PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2572173-6	1989	Phaclofen, a GABAB antagonist, prevented the inhibitory effects of somatostatin.	gabab	13-18	somatostatin	Cavia porcellus	67-79
2855213-1	1988	The augmentation of isoproterenol or vasoactive intestinal peptide (VIP)-stimulated cyclic AMP accumulation in rat brain slices by the GABAB agonist baclofen was compared to that mediated by tumor-promoting phorbol esters.	gabab	135-140	vasoactive intestinal peptide	Rattus norvegicus	37-66
2855213-1	1988	The augmentation of isoproterenol or vasoactive intestinal peptide (VIP)-stimulated cyclic AMP accumulation in rat brain slices by the GABAB agonist baclofen was compared to that mediated by tumor-promoting phorbol esters.	gabab	135-140	vasoactive intestinal peptide	Rattus norvegicus	68-71
3026578-9	1986	Administration of baclofen, a specific GABAB agonist (10(-7) to 10(-4) M) induced a dose-dependent inhibition of alpha-MSH secretion.	gabab	39-44	proopiomelanocortin	Homo sapiens	113-122
32755589-5	2020	RGS6 overexpression mimics the positive effects of voluntary running on morphological and physiological maturation of adult new neurons and reduced sensitivity of adult-born neurons to the inhibitory effect of GABAB (gamma-Aminobutyric acid B) receptor activation.	gabab	210-215	regulator of G protein signaling 6	Homo sapiens	0-4
6322803-8	1984	We speculate that the stimulus for the increased number of GABAA and GABAB binding sites is a reduction in GABA release subsequent to a reduction in GAD activity.	gabab	69-74	glutamate-ammonia ligase	Rattus norvegicus	149-152
2874192-3	1986	The enhancement of isoproterenol-stimulated cAMP production by alpha-adrenergic and gamma-aminobutyric acid-B (GABAB) agonists was reduced by exposing the tissue to EGTA, a chelator of divalent cations, or quinacrine, a nonselective inhibitor of phospholipase A2.	gabab	111-116	phospholipase A2 group IB	Rattus norvegicus	246-262
3010078-3	1986	Employing this technique, we found that the GABAA agonists, muscimol, isoguvacine, 4,5,6,7-tetrahydroisoxazolo(5,4-C)pyridine-3-ol, and 3-amino-1-propane sulfonate, all produced a concentration-dependent increase in 36Cl- influx, but baclofen, a GABAB agonist, failed to alter 36Cl- flux.	gabab	246-251	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	44-49
33115988-10	2021	Our data suggested PHF24 is expressed in the inhibitory interneurons and may play important roles in modulation of the GABAB signaling.	gabab	119-124	PHD finger protein 24	Rattus norvegicus	19-24
33359928-13	2021	Abnormal SP shortening and lack of MEP depression concur with a reduction in post-exhaustion corticomotor inhibition, suggesting a possible GABAB-ergic dysfunction.	gabab	140-145	solute carrier family 35 member G1	Homo sapiens	77-81
32765223-4	2020	We demonstrate that fibulin-2 hampers GABAB activation, presumably through decreasing agonist-induced conformational changes.	gabab	38-43	fibulin 2	Rattus norvegicus	20-29
32765223-5	2020	Fibulin-2 regulates the GABAB-mediated presynaptic inhibition of neurotransmitter release and weakens the GABAB-mediated inhibitory effect in neuronal cell culture.	gabab	24-29	fibulin 2	Rattus norvegicus	0-9
32765223-5	2020	Fibulin-2 regulates the GABAB-mediated presynaptic inhibition of neurotransmitter release and weakens the GABAB-mediated inhibitory effect in neuronal cell culture.	gabab	106-111	fibulin 2	Rattus norvegicus	0-9
32765223-8	2020	By applying anti-fibulin-2 siRNA in vivo, we enhanced the antinociceptive effect of intrathecal baclofen in neuropathic rats, thus demonstrating that fibulin-2 limits the action of GABAB agonists in vivo.	gabab	181-186	fibulin 2	Rattus norvegicus	17-26
32765223-8	2020	By applying anti-fibulin-2 siRNA in vivo, we enhanced the antinociceptive effect of intrathecal baclofen in neuropathic rats, thus demonstrating that fibulin-2 limits the action of GABAB agonists in vivo.	gabab	181-186	fibulin 2	Rattus norvegicus	150-159
30592096-0	2019	Dexmedetomidine protects rats from postoperative cognitive dysfunction via regulating the GABAB R-mediated cAMP-PKA-CREB signaling pathway.	gabab	90-95	cAMP responsive element binding protein 1	Rattus norvegicus	116-120
31451579-7	2019	In a crossover pharmacological design with male and female adult participants, we found that drugs that affect the two dominant GABA receptor types in the brain - GABAA (clobazam) and GABAB (arbaclofen) - increase perceptual suppression during rivalry relative to a placebo.	gabab	184-189	GABA type A receptor-associated protein	Homo sapiens	128-141
31109961-12	2019	Using a mouse model of the human OPRM1 A118G single nucleotide polymorphism (SNP) (A112G in mice), we demonstrated that MOR and GABAB signaling coordinate in regulating mesolimbic dopamine neuronal firing via presynaptic regulation.	gabab	128-133	opioid receptor mu 1	Homo sapiens	33-38
31139935-8	2019	Additionally, temperature responses produced by GABAB agonist and antagonist are altered in a state of obesity and by administration of leptin.	gabab	48-53	leptin	Rattus norvegicus	136-142
30760775-12	2019	GABAA/B-receptor agonists attenuated ET-1-induced contraction in PAs and baclofen (GABAB-agonist) even in pulmonary veins (p < 0.001).	gabab	83-88	endothelin 1	Homo sapiens	37-41
30315127-3	2018	Regulator of G-protein signaling 7 (RGS7) has been shown to control GABAB effects, yet the specificity of its impacts on effector channels and underlying molecular mechanisms is poorly understood.	gabab	68-73	regulator of G protein signaling 7	Mus musculus	0-34
30315127-3	2018	Regulator of G-protein signaling 7 (RGS7) has been shown to control GABAB effects, yet the specificity of its impacts on effector channels and underlying molecular mechanisms is poorly understood.	gabab	68-73	regulator of G protein signaling 7	Mus musculus	36-40
29038006-7	2018	The results suggest that the microinjection of GABAA and GABAB agents into the CA1 region differently affects memory acquisition deficit induced by D-AP5.	gabab	57-62	carbonic anhydrase 1	Rattus norvegicus	79-82
30220332-13	2018	Responses of these GABAb sensitive neurons are also modulated by CGRP.	gabab	19-24	calcitonin related polypeptide alpha	Homo sapiens	65-69
29785777-5	2018	Moreover, several FXS phenotypes, including social behavior deficits, could be corrected in Fmr1 KO mice after acute treatment with GABAB agonists.	gabab	132-137	fragile X messenger ribonucleoprotein 1	Mus musculus	92-96
28844789-12	2017	Administration of a GABAB agonist remediated these electrophysiological alterations among male Pcdh10+/-mice.	gabab	20-25	protocadherin 10	Mus musculus	95-101
29131436-4	2017	Bath application of the non-specific GIRK channel blocker barium (200 mum) abolished outward currents evoked by GABAB receptors in CA1 pyramidal, but only partially blocked GABAB responses in layer 5 neurons.	gabab	112-117	carbonic anhydrase 1	Rattus norvegicus	131-134
29131436-6	2017	Tertiapin-Q partially blocked GABAB responses in CA1 pyramidal neurons, but was ineffective in blocking GABAB responses in neocortical layer 5 neurons.	gabab	30-35	carbonic anhydrase 1	Rattus norvegicus	49-52
29131436-7	2017	Consistent with the idea that GABAB receptors are coupled to two-pore domain potassium channels, the non-specific blockers quinidine and bupivacaine partially blocked GABAB responses in both layer 5 and CA1 neurons.	gabab	30-35	carbonic anhydrase 1	Rattus norvegicus	203-206
27876620-0	2017	The GABAB positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABAB receptors.	gabab	4-9	mitogen-activated protein kinase 3	Homo sapiens	71-77
28361168-10	2017	GABAB-mechanisms involved in GABA release play a likely important role in the leptin-mediated effects on NI neurons via functional leptin receptors.	gabab	0-5	leptin	Homo sapiens	78-84
28361168-10	2017	GABAB-mechanisms involved in GABA release play a likely important role in the leptin-mediated effects on NI neurons via functional leptin receptors.	gabab	0-5	leptin	Homo sapiens	131-137
27876620-1	2017	The present study shows that the GABAB positive allosteric modulators (PAMs) CGP7930 and GS39783 stimulate extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) signalling in cells that do not express functional GABAB receptors.	gabab	33-38	mitogen-activated protein kinase 3	Homo sapiens	163-169
27060477-0	2016	GABAB R/GSK-3beta/NF-kappaB signaling pathway regulates the proliferation of colorectal cancer cells.	gabab	0-5	glycogen synthase kinase 3 beta	Homo sapiens	8-17
27578262-10	2016	These findings indicate that SSD114, a molecule with a different chemical structure compared to known GABAB PAMs, is a novel GABAB PAM with potential usefulness in the GABAB-receptor research field.	gabab	125-130	peptidyl-glycine alpha-amidating monooxygenase	Cricetulus griseus	108-111
27426949-4	2016	Although considered exclusively inhibitory, here, GABAB mediates excitation by amplifying presynaptic Ca(2+) entry through Cav2.3 channels and potentiating co-release of glutamate, acetylcholine, and neurokinin B to excite interpeduncular neurons.	gabab	50-55	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	123-129
27462820-3	2016	We test the hypothesis that GIRK2 is necessary for the GABAB R agonist-induced infantile spasms phenotype in Ts.	gabab	55-60	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	28-33
27462820-4	2016	METHODS: We assessed the result of either genetic or pharmacological knockdown of the GIRK2 channel in Ts brain upon the GABAB R agonist-induced infantile spasms phenotype in the Ts mouse model of DS.	gabab	121-126	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	86-91
27462820-6	2016	RESULTS: The reduction of the copy number of Kcnj6 in Ts mice rescued the GABAB R agonist-induced infantile spasms phenotype.	gabab	74-79	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	45-50
27462820-7	2016	There was an increase in GABAB R-mediated GIRK2 currents in GIRK2-trisomic Ts mouse hippocampal neurons, which were normalized in the GIRK2-disomic Ts mice.	gabab	25-30	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	42-47
27462820-7	2016	There was an increase in GABAB R-mediated GIRK2 currents in GIRK2-trisomic Ts mouse hippocampal neurons, which were normalized in the GIRK2-disomic Ts mice.	gabab	25-30	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	60-65
27462820-8	2016	Similarly, pharmacological knockdown of the GIRK2 channel in Ts brain using the GIRK antagonist tertiapin-Q also rescued the GABAB R agonist-induced infantile spasms phenotype in Ts mutants.	gabab	125-130	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	44-49
27462820-9	2016	INTERPRETATION: The GABAB R-coupled GIRK2 channel is necessary for the GABAB R agonist-induced infantile spasms phenotype in the Ts mouse and may represent a novel therapeutic target for the treatment of infantile spasms in DS.	gabab	20-25	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	36-41
27060477-4	2016	Inhibition of GABAB R activated GSK-3beta by reducing the phosphorylation level of GSK-3beta.	gabab	14-19	glycogen synthase kinase 3 beta	Homo sapiens	83-92
27060477-8	2016	Overall, activation of GABAB R leaded to inhibition of GSK-3beta activation to repress the NF-kappaB function during colorectal cancer cell proliferation.	gabab	23-28	glycogen synthase kinase 3 beta	Homo sapiens	55-64
27060477-9	2016	This study revealed critical function of GABAB R/GSK-3beta/NF-kappaB signaling pathway on regulating proliferation of colorectal cancer cell, which might provide a potential therapeutic target for clinical colorectal cancer treatment.	gabab	41-46	glycogen synthase kinase 3 beta	Homo sapiens	49-58
27060477-4	2016	Inhibition of GABAB R activated GSK-3beta by reducing the phosphorylation level of GSK-3beta.	gabab	14-19	glycogen synthase kinase 3 beta	Homo sapiens	32-41
26499511-5	2016	Expression analysis revealed that while GABAB or extra-synaptic GABAA receptor prevalence is preserved in the MeCP2-deficient cortex, the expression of GAT-1 is significantly reduced from wild-type levels.	gabab	40-45	methyl CpG binding protein 2	Mus musculus	110-115
26780954-10	2016	The results of the present study demonstrated that ON markedly protected the brain against transient cerebral ischemic injury, and this effect was possibly mediated by the activation of the GABAB/cAMP/PKA/CREB signal transduction pathway.	gabab	190-195	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	201-204
26780954-10	2016	The results of the present study demonstrated that ON markedly protected the brain against transient cerebral ischemic injury, and this effect was possibly mediated by the activation of the GABAB/cAMP/PKA/CREB signal transduction pathway.	gabab	190-195	cAMP responsive element binding protein 1	Rattus norvegicus	205-209
25288769-7	2014	Stress resilience in GABAB(1b)(-/-) mice is coupled with increased proliferation and survival of newly born cells in the adult ventral hippocampus and increased stress-induced c-Fos activation in the hippocampus following early-life stress.	gabab	21-26	FBJ osteosarcoma oncogene	Mus musculus	176-181
26808347-0	2016	Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice.	gabab	10-15	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	69-83
26808347-5	2016	Accordingly, FsE triggers GABAB1 and GIRK2 internalization, leading to rapid and persistent weakening of GABAB-activated GIRK-mediated (GABAB-GIRK) currents.	gabab	105-110	gamma-aminobutyric acid (GABA) B receptor, 1	Mus musculus	26-32
26808347-5	2016	Accordingly, FsE triggers GABAB1 and GIRK2 internalization, leading to rapid and persistent weakening of GABAB-activated GIRK-mediated (GABAB-GIRK) currents.	gabab	105-110	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	37-42
26335644-3	2015	The absence of presynaptic GABAB response potentiates evoked GABA release from MSN efferents to the SNr and drives motor sensitization.	gabab	27-32	moesin	Mus musculus	79-82
25728691-6	2015	Optogenetic suppression of Sst neuron firing was sufficient to enhance EPSP amplitude and reduce failure rates, effects that were fully reversible and occluded by GABAb antagonists.	gabab	163-168	somatostatin	Homo sapiens	27-30
26033241-6	2016	PRAF2 concentration, relative to that of GB1 and GB2, tightly controls cell-surface receptor density and controls GABAB function in neurons.	gabab	114-119	PRA1 domain family member 2	Homo sapiens	0-5
26033241-8	2016	These data reveal an unanticipated major impact of specific ER gatekeepers on GPCR function and identify PRAF2 as a new molecular target with therapeutic potential for psychiatric and neurological diseases involving GABAB function.	gabab	216-221	PRA1 domain family 2	Mus musculus	105-110
26282581-13	2015	Indeed, the differences in inhibitory synaptic transmission between Fmr1 KO and wild-type (WT) mice were eliminated by a GABAB R antagonist.	gabab	121-126	fragile X messenger ribonucleoprotein 1	Mus musculus	68-72
26282581-16	2015	Our results suggest that the inhibitory synapse dysfunction in the cortico-hippocampal pathway of Fmr1 KO mice causes hyperexcitability and feed-forward circuit defects, which are mediated in part by a presynaptic GABAB R-dependent reduction in GABA release.	gabab	214-219	fragile X messenger ribonucleoprotein 1	Mus musculus	98-102
26180119-6	2015	Interestingly, the effects of neurotensin were not specific to D2R signaling as neurotensin also inhibited GABAB inhibitory postsynaptic currents in VTA dopamine neurons.	gabab	107-112	neurotensin	Mus musculus	30-41
26180119-6	2015	Interestingly, the effects of neurotensin were not specific to D2R signaling as neurotensin also inhibited GABAB inhibitory postsynaptic currents in VTA dopamine neurons.	gabab	107-112	neurotensin	Mus musculus	80-91
25679765-4	2015	We find that the endogenous GABAB agonist, GABA, is released from nociceptive nerve terminals, suggesting an autocrine feedback mechanism limiting TRPV1 sensitization.	gabab	28-33	transient receptor potential cation channel subfamily V member 1	Homo sapiens	147-152
25679765-5	2015	The effect of GABAB on TRPV1 is independent of canonical G protein signaling and rather relies on close juxtaposition of the GABAB1 receptor subunit and TRPV1.	gabab	14-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-28
25679765-5	2015	The effect of GABAB on TRPV1 is independent of canonical G protein signaling and rather relies on close juxtaposition of the GABAB1 receptor subunit and TRPV1.	gabab	14-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-158
24953818-6	2014	Inhibition of nAChR-evoked [(3)H]-GABA release by (R)-baclofen was time sensitive and the effect was lost after prolonged exposure to the GABAB agonist.	gabab	138-143	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	14-19
25242222-6	2014	GINIP null mice show impaired responsiveness to GABAB, but not to delta or mu opioid receptor agonist-mediated analgesia specifically in the spared nerve injury (SNI) model.	gabab	48-53	PHD finger protein 24	Mus musculus	0-5
25088910-2	2014	We previously reported partial overlap in the c-Fos expression patterns produced by GHB and the GABAB agonist, baclofen in rats.	gabab	96-101	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
23820624-3	2013	However, it is unknown whether E2 and STX can modulate GABAB signaling in neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons.	gabab	55-60	neuropeptide Y	Mus musculus	74-88
24796812-3	2014	We report here that the GABAB agonist baclofen reversibly suppresses SPW-R activity in rat hippocampal slices, presumably affecting the strength of neuronal coupling in the associative network of area CA3.	gabab	24-29	carbonic anhydrase 3	Rattus norvegicus	201-204
24836506-6	2014	Accordingly, genetic ablation of KCTD12 specifically alters GABAB responses in the brain.	gabab	60-65	potassium channel tetramerization domain containing 12	Homo sapiens	33-39
24424047-10	2014	These findings suggest that GABAB signaling may normally directly or indirectly inhibit Kiss1 expression, particularly in the BNST and MeA, and highlight the importance of studying kisspeptin populations outside the hypothalamus.	gabab	28-33	KiSS-1 metastasis-suppressor	Mus musculus	88-93
24550776-9	2014	We propose that the CaMKII holo-enzyme may be selectively activated by various GABAB-mediated pathways and that the presence of the betaCaMKII isoform determines their impact on inhibitory plasticity.	gabab	79-84	calcium/calmodulin-dependent protein kinase II alpha	Mus musculus	20-26
24275468-0	2014	Corticotropin-releasing factor-like peptide modifies the AMPA-, NMDA-dependent and GABAB-ergic properties of synaptic transmissions in vitro.	gabab	83-88	corticotropin releasing hormone	Rattus norvegicus	0-30
23804514-5	2013	Using electrophysiological experiments, we found that GABAB -Girk current deactivation kinetics was markedly faster in cells coexpressing Rgs7/Gbeta5.	gabab	54-59	regulator of G protein signaling 7	Homo sapiens	138-142
23804514-5	2013	Using electrophysiological experiments, we found that GABAB -Girk current deactivation kinetics was markedly faster in cells coexpressing Rgs7/Gbeta5.	gabab	54-59	G protein subunit beta 5	Homo sapiens	143-149
24793831-8	2014	1-Hz rTMS appears to increase the amount of inhibition following a TMS pulse, as demonstrated by the higher N100 and P60, which are thought to originate from GABAb-mediated inhibitory post-synaptic potentials.	gabab	158-163	PYD and CARD domain containing	Homo sapiens	6-9
24793831-8	2014	1-Hz rTMS appears to increase the amount of inhibition following a TMS pulse, as demonstrated by the higher N100 and P60, which are thought to originate from GABAb-mediated inhibitory post-synaptic potentials.	gabab	158-163	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	117-120
24734514-4	2014	GABAB, and 5-HT2A signalling directly influenced the cyclic AMP response element binding protein (CREB) expression, neuronal survival and ROS mediated cell damage which was confirmed from the gene expression of NF-kappaB, TNF-alpha, Akt-1 and SOD.	gabab	0-5	cAMP responsive element binding protein 1	Rattus norvegicus	53-96
24734514-4	2014	GABAB, and 5-HT2A signalling directly influenced the cyclic AMP response element binding protein (CREB) expression, neuronal survival and ROS mediated cell damage which was confirmed from the gene expression of NF-kappaB, TNF-alpha, Akt-1 and SOD.	gabab	0-5	cAMP responsive element binding protein 1	Rattus norvegicus	98-102
24734514-4	2014	GABAB, and 5-HT2A signalling directly influenced the cyclic AMP response element binding protein (CREB) expression, neuronal survival and ROS mediated cell damage which was confirmed from the gene expression of NF-kappaB, TNF-alpha, Akt-1 and SOD.	gabab	0-5	tumor necrosis factor	Rattus norvegicus	222-231
24734514-4	2014	GABAB, and 5-HT2A signalling directly influenced the cyclic AMP response element binding protein (CREB) expression, neuronal survival and ROS mediated cell damage which was confirmed from the gene expression of NF-kappaB, TNF-alpha, Akt-1 and SOD.	gabab	0-5	AKT serine/threonine kinase 1	Rattus norvegicus	233-246
24173622-6	2014	Post hoc analyses of studies involving the selective mGluR5 antagonist mavoglurant and the GABAB agonist arbaclofen have uncovered significant therapeutic responses following patient stratification according to FMR1 promoter methylation patterns or baseline severity of social withdrawal, respectively.	gabab	91-96	fragile X messenger ribonucleoprotein 1	Homo sapiens	211-215
23820624-3	2013	However, it is unknown whether E2 and STX can modulate GABAB signaling in neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons.	gabab	55-60	neuropeptide Y	Mus musculus	90-93
23820624-3	2013	However, it is unknown whether E2 and STX can modulate GABAB signaling in neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons.	gabab	55-60	agouti related neuropeptide	Mus musculus	119-123
23820624-4	2013	We used single-cell RT-PCR and whole cell patch clamping with selective pharmacological reagents to show that NPY/AgRP cells of mice express the GABAB-R1 and -R2 receptors and are hyperpolarized by the GABAB agonist baclofen in an E2-dependent manner.	gabab	145-150	neuropeptide Y	Mus musculus	110-113
23820624-4	2013	We used single-cell RT-PCR and whole cell patch clamping with selective pharmacological reagents to show that NPY/AgRP cells of mice express the GABAB-R1 and -R2 receptors and are hyperpolarized by the GABAB agonist baclofen in an E2-dependent manner.	gabab	145-150	agouti related neuropeptide	Mus musculus	114-118
23820624-8	2013	In gonadectomized mice of both sexes, E2 enhanced or attenuated the GABAB response in different NPY/AgRP cells.	gabab	68-73	neuropeptide Y	Mus musculus	96-99
23820624-8	2013	In gonadectomized mice of both sexes, E2 enhanced or attenuated the GABAB response in different NPY/AgRP cells.	gabab	68-73	agouti related neuropeptide	Mus musculus	100-104
23820624-9	2013	Coperfusing wortmannin with E2 or simply applying STX always enhanced the GABAB response.	gabab	74-79	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Mus musculus	50-53
23592240-7	2013	KCTD12 may suppress the proliferation of gastrointestinal cells through interference with GABAb signaling.	gabab	90-95	potassium channel tetramerization domain containing 12	Homo sapiens	0-6
23843532-4	2013	First, both GABAB antagonists and agonists block CXCL12-elicited chemotaxis in human breast cancer cells.	gabab	12-17	C-X-C motif chemokine ligand 12	Homo sapiens	49-55
23843532-5	2013	Second, a GABAB antagonist blocks the potentiation by CXCL12 of high-threshold Ca(2+) channels in rat neurons.	gabab	10-15	C-X-C motif chemokine ligand 12	Rattus norvegicus	54-60
23843532-6	2013	Third, electrophysiology in Xenopus oocytes and human embryonic kidney cell line 293 cells in which we coexpressed rat CXCR4 and the G-protein inward rectifier K(+) (GIRK) channel showed that GABAB antagonist and agonist modified CXCL12-evoked activation of GIRK channels.	gabab	192-197	C-X-C motif chemokine receptor 4	Rattus norvegicus	119-124
23843532-6	2013	Third, electrophysiology in Xenopus oocytes and human embryonic kidney cell line 293 cells in which we coexpressed rat CXCR4 and the G-protein inward rectifier K(+) (GIRK) channel showed that GABAB antagonist and agonist modified CXCL12-evoked activation of GIRK channels.	gabab	192-197	C-X-C motif chemokine ligand 12	Rattus norvegicus	230-236
23843532-7	2013	To investigate whether GABAB ligands bind to CXCR4, we expressed this receptor in heterologous systems lacking GABAB receptors and performed competition binding experiments.	gabab	23-28	C-X-C motif chemokine receptor 4	Homo sapiens	45-50
23843532-9	2013	Finally, using backscattering interferometry and lipoparticles containing only the CXCR4 receptor, we quantified the binding affinity for the GABAB ligands, confirming a direct interaction with the CXCR4 receptor.	gabab	142-147	C-X-C motif chemokine receptor 4	Homo sapiens	83-88
23843532-9	2013	Finally, using backscattering interferometry and lipoparticles containing only the CXCR4 receptor, we quantified the binding affinity for the GABAB ligands, confirming a direct interaction with the CXCR4 receptor.	gabab	142-147	C-X-C motif chemokine receptor 4	Homo sapiens	198-203
23303922-0	2013	NMDA and GABAB (KIR) conductances: the "perfect couple" for bistability.	gabab	9-14	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	16-19
21930121-0	2011	Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression.	gabab	11-16	brain-derived neurotrophic factor	Rattus norvegicus	81-85
24312860-11	2013	The ghrelin antiepileptic effect was completely antagonized by GABAB blockade.	gabab	63-68	ghrelin and obestatin prepropeptide	Rattus norvegicus	4-11
22806213-0	2012	GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.	gabab	0-5	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	127-132
22253714-6	2012	Principal FDR-corrected findings were that GABBR1 was down-regulated in alcoholics, cocaine addicts and P rats with congruent findings in NSF, implicated in GABAB signaling efficacy, potentially resulting in increased synaptic GABA.	gabab	157-162	gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus	43-49
22253714-6	2012	Principal FDR-corrected findings were that GABBR1 was down-regulated in alcoholics, cocaine addicts and P rats with congruent findings in NSF, implicated in GABAB signaling efficacy, potentially resulting in increased synaptic GABA.	gabab	157-162	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	138-141
17959251-4	2008	GPCR that can produce analgesia upon activation include opioid, cannabinoid, alpha2-adrenergic, muscarinic acetylcholine, gamma-aminobutyric acidB (GABAB), groups II and III metabotropic glutamate, and somatostatin receptors.	gabab	148-153	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	0-4
21502286-8	2011	N/OFQ activated a postsynaptic, G-protein coupled, inwardly rectifying potassium (GIRK) current that was sensitive to G-protein inactivation, blocked by the GIRK blocker SCH23390, and occluded by the GABAB agonist and potent GIRK activator, baclofen.	gabab	200-205	prepronociceptin	Homo sapiens	0-5
16177033-6	2005	The GABAB agonist baclofen significantly inhibited NPY expression stimulated by DEX, and the inhibitory action of insulin was completely abolished in the presence of either the GABAA antagonist bicuculline or the GABAB antagonist CGP35348 (p-3-aminopropyl-p-diethoxymethyl phosphoric acid).	gabab	4-9	neuropeptide Y	Rattus norvegicus	51-54
17093127-0	2007	Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.	gabab	59-64	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	0-6
15706241-1	2005	Metabotropic GABAB receptors predominantly function as heterodimers of GABAB(1) and GABAB(2) subunits, but GABAB(1) can also form functional receptors in the absence of GABAB(2).	gabab	13-18	gamma-aminobutyric acid (GABA) B receptor, 1	Mus musculus	71-79
15240800-6	2004	However, GABAB(1) exhibits a broader cellular expression pattern than GABAB(2), suggesting that GABAB(1) could be functional in the absence of GABAB(2).	gabab	9-14	gamma-aminobutyric acid (GABA) B receptor, 1	Mus musculus	96-104
15163674-0	2004	Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1: a brake on the NMDA response.	gabab	23-28	carbonic anhydrase 1	Homo sapiens	80-83
15605123-7	2004	3-APA is a potent GABAB agonist that does not penetrate the blood brain barrier.	gabab	18-23	glutamyl aminopeptidase	Rattus norvegicus	2-5
15324863-4	2004	Future studies aiming to elucidate the pathophysiology of IGEs may benefit from the use of subtype-specific opioid ligands, available now, and GABAB ligands, if and when they become available.	gabab	143-148	IGES	Homo sapiens	58-62
15240800-6	2004	However, GABAB(1) exhibits a broader cellular expression pattern than GABAB(2), suggesting that GABAB(1) could be functional in the absence of GABAB(2).	gabab	70-75	gamma-aminobutyric acid (GABA) B receptor, 1	Mus musculus	96-104
15240800-12	2004	Our data suggest that association of GABAB(2) with GABAB(1) is essential for receptor localization in distal processes but is not absolutely necessary for signaling.	gabab	37-42	gamma-aminobutyric acid (GABA) B receptor, 1	Mus musculus	51-59
12970075-26	2003	In addition, GABAB(1)-/- mice are hypersensitive to GABAA receptor stimulation, indicating that GABAB tone normally balances GABAA-mediated effects.	gabab	13-18	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	52-57
12970075-26	2003	In addition, GABAB(1)-/- mice are hypersensitive to GABAA receptor stimulation, indicating that GABAB tone normally balances GABAA-mediated effects.	gabab	13-18	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	125-130
11704764-4	2001	Low-concentration baclofen, a GABAB agonist, augmented mGluR1-mediated excitatory synaptic current produced by stimulating PFs.	gabab	30-35	glutamate metabotropic receptor 1	Homo sapiens	55-61
12713642-0	2003	Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, mu-opioid and NK-1 receptors.	gabab	72-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-20
12888542-5	2003	Furthermore, TA-CA1 LTP is insensitive to the blockade of fast inhibitory transmission (GABAA-mediated) and, interestingly, is dependent on GABAB-dependent slow inhibitory transmission.	gabab	140-145	carbonic anhydrase 1	Rattus norvegicus	16-19
10373443-1	1999	The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that displays 19-25% sequence identity to the gamma-aminobutyric acid type B (GABAB) and metabotropic glutamate (mGlu) receptors.	gabab	145-150	calcium sensing receptor	Homo sapiens	4-28
10373443-1	1999	The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that displays 19-25% sequence identity to the gamma-aminobutyric acid type B (GABAB) and metabotropic glutamate (mGlu) receptors.	gabab	145-150	calcium sensing receptor	Homo sapiens	30-33
9658051-1	1998	Intracellular recordings were obtained from pyramidal cells to examine gamma-aminobutyric acid-B (GABAB)-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices.	gabab	98-103	carbonic anhydrase 1	Rattus norvegicus	141-144
10064833-0	1999	Neuropeptide Y blocks GABAB-induced phase-shifts of the suprachiasmatic circadian clock in vitro.	gabab	22-27	neuropeptide Y	Homo sapiens	0-14
10218776-11	1999	This plasticity involves an interaction between a Ca2(+)-mediated postsynaptic depression and an N-methyl-D-aspartate-mediated potentiation of GABAA and GABAB inhibition, and these processes are differentially sensitive to tetanization parameters.	gabab	153-158	carbonic anhydrase 2	Rattus norvegicus	50-53
9468094-5	1998	The gastrin and somatostatin responses to 10(-4) M GABA were completely inhibited by the GABA(A) antagonist bicuculline (10(-5) M) and the cholinergic blocker atropine(l0(-7) M), whereas the GABAB antagonist CGP 35348 (5 x 10(-5) M) was ineffective.	gabab	191-196	gastrin	Rattus norvegicus	4-11
9689466-6	1998	This modulation of bioelectric activity was unlikely due to alterations of the postsynaptic GABA-system as hyperpolarizing GABAA- and GABAB-responses of CA3-neurons were hardly affected.	gabab	134-139	carbonic anhydrase 3	Homo sapiens	153-156
9468094-5	1998	The gastrin and somatostatin responses to 10(-4) M GABA were completely inhibited by the GABA(A) antagonist bicuculline (10(-5) M) and the cholinergic blocker atropine(l0(-7) M), whereas the GABAB antagonist CGP 35348 (5 x 10(-5) M) was ineffective.	gabab	191-196	somatostatin	Rattus norvegicus	16-28
9192693-4	1997	Typical GIRK currents could be activated by endogenous GABAB, serotonin 5-HT1A, and adenosine A1 receptors in neurons coinfected with GIRK1+2 or GIRK1+4.	gabab	55-60	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	134-141
9364072-0	1997	Partial hippocampal kindling decreases efficacy of presynaptic GABAB autoreceptors in CA1.	gabab	63-68	carbonic anhydrase 1	Rattus norvegicus	86-89
9192693-4	1997	Typical GIRK currents could be activated by endogenous GABAB, serotonin 5-HT1A, and adenosine A1 receptors in neurons coinfected with GIRK1+2 or GIRK1+4.	gabab	55-60	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	134-139
8797018-6	1996	Another muscarinic response thought to be mediated by PKC-inhibition of GABAB-mediated hyperpolarization-was reduced by extracellular H7 treatment, suggesting that the coupling between mAChRs and protein kinase activity was maintained in whole-cell recordings.	gabab	72-77	protein kinase C, gamma	Rattus norvegicus	54-57
9250387-2	1997	Electrical stimulation of inhibitory cells or fibres in the CA1 subfield of the hippocampus yields a biphasic inhibitory postsynaptic potential (IPSP) in pyramidal cells, consisting of an early GABAA- and a late GABAB-mediated component.	gabab	212-217	carbonic anhydrase 1	Homo sapiens	60-63
9152382-4	1997	In particular, the inhibition of GHB dehydrogenase by valproate or ethosuximide and the blockade of GABA-T by aminooxyacetic acid induce the disappearance of the GABA-like effect of GHB at GABAB, but also at GABAA, receptors.	gabab	189-194	4-aminobutyrate aminotransferase	Rattus norvegicus	100-106
9203224-0	1997	Growth hormone response to the GABAB agonist baclofen in major depressive disorder.	gabab	31-36	growth hormone 1	Homo sapiens	0-14
9159640-6	1997	GIRKs, as heteromultimers, compose the G protein-gated Kir (KG) channels, which are regulated by a variety of Gi/Go-coupled inhibitory neurotransmitter receptors such as m2-mus-carinic, serotonergic (5HT1A), GABAB, somatostatin and opioid (mu, delta, kappa) receptors.	gabab	208-213	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog	Xenopus laevis	200-205
9059206-12	1997	The results demonstrate that sevoflurane at clinical concentrations activated both GABAA- and GABAB-mediated inhibitions in area CA1 of the hippocampus, and that sevoflurane and GABA agonists (muscimol and baclofen) acted on different domains on the GABAA and GABAB receptors, respectively.	gabab	94-99	carbonic anhydrase 1	Rattus norvegicus	129-132
7623286-7	1995	However, recording intracellularly from CA1 cells, stimulation of the perforant path produced prominent fast GABAA and slow GABAB IPSPs often preceded by small EPSPs.	gabab	124-129	carbonic anhydrase 1	Rattus norvegicus	40-43
7472361-0	1995	Decreased monosynaptic GABAB-mediated inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells in the aged rat: pharmacological characterization and possible mechanisms.	gabab	23-28	carbonic anhydrase 1	Rattus norvegicus	88-91
7589200-4	1995	Stimulation of the stratum radiatum induced in CA1 pyramidal cells an early excitatory postsynaptic potential (EPSP) followed by a fast GABAA and a slow GABAB-mediated inhibitory postsynaptic potentials (IPSPs).	gabab	153-158	carbonic anhydrase 1	Rattus norvegicus	47-50
8385620-13	1993	In anaesthetised rats the effects of the three new GABAB antagonists and of CGP 35348 were investigated on the paired-pulse inhibition of the population spikes evoked in the CA1 area of the hippocampus.	gabab	51-56	carbonic anhydrase 1	Rattus norvegicus	174-177
7714569-0	1995	Postnatal development of pre- and postsynaptic GABAB-mediated inhibitions in the CA3 hippocampal region of the rat.	gabab	47-52	carbonic anhydrase 3	Rattus norvegicus	81-84
7714569-2	1995	Intracellular recordings were made from adult and neonatal rat hippocampal slices to study the postnatal development of GABAB-mediated inhibition in CA3 pyramidal neurons.	gabab	120-125	carbonic anhydrase 3	Rattus norvegicus	149-152
7714569-18	1995	We conclude that postsynaptic GABAB-mediated inhibition is absent or minimal during the first postnatal days in the CA3 region.	gabab	30-35	carbonic anhydrase 3	Rattus norvegicus	116-119
7897499-2	1994	Monosynaptic gamma-aminobutyric acid-A (GABAA)-mediated inhibitory postsynaptic currents (IPSCs) were evoked in CA1 pyramidal neurons in the hippocampal slice preparation by direct stimulation of the interneurons in the presence of glutamatergic blockers and intracellular QX-314 to block GABAB-mediated postsynaptic inhibition.	gabab	289-294	carbonic anhydrase 1	Rattus norvegicus	112-115
7965762-4	1994	Administration of the GABAB agonist baclofen, but not the GABAA agonist isoguvacine, produced dose- and time-related decreases in intermediate lobe DOPAC concentrations and corresponding increases in plasma alpha MSH concentrations.	gabab	22-27	proopiomelanocortin	Homo sapiens	207-216
7834368-2	1994	We showed in a previous study that the GABAB-mediated slow inhibitory postsynaptic potential (IPSP) induced in CA1 pyramidal neurons by electrical stimulation of stratum radiatum, is depressed in the hippocampus of the aged rat.	gabab	39-44	carbonic anhydrase 1	Rattus norvegicus	111-114
8388308-7	1993	The increased number of GABAB binding sites was selective, because binding to NMDA sites ([3H]glutamate binding) and to GABAA sites ([3H]muscimol binding) was not significantly different in the two strains.	gabab	24-29	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	120-125
7884464-0	1994	GABAB and adenosine receptors mediate enhancement of the K+ current, IAHP, by reducing adenylyl cyclase activity in rat CA3 hippocampal neurons.	gabab	0-5	carbonic anhydrase 3	Rattus norvegicus	120-123
1481137-10	1992	Therefore, 5-HT may reduce GABAB IPSPs in CA3 pyramidal cells 1) by a postsynaptic action on pyramidal cells and 2) by a selective presynaptic action on GABAergic interneurons mediating the GABAB IPSP.	gabab	27-32	carbonic anhydrase 3	Rattus norvegicus	42-45
1481137-0	1992	Reduction of GABAB inhibitory postsynaptic potentials by serotonin via pre- and postsynaptic mechanisms in CA3 pyramidal cells of rat hippocampus in vitro.	gabab	13-18	carbonic anhydrase 3	Rattus norvegicus	107-110
1353275-10	1992	The discrepancy in the pharmacological profile of the GABAB glut-IPSPs and of the GABAB late IPSPs may suggest the presence of two GABAB mechanisms in CA1 pyramidal cells.	gabab	82-87	carbonic anhydrase 1	Homo sapiens	151-154
1353275-10	1992	The discrepancy in the pharmacological profile of the GABAB glut-IPSPs and of the GABAB late IPSPs may suggest the presence of two GABAB mechanisms in CA1 pyramidal cells.	gabab	82-87	carbonic anhydrase 1	Homo sapiens	151-154
1578282-7	1992	We conclude that 5-HT activates presynaptic 5-HT1B receptors that inhibit the release of GABA onto GABAB but not GABAA receptors.	gabab	99-104	5-hydroxytryptamine receptor 1B	Rattus norvegicus	44-50
1868822-6	1991	The action of GPT in our model also resembled that of the GABAB agonist baclofen in its facilitation of reticular and segmental inhibitory mechanisms and its depression of segmental excitatory mechanisms, but differed in its effect on excitatory mechanisms descending from the reticular formation.	gabab	58-63	glutamic--pyruvic transaminase	Homo sapiens	14-17
1941636-8	1991	Pretreatment in the A10 region with the GABAB agonist baclofen, blocked cocaine-stimulated motor activity in control animals, but not in PTX-pretreated animals, indicating that the PTX treatment had uncoupled the GABAB receptor.	gabab	40-45	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	20-23
1941636-10	1991	We hypothesize that the sensitized responses to cocaine, amphetamine and stress produced by PTX results from a decrease in dopamine D2 and GABAB-mediated inhibitory control of A10 dopamine neurons.	gabab	139-144	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	176-179
1760748-7	1991	These results suggest that GABAB-mediated responses in CA1 hippocampal pyramidal neurons are relatively resistant to the acute effects of ethanol, but that continuous exposure to ethanol sufficient to induce physical dependence may evoke an adaptive reduction in some GABAB receptor mediated responses.	gabab	27-32	carbonic anhydrase 1	Rattus norvegicus	55-58
2169426-15	1990	In conclusion, the pharmacological features of muscimol I type GABA receptors are partly comparable to those of mammalian GABAA receptors, except for the influences of bicuculline and diazepam: the features of the baclofen type GABA receptor, which did not occur with muscimol I type receptors in the same neurone, were similar to those of GABAB.	gabab	340-345	GABA type A receptor-associated protein	Homo sapiens	63-76
1850318-2	1991	The GABAB agonist, baclofen, increased population spike (PS) amplitudes in the dentate evoked by perforant path stimulation but decreased PS amplitudes in CA1 evoked by Schaffer collateral stimulation, whereas the GABAA antagonist, bicuculline, increased PS amplitudes in both regions.	gabab	4-9	carbonic anhydrase 1	Rattus norvegicus	155-158
1850318-6	1991	The GABAB antagonist, phaclofen, selectively reversed the effects of baclofen on PP inhibition in both the dentate and CA1.	gabab	4-9	carbonic anhydrase 1	Rattus norvegicus	119-122
2174069-3	1990	In the present study, the sensitivity of GABAB binding sites was assessed in nine healthy men and 10 depressed patients via the plasma growth hormone (GH) response to acute baclofen administration (20 mg p.o.).	gabab	41-46	growth hormone 1	Homo sapiens	135-149
2174069-3	1990	In the present study, the sensitivity of GABAB binding sites was assessed in nine healthy men and 10 depressed patients via the plasma growth hormone (GH) response to acute baclofen administration (20 mg p.o.).	gabab	41-46	growth hormone 1	Homo sapiens	151-153
34812900-4	2022	Recently, we demonstrated that COR659, a novel GABAB PAM, effectively reduced (i) alcohol drinking under the 2-bottle choice regimen, (ii) alcohol self-administration under both fixed and progressive ratio schedules of reinforcement, and (iii) cue-induced reinstatement of alcohol-seeking behavior in Sardinian alcohol-preferring (sP) rats.	gabab	47-52	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	53-56
2156219-0	1990	Block of GABAb-activated K+ conductance by kainate and quisqualate in rat CA3 hippocampal pyramidal neurones.	gabab	9-14	carbonic anhydrase 3	Rattus norvegicus	74-77
34599513-2	2022	Analgesic alpha-conotoxin Vc1.1 has been shown to activate GABAB R resulting in inhibition of Cav2.2 and Cav2.3 channels in mammalian primary afferent neurons.	gabab	59-64	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	94-100
34599513-2	2022	Analgesic alpha-conotoxin Vc1.1 has been shown to activate GABAB R resulting in inhibition of Cav2.2 and Cav2.3 channels in mammalian primary afferent neurons.	gabab	59-64	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	105-111