PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11562965-2	2001	Two synthetic approaches were used for preparation of 8-amino-, 8-methylamino-, and 8-dimethylaminoadenine and -guanine analogs of PME and HPMP series: (a) direct modification of 8-bromopurine acyclic nucleotide analogs at the 8-position of the base, (b) alkylation of 8-modified purine bases with alkylation agents.	8-modified purine	269-286	cystatin B	Homo sapiens	131-134