PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29172489-1	2018	Reaction of [Pd(IPr)2] (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) and O2 leads to the surprising discovery that at low temperature the initial reaction product is a highly labile peroxide complex cis-[Pd(IPr)2(eta2-O2)].	Inosine Pranobex	16-19	DNA polymerase iota	Homo sapiens	224-228
26011933-1	2015	Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity.	Inosine Pranobex	47-59	nitric oxide synthase 2	Homo sapiens	0-4
26538483-0	2016	Cp*Co(IPr): synthesis and reactivity of an unsaturated Co(i) complex.	Inosine Pranobex	5-10	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	55-60
27642212-9	2015	[Ni(PCPMe-iPr)(eta2-BH4)] (5) loses readily BH3 at elevated temperatures in the presence of NEt3 to form 6.	Inosine Pranobex	10-13	tetraspanin 2	Homo sapiens	92-96
25604107-1	2015	The cycloisomerization reaction of 1-(iodoethynyl)-2-(1-methoxyalkyl)arenes and related 2-alkyl-substituted derivatives gives the corresponding 3-iodo-1-substituted-1H-indene under the catalytic influence of IPrAuNTf2 [IPr=1,3-bis(2,6-diisopropyl)phenylimidazol-2-ylidene; NTf2=bis(trifluoromethanesulfonyl)imidate].	Inosine Pranobex	208-211	nuclear transport factor 2	Homo sapiens	213-217
21957729-0	2011	The effect of different doses of methisoprinol on the percentage of CD4+ and CD8+ T lymphocyte subpopulation and the antibody titers in pigeons immunised against PPMV-1.	Inosine Pranobex	33-46	CD8a molecule	Homo sapiens	77-80
22092141-6	2012	The same sequence of reactions starting from 14 and the 1-thiolate of Galp afforded the per-O,S-acetyl derivative of Galp-beta-S-(1 4)-3,4-dithio-alpha-D-Glcp-O-iPr (23), which was selectively S-deacetylated to give 25.	Inosine Pranobex	161-164	galanin like peptide	Homo sapiens	70-74
22092141-6	2012	The same sequence of reactions starting from 14 and the 1-thiolate of Galp afforded the per-O,S-acetyl derivative of Galp-beta-S-(1 4)-3,4-dithio-alpha-D-Glcp-O-iPr (23), which was selectively S-deacetylated to give 25.	Inosine Pranobex	161-164	galanin like peptide	Homo sapiens	117-121
21597617-3	2011	The formation equilibria of [(BL(iPr))Pd(H(2)O)(2)](2+), where BL(iPr) is 1,2-bis(1,3diisopropyl-4,5-dimethylimidazolin-2-imino)ethane, and [(TL(tBu))Pd(H(2)O)](2+) with some biologically relevant ligands (l-Met, 5"-GMP and l-His) were also studied.	Inosine Pranobex	33-36	5'-nucleotidase, cytosolic II	Homo sapiens	216-219
21823576-5	2011	Cleavage of the Roussin"s Red "ester" (mu-SPh)(2)[Fe(NO)(2)](2) with either NHC or imidazole results in the formation of (NHC-iPr)(PhS)Fe(NO)(2) (7) and (Imid-iPr)(PhS)Fe(NO)(2) (10) (Imid-iPr = 2-isopropylimidazole).	Inosine Pranobex	125-129	surfactant associated 3	Homo sapiens	42-45
21823576-5	2011	Cleavage of the Roussin"s Red "ester" (mu-SPh)(2)[Fe(NO)(2)](2) with either NHC or imidazole results in the formation of (NHC-iPr)(PhS)Fe(NO)(2) (7) and (Imid-iPr)(PhS)Fe(NO)(2) (10) (Imid-iPr = 2-isopropylimidazole).	Inosine Pranobex	126-129	surfactant associated 3	Homo sapiens	42-45
21957729-1	2011	As immunosuppression in pigeons is common and results in reduced post-vaccination immunity and lower health status of the birds, studies have been taken up aimed at evaluation of the effect of three doses of methisoprinol on the percentage of CD4+ and CD8+ T lymphocyte subpopulation in peripheral blood and in the spleen and the titre of anti-NDV antibodies in the serum of pigeons in four groups (A, B, C, D), with 20 birds each.	Inosine Pranobex	208-221	CD4 molecule	Homo sapiens	243-246
21957729-1	2011	As immunosuppression in pigeons is common and results in reduced post-vaccination immunity and lower health status of the birds, studies have been taken up aimed at evaluation of the effect of three doses of methisoprinol on the percentage of CD4+ and CD8+ T lymphocyte subpopulation in peripheral blood and in the spleen and the titre of anti-NDV antibodies in the serum of pigeons in four groups (A, B, C, D), with 20 birds each.	Inosine Pranobex	208-221	CD8a molecule	Homo sapiens	252-255
21957729-5	2011	The findings indicate that methisoprinol administered intramuscularly at 100 and 200 mg/kg of body weight for 3 successive days before vaccination against paramyxovirosis mainly stimulates the mechanisms of non-specific humoral and cellular immunity, which is indicated by a higher percentage of the subpopulation of CD4+ T lymphocytes in peripheral blood and in the spleen and a higher titre of anti-NDV antibodies.	Inosine Pranobex	27-40	CD4 molecule	Homo sapiens	317-320
7684118-6	1993	At the end of the trial, side effects and elevated serum alanine aminotransferase (ALT/GPT) levels occurred with higher frequency in Isoprinosine-treated patients.	Inosine Pranobex	133-145	glutamic--pyruvic transaminase	Homo sapiens	57-81
18278941-1	2008	Anti and syn conformers, due to restricted sp(2)-sp(2) bond rotation, were detected in hindered 1,8-diarylbiphenylenes, the aryl moieties being phenyl groups bearing 0micron-alkyl substituents such as Me, Et, i-Pr, and t-Bu.	Inosine Pranobex	209-213	synemin	Homo sapiens	9-12
8744687-2	1995	Interferon (IFN) induction in leukocytes of cows with fatty liver, elevated ketone bodies, free fatty acids, bilirubin concentration and high aspartate aminotransferase (AST) activity, revealed impaired IFN production which was not improved by using known immunomodulators such as isoprinosine, levamisole, TFX and lactoferrin.	Inosine Pranobex	281-293	interferon alpha-H	Bos taurus	0-10
8744687-2	1995	Interferon (IFN) induction in leukocytes of cows with fatty liver, elevated ketone bodies, free fatty acids, bilirubin concentration and high aspartate aminotransferase (AST) activity, revealed impaired IFN production which was not improved by using known immunomodulators such as isoprinosine, levamisole, TFX and lactoferrin.	Inosine Pranobex	281-293	interferon alpha-H	Bos taurus	12-15
9950305-6	1999	CONCLUSION: Attempts at immunomodulation using isoprinosine in the dose and for the duration used may increase the total numbers of both CD4 and CD8 T-lymphocytes but is ineffective in prevention of respiratory tract infections in childhood.	Inosine Pranobex	47-59	CD4 molecule	Homo sapiens	137-140
9950305-6	1999	CONCLUSION: Attempts at immunomodulation using isoprinosine in the dose and for the duration used may increase the total numbers of both CD4 and CD8 T-lymphocytes but is ineffective in prevention of respiratory tract infections in childhood.	Inosine Pranobex	47-59	CD8a molecule	Homo sapiens	145-148
7684118-6	1993	At the end of the trial, side effects and elevated serum alanine aminotransferase (ALT/GPT) levels occurred with higher frequency in Isoprinosine-treated patients.	Inosine Pranobex	133-145	glutamic--pyruvic transaminase	Homo sapiens	87-90
1718853-5	1991	There was a significant increase in the production of IFN-gamma but a decrease in the secretion of IL-3 and IL-4 by the spleen cells of isoprinosine-treated mice in response to concanavalin A with or without L. major infection compared to untreated controls.	Inosine Pranobex	136-148	interleukin 3	Mus musculus	99-103
1718853-5	1991	There was a significant increase in the production of IFN-gamma but a decrease in the secretion of IL-3 and IL-4 by the spleen cells of isoprinosine-treated mice in response to concanavalin A with or without L. major infection compared to untreated controls.	Inosine Pranobex	136-148	interleukin 4	Mus musculus	108-112
1722191-0	1991	Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro.	Inosine Pranobex	10-22	interleukin 2	Mus musculus	26-30
1722191-0	1991	Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro.	Inosine Pranobex	10-22	interleukin 4	Mus musculus	46-50
1722191-2	1991	Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro.	Inosine Pranobex	0-12	interleukin 2	Mus musculus	22-26
1722191-2	1991	Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro.	Inosine Pranobex	0-12	interleukin 2	Mus musculus	70-74
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	CD2 molecule	Homo sapiens	303-306
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	CD4 molecule	Homo sapiens	313-316
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	CD19 molecule	Homo sapiens	329-333
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	CD8a molecule	Homo sapiens	318-321
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	keratin 20	Homo sapiens	335-339
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	CD14 molecule	Homo sapiens	323-327
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	interleukin 2 receptor subunit alpha	Homo sapiens	341-345
2479277-4	1989	After isoprinosine administration to 7 patients for several days a significant increase in plasma IFN activity was observed and their PBMC responded to stimulation by producing IFN.	Inosine Pranobex	6-18	interferon alpha 1	Homo sapiens	98-101
1702899-4	1990	Isoprinosine significantly enhanced the lymphoproliferative response after stimulation with phytohaemagglutinin (PHA) and purified derivative of tuberculin (PPD), while isoprinosine had no effect on the following immune parameters: the expression of surface markers on blood mononuclear cells including CD2, CD3, CD4, CD8, CD14, CD19, CD20, CD25, leu-8, and HLA-DR.	Inosine Pranobex	0-12	selectin L	Homo sapiens	347-352
35549174-3	2022	This design strategy is demonstrated in the group of trinuclear Co(III) spin-crossover compounds ((CpCo(OP(OR)2)3)2Co)(SbCl6) where Cp = cyclopentadienyl and R = Me (1), Et (2), i-Pr (3), and t-Bu (4).	Inosine Pranobex	178-182	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	64-71
2479277-4	1989	After isoprinosine administration to 7 patients for several days a significant increase in plasma IFN activity was observed and their PBMC responded to stimulation by producing IFN.	Inosine Pranobex	6-18	interferon alpha 1	Homo sapiens	177-180
2479277-5	1989	The long-term effect of isoprinosine on the IFN response was evaluated in 3 patients who had been treated for 57-88 days.	Inosine Pranobex	24-36	interferon alpha 1	Homo sapiens	44-47
2479277-7	1989	However, discontinuation of isoprinosine for 10 days resulted in recurrence of the inactivation state of the IFN system.	Inosine Pranobex	28-40	interferon alpha 1	Homo sapiens	109-112
2469797-0	1988	Isoprinosine potentiation of human peripheral blood mononuclear cell response to mitogens: kinetics and effect on expression of the IL-2 receptor and the activity of interleukin 2.	Inosine Pranobex	0-12	interleukin 2 receptor subunit beta	Homo sapiens	132-145
2469797-0	1988	Isoprinosine potentiation of human peripheral blood mononuclear cell response to mitogens: kinetics and effect on expression of the IL-2 receptor and the activity of interleukin 2.	Inosine Pranobex	0-12	interleukin 2	Homo sapiens	166-179
2469797-4	1988	Increased interleukin-2 activity was detected in three out of nine supernatants from PHA activated mononuclear cells which were cultured in the presence of isoprinosine.	Inosine Pranobex	156-168	interleukin 2	Homo sapiens	10-23
2444374-6	1987	Isoprinosine induced an increase in both regulator Th (Leu3+ Leu8+) and inducer Th (Leu3+ Leu8+) subsets of helper T cells while potentiating the expression of Ia antigen on helper T cells and monocytes during mitogen-driven DNA synthesis.	Inosine Pranobex	0-12	selectin L	Homo sapiens	61-65
2458693-0	1988	Anti-p24 antibody reactivity in the acquired immunodeficiency syndrome (AIDS)-related complex treated with isoprinosine.	Inosine Pranobex	107-119	transmembrane p24 trafficking protein 2	Homo sapiens	5-8
2452254-5	1987	Patients receiving 3 g/day isoprinosine showed significant increase in NK cells, a major subset of which bears the Leu 7 surface antigen, and in NK cell function as early as at the termination of treatment.	Inosine Pranobex	27-39	beta-1,3-glucuronyltransferase 1	Homo sapiens	115-120
2444374-6	1987	Isoprinosine induced an increase in both regulator Th (Leu3+ Leu8+) and inducer Th (Leu3+ Leu8+) subsets of helper T cells while potentiating the expression of Ia antigen on helper T cells and monocytes during mitogen-driven DNA synthesis.	Inosine Pranobex	0-12	selectin L	Homo sapiens	90-94
2424829-0	1986	Effect of isoprinosine on sialylation of interleukin-2.	Inosine Pranobex	10-22	interleukin 2	Homo sapiens	41-54
2442109-6	1987	Isoprinosine and inosine and, more markedly, adenosine, augmented interleukin-2 activity in concanavalin A supernatants of spleen cells from the same animals.	Inosine Pranobex	0-12	interleukin 2	Mus musculus	66-79
2442634-0	1987	Isoprinosine enhances PHA responses and has potential effect on natural killer cell (NK) activity of uremic patients in vitro.	Inosine Pranobex	0-12	lamin B receptor	Homo sapiens	22-25
2442634-2	1987	PHA and PPD induced stimulations of DNA synthesis and interleukin-2 (Il-2) production and NK cell activity were measured from peripheral blood mononuclear cells cultured with and without isoprinosine.	Inosine Pranobex	187-199	lamin B receptor	Homo sapiens	0-3
2442634-3	1987	PHA responses were enhanced by isoprinosine (100 micrograms/ml) both in the patient group (p less than 0.001) and in the control group (p less than 0.05) but PPD responses in neither.	Inosine Pranobex	31-43	lamin B receptor	Homo sapiens	0-3
2424829-1	1986	The effects of Isoprinosine (ISO) on interleukin-2 (IL-2) production by human peripheral blood mononuclear cells (PBMC) were investigated.	Inosine Pranobex	29-32	interleukin 2	Homo sapiens	37-50
2427461-0	1986	Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS).	Inosine Pranobex	0-12	interleukin 1 alpha	Homo sapiens	24-37
2427461-1	1986	The in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study.	Inosine Pranobex	24-36	interleukin 1 alpha	Homo sapiens	64-68
2428762-0	1986	In vivo effect of isoprinosine on interleukin-2 production, lymphocyte mitogenesis and NK activity in normal and cyclophosphamide immunosuppressed mice.	Inosine Pranobex	18-30	interleukin 2	Mus musculus	34-47
2428762-6	1986	Administration of isoprinosine every day (50 mg/kg) augmented Con A induced mitogenesis, IL-2 production and NK activity in animals treated with cyclophosphamide, but not in normal mice.	Inosine Pranobex	18-30	interleukin 2	Mus musculus	89-93
2428762-8	1986	The effect of isoprinosine on immune responses may be mediated in part by changes in IL-2 activity.	Inosine Pranobex	14-26	interleukin 2	Mus musculus	85-89
2412742-0	1985	Ability of isoprinosine to restore interleukin-2 production and T cell proliferation in autoimmune mice.	Inosine Pranobex	11-23	interleukin 2	Mus musculus	35-48
2412742-4	1985	Injection of isoprinosine after antigen immunization restored both antigen presentation and IL-2 production.	Inosine Pranobex	13-25	interleukin 2	Mus musculus	92-96
32773358-10	2020	CONCLUSION: The KAP-IAD-Q demonstrated good psychometric properties and is effective in measuring levels of IAD-related KAP among nurses.	Inosine Pranobex	20-23	cyclin dependent kinase inhibitor 3	Homo sapiens	16-19
6207122-0	1984	Effect of isoprinosine on interleukin 1 and 2 production and on suppressor cell activity in pokeweed mitogen stimulated cultures of B and T cells.	Inosine Pranobex	10-22	interleukin 1 alpha	Homo sapiens	26-39
6207122-1	1984	Isoprinosine appeared to potentiate the production of interleukin 1 and interleukin 2 in cultures of lipopolysaccharide stimulated human monocytes and phytohemagglutinin stimulated cultures of blood mononuclear cells respectively at pharmacological drug levels.	Inosine Pranobex	0-12	interleukin 1 alpha	Homo sapiens	54-67
6207122-1	1984	Isoprinosine appeared to potentiate the production of interleukin 1 and interleukin 2 in cultures of lipopolysaccharide stimulated human monocytes and phytohemagglutinin stimulated cultures of blood mononuclear cells respectively at pharmacological drug levels.	Inosine Pranobex	0-12	interleukin 2	Homo sapiens	72-85
2581997-0	1985	Partial restoration of impaired interleukin-2 production and Tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro.	Inosine Pranobex	174-186	interleukin 2	Homo sapiens	32-45
2581997-0	1985	Partial restoration of impaired interleukin-2 production and Tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro.	Inosine Pranobex	174-186	interleukin 2 receptor subunit alpha	Homo sapiens	61-72
2581997-0	1985	Partial restoration of impaired interleukin-2 production and Tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro.	Inosine Pranobex	174-186	interleukin 2	Homo sapiens	83-96
2409037-6	1985	In the presence of ISO, ConA-induced lymphocyte proliferation, NK activity, neutrophil chemotaxis, and IL-2 production were restored to normal or near normal levels in 50 of the 55 (90.0%), 35 of the 41 (85.3%), 44 of the 52 (84.6%), and 25 of the 35 (71.4%) aging humans, respectively.	Inosine Pranobex	19-22	interleukin 2	Homo sapiens	103-107
6190598-8	1983	The mechanism responsible for these effects is not known but IL-2 production by patient lymphocytes in vitro which was low for both RA (P less than 0.01) and SLE (P less than 0.02) increased significantly (P less than 0.05) when SLE lymphocytes were cultured with IPS.	Inosine Pranobex	264-267	interleukin 2	Homo sapiens	61-65
16743050-1	1977	iPr(2)P-F (di-isopropyl phosphorofluoridate) administration to rats produces a liver-dependent specific elevation of plasma beta-glucuronidase activity.	Inosine Pranobex	0-3	glucuronidase, beta	Rattus norvegicus	124-142
32773358-10	2020	CONCLUSION: The KAP-IAD-Q demonstrated good psychometric properties and is effective in measuring levels of IAD-related KAP among nurses.	Inosine Pranobex	20-23	cyclin dependent kinase inhibitor 3	Homo sapiens	120-123
31434164-0	2020	Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression.	Inosine Pranobex	0-16	killer cell lectin like receptor K1	Homo sapiens	90-95