PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32369673-8	2020	Furthermore, this MOF-PTU hybrid material was utilized as a spray coating onto Nyco textile fibers and displayed excellent adhesion to the fiber surface.	ptu	22-25	lysine acetyltransferase 8	Homo sapiens	18-21
2232704-8	1990	After discontinuation of PTU treatment, a rapid increase in size, number and GH labeling of secretory granules and simultaneous involution of distended rough endoplasmic reticulum with reduction of thyrotropin labeling took place in thyrosomatotrophs.	ptu	25-28	gonadotropin releasing hormone receptor	Rattus norvegicus	77-79
2318160-11	1990	Hypothyroidism induced by PTU, on the other hand, was able to delay the developmental rise in liver apo A-IV mRNA.	ptu	26-29	apolipoprotein A4	Rattus norvegicus	100-108
34389322-0	2021	PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling.	ptu	0-3	Wnt family member 5A	Homo sapiens	98-103
34389322-7	2021	The principal finding was that PTU impaired the formation of actin protrusions by decreasing the secretion of Wnt5a, which dysregulated the Wnt/planar cell polarity (PCP) pathway and actin cytoskeletal dynamics.	ptu	31-34	wingless-type MMTV integration site family, member 5A	Mus musculus	110-115
34389322-7	2021	The principal finding was that PTU impaired the formation of actin protrusions by decreasing the secretion of Wnt5a, which dysregulated the Wnt/planar cell polarity (PCP) pathway and actin cytoskeletal dynamics.	ptu	31-34	Wnt family member 5A	Homo sapiens	140-143
34389322-8	2021	Exogenous Wnt5a restored invasion and Wnt/PCP signalling in PTU-treated cells.	ptu	60-63	wingless-type MMTV integration site family, member 5A	Mus musculus	10-15
34389322-8	2021	Exogenous Wnt5a restored invasion and Wnt/PCP signalling in PTU-treated cells.	ptu	60-63	Wnt family member 5A	Homo sapiens	38-41
34389322-9	2021	PTU is the prototype of a novel class of agents that selectively dysregulate the Wnt/PCP pathway by inhibiting Wnt5a secretion and actin dynamics to impair MDA-MB-231 cell migration and invasion.	ptu	0-3	Wnt family member 5A	Homo sapiens	81-84
34389322-9	2021	PTU is the prototype of a novel class of agents that selectively dysregulate the Wnt/PCP pathway by inhibiting Wnt5a secretion and actin dynamics to impair MDA-MB-231 cell migration and invasion.	ptu	0-3	Wnt family member 5A	Homo sapiens	111-116
1173484-1	1975	Radioactivity was found bound to follicular thyroglobulin after administration of 35-S-propylthiouracil (PTU) to rats.	ptu	105-108	thyroglobulin	Rattus norvegicus	44-57
1173484-7	1975	The highest S/Tg ratio 1.10 was noted at 19S thyroglobulin, 17 h after a single injection of PTU.	ptu	93-96	thyroglobulin	Rattus norvegicus	45-58
33509031-9	2021	Besides, the dynamic tests of PTU F1 showed that the TtF in the experimental group was significantly higher than that in the dynamic control group.	ptu	30-33	ras homolog family member H	Homo sapiens	53-56
31239322-8	2019	While VEGFR1 expression in pTU patients did not predict prognosis; high percentage of VEGFR1+ cells in liver metastasis was associated with worse patient outcome.	ptu	27-30	fms related receptor tyrosine kinase 1	Homo sapiens	6-12
19397998-5	2009	At the adult stage, the distribution variability of hippocampal CA1 pyramidal neurons reflecting mismigration could be detected in animals receiving both thyrotoxins, with a dose-dependent effect by PTU.	ptu	199-202	carbonic anhydrase 1	Rattus norvegicus	64-67
22583692-7	2012	Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-gamma, IL-8, MIG and IP-10.	ptu	85-88	interferon gamma	Homo sapiens	108-117
22583692-7	2012	Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-gamma, IL-8, MIG and IP-10.	ptu	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
20833952-11	2010	Histone H3K9me was enriched in chromatin of both the intergenic and alpha-MHC promoters in the PTU group, whereas histone H4K20me1 was enriched in chromatin of beta-MHC promoter in the normal control and T(3) groups.	ptu	95-98	myosin heavy chain 7	Rattus norvegicus	74-77
31068541-5	2019	PTU-exposure decreased DCX+ and NeuN+ granule cell lineage subpopulations, synaptic plasticity-related FOS+ granule cells, and hilar PVALB+ and GAD67+ GABAergic interneurons, increased hilar SST+ and CALB2+ interneurons, and upregulated Gria3, Otx2, and antioxidant enzyme genes in the dentate gyrus on PND 77.	ptu	0-3	doublecortin	Rattus norvegicus	23-26
31068541-5	2019	PTU-exposure decreased DCX+ and NeuN+ granule cell lineage subpopulations, synaptic plasticity-related FOS+ granule cells, and hilar PVALB+ and GAD67+ GABAergic interneurons, increased hilar SST+ and CALB2+ interneurons, and upregulated Gria3, Otx2, and antioxidant enzyme genes in the dentate gyrus on PND 77.	ptu	0-3	RNA binding fox-1 homolog 3	Rattus norvegicus	32-36
31068541-5	2019	PTU-exposure decreased DCX+ and NeuN+ granule cell lineage subpopulations, synaptic plasticity-related FOS+ granule cells, and hilar PVALB+ and GAD67+ GABAergic interneurons, increased hilar SST+ and CALB2+ interneurons, and upregulated Gria3, Otx2, and antioxidant enzyme genes in the dentate gyrus on PND 77.	ptu	0-3	glutamate decarboxylase 1	Rattus norvegicus	144-149
31068541-5	2019	PTU-exposure decreased DCX+ and NeuN+ granule cell lineage subpopulations, synaptic plasticity-related FOS+ granule cells, and hilar PVALB+ and GAD67+ GABAergic interneurons, increased hilar SST+ and CALB2+ interneurons, and upregulated Gria3, Otx2, and antioxidant enzyme genes in the dentate gyrus on PND 77.	ptu	0-3	calbindin 2	Rattus norvegicus	200-205
31068541-5	2019	PTU-exposure decreased DCX+ and NeuN+ granule cell lineage subpopulations, synaptic plasticity-related FOS+ granule cells, and hilar PVALB+ and GAD67+ GABAergic interneurons, increased hilar SST+ and CALB2+ interneurons, and upregulated Gria3, Otx2, and antioxidant enzyme genes in the dentate gyrus on PND 77.	ptu	0-3	glutamate ionotropic receptor AMPA type subunit 3	Rattus norvegicus	237-242
31068541-5	2019	PTU-exposure decreased DCX+ and NeuN+ granule cell lineage subpopulations, synaptic plasticity-related FOS+ granule cells, and hilar PVALB+ and GAD67+ GABAergic interneurons, increased hilar SST+ and CALB2+ interneurons, and upregulated Gria3, Otx2, and antioxidant enzyme genes in the dentate gyrus on PND 77.	ptu	0-3	orthodenticle homeobox 2	Rattus norvegicus	244-248
22583692-7	2012	Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-gamma, IL-8, MIG and IP-10.	ptu	85-88	C-X-C motif chemokine ligand 9	Homo sapiens	125-128
22583692-7	2012	Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-gamma, IL-8, MIG and IP-10.	ptu	85-88	C-X-C motif chemokine ligand 10	Homo sapiens	133-138
15700765-0	2004	Retinoic acid reverses the PTU related decrease in neurogranin level in mice brain.	ptu	27-30	neurogranin	Mus musculus	51-62
16947002-4	2006	Immunohistochemistry showed an increased number of proliferating cell nuclear antigen (PCNA)-positive cells in the thyroid gland of PTU-treated rats.	ptu	132-135	proliferating cell nuclear antigen	Rattus norvegicus	51-85
16947002-4	2006	Immunohistochemistry showed an increased number of proliferating cell nuclear antigen (PCNA)-positive cells in the thyroid gland of PTU-treated rats.	ptu	132-135	proliferating cell nuclear antigen	Rattus norvegicus	87-91
17940896-3	2008	In contrast, 6-n-propyl-2-thyouracil (PTU) decreased nNOS activity and nNOS level to 45 +/- 10% and to 19 +/- 4%, respectively.	ptu	38-41	nitric oxide synthase 1	Rattus norvegicus	53-57
17940896-3	2008	In contrast, 6-n-propyl-2-thyouracil (PTU) decreased nNOS activity and nNOS level to 45 +/- 10% and to 19 +/- 4%, respectively.	ptu	38-41	nitric oxide synthase 1	Rattus norvegicus	71-75
17036403-4	2006	The high incidence of liver toxicity related to PTU, its potential severity and delayed occurrence after initiation of treatment are in favor of monthly alanine aminotransferase monitoring, at least during the first six months of therapy.	ptu	48-51	glutamic--pyruvic transaminase	Homo sapiens	153-177
15700765-6	2004	A quantitative evaluation of RA nuclear receptors (RAR, RXR), T3 nuclear receptor (TR) and of neurogranin (RC3, a RA target gene which codes for a protein considered as a good marker of synaptic plasticity) in PTU treated mice injected with vehicle or RA or T3 was carried out.	ptu	210-213	retinoic acid receptor, alpha	Mus musculus	29-49
15700765-6	2004	A quantitative evaluation of RA nuclear receptors (RAR, RXR), T3 nuclear receptor (TR) and of neurogranin (RC3, a RA target gene which codes for a protein considered as a good marker of synaptic plasticity) in PTU treated mice injected with vehicle or RA or T3 was carried out.	ptu	210-213	neurogranin	Mus musculus	94-105
15700765-6	2004	A quantitative evaluation of RA nuclear receptors (RAR, RXR), T3 nuclear receptor (TR) and of neurogranin (RC3, a RA target gene which codes for a protein considered as a good marker of synaptic plasticity) in PTU treated mice injected with vehicle or RA or T3 was carried out.	ptu	210-213	neurogranin	Mus musculus	107-110
11763065-2	2001	The results of the voltammetric measurements showed that the presence of both PTU and Co(II) gives rise to a new irreversible peak at about -1.5 V. Based upon our previous results obtained in the study of other sulfur compounds and the sulfide ion itself, the peak was ascribed to the catalytic hydrogen evolution superimposed on the reduction of the coordinated Co(II) ion.	ptu	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	363-369
9535813-6	1998	Interestingly, upregulation of Kv1.4 mRNA expression and downregulation of Kv1.5 mRNA expression were concomitantly induced in the ventricle by the PTU-treatment.	ptu	148-151	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	31-36
11582667-2	2001	Catalase activity was decreased in sluggish PTU and increased in exacerbation, which is attributed to decompensation of the antioxidant system and its effect on the course of posttraumatic inflammation.	ptu	44-47	catalase	Homo sapiens	0-8
9535813-6	1998	Interestingly, upregulation of Kv1.4 mRNA expression and downregulation of Kv1.5 mRNA expression were concomitantly induced in the ventricle by the PTU-treatment.	ptu	148-151	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	75-80
8964848-4	1996	The phenolic ring deiodination pathway corresponded to the type II 5"-deiodinase isoenzyme with regard to its high affinity for T4 and rT3 (Km = 2.2 and 2.4 nmol/L, respectively), its insensitivity to 6-propyl-n-2-thiouracil (PTU), and the sequential reaction mechanism.	ptu	226-229	iodothyronine deiodinase 2	Homo sapiens	59-80
7600766-7	1995	Results of the hyperglycemic clamp experiment indicated that the mean plasma insulin increment and the ratio of mean plasma insulin increment to glucose infusion rate were significantly higher (P < 0.01) in high PTU-treated sheep than in low PTU-treated and control sheep.	ptu	215-218	LOC105613195	Ovis aries	77-84
7600766-7	1995	Results of the hyperglycemic clamp experiment indicated that the mean plasma insulin increment and the ratio of mean plasma insulin increment to glucose infusion rate were significantly higher (P < 0.01) in high PTU-treated sheep than in low PTU-treated and control sheep.	ptu	215-218	LOC105613195	Ovis aries	124-131
7600766-11	1995	The response areas of plasma thyroxine and triiodothyronine to thyrotropin-releasing hormone injection were blunted (P < 0.01) in PTU-treated sheep compared with those of control sheep.	ptu	133-136	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	63-92
7600766-12	1995	The high PTU treatment induced low thyroid function, enhanced insulin secretion response, and impaired insulin action in sheep.	ptu	9-12	LOC105613195	Ovis aries	62-69
8277507-9	1993	5-(Phenylselenenyl)uracil (PSU, 6) and 5-(phenylthio)uracil (PTU, 7) inhibited DHUDase with apparent K(i) values of 4.8 and 5.4 microM, respectively.	ptu	61-64	dihydropyrimidine dehydrogenase	Homo sapiens	79-86