PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29047162-6	2018	However, we found that daidzin, an ALDH2 antagonist, remarkably attenuated baicalin-elicited inhibitory action on H/R-induced the downregulation of cells viability and Bcl-2 protein expression, and the upregulations of caspase-3 activity, apoptosis rate, cytochrome c and Bax proteins expressions in H9c2 cells.	daidzin	23-30	aldehyde dehydrogenase 2 family member	Rattus norvegicus	35-40
8433985-1	1993	Human mitochondrial aldehyde dehydrogenase (ALDH-I) is potently, reversibly, and selectively inhibited by an isoflavone isolated from Radix puerariae and identified as daidzin, the 7-glucoside of 4",7-dihydroxyisoflavone.	daidzin	168-175	aldehyde dehydrogenase 2 family member	Homo sapiens	44-50
29047162-6	2018	However, we found that daidzin, an ALDH2 antagonist, remarkably attenuated baicalin-elicited inhibitory action on H/R-induced the downregulation of cells viability and Bcl-2 protein expression, and the upregulations of caspase-3 activity, apoptosis rate, cytochrome c and Bax proteins expressions in H9c2 cells.	daidzin	23-30	BCL2, apoptosis regulator	Rattus norvegicus	168-173
35477569-11	2022	NSCLC/PTX cells re-acquired sensitivity to PTX in vivo and in vitro when ALDH2 was inhibited by pharmacological agents, including the ALDH2 inhibitors Daidzin (DZN)/Disulfiram (DSF) and JIB04, which reverses the effect of EHMT2.	daidzin	151-158	aldehyde dehydrogenase 2 family member	Homo sapiens	73-78
34748867-14	2022	The results of PLSR and CCA revealed that the contents of puerarin, daidzin, salvianolic acid B and ginsenoside Rb1 were inversely correlated with the expression of VEGF and HIF-1alpha.	daidzin	68-75	vascular endothelial growth factor A	Rattus norvegicus	165-169
34748867-14	2022	The results of PLSR and CCA revealed that the contents of puerarin, daidzin, salvianolic acid B and ginsenoside Rb1 were inversely correlated with the expression of VEGF and HIF-1alpha.	daidzin	68-75	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	174-184
34748867-16	2022	The results of intervention on primary culture retinal Muller cells showed that puerarin, daidzin, salvianolic acid B, and ginsenoside Rb1 can significantly inhibit the expression of VEGF and HIF-1alpha.	daidzin	90-97	vascular endothelial growth factor A	Rattus norvegicus	183-187
34748867-16	2022	The results of intervention on primary culture retinal Muller cells showed that puerarin, daidzin, salvianolic acid B, and ginsenoside Rb1 can significantly inhibit the expression of VEGF and HIF-1alpha.	daidzin	90-97	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	192-202
34859100-11	2021	Molecular docking results confirmed that daidzein 7-O-glucoside (daidzin) had the highest degree of binding to TNF proteins in the TNF signaling pathway.	daidzin	41-63	tumor necrosis factor	Homo sapiens	111-114
34859100-11	2021	Molecular docking results confirmed that daidzein 7-O-glucoside (daidzin) had the highest degree of binding to TNF proteins in the TNF signaling pathway.	daidzin	41-63	tumor necrosis factor	Homo sapiens	131-134
34859100-11	2021	Molecular docking results confirmed that daidzein 7-O-glucoside (daidzin) had the highest degree of binding to TNF proteins in the TNF signaling pathway.	daidzin	65-72	tumor necrosis factor	Homo sapiens	111-114
34859100-11	2021	Molecular docking results confirmed that daidzein 7-O-glucoside (daidzin) had the highest degree of binding to TNF proteins in the TNF signaling pathway.	daidzin	65-72	tumor necrosis factor	Homo sapiens	131-134
29047162-6	2018	However, we found that daidzin, an ALDH2 antagonist, remarkably attenuated baicalin-elicited inhibitory action on H/R-induced the downregulation of cells viability and Bcl-2 protein expression, and the upregulations of caspase-3 activity, apoptosis rate, cytochrome c and Bax proteins expressions in H9c2 cells.	daidzin	23-30	caspase 3	Rattus norvegicus	219-228
29047162-6	2018	However, we found that daidzin, an ALDH2 antagonist, remarkably attenuated baicalin-elicited inhibitory action on H/R-induced the downregulation of cells viability and Bcl-2 protein expression, and the upregulations of caspase-3 activity, apoptosis rate, cytochrome c and Bax proteins expressions in H9c2 cells.	daidzin	23-30	BCL2 associated X, apoptosis regulator	Rattus norvegicus	272-275
34867009-0	2021	Daidzin inhibits growth and induces apoptosis through the JAK2/STAT3 in human cervical cancer HeLa cells.	daidzin	0-7	Janus kinase 2	Homo sapiens	58-62
34867009-0	2021	Daidzin inhibits growth and induces apoptosis through the JAK2/STAT3 in human cervical cancer HeLa cells.	daidzin	0-7	signal transducer and activator of transcription 3	Homo sapiens	63-68
34360871-8	2021	In silico analysis showed that the main constituents, puerarin and daidzin, had excellent binding affinities for human tyrosinase.	daidzin	67-74	tyrosinase	Homo sapiens	119-129
35477569-11	2022	NSCLC/PTX cells re-acquired sensitivity to PTX in vivo and in vitro when ALDH2 was inhibited by pharmacological agents, including the ALDH2 inhibitors Daidzin (DZN)/Disulfiram (DSF) and JIB04, which reverses the effect of EHMT2.	daidzin	151-158	aldehyde dehydrogenase 2 family member	Homo sapiens	134-139
35477569-11	2022	NSCLC/PTX cells re-acquired sensitivity to PTX in vivo and in vitro when ALDH2 was inhibited by pharmacological agents, including the ALDH2 inhibitors Daidzin (DZN)/Disulfiram (DSF) and JIB04, which reverses the effect of EHMT2.	daidzin	151-158	euchromatic histone lysine methyltransferase 2	Homo sapiens	222-227
35477569-11	2022	NSCLC/PTX cells re-acquired sensitivity to PTX in vivo and in vitro when ALDH2 was inhibited by pharmacological agents, including the ALDH2 inhibitors Daidzin (DZN)/Disulfiram (DSF) and JIB04, which reverses the effect of EHMT2.	daidzin	160-163	aldehyde dehydrogenase 2 family member	Homo sapiens	73-78
35477569-11	2022	NSCLC/PTX cells re-acquired sensitivity to PTX in vivo and in vitro when ALDH2 was inhibited by pharmacological agents, including the ALDH2 inhibitors Daidzin (DZN)/Disulfiram (DSF) and JIB04, which reverses the effect of EHMT2.	daidzin	160-163	aldehyde dehydrogenase 2 family member	Homo sapiens	134-139
35477569-11	2022	NSCLC/PTX cells re-acquired sensitivity to PTX in vivo and in vitro when ALDH2 was inhibited by pharmacological agents, including the ALDH2 inhibitors Daidzin (DZN)/Disulfiram (DSF) and JIB04, which reverses the effect of EHMT2.	daidzin	160-163	euchromatic histone lysine methyltransferase 2	Homo sapiens	222-227
35181309-0	2022	Daidzin targets epithelial-to-mesenchymal transition process by attenuating manganese superoxide dismutase expression and PI3K/Akt/mTOR activation in tumor cells.	daidzin	0-7	superoxide dismutase 2	Homo sapiens	76-106
35181309-0	2022	Daidzin targets epithelial-to-mesenchymal transition process by attenuating manganese superoxide dismutase expression and PI3K/Akt/mTOR activation in tumor cells.	daidzin	0-7	AKT serine/threonine kinase 1	Homo sapiens	127-130
35181309-0	2022	Daidzin targets epithelial-to-mesenchymal transition process by attenuating manganese superoxide dismutase expression and PI3K/Akt/mTOR activation in tumor cells.	daidzin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	131-135
35181309-12	2022	DDZ treatment also modulated activation of PI3K/Akt/mTOR signaling cascades in DU145 cells.	daidzin	0-3	AKT serine/threonine kinase 1	Homo sapiens	48-51
35181309-12	2022	DDZ treatment also modulated activation of PI3K/Akt/mTOR signaling cascades in DU145 cells.	daidzin	0-3	mechanistic target of rapamycin kinase	Homo sapiens	52-56
35181309-15	2022	Our data indicated that DDZ might act as a potent suppressor of EMT by affecting MnSOD expression in tumor cells.	daidzin	24-27	superoxide dismutase 2	Homo sapiens	81-86
32450180-0	2020	Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.	daidzin	27-34	brain derived neurotrophic factor	Mus musculus	95-99
33865968-8	2021	Mag could enhance the activity of recombinant human ALDH2 proteins with a half-maximal effective concentration of 5.79 x 10 M. In addition, ALDH2 activation via Alda-1 inhibited cardiac fibroblast proliferation and collagen synthesis, while ALDH2 inhibition via daidzin partially blocked the suppressive effects of Mag.	daidzin	262-269	aldehyde dehydrogenase 2 family member	Homo sapiens	52-57
33865968-8	2021	Mag could enhance the activity of recombinant human ALDH2 proteins with a half-maximal effective concentration of 5.79 x 10 M. In addition, ALDH2 activation via Alda-1 inhibited cardiac fibroblast proliferation and collagen synthesis, while ALDH2 inhibition via daidzin partially blocked the suppressive effects of Mag.	daidzin	262-269	aldehyde dehydrogenase 2 family member	Homo sapiens	140-145
33865968-8	2021	Mag could enhance the activity of recombinant human ALDH2 proteins with a half-maximal effective concentration of 5.79 x 10 M. In addition, ALDH2 activation via Alda-1 inhibited cardiac fibroblast proliferation and collagen synthesis, while ALDH2 inhibition via daidzin partially blocked the suppressive effects of Mag.	daidzin	262-269	aldehyde dehydrogenase 2 family member	Homo sapiens	140-145
33839903-3	2021	Previous studies have described that synthetic derivatives from the natural isoflavone daidzin can modulate cocaine addiction, by a mechanism suggested to involve aldehyde-dehydrogenase (ALDH) activities.	daidzin	87-94	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	163-185
33839903-3	2021	Previous studies have described that synthetic derivatives from the natural isoflavone daidzin can modulate cocaine addiction, by a mechanism suggested to involve aldehyde-dehydrogenase (ALDH) activities.	daidzin	87-94	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	187-191
35284766-2	2022	Here, we investigated the binding poses and strengths of eight isoflavone analogues (including CVT-10216 and daidzin) with ALDH2 via computational methods of molecular docking, molecular dynamics (MD) simulation, molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), steered MD, and umbrella sampling.	daidzin	109-116	aldehyde dehydrogenase 2 family member	Homo sapiens	123-128
35118741-0	2022	Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1.	daidzin	0-7	triosephosphate isomerase 1	Homo sapiens	134-138
35118741-8	2022	The expressions of CDK1, BCL2, MYC, and survivin were reduced, while the expressions of BAX and PARP were increased in DDZ treated cells.	daidzin	119-122	cyclin dependent kinase 1	Homo sapiens	19-23
35118741-8	2022	The expressions of CDK1, BCL2, MYC, and survivin were reduced, while the expressions of BAX and PARP were increased in DDZ treated cells.	daidzin	119-122	BCL2 apoptosis regulator	Homo sapiens	25-29
35118741-8	2022	The expressions of CDK1, BCL2, MYC, and survivin were reduced, while the expressions of BAX and PARP were increased in DDZ treated cells.	daidzin	119-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-34
35118741-8	2022	The expressions of CDK1, BCL2, MYC, and survivin were reduced, while the expressions of BAX and PARP were increased in DDZ treated cells.	daidzin	119-122	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
35118741-8	2022	The expressions of CDK1, BCL2, MYC, and survivin were reduced, while the expressions of BAX and PARP were increased in DDZ treated cells.	daidzin	119-122	collagen type XI alpha 2 chain	Homo sapiens	96-100
35118741-10	2022	Bioinformatic analysis identified TPI1, a gene in the glycolysis pathway with prognostic value for hepatocellular carcinoma (HCC), and DDZ treatment downregulated this gene.	daidzin	135-138	triosephosphate isomerase 1	Homo sapiens	34-38
35118741-12	2022	This study shows that DDZ interfered with the survival and migration of hepatocellular carcinoma cells, likely via TPI1 and the gluconeogenesis pathway.	daidzin	22-25	triosephosphate isomerase 1	Homo sapiens	115-119
6538542-0	1984	Oestrogenic response of the CD-1 mouse to the soya-bean isoflavones genistein, genistin and daidzin.	daidzin	92-99	CD1 antigen complex	Mus musculus	28-32
33360016-7	2021	An activator (Alda-1) and an inhibitor (daidzin) of ALDH2 were used, to determine if this enzyme activity is related to aldosterone effects, through possible modulation of ROS.	daidzin	40-47	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	52-57
32450180-0	2020	Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.	daidzin	27-34	vascular endothelial growth factor A	Mus musculus	100-104
32450180-14	2020	Moreover, the molecular docking results showed that daidzin possesses a better binding affinity for ALDH2, estrogen receptor-beta, P13k, AKT2, mTORC1, and HIF-1-alpha proteins.	daidzin	52-59	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	100-105
32450180-14	2020	Moreover, the molecular docking results showed that daidzin possesses a better binding affinity for ALDH2, estrogen receptor-beta, P13k, AKT2, mTORC1, and HIF-1-alpha proteins.	daidzin	52-59	estrogen receptor 1 (alpha)	Mus musculus	107-129
32450180-14	2020	Moreover, the molecular docking results showed that daidzin possesses a better binding affinity for ALDH2, estrogen receptor-beta, P13k, AKT2, mTORC1, and HIF-1-alpha proteins.	daidzin	52-59	thymoma viral proto-oncogene 2	Mus musculus	137-141
32450180-14	2020	Moreover, the molecular docking results showed that daidzin possesses a better binding affinity for ALDH2, estrogen receptor-beta, P13k, AKT2, mTORC1, and HIF-1-alpha proteins.	daidzin	52-59	CREB regulated transcription coactivator 1	Mus musculus	143-149
32450180-14	2020	Moreover, the molecular docking results showed that daidzin possesses a better binding affinity for ALDH2, estrogen receptor-beta, P13k, AKT2, mTORC1, and HIF-1-alpha proteins.	daidzin	52-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	155-166
32450180-15	2020	Taken together, the results of the present study showed that daidzin has remarkable neuroprotective and anti-epileptic properties through modulation of oxidative stress, BDNF/VEGF, and apoptotic signaling in the brain tissue of PTZ-kindled mice.	daidzin	61-68	brain derived neurotrophic factor	Mus musculus	170-174
32450180-15	2020	Taken together, the results of the present study showed that daidzin has remarkable neuroprotective and anti-epileptic properties through modulation of oxidative stress, BDNF/VEGF, and apoptotic signaling in the brain tissue of PTZ-kindled mice.	daidzin	61-68	vascular endothelial growth factor A	Mus musculus	175-179
31034797-6	2019	In addition, daidzin was further identified to induce expression of tetrameric globular form of proline-rich membrane anchor (PRiMA)-linked AChE.	daidzin	13-20	proline rich membrane anchor 1	Rattus norvegicus	126-131
32811404-0	2020	Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin.	daidzin	111-118	aldehyde dehydrogenase 2 family member	Homo sapiens	66-90
32811404-2	2020	OBJECTIVE: In the present study, we investigated the molecular basis for the selective inhibition of ALDH-2 by the antioxidant isoflavonoid daidzin (IC50= 0.15 muM) compared to isoform 1 of ALDH through molecular dynamics studies and semiempirical calculations of the en-thalpy of interaction.	daidzin	140-147	aldehyde dehydrogenase 2 family member	Homo sapiens	101-107
32811404-3	2020	METHODS: The applied methodology consisted of performing the molecular docking of daidzin in the structures of ALDH-1 and ALDH-2 and submitting the lower energy complexes obtained to semiempirical calculations and dynamic molecular simulations.	daidzin	82-89	aldehyde dehydrogenase 1 family member A1	Homo sapiens	111-117
32811404-3	2020	METHODS: The applied methodology consisted of performing the molecular docking of daidzin in the structures of ALDH-1 and ALDH-2 and submitting the lower energy complexes obtained to semiempirical calculations and dynamic molecular simulations.	daidzin	82-89	aldehyde dehydrogenase 2 family member	Homo sapiens	122-128
32811404-4	2020	RESULTS: Daidzin in complex with ALDH-2 presented directed and more specific interactions, resulting in stronger bonds in energetic terms and, therefore, in enthalpic gain.	daidzin	9-16	aldehyde dehydrogenase 2 family member	Homo sapiens	33-39
31878046-0	2019	Attenuation of STAT3 Signaling Cascade by Daidzin Can Enhance the Apoptotic Potential of Bortezomib against Multiple Myeloma.	daidzin	42-49	signal transducer and activator of transcription 3	Homo sapiens	15-20
31878046-4	2019	Here, we noted that DDZ abrogated STAT3 activation (both constitutive as well as inducible) at Tyr705 and Ser727 in MM cells.	daidzin	20-23	signal transducer and activator of transcription 3	Homo sapiens	34-39
31878046-5	2019	Additionally, DDZ mitigated the phosphorylation of STAT3 upstream Janus-activated kinases (JAK1/2) and c-Src kinases.	daidzin	14-17	signal transducer and activator of transcription 3	Homo sapiens	51-56
31878046-5	2019	Additionally, DDZ mitigated the phosphorylation of STAT3 upstream Janus-activated kinases (JAK1/2) and c-Src kinases.	daidzin	14-17	Janus kinase 1	Homo sapiens	91-97
31878046-5	2019	Additionally, DDZ mitigated the phosphorylation of STAT3 upstream Janus-activated kinases (JAK1/2) and c-Src kinases.	daidzin	14-17	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	103-108
31878046-6	2019	Pervanadate (tyrosine phosphatase blocker) exposure altered the DDZ-induced inhibition of STAT3 activation, thus affecting the action of this phytoestrogen on apoptosis.	daidzin	64-67	signal transducer and activator of transcription 3	Homo sapiens	90-95
31878046-8	2019	Overall, the data indicate that DDZ may act as a potent suppressor of STAT3 signaling cascade, and the co-treatment of DDZ and Bor could be a promising therapeutic strategy, specifically in MM.	daidzin	32-35	signal transducer and activator of transcription 3	Homo sapiens	70-75
32475100-12	2020	And Wnt-1 and beta-catenin were higher in the Daidzin group than those in the Control group.	daidzin	46-53	Wnt family member 1	Rattus norvegicus	4-9
32475100-12	2020	And Wnt-1 and beta-catenin were higher in the Daidzin group than those in the Control group.	daidzin	46-53	catenin beta 1	Rattus norvegicus	14-26
32475100-14	2020	Caveolin-1, Wnt-1 and beta-catenin in lung tissues also markedly declined in the Daidzin group compared with those in the COPD group.	daidzin	81-88	caveolin 1	Rattus norvegicus	0-10
32475100-14	2020	Caveolin-1, Wnt-1 and beta-catenin in lung tissues also markedly declined in the Daidzin group compared with those in the COPD group.	daidzin	81-88	Wnt family member 1	Rattus norvegicus	12-17
32475100-14	2020	Caveolin-1, Wnt-1 and beta-catenin in lung tissues also markedly declined in the Daidzin group compared with those in the COPD group.	daidzin	81-88	catenin beta 1	Rattus norvegicus	22-34
31689484-6	2020	Daidzin, the antagonist of ALDH2 abolished the role of Alda-1.	daidzin	0-7	aldehyde dehydrogenase 2 family member	Rattus norvegicus	27-32
31034797-6	2019	In addition, daidzin was further identified to induce expression of tetrameric globular form of proline-rich membrane anchor (PRiMA)-linked AChE.	daidzin	13-20	acetylcholinesterase	Rattus norvegicus	140-144
30562628-5	2019	Moreover, the intestinal absorption of puerarin and daidzin could be improved by GR extract and inhibitors of P-glycoprotein and multidrug resistanceassociated protein 2, respectively.	daidzin	52-59	ATP binding cassette subfamily C member 2	Rattus norvegicus	129-169
30378146-0	2019	Daidzin inhibits RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced bone loss in vivo.	daidzin	0-7	TNF superfamily member 11	Homo sapiens	17-22
30378146-5	2019	In this study, our study showed that daidzin significantly inhibited receptor activator of nuclear factor-kB ligand (RANKL)-induced osteoclast differentiation of bone marrow macrophages and the hydroxyapatite-resorbing activity of mature osteoclasts by inhibiting RANKL-induced NF-kB signaling pathway.	daidzin	37-44	TNF superfamily member 11	Homo sapiens	69-115
30378146-5	2019	In this study, our study showed that daidzin significantly inhibited receptor activator of nuclear factor-kB ligand (RANKL)-induced osteoclast differentiation of bone marrow macrophages and the hydroxyapatite-resorbing activity of mature osteoclasts by inhibiting RANKL-induced NF-kB signaling pathway.	daidzin	37-44	TNF superfamily member 11	Homo sapiens	117-122
30378146-5	2019	In this study, our study showed that daidzin significantly inhibited receptor activator of nuclear factor-kB ligand (RANKL)-induced osteoclast differentiation of bone marrow macrophages and the hydroxyapatite-resorbing activity of mature osteoclasts by inhibiting RANKL-induced NF-kB signaling pathway.	daidzin	37-44	TNF superfamily member 11	Homo sapiens	264-269
30378146-6	2019	In addition, daidzin could inhibit the expression of osteoclast marker genes, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), cellular oncogene fos (c-Fos), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CTSK).	daidzin	13-20	nuclear factor of activated T cells 1	Homo sapiens	88-137
30378146-6	2019	In addition, daidzin could inhibit the expression of osteoclast marker genes, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), cellular oncogene fos (c-Fos), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CTSK).	daidzin	13-20	nuclear factor of activated T cells 1	Homo sapiens	139-145
30378146-6	2019	In addition, daidzin could inhibit the expression of osteoclast marker genes, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), cellular oncogene fos (c-Fos), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CTSK).	daidzin	13-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	148-169
30378146-6	2019	In addition, daidzin could inhibit the expression of osteoclast marker genes, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), cellular oncogene fos (c-Fos), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CTSK).	daidzin	13-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-176
30378146-6	2019	In addition, daidzin could inhibit the expression of osteoclast marker genes, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), cellular oncogene fos (c-Fos), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CTSK).	daidzin	13-20	cathepsin K	Homo sapiens	227-238
30378146-6	2019	In addition, daidzin could inhibit the expression of osteoclast marker genes, including nuclear factor of activated T cells cytoplasmic 1 (NFATc1), cellular oncogene fos (c-Fos), tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CTSK).	daidzin	13-20	cathepsin K	Homo sapiens	240-244
30378146-8	2019	Together our data demonstrated that daidzin inhibits RANKL-induced osteoclastogenesis through suppressing NF-kB signaling pathway and that daidzin is a promising agent in the treatment of osteolytic diseases.	daidzin	36-43	TNF superfamily member 11	Homo sapiens	53-58
30801261-6	2019	Moreover, application of Smad2/3 inhibitor alleviated TGF-beta1-induced HCF differentiation and improved ALDH2 activity, which was reversed by the application of ALDH2 inhibitor daidzin.	daidzin	178-185	SMAD family member 2	Homo sapiens	25-32
30801261-6	2019	Moreover, application of Smad2/3 inhibitor alleviated TGF-beta1-induced HCF differentiation and improved ALDH2 activity, which was reversed by the application of ALDH2 inhibitor daidzin.	daidzin	178-185	transforming growth factor beta 1	Homo sapiens	54-63
30801261-6	2019	Moreover, application of Smad2/3 inhibitor alleviated TGF-beta1-induced HCF differentiation and improved ALDH2 activity, which was reversed by the application of ALDH2 inhibitor daidzin.	daidzin	178-185	aldehyde dehydrogenase 2 family member	Homo sapiens	105-110
30801261-6	2019	Moreover, application of Smad2/3 inhibitor alleviated TGF-beta1-induced HCF differentiation and improved ALDH2 activity, which was reversed by the application of ALDH2 inhibitor daidzin.	daidzin	178-185	aldehyde dehydrogenase 2 family member	Homo sapiens	162-167
29300716-10	2018	Additionally, there were significant decreases in the serum levels of CRP and GAG and increases in ALP in the DZN-treated groups compared to the negative control group.	daidzin	110-113	C-reactive protein	Rattus norvegicus	70-73
30538807-9	2018	We observed a decrease in mitochondrial respiration and reserve capacity that coincided with SA-beta-Gal accumulation and an increase in p21 and p53 expression in siALDH2 or daidzin-treated HUVECs.	daidzin	174-181	dacapo	Drosophila melanogaster	137-140
30538807-9	2018	We observed a decrease in mitochondrial respiration and reserve capacity that coincided with SA-beta-Gal accumulation and an increase in p21 and p53 expression in siALDH2 or daidzin-treated HUVECs.	daidzin	174-181	p53	Drosophila melanogaster	145-148
30187866-7	2018	Blocking ALDH2 with Daidzin produced similar effects to H 2O 2 exposure on theviability, oxidative stress level, and ALDH2 activity and expression in the myocardial cells.	daidzin	20-27	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	9-14
30187866-7	2018	Blocking ALDH2 with Daidzin produced similar effects to H 2O 2 exposure on theviability, oxidative stress level, and ALDH2 activity and expression in the myocardial cells.	daidzin	20-27	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	117-122
28858301-11	2018	All the ox-LDL-induced responses were significantly attenuated in the presence of Alda-1 (an ALDH2 activating agent), and accentuated in the presence of daidzin (an ALDH2 inhibitor).	daidzin	153-160	aldehyde dehydrogenase 2 family member	Homo sapiens	165-170
27679490-8	2016	Formation of NO and cGMP accumulation were inhibited by ALDH inhibitors chloral hydrate and daidzin.	daidzin	92-99	aldehyde dehydrogenase 2 family member	Homo sapiens	56-60
28251688-7	2017	Daidzin, an inhibitor of ALDH2, significantly antagonizes FA-exerted cytotoxicity and oxidative stress including the accumulation of intracellular reactive oxygen species (ROS), 4-hydroxy-2-trans-nonenal (4-HNE), and malondialdehyde (MDA), in PC12 cells.	daidzin	0-7	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	25-30
28219011-2	2017	In this study, we further characterized the inhibition of four psoralen and coumarin derivatives toward ALDH2 and compared them to the ALDH2 inhibitor daidzin for selectivity against five ALDH1/2 isoenzymes.	daidzin	151-158	aldehyde dehydrogenase 2 family member	Homo sapiens	135-140
28219011-2	2017	In this study, we further characterized the inhibition of four psoralen and coumarin derivatives toward ALDH2 and compared them to the ALDH2 inhibitor daidzin for selectivity against five ALDH1/2 isoenzymes.	daidzin	151-158	aldehyde dehydrogenase 1 family member A1	Homo sapiens	188-193
28698467-4	2017	MICs of daidzin, genistin, daidzein, and genistein were >2048 mug mL-1 for all strains assayed, while that of equol ranged from 16 mug mL-1 for Bifidobacterium animalis subsp.	daidzin	8-15	L1 cell adhesion molecule	Mus musculus	69-73
28831294-5	2017	Daidzin treatment reduced all kidney injury markers (NGAL, BUN, creatinine, and KIM-1) and attenuated cell death (apoptotic markers).	daidzin	0-7	lipocalin 2	Mus musculus	53-57
28831294-5	2017	Daidzin treatment reduced all kidney injury markers (NGAL, BUN, creatinine, and KIM-1) and attenuated cell death (apoptotic markers).	daidzin	0-7	hepatitis A virus cellular receptor 1	Mus musculus	80-85
25354921-7	2015	Protection against thermal denaturation and competition with daidzin suggested that tamoxifen binds to the aldehyde site of ALDH1A1, resembling the interaction of N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide with ALDH2.	daidzin	61-68	aldehyde dehydrogenase 1 family member A1	Homo sapiens	124-131
26916499-5	2016	From the results of the molecular docking studies performed herein and their relationships with the inhibitory profiles of some daidzin analogs described previously in the literature, pharmacophore groups associated with ALDH-2 enzyme recognition were identified.	daidzin	128-135	aldehyde dehydrogenase 2 family member	Homo sapiens	221-227
27367654-8	2016	Puerarin and daidzin are the major constituents of Gegen, and the pharmacokinetics of G-1 and G-2 puerarin conformed with the two compartment open model, while for G-3 and G-4, they conformed to a one compartment open model.	daidzin	13-20	myosin regulatory light chain 2, skeletal muscle isoform type 2	Oryctolagus cuniculus	86-97
27078577-7	2016	To prevent metabolism of nicorandil, an approved drug in Europe for the treatment of angina, cultured sensory neurons were pretreated with nicorandil and daidzin, an aldehyde dehydrogenase 2 inhibitor, resulting in decreased DNA damage but not altered transmitter release by cisplatin.	daidzin	154-161	aldehyde dehydrogenase 2 family member	Homo sapiens	166-190
26916499-2	2016	Several studies involving the synthesis, the design and pharmacological evaluation of daidzin (isoflavonoid inhibitor of ALDH-2) analogs were conducted.	daidzin	86-93	aldehyde dehydrogenase 2 family member	Homo sapiens	121-127
25084483-8	2014	Daidzin, an ALDH2 inhibitor, was used to clarify the mechanisms of rutin"s protective effects.	daidzin	0-7	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	12-17
25005621-6	2014	We also showed that MPP(+) up-regulates the expression and activity of ALDH2 in PC12 cells and that inhibition of ALDH2 by its specific inhibitor daidzin prevents MPP(+)-induced decrease in cell viability and increases in apoptosis, oxidative stress and aldehyde stress in PC12 cells.	daidzin	146-153	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	71-76
25005621-6	2014	We also showed that MPP(+) up-regulates the expression and activity of ALDH2 in PC12 cells and that inhibition of ALDH2 by its specific inhibitor daidzin prevents MPP(+)-induced decrease in cell viability and increases in apoptosis, oxidative stress and aldehyde stress in PC12 cells.	daidzin	146-153	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	114-119
23557122-1	2013	A novel drug delivery system, TPGS 1000 (TPGS) emulsified zein nanoparticles (TZN), were designed with an objective to improve the oral bioavailability of daidzin, an isoflavone glycoside with estrogenic activities.	daidzin	155-162	zinc finger protein 37	Mus musculus	78-81
23557122-6	2013	Daidzin loaded TZN had a slower daidzin release compared with daidzin loaded ZN in both simulated digestive fluids and a pH 7.4 buffer.	daidzin	0-7	zinc finger protein 37	Mus musculus	15-18
23557122-6	2013	Daidzin loaded TZN had a slower daidzin release compared with daidzin loaded ZN in both simulated digestive fluids and a pH 7.4 buffer.	daidzin	32-39	zinc finger protein 37	Mus musculus	15-18
23557122-8	2013	Cellular uptake and transport studies revealed that daidzin in TZN were taken up more efficiently into Caco-2 cells and transported more quickly through Caco-2 monolayer than daidzin solution.	daidzin	52-59	zinc finger protein 37	Mus musculus	63-66
23557122-8	2013	Cellular uptake and transport studies revealed that daidzin in TZN were taken up more efficiently into Caco-2 cells and transported more quickly through Caco-2 monolayer than daidzin solution.	daidzin	175-182	zinc finger protein 37	Mus musculus	63-66
23557122-9	2013	A pharmacokinetic study demonstrated that the Cmax of daidzein in mice after oral administration of daidzin loaded TZN was 5.66 +- 0.16 muM, which was improved by 2.64-fold compared with that of daidzin solution (2.14 +- 0.04 muM).	daidzin	100-107	zinc finger protein 37	Mus musculus	115-118
23557122-10	2013	Moreover, the areas under the curve (AUC0-12 h) for daidzin loaded in TZN were enhanced by 2.4-fold compared with that of daidzin solution.	daidzin	52-59	zinc finger protein 37	Mus musculus	70-73
23557122-11	2013	These results suggested that TZN could be an effective strategy to improve the oral bioavailability of isoflavone glycosides like daidzin.	daidzin	130-137	zinc finger protein 37	Mus musculus	29-32
21123025-2	2011	This study was aimed at investigating the role of ALDH2 in antimycin A-induced cardiomyocytes apoptosis by suppressing ALDH2 activity with a specific ALDH2 inhibitor Daidzin.	daidzin	166-173	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	50-55
24324516-4	2013	Here, we report that 7,3",4"-trihydroxyisoflavone (7,3",4"-THIF), a major metabolite of daidzin, effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)- alpha , and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced beta -hexosaminidase secretion in RBL-2H3 cells.	daidzin	88-95	thioredoxin interacting protein	Mus musculus	59-63
24324516-4	2013	Here, we report that 7,3",4"-trihydroxyisoflavone (7,3",4"-THIF), a major metabolite of daidzin, effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)- alpha , and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced beta -hexosaminidase secretion in RBL-2H3 cells.	daidzin	88-95	tumor necrosis factor	Mus musculus	171-205
24324516-4	2013	Here, we report that 7,3",4"-trihydroxyisoflavone (7,3",4"-THIF), a major metabolite of daidzin, effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)- alpha , and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced beta -hexosaminidase secretion in RBL-2H3 cells.	daidzin	88-95	interleukin 6	Mus musculus	212-230
24324516-4	2013	Here, we report that 7,3",4"-trihydroxyisoflavone (7,3",4"-THIF), a major metabolite of daidzin, effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)- alpha , and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced beta -hexosaminidase secretion in RBL-2H3 cells.	daidzin	88-95	O-GlcNAcase	Mus musculus	279-299
21123025-2	2011	This study was aimed at investigating the role of ALDH2 in antimycin A-induced cardiomyocytes apoptosis by suppressing ALDH2 activity with a specific ALDH2 inhibitor Daidzin.	daidzin	166-173	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	119-124
21123025-2	2011	This study was aimed at investigating the role of ALDH2 in antimycin A-induced cardiomyocytes apoptosis by suppressing ALDH2 activity with a specific ALDH2 inhibitor Daidzin.	daidzin	166-173	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	119-124
21123025-4	2011	Daidzin (60muM) effectively inhibited ALDH2 activity by 50% without own effect on cell apoptosis, and significantly enhanced antimycin A-induced cardiomyocytes apoptosis from 33.5+-4.4 to 56.5+-6.4% (Hochest method, p<0.05), and from 57.9+-1.9 to 74.0+-11.9% (FACS, p<0.05).	daidzin	0-7	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	38-43
21123025-5	2011	Phosphorylation of activated MAPK signaling pathway, including extracellular signal-regulated kinase (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 was also increased in antimycin A and daidzin treated cardiomyocytes compared to the cells treated with antimycin A alone.	daidzin	189-196	mitogen activated protein kinase 3	Rattus norvegicus	29-33
21123025-5	2011	Phosphorylation of activated MAPK signaling pathway, including extracellular signal-regulated kinase (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 was also increased in antimycin A and daidzin treated cardiomyocytes compared to the cells treated with antimycin A alone.	daidzin	189-196	mitogen activated protein kinase 3	Rattus norvegicus	102-108
21123025-5	2011	Phosphorylation of activated MAPK signaling pathway, including extracellular signal-regulated kinase (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 was also increased in antimycin A and daidzin treated cardiomyocytes compared to the cells treated with antimycin A alone.	daidzin	189-196	mitogen-activated protein kinase 8	Rattus norvegicus	111-136
21123025-5	2011	Phosphorylation of activated MAPK signaling pathway, including extracellular signal-regulated kinase (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 was also increased in antimycin A and daidzin treated cardiomyocytes compared to the cells treated with antimycin A alone.	daidzin	189-196	mitogen-activated protein kinase 8	Rattus norvegicus	138-141
21123025-5	2011	Phosphorylation of activated MAPK signaling pathway, including extracellular signal-regulated kinase (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38 was also increased in antimycin A and daidzin treated cardiomyocytes compared to the cells treated with antimycin A alone.	daidzin	189-196	mitogen activated protein kinase 14	Rattus norvegicus	147-150
21459068-6	2011	Rings treated with daidzin (10 mumol/L), an ALDH2 inhibitor, potentiated contractile responses to phenylephrine (PE) in AngII mice.	daidzin	19-26	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	44-49
22108408-6	2011	Daidzin showed basolateral-to-apical transport and the absorption extent could be reduced by 50% in the presence of MK571, a multidrug resistance-associated protein inhibitor (MRP).	daidzin	0-7	ATP binding cassette subfamily C member 2	Rattus norvegicus	125-174
22108408-6	2011	Daidzin showed basolateral-to-apical transport and the absorption extent could be reduced by 50% in the presence of MK571, a multidrug resistance-associated protein inhibitor (MRP).	daidzin	0-7	ATP binding cassette subfamily C member 2	Rattus norvegicus	176-179
21562980-1	2011	A Gram-negative anaerobic microorganism, MRG-1, isolated from human intestine showed high activities of deglycosylation and reduction of daidzin, based on rapid TLC analysis.	daidzin	137-144	mortality factor 4 like 1 pseudogene 1	Homo sapiens	41-46
21459068-6	2011	Rings treated with daidzin (10 mumol/L), an ALDH2 inhibitor, potentiated contractile responses to phenylephrine (PE) in AngII mice.	daidzin	19-26	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	120-125
21052945-3	2010	Moreover, the ameliorating effects of daidzin or daidzein were antagonized by tamoxifen (1 mg/kg), the nonspecific estrogen receptor antagonist.	daidzin	38-45	estrogen receptor 1 (alpha)	Mus musculus	115-132
21052945-4	2010	These results indicate that daidzin or daidzein may be useful in cognitive impairment induced by cholinergic dysfunction, and this beneficial effect is mediated, in part, via estrogen receptor.	daidzin	28-35	estrogen receptor 1 (alpha)	Mus musculus	175-192
16965913-8	2006	EQL has the strongest binding affinities and estrogenic activities especially for ERbeta among the daidzin metabolites and shows the ability to suppress osteoclast formation at high doses.	daidzin	99-106	estrogen receptor 2	Homo sapiens	82-88
19107740-1	2009	This study examined the effects of daidzin, a major isoflavone from Puerariae Radix, on D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced liver failure.	daidzin	35-42	galanin and GMAP prepropeptide	Mus musculus	107-111
19107740-3	2009	Daidzin markedly reduced the elevated serum aminotransferase activity and the levels of lipid peroxidation and tumor necrosis factor-alpha.	daidzin	0-7	tumor necrosis factor	Mus musculus	111-138
19107740-5	2009	The daidzin pretreatment attenuated the swollen mitochondria observed in the d-GalN/LPS group.	daidzin	4-11	galanin and GMAP prepropeptide	Mus musculus	79-83
19107740-6	2009	Daidzin attenuated the apoptosis of hepatocytes, which was confirmed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and a caspase-3 assay.	daidzin	0-7	caspase 3	Mus musculus	162-171
19421368-9	2009	This result was consistent with the in vitro data that daidzein (a metabolite of daidzin), at a concentration of 10 muM, increased IL-2, IL-4, and IFN-gamma production from phytohemagglutinin-stimulated PBMC (P < 0.05).	daidzin	81-88	interleukin 2	Mus musculus	131-135
19421368-9	2009	This result was consistent with the in vitro data that daidzein (a metabolite of daidzin), at a concentration of 10 muM, increased IL-2, IL-4, and IFN-gamma production from phytohemagglutinin-stimulated PBMC (P < 0.05).	daidzin	81-88	interleukin 4	Mus musculus	137-141
19421368-9	2009	This result was consistent with the in vitro data that daidzein (a metabolite of daidzin), at a concentration of 10 muM, increased IL-2, IL-4, and IFN-gamma production from phytohemagglutinin-stimulated PBMC (P < 0.05).	daidzin	81-88	interferon gamma	Mus musculus	147-156
18613661-3	2008	The natural product 7-O-glucosyl-4"-hydroxyisoflavone (daidzin), isolated from the kudzu vine ( Peruraria lobata), is a specific inhibitor of ALDH2 and suppresses ethanol consumption.	daidzin	20-53	aldehyde dehydrogenase 2 family member	Homo sapiens	142-147
18613661-3	2008	The natural product 7-O-glucosyl-4"-hydroxyisoflavone (daidzin), isolated from the kudzu vine ( Peruraria lobata), is a specific inhibitor of ALDH2 and suppresses ethanol consumption.	daidzin	55-62	aldehyde dehydrogenase 2 family member	Homo sapiens	142-147
17849275-3	2007	Therefore, we examined the effects of individual isoflavones (daidzein, daidzin, genistein, and genistin) on the LPS-induced production of TNF-alpha.	daidzin	72-79	tumor necrosis factor	Mus musculus	139-148
17849275-4	2007	Intraperitoneal injections of daidzein, daidzin, and genistin (but not of genistein before a challenge with LPS) resulted in significant depression of serum levels of TNF-alpha in mice.	daidzin	40-47	tumor necrosis factor	Mus musculus	167-176
20828325-4	2010	In addition, COS lactate salt dose-dependently increased acetaldehyde dehydrogenase (ALDH) activity in vitro and reversed the ALDH inhibition induced by daidzin.	daidzin	153-160	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	57-83
20828325-4	2010	In addition, COS lactate salt dose-dependently increased acetaldehyde dehydrogenase (ALDH) activity in vitro and reversed the ALDH inhibition induced by daidzin.	daidzin	153-160	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	85-89
20828325-4	2010	In addition, COS lactate salt dose-dependently increased acetaldehyde dehydrogenase (ALDH) activity in vitro and reversed the ALDH inhibition induced by daidzin.	daidzin	153-160	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	126-130
19448904-3	2009	E1 and E2 were rich in isoflavones (daidzin, glycitin, genistin, malonyldaidzin, malonylglycitin, malonylgenistin, daidzein, glycitein, and genistein).	daidzin	36-43	small nucleolar RNA, H/ACA box 73A	Homo sapiens	0-9
18613661-5	2008	The structure of daidzin/ALDH2 in complex at 2.4 A resolution shows the isoflavone moiety of daidzin binding close to the aldehyde substrate-binding site in a hydrophobic cleft and the glucosyl function binding to a hydrophobic patch immediately outside the isoflavone-binding pocket.	daidzin	17-24	aldehyde dehydrogenase 2 family member	Homo sapiens	25-30
18069788-6	2008	Both BglH and YckE hydrolyzed genistin and daidzin into their isoflavone aglycones, genistein and daidzein, but BglH was more efficient than YckE in isoflavone glucoside hydrolysis (20-fold higher kcat).	daidzin	43-50	aryl-phospho-beta-d-glucosidase	Bacillus subtilis subsp. subtilis str. 168	5-9
18069788-6	2008	Both BglH and YckE hydrolyzed genistin and daidzin into their isoflavone aglycones, genistein and daidzein, but BglH was more efficient than YckE in isoflavone glucoside hydrolysis (20-fold higher kcat).	daidzin	43-50	aryl-phospho-beta-d-glucosidase	Bacillus subtilis subsp. subtilis str. 168	112-116
12601671-3	2003	Fujiflavone P40 contains 46.6% isoflavones which consist of 24.1% daidzin, 16.5% glycitin and 5.9% genistin.	daidzin	66-73	40S ribosomal protein SA	Glycine max	12-15
15377279-5	2005	The selective ALDH2 inhibitor, daidzin (0.1 mM), increased the EC50 of GTN to 7.47+/-0.93 microM.	daidzin	31-38	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	14-19
15377279-7	2005	However, since co-incubation of sGC with purified ALDH2 led to significant stimulation of cGMP formation by GTN that was completely inhibited by 0.1 mM daidzin and NO scavengers, ALDH2 may convert GTN directly into NO or a related species.	daidzin	152-159	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	32-35
15377279-7	2005	However, since co-incubation of sGC with purified ALDH2 led to significant stimulation of cGMP formation by GTN that was completely inhibited by 0.1 mM daidzin and NO scavengers, ALDH2 may convert GTN directly into NO or a related species.	daidzin	152-159	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	50-55
15377279-7	2005	However, since co-incubation of sGC with purified ALDH2 led to significant stimulation of cGMP formation by GTN that was completely inhibited by 0.1 mM daidzin and NO scavengers, ALDH2 may convert GTN directly into NO or a related species.	daidzin	152-159	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	179-184
15276617-8	2004	The phytoestrogens coumestrol, genistein, genistin, daidzein, daidzin and naringenin were relatively more potent with ERbeta.	daidzin	62-69	estrogen receptor 2	Homo sapiens	118-124
12939789-4	2003	Daidzin analogs that potently inhibit ALDH-2 but not MAO are the most anti-dipsotropic, whereas those that also inhibit MAO are not.	daidzin	0-7	aldehyde dehydrogenase 2 family member	Homo sapiens	38-44
12939789-5	2003	On the basis of these findings, it was proposed that the liver mitochondrial MAO-ALDH-2 pathway is the primary site of action of daidzin and that a biogenic aldehyde derived from the action of MAO mediates its anti-dipsotropic action.	daidzin	129-136	aldehyde dehydrogenase 2 family member	Homo sapiens	81-87
12927869-2	2003	Correlation studies using structural analogues of daidzin suggests that it acts by raising the monoamine oxidase (MAO)/mitochondrial aldehyde dehydrogenase (ALDH-2) activity ratio (J. Med.	daidzin	50-57	aldehyde dehydrogenase 2 family member	Homo sapiens	157-163
10597900-2	1999	We found that the isoflavones genistin and daidzin, and their respective aglucone forms daidzein and genistein, block 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin)-induced CYP1A1 enzyme activity.	daidzin	43-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	177-183
19003112-0	2002	Phytoestrogens genistein and daidzin enhance the acetylcholinesterase activity of the rat pheochromocytoma cell line PC12 by binding to the estrogen receptor.	daidzin	29-36	acetylcholinesterase	Rattus norvegicus	49-69
19003112-0	2002	Phytoestrogens genistein and daidzin enhance the acetylcholinesterase activity of the rat pheochromocytoma cell line PC12 by binding to the estrogen receptor.	daidzin	29-36	estrogen receptor 1	Rattus norvegicus	140-157
12016029-1	2002	Daidzin, a soy-derived biologically active natural product, has been reported to inhibit mitochondrial aldehyde dehydrogenase and suppress ethanol intake.	daidzin	0-7	aldehyde dehydrogenase 2 family member	Rattus norvegicus	89-125
11563931-2	2001	Further, we have identified the monoamine oxidase (MAO)-aldehyde dehydrogenase (ALDH-2) pathway of the mitochondria as the potential site of action of daidzin.	daidzin	151-158	aldehyde dehydrogenase 2 family member	Homo sapiens	80-86
11563931-3	2001	Daidzin analogues that potently inhibit ALDH-2 but have no or little effect on MAO are most antidipsotropic, whereas those that also inhibit MAO exhibit little, if any, antidipsotropic activity.	daidzin	0-7	aldehyde dehydrogenase 2 family member	Homo sapiens	40-46
11306106-6	2001	Correlation studies using structural analogs of daidzin led to the hypothesis that the mitochondrial MAO/ALDH-2 pathway may be the site of action of daidzin and that one or more biogenic aldehydes such as 5-hydroxyindole-3-acetaldehyde (5-HIAL) and/or DOPAL derived from the action of monoamine oxidase (MAO) may be mediators of its antidipsotropic action.	daidzin	48-55	monoamine oxidase A	Rattus norvegicus	101-104
11306106-6	2001	Correlation studies using structural analogs of daidzin led to the hypothesis that the mitochondrial MAO/ALDH-2 pathway may be the site of action of daidzin and that one or more biogenic aldehydes such as 5-hydroxyindole-3-acetaldehyde (5-HIAL) and/or DOPAL derived from the action of monoamine oxidase (MAO) may be mediators of its antidipsotropic action.	daidzin	48-55	aldehyde dehydrogenase 2 family member	Rattus norvegicus	105-111
11306106-6	2001	Correlation studies using structural analogs of daidzin led to the hypothesis that the mitochondrial MAO/ALDH-2 pathway may be the site of action of daidzin and that one or more biogenic aldehydes such as 5-hydroxyindole-3-acetaldehyde (5-HIAL) and/or DOPAL derived from the action of monoamine oxidase (MAO) may be mediators of its antidipsotropic action.	daidzin	48-55	monoamine oxidase A	Rattus norvegicus	285-302
11306106-6	2001	Correlation studies using structural analogs of daidzin led to the hypothesis that the mitochondrial MAO/ALDH-2 pathway may be the site of action of daidzin and that one or more biogenic aldehydes such as 5-hydroxyindole-3-acetaldehyde (5-HIAL) and/or DOPAL derived from the action of monoamine oxidase (MAO) may be mediators of its antidipsotropic action.	daidzin	48-55	monoamine oxidase A	Rattus norvegicus	304-307
11306106-6	2001	Correlation studies using structural analogs of daidzin led to the hypothesis that the mitochondrial MAO/ALDH-2 pathway may be the site of action of daidzin and that one or more biogenic aldehydes such as 5-hydroxyindole-3-acetaldehyde (5-HIAL) and/or DOPAL derived from the action of monoamine oxidase (MAO) may be mediators of its antidipsotropic action.	daidzin	149-156	monoamine oxidase A	Rattus norvegicus	101-104
11306106-6	2001	Correlation studies using structural analogs of daidzin led to the hypothesis that the mitochondrial MAO/ALDH-2 pathway may be the site of action of daidzin and that one or more biogenic aldehydes such as 5-hydroxyindole-3-acetaldehyde (5-HIAL) and/or DOPAL derived from the action of monoamine oxidase (MAO) may be mediators of its antidipsotropic action.	daidzin	149-156	aldehyde dehydrogenase 2 family member	Rattus norvegicus	105-111
11306106-0	2001	Biogenic aldehyde(s) derived from the action of monoamine oxidase may mediate the antidipsotropic effect of daidzin.	daidzin	108-115	monoamine oxidase A	Rattus norvegicus	48-65
11306106-3	2001	In vitro, daidzin is a potent and selective inhibitor of mitochondrial aldehyde dehydrogenase (ALDH-2).	daidzin	10-17	aldehyde dehydrogenase 2 family member	Rattus norvegicus	57-93
11306106-3	2001	In vitro, daidzin is a potent and selective inhibitor of mitochondrial aldehyde dehydrogenase (ALDH-2).	daidzin	10-17	aldehyde dehydrogenase 2 family member	Rattus norvegicus	95-101
11306106-5	2001	Using isolated hamster liver mitochondria and 5-hydroxytryptamine (5-HT) and dopamine (DA) as the substrates, we demonstrated that daidzin inhibits the second but not the first step of the MAO/ALDH-2 pathway, the major pathway that catalyzes monoamine metabolism in mitochondria.	daidzin	131-138	monoamine oxidase A	Rattus norvegicus	189-192
11306106-5	2001	Using isolated hamster liver mitochondria and 5-hydroxytryptamine (5-HT) and dopamine (DA) as the substrates, we demonstrated that daidzin inhibits the second but not the first step of the MAO/ALDH-2 pathway, the major pathway that catalyzes monoamine metabolism in mitochondria.	daidzin	131-138	aldehyde dehydrogenase 2 family member	Rattus norvegicus	193-199
9050837-3	1997	Daidzin is also a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase (ALDH-2).	daidzin	0-7	aldehyde dehydrogenase 2 family member	Homo sapiens	96-102
9050837-10	1997	We postulate that a physiological pathway catalyzed by ALDH-2, so far undefined, controls ethanol intake of golden hamsters and mediates the antidipsotropic effect of daidzin.	daidzin	167-174	aldehyde dehydrogenase, mitochondrial	Mesocricetus auratus	55-61
8032168-7	1994	In vitro, daidzin and daidzein inhibited human mitochondrial aldehyde dehydrogenase (ALDH-2) and gamma gamma-alcohol dehydrogenase (gamma gamma-ADH), respectively.	daidzin	10-17	aldehyde dehydrogenase 2 family member	Homo sapiens	85-91
8032168-9	1994	These findings clearly distinguish the action(s) of daidzin and daidzein from those of the classic, broad acting inhibitors of ALDH (e.g. disulfiram) and class I ADH isozymes (e.g. 4-methylpyrazole), and identify them as a new class of compounds that offer promise as safe and effective therapeutic agents for alcohol abuse.	daidzin	52-59	aldehyde dehydrogenase 2 family member	Homo sapiens	127-131