptine as an efficacious MOR agonist (K(i Human) of 383+-183 nM and EC(50 Human) of 194+-70 nM  and EC(50 Mouse) of 641+-120 nM for G-protein activation).	tianeptine	187-197	opioid receptor mu 1	Homo sapiens	216-219
25026323-7	2014	Tianeptine was also a full delta-opioid receptor (DOR) agonist, although with much lower potency (EC(50 Human) of 37.4+-11.2 muM and EC(50 Mouse) of 14.5+-6.6  muM for G-protein activation).	tianeptine	0-10	latexin	Homo sapiens	125-128
25026323-7	2014	Tianeptine was also a full delta-opioid receptor (DOR) agonist, although with much lower potency (EC(50 Human) of 37.4+-11.2 muM and EC(50 Mouse) of 14.5+-6.6  muM for G-protein activation).	tianeptine	0-10	latexin	Homo sapiens	160-163
24296153-5	2014	Escitalopram, fluoxetine, paroxetine, sertraline, imipramine, tranylcypromine, and tianeptine significantly prevented B27 deprivation-induced decreases in levels of PSD-95, BDNF, and SYP.	tianeptine	83-93	discs large MAGUK scaffold protein 4	Rattus norvegicus	165-171
25110505-5	2014	METHODS: NCAM protein expression was measured in human neuroblastoma SH-SY5Y cells that were cultivated in serum-free media and treated with 0, 10, or 20 microM tianeptine for 6, 24, or 72 hours.	tianeptine	161-171	neural cell adhesion molecule 1	Homo sapiens	9-13
25110505-7	2014	CREB and pCREB expression was identified after treatment with 20 microM tianeptine for 6, 24, and 72 hours by Western blot.	tianeptine	72-82	cAMP responsive element binding protein 1	Homo sapiens	0-4
25110505-10	2014	CONCLUSION: Our findings indicated that the tianeptine antidepressant effect may occur by induction of NCAM140 expression and CREB phosphorylation.	tianeptine	44-54	cAMP responsive element binding protein 1	Homo sapiens	126-130
24296153-5	2014	Escitalopram, fluoxetine, paroxetine, sertraline, imipramine, tranylcypromine, and tianeptine significantly prevented B27 deprivation-induced decreases in levels of PSD-95, BDNF, and SYP.	tianeptine	83-93	brain-derived neurotrophic factor	Rattus norvegicus	173-177
24296153-5	2014	Escitalopram, fluoxetine, paroxetine, sertraline, imipramine, tranylcypromine, and tianeptine significantly prevented B27 deprivation-induced decreases in levels of PSD-95, BDNF, and SYP.	tianeptine	83-93	synaptophysin	Rattus norvegicus	183-186
24296153-8	2014	Specific inhibitors of calcium/calmodulin kinase II (CaMKII), KN-93, protein kinase A (PKA), H-89, or phosphatidylinositol 3-kinase (PI3K), LY294002, significantly decreased the effects of antidepressant drugs on dendritic outgrowth, whereas this effect was observed only with tianeptine for the PI3K inhibitor.	tianeptine	277-287	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	102-131
22849838-6	2012	Tianeptine treatment increased glutathione peroxidase (GSH-Px) and catalase (CAT) activities in spontaneous and Ca2+-stimulated uteri.	tianeptine	0-10	catalase	Rattus norvegicus	67-75
24105645-0	2014	The predominant protective effect of tianeptine over other antidepressants in models of neuronal apoptosis: the effect blocked by inhibitors of MAPK/ERK1/2 and PI3-K/Akt pathways.	tianeptine	37-47	mitogen-activated protein kinase 3	Homo sapiens	144-148
24105645-0	2014	The predominant protective effect of tianeptine over other antidepressants in models of neuronal apoptosis: the effect blocked by inhibitors of MAPK/ERK1/2 and PI3-K/Akt pathways.	tianeptine	37-47	mitogen-activated protein kinase 3	Homo sapiens	149-155
24105645-0	2014	The predominant protective effect of tianeptine over other antidepressants in models of neuronal apoptosis: the effect blocked by inhibitors of MAPK/ERK1/2 and PI3-K/Akt pathways.	tianeptine	37-47	AKT serine/threonine kinase 1	Homo sapiens	166-169
23262120-8	2013	These stress-induced changes in glutamate efflux and vGLUT2 expression were inhibited by daily tianeptine administration.	tianeptine	95-105	solute carrier family 17 member 6	Rattus norvegicus	53-59
23262120-9	2013	Moreover, tianeptine administration increased the vesicular localization of SNAP-25, which could account for the ability of tianeptine to modify glutamatergic tone in non-stressed control rats.	tianeptine	10-20	synaptosome associated protein 25	Rattus norvegicus	76-83
23262120-9	2013	Moreover, tianeptine administration increased the vesicular localization of SNAP-25, which could account for the ability of tianeptine to modify glutamatergic tone in non-stressed control rats.	tianeptine	124-134	synaptosome associated protein 25	Rattus norvegicus	76-83
23069580-7	2012	Tianeptine, olanzapine and fluoxetine decreased the enhanced levels of plasma ACTH and IL-6.	tianeptine	0-10	pro-opiomelanocortin-alpha	Mus musculus	78-82
23069580-7	2012	Tianeptine, olanzapine and fluoxetine decreased the enhanced levels of plasma ACTH and IL-6.	tianeptine	0-10	interleukin 6	Mus musculus	87-91
22659397-0	2012	Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.	tianeptine	0-10	brain-derived neurotrophic factor	Rattus norvegicus	68-72
22659397-4	2012	The BDNF levels were increased in the prefrontal cortex with tianeptine and decreased in the nucleus accumbens after acute treatment; in chronic treatment, BDNF levels were increased in the prefrontal and hippocampus with tianeptine.	tianeptine	61-71	brain-derived neurotrophic factor	Rattus norvegicus	4-8
22659397-4	2012	The BDNF levels were increased in the prefrontal cortex with tianeptine and decreased in the nucleus accumbens after acute treatment; in chronic treatment, BDNF levels were increased in the prefrontal and hippocampus with tianeptine.	tianeptine	222-232	brain-derived neurotrophic factor	Rattus norvegicus	4-8
22659397-4	2012	The BDNF levels were increased in the prefrontal cortex with tianeptine and decreased in the nucleus accumbens after acute treatment; in chronic treatment, BDNF levels were increased in the prefrontal and hippocampus with tianeptine.	tianeptine	222-232	brain-derived neurotrophic factor	Rattus norvegicus	156-160
22659397-5	2012	Acute treatment decreased the citrate synthase activity in the prefrontal cortex with tianeptine, and increased it in the amygdala with imipramine; chronic treatment increased the citrate synthase in the hippocampus with tianeptine.	tianeptine	86-96	citrate synthase	Rattus norvegicus	30-46
22659397-5	2012	Acute treatment decreased the citrate synthase activity in the prefrontal cortex with tianeptine, and increased it in the amygdala with imipramine; chronic treatment increased the citrate synthase in the hippocampus with tianeptine.	tianeptine	221-231	citrate synthase	Rattus norvegicus	180-196
22659397-11	2012	In conclusion, tianeptine exerted antidepressant-like behavior which can be attributed to its effects on pathways related to depression, such as BDNF and metabolism energy.	tianeptine	15-25	brain-derived neurotrophic factor	Rattus norvegicus	145-149
23933152-7	2013	Importantly, tianeptine treatment decreased high K(+)-stimulated secretion of norepinephrine and chromogranin A in PC12 cells and of epinephrine in the mouse pheochromocytoma MPC cells.	tianeptine	13-23	chromogranin A	Rattus norvegicus	97-111
22733125-4	2013	Strikingly, tianeptine rapidly reduces the surface diffusion of AMPA receptor (AMPAR) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent mechanism that enhances the binding of AMPAR auxiliary subunit stargazin with PSD-95.	tianeptine	12-22	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	96-141
22733125-4	2013	Strikingly, tianeptine rapidly reduces the surface diffusion of AMPA receptor (AMPAR) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent mechanism that enhances the binding of AMPAR auxiliary subunit stargazin with PSD-95.	tianeptine	12-22	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	143-149
22733125-4	2013	Strikingly, tianeptine rapidly reduces the surface diffusion of AMPA receptor (AMPAR) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent mechanism that enhances the binding of AMPAR auxiliary subunit stargazin with PSD-95.	tianeptine	12-22	calcium channel, voltage-dependent, gamma subunit 2	Mus musculus	224-233
22733125-4	2013	Strikingly, tianeptine rapidly reduces the surface diffusion of AMPA receptor (AMPAR) through a Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent mechanism that enhances the binding of AMPAR auxiliary subunit stargazin with PSD-95.	tianeptine	12-22	discs large MAGUK scaffold protein 4	Mus musculus	239-245
22828748-5	2012	We tested this prediction by examining the impact of tianeptine, an antidepressant with proven clinical efficacy, on neurons of the lateral amygdala (LA) and hippocampal area CA1.	tianeptine	53-63	carbonic anhydrase 1	Homo sapiens	175-178
22828748-7	2012	By contrast, tianeptine enhances both NMDA and AMPA currents in area CA1.	tianeptine	13-23	carbonic anhydrase 1	Homo sapiens	69-72
22849838-6	2012	Tianeptine treatment increased glutathione peroxidase (GSH-Px) and catalase (CAT) activities in spontaneous and Ca2+-stimulated uteri.	tianeptine	0-10	catalase	Rattus norvegicus	77-80
22849838-7	2012	A significant decrease in glutathione-reductase (GR) activity in both spontaneous and Ca2+-induced uterine contractions after tianeptine treatment indicated a reduction in reduced glutathione and consequently a shift toward a more oxidised state in the treated uteri.	tianeptine	126-136	glutathione-disulfide reductase	Rattus norvegicus	26-47
22849838-7	2012	A significant decrease in glutathione-reductase (GR) activity in both spontaneous and Ca2+-induced uterine contractions after tianeptine treatment indicated a reduction in reduced glutathione and consequently a shift toward a more oxidised state in the treated uteri.	tianeptine	126-136	glutathione-disulfide reductase	Rattus norvegicus	49-51
22849838-8	2012	In spontaneously contracting uteri, tianeptine caused a decrease in copper-zinc SOD (CuZnSOD) activity.	tianeptine	36-46	superoxide dismutase 1	Rattus norvegicus	85-92
21200377-7	2010	MAO-A was inhibited by the following drugs: pargyline > clorgyline > iproniazid > fluoxetine > desipramine > amitriptyline > imipramine > citalopram > venlafaxine > reboxetine > olanzapine > mirtazapine > tianeptine > moclobemide, cocaine >> lithium, valproate.	tianeptine	241-251	monoamine oxidase A	Sus scrofa	0-5
22348811-7	2012	Administration of 5-HT(3) receptor antagonist ondansetron (0.5, 1 and 2 mg/kg), but not 5-HT(2) receptor antagonist ketanserine (0.5, 1 and 2 mg/kg), reduced the antinociceptive effect of tianeptine (10mg/kg).	tianeptine	188-198	5-hydroxytryptamine receptor 3A	Rattus norvegicus	18-34
22056552-0	2011	Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.	tianeptine	0-10	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	52-58
22056552-0	2011	Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.	tianeptine	0-10	mitogen-activated protein kinase 14	Mus musculus	75-78
22056552-0	2011	Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.	tianeptine	0-10	cyclin-dependent kinase 20	Mus musculus	80-83
22056552-0	2011	Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.	tianeptine	0-10	mitogen-activated protein kinase 1	Mus musculus	87-91
22056552-0	2011	Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.	tianeptine	0-10	mitogen-activated protein kinase 8	Mus musculus	96-99
22056552-6	2011	Tianeptine, 10 muM, enhanced the GluA1-dependent initial phase of LTP, whereas 100 muM impaired the latter phases, indicating a critical role of GluA1 subunit phosphorylation in the excitation.	tianeptine	0-10	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	33-38
22056552-6	2011	Tianeptine, 10 muM, enhanced the GluA1-dependent initial phase of LTP, whereas 100 muM impaired the latter phases, indicating a critical role of GluA1 subunit phosphorylation in the excitation.	tianeptine	0-10	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	145-150
22056552-7	2011	Tianeptine rapidly increased the phosphorylation level of Ser(831)-GluA1 and Ser(845)-GluA1.	tianeptine	0-10	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	67-72
22056552-7	2011	Tianeptine rapidly increased the phosphorylation level of Ser(831)-GluA1 and Ser(845)-GluA1.	tianeptine	0-10	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	86-91
22056552-8	2011	Using H-89 and KN-93, we show that the activation of both PKA and CaMKII is critical in the effect of Tianeptine on AMPA responses.	tianeptine	102-112	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	66-72
22056552-9	2011	Moreover, the phosphorylation states of Ser(217/221)-MEK and Thr(183)/Tyr(185)-p42MAPK were increased by Tianeptine and specific kinase blockers of the MAPK pathways (PD 98095, SB 203580 and SP600125) prevented the effects of Tianeptine.	tianeptine	105-115	mitogen-activated protein kinase 1	Mus musculus	79-86
22056552-9	2011	Moreover, the phosphorylation states of Ser(217/221)-MEK and Thr(183)/Tyr(185)-p42MAPK were increased by Tianeptine and specific kinase blockers of the MAPK pathways (PD 98095, SB 203580 and SP600125) prevented the effects of Tianeptine.	tianeptine	105-115	mitogen-activated protein kinase 1	Mus musculus	82-86
22056552-9	2011	Moreover, the phosphorylation states of Ser(217/221)-MEK and Thr(183)/Tyr(185)-p42MAPK were increased by Tianeptine and specific kinase blockers of the MAPK pathways (PD 98095, SB 203580 and SP600125) prevented the effects of Tianeptine.	tianeptine	226-236	mitogen-activated protein kinase 1	Mus musculus	79-86
22056552-9	2011	Moreover, the phosphorylation states of Ser(217/221)-MEK and Thr(183)/Tyr(185)-p42MAPK were increased by Tianeptine and specific kinase blockers of the MAPK pathways (PD 98095, SB 203580 and SP600125) prevented the effects of Tianeptine.	tianeptine	226-236	mitogen-activated protein kinase 1	Mus musculus	82-86
21271304-8	2011	A discussion is made of recent findings that the atypical antidepressant tianeptine increases CRMP2 expression, whereas other, neuroactive small molecules including the epilepsy drug lacosamide and the natural brain metabolite lanthionine ketimine appear to bind CRMP2 directly with concomitant affects on neural structure.	tianeptine	73-83	dihydropyrimidinase like 2	Homo sapiens	94-99
21271304-8	2011	A discussion is made of recent findings that the atypical antidepressant tianeptine increases CRMP2 expression, whereas other, neuroactive small molecules including the epilepsy drug lacosamide and the natural brain metabolite lanthionine ketimine appear to bind CRMP2 directly with concomitant affects on neural structure.	tianeptine	73-83	dihydropyrimidinase like 2	Homo sapiens	263-268
22567428-8	2012	The antidepressant Tianeptine was used for inducing p-GluA1, which resulted in enhanced AMPA-evoked spiking.	tianeptine	19-29	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	54-59
21175585-0	2011	The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells: role of GS and NOS, and NF-kappaB suppression.	tianeptine	25-35	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	39-44
21175585-6	2011	In this study, we determined whether tianeptine protects astroglial cells from the neurodegenerative effects of gp120.	tianeptine	37-47	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	112-117
21175585-10	2011	KEY RESULTS: Tianeptine showed an anti-apoptotic effect and prevented caspase-3 activation by gp120.	tianeptine	13-23	caspase 3	Homo sapiens	70-79
21175585-10	2011	KEY RESULTS: Tianeptine showed an anti-apoptotic effect and prevented caspase-3 activation by gp120.	tianeptine	13-23	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	94-99
21175585-11	2011	The mechanism of tianeptine"s action involved GS and cNOS stabilization and iNOS suppression.	tianeptine	17-27	glutamate-ammonia ligase	Homo sapiens	46-48
21175585-11	2011	The mechanism of tianeptine"s action involved GS and cNOS stabilization and iNOS suppression.	tianeptine	17-27	nitric oxide synthase 3	Homo sapiens	53-57
21175585-11	2011	The mechanism of tianeptine"s action involved GS and cNOS stabilization and iNOS suppression.	tianeptine	17-27	nitric oxide synthase 2	Homo sapiens	76-80
21175585-12	2011	Moreover, tianeptine increased IkappaB-alpha levels in the absence of gp120 and blocked its degradation in response to gp120.	tianeptine	10-20	NFKB inhibitor alpha	Homo sapiens	31-44
21175585-12	2011	Moreover, tianeptine increased IkappaB-alpha levels in the absence of gp120 and blocked its degradation in response to gp120.	tianeptine	10-20	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	119-124
21175585-14	2011	CONCLUSIONS AND IMPLICATIONS: Tianeptine clearly exerts neuroprotective effects in vitro by suppressing the molecular pro-inflammatory effects of gp120.	tianeptine	30-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	146-151
20588251-8	2010	Unchanged or slightly increased citrate synthase activity was observed; significant activation of the enzyme was observed after citalopram, tianeptine and olanzapine.	tianeptine	140-150	citrate synthase	Sus scrofa	32-48
21200377-8	2010	MAO-B was inhibited by the following drugs: pargyline > clorgyline > iproniazid > fluoxetine > venlafaxine > amitriptyline > olanzapine > citalopram > desipramine > reboxetine > imipramine > tianeptine > mirtazapine, cocaine >> moclobemide, lithium, valproate.	tianeptine	224-234	monoamine oxidase B	Sus scrofa	0-5
19497431-8	2009	All doses of tianeptine, but especially the 25 mg/kg dose, significantly decreased catalase (CAT) activity in stomach tissue, compared to the control.	tianeptine	13-23	catalase	Rattus norvegicus	83-91
19497431-8	2009	All doses of tianeptine, but especially the 25 mg/kg dose, significantly decreased catalase (CAT) activity in stomach tissue, compared to the control.	tianeptine	13-23	catalase	Rattus norvegicus	93-96
19497431-10	2009	Although all doses of tianeptine significantly decreased the malondialdehyde (MDA) content, all doses of tianeptine, except 6 mg/kg, decreased myeloperoxidase (MPO) activities significantly compared to the control.	tianeptine	105-115	myeloperoxidase	Rattus norvegicus	143-158
19497431-10	2009	Although all doses of tianeptine significantly decreased the malondialdehyde (MDA) content, all doses of tianeptine, except 6 mg/kg, decreased myeloperoxidase (MPO) activities significantly compared to the control.	tianeptine	105-115	myeloperoxidase	Rattus norvegicus	160-163