PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33810476-2 2021 The latter were prepared by Rh2(oct)4 catalyzed reaction of 2-(3-aryl/heteroaryl)-2-diazoacetyl-2H-azirines with a set of substituted acetonitriles, benzonitriles, acrylonitrile and fumaronitrile. benzonitrile 149-162 Rh associated glycoprotein Homo sapiens 28-31 33444019-0 2021 Reactivity Trends in the Gas-Phase Addition of Acetylene to the N-Protonated Aryl Radical Cations of Pyridine, Aniline, and Benzonitrile. benzonitrile 124-136 gastrin Homo sapiens 25-28 34792329-4 2021 Especially, under the industrially relevant current (~250 mA), the Ni3N catalyst remains ~95% selective for benzonitrile production, reaching 1.43 mmol h-1 cm-2. benzonitrile 108-120 H1.5 linker histone, cluster member Homo sapiens 152-160 33862074-5 2021 Catalytic behavior of Pd NPs/CS/Co3O4 was investigated in the production of different substituted benzonitriles via aryl halide cyanation. benzonitrile 98-111 citrate synthase Homo sapiens 29-31 34633126-5 2022 Time-resolved transient absorption measurements on the ns-time scale shows that the addition of C 60 to NG-1 solutions and photo-exciting them at 460 nm lead to the solvent-dependent formation of new species, in particular the formation of one-electron reduced form of C 60 in benzonitrile is observed. benzonitrile 279-291 interleukin 19 Homo sapiens 105-109 34032448-1 2021 A striking dependence on the method of workup has been found for annulation of benzonitriles ArC N to N-methyl 2-toluamide (1), facilitated by n-BuLi (2 equiv): quenching the reaction by a slow addition of water produced the expected 1-isoquinolones 2; by contrast, slow pouring of the reaction mixture into water afforded the cyclic aminals 5 (retaining the NMe group of the original toluamide). benzonitrile 79-92 activity regulated cytoskeleton associated protein Homo sapiens 93-96 33749264-5 2021 The recent astronomical detection of cyanobenzene, the simplest aromatic nitrile, in the dark molecular cloud TMC-1, and soon afterward in additional prestellar and possibly protostellar sources, establishes that aromatic chemistry is likely widespread in the earliest stages of star formation. benzonitrile 37-49 transmembrane channel like 1 Homo sapiens 110-115 33872029-4 2021 Subsequent femtosecond transient absorption studies along with global target analysis, performed in both polar and nonpolar solvents, confirmed such processes in which the CS was efficient in asymmetric 2, having both TCBD and DCNQ acceptors in polar benzonitrile, while in toluene, only CT was witnessed. benzonitrile 251-263 citrate synthase Homo sapiens 172-174 31676812-3 2019 Here we show that quasi atomic-dispersion of Pd within the outermost layer of Ni nanoparticles to form a Pd1Ni single-atom surface alloy structure maximizes the Pd utilization and breaks the strong metal-selectivity relations in benzonitrile hydrogenation, by prompting the yield of dibenzylamine drastically from ~5 to 97% under mild conditions (80 C; 0.6 MPa), and boosting an activity to about eight and four times higher than Pd and Pt standard catalysts, respectively. benzonitrile 229-241 programmed cell death 1 Homo sapiens 105-108 32960597-4 2020 To address the issue, we synthesized a series of dyads with properties switching between electron and energy transfer in both polar (benzonitrile) and non-polar (toluene) media, and developed a computation procedure with sufficient reliability by which we can predict the CS properties of the dyad in different media and design new dyads. benzonitrile 133-145 citrate synthase Homo sapiens 272-274 32266641-0 2020 Ruthenium(II)/Benzonitrile Complex Induces Cytotoxic Effect in Sarcoma-180 Cells by Caspase-Mediated and Tp53/p21-Mediated Apoptosis, with Moderate Brine Shrimp Toxicity. benzonitrile 14-26 transformation related protein 53 Mus musculus 105-109 32266641-0 2020 Ruthenium(II)/Benzonitrile Complex Induces Cytotoxic Effect in Sarcoma-180 Cells by Caspase-Mediated and Tp53/p21-Mediated Apoptosis, with Moderate Brine Shrimp Toxicity. benzonitrile 14-26 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 110-113 30786170-3 2019 A similar catalytic system also allowed methylation with Me3 Al at 70 C. The pivaloyl imine of the product could be readily converted to a cyano group, thus allowing convenient preparation of ortho-functionalized benzonitriles. benzonitrile 214-227 malic enzyme 3 Homo sapiens 57-60 31148251-4 2019 When the solvent was replaced by benzonitrile, the product MMA was successfully purified by distillation. benzonitrile 33-45 monocyte to macrophage differentiation associated Homo sapiens 59-62 28841462-0 2017 A theoretical survey of substituent effects on the properties of pnicogen and hydrogen bonds in cationic complexes of PH4+ with substituted benzonitrile. benzonitrile 140-152 prolyl 4-hydroxylase, transmembrane Homo sapiens 118-121 30681095-1 2019 The recent astronomical detection of benzonitrile (C6H5CN) in the cold, starless cloud TMC-1 demonstrates that aromatic chemistry is efficient even in the primordial stages of star and planet formation. benzonitrile 37-49 transmembrane channel like 1 Homo sapiens 87-92 30681095-1 2019 The recent astronomical detection of benzonitrile (C6H5CN) in the cold, starless cloud TMC-1 demonstrates that aromatic chemistry is efficient even in the primordial stages of star and planet formation. benzonitrile 51-57 transmembrane channel like 1 Homo sapiens 87-92 29630840-1 2018 The use of Pd(DPEPhos)Cl2 (P26) as a catalyst for the formation of benzonitriles and their heterocyclic analogues provides excellent complementarity to existing catalysts, allowing highly electron-deficient heterocyclic aryl halides to be efficiently converted to the corresponding nitriles using K4[Fe(CN)6]) as cyanide source. benzonitrile 67-80 transmembrane p24 trafficking protein 3 Homo sapiens 27-30 29326270-4 2018 We observed hyperfine-resolved transitions of benzonitrile in emission from the molecular cloud TMC-1. benzonitrile 46-58 transmembrane channel like 1 Homo sapiens 96-101 29568458-10 2017 These experiments suggest the possibility of a catalytic cycle involving initially the formation of two Pd(ii)-species from the oxidative addition of L n Pd(0) into HCN and an aryl bromide followed by a transmetallation step to L n Pd(Ar)(CN) and L n Pd(H)(Br), which both reductively eliminate, the latter in the presence of KOAc, to generate the benzonitrile and L n Pd(0). benzonitrile 348-360 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 165-168 28008970-4 2016 Here, TERS in combination with atomic force microscopy (AFM), and conventional Raman spectroscopy characterizes insulin assemblies generated during inhibition and dissection experiments in the presence of benzonitrile, dimethylsulfoxide, quercetin, and beta-carotene. benzonitrile 205-217 insulin Homo sapiens 112-119 28776992-6 2017 Although aniline and pyridine derivatives interact with His342, benzonitriles conferred the best rat and human nNOS inhibition. benzonitrile 64-77 nitric oxide synthase 1 Homo sapiens 111-115 31457582-1 2017 The homogeneous transfer hydrogenation of benzonitrile with 2-propanol or 1,4-butanediol produced N-benzylidene benzylamine (BBA, 85% yield) using 5 mol % [Ni(COD)2] as a catalytic precursor and a mixture of Cy2P(CH2)2PCy2 and Cy2P(CH2)2P(O)Cy2 as ancillary ligands, under mild reaction conditions (120 C, 96 h, tetrahydrofuran). benzonitrile 42-54 COD2 Homo sapiens 159-164 26663213-1 2016 Enzymatic dioxygenation of benzyl azide by toluene dioxygenase (TDO) produces significant amounts of the cis-cyclohexadienediol derived from benzonitrile, along with the expected azido diols. benzonitrile 141-153 tryptophan 2,3-dioxygenase Homo sapiens 64-67 26663213-2 2016 We demonstrate that TDO catalyses the oxidation of benzyl azide to benzonitrile, which is further dioxygenated to produce the observed cis-diol. benzonitrile 67-79 tryptophan 2,3-dioxygenase Homo sapiens 20-23 24187982-6 2013 The reversibility of the activation of the nitriles in the resulting ketimido compounds was demonstrated by the displacement of p-CF3-benzonitrile from cis-[Re(PNP(tBu)-N CPh(pCF3))(CO)2] (6) upon addition of an excess of benzonitrile and by the temperature-dependent [1,3]-addition of pivalonitrile to complex 4. benzonitrile 134-146 purine nucleoside phosphorylase Homo sapiens 160-163 26369917-1 2015 Quantum chemical calculations have been performed to study the interplay between halogen bond and lithium bond in the ternary systems FX-C6H5CN-LiF, FLi-C6H5CN-XF, and FLi-C6H5X-NH3 (X = Cl, Br, and I) involving aromatic compounds. benzonitrile 137-143 LIF interleukin 6 family cytokine Homo sapiens 144-147 26120733-2 2015 Introduction of an N-methylethane-1,2-diamine side chain and conformational constraints such as benzonitrile and pyridine as the middle aromatic linker were sufficient to increase human and rat nNOS binding affinity and inducible and endothelial NOS selectivity. benzonitrile 96-108 nitric oxide synthase 1 Rattus norvegicus 194-198 26124897-0 2015 Synthesis and characterization of the cyanobenzene-ethylenedithio-TTF donor. benzonitrile 38-50 ras homolog family member H Homo sapiens 66-69 24291433-3 2014 Both UV-Vis and steady state measurements elicit almost similar magnitude of binding constant for the PyC60/1 complex in toluene and benzonitrile, viz., 6825 and 6540 dm(3 )mol(-1), respectively. benzonitrile 133-145 pyrin domain containing 1 Homo sapiens 102-109 19711975-7 2009 DFT calculations on simple single-molecule complexes with benzonitrile are consistent with the presence of pi-H bonds to the nitrile group as a possible source of the F band dependence on alpha. benzonitrile 58-70 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 107-111 23150124-1 2013 With the use of benzonitrile-stabilized Au(I) catalyst [Au(IPr)(NCPh)]SbF(6) (Ic; IPr=1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), a spectrum of reactivity is observed for propargyl ester 4a with cyclic vinyl ethers, ranging from exclusively [3C+2C] cycloaddition reactions to exclusively cyclopropanation depending only on the structure of the substrate. benzonitrile 16-28 SP110 nuclear body protein Homo sapiens 82-87 22100142-8 2012 Examination of a homologs series of benzonitriles established that the phthalonitrile moiety is more optimal for MAO-B inhibition than the corresponding benzonitrile moiety, and that C3-substituted benzonitriles are better MAO-B inhibitors than C4-substituted benzonitriles. benzonitrile 36-49 monoamine oxidase B Homo sapiens 113-118 22100142-8 2012 Examination of a homologs series of benzonitriles established that the phthalonitrile moiety is more optimal for MAO-B inhibition than the corresponding benzonitrile moiety, and that C3-substituted benzonitriles are better MAO-B inhibitors than C4-substituted benzonitriles. benzonitrile 36-48 monoamine oxidase B Homo sapiens 113-118 22100142-8 2012 Examination of a homologs series of benzonitriles established that the phthalonitrile moiety is more optimal for MAO-B inhibition than the corresponding benzonitrile moiety, and that C3-substituted benzonitriles are better MAO-B inhibitors than C4-substituted benzonitriles. benzonitrile 198-211 monoamine oxidase B Homo sapiens 223-228 22100142-8 2012 Examination of a homologs series of benzonitriles established that the phthalonitrile moiety is more optimal for MAO-B inhibition than the corresponding benzonitrile moiety, and that C3-substituted benzonitriles are better MAO-B inhibitors than C4-substituted benzonitriles. benzonitrile 198-211 monoamine oxidase B Homo sapiens 223-228 21899930-4 2011 Analysis of the possible binding interactions of these inhibitors with active site models of human MAO-A and -B led to the design of phenolic and benzonitrile derivatives of 2c and 2d. benzonitrile 146-158 monoamine oxidase A Homo sapiens 99-111 15616693-2 2005 The first compound bearing a single thiophene ring (PT1) is used as model and shows a behavior similar to P, studied previously, while in the compound with two thiophene rings attached (PT2) electron transfer from the thiophene donor to the peryleneimide acceptor is observed in benzonitrile. benzonitrile 279-291 zinc finger protein 77 Homo sapiens 52-55 18335923-5 2008 Compared with the SubPc-TPA dyad, a long-lived charge-separated state was observed for the SubPc-TPA-C(60) triad with the lifetime of the radical ion pairs (tau(RIP)) of 670 ns in benzonitrile. benzonitrile 180-192 receptor interacting serine/threonine kinase 1 Homo sapiens 161-164 18335923-6 2008 Interestingly, further charge stabilization was achieved in the charge-separated state of SubPc-TPA-(C(60))(2), in which the tau(RIP) was found to be 1050 ns in benzonitrile. benzonitrile 161-173 receptor interacting serine/threonine kinase 1 Homo sapiens 129-132 18666761-3 2008 For the compound with n = 4 (DBA4), analysis of dipole signals indicates that the effective charge separation distances in toluene, 1,4-dioxane, ethyl acetate, tetrahydrofuran, dichloromethane, 1,2-dichloroethane, 2-methylpentanone-3, 3-pentanone, and benzonitrile are 2.2, 2.5, 4.5, 4.7, 5.5, 5.5, 4.8, and 6.3 A, respectively. benzonitrile 252-264 ribosomal protein S17 Homo sapiens 29-33 17136283-4 2006 In CH(2)Cl(2) and benzonitrile, the PhN(nBu)(2) terminated hybrids undergo electron transfer with charge separation lasting as long as 390 ns in the more polar medium, as detected via near-infrared transient absorption spectroscopy. benzonitrile 18-30 carbamoyl-phosphate synthase 1 Homo sapiens 36-39 15315452-4 2004 Compared to the Co complexes 9, Co4, and Co1, the first oxidation of Co3 is considerably shifted to more positive potentials, if benzonitrile instead of dichloromethane is used as solvent. benzonitrile 129-141 complement C4A (Rodgers blood group) Homo sapiens 32-35